.o ~ Helping Make 

The Chemical Company Products BetterT"" 

~ °°°° ~ °°a '" V 

Via Federal Express 

United States Environmental Protection Agency - East Attn: TSCA Section 8(e) 

Room 6428 ~ 111111111 i 1 11 1111I llll~ ll IIIIIl l ~iil~ 1 2~1~~ ~~~I 

1201 Constitution Avenue, NW 

Washington, DC 20004 

Subject: Notice in Accordance with Section 8(e): Results of a Test Study in Wistar Rats with 

3-Dimethyl-aminopropyl-olicacid-amid (CAS No: 109-28-4) 

Dear Sir/Madam: 

BASF Corporation and Elastogran GmbH are submitting results of a Test Study in Wistar Rats with 3- 

Dimethyl-aminopropyl-olicacid-amid (CAS No: 109-28-4), conducted by BASF SE, Ludwigshafen, Germany. 

The test substance is used as a release agent in polyurethane systems. 

The test compound 3-Dimethyl-aminopropyl-olicacid-amid, administration by gavage for 14 days in Wistar 

rats [CrI:WI(HAN) Charles River, Sulzfeld, Germany]. 

The test substance was administered to groups of 3 male as well as 3 female animals at dose levels of 1000 

and 300 mg/kg body weight/day. 

The study was carried out to investigate if the animals tolerate the test article at the offered dose levels by 

gavage to select doses for subsequent studies. 

The following severe clinical signs of toxicity were observed in male animals: 

Dose level (mg/kg 

body wei htlday 

0 300 1000 

No. of animals/group 3 3 3 

Arousal 0 1 3 

Extended abdomen 0 0 1 

Eylid halfclosure 0 1 3 

High stepping gait 0 1 0 

Labored respiration 0 1 2 

Piloerection 0 1 3 

Reduced general condition 0 0 3 

Respiration sounds 0 1 0 

Salivation 0 3 3 

Found dead (day 5) 0 1 1 

Sacrificed moribund 0 0 1 

BASF Corporation 

100 Campus Drive Contiris

Florham Park, NJ 07932 ~ 

Tel: (800) 526-1072 

www.basf.com/usa 3 ) zz D, vk4 
d ' 

4 s 

.- BASF 

The Chemical Company 

United States Environmental Protection Agency — East 

June 9, 2008 

Page 2 

The following severe clinical signs of toxicity were observed in female animals: 

Dose level (mg/kg 

body weight/day) 

0 300 1000 

No. of animals/group 3 3 3 

Abdominal position 0 1 0 

Arousal 0 1 2 

Extended abdomen 0 0 1 

Eyfid halfclosure 0 3 2 

Labored respiration 0 1 2 

Piloerection 0 1 3 

Reduced general condition 0 0 2 

Respiration sounds 0 3 2 

Salivation 0 3 3 

Squatting posture 0 0 3 

Found dead (day 6) 0 0 2 

Sacrificed moribund 0 0 1 

BASF Corporation understands that reporting of the results from this study under TSCA 8(e) is in accordance 

with EPA's policy. 

If you have any questions, please call Janet Cerra at (973) 245-6693. 

Sincerely, 

Janet Cerra 

Product Regulatory Center of Expertise 

North America 

/jc 

872"a No Confid Letter.doc 

BASF Corporation 

100 Campus Drive 

Florham Park, NJ 07932 

Tel: (800) 526-1072 

www.badcom/usa 
Page 1 of 1 

I ti 

From: Origin ID: LKKA (973)245-6693 

Janet Cerra Fuffi& 

BASF EWes` 

100 Campus Drive ~ 

Florham Park, NJ 07932 

GL5170707l21 

SHIP T0: (202) 564-8930 BILL SENDER 

Attn: TSCA Section 8e 

USEPA East 

Room 6428 

1201 Constitution Avenue, NW 

Washington, DC 20004 

Ship Date: 11JUN08 

AdWgt:1 LB 

System#: 448753311NET8010 

Accountf#: S ********* 

NINGIIAIII ~ IIII~IGIp 

THU -12JUN A1 

TRK# 

Au-4-i 79191493 3906 

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STANDARD OVERNIGHT 

20004 

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