EXHIBIT 10.1

SECOND AMENDMENT TO CREDIT AGREEMENT

This Second Amendment to Credit Agreement (this
Amendment) dated as of July 30, 2008 is by and among Advanced Medical Optics, Inc., a Delaware corporation (the Borrower), the Guarantors, certain of the Revolving Credit Lenders and Bank of America, N.A.,
as Administrative Agent on behalf of itself and the Lenders. All capitalized terms used herein but not otherwise defined herein shall have the meanings provided to such terms in the Credit Agreement (as defined below).

W I T N E S S E T H

WHEREAS, the Borrower,
the Guarantors, the Lenders and the Administrative Agent have entered into that certain Credit Agreement dated as of April 2, 2007 (as amended or modified from time to time, the Credit Agreement);

WHEREAS, the Borrower has requested that the Revolving Credit Lenders amend the Credit Agreement as set forth herein; and

WHEREAS, the Revolving Credit Lenders have agreed to amend the Credit Agreement on the terms and conditions set forth herein.

NOW, THEREFORE, IN CONSIDERATION of the premises and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged,
the parties hereto agree as follows:

1. Amendment. The first grid in Section 8.11(a) of the Credit Agreement is hereby amended
and restated to read as follows:



|                                  |  |          
|--------------------------------- |  | ---------
|Four-Fiscal Quarter Period Ending |  | Ratio    
|September 28, 2007                |  | 5.75:1.00
|December 31, 2007                 |  | 5.75:1.00
|March 28, 2008                    |  | 5.25:1.00
|June 27, 2008                     |  | 5.25:1.00
|September 26, 2008                |  | 5.00:1.00
|December 31, 2008                 |  | 5.00:1.00
|March 27, 2009                    |  | 5.00:1.00
|June 26, 2009                     |  | 5.00:1.00
|September 25, 2009                |  | 4.75:1.00
|December 31, 2009                 |  | 4.50:1.00
|March 26, 2010                    |  | 4.50:1.00
|June 25, 2010                     |  | 4.25:1.00
|September 24, 2010                |  | 4.25:1.00
|December 31, 2010                 |  | 4.00:1.00
|March 25, 2011                    |  | 4.00:1.00
|June 24, 2011                     |  | 3.75:1.00
|September 30, 2011                |  | 3.75:1.00
|December 31, 2011 and thereafter  |  | 3.50:1.00

2. Conditions Precedent. This Amendment shall be effective upon satisfaction of the
following conditions precedent:

(a) receipt by the Administrative Agent of this Amendment executed by the Borrower, the
Guarantors, the Revolving Credit Lenders holding more than 50% of the Revolving Credit Commitments (other than Defaulting Lenders) and the Administrative Agent; and



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(b) receipt by the Administrative Agent (for distribution to the applicable Revolving
Credit Lenders) of all fees and expenses required to be paid by the Borrower on or before the date hereof.

3. Miscellaneous.

(a) The Credit Agreement (as amended by this Amendment), and the obligations of the Loan Parties thereunder and under the
other Loan Documents, are hereby ratified and confirmed and shall remain in full force and effect according to their terms.

(b) Each Guarantor (i) acknowledges and consents to all of the terms and conditions of this Amendment, (ii) affirms all of its obligations under the Loan Documents, (iii) agrees that this Amendment and all documents executed
in connection herewith do not operate to reduce or discharge its obligations under the Credit Agreement or the other Loan Documents and (iv) hereby confirms and agrees that its Guarantee shall continue and remain in full force and effect after
giving effect to this Amendment and that, notwithstanding any contrary terms in such Guarantee, such Guarantee now applies to the Credit Agreement as amended by this Amendment.

(c) The Borrower and the Guarantors hereby represent and warrant as follows:

(i) Each Loan Party has taken all necessary action to authorize the execution, delivery and performance of this Amendment.

(ii) This Amendment has been duly executed and delivered by the Loan Parties and constitutes each of the Loan Parties legal, valid
and binding obligations, enforceable in accordance with its terms, except as such enforceability may be subject to (A) bankruptcy, insolvency, reorganization, fraudulent conveyance or transfer, moratorium or similar laws affecting
creditors rights generally and (B) general principles of equity (regardless of whether such enforceability is considered in a proceeding at law or in equity).

(iii) No consent, approval, authorization or order of, or filing, registration or qualification with, any court or governmental authority
or third party is required in connection with the execution, delivery or performance by any Loan Party of this Amendment, other than those of the Revolving Credit Lenders and the Administrative Agent and those that have already been obtained and are
in full force and effect as of the date hereof.

(d) The Loan Parties represent and warrant to the Lenders that (i) the
representations and warranties of the Loan Parties set forth in Article VI of the Credit Agreement and in each other Loan Document are true and correct in all material respects as of the date hereof with the same effect as if made on and as of the
date hereof, except to the extent such representations and warranties expressly relate solely to an earlier date and (ii) no event has occurred and is continuing which constitutes a Default or an Event of Default.

(e) The Borrower agrees to pay all reasonable and documented out-of-pocket costs and expenses of the Administrative Agent in connection
with the preparation, execution and delivery of this Amendment, including without limitation the reasonable fees and expenses of Moore & Van Allen PLLC.

(f) This Amendment may be executed in any number of counterparts, each of which when so executed and delivered shall be an original, but
all of which shall constitute one and the same instrument. Delivery of an executed counterpart of this Amendment by telecopy, facsimile or electronic delivery (in pdf format) shall be effective as an original and shall constitute a representation
that an executed original shall be delivered.



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(g) THIS AMENDMENT AND THE RIGHTS AND OBLIGATIONS OF THE PARTIES HEREUNDER SHALL BE
GOVERNED BY AND CONSTRUED AND INTERPRETED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK.

[Signature Pages Follow]



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IN WITNESS WHEREOF, each of the parties hereto has caused a counterpart of this Amendment to be duly
executed and delivered as of the date and year first above written.



|          |  |                                                       |  |                                                     
|--------- |  | ----------------------------------------------------- |  | ----------------------------------------------------
|BORROWER: |  | ADVANCED MEDICAL OPTICS, INC., a Delaware
corporation
|          |  |                                                      
|          |  | By:                                                   |  | /s/ MICHAEL J. LAMBERT                              
|          |  | Name:                                                 |  | Michael J. Lambert                                  
|          |  | Title:                                                |  | Executive Vice President and Chief Financial Officer



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IN WITNESS WHEREOF, each of the parties hereto has caused a counterpart of this Amendment to be duly
executed and delivered as of the date and year first above written.



|            |  |                                                                                                                  |  |                             
|----------- |  | ---------------------------------------------------------------------------------------------------------------- |  | ----------------------------
|GUARANTORS: |  | AMO HOLDINGS, INC., a Delaware
corporation                                                                      
|            |  |                                                                                                                 
|            |  | By:                                                                                                              |  | /s/ VINCENT E. SCULLIN, JR. 
|            |  | Name:                                                                                                            |  | Vincent E. Scullin, Jr.     
|            |  | Title:                                                                                                           |  | Vice President and Treasurer
|            | 
|            |  | AMO MANUFACTURING USA, LLC (formerly known as Visx, Incorporated), a Delaware limited liability company         
|            |  |                                                                                                                 
|            |  | By:                                                                                                              |  | /s/ VINCENT E. SCULLIN, JR. 
|            |  | Name:                                                                                                            |  | Vincent E. Scullin, Jr.     
|            |  | Title:                                                                                                           |  | Vice President and Treasurer
|            | 
|            |  | AMO USA, LLC (formerly known as AMO USA, INC.), a Delaware limited liability company                            
|            |  |                                                                                                                 
|            |  | By:                                                                                                              |  | /s/ VINCENT E. SCULLIN, JR. 
|            |  | Name:                                                                                                            |  | Vincent E. Scullin, Jr.     
|            |  | Title:                                                                                                           |  | Vice President and Treasurer
|            | 
|            |  | QUEST VISION TECHNOLOGY, INC., a California
corporation                                                         
|            |  |                                                                                                                 
|            |  | By:                                                                                                              |  | /s/ VINCENT E. SCULLIN, JR. 
|            |  | Name:                                                                                                            |  | Vincent E. Scullin, Jr.     
|            |  | Title:                                                                                                           |  | Vice President and Treasurer
|            | 
|            |  | AMO WAVEFRONT SCIENCES, LLC (formerly known as WaveFront Sciences, Inc.), a New Mexico limited liability company
|            |  |                                                                                                                 
|            |  | By:                                                                                                              |  | /s/ VINCENT E. SCULLIN, JR. 
|            |  | Name:                                                                                                            |  | Vincent E. Scullin, Jr.     
|            |  | Title:                                                                                                           |  | Vice President and Treasurer
|            | 
|            |  | AMO DEVELOPMENT, LLC (formerly known as Intralase Corp.), a Delaware limited liability company                  
|            |  |                                                                                                                 
|            |  | By:                                                                                                              |  | /s/ VINCENT E. SCULLIN, JR. 
|            |  | Name:                                                                                                            |  | Vincent E. Scullin, Jr.     
|            |  | Title:                                                                                                           |  | Vice President and Treasurer
|            | 
|            |  | AMO SALES AND SERVICE, INC., a Delaware
corporation                                                             
|            |  |                                                                                                                 
|            |  | By:                                                                                                              |  | /s/ VINCENT E. SCULLIN, JR. 
|            |  | Name:                                                                                                            |  | Vincent E. Scullin, Jr.     
|            |  | Title:                                                                                                           |  | Vice President and Treasurer



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| |  |                                                                          |  |                             
| |  | ------------------------------------------------------------------------ |  | ----------------------------
| |  | AMO US HOLDINGS, INC., a Delaware
corporation                           
| |  |                                                                         
| |  | By:                                                                      |  | /s/ VINCENT E. SCULLIN, JR. 
| |  | Name:                                                                    |  | Vincent E. Scullin, Jr.     
| |  | Title:                                                                   |  | Vice President and Treasurer
| | 
| |  | AMO USA SALES HOLDINGS, INC., a Delaware
corporation                    
| |  |                                                                         
| |  | By:                                                                      |  | /s/ VINCENT E. SCULLIN, JR. 
| |  | Name:                                                                    |  | Vincent E. Scullin, Jr.     
| |  | Title:                                                                   |  | Vice President and Treasurer
| | 
| |  | INTEGRATED SURGICAL SOLUTIONS, LLC, a
Delaware limited liability company
| |  |                                                                         
| |  | By:                                                                      |  | /s/ VINCENT E. SCULLIN, JR. 
| |  | Name:                                                                    |  | Vincent E. Scullin, Jr.     
| |  | Title:                                                                   |  | Vice President and Treasurer



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IN WITNESS WHEREOF, each of the parties hereto has caused a counterpart of this Amendment to be duly
executed and delivered as of the date and year first above written.



| |  |                                                |  |                 
| |  | ---------------------------------------------- |  | ----------------
| |  | BANK OF AMERICA, N.A., as Administrative
Agent
| |  |                                               
| |  | By:                                            |  | /s/ ALYSA TRAKAS
| |  | Name:                                          |  | Alysa Trakas    
| |  | Title:                                         |  | Vice President  



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IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed as of the date
first above written.



| |  |                                                     |  |                 
| |  | --------------------------------------------------- |  | ----------------
| |  | BANK OF AMERICA, N.A., as a Revolving Credit
Lender
| |  |                                                    
| |  | By:                                                 |  | /s/ ALYSA TRAKAS
| |  | Name:                                               |  | Alysa Trakas    
| |  | Title:                                              |  | Vice President  



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IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed as of the date
first above written.



| |  |               |  |                 
| |  | ------------- |  | ----------------
| |  | CITIBANK N.A.
| |  |              
| |  | By:           |  | /s/ ALLEN FISHER
| |  | Name:         |  | Allen Fisher    
| |  | Title:        |  | Vice President  



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IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed as of the date
first above written.



| |  |                                                                   |  |                       
| |  | ----------------------------------------------------------------- |  | ----------------------
| |  | COMMERZBANK AKTIENGESELLSCHAFT NEW YORK AND GRAND CAYMAN BRANCHES
| |  |                                                                  
| |  | By:                                                               |  | /s/ ANDREW R. CAMPBELL
| |  | Name:                                                             |  | Andrew R. Campbell    
| |  | Title:                                                            |  | Senior Vice President 
| |  |                                                                  
| |  | By:                                                               |  | /s/ ANTHONY GIRALDI   
| |  | Name:                                                             |  | Anthony Giraldi       
| |  | Title:                                                            |  | Vice President        



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IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed as of the date
first above written.



| |  |                       |  |                       
| |  | --------------------- |  | ----------------------
| |  | JP MORGAN CHASE, N.A.
| |  |                      
| |  | By:                   |  | /s/ CAMILLE FARNSWORTH
| |  | Name:                 |  | Camille Farnsworth    
| |  | Title:                |  | Vice President        



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IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed as of the date
first above written.



| |  |                                |  |                         
| |  | ------------------------------ |  | ------------------------
| |  | PNC BANK, NATIONAL ASSOCIATION
| |  |                               
| |  | By:                            |  | /s/ DOROTHY G.W. BRAILER
| |  | Name:                          |  | Dorothy G.W. Brailer    
| |  | Title:                         |  | Vice President          



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IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed as of the date
first above written.



| |  |                       |  |                   
| |  | --------------------- |  | ------------------
| |  | UBS LOAN FINANCE, LLC
| |  |                      
| |  | By:                   |  | /s/ DAVID B. JULIE
| |  | Name:                 |  | David B. Julie    
| |  | Title:                |  | Associate Director
| |  |                      
| |  | By:                   |  | /s/ IRIA R. OTSA  
| |  | Name:                 |  | Iria R. Otsa      
| |  | Title:                |  | Associate Director



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IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed as of the date
first above written.



| |  |                                |  |                     
| |  | ------------------------------ |  | --------------------
| |  | UNION BANK OF CALIFORNIA, N.A.
| |  |                               
| |  | By:                            |  | /s/ STEPHEN W. DUNNE
| |  | Name:                          |  | Stephen W. Dunne    
| |  | Title:                         |  | Vice President      



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IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed as of the date
first above written.



| |  |                                |  |                     
| |  | ------------------------------ |  | --------------------
| |  | U.S. BANK NATIONAL ASSOCIATION
| |  |                               
| |  | By:                            |  | /s/ JOYCE P. DORSETT
| |  | Name:                          |  | Joyce P. Dorsett    
| |  | Title:                         |  | Vice President      



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IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed as of the date
first above written.



| |  |                                               |  |                 
| |  | --------------------------------------------- |  | ----------------
| |  | THE GOVERNOR & COMPANY OF THE BANK OF IRELAND
| |  |                                              
| |  | By:                                           |  | /s/ ANNE DONOVAN
| |  | Name:                                         |  | Anne Donovan    
| |  | Title:                                        |  | Manager         
| |  |                                              
| |  | By:                                           |  | /s/ P. RUSHE    
| |  | Name:                                         |  | P. Rushe        
| |  | Title:                                        |  | Director        



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IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed as of the date
first above written.



| |  |                     |  |                      
| |  | ------------------- |  | ---------------------
| |  | HSBC BANK USA, N.A.
| |  |                    
| |  | By:                 |  | /s/ STEVEN T. BRENNAN
| |  | Name:               |  | Steven T. Brennan    
| |  | Title:              |  | First Vice President 



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IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed as of the date
first above written.



| |  |                      |  |                         
| |  | -------------------- |  | ------------------------
| |  | FORTIS CAPITAL CORP.
| |  |                     
| |  | By:                  |  | /s/ JOHN W. DEEGAN      
| |  | Name:                |  | John W. Deegan          
| |  | Title:               |  | Director and Group Head 
| |  |                     
| |  | By:                  |  | /s/ CAMIEL VAN DE GRIFT 
| |  | Name:                |  | Camiel Van De Grift     
| |  | Title:               |  | Assistant Vice President



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IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed as of the date
first above written.



| |  |                              |  |                                                                         
| |  | ---------------------------- |  | ------------------------------------------------------------------------
| |  | AIB DEBT MANAGEMENT, LIMITED
| |  |                             
| |  | By:                          |  | /s/ JOSEPH AUGUSTINI                                                    
| |  | Name:                        |  | Joseph Augustini                                                        
| |  | Title:                       |  | Senior Vice President Investment Advisor to AIB Debt
Management, Limited
| |  |                             
| |  | By:                          |  | /s/ SHANE ODRISCOLL                                                    
| |  | Name:                        |  | Shane ODriscoll                                                        
| |  | Title:                       |  | Senior Vice President Investment Advisor to AIB Debt
Management, Limited



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IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed as of the date
first above written.



| |  |                                      |  |                              
| |  | ------------------------------------ |  | -----------------------------
| |  | GENERAL ELECTRIC CAPITAL CORPORATION
| |  |                                     
| |  | By:                                  |  | /s/ PETER B. ZONE            
| |  | Name:                                |  | Peter B. Zone                
| |  | Title:                               |  | Its Duly Authorized Signatory



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IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed as of the date
first above written.



| |  |                                                  |  |                     
| |  | ------------------------------------------------ |  | --------------------
| |  | NATIONAL CITY BANK, as a Revolving Credit
Lender
| |  |                                                 
| |  | By:                                              |  | /s/ PAMELA K. MALONY
| |  | Name:                                            |  | Pamela K. Malony    
| |  | Title:                                           |  | Vice President      



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IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed as of the date
first above written.



| |  |                                                         |  |                         
| |  | ------------------------------------------------------- |  | ------------------------
| |  | WELLS FARGO FOOTHILL, LLC, as a Revolving
Credit Lender
| |  |                                                        
| |  | By:                                                     |  | /s/ KRISTA WADE         
| |  | Name:                                                   |  | Krista Wade             
| |  | Title:                                                  |  | Assistant Vice President



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IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed as of the date
first above written.



| |  |                                     |  |                     
| |  | ----------------------------------- |  | --------------------
| |  | GOLDMAN SACHS CREDIT PARTNERS, L.P.
| |  |                                    
| |  | By:                                 |  | /s/ ANDREW CADITZ   
| |  | Name:                               |  | Andrew Caditz       
| |  | Title:                              |  | Authorized Signatory



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IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed as of the date
first above written.



| |  |                     |  |                                                             |  |                   
| |  | ------------------- |  | ----------------------------------------------------------- |  | ------------------
| |  | LOAN FUNDING V, LLC
| |  |                    
| |  | By                  |  | Prudential Investment Management, Inc. as
Portfolio Manager
| |  |                     | 
| |  |                     |  | By:                                                         |  | /s/ WILLIAM PAPPAS
| |  |                     |  | Name:                                                       |  | William Pappas    
| |  |                     |  | Title:                                                      |  | Vice President    



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