14570 Federal Register / Vol. 74, No. 60 / Tuesday, March 31, 2009 / Notices 

Licensing Status: Available for 

licensing. 

Licensing Contact: Peter A. Soukas, 

J.D.; 301–435–4646; 

soukasp@mail.nih.gov 

Radiotracers for Imaging Pglycoprotein Transporter Function 

Description of Technology: This 

invention offers technology to help treat 

certain brain diseases, such as 

Alzheimer’s disease and Parkinson’s, 

and may lead to more effective and 

personalized treatments. P-glycoprotein 

transporter (P-gp) acts as a pump at the 

blood-brain barrier to exclude a wide 

range of xenobiotics (e.g., toxins, drugs, 

etc.) from the brain and is also 

expressed in a tumor in response to 

exposure to established/prospective 

chemotherapeutics (a phenomenon 

known as multidrug resistance; MDR). 

The instant invention relates to 

compounds that are avid substrates for 

P-gp, and their preparation and use as 

radiotracers for imaging P-gp function in 

vitro and in vivo. 

Applications: These radiotracers have 

potential application for investigating 

the function of P-gp at the blood-brain 

barrier for human subjects and patients 

in relation to neuropsychiatric disorders 

and in cancer. Their application may 

lead to a better general understanding of 

the role of P-gp in the unfolding of 

certain brain diseases (e.g., Alzheimer’s 

disease, Parkinson’s disease), and 

ultimately to more effective and 

personalized treatment. Likewise, these 

radiotracers may be applied in oncology 

to help understand MDR and its clinical 

manifestation, and to help seek out 

cancer therapies that avoid MDR. 

Advantages: This class of radiotracer, 

typified by the described [11C]dLop, is 

designed to restrict the formation of 

radiometabolites that would obstruct the 

measurement of P-gp function at the 

blood-brain barrier or at tumors. In this 

sense these radiotracers are vastly 

superior to progenitors (e.g., 

[11C]verapamil, [11C]loperamide), 

which can only give qualitative not 

quantitative information. 

Development Status: Radiotracer 

studies in human subjects are in 

progress. Longer-lived versions of the 

radiotracers are in development. 

Market: These radiotracers may be of 

interest to those wishing to market and/ 

or apply such radiotracers in the 

medical imaging field. 

Inventors: Victor W. Pike, Robert B. 

Innis, Sami S. Zoghbi, and Neva 

Lazarova (NIMH). 

Publications: 

1. SS Zoghbi, JS Liow, F Yasuno, J 

Hong, E Tuan, N Lazarova, RL Gladding, 

VW Pike, RB Innis. 11C–Loperamide 

and its N-desmethyl radiometabolite are 

avid substrates for brain P-glycoprotein 

efflux. J Nucl Med. 2008 Apr;49(4):649– 

656. 

2. N Lazarova, SS Zoghbi, J Hong, N 

Seneca, E Tuan; RL Gladding, JS Liow, 

A Taku, RB Innis, VW Pike. Synthesis 

and evaluation of [N-methyl-11C]Ndesmethyl-loperamide as a new and 

improved PET radiotracer for imaging Pgp function. J Med Chem. 2008 Oct 

9;51(19):6034–6043. 

3. JS Liow, W Kreisl, SS Zoghbi, N 

Lazarova, N Seneca, RL Gladding, A 

Taku, P Herscovitch, VW Pike, RB Innis. 

P-glycoprotein function at the bloodbrain barrier imaged using 11C–Ndesmethyl-loperamide in monkeys. J 

Nucl Med. 2009 Jan;50(1):108–115. 

Patent Status: U.S. Patent Application 

No. 12/112,994 filed 30 Apr 2008 (HHS 

Reference No. E–318–2007/0–US–01) 

Licensing Status: Available for 

licensing. 

Licensing Contact: RC Tang, JD, LLM; 

301–435–5031; tangrc@mail.nih.gov. 

Collaborative Research Opportunity: 

The National Institute of Mental Health 

Molecular Imaging Branch is seeking 

statements of capability or interest from 

parties interested in collaborative 

research to further develop, evaluate, or 

commercialize radiotracers for imaging 

P-gp function. Please contact Victor Pike 

at pikev@mail.nih.gov for more 

information. 

Dated: March 24, 2009. 

Richard U. Rodriguez, 

Director, Division of Technology Development 

and Transfer, Office of Technology Transfer, 

National Institutes of Health. 

[FR Doc. E9–7213 Filed 3–30–09; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

Center for Scientific Review; Notice of 

Closed Meetings 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. Appendix 2), notice 

is hereby given of the following 

meetings. 

The meetings will be closed to the 

public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 

as amended. The grant applications and 

the discussions could disclose 

confidential trade secrets or commercial 

property such as patentable material, 

and personal information concerning 

individuals associated with the grant 

applications, the disclosure of which 

would constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: Center for Scientific 

Review Special Emphasis Panel; Molecular 

Neuroscience. 

Date: April 20–21, 2009. 

Time: 9 a.m. to 3 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institutes of Health, 6701 

Rockledge Drive, Bethesda, MD 20892 

(Virtual Meeting). 

Contact Person: Deborah L. Lewis, PhD, 

Scientific Review Officer, Center for 

Scientific Review, National Institutes of 

Health, 6701 Rockledge Drive, Room 4118, 

MSC 7850, Bethesda, MD 20892, (301) 435– 

1224, lewisdeb@csr.nih.gov. 

Name of Committee: Center for Scientific 

Review Special Emphasis Panel; Topics in 

Developmental, Cellular and Molecular 

Biology. 

Date: April 20, 2009. 

Time: 2 p.m. to 4 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institutes of Health, 6701 

Rockledge Drive, Bethesda, MD 20892 

(Telephone Conference Call). 

Contact Person: Sherry L. Dupere, PhD, 

Scientific Review Officer, Center for 

Scientific Review, National Institutes of 

Health, 6701 Rockledge Drive, Room 5136, 

MSC 7843, Bethesda, MD 20892, (301) 435– 

1021, duperes@csr.nih.gov. 

Name of Committee: Center for Scientific 

Review Special Emphasis Panel; Member 

Conflict Review for UKDG Study Section. 

Date: April 27, 2009. 

Time: 1 p.m. to 3 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institutes of Health, 6701 

Rockledge Drive, Bethesda, MD 20892 

(Telephone Conferece Call). 

Contact Person: Rass M. Shayiq, PhD, 

Scientific Review Officer, Center for 

Scientific Review, National Institutes of 

Health, 6701 Rockledge Drive, Room 2182, 

MSC 7818, Bethesda, MD 20892, (301) 435– 

2359, shayiqr@csr.nih.gov. 

Name of Committee: Center for Scientific 

Review Special Emphasis Panel. Member 

Conflict: Memory and Neuroendocrinology. 

Date: April 29, 2009. 

Time: 3 p.m. to 5 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institutes of Health, 6701 

Rockledge Drive, Bethesda, MD 20892 

(Virtual Meeting). 

Contact Person: Edwin C. Clayton, PhD, 

Scientific Review Officer, Center for 

Scientific Review, National Institutes of 

Health, 6701 Rockledge Drive, Room 50950, 

MSC 7844, Bethesda, MD 20892, (301) 402– 

1304, claytone@csr.nih.gov. 

(Catalogue of Federal Domestic Assistance 

Program Nos. 93.306, Comparative Medicine; 

93.333, Clinical Research, 93.306, 93.333, 

93.337, 93.393–93.396, 93.837–93.844, 

93.846–93.878, 93.892, 93.893, National 

Institutes of Health, HHS) 


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Federal Register / Vol. 74, No. 60 / Tuesday, March 31, 2009 / Notices 14571 

Dated: March 20, 2009. 

Jennifer Spaeth, 

Director, Office of Federal Advisory 

Committee Policy. 

[FR Doc. E9–6785 Filed 3–30–09; 8:45 am] 

BILLING CODE 4140–01–M 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

Eunice Kennedy Shriver National 

Institute of Child Health & Human 

Development; Notice of Meeting 

Pursuant to section 10(a) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. App.), notice is 

hereby given of the following meeting. 

The meeting will be open to the 

public, with attendance limited to space 

available. Individuals who plan to 

attend and need special assistance, such 

as sign language interpretation or other 

reasonable accommodations, should 

notify the Contact Person listed below 

in advance of the meeting. 

Name of Committee: National Institute of 

Child Health and Human Development 

Special Emphasis Panel Birth Defects 

Genome-Wide Association Study. 

Date: April 29, 2009. 

Time: 2 p.m. to 3:30 p.m. 

Agenda: To provide concept review of 

proposed concept review. 

Place: National Institutes of Health, 6100 

Executive Boulevard, Room 5B01, Rockville, 

MD 20852. (Telephone Conference Call) 

Contact Person: Sathasiva B. Kandasamy, 

PhD, Scientific Review Administrator, 

Division of Scientific Review, National 

Institute of Child Health, and Human 

Development, 6100 Executive Boulevard, 

Room 5B01, Bethesda, MD 20892–9304, (301) 

435–6680, skandasa@mail.nih.gov. 

(Catalogue of Federal Domestic Assistance 

Program Nos. 93.864, Population Research; 

93.865, Research for Mothers and Children; 

93.929, Center for Medical Rehabilitation 

Research; 93.209, Contraception and 

Infertility Loan Repayment Program, National 

Institutes of Health, HHS) 

Dated: March 24, 2009 

Jennifer Spaeth, 

Director, Office of Federal Advisory 

Committee Policy. 

[FR Doc. E9–7226 Filed 3–30–09; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

Eunice Kennedy Shriver National 

Institute of Child Health & Human 

Development; Notice of Closed 

Meeting 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. App.), notice is 

hereby given of the following meeting. 

The meeting will be closed to the 

public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 

as amended. The grant applications and 

the discussions could disclose 

confidential trade secrets or commercial 

property such as patentable material, 

and personal information concerning 

individuals associated with the grant 

applications, the disclosure of which 

would constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: National Institute of 

Child Health and Human Development 

Special Emphasis Panel; ‘‘The Screenable 

Disorders PAR’’. 

Date: April 30, 2009. 

Time: 1 p.m. to 3:30 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institutes of Health, 6100 

Executive Boulevard, Room 5B01, Rockville, 

MD 20852, (Telephone Conference Call). 

Contact Person: Norman Chang, PhD, 

Scientific Review Administrator, Division of 

Scientific Review, National Institute of Child 

Health and Human Development, NIH, 6100 

Executive Blvd., Room 5B01, Bethesda, MD 

20892, (301) 496–1485, 

changn@mail.nih.gov. 

(Catalogue of Federal Domestic Assistance 

Program Nos. 93.864, Population Research; 

93.865, Research for Mothers and Children; 

93.929, Center for Medical Rehabilitation 

Research; 93.209, Contraception and 

Infertility Loan Repayment Program, National 

Institutes of Health, HHS) 

Dated: March 24, 2009. 

Jennifer Spaeth, 

Director, Office of Federal Advisory 

Committee Policy. 

[FR Doc. E9–7227 Filed 3–30–09; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

National Institute of Dental & 

Craniofacial Research; Amended 

Notice of Meeting 

Notice is hereby given of a change in 

the meeting of the National Advisory 

Dental and Craniofacial Research 

Council, May 18, 2009, 8:30 a.m. to May 

18, 2009, 4:30 p.m., National Institutes 

of Health, Building 31, 31 Center Drive, 

Conference Room 10, Bethesda, MD, 

20892 which was published in the 

Federal Register on January 12, 2009, 74 

FR 1222. 

The meeting of the advisory council 

has been changed from May 18, 2009, to 

May 22, 2009. The meeting is partially 

closed to the public. 

Dated: March 20, 2009. 

Jennifer Spaeth, 

Director, Office of Federal Advisory 

Committee Policy. 

[FR Doc. E9–6783 Filed 3–30–09; 8:45 am] 

BILLING CODE 4140–01–M 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

National Cancer Institute; Notice of 

Closed Meetings 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. Appendix 2), notice 

is hereby given of the following 

meetings. 

The meetings will be closed to the 

public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 

as amended. The grant applications 

and/or contract proposals and the 

discussions could disclose confidential 

trade secrets or commercial property 

such as patentable material, and 

personal information concerning 

individuals associated with the grant 

applications and/or contract proposals, 

the disclosure of which would 

constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: National Cancer 

Institute Special Emphasis Panel, ‘‘Develop 

Automated Methods to Identify 

Environmental Exposure Patterns in Satellite 

Imagery Data.’’ 

Date: April 15, 2009. 

Time: 12:45 p.m. to 1:45 p.m. 

Agenda: To review and evaluate contract 

proposals. 

Place: National Institutes of Health, 6116 

Executive Boulevard, Rockville, MD 20852 

(Telephone Conference Call). 

Contact Person: Kirt Vener, PhD, Branch 

Chief, Special Review And Logistics Branch, 

Division Of Extramural Activities, National 

Cancer Institute, NIH, 6116 Executive Blvd., 

Room 8061, Bethesda, MD 20892–8329. 301– 

496–7174, venerk@mail.nih.gov. 

Name of Committee: National Cancer 

Institute Special Emphasis Panel, Molecular 

Oncology. 

Date: June 3–5, 2009. 

Time: 8 a.m. to 5 p.m. 


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