FORM OF NON-COMPETITION & NON-SOLICITATION AGREEMENT



 Exhibit 10.46 
 NON-COMPETITION AND NON-SOLICITATION AGREEMENT 
 This Agreement is made between Elixir
Pharmaceuticals, Inc., a Delaware corporation (hereinafter referred to collectively with its subsidiaries as the “Company”), and [NAME] (the “Employee”). 
 For good consideration and in consideration of the employment or continued employment of the Employee by the Company, the Employee and the Company agree
as follows: 
 1. Non-Competition and Non-Solicitation. While the Employee is employed by the Company and for a period of [CEO: twelve
(12)][All other Executive Officers: eighteen (18)] months after the termination or cessation of such employment for any reason, the Employee will not directly or indirectly: 
 (a) Engage in any business or enterprise (whether as owner, partner, officer, director, employee, consultant, investor, lender or otherwise, except as
the holder of not more than 1% of the outstanding stock of a publicly-held company) that develops, manufactures, sells or provides any product or service that competes with any product or service developed, manufactured, marketed, sold or provided,
or planned to be developed, manufactured, marketed, sold or provided, by the Company while the Employee was employed by the Company; or 
 (b) Either alone or in association with others (i) solicit, or permit any organization directly or indirectly controlled by the Employee to solicit, any employee of the Company to leave the employ of the Company, or (ii) solicit
for employment, or permit any organization directly or indirectly controlled by the Employee to solicit for employment, any person who was employed by the Company at any time during the term of or at the time of the termination or cessation
of the Employee’s employment with the Company; provided, that this clause (ii) shall not apply to any individual whose employment with the Company has been terminated for a period of six months or longer. 
 Notwithstanding the foregoing, Section 1(a) shall not preclude the Employee from becoming an employee of, or from otherwise providing services to, a
separate division or operating unit of a multi-divisional business or enterprise (a “Division”) if: (i) the Division by which the Employee is employed, or to which the Employee provides services, is not competitive with the
Company’s business (within the meaning of Section 1(a)), (ii) the Employee does not provide services, directly or indirectly, to any other division or operating unit of such multi-divisional business or enterprise which is competitive
with the Company’s business (within the meaning of Section 1(a)) (individually, a “Competitive Division” and collectively, the “Competitive Divisions”) and (iii) the Competitive Divisions, in the aggregate,
accounted for less than one-third of the multi-divisional business or enterprises’ consolidated revenues for the fiscal year, and each subsequent quarterly period, prior to the Employee’s commencement of employment with the Division.

  







 2. Miscellaneous. 
 (a) Extension. If the Employee violates the provisions of Section 1, the Employee shall continue to be bound by the restrictions set forth in Section 1 until a period of eighteen (18) months has
expired without any violation of such provisions. 
 (b) Not Employment Contract. The Employee acknowledges that this Agreement does
not constitute a contract of employment, does not imply that the Company will continue his/her employment for any period of time and does not change the at-will nature of his/her employment. 
 (c) Successors and Assigns. This Agreement shall be binding upon and inure to the benefit of both parties and their respective successors and
assigns, including any corporation with which, or into which, the Company may be merged or which may succeed to the Company’s assets or business, provided, however, that the obligations of the Employee which are personal shall not be assigned
by him or her. Notwithstanding the foregoing, if the Company is merged with or into a third party which is engaged in multiple lines of business, or if a third party engaged in multiple lines of business succeeds to the Company’s assets or
business, then for purposes of Section 1(a), the term “Company” shall mean and refer to the business of the Company as it existed immediately prior to such event and as it subsequently develops and not to the third party’s other
businesses. 
 (d) Interpretation. If any restriction set forth in Section 1 is found by any court of competent jurisdiction to
be unenforceable because it extends for too long a period of time or over too great a range of activities or in too broad a geographic area, it shall be interpreted to extend only over the maximum period of time, range of activities or geographic
area as to which it may be enforceable. 
 (e) Severability. In case any provision of this Agreement shall be invalid, illegal or
otherwise unenforceable, the validity, legality and enforceability of the remaining provisions shall in no way be affected or impaired thereby. 
 (f) Waivers. No delay or omission by the Company in exercising any right under this Agreement will operate as a waiver of that or any other right. A waiver or consent given by the Company on any one occasion is effective only in that
instance and will not be construed as a bar to or waiver of any right on any other occasion. 
 (g) Equitable Remedies. The
restrictions contained in this Agreement are necessary for the protection of the business and goodwill of the Company and are considered by the Employee to be reasonable for such purpose. The Employee agrees that any breach of this Agreement is
likely to cause the Company substantial and irrevocable damage which is difficult to measure. Therefore, in the event of any such breach or threatened breach, the Employee agrees that the Company, in addition to such other remedies which may be
available, shall have the right to obtain an injunction from a court restraining such a breach or threatened breach and the right to specific performance of the provisions of this Agreement and the Employee hereby waives the adequacy of a remedy at
law as a defense to such relief. 
  

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 (h) Governing Law. This Agreement shall be governed by and construed in accordance with the laws
of the Commonwealth of Massachusetts (without reference to the conflicts of laws provisions thereof). 
 (i) Amendment. This Agreement
may be amended or modified only by a written instrument executed by both the Company and the Employee. 
 (j) Captions. The captions
of the sections of this Agreement are for convenience of reference only and in no way define, limit or affect the scope or substance of any section of this Agreement. 
 THE EMPLOYEE ACKNOWLEDGES THAT HE/SHE HAS CAREFULLY READ THIS AGREEMENT AND UNDERSTANDS AND AGREES TO ALL OF THE PROVISIONS IN THIS AGREEMENT. 
 ELIXIR PHARMACEUTICALS, INC. 
 Date:                                     
                          
 By:                                      
                                        

         Name: 
         Title: 
  

 
 [NAME] 
 Date:                                     
                          
 _________________________________________ 
 (Signature) 
  

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