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Via Federal Express United States Environmental Protection Agency - East 

# Attn: TSCA Section 8(e) Room 6428 

# ~ 111111111 1 11 1111I i 

# l~ ll IIIIIl lll l ~iil~ 1 2 ~1~~ ~~~I 1201 Constitution Avenue, NW Washington, DC 20004 Subject: Notice in Accordance with Section 8(e): Results of a Test Study in Wistar Rats with

3-Dimethyl-aminopropyl-olicacid-amid (CAS No: 109-28-4) Dear Sir/Madam: BASF Corporation and Elastogran GmbH are submitting results of a Test Study in Wistar Rats with 3- Dimethyl-aminopropyl-olicacid-amid (CAS No: 109-28-4), conducted by BASF SE, Ludwigshafen, Germany. The test substance is used as a release agent in polyurethane systems. The test compound 3-Dimethyl-aminopropyl-olicacid-amid, administration by gavage for 14 days in Wistar rats [CrI:WI(HAN) Charles River, Sulzfeld, Germany]. The test substance was administered to groups of 3 male as well as 3 female animals at dose levels of 1000 and 300 mg/kg body weight/day. The study was carried out to investigate if the animals tolerate the test article at the offered dose levels by gavage to select doses for subsequent studies. The following severe clinical signs of toxicity were observed in male animals: Dose level (mg/kg body wei htlday 0 300 1000 No. of animals/group 3 3 3 Arousal 0 1 3 Extended abdomen 0 0 1 Eylid halfclosure 0 1 3 High stepping gait 0 1 0 Labored respiration 0 1 2 Piloerection 0 1 3 Reduced general condition 0 0 3 Respiration sounds 0 1 0 Salivation 0 3 3 Found dead (day 5) 0 1 1 Sacrificed moribund 0 0 1

BASF Corporation 

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# s 100 Campus Drive Florham Park, NJ 07932 

# ~ Tel: (800) 526-1072 www.basf.com/usa 

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# BASF

The Chemical Company

United States Environmental Protection Agency — East June 9, 2008 

### Page 2 The following severe clinical signs of toxicity were observed in 

### female animals: 

### Dose level (mg/kg body weight/day) 0 300 1000 No. of animals/group 3 3 3 Abdominal position 0 1 0 Arousal 0 1 2 Extended abdomen 0 0 1 Eyfid halfclosure 0 3 2 Labored respiration 0 1 2 Piloerection 0 1 3 Reduced general condition 0 0 2 Respiration sounds 0 3 2 Salivation 0 3 3 Squatting posture 0 0 3 Found dead (day 6) 0 0 2 Sacrificed moribund 0 0 1
BASF Corporation understands that reporting of the results from this study under TSCA 8(e) is in accordance with EPA's policy. If you have any questions, please call Janet Cerra at (973) 245-6693. Sincerely,

Janet Cerra Product Regulatory Center of Expertise North America /jc

872" a No Confid Letter.doc

BASF Corporation 100 Campus Drive Florham Park, NJ 07932 Tel: (800) 526-1072 www.badcom/usa

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From: Origin ID: LKKA (973)245-6693 Janet Cerra Fuffi& BASF EWes` 100 Campus Drive 

# ~ Florham Park, NJ 07932

GL5170707l21 SHIP T0: (202) 564-8930 BILL SENDER 

### Attn: TSCA Section 8e USEPA East Room 6428 1201 Constitution Avenue, NW 

## Washington, DC 20004 Ship Date: 11JUN08 AdWgt:1 LB System#: 448753311NET8010 Accountf#: S ********* 

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