P.1 

OAR Box 1111 

Prepped by Ryan Dugan 

Document Number: 

-1©e) M-A-1a1 

Docket Number: 

A-83-22 

Printed 4/15/2008 1:25:18 PM Sheet 106 of 118 
P.2 

•USB/ 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

Office of Air Quality Planning and Standards 

Research Triangle Park, North Carolina 27711 

Apri l 19, 1985 

MEMORANDUM 

SUBJECT: 

FROM: 

TO: 

Draft Lead Staff Paper \iO'C John R. O'Connor, Director 

Strategies and Air Standards (division 

CASAC Members 

V\tf ° 119& 

-"©&"" 

We would like to bring to your attention some additional substantive 

errors and omissions in the draft lead staff paper. The necessary 

corrections are listed below and are also being mailed to members of the 

public who have received the paper. 

Page 

IV-2 

VII-20 

C-l 

C-8 

Table 4-1 - In References column for "Soil," should read 

"See Table B£l_ and B-2." 

Figure 7-1 (attached) was not printed and should be inserted. 

3rd line: should read "(See Section V.A.I)" 

4th line: should read "... Section V.A.2..." 

Bottom line: should read "... used in Section V.A.I..." 

Table C-l (attached) was not printed and should be inserted. 

We hope these changes do not cause any inconvenience. Thanks again. 

Attachments 
fV 

RtOUtllO N Of 

HtM f _QO* POOL 

P.3 

IRYlMHOPOith C HI OUL10 

HtMOClOBlN 

SVftlHtSIS 

Ah [MIA HfOUCtD 

OXYGEN IRANSPOM 

10 A U tissues 

i AAUHuAllO * or 

NtPQAiC f f flClSO l 

OIHiRiTHlSSACfNI S 

CARDIOVASCULAR 

OTSfUHCIlO« ANO 

OTHtH HYPOXIC I f f(CH 

t f fECISON MuHUN S 

AXONS A. 0 

SCHftAM* C[LlS 

HtOUCtU H1M0PH0IUN S 

d i .crioCHfioMfs i 

IMPAlHEO 

CtllULA H 

INEHCMlCS 

iMPAihIUMVf UNAtiU M 

ANO ftfHVI CUMOUCHON 

IMPAlHIO DfVElOPNU N I 

Of Nt hVOuSSVSU M 

DISIUHUIO iMuNQ 

HILU t A1UHT HOIt 

0) CALCIUM 

IMPAIHI il MINIMAL 

llilU i KOMiOllAil S 

IMPAIHIO lONt AMO 

IOOI H OIVflOPMfli t 

HtNA i tNUOCKlNt 

HtOuCtO • 7S'0H ^ 

VHAMiN U h- 0IS1UM810 CAICIUM 

M l IAHOHSM 

IMPAIHIu CALCIUM 

H U I Ai l(CONU 

MISSthllf l 

OlSlUHBI C HOlf IN 

HJMQRQU NtSiS 

CONIHO l 

IMPAlHIO CALCIUM 

HOlf IN CYCLIC 

NUCLtOllOl* Mf lABQliSM 

HtUUCI UHIM I I UH 

M(Mf Ml LUI AH O 

IMANSUJhMAItllNS 

IMPAIKl U 

Ul lUfllHCANU N 

0* i t NUblUNCS 

IMPAlHIDM I MBOIIS M 

Uf INUOCINOUS 

AGONISTS 

IMPAIHI U Ui lUKIt ItAllO h 

Of INVIHONUINU l 

lUKih'j 

IMPAIHI U 

Of IfJXIIiCAhur. 

Ul DHULS 

ALlfH t OM ! IABC* ISM 

Of IHVPIOPMA N 

IMPAIHIU 

YUhOKYl AIiON 

Of IOHIIS0 1 

l i t VAIt D SHAIN 

I f VU S Of IHtPtOPHA N 

SfRQIONIN ANO Ml A A 

OlSlUfUtO INOOl l AMiNI 

NEUROTRANSMUTt ft 

FUNCHOft 

Figure 7-1. Multi-organ impact of reductions of heme body pool 

by lead. Impairment of heme synthesis by lead results in disruption 

of wide variety of important physiological Drocesses in many 

organs and tissues. Particularly well documented are erythropoietic, 

neural, renal-endocrine, and hepatic effects indicated above by 

solid arrows (—•*). Plausible further consequences of heme 

synthesis interference by lead which remain to be more conclusively established are indicated by dashed arrows (--»). 

Source: Criteria Document (Figure 13-4). 
P.4 

Table C-l. IMPACT OF DIFFERENT LEVELS OF LEAD UPTAKE ON 

BLOOD LEAD AS PREDICTED BY 2 COMPARTMENTAL MODELS 

AND COMPUTED BY HAMMOND ET AL. (1981, 1982) 

Total Pb 

Absorbed 

( ug/day) 

35.2 

70.4 

105.6 

140.8 

176.0 

211.2 

Aft 

PbB 

Be 

er 5 yr 

13.5 

30.5 

48.4 

66.7 

85.2 

103.9 

Predicted by 

rnard Model 

( ug/dl) 

After 19 yr. 

16.5 

34.2 

52.4 

70.9 

89.6 

108.3 

After 

PbB Predicted by 

Rabinowitz Model 

( ug/dl) 

5 yr. After 19 yr. 

13 

26 

39 

52 

65 

78 

14 

36 

45 

60 

76 

91