### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D .C. 20460

March 4, 2015 OFFICE OF C HEMICAL SAFETY AND POLLUTION PREVENTION 

### Office of Pesticide Programs Registration Division (7505P)

MEMORANDUM DER for acute toxic ity stud ies for 1 00-RUAE Subject: Name of the Product Bicyclopyrone Wet Paste MUP EPA File Symbol: 1 00-RUAE DP Barcode 411826 Decision No 470870 Action Code: ROlO.O PC Code: 018986 From: Princess Campbell, DVM, MS,



# DACVPM~ **~ ~**  CITAB
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# ~ ""' Through: John Redden , M.S. .\ 

### L 

## Y'-- C I TAB Registration Division (7505P) To: Grant Rowland/Kathryn Montague RM 23 Herbicide Branch Registration Division (7505P) Applicant: Syngenta Crop Protection, LLC. Greensboro , NC 27419
FORMULATION FROM LABEL: Active Ingredient(s): Bicyclopyrone Other Ingredient(s): Total: %by wt . 

### 94.0

**~** 

### 100.0Bicyclopyrone Wet Paste MUP Reviewer: Princess Campbell, DVM 

### BACKGROUND: Syngenta Crop Protectio n, LLC has submitted a set of six acute toxicity s tudie s to support the registration ofBicyclopyrone Wet Paste MUP , an herbicide. The toxicity studies were performed by RCC Ltd, Wolferstrasse 4 , Switzerland, and Safe pharm between 2007 and 2008 (MRlDs 47841966-71 ). D eficiencies: All stud ies are in compliance with E PA guidelines ; any deficiency is not sign ificant and does not affect the outcome of the study. FINDINGS: All six studies have been classified as acceptable. The toxicology profil e i s as follows: Acute oral toxicity 

## IV acceptable Acute dermal toxicity 

## IV acceptable Acute inhalation 

## IV acceptable Primary eye irritation 

## IV acceptable Primary dermal irritation 

## IV acceptable Dermal sensitization

-ve acceptable

2 

### MRID 47841966 M RID 4784 1967 MRID 4784 1968 MRID 47841970 MRID 47841969 MRID 47841971Bicyclopyrone Wet Paste MOP Reviewer: Princess Campbell, DVM



### LABEL: PRODUCT 

### ID #: 

### 000100-01462 

### PRODUCT NAME: Bicyclopyrone Wet Paste MUP 

### PRECAUTIONARY STATEMENTS SIGNAL WORD: CAUTION Hazards to Humans and Domestic Animals: Wear: Long - s l eeved sh i rt and l ong pants, Socks, Shoes, a n d gloves. 

### First Aid: No statements are required. Category III statements may be used.

3Bicyclopyrone Wet Paste MUP Reviewer: Princess Campbell, DVM DER fi F"l S b 1100 RU E or

. I e sym o 

# - A 1. DP BARCODE : 411826 2. PC CODE: 018986 3. CURRENT DATE: February 3 , 2015 4. TEST ARTICLE: NOA449280 ; Batch # : SEZ3AP006/MILLED ; Solid beige powder ; Study/Species/Lab 

### MRID Results Study# /Date Acute oral toxicity I rat 47841966 LDso females is 

### > 5000 mg/kg mg/ kg RCC Ltd /835493 /07-05-2007 OCSPP 870.11 00; OECD 425

Acute dermal toxicity /rat 47841967 Dermal LD s o Male s/females 

### > 5000 I RCC Ltd /835504/07-17

- 2007 mg/kgbw OCSPP 870.1200; OECD 402 Acute inhalation tox icity I rat 47841968 LC s o Males and females 

### > 5.210 mg/L RCC Ltd 1845145 1 05-08-2008 MMAD= 3.10

**~m** OCSPP 870.1300 ; OECD 403 GSD = 3.22 All survived exposure (nose only). Primary Skin irritation I rabbit 47841969 Non irritating RCC Ltd /835515 1 05-11-2007 OCSPP 870.2400; OECD 404 Primary eye irritation I rabbit 47841970 Non irritating RCC Ltd 1383961 05-01-2014 OCSPP 870.2500 ; OECD 405 Dermal sensitization I mouse LLNA- 47841971 Negative. Safepharm Laboratories Ltd Positive control ( 15% HC A): /236410053/01-08-2008 OCSPP 870.2600 Core Grade K ey: A =Acceptable , S = Supplementary , U = Unacceptable , D = Data Gap
**Detailed DER completed for acute toxicity studies (6 pack) in Global Joint Review format.

4 Tox Core Cat Grade 

### IV A



### IV A 

### IV A



### IV A


### IV A



### -- A