Tri t' lox ysulfuron-sodium PC Code : 119009 Dietary Exposure Assessment DP Barcode : 0293086 Page : 1 of 10



### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460



### MI : Mc;>RANDUM DA TE: August 25 , 2003 OFFICE OF PREVENTION, PESTICIDES AND TOXIC SUBSTANCES



### S U BJ IECT: Trifloxysulfuron-sodium: Acute and Chronic Dietary Exposure Assessments for the Section 3 Registration o n Almonds , Citrus, Cotton , Sugarcane , and Tomato (PP# 1 F06280). PC Code : 119009 DP Barcode : D293086 REVIE:WER: Michael 

### A. Doherty, Chemist Reg i stration Action Branch 2 Health Effects Division (7509C) T H ROUGH: Jennifer R. Tyler , Chemist Mohsen Sahafeyan , Chemist Dietary E xposu re Science Advisory Council ( DESAC) Health Effects Division (7509C) and Richard Loranger, Branch Senior Scientist Registration Action Branch 2 Health Effects Division (7509C) TO : Michael Doherty, Chemist Registration Action Branch 2 Health Effects Division (7509C) Executive 

### Summary Acute and chronic dietary risk assessments were conducte d in order to support the food-use Section 3 registration requests for the new herb ici de trifloxysulfuron-sodium on almor ds , citrus , cotton, sugarcane , and tomatoes . Expos ure estimates were obtained from t h e D i etary E x posure E val uation Model (DEEM -FCI D, Version 1 . 30) , which uses fo o d consumpt ion data from the USDA ' s Continuing Surveys of Food I ntakes byT r i floxysulfuron-sod i um PC Code : 1 19009 Dietar y Exposure Assessment DP Barcode: 02 ! 1308 6 Page : 1 of 10 

### Individua l s (CSF II ) from 1994-1996 and 1998. The analyses include the highly cc:ns Hrvative assum requested uses are treated w ith trifloxysulfuron-sodium and that residues of the herbicide are at tolerance leve ls. Ba· sed on these assumptions, acute and chroni c**ri~ k**  

### estimates for all of the exami n ed population subgroups (including women of childbear i ng age, infants , an d children) are less than 1% of the population-adjustE : d doses (PADs) and are below HE D ' s level of concern (1 00% of the PADs) . 

### I. Introducti o n 

### Dietary risk assessment inco rporates both exposure and toxicity of a given pestic ide. For acute and chronic asses s ments, the risk is expressed as a percentage of a maximum acceptable dose (i e. , the dose which HED has concluded will result in no unreasona b le adverse health effects). This dose is referred to as the p op u lati o n adjusted dose (PAD). The P A D is equivalent to the Reference Dose (RfD) d ivi d ed by the special FQPA Safety Fac tor. For acute and non-cancer chronic exposures , H 

### ::Dis concerned when estimated d etary risk exceeds 100% of the PAD . References w n ich discuss the acute and chroni e risk assessments in more detail are available in H ED SOP 99 . 6 (8/20/99) or on the EPA/pesticides web site: "Available Information on Assessing Expos u re from Pe sticides , A User's Guide," 6/21/2000, web link: http ://www . epa . gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061 . pdf Tr ifloxysulfuron-s o dium is a n ew active ingredient i n the U . S . and this i s the first d i etc.1ry risk assessment w as conducted by HED. II . R es i due Info r m a ti o n 

### ( S ee the Summary of Analytical Methods and Residu e Data , D284480 , M . Doherty , 8/ 25/03 for detailed information) Trifloxysulfuron - sodium does not have any established tolerances in the U . S . Ba :: ; ed on metabolism and residue data supplied by the petitioner, HED's Metabolis m As s essment Review Committee has determ ined that the residues of concern for dietary exposure are trifloxysulfuron- sodium , per s e, in food; and the combined residues of trifloxysulfuron-sodium , CGA - 53052, CGA-382997, and CGA-368732 in dri nking**at r.**  

### For foods, these analyses as s umed that residues o ccurred at tolerance lev els anc:l that 100% of crops for w hich tole rances are being sought were treated w ith the herbicid e. Residue data support the foll o wing human food tolerances : Almond nutmeat .. . . . . . _ ______________ -·-· · -- - -- -

--- ---·-·····-·················- 0.02 ppm Citrus................................. ... . . . . . · · ·---------------- ·--- --

-·- -··· ··········· · 0.03 ppm Cottonseed ..... . . .. ........ ............... · · ·············-·----- --- --- ---------------·0.05 ppm (from 3X rate st u d ies) Sugarcane...... .. . .. .. .. ... . . ... . ... ... ... . . ........ ................................. .. 0.01 ppm · T o m atoes... .... .. .. . ... .. .. ....... . . . . ..... ............................... .. ..... ...... 0.01 ppm Based on field trials conductE ! d at exaggerated rate s or on empirical process i ng data , trifloxysulfuron-sodium w ill n ot be found at concentrated levels in any of the pro ce ss e d commodities deri ved from th e se foods ; therefore , the processing factors have be•:m kept at 1 for a ll commodities in th es e analyses. HED notes that the residues used f o r cottonseed commodities are from f i eld trials condu cted at three times t he p rop o sE : dTr i fl o xys u l f u ro n -sodi u m PC C od e : 119009 Diet ary Expos ure Assessme nt DP Barcode : 0293086 Page : 2 of 10



### --- --------------------- -- ---------------- - ---------------------- ma> ci m u m application rate and their use likely results in an m ctreme overestimate of dieta ry exposure for cotton. Inputs to the dietary analyses a re include d in Attachment 

## 1 . Ill . D I:EM - FCIDTM Pro g r am an d C on s um pti on lnf o rma 1i on Triflox y sulfuron-sodium acute and chronic dietary exposure assessments were**con U<** **ted** 

### using the Dietary Exposure Evaluation Model s o ftware with t he Food Co m m odity Intake Database (DEEM-FCIDTM, Version 1 . 30 ) , which incorporates con s umpt ion data from USDA's Con t i n uing Surveys of Food Intakes by Individuals (CSF II ) , 1994-1996 and 1998. The 1 994-96 , 98 data are b a sed on the reported consumption of more than 20 , 000 individuals over two non - consecutive survey days. Foods " as consumed" (e . g ., apple pie) are linked to EPA-d e fined food commodities (e.g. app les , p e eled fruit- cooked; fresh o r N/S ; baked; or wheat flour- cooked; fres h or N/S, baked ) u s ing p ublicly available recipe translation files deve l oped jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the enti re U. S . population and within popu l ation subgroups, bu t for acute exposure ass , ess.men t are ret ained as individual consumption events . Based on analysis of the 1994-21 6 , 98 CSF II consumption data , w hich took into acco u nt dietary patterns and sur v ey respo n dents , HED concluded that it is most appropriate to report risk for the foll ow ing p opulation subgroups: the general U.S. populatio n , all infants 

### (<1 year old) , children 1-2 , children 3-5 , children 6-12, youth 13-19 , adultr; 20-49, females 13-49 , and adu l ts !50+ years old. For chronic dietary exposure assessment , an estimate of tt e residue level in each food o r foo cl - form ( e.g., orange or orange juice) on the food co m modity residue list is mul t ipl ied by the average daily consumption estimate for th3t food/food form. The resulting resi d ue consumption estim a te for each food/food 'f orm is summed with the residu e consumption estimates for a ll other food/food form n on the commodity residue list · , t o etrrive at the total average estimated exposure. Exposure is expressed in mg/kg body w eigh t/day and as a percent of the cPAD . This proce d ure is performed for each popula 1 tion su b group . For ac Jte exposure assessments , indi v idual one-day food c onsumption data are used on a n i n d iv id u al-by-individual basis. The reported consum ption amounts of each food item ca n be multiplied by a residue point estimate and summed to obtain a total daily pes t ici d e exposure for a deterministic exposure assessme nt, or "matched " in multiple rando m pairings with residue values and then summed in a probabilistic assessment. The! re :;ulting distribution of exposures is expressed as a pmcentage of the aPAD on both a use r (i.e., those who reported eating relevant comm o dities/food forms) and a per... ca o ita ( i. e . , those who reported eat ing the relevant coiT'mod i ties as well as those wh o di d not) basis . In accordance w ith HED policy , per capita exposure and risk are reportE !d fo r all tiers of analysis . How e ver, for tiers 

### 1 and 2 , significant differences in use r vn . p er capita exposure and risk are identified and noted in the ris k assessment. 

### I V . Tox i c o l o g i c a ll nformat i o n The! H I A R C met on July 1 , 2003 to consider the toxicologica l endpoints and doses andTrifloxysulfuron-sod i um PC Code : 119009 D ietc: ry Exposure Assessment DP Barcode:**:; ~93** **86** Page: 3 of 10 

### other pertinent issues relatin g to trifloxysulfuron-sodium. A summary of the toxicoiO f: Jical endpoints and doses relevant to dietary exposure is presented below. In carcinogenicity studies in ma le and female rats and in male and female mice, trifloxysulfuron- sodium did n ot demonstrate any biologically significant ev idence of carcinogenic potential. HIAHC classified trifloxysulfuron-sodium as "not like l y t o be carcinogenic to humans" ac cording to the EPA Draft Proposed Guidelines for Carcinogen Risk Assessmen t (July 2, 

## 1999). Table 1. Summary of Toxicological Doses and Endpoints Re Trifloxysulfuron-sodium (PC Code 1 Exposure Jose Used in Risk Special FQPA SF* and Scenario Assessment, UF L evel of Concern for Risk Assessment Acute Dietary D evelopmen tal FQPA SF= 1 (females N O AEL =50 aPAD =acute RfD 13-50)**m~/kg/day** FQPA SF U F = 100 aPAD = 0.5 mg/kg Ac : ute RID =0.5 mg/kg Acute Dietary N O AEL = 600 mg/kg FQPA SF= 1 (general U i= = 100 aPAD =acute RfD popu l at i on) FQPASF A t:u te RID =6.0 mg/kg aPAD = 6.0**mg/~** Chronic N O AEL= 23.7 FQPA SF= 1 D ietary m g/kg/day cPAD =c hronic RfD (all 

## u : = 100 FQPA SF popu l ations) C f uonic RfD cPAD=0 . 237 = 0.237 mg/kg/day mg/kg/day evant to Diet·; :try Exposure for 9009) Study and Tt oxicological Effects Developmen· Rabbits . De' = 100 mg/kgJ increased i nc shaped hea r1tal Toxicity Study in 1elop mental LOAEL 'day based on : idence of abnormal :s in fet uses . Acute Neuro f :oxicity Studies in 

### l. = 2000 mg/kg Rats. LOAE I based on dec : rea ,sed motor activity on da 

### 1 y 1 in females. ·1ronic Toxicity/ : ity Study in Rats. Combi ned**~** Carcinogen ic LOAEL = 99. on i ncreased 3**m~/kg/day** based tubiJ l ar atrophy in 

### 1f females the kidn eys c (develo ping after 12 months). : : UF = uncertamty factor, FQPA SF = Spec1al FQPA safety factor , NOAEL = no observed adverse c: ) ffe ct level, LOAEL = lowest observed adverse effect leve l , PAD= population adjusted dose (a= acute , c = chron i c) RfD =reference dose, MOE= margin of exposure , LOC =leve l of concern , NA =Not Ap p l icable 

### NOTE: The Special FQPA Safety Factor recommended by the HIARC 

### assume!! 1 that the exposure dat abases (dietary food , drinking water, and residential) are**compk te**  

### and that the risk assessment for each potential exposu re scenario includes all metabolitHs and/or degradates of concern and does not underestimate the potential risk for infants and children. Exposure estimates based on the available residue chemistry datc: 1**an~** 

### unlikely t o underestimate exoosure. A special safety factor to address dietary expoBure uncertainties is not required. 

## V. Results/D is cuss i on As stated above, for acute a n d chronic assessments, HED is concerned when di • 3tary risk exceeds 

## 100% of the PA D. The DEEM-FCIDTM analyses estimate the dietary exposure of the U.S. popula tion and various population subgroups. The results reported in Tables 2 and 3 are for the general U.S. Population, all infants (<1 year old), children 1-2Triflo xys .llfuro n-sodi um PC**C:odf :**  119009 Dietary Exposu re Assessment DP Barcode: D293086 Page : 4 of 1 0



### -----·-------- ---- ------------------------ ---- -----------------------**6-1~ .** **>uth** 

### 1 3-19 , f emales 13-49 , adu lts 20-49, and adults 50+ years. Acu t e Die ta ry Exposure Analysis. 

### Dietary risk estimates fo r all population subg roups are**es :•**  

### than 1% of the aPAD, even at the 99.9th percentil e of exposure. Based on the com;ervat iv e nat ure of the analysis , the exposure estimate at the 95th percentile is recommended for regu latory purposes. Risk estimates are less than 1% of the a PAD at that pe r centile for a ll popu lation subg ro ups . ' = Table 2. Results of Acute Dietary Exposuru Analysis* Po p u l< 1 t i on Subgroup a PAD 95th Percenti le ggth Percentile 99.9th Percenti le (mg/kg/da y) Exposu re 

### % Expos u re % Exposure % (mg/kg/day) a PAD* (mg/kg/day) a PAD* (mg/kg/d ay) a PAD* I U.S. 6 . 0 0 . 00024 < 1 O.OOO £ i4 < 1 0 .0 01200 <1 r on

·, ts (< 1 year 6 . 0 0.00010 < 1 0.000 5 7 < 1 0 .001800 < 1 1 1-2 years old 6.0 0.00074 < 1**0.001 0**  < 1 0 . 002300 < 1 :13-5 years old 6.0 0. 00 055 < 1 0 .0 010 < 1 0 . 001200 < 1 16-12 years 6.0 0 . 00036 < 1 O.OOO E .i 5 < 1 0 . 001000 < 1

.3-19 years old 6 . 0 0. 000 26 < 1 0 . 0005 2 < 1 0 . 000880 < 1 1 :0-49 years o ld 6 .0 0.00018 < 1 0.000 34 < 1 0 . 000770 < 1**~; o+**  years old 6 . 0 0 . 0 0015 <1**000 5**  < 1 0.000430 < 1 

### : s 13-49 years 0.5 0 .00020 < 1 0.000 36 < 1 0.000710 < 1 

### ' *Exposu re est 1mates are reported to 2 s1gmficant f 1 gures;% aPAD estim ates are rou n ded to t h e nearest**who!<:~** number. 

### Chroni c: Dietary Exposure Analysis. 

### The results of the chronic dietary ex· posure analysis are l ' eported in Table 3, below. Risk estimates are less tha n 1% of the cPAD for all popula'tion subgroups. Table 3. Summary of Dietary Exposure an d Risk for Trifloxysulfuron-sodium* P opulation S u bgro u p** Acute D i etary Chronic Dietary Cance r (95th Pe rcentile) D ietary o/oaPAD i)i etary o/ocPAD D ietary Risk Exposure Exposure Exposure (mg/kg/day) ( mg/kg/day) (mg/kg/day) Gene ral U . S. 0.00024 < 1 0 000057 < 1 NotApp l i pab le Populat ion



## - A ll Infan ts ( < 1 year old} 0 .0 0 010 < 1 0 000028 < 1 N/A N/A



# - Children 1-2 years old 0 . 00074 <1 0.000170 <1



## - Ch i l dren 3-5 yea rs old 0 . 00055 <1 0 .000 140 < 1



## - Ch i l dren 6-12 years old 0 .00036 < 1 0 .000090 <1



## - Youth 13-19 years old 0.00026 < 1 0 .000058 < 1



# - Adu l ts 20-49 yea rs old 0 . 000 1 8 < 1 0 .000042 < 1



### - Ad u l ts 50+ years old 0 . 000 15 <1 0 .000042 < 1T r i floxys u l f u ron - sod i um PC Code : 

### 1 19009 D i etm y Exposu re Assessment

Fem a les 13-49 yecrs old 

### 0 . 00020 < 

### 1 DP Barcode: D :29 30 86 Page : 5 o f 1 0 

### 0 . 000044 < 

### 1



### *E

xpos ure estimates are reported to 2 significant figures ; % PAD 

### estimates are ro unded to t h e**nE ~t**  wh o l e num ber. **The va lu es f or the highest expo r, ed popu l at ion for each type of r i sk assessme n t are b ol d ed. 

### V I. Characteri zati on o f J np uts/ O ut p uts The assumptions regarding r esidue levels in these analyses are highly conserva ti ve (tolerance - level residues, 1 0 0% crop treated), resulting in extremely high-end**)( po~;ure**  

### and risk estimates. Even wi thout further refinement , these risk estimates are very low relative t o the population- a djusted doses of trifloxy sulfuron-sodium . 

### VII . 

### C o n c l us io n Estimated risks from dietary exposure to trifloxysulfuron-sodium resulting fro m the requested uses o n almond , citrus , cotton, sugarca n e, and tomato do not exceed HED ' s level of concern for any pop J iation subgroup, including women of chi l dbearin g a! ;Je , infants, a nd children. V III . 

### Lis t of Attach m e nts Attachment 1. Residue level inputs used in the acute and chronic dietary exp o sure analyses of**trifloxysulfuron-~ odium.**  

### Attachment 2. Summary of t he trifloxysulfuron-sodium acute dietary exposure a n al y sis results for the population su b group Females aged 13-49 years. Attachment 3. Summary of t he trifloxysulfuron-sodium acute dietary exposure a 1r1 al y sis results for the general U . S . population and representative population subgroups • axcept Females aged 13- 49 years. Attachment 4. Summary of t he trifloxysulfuron-sodium chronic dietary exposure analysis results f or the gene ral U.S. population and population subgroups. cc: M . Dohe rt y, RAB2 RE l ading File**Trifloxy~** ulfuron-sodium PC Cod:!: 119009 Dietary Exposu re Assessment DP Barcode : 0293086 Page: 6 of 10 

### Attc 1 ch rn ent 1. Residue level inputs used in the acute and c hronic dietary exposure**ana lys:~s**  

### of trifloxysulfuron-sodium. Filen ame : C :\My Oocuments\Chem istry Reviews\OEEM Runs\Trifloxysulfuron-sod i um \1 1 9009 . r98 Chem i ca l: T rifl oxysu lfuro n-sod i um RfD (Ch ro nic): . 237 m glkg bw /d ay NOEL (Chron i c): 0 mglkg bw /day RfD (AcutE ) : . 5 mglkg bw /day NOEL(Acute): 0 mg/kg bw /day Date c rea : ed/ last modified : 07-18-2003/10:14:22/8 Program ver. 1 . 30 Comrnent aPAD for Females 13-50 

## = 0 . 5 mg/kg ; a PAD for genera l populat ion 

## = 6 mglk! J. EP.41 , C rop Oef Res Adj. Factors Comment Code 

### < :; rp Commodity Name (ppm) #1 #2 14001)030 14 Almond 0 . 020000 1 . 000 1 . 000 1F06280 14000 031 14 Almond-babyfood 0 . 020000 1 . 000 1 . 000 1F06280 14001)040 14 Almond, oil 0 . 020000 1.000 1 . 000 1F06280 1400 1)04114 Almond, oil-babyfood 0 . 020000 1 . 000 1.000 1F06280 1000 106010 Citrus citron 0.030000 1.000 1.000 1F06280 1000 ·1070 10 Citrus hybrids 0.030000 1 . 000 1.000 1F06280 1 000 · 1 080 10 Citrus. oil 0 . 030000 1 . 000 1.000 1F06280 9500 ' 1280 0 Cotto nseed , oil 0.050000 1. 000 1.000 1F06280; From 3X r!lte 9500 ' 1281 0 Cotto nseed , o i l-babyfood 0 . 050000 1.000 1 . 000 1F06280 ; From 3X rate 1 000 ' 1800 10 Grapefruit 0 .030000 1.000 1.000 1F06280 1000 1810 10 Grapefruit , j uice 0 . 030000 1 . 000 1.000 1F06280 1 000 ·1970 10 Kumquat 0.030000 1.000 1 . 000 1F06280 1 000 ·1990 10 lemon 0 . 030000 1 .0 00 1.000 1F06280 1000:2000 10 lemon , jui ce 0.030000 1 .00 0 1 . 000 1F06280 1000:200110 Lemon. jui ce - babyfood 0 .030000 1 .000 1 . 000 1F06280 1000:2010 10 Lemon, peel 0 . 030000 1. 000 1 . 000 1F06280 1000:?. 060 10 lime 0.030000 1.000 1 . 000 1 F06280 1000 2 070 10 lime , jui ce 0.030000 1 .0 00 1.000 1F06280 1000 2 071 10 lime , jui ce-babyfood 0 . 030000 1.000 1 . 000 1F06280 1000 :2400 10 Orange 0 . 030000 1 .0 00 1 . 000 1F06280 1000:241 010 Orange , juice 0 . 030000 1 . 000 1 . 000 1F06 280 1 000:?.41 1 10 Orange , jui ce - babyfood 0.030000 1.000 1.000 1F06280 1000:242 0 10 Orange , pee l 0 . 030000 1. 000 1 . 000 1F06280 1000:3070 10 Pumme lo 0.030000 1 . 000 1 . 000 1F06280 9500 .3 62 0 0 Suga rcane , sugar 0.010000 1 .0 00 1 . 000 1F06280 9500:'1 621 0 Suga rcane , sugar-babyfood 0 . 010000 1 . 000 1 . 000 1F06280 9500363 0 0 S uga rcane , molasses 0 . 010000 1 .000 1 . 000 1F06280 9500 ::1 631 0 Suga rcane, molasses-babyfood 0 . 0 1 0000 1 . 000 1 . 000 1F06280 10003690 10 T angerine 0 . 030000 1.000 1 . 000 1F06280 1000 ::1700 10 Tangerine, ju ice 0 . 030000 1.000 1 . 000 1F06280 0800 :1750 8 Tomato 0.010000 1 .000 1.000 1F06280 0800 ::1751 8 Tomato- babyfood 0.010000 1 .000 1.000 1F06280 0800 . 3 760 8 Toma to , paste 0.010000 1 .000 1.000 1F06280 0800 :1761 8 Tomato, paste-babyfood 0 . 010000 1.000 1.000 1F06280 0800 : mc 8 Toma to , puree 0.010000 1 . 000 1 . 000 1F06280 0800:1771 8 Toma to. puree-babyfoo d 0 . 010000 1 . 000 1 . 000 1F06280 08003780 8 Toma to , dried 0 . 010000 1 .000 1 . 000 1F06280 0800 :1781 8 Toma to, dried-babyfood 0 . 010000 1.000 1 . 000 1F06280 0800:179C 8 To m ato , ju i ce 0 . 010000 1.000 1 . 000 1F06280Trifloxysu lfu ron-sodium PC Code: 

### 119009 Dietary Exposure Assessment DP Barcode:**~93 086**  Page: 7 of 

### 10 

### Attachment 2. Summary of ·:he trifloxysulfuron-sodium acute dietary exposure analysis results for the population subgroup Females aged 13-49 years. Due to the co n smvative nature of the analysis, the e }( posure estimate at the 95th percentile is recommende cll for regulatory purposes. U.S. Enviro nmental Protection Agency Ver. 1.33 DEEM -F CID ACUTE Analysis for TRIFLO) \YSU L FURON-SODIUM (1994-98 data) Residue file : 119009.r98 Adjustment factor #2 NOT used . Analysis Date: 07-29- 2003/08:25:36 Res i due file dated: 07-29-2003/08:19 :04/8 D aily totals for food and foodform consum p tion used. Run Comment: "aPAD for Females 13-50 = 0.5 mg/kg ; aPAD for general population = 6 mglkg." 

## ================================ ::============================================== Summary calculations (per capita): 95th Percentile 99th Perce nti le 99.9th Percentile Exposure % aRID Exposu M % aRID Exposure % aRID Females 13-49 yrs: 0.000195 0.04 0.000355 0 . 07 0 . 000713 0.14Trifloxys .Jifu ron -sod ium 

### PC CodE l : 119009 D i etary Exposure Assessment DP Barcode: 0293086 Page: 8 of 10 

### Attar:hrnent 3. Summary of the trifloxysulfuron-sodium acute dietary exposure analysis resu 1 lts 1 for the general U.S. population and representative pJpulation subgroups except FemaiE lS aged 

### 13- 49 years. Due to the conservative natum of the ana l ysis, the exposUi r e estimates at the 95th percenti le are recommended for regulatory purposes. U.S. Environmental Protection Agency Ver. 1 . 33 DEEM-FC I D ACUTE Analysis for TRIFLOXYSULFURON-SODIUM (1994-98 dat e) Resid .1e fiiH : 1 1 9009.r98 Adjustment facto r #2 NOT used . Anal)'! :. is Date: 07- 29-2003/08:28:23 Residue file dated: 07-29-2003/08 : 19:04/8 Da i ly total! : for food and food.form consumption used. Run Comment: "aPAD for Females 13-50 

## =0 . 5 mg/kg; a PAD for general population = 6 m , ;J/kg ." =====:===::================================= ===== == ======== =========:: :,_: =========== Sumn·ary : :alculations (per capita) : 95th Percentile 99th Percentile 99.9th Percentile Exp osure %aRID Exposure %aRID Exposure %aRID 

## ·----- --- - - ------ ---- 

# - - - -

-- - -- U.S. F:opu**~tion :**  0 .000241 0 . 00 0 . 000540 0.01 0.001162 0 . 02 All inf.:.nts : 0 .000096 0 . 00 0 . 000573 0 . 01 0.001817 0.03 Childmn 1 ·2 yrs: 0.000737 0 . 01 0 . 001309 0 . 02 0 . 002287 0 . 04 Childmn 3 ·5 yrs: 0.000553 0.01 0 . 001014 0.02 0 . 00 1961 0.03**Childn~n** 6 · 12 y rs: 0.000359 0.01 0 . 000651 0 . 01 0.001027 0.02 Youth 13- · 9 yrs : 0.000261 0 . 00 0.000515 0.01 0 . 0 00883 0 . 01 Adult!:**20- 9**  y rs: 0 . 000 1 80 0 . 00 0 . 000342 0 . 01 0 . 0 00774 0.01 Adult!: 50-t yrs : 0.000153 0 . 00 0 . 000252 0.00 0 . 000435 0 . 01Trifloxysulfuron-sodium PC Code: 119009 Dieta ry Exposure Assessment DP Barcode:**:;~93086** Page : 9 of 10 

### Attachment 4. Summary of ·:he trifloxysulfuron-sodium chronic dietary exposu r e analysis results for the gene 'al U.S. population and population subgroups . U.S. Environmental Protection Agency Ver. 1.30 DEEM-FCID Chronic analysis for TRIFLO>: YSULFURON-SODIUM (1994-98 data) Residue file name : C:\My Documents\Che nistry Reviews\DEEM Runs\Trifloxysulfuron-sodium\119009.11'98 Adjustmen · factor #2 NOT used. Analysis Date 07-29-2003/08:20 : 58 Res i due file dated: 07-29-2003/08 : 19:04/8 Reference dose (RfD , Chronic}= . 237 mg/ x g bw/day COMMENT 1 : a PAD for Females 13-50 = ).5 mg/kg ; a PAD for general population = 6 mg/kg. 

## ================================ = ============================================== Total exposure by population subgroup Total Exp osur e Population Subgroup mg/kg Percent of body wt/da y Rfd U . S . Population (total} U . S . Population (spring season) U . S . Population (summer season) U.S . Population (autumn season) U.S . Population (winter season) 0.000057 0 .000057

0 .000053 0 .000056 0 .000062 Northeast region Midwest region Southern region Western reg i on Hispanics Non-hispanic whites Non-hispanic blacks Non-hisp/non-white/non-black All infants(< 1 year) Nursing infants Non-nursing infan ts Children 1-6 yrs Children 7 - 12 yrs 0 . 0000i ' 1 0 . 0000!:4 

## o.ooom . o 0.0000! > 8 0 . 000075 0.0000 52 0.000 062 0 .000073 0.000028 0.00001 1

O.OOOC34 0.00014 7 0.0000f6 t).000055 C.000042 0.000 049 Females 13-19 (not preg or nursing} Females 20+ (not preg or nursing} Females 13-50 yrs Females 13+ (preg/not nursing} Females 13+ (nursing} Males 13-19 yrs Males 20+ y rs Seniors 55+ Children 1-2 yrs Children 3-5 yrs Children 6-12 yrs Youth 13-19 yrs Adults 20-49 yrs Adults 50+ yrs Females 13-49 yrs 0 000054 0.00 0 054 0.0000() 1 0.00004 1 0.00004 2 0.00017 0 0.00014 2**0.0000~0** 0 . 0000 b 8 0.000042 0.000042

0.000044 0.0%

0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0 . 0% 0.0% 0 . 0%

0.0% 0.0% 0 . 0% 0.0% 0.0%

0.0% 0.1% 0 . 0% 0.0% 0 . 0% 0 . 0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.1% 0.1% 0 .0% 0 . 0% 0.0% 0.0%

0.0%