UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON D.C., 20460 

OFFICE OF 

CHEMICAL SAFETY AND 

POLLUTION PREVENTION 

DP Barcodes: D411540, 414403, 416312 

PC Code: 000325 

Date: November 25, 2013 

MEMORANDUM 

SUBJECT: 

FROM: 

REVIEWED: 

BY: 

THROUGH: 

TO: 

Drinking Water Assessment for the Proposed Uses ofMetrafenone [(3-bromo-6-

methyoxy-2-methylphenyl) (2,3,4-trimethoxy-6-methylphenyl) methanone] on P0me 

Fruits, Fruiting Vegetables, Peach Subgroup 12-12B, Apricot, Cherry Subgroup 12-12A, 

Cucurbit Vegetables (Group 9), and Fruit, Small, Vine Climbing (except Fuzzy 

Kiwifruit) Subgroup 13-07F 

James A. Hetrick, Ph.D, Senior Scienti0.du! U ~u{ Environmental Risk Branch III 

Environmental Fate and Effects Division (7507P) _c> ~ 

Rosanna Louie-Juzwiak, RAPL {}lu- <::f--

Rochelle Bohaty, Ph.D., Chemis~ 1\ , • ::::::s:::i'C~ 

Environmental Risk Branch III ~ ~\ ""t\ 

Environmental Fate and Effects Division (7507P) 

nl25}wr~ 

\\\Q;"~\~\:, 

DanaSpatz,BranchChief ~ ~ l\)"l-~]~13 Environmental Risk Branch III~'~ Environmental Fate and Effects Division (7507P) 

Christina Swartz, Branch Chief 

Registration Action Branch 2 

Health Effects Division (7509P) 

Barbara Madden, Team Leader 

Risk Integration Minor Use and Emergency Response Branch 

Registration Division (7505P) 

Tony Kish, Product Manager 22 

Rosemary Keams, Reviewer · 

Cynthia Giles-Parker, Branch Chief 

Fungicide Branch 

Registration Division (7505P) 

BASF is seeking to register metrafenone for use on Pome Fruit and Fruiting Vegetables. IR-4 has 

requested uses ofmetrafenone on Peach Subgroup 12-12B, Apricot, Cherry Subgroup 12-12A, Cucurbit 

Vegetables (Group 9), and Fruit, Small, Vine Climbing (except Fuzzy Kiwifruit) Subgroup 13~07F to 

control powdery mildew. These new uses are proposed on the Vivando Fungicide label (EPA Reg. No. 

7969-284). 
2

The PRZM EXAMS Tier II screening level concentrations in surface water for total metrafenone residues 

in drinking water for use in the human health dietary risk assessment are 25.64 μg/L for 1 in 10 year peak, 

14.52 μg/L for the 1 in 10 year annual average, and 9.22 μg/L for the 30 year annual average. Using 

PRZM-GW, total metrafenone residues in groundwater are not expected to exceed 12.5 μg/L for the peak 

EDWC and 12.3 μg/L for the post-breakthrough concentration (current use on grape). 

Total Toxic Residue Approach 

An analysis of the residues of concern for metrafenone indicate that the only identified major degradation 

product is CL 377160 [Methanone, (3-bromo-6-methoxy-2-methylphenyl)(3-hydroxy-2,4-dimethoxy-6-

methylphenyl)-]. This degradation product was detected in soil photolysis and anaerobic aquatic 

metabolism studies. Most degradation processes also resulted in formation of a substantial amount of 

minor degradates, some individually measured and identified, but most were not. Although all of these 

degradates were present at less than 10%, and some at very low levels, these residues may be of exposure 

concern. In some cases minor degradates, mostly unidentified, make up more than 50% of the applied 

radioactivity in a single sampling event. In addition, based on the structure of the parent compound and 

the proposed degradation pathways, many of the minor degradates may have a high degree of structural 

similarity to each other and/or the parent resulting in a similar toxicity profile and cumulative effects. 

Because of the structural similarity of many degradation products with the parent compound as well as a 

high number of unidentified minor degradation products, this drinking water assessment (DWA) for 

metrafenone was conducted using a total toxic residues approach (TTR). The TTR consists of parent 

metrafenone, CL4084564, CL375228, CL377160, CL 377096, CL434223, CL377095,CL 1023424, CL 

3000402,TN, MB, DG, GF, and unidentified extractable residues (ROCKS Memorandum, 8/29/2009). 

This modeling approach was adopted to address uncertainties associated with tentative identification of 

degradation productions and inadequate identification of minor degradation products that may be of 

toxicological concern. This DWA includes estimated drinking water concentrations (EDWCs) for 

metrafenone as well as total extractable residues referred to collectively as total metrafenone residues. 

 

Modeling Results for Use in the Human Health Risk Assessment 

The peak EDWC for total metrafenone residues based on the proposed uses [Pome Fruits, Fruiting 

Vegetables, Peach Subgroup 12-12B, Apricot, Cherry Subgroup 12-12A, Cucurbit Vegetables (Group 9), 

and Fruit, Small, Vine Climbing (except Fuzzy Kiwifruit) Subgroup 13-07F] is higher than the peak 

EDWC for the current use on grapes (Table 1). However, the 1 in 10 year annual average and 30-year 

annual average EDWCs for the proposed new uses are lower than the EDWCs for the grape use. The 

PRZM-EXAMS Tier II screening level concentrations in surface water for total metrafenone residues in 

drinking water are 25.64 μg/L for 1 in 10 peak, 14.52 μg/L for the 1 in 10 year annual average, and 9.22 

μg/L for the 30 year annual average. Total metrafenone residues in groundwater using PRZM-GW 

modeling are 12.5 μg/L for the peak EDWC and 12.3 μg/L for the post-breakthrough concentration. 
3

Table 1: Tier II PRZM/EXAMS and Tier I PRZM-GW EDWCs for Total Metrafenone Residues in Drinking 

Water 

Models 

Uses 

1 in 10 year 30-year 

Annual 

Peak Average Annual 

Average 

PRZM/EXAMS 

Pome Fruits, Fruiting Vegetables, Peach Subgroup 12-12B, 

Apricot, Cherry Subgroup 12-12A, Cucurbit Vegetables 

(Group 9), and Fruit, Small, Vine Climbing (except Fuzzy 

Kiwifruit) Subgroup 13-07F 

25.64 7.25 5.71 

PRZM/EXAMS Grapes 23.71 14.52 9.22 

PRZM-GW All Uses 12.5 12.3 

Previous Drinking Water Assessments 

A previous DWA was conducted to support use of metrafenone on grapes (D355987). This DWA was 

conducted using a registrant proposed maximum application rate of 0.3 lb a.i./A with 6 applications, and 

a minimum application interval of 14 days. However, the current registered maximum use rate on grapes 

is 0.3 lb a.i./A with 3 applications, and a minimum application interval of 14 days. EDWCs for 

metrafenone and total metrafenone residues in groundwater and surface water are shown Tables 2 and 3. 

Table 2. Estimated Drinking Water Concentrations (μg/L) for Metrafenone Resulting from Use on Grapes 

Models Peak Annual Average 30-year Annual Average

Surface Water

EDWCs for Initially Proposed Use Rates on Grapes (0.3 lb a.i./A, 6 applications, 14-day interval) 

Tier I FIRST 42.10 4.03 NA 

Tier II PRZM/EXAMS 25.73 6.26 3.71 

SCI-GROW NA 

EDWCs for Registered Use Rates on Grapes (0.3 lb a.i./A, 3 applications, 14-day interval)

Tier II PRZM/EXAMS 16.79 3.26 2.12 

Table 3. Estimated Drinking Water Concentrations (μg/L) for Total Metrafenone Residues Resulting from 

Use on Grapes 

Models Peak Annual Average 30-year Annual Average

Surface Water

EDWCs for Initially Proposed Use Rates on Grapes (0.3 lb a.i./A, 6 applications, 14-day interval) 

Tier I FIRST 43.54 10.41 NA 

Tier II PRZM/EXAMS 39.11 22.82 15.03 

SCI-GROW 0.097 NA 

EDWCs for Registered Use Rates on Grapes (0.3 lb a.i./A, 3 applications, 14-day interval)

Tier II PRZM/EXAMS 23.71 14.52 9.22 
4

Use Information 

 

Application rates and frequency of application for the proposed and existing uses are shown in Table 4. 

The proposed application method is ground or aerial application. Although the label has recommendation 

for reducing spray drift, it does not stipulate a spray drift buffer or droplet size for the proposed uses. 

Table 4. Metrafenone Use Profile [Vivando Fungicide (EPA Reg. No. 7969-284)] 

Use 

Max. 

Single App. 

Rate 

(lb a.i./A) 

# of App. 

/ 

Season 

Seasonal Max. Rate 

(lb a.i./A) 

Minimum App. 

Interval (days) 

Proposed Crops and Application Rates 

Pome Fruit 0.3 3 0.9 7 

Fruiting Vegetable 0.3 3 0.9 7 

Peach Subgroup 12-12B 0.3 2 0.6 7 

Apricots 0.3 2 0.6 7 

Cherry Subgroup 12-12A 0.3 2 0.6 7 

Hops 0.3 2 0.6 7 

Cucurbits Vegetables (Group 9) 0.3 3 0.9 7 

Fruit, small, vine climbing Subgroup 

(13-07F) 0.3 3 0.9 7 

Registered Crop and Application Rate

Grapes 0.3 3 0.9 14 

Environmental Fate Assessment 

Metrafenone is a benzophenone chemical class that is expected to be slightly mobile. Its major routes of 

degradation are aqueous photolysis and aquatic metabolism, in both aerobic and anaerobic conditions. 

Soil metabolism is slow, with laboratory half-lives of 6 months to a year and accumulation over two years 

observed in field studies. In aquatic environments, the measured photolysis half-life was 6 days and 

metabolism in both aerobic and anaerobic occurred with half-lives of one to four weeks. 

Soil photolysis and anaerobic aquatic metabolism of benzophenone led to one major degradate, CL 

377160, and anaerobic aquatic metabolism also led to six other major degradates, but all were either 

unidentified or only tentatively identified. In addition, there were many minor degradates, which were 

formed at low levels individually but reached substantial amounts as groups. 

Total extractable residues of metrafenone (metrafenone TTR) are persistent in soil, aerobic aquatic 

metabolism, and anaerobic metabolism environments. Although parent metrafenone and metrafenone 

TTR are persistent in aerobic soil environments, parent metrafenone degrades rapidly in aerobic and 

anaerobic aquatic environments with subsequent formation of extractable unidentified degradation 

products. The inclusion of unidentified degradation products in the estimation of metrafenone TTR halflife is the reason for higher persistence of metrafenone TTR in aquatic environments. 

 
5

Mobility 

Batch equilibrium data on metrafenone suggest that the compound will sorb to organic surfaces and 

would be considered “slightly mobile” according to the FAO classification scheme (organic carbon 

partition coefficients range from 1,073 to 2,792 mg/kg soil). Also according to FAO classification, 

metrafenone’s solubility in water of 0.447 mg/L is considered “slightly soluble.” It showed low volatility 

from soil and water with <0.5% volatilization in any laboratory study, consistent with the vapor pressure 

of 1.15 x 10-6 mmHg. Therefore, dissipation in the environment is expected to occur predominantly via 

runoff of suspended soil and sediments to which metrafenone is adsorbed. Based on terrestrial field 

dissipation studies in the UK , metrafenone was detected at a soil depth of 20-30 cm after 2 years. 

In aquatic systems, partitioning of metrafenone to sediment occurred rapidly. In one anaerobic system, 

half of the applied metrafenone was detected in sediment on the first day, and in three other systems (one 

anaerobic, two aerobic), at least 50% of the parent compound had partitioned to sediment within three to 

seven days. Including degradates, partitioning was rapid in anaerobic systems but slower in aerobic 

systems. In two anaerobic aquatic metabolism studies, more than half of the applied radioactivity (AR) 

was found in sediment within one week and radioactivity in the water layer was down to <5% AR in two 

to six weeks. However, in aerobic aquatic metabolism studies in two systems, from 8% to 28% AR 

remained in the water layer at study termination (100 days). 

Degradation Rates 

Metrafenone biodegrades slowly in terrestrial environments. In laboratory studies in a variety of soils, 

aerobic soil metabolism linear half-lives ranged from 178 to 365 days. In four of the eight soils tested, 

data collection extended long enough to determine a DT50, of 124 to 188 days in two silt loam soils and 

272 to 362 days in a clay loam and sandy loam soil. In these two soils, metabolism appeared to slow after 

272 days. No data are available for anaerobic soil metabolism rates. Photolysis on soil was observed in 

laboratory studies to occur with a linear half-life of 31 days. 

In aquatic environments, metrafenone biodegrades in weeks to months in both aerobic and anaerobic 

conditions (linear half-lives of 24-27 days and 18-22 days, respectively). Considering abiotic 

degradation, metrafenone is photolyzed in water (half-life of 8.4 days), but is stable to hydrolysis at pH 

values from 4 to 9. 

Degradation Products 

The only positively identified major degradate of metrafenone was CL 377160 [Methanone, (3-bromo-6-

methoxy-2-methylphenyl)(3-hydroxy-2,4-dimethoxy-6-methylphenyl)-]. CL 377160 was formed through 

soil photolysis at up to 18.9% AR and through anaerobic aquatic metabolism at up to 10.8% AR in the 

total system. It was also formed as a minor degradate through aquatic photolysis and aerobic aquatic 

metabolism. 

In one anaerobic aquatic metabolism study, another six degradates were formed at >9%, but these were 

either unidentified or only tentatively identified. These included TN (tentatively identified as a lactone 

compound; maximum 3.3%, 26.9% and 28.0% in the water layer, sediment and total system, 

respectively), MB (tentatively identified as a hydroxylation product of TN; maximum 1.1%, 11.6% and 

11.7% in the water layer, sediment and total system, respectively), and four unidentified degradates 

formed in the total system at 9.3% to 13% AR. 
6

Carbon dioxide was also a major degradate, formed through aquatic photolysis at up to 25% AR and 

through all other measured processes as a minor degradate. 

Most processes also resulted in formation of a substantial amount of minor degradates, some individually 

measured and identified, but most not. Although all of these degradates were present at less than 10%, 

and some at very low levels, they still may be of exposure concern because of the large overall amounts. 

In some cases minor degradates, mostly unidentified, make up more than 50% of the applied radioactivity 

in a single sampling event. In addition, based on the structure of the parent compound and the proposed 

degradation pathways, many of the minor degradates may have a high degree of structural similarity to 

each other and/or the parent and so may have cumulative effects. 

Exposure Modeling 

The estimated drinking water concentrations (EDWCs) were calculated using a Tier II surface water 

modeling (PRZM-EXAMS), and Tier I groundwater modeling (SCI-GROW and PRZM-GW). 

Appropriate input parameters for metrafenone and total metrafenone residues were selected from the 

physical/chemical properties and environmental fate data submitted by the petitionerto support the 

registration of metrafenone. Input parameters were selected in accordance with US EPA-OPP EFED 

water model parameter selection guidelines, Guidance for Selecting Input Parameters in Modeling the 

Environmental Fate and Transport of Pesticides, Version 2.01, October 22, 2009. Total metrafenone 

residue half-lives were calculated based on the total concentration (expressed as percent of applied 

radioactivity) of extractable residues present at each sampling interval for each of the relevant 

environmental fate studies (Appendix A). 

Additional information about the models, selection of input parameters and scenarios can be obtained 

from http://www.epa.gov /oppefed1/models/water/index.htm. 

Surface Water 

Scenarios used to run PRZM and EXAMS for the proposed new uses are shown in Table 6. Chemical 

specific input parameters used for modeling are shown in Table 5. The model EDWCs of metrafenone 

and total metrafenone residues for surface water are shown in Tables 7 and 8, respectively. The default 

Percent Crop Area (PCA) of 0.91 was used to correct the EDWCs [Echeverria, M., Jones, R. D., Peck, C., 

Ruhman, M., Shelby, A., Thawley, S., Thurman, N. Development and Use of Percent Cropped Area and 

Percent Turf Area Adjustment Factors in Drinking Water Exposure Assessments: 2012 Update, March 

16, 2012].
7

Table 5. PRZM/EXAMS Input Parameters for Metrafenone and Total Extractable Metrafenone Residue 

PARAMETER Metrafenone Total Extractable 

Metrafenone 

Residues 

COMMENT SOURCE 

Application Rate per 

Event 0.366 kg 

a.i./ha 0.366 kg a.i./ha 

Vivando 

Fungicide label 

(EPA Reg. No. 

7969-284)] 

No. of Applications 

 (Interval) 2 or 3 (7 day) 2 or 3 (7 day) 

CAM 

(Chemical App. 

Method) 

2 2 Broadcast spray 

Depth of Incorporation 0 0 Default 

Spray Drift Fraction / 

Application Efficiency 

0.064 / 0.99 

0.16/0.95 

0.064 / 0.99 

0.16/0.95 

Ground Spray 

Aerial Spray 

EFED Input 

Guidance

Aerobic Soil Metabolism 

t1/2

303 days 313 days 

Upper 90th percentile 

conference limit of the 

mean half-life (n=8) 

MRID 47267425 

MRID 47267426 

MRID 47267427 

Aerobic Aquatic 

Degradation t1/2 28.2 days 158 days 

Upper 90th percentile 

confidence limit of the 

mean half-life (n=2)

MRID 47267430 

Anaerobic Aquatic 

Degradation t1/2

25.3 days 989 days 

Upper 90th percentile 

confidence limit of the 

mean half-life (n=2) 

MRID 47267429 

MRID 47267431 

Aqueous Photolysis t1/2 6.4 days 27.0 days Corrected for dark 

control MRID 47267423 

Hydrolysis t1/2 0 days 0 days Stable MRID 47267422 

Soil Partition 

Coefficient (Koc) 2188 mL/goc 2188 mL/goc Average Koc MRID 47267420 

Molecular Weight 409 g/mole 409 g/mole MRID 47267423 

Water Solubility @ 

25°C 0.474 mg/L 0.474 mg/L MRID 47267423 

Vapor Pressure 1.15 x 10-6 

mmHg 1.15 x 10-6 mmHg EPA Fact Sheet 

(9/06) 

Percent Cropped Area 0.91 0.91 Default for 

agricultural crops 

 
8

Table 6. Scenarios Used for Surface Water Modeling

Agricultural Commodity Crop Scenario Met File First 

Application Date 

Pome Fruit 

PAappleSTD 

NCappleSTD 

WAorchardNMC 

CAfruitSTD 

W14751.dvf 

W03812.dvf 

W24243.dvf 

W93193.dvf 

5/15 

Fruiting Vegetable 

CAtomatoSTD 

FLtomatoSTD 

PAtomatoSTD 

W93193.dvf 

W12844.dvf 

W14751.dvf 

4/1 

3/1 

5/16 

Peach Subgroup 12-12B 

GApeachSTD W03813.dvf 5/15 

Apricots 

MIcherrySTD 

CAfruitSTD 

W14850.dvf 

W93193.dvf 

5/15 

Cherry Subgroup 12-12A 

MIcherrySTD W14850.dvf 5/15 

Hops 

ORhopsSTD W24232.dvf 5/1 

Cucurbits Vegetables (Group 9) 

MImelonSTD 

MOmelonSTD 

NJmelonSTD 

FLcucumber 

W94847.dvf 

W13893.dvf 

W13781.dvf 

W12844.dvf 

5/30 

5/10 

6/1 

11/16 

Fruit, small, vine climbing Subgroup (13-07F) 

NYgrapeSTD 

CAgrapeSTD 

CAwinegrapeSTD 

W14860.dvf 

W93193.dvf 

W23234.dvf 

7/1 

3/1 

4/1 

Estimated Drinking Water Concentrations (surface water) 

Tier II estimated drinking water concentrations for metrafenone and total metrafenone residues for the 

proposed crops are shown in Tables 7 and 8. 

 
9

Table 7. Percent Crop Area Corrected Estimated Exposure Concentrations for Parent Metrafenone Only 

from Surface Source Drinking Water 

Crop Scenario Application 

Method 

1-in-10 yr 

Peak

1-in-10 yr Annual 

Mean

30 year Annual 

Mean 

μg/L 

Pome Fruit PAapple Aerial 15.02 2.03 1.47 

Ground 13.39 1.87 1.28 

NC apple Aerial 22.54 2.42 1.48 

Ground 21.08 2.28 1.30 

WAorchard Aerial 4.65 0.95 0.68 

Ground 4.50 0.68 0.41 

CAfruit Aerial 4.35 0.75 0.56 

Ground 3.27 0.55 0.36 

Fruiting Vegetables CAtomato Aerial 5.90 0.82 0.57 

Ground 3.81 0.59 0.33 

FLtomato Aerial 18.92 2.38 1.72 

Ground 19.58 2.32 1.63 

PAtomato Aerial 18.49 1.99 1.51 

Ground 17.28 1.91 1.41 

Peach GApeach Aerial 3.19 0.37 0.31 

Ground 1.65 0.23 0.17 

Apricots MIcherry Aerial 5.09 1.17 0.86 

Ground 4.95 1.02 0.69 

CAfruit Aerial 3.21 0.50 0.38 

Ground 2.43 0.37 0.24 

Cherry Subgroup MIcherry Aerial 5.09 1.17 0.86 

Ground 4.95 1.02 0.69 

Hops ORhops Aerial 3.53 0.88 0.76 

Ground 3.02 0.71 0.58 

Cucurbits MImelon Aerial 7.95 1.60 1.21 

Ground 7.68 1.40 1.00 

MOmelon Aerial 16.17 1.81 1.30 

Ground 16.71 1.70 1.17 

NJmelon Aerial 19.96 2.48 1.48 

Ground 20.41 2.37 1.33 

Flcucumber Aerial 18.29 2.60 1.70 

Ground 19.01 2.54 1.60 

Fruit, small vine 

climbing Subgroup 

(13-07F) 

NYgrapes Aerial 15.27 3.08 2.09 

Ground 14.64 2.94 1.91 

CAgrapes Aerial 4.67 0.67 0.56 

Ground 2.51 0.38 0.28 

CAwinegrapes Aerial 5.23 0.95 0.70 

Ground 3.11 0.66 0.41 

 
10

Table 8. Percent Crop Area Corrected Estimated Exposure Concentrations for Metrafenone Total Residues 

from Surface Source Drinking Water 

Crop Scenario Application 

Method 

1-in-10 yr 

Peak

1-in-10 yr Annual 

Mean

30 year Annual 

Mean 

μg/L 

Pome Fruit PAapple Aerial 18.15 7.25 5.71 

Ground 16.05 6.52 4.93 

NC apple Aerial 25.64 7.23 5.07 

Ground 23.63 6.67 4.43 

WAorchard Aerial 8.16 4.63 3.82 

Ground 6.37 2.88 2.10 

CAfruit Aerial 7.39 3.48 2.97 

Ground 4.70 2.25 1.74 

Fruiting Vegetables CAtomato Aerial 7.99 3.24 2.58 

Ground 4.99 2.09 1.46 

FLtomato Aerial 22.45 5.33 3.98 

Ground 22.97 5.20 3.80 

PAtomato Aerial 20.05 7.51 5.90 

Ground 19.79 6.90 5.27 

Peach GApeach Aerial 9.39 2.31 1.74 

Ground 7.80 1.74 1.15 

Apricots MIcherry Aerial 9.21 5.27 3.97 

Ground 8.06 4.51 3.19 

CAfruit Aerial 5.22 2.32 1.98 

Ground 3.19 1.50 1.16 

Cherry Subgroup MIcherry Aerial 9.21 5.27 3.97 

Ground 8.06 4.51 3.19 

Hops ORhops Aerial 5.50 2.85 2.51 

Ground 4.24 2.20 1.87 

Cucurbits MImelon Aerial 11.97 5.87 4.73 

Ground 10.27 4.90 3.76 

MOmelon Aerial 19.13 4.71 3.63 

Ground 18.85 4.36 3.24 

NJmelon Aerial 23.85 6.90 4.83 

Ground 23.55 6.34 4.20 

Flcucumber Aerial 21.27 5.05 3.71 

Ground 21.20 4.91 3.51 

Fruit, small vine 

climbing Subgroup 

(13-07F) 

NYgrapes Aerial 22.98 12.85 9.32 

Ground 20.89 12.21 8.60 

CAgrapes Aerial 6.82 2.89 2.59 

Ground 3.77 1.57 1.29 

CAwinegrapes Aerial 7.09 3.08 2.50 

Ground 4.23 2.03 1.47 

 
11

Estimated Drinking Water Concentrations (ground water) 

SCI-GROW 

Concentration of total residues in groundwater were estimated using the Screening Concentration In 

Ground Water model(SCI-GROW) (Version 2.3). Input parameters for SCI-GROW modeling are shown 

in Table 9. Estimated concentrations of metrafenone and total metrafenone residues in groundwater are 

shown in Table 10. 

Table 9. SCI-GROW Input Parameters for Metrafenone and Total Extractable Metrafenone Residues

Model Parameter Value Reference 

Metrafenone

Koc (L/mg-OC) 2231 Median Koc 

Aerobic Soil Half-life (days) 303 days Upper 90th percentile of the mean 

Total Extractable Metrafenone Residues

Koc (L/mg-OC) 2231 Median Koc 

Aerobic Soil Half-life (days) 313 days Upper 90th percentile of the mean 

Table 10. Estimated Exposure Concentrations of Metrafenone and Total Metrafenone Residues in Drinking 

Water Drawn from Ground Water. 

Use Scenario Total Application Rate 

(lb ai/A) Total Residues Concentration (μg/L) 

Metrafenone 0.6 0.033 

0.9 0.049 

 Total Metrafenone Residues 0.6 0.034 

0.9 0.052 

PRZM-GW 

PRZM-GW modeling was conducted to estimate the concentrations of metrafenone and total metrafenone 

residues in groundwater. Input parameters for PRZM-GW modeling are shown in Table 11. The PRZMGW modeling was conducted to simulate 2 applications of 0.366 kg/ha (0.672 kg/ha) or 3 applications of 

0.366 kg/ha (1.008 kg/ha). 

Table 11. PRZM-GW Input Parameters for Metrafenone and Total Extractable Metrafenone Residues

Model Parameter Value Reference 

Metrafenone

Koc (L/mg-OC) 2188 Average Koc 

Aerobic Soil Half-life (days) 303 days Upper 90th percentile of the mean 

Hydrolysis Half-life (days) 0 (Stable) MRID 47267422 

Application Date May 15 First App Date 

Application Rate 0.336 kg/ha Maximum Single Application Rate 

Number of Applications 2 and 3 Proposed uses on label EPA Reg. No. 7969-284 

Application Interval 7 days Minimum Application Interval 

Total Extractable Metrafenone Residues

Koc (L/mg-OC) 2188 Average Koc 

Aerobic Soil Half-life (days) 313 days Upper 90th percentile of the mean 

Hydrolysis Half-life (days) 0 (Stable) MRID 47267422 

Application Date May 15 First App Date 

Application Rate 0.336 kg/ha Maximum Single Application Rate 

Number of Applications 2 and 3 Proposed uses on label EPA Reg. No. 7969-284 

Application Interval 7 days Minimum Application Interval 
12

Estimated drinking water concentrations for metrafenone and total metrafenone residues from PRZM-GW 

are shown in Tables 12 and 13 (Appendix C). The peak concentration from PRZM-GW represent the 

highest concentration of metrafenone residues in ground water. The post-breakthrough concentration 

represents the steady-state average metrafenone residues concentration in groundwater over the duration 

of the model simulation. Because metrafenone residue concentrations did not breakthrough into 

groundwater during a 30 year simulation, the PRZM-GW modeling was conducted using 100 year 

extended meteorological data. 

Table 12. PRZM-GW Estimated Exposure Concentrations of Metrafenone in Groundwater Source Drinking 

Water

Scenario 

Annual 

Application Rate 

(kg/ha) 

Peak 

Concentration 

(μg/L) 

Post Breakthrough 

Concentration 

(μg/L) 

Breakthrough 

Time 

(days) Comments 

FL Citrus 0.672 7.87 7.72 18172 100 years1

1.008 11.8 11.6 

GA 

Peanut 

0.672 0.52 NE2

No Breakthrough 100 years 1.008 0.79 NE 

MD Corn 0.672 3.78 3.31 18583 100 years 1.008 5.67 4.97 

NC 

Cotton 

0.672 2.43 2.3 18993 100 years 1.008 3.65 3.46 

WI Corn 0.672 4.83 4.82 36126 100 years 1.008 7.24 7.23 

FL Potato 0.672 0.00103 NE No Breakthrough 100 years 1.008 0.00154 NE 

1-100 year simulation with 100 years of application 

2-Not estimated because of no breakthrough into ground water 

Table 13. PRZM-GW Estimated Exposure Concentrations of Total Metrafenone Residues in Groundwater 

Source Drinking Water

Scenario 

Annual 

Application Rate 

(kg/ha) 

Peak 

Concentration 

(μg/L) 

Post Breakthrough 

Concentration 

(μg/L) 

Breakthrough 

Time 

(days) Comments 

FL Citrus 0.672 8.35 8.2 18172 100 years1

1.008 12.5 12.3 

GA 

Peanut 

0.672 0.59 NE2

No Breakthrough 100 years 1.008 0.88 NE 

MD Corn 0.672 4.16 3.64 18583 100 years 1.008 6.24 5.46 

NC 

Cotton 

0.672 2.71 2.57 18993 100 years 1.008 4.07 3.86 

WI Corn 0.672 5.24 5.28 36126 100 years 1.008 7.92 7.92 

FL Potato 0.672 0.00131 NE No Breakthrough 100 years 1.008 0.00195 NE 

1-100 year simulation with 100 years of application 

2-Not estimated because of no breakthrough into ground water 

 
13

Monitoring Data 

There are no groundwater or surface water monitoring data available for metrafenone and its degradation 

products. 

Uncertainties, Assumptions, and Limitations 

The proposed metrafenone label [Vivando Fungicide label (EPA Reg. No. 7969-284)] stipulates that the 

maximum application rates are on a seasonal basis instead of an annual basis. This assessment was 

conducted assuming that only a single cropping season occurs in a year. This assumption, however, may 

not be true for fruiting vegetable crops (FLtomato and Catomato) and cucurbits (FLcucumber) because of 

an extended growing season (e.g., more than one cropping season in a given year). Consideration of 

multiple seasons within a year is expected to increase the EDWCs. 

Another uncertainty in the assessment is the relative toxicity of numerous metrafenone degradation 

products with similar structures to parent metrafenone. To address this uncertainty, the drinking water 

assessment was conducted for parent metrafenone as well as TTR of metrafenone residues. This 

assessment approach provides a bounding level exposure estimate for metrafenone residues. 

 
14

APPENDIX A 

Total Extractable Metrafenone Residue Half-lives from Laboratory Degradation Studies 

Study Type MRID1 Half-life 

(days) 

Environmental Matrix Extractable Residues 

Aqueous 

Photolysis -23 27 Total Mass Balance - VOC - CO2

Soil Photolysis -24 47.8 Extractable Residues 

Aerobic Soil -27 169.1 sandy loam soil Extractable Residues 

Aerobic Soil -26 210.0 clay loam soil Extractable Residues 

Aerobic Soil -25 277.2 silty loam soil Extractable Residues 

Aerobic Soil -27 277.3 clay loam soil Extractable Residues 

Aerobic Soil -27 301.4 silt loam soil Extractable Residues 

Aerobic Soil -26 315.1 sandy loam soil Extractable Residues 

Aerobic Soil -27 330.1 silt loam soil Extractable Residues 

Aerobic Soil -26 364.8 loamy sand soil Extractable Residues 

Anaerobic 

Aquatic -29 182.0 DI water- silty clay loam Water + Total Extractable 

Anaerobic 

Aquatic -31 577.6 pond-sandy loam Water + Total Extractable 

Aerobic 

Aquatic -30 91.2 river-loam Water + Organic Extractable 

Aerobic 

Aquatic -30 123.8 pond-sand Total Mass Balance - VOC - CO2

1- Prefix MRID number is 472674- 
15

APPENDIX B 

PRZM EXAMS Sample Outputs 

NC Apple (Aerial)-Metrafenone TTR 

stored as NCapp.out 

Chemical: metrafenone 

PRZM environment: NCappleSTD.txt modified Tueday, 29 May 2007 at 13:58:16 

EXAMS environment: ir298.exv modified Tueday, 26 August 2008 at 06:14:08 

Metfile: w03812.dvf modified Tueday, 26 August 2008 at 06:14:10 

Water segment concentrations (ppb) 

Year Peak 96 hr 21 Day 60 Day 90 Day Yearly 

1965 7.394 7.008 6.254 5.371 4.742 2.109 

1966 10.95 10.42 9.153 7.574 7.469 4.437 

1967 20.32 19.28 16.55 13.6 12.14 6.727 

1968 13.48 12.88 11.05 9.737 9.59 6.248 

1969 16.7 15.87 13.22 10.23 8.911 5.756 

1970 7.819 7.524 6.716 5.616 5.771 4.439 

1971 9.711 9.27 7.973 6.872 6.496 4.077 

1972 22.82 21.56 17.45 13.35 11.35 5.912 

1973 30.91 29.8 24.87 18.69 17.11 8.858 

1974 10.08 9.744 8.811 8.347 8.275 6.197 

1975 16.97 16.14 13.48 10.35 9.09 5.583 

1976 27 25.61 21.23 16.95 14.63 7.557 

1977 9.404 9.064 8.451 7.685 7.186 5.976 

1978 12.19 11.66 10.09 8.159 7.277 5.368 

1979 9.764 9.345 8.669 7.263 6.8 4.719 

1980 10.18 9.736 8.245 7.777 7.037 4.267 

1981 25.79 24.56 20.38 15.1 12.64 6.15 

1982 12.27 11.76 10.84 8.991 8.791 5.856 

1983 8.613 8.273 7.551 6.383 5.692 4.289 

1984 9.573 9.125 7.701 7.188 7.125 4.449 

1985 13.24 12.59 10.55 7.917 6.856 4.48 

1986 10.75 10.25 8.844 7.153 6.473 4.584 

1987 38.43 36.28 30.26 22.47 18.72 9.094 

1988 9.492 9.186 8.317 7.146 6.766 5.925 

1989 15.94 15.23 13.22 10.92 9.765 5.665 

1990 14.96 14.46 12.4 10.05 9.498 6.059 

Sorted results 

Prob. Peak 96 hr 21 Day 60 Day 90 Day Yearly 

0.037037037037037 38.43 36.28 30.26 22.47 18.72 9.094 

0.0740740740740741 30.91 29.8 24.87 18.69 17.11 8.858 

0.111111111111111 27 25.61 21.23 16.95 14.63 7.557 

0.148148148148148 25.79 24.56 20.38 15.1 12.64 6.727 

0.185185185185185 22.82 21.56 17.45 13.6 12.14 6.248 

0.222222222222222 20.32 19.28 16.55 13.35 11.35 6.197 

0.259259259259259 16.97 16.14 13.48 10.92 9.765 6.15 

0.296296296296296 16.7 15.87 13.22 10.35 9.59 6.059 

0.333333333333333 15.94 15.23 13.22 10.23 9.498 5.976 

0.37037037037037 14.96 14.46 12.4 10.05 9.09 5.925 

0.407407407407407 13.48 12.88 11.05 9.737 8.911 5.912 

0.444444444444444 13.24 12.59 10.84 8.991 8.791 5.856 

0.481481481481481 12.27 11.76 10.55 8.347 8.275 5.756 

0.518518518518518 12.19 11.66 10.09 8.159 7.469 5.665 

0.555555555555556 10.95 10.42 9.153 7.917 7.277 5.583 

0.592592592592593 10.75 10.25 8.844 7.777 7.186 5.368 

0.62962962962963 10.18 9.744 8.811 7.685 7.125 4.719 

0.666666666666667 10.08 9.736 8.669 7.574 7.037 4.584 

0.703703703703704 9.764 9.345 8.451 7.263 6.856 4.48 

0.740740740740741 9.711 9.27 8.317 7.188 6.8 4.449 

0.777777777777778 9.573 9.186 8.245 7.153 6.766 4.439 

0.814814814814815 9.492 9.125 7.973 7.146 6.496 4.437 

0.851851851851852 9.404 9.064 7.701 6.872 6.473 4.289 

0.888888888888889 8.613 8.273 7.551 6.383 5.771 4.267 
16

0.925925925925926 7.819 7.524 6.716 5.616 5.692 4.077 

0.962962962962963 7.394 7.008 6.254 5.371 4.742 2.109 

0.1 28.173 26.867 22.322 17.472 15.374 7.9473 

 Average of yearly averages: 5.5685 

Inputs generated by pe5.pl - Novemeber 2006 

Data used for this run: 

Output File: NCapp 

Metfile: w03812.dvf 

PRZM scenario: NCappleSTD.txt 

EXAMS environment file: ir298.exv 

Chemical Name: metrafenone 

Description Variable Name Value Units Comments 

Molecular weight mwt 409 g/mol 

Henry's Law Const. henry atm-m^3/mol 

Vapor Pressure vapr 1.15E-6 torr 

Solubility sol 0.474 mg/L 

Kd Kd mg/L 

Koc Koc 2188 mg/L 

Photolysis half-life kdp 27 days Half-life 

Aerobic Aquatic Metabolism kbacw 158 days Halfife 

Anaerobic Aquatic Metabolism kbacs 989 days Halfife 

Aerobic Soil Metabolism asm 313 days Halfife 

Hydrolysis: pH 7 days Half-life 

Method: CAM 2 integer See PRZM manual 

Incorporation Depth: DEPI cm 

Application Rate: TAPP 0.336 kg/ha 

Application Efficiency: APPEFF 0.95 fraction 

Spray Drift DRFT 0.16 fraction of application rate applied to pond 

Application Date Date 15-5 dd/mm or dd/mmm or dd-mm or dd-mmm 

Interval 1 interval 7 days Set to 0 or delete line for single app. 

app. rate 1 apprate 0.336 kg/ha 

Interval 2 interval 7 days Set to 0 or delete line for single app. 

app. rate 2 apprate 0.336 kg/ha 

Record 17: FILTRA 

 IPSCND 1 

 UPTKF 

Record 18: PLVKRT 

 PLDKRT 

 FEXTRC 0.5 

Flag for Index Res. Run IR Reservoir 

Flag for runoff calc. RUNOFF total none, monthly or total(average of entire run) 

PA Apple (Aerial)-Metrafenone TTR 

stored as PAapp.out 

Chemical: metrafenone 

PRZM environment: PAappleSTD_V2.txt modified Tueday, 20 May 2008 at 13:00:22 

EXAMS environment: ir298.exv modified Tueday, 26 August 2008 at 06:14:08 

Metfile: w14751.dvf modified Tueday, 26 August 2008 at 06:15:00 

Water segment concentrations (ppb) 

Year Peak 96 hr 21 Day 60 Day 90 Day Yearly 

1961 8.419 7.986 6.922 6.23 5.613 2.591 

1962 7.218 6.939 6.419 5.621 5.195 4.184 

1963 7.77 7.476 6.581 5.527 5.052 4.176 

1964 8.338 8.031 7.378 6.474 6.05 4.608 

1965 7.739 7.449 6.666 5.683 5.236 4.144 

1966 15.32 14.61 12.37 9.647 8.653 5.086 

1967 12.03 11.68 10.52 9.432 8.752 6.767 

1968 14.97 14.57 12.57 9.822 8.665 6.668 

1969 23.98 22.83 19.68 14.9 12.96 7.869 

1970 11.42 11.07 10.33 9.74 9.383 7.386 

1971 13.19 12.65 10.83 9.234 8.282 6.224 

1972 61.41 58.12 47.17 33.42 28.14 13.6 

1973 18.04 17.51 15.74 13.45 12.4 10.96 

1974 11.08 10.79 9.984 9.344 8.828 7.922 
17

1975 17.75 17.05 14.74 11.91 10.71 7.974 

1976 11.95 11.54 10.41 8.87 8.482 7.385 

1977 9.392 9.094 8.228 7.279 6.69 5.652 

1978 11.35 10.92 9.752 8.125 7.692 5.466 

1979 9.348 9.014 8.077 7.095 6.553 5.505 

1980 9.247 8.908 8.03 6.618 5.906 4.603 

1981 8.28 7.993 7.128 6.389 6.287 4.913 

1982 20.16 19.37 18.39 14.77 12.87 7.061 

1983 11.16 10.78 9.873 8.145 7.31 5.702 

1984 16.45 15.77 13.82 12.38 10.98 6.961 

1985 10.37 10.04 9.143 7.825 7.111 5.771 

1986 10.45 10.09 9.043 7.592 6.982 5.603 

1987 9.626 9.284 8.123 7.438 6.838 5.742 

1988 8.928 8.626 7.743 6.522 6.457 5.19 

1989 10.56 10.25 9.173 8.592 8.285 5.738 

1990 17.83 17.06 14.37 11.26 10.13 6.841 

Sorted results 

Prob. Peak 96 hr 21 Day 60 Day 90 Day Yearly 

0.032258064516129 61.41 58.12 47.17 33.42 28.14 13.6 

0.0645161290322581 23.98 22.83 19.68 14.9 12.96 10.96 

0.0967741935483871 20.16 19.37 18.39 14.77 12.87 7.974 

0.129032258064516 18.04 17.51 15.74 13.45 12.4 7.922 

0.161290322580645 17.83 17.06 14.74 12.38 10.98 7.869 

0.193548387096774 17.75 17.05 14.37 11.91 10.71 7.386 

0.225806451612903 16.45 15.77 13.82 11.26 10.13 7.385 

0.258064516129032 15.32 14.61 12.57 9.822 9.383 7.061 

0.290322580645161 14.97 14.57 12.37 9.74 8.828 6.961 

0.32258064516129 13.19 12.65 10.83 9.647 8.752 6.841 

0.354838709677419 12.03 11.68 10.52 9.432 8.665 6.767 

0.387096774193548 11.95 11.54 10.41 9.344 8.653 6.668 

0.419354838709677 11.42 11.07 10.33 9.234 8.482 6.224 

0.451612903225806 11.35 10.92 9.984 8.87 8.285 5.771 

0.483870967741936 11.16 10.79 9.873 8.592 8.282 5.742 

0.516129032258065 11.08 10.78 9.752 8.145 7.692 5.738 

0.548387096774194 10.56 10.25 9.173 8.125 7.31 5.702 

0.580645161290323 10.45 10.09 9.143 7.825 7.111 5.652 

0.612903225806452 10.37 10.04 9.043 7.592 6.982 5.603 

0.645161290322581 9.626 9.284 8.228 7.438 6.838 5.505 

0.67741935483871 9.392 9.094 8.123 7.279 6.69 5.466 

0.709677419354839 9.348 9.014 8.077 7.095 6.553 5.19 

0.741935483870968 9.247 8.908 8.03 6.618 6.457 5.086 

0.774193548387097 8.928 8.626 7.743 6.522 6.287 4.913 

0.806451612903226 8.419 8.031 7.378 6.474 6.05 4.608 

0.838709677419355 8.338 7.993 7.128 6.389 5.906 4.603 

0.870967741935484 8.28 7.986 6.922 6.23 5.613 4.184 

0.903225806451613 7.77 7.476 6.666 5.683 5.236 4.176 

0.935483870967742 7.739 7.449 6.581 5.621 5.195 4.144 

0.967741935483871 7.218 6.939 6.419 5.527 5.052 2.591 

0.1 19.948 19.184 18.125 14.638 12.823 7.9688 

 Average of yearly averages: 6.2764 

Inputs generated by pe5.pl - Novemeber 2006 

Data used for this run: 

Output File: PAapp 

Metfile: w14751.dvf 

PRZM scenario: PAappleSTD_V2.txt 

EXAMS environment file: ir298.exv 

Chemical Name: metrafenone 

Description Variable Name Value Units Comments 

Molecular weight mwt 409 g/mol 

Henry's Law Const. henry atm-m^3/mol 

Vapor Pressure vapr 1.15E-6 torr 

Solubility sol 0.474 mg/L 

Kd Kd mg/L 

Koc Koc 2188 mg/L 

Photolysis half-life kdp 27 days Half-life 

Aerobic Aquatic Metabolism kbacw 158 days Halfife 
18

Anaerobic Aquatic Metabolism kbacs 989 days Halfife 

Aerobic Soil Metabolism asm 313 days Halfife 

Hydrolysis: pH 7 days Half-life 

Method: CAM 2 integer See PRZM manual 

Incorporation Depth: DEPI cm 

Application Rate: TAPP 0.336 kg/ha 

Application Efficiency: APPEFF 0.95 fraction 

Spray Drift DRFT 0.16 fraction of application rate applied to pond 

Application Date Date 15-5 dd/mm or dd/mmm or dd-mm or dd-mmm 

Interval 1 interval 7 days Set to 0 or delete line for single app. 

app. rate 1 apprate 0.336 kg/ha 

Interval 2 interval 7 days Set to 0 or delete line for single app. 

app. rate 2 apprate 0.336 kg/ha 

Record 17: FILTRA 

 IPSCND 1 

 UPTKF 

Record 18: PLVKRT 

 PLDKRT 

 FEXTRC 0.5 

Flag for Index Res. Run IR Reservoir 

Flag for runoff calc. RUNOFF total none, monthly or total(average of entire run) 

NYGrapes (Aerial)-14 day interval-Metrafenone TTR 

stored as NYgrap14.out 

Chemical: metrafenone 

PRZM environment: NYGrapesSTD.txt modified Tueday, 29 May 2007 at 13:59:44 

EXAMS environment: ir298.exv modified Tueday, 26 August 2008 at 06:14:08 

Metfile: w14860.dvf modified Tueday, 26 August 2008 at 06:15:12 

Water segment concentrations (ppb) 

Year Peak 96 hr 21 Day 60 Day 90 Day Yearly 

1961 4.708 4.531 3.816 3.078 2.77 1.229 

1962 21.36 20.51 17.66 14.37 13.22 6.133 

1963 12.37 12.01 10.99 9.9 9.267 8.137 

1964 25.64 24.71 21.56 17.46 15.77 9.72 

1965 14.64 14.26 13.6 12.74 12.25 10.4 

1966 17.55 17.02 15.23 12.9 11.93 9.529 

1967 15.5 15.15 14.21 13.25 12.61 9.39 

1968 10.92 10.61 9.69 9.015 8.628 7.702 

1969 9.548 9.275 8.464 7.845 7.332 6.444 

1970 18.21 17.53 16.64 14.57 14.31 8.589 

1971 15.74 15.29 14.18 12.62 11.96 9.804 

1972 13.1 12.77 11.91 11.09 10.69 8.977 

1973 11.9 11.59 10.51 9.163 8.77 7.457 

1974 13 12.62 11.44 9.963 9.263 7.27 

1975 21.97 21.34 19.52 16.51 15.18 10.15 

1976 13.12 12.79 12.1 11.36 11.21 9.781 

1977 25.86 25.34 24.06 21.2 19.89 12.04 

1978 26.08 25.3 23.17 20.55 19.27 14.55 

1979 27.01 26.27 23.83 21.64 20.82 15.29 

1980 31.12 30.2 27.03 23.83 22.2 16.59 

1981 19.37 19.08 17.77 16.51 15.92 14.27 

1982 17.21 16.76 15.32 13.83 13.2 11.69 

1983 25.42 24.61 23.12 19.7 18.4 12.04 

1984 18.34 17.88 16.39 14.26 13.3 11.51 

1985 14.91 14.52 13.44 12.03 11.19 10.13 

1986 19.18 18.54 17.58 14.73 13.58 10.1 

1987 23.7 22.91 20.38 19.3 18.2 12.24 

1988 20.49 19.87 17.73 16.28 15.55 12.31 

1989 14.68 14.31 13.09 12.31 11.69 10.38 

1990 21.31 20.64 19.51 16.86 15.66 10.33 

Sorted results 

Prob. Peak 96 hr 21 Day 60 Day 90 Day Yearly 

0.032258064516129 31.12 30.2 27.03 23.83 22.2 16.59 

0.0645161290322581 27.01 26.27 24.06 21.64 20.82 15.29 

0.0967741935483871 26.08 25.34 23.83 21.2 19.89 14.55 
19

0.129032258064516 25.86 25.3 23.17 20.55 19.27 14.27 

0.161290322580645 25.64 24.71 23.12 19.7 18.4 12.31 

0.193548387096774 25.42 24.61 21.56 19.3 18.2 12.24 

0.225806451612903 23.7 22.91 20.38 17.46 15.92 12.04 

0.258064516129032 21.97 21.34 19.52 16.86 15.77 12.04 

0.290322580645161 21.36 20.64 19.51 16.51 15.66 11.69 

0.32258064516129 21.31 20.51 17.77 16.51 15.55 11.51 

0.354838709677419 20.49 19.87 17.73 16.28 15.18 10.4 

0.387096774193548 19.37 19.08 17.66 14.73 14.31 10.38 

0.419354838709677 19.18 18.54 17.58 14.57 13.58 10.33 

0.451612903225806 18.34 17.88 16.64 14.37 13.3 10.15 

0.483870967741936 18.21 17.53 16.39 14.26 13.22 10.13 

0.516129032258065 17.55 17.02 15.32 13.83 13.2 10.1 

0.548387096774194 17.21 16.76 15.23 13.25 12.61 9.804 

0.580645161290323 15.74 15.29 14.21 12.9 12.25 9.781 

0.612903225806452 15.5 15.15 14.18 12.74 11.96 9.72 

0.645161290322581 14.91 14.52 13.6 12.62 11.93 9.529 

0.67741935483871 14.68 14.31 13.44 12.31 11.69 9.39 

0.709677419354839 14.64 14.26 13.09 12.03 11.21 8.977 

0.741935483870968 13.12 12.79 12.1 11.36 11.19 8.589 

0.774193548387097 13.1 12.77 11.91 11.09 10.69 8.137 

0.806451612903226 13 12.62 11.44 9.963 9.267 7.702 

0.838709677419355 12.37 12.01 10.99 9.9 9.263 7.457 

0.870967741935484 11.9 11.59 10.51 9.163 8.77 7.27 

0.903225806451613 10.92 10.61 9.69 9.015 8.628 6.444 

0.935483870967742 9.548 9.275 8.464 7.845 7.332 6.133 

0.967741935483871 4.708 4.531 3.816 3.078 2.77 1.229 

0.1 26.058 25.336 23.764 21.135 19.828 14.522 

 Average of yearly averages: 10.1394 

Inputs generated by pe5.pl - Novemeber 2006 

Data used for this run: 

Output File: NYgrap14 

Metfile: w14860.dvf 

PRZM scenario: NYGrapesSTD.txt 

EXAMS environment file: ir298.exv 

Chemical Name: metrafenone 

Description Variable Name Value Units Comments 

Molecular weight mwt 409 g/mol 

Henry's Law Const. henry atm-m^3/mol 

Vapor Pressure vapr 1.15E-6 torr 

Solubility sol 0.474 mg/L 

Kd Kd mg/L 

Koc Koc 2188 mg/L 

Photolysis half-life kdp 27 days Half-life 

Aerobic Aquatic Metabolism kbacw 158 days Halfife 

Anaerobic Aquatic Metabolism kbacs 989 days Halfife 

Aerobic Soil Metabolism asm 313 days Halfife 

Hydrolysis: pH 7 days Half-life 

Method: CAM 2 integer See PRZM manual 

Incorporation Depth: DEPI cm 

Application Rate: TAPP 0.336 kg/ha 

Application Efficiency: APPEFF 0.95 fraction 

Spray Drift DRFT 0.16 fraction of application rate applied to pond 

Application Date Date 1-7 dd/mm or dd/mmm or dd-mm or dd-mmm 

Interval 1 interval 14 days Set to 0 or delete line for single app. 

app. rate 1 apprate 0.336 kg/ha 

Interval 2 interval 14 days Set to 0 or delete line for single app. 

app. rate 2 apprate 0.336 kg/ha 

Record 17: FILTRA 

 IPSCND 1 

 UPTKF 

Record 18: PLVKRT 

 PLDKRT 

 FEXTRC 0.5 

Flag for Index Res. Run IR Reservoir 

Flag for runoff calc. RUNOFF total none, monthly or total(average of entire run) 
20

APPENDIX C 

PRZM-GW Metrafenone Total Residues- FL Citrus Scenario