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## NE WYOR KUNIVERSIT YMEDICA L CENTE R P. 2

A private

university

in the public service Institut e o f Environmenta l Medicin e 55 0 FIRS TAVENUE , NE WYORK , N.Y

. 1001 6 AREA 21 2 340 - ANTHON YJ

. LANZ A RESEARC H LABORATORIE S A TUNIVERSIT

YVALLE Y LON G MEADO WROAD , STERLIN G FOREST , TUXEDO , N.Y

. MAI L AN D TELEPHON E ADDRESS : 55 0 FIRS TAVENUE , NE WYORK , N.Y

. 1001 6 

## i 

## 8 B H W

## I

?
MA R 

### I 3 (99 2
EP A AI R DOCKE T

Januar y30 , 198 5
Mr
. Jef f Cohe n USEP AMai l Dro p 1 2 Researc h Triangl e Park , HC 2771 1
Dea r Mr
. Cohen : Enclose d i s a cop yo f th e manuscrip t describin g th e lea d mode l an d th e mos t recen t printou t o f the.inpu t variable s and results

. Th e manuscrip t ha s no wbee n throug h severa l interna l revision s an d th e mode l itsel f ha s bee n refine d somewhat

. W e wer e abl e t o fin d a fe wmor e check s i n th e huma n dat a whic h provid e mode l validation

. W e decide d t o terminat e th e mode l a t ag e 2 0 sinc e th e bon e turnove r rat e increase s t o a half-tim e o f abou t 1 0 year s i n th e olde r adul t bu t th e progressio n t o thi s valu e i s no t wel l know n an d puttin g i n a n abrup t chang e t o 1 0 year s cause s th e mode l t o loo k quit e bump ya t whateve r ag e i s chosen

. W e hop e yo u concu r wit h thi s decision

. Asmoothe d mode l fo r olde r age s ca n b e worke d ou t i n th e futur e i f thi s i s necessary . Ane wpublicatio n byArthu r Chamberlai n appeare d i n th e lates t issu e oi Healt h Physic s an d thes e mos t recen t dat a hav e bee n incorporate d sinc e the yhel p wit h th e validation

. W e fee l th e manuscrip t i s nea r completio n an d woul d appreciat e you r comment s an d advic e a t thi s poin t s o tha t w e ca n begi n a fina l version

.

Copy : Dr
. Theodor e Knei p Sincerely ,
//jrXjyy

, l '.'; • J ' r-r - Naom i H
. Researc h Harley , Ph

.

Professo r D
. Biostatistie s Laborator y "-r i
1 O

^ 4

### FINA

L REPORT

- TOVTH E U.S
. ENVIRONMENTAL PROTECTIONAGENC Y

CONTRAC T NO
. B4.489 9

WIT H P. 3



### NE W YORK UNIVERSIT Y SCHOO L O F MEDICIN E

DEPARTMENT O F ENVIRONMENTAL MEDICIN E

o 

### f < ^

A

NINTEGRATE D METABOLI C MODE L FOR LEA D INHUMAN S O F AL L AGE S

/* * PRINCIPA L INVESTIGATORS : Naom i H . Harley , Ph.D . Theodor e H . Kneip , Ph.D .



### ~r V

D-ccemutr—3 0 , ir*. • • 1 9 0 4P. 4

A NINTEGRATE D METABOLI C MODE L FO R LEA D I NHUMAN S O F AL L AGE S
INTRODUCTIO N

METABOLI C MODE L

Th e equation s whic h ar e use d t o calculat e orga n burden s are ,P. 5

dB/d t = P - C fa s xB C b l xB " C b k xB + C s bxS + C l bxL +

C k bXK" C b u xB + F xC l g xL

dS/d t = C b s xB - C s bxS dL/d t = C b l xB - C l bxL - C j xL dK/d t - C b kxB - C k bxK

Wher e P = dail y

inpu t t o bloo di nug/da y
C b= bloo dt o skeleto nremova l rat e (day s )

= skeleto nt o bloo dremova l rat e "

= bloo dt o live r remova l rat e

= live r t o bloo dremova l rat e

= bloo dt o kidne y remova l rat e

= kidne y

t o bloo dremova l rat e

= bloo dt o urin e remova l rat e 's b
'b l
lb
'b k
'k b
'.b u l g = live r t o gastrointestina l trac t

remova l rat e " F = fractiona l uptak e fro m gastrointestina l trac t t o bloo d B,S,L, K= tota l leadconten t i nblood , skeleton , liver , kidne y

(ug )
Th e orga nburden s ar e calculate di na niterativ e manne r usin g the expression s

B(t+l)=B(t ) + dB/d t

S(t+l)=S(t ) + dS/d t

et cP. 6

Mode l Parameter s

Vahte r (1982 ) ha s show n tha t stric t qualit ycontro l i s necessar yt o insur e th e validit yo f reporte d data

. Unfortunate

ly , reporte d qualit yassuranc e i s th e exceptio n rathe r tha n th e rul e an d fo r thi s reaso n a n attemp t i s mad e t o utiliz e onl yth e huma n and baboo n studie s i n th e mode l wher e qualit ycontro l i s evident

.

Stabl e Lea d Data
. Ther e ar e numerou s measurement s o f stabl e lea d i n bloo d fo r thre e ag e group s fo r curren t stead ystat e environmenta l condi

tion s (NCH S 1982 , Vahte r 1982)

. Stabl e lea d orga n burden s hav e bee n measure d b

yBarr y(1981 ) fo r a fe wag e group s coverin g th e infan t t o th e adult

. Legott e e t al

. (1980 ) measure d dail y urinar yexcretio n i n adult s i n Ne wYor k City

. Ziegle r e t al

. (1978 ) measure d stabl e lea d i n die t and excret a i n infant s 1 4 week s t o 2 year s old

. Stabl e lea d i n huma n tissue s i s changin g wit h tim e du e t o difference s i n dietar yan d inhalatio n intake

. Value s reporte d fo r tissue s i n th e mi d 1970' s ar e summarize d i n Tabl e 1

.

Lead-21 0 Data
. Naturall yoccurrin g Pb-21 0 ha s bee n measure d i n excret a an d die t i n a controlle d metaboli c stud ya t th e Hine s Veteran' s Hospita l (Spence r et
. al

. 1977)

. Boge n e t al

. (1976 ) measure d stabl e lea d an d Pb-21 0 i n die t an d bon e as h sample s fro mNe w York

. Th e Pb-21 0 i s importan t fo r mode l validatio n i n tha t Pb

21 0 level s i n th e die t occu r naturall yand ar e no t subjec t t o ^change s ove r time

. Difference s i n Pb-21 0 intak e fo r differen t ag e group s ar e du e t o dietar yconsumption

. Th e Pb-21 0 dat a ar e als o summarize d i n Tabl e 1

.Bon e . P. 7

I t i s wel l know n tha t lea d i s associate d wit h th e minera l portio n o f th e skeleton

. Fo r thi s reason , th e remova l half-tim e fro mbon e mos t likel yreflect s bon e modelin g and remodelin g rathe r tha n a specifi c remova l rat e o f th e nuclid e fro mth e skeleton

. Thi s wa s als o th e cas e fo r fallou t Sr-9 0 whic h ha s bee n studie d extensivel yi n human s o f al l age s (Woodar d an d Harle y(1965)

. Papwort h and Vennar t (1984 ) hav e fi t a compar menta l mode l t o bon e fo r al l age s usin g measure d Sr-9 0 i n bon e and th e know n dail yintak e i n food

. The yindicat e tha t althoug h th e turnove r rat e i n trabecula r bon e i s 4 time s tha t o f cortica l bone , ther e wa s n o differenc e i n th e measure d concentrations , i n pCi/ g Ca , i n bot h type s o f bon e fo r continuou s intake

. Barr y (1981 ) indicate s tha t h e fel t hi s measure d stabl e lea d showe d n o distinctio n betwee n bon e type
. Aunifor mdistributio n wa s als o observe d fo r radiu mand uraniu mi n th e skeleto n presen t becaus e o f natura l dietar yintake

. Th e bon e remova l half-time s calculate d b

yPapwort h and Vennar t fro mth e Sr-9 0 dat a ar e smoothe d somewha t fo r us e i n thi s model

. Th e half-time s reporte d bythe m

ar e show n i n Tabl e 2 an d th e smoothe d value s use d i n thi s mode l ar e indicate d a s well

. Papwort h and Vennar t (1984 ) di d no t repor t bon e remova l half-time s fo r ove r ag e 20

. Rabinowit z e t al

. (1973 ) estimate d a bon e remova l rat e i n th e adul t o f abou t 1 0 year s and Petro w(1966 ) estimate d thi s sam e remova l rat e fro mhi s measurement s o f Pb-21 0 buil d u p fro mradium-22 6 i n forme r radiu m dia l painters

.Althoug hleadi nbon e i s no t i nstead y stat e excep t i nthe adult , i t i s possibl e t o estimat e the remova l hal f tim e fro m bloo dto bon e for the adult . P. 8

adul t skeleton dS/d t = C b s xB - C s b xS

Choosin g value s o f 95 0 an d10000 0 u

g i nbloo dan

dbon e respectivel y

fo r the adul t an dth e valu e of Cs bo f 0.000 2 pe r reporte db

y Papwort han

dVennar t at ag e 19 , a bloo dt o bon e remova l half-tim e o f 3 0 day s i s estimated . da y

Mallo n• (1983 ) wa s abl e t o measur e th e remova l half-tim e fro m bloo dt o bon e i nthe infan t baboo nfro m measurement s o f skeleta l leadan

dbloo dlead . A

half-tim e o f 2 day s fi t hi s dat a well . Fros t (1969 ) ha s measure dbon e formatio nrate s i ncortica l bon e i ninfants , childre nan dadults . Th e rati o o f bon e formatio n rat e wit hag e (Tabl e 2 ) i s use dt o scal e th e measure dremova l half-tim e fro

m bloo dt o bon e i nth e infan t baboont o obtain value s o f thi s paramete r wit hage . Th e consistenc y i ntha t the tw o method s agre e fo r the adul t valu e (2 6 vs . 3 0 days ) give s som e verificatio no f thi s technique . I na ni nviv o stud

y o f injecte dradioactiv e Pb-203 , Hear d an dChamberlai n(1984 ) measure da naccumulatio no f 2,0 % o f Pb-20 3 i nth e skeleto n2 0 day s pos t injectio nThi s valu e i s importan t fo r the mode l validation . Thes e estimate s an dal l o f th e bon e mode l parameter s a s a functiono f ag e ar e showni nTable s 2 t o 4 . Tabl e 3 i s include d t o sho w

th e skeleta l calciu m a s a functio no f age , skeleta l as h weigh t an

dthe volum e or weigh t o f the compartment s use di nthe mode l s o tha t orga nconcentratio nma y be calculated .
Kidney .

Th e kidne y

a s anorga ni s treate dseparatel y from urinar y excretion . Lea dwithi nkidne y cell s i s interna l t o th e orga nan d ha s a differen t half-tim e from the leadwhic hi s filtere dfro m plasm a an

dexcrete dvi a the tubules . No huma ndat a fo r remova l tim e fro m th e kidne y

t o bloo d exists . Strehlo w (1971 ) an

dCohen(1970 ) hav e determine dthe apparen t remova l half-tim e i nth e kidne y fo r Pb-21 0 i nth e adul t an dJuvenil e baboonrespectively . Th e valu e (1 0 days ) wa s approximatel y

th e sam e fo r al l age s ands o n o ag e differenc e i s anticipate di nhumans . Mal.lo n(1983 ) determine dtha t a kidne y t o bloo dremova l half-tim e o f 1 0 day s fo r infan t an djuvenil e baboon s provide da goo dfi t t o measure dkidne y burde ni na long ter m feedin g experiment .P. 9

Kidney(t) = 'b k
C k b " C b

. -C , t

-C , t r b k s , [ e - e ]

wher e C b = overal l bloo dremova l half-tim e (da y -1 )

- B ° = initia l tota l inpu t t o blood . Fp r an y

remova l half-tim e fo r kidne y shorte r tha ntha t fo r overal l remova l fro m blood , th e observe dhalf-tim e i nkidne y wil l b e identica l wit htha t fo r blood . Longe r half-time s tha nfo r bloo dwil l giv e apparen t half-time s whic hdepen dupo nth e relativ e remova l times .
Onc e th e remova l half-tim e fro m kidne y

t o bloo di s selecte d th e half-tim e fo r remova l fro m bloo dt o kidne y ca nb e estimate d fro m th e stead y

stat e condition s
dK/d t - C b kxB - C k bxK= 0

- C b k " ( C kb. xK > / B tl/ 2 = l n2/C b k
I nth e mode l develope dher e a kidne y t o bloo dremova l half-tim e o f 1 0 day s measure di nth e baboo ni s use dfo r al l age s a s i s th e half-tim e o f abou t 3 0 day s fo r remova l o f lea dfro m bloo dt o kidne y derive dfro m

th e abov e expression .
I nth e human , th e overal l bloo dhalf-tim e i s longe r tha n tha t o f th e baboo n(1 6 vs . 6 days ) (Mallo n1983 ) an da mor e appropriat e kidne y t o bloo dremova l hal f tim e coul dtherefor e b e an y valu e u pt o 1 6 days . Ther e i s n o effec t upo nbloo dlea da t stead y stat e a s discusse dabove , however , i t woul db e o f scientifi c interes t t o determin e thi s valu e precisely . Th e value s use di nthi s mode l ar e show ni nTabl e 4 .

Liver . Th e live r i s simila r t o kidne y i ntha t i t doe s no t affec t bloo dlea donc e stead y stat e i s achieve dan dthi s occur s quit e rapidly . Th e live r t o bloo dremova l half-tim e observe di nth e adul t an djuvenil e baboo nwa s 2 3 day s (Strehlo w 1971 , Cohe n 1970) . Mallo n(1983 ) wa s als o abl e t o fi t th e stead y stat e live rP.1 0

burde n i n juvenil e baboon s i n a lea d feedin g experimen t utilizin g thi s half-time

. Sinc e n o chang e i n half-tim e wa s see n wit h age , i t i s assume d tha t live r t o bloo d remova l half-tim e i s als o constan t wit h ag e i n th e human

.

Th e half-time s use d i nthi s mode l fo r the live r includin g biliar y

excretion , a s a functio no f ag e ar e showni nTabl e 4 .

Bloo d
A noveral l remova l rat e fro m bloo dha s bee n establishe di nth e adul t mal e i ntwo studies . Chamberlai ne t al . (1975 ) gav e radioactiv e Pb-20 3 b y inhalatio no f engin e exhaust . The y determine da bloo dclearanc e half-tim e o f 15. 8 days . Rabinowit z e t al . (1973 ) i na feedin g experimen t wit hstabl e Pb 20 4 an dPb-20 7 determine dth e overal l bloo dclearanc e half-tim e t o be 18. 7 days . Th e overal l bloo dhalf-tim e followin g a singl e injectio nchange s wit htime . Thi s ha s bee nobserve di nth e baboonstudies , bu t the huma nstudie s hav e no t bee nconducte dfo r long enoug hinterval s t o establis hthe entir e remova l curve .P.1 1

Urin e Rabinowit z et
. al

. (1973 ) showe d tha t 54 % o f th e lea d i n bloo d cleare d vi a urinar yexcretion

. Hear d and Chamberlai n (1984 ) measure d 30 % urinar yexcretio n 2 0 day s afte r injectio n o f radioactiv e Pb-203

. Thes e ar e a.usefu l value s sinc e the yca n b e use d i n th e mode l unde r singl e injectio n condition s fo r mode l validation

. Ziegle r e t al

. (1978) , measure d urinar yand feca l excretio n i n infant s 1 4 day s t o 2 year s old

. Th e urinar yexcretio n a t 1 yea r wa s abou t 1 1 ug/da y(dietar yintak e measure d a s abou t 10 0 ug/day)

. Th e urinar yexcretio n fo r adult s wa s measure d b yLegott e e t al

. (1980 ) an d wa s foun d t o b e 1 7 ug/da yo n averag e (rang e 7

- 3 1 ug/day ) (dietar yintak e 8 0 ug/day)

. Th e urinar yclearanc e half-tim e ma yb e estimate d fro ma knowledg e o f th e whol e bloo d conten t and th e urinar yexcretion

. Urin e (ug/day ) b u x B
A t on e yea r th e tota l bloo d conten t i s abou t 14 0 u g (88 0 ml

. x 0.1 6 ug/ml ) yieldin g a n excretio n half-tim e o f 9 days

. Fo r th e adul t th e tota l bloo d conten t i s abou t 95 0 u g (560 0 m l x 0.1 7 ug/ml ) whic h yield s a urinar yremova l half-tim e o f 4 0 days

. Assumin g tha t th e urinar yexcretio n i s constan t a t abou t 1 5 ug/da yfo r age s betwee n infanc yan d adulthoo d and utilizin g th e reporte d bloo d level s wit h ag e (NCH S 1982 ) additiona l excretio n half-time s ma yb e estimate d fo r a fe wag e groups . Th e value s use d fo r urinar yhalf-time s a s a functio n o f ag e ar e show n i n Tabl e 4

.
Gastrointestina l Uptake

.

dB/d t = P - C b u x B = 0

Spence r et.al

. (1977 ) measure d 1.3 6 pC i Pb-210/da yfo r th e die t plu s inhalatio n and 0.2 5 pC i Pb-210/da yi n urinar yexcretion

. Thi s yield s a valu e o f 0.25/1.3 6 = 0.1 8 fo r th e fractiona l lea d uptake

. Legott e e t al

. (1980 ) measure d 1 7 u g lead/da yi n urinar y excretio n i n adult s i n Ne wYor k Cit ywit h a dietar yintak e o f 8 0 u g lead/da y(Boge n e t al. , 1976)

. Thi s yield s a fractiona luptak e o f 0.2 0 fo r stabl e lead

. Thi s i s somewha t highe r tha n

tha t reporte d b

yRabinowit z et
. al

. (1973 ) o f 0.09 4 o r Keho e 0.0 8 (1961 ) fo r stabl e lead

. I t ha s bee n observe d tha t lea d uptak e i s a logarithmi c functio n o f th e ingeste d quantit yi n th e baboo n (Mallo n 1983)

. Lead-21 0 i n th e presenc e o f norma l lo wdietar y lea d i s predictiv e o f th e highes t uptak e sinc e ther e i s smal l mass . Thi s i s a conservativ e estimat e fo r th e adult

. Ziegle r e t al

. (1978 ) als o note d thi s effec t i n infants

. Lea d uptak e appeare d highe r fo r lo wlea d diet s (3 0 ug/day ) versu s moderat e lea d diet s (13 0 ug/day)

. Ziegle r e t al

. (1978 ) wer e abl e t o calculat e a G I uptak e facto r o f 4 0 % fo r infant s fro mthei r measurement s o f lea d i n th e die t and excreta
. Fo r th e presen t model , a valu e o f 4 0 % i s use d fo r th e infant , 1 8 % fo r th e adul t and smoothe d value s i n intermediat e ages . I t i s no t know n whethe r lea d excrete d i n bil e i s reabsorbe d wit h th e sam e uptak e a s dietar ylead , however , thi s assumptio n i s mad e i n th e mode l a s a bes t approximation

.

MODE L RESULT S AN D VALIDATIO N

tn e compartment , tne n tn e orga n concentration s to r increasin g bloo d lea d inpu t i n step s o f 1 0 ug/da yt o a maximu m o f 15 0 ug/day

.

data

. ih e amoun t accumulate d i n bon e followin g a sing l thi s mode l i s 2 0 % , whic h i s i n goo d agreemen t wit h th e measurement s o f Hear d an d Chamberlai n (1984)

.

1 0P.1 3

Acknowledgement

. Th e author s woul d lik e t o than k Dr
. Hele n Woodar d fo r he r comment s and advic e concernin g th e model , Gordo n Coo k fo r th e illustration s and Aime e Mirand a fo r preparatio n and typin g o f th e text
.

1 1P. M

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Petrow , H C Astud yo f th e distributio n o f Ra-226 , Ra-228 , Pb- " 21 0 an d Th-22 8 i n bon e and sof t tissu e o f rado n dia l painters

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. Nationa l Swedis h Inst , o f Environmenta l Medicine , Stockholm , 198 2

1 3P.1 6

Woodard , HQ.. , Harley , JH , patient s wit h sarcoma . Healt h Physic s 11 , 991 , 196 5 Strontium-9 0 i n th e lon g bone s o f

Ziegler , EE„ , Edwards , BB
. Jensen , RL. , Mahaffey , KR. , Fomon , SJ
. Absorptio n an d retentio n o f lea d b yinfants

. Pediatri c Res
. 12,29:197 8

1 4Tabl e 1 . Typica l Stabl e Lea dan dLead-21 0 i nHuma nTissue s an dDie t

Ag e Group (1 )

Blood pg/m l (Rib ) Bon e (2 ) (2 ) (2 ) (Tibia ) (Calvaria ) Live r Kidne y pg/gas h( g wet ) pg/ g (3 ) Urin e (pg/day ) (4 )

Die t + Inhalatio n (pCi/day ) ph-?i n (5 ) Bon e (pCi ) (4 )

• Urin e (pCi/day )

0 - 1 yea r 6 n o - 5 year s 0.1 6 6. 0 (0.9 ) 5. 5 ( 0.82 ) 4. 1 ( 0.61 ) 0.4 1 0.2 1 1 1

1 - 5 yea r 1 1 (2.6 ) 1 2 ( 2.8 ) 9. 8 ( 3.1 ) 0.6 5 0.4 9

6 - 9 yea r 8. 5 (2.1 ) 11. 7 ( 2.7 ) 12. 1 ( 3.8 ) 0.7 4 0.4 6

1 1 - 1 6 yea r 6-1 7 yea r 1 8 - 7 4 yea r 0.1 3 0.1 7 8. 5 (2.1 ) 11. 5 ( 2.7 ) 12. 8 ( 4.0 ) 0.5 7 0.4 6

Adul t me n3 7 (8.8 ) 9 8 (23 ) 6 4 (20 ) wome n2 8 (6.8 ) 6 9 (16 ) 5 1 (16 ) 1.0 3 0.6 4 1 7 Rang e (7-31 ) 1.3 6 40 0 ± 5 0 (nonsmokers ) 0.2 5

(1 ) Nationa l Cente r fo r Healt hStatistic s 1976-198 0 BloodLea dLevel s (2 ) Barry

PS I Brit . J . In

dMe d38 , 6 1 (1981 ) (3 ) Ziegle r e t a l Ped . Res . 12 , 2 9 (1978) ; Legott e PA , Ros a WC , Sutto nD C Talant a 27 , 3 9 (1980 ) (4 ) Spence r e t a l 197 7 (5 ) Holtzma nRB , Ilcewlt z F H (1966 )

T JP.1 8

Tabl e 2, Bone - Formatio n an d Turnove r Rate s

Ag e
1 2 3

. 4 5 6 7 8 9 1 0
1 1 1 2 1 3 1 4 1 5 1 6 1 7 1 8 1 9 2 0
2 1 2 2 2 3 2 4 2 5 2 6 2 7 2 8 2 9 3 0
3 1 3 2 3 3 3 4 3 5 3 6 3 7 3 8 3 9 4 0 

## ( D

Remova l Hal f Tim e (Days )
113 5 78 4 67 7 65 9 71 5 88 8 132 0 258 0 873 0 oo0 0
3616 7 684 2 342 1 238 8 202 5 193 0 198 0 206 6 211 0 211 0

_ ' —

-

-

-

-
—

-

—

-

—
—
—
—
—
—
—
—

-

- Mode l

(Smoothe d Values ) Day s
113 5 113 5 113 5 113 5 113 5 113 5 132 0 258 0 258 0 258 0
258 0 258 0 342 1 342 1 342 1 342 1 342 1 342 1 342 1 342 1
342 1 342 1 342 1 342 1 342 1

. 342 1 342 1 342 1 342 1 342 1
365 0 365 0 365 0 365 0 365 0 365 0 365 0 365 0 365 0 365 0 (2 )

Bon e Formatio n Rat e (%/Year )
8 5 3 8 3 8 3 8 3 8 3 8 3 8 3 8 3 8 2 1
2 1 2 1 2 1 2 1 2 1 2 1 2 1 2 1 2 1 6. 7
6. 7 6. 7 6. 7 , 6. 7 6. 7 6. 7 6. 7 6. 7 6. 7 3. 5
3. 5 3. 5 3. 5 3. 5 3. 5 3. 5 3. 5 3. 5 3. 5 3. 5 (3 )

Bloo d t o Bon e Half

Tim e (Days )
2. 3 5. 2
t i n I I

n

• t i t
t i 9. 4
9. 4 i t i t

n i i
I I
t i it
I I 29. 3 29(4 )
29. 3
n I I

• t
I I it
t t it it 56. 1

• t it it i i
i t
I I it
tt n n (1 ) Papwort hDG , Vennar t J Phy s MedBio l 29 , 104 5 198 4 (2 ) Fros t H

M Calcifiedtissue Researc h3 , 21 1 (1969 ) (3 ) Ag e 1 fro

m Mallon(1983 ) fo r infan t - othe r value s scaledfro

m formationrate s o f fros t (1969 ) (4 ) Calculate dfro m adul t data , se e tex tWK J
o B JhO H g S U ) ^ J s- s o i- h O J C O Tf t, ro H 0 0 3 * r t O i- h s M r t n s * to \~- M
^ \ V O •p * L n N. X »* 1 H O 3 M n 

## g N > U J M V O

p »

o 4 o 3 NJHMI-'l-'Ht-'MH'l-'h- ' OVOOONIOIUI^WNJPOVOOOVI^I^^ WMl- J > O Q ft )

OlWWU>Ul*>*>tOOJUJtON3N»N5l-«l- i H'l-'H ' O^O^^WOO^tOvlWOOOtnWOOOO^J^>WI- l O O SIOOOHOM^UW*>«5HNJ(OOWOCO*>4NO O 

### ooooooooooooooooooo o

MOOOOOOOOOOOOOOOOOO O o*vovoooooM(^UlUlW^^U)U^l^J^J^o H OCOOM*)iON)*»ON\04NOWI-'(MJOOO\*-Oa i

OOO«0000N(HUlt>MJWIOIOIOIOPI- l h ' 00slt>v4V0OHNWWOJ>O0»^IOO00^ O OOOW4^CT«*«*»VOWOOOOOOOOO O

NJNNNJNNHHHH H vo_vo_00„CT v4>

. f-VO_0>.*»-.hO-0-VO-00-^l-<T > Ui-Ln-4 > 4 > ho — HOOUtOOOWvOOiLnNlNOHOOvD^OJO N OOOOOOOOOOOOOOOOOOlJi O w M o o r-s o. & « ^ o I - 1 

# i

* 1 ^ O J o O H r t 0 0 H - O J o 3 o H i > a. c l- tw o

r t TT

K N J

P Q s—\ > w 0 ) — TT Cf

l J * " ro M ro r t o 3 H O J c r ro

M o o a. < o c 3 ro
P J 3 a. o H 0 0 0 > 3 O i- l o
r t 3 "
•T J P J r t r t ro H 3 c o
O J cn

C 3 O r t H O 3 O t-h > O Q roP.2 0

4 0

- "i. a

Tabl e 4

. Hal-f—Tim e i n Day s -fo r th e Compartment ;

AG E
1. 0 2. 0 3. 0 4. 0 5. 0 6. 0 7. 0 5. 0 9. 0 • 10. 0 11- 0 12. 0 13. 0 14. 0 15. 0 16. 0 17. 0 18. 0 19. 0 20. 0 SOK E ! N

2. 3 5. 2
5. 2 5. 2 5. 2 5. 2 5. 2 5. 2 5. 2 9. 4 9. 4 9. 4 9. 4 9. 4 9. 4 9. 4 9. 4 9. 4 9. 4 BON E OU T
113 5 113 5 113 5 113 5 113 5 113 5 132 0 255 0 258 0 253 0 253 0 258 0 342 1 342 1 342 1 342 1 342 1 342 ! 342 1 342 1 LIVE Ri N

10. 0 10. 0 10. 0 10. 0 10. 0 10. 0 10. 0 10. 0 10. 0 • 10. 0 10. 0 10. 0 10. 0 10. 0 10. 0 10, 0 10. 0 10. 0 10. 0 10. 0 LIVE ROU T

23. 0 23. 0 23. 0 23. 0 23. 0 23. 0 23. 0 23. 0 23. 0 23. 0 23. 0 23. 0 ">^ rt 23. 0 23. 0 23. 0 23. 0 23. 0 23. 0 23. 0 KIDNE YI N

30. 0 30. 0 30. 0 30. 0 30. 0 30. 0 30. 0 30. 0 30. 0 30. 0 30. 0 30. 0 30. 0 30. 0 30. 0 30. 0 30. 0 30. 0 30. 0 30. 0 KIDNE YOU T

10. 0 10. 0 10. 0 10. 0 10. 0 10. 0 10. 0 10. 0 10. 0 10. 0 10. 0 10. 0 10. 0 10. 0 10. 0 10. 0 10. 0 10. 0 10. 0 10. 0 URIN E QLi

T
9. 0 9. 0 9. 0 9. 0 10. 0 10. 0 10. 0 10. 0 10.0 . 20. 0 20. 0 20. 0 20. 0 20. 0 40. 0 40. 0 40. 0 40. 0 . 40. 0 40. 0 LIVE RT Q BU T

3. 0 5. 0 5. 0 5. 0 10. 0 20. 0 40. 0 40. 0 40. 0 40. 0 40. 0 40. 0 40. 0 40. 0 60. 0 60. 0 60. 0 60. 0 60. 0 60. 0 6 1 UPTAK E

0.4 0 0.3 0 . 0.3 0 0.3 0 0.3 0 0.3 0 0.1 8 0.1 8 0.1 3 0.1 8 0.1 B 0.1 8 0.1 8 0.1 8 0.1 8 0.1 6 0.1 8 0.1 8 0.1 8 0.1 3P.2 1

20:41:2 1 01-29-198 5 Tabl e 5

. Tota l Lea d Orga n Conten t i n Microgram s fo r Males

.

Inpu t t o Bloo d 1 0 Microgram s pe r Day
.

G E

1 2 3 4 5 6 7 8 9 1 0 1 1 1 2 1 3 1 4 1 5 1 6 1 7 1 8 1 9 2 0 BLOO D

26.1 3 46.0 6 49.0 7 51.7 6 58.0 5 63

. B 4 66.9 8 57.6 1 59.5 2 72.9 7 108.1 8 110.6 9 103.9 3 105.9 7 131.7 1 135.1 3 138.4 6 141.7 1 144.8 9 147.9 9 BON E

239 8 386 3 518 2 636 3 757 4 879 2

. 1016 7 1187 1 13494 1555 8 1682 6 18075 1948 0 2082 8 2269 1 2455 4 2637 2 2814 6 2987 7 3156 7 LIVE R

6. 9 18. 9 20

. 1 21. 2 40. 4 68. 2 97. 6 84. 0 86. 8 106. 3 157. 8 161. 4 151. 6 154. 6 218. 6 224. 3 229. 9 235. 3 240. 6 • 245. 7

. • KIDNE Y

8. 7 15. 3 16. 3 17. 2 19. 3 21. 2 22. 3 19. 2 19. 8 24. 3 36. 0 36. 9 34. 6 35. 3 43. 9 45. 0 46

. 1 47. 2 48. 3 '•49. 3 URIN E

2.0 1 3

. 5 5 3.7 8 3.9 9 4.4 7 4.4 3 4.6 4 3.9 9 4

. 1 3 5.0 6 O
. 7 5 3.8 4 3.6 0 3.6 7 4.5 6 2.3 4

• 2.4 0 2.4 6

. ' 2.5 1 2.5 6 FECE S

0.9 6 0.4 6 0.4 9 0.5 2 0.9 8 1.6 5 0.9 2 0.8 0 0.8 2 1.0 1 1.4 9 1.5 3 1.4 4 1.4 6 2.0 7 2

. 1 2 2

. 1 8 2.2 3 2.2 8 2.3 3P.2 2

Tabl e 6

. Orga n Lea d Concentratio n fo r

Inpu t t a Bloo d 1 0 u g pe r da y Male s a s a Functio n o f Ag j

AG E BLOO D ug/m l

1 2 3 4 5 6 7 8 9 1 0 1 1 1 2 1 3 1 4 1 5 1 6 1 7 1 8 1 9 2 0 0.03 0

0.04 0 0.03 7 0.03 5 0.03 6 0.03 5 0.03 3 0.02 5 0.02 3 0.02 6 0.03 5 0

. 03 3 0.02 8 0.02 5 0.02 8 0.02 7 0.02 6 0.02 6 0.02 6 0.02 7 BON E ug/ g as h

8.8 7 9.5 3 10.6 5 11.7 7 12.7 4 13.5 5 14.4 7 14.6 4 14.6 8 14.3 9 13.4 5 12.4 1 11.5 5 10.7 9 10.4 2 10

. 1 6 10.0 3 10.0 1 10.3 3 10.8 1 LIVE R ug/ g

0.0 3 0.0 6 0.0 5 0.0 5 0.0 8 0

. 1 2 0

. 1 6 0

. 1 2 0

. 1 1 0

. 1 3 0

. 1 7 0

. 1 6 0

. 1 4 0

. 1 2 0

. 1 6 0

. 1 5 0

. 1 5 0.1 4 0

. 1 4 0

. 1 4 KIDNE Y ug/ g

0

. 1 8 0.2 6 0.2 3 0.2 2 0.2 3 0.2 1 0.2 1 0.1 6 0

. 1 5 0

. 1 6 0.2 2 0.2 1 0

. 1 7 0

. 1 6 0

. 1 8 0

. 1 7 0.1 7 0

. 1 6 0.1 6 0

. 1 6O > 0 C Dvl t hc nJ » C Jt o •- * O « 0 O Dv l t hUI • > oi

to »- *

t o t o to to to t

o t o I JIO W H H Hi
- H H H <JODCDv|vlchf-*otO»-'ji»-*s-*OltO>--0>0«-OU l LHO C- 4 thO C- J«- * v l *-• t hLH«t ) U l C

Jv l C h0 4 0 0 M t O

- 0 v l J i > 0 t-

0 4= . > 0 COO

JO J- OO1 0 > 0 t h• - U l H - i-* t o v l v l 0 4 t-

0 U l 1 0 0 1 U l COC

hU l - > t Oth» 0 O O I J i t- 0 CH

C hLHU l LHJ i J» J i O

JO JO JO Jt O M 1 0 f- • - f *- O JOt ht- 0 - 0 U l «-• • C DC h0 4 »- . t

h0 4 O v l UI 1 0 O v

l Ji H ' v | M vl i
- 0 4 t

hO » - t hf > 0 vl O

JC H» - vl O Jv l v | 0 4 Ul -O J i O C OUl U I U I Ul • - C

OJi O JC OJ > t O C ht-0 > 0

- > J > » - C-

JC DO Jv j O»- • t-0 t hC Ot- 0 tf l J » > 0 t hU I t hU l

J i J » J » J s J i J a O J0 4 0 4 0 4 t- 0 t - *• * i- • -

- 0 O Dv l tfl J » O

JO O 1 0 i
- »-

* v l thO 0 4 COJ i J» C-

4 » - •-* • »- * O OCOv l ^ C-

4 t- 0 U l t O0 4 v j tf

l t hO M O vl O J cn» - t hvl C ht o t o M • £ tf l v l c n- 0 *• OJO OU I O JC O< J

- 0 < J> G« 0 O

C Ov l t hv l v l J i 0 4 0 4 J i .*» C- 4 C- 4 0 4 0 4 • - C DC hJ i t-0 Ov l O - OC- 4 t-0 0 0 OC OJ i t- 0 C OJ i t OO v l t hU l J > t OO v l C ht-0 v j t- t ht hJ i C hU I t h- > t h0 - O J

CHLHJiJiJi-OvlvlvIvlOOOvl^jtDtDvlvlvlj s *- O O 0 0 C

h» - O Jt O t hC H » - M < l t OC D* 0 <3 c no o O Jt o »- * O O D O Jc nO v l o w c n- 0 -O U l J i vl C

hM JM i a > I 0 1 i m

I ! H C

J c r t-m n s v l

J » J > J i J s J s J s 1 0 t O0 4 t- 0 M 0 4 O O t hU l J i 0 4 M

H » * 0 COO > 0 O C

hU l CD0 4 -0

O O > 0 O t hC hC ht hc nJi 0 1 v ] t

hO »- • Ji o c n•- • C hO JC O to to i r

1 o 1 o 1 D

1 w 1 o 1 z i m

i r 1 H H i < i m 1 33

1 X 1 »- < 1 D 1 z i m i - <

1 c 1 3 ? 1 n 1 z i m

i - n i m i r o i m 1 U J *-*

-i 3 0 nrtC £ U r + i - n- r o ra a •C d Q

. w 0 c o -\ o n e m t o 3

~ n z 0 ^ - D n r r Tn s 0 3 0 3 r r T 3 ; >-• • 3 3 U i Z

- a M m n TT 0 Oi Q Q J ~

- < fli
•3 Ul

- h 0 T 3 S J I— » r o U l
•

-P.2 4

Tabl e 8

. Orga n Lea d Concentratio n fo r Male s a s a Functio n o f Age
.

Inpu t t o Bloo d 2 0 :u g pe r day

.

AG E BLOO D ug/m l BON E ug/ g as h LIVE R ug/ g KIDNE Y ug/ g

1 2 3 4 5 6 7 8 9 1 0 1 1 1 2 1 3 1 4 1 5 1 6 1 7 1 8 1 9 2 0 0.05 9

0.08 1 0.07 3 0.07 0 0.07 3 0.06 9 0.06 5 0.05 0 0.04 6 0.05 2 0.07 0 0.06 6 0.05 6 0.05 0 0.05 7 0.05 3 0.05 2 0.05 2 0.05 3 0.05 4 17.7 4

19.0 6 21.3 1 23.5 4 25.4 8 27.1 1 28.9 4 29.2 8 29.3 7 28.7 8 26.8 9 24.8 2 23

. 1 0 21.5 9 20.8 3 20.3 2 20.0 6 20.0 3 20.6 6 21.6 3 0.0 5 0

. 1 1 0

. 1 0 0

. 1 0 0

. 1 7 0.2 4 0.3 2 0.2 4 0.2 3 0.2 5 0.3 4 0.3 2 0.2 7 0.2 5 0.3 1 0.3 0 0.2 9 0.2 9 0.2 9 0.2 9 0.3 6

0.5 1 0.4 5 0.4 4 0.4 6 0.4 3 0.4 1 0.3 1 0.2 9 0.3 2 0.4 4 0.4 2 0.3 5 0.3 2 0.3 6 0.3 4 0.3 3 0

. 3 3 0

. 3 3 0

. 3 3

### ooc ov i t hc nJ i O J

### r o.- * o oc ov i t hc n-*

> c- i t o>-•

J s J * J s J s J s 0 4 0 4 0 4 0 4 0 4 t-3 H * >-• • t O «- * •- » »- • ^ "- * J i O J t- 0 »- • O < J H » •-• O J t O •- » v l v l O > 0 v l U l J i 0 / v l 

### o i j s u i cnu i c nvi»
- t o. > c oc ot oo *•* ' J * 

### c nv i c oc o

- oth»-• O JO J» - - ov j o cn- ocnc o- oc n^ t ot o*•* • O J t hC hJ i C O C O C-

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- o oo c o v i v i tht hc nc nc nJ i J > o i o i MN^'^ H Ji O Ji « 0 O

J C D M C O Ji O t

h O U I O t h t O O UI »•

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s 1 0 J i t h Js t h c n 0 4 v l O U I U I H * O O J 0 1 t

- C

h v j C D 0 4 t- 0 v j v l C O v - O v l t O C O - > C O O 

### o » - vi c nto j i c no c ho o Ji O JO J

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v j v l v j ( ht h C hJ i J s J s J s 0 1 t O t- 0 t- 0 I O »- » 0 1 t o O 0 0 v

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0 C ht hui t o vl H ^ U1 O t-

0 tf l C- 4 Js Js 0 4 O O ^ t

O J i » - 0 4 O C

hO t- 0 v l C O t>

- 0 > 0 C D C O 0 4 OJ O O J - 0 v l U l t O v j j s v l 0 0



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v l v l v l v l v | O l »-" • O • * f U I M t- » 0 4 0 4 0 4 •-*»- • O Ch 

### Chcn0 4 t oOCho c ocnt o^ 0 4 OO M J i - 0 0 4 Cho « 0 0 4 v l O t O - O t-

0 H * i

- U l v l C D C O OJ C O — C h J a J i J s



### t hthChChC ht hJ i J s J » J s 0 4 r ot ot oJ » t o»- • »- * »•* • t o

- 0 C D t h U I 04 t-0 0 4 c-

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4 v l - C < J c n J i 04 O

D C0Ji<l01vlf-O.-'N0CD!0vJ>0vlChJiCnvl000 0 1 2 > 1 Q i m

1 G J i r i a 1 o i D

1 C O 1 o i ^ i m

i r i f- i

• Ji m i 3 1

1 K 1 w i a 1 z i n i i -<

1 c 1 3 J i M 1 z i m

1 T l i m i n i m i t o <n

tr >— ' n s

- 0

t-t H 3 0 T J rtC Q r ri

-
r rr 0 f 3 O i c o a
>— • o a 0 i OLl O & 0 4 3 r-, n Z 0 «-• • 3 n r + T(T J 0 3

" l O fir ~\ o > >-• - 3 J U i

_ i T D f • a s n T1 0 OiC l 0 ) T

• < Q l ' 3 i n
- f i o T
z S U >- • fT j i n aP.2 6

Tabl e 1 0

. Orga n Lea d Concentratio n fo r Male s a s a Functio n o f Age
.

Inpu t t o Bloo d 3 0 u g pe r day

.

AG E BLOO D ug/m l BON E uq/ g as h LIVE R ug/ g KIDNE Y ug/ g

1 2
4 5 6 7 8 9 1 0 1 1 1 2 1 3 1 4 1 5 1 6 1 7 I B 1 9 2 0 0.08 9

0

. 12 1 0

. 11 0 0

. 10 5 0

. 10 9 0

. 10 4 0.09 8 0.07 4 0.06 9 0.07 8 0

. 10 5 0.09 9 0.08 4 0.07 5 0.08 5 0.08 0 0.07 8 0.07 B 0.07 9 0.08 1 26.6 1

28.5 9 31.9 6 •J>\J « O I 38.2 2 40.6 6 43.4 1 43.9 2 44.0 5 43.1 7 40.3 4 37.2 2 34

. 6 5 32.3 8 31.2 5 30.4 9 30.0 8 30.0 4 30.9 9 32.4 4 0.0 8 0

. 1 7 0

. 1 5 0

. 1 4 0.2 5 0.3 6 0.4 8 0.3 6 0.3 4 0.3 8 0.5 2 0.4 8 0.4 1 0.3 7 0.4 7 0.4 4 0.4 4 0.4 3 0.4 3 0.4 3 0.5 4

0.7 7 0.6 8 0.6 6 0.6 9 0.6 4 0.6 2 0.4 7 0.4 4 0.4 9 0.6 7 0.6 2 0.5 2 0.4 8 0.5 3 0.5 1 0.5 0 0.4 9 0.4 9 0.4 9O*0 C Ov l t hc nJ i 0 1 t o **•

O-43 CDv l t hU l J » 0 4 t o 1 3 > i t n i m ta

t r

u i c nu i u i c nc nJ i j s j i j i t o t o t o t o t o t o t o ^ » - •- » Ov l t hc nJ i t o t o •-

* J s f l - 0 0 4 OJt hu i O Jo o o o o • ^ v OChOJOt h0 4 U l t o t-

0 t- 1 0 0 Ov l U I t-

0 v l ChJ i J i «43UICDCDCnOOCDvlvlvl>OOJ>OOIMOtOfOc n j i c nu i J * o

j i v i o t hO Jo v i j i t o v i t-- c nc o J * ^

t- 0 » - ** O-4 ) -4 3 C Ov j v l t hC hU I J i J s 0 4 0 4 t Ot O•- t h- 0 t-0 U l C

O O 0 4 v l to v l t o 0 4 v l o c nO UI O U

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• C h• * *•* O O 0 4 vl C

O v l t h> 0 C n0 4 U I * 0 vl C O 0 4 vl t> c

n0 4 C O t O Ji 1 0 vl J

» O C O c o to o »- • ©

v l > 0 -f l M ) Cf ) ffl G

* t hC ht hJi 0 1 0 4 0 4 t-

j ^ C O C h£ 1 - <0 vl £ & Ji 0 4 t-

0 J s O J< Js t> C O CS v j t o I C D

t O 1 0 »» * * 0 *« 4 *iE D 1
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1 0 1 0 1 a

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o v o o o C D C D c o cn c n t h c n J i o i o i 0

4 C h 0 4 M *- ** 0 4 0 4 »-* • - 0 v l Cf

l t- 0 C D v l *- •& O t- 0 * - v l t

h- C O < ! C

D C O 1- * M t- 0 1 - O 0 0 C

hJs t- 0 C D C- 4 - O C O O t O f O t hU l 0 4 J * I T l i r n i n i m i c n n

s i nTabl e 1 2

. Orga n Lea d Concentratio n fo r Male s a s a Functio n o f Age
. Inpu t t o Bloo d 4 0 u g pe r day

.

AG E BLOO D ug/m l BON E ug/ g as h LIVE R ug/ g KIDNE Y uq/ g

1 2 o 4 5 6 7 8 9 1 0 1 1 1 2 1 3 1 4 1 5 1 6 1 7 1 8 1 9 2 0 • 0.11 9

0

. 16 2 0

. 14 6 0

. 14 0 0

. 14 5 0

. 13 8 0

. 13 0 0.09 9 0.09 3 0

. 10 4 0

. 14 0 0

. 13 3 0

. Il l 0

. 10 0 0

. 11 3 0

. 10 7 0

. 10 4 0

. 10 3 0

. 10 5 0

. 10 8 35.4 8

38

. 1 1 42.6 1 47.0 9 50.9 6 54.2 2 57.8 8 58.5 6 58.7 4 57.5 6 53.7 9 49.6 3 46.2 0 43

. 1 7 41.6 7 40.6 5 40.1 1 40.0 5 "41.3 3 43.2 6 0.1 0 0.2 2 0

. 2 0 0

. 1 9 0.3 4 0.4 9 0.6 4 0.4 8 0.4 5 0.5 0 0.6 9 0.6 4 0.5 4 0.4 9 0.6 3 0.5 9 0.5 8 0.5 8 0.5 8 0.5 B 0.7 2

1.0 2 0.9 1 0.8 8 0.9 2 0.8 6 0.8 3 0.6 2 0.5 9 0.6 5 0.8 9 0.83 " 0.7 0 0.6 4 0.7 1 0.6 7 0.6 6 0.6 6 0.6 6 0.6 6

### O- 0 0 0 v l C htf l J i 0 1 t- 0 i
- OO0 0 v l t hc nJ i OJt o» - I 3 > I 0 J i r n H

ill 

### c r f D
0 4 

### vi v i v i t ht > t htf l c nc nc nO J

### t o to O J

### c-

4 to to t o t o •- • 0 4 to o - o v j c

nt o » - c nj i t h>o co o t **• 

### - o c nJ > 

### c- 4 c- 4

- OJ s O Dt otf

l 0 0 OO0 4 OJ

> v l 0 0 ^ . >o o o

o c no o

- o j i c no t t > u i co c hj i o c o c no c o to t o c o O J

### t o c h 0 4 j i o- 

### o 0 4 j s o i c-

4 c n• - v i - o c n< j t o t ht o c no ot

Ul -t » J i Ol M » - O -0 - O O Dvl C hc nUl Ji O i C- 4 M^ M v l O O • - t-

0 0 4 Ji v l O Js vl v

l > 0 O 0 4 v

l t-- (J\ O H C D0 4 vl C Dv l J s » - 0 4 0 4 • - vl J s 0 4 C DO C O C O O C- 4 < ! 

### c- 4 o o w c nv i c nJ i - o v i o t o v i c no i o * vi • - » - > - a s J i c n>0 

### C DOv l >- • C Ov l OO» - U

l v j o t o U i t o J i ts

t- 0 t O • - H * >~-

O v l v ) CDv j U l J i J s J J0 4 tO » - »-• • h ) Q vl Js 1 0 - 0 v l cn. O C D0 4 0 4 *- * O DJ i O O O -4

3 0 4 CD1 0 C h- O • - 0 4 tO CDv l C

D• * 0 4 <l v j O 1 0 t

hO J i J i -t hCDJ s 0 4 th»

- O Oh 0 -Cv

l OD O C O - O >-t 0 v

l Cfl C h

t Ot OM t-0 t Ot O»- * ~»- • *

- i ^ »-»i- * J i J s 0 4 0 1 t O t~-

v l v l CDO

DI O - 0 * 0 H * O - 0 C

O 0 0 v l J s thf * thO C

n- DthC-4 J i O «-• • OU l • - fr fr fr »- * C h0 4 U I 0 4 O C

hO 0 4 U l H * 0 4 » - J i H » - 0 J i t- 0 0 > ^ " tht

h0 4

V H H H K K ) K H V M H H I-

1 U H H H H K H 

### t o t o t o t o •• * to 0 0 0 3 > o c

o c nOO 

### 0 4 t o t o <i 

### O Dv l o CDU l t O O v l CD0 1 O *•• vl t O C hv l tO » - 0 4 - 0 - 0 v

l O t o c no o o * - w c h» - o o c n- o O Jv i t-

O Jc nO JOJ>O -

•- * I - » ^ O O O v l v l v l v l cnJ i 0 4 J> 0 0 J s t o t o W J s t h0 1 » - O DC

h0 4 0 4 i- * t hJ i O H * < ) ChW

O U l J i I O C D J i - O J i O M

U l M 0 0 C nvl J i •- » 0 0 tO v l O CDJ

> < 3 O 1 C O

i r 1 o 1 o i a

1 C O 1 o 1 z i m

i r i t-t i < i m 1 3 J

1 X 1 H H 1 O 1 Z i m i - <

1 c 1 3 3 1 *- 1 z i m

i i i i m 1 n i m l- H

3 H T ) 0 C r r r rfli t-m rf o r n s C D Q
•- • a u o o a -. = a c n ta O 3 z Cl

••*• 0 n 3 Trf a I D " i D D Tr r Oi
^ 3 I-.

. U i 3 T J Z r o H Tn -\ O 0 Q J i O

- < T

• 0 > a in

-r » 0 T
T B » >- < r o m a

I U JP.3 0

Tabl e 1 4

. Orga n Lea d Concentratio n fo r Male s a s a Functio n o f Age
.

Inpu t t o Bloo d 5 0 u g pe r day

.

AG E BLOO D ug/m l BON E ug/ g as h LIVE R ug/ g KIDNE Y ug/ g

1 2
4 5 6 7 8 9 1 0 1 1 1 2 1 3 1 4 1 5 1 6 1 7 1 8 1 9 2 0 0

. 14 8

0.20 2 0

. 18 3 0.17 5 0.18 1 0

. 17 3 0.16 3 0.12 4 0.11 6 0.13 0 0.17 5 0

. 16 6 0

. 13 9 0.12 5 0.14 1 0

. 13 4 0.13 0 0.12 9 0

. 13 2 0

. 13 5 4 4 - 3 5

47.6 4
en * o L. 58.8 6 63.6 9 67

. 7 7 72.3 4 73.2 0 73.4 2 71.9 6 67.2 3 62.0 4 57.7 5 53.9 7 52.0 8 50.8 1 50.1 4 50.0 7 51.6 6 54.0 7 0

. 1 3 0.2 8 0.2 5 0.2 4 0.4 2 0.6 1 0.8 0 0.6 0 0.5 7 0.6 3 0.8 6 0.8 0 0.6 8 0.6 1 0.7 8 0.7 4 0.7 3 0.7 2 0.7 2 0.7 2 0.9 0

• 1.2 8 1

. 1 3 1.1 0 1

. 1 5 1.0 7 1.0 3 0.7 8 0.7 3 0.8 1 1.1 1 1.0 4 0.8 7 0.7 9 0.8 9 0.8 4 0.8 3 0.8 2 0.8 2 0.8 2O ^ CDv l t hcnJ i 0 4 t o » - O - O 0 0 v l thU l J i 0 1 1 0 • -

OD0 0 CD0 0 CDv l thC

ht ht hJ i 0 4 C-4 J i 0 1 O l C- 4 M

t O» - C DC hU l 0 4 »- * -t ) 0 4 t-0 t hJ i O JU l J i O C DJ s •- * > 0 v l c n v l < 1 O O O O U I O JJ i - 0 v j v l U l ^ C- 4 O DOJ > C ht h *0 0 4 t- 0 v l v l t o O Dc

n*-• O C O• - th0 0 O C-

4 U I -l i 0 4 v l to to v j o - C

hc no u i j i - o Ji •-

* c hv i o - *-* co t o ui o 0 0 v l t htf

l J i 0 4 1 0 » - o O >

0 C Dv j ( hc nJ i 0 4 0 4 t O>-

- 0 ^ 0 C DC Ov l t hJi fr O DO O JO *-•

•- * t o c n0 0 » - O JJ > J i t- 0 O DtO0 4 H * > 0 CDJi O 0 1 -O t OO v i J s t - O » - 0 4 o t hvi oi to j i vi vi c

nc nJi fr io o c nj s vi - o v j m t ^ 0 4 J i OJi 0 3 Ov l 0 4 t

ho o ui c nJi W v l C DJi vl c n

J s 4 s J s 0 4 0 1 0 4 - O -0 -0 -4 3 C hU l U I C

n J i t O » - >-

* ^ v l J s H * v j J s K-

- 1 0 O C h - > 0 1 1 0 O O

Q O Js t- 0 M ^ 4 » J i 0 4 *•* • - o cnH * v l < 1 O

Dth0 0 O 0 4 cnv l I O v i o 0 4 n J i J i v l t O« 0 v j tfl th.v l 0-_ O C h0D.Ji_ O UlUI-OO-J i t h 1 3 > 1 G J i m

1 C D i r 1 o 1 o 1 C J

1 CO 1 o 1 z i m

i r 1 H

. i < i m 1-31 - - H

J U cr t—• ra

H * c n

. l- H 3 H
• D 0 C r + r + fli t— • r + o r f O C O fli » - a 0 0 o a n i O fr Ql o n zn *- •o n 3 Tno ra 0D- 3 n r r £ U 3 »- . U i 3 f- 0 t- 0 M I O M MMHMNHr.HHHH H -O0D00vlvlth>-'OW^JiH'i-O4t0^O»0-t)C n U l - O O l t h O C-

4 >- v j i- ^ 0 - tf l 0 0 U l 0 4 v l Cf l 04 v l t-

fO v | c n t o v | o t

o C O v l W t-

0 v l < | w v l c

n « 0 0 4 « 0 - 0 o

HMKHHMHHM M 04 t O 1 0 t- 0 I O t- 0 t O t O t- 0 i- * t f l Cf l J i J s J i v l t- 0 • * 0 4 t- 0 O J s O J v l t h C h O J 1 0 • - t O O J O v 4 J i O 04 O C

h O U I 0 1 v l -4

3 C O U l 0 0 O C h t- 0 O •4 3 fr 0 4 O C n - 0 J i •- » f j O U l tf l t h t h U l 0 4 t- 0 O D C O v l I X

I w I O I Z i m i - <

i c I 3 J Il- H i z I H i T

J Z ra H

i n
" i o o fli l O < 1

• £ U 3 U l

. -r . 0 T z fl)

04 0 4 0 4 04 I O t O C

D C O - 0 C D C h - > J » U l -4

3 U I 0 4 t- 0 1 0 U I -0th04Ovjjsvlth»-'OO-Dvlcn-43CDO-0vlv | v j v | v j v l U I O

J < 1 h ) C

O v l J i O

J v j c n t o C

D - O 0 4 c n t h I T l

i m i n i m i c n ra

mP.3 2

Tabl e 1 6

. Orga n Lea d Concentratio n fo r Male s a s a Functio n o f Age
.

Inpu t t o Bloo d 6 0 u g pe r day

.

AG E BLOO D ug/m l BON E ug/ g as h LIVE R ug/ g KIDNE Y ug/ g

1

*^ l 3 4 5 6 7 8 9 1 0 1 1 1 2 1 3 1 4 1 5 1 6 1 7 I B 1 9 2 0 0

. 17 8

0.24 2 0.22 0 0.21 0 0.21 8 0.20 7 0

. 19 5 0.14 9 0

. 13 9 0

. 15 6 0.21 0 0

. 19 9 0.16 7 0

. 15 0 0

. 17 0 0

. 16 0 0

. 15 6 0

. 15 5 0

. 15 8 0

. 16 1 53.2 2

57

. 1 7 63.9 2 70.6 3 76.4 3 81.3 3 86.8 1 87.8 4 88

. 1 1 8 6

. C<> J 80

. 6 B 74.4 5 69.3 0 64.7 6 62.5 0 60.9 7 60.1 7

. 60.0 8 61.9 9 64.8 9 0

. 1 5 0.3 3 0.3 0 0.2 9 0.5 1 0.7 3 0.9 6 0.7 2 0.6 8 0.7 5 1.0 3 0.9 7 0.8 1 0.7 4 0.9 4 0.8 9 0.8 7 0.8 7 0.8 7 0.8 7 1.0 8 4 er-: r 1

. o o 1.3 6 1.3 2 1.3 8 1.2 9 1.2 4 0.9 4 0

. 8 8 0.9 7 1

. O O 1.2 5 1.0 5 0.9 5 1.0 7 1.0 1 0.9 9 0.9 8 0.9 8 0.9 9O- O C Dv l fr tf l J i 0 4 h ) »-

» O -4 3 0 0 v j ChU l J> 0 4 t O H * I T> I Q I m - I

O i t r i- " ts

O O -4 3 - 0 - 0 < ) v l v | v l v l Cf l J s J s J s J s J s 0

4 0 4 0 4 •- * 0 4 ^ - 0 C

h J i t- 0 J i tO v l cn **

• * O t h J i O t h J s tO C O U l J s »- » - 0 tf l ^ •- •v l J i v j O t h 04 0 0 C h C h 1 0 0 1 1 0 1 0 -OtO-43IOCO-OvljsCDt-OCOChtOCD-00 4 0lJiJiO O O • - - 0 • - C

O t h v | C

O 0 1 v l 1 0 0 1 v l U l O v l * - 0 •- •- 0

1 0 O -4 3 CDv l cnJ i 0 1 t o » - O - 0 COv l C hc nJ i 0 4 M

f 0-Ov|Js^COUlthChvl00^.01i-»-04JiO-vlt h

- 0 • - O C

hC DCOv l 0 1 U I v j - 0 J i O •- » U l O U l t-

0 O v l C hJ s t- 0 O v l 0 4 -4

3 C nW O DO Ch- 0 v l * » M

J i v l J s C

D C OO O t- 0 v j O CO v l 0 0 0 4 C

hO t ht O J i * - >-

v l O 0 4

vithththcncnoo^^vichuio^Jit-o^t-' ^ t OC OJ i O v j 0 4 C

O0 - 0 4 O J

i O C OC Dv l C OJ i J s 0 1 J s O Ji v l - 0 O O t-

0 » - O Ji Ji v j v

l t o v l t o C O^ t o C O • * O O O t

O0 4 *-M O •-•

• J » Ji Ji O D- 0 t- 0 -4 3 v l o 0 4 U l

0 1 0 1 0 4 0 4 0 4 O l t-0 t Of Ot O•" * »- * »-* i-

» •* • ~*- *- -*

- > 0 4 0 4 1 0 >-

* O J i J s U I c nv l 0 4 0 4 U I J i C- 4 t- 0 • - O fr c nv l O t O U I v l v l t o C Dt- 0 OC DJ i t hCOU l O J i v j O OC DJ i COO O *•

* 0 1 »- * t- 0 O v l C-4 O v l t OC h0 4 t Ov j

',-* H » f- +* t-m 0 1 tO t O t-

0 t O 04 t- 0 t- 0 0 4 0 4 0 4 t- 0 f O 1 0 H * vlv|vl(hChi-'UlCnChChUlCDvltOO^vlo-JiJ i -4 3 U l • - CO0 1 - 0 v | 1 0 ODI OJ i C D- 0 U l - 0 O J- 0 J . COO u i v i - o o - o c n>- * i
- u i c n**• c o c no c o o •-* • c nC- JO

c hU I U I c n-t s J S o o o o v j c

nc no - I- * c hO I 0 4 011 > 1 0 - 0 C hf- 0 ODU l t- 0 O v l J s O v l U l J i U I COChJ i W v l v l c nQ J s v l o u i cn» - t htf l UI v l v l C DC h• - W i- ' w 1 t o

i r 1 o 1 o i a

1 C O 1 o 1 z i m

i r i •- « i < i m 1 3 )

1 X 1 n i a 1 z I m i <

1 c 1 3 3 1 l- t 1 z i m

1 - n i m i n i m l- H

3 -\ T J 0 C rf rf flj i- » r+ o r C O tu *-• a 0 0 o a T J 3 v j S> O 3 Z C O H - 0 n 3 ~, rf o ra i D a T.- + J U 3 >- • Ul D T J Z ra i- 1

- Tn T O 0 fli >a < - •JU 3 m

- h 0 T

_ £ J U i - * M S i n B
C DTabl e 1 8

. Orga n Lea d Concentratio n fo r Male s a s a Functio n o f Age
. Inpu t t o Bloo d 7 0 u g pe r day

.

AG E BLOO D ug/m l BON E ug/ g as h LIVE R ug/ g KIDNE Y ug/ g

1 2 3 4 5 6 7 8 9 1 0 1 1 1 2 1 3 14 1 5 1 6 1 7 1 8 1 9 2 0 0.20 8

0.28 3 0.25 6 0.24 5 0.25 4 0.24 2 0.22 8 0.17 4 0

. 16 2 0

. 18 2 0.24 5 0.23 2 0

. 19 5 0

. 17 5 0

. 19 8 0

. 18 7 0

. 18 3 0

. 18 1 0

. 18 4 0

. 18 8 62

. 1 0

66.7 0 74.5 7 82.4 0 89

. 1 7 94.8 8 101.2 8 102.4 9 102.7 9 100.7 4 94

. 1 2 86.8 6 80.8 5 75.5 5 " 72.9 2 71

. 1 3 70.2 0 70.0 9 72.3 2 75.7 0 0

. 1 8 0.3 9 0.3 5 0.3 4 0.5 9 0.8 5 1

. 1 2 0.8 4 0.7 9 0.8 8 1.2 0 1.1 3 0.9 5 0.8 6 1

. 1 0 1.0 4 1.0 2 1.0 1 1.0 1 1.0 1 1.2 6

1.7 9 1.5 9 1.5 5 1.6 1 1.5 0 1.4 4 1.0 9 1.0 3 1

. 1 3 1.5 6 1.4 6 1 o o 1

. 1 1 1.2 5 1

. 1 8 1

. 1 6 1

. 1 5 1

. 1 5 1.1 5O- 0 CDv j t hcnJ i 0 4 t-

0 • - O -4

3 COv l thcnJ > 0 4 t-

0 i- *

H * ^

_» ^ OOCOCOO Dt DU l ^ > J i U l U I J i J i 0 4 04 ' t- 0 COC n0 4 O COU I J i 0 4 C

OC hCDv j th0 4 >-«

• t h* - - 0 thO 0 4 - O0 4 v l *-

0 1 v l i
- tf

l U l 0 4 0 - O U l O J

» - & t- 0 CD- 0 C0»-vl(hOthv!4sUIJivl^C0C0vlJi»-UlJi O

- O O O v l ••* v j 0 1 O 1 0 t h - 0 U l 00 0 4 U I t- 0 " ^ C h v l t o

I Ot- 0 t- 0 M *- • - H« . t--

f- » - H » tcn0 1 t o > - -4

3 C Dt hc nJ i 0 4 M O - 0 COv l thU I ^ > 0 4 » - f0-0UlOCh>-thUlJiJiJivlJiH-OOO»-*O- 0 u i o »- • - DJ i c nChCOththJ i - 0 - 0 0 4 0 4 cn- 0 J i - 0 i
0 4 H * C hv l 0 4 O Jt- 0 O JO O t hc nC h0 4 0 4 - 0 O U l O OD JivlChJ>*-*i-'thvlJi-0JiJsvi<JthChJi-0O4C =

- 0 - 0 C OO Dv l v l t OM

t- 0 t OC Df ht hv

l U l 0 1 •- » •- * • - t hW 0 0 0 4 -43 -t

> 0 4 H * - 0 t

hC n- 0 v l 0 0 J i W

v l C hU l U I tf l J i 1 0 C DJ» - 0 t ht o • - M O Ji » - o c

n0 4 O » - » - U

l C DU I 0 4 - DU l O v l 0 0 C

ht- 0 v l »-• CDU 1 J i 0 4 O »-

» 1 0 ^ >

0 4 0 4 0 4 0

4 UUM M W M H H H KH H P H H

- 0 0 0 v l Cht

hU I CDv l - 0 C D- 0 U I U I v j v l cn0 4 0 4 t Oth -fc » Chv l 0 0 O O t

OC hJi 0 0 Ji 0 0 0 4 0 0 O J

> v l O t- 0 - 0 0 4 H ' 0 - -0 O - 0 J i -

D - 0 1 0 0 4 U I J i 0 4 O U I 0 3 C hU l J i

M M t-- t-. M - o\ M W 0 4 I OJ» 0 4 0 4 0 4 0 4 0 4 0 4 0 4 M • - OO>0-0C00--43CDO-0OO4«-*vlCflCn»-'OC0t h U l OC h»- » v j cn0 1 0 0 0 - - 0 J» O-4 3 >- . J i v i 0 0 1 0 0 4 »-

» t o - o cn- 0 0 1 t o OD*-

• - D- 0 v j o cnJ» Ov l - D0 4 G Oo

C00DvJvlvlth»-*-*h3H»CDo-Chv|OJv|JiO4O4v l t > t O O D J i O U l v l J i t-

0 - 0 O U

J 0 4 C- 4 1 0 0 0 *- * - 0 C

h t h tO C- 4 04 WO v l ^ - O J i t h t h 0 0 C h - 0 04 J i W^ v l C D I 3> I C J i m

i r i >-* i < i m I 3 J

i x I H H i a i z i m i -<

t r 3 J l- H z m

I T l i m I C O i m i co H

JU c r t—r ra
i- * -4J
1 CO i r 1 o 1 o i a

1 CO i a 1 z i rn i- <

3 H T > 0 C r r 1 + Q | i— • t + o r n s C O fli !- •a 0 0 • a i 0 3 O D fl; O 3

•* •0 n 3 i 0 t a T 01 3 U l ra 3 rf

>-•• 3 T J Z raw - -\ n O 0 fli i Q

- < T
•0 ) 3 U l
o
Z J U l - « ra i nTabl e 2 0

. Orga n Lea d Concentratio n fo r Male s a s a Functio n o f Age , Inpu t t o Bloo d 8 0 u g pe r day

.

AG E BLOO D ug/m l BON E ug/ g as h LIVE R ug/ g KIDNE Y ug/ g

1 2 3 4 5 6 7 8 9 1 0 1 1 1 2 1 3 1 4 1 5 1 6 1 7 1 8 1 9 2 0 0.23 8

0.32 3 0.29 3 0.28 0 0.29 0 0.27 6 0.26 0 0.19 9 0.18 5 0.20 8 0.28 0 0.26 5 0.22 3 0.20 0 0.22 6 0.21 4 0.20 9 0.20 7 0.21 1 0.21 5 70.9 7

76.2 3 85.2 2 94

. 1 7 101.9 1 108.4 3 115.7 5 117.1 3 117.4 8 115.1 3 107.5 7 99.2 6 92.4 0 86.3 5 83.3 3 81.3 0

• 80.2 3 80.1 1 82.6 5 86.5 2 0.2 0 0.4 4 0.3 9 0.3 8 0.6 8 0.9 7

X • ii

1 O 0.9 6 0.9 1 1.0 0 1.3 7 1.2 9 1.0 8 0.9 8 1.2 5 1.1 9 1

. 1 6 1

. 1 5 1

. 1 6 1

. 1 6 1.4 4

2.0 4 1.8 1 1.7 7 1.8 4 1.7 2 1.6 5 1.2 5 1.1 7 1.3 0 1.7 8 1.6 7 1.4 0 1.2 7 1.4 3 1.3 5 1.3 2 1.3 1 1.3 1 1.3 10 - D C D v l C h C Q J i 0 1 M •- * O - 0 C O v i 0 - U l J i 0 1 t O i- 1

••* •> • * fr iJt H" * H - •1 ^ O J c-i t o t o to i

- - o -o -o -o t> c n c n o- c n c n J i j i J i to 0 1 O v l J » f-- C

D U I O l - 0 v l U l O

J i - O v i I O t h J s t - O l
•- * c- 4 u i t h t h c

n c-i c n t> 0 4 o - c n c o t o J i t o cn»-»- > c

n C D -0 J > •- » • * 0 4 v l 0 4 1 0 t h v l t h J i 0

0 U l J i C O 0

- U I » - v l - 0 i- » O

J 0 4 C D O 04 • * - > t > v i - 0 • - - 0 v i v l 0 1 0 4 J >

t o t o t o t o to t o » - » - *-

* • - *-• M

. ^ C D t h c n 0 4 to O C O v i C h U I J i to O - 0 v i C

h c n J i 0 4 to J i C O 0 4 v l O J i v l c

n t o • - O •-

* C h • - -f l 0 0 v l C h J i i

- »- * C O 0 1 0 4 -4 3 W J i 0 4 C h J s O J i C O c n • * » - W C

h v l c n O - 0 • * *>

C D t- 0 C n *~v l 0

4 t O J i 04 O tO v i C

h J i C h v i » - J i t o U l U l I O U I C h -4 3 c n t o C

O C D f h C O O v l f-

fr O J

t- 0 MIOHHHHKH H t- 0 H * *-* O O - 0 04 0

4 J i J i - 0 v l v l 0 0 fr 0 4 ••* >- >- * vfhi-*Ch>-Ch-OChUlt0UIC0CnvIi-»O^-OC0vlC h

•- * U l v l C

D C O v i i - J i 0 1 O v l O U l C O 0 4 0 4 H » »- * O 1 0 t > H - U I C

D C D f h 04 J i O O O - 0 v j t - U l v l S 3 1 0 » - 0 1

1

•J s J s J i J s J s 0 1 0 4 0 4 0 4 WMHKMHHHK K J i 0 1 t O » - O -f l • - • - 0 4 tO »•* •v l v i O - 0 v i U l J i 0 1 v j • O J j s j i c n c n j s v i f f " j s o

o c o to o •" * o i u i t h v i c

o C h 04 C D O O v l v l U l 00 04 C h O J t h C h 1 0 00 O - 0 C

D O

> 0 t- 0 t O t- 0 t- 0 J s 04 0

4 0 4 C- 4 J » O J O J J s 04 J s 0

4 04 04 •- • O J to to f- 1-» t-

O J i o J > O

J c n v i c n »- * -o o c n J » >- c o ooi-'cnooojiUiviuii--flvioorocDo-GH * C D O O - 0 v l C

O U l t- 0 0 1 J i t O O

J J i C D O J J * C D H - 0 4 H *

t0 t O 1 0 »-*

•»-* •t- ' »-* •H * *-- t-- V- 1 O O O - 0 -4

3 O D C- 1 t O O J O J - 0 v j v l 00 J s C

D J i J i J i C

O -4 3 U l O t h »-

* f h i1 -f l v l J s O J s » ^ 04 C D C O C h J s ^ t h c n • - t h o r-

o j s c o wo- c n vj Q c h wc o t o J i o o i j sAGEBLOODBONELIVERKIDNEYURINEFECES"'Table21.TotalLeadOrganContentin;MicrogramsforMales.InputtoBlood90MicrogramsperDay. 4Tabl e 2 2

. Orga n Lea d Concentratio n fo r Male s a s a Functio n o f Age
. Inpu t t o Bloo d 9 0 ug pe r day

.

AG E BLOO D ug/m l BON E ug/ g as h LIVE R ug/ g KIDNE Y ug/ g

1 2 3 4 5 6 7 8 9 1 0 1 1 1 2 1 3 1 4 1 5 1 6 1 7 1 8 1 9 2 0 0.26 7

0.36 4 0.33 0 0.31 5 0.32 7 0.31 1 0.29 3 0.22 3 0.20 8 0.23 4 0.31 5 0.29 8 0.25 1 0.22 5 0.25 4 0.24 0 0.23 5 0.23 3 0.23 7 0.24 2 79.8 4

85.7 6 95.8 7 105.9 4 114.6 5 121.9 9 130.2 2 131.7 7 132.1 6 129.5 2 121.0 2 111.6 7 103.9 5 97.1 4 93.7 5 91.4 6 90.2 5

. 90

. 1 2 92.9 8 97.3 3 0.2 3 0.5 0 0.4 4 0.4 3 0.7 6 1.0 9 1.4 3 1.0 B 1.0 2 1

. 1 3 1.5 5 1.4 5 1.2 2 1

. 1 1 1.4 1 1.3 3 1.3 1 1.3 0 1.3 0 1.3 0 1.6 3

2.3 0 2.0 4 1.9 9 2.0 7 1.9 3 1.B 6 1.4 0 1.3 2 1.4 6 2.0 0 1.8 7 1.5 7 1.4 3 1.6 0 1.5 2 1.4 9 1.4 7 1.4 8 1.4 8,-s-mr f r P.3 9

Tabl e 2 3

. Tota l Lea d Orga n Conten t i n Microgram s fo r Males

.

Inpu t t o Bloo d 10 0 Microgram s pe r Day
.

AG E BLOO D BON E LIVE R

~ 1 2 3 4 5 6 7 8 9 1 0 1 1 1 2 1 3 1 4 1 5 1 6 1 7 1 8 1 9 2 0 261.2 7

460.5 9 490.7 0 517.6 4 580.5 2 638.4 3 669.7 9 576.1 0 595.1 9 729.7 4 1081.8 2 1106.9 0 1039.2 6 1059.6 7 1317.0 9 1351.2 6 1384.5 9 1417.1 3 1448.8 7 1479.8 6 2397 5

3862 8 5182 4 6363 0 7574 5 8792 0 10167 4 11870 9 13494 2 15558 0 16826 1 18075 5 19479 6 20828 3 22691 4 24553 9 26371 7 28145 7 29877 1 31566 8 69. 3

189. 0 201. 4 212. 5 404

. 1 681. 7 975. 6 839. 7 867. 7 1063. 4 1577. 7 1614. 5 1516. 0 1545. B 2186. 2 2243.1

. 2298. 6 2352. 8 2405. 7 2457. 3 KIDNE Y

86. 7 153

. 1 163. 2 172. 2 193. 2 212. 4 222. 9 191. 8 198. 2 242. 9 360. 3 368. 7 346. 2 353. 0 438. 6 450. 0 461. 1 472. 0 482. 6 492. 9 URIN E

20

. 1 2 35.4 7 37.7 9 39.8 7 44.7 1 44.2 5 46.4 3 39.9 3 41.2 6 50.5 8 37.4 9 38.3 6 36.0 2 36.7 3 45.6 5 23.4 2 23.9 9 24.5 6 25

. 1 1 25.6 4 FECE S

9

. 6 0 4.5 9 4.8 9 5

. 1 5 9.8 0 16.54 9.2 4 7.9 5 8.2 2 10.0 7 14.9 5 15.2 9 14.3 6 14.6 4 20.7 1 21.2 5 21.7 8 22.2 9 22.7 9 23.2 8Tabl e 2 4

. Orga n Lea d Concentratio n fo r Male s a s a Functio n o f Age
. Inpu t t o Bloo d 10 0 u g pe r day

.

AG E BLOO D ug/m l BON E ug/ g as h LIVE R ug/ g KIDNE Y ug/ g

1 2
4 5 6 7 8 9 1 0 1 1 1 2 1 3 1 4 1 5 1 6 1 7 1 8 1 9 2 0 0.29 7

0.40 4 0.36 6 0.35 0 0.36 3 0.34 5 0.32 5 0.24 B 0.23 2 0.26 0 0.35 0 0.33 1 0.27 9 0.25 1 0.28 3 0.26 7 0.26 1 0.25 9 0.26 3 0.26 9 88.7 1

95.2 8 106.5 3 117.7 2 127.3 9 135.5 4 144.6 9 146.4 1 146.8 5 143.9 1 134.4 6 124.0 8 115.5 0 107.9 3 104.1 7 101.6 2 100.2 8 100.1 3 103.3 1 108.15 0.2 5 0.5 6 0.4 9 0.4 8 0.8 5 1.2 2 1.5 9 1.2 0 1

. 1 3 1.2 5 1.7 2 1.6 1 1.3 5 1.2 3 1.5 7 1.4 8 1.4 5 1.4 4 1.4 4 1.4 5 1.8 1

2.5 5 2.2 7 2.2 1 2.3 0 2

. 1 5 2.0 6 1.5 6 1

. 4 7 1.6 2 2.2 2 2.0 8 1.7 5 1.5 9 1.7 8 1.6 9 1.6 5 1.6 4 1.6 4 1.6 4• O - 0 C O v l t h U I J i 0

4 t- 0 i " O - 0 C

O v l t h c

n J i 0 4 t o • -

t > c n c n u i J i j i ^ i - t o i - o o o- t h v i v i t h u i u i c n t o t- 0 -f l U l t-

0 C O J i 0 - J i H * - o o c

n 0 4 0 4 O C- 4 0 - f l O 0

0 v l 0 4 C D 0 4 C h C D U l 0 4 v l O t O J i 0 4 t h t- 0 0 0 -f l - 0 C

h v i C O v l C D O 0 1 C

D C h » - 0 ^ O v l v l v l v l tO c n J i v j t h J i U I t h J i cn C

O O 0 1 O

D O O • - O i " v l C

D v i O v j c n o

Jit0O-flv!JstOi-*-43C0v4JsO4^-flC0ChtnJit 0 v i C O - 0 O O - 0 - 0 J i o

o c n **• C O O » - C

h C- 4 - 0 v i r- 0 0 - t- 0 C h t h O O t h ^ t

O C D O • - J i U I 0

0 v i 0 4 -f l O J i 0

4 04 J s O O

D -f l O » - v l 0

4 00 0 1 04 C

O J s ^ t - -f l O - 0 v i U l C D C- 4 - 0 0 4 Cf l •• » C n O v i 00 v i O i - 1 0 - 0 C- 4 fr * - 0 1

t o t o t o t o t o t o »-

• • - • * •- » > - • - vlO^UICn->JiVlthvJvlv-*<|-flOvJjstOIO W O J i O D t- 0 t h O O t h v j WC h C n t- 0 v l J s J s O l h J O v l 0 4 fr C O C D v l J s O v i U l U l - 0 J s 04 0 4 - 0 J > 04 » - v l t h O 0 4 • * U I -l i 0

0 J i t h - 0 U l v l J i v i t o - o c n v l U l - o t o

1

• • u i c

n c n u i J i j i 0 1 0

4 J i O J t o t o t o t o t o t o »-

* • - *- Js0J»-'O-0tDC0C0O-0th»-'i-*-Js0jH'0DvlO-f l t o 0 - Av i u i t o 0

0 0 c n t h v i O

D i- 1 c n 0 1 t o -f l - AC

O c n 1 t o C D t o t o 0 c

n 0 4 c o c n 0 4 t o 0 0 t o v j c

n u i c n c n j s 1 1

t o t o t o h

o t o u i -t > 0 1 J i j i c

n j s J i tf l J i j s J i j s 0 1 t o 1 0 0 v i v i t h U l 0 0 - 0 t o • - u i c n 0 4 1 - O D -f l 0 4 H * -f l t o 1 1 0 C h O 0 4 v l i o J i f h t

O f O C h 0 4 - 0 O t h t - 0

0 U I O » - 1
• - f O *- * -f l C h * - O t O O J i J i O

D 0 4 v i C D 0 0 U l v l t O 0 4 I

t o t o t o 1 0 t o t-

0 *- * »- * • * •- * «•

* •- » H * • - ^ I cn tf l J i 0

4 0 4 t o t h cn C

h t h •- * - 0 C

O O C O O U l U l U l O 1
o - o c n - o c-

4 v j **• c o c o j i o o v i i

- • - v i c h o i o - c n i •"vltOtflviOO'-'OfOJsOO.JsUlvl-OajvlvlJsCh lAGEBLOODBONELIVERKIDNEYURINEFECESTable25.TotalLeadOrganContentinMicrogramsforMales.InputtoBlood110MicrogramsperDay.P.4 2

Tabl e 2 6

. Orga n Lea d Concentratio n fo r Male ;

Inpu t t o Bloo d 11 0 u g pe r day

. a s a Functio n o f Ag e

AG E BLOO D ug/m l BON E ug/ g as h LIVE R ug/ g KIDNE Y ug/ g

1 2 3 4 5 6 7 8 9 1 0 1 1 1 2 1 3 1 4 1 5 1 6 1 7 1 8 1 9 2 0 0.32 7

0.44 4 0.40 3 0.38 5 0.39 9 0.38 0 0.35 8 0.27 3 0.25 5 0.28 6 0.38 5 0.36 5 0.30 6 0.27 6 0.31 1 0.29 4 0.28 7 0.28 4 0.29 0 0.29 6 97.5 8

104.8 1 117.1 8 129.4 9 140.1 3 149.1 0 159.1 6 161.0 5 161.5 3 158.3 0 147.9 1 136.4 9 127.0 5 118.7 3 114.5 8 111.7 8 110.3 1 110.1 5 113.6 4 118.9 6 0.2 8 0.6 1 0.5 4 0.5 3 0.9 3 1.3 4 1.9 9

2.8 1

7 5 3 3

I J^s-l 3 8 8 9 7 7 ,4 9 3 5 1.7 3 1.6 3 1.6 0 1.5 9 1.5 9 1.5 9 2

.

2

. 4 9 4 3
2.3 6 2.2 7 1.7 2 6 1 7 8 4 5 2 9 9 2 1.7 5 1.9 6 1.8 5 1.8 2 8 0 8 1 1.8 1

### O- 0 C Dv j C hU l J i 0 4 t o • " O-f l 0 0 v i t hc nJi O I 

### t o » - I 3> I G J i m JU



### c r

v l v l v l t

h0 - U I K Jt- 0 0 4 t- 0 O Dv i fr O Dvj . f > C hU l U l 0 1 v i 0 4 O t > t-

0 O Dv l J s t- 0 - O v l i- . -f

l O f h- 0 1 0 0 0 U

l • - U l C DO H » »-

• O • * v j 0 0 C

O U l Ji » - O Jt ht h• - C O K ) O J 

### 0 0 o - c nu i c nU I C h•

- t- 0 H - t ht O0 4 v l t - C h»-* C Dv l c n 0 4 U I U l ~- i- 1 

### >- O~- - 0 o o -o t o t o c nIOOl C hJi *-• t-0
0 4 0 4 0 4 0 4 t

OM t OM M t- 0 •- • • - v i c n0 4 *-t -f l v i Js 0 1 • - O C

Dth C D0 0 v i fhJ i t O - 0 0 1 t ht- fr » - C Dc nv i J s t ht Ov

l v l - 0 -f l t h- 0 J s O Ul C D0 4 i
- 0 1 

### o t o J i t hj i - o oi c no H » 

### -o O J

### u

i o o - A U I O D

### c n t-0 Cf l -f l O v l C h- A c nC h0 4 t h•-* • »- * -f l O l J i C h- 0 Js J i 1 0 O -f

l V j fhJ i tO 

### t ot oc nOC ht OC hO D

v l v l 

### o

-flCOCDvlChChCOCO-OCOtOOOi-'CDJstOlOt O 

### j i o ot oc n-f

l t oc ni- ' c- i - ov j j s o vi«- » c ou i ^ . t oC D C O C hO JCD•- • o i cn-f

l v l O JC hi
- v l O 0 0 J s cni
- thO J
v l C O J i J i G DJ i O tO 0 4 O

JO t O v l 0 0 »-

* - 0 O v JC Di


### u i c nu i u i u i u i J i j i J i j i t ot ot ot o M N 

### t o• * •• * > -

- 0 vl C htf l J i 1 0 t O i-

* J i C- 4 -f l O l 0 4 t hU l 0 4 O - 0 C

DO *-* • - 0 t h0 4 O t h0 4 c nt o t o *-••

v l O v l J s H » thUl 0 4 Js Cn»-JiJi 0 04ChJsJs04CnCOt-OUI-43(33v!-flCO O

0 4 0 4 t-0 t Ot-J

U l J i J s J i J s C hJ s J s U I U l U I J i J i J i t-0 

### o o - o o o GO

### j s j i c- 4 f hj s o -f l v i c no i o i v j c nr o j i

v l H * J s v l t-t

v l O I O O - 0 v l U I - 0 v l i- » 0 - 0 0 0 4 U I H » 

### v i oi v j >o o c

o vi w c- j -o o f t

o i
- o c nJ i c nv i c n I w i r I o I o i a

I C O i a I z i m

i r I HH I < I m I 3 1

I M i a I z I m I <

I c I 3 ) I n I z i m t

o v l

3 H T J 0 C rf ff fl) I— « rf a r ra C O J U t-* a 0 

### o o ai tD >~t tjl t O 3 r-, " C O z o H- - 3 ff ra 3 rf n o
i O
J U 3 U l

- a H ran 1 T 0 D i Q J U T

• < J U

• 3 m 0 T z J U
I O t- 0 tO 1 0 1 0 K

J •-• •i- * •-•»- » i- * H » ^ i- ' •- •| T ] vJvlChChCnjivlvlCDvltO-0-Oi--43^thCncni- ' -f l o i v i i - c

n o o c n t o o i -f l o c

o u i o o o vi» - O

D c n c n c- i c n c n O J o c n v i c- i c n j i - o t h u i - o u i t h -f l o

- o t o i m i n i m IC D ra

U lTabl e 2 8

. Orga n Lea d Concentratio n far

Inpu t t o Bloo d 12 0 u g pe r day

. Male s a s a Functio n o f Age
.

AG E BLOO D ug/m l BON E ug/ g as h LIVE R ug/ g KIDNE Y ug/ g

1 2 3 4 5 6 7 8 9 1 0 1 1 1 2 1 3 1 4 1 5 1 6 1 7 1 8 1 9 2 0 0

. 35 6

0.48 5 0.43 9 0.42 0 0.43 5 0.41 4 0.39 0 0.29 8 0.27 8 0.31 2 0.42 0 0.39 8 0.33 4 0.30 1 0.33 9 0.32 0 0.31 3 0.31 0 0.31 6 0.32 3 106.4 5

114.3 4 127.83 141.2 6 152.8 7 162.6 5 173.6 3 175.6 9 176.2 2 172.6 9 161.3 6 148.9 0 138.6 0 129.5 2 125.0 0 121.9 5 120.3 4 120.1 6 123.9 8 129.7 7 0.3 1 0.6 7 0.5 9 0.5 8 1.0 2 1.4 6 1.9 1 1.4 5 1.3 6 1.5 0 2.0 6 1.9 3 1.6 2 1.4 7 1.B 8 1.7 8 1.7 4 1.7 3 1.7 3 1.7 3 2.1 7

3.0 6 2.7 2 2.6 5 2.7 6 2.5 8 2.4 8 1.8 7 1.7 6 1.9 4 2.6 7 2.5 0 2

. 1 0 1.9 1 2

. 1 4 2.0 2 1.9 8 1.9 7 1.9 7 1.9 7P.4 5

Tabl e 2 9

. Tota l Lea d Orga n Conten t i n Microgram s fo r Males

.

Inpu t t o Bloo d 13 0 Microgram s pe r Day
.

AG E BLOO D BON E LIVE R

1 2 3 4 5 6 7 8 9 1 0 1 1 1 2 1 3 1 4 1 5 1 6 1 7 1 8 1 9 2 0 339.6 5

598.7 7 637.9 1 672.9 3 754.6 8 829.9 6 870.7 2 748.9 3 773.7 4 948.6 6 1406.3 7 1438.9 8 1351.0 3 1377.5 7 1712.2 2 1756.6 4 1799.9 7 1842.2 6 1883.5 4 1923.8 2 3116 8

5021 7 6737 1 8271 9 9846 8 11429 5 13217 6 15432 2 17542 5 20225 4 21873 9 2349B 1 25323 4 27076 8 29498 8 31920 1 34283 2 365B9 4 38840 2 41036 8 90

. 1

245. 7 261. 8 276. 2 525. 4 886. 2 1268. 3 1091. 6 1128. 0 1382. 4 2051. 1 2098. 8 1970. 8 2009. 6 2842. 1 2916. 1 2988. 2 3058. 7 3127. 4 3194. 5 KIDNE Y

112. 7 199

. 1 212. 2 223. 9 251

. 1 276. 2 289. 8 249. 3 257. 6 315. 8 468. 4 479. 3 450. 0 458. 9 570. 2 585. 0 599. 5 613. 6 627. 3 640. 8 URIN E

26

. 1 6 46

. 1 1 49

. 1 3 51

. B 3 58

. 1 2 57

. 5 3 60.3 5 51.9 1 53.6 3 65.7 6 48.7 4 49.8 7 46.8 2 47.7 4 59.3 4 30.4 4 31

. 1 9 31.9 2 32.6 4 33.3 4 FECE S

12.4 8 5.9 6 6.3 5 6.7 0 12.75 21.5 0 12.0 1 10.3 4 10.6 9 13.1 0 19.4 3 19.B B 18.6 7 19.0 4 26.9 2 27.6 2 28.3 1 28.9 7 29.6 3 30.2 6P.4 6

Tabl e 3 0

. Orga n Lea d Concentration"fo r Male s a s a Functio n o f Age
.

Inpu t t o Bloo d 13 0 u g pe r day

.

AG E BLOO D ug/m l BON E ug/ g as h LIVE R ug/ g KIDNE Y ug/ g

1 2 3 4 5 6 7 8 9 1 0 1 1 1 2 1 3 1 4 1 5 1 6 1 7 1 8 1 9 2 0 0.38 6

0.52 5 0.47 6 0.45 5 0.47 2 0.44 9 0.42 3 0.32 3 0.30 1 0.33 8 0.45 5 0.43 1 0.36 2 0.32 6 0.36 7 0.34 7 0.33 9 0

. 33 6 0.34 2 0.35 0 115.3 2

123.8 7 138.4 8 153.03 165.6 1 176.2 1 188.1 0 190.33 190.9 0 187.0 9 174

. 80 ~ 161.3 0 150.1 6 140.3 1 135.4 2 132.1 1 130.3 7 130.1 7 134.3 1 140.5 9 0.3 3 0.7 2 0.6 4 0.6 2 1

. 1 0 1.5 8 2.0 7 1.5 7 1.4 7 1.6 3 2.2 3 2.0 9 1.7 6 1.6 0 2.0 4 1.9 3 1.8 9 1.8 7 1.8 8 1.8 8 2.3 5

3.3 2 2.9 5 2.8 7 2.9 9 2.7 9 2.6 8 2.0 3 1.9 1 2

. 1 1 2.8 9

. 2.7 1 2.2 7 2.0 7 2.3 2 2.1 9 2

. 1 5 2

. 1 3 2.1 3 2

. 1 4O -f l C Dvi f hc nJ i 0 4 f O »-

• O -f l C Dvl t hc nJi 0 4 1 0 i
t- 0 1 0 » - i - H - ft

*-. ^ t-t

t-t l - OO-fl-OCDCDJiJsUICnOCDCO-OCOCDvlthChO l v l tO 00 0 1 -f l J> C

O Cf l J i i - t-

0 0 4 O 0 4 -f l ftO O

D J i t h t- C D C- 4 C D H * 0 4 0 4 J

. - 0 J i H * 0

4 t h v l 0

4 1 0 J > C

h J i U I mji-oj>vjNocn-ochcnthfocnvicovich-ocDv j HUS | 0 4 0 - 0 4 0 4 f

hvl c n0 4 0 - J i O •-*

• 0 4 - 0 C D0 1 C D

J » J s 0 4 0 4 0 4 0 4 t-

0 tO tO t- 0 K J• - H * H - » - »- * J i *- » - 0 C hJ i f*

- 0 v l U l O J H * C O C hJ » tO O 0 0 v j *- C O J i -f l 0 4 vl H * tO 0 4 U I v l C

O

- o K Jo K Jv

i fr c nv i o c no o - A O Jv l U l - 0 C hto 0 4 0 - - 0 K ) c- 4 o o o c n c nc- 4 J i C-I o c n jiocnvi-oi-uith^»--ojscojicocncoc h o j i c n -Ac h j i c h c n t o -o 0 4 0 4 vj o i t o 0

4 o c n

0 4 0 4 0 1 0 4 0 4 O

Jt- 0 K l M K J» - H * »•

* H J i O J t- 0 1- 0 Ho ^ Ht O H4»H Hc- J - 0 C nt O K J K J Jifh-fli-*JiChChtOChOOOi-'V|0-cnCh-flCOCh-f l O C D0 4 C O O O J » t o O C O G DJ > c nU I -f c Ul vi • - J s v j tO O - 0 t-t

J i v l tOJ s K

J C O v i vi t h> 0 Js 0 0 J i - 0 C

hO

C h C h fr fr fr fr

J i J s tf l U I 0 1 1 0 K J O J t o J O tO MH H -Av|thJi01»-'-0a3i-*OJiVlthi-*-0vlJit0>-'t 0 ocnocnojijijithjiOvitDtovioi-'COJsi- * •-thoothOOMfhH-jii-'JicnojijiH'-cnjij i

U 0 4 0 4 O I 0 4 t

hUI Ul U I UI v l c

nUl t ht ho - u i c nJ > to c nc nJ i o i to o i *

- o 0 1 t o o vi u i c

n• - t o c nt- o - o O D -Oi-OlUlvlOJijsvlJsOOvl-OO-OCnCO-OChH - ocnoo-ocoi-'t-ot-oi-*--OH*o^oocn-oi-*i-'thv i

0 1 0 4 0 4 0 4 1 0 tO tO tO K JK O H " H * UHHO-COJOO^O^ H •-*»- * t O t-t H * *- • K J0 4 0 4 vl t

hth0 4 Cn-flt-0Jivl-OUli-*Ji-fl»-'UlH*-O'-vltO0DJiJ i

- A O O - A U i - A o •-•»- •t o O i - J > J s c n 0 1 K J J s t-0 J s I 3> I C J i m

I C O i r i a i o i a

i c o i o i z i m

i r I H H i < i m I 3 3

i x i t-t i a i z i m i - <

i c I 3 3 I H H i z t m
i - n i m i n i m I O J H

J U cr i— • n s 0 4

3 H TJ O C rf rr ai— • rf o r ra C O J U i - Q

. 

### o o • aT i n H * fl| J i 3 i~. " n z o f- 3 ra 3 ff n o 0 U D 1 J U 3 i n T J fro n -, T 0 D i Q I U 1

- < fl)

• 3 I B
•+, O T Z J U H- »
• D U lTabl e 3 2

. Orga n Lea d Concentratio n fo r Male s a s a Functio n o f Age
. Inpu t t o Bloo d 14 0 u g pe r <pay
AG E BLOO D ug/m l BON E ug/ g as h LIVE R ug/ g KIDNE Y ug/ g

o 4 5 6 7 8 9 1 0 1 1 1 2 1 3 1 4 1 5 1 6 1 7 1 8 1 9 2 0 0.41 6

0.56 6 0.513 ' 0.49 0 0.50 8 0.48 3 0.45 5 0.34 8 0.32 4 0.36 4 0.49 0 0.46 4 0.39 0 0.35 1 0.39 6 0.37 4 0.36 5 0.36 2 0.36 9 0.37 7 124.1 9

133.4 0 149.1 4 164.8 0 178.3 4 189.7 6 202.5 7 204.9 7 205.5 9 201.4 8 188.2 5 173.7 1 161.7 1 151.1 1 145.83 142.2 7 140.4 0 140.1 9 144.6 4 151.4 0 0.3 6 0.7 8 0.6 9 0.6 7 1.1 9 1.7 0 2

. 2 3 1.6 9 1.5 9 1.7 5 2.4 1 2.2 5 1.8 9 1.7 2 2.2 0 2.0 8 2.0 4 2.0 2 2.0 2 2.0 2 2.5 3 3.5 7 3.1 7 3.0 9 3.2 2 3.0 0 2.8 9 2.1 8 2.0 6 2.2 7 3.1 1 2.9 2 2.4 5 2.2 3 2.5 0 2.3 6 2.3 1 2.2 9 2.3 0 2.3 0P.4 9

Tabl e 3 3

. Tota l Lea d Orga n Conten t i n Microgram s fo r Males

.

Inpu t t o Bloo d 15 0 Microgram s pe r Day
.

AG E BLOO D BON E LIVE R

1 2
4 5 6 7 8 9 1 0 1 1 1 2 1 3 1 4 1 5 1 6 1 7 1 8 1 9 2 0 391.9 0

690.B B 736.0 5 776.4 5 870.7 8 957.6 5 1004.6 8 864.1 5 B92.7 8 1094.6 1 1622.7 3

. 1660.3 6 1558.8 8 1589.5 0 1975.6 3 2026.8 9 2076.8 9 2125.6 9 2173.3 1 2219.7 9 -

3596 3 5794 3 7773 6 9544 5 11361 7 13187 9 15251 1 17806 4 20241 4 23337 0 252391

. 27113 2 29219 4 31242 4 34037 0 36830 9 39557 5 42218 6 44815 6 47350 2 103. 9

283. 5 302. 1 318. 7 606. 2 1022. 6 1463. 5 1259. 6 1301.5 1595. 1 2366. 6 2421. 7 2274. 0 2318. 8 3279. 3 3364. 7 3448. 0 3529. 2 3608. 5 3685. 9 KIDNE Y

130. 0 229. 7 244. 8 25B. 3 289. 7 318. 7 334. 3 287. 7 297. 2 364. 3 540. 4 553. 0 519. 2 529. 5 657. 9 675. 0 691. 7 708. 0 723. 9 739. 4 URIN E

30

. 1 8 53.2 1 56.6 9 59.8 0 67.0 6 66.3 8 69.6 4 59.9 0 61.8 8 75.8 7 56.2 4 57.5 4 54.0 3 55.0 9 68.4 7

o o . 1 2 35.9 9 36

. B 4 37.6 6 3B.4 7 FECE S

14.4 0 6.8 8 7

. 3 3 7.7 3 14.7 1 24.8 1 13.8 6 11.9 3 12.3 3 15

. 1 1 22.4 2 22.9 4 21.5 4 21.9 7 31.0 6 31.8 7 32.6 6 33.4 3 34

. 1 8 34.9 2^Tabl e 3 4

. Orga n Lea d Concentratio n fo r Male s a s a Functio n o f Age
. Inpu t t o Bloo d 15 0 u g pe r day

.

AG E

1
r> y 4 5 6 7 8 9 1 0 1 1 1 2 1 3 1 4 1 5 1 6 1 7 1 8 1 9 2 0 BLOO D ug/m l

0.44 5 0.60 6 0.54 9 0.52 5 0.54 4 0.51 8 0.48 8 0.37 2 0.34 7 0.39 0 0.52 5 0.49 7 0.41 8 0.37 6 • 0.42 4 0.40 1 0.39 1 0.38 8 0.39 5 0.40 4 BON L ug/ g as h

133.0 6 142.9 3 159.7 9 176.5 7 191.0 8 203.3 1 217.0 3 219.6 1 220.2 7 215.8 7 201.6 9 186.1 2 173.2 6 161.9 0 156.2 5 152.4 3 150.4 2 150.2 0 154.9 7 162.2 2 LIVE R ug/ g KIDNE Y ug/ g

0.3 8 0.8 3 0.7 4 0.7 2 1.2 7 1.8 2 2.3 9 1.8 1 1.7 0 1.8 8 2.5 8 2.4 1 2.0 3 1.8 4 2.3 5 2.2 2 2.1 8 2.1 6 2.1 7 2.1 7 2.7 1

3

. 8 3 3.4 0 T " T i O
. O l 3.4 5 3.2 2 3.1 0 2.3 4 2.2 0 2.4 3 3

. 3 4 3

. 1 2 2.6 2 2.3 8 2.6 7 2.5 3 2.4 8 2.4 6 2.4 6 2.4 6i Q

C h « f DP.5 2



# 10 0

o C D



# - a a C D
C D



### C O



# " o

a > ID 

# m

> T C D C



# - o

C D > 

# o C D *



# c2 0 r

1 ti/ 2 

### Overal l Bloo d =1 6 day

s

ti / Bloo d t o Kidne y = 15days ti / Kidne y t o Bloo d =68day s

.t./ 2 

### = 22day s



## •ti/ Kidne y t o Bloo d = 6. 8 day s



# 0 2 0 4 0 6 0 80 ' 100 Tim e Pos t Injectio n t

o Bloo d (Days )

Figur e 2