### Cyromazine (PC Code 12130 1 ) Di etary Exposure a nd Risk Assessment DP #: 414945



## UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C

. 20 460

Office of Chemical Safety and Pollution Prevention



# MEMORANDUM

Octobe r 30, 2013



# SUBJECT: Cyromazine

- Acut e and Chronic Dietary and Drinking W a ter Ex posure and

Risk Assessmen t for Registration Review.

PC Code: 1 21301

Decision No.: 482882

Petition No.:

Risk Assessment Type: Dietary Assessment



# TXRNo.: NA



# MRIDNo.: NA



# FROM: Thurston Morton, C hemi s t DP Barcode: 41 494 5

R e gistration No.: NA

Regulatory Act i on : Registration Review



## Case No.:

CAS No: 66 215-27-8

40 CFR: 180 .41 4



## Risk Assessmen t Branch IV

He a lth E ffects Division (7509P)



# THROUGH: Sheila Piper, Chemist 1 

# L

Seyed Tadayo n

, Chemist

Dietary Exposure S cienc e A i. so r y Council**(DES C,**  "?) ./ 

### 1

_

## ~ • 

## ..!'



## Susa n Hummel, Branch Senior Sc ien t is t, RAB IV**~** 

### U.**~** 

### .._ 

## Hea lt h Effects Division (7509P)



# TO : James Parke r

Che mical Revi ew Manager, RMIB 1

Pest i c ide Re-e va luat ion Division (7505P)

This docum e nt provides acute and chronic dietary and drinkin g water ri s k analyses of exposures

resul ting from the use of cyromazine on foo d crops for insect control. This assessment supports

OPP's Registration Review of cy romazine.

Page 1 of23

### Cyromazine ( P C Code 121301) Dietary Expos ur e and Ri sk Assessme nt DP #: 414945



## Executive Summary



## Acute and chronic dietary risk assessmen t s was conducte d fo r cyromazine u sing the Dietary

Exposure Eva luation Mode l software with the Food Commodity Intake Database (DEEMFCIDTM)

, Ve r sion 3. 16

, wh i ch incorporates consumption data from US D A's Nationa l Health and

N utrition Examination Survey

, What We Eat in America, (NHANES/WWEIA).The analysis was

performed to suppo rt a Reg i s tr at ion Rev i ew of Cyromaz in e.

Th i s memorandum was reviewed by two peer rev i ewers ofthe DESAC, per DESAC SOP

2012. 1.

Acute Dietary Ex posure Ana l ysis Resu lt s and Characteriza ti o n

A conserva t ive acu t e dietary exposure ana l ysis was pe r formed for the general U.S. population

and various pop ul a tion s ubgrou ps. Tolerance l eve l resi du es an d 1 00% percent crop tre ated

assumpt i ons were used. DEEM defa ul t and empirica l p r ocess i ng factors we r e used to modify the

tolerance va lue s. T h e acute analysis incorporate d the peak groundwater esti mat e from

applica t ion of cyromazine to succulent beans using the PRZM-GW mode l. Acute d ie tary risk

estimates are not of concern for general population or other pop ul at i on subgroups. T h e subgroup

with the highest risk estimate was children 1- 2 y ear s old with a aPAD of 1 8%. The aP AD fo r th e

gene r al U.S. population was 7.6%.

Chro ni c Dietary Ex posure Ana l ysis Results and Characterization

A conservat i ve chronic dietary ex po sure analy sis was performed for the gene ral U.S

. population

and various popu l at i on subgroups

. Tolerance level re s idues an d 100% percent crop treated

assumptions were used. DEEM default an d empirical p ro cessing fac tor s were used to modify the

t o l erance values. T he chro ni c ana l ysis in co rp orated the 10 year average surfa c e drinking water

esti mat e from the PRZM-GW model. Chronic dietary risk estimates are no t of concern for

general pop ulat ion or other pop u l ation su b groups. The subgroup with th e highest r i s k est imat e

was children 1-2 years old w ith a cPAD of8.3%. The cPAD for the genera l U.S. pop ul ation was

3.8%.

I. Introduction



## D i etary ri s k asse ss ment incorp ora te s both exposure and toxicity of a given pesticide. For acute

and chronic assess m ents, the risk i s expressed as a perce n tage of a maximum accepta bl e dose

(i.e., t h e dose which HED has concluded will result in no unr eas on ab le adverse health effects).

This do se is r eferred to as the pop ul ation adjusted dose (PAD)

. The PAD is equivalent to the

Reference Dose (RID) divided by the FQ PA Safety Factor.

For acute and non-cancer chr onic exposures

, HE D i s co n cerned when estimated dietary risk

exceeds 100% of t he PAD. Refe r ences that disc us s the acut e a nd chro nic ris k assessments in

more detail are avai l able on the EPA/pesticid es web s ite: "Ava il able Information on Assess in g

Page 2 of23

### Cyromazine (PC C ode 121301 ) Dietary Exposure and Risk Assessment DP #: 414945



## Page 3 of 23 Exposure from Pesticides, A User’s Guide,” 6/21/2000, web link:

http://www.epa.gov/fedrgstr/EPA_PEST/2000/July/Day_12/6061.pdf ; or see SOP 99.6

(8/20/99).

The most recent dietary assessment was conducted in support of registration review of

cyromazine ( B

. Daiss & T. Morton , D 398366

, 0 1 / 3 0/ 13 ).

II. Residue Information

Residues of Concern

The metabolism of cyromazine has been studied in celery, head lettuce, and tomatoes. The

residue of concern is the parent compound cyromazine as determined by the HED Metabolism

Assessment Review Committee (MARC) (D245214, 11/4/97 ) . The metabolism of cyromazine

in plants is adequately understood and additional plant metabolism data are not required for this

proposed use on bean, succulent. Data concerning the metabolism of cyromazine in lactating

goats an d laying hens have been previously submitted. The MARC determined that the residue

of concern in livestock commodities is the parent compound, cyromazine (D245214

, J.B. Stokes

, 4/15/98).

Table 1: Summ ary of MARC Decisions for Cyromazine

Matrix Residues of Concern

For Risk Assessment For Tolerance Expression

Plants

Parent Only Parent Only Livestock

Rotational Crops

Drinking Water



## Established Tolerances

Tolerances are established (40 CFR §180.414) for residues of cyromazine in or on a variety of

commodities ranging from 0.05 ppm (livestock commodities) to 10 .0 ppm ( brassica vegetables).

Residues U sed in the Acute and Chronic Analysis

For the acute and chronic dietary analysis, tolerance level residues and 100 percent crop treated

assumptions were used for all treated commodities

. Default processing factors were used for all

processed commodities except potato and tomato commodities for which empirical processing

factors were used . R esidues used in the chronic dietary analysis are provided in Table 2.

Processing factors for potato and tomato commodities are provided in Table 4.

### Cyromazine (PC C ode 121301 ) Dietary Exposure and Risk Assessment DP #: 414945



## Page 4 of 23 Table 2. Residue Estimates Used in the Cyromazine Acute and Chronic Dietary and Drinking

Water Analysis

Commodity Tolerance (ppm)

Brassica vegetables (except broccoli) 35 .0

Cucurbit vegetables 2.0

Broccoli 1.0

Leafy vegetables (except Brassica ) 10 .0

Cotton, undelinted seed 0.1 1



### Garlic 0.2

Leek 3.0

Lima bean 1.0

Mango 0.5 2



### Mushroom 8 .0

Onion, bulb 0. 6

Onion, green 3

Pepper 3 .0

Potato 0. 75 highest FT residue

Tomato 1.0

Sweet corn ( kernel plus cob with husks removed) 0.5 1



### Succulent bean 1.41 highest FT residue

Radish roots and tops 0.5 1



### Turnip, greens 10.0

Milk 0. 1

Meat 0. 3

Fat 0.05

Meat byproduct (except kidney) 0. 3

Kidney 0. 3

Egg 0. 3

Poultry meat, fat and meat byproducts 0. 2

Bean, Succulent 2.0

Vegetable, Root and Tuber (except potato) 0.60 1



### Leaves of Root and Tuber Vegetables 0.60 1



### Vegetable, Bulb (except leek and green onion) 0.60 1



### Soybean 0. 60 1



### Vegetable Fruit (except Pepper ) 0. 60 1



### Strawberry 0. 60 1



### Cereal Grain CG 15 (except small grain) 3 

### 0. 60 1



### Forage, fodder CG 16 (except small grain) 3 

### 0.60 1



### Herbs and Spices (CG 19) 0.60 1



### Oil Seeds (CG 20) 0.60 1

1 

### Indirect or inadvertent residues.

2 

### There are no U.S. registrations on mango as of May 4, 2000.



### Table 4 . Empirically Derived Processing Factors

Crop PF

Potato, chips 1.9

Potato, dry and flour 2.6

Tomato, paste 1

Tomato, puree 1

Tomato, dried 2.4

Tomato, juice 1.5

### Cyromazine (PC C ode 121301 ) Dietary Exposure and Risk Assessment DP #: 414945



## Page 5 of 23 III. Water Data

Drinking water residues were incorporated directly into the acute and chronic dietary analys e s

( “water, direct, all sources” and “water, indirect, all sources”) and were provided by the

Environmental Fate and Effects Division (EFED; D 398026

, T. Dowen, 2/10/12 ). Because

PRZM

- GW was not available as a screening level model at the time of the cyromazine DWA and

the PRZM

- GW model is being used in FQPA drinking water assessments to estimate pe sticide

concentrations in ground water sourced drinking water, PRZM

- GW modeling for cyromazine

was conducted to update the DWA to adhere to current Agency policy. The estimated

concentrations in drinking water (EDWC) of cyromazine are not expected to exc eed 75.5 μg/L

for a daily peak concentration in ground water (acute) and 60.9 μg/L for the average

breakthrough concentration in ground water (chronic) (Table 5 ). Cyromazine is expected to

breakthrough into ground water between 3 to 7 years.

PRZM

- GW mo deling was conducted using PRZM

- GW (version 1.0). Application rate, number,

and interval are representative of the current maximum label rate for beans. The first pesticide

application date was May 1 for all the PRZM

- GW scenarios. The ground water modeli ng was conducted using a different hydrolysis half

- life (stable) and aerobic soil metabolism half

- life

(450 days) than used in the DWA (DP 398026, 2/10/12). As per input parameter guidance, the

upper 90 th 

## percent CL of mean aerobic soil metabolism half

- li fe (147.3 days) was used because

there are three aerobic soil metabolism half

- lives for cyromazine. A hydrolysis half

- life of 400

days was estimated from abiotic hydrolysis data.

Table 5 : Estimated Drinking Water Concentrations of Cyromazine in Ground Water Source Drin king Water.

Scenario Peak Chronic Breakthrough Time

μg/L Days

WI Corn 90.6 71.3 2581

NC Cotton 38.3 30.4 1089

FL Citrus 111 86.1 1104

MD Corn 94.2 77.8 1089



## IV. DEEM

- FCIDTM Program and Consumption Information

Cyromazine acute and chronic dietary exposure assessments were conducted using the Dietary

Exposure Evaluation Model software with the Food Commodity Intake Database DEEM

FCIDTM, Version 3.16, which incorporates consumption data from USDA’s National Health and

Nutrition Examina tion Survey, What We Eat in America, (NHANES/WWEIA). This dietary

survey was conducted from 2003 to 2008. The data are based on the reported consumption of

more than 20,000 individuals over two non

- consecutive survey days. Foods “as consumed”

(e.g., app le pie) are linked to EPA

- defined food commodities (e.g. apples, peeled fruit

- cooked;

fresh or N/S; baked; or wheat flour

- cooked; fresh or N/S, baked) using publicly available recipe

translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment,

consumption data are averaged for the entire U.S. population and within population subgroups,

but for acute exposure assessment are retained as individual consumption events. Based on

analysis of the 2003

- 2008 WWEIA consumption data, which took into account dietary patterns

### Cyromazine (PC C ode 121301 ) Dietary Exposure and Risk Assessment DP #: 414945



## Page 6 of 23 and survey respondents, HED concluded that it is most appropriate to report risk for the

following population subgroups: the general U.S. population, all infants (<1 year old), children

1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19, adults 20

- 49, females 13

- 49, and adults 50

- 99

years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or food

form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the

average daily consumption estimate for that food/food form. The resulting residue consumption

estimate for each food/food form is summed with the residue consumption estimates for all other

food/food forms on the commodity residue list to arrive a t the total average estimated exposure.

Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure

is performed for each population subgroup.

V. Toxicological Information

HED evaluated the toxicology data base for cyromazine and selected doses and endpoints for

chronic dietary and drinking water risk assessments provided in Table 6

.

### Cyromazine (PC C ode 121301 ) Dietary Exposure and Risk Assessment DP #: 414945



## Page 7 of 23 Table 6. Summary of Toxicological Doses and Endpoints for Cyromazine for Use in Dietary Human

Health Risk Assessments

Exposure/

Scenario Point of

Departure Uncertainty

/FQPA Safety

Factors RfD, PAD,

LOC for Risk

Assessment Study and Toxicological Effects

Acute Dietary

females 13+ No developmental effects attributable to a single dose were seen following in utero

exposures to rats and rabbits

Acute Dietary

(general population) LOAEL =

250 mg/kg UF A 

### = 10x

UF H 

### = 10x

UF L 

### = 3x aRfD = 0.83

mg/kg

aPAD = 0.83

mg/kg ACN Study in rats, MRID

49109701

LOAEL = 250 mg/kg BW based

on decreased motor activity (mean

cumulative ambulatory LMA

counts (↓ 44%) in males at the time

of peak effect on Day 0, and

decreased food consumption (p <

.01, ↓17.4%) on Day 1.

Chronic Dietary

(All Populations)

for spray drift NOAEL=

50

mg/kg/day UF A 

### = 10x

UF H 

### = 10x cRfD = 0. 5

mg/kg/day

cPAD = 0.5

mg/kg/day 2 Generation Reproductive Study

(MRID 00103197 ) co

- critical with

Chronic Carcinogenicity Study

(MRID 00103202, 00115735 ) in

the rat

LOAEL = 150 mg/kg/day for

decreased body weight and

decreased food efficiency.

LOAEL = 150 mg/kg/day for

decreased body weight

Cancer

(all routes) Not likely human carcinogen

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose

- response data and used to mark the beginning

of extrapolation to determine risk associated with lower environmentally relevant human exposures.

NOAEL = no obs erved adverse effect level. LOAEL = lowest observed adverse effect level.

UF = uncertainty factor. UF A = extrapolation from animal to human (interspecies). UF H = potential variation in sensitivity among members of the

human population (intraspecies). UF L = extrapolation from LOAEL to NOAEL: this was reduced to 3x based on the reasons explained in the text.

SF = FQPA Safety Factor.

PAD = population adjusted dose (a = acute, c = chronic).

RfD = reference dose.

MOE = margin of exposure; the maximum allowed by the Agency.

LOC = level of concern. N/A = not applicable.

*mg/L conversion to Human Equivalent Dose (HED) mg/kg/day, see text.

** the UFAwas reduced to 3x based on the reasons explained in the text.



## VI. Results

As stated above, for chronic assessments, HED is concerned when dietary risk exceeds 100% of

the PAD. The DEEM

- FCIDTM analyses estimate the dietary exposure of the U.S. population and

various population subgroups. The results reported in Table s 7 and 8 are for the general U.S.

Popula tion, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19,

females 13

- 49, adults 20

- 49, and adults 50

- 99 years.

### Cyromazine (PC C ode 121301 ) Dietary Exposure and Risk Assessment DP #: 414945



## Page 8 of 23 Results of Acute Dietary Exposure Analysis

The results of the acute dietary exposure analysis are reported in Table 7. Estimated dietary

exposures exceed HED’s level of concern (100% of the aPAD).

Table 7 : Summary of Acute Dietary (Food and Water) Exposure and Risk for Cyromazine

Population Subgroup a PAD (mg/kg/day) Acute

Exposure (mg/kg/day) % a PAD

General U.S. Population

0. 83 0.0 6 3037 7. 6

All Infants (< 1 year old) 0.0 5 4077 6. 5

Children 1

- 2 years old 0. 14 8758 1 8

Children 3

- 5 years old 0. 10 2108 1 2

Children 6

- 12 years old 0.0 6 1079 7. 4

Youth 13

- 19 years old 0.0 41088 5.0

Adults 20

- 49 years old 0.05 7766 7.0

Adults 50

- 99 years old 0.06 7807 8. 2

Females 13

- 49 years old 0.05 9258 7.1



## Results of Chronic Dietary Exposure Analysis

The results of the chronic dietary exposure analysis are reported in Table 8 . Estimated dietary

exposures exceed HED’s level of concern (100% of the cPAD).

Table 8 : Summary of Chronic Dietary (Food and Water) Exposure and Risk for Cyromazine

.

Population Subgroup cPAD (mg/kg/day) Chronic

Exposure (mg/kg/day) % cPAD

General U.S. Population

0. 50 0.01 9165 3. 8

All Infants (< 1 year old) 0.0 2 1164 4. 2

Children 1

- 2 years old 0.0 4 1309 8. 3

Children 3

- 5 years old 0.0 32 854 6. 6

Children 6

- 12 years old 0.0 2 1037 4.2

Youth 13

- 19 years old 0.01 3667 2.7

Adults 20

- 49 years old 0.01 7 346 3. 5

Adults 50

- 99 years old 0.01 8 921 3. 8

Females 13

- 49 years old 0.01 7 374 3. 5



## VII. Characterization of Inputs/Outputs

The acute and chronic dietary exposure analys e s are un refined as tolerance level residues from

and 100 percent crop treated data was used

.

HED did not attempt further refinement of the dietary exposure analys e s since exposure

estimates were <100 PAD

.

### Cyromazine (PC C ode 121301 ) Dietary Exposure and Risk Assessment DP #: 414945



## Page 9 of 23 VII. Conclusions

Acute and c hronic dietary exposure analyses were performed for the general U.S. population and

various population subgroups. The risk estimates for the general U.S. population and all

population subgroups do not exceed HED’s level of concern.

VIII. List of Attachments

1. Acute DEEM

- FCID Residue Input File.

2. Chronic DEEM

- FCID Residue Input File

3. Acute Dietary Exposure Analysis Results

4. Chronic Dietary Exposure Analysis Results

### Cyromazine (PC C ode 121301 ) Dietary Exposure and Risk Assessment DP #: 414945



## Page 10 of 23 Attachment 1 Acute and Chronic DEEM

- FCID Residue Input File

Filename: C: \ Documents and Settings \ tmorton \ My Documents \ MyFiles \ DEEM Files \ 121301 Cyromazine \ Reg

Review Risk Assessment \ 121301 Acute Tolerance Updated Water.R08

Chemical: cyromazine

RfD(Chronic): .5 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .83 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 12

- 03

- 2013/12:38:09 Program ver. 3.16, 03

- 08

- d

-----------------------------------------------------------------------------------

EPA Crop Def Res Adj.Factors Comment

Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0101050000 1AB Beet, garden, roots 0.6000 00 1.000 1.000

0101050001 1AB Beet, garden, roots

- babyfood 0.600000 1.000 1.000

0101052000 1A Beet, sugar 0.600000 1.000 1.000

0101052001 1A Beet, sugar

- babyfood 0.600000 1.000 1.000

01010 53000 1A Beet, sugar, molasses 0.600000 1.000 1.000

0101053001 1A Beet, sugar, molasses

- babyfood 0.600000 1.000 1.000

0101067000 1AB Burdock 0.600000 1.000 1.000

0101078000 1AB Carrot 0.600000 1.000 1.000

0101078001 1AB Carrot

- babyfood 0.600000 1.000 1.000

0101079000 1AB Carrot, juice 0.600000 1.000 1.000

0101084000 1AB Celeriac 0.60 0000 1.000 1.000

0101100000 1AB Chicory, roots 0.600000 1.000 1.000

0101168000 1AB Ginseng, dried 0.600000 1.000 1.000

0101190000 1AB Horseradish 0.600000 1.000 1.000

010 1250000 1AB Parsley, turnip rooted 0.600000 1.000 1.000

0101251000 1AB Parsnip 0.600000 1.000 1.000

0101251001 1AB Parsnip

- babyfood 0.600000 1.000 1.000

0101314000 1AB Radish, root s 0.600000 1.000 1.000

0101316000 1AB Radish, Oriental, roots 0.600000 1.000 1.000

0101327000 1AB Rutabaga 0.600000 1.000 1.000

0101331000 1AB Salsify , roots 0.600000 1.000 1.000

0101388000 1AB Turnip, roots 0.600000 1.000 1.000

0103015000 1CD Arrowroot, flour 0.600000 1.000 1.000

0103015001 1CD Arrowroot, flour

- babyfood 0.600000 1.000 1.000

0103017000 1CD Artichoke, Jerusalem 0.600000 1.000 1.000

0103082000 1CD Cassava 0.600000 1.000 1.000

0103082001 1CD Cassava

- babyfood 0.600000 1.000 1.00 0

0103139000 1CD Dasheen, corm 0.600000 1.000 1.000

0103166000 1CD Ginger 0.600000 1.000 1.000

0103166001 1CD Ginger

- babyfood 0.600000 1.000 1.000

0103167000 1CD Ginge r, dried 0.600000 1.000 1.000

0103296000 1C Potato, chips 0.800000 1.900 1.000 Highes

Full comment: Highest residue in 1x studies

0103297000 1C Potato, dry (granules/ flakes) 0.800000 2.600 1.000

0103297001 1C Potato, dry (granules/ flakes)

- b 0.800000 2.600 1.000

0103298000 1C Potato, flour 0.800000 2.600 1.000

0103298001 1C Potato, flour

- babyfood 0.800000 2.600 1.000

010329900 0 1C Potato, tuber, w/peel 0.800000 1.000 1.000

0103299001 1C Potato, tuber, w/peel

- babyfood 0.800000 1.000 1.000

0103300000 1C Potato, tuber, w/o peel 0.800000 1.000 1.000

0103300001 1C Potato, tuber, w/o peel

- babyfood 0.800000 1.000 1.000

0103366000 1CD Sweet potato 0.600000 1.000 1.000

0103366001 1CD Sweet potato

- babyfood 0.600000 1.000 1.000

0103371000 1CD Tanier, corm 0.600000 1.000 1.000

0103387000 1CD Turmeric 0.600000 1.000 1.000

0103406000 1CD Yam, true 0.600000 1.000 1.000

0103407000 1CD Yam bean 0.600000 1.000 1.000

0200051000 2 Beet, garden, tops 0.600000 1.000 1.000

0200101000 2 Chicory, tops 0.600000 1.000 1.000

0200140000 2 Dasheen, leaves 0.600000 1.000 1.000

0200315000 2 Radish, t ops 0.600000 1.000 1.000

0200317000 2 Radish, Oriental, tops 0.600000 1.000 1.000

0200332000 2 Salsify, tops 0.600000 1.000 1.000

0301165000 3A Garlic, bulb 0.600000 1.000 1.000

0301165001 3A Garlic, bulb

- babyfood 0.600000 1.000 1.000

### Cyromazine (PC C ode 121301 ) Dietary Exposure and Risk Assessment DP #: 414945



## Page 11 of 23 0301237000 3A Onion, bulb 0.600000 1.000 1.000

0301237001 3A Onion, bulb

- babyfood 0.600000 1.000 1.000

0301238000 3A Onion, bulb, dried 0.600000 9.000 1.000

0301238001 3A Onion, bulb, dried

- babyfood 0.600000 9.000 1.000

0301338000 3A Shallot, bulb 0.600000 1.000 1.000

0302103000 3B Chive, fresh leaves 0.600000 1.000 1.000

0302198000 3B Leek 3.000000 1.000 1.000 Highes

Full comment: Highest Residue

0302239000 3B Onion, green 3.000000 1.000 1.000

0302338500 3B Shallot, fresh leaves 0.600000 1.000 1.000

0401005000 4A Amaranth, leafy 10.000000 1.000 1.000

0401018000 4A Arugula 10.000000 1.000 1.000

0401104000 4A Chrysanth emum, garland 10.000000 1.000 1.000

0401133000 4A Cress, garden 10.000000 1.000 1.000

0401134000 4A Cress, upland 10.000000 1.000 1.000

0401138000 4A Dandelion, leaves 10.000000 1.000 1.000

0401150000 4A Endive 10.000000 1.000 1.000

0401204000 4A Lettuce, head 10.000000 1.000 1.000

0401205000 4A Lettuce, leaf 10.000000 1.000 1.000

0401248000 4A Parsley, leaves 10.000000 1.000 1.000

0401313000 4A Radicchio 10.000000 1.000 1.000

0401355000 4A Spinach 10.000000 1.000 1.000

0401355001 4A Spinach

- babyfood 10.000000 1.000 1.000

0402076000 4B Cardoon 10.000000 1.000 1.000

0402085000 4B Celery 10.000000 1.000 1.000

0402085001 4B Celery

- babyfood 10.000000 1.000 1.000

0402086000 4B Celery, juice 10.000000 1.000 1.000

0402087000 4B Celtuce 10.000000 1.000 1.000

0402152000 4B Fennel, Florence 10.000000 1.00 0 1.000

0402322000 4B Rhubarb 10.000000 1.000 1.000

0402367000 4B Swiss chard 10.000000 1.000 1.000

0501061000 5A Broccoli 35.000000 1.000 1.000

0501061001 5A Broccoli

- babyfood 35.000000 1.000 1.000

0501062000 5A Broccoli, Chinese 35.000000 1.000 1.000

0501064000 5A Brussels sprouts 35.000000 1.000 1.000

0501069000 5A Cabbage 35.000000 1.000 1.000

0501071000 5A Cabbage, Chinese, napa 35.000000 1.000 1.000

0501072000 5A Cabbage, Chinese, mustard 35.000000 1.000 1.000

0501083000 5A Cauliflower 35.000000 1. 000 1.000

0501196000 5A Kohlrabi 35.000000 1.000 1.000

0502063000 5B Broccoli raab 35.000000 1.000 1.000

0502070000 5B Cabbage, Chinese, bok choy 35.000000 1.000 1.000

0502117000 5 B Collards 35.000000 1.000 1.000

0502194000 5B Kale 35.000000 1.000 1.000

0502229000 5B Mustard greens 35.000000 1.000 1.000

0502318000 5B Rape greens 35.000000 1.000 1.000

0502389000 5B Turnip, greens 35.000000 1.000 1.000

0600347000 6 Soybean, seed 0.600000 1.000 1.000

0600349000 6 Soybean, soy milk 0.600000 1.000 1.000

0600349001 6 Soybean, soy milk

- babyfood or in 0.600000 1.000 1.000

0600350000 6 Soybean, oil 0.600000 1.000 1.000

0600350001 6 Soybean, oil

- babyfood 0.600000 1.000 1.000

0601043000 6A Bean, snap, succulent 2.000000 1.000 1.000 Highes

Full comment: Highest FT residue

0601043001 6A Bean, snap, succulent

- babyfood 2.000000 1.000 1.000

0601257000 6A Pea, edible podded, succulent 2.000000 1.000 1.000

0601349500 6AB Soybean, vegetable 2.000000 1.000 1.000

0602031000 6B Bean, broad, succulent 2.000000 1.000 1.000

0602033000 6B Bean, cowpea, succulent 2.000000 1.000 1.000

0602037000 6B Bean, lima, succulent 1.000000 1.000 1.000

0602255000 6B Pea, succulent 2.000000 1.000 1.000

0602255001 6B Pea, succulent

- babyfood 2.000000 1.000 1.000

0602259000 6B Pea, pig eon, succulent 2.000000 1.000 1.000

0603030000 6C Bean, black, seed 3.000000 1.000 1.000

0603032000 6C Bean, broad, seed 3.000000 1.000 1.000

0603034000 6C Bean, cowpea, seed 3.000000 1.000 1.000

0603035000 6C Bean, great northern, seed 3.000000 1.000 1.000

### Cyromazine (PC C ode 121301 ) Dietary Exposure and Risk Assessment DP #: 414945



## Page 12 of 23 0603036000 6C Bean, kidney, seed 3.000000 1.000 1.000

0603038000 6C Bean, lima, seed 3.000000 1.000 1.000

0603039000 6C Bean, mung, seed 3.000000 1.000 1.000

0603040000 6C Bean, navy, seed 3.000000 1.000 1.000

0603041000 6C Bean, pink, seed 3.000000 1.000 1.000

0603042000 6C Bean, pinto, seed 3.000000 1.000 1.000

0603098000 6C Chickpea, seed 3.000000 1.000 1.000

0603098001 6C Chickpea, seed

- babyfood 3.000000 1.000 1.000

0603099000 6C Chickpea, flour 3.000000 1.000 1.000

0603182000 6C Guar, seed 3.000000 1.000 1.000

0603182001 6C Guar, seed

- babyfood 3.000000 1.000 1.000

0603203000 6C Lentil, seed 3.000000 1.000 1.0 00

0603256000 6C Pea, dry 3.000000 1.000 1.000

0603256001 6C Pea, dry

- babyfood 3.000000 1.000 1.000

0603258000 6C Pea, pigeon, seed 3.000000 1.000 1.000

0603348000 6C Soybean, flour 0.600000 1.000 1.000

0603348001 6C Soybean, flour

- babyfood 0.600000 1.000 1.000

0801374000 8A Tomatillo 1.000000 1.000 1.000

0801375000 8A Tomato 1.000000 1.000 1.000

0801375001 8A Tomato

- babyfood 1.000000 1.000 1.000

0801376000 8A Tomato, paste 1.000000 1.000 1.000 tolera

Full comment: tolerance will cov er paste and puree

0801376001 8A Tomato, paste

- babyfood 1.000000 1.000 1.000

0801377000 8A Tomato, puree 1.000000 1.000 1.000

0801377001 8A Tomato, puree

- babyfood 1.000000 1.000 1.000

080137 8000 8A Tomato, dried 1.000000 2.400 1.000

0801378001 8A Tomato, dried

- babyfood 1.000000 2.400 1.000

0801379000 8A Tomato, juice 1.000000 1.500 1.000

0801380000 8A Tomato, Tree 1.000000 1.000 1.000

0802148000 8BC Eggplant 0.600000 1.000 1.000

0802234000 8BC Okra 0.600000 1.000 1.000

0802270000 8B Pepper, bell 3.000 000 1.000 1.000

0802270001 8B Pepper, bell

- babyfood 3.000000 1.000 1.000

0802271000 8B Pepper, bell, dried 3.000000 1.000 1.000

0802271001 8B Pepper, bell, dried

- babyfood 3.000000 1.000 1.000

0802 272000 8BC Pepper, nonbell 3.000000 1.000 1.000

0802272001 8BC Pepper, nonbell

- babyfood 3.000000 1.000 1.000

0802273000 8BC Pepper, nonbell, dried 3.000000 1.000 1.000

0901075000 9A Cantaloupe 2.000000 1.000 1.000

0901187000 9A Honeydew melon 2.000000 1.000 1.000

0901399000 9A Watermelon 2.000000 1.000 1.000

0901400000 9A Watermelon, juice 2.000000 1.000 1.000

0902021000 9B Balsam pear 2.000000 1.000 1.000

0902088000 9B Chayote, fruit 2.000000 1.000 1.000

0902102000 9B Chinese w axgourd 2.000000 1.000 1.000

0902135000 9B Cucumber 2.000000 1.000 1.000

0902308000 9B Pumpkin 2.000000 1.000 1.000

0902309000 9B Pumpkin, seed 2.000000 1.000 1.000

0902356000 9B Squash, summer 2.000000 1.000 1.000

0902356001 9B Squash, summer

- babyfood 2.000000 1.000 1.000

0902357000 9B Squash, winter 2.000000 1.000 1.000

0902357001 9B Squash, winter

- babyfood 2.000000 1.000 1.000

1307359000 13G Strawberry 0.600000 1.000 1.000

1307359001 13G Strawberry

- babyfood 0.600000 1.000 1.000

1307360000 13G Strawbe rry, juice 0.600000 1.000 1.000

1307360001 13G Strawberry, juice

- babyfood 0.600000 1.000 1.000

1500025000 15 Barley, pearled barley 0.600000 1.000 1.000

1500025001 15 Barley, pearled barley

- babyfood 0.600000 1.000 1.000

1500026000 15 Barley, flour 0.600000 1.000 1.000

1500026001 15 Barley, flour

- babyfood 0.600000 1.000 1.000

1500027000 15 Barley, bran 0.600000 1.000 1.00 0

1500065000 15 Buckwheat 0.600000 1.000 1.000

1500066000 15 Buckwheat, flour 0.600000 1.000 1.000

1500120000 15 Corn, field, flour 0.600000 1.000 1.000

1500120001 15 Corn, field, flour

- babyfood 0.600000 1.000 1.000

1500121000 15 Corn, field, meal 0.600000 1.000 1.000

1500121001 15 Corn, field, meal

- babyfood 0.600000 1.000 1.000

### Cyromazine (PC C ode 121301 ) Dietary Exposure and Risk Assessment DP #: 414945



## Page 13 of 23 1500122000 15 Corn, field, bran 0.600000 1.000 1.000

1500123000 15 Corn, field, starch 0.600000 1.000 1.000

1500123001 15 Corn, field, starch

- babyfood 0.600000 1.000 1.000

1500124000 15 Corn, field, syrup 0.600000 1.000 1.000

1500124001 15 Corn, field, syrup

- babyfood 0.600000 1.000 1.000

1500125000 15 Corn, field, oil 0.600000 1.000 1.000

1500125001 15 Corn, field, oil

- babyfood 0.600000 1.000 1.000

1500126000 15 C orn, pop 0.600000 1.000 1.000

1500127000 15 Corn, sweet 0.600000 1.000 1.000

1500127001 15 Corn, sweet

- babyfood 0.600000 1.000 1.000

1500226000 15 Millet, grain 0.600000 1.000 1.000

1500231000 15 Oat, bran 0.600000 1.000 1.000

1500232000 15 Oat, flour 0.600000 1.000 1.000

1500232001 15 Oat, flour

- babyfood 0.600000 1.000 1.000

1500233000 15 Oat, groats/rolled oats 0.600000 1.000 1.000

1500233001 15 Oat, groats/rolled oats

- babyfood 0.600000 1.000 1.000

1500323000 15 Rice, white 0.600000 1.000 1.000

1500323001 15 Rice, white

- babyfood 0.600000 1.000 1.000

1500324000 15 Rice, brown 0.600000 1.000 1.000

1500324001 15 Rice, brown

- babyfood 0.600000 1.000 1.000

1500325000 15 Rice, flour 0.600000 1.000 1.000

1500325001 15 Rice, flour

- babyfood 0.600000 1.000 1.000

1500326000 15 Rice, bran 0.600000 1.000 1.000

1500326001 15 Rice, bran

- babyfood 0.600000 1.0 00 1.000

1500328000 15 Rye, grain 0.600000 1.000 1.000

1500329000 15 Rye, flour 0.600000 1.000 1.000

1500344000 15 Sorghum, grain 0.600000 1.000 1.000

1500345000 15 Sorghum, syrup 0.600000 1.000 1.000

1500381000 15 Triticale, flour 0.600000 1.000 1.000

1500381001 15 Triticale, flour

- babyfood 0.600000 1.000 1.000

1500401000 15 Wheat, grain 0.600000 1.000 1.000

1500401001 15 Wheat, grain

- babyfood 0.600000 1.000 1.000

1500402000 15 Wheat, flour 0.600000 1.000 1.000

1500402001 15 Wheat, flour

- babyfood 0.600000 1.000 1.000

1500403000 15 Wheat, germ 0.600000 1.000 1.000

1500404000 15 Wheat, bran 0.600000 1.000 1.000

1500405000 15 Wild rice 0.600000 1.000 1.000

1800002000 18 Alfalfa, seed 0.600000 1.000 1.000

1901028000 19A Basil, fresh leaves 0.600000 1.000 1.000

1901028001 19A Basil, fresh leaves

- babyfood 0.600000 1.000 1.000

1901029000 19A Basil, dried leaves 0.600000 1.000 1.000

1901029001 19A Basil, dried leaves

- babyfood 0.600000 1.000 1.000

1901102500 19A Chive, dried leaves 0.600000 1.000 1.000

1901118000 19A Cilantro, leaves 0.600000 1.000 1.000

1901118001 19A Cilantro, leaves

- babyfood 0.600000 1.000 1.000

1901144000 19A Dillweed 0.600000 1.000 1.000

1901184000 19A Herbs, other 0.600000 1.000 1.000

19011840 01 19A Herbs, other

- babyfood 0.600000 1.000 1.000

1901202000 19A Lemongrass 0.600000 1.000 1.000

1901220000 19A Marjoram 0.600000 1.000 1.000

1901220001 19A Marjoram

- babyfood 0.600000 1.000 1.000

1901249000 19A Parsley, dried leaves 0.600000 1.000 1.000

1901249001 19A Parsley, dried leaves

- babyfood 0.600000 1.000 1.000

1901334000 19A Savory 0.60000 0 1.000 1.000

1902105000 19B Cinnamon 0.600000 1.000 1.000

1902105001 19B Cinnamon

- babyfood 0.600000 1.000 1.000

1902119000 19B Coriander, seed 0.600000 1.000 1.000

190211 9001 19B Coriander, seed

- babyfood 0.600000 1.000 1.000

1902143000 19B Dill, seed 0.600000 1.000 1.000

1902274000 19B Pepper, black and white 0.600000 1.000 1.000

1902274001 19B Pepper, black a nd white

- babyfood 0.600000 1.000 1.000

1902354000 19B Spices, other 0.600000 1.000 1.000

1902354001 19B Spices, other

- babyfood 0.600000 1.000 1.000

2001163000 20A Flax seed, oil 0.600000 1.000 1.000

2001319000 20A Rapeseed, oil 0.600000 1.000 1.000

2001319001 20A Rapeseed, oil

- babyfood 0.600000 1.000 1.000

2001336000 20A Sesame, seed 0.600000 1.000 1.000

### Cyromazine (PC C ode 121301 ) Dietary Exposure and Risk Assessment DP #: 414945



## Page 14 of 23 2001336001 20A Sesame, seed

- babyfood 0.600000 1.000 1.000

2001337000 20A Sesame, oil 0.600000 1.000 1.000

2001337001 20A Sesame, oil

- babyfood 0.600000 1.000 1 .000

2002330000 20B Safflower, oil 0.600000 1.000 1.000

2002330001 20B Safflower, oil

- babyfood 0.600000 1.000 1.000

2002364000 20B Sunflower, seed 0.600000 1.000 1.000

2002365000 20B Su nflower, oil 0.600000 1.000 1.000

2002365001 20B Sunflower, oil

- babyfood 0.600000 1.000 1.000

2003114001 20C Coconut, oil

- babyfood 0.600000 1.000 1.000

2003128000 20C Cottonseed, oil 0.600000 1.000 1.000

2003128001 20C Cottonseed, oil

- babyfood 0.600000 1.000 1.000

2100228000 21 Mushroom 8.000000 1.000 1.000

3100044000 31 Beef, meat 0.300000 1.000 1.000

3100044001 31 Beef, meat

- babyfood 0.300000 1.000 1.000

3100045000 31 Beef, meat, dried 0.300000 1.920 1.000

3100046000 31 Beef, meat byproducts 0.300000 1.000 1.000

3100046001 31 Beef, meat byproducts

- babyfood 0.300000 1.000 1.000

3100047000 31 Beef, fat 0.050000 1.000 1.000

3100047001 31 Beef, fat

- babyfood 0.050000 1.000 1.000

3100048000 31 Beef, kidney 0.300000 1.000 1.000

3100049000 31 Beef, liver 0.300000 1.000 1.000

3100049001 31 Beef, liver

- babyfood 0.300000 1.000 1.000

3200169000 32 Goat, meat 0.300000 1.00 0 1.000

3200170000 32 Goat, meat byproducts 0.300000 1.000 1.000

3200171000 32 Goat, fat 0.050000 1.000 1.000

3200172000 32 Goat, kidney 0.300000 1.000 1.000

3200173000 32 Goat, liver 0.300000 1.000 1.000

3300189000 33 Horse, meat 0.300000 1.000 1.000

3400290000 34 Pork, meat 0.300000 1.000 1.000

3400290001 34 Pork, mea t

- babyfood 0.300000 1.000 1.000

3400291000 34 Pork, skin 0.050000 1.000 1.000

3400292000 34 Pork, meat byproducts 0.300000 1.000 1.000

3400292001 34 Pork, meat byproducts

- babyfood 0.300000 1.000 1.000

3400293000 34 Pork, fat 0.050000 1.000 1.000

3400293001 34 Pork, fat

- babyfood 0.050000 1.000 1.000

3400294000 34 Pork, kidney 0.300000 1.000 1.000

3400295000 34 Pork, liver 0.300000 1.000 1.000

3500339000 35 Sheep, meat 0.300000 1.000 1.000

3500339001 35 Sheep, meat

- babyfood 0.300000 1.000 1.000

3500340000 35 Sheep, meat byproducts 0.300000 1.000 1.000

3500341000 35 Sheep, fat 0.050000 1.000 1.000

3500341001 35 Sheep, fat

- babyfood 0.050000 1.000 1.000

3500342000 35 Sheep, kidney 0.300000 1.000 1.000

3500343000 35 Sheep, liver 0.300000 1.000 1.000

3600222000 36 Milk, fat 0.100000 1.000 1.000

3600222001 36 Milk, fat

- baby food/infant formu 0.100000 1.000 1.00 0

3600223000 36 Milk, nonfat solids 0.100000 1.000 1.000

3600223001 36 Milk, nonfat solids

- baby food/in 0.100000 1.000 1.000

3600224000 36 Milk, water 0.100000 1.000 1.000

3600224001 36 Milk, water

- babyfood/infant form 0.100000 1.000 1.000

3600225001 36 Milk, sugar (lactose)

- baby food/ 0.100000 1.000 1.000

3800221000 38 Meat, game 0.300000 1.000 1.000

3900312000 39 Rabbit, meat 0.300000 1.000 1.000

4000093000 40 Chicken, meat 0.100000 1.000 1.000

4000093001 40 Chicken, meat

- babyfood 0.100000 1.000 1.000

4000094000 40 Chicken, liver 0.200000 1.000 1.000

4000095000 40 Chicken, meat byproducts 0.200000 1.000 1.000

4000095001 40 Chicken, meat byproducts

- babyfoo 0.200000 1.000 1.000

4000096000 40 Chicken, fat 0.200000 1.000 1.000

4000096001 40 Chicken, fat

- babyfood 0.200000 1.000 1.000

4000097000 40 Chicken, skin 0.200000 1.000 1.000

4000097001 40 Chicken, skin

- babyfood 0.200000 1.000 1.000

5000382000 50 Turkey, meat 0.100000 1.000 1.000

5000382001 50 Turkey, meat

- babyfood 0.100000 1.000 1.000

5000383000 50 Turkey, liver 0.200000 1.000 1.000

5000383001 50 Turkey, liver

- babyfood 0.200000 1.000 1.000

5000384000 50 Turkey, meat byproducts 0.200000 1.000 1.000

### Cyromazine (PC C ode 121301 ) Dietary Exposure and Risk Assessment DP #: 414945



## Page 15 of 23 5000384001 50 Turkey, meat byproducts

- babyfood 0.200000 1.000 1.000

5000385000 50 Turkey, fat 0.200000 1.000 1.000

5000385001 50 Turkey, fat

- babyfood 0.200000 1.000 1.000

5000386000 50 Turkey, skin 0.200000 1.000 1.000

5000386001 50 Turkey, skin

- babyfood 0.200000 1.000 1.00 0

6000301000 60 Poultry, other, meat 0.100000 1.000 1.000

6000302000 60 Poultry, other, liver 0.200000 1.000 1.000

6000303000 60 Poultry, other, meat byproducts 0.200000 1.000 1.000

6000304000 60 Poult ry, other, fat 0.200000 1.000 1.000

6000305000 60 Poultry, other, skin 0.200000 1.000 1.000

7000145000 70 Egg, whole 0.300000 1.000 1.000

7000145001 70 Egg, whole

- babyfood 0.300000 1.000 1.000

7000146000 70 Egg, white 0.300000 1.000 1.000

7000146001 70 Egg, white (solids)

- babyfood 0.300000 1.000 1.000

7000147000 70 Egg, yolk 0.300000 1.000 1.000

7000147001 70 Egg, yolk

- babyfood 0.300000 1.000 1.000

8601000000 86A Water, direct, all sources 0.111000 1.000 1.000 PRZM G

Full comment: PRZM GW

8602000000 86B Water, indirect, all sources 0.1 11000 1.000 1.000 PRZM G

Full comment: PRZM GW

9500001000 O Acerola 0.600000 1.000 1.000

9500006000 O Amaranth, grain 0.600000 1.000 1.000

9500016000 O Artichoke, globe 0.600000 1.000 1.000

9500019000 O Asparagus 0.600000 1.000 1.000

9500054000 O Belgium endive 0.600000 1.000 1.000

9500215000 O Mango 0.500000 1. 000 1.000

9500215001 O Mango

- babyfood 0.500000 1.000 1.000

9500216000 O Mango, dried 0.500000 1.000 1.000

9500217000 O Mango, juice 0.500000 1.000 1.000

9500217001 O Mango, juice

- babyfood 0.500000 1.000 1.000

9500263000 O Peanut 0.600000 1.890 1.000

9500264000 O Peanut, butter 0.600000 1.000 1.000

9500265000 O Peanut, oil 0.600000 1.000 1.000

9500306000 O Psyllium, seed 0.600000 1.000 1.000

9500311000 O Quinoa, grain 0.600000 1.000 1.000

Filename: C: \ Documents and Settings \ tmorton \ My Documents \ My Files \ DEEM Files \ 121301 Cyromazine \ Reg

Review Risk Assessment \ 121301 Chronic Tolerance Updated Water.R08

Chemical: cyromazine

RfD(Chronic): .5 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .83 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date creat ed/last modified: 12

- 03

- 2013/12:38:17 Program ver. 3.16, 03

- 08

- d

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment

Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0101050000 1AB Beet, garden, roots 0.600000 1.000 1.000

0101050001 1AB Beet, garden, roots

- babyfood 0.600000 1.000 1.000

0101052000 1A Beet, sugar 0.600000 1.000 1.000

0101052001 1A Beet, sugar

- babyfood 0.600000 1.000 1.000

0101053000 1A Beet, sugar, molasses 0.600000 1.000 1.000

0101053001 1A Beet, sugar, molasses

- babyfood 0.600000 1.000 1.000

0101067000 1AB Burdock 0.600000 1.000 1.000

0101078000 1AB Carrot 0.600000 1.000 1.000

01010780 01 1AB Carrot

- babyfood 0.600000 1.000 1.000

0101079000 1AB Carrot, juice 0.600000 1.000 1.000

0101084000 1AB Celeriac 0.600000 1.000 1.000

0101100000 1AB Chicory, roots 0.600000 1.000 1.000

0101168000 1AB Ginseng, dried 0.600000 1.000 1.000

0101190000 1AB Horseradish 0.600000 1.000 1.000

0101250000 1AB Parsley, turnip rooted 0.60000 0 1.000 1.000

0101251000 1AB Parsnip 0.600000 1.000 1.000

0101251001 1AB Parsnip

- babyfood 0.600000 1.000 1.000

0101314000 1AB Radish, roots 0.600000 1.000 1.000

010131 6000 1AB Radish, Oriental, roots 0.600000 1.000 1.000

### Cyromazine (PC C ode 121301 ) Dietary Exposure and Risk Assessment DP #: 414945



## Page 16 of 23 0101327000 1AB Rutabaga 0.600000 1.000 1.000

0101331000 1AB Salsify, roots 0.600000 1.000 1.000

0101388000 1AB Turnip, roots 0.600000 1.000 1.000

0103015000 1CD Arrowroot, flour 0.600000 1.000 1.000

0103015001 1CD Arrowroot, flour

- babyfood 0.600000 1.000 1.000

0103017000 1CD Artichoke, Jerusalem 0.600 000 1.000 1.000

0103082000 1CD Cassava 0.600000 1.000 1.000

0103082001 1CD Cassava

- babyfood 0.600000 1.000 1.000

0103139000 1CD Dasheen, corm 0.600000 1.000 1.000

0103166000 1CD Ginger 0.600000 1.000 1.000

0103166001 1CD Ginger

- babyfood 0.600000 1.000 1.000

0103167000 1CD Ginger, dried 0.600000 1.000 1.000

0103296000 1C Potato, c hips 0.800000 1.900 1.000 Highes

Full comment: Highest residue in 1x studies

0103297000 1C Potato, dry (granules/ flakes) 0.800000 2.600 1.000

0103297001 1C Potato, dry (granules/ flakes)

- b 0.800000 2.6 00 1.000

0103298000 1C Potato, flour 0.800000 2.600 1.000

0103298001 1C Potato, flour

- babyfood 0.800000 2.600 1.000

0103299000 1C Potato, tuber, w/peel 0.800000 1.000 1.000

0103299001 1C Potato, tuber, w/peel

- babyfood 0.800000 1.000 1.000

0103300000 1C Potato, tuber, w/o peel 0.800000 1.000 1.000

0103300001 1C Potato, tuber, w/o peel

- babyfood 0.800000 1.000 1.000

0103366000 1CD Sweet potato 0.600000 1.000 1.000

0103366001 1CD Sweet potato

- babyfood 0.600000 1.000 1.000

0103371000 1CD Tanier, corm 0.600000 1.000 1.000

0103387000 1CD Turmeric 0.600000 1 .000 1.000

0103406000 1CD Yam, true 0.600000 1.000 1.000

0103407000 1CD Yam bean 0.600000 1.000 1.000

0200051000 2 Beet, garden, tops 0.600000 1.000 1.000

0200101000 2 Chicory, tops 0.600000 1.000 1.000

0200140000 2 Dasheen, leaves 0.600000 1.000 1.000

0200315000 2 Radish, tops 0.600000 1.000 1.000

0200317000 2 Radish, Oriental, to ps 0.600000 1.000 1.000

0200332000 2 Salsify, tops 0.600000 1.000 1.000

0301165000 3A Garlic, bulb 0.600000 1.000 1.000

0301165001 3A Garlic, bulb

- babyfood 0.600000 1.000 1.000

0301237000 3A Onion, bulb 0.600000 1.000 1.000

0301237001 3A Onion, bulb

- babyfood 0.600000 1.000 1.000

0301238000 3A Onion, bulb, dried 0.600000 9.000 1.000

0301238001 3A Onion, bulb, dried

- babyfood 0.600000 9.000 1.000

0301338000 3A Shallot, bulb 0.600000 1.000 1.000

0302103000 3B Chive, fresh leaves 0.600000 1.000 1.000

0302198000 3B Leek 3.000000 1.000 1.000 Highes

Full comment: Highest Residue

0302239000 3B Onion, green 3.000000 1.000 1.000

0302338500 3B Shallot, fresh leaves 0.600000 1. 000 1.000

0401005000 4A Amaranth, leafy 10.000000 1.000 1.000

0401018000 4A Arugula 10.000000 1.000 1.000

0401104000 4A Chrysanthemum, garland 10.000000 1.000 1.000

0401133000 4 A Cress, garden 10.000000 1.000 1.000

0401134000 4A Cress, upland 10.000000 1.000 1.000

0401138000 4A Dandelion, leaves 10.000000 1.000 1.000

0401150000 4A Endive 10.000000 1.000 1.000

0401204000 4A Lettuce, head 10.000000 1.000 1.000

0401205000 4A Lettuce, leaf 10.000000 1.000 1.000

0401248000 4A Parsley, leaves 10.000000 1.000 1.000

0401313000 4A Radicchio 10.000000 1.000 1.000

0401355000 4A Spinach 10.000000 1.000 1.000

0401355001 4A Spinach

- babyfood 10.000000 1.000 1.000

0402076000 4B Cardoon 10.000000 1.000 1.000

0402085000 4B Celery 10.000000 1.000 1.000

0402085001 4B Celery

- babyfood 10.000000 1.000 1.000

0402086000 4B Celery, juice 10.000000 1.000 1.000

0402087000 4B Celtuce 10.000000 1.000 1.000

0402152000 4B Fennel, Florence 10.000000 1.000 1.000

0402322000 4B Rhubarb 10.000000 1.000 1.000

0402367000 4B Swiss chard 10.000000 1.000 1.000

### Cyromazine (PC C ode 121301 ) Dietary Exposure and Risk Assessment DP #: 414945



## Page 17 of 23 0501061000 5A Broccoli 35.000000 1.000 1.000

0501061001 5A Broccoli

- babyfood 35.000000 1.000 1.000

0501062000 5A Broccoli, Chinese 35.000000 1.000 1.000

0501064000 5A Brussels sprouts 35.000000 1.000 1.000

0501069000 5A Cabbage 35.000000 1.000 1.000

0501071000 5A Cabbage, Chinese, napa 35.000000 1.000 1.000

0501072000 5A Cabbage, Chinese, mustard 35.000000 1.000 1.000

0501083000 5A Cauliflower 35.000000 1.000 1.000

0501196000 5A Kohlrabi 35.000000 1.000 1.000

0502063000 5B Broccoli raab 35.000000 1.000 1.000

0502070000 5B Cabbage, Chinese, bok choy 35.000000 1.000 1.000

0502117000 5B Collard s 35.000000 1.000 1.000

0502194000 5B Kale 35.000000 1.000 1.000

0502229000 5B Mustard greens 35.000000 1.000 1.000

0502318000 5B Rape greens 35.000000 1.000 1.000

0502389000 5B Turnip, greens 35.000000 1.000 1.000

0600347000 6 Soybean, seed 0.600000 1.000 1.000

0600349000 6 Soybean, soy milk 0.600000 1.000 1.00 0

0600349001 6 Soybean, soy milk

- babyfood or in 0.600000 1.000 1.000

0600350000 6 Soybean, oil 0.600000 1.000 1.000

0600350001 6 Soybean, oil

- babyfood 0.600000 1.000 1.000

0601043000 6A Bean, snap, succulent 2.000000 1.000 1.000 Highes

Full comment: Highest FT residue

0601043001 6A Bean, snap, succulent

- babyfood 2.000000 1.000 1.000

0601257000 6A Pea, edible podded, succulent 2.000000 1.000 1.0 00

0601349500 6AB Soybean, vegetable 2.000000 1.000 1.000

0602031000 6B Bean, broad, succulent 2.000000 1.000 1.000

0602033000 6B Bean, cowpea, succulent 2.000000 1.000 1.000

0602037000 6B Bean, lima, succulent 1.000000 1.000 1.000

0602255000 6B Pea, succulent 2.000000 1.000 1.000

0602255001 6B Pea, succulent

- babyfood 2.000000 1.000 1.000

0602259000 6B Pea, pige on, succulent 2.000000 1.000 1.000

0603030000 6C Bean, black, seed 3.000000 1.000 1.000

0603032000 6C Bean, broad, seed 3.000000 1.000 1.000

0603034000 6C Bean, cowpea, seed 3.000000 1.000 1.000

0603035000 6C Bean, great northern, seed 3.000000 1.000 1.000

0603036000 6C Bean, kidney, seed 3.000000 1.000 1.000

0603038000 6C Bean, lima, seed 3.000000 1.000 1.000

0603039000 6C Bean, mung, seed 3.000000 1.000 1.000

0603040000 6C Bean, navy, seed 3.000000 1.000 1.000

0603041000 6C Bean, pink, seed 3.000000 1.000 1.000

0603042000 6C Bean, p into, seed 3.000000 1.000 1.000

0603098000 6C Chickpea, seed 3.000000 1.000 1.000

0603098001 6C Chickpea, seed

- babyfood 3.000000 1.000 1.000

0603099000 6C Chickpea, flour 3.000000 1.000 1.000

0603182000 6C Guar, seed 3.000000 1.000 1.000

0603182001 6C Guar, seed

- babyfood 3.000000 1.000 1.000

0603203000 6C Lentil, seed 3.000000 1.000 1.00 0

0603256000 6C Pea, dry 3.000000 1.000 1.000

0603256001 6C Pea, dry

- babyfood 3.000000 1.000 1.000

0603258000 6C Pea, pigeon, seed 3.000000 1.000 1.000

0603348000 6C Soybe an, flour 0.600000 1.000 1.000

0603348001 6C Soybean, flour

- babyfood 0.600000 1.000 1.000

0801374000 8A Tomatillo 1.000000 1.000 1.000

0801375000 8A Tomato 1.000000 1.000 1.000

0801375001 8A Tomato

- babyfood 1.000000 1.000 1.000

0801376000 8A Tomato, paste 1.000000 1.000 1.000 tolera

Full comment: tolerance will cover paste and puree

0801376001 8A Tomato, paste

- babyfood 1.000000 1.000 1.000

0801377000 8A Tomato, puree 1.000000 1.000 1.000

0801377001 8A Tomato, puree

- babyfood 1.000000 1.000 1.000

0801378000 8A Tomato, d ried 1.000000 2.400 1.000

0801378001 8A Tomato, dried

- babyfood 1.000000 2.400 1.000

0801379000 8A Tomato, juice 1.000000 1.500 1.000

0801380000 8A Tomato, Tree 1.000000 1.000 1.000

0802148000 8BC Eggplant 0.600000 1.000 1.000

0802234000 8BC Okra 0.600000 1.000 1.000

### Cyromazine (PC C ode 121301 ) Dietary Exposure and Risk Assessment DP #: 414945



## Page 18 of 23 0802270000 8B Pepper, bell 3.000000 1.000 1.000

0802270001 8B Pepper, bell

- babyfood 3.000000 1.000 1.000

0802271000 8B Pepper, bell, dried 3.000000 1.000 1.000

0802271001 8B Pepper, bell, dried

- babyfood 3.000000 1.000 1.000

0802272000 8BC Pepper, nonbell 3.000000 1.000 1.000

0802272001 8BC Pepper, nonbell

- babyfood 3.000000 1.000 1.000

0802273000 8BC Pepper, nonbell, dried 3.000000 1.000 1.000

0901075000 9A Cantaloupe 2.000000 1.000 1.000

0901187000 9A Honeydew melon 2.000000 1.000 1.000

0901399000 9A Watermelon 2.000000 1.000 1.000

0901400000 9A Watermelon, juice 2.000000 1.000 1.00 0

0902021000 9B Balsam pear 2.000000 1.000 1.000

0902088000 9B Chayote, fruit 2.000000 1.000 1.000

0902102000 9B Chinese waxgourd 2.000000 1.000 1.000

0902135000 9B Cucum ber 2.000000 1.000 1.000

0902308000 9B Pumpkin 2.000000 1.000 1.000

0902309000 9B Pumpkin, seed 2.000000 1.000 1.000

0902356000 9B Squash, summer 2.000000 1.000 1.000

0902356001 9B Squash, summer

- babyfood 2.000000 1.000 1.000

0902357000 9B Squash, winter 2.000000 1.000 1.000

0902357001 9B Squash, w inter

- babyfood 2.000000 1.000 1.000

1307359000 13G Strawberry 0.600000 1.000 1.000

1307359001 13G Strawberry

- babyfood 0.600000 1.000 1.000

1307360000 13G Strawberry, juice 0.600000 1.000 1.000

1307360001 13G Strawberry, juice

- babyfood 0.600000 1.000 1.000

1500025000 15 Barley, pearled barley 0.600000 1.000 1.000

1500025001 15 Barley, pearled barley

- babyfood 0.600000 1.000 1.000

1500026000 15 Barley, flour 0.600000 1.000 1.000

1500026001 15 Barley, flour

- babyfood 0.600000 1.000 1.000

1500027000 15 Barley, bran 0.600000 1.000 1.000

1500065000 15 Buckwhe at 0.600000 1.000 1.000

1500066000 15 Buckwheat, flour 0.600000 1.000 1.000

1500120000 15 Corn, field, flour 0.600000 1.000 1.000

1500120001 15 Corn, field, flour

- babyfood 0.600000 1.000 1.000

1500121000 15 Corn, field, meal 0.600000 1.000 1.000

1500121001 15 Corn, field, meal

- babyfood 0.600000 1.000 1.000

1500122000 15 Corn, field, bran 0.600000 1.000 1.00 0

1500123000 15 Corn, field, starch 0.600000 1.000 1.000

1500123001 15 Corn, field, starch

- babyfood 0.600000 1.000 1.000

1500124000 15 Corn, field, syrup 0.600000 1.000 1.000

1500124001 15 Corn, field, syrup

- babyfood 0.600000 1.000 1.000

1500125000 15 Corn, field, oil 0.600000 1.000 1.000

1500125001 15 Corn, field, oil

- babyfood 0.600000 1.000 1.000

1500126000 15 Corn, pop 0.600000 1.000 1.000

1500127000 15 Corn, sweet 0.600000 1.000 1.000

1500127001 15 Corn, sweet

- babyfood 0.600000 1.000 1.000

1500226000 15 Millet, grain 0.600000 1.000 1.000

1500231000 15 Oat, bran 0.600000 1.000 1.000

1500232000 15 Oat, flour 0.600000 1.000 1.000

1500232001 15 Oat, flour

- babyfood 0.600000 1.000 1.000

1500233000 15 O at, groats/rolled oats 0.600000 1.000 1.000

1500233001 15 Oat, groats/rolled oats

- babyfood 0.600000 1.000 1.000

1500323000 15 Rice, white 0.600000 1.000 1.000

1500323001 15 Rice, white

- babyfood 0.600000 1.000 1.000

1500324000 15 Rice, brown 0.600000 1.000 1.000

1500324001 15 Rice, brown

- babyfood 0.600000 1.000 1.000

1500325000 15 Rice, flour 0.600000 1.000 1.000

1500325001 15 Rice, flour

- babyfood 0.600000 1.000 1.000

1500326000 15 Rice, bran 0.600000 1.000 1.000

1500326001 15 Rice, bran

- babyfood 0.600000 1.000 1.000

1500328000 15 Rye, grain 0.600000 1.000 1.000

1500329000 15 Rye, flour 0.600000 1.000 1.000

1500344000 15 Sorghum, grain 0.600000 1.000 1.000

1500345000 15 Sorghum, syrup 0.600000 1.000 1.000

1500381000 15 Triticale, flour 0.600000 1.000 1.000

1500381001 15 Triticale, flour

- babyfood 0.600000 1.000 1.000

1500401000 15 Wheat, grain 0.600000 1.0 00 1.000

### Cyromazine (PC C ode 121301 ) Dietary Exposure and Risk Assessment DP #: 414945



## Page 19 of 23 1500401001 15 Wheat, grain

- babyfood 0.600000 1.000 1.000

1500402000 15 Wheat, flour 0.600000 1.000 1.000

1500402001 15 Wheat, flour

- babyfood 0.600000 1.000 1.000

1500403000 15 Wheat, germ 0.600000 1.000 1.000

1500404000 15 Wheat, bran 0.600000 1.000 1.000

1500405000 15 Wild rice 0.600000 1.000 1.000

1800002000 18 Alfalfa, seed 0.600000 1.000 1.000

1901028000 19A Basil, fresh leaves 0.600000 1.000 1.000

1901028001 19A Basil, fresh leaves

- babyfood 0.600000 1.000 1.000

1901029000 19A Basil , dried leaves 0.600000 1.000 1.000

1901029001 19A Basil, dried leaves

- babyfood 0.600000 1.000 1.000

1901102500 19A Chive, dried leaves 0.600000 1.000 1.000

1901118000 19A Cilantro, leaves 0.600000 1.000 1.000

1901118001 19A Cilantro, leaves

- babyfood 0.600000 1.000 1.000

1901144000 19A Dillweed 0.600000 1.000 1.000

1901184000 19A Herbs, other 0.600000 1.000 1. 000

1901184001 19A Herbs, other

- babyfood 0.600000 1.000 1.000

1901202000 19A Lemongrass 0.600000 1.000 1.000

1901220000 19A Marjoram 0.600000 1.000 1.000

1901220001 19A Mar joram

- babyfood 0.600000 1.000 1.000

1901249000 19A Parsley, dried leaves 0.600000 1.000 1.000

1901249001 19A Parsley, dried leaves

- babyfood 0.600000 1.000 1.000

1901334000 19A Savory 0.600000 1.000 1.000

1902105000 19B Cinnamon 0.600000 1.000 1.000

1902105001 19B Cinnamon

- babyfood 0.600000 1.000 1.000

1902119000 19B Coriander, seed 0.600000 1.000 1.000

1902119001 19B Coriander, seed

- babyfood 0.600000 1.000 1.000

1902143000 19B Dill, seed 0.600000 1.000 1.000

1902274000 19B Pepper, black and white 0.600000 1.000 1.000

1902274001 19B P epper, black and white

- babyfood 0.600000 1.000 1.000

1902354000 19B Spices, other 0.600000 1.000 1.000

1902354001 19B Spices, other

- babyfood 0.600000 1.000 1.000

2001163000 20A Flax seed, oil 0.600000 1.000 1.000

2001319000 20A Rapeseed, oil 0.600000 1.000 1.000

2001319001 20A Rapeseed, oil

- babyfood 0.600000 1.000 1.000

2001336000 20A Sesame, seed 0.600000 1.000 1.000

2001336001 20A Sesame, seed

- babyfood 0.600000 1.000 1.000

2001337000 20A Sesame, oil 0.600000 1.000 1.000

2001337001 20A Sesame, oil

- babyfood 0.600000 1.000 1.000

2002330000 20B Safflower, oil 0.600000 1.000 1.000

2002330001 20B Safflower, oil

- babyfood 0.600000 1.000 1.000

2002364000 20B Sunflower, seed 0.600000 1.000 1.000

2002365000 20B Sunflower, oil 0.600000 1.000 1.000

2002365001 20B Sunflower, oil

- babyfood 0.600000 1.000 1.000

2003114001 20C Coconut, oil

- babyfood 0.600000 1.000 1.000

2003128000 20C Cottonseed, oil 0.600000 1.0 00 1.000

2003128001 20C Cottonseed, oil

- babyfood 0.600000 1.000 1.000

2100228000 21 Mushroom 8.000000 1.000 1.000

3100044000 31 Beef, meat 0.300000 1.000 1.000

3100044001 31 Beef, meat

- babyfood 0.300000 1.000 1.000

3100045000 31 Beef, meat, dried 0.300000 1.920 1.000

3100046000 31 Beef, meat byproducts 0.300000 1.000 1.000

3100046001 31 Beef, meat byproducts

- babyfood 0.300000 1.000 1.000

3100047000 31 Beef, fat 0.050000 1.000 1.000

3100047001 31 Beef, fat

- babyfood 0.050000 1.000 1.000

3100048000 31 Beef, kidney 0.300000 1 .000 1.000

3100049000 31 Beef, liver 0.300000 1.000 1.000

3100049001 31 Beef, liver

- babyfood 0.300000 1.000 1.000

3200169000 32 Goat, meat 0.300000 1.000 1.000

3200170000 32 Goat, meat byproducts 0.300000 1.000 1.000

3200171000 32 Goat, fat 0.050000 1.000 1.000

3200172000 32 Goat, kidney 0.300000 1.000 1.000

3200173000 32 Goat, liver 0.300000 1.000 1.000

3300189000 33 Horse, meat 0.300000 1.000 1.000

3400290000 34 Pork, meat 0.300000 1.000 1.000

3400290001 34 Pork, meat

- babyfood 0.300000 1.000 1.000

3400291000 34 Pork, skin 0.050000 1.000 1.000

### Cyromazine (PC C ode 121301 ) Dietary Exposure and Risk Assessment DP #: 414945



## Page 20 of 23 3400292000 34 Pork, meat byproducts 0.300000 1.000 1.000

3400292001 34 Pork, meat byproducts

- babyfood 0.300000 1.000 1.000

3400293000 34 Pork, fat 0.050000 1.000 1.000

3400293001 34 Pork, fat

- babyfood 0.050000 1.000 1.000

3400294000 34 Pork, kidney 0.300000 1.000 1.000

3400295000 34 Pork, liv er 0.300000 1.000 1.000

3500339000 35 Sheep, meat 0.300000 1.000 1.000

3500339001 35 Sheep, meat

- babyfood 0.300000 1.000 1.000

3500340000 35 Sheep, meat byproducts 0.300000 1.000 1.000

3500341000 35 Sheep, fat 0.050000 1.000 1.000

3500341001 35 Sheep, fat

- babyfood 0.050000 1.000 1.000

3500342000 35 Sheep, kidney 0.300000 1.000 1.000

3500343000 35 Sheep, liver 0.300000 1.000 1.000

3600222000 36 Milk, fat 0.100000 1.000 1.000

3600222001 36 Milk, fat

- baby food/infant formu 0.100000 1.000 1.000

3600223000 36 Milk, n onfat solids 0.100000 1.000 1.000

3600223001 36 Milk, nonfat solids

- baby food/in 0.100000 1.000 1.000

3600224000 36 Milk, water 0.100000 1.000 1.000

3600224001 36 Milk, water

- babyfood/infant form 0.100000 1.000 1.000

3600225001 36 Milk, sugar (lactose)

- baby food/ 0.100000 1.000 1.000

3800221000 38 Meat, game 0.300000 1.000 1.000

3900312000 39 Rabbit, meat 0.300000 1.000 1.00 0

4000093000 40 Chicken, meat 0.100000 1.000 1.000

4000093001 40 Chicken, meat

- babyfood 0.100000 1.000 1.000

4000094000 40 Chicken, liver 0.200000 1.000 1.000

4000095000 40 Chick en, meat byproducts 0.200000 1.000 1.000

4000095001 40 Chicken, meat byproducts

- babyfoo 0.200000 1.000 1.000

4000096000 40 Chicken, fat 0.200000 1.000 1.000

4000096001 40 Chicken, fat

- babyfood 0.200000 1.000 1.000

4000097000 40 Chicken, skin 0.200000 1.000 1.000

4000097001 40 Chicken, skin

- babyfood 0.200000 1.000 1.000

5000382000 50 Turkey, meat 0.100000 1.000 1.000

5000382001 50 Turkey, meat

- babyfood 0.100000 1.000 1.000

5000383000 50 Turkey, liver 0.200000 1.000 1.000

5000383001 50 Turkey, liver

- babyfood 0.200000 1.000 1.000

5000384000 50 Turkey, meat byproducts 0.200000 1.000 1.000

5000384001 50 Turkey, meat byproducts

- babyfood 0.200000 1.000 1.000

5000385000 50 Turkey, fat 0.200000 1.000 1.000

5000385001 50 Turkey, fat

- babyfoo d 0.200000 1.000 1.000

5000386000 50 Turkey, skin 0.200000 1.000 1.000

5000386001 50 Turkey, skin

- babyfood 0.200000 1.000 1.000

6000301000 60 Poultry, other, meat 0.100000 1.000 1.000

6000302000 60 Poultry, other, liver 0.200000 1.000 1.000

6000303000 60 Poultry, other, meat byproducts 0.200000 1.000 1.000

6000304000 60 Poultry, other, fat 0.200000 1.000 1.000

60003050 00 60 Poultry, other, skin 0.200000 1.000 1.000

7000145000 70 Egg, whole 0.300000 1.000 1.000

7000145001 70 Egg, whole

- babyfood 0.300000 1.000 1.000

7000146000 70 Egg, white 0.300000 1.000 1.000

7000146001 70 Egg, white (solids)

- babyfood 0.300000 1.000 1.000

7000147000 70 Egg, yolk 0.300000 1.000 1.000

7000147001 70 Egg, yolk

- babyfood 0.30000 0 1.000 1.000

8601000000 86A Water, direct, all sources 0.086100 1.000 1.000 PRZM G

Full comment: PRZM GW

8602000000 86B Water, indirect, all sources 0.086100 1.000 1.000 PRZM G

Full comment: PRZM GW

950 0001000 O Acerola 0.600000 1.000 1.000

9500006000 O Amaranth, grain 0.600000 1.000 1.000

9500016000 O Artichoke, globe 0.600000 1.000 1.000

9500019000 O Asparagus 0.600000 1.000 1.000

9500054000 O Belgium endive 0.600000 1.000 1.000

9500215000 O Mango 0.500000 1.000 1.000

9500215001 O Mango

- bab yfood 0.500000 1.000 1.000

9500216000 O Mango, dried 0.500000 1.000 1.000

9500217000 O Mango, juice 0.500000 1.000 1.000

9500217001 O Mango, juice

- babyfood 0.500000 1.000 1.000

9500263000 O Peanut 0.600000 1.890 1.000

### Cyromazine (PC C ode 121301 ) Dietary Exposure and Risk Assessment DP #: 414945



## Page 21 of 23 9500264000 O Peanut, butter 0.600000 1.000 1.000

9500265000 O Peanut, oil 0.600000 1.000 1.000

9500306000 O Psyllium, seed 0.600000 1.000 1.000

9500311000 O Quinoa, grain 0.600000 1.000 1.000

### Cyromazine (PC C ode 121301 ) Dietary Exposure and Risk Assessment DP #: 414945



## Page 22 of 23 Attachment 2 Results of Acute DEEM

- FCID Dietary Exposure Analysis

U.S. EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for CYROMAZINE NHANES 2003

- 2008 2

- Day

Residue file: 121301 Acute Tolerance Updated Water.R08

Adjustment factor #2 NOT used.

Analysis Date: 01

- 09

- 2014/14:37:16 Res idue file dated: 01

- 09

- 2014/14:33:13

RAC/FF intake summed over 24 hours

Run Comment: ""

===============================================================================

Summary calculations

-- per capita:

95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- -------- Total US Populatio n:

0.063037 7.59 0.130393 15.71 0.311820 37.57

All Infants:

0.054077 6.52 0.142724 17.20 0.373097 44.95

Children 1

- 2:

0.148758 17.92 0.356593 42.96 0. 508735 61.29

Children 3

- 5:

0.102108 12.30 0.231196 27.85 0.643685 77.55

Children 6

- 12:

0.061079 7.36 0.168077 20.25 0.331486 39.94

Youth 13

- 19:

0.041088 4. 95 0.101439 12.22 0.192826 23.23

Adults 20

- 49:

0.057766 6.96 0.112857 13.60 0.275902 33.24

Adults 50

- 99:

0.067807 8.17 0.123034 14.82 0.199273 24.01

Female 13

- 49:

0.059258 7.14 0.118453 14.27 0.275611 33.21

### Cyromazine (PC C ode 121301 ) Dietary Exposure and Risk Assessment DP #: 414945



## Page 23 of 23 Attachment 2 Results of Chronic DEEM

- FCID Dietary Exposure Analysis

U.S. EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID Chronic analysis for CYROMAZINE NHANES 2003

- 2008 2

- day

Residue file name: C: \ Documents and Settings \ tmorton \ My Documents \ MyFiles \ DEEM Files \ 121301

Cyromazine \ Reg Review Risk Assessment \ 121301 Chronic Tolerance Updated Wat er.R08

Adjustment factor #2 used.

Analysis Date 01

- 09

- 2014/14:35:53 Residue file dated: 01

- 09

- 2014/14:34:38

Reference dose (RfD, Chronic) = .5 mg/kg bw/day

=========================================== ====================================

Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Percent of

Subgroup body wt/day Rfd

-------------------------------------- ------------- ---------------- Total US Population 0.019165 3.8%

Hispanic 0.018007 3.6%

Non

- Hisp

- White 0.018995 3.8%

Non

- Hisp

- Black 0.018806 3.8%

Non

- Hisp

- Other 0.025364 5.1%

Nursing Infants 0.013508 2.7%

Non

- Nursing Infants 0.024583 4.9%

Female 13+ PREG 0.016341 3.3%

Children 1

- 6 0.035138 7.0%

Children 7

- 12 0.019727 3.9%

Male 13

- 19 0.013650 2.7%

Female 13

- 19/NP 0.013714 2.7%

Male 20+ 0.016828 3.4%

Female 20+/NP 0.019130 3.8%

Seniors 55+ 0.018893 3.8%

All Infants 0.021164 4.2%

Female 13

- 50 0.017331 3.5%

Children 1

- 2 0.041309 8.3%

Children 3

- 5 0.032854 6.6%

Children 6

- 12 0.021037 4.2%

Youth 13

- 19 0.013667 2.7%

Adults 20

- 49 0.017346 3.5%

Adults 50

- 99 0.018921 3.8%

Female 13

- 49 0.0173 74 3.5%

-------------------------------------------------------------------------------