## Support Documents for Significant New Use Rule (SNUR) on Premanufacture Notice (PMN)
P-12-260

EPA Docket EPA-HQ-OPPT-2012-0450

## Index A-001 Structure Activity Team (SAT) Report for PMN P-12-260 A-002 Initial Review Engineering Report for PMN P-12-260 A-003 Initial Review Exposure Report for PMN P-12-260

## A-001 Structure Activity Team (SAT) Report
for PMN P-12-260

### SAT Report PMN Number: P-12-0260 SAT Date: 4/17/2012 Print Date: 5/2/2012

Related cases : Health related cases: Ecotox related cases :

Concern levels : Type of Concern: Health Eco Comments Level of Concern: 1-2 3

Persistence Bioaccum Toxicity Comments 1 11

Exposure Based Review : Health: N o Ecotox: N o
Routes of exposure : Health: Dermal Inhalation Ecotox: All releases to water Fate: ; Keywords : Keywords: LIVER, AQUATOX-A,C
Summary of Assessment :
Fate : Fate Summary: P-12-0260 FATE: Estimations for typical Liquid with MP < 25 C (E) log Kow = 5.04 (E) S = 7.41 mg/L at 25 C (E) VP = 5.9E-5 torr at 25 C (E) BP = 313 C (E) H = 2.87E-6 (E) log Koc = 2.83 (E) log Fish BCF = 1.62 (E) log Fish BAF = 2.48 (E)POTW removal (%) = 90 via sorption and biodeg Time for complete ultimate aerobic biodeg = wk Sorption to soils/sediments = moderate Volatilization half-life from a standard river = 500 hrs Volatilization half-life from a standard lake = 160 da Atmospheric Oxidation Half-life = 9.0 hr via OH radical PBT Potential: P1B1 *CEB FATE: Migration to ground water = slow

Health : Health Summary: Absorption is poor all routes based on analogs. There is concern for liver effects based on the bromo substituent. Low moderate concern

Ecotox :
Test Organism Test Type Test End Point Predicted Measured Comments

fish 96-h LC50 1.4 daphnid 48-h LC50 0.36 green algal 96-h EC50 0.36 fish

_ chronic value 0.026 daphnid

_ chronic value 0.047
algal

_ chronic value 0.36
Sewage Sludge 3-h EC50

_ Sewage Sludge

_ Chronic Value _

Ecotox Values Comments: Predictions are based on SARs for halo-alcohols; SAR chemical class = halo-alcohol; MW 307; log Kow 3.33 (EPI); mp = 203 C (M); S = 0.57 g/L (P); effective concentrations based on 100% active ingredients and mean measured concentrations; hardness <150.0 mg/L as CaCO3; and TOC <2.0 mg/L;

Factors Values Comments Assessment Factor 10 Concentration of Concern ( p pb) 3

SARs halo-alcohols SAR Class halo-alcohol Ecotox Category N one
Ecotox Factors Comments:

SAT Chair: Becky Jones

## A-002 Initial Review Engineering Report
for PMN P-12-260INITIAL REVIEW ENGINEERING REPORT PMN: 12-0260 Focus Ready Draft 4/23/2012
ENGINEER: Austin \ DDH PV (kg/yr):

SUBMITTER:

USE:

OTHER USES:

MSDS: No Label: No

TLV/PEL: MSDS not provided

CRSS (04/16/2012):

Consumer Use:
SAT (concerns) (04/17/2012): Migration to groundwater: Slow PBT rating: P1B1T1Health: 1-2 Dermal, Inhalation Eco: 3 Water (All releases to water with a CC = 3 ppb)

OCCUPATIONAL EXPOSURE RATING: 1A

NOTES & KEY ASSUMPTIONS: Generated by the 06/07/2005 version of ChemSTEER.

POLLUTION PREVENTION CONSIDERATIONS:

EXPOSURE-BASED REVIEW:INITIAL REVIEW ENGINEERING REPORT PMN: 12-0260

ENVIRONMENTAL RELEASES ESTIMATE SUMMARY IRER Note: The daily releases listed for any source below may coincide with daily releases from the other sources to the same medium.

OCCUPATIONAL EXPOSURES ESTIMATE SUMMARYINITIAL REVIEW ENGINEERING REPORT PMN: 12-0260

ENVIRONMENTAL RELEASES ESTIMATE SUMMARY IRER Note: The daily releases listed for any source below may coincide with daily releases from the other sources to the same medium.OCCUPATIONAL EXPOSURES ESTIMATE SUMMARY

MEMORANDUM of CBI TELEPHONE CONVERSATION
CALL BY: Daryl Hudson Organization: ERG for CEB/OPPT

CALL TO:
Organization:

Date: 04/18/2012

Time: 10:30 AM

Phone:

PMN: 12-0260

## A-003 Initial Review Exposure Report
for PMN P-12-260Page 1 of 1

POST FOCUS EXPOSURE REPORT Release information for this compound does not meet criteria for preparation of an exposure assessment; were eliminated and the were be low the threshold for exposure assessment

Assessor:

ENVIRONMENTAL RELEASES

Scenario#: Number of Release Sites: Release Activity:
Release Description: WATER LANDFILL INCINER LAND/INCIN FUGITIVE

Total Releases: (kg/yr) (kg/yr) (kg/yr) (kg/yr) (kg/yr) Release Days/yr:

Per Site Release: (kg/day) (kg/yr) (kg/yr) (kg/yr) (kg/day)

Remarks: EAB DROP: Release information for this compound does not meet criteria for preparation of an exposure assessment in the Exposure Assessment Branch = s (EAB) Initial Review Exposure Report (this report).