**UNITED            STATES **

**SECURITIES            AND EXCHANGE COMMISSION **

**WASHINGTON,            D.C. 20549**

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**FORM            10-K/A**

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**            ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE            ACT OF            1934**

**For            the fiscal year ended December 31, 2005**

**OR            **

**            TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE            ACT            OF 1934 **

**For            the transition period from to **

**Commission            file number: 000-19122**

**APHTON            CORPORATION **

**(Exact            Name of Registrant as Specified in Its Charter) **

| **Delaware**                                                                                                                         |   | **95-3640931**                                                                        |
|--------------------------------------------------------------------------------------------------------------------------------------|--------|---------------------------------------------------------------------------------------|
| **(State                      or Other Jurisdiction****of                      Incorporation or Organization)**                      |   | **(I.R.S.                      Employer****Identification                      No.)** |
|                                                                                                                                 |   |                                                                                  |
| **8                      Penn Center****1628                      JFK Boulevard****Philadelphia,                      Pennsylvania** |   | **19103**                                                                             |
| **(Address                      of Principal Executive Offices)**                                                                    |   | **(Zip                      Code)**                                                   |

**Registrant’s            telephone number, including area code:**

**(215)            218-4340**

**Securities            registered pursuant to Section 12(b) of the Act: **

**None**

**Securities            registered pursuant to Section 12(g) of the Act: **

**Common            Stock, $.001 par value**

**67,056,428**

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**EXPLANATORY          NOTE**

**PART        III**

| **ITEM                  10.** | **DIRECTORS                  AND EXECUTIVE OFFICERS OF THE                  REGISTRANT** |
|-------------------------------|------------------------------------------------------------------------------------------|

**Board        of Directors**

| **Class                  I**          |   | **Class                  II**            |   | **Class                  III**     |
|---------------------------------------|--------|------------------------------------------|--------|------------------------------------|
| David                  H. Sachs, M.D. |   | Patrick                  T. Mooney, M.D. |   | William                  A. Hasler |
| Robert                  S. Basso      |   | Georges                  Hibon           |   |                               |
| Vincent                  D. Enright   |   |                                     |   |                               |

*Robert        S. Basso*

*Vincent        D. Enright*

*William        A. Hasler*

----

*Georges        Hibon*
* *
*in vitro*

*Patrick        T. Mooney, M.D.*

*David          H. Sachs, M.D*

**Executive        Officers**

| **Name**                                 | **Age** | **Position**                                                                                                  |
|------------------------------------------|---------|---------------------------------------------------------------------------------------------------------------|
| Patrick                  T. Mooney, M.D. | 38      | Chairman,                  President, Chief Executive Officer and Director                                    |
| James                  F. Smith, CPA     | 56      | Senior                  Vice President, Chief Financial Officer and Chief Accounting                  Officer |
| Susan                  A. Watson, Ph.D.  | 44      | Senior                  Vice President and Chief Scientific                  Officer                          |

*James        F. Smith, CPA. *

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*Susan        A. Watson, Ph.D. *

**Audit        Committee of the Board of Directors**

**Family        Relationships**

**Section        16(a) Beneficial Ownership Reporting Compliance**

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**Code        of Ethics**

**ITEM        11.**
**EXECUTIVE        COMPENSATION**

**Summary        Compensation Table**

|                                                 |     | **Annual                    Compensation** |                             | **Long-Term                    Compensation Awards** |                                                            |       |
|------------------------------------------------------|----------|--------------------------------------------|----------------------------------|------------------------------------------------------|-----------------------------------------------------------------|------------|
| **Name                    and Principal Position**   | **Year** | **Salary                    ($)**          | **Bonus                    ($)** |                                                 | **Other****Annual****Compen-****sation                    ($)** |       | **Restricted****Stock****Awards                    ($)** | **Securities****Underlying****Options                    (#)** |   | **All                    Other****Compen-****sation                    ($)** |   |
|  Patrick                    T. Mooney. M.D. (1) | 2005     | 396,835                                    | 240,000                          |  (2)                                            | **                                                              |       | 108,000 | 250,000 |   | 483,000 |   (3) |
| Chief                    Executive Officer           | 2004     | 385,278                                    | —                          |                                                 | **                                                              |       | — | 400,000 |   | 3,000 |   (3) |
| and                    President                     | 2003     | 180,000                                    | —                          |                                                 | **                                                              |       | — | 200,000 |   | — |   |
|  James                    F. Smith (4)          | 2005     | 240,000                                    | 144,000                          |  (5)                                            | **                                                              |       | 27,000 | 120,000 |   | 168,000 |   (6) |
| Senior                    Vice President,            | 2004     | 113,333                                    | —                          |                                                 | **                                                              |       | — | 175,000 |   | — |   |
| Chief                    Financial Officer and       | 2003     | —                                    | —                          |                                                 | **                                                              |       | — | — |   | — |   |
| Chief                    Accounting Officer          |     |                                       |                             |                                                 |                                                            |       |   |   |   |   |   |
|  Susan                    A. Watson (7)         | 2005     | 193,449                                    | —                          |                                                 | **                                                              |       | — | 120,000 |  (8) | — |   |
| Senior                    Vice President and         | 2004     | —                                    | —                          |                                                 | **                                                              |       | — | — |   | — |   |
| Chief                    Science Officer             | 2003     | —                                    | —                          |                                                 |  **                                                        |       | — | — |   | — |   |
|  Manfred                    Ruediger (9)        | 2005     | 106,926                                    | **—**                      |                                                 | 86,545                                                          |  (10) | **—** | 150,000 | (11) | 20,000 |   (12) |
| Former                    Senior Vice President,     | 2004     | —                                    | —                          |                                                 |  **                                                        |       | — | — |   | — |   |
| Chief                    Operating Officer           | 2003     | —                                    |  —                    |                                                 | **                                                              |       | — | — |   | — |   |

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**Stock        Option Grants and Exercises**

**Option        Grants in Last Fiscal Year**

| **Name**                                   | **Number                    of Securities Underlying Options Granted (#)**(1)**** | **Percent                    Total Options Granted to Employees in Fiscal Year **(2)**** | **Exercise                    or Base Price ($/Sh)** |  **Expiration                    Date** | **Potential                    Realizable Value at Assumed Annual Rates of Stock Price Appreciation                    for                    Option Term****(3)** |
|--------------------------------------------|-----------------------------------------------------------------------------------|-----------------------------------------------------------------------------------------------|------------------------------------------------------|----------------------------------------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| **5%                    ($)**              | **10%                    ($)**                                                    |
| Patrick                    T. Mooney, M.D. | 250,000                                                                           | 28.3%                                                                                         | 1.08                                                 | 4/21/15                                      | 169,802                                                                                                                                                            | 430,310 |
| James                    F. Smith          | 120,000                                                                           | 13.6%                                                                                         | 1.08                                                 | 4/21/15                                      | 81,505                                                                                                                                                             | 206,549 |
| Susan                    A. Watson         | 120,000                                                                           | 13.6%                                                                                         | 1.32                                                 | 3/04/15                                      | 99,617                                                                                                                                                             | 252,449 |
| Manfred                    Ruediger        | 150,000(4)                                                                        | 17.0%                                                                                         | 1.10                                                 | 5/10/15                                      | N/A                                                                                                                                                                | N/A |

**__________**

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**Aggregated        Option Exercises in Last Fiscal Year and Fiscal Year-End Option        Values**

| **Name**                                   |  **Shares                  Acquired on Exercise (#)** | **Value                  Realized ($)** | **Number                  of Securities Underlying Unexercised Options at Fiscal Year-End                  (#)** | **Value                  of Unexercised In-The-Money Options atFiscal Year-End                  ($)****(1)** |
|--------------------------------------------|------------------------------------------------------------|-----------------------------------------|------------------------------------------------------------------------------------------------------------------|--------------------------------------------------------------------------------------------------------------|
|  **Exercisable**                      | **Unexercisable**                                          | **Exercisable**                         | **Unexercisable**                                                                                                |
| Patrick                  T. Mooney, M.D.   | —                                                    | —                                 | 300,000                                                                                                          | 550,000                                                                                                      | — | — |
| James                  F. Smith            | —                                                    | —                                 | 62,500                                                                                                           | 232,500                                                                                                      | — | — |
| Susan                  A. Watson           | —                                                    | —                                 | —                                                                                                          | 120,000                                                                                                      |   |   |
| Manfred                  Ruediger(2)  | —                                                    | —                                 | —                                                                                                          | —                                                                                                      | — | — |

**Compensation        of Directors**

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**Employment        Agreements**

*Patrick        T. Mooney, M.D.*

*James        F. Smith*

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**Compensation        Committee Interlocks and Insider Participation **

| **ITEM                  12.** | **SECURITY                  OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT****ANDRELATED STOCKHOLDER                  MATTERS** |
|-------------------------------|----------------------------------------------------------------------------------------------------------------------------------------|

| **Name                          and Address of Beneficial Owner**                    | **Amount                          and Nature of Beneficial Ownership(1)** | **Percent                          Owned(1)** |
|--------------------------------------------------------------------------------------|---------------------------------------------------------------------------|-----------------------------------------------|
| Smith                          Barney Fund Management LLC(2)                         | 14,855,105                                                                |                                          | 19.9% |
| Michael                          A. Roth and Brian J. Stark, as joint filers(3)      | 6,969,350                                                                 |                                          | 9.9% |
| Heartland                          Advisors, Inc.(4)                                 | 6,778,873                                                                 |                                          | 9.9% |
| 3i                          Group Investments LP(5)                                  | 4,161,564                                                                 |                                          | 6.2% |
| Patrick                          T. Mooney, M.D.                                     | 582,500                                                                   | (6)                                           | * |
| William                          A. Hasler                                           | 426,000                                                                   | (7)                                           | * |
| James                          F. Smith                                              | 132,500                                                                   | (8)                                           | * |
| Robert                          S. Basso                                             | 171,166                                                                   | (9)                                           | * |
| Vincent                          Enright                                             | 75,000                                                                    | (10)                                          | * |
| Georges                          Hibon                                               | 89,000                                                                    | (11)                                          | * |
| David                          H. Sachs, M.D.                                        | 60,000                                                                    | (12)                                          | * |
| Susan                          A. Watson                                             | 30,000                                                                    | (13)                                          | * |
| Manfred                        Ruediger                                              | 353,157                                                                   | (14)                                     | * |
| All                          directors and executive officers as a group (8 persons) | 1,566,166                                                                 | (15)                                          | 2.29% |

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**Equity        Compensation Plan Information**

**ITEM        13.**
**CERTAIN        RELATIONSHIPS AND RELATED TRANSACTIONS**

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**ITEM        14.**
**PRINCIPAL        ACCOUNTANT FEES AND SERVICES**

**Independent        Certified Public Accountants’ Fees**

*Audit        Fees:*

*Audit-Related Fees:        *

*Tax        Fees: *

*All        Other Fees:*

**Pre-Approval        Policies and Procedures for Audit and Permitted Non-Audit        Services**

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**PART        IV**

**ITEM        15.**
**EXHIBITS        AND FINANCIAL STATEMENT SCHEDULES**

| **Exhibit****Number** | **Description**                                                                                                                                                                                                                                                                                                                                                                                                                                |
|-----------------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 3.1                   | Amended                  and Restated Certificate of Incorporation, as                  amended.(1)                                                                                                                                                                                                                                                                                                                                            |
| 3.3                   | Amended                  and Restated By-Laws.*                                                                                                                                                                                                                                                                                                                                                                                                |
| 4.5                   | Form                  of Warrant to purchase common stock, dated March 31, 2003, issued                  by                  Aphton Corporation to SF Capital Partners Ltd., Heartland Value                  Fund and                  Smith Barney Fundamental Value Fund Inc. (2)                                                                                                                                                      |
| 4.7                   | Form                  of Additional Warrant to purchase common stock issued by Aphton                  Corporation to SF Capital Partners Ltd. (3)                                                                                                                                                                                                                                                                                             |
| 4.8                   | Form                  of Warrant pursuant to which certain directors and officers of                  Aphton                  Corporation were granted stock options. (4)                                                                                                                                                                                                                                                                 |
| 4.9                   | Form                  of Class A Investor Warrant to purchase common stock issued to                  certain                  institutional investors on September 18, 2003. (5)                                                                                                                                                                                                                                                              |
| 4.10                  | Rights                  Agreement, dated as of August 17, 2004, between Aphton Corporation                  and the                  Rights Agent (which includes the Form of Certificate of Designations,                  as                  Exhibit A, the Form of Rights Certificate, as Exhibit B, and the                  Summary                  of Rights to Purchase Shares of Preferred Stock as Exhibit C).                  (6) |
| 10.10+                | Incentive                  and Reward Plan, as amended. (7)                                                                                                                                                                                                                                                                                                                                                                               |
| 10.11                 | Collaboration                  and License Agreement, dated as of June 22, 2004, between Aphton                  Corporation and Daiichi Pure Chemicals Co., Ltd.                  (8)                                                                                                                                                                                                                                                    |
| 10.12+                | Aphton                  Corporation 2004 Equity Participation Plan. (9)                                                                                                                                                                                                                                                                                                                                                                        |
| 10.13                 | Stock                  Purchase Agreement dated as of December 14, 2004, among Igeneon                  Krebs-                  Immunutherapie Forschungs - Und Entwicklungs-Ag ("Igeneon"), the                  holders                  of equity securities of Igeneon, and Aphton Corporation.                  (10)                                                                                                                 |
| 10.14+                | Employment                  Agreement, effective as of January 29, 2004, by and between Aphton                  Corporation and Patrick T. Mooney, M.D. (11)                                                                                                                                                                                                                                                                                   |
| 10.15+                | Employment                  Agreement, effective as of August 17, 2004, by and between Aphton                  Corporation and James F. Smith. (12)                                                                                                                                                                                                                                                                                            |
| 10.16+                | Employment                  Agreement, effective as of March 1, 2005, by and between Aphton                  Corporation and Susan Anne Watson. (13)                                                                                                                                                                                                                                                                                      |
| 10.17                 | Severance                  Agreement and Full Waiver and Release, effective June 9, 2005,                  between Dov                  Michaeli and Aphton Corporation. (14)                                                                                                                                                                                                                                                             |
| 10.18                 | Consulting                  Agreement, dated June 9, 2005, between Dov Michaeli and Aphton                  Corporation. (15)                                                                                                                                                                                                                                                                                                             |
| 10.19                 | Severance                  Agreement and Full Waiver and Release, effective July 30, 2005,                  between Frederick Jacobs and Aphton Corporation. (16)** **                                                                                                                                                                                                                                                               |

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| 10.20+  | Retention                  Agreement, effective August 12, 2005, between Aphton Corporation                  and                  Patrick T. Mooney, MD. (17)                                                                                                                                                                                                                               |
|---------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 10.21+  | Retention                  Agreement, effective August 12, 2005, between Aphton Corporation                  and James                  F. Smith. (18)                                                                                                                                                                                                                                 |
| 10.21A+ | Amendment                  to Retention Agreement, dated December 23, 2005, between the Company                  and                  James F. Smith.*                                                                                                                                                                                                                                      |
| 10.22   | Exchange                  Agreement, dated as of November 23, 2005, among Aphton Corporation,                  SF                  Capital Partners Ltd., Heartland Group, Inc., solely on behalf                  of the                  Heartland Value Fund, and Smith Barney Fundamental Value Fund Inc.                  (Nominee Name:Horizon Waves & Co.)                  (19) |

| 10.23      | Registration                  Rights Agreement, dated as of November 23, 2005, among Aphton Corporation,                  SF Capital Partners Ltd., Heartland Group, Inc., solely on behalf                  of the                  Heartland Value Fund, and Smith Barney Fundamental Value Fund Inc.                  (Nominee Name: Horizon Waves & Co.) (20)  |
|------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 21    | Subsidiaries.*                                                                                                                                                                                                                                                                                                                                                              |
| 23.1  | Consent                  of Ernst & Young LLP, Independent Registered Public Accounting                  Firm.*                                                                                                                                                                                                                                                         |
| 31.1       | Certification                  by Patrick T. Mooney, M.D., Chief Executive                  Officer, pursuant to Section 302 of the Sarbanes-Oxley Act of                  2002.**                                                                                                                                                                                          |
| 31.2       | Certification                  by James F. Smith, Chief Financial Officer,                  pursuant to Section 302 of the Sarbanes-Oxley Act of                  2002.**                                                                                                                                                                                              |
| 32.1       | Certification                by Patrick T. Mooney, M.D., Chief Executive Officer, pursuant to                Section                906 of the Sarbanes-Oxley Act of 2002.*                                                                                                                                                                                                 |
| 32.2       | Certification                by James F. Smith, Chief Financial Officer, pursuant to Section 906                of the                Sarbanes-Oxley Act of 2002.*                                                                                                                                                                                                          |

| (1) | Incorporated                  by reference to Exhibit 3.1 to the Amendment No. 2 to Registrant’s                  Registration Statement on Form S-1 filed on November                  29,2005. |
|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (2) | Incorporated                  by reference to Exhibit 4.5 to the Registrant’s Form 8-K filed on April 1,                  2003. |
|-----|---------------------------------------------------------------------------------------------------------------------------------------|

| (3) | Incorporated                  by reference to Exhibit 4.7 to the Registrant’s Registration Statement on                  Form S-3 filed on June 27, 2003. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (4) | Incorporated                  by reference to Exhibit 4.8 the Registrant’s Registration Statement on                  Form S-8 filed on July 8, 2003. |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (5) | Incorporated                  by reference to Exhibit 4.2 to the Registrant’s Registration Statement on                  Form S-3 filed on October 31, 2003. |
|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (6) | Incorporated                  by reference to Exhibit 4.9 to the Registrant’s Form 8-K filed on August                  18, 2004. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------|

| (7) | Incorporated                  by reference to Exhibit 10.6 to the Registrant’s Registration Statement on                  Form S-8 filed on July 8, 2003. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (8) | Incorporated                  by reference to Exhibit 10.11 the Registrant’s Form 10-Q for the quarter                  ended June 30, 2004. |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------|

| (9) | Incorporated                  by reference to Exhibit 10.12 the Registrant’s Registration Statement on                  Form S-8 filed on September 7,                  2004. |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (10) | Incorporated                  by reference to Exhibit 10.12 to the Registrant’s Form 8-K filed December                  15, 2004. |
|------|------------------------------------------------------------------------------------------------------------------------------------------|

| (11) | Incorporated                  by reference to Exhibit 10.14 to the Registrant's Form 10-K for                  the year                  ended December 31, 2004. |
|------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (12) | Incorporated                  by reference to Exhibit 10.15 to the Registrant's Form 10-K for                  the year                  ended December 31, 2004. |
|------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (13) | Incorporated                  by reference to Exhibit 10.16 to the Registrant's Form 10-K for                  the year                  ended December 31, 2004. |
|------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (14) | Incorporated                  by reference to Exhibit 10.17 to the Registrant's Form 10-Q for                  the                  quarter ended June 30, 2005. |
|------|------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (15) | Incorporated                  by reference to Exhibit 10.18 to the Registrant's Form 10-Q for                  the                  quarter ended June 30, 2005. |
|------|------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (16) | Incorporated                  by reference to Exhibit 10.19 to the Registrant's Form 10-Q for                  the                  quarter ended September 30, 2005. |
|------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (17) | Incorporated                  by reference to Exhibit 10.21 to the Registrant's Form 10-Q for                  the                  quarter ended September 30, 2005. |
|------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (18) | Incorporated                  by reference to Exhibit 10.22 to the Registrant's Form 10-Q for                  the                  quarter ended September 30, 2005. |
|------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (19) | Incorporated                  by reference to Exhibit 10.23 to the Registrant's From 8-K filed                  on                  November 25, 2005. |
|------|--------------------------------------------------------------------------------------------------------------------------------------------------------|

| (20) | Incorporated                  by reference to Exhibit 10.24 to the Registrant's From 8-K filed                  on                  November 25, 2005. |
|------|--------------------------------------------------------------------------------------------------------------------------------------------------------|

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**SIGNATURES**

| APHTON                  CORPORATION  |
|-------------------------------------------|
| By:                                       |  /s/                Patrick. T. Mooney, M.D. |
|                                      | Patrick                  T. Mooney, M.D.Chief                  Executive Officer, President and Chairman of the Board of                  Directors  |
| Date:                                     | May                  1, 2006 |

| **Signature** /s/                    Patrick T. Mooney, M.D.                         | **Title** Chief                    Executive Officer, President and Chairman of the                                                                             | **Date** May                    1, 2006      |
|-------------------------------------------------------------------------------------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------|---------------------------------------------------|
| **Patrick                    T. Mooney, M.D.** /s/                    James F. Smith | Board                    of Directors (Principal                    Executive Officer) Chief                    Financial Officer (Principal Financial Officer) | May                    1,                    2006 |
| **James                    F. Smith** /s/                    Robert S. Basso         | Director                                                                                                                                                             | May                    1, 2006                    |
| **Robert                    S. Basso** /s/                    Vincent D. Enright     |  Director                                                                                                                                                       | May                    1, 2006                    |
| **Vincent                    D. Enright** /s/                    William A. Hasler   | Director                                                                                                                                                             | May                    1, 2006                    |
| **William                    A. Hasler** /s/                    Georges Hibon        |  Director                                                                                                                                                       | May                    1, 2006                    |
| **Georges                    Hibon** /s/                    David H. Sachs           | Director                                                                                                                                                             | May                    1, 2006                    |
| **David                    H. Sachs**                                                |                                                                                                                                                                 |                                              |

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**Exhibit        **

**Number**
**Exhibit        Description**

31.1      Certification        by Patrick T. Mooney, M.D., Chief Executive Officer, pursuant to Section        302 of        the Sarbanes-Oxley Act of 2002. 

31.2      Certification        by James F. Smith, Chief Financial Officer, pursuant to Section 302 of the        Sarbanes-Oxley Act of 2002.

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**Exhibit        31.1**

CERTIFICATION

|   | 1. | I                  have reviewed this annual report on Form 10-K/A of Aphton Corporation;                  and |
|--------|----|----------------------------------------------------------------------------------------------------------------|

|   | 2. | Based                  on my knowledge, this report does not contain any untrue statement                  of a                  material fact or omit to state a material fact necessary to make                  the                  statements made, in light of the circumstances under which such                  statements                  were made, not misleading with respect to the period covered by                  this                  report. |
|--------|----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| By:    | /s/                  Patrick T. Mooney   |
|--------|------------------------------------------|
| Name:  | Patrick                  T. Mooney, M.D. |
| Title: | Chief                  Executive Officer |

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**Exhibit        31.2**

CERTIFICATION

|   | 1. | I                  have reviewed this annual report on Form 10-K/A of Aphton Corporation;                  and |
|--------|----|----------------------------------------------------------------------------------------------------------------|

|   | 2. | Based                  on my knowledge, this report does not contain any untrue statement                  of a                  material fact or omit to state a material fact necessary to make                  the                  statements made, in light of the circumstances under which such                  statements                  were made, not misleading with respect to the period covered by                  this                  report. |
|--------|----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| By:    | /s/                  James F. Smith      |
|--------|------------------------------------------|
| Name:  | James                  F. Smith          |
| Title: | Chief                  Financial Officer |