UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

March 4, 2015 

OFFICE OF CHEMICAL SAFETY AND 

POLLUTION PREVENTION 

Office of Pesticide Programs 

Registration Division (7505P) 

MEMORANDUM DER for acute toxicity studies for 1 00-RUAE 

Subject: Name of the Product Bicyclopyrone Wet Paste MUP 

EPA File Symbol: 1 00-RUAE 

DP Barcode 411826 

Decision No 470870 

Action Code: ROlO.O 

PC Code: 018986 

From: Princess Campbell, DVM, MS, DACVPM~ ~ ~ CITAB . ~ ""' 

Through: John Redden, M.S. .\ L Y'--

CITAB 

Registration Division (7505P) 

To: Grant Rowland/Kathryn Montague RM 23 

Herbicide Branch 

Registration Division (7505P) 

Applicant: Syngenta Crop Protection, LLC. 

Greensboro, NC 27419 

FORMULATION FROM LABEL: 

Active Ingredient(s): 

Bicyclopyrone 

Other Ingredient(s): 

Total: 

%by wt. 

94.0 

~ 

100.0 
Bicyclopyrone Wet Paste MUP 

Reviewer: Princess Campbell, DVM 

BACKGROUND: 

Syngenta Crop Protection, LLC has submitted a set of six acute toxicity studies to support the 

registration ofBicyclopyrone Wet Paste MUP, an herbicide. The toxicity studies were performed 

by RCC Ltd, Wolferstrasse 4, Switzerland, and Safepharm between 2007 and 2008 (MRlDs 

47841966-71 ). 

Deficiencies: All studies are in compliance with EPA guidelines; any deficiency is not 

significant and does not affect the outcome of the study. 

FINDINGS: 

All six studies have been classified as acceptable. 

The toxicology profile is as follows: 

Acute oral toxicity IV acceptable 

Acute dermal toxicity IV acceptable 

Acute inhalation IV acceptable 

Primary eye irritation IV acceptable 

Primary dermal irritation IV acceptable 

Dermal sensitization -ve acceptable 

2 

MRID 47841966 

MRID 4 7841967 

MRID 47841968 

MRID 47841970 

MRID 47841969 

MRID 47841971 
Bicyclopyrone Wet Paste MOP 

Reviewer: Princess Campbell, DVM 

LABEL: 

PRODUCT ID #: 000100-01462 

PRODUCT NAME: Bicyclopyrone Wet Paste MUP 

PRECAUTIONARY STATEMENTS 

SIGNAL WORD: CAUTION 

Hazards to Humans and Domestic Animals: 

Wear: Long-sleeved shirt and long pants, Socks, Shoes, and gloves. 

First Aid: No statements are required. Category III statements may be used. 

3 
Bicyclopyrone Wet Paste MUP 

Reviewer: Princess Campbell, DVM 

DER fi or F"l . I e S sym b o 1100 -RU A E 

1. DP BARCODE: 411826 

2. PC CODE: 018986 

3. CURRENT DATE: February 3, 2015 

4. TEST ARTICLE: NOA449280; Batch #: SEZ3AP006/MILLED; Solid beige powder; 

Study/Species/Lab MRID Results 

Study# /Date 

Acute oral toxicity I rat 47841966 LDso females is > 5000 mg/kg mg/ kg 

RCC Ltd /835493/07-05-2007 

OCSPP 870.11 00; OECD 425 

Acute dermal toxicity /rat 47841967 Dermal LDso Males/females > 5000 

I RCC Ltd /835504/07-17-2007 mg/kgbw 

OCSPP 870.1200; OECD 402 

Acute inhalation toxicity I rat 47841968 LCso Males and females > 5.210 mg/L 

RCC Ltd 1845145105-08-2008 MMAD= 3.10 ~m 

OCSPP 870.1300; OECD 403 GSD = 3.22 

All survived exposure (nose only). 

Primary Skin irritation I rabbit 47841969 Non irritating 

RCC Ltd /835515105-11-2007 

OCSPP 870.2400; OECD 404 

Primary eye irritation I rabbit 47841970 Non irritating 

RCC Ltd 138396105-01-2014 

OCSPP 870.2500; OECD 405 

Dermal sensitization I mouse LLNA- 47841971 Negative. 

Safepharm Laboratories Ltd Positive control ( 15% HCA): 

/236410053/01-08-2008 

OCSPP 870.2600 

Core Grade Key: A =Acceptable, S = Supplementary, U = Unacceptable, D = Data Gap 

**Detailed DER completed for acute toxicity studies (6 pack) in Global Joint Review format. 

4 

Tox Core 

Cat Grade 

IV A 

IV A 

IV A 

IV A 

IV A 

-- A