Federal Register / Vol. 83, No. 5 / Monday, January 8, 2018 / Notices 823 

have proven to be both highly antigenic 

and shown to be responsible in allowing 

malaria parasites to evade the mosquito 

immune system. Proof of concept in a 

mouse model has demonstrated that 

vaccination using specific P47 protein 

fragments blocks Plasmodium 

transmission by mosquitoes. 

Immunization with the P47 protein 

variants of this technology provides a 

candidate for a potential, effective, 

transmission blocking malaria vaccine 

against Plasmodium species. 

This technology is available for 

licensing for commercial development 

in accordance with 35 U.S.C. 209 and 37 

CFR part 404, as well as for further 

development and evaluation under a 

research collaboration. 

Potential Commercial Applications: 

• Transmission blocking malaria 

vaccine 

Competitive Advantages: 

• Transmission blocking of 

Plasmodium 

• Transmission blocking activity based 

on recruiting the mosquito immune 

system to kill Plasmodium parasites 

by blocking Plasmodium immune 

evasion 

Development Stage: 

• Early-stage 

• In vitro data available 

• In vivo data available (animal) 

Inventors: Carolina Veronica BarillasMury, Alvaro Molina-Cruz, Gaspar 

Exequiel Canepa, all of NIAID. 

Publications: 

Intellectual Property: HHS Reference 

No. E–294–2016/0—U.S. Provisional 

Application No. 62/463,011, filed 

February 24, 2017. 

Licensing Contact: Peter Tung, 240– 

669–5483; peter.tung@nih.gov. 

Collaborative Research Opportunity: 

The National Institute of Allergy and 

Infectious Diseases is seeking statements 

of capability or interest from parties 

interested in collaborative research to 

further develop, evaluate or 

commercialize P47 protein fragments as 

a transmission blocking vaccine. For 

collaboration opportunities, please 

contact Peter Tung at 240–669–5483; 

peter.tung@nih.gov. 

Dated: December 13, 2017. 

Suzanne Frisbie, 

Deputy Director, Technology Transfer and 

Intellectual Property Office, National Institute 

of Allergy and Infectious Diseases. 

[FR Doc. 2018–00121 Filed 1–5–18; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

Interagency Coordinating Committee 

on the Validation of Alternative 

Methods Communities of Practice 

Webinar on Machine Learning in 

Toxicology: Fundamentals of 

Application and Interpretation; Notice 

of Public Webinar; Registration 

Information 

AGENCY: National Institutes of Health, 

HHS. 

ACTION: Notice. 

SUMMARY: The Interagency Coordinating 

Committee on the Validation of 

Alternative Methods (ICCVAM) 

announces a public webinar ‘‘Machine 

Learning in Toxicology: Fundamentals 

of Application and Interpretation.’’ The 

webinar is organized on behalf of 

ICCVAM by the National Toxicology 

Program Interagency Center for the 

Evaluation of Alternative Toxicological 

Methods (NICEATM). Interested persons 

may participate via WebEx. Time will 

be allotted for questions from the 

audience. 

DATES: Webinar: January 23, 2018, 1:00 

p.m. to approximately 2:30 p.m. Eastern 

Standard Time (EST). Registration for 

the Webinar: December 18, 2017, until 

2:30 p.m. on January 23, 2018. 

ADDRESSES: Webinar web page: http://

ntp.niehs.nih.gov/go/commprac-2018. 

FOR FURTHER INFORMATION CONTACT: Dr. 

Warren Casey, Director, NICEATM; 

telephone: (984) 287–3118; email: 

warren.casey@nih.gov. 

SUPPLEMENTARY INFORMATION: 

Background: ICCVAM promotes the 

development and validation of toxicity 

testing methods that protect human 

health and the environment while 

replacing, reducing, or refining animal 

use. ICCVAM also provides guidance to 

test method developers and facilitates 

collaborations that promote the 

development of new test methods. To 

address these goals, ICCVAM will hold 

a Communities of Practice webinar on 

‘‘Machine Learning in Toxicology: 

Fundamentals of Application and 

Interpretation.’’ 

The ICCVAM webinar will explore 

the fundamentals of machine learning 

approaches, including how they work, 

how they are interpreted, and 

precautions that should be taken when 

evaluating their output. It will feature 

presentations by two experts in use of 

machine learning in toxicity texting 

applications that will address issues 

specific to use of machine learning 

approaches in a regulatory context. Case 

studies will be presented to highlight 

where such techniques have been 

successfully applied both nationally and 

internationally. The preliminary agenda 

and additional information about 

presentations will be posted at http://

ntp.niehs.nih.gov/go/commprac-2018 as 

available. 

Webinar and Registration: This 

webinar is open to the public with time 

scheduled for questions by participants 

following each presentation. 

Registration for the webinar is required 

and is open through 2:30 p.m. on 

January 23, 2018. Registration is 

available at http://ntp.niehs.nih.gov/go/ 

commprac-2018. Interested individuals 

are encouraged to visit this web page to 

stay abreast of the most current webinar 

information. Registrants will receive 

instructions on how to access and 

participate in the webinar in an email 

sent shortly before the webinar. 

Individuals with disabilities who 

need accommodation to participate in 

this event should contact Elizabeth 

Maull at phone: (984) 287–3157 or 

email: maull@niehs.nih.gov. TTY users 

should contact the Federal TTY Relay 

Service at (800) 877–8339. Requests 

should be made at least five business 

days in advance of the event. 

Background Information on ICCVAM 

and NICEATM: ICCVAM is an 

interagency committee composed of 

representatives from 16 federal 

regulatory and research agencies that 

require, use, generate, or disseminate 

toxicological and safety testing 

information. ICCVAM conducts 

technical evaluations of new, revised, 

and alternative safety testing methods 

and integrated testing strategies with 

regulatory applicability and promotes 

the scientific validation and regulatory 

acceptance of testing methods that more 

accurately assess the safety and hazards 

of chemicals and products and replace, 

reduce, or refine (enhance animal wellbeing and lessen or avoid pain and 

distress) animal use. 

The ICCVAM Authorization Act of 

2000 (42 U.S.C. 285l–3) establishes 

ICCVAM as a permanent interagency 

committee of the National Institute of 

Environmental Health Sciences and 

provides the authority for ICCVAM 

involvement in activities relevant to the 

development of alternative test 

methods. ICCVAM acts to ensure that 

new and revised test methods are 

validated to meet the needs of federal 

agencies, increase the efficiency and 

effectiveness of federal agency test 

method review, and optimize utilization 

of scientific expertise outside the federal 

government. Additional information 


sradovich on DSK3GMQ082PROD with NOTICES
824 Federal Register / Vol. 83, No. 5 / Monday, January 8, 2018 / Notices 

about ICCVAM can be found at http:// 

ntp.niehs.nih.gov/go/iccvam. 

NICEATM administers ICCVAM, 

provides scientific and operational 

support for ICCVAM-related activities, 

and conducts and publishes analyses 

and evaluations of data from new, 

revised, and alternative testing 

approaches. NICEATM and ICCVAM 

work collaboratively to evaluate new 

and improved testing approaches 

applicable to the needs of U.S. federal 

agencies. NICEATM and ICCVAM 

welcome the public nomination of new, 

revised, and alternative test methods 

and strategies for validation studies and 

technical evaluations. Additional 

information about NICEATM can be 

found at http://ntp.niehs.nih.gov/go/ 

niceatm. 

Dated: December 20, 2017. 

John R. Bucher, 

Associate Director, National Toxicology 

Program. 

[FR Doc. 2018–00120 Filed 1–5–18; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HOMELAND 

SECURITY 

U.S. Customs and Border Protection 

[1651–0007] 

Agency Information Collection 

Activities: Application for Allowance in 

Duties 

AGENCY: U.S. Customs and Border 

Protection (CBP), Department of 

Homeland Security. 

ACTION: 60-Day notice and request for 

comments; extension of an existing 

collection of information. 

SUMMARY: The Department of Homeland 

Security, U.S. Customs and Border 

Protection will be submitting the 

following information collection request 

to the Office of Management and Budget 

(OMB) for review and approval in 

accordance with the Paperwork 

Reduction Act of 1995 (PRA). The 

information collection is published in 

the Federal Register to obtain comments 

from the public and affected agencies. 

Comments are encouraged and will be 

accepted (no later than March 9, 2018) 

to be assured of consideration. 

ADDRESSES: Written comments and/or 

suggestions regarding the item(s) 

contained in this notice must include 

the OMB Control Number 1651–0007 in 

the subject line and the agency name. 

To avoid duplicate submissions, please 

use only one of the following methods 

to submit comments: 

(1) Email. Submit comments to: CBP_

PRA@cbp.dhs.gov. 

(2) Mail. Submit written comments to 

CBP Paperwork Reduction Act Officer, 

U.S. Customs and Border Protection, 

Office of Trade, Regulations and 

Rulings, Economic Impact Analysis 

Branch, 90 K Street NE, 10th Floor, 

Washington, DC 20229–1177. 

FOR FURTHER INFORMATION CONTACT: 

Requests for additional PRA information 

should be directed to Seth Renkema, 

Chief, Economic Impact Analysis 

Branch, U.S. Customs and Border 

Protection, Office of Trade, Regulations 

and Rulings, 90 K Street NE, 10th Floor, 

Washington, DC 20229–1177, 

Telephone number (202) 325–0056 or 

via email CBP_PRA@cbp.dhs.gov. Please 

note that the contact information 

provided here is solely for questions 

regarding this notice. Individuals 

seeking information about other CBP 

programs should contact the CBP 

National Customer Service Center at 

877–227–5511, (TTY) 1–800–877–8339, 

or CBP website at https:// 

www.cbp.gov/. 

SUPPLEMENTARY INFORMATION: CBP 

invites the general public and other 

Federal agencies to comment on the 

proposed and/or continuing information 

collections pursuant to the Paperwork 

Reduction Act of 1995 (44 U.S.C. 3501 

et seq.). This process is conducted in 

accordance with 5 CFR 1320.8. Written 

comments and suggestions from the 

public and affected agencies should 

address one or more of the following 

four points: (1) Whether the proposed 

collection of information is necessary 

for the proper performance of the 

functions of the agency, including 

whether the information will have 

practical utility; (2) the accuracy of the 

agency’s estimate of the burden of the 

proposed collection of information, 

including the validity of the 

methodology and assumptions used; (3) 

suggestions to enhance the quality, 

utility, and clarity of the information to 

be collected; and (4) suggestions to 

minimize the burden of the collection of 

information on those who are to 

respond, including through the use of 

appropriate automated, electronic, 

mechanical, or other technological 

collection techniques or other forms of 

information technology, e.g., permitting 

electronic submission of responses. The 

comments that are submitted will be 

summarized and included in the request 

for approval. All comments will become 

a matter of public record. 

Overview of This Information 

Collection 

Title: Application for Allowance in 

Duties. 

OMB Number: 1651–0007. 

Form Number: CBP Form 4315. 

Action: CBP proposes to extend the 

expiration date of this information 

collection with no change to the burden 

hours or to Form 4315. 

Type of Review: Extension (without 

change). 

Abstract: CBP Form 4315, 

‘‘Application for Allowance in Duties,’’ 

is submitted to CBP in instances of 

claims of damaged or defective 

imported merchandise on which an 

allowance in duty is made in the 

liquidation of the entry. The 

information on this form is used to 

substantiate an importer’s claim for 

such duty allowances. CBP Form 4315 

is authorized by 19 U.S.C. 1506 and 

provided for by 19 CFR 158.11, 158.13 

and 158.23. This form is accessible at: 

http://www.cbp.gov/sites/default/files/ 

documents/CBP%20Form%204315_

0.pdf. 

Affected Public: Businesses. 

Estimated Number of Respondents: 

12,000. 

Estimated Number of Total Annual 

Responses: 12,000. 

Estimated Time per Response: 8 

minutes. 

Estimated Annual Burden Hours: 

1,600. 

Dated: January 2, 2018. 

Seth Renkema, 

Branch Chief, Economic Impact Analysis 

Branch, U.S. Customs and Border Protection. 

[FR Doc. 2018–00071 Filed 1–5–18; 8:45 am] 

BILLING CODE 9111–14–P 

DEPARTMENT OF HOMELAND 

SECURITY 

U.S. Customs and Border Protection 

[1651–0127] 

Agency Information Collection 

Activities: Guarantee of Payment 

AGENCY: U.S. Customs and Border 

Protection (CBP), Department of 

Homeland Security. 

ACTION: 60-Day notice and request for 

comments; extension of an existing 

collection of information. 

SUMMARY: The Department of Homeland 

Security, U.S. Customs and Border 

Protection will be submitting the 

following information collection request 

to the Office of Management and Budget 

(OMB) for review and approval in 

accordance with the Paperwork 


sradovich on DSK3GMQ082PROD with NOTICES