2 

Huntsman Corporation on behalf of the Joint Inerts Task Force, Cluster Support Team 8 

(JITF CST 8) submitted a petition (2E8087) requesting to amend two exemptions from 

the requirement of a tolerance for dimethylaminopropylamine, isopropylamine, 

ethanolamine, and triethanolamine salts of alkyl (C8-C24) benzenesulfonic acid (without 

limitation) and diethanolamine salts of alkyl (C8-C24) benzenesulfonic acid (not to exceed 

7% in pesticidal formulations) under 40 CFR 180.920 and 180.930. This request is to 

amend the existing tolerance exemptions to include additional CAS Reg. Nos. (See Table 

1 and Table 2). A Notice of Filing for this petition was published in the Federal Register 

on June 5, 2013 (78 FR 33785). There were no comments received in response to this 

notice. 

The purpose of this document is to assess, as required under the Federal Food Drug and 

Cosmetic Act (FFDCA), the risk of the use of the additional CAS Reg. Nos. as inert 

ingredients in pesticide products and is based on a previous assessment for the subject 

chemicals along with a rationale provided by the petitioner as to why the additional CAS 

Reg. Nos. can be considered safe under the existing tolerance exemption descriptors for 

dimethylaminopropylamine, isopropylamine, ethanolamine, and triethanolamine salts of 

alkyl (C8-C24) benzenesulfonic acid and diethanolamine salts of alkyl (C8-C24) 

benzenesulfonic acid; under 40 CFR 180.920 & 180.930. 

A previous assessment was completed on July 23, 2009 and a final rule establishing 

exemptions from the requirement of a tolerance for residues of 

dimethylaminopropylamine, isopropylamine, ethanolamine, and triethanolamine salts of 

alkyl (C8-C24) benzenesulfonic acid and diethanolamine salts of alkyl (C8-C24) 

benzenesulfonic acid under 40 CFR 180.920 and 180.930 was published on August 5, 

2009 (74 FR 38924). 

These exemptions were established based on information submitted by the JITF CST 8. 

Specific information on the studies received from the JITF CST 8 to support the request 

to establish exemptions from the requirement a tolerance and the nature of the adverse 

effects caused by dimethylaminopropylamine, isopropylamine, ethanolamine, and 

triethanolamine salts of alkyl (C8-C24) benzenesulfonic acid and diethanolamine salts of 

alkyl (C8-C24) benzenesulfonic acid as well as the no- observed-adverse-effect-level 

(NOAEL) and the lowest-observed-adverse-effect-level (LOAEL) from the toxicity 

studies can be found at http:// www.regulations.gov in documents 

“Dimethylaminopropylamine, Isopropylamine, Ethanolamine, and Triethanolamine Salts 

of Alkyl (C8-C24) Benzenesulfonic acid (JITF CST 8 Inert Ingredients). Human Health 

Risk Assessment to Support Proposed Exemption from the Requirement of a Tolerance 

When Used as Inert Ingredient in Pesticide Formulations.” and “Diethanolamine Salts of 

Alkyl (C8-C24) Benzenesulfonic Acid (DEA – JITF CST 8 Inert Ingredient). Human 

Health Risk Assessment to Support Proposed Exemption from the Requirement of a 

Tolerance When Used as Inert Ingredient in Pesticide Formulations.” in docket ID 

number EPA-HQ-OPP-2008-0889. 
3 

The Agency has reviewed the JITF CST 8’s claim that the addition of the requested CAS 

Reg. Nos. is acceptable under the current tolerance exemption descriptors for 

dimethylaminopropylamine, isopropylamine, ethanolamine, and triethanolamine salts of 

alkyl (C8-C24) benzenesulfonic acid and diethanolamine salts of alkyl (C8-C24) 

benzenesulfonic acid. IIAB has confirmed that the requested CAS Reg. Nos. are 

appropriately added to the currently approved descriptors and that no further review is 

required. The requested CAS Registry Numbers all describe compounds that are either 

dimethylaminopropylamine, isopropylamine, ethanolamine, and triethanolamine salts of 

alkyl (C8-C24) benzenesulfonic acid or diethanolamine salts of alkyl (C8-C24) 

benzenesulfonic acid and, as such, fall within the existing tolerance exemption 

descriptors in 40 CFR 180.920 and 40 CFR 180.930. 

The Agency has determined that the proposed addition of the requested CAS Reg. Nos. is 

adequately supported by the existing data and assessment and that no additional data or 

review is required. Inclusion of the additional chemicals described above in the risk 

assessments for the dimethylaminopropylamine, isopropylamine, ethanolamine, and 

triethanolamine salts of alkyl (C8-C24) benzenesulfonic acid and diethanolamine salts of 

alkyl (C8-C24) benzenesulfonic acid would in no way alter the prior risk assessment given 

the generic findings on toxicity and the worst case exposure assumptions used in the risk 

assessment. Accordingly, based on the findings in that earlier rule, EPA has determined 

that there is a reasonable certainty that no harm to any population subgroup, including 

infants and children, will result from aggregate exposure to dimethylaminopropylamine, 

isopropylamine, ethanolamine, and triethanolamine salts of alkyl (C8-C24) 

benzenesulfonic acid and diethanolamine salts of alkyl (C8-C24) benzenesulfonic acid by 

including the additional chemicals described in Tables 1 and 2, under reasonably 

foreseeable circumstances. 

Therefore, the amendment of an exemption from tolerance under 40 CFR 180.920 and 

180.930 for residues of dimethylaminopropylamine, isopropylamine, ethanolamine, and 

triethanolamine salts of alkyl (C8-C24) benzenesulfonic acid and diethanolamine salts of 

alkyl (C8-C24) benzenesulfonic acid (not to exceed 7% of pesticidal formulations) to 

include the requested CAS Reg. Nos. (See Table 1 and Table 2) when used as inert 

ingredients (surfactants) in pesticide formulations applied to growing crops and to 

animals can be considered safe under section 408 of the FFDCA. 

Table 1. Request to Amend Dimethylaminopropylamine, isopropylamine, 

ethanolamine, and triethanolamine salts of alkyl (C8-C24) benzenesulfonic acid 

under 40 CFR 180.920 and 40 CFR 180.930 to include the following CAS Reg. Nos.

CAS Numbers Chemical Names 

12068-12-1 Benzenesulfonic acid, dodecyl-, compd. with N,N-dimethyl-1,3-

propanediamine (1:1) 

121617-08-1 Benzenesulfonic acid, 4-C10-13-sec-alkyl derivs., compds. with 

triethanolamine 

193562-36-6 Benzenesulfonic acid, C16-24-alkyl derivs., compds. with 
4 

ethanolamine (1:1) (TSCA 

26836-07-7 Benzenesulfonic acid, dodecyl-, compd. with 2-aminoethanol (1:1) 

(TSCA, DSL 

3088-30-0 p-dodecylbenzenesulphonic acid, compound with 2,2',2''-

nitrilotriethanol (1:1) 

58089-99-9 Benzenesulfonic acid, 4-dodecyl-, compd. with 2-aminoethanol 

(1:1) (TSCA, DSL 

61886-59-7 Benzenesulfonic acid, tridecyl-, compd. with 2,2',2''-

nitrilotris[ethanol] (1:1) 

61931-76-8 Benzenesulfonic acid, undecyl-, compd. with 2,2',2''-

nitrilotris[ethanol] (1:1) 

67924-05-4 Benzenesulfonic acid, 4-dodecyl-, compd. with 2,2',2''-

nitrilotris[ethanol] homopolymer (TSCA, NDSL) 

68110-32-7 Benzenesulfonic acid, 3-dodecyl-, compd. with 2-aminoethanol 

(1:1) (TSCA, NDSL 

68259-35-8 Benzenesulfonic acid, undecyl-, compd. with 2-propanamine (1:1) 

68442-72-8 Benzenesulfonic acid, dodecyl-, reaction products with 

ethanolamine (TSCA, NDSL 

68567-69-1 Benzenesulfonic acid, 4-sec-dodecyl-, compd. with 2,2',2''-

nitrilotris[ethanol] (1:1) 

68815-30-5 Benzenesulfonic acid, decyl-, branched, compds. with 

triethanolamine 

68815-35-0 Benzenesulfonic acid, tetradecyl-, branched, compds. with 

triethanolamine 

68953-98-0 Benzenesulfonic acid, dodecyl-, branched, compds. with 

ethanolamine (TSCA 

70528-84-6 Benzenesulfonic acid, dodecyl-, branched, compds. with 

triethanolamine 

72391-21-0 Benzenesulfonic acid, 4-[2,4,4-trimethyl-1-(2-

methylpropyl)pentyl]-, compd. with 2-aminoethanol (1:1) (TSCA 

84961-74-0 Benzenesulfonic acid, 4-C10-13-sec-alkyl derivs., compds. with 2-

propanamine 

85480-55-3 Benzenesulfonic acid, mono-C10-13-alkyl derivs., compds. with 

ethanolamine (REACH 

85480-56-4 Benzenesulfonic acid, mono-C10-13-alkyl derivs., compds. with 

triethanolamine 

85995-82-0 Benzenesulfonic acid, 4-C10-14-alkyl derivs., compds. with 

ethanolamine (DSL 

90194-54-0 Benzenesulfonic acid, mono-C10-13-branched alkyl derivs., 

compds. with 2-propanamine 

90194-55-1 Benzenesulfonic acid, mono-C10-13-branched alkyl derivs., 

compds. with triethanolamine 

90218-09-0 Benzenesulfonic acid, mono-C8-24-branched and linear alkyl 

derivs., compds. with ethanolamine (REACH 

90218-11-4 Benzenesulfonic acid, mono-C16-24-branched and linear alkyl 

derivs., compds. with 2-propanamine 
5 

96687-54-6 tetrapropylenebenzenesulphonic acid, compound with 2,2',2''-

nitrilotriethanol (1:1) 

99924-49-9 Benzenesulfonic acid, mono-C10-14-alkyl derivs., compds. with 

ethanolamine (TSCA 

Table 2. Request to Amend Diethanolamine salts of alkyl (C8-C24) benzenesulfonic 

acid under 40 CFR 180.920 and 40 CFR 180.930 to include the following CAS Reg. 

Nos. 

CAS Numbers Chemical Names 

67815-95-6 Benzenesulfonic acid, 4-dodecyl-, compd. with 2,2'-

iminobis[ethanol] (1:1) (TSCA, NDSL, REACH 

67889-94-5 Benzenesulfonic acid, isoundecyl-, compd. with 2,2'-

iminobis[ethanol] (1:1) 

67889-95-6 Benzenesulfonic acid, isodecyl-, compd. with 2,2'-iminobis[ethanol] 

(1:1) 

68259-34-7 Benzenesulfonic acid, undecyl-, compd. with 2,2'-iminobis[ethanol] 

(1:1) 

68478-47-7 Benzenesulfonic acid, dodecyl-, reaction products with 

diethanolamine (TSCA, NDSL, REACH 

68567-68-0 Benzenesulfonic acid, 4-sec-dodecyl-, compd. with 2,2'-

iminobis[ethanol] (1:1) (TSCA, NDSL, REACH 

68815-34-9 Benzenesulfonic acid, tetradecyl-, branched, compds. with 

diethanolamine 

68815-37-2 Benzenesulfonic acid, tridecyl-, branched, compds. with 

diethanolamine 

68891-02-1 Benzenesulfonic acid, mono-C10-16-alkyl derivs., compds. with 

diethanolamine (TSCA, NDSL, REACH 

84989-15-1 Benzenesulfonic acid, 4-C10-13-sec-alkyl derivs., compds. with 

diethanolamine 

85338-09-6 Benzenesulfonic acid, 4-C10-14-alkyl derivs., compds. with 

diethanolamine 

90194-39-1 Benzenesulfonic acid, mono-C10-13-alkyl derivs., compds. with 

diethanolamine 

90194-40-4 Benzenesulfonic acid, mono-C10-14-alkyl derivs., compds. with 

diethanolamine 

90218-08-9 Benzenesulfonic acid, mono-C8-24-branched and linear alkyl 

derivs., compds. with diethanolamine