Trit'loxysulfuron-sodium 

PC Code: 119009 

Dietary Exposure Assessment DP Barcode: 0293086 

Page: 1 of 10 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

MI: Mc;>RANDUM 

DATE: August 25, 2003 

OFFICE OF 

PREVENTION, PESTICIDES 

AND TOXIC SUBSTANCES 

SUBJIECT: Trifloxysulfuron-sodium: Acute and Chronic Dietary Exposure 

Assessments for the Section 3 Registration on Almonds, Citrus, Cotton, 

Sugarcane, and Tomato (PP# 1 F06280). 

PC Code: 119009 

DP Barcode: D293086 

REVIE:WER: Michael A. Doherty, Chemist 

Registration Action Branch 2 

Health Effects Division (7509C) 

THROUGH: Jennifer R. Tyler, Chemist 

Mohsen Sahafeyan, Chemist 

Dietary Exposure Science Advisory Council ( DESAC) 

Health Effects Division (7509C) 

and 

Richard Loranger, Branch Senior Scientist 

Registration Action Branch 2 

Health Effects Division (7509C) 

TO: Michael Doherty, Chemist 

Registration Action Branch 2 

Health Effects Division (7509C) 

Executive Summary 

Acute and chronic dietary risk assessments were conducted in order to support the 

food-use Section 3 registration requests for the new herbicide trifloxysulfuron-sodium on 

almor ds, citrus, cotton, sugarcane, and tomatoes. Exposure estimates were obtained 

from the Dietary Exposure Evaluation Model (DEEM-FCID, Version 1.30), which uses 

food consumption data from the USDA's Continuing Surveys of Food Intakes by 
T rifloxysulfuron-sodium 

PC Code: 119009 

Dietary Exposure Assessment DP Barcode: 02!13086 

Page: 1 of 10 

Individuals (CSFII) from 1994-1996 and 1998. The analyses include the highly cc:nsHrvative assum 

requested uses are treated with trifloxysulfuron-sodium and that residues of the 

herbicide are at tolerance levels. Ba·sed on these assumptions, acute and chronic ri~ k 

estimates for all of the examined population subgroups (including women of 

childbearing age, infants, and children) are less than 1% of the population-adjustE:d 

doses (PADs) and are below HE D's level of concern (1 00% of the PADs). 

I. Introduction 

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. 

For acute and chronic assessments, the risk is expressed as a percentage of a 

maximum acceptable dose (i e., the dose which HED has concluded will result in no 

unreasonable adverse health effects). This dose is referred to as the population 

adjusted dose (PAD). The PAD is equivalent to the Reference Dose (RfD) divided by 

the special FQPA Safety Factor. For acute and non-cancer chronic exposures, H ::Dis 

concerned when estimated d etary risk exceeds 100% of the PAD. References wnich 

discuss the acute and chronie risk assessments in more detail are available in HED 

SOP 99.6 (8/20/99) or on the EPA/pesticides web site: "Available Information on 

Assessing Exposure from Pesticides, A User's Guide," 6/21/2000, web link: 

http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061 .pdf 

Trifloxysulfuron-sodium is a new active ingredient in the U.S. and this is the first dietc.1ry 

risk assessment was conducted by HED. 

II. Residue Information (See the Summary of Analytical Methods and Residue Data, 

D284480, M. Doherty, 8/25/03 for detailed information) 

Trifloxysulfuron-sodium does not have any established tolerances in the U.S. Ba::;ed on 

metabolism and residue data supplied by the petitioner, HED's Metabolism Assessment 

Review Committee has determined that the residues of concern for dietary exposure are 

trifloxysulfuron- sodium, per se, in food; and the combined residues of 

trifloxysulfuron-sodium, CGA-53052, CGA-382997, and CGA-368732 in drinking at r. 

For foods, these analyses assumed that residues occurred at tolerance levels anc:l that 

100% of crops for which tolerances are being sought were treated with the herbicide. 

Residue data support the following human food tolerances: 

Almond nutmeat ....... _______________ -·-··-- ----------·-·····-·················- 0.02 ppm 

Citrus ......................................... ···----------------·------·--···············0.03 ppm 

Cottonseed ................................ ···············-·--------------------------·0.05 ppm (from 3X rate studies) 

Sugarcane .............................................................................. 0.01 ppm · 

Tomatoes ............................................................................... 0.01 ppm 

Based on field trials conductE!d at exaggerated rates or on empirical processing data, 

trifloxysulfuron-sodium will not be found at concentrated levels in any of the processed 

commodities derived from these foods; therefore, the processing factors have be•:m kept 

at 1 for all commodities in these analyses. HED notes that the residues used for 

cottonseed commodities are from field trials conducted at three times the proposE:d 
Trifloxys ulfuron-sodium 

PC Code: 119009 

Dietary Exposure Assessment DP Barcode: 0293086 

Page: 2 of 10 ------------------------------------------- ----------------------

ma>cimum application rate and their use likely results in an mctreme overestimate of 

dietary exposure for cotton. Inputs to the dietary analyses are included in Attachment 1. 

Ill. DI:EM-FCIDTM Program and Consumption lnforma1ion 

Trifloxysulfuron-sodium acute and chronic dietary exposure assessments were 

con U< ted using the Dietary Exposure Evaluation Model software with the Food 

Commodity Intake Database (DEEM-FCIDTM, Version 1.30), which incorporates 

consumption data from USDA's Continuing Surveys of Food Intakes by Individuals 

(CSFII), 1994-1996 and 1998. The 1994-96, 98 data are based on the reported 

consumption of more than 20,000 individuals over two non-consecutive survey days. 

Foods "as consumed" (e.g., apple pie) are linked to EPA-defined food commodities (e.g. 

apples, peeled fruit- cooked; fresh or N/S; baked; or wheat flour- cooked; fresh or N/S, 

baked) using publicly available recipe translation files developed jointly by USDA/ARS 

and EPA. For chronic exposure assessment, consumption data are averaged for the 

entire U.S. population and within population subgroups, but for acute exposure 

ass,ess.ment are retained as individual consumption events. Based on analysis of the 

1994-216, 98 CSFII consumption data, which took into account dietary patterns and 

survey respondents, HED concluded that it is most appropriate to report risk for the 

following population subgroups: the general U.S. population, all infants (<1 year old), 

children 1-2, children 3-5, children 6-12, youth 13-19, adultr; 20-49, females 13-49, and 

adults !50+ years old. 

For chronic dietary exposure assessment, an estimate of tt e residue level in each food 

or foocl- form (e.g., orange or orange juice) on the food commodity residue list is 

multiplied by the average daily consumption estimate for th3t food/food form. The 

resulting residue consumption estimate for each food/food 'form is summed with the 

residue consumption estimates for all other food/food formn on the commodity residue 

list ·,to etrrive at the total average estimated exposure. Exposure is expressed in mg/kg 

body weight/day and as a percent of the cPAD. This procedure is performed for each 

popula1tion subgroup. 

For ac Jte exposure assessments, individual one-day food consumption data are used 

on an individual-by-individual basis. The reported consumption amounts of each food 

item can be multiplied by a residue point estimate and summed to obtain a total daily 

pesticide exposure for a deterministic exposure assessment, or "matched" in multiple 

random pairings with residue values and then summed in a probabilistic assessment. 

The! re:;ulting distribution of exposures is expressed as a pmcentage of the aPAD on 

both a user (i.e., those who reported eating relevant commodities/food forms) and a 

per ... caoita (i.e., those who reported eating the relevant coiT'modities as well as those 

who did not) basis. In accordance with HED policy, per capita exposure and risk are 

reportE!d for all tiers of analysis. However, for tiers 1 and 2, significant differences in 

user vn. per capita exposure and risk are identified and noted in the risk assessment. 

IV. Toxicologicallnformation 

The! HI ARC met on July 1, 2003 to consider the toxicological endpoints and doses and 
Trifloxysulfuron-sodium 

PC Code: 119009 

Dietc: ry Exposure Assessment DP Barcode: :; ~93 86 

Page: 3 of 10 

other pertinent issues relating to trifloxysulfuron-sodium. A summary of the toxicoiOf:Jical 

endpoints and doses relevant to dietary exposure is presented below. 

In carcinogenicity studies in male and female rats and in male and female mice, 

trifloxysulfuron- sodium did not demonstrate any biologically significant evidence of 

carcinogenic potential. HIAHC classified trifloxysulfuron-sodium as "not likely to be 

carcinogenic to humans" according to the EPA Draft Proposed Guidelines for 

Carcinogen Risk Assessment (July 2, 1999). 

Table 1. Summary of Toxicological Doses and Endpoints Re 

Trifloxysulfuron-sodium (PC Code 1 

Exposure Jose Used in Risk Special FQPA SF* and 

Scenario Assessment, UF Level of Concern for 

Risk Assessment 

Acute Dietary Developmental FQPA SF= 1 

(females NOAEL =50 aPAD =acute RfD 

13-50) m~/kg/day FQPA SF 

UF = 100 

aPAD = 0.5 mg/kg 

Ac:ute RID =0.5 

mg/kg 

Acute Dietary NOAEL = 600 mg/kg FQPA SF= 1 

(general Ui= = 100 aPAD =acute RfD 

population) FQPASF 

At:ute RID =6.0 

mg/kg aPAD = 6.0 mg/~ 

Chronic NOAEL= 23.7 FQPA SF= 1 

Dietary mg/kg/day cPAD =chronic RfD 

(all u: = 100 FQPA SF 

populations) 

Cfuonic RfD cPAD=0.237 

= 0.237 mg/kg/day mg/kg/day 

evant to Diet· ;:try Exposure for 

9009) 

Study and T toxicological Effects 

Developmen· 

Rabbits. De' 

= 100 mg/kgJ 

increased inc 

shaped hear1 

tal Toxicity Study in 

1elopmental LOAEL 

'day based on 

:idence of abnormal 

:s in fetuses. 

Acute Neurof :oxicity Studies in 

Rats. LOAEI l. = 2000 mg/kg 

based on dec : rea,sed motor 

activity on da 1y 1 in females. 

·1ronic Toxicity/ 

:ity Study in Rats. 

Combined ~ 

Carcinogenic 

LOAEL = 99. 

on increased 

3 m~/kg/day based 

tubiJlar atrophy in 

the kidneys c 1f females 

(developing after 12 months). : : 

UF = uncertamty factor, FQPA SF = Spec1al FQPA safety factor, NOAEL = no observed adverse c:)ffect 

level, LOAEL = lowest observed adverse effect level, PAD= population adjusted dose (a= acute, c = 

chronic) RfD =reference dose, MOE= margin of exposure, LOC =level of concern, NA =Not Applicable 

NOTE: The Special FQPA Safety Factor recommended by the HIARC assume!!1 that 

the exposure databases (dietary food, drinking water, and residential) are compk te and 

that the risk assessment for each potential exposure scenario includes all metabolitHs 

and/or degradates of concern and does not underestimate the potential risk for infants 

and children. Exposure estimates based on the available residue chemistry datc:1 an~ 

unlikely to underestimate exoosure. A special safety factor to address dietary expoBure 

uncertainties is not required. 

V. Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned when di•3tary 

risk exceeds 100% of the PAD. The DEEM-FCIDTM analyses estimate the dietary 

exposure of the U.S. population and various population subgroups. The results 

reported in Tables 2 and 3 are for the general U.S. Population, all infants (<1 year old), children 1-2 
Trifloxys .llfuron-sodium 

PC C:odf : 119009 

Dietary Exposure Assessment DP Barcode: D293086 

Page: 4 of 10 

-----·---------------------------------------------------------------

6-1~ . >uth 13-19, females 13-49, adults 20-49, and adults 50+ years. 

Acute Dietary Exposure Analysis. Dietary risk estimates for all population subgroups 

are es :• than 1% of the aPAD, even at the 99.9th percentile of exposure. Based on the 

com;ervative nature of the analysis, the exposure estimate at the 95th percentile is 

recommended for regulatory purposes. Risk estimates are less than 1% of the a PAD at 

that percentile for all population subgroups. 

' 

= Table 2. Results of Acute Dietary Exposuru Analysis* 

Popul< 1tion Subgroup a PAD 95th Percentile ggth Percentile 99.9th Percentile 

(mg/kg/da 

y) 

Exposure % Exposure % Exposure % 

(mg/kg/day) a PAD* (mg/kg/day) a PAD* (mg/kg/day) a PAD* 

I U.S. 6.0 0.00024 < 1 O.OOO£i4 < 1 0.001200 <1 

ron 

·,ts (< 1 year 6.0 0.00010 < 1 0.00057 < 1 0.001800 < 1 

1 1-2 years old 6.0 0.00074 < 1 0.001 0 < 1 0.002300 < 1 

:1 3-5 years old 6.0 0.00055 < 1 0.0010 < 1 0.001200 < 1 

16-12 years 6.0 0.00036 < 1 O.OOOE.i5 < 1 0.001000 < 1 

.3-19 years old 6.0 0.00026 < 1 0.00052 < 1 0.000880 < 1 

1:0-49 years old 6.0 0.00018 < 1 0.00034 < 1 0.000770 < 1 

~; o+ years old 6.0 0.00015 <1 000 5 < 1 0.000430 < 1 

:s 13-49 years 0.5 0.00020 < 1 0.00036 < 1 0.000710 < 1 

' *Exposure est1mates are reported to 2 s1gmficant f1gures;% aPAD estimates are rounded to the nearest 

who!<:~ number. 

Chronic: Dietary Exposure Analysis. The results of the chronic dietary ex·posure analysis 

are l'eported in Table 3, below. Risk estimates are less than 1% of the cPAD for all 

popula'tion subgroups. 

Table 3. Summary of Dietary Exposure and Risk for Trifloxysulfuron-sodium * 

Population Subgroup** Acute Dietary Chronic Dietary Cancer 

(95th Percentile) 

Dietary o/oaPAD i)ietary o/ocPAD Dietary Risk 

Exposure Exposure Exposure 

(mg/kg/day) (mg/kg/day) (mg/kg/day) 

General U.S. 0.00024 < 1 0 000057 < 1 NotAppli pable 

Population - All Infants ( < 1 year old} 0.00010 < 1 0 000028 < 1 N/A N/A - Children 1-2 years old 0.00074 <1 0.000170 <1 - Children 3-5 years old 0.00055 <1 0.000140 < 1 - Children 6-12 years old 0.00036 < 1 0.000090 <1 - Youth 13-19 years old 0.00026 < 1 0.000058 < 1 - Adults 20-49 years old 0.00018 < 1 0.000042 < 1 - Adults 50+ years old 0.00015 <1 0.000042 < 1 
T rifloxysulfuron-sodium 

PC Code: 119009 

Dietmy Exposure Assessment 

Females 13-49 yecrs 

old 

0.00020 < 1 

DP Barcode: D:293086 

Page: 5 of 10 

0.000044 < 1 

*Exposure estimates are reported to 2 significant figures; % PAD estimates are rounded to the nE ~t 

whole number. 

**The values for the highest expor,ed population for each type of risk assessment are bolded. 

VI. Characterization of Jnputs/Outputs 

The assumptions regarding residue levels in these analyses are highly conservative 

(tolerance- level residues, 100% crop treated), resulting in extremely high-end )( po~;ure 

and risk estimates. Even without further refinement, these risk estimates are very low 

relative to the population- adjusted doses of trifloxysulfuron-sodium. 

VII. Conclusion 

Estimated risks from dietary exposure to trifloxysulfuron-sodium resulting from the 

requested uses on almond, citrus, cotton, sugarcane, and tomato do not exceed HED's 

level of concern for any popJiation subgroup, including women of childbearing a!;Je, 

infants, and children. 

VIII. List of Attachments 

Attachment 1. Residue level inputs used in the acute and chronic dietary exposure 

analyses of trifloxysulfuron-~ odium. 

Attachment 2. Summary of the trifloxysulfuron-sodium acute dietary exposure analysis 

results for the population subgroup Females aged 13-49 years. 

Attachment 3. Summary of the trifloxysulfuron-sodium acute dietary exposure a1r1alysis 

results for the general U.S. population and representative population subgroups •axcept 

Females aged 13- 49 years. 

Attachment 4. Summary of the trifloxysulfuron-sodium chronic dietary exposure 

analysis results for the general U.S. population and population subgroups. 

cc: M. Doherty, RAB2 RElading File 
Trifloxy~ ulfuron-sodium 

PC Cod:!: 119009 

Dietary Exposure Assessment DP Barcode: 0293086 

Page: 6 of 10 

Attc1chrnent 1. Residue level inputs used in the acute and chronic dietary exposure 

ana lys:~s of trifloxysulfuron-sodium. 

Filename: C:\My Oocuments\Chemistry Reviews\OEEM Runs\Trifloxysulfuron-sodium\1 19009.r98 

Chemical: Trifloxysulfuron-sodium 

RfD(Chronic): .237 mglkg bw/day NOEL(Chronic): 0 mglkg bw/day 

RfD(AcutE ): .5 mglkg bw/day NOEL(Acute): 0 mg/kg bw/day 

Date crea :ed/last modified: 07-18-2003/10:14:22/8 Program ver. 1.30 

Comrnent aPAD for Females 13-50 = 0.5 mg/kg; a PAD for general population = 6 mglk!J. 

EP.41, Crop Oef Res Adj. Factors Comment 

Code <:;rp Commodity Name (ppm) #1 #2 

14001)030 14 Almond 0.020000 1.000 1.000 1 F06280 

14000031 14 Almond-babyfood 0.020000 1.000 1.000 1 F06280 

14001)040 14 Almond, oil 0.020000 1.000 1.000 1F06280 

14001)04114 Almond, oil-babyfood 0.020000 1.000 1.000 1F06280 

1000 106010 Citrus citron 0.030000 1.000 1.000 1F06280 

1000·1070 10 Citrus hybrids 0.030000 1.000 1.000 1F06280 

1 000·1 080 10 Citrus. oil 0.030000 1.000 1.000 1 F06280 

9500'1280 0 Cottonseed, oil 0.050000 1.000 1.000 1 F06280; From 3X r!lte 

9500'1281 0 Cottonseed, oil-babyfood 0.050000 1.000 1.000 1 F06280; From 3X rate 

1 000'1800 10 Grapefruit 0.030000 1.000 1.000 1 F06280 

1000 1810 10 Grapefruit, juice 0.030000 1.000 1.000 1F06280 

1 000·1970 10 Kumquat 0.030000 1.000 1.000 1 F06280 

1 000·1990 10 lemon 0.030000 1.000 1.000 1 F06280 

1000:2000 10 lemon, juice 0.030000 1.000 1.000 1 F06280 

1000:200110 Lemon. juice-babyfood 0.030000 1.000 1.000 1F06280 

1000:2010 10 Lemon, peel 0.030000 1.000 1.000 1 F06280 

1000:?.060 10 lime 0.030000 1.000 1.000 1F06280 

10002070 10 lime, juice 0.030000 1.000 1.000 1 F06280 

10002071 10 lime, juice-babyfood 0.030000 1.000 1.000 1 F06280 

1000:2400 10 Orange 0.030000 1.000 1.000 1F06280 

1000:241010 Orange, juice 0.030000 1.000 1.000 1F06280 

1 000:?.41 1 10 Orange, juice-babyfood 0.030000 1.000 1.000 1 F06280 

1000:2420 10 Orange, peel 0.030000 1.000 1.000 1F06280 

1000:3070 10 Pummelo 0.030000 1.000 1.000 1F06280 

9500.3620 0 Sugarcane, sugar 0.010000 1.000 1.000 1 F06280 

9500:'1621 0 Sugarcane, sugar-babyfood 0.010000 1.000 1.000 1 F06280 

95003630 0 Sugarcane, molasses 0.010000 1.000 1.000 1 F06280 

9500::1631 0 Sugarcane, molasses-babyfood 0.010000 1.000 1.000 1F06280 

10003690 10 Tangerine 0.030000 1.000 1.000 1F06280 

1000::1700 10 Tangerine, juice 0.030000 1.000 1.000 1 F06280 

0800:1750 8 Tomato 0.010000 1.000 1.000 1 F06280 

0800::1751 8 Tomato-babyfood 0.010000 1.000 1.000 1 F06280 

0800.3760 8 Tomato, paste 0.010000 1.000 1.000 1F06280 

0800:1761 8 Tomato, paste-babyfood 0.010000 1.000 1.000 1 F06280 

0800:mc 8 Tomato, puree 0.010000 1.000 1.000 1F06280 

0800:1771 8 Tomato. puree-babyfood 0.010000 1.000 1.000 1 F06280 

08003780 8 Tomato, dried 0.010000 1.000 1.000 1F06280 

0800:1781 8 Tomato, dried-babyfood 0.010000 1.000 1.000 1F06280 

0800:179C 8 Tomato, juice 0.010000 1.000 1.000 1 F06280 
Trifloxysulfuron-sodium 

PC Code: 119009 

Dietary Exposure Assessment DP Barcode: ~93086 

Page: 7 of 10 

Attachment 2. Summary of ·:he trifloxysulfuron-sodium acute dietary exposure analysis 

results for the population subgroup Females aged 13-49 years. Due to the consmvative 

nature of the analysis, the e}(posure estimate at the 95th percentile is recommendecll for 

regulatory purposes. 

U.S. Environmental Protection Agency Ver. 1.33 

DEEM-FCID ACUTE Analysis for TRIFLO)\YSULFURON-SODIUM (1994-98 data) 

Residue file: 119009.r98 Adjustment factor #2 NOT used. 

Analysis Date: 07-29-2003/08:25:36 Residue file dated: 07-29-2003/08:19:04/8 

Daily totals for food and foodform consumption used. 

Run Comment: "aPAD for Females 13-50 = 0.5 mg/kg; aPAD for general population 

= 6 mglkg." 

================================::============================================== 

Summary calculations (per capita): 

95th Percentile 99th Percentile 99.9th Percentile 

Exposure % aRID ExposuM % aRID Exposure % aRID 

Females 13-49 yrs: 

0.000195 0.04 0.000355 0.07 0.000713 0.14 
Trifloxys .Jifuron-sodium 

PC CodEl: 119009 

Dietary Exposure Assessment DP Barcode: 0293086 

Page: 8 of 10 

Attar:hrnent 3. Summary of the trifloxysulfuron-sodium acute dietary exposure analysis 

resu1lts 1for the general U.S. population and representative pJpulation subgroups except 

FemaiElS aged 13- 49 years. Due to the conservative natum of the analysis, the 

exposUire estimates at the 95th percentile are recommended for regulatory purposes. 

U.S. Environmental Protection Agency Ver. 1.33 

DEEM-FCID ACUTE Analysis for TRIFLOXYSULFURON-SODIUM (1994-98 date) 

Resid .1e fiiH: 119009.r98 Adjustment factor #2 NOT used. 

Anal)'!:.is Date: 07-29-2003/08:28:23 Residue file dated: 07-29-2003/08:19:04/8 

Daily total!: for food and food.form consumption used. 

Run Comment: "aPAD for Females 13-50 = 0.5 mg/kg; a PAD for general population 

= 6 m,;J/kg." 

=====:===::=========================================================:::,_:=========== 

Sumn·ary ::alculations (per capita): 

95th Percentile 99th Percentile 99.9th Percentile 

Exposure %aRID Exposure %aRID Exposure %aRID 

·---------- ------ ---- --------- U.S. F:opu ~tion : 

0.000241 0.00 0.000540 0.01 0.001162 0.02 

All inf.:.nts: 

0.000096 0.00 0.000573 0.01 0.001817 0.03 

Childmn 1 ·2 yrs: 

0.000737 0.01 0.001309 0.02 0.002287 0.04 

Childmn 3 ·5 yrs: 

0.000553 0.01 0.001014 0.02 0.001961 0.03 

Childn~n 6 ·12 yrs: 

0.000359 0.01 0.000651 0.01 0.001027 0.02 

Youth 13-· 9 yrs: 

0.000261 0.00 0.000515 0.01 0.000883 0.01 

Adult!: 20- 9 yrs: 

0.000180 0.00 0.000342 0.01 0.000774 0.01 

Adult!: 50-t yrs: 

0.000153 0.00 0.000252 0.00 0.000435 0.01 
Trifloxysulfuron-sodium 

PC Code: 119009 

Dietary Exposure Assessment DP Barcode: :;~93086 

Page: 9 of 10 

Attachment 4. Summary of ·:he trifloxysulfuron-sodium chronic dietary exposure 

analysis results for the gene'al U.S. population and population subgroups. 

U.S. Environmental Protection Agency Ver. 1.30 

DEEM-FCID Chronic analysis for TRIFLO>:YSULFURON-SODIUM (1994-98 data) 

Residue file name: C:\My Documents\Che nistry Reviews\DEEM Runs\Trifloxysulfuron-sodium\119009.11'98 

Adjustmen· factor #2 NOT used. 

Analysis Date 07-29-2003/08:20:58 Residue file dated: 07-29-2003/08:19:04/8 

Reference dose (RfD, Chronic}= .237 mg/xg bw/day 

COMMENT 1: a PAD for Females 13-50 = ).5 mg/kg; a PAD for general population = 6 mg/kg. 

=============================================================================== 

Total exposure by population subgroup 

Total Exposure 

Population 

Subgroup 

mg/kg Percent of 

body wt/day Rfd 

U.S. Population (total} 

U.S. Population (spring season) 

U.S. Population (summer season) 

U.S. Population (autumn season) 

U.S. Population (winter season) 

0.000057 

0.000057 

0.000053 

0.000056 

0.000062 

Northeast region 

Midwest region 

Southern region 

Western region 

Hispanics 

Non-hispanic whites 

Non-hispanic blacks 

Non-hisp/non-white/non-black 

All infants(< 1 year) 

Nursing infants 

Non-nursing infants 

Children 1-6 yrs 

Children 7-12 yrs 

0.0000i'1 

0.0000!:4 

o.ooom.o 

0.0000!>8 

0.000075 

0.000052 

0.000062 

0.000073 

0.000028 

0.00001 1 

O.OOOC34 

0.000147 

0.0000f6 

t).000055 

C.000042 

0.000049 

Females 13-19 (not preg or nursing} 

Females 20+ (not preg or nursing} 

Females 13-50 yrs 

Females 13+ (preg/not nursing} 

Females 13+ (nursing} 

Males 13-19 yrs 

Males 20+ yrs 

Seniors 55+ 

Children 1-2 yrs 

Children 3-5 yrs 

Children 6-12 yrs 

Youth 13-19 yrs 

Adults 20-49 yrs 

Adults 50+ yrs 

Females 13-49 yrs 

0 000054 

0.000054 

0.0000()1 

0.000041 

0.000042 

0.000170 

0.00014 2 

0.0000~0 

0.0000b8 

0.000042 

0.000042 

0.000044 

0.0% 

0.0% 

0.0% 

0.0% 

0.0% 

0.0% 

0.0% 

0.0% 

0.0% 

0.0% 

0.0% 

0.0% 

0.0% 

0.0% 

0.0% 

0.0% 

0.1% 

0.0% 

0.0% 

0.0% 

0.0% 

0.0% 

0.0% 

0.0% 

0.0% 

0.0% 

0.1% 

0.1% 

0.0% 

0.0% 

0.0% 

0.0% 

0.0%