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Lujo Hemorrhagic Fever (LUHF)


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Lujo Hemorrhagic Fever (LUHF)																									Related Pages
												Lujo hemorrhagic fever (LUHF) is caused by Lujo virus, a single-stranded virus of the Arenaviridae family. The limited clinical information about LUHF comes from a small, nosocomial cluster of hemorrhagic disease in September-October 2008 involving 5 patients in South Africa. The case fatality rate was 80% (4/5 cases).
The first patient, whose source of infection was unknown, was the source of infection of 3 health care workers. A tertiary infection occurred in a fourth healthcare worker who received ribavirin treatment and was the only survivor. Lujo virus is the second African hemorrhagic fever virus described. (Lassa virus was identified in 1969.)TransmissionHumans can contract LUHF through contact with an infected rodent...Signs and SymptomsIn documented cases, clinical course started by a non-specific febrile illness...Risk of ExposureLUHF occurs in southern Africa. Field workers are at greatest risk...DiagnosisLujo virus can be isolated from blood from 2-13 days after onset...TreatmentSupportive therapy is important in Lujo hemorrhagic fever...PreventionRodent control will not be a successful strategy for preventing Lujo...ResourcesViral Hemorrhagic Fever (VHF) Information for Specific Groups
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								Page last reviewed:  June 18, 2013						Content source:  	Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Division of High-Consequence Pathogens and Pathology (DHCPP), Viral Special Pathogens Branch (VSPB) Lujo Hemorrhagic Fever (LUHF)
Transmission
Signs & Symptoms
Risk of Exposure
Diagnosis
Treatment
Prevention
Resources


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