UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460 

## SEP 21 2011

OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION MEMORANDUM
SUBJECT: BEAD Chemical Profile for Registration Review: Cyprodinil (288202) FROM:

THRU:

TO: Tara Chandgoyal, Ph. D., Plant Pathologist Biological Analysis Branch CynthiaDoucoure, Environmental Protection Specialist 

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### ~ Science Information and Analysis Branch Andrew Lee, Economist 

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- Economic Analysis Branch

## ~ Biological and Economic Analysis Division (7503 ) Arnet Jones, Chief Biological·Analysis Branch 

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Diann Sims, Chief

# ,;{2**/7_JL~~--r­** Science Information and Analysis Branch Timothy Kiely, Chief

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Economic Analysis Branch ' Vv**~** Biological and Economic Analys Division (7 3P) WilhelmenaLivingston, Chemical ReviewManager Risk Management and ImplementationBranch4 Pesticide Re-evaluation Division (7508P)


### Product Review Panel date: September 14,2011 INTRODUCTION The purpose ofthis document is to conveyusage information and a broad overview ofthe pest management roles ofpesticides that are beginning to undergo registrationreview. The anticipated audience consists ofthe team ofEPA staffcurrently evaluating the registration status ofCyprodinil (288202), and eventually the general public. This document builds upon the data already provided inthe "Usage and Label Use DataPackages" that are also provided to
1Registration Reviewteams by BEAD. The document is based on information and data available to BEAD as ofSeptember 6, 2011. Cyprodinil inhibits methionine biosynthesis infungi and belongs to fungicide group 9 (FRAC, 2010). Ithas protectant and some curative properties againstplantpathogenic fungi. Itis effective against many phytopathogenic fungi causing plantdiseases onvarious agricultural crops. USE SITES Agricultural Cyprodinil is a fungicide labeled for use onthe following agricultural crops: bushberries, caneberries, grapes, strawberries, citrus, almonds, pistachios, pome fruit, stone fruit, tropical fruit, herbs, cucurbits, tomatoes, tomatillo, leafy vegetables, cole crops, root crops, bulb vegetables, beans andpeas (dried/succulent), lupine (forage/fodder), and ornamentals (field grown/nurseries) Non-Agricultural Cyprodinil is also labeled for use on ornamentals and landscaped areas around institutional, public, commercial and industrial buildings, parks, recreational areas, and athletic fields. COMMON FORMULATIONS AND APPLICATION METHODS Cyprodinil is formulated as water dispersible granules and as an emulsifiable concentrate and applied using the application methods listed in Table 1.
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a e ;ypro tru**~ppllcatIOn** Mthd e o s Crop Application Method Application Equipment Application Timin2 Orchard Broadcast; Aircraft; Ground; Foliar; Pink, Bloom; Late spring; Petal Fall; Crops Chemigation Sprinkler Irrigation Post-bloom, Preharvest Grapes Broadcast Aircraft; Ground AtBudBreak; Foliar; Bloom, Preharvest, Bloomthru Foliar Strawberries Broadcast; Aircraft; Ground; Foliar; Bloom; Prebloom; Pretransplant; Chemigation; Dip Sprinkler Irrigation; Dip Preplant Treatment; Crown & tank Foliar Treatment Other Crops Broadcast; Aircraft; Ground; AtPlanting; Pink; Prebloom; Bloom; Bloom Chemigation; Spray; Sprinkler Irrigation, thru Foliar; Post-Bloom; Foliar; Preharvest; Sprayer



### .. Source: EPA Cyprodmll Label Use InformatIOn System (LUIS)**~eport,** July 2011 USAGE Agricultural Use Trends Cyprodinil use inthe U.S., as reported inprivate market research surveys, increased substantially between 1998 and 2010. Reported use ofcyprodinil averaged approximately 144,000pounds of active ingredient annually and was applied to approximately 500,000 treated acres at an overall applicationrate of0.3 lbs a.i. per acre. The Figure 1below shows usage trends, interms of pounds a.i. applied, for cyprodinil's leading agricultural markets. From 1998-2010, the crops
2with the mostpounds a.i. applied were almonds (40%), wine grapes (22%), table grapes (13%) and strawberries (6%). Cyprodinil use onalmonds, wine and table grapes, and strawberries increased yearly for the mostpart, with marked increases in 2010. These crops ranked similarly withregard to total acres treated. From 2006-2010, cyprodinil use on additional crops, coupled with the increases in use ongrapes and strawberries contributed greatly to the increase in pounds applied and acres treated during thatperiod. As such, the agricultural use summaries below focus on usage for years 2006-2010 to more accurately portray current usage. Figure 1. C rodinil Use Trends, Pounds A.1. A lied, 1998-2010 350,000 "tJ .!!! Q. a. 'it <i. III "tJ C :::s o Q.**~** m 0**~** N m**~ ~** **~ ~** **~** m 0 m moo 0 0 0 0 0 0 0 0**~** m moo 0 0 0 0 0 0 0 0 0**~ ~**  N N N N N N N N N N N Year Source: EPA Proprietary Data, 1998-2010 • Other • Strawberries
• Grapes, Wine
• Grapes, Table

. Almonds

"Other" crops, ranked from highestto lowestpounds a.i. applied, include peaches, plums/prunes, apples, raisin grapes, caneberries, apricots, lettuce, pears, pistachios, cucumbers, onions, watermelons, beans, cherries, pumpkins, cantaloupes, cabbage, squash, asparagus, and garlic. Agricultural Use, 2006-2010 Based onprivate market pesticide usage data from 2006-2010, the annual total agricultural usage averaged approximately 203,000 pounds active ingredient for 677,000 treated acres, for an overall average application rate of0.3 lbs a.i. per acre. From 2006-2010, the crops withthe mostpounds a.i. applied were almonds (36%), wine grapes (20%), table grapes (14%), and strawberries (8%), as shown inFigure 2. The overall average application rate for these crops was 0.3 lbs a.i. per acre. The above crops also ranked similarly with regard to total acres treated (TAT). Figure 2. Cyprodinil: Top Crops for Pounds AI Applied, 2006-2010

Strawberries 8% Source: EPA Proprietary Data, 2006-2010



### '3Onaverage, the states with the most agricultural usage interms ofpounds a.i. applied were California (88%), Washington (2%), Oregon (3%) andNew York (2%), as shown inFigure 3. Figure 3. Cyprodinil: Top States for Pounds AI Applied, 2006-2010

• California
• NewYork • Oregon
• Washington
• Other 

# I**~----~--~--~~~~~~~~~~ ~**  Source: EPA Proprietary Data, 2006-2010 "Other" states include CT, NM, GA, TX, OR, WV, IN, NJ, NC, VA, SC, FL, PA, and MI. Agricultural Use: Nurseries and Floriculture During 2006, 700 pounds ofcyprodinil was reported to be applied innurseries at an average rate ofO.299lbs/acre according to the 2007 USDANASS Agricultural Chemical Usage, Nursery & Floriculture report. In 2009, only 100 pounds ofcyprodinil was reported to be applied in nurseries at an average rate of0.263 lbs/acre according to the 2011 USDANASS Agricultural Chemical Usage, Nursery & Floriculture report. BIOLOGICALASPECTS RELEVANT TO CYPRODINIL Cyprodinil inhibits methionine biosynthesis infungi and belongs to fungicide group 9 (FRAC, 2010). Cyprodinil is a systemic fungicide. After foliar application itis up takeninto plants and transported throughoutthe plant (Tomlin, 1997). Cyprodinil was registered inthe united States in 1998 and since thenresistance inBotrytis causing gray mold disease and Venturia causing apple scab have beenreported (FRAC, 2010). Itis not out ofthe ordinarythat resistance inthese two fungi has been reported because they have highpropensity to develop resistance against fungicides because oftheir genetic makeup. The risk offungi developing resistance against this fungicide is medium and resistance management is recommended (FRAC, 2010). HISTORY OF BEAD ASSESSMENTS FORCYPRODINIL Usage Report in Support ofReregistration for the Fungicides DCNA (031301) & Fenhexamid (090209), Iprodione (109801), Vinclozolin (113201), and Chlorothalonil (081901), Coniothyrium minitans (028836), Captan (081301), Trifloxystrobin (129112), Cyprodinil (288202), Iprodione (109801), Thiophanate-methyl (102001), Kresoxim-methyl (129111). Jenna Carter onApril 10, 2006. 

### Section 18 Emergency Request History:

4Cyprodinil was registeredinthe United States in 1998 for the control offungal diseases on some crops. During 1999- 2008, many States (such as Oregon, Washington, Georgia and Indiana) requested its emergency on strawberry, caneberries, leafy vegetables, cucurbits and watermelons (please see references) to control fungal diseases. Since then cyprodinil has beenregistered for use onthese crops (CDMS, 2011). Presently, there is no emergency exemptionrequest for this fungicide on any crop. DATA NEEDS RELEVANT TO BEAD'S FUTURE WORK ON CYPRODINIL Nonagricultural use data would be most helpful for future work oncyprodinil. REFERENCES Carter, J. 2006. Usage Report in Support ofReregistration for the Fungicides DCNA (031301) & Fenhexamid (090209), Iprodione (109801), Vinclozolin (113201), and Chlorothalonil (081901), Coniothyrium minitans (028836), Captan (081301), Trifloxystrobin (129112), Cyprodinil (288202), Iprodione (109801), Thiophanate-methyl (102001), Kresoxim-methyl (129111). Jenna Carter. AprillO, 2006. Chand-Goyal, T. and A. Lee. 2008. Review ofa Section 18 Request for the Emergency Use of Tank Mixed Cyprodinil(08-GA-02, DP

### # 351243) and Difenoconazole (08-GA-Ol, DP 

### # 351235) on Cucurbits inGeorgiato Control Gummy Stem Blight Disease Causedby 

### Didymella bryonia. May 2, 2008. Chand-Goyal, T. and A. Lee. 2008. Review ofa Section 18 Request for the Emergency Use of Tank Mixed Cyprodinil(08-1N-02, DP 

### # 353505) and Difenoconazole (08-IN-Ol, DP # 353500) onWatermelons inIndianato Control Gummy Stem Blight Disease Caused by

### Didymella bryonia. August 19,2008. Chand-Goyal, T. and F. Hernandez. 1998. Review ofFloridaEmergency Exemption Request for the Use ofCyclohexanecarboxamide (99-FL-Ol, D250835 and D250834), Cyprodinil (99- FL-02, D250843 and D250841) and Fludioxinil (99-FL-03, D250855 and D250854) to Control Gray Mold Disease (causedby

### Botrytis cinerea) on Strawberry Plants. December 1, 1998. Chand-Goyal, T. and F. Hernandez. 1999. Review ofaRegion Specific Emergency Exemption Request Submittedby Oregon for the Use ofElevate (fenhexamid) and Switch (cyprodinil and fludioxonil) in Oregon and Washington on StrawberryPlants to Control Gray MoldDisease Causedby Botrytis cinerea (99-0R-28, D254531 and D254533). April 13, 1999. CDMS. 2011. http://premier.cdms.netlwebapls/FormsLogin.asp?/webapls/ Donaldson, D. and R. Michell. 2000. Washington and Oregon Emergency Exemption Requests to Use Switch (Fludioxonil plus Cyprodinil) and Elevate (Fenhexamid) for Control ofBotrytis onCaneberries (00-WA-20; 00-OR-18)(D263951 andD263952). April 25, 2000. EPA Cyprodinil Label Use Information System Report (LUIS), July 2011

5EPA Proprietary Data (1998-2010) FRAC. 2010. Fungicide Resistance Action Committee Code List. Assessed 08.24.2011 http://www.frac.info/frac/publicationlanhang/FRAC Code List 201O.pdf Hernandez, F. and R. Michell. 1999. Washington and Oregon Requests for Emergency ExemptionUse ofSwitch (Fludioxonil plus Cyprodinil) and/or Elevate (Fenhexamid) to Control Botrytis on Caneberries (99-WA-31; 99-0R-37). June 16, 1999. Second Reduced Risk Determination for Cyprodinil (CGA 219417). Nov. 6, 1996

-- Hard copy only. Tomlin, CDS. 1997. The Pesticide Manual. Published bythe British Crop Protection CouncilFarnham, Surrey GU9 7PH, UK. 1606pp. USDANASS (2007,2011), Agricultural Chemical Usage, Nursery & Floriculture Report. Yourman, L. and I. Yusuf. 2003. Request for Emergency Exemption Use ofaFungicide Mix of Fludioxonil (03TX09) and Cyprodinil (03TX12) to Manage Powdery Mildew on Leafy Vegetables inTexas [DP Barcodes D289210, D289213; Case # 295959,295962]. May 28, 2003.



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