### UNITED STATES ENVIRONMENT AL PROTECTION AGENCY

MEMORANDUM

Date: February 25, 2016 WASHINGTON, D.C. 20460

OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION



### SUBJECT: Fluazinam Acute and Chronic Aggregate Dietary (Food and Drinking Water) Exposure and Risk Assessments for the Section 3 Registration Action for New Uses on Tuberous and Corm

, Subgroup IC

, Mayhaw, Squash/Cucumber Subgroup 9B; Amended Uses on Cabbage; and Removal of Cabbage from Vegetable

, 

### Brassica leafy, group 5.

PC Code: 129098 Decision Nos.: 499960

, 502449 Petition: 5E8349 Risk Assessment Type: Dietary TXRNo.: NA MRIDNo.: NA DP Barcode: D429506 Registration No.: 71512-1 Regulatory Action: Section 3 Registration Case No.: 7013 CAS No.: 79622-59-6 40 CFR: §180.574

FROM: Elizabeth Holman

, DrPH

, Physical Scientist Risk Assessment Branch II Health Effects Division (7509P)

THROUGH: Kristin Rury

, MPH

, Biologist 

# y__ 

# Q**~** Julie Van Alstine

, MPH

,

## Environme~t;l**~h** Scientist Dietary Exposure Science Advisory Council

TO: Andrew Ertman/Barbara Madden

, Minor Use Team Risk Integration Minor Use

, and Emergency Response Branch Registration Division (7505P)

Executive Summary

Acute and chronic aggregate dietary [food and drinking water] exposure and risk assessments

were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM-FCID) Version 3.16. This software uses 2003-2008 food consumption data from the U.S. Department of Agriculture 's (USDA's) National Health and

Page I of 17Fluazinam Dietary Exposure and Risk Assessme nt DP Number: D429506

Page 2 of 17 

### Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA). The analyses were conducted as part of a human health ri sk assessment for the proposed new uses of fluazinam on tuberous and corm vegetables, Subgroup 1C; Mayhaw; Squash/Cucumber Subgroup 9B; an amended use on cabbage; and removal of cabbage from vegetable, Brassica leafy, group 5. The estimated drinking water con centrations (EDWCs) are based on a currently registered use on turf. This memorandum was re viewed by two peer reviewers of the DESAC, per DESAC SOP 2012.1.

The acute analysis is based on tolerance-leve l residues for all commodities and uses high-end residue estimates for the metabolite AMGT. In addition, the acute assessment assumes 100% crop treated and incorporates modeled EDWCs th at account for both parent fluazinam and its transformation products. Therefore, the resulting exposure and risk estimates are considered to be very conservative. The acu te risk estimates at the 95 th 

### percentile of exposure are below HED’s level of concern for all population subgrou ps, including those comprised of infants andchildren. Generally, HED is concerned when risk estimates exceed 100% of the populationadjusted dose (PAD). The acute risk estimate fo r the General U.S. Population is 5.7% of the acute PAD (aPAD). The aPAD is lower for fema les 13 to 49 years old. Although Children 1-2 years old have the highest exposure estimat e (0.112064 mg/kg/day; 22% aPAD), the population subgroup with the highest risk estimate is female s 13 to 49 years old, which utilizes 32% of the aPAD (0.022220 mg/kg/day).

The chronic analysis is based on tolerance-level residues for all commodities except apples. For apples, the average field trial value was used. As with the acute assessment, it assumes high-end estimates for AMGT, 100% crop treated, and inco rporates modeled EDWCs that account for both parent and transformation products. The resulting exposure and risk estimates are considered to be conservative. Chronic risk es timates are below HED’s level of concern for all population subgroups. The risk estimate for the Ge neral U.S. Population is 41% of the chronic PAD (cPAD). The most highly exposed population subgroup is All Infants, which uses 92% of the cPAD.

Fluazinam is classified as having “suggestive evidence of carcinogenicity , but not sufficient to assess human carcinogenic potential.” The CARC dete rmined that quantification of risk using a non-linear approach (i.e., RfD) will adequately account for all chroni c toxicity, including carcinogenicity, that could result from exposure to fluazinam. As a result, the chronic dietary exposure assessment is protective for potential cancer risk.

I. Introduction

Dietary risk assessment incorporat es both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expresse d as a percentage of a maximum acceptable dose (i.e., the dose that HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the population-adjust ed dose (PAD). The PAD is equivalent to the point of departure (POD, e.g. no observed adve rse effect level (NOAEL), lowest observed adverse effect level (LOAEL)) divided by the required uncertainty or safety factors.Fluazinam Dietary Exposure and Risk Assessme nt DP Number: D429506

Page 3 of 17 

### For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. References that disc uss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, web link: http://www.regulations.gov/#!docum entDetail;D=EPA-HQ-OPP-2007-0780-0001 ; or see SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment fo r fluazinam was conducted by D. Dotson (D397722, 9/7/2012).

II. Residue Information

Fluazinam is currently registered in the U.S. for use on a number of crops, including carrots, melon (subgroup 9A), potatoes, ginseng, the Bulb onion subgroup (3-07A), head lettuce, leaf lettuce, Crop Group 5 ( Brassica leafy vegetables), turnip greens, peanuts, apples, the Bushberry subgroup (13-07B), and Crop subgro ups 6-A (except pea), 6-B (except pea), and 6-C (except pea). In addition, there is a tolerance without U. S. registration on wine grapes. Tolerances for these commodities range from 0.01 ppm to 7.0 ppm. Tolerances have also been established for residues in the fat and meat bypr oducts of cattle, goats, horses, a nd sheep. The tolerances for fluazinam are listed in 40 CFR 180.574.

The metabolite AMGT is a residue of concern for some commodities, but not for others. In the crop field trials that were pe rformed, AMGT was measured in some commodities but not in others. As a result, the residue levels that were used in the dietary exposure assessments were determined in different ways. The residue of concern for risk assessment in peanuts, bulb vegetables, and root and tuber vegetables is pare nt fluazinam. For all other plant commodities, the residues of concern in plants for risk as sessment are fluazinam and its metabolite AMGT. Table 1 summarizes the residue input values us ed in the acute and chronic assessments.

As the residue of concern in peanuts, bulb vegeta bles, and root and tuber vegetables is parent only, tolerance-level residues were used for these commodities.

For the commodities in the current tolerance pe tition (mayhaw, summer squash, cucumber, and cabbage), residues of parent flu azinam as well as residues of AMGT were measured in the field trial studies. Similarly, for soybeans, cantaloupe , and peppers, residues of parent fluazinam as well as residues of AMGT were measured in the field trials (D. Dotson, D397722, 9/7/2012). For these commodities, the limit of quantificatio n (LOQ) for AMGT was 0.01 ppm. All samples had residue levels below the LOQ. As a result, the total residue used in the dietary exposure assessment was the tolerance plus 0.01 ppm.

Both fluazinam and AMGT were al so measured in the grape and apple field trials. The 3.0 ppm tolerance for grapes covers all residues of concer n. The fluazinam apple tolerance is 2.0 ppm, and the highest combined (fluazinam + AMGT) re sidue is below the tolerance (1.69 ppm). The apple tolerance was used in the acute asse ssment and the average combined (fluazinam + AMGT) residue value of 0.215 ppm was used in the chronic assessment. As part of the current tolerance petition, the tolerance on apple is being translated to mayhaw (for further details, see S.Fluazinam Dietary Exposure and Risk Assessme nt DP Number: D429506

Page 4 of 17 

### Biswas, D426161, 09/18/2015). As mayhaw is not in cluded in DEEM, this tolerance is not reflected in the residue input files or listed in Table 1.

For bushberries, the mean ratio of the metabolite:p arent residues (0.11:1) from field trials was used to estimate the total residues of con cern, and the bushberry to lerance of 7.0 ppm was multiplied by a factor of 1.11.

For the other commodities, an upper-bound ratio of 0.35:1 (AMGT:fluazinam) was used to estimate the AMGT residue. This factor is the maximum AMGT:fluazinam ratio in grapes determined in the grape metabolism study. The valu es obtained using this ratio were used in both the acute and chronic assessments. For more information concerning the residue levels used in the dietary exposure a ssessments, see the previous diet ary exposure memos that were written for fluazinam (D276982, W. Cutchin, 8/ 22/2001; D340854, M. Doherty, 8/1/2007; and D374522, D. Dotson, 3/31/2010).

In livestock commodities, the residues of concern for risk assessment and tolerance enforcement are the same: parent fluazinam, its meta bolites AMPA and DAPA, and their sulfamate conjugates. The tolerance leve l of 0.05 ppm is being used for meat byproducts and fat of cattle, goats, horses, and sheep (Memo, D360840, D. Do tson, 3/31/2010). This value is very conservative because it accounts for all residues of concern in the livestock commodities for which tolerances have been established.

DEEM 7.81 default processing factors were used for all processed commodities for which they were available (Table 2). Full listings of the re sidue inputs used in the analyses are included as Attachments 1 and 3.

Table 1. Summary of Crop Residue Levels Used in the Acute and Chronic Dietary Exposure Analyses Crop/Crop Group Tolerance Level (ppm) Residue Level used in Assessments (ppm) Derivation of Residue Level Carrots 0.70 0.70 Tolerance (parent only) Vegetable, Tuberous and Corm, Subgroup 1C 0.02 0.02 HED-Recommended Tolerance (parent only) Ginseng 4.5 4.5 Tolerance (parent only) Bulb Onions (Subgroup 3- 07A) 0.20 0.20 Tolerance (parent only)

Head Lettuce 0.02 0.027 0.02 tolerance x 1.35 Leaf Lettuce 2.0 2.7 2.0 tolerance x 1.35
Brassica Leafy Vegetables, except Cabbage 0.01 0.0135 0.01 tolerance x 1.35

Cabbage 3.0 3.01 HED-Recommended Tolerance + 0.01 Turnip Greens 0.01 0.0135 0.01 tolerance x 1.35 Edible-Podded Legumes, Subgroup 6-A, except pea 0.10 0.135 0.1 tolerance x 1.35

Succulent Shelled Legumes, Subgroup 6-B, except pea 0.04 0.054 0.04 tolerance x 1.35

Dried Shelled Legumes, Subgroup 6-C, except pea 0.02 0.027 0.02 tolerance x 1.35

Soybean 0.01 0.02 Tolerance + 0.01Fluazinam Dietary Exposure and Risk Assessme nt DP Number: D429506

Page 5 of 17 Peanuts 0.02 0.02 Tolerance (parent only) Peppers/Eggplant (8-10B) 0.09 0.10 Tolerance + 0.01 Cucurbit Vegetables, Group 9* 0.07 0.08 HED-Recommended Tolerance + 0.01 Apples (Acute Assessment) 2.0 2.0 Tolerance includes parent and AMGT Apples (Chronic Assessment) 2.0 0.215 Avg combined residue (fluazinam + AMGT) Bushberry Subgroup 13- 07B 7.0 7.8 Tolerance x 1.11

Wine Grapes (imported) 3.0 3.0 Tolerance includes parent and AMGT Fat of cattle, goat, horse, and sheep 0.05 0.05 Tolerance

Meat byproducts of cattle, goat, horse, and sheep 0.05 0.05 Tolerance

* Based on the available field trial data for summer squash and cucumber, it is appropriate to establish a cucurbit vegetable (Group 9) tolerance at 0.07 ppm (S. Biswas, D426161, 09/18/2015). This is an expansion from the existing subgroup 9A (Melon) tolerance at 0.07 ppm.

Table 2. Fluazinam Processing Factors. Commodity DEEM Default Processing Factors Apple Juice 1.3x Dried 8.0x Potato – dry 6.5x Onion – dried 9.0x Peanut - butter 1.89x Cranberry – juice 1.1x



### Residues in Fish

Tolerances have not been established for residues in fish commodities. Fluazinam has a low water solubility and a relatively high octanol/water pa rtition coefficient. As a result, it will not dissolve in water to a significant ex tent. Residues have the potential to partition into sediment at the bottoms of water bodies, however. Catfish are bottom feeders and residues in catfish serve as a marker for pesticide residues. The USDA Pe sticide Data Program (PDP) monitored pesticide residues in catfish in 2008, 2009, and 2010. The catfish samples were not analyzed for fluazinam, however. As a result, residues in fish were not included in the dietary exposure

assessments.

III. Percent Crop Treated Information

The acute and chronic assessments were bot h based on the assumption that 100% of all commodities with fluazinam tolerances will be treated.

IV. Drinking Water Data

The drinking water residues used in the di etary risk assessment were provided by the Environmental Fate and E ffects Division (EFED; D426144, J. Meléndez, 10/6/2015) and incorporated directly in to this dietary assessment into th e food categories “water, direct, allFluazinam Dietary Exposure and Risk Assessme nt DP Number: D429506

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### sources” and “water, indirect, all sources.” The residues of concern in drinking water for risk assessment are parent fluazinam and its tr ansformation products, including DCPA, CAPA, DAPA, HYPA, and AMPA.

The estimated acute and chronic EDWCs are based on ground application of fluazinam to turf. The values are provided in Table 3, below. The groundwater value was generated using the Pesticide Root Zone Model for Groundwater (PRZM-GW) Model and the surface water values were generated using the FQPA Index Reservoir Screening Tool (FIRST) Model. The surface water estimate was used for the acute assessmen t because this estimate was higher than the groundwater value. In contrast , the groundwater estimate was used for the chronic assessment, because this estimate was higher th an the surface water value. Both acute and chronic estimates included parent and degradates. For the acute assessment, a value of 226 ppb was used, and for the chronic assessment, a value of 119 ppb was us ed. This value also includes both parent and degradates. For more information a bout EFED’s drinking water models, see http://www.epa.gov/oppefed1/models/ water

.

Table 3. Maximum Tier 1 Estimated Drinki ng Water Concentrations Based on Ground Application of Fluazinam to Turf at a Seasonal Rate of 8.4 lb a.i./A

Source/Model Fluazinam Total Residues of Fluazinam 1 Acute/ppb Chronic/ppb Acute/ppb Chronic/ppb Surface Waters/FIRST 217 2 1.47 226 2 37.8 Groundwater/PRZM-GW 0.538 0.319 137 2 119 2

1. Including the following transformation pro ducts: DCPA, HYPA, CAPA, DAPA and AMPA.

2. Exceeds the solubility of fl uazinam at pH 7 (71 ppb), but not th e solubility at pH 11 (350 ppm).



### V. DEEM-FCID Program and Consumption Information

Fluazinam acute and chronic dietary exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database DEEM-FCID, Version 3.16, which incorporates 20 03-2008 consumption data from USDA’s NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 individuals over two non-consecu tive survey days. Foods “as consumed” (e.g., apple pie) are linked to EPA-defined food commoditi es (e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly avai lable recipe translation files developed jointly by USDA/ARS and EPA. For ch ronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups. However, for acute exposure assessment, consumption data are retain ed as individual consumption events. Based on analysis of the 2003-2008 WWEIA consumption da ta, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. popul ation, all infants (< 1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 years old.

For chronic dietary exposure assessment, an esti mate of the residue level in each food or foodform (e.g., orange or orange juice) on the f ood commodity residue list is multiplied by the average daily consumption estimate for that food/f ood form to produce a residue intake estimate. The resulting residue intake estimate for each f ood/food form is summed w ith the residue intakeFluazinam Dietary Exposure and Risk Assessme nt DP Number: D429506

Page 7 of 17 

### estimates for all other food/food forms on the comm odity residue list to arrive at the total average estimated exposure. Exposure is expres sed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup.

For acute exposure assessments, individual one-d ay food consumption data are used on an individual-by-individual basis. The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and a per-capita (i.e., those who reporte d eating the relevant commodities as well as those who did not) basi s. In accordance with HED policy, per capita exposure and risk are reported for assessments perf ormed at all levels of refinement. However, for unrefined assessments, any significant differences in user vs. per capita exposure and risk are specifically identified and not ed in the risk assessment.

VI. Toxicological Information

The toxicity data show that the primary target organ for chronic exposure to fluazinam is the liver. Liver effects in mice served as the ba sis for the chronic dietary endpoint. Acute neurotoxicity was seen in rats, and developmental toxicity was seen in rabbits. For acute dietary exposure assessment, different endpoints were selected for the General U.S. population and Females 13-49. The FQPA Safety Factor was re duced to 1x for all population subgroups. The CARC determined that quantification of risk using a non-linear approach (i.e., RfD) will adequately account for all chronic toxicity, including carcinogenicity, th at could result from exposure to fluazinam. The fluazinam doses and endpoints for use in dietary exposure assessments are summarized in Table 4.

Table 4. Toxicological Doses and Endpoints for Fluazinam for Use in Dietary and Non-Occupational Human Health Risk Assessments Exposure/ Scenario Point of Departure Uncertainty/ FQPA Safety Factors RfD, PAD, Level of Concern for Risk Assessment Study and Toxicological Effects

Acute Dietary (General population) NOAEL= 50 mg/kg/day UF A = 10x UF H =10x FQPA SF=1x Acute RfD =0.5 mg/kg/day

aPAD = 0.5mg/kg/day Acute Neurotoxicity-Rats LOAEL = 1000 mg/kg/day based on decreased motor activity and soft stools on day of dosing.

Acute Dietary (Females 13- 49 years of age) NOAEL (developmental) = 7 mg/kg/day UF A = 10x UF H =10x FQPA SF=1x Acute RfD =0.07 mg/kg/day

aPAD = 0.07mg/kg/day Developmental Toxicity- Rabbits Developmental LOAEL = 12 mg/kg/day based on increased incidence of total litter resorptions and possibly increased incidence of fetal skeletal abnormalities.Fluazinam Dietary Exposure and Risk Assessme nt DP Number: D429506

Page 8 of 17 Table 4. Toxicological Doses and Endpoints for Fluazinam for Use in Dietary and Non-Occupational Human Health Risk Assessments Exposure/ Scenario Point of Departure Uncertainty/ FQPA Safety Factors RfD, PAD, Level of Concern for Risk Assessment Study and Toxicological Effects

Chronic Dietary (All Populations) NOAEL= 1.1 mg/kg/day UF A = 10x UF H =10x FQPA SF=1x Chronic RfD =0.011 mg/kg/day

cPAD = 0.011mg/kg/day Carcinogenicity-Mice LOAEL = 10.7 mg/kg/day based on liver histopathology and increased liver weight.

Cancer (oral, dermal, inhalation) Classification: “Suggestive Evidence of Carcinog enicity, but not sufficient to assess human carcinogenic potential.”

NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A = extrapolation from animal to human (interspecies). UF H = potential variation in sensitivity among members of the human population (intraspecies). FQPA SF = FQPA Sa fety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD = reference dose.



### VII. Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM-FCID analyses estimate the dietary exposure of the U.S. population and various population subgroups. The resu lts reported in Table 5 are for the general U.S. population, all infants (<1 year old), child ren 1-2, children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50-99 years. Risk estimates are below HED’s level of concern for all population subgroups in bot h the acute and chronic analyses.

The acute risk estimate for the General U.S. Population is 5.7% of the aPAD. The aPAD is lower for females 13 to 49 years old. Although Ch ildren 1-2 years old have the highest exposure estimate (0.112064 mg/kg/day; 22% aPAD), the population subgroup with the highest risk estimate is females 13 to 49 years old, which utilizes 32% of the aP AD (0.022220 mg/kg/day).

The chronic risk estimate for the general U.S. population is 41% of the cPAD. The most highly exposed population subgroup is All Infants, wh ich uses 92% of the cPAD. Finally, cancer dietary risk assessment was not required.

Full listings of exposure and risk estimates are included in Attachments 2 (acute analysis) and 4 (chronic analysis).

Table 5. Summary of Acute and Chronic Exposure and Risk Estimates for Fluazinam

Population Subgroup Acute Assessment (95 th Percentile) Chronic Assessment

aPAD, mg/kg/day Exposure Estimate, mg/kg/day % aPAD cPAD, mg/kg/day Exposure Estimate, mg/kg/day % cPAD

U.S Population 0.5 0.028533 5.7 0.011 0.004521 41
All infants* 0.5 0.085186 17 0.011 0.010122 92 Children 1-2 yrs 0.5 0.112064 22 0.011 0.009750 89 Children 3-5 yrs 0.5 0.065310 13 0.011 0.006614 60 Children 6-12 yrs 0.5 0.034218 6.8 0.011 0.004161 38Fluazinam Dietary Exposure and Risk Assessme nt DP Number: D429506

Page 9 of 17 Table 5. Summary of Acute and Chronic Exposure and Risk Estimates for Fluazinam

Population Subgroup Acute Assessment (95 th Percentile) Chronic Assessment

aPAD, mg/kg/day Exposure Estimate, mg/kg/day % aPAD cPAD, mg/kg/day Exposure Estimate, mg/kg/day % cPAD

Youth 13-19 yrs 0.5 0.019517 3.9 0.011 0.002981 27 Adults 20-49 yrs 0.5 0.021791 4.4 0.011 0.004243 39 Adults 50-99 yrs 0.5 0.019444 3.9 0.011 0.004490 41 Females 13-49 yrs* 0.07 0.022220 32 0.011 0.004338 39 *The subpopulation with the highest acute or chronic risk estimate



### VIII. Characterization of Inputs/Outputs

HED considers both the acute and chronic assessments to be ve ry conservative. The acute assessment is based on tolerance-level residues fo r all commodities, with worst-case assumptions being made for residue levels of the metabolite AMGT. In addition, it was assumed that 100% of all crops with registered or requested uses of fluazinam will be treated. The EDWCs include parent fluazinam and its transformation produc ts. The acute assessment assumed that the degradates were as toxic as pare nt fluazinam. These same assumptions and inputs were used for the chronic assessment, except that an average field trial value was used for apples. These assumptions result in highly conservative, health -protective estimates of exposure and risk. In the event that refinements need to be made in the future, percent crop treated estimates, average field trial values, and monitoring data can be incorporated into the assessments.

IX. Conclusions

The exposure estimates generated by the dietary exposure model that was used are conservative estimates of dietary exposure. Even so, the acute and chronic aggregate (food + drinking water) dietary risk estimates for the general U.S. population and all populati on subgroups are not of

concern. The chronic dietary exposure assessment is prot ective for cancer. Ca ncer risk is also not of concern.

X. List of Attachments

Attachment 1. Acute Dietary Re sidue Input File for Fluazinam Attachment 2. Results of Acute Dietary Exposure Assessment Attachment 3. Chronic Dietary Re sidue Input File for Fluazinam Attachment 4. Results of Chronic Dietary Exposure AssessmentFluazinam Dietary Exposure and Risk Assessme nt DP Number: D429506

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### Attachment 1: Acute Dietary Re sidue Input File for Fluazinam

DEEM FCID Version 3.16

Acute NOAEL for general population including infants and children: 50 mg/kg bw/day Acute PAD for general population including infants and children: 0.5 mg/kg bw/day

Acute NOAEL for Females 13-49: 7 mg/kg bw/day Acute PAD for Females 13-49: 0.07 mg/kg bw/day

Filename: F:\Fluazinam\Fluazinam2012acute_111615.R08 Chemical: Fluazinam RfD(Chronic): .011 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): .5 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Date created/last modified: 11-16-2015/15:04:23 Program ver. 3.16, 03-08-d Comment: aPAD of 0.5 kg/day is for general pop. Female 13-49 aPAD = 0.07 mg/day

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0101078000 1AB Carrot 0.700000 1.000 1.000 0101078001 1AB Carrot-babyfood 0.700000 1.000 1.000 0101079000 1AB Carrot, juice 0.700000 1.000 1.000 0101168000 1AB Ginseng, dried 4.500000 1.000 1.000 0103015000 1CD Arrowroot, flour 0.020000 1.000 1.000 0103015001 1CD Arrowroot, flour-babyfood 0.020000 1.000 1.000 0103017000 1CD Artichoke, Jerusalem 0.020000 1.000 1.000 0103082000 1CD Cassava 0.020000 1.000 1.000 0103082001 1CD Cassava-babyfood 0.020000 1.000 1.000 0103139000 1CD Dasheen, corm 0.020000 1.000 1.000 0103166000 1CD Ginger 0.020000 1.000 1.000 0103166001 1CD Ginger-babyfood 0.020000 1.000 1.000 0103167000 1CD Ginger, dried 0.020000 1.000 1.000 0103296000 1C Potato, chips 0.020000 1.000 1.000 0103297000 1C Potato, dry (granules/ flakes) 0.020000 6.500 1.000 0103297001 1C Potato, dry (granules/ flakes)-b 0.020000 6.500 1.000 0103298000 1C Potato, flour 0.020000 6.500 1.000 0103298001 1C Potato, flour-babyfood 0.020000 6.500 1.000 0103299000 1C Potato, tuber, w/peel 0.020000 1.000 1.000 0103299001 1C Potato, tuber, w/peel-babyfood 0.020000 1.000 1.000 0103300000 1C Potato, tuber, w/o peel 0.020000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel-babyfood 0.020000 1.000 1.000 0103366000 1CD Sweet potato 0.020000 1.000 1.000 0103366001 1CD Sweet potato-babyfood 0.020000 1.000 1.000 0103371000 1CD Tanier, corm 0.020000 1.000 1.000 0103387000 1CD Turmeric 0.020000 1.000 1.000 0103406000 1CD Yam, true 0.020000 1.000 1.000 0103407000 1CD Yam bean 0.020000 1.000 1.000 0301165000 3A Garlic, bulb 0.200000 1.000 1.000 0301165001 3A Garlic, bulb-babyfood 0.200000 1.000 1.000 0301237000 3A Onion, bulb 0.200000 1.000 1.000 0301237001 3A Onion, bulb-babyfood 0.200000 1.000 1.000 0301238000 3A Onion, bulb, dried 0.200000 9.000 1.000 0301238001 3A Onion, bulb, dried-babyfood 0.200000 9.000 1.000 0301338000 3A Shallot, bulb 0.200000 1.000 1.000 0401204000 4A Lettuce, head 0.027000 1.000 1.000 0401205000 4A Lettuce, leaf 2.700000 1.000 1.000 0501061000 5A Broccoli 0.013500 1.000 1.000 0501061001 5A Broccoli-babyfood 0.013500 1.000 1.000 0501062000 5A Broccoli, Chinese 0.013500 1.000 1.000 0501064000 5A Brussels sprouts 0.013500 1.000 1.000 0501069000 5A Cabbage 3.010000 1.000 1.000 0501071000 5A Cabbage, Chinese, napa 3.010000 1.000 1.000Fluazinam Dietary Exposure and Risk Assessme nt DP Number: D429506

Page 11 of 17 0501072000 5A Cabbage, Chinese, mustard 0.013500 1.000 1.000 0501083000 5A Cauliflower 0.013500 1.000 1.000 0501196000 5A Kohlrabi 0.013500 1.000 1.000 0502063000 5B Broccoli raab 0.013500 1.000 1.000 0502070000 5B Cabbage, Chinese, bok choy 0.013500 1.000 1.000 0502117000 5B Collards 0.013500 1.000 1.000 0502194000 5B Kale 0.013500 1.000 1.000 0502229000 5B Mustard greens 0.013500 1.000 1.000 0502318000 5B Rape greens 0.013500 1.000 1.000 0502389000 5B Turnip, greens 0.013500 1.000 1.000 0600347000 6 Soybean, seed 0.020000 1.000 1.000 0600349000 6 Soybean, soy milk 0.020000 1.000 1.000 0600349001 6 Soybean, soy milk-babyfood or in 0.020000 1.000 1.000 0600350000 6 Soybean, oil 0.020000 1.000 1.000 0600350001 6 Soybean, oil-babyfood 0.020000 1.000 1.000 0601043000 6A Bean, snap, succulent 0.135000 1.000 1.000 0601043001 6A Bean, snap, succulent-babyfood 0.135000 1.000 1.000 0601349500 6AB Soybean, vegetable 0.135000 1.000 1.000 0602031000 6B Bean, broad, succulent 0.054000 1.000 1.000 0602033000 6B Bean, cowpea, succulent 0.054000 1.000 1.000 0602037000 6B Bean, lima, succulent 0.054000 1.000 1.000 0603030000 6C Bean, black, seed 0.027000 1.000 1.000 0603032000 6C Bean, broad, seed 0.027000 1.000 1.000 0603034000 6C Bean, cowpea, seed 0.027000 1.000 1.000 0603035000 6C Bean, great northern, seed 0.027000 1.000 1.000 0603036000 6C Bean, kidney, seed 0.027000 1.000 1.000 0603038000 6C Bean, lima, seed 0.027000 1.000 1.000 0603039000 6C Bean, mung, seed 0.027000 1.000 1.000 0603040000 6C Bean, navy, seed 0.027000 1.000 1.000 0603041000 6C Bean, pink, seed 0.027000 1.000 1.000 0603042000 6C Bean, pinto, seed 0.027000 1.000 1.000 0603098000 6C Chickpea, seed 0.027000 1.000 1.000 0603098001 6C Chickpea, seed-babyfood 0.027000 1.000 1.000 0603099000 6C Chickpea, flour 0.027000 1.000 1.000 0603182000 6C Guar, seed 0.027000 1.000 1.000 0603182001 6C Guar, seed-babyfood 0.027000 1.000 1.000 0603348000 6C Soybean, flour 0.020000 1.000 1.000 0603348001 6C Soybean, flour-babyfood 0.020000 1.000 1.000 0802148000 8BC Eggplant 0.100000 1.000 1.000 0802234000 8BC Okra 0.100000 1.000 1.000 0802270000 8B Pepper, bell 0.100000 1.000 1.000 0802270001 8B Pepper, bell-babyfood 0.100000 1.000 1.000 0802271000 8B Pepper, bell, dried 0.100000 1.000 1.000 0802271001 8B Pepper, bell, dried-babyfood 0.100000 1.000 1.000 0802272000 8BC Pepper, nonbell 0.100000 1.000 1.000 0802272001 8BC Pepper, nonbell-babyfood 0.100000 1.000 1.000 0802273000 8BC Pepper, nonbell, dried 0.100000 1.000 1.000 0901075000 9A Cantaloupe 0.080000 1.000 1.000 0901187000 9A Honeydew melon 0.080000 1.000 1.000 0901399000 9A Watermelon 0.080000 1.000 1.000 0901400000 9A Watermelon, juice 0.080000 1.000 1.000 0902021000 9B Balsam pear 0.080000 1.000 1.000 0902088000 9B Chayote, fruit 0.080000 1.000 1.000 0902102000 9B Chinese waxgourd 0.080000 1.000 1.000 0902135000 9B Cucumber 0.080000 1.000 1.000 0902308000 9B Pumpkin 0.080000 1.000 1.000 0902309000 9B Pumpkin, seed 0.080000 1.000 1.000 0902356000 9B Squash, summer 0.080000 1.000 1.000 0902356001 9B Squash, summer-babyfood 0.080000 1.000 1.000 0902357000 9B Squash, winter 0.080000 1.000 1.000 0902357001 9B Squash, winter-babyfood 0.080000 1.000 1.000 1100007000 11 Apple, fruit with peel 2.000000 1.000 1.000 1100008000 11 Apple, peeled fruit 2.000000 1.000 1.000 1100008001 11 Apple, peeled fruit-babyfood 2.000000 1.000 1.000 1100009000 11 Apple, dried 2.000000 8.000 1.000 1100009001 11 Apple, dried-babyfood 2.000000 8.000 1.000 1100010000 11 Apple, juice 2.000000 1.300 1.000Fluazinam Dietary Exposure and Risk Assessme nt DP Number: D429506

Page 12 of 17 1100010001 11 Apple, juice-babyfood 2.000000 1.300 1.000 1100011000 11 Apple, sauce 2.000000 1.000 1.000 1100011001 11 Apple, sauce-babyfood 2.000000 1.000 1.000 1302057000 13B Blueberry 7.800000 1.000 1.000 1302057001 13B Blueberry-babyfood 7.800000 1.000 1.000 1302136000 13B Currant 7.800000 1.000 1.000 1302137000 13B Currant, dried 7.800000 1.000 1.000 1302149000 13B Elderberry 7.800000 1.000 1.000 1302174000 13B Gooseberry 7.800000 1.000 1.000 1302191000 13B Huckleberry 7.800000 1.000 1.000 1304179000 13D Grape, wine and sherry 3.000000 1.000 1.000 1307130000 13G Cranberry 7.800000 1.000 1.000 1307130001 13G Cranberry-babyfood 7.800000 1.000 1.000 1307131000 13G Cranberry, dried 7.800000 1.000 1.000 1307132000 13G Cranberry, juice 7.800000 1.100 1.000 1307132001 13G Cranberry, juice-babyfood 7.800000 1.100 1.000 3100046000 31 Beef, meat byproducts 0.050000 1.000 1.000 3100046001 31 Beef, meat byproducts-babyfood 0.050000 1.000 1.000 3100047000 31 Beef, fat 0.050000 1.000 1.000 3100047001 31 Beef, fat-babyfood 0.050000 1.000 1.000 3100048000 31 Beef, kidney 0.050000 1.000 1.000 3100049000 31 Beef, liver 0.050000 1.000 1.000 3100049001 31 Beef, liver-babyfood 0.050000 1.000 1.000 3200170000 32 Goat, meat byproducts 0.050000 1.000 1.000 3200171000 32 Goat, fat 0.050000 1.000 1.000 3200172000 32 Goat, kidney 0.050000 1.000 1.000 3200173000 32 Goat, liver 0.050000 1.000 1.000 3500340000 35 Sheep, meat byproducts 0.050000 1.000 1.000 3500341000 35 Sheep, fat 0.050000 1.000 1.000 3500341001 35 Sheep, fat-babyfood 0.050000 1.000 1.000 3500342000 35 Sheep, kidney 0.050000 1.000 1.000 3500343000 35 Sheep, liver 0.050000 1.000 1.000 8601000000 86A Water, direct, all sources 0.226000 1.000 1.000 8602000000 86B Water, indirect, all sources 0.226000 1.000 1.000 9500263000 O Peanut 0.020000 1.000 1.000 9500264000 O Peanut, butter 0.020000 1.890 1.000 9500265000 O Peanut, oil 0.020000 1.000 1.000Fluazinam Dietary Exposure and Risk Assessme nt DP Number: D429506

Page 13 of 17 

### Attachment 2: Results of Ac ute Dietary Exposure Assessment

US EPA Ver. 3.18, 03-08-d DEEM-FCID ACUTE Analysis for FLUAZINAM NHANES 2003-2008 2-Day Residue file: Fluazinam2012acute_111615.R08 Adjustment factor #2 NOT used. Analysis Date: 11-16-2015/16:28:19 Residue file dated: 11-16-2015/15:04:23 Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports RAC/FF intake summed over 24 hours Run Comment: "aPAD of 0.5 kg/day is for general pop. Female 13-49 aPAD = 0.07 mg/day"

===============================================================================

Summary calculations--per capita:

95th Percentile 99th Percentile 99.9th Percentile Exposure % aPAD Exposure % aPAD Exposure % aPAD

---------- -------- ---------- -------- ---------- -------- Total US Population: 0.028533 5.71 0.065050 13.01 0.158547 31.71 All Infants: 0.085186 17.04 0.154200 30.84 0.287216 57.44 Children 1-2: 0.112064 22.41 0.192396 38.48 0.310428 62.09 Children 3-5: 0.065310 13.06 0.120591 24.12 0.204321 40.86 Children 6-12: 0.034218 6.84 0.068100 13.62 0.122136 24.43 Youth 13-19: 0.019517 3.90 0.036854 7.37 0.059213 11.84 Adults 20-49: 0.021791 4.36 0.035015 7.00 0.073850 14.77 Adults 50-99: 0.019444 3.89 0.031316 6.26 0.051628 10.33 Female 13-49: 0.022220 31.74 0.036769 52.53 0.079600 113.71Fluazinam Dietary Exposure and Risk Assessme nt DP Number: D429506

Page 14 of 17 

### Attachment 3: Chronic Dietary Residue Input File for Fluazinam

DEEM FCID Version 3.16

Chronic NOAEL: 1.1 mg/kg bw/day Chronic PAD: 0.011 mg/kg bw/day

Filename: F:\Fluazinam\Fluazinam2015chronic_111615.R08 Chemical: Fluazinam RfD(Chronic): .011 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): .5 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Date created/last modified: 11-16-2015/15:05:13 Program ver. 3.16, 03-08-d Comment: aPAD of 0.5 kg/day is for general pop. Female 13-49 aPAD = 0.07 mg/day

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0101078000 1AB Carrot 0.700000 1.000 1.000 0101078001 1AB Carrot-babyfood 0.700000 1.000 1.000 0101079000 1AB Carrot, juice 0.700000 1.000 1.000 0101168000 1AB Ginseng, dried 4.500000 1.000 1.000 0103015000 1CD Arrowroot, flour 0.020000 1.000 1.000 0103015001 1CD Arrowroot, flour-babyfood 0.020000 1.000 1.000 0103017000 1CD Artichoke, Jerusalem 0.020000 1.000 1.000 0103082000 1CD Cassava 0.020000 1.000 1.000 0103082001 1CD Cassava-babyfood 0.020000 1.000 1.000 0103139000 1CD Dasheen, corm 0.020000 1.000 1.000 0103166000 1CD Ginger 0.020000 1.000 1.000 0103166001 1CD Ginger-babyfood 0.020000 1.000 1.000 0103167000 1CD Ginger, dried 0.020000 1.000 1.000 0103296000 1C Potato, chips 0.020000 1.000 1.000 0103297000 1C Potato, dry (granules/ flakes) 0.020000 6.500 1.000 0103297001 1C Potato, dry (granules/ flakes)-b 0.020000 6.500 1.000 0103298000 1C Potato, flour 0.020000 6.500 1.000 0103298001 1C Potato, flour-babyfood 0.020000 6.500 1.000 0103299000 1C Potato, tuber, w/peel 0.020000 1.000 1.000 0103299001 1C Potato, tuber, w/peel-babyfood 0.020000 1.000 1.000 0103300000 1C Potato, tuber, w/o peel 0.020000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel-babyfood 0.020000 1.000 1.000 0103366000 1CD Sweet potato 0.020000 1.000 1.000 0103366001 1CD Sweet potato-babyfood 0.020000 1.000 1.000 0103371000 1CD Tanier, corm 0.020000 1.000 1.000 0103387000 1CD Turmeric 0.020000 1.000 1.000 0103406000 1CD Yam, true 0.020000 1.000 1.000 0103407000 1CD Yam bean 0.020000 1.000 1.000 0301165000 3A Garlic, bulb 0.200000 1.000 1.000 0301165001 3A Garlic, bulb-babyfood 0.200000 1.000 1.000 0301237000 3A Onion, bulb 0.200000 1.000 1.000 0301237001 3A Onion, bulb-babyfood 0.200000 1.000 1.000 0301238000 3A Onion, bulb, dried 0.200000 9.000 1.000 0301238001 3A Onion, bulb, dried-babyfood 0.200000 9.000 1.000 0301338000 3A Shallot, bulb 0.200000 1.000 1.000 0401204000 4A Lettuce, head 0.027000 1.000 1.000 0401205000 4A Lettuce, leaf 2.700000 1.000 1.000 0501061000 5A Broccoli 0.013500 1.000 1.000 0501061001 5A Broccoli-babyfood 0.013500 1.000 1.000 0501062000 5A Broccoli, Chinese 0.013500 1.000 1.000 0501064000 5A Brussels sprouts 0.013500 1.000 1.000 0501069000 5A Cabbage 3.010000 1.000 1.000 0501071000 5A Cabbage, Chinese, napa 3.010000 1.000 1.000 0501072000 5A Cabbage, Chinese, mustard 0.013500 1.000 1.000 0501083000 5A Cauliflower 0.013500 1.000 1.000 0501196000 5A Kohlrabi 0.013500 1.000 1.000 0502063000 5B Broccoli raab 0.013500 1.000 1.000 0502070000 5B Cabbage, Chinese, bok choy 0.013500 1.000 1.000Fluazinam Dietary Exposure and Risk Assessme nt DP Number: D429506

Page 15 of 17 0502117000 5B Collards 0.013500 1.000 1.000 0502194000 5B Kale 0.013500 1.000 1.000 0502229000 5B Mustard greens 0.013500 1.000 1.000 0502318000 5B Rape greens 0.013500 1.000 1.000 0502389000 5B Turnip, greens 0.013500 1.000 1.000 0600347000 6 Soybean, seed 0.020000 1.000 1.000 0600349000 6 Soybean, soy milk 0.020000 1.000 1.000 0600349001 6 Soybean, soy milk-babyfood or in 0.020000 1.000 1.000 0600350000 6 Soybean, oil 0.020000 1.000 1.000 0600350001 6 Soybean, oil-babyfood 0.020000 1.000 1.000 0601043000 6A Bean, snap, succulent 0.135000 1.000 1.000 0601043001 6A Bean, snap, succulent-babyfood 0.135000 1.000 1.000 0601349500 6AB Soybean, vegetable 0.135000 1.000 1.000 0602031000 6B Bean, broad, succulent 0.054000 1.000 1.000 0602033000 6B Bean, cowpea, succulent 0.054000 1.000 1.000 0602037000 6B Bean, lima, succulent 0.054000 1.000 1.000 0603030000 6C Bean, black, seed 0.027000 1.000 1.000 0603032000 6C Bean, broad, seed 0.027000 1.000 1.000 0603034000 6C Bean, cowpea, seed 0.027000 1.000 1.000 0603035000 6C Bean, great northern, seed 0.027000 1.000 1.000 0603036000 6C Bean, kidney, seed 0.027000 1.000 1.000 0603038000 6C Bean, lima, seed 0.027000 1.000 1.000 0603039000 6C Bean, mung, seed 0.027000 1.000 1.000 0603040000 6C Bean, navy, seed 0.027000 1.000 1.000 0603041000 6C Bean, pink, seed 0.027000 1.000 1.000 0603042000 6C Bean, pinto, seed 0.027000 1.000 1.000 0603098000 6C Chickpea, seed 0.027000 1.000 1.000 0603098001 6C Chickpea, seed-babyfood 0.027000 1.000 1.000 0603099000 6C Chickpea, flour 0.027000 1.000 1.000 0603182000 6C Guar, seed 0.027000 1.000 1.000 0603182001 6C Guar, seed-babyfood 0.027000 1.000 1.000 0603348000 6C Soybean, flour 0.020000 1.000 1.000 0603348001 6C Soybean, flour-babyfood 0.020000 1.000 1.000 0802148000 8BC Eggplant 0.100000 1.000 1.000 0802234000 8BC Okra 0.100000 1.000 1.000 0802270000 8B Pepper, bell 0.100000 1.000 1.000 0802270001 8B Pepper, bell-babyfood 0.100000 1.000 1.000 0802271000 8B Pepper, bell, dried 0.100000 1.000 1.000 0802271001 8B Pepper, bell, dried-babyfood 0.100000 1.000 1.000 0802272000 8BC Pepper, nonbell 0.100000 1.000 1.000 0802272001 8BC Pepper, nonbell-babyfood 0.100000 1.000 1.000 0802273000 8BC Pepper, nonbell, dried 0.100000 1.000 1.000 0901075000 9A Cantaloupe 0.080000 1.000 1.000 0901187000 9A Honeydew melon 0.080000 1.000 1.000 0901399000 9A Watermelon 0.080000 1.000 1.000 0901400000 9A Watermelon, juice 0.080000 1.000 1.000 0902021000 9B Balsam pear 0.080000 1.000 1.000 0902088000 9B Chayote, fruit 0.080000 1.000 1.000 0902102000 9B Chinese waxgourd 0.080000 1.000 1.000 0902135000 9B Cucumber 0.080000 1.000 1.000 0902308000 9B Pumpkin 0.080000 1.000 1.000 0902309000 9B Pumpkin, seed 0.080000 1.000 1.000 0902356000 9B Squash, summer 0.080000 1.000 1.000 0902356001 9B Squash, summer-babyfood 0.080000 1.000 1.000 0902357000 9B Squash, winter 0.080000 1.000 1.000 0902357001 9B Squash, winter-babyfood 0.080000 1.000 1.000 1100007000 11 Apple, fruit with peel 0.215000 1.000 1.000 1100008000 11 Apple, peeled fruit 0.215000 1.000 1.000 1100008001 11 Apple, peeled fruit-babyfood 0.215000 1.000 1.000 1100009000 11 Apple, dried 0.215000 8.000 1.000 1100009001 11 Apple, dried-babyfood 0.215000 8.000 1.000 1100010000 11 Apple, juice 0.215000 1.300 1.000 1100010001 11 Apple, juice-babyfood 0.215000 1.300 1.000 1100011000 11 Apple, sauce 0.215000 1.000 1.000 1100011001 11 Apple, sauce-babyfood 0.215000 1.000 1.000 1302057000 13B Blueberry 7.800000 1.000 1.000 1302057001 13B Blueberry-babyfood 7.800000 1.000 1.000Fluazinam Dietary Exposure and Risk Assessme nt DP Number: D429506

Page 16 of 17 1302136000 13B Currant 7.800000 1.000 1.000 1302137000 13B Currant, dried 7.800000 1.000 1.000 1302149000 13B Elderberry 7.800000 1.000 1.000 1302174000 13B Gooseberry 7.800000 1.000 1.000 1302191000 13B Huckleberry 7.800000 1.000 1.000 1304179000 13D Grape, wine and sherry 3.000000 1.000 1.000 1307130000 13G Cranberry 7.800000 1.000 1.000 1307130001 13G Cranberry-babyfood 7.800000 1.000 1.000 1307131000 13G Cranberry, dried 7.800000 1.000 1.000 1307132000 13G Cranberry, juice 7.800000 1.100 1.000 1307132001 13G Cranberry, juice-babyfood 7.800000 1.100 1.000 3100046000 31 Beef, meat byproducts 0.050000 1.000 1.000 3100046001 31 Beef, meat byproducts-babyfood 0.050000 1.000 1.000 3100047000 31 Beef, fat 0.050000 1.000 1.000 3100047001 31 Beef, fat-babyfood 0.050000 1.000 1.000 3100048000 31 Beef, kidney 0.050000 1.000 1.000 3100049000 31 Beef, liver 0.050000 1.000 1.000 3100049001 31 Beef, liver-babyfood 0.050000 1.000 1.000 3200170000 32 Goat, meat byproducts 0.050000 1.000 1.000 3200171000 32 Goat, fat 0.050000 1.000 1.000 3200172000 32 Goat, kidney 0.050000 1.000 1.000 3200173000 32 Goat, liver 0.050000 1.000 1.000 3500340000 35 Sheep, meat byproducts 0.050000 1.000 1.000 3500341000 35 Sheep, fat 0.050000 1.000 1.000 3500341001 35 Sheep, fat-babyfood 0.050000 1.000 1.000 3500342000 35 Sheep, kidney 0.050000 1.000 1.000 3500343000 35 Sheep, liver 0.050000 1.000 1.000 8601000000 86A Water, direct, all sources 0.119000 1.000 1.000 8602000000 86B Water, indirect, all sources 0.119000 1.000 1.000 9500263000 O Peanut 0.020000 1.000 1.000 9500264000 O Peanut, butter 0.020000 1.890 1.000 9500265000 O Peanut, oil 0.020000 1.000 1.000Fluazinam Dietary Exposure and Risk Assessme nt DP Number: D429506

Page 17 of 17 

### Attachment 4: Results of Ch ronic Dietary Exposure Assessment

US EPA Ver. 3.16, 03-08-d DEEM-FCID Chronic analysis for FLUAZINAM NHANES 2003-2008 2-day Residue file name: F:\Fluazinam\Fluazinam2015chronic_111615.R08 Adjustment factor #2 NOT used. Analysis Date 11-16-2015/15:31:43 Residue file dated: 11-16-2015/15:05:13 Reference dose (RfD, Chronic) = .011 mg/kg bw/day COMMENT 1: aPAD of 0.5 kg/day is for general pop. Female 13-49 aPAD = 0.07 mg/day

=============================================================================== Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- ---------------- Total US Population 0.004521 41.1% Hispanic 0.004005 36.4% Non-Hisp-White 0.004701 42.7% Non-Hisp-Black 0.003868 35.2% Non-Hisp-Other 0.005004 45.5% Nursing Infants 0.004234 38.5% Non-Nursing Infants 0.012751 115.9% Female 13+ PREG 0.003598 32.7% Children 1-6 0.007538 68.5% Children 7-12 0.003927 35.7% Male 13-19 0.002809 25.5% Female 13-19/NP 0.003155 28.7% Male 20+ 0.003928 35.7% Female 20+/NP 0.004752 43.2% Seniors 55+ 0.004539 41.3% All Infants 0.010122 92.0% Female 13-50 0.004346 39.5% Children 1-2 0.009750 88.6% Children 3-5 0.006614 60.1% Children 6-12 0.004161 37.8% Youth 13-19 0.002981 27.1% Adults 20-49 0.004243 38.6% Adults 50-99 0.004490 40.8% Female 13-49 0.004338 39.4%

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