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Lujo Hemorrhagic Fever (LUHF)


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Signs and Symptoms								Related Pages
										The symptoms of Lujo hemorrhagic fever, as described in the five patients in the original cluster outbreak, resemble those of severe Lassa Fever. After an incubation period of 7 to 13 days, the clinical course started by a non-specific febrile illness accompanied by headache and muscle pain.
The disease increases in severity, with:
a morbilliform rash of the face and trunk
face and neck swelling
pharyngitis (sore throat)
diarrheaBleeding was not a prominent feature during the illness.
In the fatal cases (4/5 patients), a transient improvement was followed by:
rapid deterioration with respiratory distress
neurological signs and circulatory collapseDeath occurred 10 to 13 days after onset.
Low blood platelets, low white blood cell count (at the onset, rising later on) and elevated liver function values were present in all patients.
Since Arenaviruses may enter the fetus through infection of the mother, and anecdotal evidence suggests that infected pregnant women may suffer miscarriages, it is reasonable to assume that both infection of the fetus and miscarriage may be associated with Lujo infection in the mother.
										
							
								Page last reviewed:  June 18, 2013						Content source:  	Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Division of High-Consequence Pathogens and Pathology (DHCPP), Viral Special Pathogens Branch (VSPB) Lujo Hemorrhagic Fever (LUHF)
Transmission
Signs & Symptoms
Risk of Exposure
Diagnosis
Treatment
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Resources About VSPB (Viral Special Pathogens Branch)


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