Exhibit 10.22

FIRST AMENDMENT TO MASTER REPURCHASE AGREEMENT

FIRST AMENDMENT TO MASTER REPURCHASE AGREEMENT dated as of June 30, 2014 (this Amendment), by and among
CB LOAN NT-II, LLC, a Delaware limited liability company (Seller), and CITIBANK, N.A., a national banking association (Buyer), and acknowledged and agreed to
by NORTHSTAR REAL ESTATE INCOME II, INC., a Maryland corporation (Guarantor). Capitalized terms used but not otherwise defined herein shall have the meanings given to them in the MRA (defined below).

RECITALS

WHEREAS,
Seller and Buyer are parties to that certain Master Repurchase Agreement, dated as of October 15, 2013 (as the same may be further amended, supplemented or otherwise modified from time to time, the MRA);

WHEREAS, in connection with the MRA, Guarantor entered into that certain Limited Guaranty dated as of October 15, 2013 (as the
same may be amended, supplemented or otherwise modified from time to time, the Guaranty), in favor of Buyer, guaranteeing certain obligations of Seller;

WHEREAS, Seller and Buyer wish to amend the MRA as more particularly set forth herein, and Guarantor wishes to reaffirm the covenants
made in the Guaranty.

NOW THEREFORE, in consideration of the premises and for other good and valuable consideration, the receipt
and sufficiency of which are hereby acknowledged, Seller and Buyer and Guarantor hereby agree as follows:

SECTION 1.
Amendment to Master Repurchase Agreement.

(a) The following definition in Section 2 of the MRA is hereby
deleted in their entirety and the following corresponding definition is substituted therefor:

Manager
shall mean NorthStar Asset Management Group Inc., a Delaware corporation, or a subsidiary thereof.

(b) The following is
hereby added after the last sentence of Section 5(b) of the MRA:

Notwithstanding anything contained in
this Section 5(b), Seller shall only be obligated to deliver or cause to be delivered an Irrevocable Direction Letter to each Mortgagor or issuer of a participation under a Purchased Loan if (x) an Event of Default has occurred and is
continuing under this Agreement or (y) Buyer delivers to Seller a written notice requiring Seller to send Irrevocable Direction Letters to each Mortgagor or issuer of a participation under a Purchased Loan.

SECTION2. Omnibus Amendment to Transaction Documents. Any references to the MRA in the Transaction Documents
shall hereinafter refer to the MRA as modified by this Amendment.





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SECTION3. Reaffirmation of Guaranty. Guarantor acknowledges the
amendments and modifications of the MRA pursuant to this Amendment and hereby ratifies and reaffirms all of the terms, covenants and conditions of the Guaranty and agrees that the Guaranty remains unmodified by this Amendment and in full force and
effect and enforceable in accordance with its terms.

SECTION4. Due Authority. Each of Seller and
Guarantor hereby represents and warrants to Buyer that, as of the date hereof, (i) it has the power to execute, deliver and perform its respective obligations under this Amendment, (ii) this Amendment has been duly executed and
delivered by it for good and valuable consideration, and constitutes its legal, valid and binding obligation enforceable against it in accordance with its terms subject to bankruptcy, insolvency, and other limitations on creditors rights
generally and to equitable principles, and (iii) neither the execution and delivery of this Amendment, nor the consummation by it of the transactions contemplated by this Amendment, nor compliance by it with the terms, conditions and
provisions of this Amendment will conflict with or result in a breach of any of the terms, conditions or provisions of (A) its organizational documents, (B) any contractual obligation to which it is now a party or the rights
under which have been assigned to it or the obligations under which have been assumed by it or to which its assets are subject or constitute a default thereunder, or result thereunder in the creation or imposition of any lien upon any of its assets,
other than pursuant to this Amendment, (C) any judgment or order, writ, injunction, decree or demand of any court applicable to it, or (D) any applicable Requirement of Law, in the case of clauses (A)-(C) above, to the extent
that such conflict or breach is reasonably likely to result in a Material Adverse Effect.

SECTION5.
Counterparts. This Amendment may be executed by each of the parties hereto on any number of separate counterparts, each of which shall be an original and all of which taken together shall constitute one and the same instrument. Delivery of an
executed counterpart of a signature page to this Amendment in Portable Document Format (PDF) or by facsimile transmission shall be effective as delivery of a manually executed original counterpart thereof.

SECTION6. GOVERNING LAW. THIS AMENDMENT SHALL BE GOVERNED BY, AND CONSTRUED AND INTERPRETED IN ACCORDANCE
WITH, THE LAWS OF THE STATE OF NEW YORK, WITHOUT REFERENCE TO ITS CONFLICT OF LAWS PRINCIPALS.

SECTION7.
MRA and Transaction Documents in Full Force and Effect. Except as expressly amended hereby, Seller and Guarantor acknowledge and agree that all of the terms, covenants and conditions of the MRA and the other Transaction Documents remain
unmodified and in full force and effect and are hereby ratified and confirmed in all respects.

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IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed and
delivered as of the day and year first above written.



BUYER:CITIBANK, N.A.By:

/s/ Richard B. SchlengerName: Richard B. SchlengerTitle: Authorized Signatory


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SELLER:



|                                                         |  |                                                                                                                   |  |                                                                                    |  |                                                          |  |                
|-------------------------------------------------------- |  | ----------------------------------------------------------------------------------------------------------------- |  | ---------------------------------------------------------------------------------- |  | -------------------------------------------------------- |  | ---------------
|CB LOAN NT-II, LLC,
a Delaware limited liability company
|                                                         | 
|By:                                                      |  | NorthStar Real Estate Income Operating Partnership II, LP, a Delaware limited partnership, its sole equity member
|                                                         |  |                                                                                                                  
|                                                         |  | By:                                                                                                               |  | NorthStar Real Estate Income II, Inc., a Maryland corporation, its general partner
|                                                         |  |                                                                                                                   | 
|                                                         |  |                                                                                                                   |  | By:                                                                                |  | /s/ Jenny B. Neslin                                     
|                                                         |  |                                                                                                                   |  |                                                                                    |  | Name:                                                    |  | Jenny B. Neslin
|                                                         |  |                                                                                                                   |  |                                                                                    |  | Title: Associate General Counsel and Assistant Secretary

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ACKNOWLEDGED AND AGREED TO AS OF
, 2014:GUARANTOR:NORTHSTAR REAL ESTATE INCOME II, INC.,
a Maryland corporationBy:

/s/ Jenny B. NeslinName: Jenny B. NeslinTitle: Associate General Counsel and
Assistant Secretary