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# OAR Box 

# 1111 Prepped by Ryan Dugan



## Document

Number: 

# -1©e ) M-A-1a1 Docket Number: 

# A-83-2 2

Printed 4/15/20081:25:18PM

Sheet 106 of 118P. 2


# •USB / UNITE D STATE S ENVIRONMENTA L PROTECTIO N AGENC Y

Offic e o fAi rQualit yPlannin g an d Standard s Researc h Triangl e Park , Nort h Carolin a 2771 1

Apri l 19 , 198 5



### MEMORANDU

M SUBJECT : FROM :
TO : Draf t Lea dStaf f Pape r 

# \iO'C

Joh n R
. O'Connor , Directo r Strategie s an d Ai rStandard s (divisio n 

### CASA C Member s 

# V\t f 

# ° 119 &



# -"©&" "

We woul dlik e t o brin g t o you r attentio nsome additiona l substantiv e error s an

domission s i nth e draf t leadstaf f paper . Th e necessar y correction s ar e liste dbelow an dar e als o bein g maile dt o member s o f th e publi c wh o hav e receive dth e paper . Pag e IV- 2
VII-2 0 C- l

C- 8 Tabl e 4- 1 - I nReference s colum nfo r "Soil, " shoul dread "Se e Tabl e B£l

_an dB-2. " Figur e 7- 1 (attached ) wa s no t printe dan dshoul db e inserted . 3rdline : shoul dread"(Se e SectionV.A.I) " 4t hline : shoul dread".. . Sectio nV.A.2... " Bottom line : shoul dread".. . use di nSectionV.A.I... " Tabl e C- l (attached ) wa s no t printe dan dshoul db e inserted . We hop e thes e change s d o no t caus e an y inconvenience . Thank s again . Attachment sf V

RtOUtllO N O f HtM f_QO * POO L P. 3

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### Figur e 7-1 . Multi-orga n impac t o f reduction s o f hem e bodypoo l b ylead . Impairmen t o f hem e synthesi s b ylea d result s i n disruptio n o f wid e variet yo f importan t physiologica l Drocesse s i n man y organ s an d tissues . Particularl ywel l documente d ar e erythropoietic , neural , renal-endocrine , an d hepati c effect s indicate d abov e b y soli d arrow s (—•*) . Plausibl e furthe r consequence s o f hem e synthesi s interferenc e b ylea d whic hremai n t o b e mor e conclu

sivel yestablishe d ar e indicate d b ydashe d arrow s (--») . Source : Criteri a Documen t (Figur e 13-4) .P. 4



### Tabl e C-l . IMPAC T O F DIFFEREN T LEVEL S O F LEAD UPTAK E ON BLOO D LEAD A S PREDICTE D BY 2 COMPARTMENTA L MODEL S AN D COMPUTE D BY HAMMON D E T AL . (1981 , 1982 )

Tota l P b Absorbe d ( ug/day ) 35. 2 70. 4 105. 6 140. 8 176. 0 211. 2 

### Af t Pb B Be e r 5 y r 13. 5 30. 5 48. 4 66. 7 85. 2 103. 9 Predicte d b

y rnar d Mode l ( ug/dl ) Afte r 1 9 yr . 16. 5 34. 2 52. 4 70. 9 89. 6 108. 3 Afte r Pb B Predicte d b

y Rabinowit z Mode l ( ug/dl ) 5 yr. Afte r 1 9 yr . 

### 1 3 2 6 3 9 5 2 6 5 7 8 1 4

3 6 4 5 6 0 7 6 9 1