Amendment No. 8, dated December 21, 2007, to the Loan and Security Agreement


 EXHIBIT 10.1 
 EIGHTH AMENDMENT 
 TO 
 LOAN AND SECURITY AGREEMENT 
 THIS EIGHTH AMENDMENT to Loan and Security
Agreement (this “Amendment”) is entered into this 21st day of December, 2007, by and between Silicon Valley Bank (“Bank”) and Exelixis, Inc., a Delaware corporation (“Borrower”) whose address is 170 Harbor Way, South
San Francisco, CA 94083. 
 RECITALS 
 A. Bank and Borrower have entered into that certain Loan and Security Agreement dated as of May 22, 2002, as amended by that certain Loan Modification Agreement by and between Bank and Borrower dated as of
October 1, 2002, that certain Loan Modification Agreement by and between Bank and Borrower dated as of June 4, 2003, that certain Loan Modification Agreement by and between Bank and Borrower dated as of September 15, 2003, that
certain Loan Modification Agreement by and between Bank and Borrower dated as of February 1, 2004, that certain Loan Modification Agreement by and between Bank and Borrower dated as of December 21, 2004, that certain Sixth Amendment to
Loan and Security Agreement by and between Bank and Borrower dated as of March 29, 2006, and that certain Seventh Amendment to Loan and Security Agreement by and between Bank and Borrower dated as of December 21, 2006 (as the same may from
time to time be further amended, modified, supplemented or restated, the “Loan Agreement”). 
 B. Bank has extended credit
to Borrower for the purposes permitted in the Loan Agreement. 
 C. Borrower has requested that Bank amend the Loan Agreement to
provide for an additional equipment loan facility. 
 D. Bank has agreed to so amend certain provisions of the Loan Agreement, but
only to the extent, in accordance with the terms, subject to the conditions and in reliance upon the representations and warranties set forth below. 
 AGREEMENT 
 NOW, THEREFORE, in consideration of the foregoing recitals
and other good and valuable consideration, the receipt and adequacy of which is hereby acknowledged, and intending to be legally bound, the parties hereto agree as follows: 
 1. Definitions. Capitalized terms used but not defined in this Amendment shall have the meanings given to them in the Loan Agreement. 

 

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 2. Amendments to Loan Agreement. 
 2.1 Equipment Advances Facility D. Section 2.1 of the Loan Agreement is amended to add a new sub-section 2.1.4
to read as follows: 
 “2.1.4 Facility D Equipment Advances. 
 (a) Subject to the terms and conditions of this Agreement, Bank agrees to lend to Borrower, from December 21, 2007 through December 31, 2009
(the “Facility D Availability End Date”), equipment advances (“Facility D Equipment Advances”) in an aggregate amount not to exceed the Facility D Committed Equipment Line. When repaid, the Facility D Equipment Advances may not
be reborrowed. The proceeds of each Facility D Equipment Advance will be used solely to reimburse Borrower for 100% of the Original Stated Cost of Eligible Equipment purchased within ninety (90) days (determined based upon the applicable
invoice date of such Eligible Equipment) of the Facility D Equipment Advance. Each Facility D Equipment Advance must be for a minimum of $5,000,000. 
 (b) To obtain a Facility D Equipment Advance, Borrower will deliver a Loan Supplement to Bank in accordance with the terms and conditions set forth under Section 2.1.1(b). 
 (c) Bank’s obligation to lend under this Section 2.1.4 shall terminate on the earlier of (i) the occurrence and continuance of an Event of
Default, or (ii) the Facility D Availability End Date. 
 (d) Borrower shall have the option to prepay the outstanding amount of all
Facility D Equipment Advances so long as Borrower provides written notice to Bank of its election to prepay the Facility D Equipment Advances at least thirty (30) days prior to such prepayment. For the avoidance of doubt, the Facility A
Committed Equipment Line, the Facility B Committed Equipment Line, and the Facility D Committed Equipment Line are not subject to any prepayment penalties and any prepayment by Borrower of Facility A Equipment Advances, Facility B Equipment
Advances, and Facility D Equipment Advances shall be made in accordance with Section 2.3.1(d) of the Loan Agreement. Furthermore, with respect to Facility C Equipment Advances, Borrower may elect to prepay so long as Borrower (a) provides
written notice to Bank of its election to prepay the Facility C Equipment Advances at least thirty (30) days prior to such payment, and (b) pays, on the date of the prepayment (i) all accrued and unpaid interest with respect to the
Facility C Equipment Advances through the date the prepayment is made; (ii) all unpaid principal with respect to the Facility C Equipment Advances; (iii) an early termination fee equal to one percent (1%) of the Facility C Commitment
Equipment Line; and (iv) all other sums, if any, that shall have become due and payable in connection with the Facility C Committed Equipment Line. 
  

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 2.2 Overadvances. Section 2.2 of the Loan Agreement is hereby amended
to add sub-section 2.2(d) to read as follows: 
 “(d) If the Obligations under Section 2.1.4 at any time exceed the Facility D
Committed Equipment Line or the principal balance of the non-interest bearing certificate deposit account(s) required by Section 6.4(d) hereof at any time is less than 100% of the outstanding principal balance of the Obligations under
Section 2.1.4, then Borrower will be in an Overadvance to the extent of such excess amount. If Borrower is in an Overadvance, then Borrower shall immediately repay to Bank such excess amount.” 
 2.3 Repayment of Facility D Equipment Advances. Section 2.3 of the Loan Agreement is amended to add sub-section
2.3.1(a)(iv) to read as follows: 
 “(iv) With respect to Facility D Equipment Advances, each Facility D Equipment Advance shall
immediately amortize and be payable in 48 equal payments of principal and interest beginning on the last Business Day of the month following the Funding Date of such Facility D Equipment Advance, and continuing on the same day of each month
thereafter. The final payment due on the applicable Facility D Maturity Date shall include all outstanding principal and all accrued unpaid interest.” 
 2.4 Collateral Accounts. Section 6.4 of the Loan Agreement is hereby amended to add sub-section 6.4(d) to read as follows: 
 “6.4 Collateral Accounts. 
 (d)
Borrower will at all times maintain on deposit in a non-interest bearing certificate deposit account(s) with Bank or one of Bank’s Affiliates (and Bank or Bank’s Affiliates, as the case may be, will only allocate such deposits to a
non-interest bearing certificate deposit account) a principal balance in a value equal to at least 100% of the outstanding principal balance of the Obligations under Section 2.1.4 plus all requested Credit Extensions (other than the principal
portion of the Obligations under Sections 2.1.1, 2.1.2 and 2.1.3) (the “Facility D Collateral” and together with the Facility A Collateral, Facility B Collateral, and Facility C Collateral, the “Collateral”).” 
  

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 2.5 Amended Definitions. The following defined terms under
Section 13.1 of the Loan Agreement are each hereby amended to read as follows: 
 “Basic Rate” is (i) with respect to
Facility D Equipment Advances, 0.75% fixed, (ii) with respect to Facility C Equipment Advances, 0.85% fixed, (iii) with respect to Facility B Equipment Advances, 0.70% fixed, and (iv) with respect to Facility A Equipment Advances, the
Prime Rate, as that rate shall change from time to time. 
 “Equipment Advances” are Facility A Equipment Advances, Facility B
Equipment Advances, Facility C Equipment Advances, and Facility D Equipment Advances collectively. 
 2.6 New
Definitions. The following new defined terms are added to Section 13.1 of the Loan Agreement in alphabetical order: 
 “Facility
D Committed Equipment Line” is $30,000,000 of Facility D Equipment Advances for the financing of Eligible Equipment. 
 “Facility D
Equipment Advances” is defined in Section 2.1.4. 
 “Facility D Maturity Date” is, for each Facility D Equipment Advance,
a date which is 48 months after such Facility D Equipment Advance is made. 
 2.7 Exhibit A. Exhibit A attached
to the Loan Agreement is hereby deleted in its entirety and replaced with Exhibit A attached hereto. 
 3. Limitation of Amendments. 

 3.1 The amendments set forth in Section 2, above, are effective for the purposes set forth herein and
shall be limited precisely as written and shall not be deemed to (a) be a consent to any amendment, waiver or modification of any other term or condition of any Loan Document, or (b) otherwise prejudice any right or remedy which Bank may
now have or may have in the future under or in connection with any Loan Document. 
 3.2 This Amendment shall be
construed in connection with and as part of the Loan Documents and all terms, conditions, representations, warranties, covenants and agreements set forth in the Loan Documents, except as herein amended, are hereby ratified and confirmed and shall
remain in full force and effect. 
 4. Representations and Warranties. To induce Bank to enter into this Amendment, Borrower hereby
represents and warrants to Bank as follows: 
 4.1 Immediately after giving effect to this Amendment (a) the
representations and warranties contained in the Loan Documents are true, accurate and complete in all material respects as of the date hereof (except to the extent such representations and warranties relate to an earlier date, in which case they are
true and correct as of such date), and (b) no Event of Default has occurred and is continuing; 
 4.2 Borrower has
the power and authority to execute and deliver this Amendment and to perform its obligations under the Loan Agreement, as amended by this Amendment; 
  

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 4.3 The organizational documents of Borrower delivered by Borrower to Bank most
recently prior to the execution of this Amendment remain true, accurate and complete and have not been amended, supplemented or restated and are and continue to be in full force and effect; 
 4.4 The execution and delivery by Borrower of this Amendment and the performance by Borrower of its obligations under the Loan
Agreement, as amended by this Amendment, have been duly authorized; 
 4.5 The execution and delivery by Borrower of
this Amendment and the performance by Borrower of its obligations under the Loan Agreement, as amended by this Amendment, do not and will not contravene (a) any law or regulation binding on or affecting Borrower, (b) any contractual
restriction with a Person binding on Borrower, (c) any order, judgment or decree of any court or other governmental or public body or authority, or subdivision thereof, binding on Borrower, or (d) the organizational documents of Borrower;

 4.6 The execution and delivery by Borrower of this Amendment and the performance by Borrower of its obligations
under the Loan Agreement, as amended by this Amendment, do not require any order, consent, approval, license, authorization or validation of, or filing, recording or registration with, or exemption by any governmental or public body or authority, or
subdivision thereof, binding on either Borrower, except as already has been obtained or made; and 
 4.7 This Amendment
has been duly executed and delivered by Borrower and is the binding obligation of Borrower, enforceable against Borrower in accordance with its terms, except as such enforceability may be limited by bankruptcy, insolvency, reorganization,
liquidation, moratorium or other similar laws of general application and equitable principles relating to or affecting creditors’ rights. 
 5. Good Faith Deposit. Borrower agrees to pay to Bank a Good Faith Deposit of $50,000 (the “Good Faith Deposit”) to initiate Bank’s due diligence review process. The Good Faith Deposit is refundable if the
transactions contemplated hereunder are not approved by Bank, which approval is in the sole discretion of Bank. Otherwise, the Good Faith Deposit shall be applied to pay any Bank Expenses incurred by Bank in connection with this Amendment.

 6. Counterparts. This Amendment may be executed in any number of counterparts and all of such counterparts taken together
shall be deemed to constitute one and the same instrument. 
 7. Effectiveness. This Amendment shall be deemed effective upon
(a) the due execution and delivery to Bank of this Amendment by each party hereto, and (b) Bank’s receipt of the Corporate Borrowing Certificate substantially in the form of Exhibit B attached hereto. 
 [Signature page follows.] 
  

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 IN WITNESS WHEREOF, the parties hereto have caused
this Amendment to be duly executed and delivered as of the date first written above. 
  

									
	BANK	 		 	BORROWER
			
	Silicon Valley Bank	 		 	Exelixis, Inc.
					
	By:	 	/s/ Benjermin Colombo	 		 	By:	 	/s/ Frank Karbe
	Name:	 	Benjermin Colombo	 		 	Name:	 	Frank Karbe
	Title:	 	Deal Team Leader, Life Science Practice	 		 	Title:	 	EVP and CFO