### UNITED S T ATES ENV IRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460

March 4, 2015 OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION 

### Office of Pestici de Programs Registration Division (7505P )

MEMORANDUM DER for acu te toxi city st udies f or 1 00-RUAG Subject: Name ofthe Product Bicyclopyrone Wet Paste II 

### MUP EPA File Symbol: 100-RUAG DP Ba rco de 411851 De cis ion No 470871 Act ion Code: ROlO.O PC Code: 0 18986 From: .



# ~ Pnncess Campbell, DVM , MS , DACVPM

**~ ~**  

### CITAB \



## . (l. T hrou gh: John Redden , M.S.



### ~ 

## C· CITAB Registration Division (7505P) T o: Grant Rowland/Kat hryn Montague RM 23 Herbicide Branch Registration Division (7505P) Applicant: Syngenta Crop Protection, LLC. Greensboro , NC 27419 FORMULATION FROM LABEL: Active lng redient(s): Bicyclopyrone Other lngredient(s): Tota l: %by wt. 

### 89.6 10.4 100.0Bicyclopyrone Wet Paste II MUP Reviewer: Princess Campbell, DVM 

### BACKGROUND: Sy ngenta Crop Protecti on , LLC has submitted a set of six acute tox icit y studies to support the registration of Bic yc lop yrone Wet Paste II MUP, an herbi c ide. The tox icity stu di es were performed by RCC Ltd , Wolferstrasse 4, Switzerla nd, and the Safepharm Lab oratories betwe e n 2007 and 2008 (MRIDs 47841966 -71)
. Deficiencies: All studies are in compliance with EPA guidelines; any defic iency is not significant and does not affect the outcome of the stud y.
FINDINGS: All six studies have been classified as acceptable. The to xicology profile is as follows: Acute oral toxicity I V acceptab le Acute dermal toxici t y IV acceptable Acute inhalation IV acceptable Primary eye irritation IV acce ptable Prima ry dermal irritation IV acceptable Dermal sensitiza tion -ve acceptable

2 

### MRID 47841966 MRID 47841967 MRID 47841968 MRID 47841970 MRID 47841969 MRID 47841971Bicyclopyrone Wet Paste II MOP Reviewer: Princess Campbell, DVM


## LABEL:
PRODUCT ID 

### #: 

### 000100-01463 PRODUCT NAME: Bicyclopyrone Wet Paste II MUP PRECAUTIONARY STATEMENTS SIGNAL WORD: CAUTION Hazards to Humans and Domestic Animals: Wear: Long-s leeved shirt and long pants, Socks, Shoes, and gloves.

3Bicyclopyrone Wet Paste II MUP Reviewer: Princess Campbell, DVM
DER fi F"l S b 1100 RUAG or 1 e ,ym o 

## - l. DP BARCODE: 411851 2
. PC CODE: 018986 3. CURRENT DATE: February 4, 20 15 4. TEST ARTICLE: NOA449280; Batch #: SEZ 3AP006/ MILLED; Solid beige powder; Study/Species/Lab MRID Results Study #/Date Acute oral toxicity I rat 47841966 LD5o females is > 5000 mglkg mgl kg RCC Ltd /B35493 /07-05-2007 OCS PP 870.11 00; OECD 425

Acute dermal toxicity /rat 47841967 Dermal LDso Male s/females > 5000 I RCC Ltd 1835504 / 07-17-2007 mglkg bw OCSPP 870
. I200; OECD 402 Acute inhalation toxicity I rat 47841968 LC so Males and females > 5.210 mg/L RCC Ltd / B45145/ 05-08-2008 MMAD = 3.10 J.lm OCSPP 870.1300 ; OECD 403 GSD = 3.22 All survived exposure (nose onl y)
. Primary Skin irritation I rabbit 47841969 Non irritating RCC Ltd 1835515/ 05-11-2007 OCS PP 870 .24 00 ; OECD 404 Primary eye irritation I rabbit 47841970 Non irritating RCC Ltd 1835526 / 07-03-2007 OCSPP 8 7 0.2500; OECD 405 Dermal sensitization I mouse LLNA- 47841971 Negative. Safepharm Laboratories Ltd Positive control (15% HCA) : / 2364/ 005 3/ 01

- 08-2008 OCS PP 870 .2 600 Core Grade K ey: A = Acceptable, S = Sup pleme ntary, U =U nacceptable , D = Data Gap 

### ** Deta i led DER completed for acute toxicity studies (6 pack) in Global Joint Review format.

4 Tox Core Cat Grade IV A

IV A
IV A

IV A

IV A



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