This Warrant and the securities underlying
this Warrant have not been registered under the Securities Act of 1933, as amended (the “Securities Act”) and may not
be offered, sold or otherwise transferred, assigned, pledged or hypothecated in the absence of such registration or an exemption
therefrom under such Securities Act, any applicable state securities laws and the rules and regulations thereunder.


 


PROTEA BIOSCIENCES GROUP, INC.


 


WARRANT


 


TO PURCHASE COMMON STOCK OF THE COMPANY


 


	Warrant No. 407	Issue Date:  April 18, 2012


 


FOR VALUE RECEIVED,
PROTEA BIOSCIENCES GROUP, INC., a Delaware corporation (the “Company”), grants the following rights to West Virginia
Jobs Investment Trust Board, its successors, permitted assigns, heirs, executors and administrators (individually and collectively,
the “Holder”), as of the 18th day of April, 2012 (“Issue Date”). This warrant (the “Warrant”)
has been issued by the Company in connection with the issuance by the Company of its Convertible Debenture to West Virginia Jobs
Investment Trust Board and of even date herewith (the “Convertible Debenture”), which by its terms is accompanied by
the delivery to the Holder of one Warrant to purchase the Company’s Common Stock on the terms and conditions set forth herein.


 


Section 1.Grant.


 


The Holder is hereby
granted the right (collectively, the “Purchase Rights”), in accordance with the terms and conditions of this Warrant,
from the date hereof until the expiration of the “Exercise Period” (as defined below), to purchase from the Company
that number of fully paid and non-assessable shares of Common Stock of the Company, par value $0.0001 per share, set forth in Section
2 hereof, at the “Exercise Price” (as defined below), upon delivery of this Warrant to the Company with the Notice
of Exercise form attached as Exhibit 1 hereto, duly executed, and upon tender of the Exercise Price for the shares of Common
Stock to be purchased.


 


Section 2.Number of Shares
of Common Stock Purchasable.


 


2.1Subject to the other provisions
of this Section 2, this Warrant entitles the Holder to purchase from time to time up to 88,889 shares of the Company’s Common
Stock (the “Warrant Shares”).


 


2.2In case prior to the expiration
of these Purchase Rights by exercise or by the terms of this Warrant the Company shall undertake any reclassification, stock split,
reverse stock split, stock dividend or any similar proportionately-applied change (collectively, a “Reclassification”)
of outstanding shares of Common Stock (other than a change in, of, or from par value), the Holder shall thereafter be entitled,
upon exercise of this Warrant, to purchase the kind and amount of shares of stock and other securities and property receivable
upon such Reclassification by a holder of the number of shares of Common Stock which this Warrant entitles the Holder hereof to
purchase immediately prior to such Reclassification. Notice of any such Reclassification shall be given to the Holder pursuant
to Section 11 hereof.


 






    	 



    	 	



    
 


2.3In case prior to the expiration
of these Purchase Rights by exercise or by the terms of this Warrant the Company shall determine to consolidate or merge with,
or convey all, or substantially all, of its property or assets to, any other corporation or corporations, or dissolve, liquidate
or wind up, then, as a condition precedent to such consolidation, merger, conveyance, dissolution, liquidation or winding up, notice
shall be given to the Holder pursuant to Section 11 hereof and lawful and adequate provision shall be made whereby the Holder shall
thereafter have the right to receive from the Company or the successor corporation, as the case may be, upon the basis and upon
the terms and conditions specified in this Warrant, in lieu of the shares of Common Stock of the Company theretofore purchasable
upon the exercise of the Purchase Rights, such shares of stock, securities, or assets as may be issued or payable with respect
to, or in exchange for, the number of shares of Common Stock of the Company theretofore purchasable upon the exercise of the Purchase
Rights had such consolidation, merger, conveyance, dissolution, liquidation or winding up, not taken place; and in any such event
the rights of the Holder to an adjustment of the number of shares of Common Stock purchasable upon the exercise of the Purchase
Rights as herein provided, shall continue and be preserved in respect of any stock or securities which the Holder becomes entitled
to purchase.


 


Section 3.Exercise Period;
Registration Statement Notice.


 


3.1The Purchase Rights represented
hereby shall be exercisable in whole or in part from time to time after the date of issuance of this Warrant until the earlier
of (i) a Qualified Public Offering, or (ii) 5:00 p.m. Eastern time on the fifth anniversary of the Issue Date hereof (the “Exercise
Period”). For purposes of this Warrant, the term “Qualified Public Offering” shall mean the closing of a firm
commitment underwritten offering pursuant to an effective registration statement under the Securities Act covering the offer and
sale of Common Stock for the account of the Company in which the net cash proceeds to the Company (after deduction of underwriting
discounts, commissions and fees) are at least $15,000,000.


 


3.2The Company shall give the Holder
written notice, at the address of the Holder set forth on the Company’s books, not less than ten days prior to the filing
of any registration statement with respect to a Qualified Public Offering.


 


Section 4.Exercise.


 


4.1The Purchase Rights represented
by this Warrant are exercisable upon the terms and conditions set forth herein at the option of the Holder in whole at any time
and in part, but not for less than 15,000 shares at a time, at any time and from time to time during the Exercise Period, upon
the delivery of the Notice of Exercise form attached hereto as Exhibit 1, to the Company with such notice duly executed
and upon payment in cash, wire transfer or bank cashier’s or certified check of the Exercise Price. The Purchase Rights shall
be deemed to have been exercised, and the Holder shall be deemed to have become a stockholder of record of the Company for the
purposes of receiving dividends and for all other purposes whatsoever with respect to the shares of Common Stock so purchased,
as of the date of delivery of such properly executed notice accompanied by tender of the Exercise Price at the office of the Company.
As promptly as practicable on or after such date, and in any event within 20 business days thereafter, the Company at its expense
shall issue and deliver, or cause to be issued and delivered, to the person or persons entitled to receive the same, a certificate
or certificates for the number of shares issuable upon such exercise. In the event that this Warrant is exercised in part, the
Company at its expense will execute and deliver a new Warrant of like tenor exercisable for the number of shares for which this
Warrant may then be exercised.


 






    	 



    	 	



    
 


Section 5.Exercise Price.The
Exercise Price for each share of Common Stock issuable to the Holder hereunder shall be $2.25 per share.


 


Section 6.Company’s
Warranties and Covenants as to Capital Stock. The Company has taken all action necessary and appropriate to properly
authorize, reserve and issue those shares of Common Stock issuable to the Holder pursuant to this Warrant including an authorization
of issuance and setting of the Exercise Price. The Common Stock deliverable on the exercise of the Purchase Rights represented
hereby shall, when issued, be duly and validly issued, fully paid and nonassessable. The Company shall at all times reserve and
hold available sufficient shares of Common Stock to satisfy all conversion and purchase rights of all outstanding convertible securities
and warrants.


 


Section 7.Transfer.The
Purchase Rights shall be registered on the books of the Company, which shall be kept by it at its principal office for that purpose.
This Warrant and the Common Stock issuable upon exercise of the Purchase Rights, may not be transferred or assigned in whole or
in part without compliance with all applicable federal and state securities laws by the transferor and the transferee, including,
if requested by the Company, an opinion of counsel satisfactory to the Company to the effect that the transfer or assignment is
in compliance with applicable securities laws. Subject to such compliance, the Purchase Rights shall be transferable on said books,
in whole or in part, by the Holder in person or by duly authorized attorney upon surrender of this Warranty properly endorsed by
the Holder executing the Assignment Form attached hereto and made a part hereof as Exhibit 2. All costs associated with
any transfer or assignment, including, without limitation, the reasonable fees of counsel to the Company shall be borne by the
transferor or assignor. The Company agrees that, while the Purchase Rights remain valid and outstanding, its stock transfer books
shall not be closed for any purpose whatsoever except under arrangements which shall insure to personal exercising warrants or
applying for transfer of stock all rights and privileges which they might have had or received if the stock transfer books had
not been closed and they had exercised their Purchase Rights at any time during which such transfer book shall have been closed.


 


Section 8.Charges, Taxes
and Expenses.Issuance of certificates for shares of Common Stock issuable upon the exercise of this Warrant or
any portion thereof (and issuance of a replacement Warrant certificate in the event of partial exercise) shall be made without
charge to the Holder hereof for any issue taxes or any other incidental expenses in respect of the issuance of such certificates
to and in the name of the registered Holder of this Warrant, all of which taxes and expenses shall be paid by the Company, and
such certificates shall be issued in the name of the Holder of this Warrant. Certificates will be issued in a name other than that
of the Holder upon the request of a Holder and payment by the Holder of any applicable transfer taxes and compliance with all applicable
securities laws.


 






    	 



    	 	



    
 


Section 9.Exchange for
Other Denominations.This Warrant is exchangeable for new certificates of like tenor and date representing
in the aggregate the right to purchase the number of shares purchasable hereunder in denominations designated by the Holder at
the time of surrender. In the event of the purchase, at any time prior to the expiration of the Exercise Period, of less than all
of the shares of Common Stock purchasable hereunder, the Company will cancel this Warrant upon surrender thereof, and will forthwith
execute and deliver to the Holder hereof a new warrant of like tenor and date for the balance of the shares purchasable hereunder.


 


Section 10.Loss, Theft,
Destruction or Mutilation of Warrant.Upon receipt by the Company of evidence reasonably satisfactory to it of the
loss, theft, destruction or mutilation of this Warrant, and, in case of loss, theft or destruction, of indemnity or security reasonably
satisfactory to it, and upon reimbursement to the Company of all reasonable expenses incidental thereto, and upon surrender and
cancellation of this Warrant, if mutilated, the Company will make and deliver a new warrant of like tenor and date, in lieu of
this Warrant.


 


Section 11.Notices.


 


(a)Whenever the number of shares purchasable
hereunder shall be adjusted pursuant to Section 2 hereof, the Company shall issue a certificate signed by its Chief Financial
Officer or such other appropriate officer, setting forth, in reasonable detail, the event requiring the adjustment, the amount
of the adjustment, the method by which such adjustment was calculated, and the number of shares purchasable hereunder after giving
effect to such adjustment, and shall cause a copy of such certificate to be mailed (by first-class mail, postage prepaid) to the
Holder of this Warrant.


 


(b)In case:


 


(i)the Company shall take a record
of the holders of its Common Stock for the purpose of entitling them to receive any dividend or other distribution, or any right
to subscribe for or purchase any shares of stock of any class or any other securities, or to receive any other right, or


 


(ii)of any capital reorganization
of the Company, any reclassification of the capital stock of the Company, any consolidation or merger of the Company with or into
another corporation, or any conveyance of all or substantially all of the assets of the Company to another corporation, or


 


(iii)of any voluntary dissolution,
liquidation or winding-up of the Company,


 






    	 



    	 	



    
 


then, and in each such case, the Company
will mail or deliver or cause to be mailed or delivered to the Holder or Holders a notice specifying, as the case may be, (A) the
date on which a record is to be taken for the purpose of such dividend, distribution or right, and stating the amount and character
of such dividend, distribution or right, or (B) the date on which such reorganization, reclassification, consolidation, merger,
conveyance, dissolution, liquidation or winding-up is to take place, and the time, if any is to be fixed, as of which the holders
of record of Common Stock shall be entitled to exchange their shares of Common Stock for securities or other property deliverable
upon such reorganization, reclassification, consolidation, merger, conveyance, dissolution, liquidation or winding-up. Such notice
shall be mailed or delivered at least 15 business days prior to the date therein specified.


 


(c)All notices, requests, consents
and demands required by this Warrant shall be in writing and shall be personally delivered or mailed, postage prepaid, in the following
manner:


 


If to the Holder:


 


West Virginia Jobs
Investment Trust Board


Fifth Floor, 1012 Kanawha
Boulevard, East


Charleston, WV 25301


Attention: Executive
Director


Telephone No. 304-345-6200


Fax: 304-345-6262


 


If to the Company:


 


PROTEA BIOSCIENCES
GROUP, INC.


955 Hartman Run Road


Morgantown, WV 26507


Attention: Stephen
Turner


Telephone: 304-292-2226


Fax: 304-292-7101


 


or to such address or addresses as provided
by Company or by Holder by such a notice. All notices required or permitted hereunder shall be in writing and shall be deemed effectively
given: (i) upon personal delivery to the party to be notified, (ii) when sent by confirmed facsimile if went during normal business
hours of the recipient, if not, then on the next business day, (iii) five (5) days after having been sent by registered or certified
mail, return receipt requested, postage prepaid, or (iv) one (1) day after deposit with a nationally recognized overnight courier,
specifying next day delivery with written verification of receipt.


 


Section 12.Miscellaneous.This
Warrant shall not entitle the Holder to any of the rights of a stockholder of the Company. This Warrant shall be binding upon the
Company’s successors. This Warrant shall be governed, construed and enforced in accordance with the laws of the State of
Delaware. In case any provision of this Warrant shall be invalid, illegal or unenforceable, or partially invalid, illegal or unenforceable,
the provision shall be enforced to the extent, if any, that it may legally be enforced and the validity, legality and enforceability
of the remaining provisions shall not in any way be affected or impaired thereby. This Warrant shall any term hereof may be changed,
waived, discharged or terminated only by a statement in writing signed by the party against which enforcement of such change, waiver,
discharge or termination is sought. The headings in this Warrant are for purposes of reference only, and shall not limit or otherwise
affect any of the terms hereof.


 






    	 



    	 	



    
 


 


IN WITNESS WHEREOF,
the parties have caused this Warrant to be duly executed, under seal and delivered on its behalf as of the 18th day
of April, 2012.


 


 



 


	 	PROTEA BIOSCIENCES
GROUP, INC. (SEAL)
	 	 
	 	By: 	/s/ Stephen Turner
	 	 	Stephen Turner
President



 



 


	 	WEST VIRGINIA JOBS
INVESTMENT TRUST BOARD
	 	 
	 	By: 	/s/ C. Andrew Zulauf
	 	 	C. Andrew Zulauf, Executive
Director



 









    	 



    	 	



    
 





EXHIBIT 1


 


NOTICE OF EXERCISE PURSUANT TO


ATTACHED WARRANT


 


_________, 20___


 


 


To: PROTEA BIOSCIENCES GROUP, INC.


 


(1)The undersigned, the Holder
of record of the attached Warrant of PROTEA BIOSCIENCES GROUP, INC., hereby exercises the option granted by the Purchase Rights
evidenced by the attached Warrant to purchase upon the terms set forth in such Warrant [________] shares of Common Stock, which
constitutes all [or a portion] of the shares of Common Stock issued pursuant to the Purchase Rights represented by this Warrant,
of PROTEA BIOSCIENCES GROUP, INC., and hereby tenders payment of the Exercise Price as determined by the Warrant.


 


(2)In exercising this Warrant,
the undersigned hereby confirms and acknowledges that (a) the shares of the Common Stock to be issued are being acquired solely
for investment and solely for the account of the undersigned and (b) the undersigned will not offer, sell or otherwise dispose
of any such shares of Common Stock except under circumstances that will not result in a violation of the Securities Act of 1933,
as amended, or any applicable state securities laws. The undersigned further acknowledges that the certificate[s] evidencing the
shares of Common Stock shall bear a legend to the effect of clause (b) above.


 


(3)Please issue a certificate or
certificates representing said shares of Common Stock in the name of the undersigned or in such other name as is specified below:


 


(4)Please issue a new Warrant for
the unexercised portion of the attached Warrant in the name of the undersigned or in such other name as is specified below:


 





	ATTEST:	 	HOLDER:	
	 	 	 	 
	 	 	 	 
	 	 	By:	 
	 	 	 	 
	 	 	Name:	 
	 	 	 	 
	 	 	Title:	 







 


(If certificates for Common Stock or new
Warrants are requested in a name other than the undersigned, be advised that the delivery of the certificates and/or new Warrants
will be delayed until the Company assures itself that such change is permitted under Section 7 of the Warrant that such change
does not violate applicable federal and state securities laws.)


 






    	 



    	 	



    
 


EXHIBIT 2


 


TRANSFER OR ASSIGNMENT FORM


 


FOR VALUE RECEIVED,
the undersigned Holder of record of this Warrant of PROTEA BIOSCIENCES GROUP, INC., hereby sells, assigns and transfers unto the
Assignee named below all of the rights of the undersigned under the within Warrant, with respect to the number of shares of Common
Stock set forth below:


 





	Name of Transferee/Assignee	Address	No. of Shares







 


 


and does hereby irrevocably constitute
and appoint the Secretary of PROTEA BIOSCIENCES GROUP, INC. to make such transfer on the books of PROTEA BIOSCIENCES GROUP, INC.,
maintained for the purpose, with full power of substitution in the premises.


 


Attached hereto is
an opinion of counsel that the assignment does not violate or is exempt from, any federal and state securities laws. The Company
may, in its sole discretion, decide whether such opinion is satisfactory, and Assignee and Holder agree to any reasonable delay
in transfer caused by such evaluation.


 


The undersigned also
represents that, by assignment hereof, the Assignee acknowledges that this Warrant and the shares of Common Stock to be issued
upon exercise hereof or conversion thereof are being acquired for investment and that the Assignee will not offer, sell or otherwise
dispose of this Warrant or any shares of stock to be issued upon exercise hereof or conversion thereof except under circumstances
which will not result in a violation of the Securities Act of 1933, as amended, or any state securities laws. Further, the Assignee
has acknowledged that upon exercise of this Warrant, the Assignee shall, if requested by the Company, confirm in writing, in a
form satisfactory to the Company, that the shares of stock so purchased are being acquired for investment and not with a view toward
distribution or resale in violation of applicable securities laws.


 





	Dated: 	 	 	HOLDER:	 
	 	 	 	 	 
	 	 	 	By:	 
	 	 	 	Name:	 
	 	 	 	Title:	 
	 	 	 	 	 
	Dated:	 	 	ASSIGNEE: 	 
	 	 	 	 	 
	 	 	 	By:	 
	 	 	 	Name:	 
	 	 	 	Title: