Infant Environmental

Exposure to Thimerosal

and Neuropsychological

Outcomes at Ages 7 to

10 Years

Technical Report

Volume II

Date 9-6-07

Prepared for

Immunization Safety Office

Centers for Disease Control and

Prevention

1600 Clifton Rd, N.E.,

Atlanta, GA 30333

Prepared by

Cristofer Price

Barbara Goodson

Gerrie Stewart

Cambridge, MA

Lexington, MA

Hadley, MA

Bethesda, MD

Chicago, IL

Abt Associates Inc.

Suite 800 North

4550 Montgomery Avenue

Bethesda, MD 20814-3343
Abt Associates, Inc. Technical Report: Volume II i

The interpretations of results presented in this report represent the

views of the authors and do not necessarily represent the views of

the Centers for Disease Control and Prevention (CDC).
Abt Associates, Inc. Technical Report: Volume II ii

Table of Contents – Volume II

1. Appendix A. Note Concerning Results from Preliminary Analyses........................ 1

2. Appendix B: Full Detail of Results from Model 1.................................................... 2

3. Appendix C. Model Checking with Partial-Partial Residual Plots........................ 46

3.1. Partial-partial Plots for HepB Effects...................................................................... 47

3.2. Partial-partial plots for PreNatThimer Effects....................................................... 49

3.3. Partial-partial plots for Exp17mos Effects.............................................................. 49

3.4. Sensitivity Testing ...................................................................................................... 49

3.4.1. Results .................................................................................................................................. 50

4. Appendix D. Change in Estimate and Precision as Covariates Are Dropped ....... 96

4.1. PreNatThimer............................................................................................................. 98

4.2. Exp07mos.................................................................................................................. 120

4.3. HepB.......................................................................................................................... 142

5. Appendix E. Post-Analysis Estimates of Power to Detect Effects........................ 164
Abt Associates, Inc. Appendix A 1

1. Appendix A. Note Concerning Results from

Preliminary Analyses

The document you are reading presents final analysis results. A preliminary draft of this

document exists that presents results of preliminary analyses. The preliminary analyses

differ from the final analyses in that seven records that were included in the preliminary

data set were omitted from the data set used in the final analysis. The reason for the

omission of the seven records was a late discovery that the seven omitted children had

conditions that made them ineligible for inclusion in the study. A comparison of results

presented in the preliminary draft and final technical report will show that practically

every number in every table changed at least a small amount after the omission of the

seven subjects. However, the omission of the seven subjects from the final data set did

not change the conclusions. A comparison of the executive summaries of the preliminary

draft and final technical report will show that the conclusions that we draw from both sets

analyses are the same.
Abt Associates, Inc. Appendix B 2

2. Appendix B: Full Detail of Results from Model 1

This appendix presents the full detail of results of fitting Model 1 to the data. The results

shown in this appendix include the parameter estimates corresponding to all covariates,

the model r-square, and the root mean squared error (residual variance)1. Those details

are not available in the model summaries presented in Volume 1 of the technical report.

Since the full detail requires almost a full page of output per outcome measure, and there

were 42 outcome measures, we have elected to show the full output only for Model 1.

However, the parameter estimates corresponding to each covariate, the r-squares, and the

root mean squared error are quite similar across all of the models. Model 1 was of the

form:

Model (1) Specification: Main Effects of Prenatal, and Cumulative Exposures from Birth to

7 Months

             

l

j k l l

k

j k k

j

j j Y preNatThimer Exp07mos oe cf St 0 1 2

: 0 : 0

: 0 : 0

0 2 2

0 1 1

 

 

 

 

a

a

H vs H

H vs H

For further details on the specification and interpretation of this model see Section 9.2.2.2

and Chapter 8.

List of Appendix B Exhibits Page

Speech and Language

Exhibit B.1. Boston Naming Test 4

Exhibit B.2. NEPSY: Speeded Naming 5

Exhibit B.3. NEPSY: Comprehension of Instructions 6

Exhibit B.4. CELF: Formulated Sentences 7

Exhibit B.5. CELF: Recalling Sentences 8

Exhibit B.6. GFTA: Articulation (lower = better) 9

Exhibit B.7. Stuttering: Assessor Rating (lower = better) 10

Exhibit B.8. Stuttering: Parent Rating (lower = better) 11

Exhibit B.9. Stuttering: Teacher Rating (lower = better) 12

Verbal Memory

Exhibit B.10. CVLT-C: Free Recall, No Delay 13

Exhibit B.11. CVLT-C: Free Recall, Short Delay 14

Exhibit B.12. CVLT-C: Cued Recall, Short Delay 15

1

For logistic models, other model fit statistics are provided.
Abt Associates, Inc. Appendix B 3

List of Appendix B Exhibits Page

Exhibit B.13. CVLT-C: Free Recall, Long Delay 16

Exhibit B.14. CVLT-C: Cued Recall, Long Delay 17

Exhibit B.15. CMS Stories 1: Immediate Recall 18

Exhibit B.16. CMS Stories 2: Delayed Recall 19

Achievement

Exhibit B.17. WJIII: Letter- Word Identification 20

Fine Motor Coordination

Exhibit B.18. Grooved Pegboard: Dominant Hand (lower = better) 21

Exhibit B.19. Grooved Pegboard: Non-dom Hand (lower = better) 22

Exhibit B.20. Finger Tapping: Dominant Hand 23

Exhibit B.31. Finger Tapping: Non-dominant Hand 24

Visual Spatial Ability

Exhibit B.22. Stanford Binet: Copying 25

Attention/ Executive Functioning

Exhibit B.23. GDS Vigilance Task: Correct Responses 26

Exhibit B.24. GDS Vigilance Task: Errors (lower = better) 27

Exhibit B.25. WISC III: Digit Span, Forward Recall 28

Exhibit B.26. WISC III: Digit Span, Backward Recall 29

Exhibit B.27. WISC III: Digit Span, Combined 30

Exhibit B.28. BRIEF Parent Rating: Metacognition (lower = better) 31

Exhibit B.29. BRIEF Teacher Rating: Metacognition (lower = better) 32

Behavior Regulation (lower = better)

Exhibit B.30. CRS-R: Parent Rating: Hyperactive/Impulsive (lower = better) 33

Exhibit B.31. CRS-R: Teacher Rating: Hyperactive/Impulsive (lower = better) 34

Exhibit B.32. CRS-R: Parent Rating: Inattentive (lower = better) 35

Exhibit B.33. CRS-R: Teacher Rating: Inattentive (lower = better) 36

Exhibit B.34. BRIEF Parent Rating: Behavior Regulation (lower = better) 37

Exhibit B.35. BRIEF Teacher Rating: Behavior Regulation (lower = better) 38

Tics (lower = better)

Exhibit B.36. Motor tics (current): Assessor Rating (lower = better) 39

Exhibit B.37. Phonics tics (current): Assessor Rating (lower = better) 40

Exhibit B.38. Motor tics (current): Parent Rating (lower = better) 41

Exhibit B.39. Phonics tics (current): Parent Rating (lower = better) 42

General Intellectual Functioning

Exhibit B.40. WASI Verbal IQ 43

Exhibit B.41. WASI Performance IQ 44

Exhibit B.42. WASI Full Scale IQ 45
Abt Associates, Inc. Appendix B 4

Exhibit B.1. Boston Naming Test

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

The GLM Procedure

Dependent Variable: Lg_BNameAvRS Boston Naming Raw

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 32 34029.87700 1063.43366 33.28 <.0001

Error 1012 32336.83496 31.95339

Corrected Total 1044 66366.71196

R-Square Coeff Var Root MSE Lg_BNameAvRS Mean

0.512755 14.29288 5.652733 39.54928

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept 13.26384173 B 2.55874663 5.18 <.0001

PreNatThimer 0.03157685 0.02155435 1.46 0.1432

Exp07mos 0.05036176 0.03021654 1.67 0.0959

ChildAge 3.14029140 0.16834791 18.65 <.0001

sexmale -0.27668807 0.36352476 -0.76 0.4468

ChdBWT_Grp 1 -1.79458543 B 0.72209605 -2.49 0.0131

ChdBWT_Grp 2 0.57839207 B 0.50343510 1.15 0.2509

ChdBWT_Grp 3 0.00000000 B . . .

ComputerExpr 0 -1.35656559 B 1.83382910 -0.74 0.4596

ComputerExpr 1 -1.25586857 B 0.36599907 -3.43 0.0006

ComputerExpr 2 0.00000000 B . . .

MomIQ1 1 -4.58212922 B 0.53544159 -8.56 <.0001

MomIQ1 2 -2.49340325 B 0.47117174 -5.29 <.0001

MomIQ1 3 0.00000000 B . . .

HOME_TotalIndex 0.28004612 0.10086004 2.78 0.0056

PctPoverty1 0.13057668 0.07600496 1.72 0.0861

MomEduc 0 -2.16707379 B 0.95016045 -2.28 0.0228

MomEduc 1 -1.35139108 B 0.57735420 -2.34 0.0194

MomEduc 2 -0.99321329 B 0.44300846 -2.24 0.0252

MomEduc 3 0.00000000 B . . .

SingleParent -1.16453521 0.47491967 -2.45 0.0144

Site HMO-A -1.06508096 B 0.78181153 -1.36 0.1734

Site HMO-B -2.23996193 B 0.74474265 -3.01 0.0027

Site HMO-C -0.15893959 B 0.75630451 -0.21 0.8336

Site HMO-D 0.00000000 B . . .

cMedicalHist_1 -1.70680103 1.17488674 -1.45 0.1466

MatAgeCat 1 -3.92178945 B 3.39571193 -1.15 0.2484

MatAgeCat 2 -1.02524961 B 0.71294386 -1.44 0.1507

MatAgeCat 3 0.00000000 B . . .

OlderSibs -2.17130647 0.41110162 -5.28 <.0001

YoungerSibs -1.14642332 0.40474470 -2.83 0.0047

EngOnly 0.57867685 0.39645895 1.46 0.1447

BFMthsCat 0 -2.30914337 B 0.51137450 -4.52 <.0001

BFMthsCat 1 -1.66382407 B 0.42065404 -3.96 <.0001

BFMthsCat 2 0.00000000 B . . .

PreNatFish_1 -1.26417662 0.72040703 -1.75 0.0796

PreNatFillings_1 0.36392898 0.23516162 1.55 0.1220

PreNatlead_1 1.33542867 0.50681670 2.63 0.0085

MatSpeechDel -5.31364038 1.80798731 -2.94 0.0034

MatSTUTTER 2.87951242 1.73055138 1.66 0.0964
Abt Associates, Inc. Appendix B 5

Exhibit B.2. NEPSY Speeded Naming

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: Lg_SpNameAvRS NEPSY Speed Naming Raw

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 46 19980.60523 434.36098 8.87 <.0001

Error 993 48606.45631 48.94910

Corrected Total 1039 68587.06154

R-Square Coeff Var Root MSE Lg_SpNameAvRS Mean

0.291317 25.54493 6.996363 27.38846

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept -78.31532186 B 165.7132326 -0.47 0.6366

PreNatThimer 0.05698564 0.0269089 2.12 0.0344

Exp07mos 0.01046886 0.0382567 0.27 0.7844

ChildAge 25.99248887 55.2242466 0.47 0.6380

sexmale -1.09857494 0.4556445 -2.41 0.0161

ChdBWT_Grp 1 -0.29929651 B 0.9002651 -0.33 0.7396

ChdBWT_Grp 2 0.77113679 B 0.6279252 1.23 0.2197

ChdBWT_Grp 3 0.00000000 B . . .

ComputerExpr 0 -2.46517469 B 2.2829974 -1.08 0.2805

ComputerExpr 1 -0.44239126 B 0.4576485 -0.97 0.3339

ComputerExpr 2 0.00000000 B . . .

MomIQ1 1 -2.47605350 B 0.6729542 -3.68 0.0002

MomIQ1 2 -1.14234777 B 0.5878222 -1.94 0.0523

MomIQ1 3 0.00000000 B . . .

HOME_TotalIndex 0.24014202 0.1264958 1.90 0.0579

PctPoverty1 0.04712537 0.5393311 0.09 0.9304

MomEduc 0 0.96114904 B 1.2123279 0.79 0.4281

MomEduc 1 -0.83829700 B 0.7316522 -1.15 0.2522

MomEduc 2 -0.16345944 B 0.5537258 -0.30 0.7679

MomEduc 3 0.00000000 B . . .

SingleParent -1.05644638 0.6138278 -1.72 0.0855

Site HMO-A -1.08147832 B 0.9890701 -1.09 0.2745

Site HMO-B -1.62471118 B 0.9499549 -1.71 0.0875

Site HMO-C -0.79619912 B 0.9640932 -0.83 0.4091

Site HMO-D 0.00000000 B . . .

MatLangDel -14.67379579 3.5388622 -4.15 <.0001

OlderSibs -1.06097056 0.5174337 -2.05 0.0406

BFMthsCat 0 -1.16932389 B 0.6439213 -1.82 0.0697

BFMthsCat 1 -1.20378251 B 0.5270575 -2.28 0.0226

BFMthsCat 2 0.00000000 B . . .

DayCareHomeImpVal1 -0.31789030 0.1575087 -2.02 0.0438

MatADHD -3.55763896 2.0893364 -1.70 0.0889

PreNatTuna_1 -0.67515297 0.4280837 -1.58 0.1151

PreNatFish_1 -1.33859376 0.9177241 -1.46 0.1450

PreNatOrgMerc_1 0.44551899 0.4903860 0.91 0.3638

cMedicalHist_1 -3.24057573 1.4920607 -2.17 0.0301

PreNatHomePro_1 -0.70951775 1.1791159 -0.60 0.5475

PreNatNicotine_1 0.64464156 0.8648675 0.75 0.4562

IronDef_1 0.98116171 1.5414430 0.64 0.5246

PreNatlead_1 -0.42737036 0.6414262 -0.67 0.5054

MatAgeCat 1 -2.96693886 B 4.2167401 -0.70 0.4818

MatAgeCat 2 -0.89440260 B 0.8902325 -1.00 0.3153

MatAgeCat 3 0.00000000 B . . .

YoungerSibs 0.26622769 0.5143292 0.52 0.6048

PreNatFillings_1 0.10994066 0.2969427 0.37 0.7113

ChildAge2 -2.12285080 6.0865905 -0.35 0.7273

MatSpeechDel -0.95340632 2.4393244 -0.39 0.6960

ChildAge3 0.06325015 0.2219330 0.28 0.7757

PreNatIllDrug -0.53262416 2.2657188 -0.24 0.8142

PreNatAlcohol_1 -0.29025946 0.6428030 -0.45 0.6517

ADHDstimulant -1.05876667 5.1809639 -0.20 0.8381

EngOnly 0.05928041 0.4990834 0.12 0.9055

PctPoverty1_2 -0.00989205 0.0693830 -0.14 0.8867

PctPoverty1_3 0.00043194 0.0023736 0.18 0.8556
Abt Associates, Inc. Appendix B 6

Exhibit B.3. NEPSY: Comprehension of Instructions

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: Lg_CmpInstAvRS NEPSY Comp Instr. Raw

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 46 2077.789737 45.169342 7.24 <.0001

Error 987 6153.722835 6.234775

Corrected Total 1033 8231.512573

R-Square Coeff Var Root MSE Lg_CmpInstAvRS Mean

0.252419 10.58829 2.496953 23.58221

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept 72.88634471 B 59.89765986 1.22 0.2240

PreNatThimer -0.00170198 0.00963411 -0.18 0.8598

Exp07mos -0.01384076 0.01363245 -1.02 0.3102

ChildAge -18.73468706 19.95138368 -0.94 0.3480

sexmale -0.38101058 0.16319723 -2.33 0.0198

ChdBWT_Grp 1 -0.93788963 B 0.32171421 -2.92 0.0036

ChdBWT_Grp 2 -0.09883282 B 0.22462738 -0.44 0.6600

ChdBWT_Grp 3 0.00000000 B . . .

ComputerExpr 0 0.48657578 B 0.81011199 0.60 0.5482

ComputerExpr 1 -0.39181877 B 0.16386797 -2.39 0.0170

ComputerExpr 2 0.00000000 B . . .

MomIQ1 1 -0.95368410 B 0.23831762 -4.00 <.0001

MomIQ1 2 -0.44280267 B 0.21141127 -2.09 0.0365

MomIQ1 3 0.00000000 B . . .

HOME_TotalIndex 0.03573767 0.04588473 0.78 0.4363

PctPoverty1 0.03394969 0.08618562 0.39 0.6937

MomEduc 0 0.36457345 B 0.43391636 0.84 0.4010

MomEduc 1 -0.80400954 B 0.26179794 -3.07 0.0022

MomEduc 2 -0.10833003 B 0.19851375 -0.55 0.5854

MomEduc 3 0.00000000 B . . .

SingleParent -0.30863143 0.21920901 -1.41 0.1595

Site HMO-A -0.66122105 B 0.35510828 -1.86 0.0629

Site HMO-B -1.34091481 B 0.34038544 -3.94 <.0001

Site HMO-C -0.35632597 B 0.34499957 -1.03 0.3019

Site HMO-D 0.00000000 B . . .

cMedicalHist_1 -0.34957214 0.53447432 -0.65 0.5132

OlderSibs -0.25456221 0.18618118 -1.37 0.1718

DayCareCentrImpVal1 0.11065818 0.08045073 1.38 0.1693

DayCareHomeImpVal1 -0.03926991 0.05638960 -0.70 0.4863

BFMthsCat 0 -0.66414771 B 0.23068748 -2.88 0.0041

BFMthsCat 1 -0.55430678 B 0.19011493 -2.92 0.0036

BFMthsCat 2 0.00000000 B . . .

PreNatNicotine_1 0.47282178 0.30831362 1.53 0.1255

PreNatAlcohol_1 -0.24926412 0.22978339 -1.08 0.2783

PreNatTuna_1 -0.12320654 0.15414205 -0.80 0.4243

PreNatFish_1 -0.53996533 0.32361640 -1.67 0.0955

PreNatOrgMerc_1 -0.09278619 0.17365822 -0.53 0.5933

PreNatHomePro_1 -0.25035961 0.42088192 -0.59 0.5521

PreNatFillings_1 0.04987063 0.10589567 0.47 0.6378

PreNatlead_1 0.13402931 0.22967631 0.58 0.5597

PreNatIllDrug -1.15713417 0.84506766 -1.37 0.1712

C5APGARImpVal1 0.23750942 0.16269257 1.46 0.1446

IronDef_1 -0.87097292 0.56180415 -1.55 0.1214

ADHDstimulant -0.89234232 1.83867608 -0.49 0.6276

MatLangDel -2.50338062 1.16289459 -2.15 0.0316

MatADHD -1.54350704 0.74321653 -2.08 0.0381

ChildAge2 2.23612984 2.19784125 1.02 0.3092

ChildAge3 -0.08456667 0.08010472 -1.06 0.2914

PctPoverty1_2 -0.00173183 0.00493053 -0.35 0.7255

MatAgeCat 1 0.49939025 B 1.50500066 0.33 0.7401

MatAgeCat 2 -0.13538721 B 0.32308536 -0.42 0.6753

MatAgeCat 3 0.00000000 B . . .

YoungerSibs 0.05479397 0.18352175 0.30 0.7653

MatSTUTTER -0.28707537 0.76493445 -0.38 0.7075
Abt Associates, Inc. Appendix B 7

Exhibit B.4. CELF Formulated Sentences

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: Lg_FormSentAvRS CELF Form. Sent. Raw

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 32 16072.10381 502.25324 16.58 <.0001

Error 1005 30441.23049 30.28978

Corrected Total 1037 46513.33430

R-Square Coeff Var Root MSE Lg_FormSentAvRS Mean

0.345538 16.80172 5.503615 32.75626

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept -294.1688122 B 129.2939776 -2.28 0.0231

PreNatThimer 0.0206316 0.0210386 0.98 0.3270

Exp07mos -0.0353459 0.0298594 -1.18 0.2368

ChildAge 99.8717662 43.0652155 2.32 0.0206

sexmale -1.3523269 0.3544627 -3.82 0.0001

ChdBWT_Grp 1 -1.2902228 B 0.7023029 -1.84 0.0665

ChdBWT_Grp 2 -0.2915012 B 0.4913627 -0.59 0.5531

ChdBWT_Grp 3 0.0000000 B . . .

ComputerExpr 0 -2.7162028 B 1.7805550 -1.53 0.1275

ComputerExpr 1 -1.2789855 B 0.3582740 -3.57 0.0004

ComputerExpr 2 0.0000000 B . . .

MomIQ1 1 -2.3776226 B 0.5206969 -4.57 <.0001

MomIQ1 2 -0.8929757 B 0.4599295 -1.94 0.0525

MomIQ1 3 0.0000000 B . . .

HOME_TotalIndex 0.2231898 0.0983038 2.27 0.0234

PctPoverty1 0.7962807 0.4160459 1.91 0.0559

MomEduc 0 -0.1022727 B 0.9551492 -0.11 0.9148

MomEduc 1 -0.9644015 B 0.5701448 -1.69 0.0911

MomEduc 2 -0.2315903 B 0.4335640 -0.53 0.5934

MomEduc 3 0.0000000 B . . .

SingleParent -0.5519178 0.4732947 -1.17 0.2438

Site HMO-A -0.0137480 B 0.7672633 -0.02 0.9857

Site HMO-B -0.6987726 B 0.7384662 -0.95 0.3442

Site HMO-C -0.2264769 B 0.7462420 -0.30 0.7616

Site HMO-D 0.0000000 B . . .

cMedicalHist_1 -0.3749213 1.1462229 -0.33 0.7437

OlderSibs -0.8971647 0.3692729 -2.43 0.0153

DayCareCentrImpVal1 0.2929033 0.1771604 1.65 0.0986

EngOnly 0.4415360 0.3881414 1.14 0.2556

BFMthsCat 0 -1.7746478 B 0.4997335 -3.55 0.0004

BFMthsCat 1 -1.3376430 B 0.4124649 -3.24 0.0012

BFMthsCat 2 0.0000000 B . . .

IronDef_1 -2.1187129 1.2053180 -1.76 0.0791

MatLangDel -6.8380665 2.5262935 -2.71 0.0069

MatSTUTTER 2.2505982 1.6394625 1.37 0.1701

ChildAge2 -10.2902098 4.7438472 -2.17 0.0303

ChildAge3 0.3593357 0.1728818 2.08 0.0379

PctPoverty1_2 -0.0800451 0.0540627 -1.48 0.1390

PctPoverty1_3 0.0023580 0.0018571 1.27 0.2045
Abt Associates, Inc. Appendix B 8

Exhibit B.5. CELF Recalling Sentences

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: VM_RecallAvRS CELF Recall Sent Raw

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 31 79114.8819 2552.0930 19.17 <.0001

Error 1012 134706.3594 133.1091

Corrected Total 1043 213821.2414

R-Square Coeff Var Root MSE VM_RecallAvRS Mean

0.370005 25.87636 11.53729 44.58621

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept 474.7469455 B 269.8818473 1.76 0.0789

PreNatThimer 0.0583376 0.0441694 1.32 0.1869

Exp07mos -0.0012758 0.0619430 -0.02 0.9836

ChildAge -158.1731118 89.8948626 -1.76 0.0788

sexmale -2.2218299 0.7366337 -3.02 0.0026

ChdBWT_Grp 1 -2.2631940 B 1.4546415 -1.56 0.1201

ChdBWT_Grp 2 0.8762690 B 1.0286244 0.85 0.3945

ChdBWT_Grp 3 0.0000000 B . . .

MomIQ1 1 -5.0096449 B 1.0963081 -4.57 <.0001

MomIQ1 2 -2.5950611 B 0.9639369 -2.69 0.0072

MomIQ1 3 0.0000000 B . . .

HOME_TotalIndex 0.3621710 0.2048746 1.77 0.0774

PctPoverty1 0.4303716 0.1538895 2.80 0.0053

MomEduc 0 -1.1225375 B 1.9417653 -0.58 0.5633

MomEduc 1 -2.8261947 B 1.1740503 -2.41 0.0163

MomEduc 2 -1.1197988 B 0.9037697 -1.24 0.2156

MomEduc 3 0.0000000 B . . .

SingleParent -0.4088831 0.9596929 -0.43 0.6702

Site HMO-A -4.1651845 B 1.6105310 -2.59 0.0098

Site HMO-B -6.3492629 B 1.5584792 -4.07 <.0001

Site HMO-C -2.6126886 B 1.5758253 -1.66 0.0976

Site HMO-D 0.0000000 B . . .

OlderSibs -1.5075229 0.7746319 -1.95 0.0519

EngOnly 1.7772630 0.8042134 2.21 0.0273

BFMthsCat 0 -5.6728451 B 1.0413507 -5.45 <.0001

BFMthsCat 1 -3.9963418 B 0.8568564 -4.66 <.0001

BFMthsCat 2 0.0000000 B . . .

PreNatAlcohol_1 -1.4078271 1.0169841 -1.38 0.1666

PreNatFish_1 -2.6350368 1.4776522 -1.78 0.0748

PreNatlead_1 3.1533990 1.0453869 3.02 0.0026

C5APGARImpVal1 1.0165340 0.7405143 1.37 0.1701

IronDef_1 -4.6321803 2.5276600 -1.83 0.0672

MatSpeechDel -4.7108007 3.6744741 -1.28 0.2001

MatSTUTTER 5.9556787 3.5264614 1.69 0.0916

MatADHD -5.7106614 3.4043814 -1.68 0.0938

ChildAge2 18.2829053 9.9055123 1.85 0.0652

ChildAge3 -0.6764510 0.3611075 -1.87 0.0613
Abt Associates, Inc. Appendix B 9

Exhibit B.6. GFTA Articulation

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: TC_GFTA_RS Speech Raw Score

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 26 481.776646 18.529871 5.89 <.0001

Error 998 3139.058476 3.145349

Corrected Total 1024 3620.835122

R-Square Coeff Var Root MSE TC_GFTA_RS Mean

0.133057 112.7699 1.773513 1.572683

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept 2.184106199 B 1.30767629 1.67 0.0952

PreNatThimer -0.001681739 0.00677173 -0.25 0.8039

Exp07mos 0.010989318 0.00953203 1.15 0.2492

ChildAge -0.335770021 0.05294890 -6.34 <.0001

sexmale 0.309241850 0.11402936 2.71 0.0068

ChdBWT_Grp 1 0.087190533 B 0.22425276 0.39 0.6975

ChdBWT_Grp 2 -0.066484274 B 0.15922566 -0.42 0.6764

ChdBWT_Grp 3 0.000000000 B . . .

MomIQ1 1 0.675136454 B 0.16298171 4.14 <.0001

MomIQ1 2 0.271325325 B 0.14722860 1.84 0.0656

MomIQ1 3 0.000000000 B . . .

HOME_TotalIndex 0.040888053 0.03162265 1.29 0.1963

PctPoverty1 -0.196711925 0.13486060 -1.46 0.1450

MomEduc 0 0.202327849 B 0.30575873 0.66 0.5083

MomEduc 1 -0.017913800 B 0.18324002 -0.10 0.9221

MomEduc 2 0.181393996 B 0.13976709 1.30 0.1946

MomEduc 3 0.000000000 B . . .

SingleParent 0.348951971 0.15017792 2.32 0.0203

Site HMO-A -0.017356888 B 0.24703215 -0.07 0.9440

Site HMO-B 0.414210254 B 0.23934383 1.73 0.0838

Site HMO-C -0.169760559 B 0.24064098 -0.71 0.4807

Site HMO-D 0.000000000 B . . .

OlderSibs 0.144415023 0.11977698 1.21 0.2282

PreNatAlcohol_1 0.235616771 0.15520587 1.52 0.1293

C5APGARImpVal1 0.156190987 0.11495753 1.36 0.1746

IronDef_1 -0.636392049 0.38769247 -1.64 0.1010

MatLangDel 1.700103087 0.88307927 1.93 0.0545

MatSpeechDel 1.125568971 0.59130094 1.90 0.0573

MatADHD -0.711886401 0.52698986 -1.35 0.1770

PctPoverty1_2 0.025328738 0.01759814 1.44 0.1504

PctPoverty1_3 -0.000869133 0.00060485 -1.44 0.1510
Abt Associates, Inc. Appendix B 10

Exhibit B.7. Stuttering Assessor Rating

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Response Variable St_CAStuttYN Stut CA 0=None/Very Mild, 1=Mild-Severe

Model Fit Statistics

Intercept

Intercept and

Criterion Only Covariates

AIC 308.428 328.905

SC 313.378 442.752

-2 Log L 306.428 282.905

Testing Global Null Hypothesis: BETA=0

Test Chi-Square DF Pr > ChiSq

Likelihood Ratio 23.5223 22 0.3728

Score 24.9441 22 0.2998

Wald 22.2754 22 0.4436

Standard Wald

Parameter DF Estimate Error Chi-Square Pr > ChiSq

Intercept 1 -84.9793 130.8 0.4223 0.5158

PreNatThimer 1 -0.00249 0.0214 0.0136 0.9072

Exp07mos 1 0.0257 0.0328 0.6127 0.4338

ChildAge 1 27.4389 43.5315 0.3973 0.5285

sexmale 1 0.3552 0.3641 0.9517 0.3293

ChdBWT_Grp 1 1 -0.1497 0.5870 0.0650 0.7987

ChdBWT_Grp 2 1 -0.8866 0.4345 4.1635 0.0413

MomIQ1 1 1 -0.4608 0.5256 0.7686 0.3807

MomIQ1 2 1 -0.3168 0.4700 0.4542 0.5003

HOME_TotalIndex 1 0.00850 0.0979 0.0075 0.9308

PctPoverty1 1 -0.9822 0.7444 1.7411 0.1870

MomEduc 1 -0.2365 0.2306 1.0524 0.3050

SingleParent 1 0.1314 0.4393 0.0894 0.7649

Site HMO-A 1 1.1660 1.1200 1.0838 0.2979

Site HMO-B 1 1.0414 1.0874 0.9172 0.3382

Site HMO-C 1 1.1291 1.0674 1.1191 0.2901

ChildAge2 1 -3.0005 4.7954 0.3915 0.5315

ChildAge3 1 0.1082 0.1748 0.3832 0.5359

PctPoverty1_2 1 0.1814 0.1614 1.2632 0.2611

PctPoverty1_3 1 -0.0101 0.0103 0.9722 0.3241

MatSTUTTER 1 2.0608 0.8463 5.9296 0.0149

PreNatAlcohol_1 1 -1.0067 0.9999 1.0137 0.3140

PreNatlead_1 1 -1.0074 0.7536 1.7871 0.1813

Association of Predicted Probabilities and Observed Responses

Percent Concordant 69.7 Somers' D 0.417

Percent Discordant 28.0 Gamma 0.427

Percent Tied 2.3 Tau-a 0.027

Pairs 35280 c 0.709
Abt Associates, Inc. Appendix B 11

Exhibit B.8. Stuttering Parent Rating

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Response Variable St_PStuttYN Stut Parent 0=None/Very Mild, 1=Mild-Severe

Model Fit Statistics

Intercept

Intercept and

Criterion Only Covariates

AIC 237.555 228.995

SC 242.497 308.069

-2 Log L 235.555 196.995

Testing Global Null Hypothesis: BETA=0

Test Chi-Square DF Pr > ChiSq

Likelihood Ratio 38.5606 15 0.0007

Score 39.5563 15 0.0005

Wald 30.3583 15 0.0107

Standard Wald

Parameter DF Estimate Error Chi-Square Pr > ChiSq

Intercept 1 0.6378 2.7914 0.0522 0.8193

PreNatThimer 1 -0.0243 0.0484 0.2511 0.6163

Exp07mos 1 0.0198 0.0428 0.2142 0.6435

ChildAge 1 -0.1677 0.2027 0.6845 0.4080

sexmale 1 0.4412 0.4372 1.0184 0.3129

ChdBWT_Grp 1 1 -1.4497 0.8526 2.8908 0.0891

ChdBWT_Grp 2 1 -1.4775 0.4726 9.7754 0.0018

MomIQ1 1 1 -0.1301 0.6683 0.0379 0.8456

MomIQ1 2 1 -0.1366 0.6260 0.0476 0.8273

HOME_TotalIndex 1 -0.0851 0.1126 0.5719 0.4495

PctPoverty1 1 0.0742 0.0798 0.8649 0.3524

MomEduc 1 -0.6189 0.2631 5.5330 0.0187

SingleParent 1 -0.2470 0.5897 0.1754 0.6753

Site HMO-A 1 -1.5606 1.1142 1.9616 0.1613

Site HMO-B 1 0.5187 0.8507 0.3717 0.5421

Site HMO-C 1 -1.9090 1.2475 2.3419 0.1259

Association of Predicted Probabilities and Observed Responses

Percent Concordant 81.5 Somers' D 0.646

Percent Discordant 16.9 Gamma 0.657

Percent Tied 1.6 Tau-a 0.031

Pairs 25250 c 0.823
Abt Associates, Inc. Appendix B 12

Exhibit B.9. Stuttering Teacher Rating

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Response Variable St_TStuttYN Stut Teacher 0=None/Very Mild, 1=Mild-Severe

Model Fit Statistics

Intercept

Intercept and

Criterion Only Covariates

AIC 440.084 440.791

SC 444.675 550.958

-2 Log L 438.084 392.791

Testing Global Null Hypothesis: BETA=0

Test Chi-Square DF Pr > ChiSq

Likelihood Ratio 45.2938 23 0.0037

Score 44.9569 23 0.0040

Wald 37.4822 23 0.0289

Standard Wald

Parameter DF Estimate Error Chi-Square Pr > ChiSq

Intercept 1 -5.3379 2.1090 6.4060 0.0114

PreNatThimer 1 -0.0417 0.0296 1.9781 0.1596

Exp07mos 1 0.0105 0.0251 0.1767 0.6742

ChildAge 1 0.00315 0.1335 0.0006 0.9812

sexmale 1 0.6361 0.2907 4.7901 0.0286

ChdBWT_Grp 1 1 -0.2577 0.6215 0.1718 0.6785

ChdBWT_Grp 2 1 0.1120 0.4096 0.0748 0.7845

MomIQ1 1 1 0.1293 0.3829 0.1140 0.7357

MomIQ1 2 1 -0.0312 0.3659 0.0073 0.9321

HOME_TotalIndex 1 -0.0583 0.0758 0.5924 0.4415

PctPoverty1 1 0.8247 0.3854 4.5788 0.0324

MomEduc 1 -0.1387 0.1843 0.5663 0.4518

SingleParent 1 0.0419 0.3765 0.0124 0.9114

Site HMO-A 1 1.1728 1.0716 1.1979 0.2737

Site HMO-B 1 1.6493 1.0552 2.4428 0.1181

Site HMO-C 1 1.0845 1.0710 1.0254 0.3112

cMedicalHist_1 1 1.9016 0.6875 7.6520 0.0057

PctPoverty1_2 1 -0.1102 0.0513 4.6185 0.0316

PctPoverty1_3 1 0.00363 0.00167 4.7294 0.0297

ComputerExpr 1 0.3975 0.2806 2.0073 0.1565

MatLangDel 1 2.1954 1.3372 2.6952 0.1007

PreNatAlcohol_1 1 0.7872 0.3345 5.5371 0.0186

PreNatFish_1 1 -1.5721 1.0304 2.3275 0.1271

YoungerSibs 1 -0.5900 0.3088 3.6500 0.0561

Association of Predicted Probabilities and Observed Responses

Percent Concordant 71.7 Somers' D 0.442

Percent Discordant 27.5 Gamma 0.446

Percent Tied 0.8 Tau-a 0.072

Pairs 43095 c 0.721
Abt Associates, Inc. Appendix B 13

Exhibit B.10. CVLT-C: Free Recall, No Delay

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: VM_ListAAvRS CVLT-C List A

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 43 24873.56236 578.45494 7.92 <.0001

Error 1002 73189.77607 73.04369

Corrected Total 1045 98063.33843

R-Square Coeff Var Root MSE VM_ListAAvRS Mean

0.253648 18.37479 8.546560 46.51243

Standard

Parameter Estimate Error t Value Pr > |t|

Exp07mos -0.0014601 0.0463218 -0.03 0.9749

ChildAge 40.0396472 67.0656506 0.60 0.5506

sexmale -2.7960804 0.5520300 -5.07 <.0001

ChdBWT_Grp 1 -0.0289279 B 1.0942747 -0.03 0.9789

ChdBWT_Grp 2 0.8375671 B 0.7642235 1.10 0.2734

ChdBWT_Grp 3 0.0000000 B . . .

ComputerExpr 0 -3.9816622 B 2.7899981 -1.43 0.1539

ComputerExpr 1 0.2025319 B 0.5587695 0.36 0.7171

ComputerExpr 2 0.0000000 B . . .

MomIQ1 1 -1.2252718 B 0.8176679 -1.50 0.1343

MomIQ1 2 -1.3278792 B 0.7182360 -1.85 0.0648

MomIQ1 3 0.0000000 B . . .

HOME_TotalIndex 0.0254206 0.1529476 0.17 0.8680

PctPoverty1 -0.0874369 0.1156620 -0.76 0.4498

MomEduc 0 0.7389514 B 1.4540728 0.51 0.6114

MomEduc 1 -1.1172077 B 0.8841993 -1.26 0.2067

MomEduc 2 -0.1541189 B 0.6752065 -0.23 0.8195

MomEduc 3 0.0000000 B . . .

SingleParent -0.4407390 0.7356496 -0.60 0.5492

Site HMO-A -1.7649713 B 1.2025156 -1.47 0.1425

Site HMO-B -2.0314219 B 1.1559289 -1.76 0.0792

Site HMO-C -1.7804534 B 1.1698760 -1.52 0.1283

Site HMO-D 0.0000000 B . . .

cMedicalHist_1 -3.9756126 1.7887773 -2.22 0.0265

OlderSibs 0.0420325 0.6291971 0.07 0.9468

YoungerSibs 0.4092631 0.6022305 0.68 0.4969

EngOnly -0.9365292 0.6073030 -1.54 0.1234

BFMthsCat 0 -2.2343974 B 0.7834515 -2.85 0.0044

BFMthsCat 1 -0.4658447 B 0.6429206 -0.72 0.4689

BFMthsCat 2 0.0000000 B . . .

PreNatNicotine_1 -1.1896030 1.0541051 -1.13 0.2594

PreNatAlcohol_1 -0.8912145 0.7816746 -1.14 0.2545

PreNatFish_1 -0.8661441 1.0910622 -0.79 0.4275

PreNatOrgMerc_1 0.4548557 0.5938518 0.77 0.4439

PreNatHomePro_1 1.9664834 1.4422216 1.36 0.1730

PreNatFillings_1 0.5688949 0.3593613 1.58 0.1137

PreNatlead_1 1.0034697 0.7798818 1.29 0.1985

PreNatIllDrug 1.8539007 2.7672795 0.67 0.5031

C5APGARImpVal1 1.2197863 0.5513071 2.21 0.0272

IronDef_1 -1.3382919 1.8805642 -0.71 0.4769

ChdPICA_1 -2.4476328 1.3510224 -1.81 0.0703

MatLangDel -14.7323196 4.2674976 -3.45 0.0006

MatSpeechDel -3.1253598 2.9733547 -1.05 0.2935

MatSTUTTER 3.2990484 2.6285833 1.26 0.2097

ChildAge2 -3.4766808 7.3908544 -0.47 0.6382

ChildAge3 0.1073600 0.2694583 0.40 0.6904

DayCareHomeImpVal1 0.0034352 0.1922330 0.02 0.9857

DayCareCentrImpVal1 -0.1926815 0.2749624 -0.70 0.4836
Abt Associates, Inc. Appendix B 14

Exhibit B.11. CVLT-C: Free Recall, Short Delay

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: VM_ShortFreeAvRS CVLT-C Short/Free Raw

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 26 1630.716668 62.719872 10.45 <.0001

Error 1020 6123.789540 6.003715

Corrected Total 1046 7754.506208

R-Square Coeff Var Root MSE VM_ShortFreeAvRS Mean

0.210293 25.18317 2.450248 9.729704

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept -10.22350914 B 6.04514299 -1.69 0.0911

PreNatThimer -0.00132494 0.00935569 -0.14 0.8874

Exp07mos -0.02396012 0.01301597 -1.84 0.0659

ChildAge 3.64307351 1.31837024 2.76 0.0058

sexmale -0.80564230 0.15628193 -5.16 <.0001

ChdBWT_Grp 1 -0.22525888 B 0.31117060 -0.72 0.4693

ChdBWT_Grp 2 0.13367297 B 0.21747060 0.61 0.5389

ChdBWT_Grp 3 0.00000000 B . . .

MomIQ1 1 -0.17121820 B 0.22440066 -0.76 0.4456

MomIQ1 2 -0.10233292 B 0.20110663 -0.51 0.6110

MomIQ1 3 0.00000000 B . . .

HOME_TotalIndex 0.04122073 0.04341280 0.95 0.3426

PctPoverty1 0.10837933 0.08130346 1.33 0.1828

MomEduc 0 -0.18056989 B 0.41431359 -0.44 0.6631

MomEduc 1 -0.05600533 B 0.24951602 -0.22 0.8224

MomEduc 2 -0.19329619 B 0.19037729 -1.02 0.3102

MomEduc 3 0.00000000 B . . .

SingleParent -0.44998996 0.20555349 -2.19 0.0288

Site HMO-A -0.47960977 B 0.33317373 -1.44 0.1503

Site HMO-B -0.26552857 B 0.32026960 -0.83 0.4073

Site HMO-C -0.12753643 B 0.32396497 -0.39 0.6939

Site HMO-D 0.00000000 B . . .

cMedicalHist_1 -1.32294083 0.50920389 -2.60 0.0095

EngOnly -0.53340190 0.17020715 -3.13 0.0018

PreNatTuna_1 -0.19733320 0.14590768 -1.35 0.1765

PreNatlead_1 0.43928421 0.21838134 2.01 0.0445

MatLangDel -4.40686621 1.11073964 -3.97 <.0001

ChildAge2 -0.14592623 0.07184216 -2.03 0.0425

PctPoverty1_2 -0.00760962 0.00470424 -1.62 0.1061

PreNatAlcohol_1 -0.14930585 0.21426407 -0.70 0.4861

DayCareHomeImpVal1 -0.04615687 0.05396560 -0.86 0.3926
Abt Associates, Inc. Appendix B 15

Exhibit B.12. CVLT-C: Cued Recall, Short Delay

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: VM_ShortCueAvRS CVLT-C Short/Cued Raw

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 27 1366.503674 50.611247 11.13 <.0001

Error 1017 4625.146087 4.547833

Corrected Total 1044 5991.649761

R-Square Coeff Var Root MSE VM_ShortCueAvRS Mean

0.228068 20.70355 2.132565 10.30048

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept -6.013391672 B 5.49333986 -1.09 0.2739

PreNatThimer -0.000914404 0.00808648 -0.11 0.9100

Exp07mos -0.005348102 0.01139559 -0.47 0.6389

ChildAge 2.431741176 1.14755922 2.12 0.0343

sexmale -0.935770174 0.13612686 -6.87 <.0001

ChdBWT_Grp 1 -0.141917935 B 0.27126098 -0.52 0.6010

ChdBWT_Grp 2 0.282275839 B 0.18995550 1.49 0.1376

ChdBWT_Grp 3 0.000000000 B . . .

MomIQ1 1 -0.535271086 B 0.19534969 -2.74 0.0063

MomIQ1 2 -0.652892185 B 0.17586999 -3.71 0.0002

MomIQ1 3 0.000000000 B . . .

HOME_TotalIndex 0.031186644 0.03746888 0.83 0.4054

PctPoverty1 0.034546063 0.02865502 1.21 0.2283

MomEduc 0 0.350289890 B 0.35608300 0.98 0.3255

MomEduc 1 0.188231291 B 0.21634517 0.87 0.3845

MomEduc 2 0.104683464 B 0.16620288 0.63 0.5289

MomEduc 3 0.000000000 B . . .

SingleParent -0.051954422 0.17918336 -0.29 0.7719

Site HMO-A -0.357187785 B 0.29121091 -1.23 0.2203

Site HMO-B -0.260549824 B 0.27920044 -0.93 0.3509

Site HMO-C -0.014797193 B 0.28199885 -0.05 0.9582

Site HMO-D 0.000000000 B . . .

cMedicalHist_1 -1.085451218 0.44347356 -2.45 0.0145

OlderSibs 0.235389207 0.15498663 1.52 0.1291

YoungerSibs 0.302694003 0.14971292 2.02 0.0435

DayCareHomeImpVal1 -0.074461833 0.04728739 -1.57 0.1156

EngOnly -0.222527896 0.14778227 -1.51 0.1324

PreNatHomePro_1 0.595804995 0.35253497 1.69 0.0913

C5APGARImpVal1 0.187202913 0.13681798 1.37 0.1715

MatLangDel -2.569128679 1.05441660 -2.44 0.0150

MatSpeechDel -1.187527734 0.71062708 -1.67 0.0950

ChildAge2 -0.086257924 0.06254121 -1.38 0.1681
Abt Associates, Inc. Appendix B 16

Exhibit B.13. CVLT-C: Free Recall, Long Delay

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: VM_LongFreeAvRS CVLT-C Long /Free Raw

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 33 1531.391040 46.405789 9.14 <.0001

Error 1010 5128.851134 5.078070

Corrected Total 1043 6660.242174

R-Square Coeff Var Root MSE VM_LongFreeAvRS Mean

0.229930 21.70484 2.253457 10.38228

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept -7.596713867 B 5.81898944 -1.31 0.1920

PreNatThimer 0.000895765 0.00858354 0.10 0.9169

Exp07mos -0.019361223 0.01204991 -1.61 0.1084

ChildAge 2.954670870 1.21697627 2.43 0.0154

sexmale -0.915895568 0.14451900 -6.34 <.0001

ChdBWT_Grp 1 -0.330076151 B 0.28753109 -1.15 0.2513

ChdBWT_Grp 2 0.198244243 B 0.20057619 0.99 0.3232

ChdBWT_Grp 3 0.000000000 B . . .

MomIQ1 1 -0.288308823 B 0.21259978 -1.36 0.1754

MomIQ1 2 -0.285246682 B 0.18814713 -1.52 0.1298

MomIQ1 3 0.000000000 B . . .

HOME_TotalIndex -0.001388907 0.04022558 -0.03 0.9725

PctPoverty1 0.123308303 0.07718701 1.60 0.1105

MomEduc 0 -0.035427132 B 0.38218000 -0.09 0.9262

MomEduc 1 -0.082356169 B 0.23243989 -0.35 0.7232

MomEduc 2 -0.170383501 B 0.17658558 -0.96 0.3348

MomEduc 3 0.000000000 B . . .

SingleParent 0.061069068 0.19553692 0.31 0.7549

Site HMO-A -0.236554785 B 0.30927892 -0.76 0.4445

Site HMO-B -0.222943355 B 0.29659287 -0.75 0.4524

Site HMO-C -0.011421889 B 0.30060307 -0.04 0.9697

Site HMO-D 0.000000000 B . . .

cMedicalHist_1 -1.342397219 0.48212710 -2.78 0.0055

YoungerSibs 0.410133456 0.14821523 2.77 0.0058

DayCareCentrImpVal1 -0.116030664 0.07205770 -1.61 0.1077

DayCareHomeImpVal1 -0.105037534 0.05034330 -2.09 0.0372

EngOnly -0.349722640 0.15839800 -2.21 0.0275

PreNatTuna_1 -0.191825599 0.13510883 -1.42 0.1560

PreNatOrgMerc_1 0.272879178 0.15545040 1.76 0.0795

PreNatHomePro_1 0.635003766 0.37474200 1.69 0.0905

PreNatlead_1 0.328514276 0.20321226 1.62 0.1063

C5APGARImpVal1 0.197623064 0.14486259 1.36 0.1728

ADHDstimulant -2.668081874 1.61096950 -1.66 0.0980

MatLangDel -5.287765928 1.02616058 -5.15 <.0001

ChildAge2 -0.114980359 0.06631638 -1.73 0.0833

PctPoverty1_2 -0.006633540 0.00442267 -1.50 0.1340

BFMthsCat 0 -0.163820652 B 0.20383899 -0.80 0.4218

BFMthsCat 1 0.145140955 B 0.16882125 0.86 0.3901

BFMthsCat 2 0.000000000 B . . .
Abt Associates, Inc. Appendix B 17

Exhibit B.14. CVLT-C: Cued Recall, Long Delay

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: VM_LongCueAvRS CVLT-C Long /Cued Raw

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 49 1582.692548 32.299848 6.76 <.0001

Error 993 4743.171306 4.776608

Corrected Total 1042 6325.863854

R-Square Coeff Var Root MSE VM_LongCueAvRS Mean

0.250194 20.52515 2.185545 10.64813

Parameter Estimate Stand.Error t Value Pr > |t|

Intercept -14.31151450 B 51.77926534 -0.28 0.7823

PreNatThimer 0.00481781 0.00842896 0.57 0.5677

Exp07mos 0.00107857 0.01194847 0.09 0.9281

ChildAge 5.04757296 17.25753928 0.29 0.7700

sexmale -0.99505010 0.14214153 -7.00 <.0001

ChdBWT_Grp 1 -0.54282104 B 0.28143379 -1.93 0.0540

ChdBWT_Grp 2 0.16811535 B 0.19633121 0.86 0.3920

ChdBWT_Grp 3 0.00000000 B . . .

ComputerExpr 0 -0.08046415 B 0.71372090 -0.11 0.9103

ComputerExpr 1 0.23215784 B 0.14314051 1.62 0.1051

ComputerExpr 2 0.00000000 B . . .

MomIQ1 1 -0.43724066 B 0.21057464 -2.08 0.0381

MomIQ1 2 -0.57733795 B 0.18382857 -3.14 0.0017

MomIQ1 3 0.00000000 B . . .

HOME_TotalIndex -0.00219414 0.03949204 -0.06 0.9557

PctPoverty1 0.03755111 0.16809320 0.22 0.8233

MomEduc 0 0.10460954 B 0.38044074 0.27 0.7834

MomEduc 1 -0.05179932 B 0.22863064 -0.23 0.8208

MomEduc 2 -0.00434358 B 0.17323122 -0.03 0.9800

MomEduc 3 0.00000000 B . . .

SingleParent 0.15067701 0.19342940 0.78 0.4362

Site HMO-A -0.42117030 B 0.30908842 -1.36 0.1733

Site HMO-B -0.25555154 B 0.29732616 -0.86 0.3903

Site HMO-C -0.22264102 B 0.30112027 -0.74 0.4599

Site HMO-D 0.00000000 B . . .

cMedicalHist_1 -1.27965136 0.46876335 -2.73 0.0064

MatAgeCat 1 -1.80895472 B 1.31807637 -1.37 0.1702

MatAgeCat 2 -0.09961466 B 0.27754203 -0.36 0.7197

MatAgeCat 3 0.00000000 B . . .

YoungerSibs 0.41623627 0.15997669 2.60 0.0094

DayCareCentrImpVal1 -0.12163182 0.07069385 -1.72 0.0856

DayCareHomeImpVal1 -0.08978717 0.04933409 -1.82 0.0691

EngOnly -0.21986374 0.15664611 -1.40 0.1608

PreNatAlcohol_1 -0.20392381 0.20098568 -1.01 0.3105

PreNatTuna_1 -0.20744451 0.13378156 -1.55 0.1213

PreNatFish_1 0.33285835 0.28521176 1.17 0.2435

PreNatOrgMerc_1 0.20878834 0.15226501 1.37 0.1706

PreNatHomePro_1 0.50670651 0.36836178 1.38 0.1693

PreNatFillings_1 0.07535705 0.09241557 0.82 0.4150

PreNatlead_1 0.22414587 0.20044561 1.12 0.2637

PreNatIllDrug 0.68768231 0.70782278 0.97 0.3315

C5APGARImpVal1 0.11604524 0.14160926 0.82 0.4127

ADHDstimulant -2.33507689 1.63927324 -1.42 0.1546

MatLangDel -2.90852545 1.10884245 -2.62 0.0088

MatSTUTTER 0.36591554 0.68211065 0.54 0.5918

MatADHD -0.34119490 0.65308934 -0.52 0.6015

IronDef_1 -0.23572296 0.48217446 -0.49 0.6250

ChildAge2 -0.30102541 1.90193051 -0.16 0.8743

ChildAge3 0.00529197 0.06934424 0.08 0.9392

OlderSibs 0.01863494 0.16223243 0.11 0.9086

BFMthsCat 0 -0.08093778 B 0.20186775 -0.40 0.6885

BFMthsCat 1 -0.00135962 B 0.16596848 -0.01 0.9935

BFMthsCat 2 0.00000000 B . . .

PreNatNicotine_1 -0.00362278 0.27200918 -0.01 0.9894

MatSpeechDel -0.12384504 0.77679536 -0.16 0.8734

PctPoverty1_2 0.00316573 0.02165587 0.15 0.8838

PctPoverty1_3 -0.00031250 0.00074148 -0.42 0.6735
Abt Associates, Inc. Appendix B 18

Exhibit B.15. CMS Stories 1: Immediate Recall

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: VM_CMS1AvRS CMS Stories 1(Immed) Raw

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 27 126410.6776 4681.8769 38.51 <.0001

Error 1010 122799.7203 121.5839

Corrected Total 1037 249210.3979

R-Square Coeff Var Root MSE VM_CMS1AvRS Mean

0.507245 23.28359 11.02651 47.35742

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept 1953.076109 B 258.5935106 7.55 <.0001

PreNatThimer 0.023843 0.0419105 0.57 0.5695

Exp07mos -0.030354 0.0595439 -0.51 0.6103

ChildAge -662.714977 86.1364286 -7.69 <.0001

sexmale -3.093166 0.7072651 -4.37 <.0001

ChdBWT_Grp 1 -2.969500 B 1.3898014 -2.14 0.0329

ChdBWT_Grp 2 -0.213248 B 0.9770122 -0.22 0.8273

ChdBWT_Grp 3 0.000000 B . . .

ComputerExpr 0 -1.899474 B 3.5571524 -0.53 0.5935

ComputerExpr 1 -1.542068 B 0.7148328 -2.16 0.0312

ComputerExpr 2 0.000000 B . . .

MomIQ1 1 -3.428001 B 1.0253513 -3.34 0.0009

MomIQ1 2 -1.622536 B 0.9216070 -1.76 0.0786

MomIQ1 3 0.000000 B . . .

HOME_TotalIndex 0.388969 0.1964414 1.98 0.0480

PctPoverty1 -0.061799 0.1501822 -0.41 0.6808

MomEduc 0 1.806169 B 1.8550476 0.97 0.3305

MomEduc 1 -1.167612 B 1.1299182 -1.03 0.3017

MomEduc 2 -0.600786 B 0.8631245 -0.70 0.4866

MomEduc 3 0.000000 B . . .

SingleParent -1.562557 0.9259803 -1.69 0.0918

Site HMO-A -4.679599 B 1.5227492 -3.07 0.0022

Site HMO-B -4.453381 B 1.4538026 -3.06 0.0022

Site HMO-C -3.079320 B 1.4735370 -2.09 0.0369

Site HMO-D 0.000000 B . . .

OlderSibs -1.832498 0.7406126 -2.47 0.0135

DayCareCentrImpVal1 0.572185 0.3557618 1.61 0.1081

BFMthsCat 0 -2.845365 B 0.9957555 -2.86 0.0044

BFMthsCat 1 -2.412854 B 0.8265535 -2.92 0.0036

BFMthsCat 2 0.000000 B . . .

PreNatlead_1 1.408112 0.9947865 1.42 0.1572

MatLangDel -10.310075 5.0088040 -2.06 0.0398

ChildAge2 75.155577 9.4911921 7.92 <.0001

ChildAge3 -2.776798 0.3459877 -8.03 <.0001
Abt Associates, Inc. Appendix B 19

Exhibit B.16. CMS Stories 2: Delayed Recall

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: VM_CMS2AvRS CMS Stories 2(Delay) Raw

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 34 118709.0808 3491.4436 29.88 <.0001

Error 1002 117090.0995 116.8564

Corrected Total 1036 235799.1803

R-Square Coeff Var Root MSE VM_CMS2AvRS Mean

0.503433 24.29664 10.81001 44.49180

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept 1961.311544 B 254.8375869 7.70 <.0001

PreNatThimer -0.009564 0.0413032 -0.23 0.8169

Exp07mos 0.004714 0.0587667 0.08 0.9361

ChildAge -665.791943 84.8867162 -7.84 <.0001

sexmale -3.315430 0.6944496 -4.77 <.0001

ChdBWT_Grp 1 -2.790834 B 1.3752291 -2.03 0.0427

ChdBWT_Grp 2 0.183150 B 0.9675412 0.19 0.8499

ChdBWT_Grp 3 0.000000 B . . .

MomIQ1 1 -2.885325 B 1.0278195 -2.81 0.0051

MomIQ1 2 -1.210361 B 0.9085137 -1.33 0.1831

MomIQ1 3 0.000000 B . . .

HOME_TotalIndex 0.376884 0.1939425 1.94 0.0523

PctPoverty1 0.508976 0.8251902 0.62 0.5375

MomEduc 0 0.951870 B 1.8615181 0.51 0.6092

MomEduc 1 -0.944872 B 1.1206516 -0.84 0.3993

MomEduc 2 -0.176504 B 0.8518636 -0.21 0.8359

MomEduc 3 0.000000 B . . .

SingleParent -2.363545 0.9299242 -2.54 0.0112

Site HMO-A -4.711437 B 1.5195362 -3.10 0.0020

Site HMO-B -4.409562 B 1.4665561 -3.01 0.0027

Site HMO-C -3.773711 B 1.4855363 -2.54 0.0112

Site HMO-D 0.000000 B . . .

OlderSibs -1.421518 0.7312106 -1.94 0.0522

DayCareCentrImpVal1 0.544752 0.3521912 1.55 0.1222

DayCareHomeImpVal1 0.456241 0.2424151 1.88 0.0601

BFMthsCat 0 -3.661178 B 0.9835388 -3.72 0.0002

BFMthsCat 1 -2.375565 B 0.8144507 -2.92 0.0036

BFMthsCat 2 0.000000 B . . .

PreNatlead_1 1.066551 0.9817825 1.09 0.2776

IronDef_1 -3.887856 2.3715352 -1.64 0.1014

MatLangDel -9.445936 5.0130705 -1.88 0.0598

ChildAge2 75.340996 9.3533722 8.05 <.0001

ChildAge3 -2.779912 0.3409594 -8.15 <.0001

MatSTUTTER -2.954084 3.2240427 -0.92 0.3597

PreNatOrgMerc_1 -0.689785 0.7525882 -0.92 0.3596

EngOnly 0.673074 0.7627630 0.88 0.3778

MatADHD -2.487915 3.2149382 -0.77 0.4392

PreNatFish_1 0.454147 1.3851747 0.33 0.7431

PctPoverty1_2 -0.044192 0.1072619 -0.41 0.6804

PctPoverty1_3 0.000816 0.0036756 0.22 0.8244
Abt Associates, Inc. Appendix B 20

Exhibit B.17. WJIII: Letter- Word Identification

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: Rd_LWIDAvRS WJIII Letter Word Raw

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 33 44498.87891 1348.45088 28.78 <.0001

Error 1009 47278.34065 46.85663

Corrected Total 1042 91777.21956

R-Square Coeff Var Root MSE Rd_LWIDAvRS Mean

0.484858 13.44748 6.845190 50.90316

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept -184.5901328 B 160.7751796 -1.15 0.2512

PreNatThimer 0.0109867 0.0261918 0.42 0.6750

Exp07mos 0.0618545 0.0369485 1.67 0.0944

ChildAge 62.7391932 53.5556710 1.17 0.2417

sexmale -0.4489010 0.4409063 -1.02 0.3089

ChdBWT_Grp 1 -1.7503410 B 0.8642832 -2.03 0.0431

ChdBWT_Grp 2 -0.1529597 B 0.6113135 -0.25 0.8025

ChdBWT_Grp 3 0.0000000 B . . .

ComputerExpr 0 -3.3841786 B 2.2242201 -1.52 0.1284

ComputerExpr 1 -1.8319612 B 0.4449616 -4.12 <.0001

ComputerExpr 2 0.0000000 B . . .

MomIQ1 1 -3.1765776 B 0.6465641 -4.91 <.0001

MomIQ1 2 -2.1835385 B 0.5722752 -3.82 0.0001

MomIQ1 3 0.0000000 B . . .

HOME_TotalIndex -0.0209715 0.1227437 -0.17 0.8644

PctPoverty1 0.3845906 0.2352300 1.63 0.1024

MomEduc 0 -2.3022238 B 1.1634542 -1.98 0.0481

MomEduc 1 -1.8518292 B 0.7000456 -2.65 0.0083

MomEduc 2 -1.1055317 B 0.5386276 -2.05 0.0404

MomEduc 3 0.0000000 B . . .

SingleParent -1.0018536 0.5852397 -1.71 0.0872

Site HMO-A 0.5435816 B 0.9461896 0.57 0.5658

Site HMO-B -0.8737347 B 0.9074017 -0.96 0.3358

Site HMO-C -1.9152352 B 0.9205387 -2.08 0.0377

Site HMO-D 0.0000000 B . . .

OlderSibs -1.4983837 0.4982102 -3.01 0.0027

YoungerSibs -1.4707352 0.4888584 -3.01 0.0027

EngOnly -1.3541553 0.4808006 -2.82 0.0050

BFMthsCat 0 -1.3873960 B 0.6174067 -2.25 0.0248

BFMthsCat 1 -0.8405679 B 0.5081200 -1.65 0.0984

BFMthsCat 2 0.0000000 B . . .

PreNatAlcohol_1 -1.1828247 0.6022796 -1.96 0.0498

PreNatFish_1 -1.3596364 0.8717437 -1.56 0.1192

PreNatOrgMerc_1 -0.7459730 0.4736313 -1.58 0.1156

PreNatlead_1 1.1284525 0.6232690 1.81 0.0705

MatSpeechDel -6.7355828 2.1177186 -3.18 0.0015

MatADHD -7.3885505 2.0193795 -3.66 0.0003

ChildAge2 -5.5716690 5.9009740 -0.94 0.3453

ChildAge3 0.1749528 0.2151088 0.81 0.4162

PctPoverty1_2 -0.0261021 0.0134885 -1.94 0.0533
Abt Associates, Inc. Appendix B 21

Exhibit B.18. Grooved Pegboard: Dominant Hand (lower = better)

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: FM_PegDAvRS G Pegboard Dom Hand Raw

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 28 505270.2501 18045.3661 64.00 <.0001

Error 1016 286452.8318 281.9418

Corrected Total 1044 791723.0819

R-Square Coeff Var Root MSE FM_PegDAvRS Mean

0.638191 25.48895 16.79112 65.87608

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept 86.32552977 B 9.32336678 9.26 <.0001

PreNatThimer -0.10888833 0.06402764 -1.70 0.0893

Exp07mos -0.07972757 0.08906065 -0.90 0.3709

ChildAge -5.00860076 0.93469598 -5.36 <.0001

Spline9 52.06865137 2.05608487 25.32 <.0001

sexmale 1.46852790 1.07202433 1.37 0.1710

ChdBWT_Grp 1 -1.95410486 B 2.13301508 -0.92 0.3598

ChdBWT_Grp 2 -1.75012952 B 1.49202368 -1.17 0.2411

ChdBWT_Grp 3 0.00000000 B . . .

MomIQ1 1 2.79211453 B 1.58322920 1.76 0.0781

MomIQ1 2 2.61224536 B 1.40045189 1.87 0.0624

MomIQ1 3 0.00000000 B . . .

HOME_TotalIndex -0.62903909 0.29744664 -2.11 0.0347

PctPoverty1 -0.26768936 0.22275313 -1.20 0.2297

MomEduc 0 0.69416858 B 2.81046866 0.25 0.8050

MomEduc 1 0.12874420 B 1.70827444 0.08 0.9399

MomEduc 2 0.53285950 B 1.31280269 0.41 0.6849

MomEduc 3 0.00000000 B . . .

SingleParent 1.24885736 1.39887187 0.89 0.3722

cMedicalHist_1 7.32146446 3.49105257 2.10 0.0362

Site HMO-A -2.25335812 B 2.30204394 -0.98 0.3279

Site HMO-B -1.32044343 B 2.20842857 -0.60 0.5500

Site HMO-C -1.93019447 B 2.23902837 -0.86 0.3889

Site HMO-D 0.00000000 B . . .

DayCareHomeImpVal1 1.16760787 0.37071055 3.15 0.0017

EngOnly 3.30854912 1.17017314 2.83 0.0048

BFMthsCat 0 2.94644862 B 1.50797663 1.95 0.0510

BFMthsCat 1 0.83460295 B 1.24352660 0.67 0.5023

BFMthsCat 2 0.00000000 B . . .

PreNatAlcohol_1 2.18100595 1.46674799 1.49 0.1373

PreNatFish_1 6.10000518 2.13671477 2.85 0.0044

PreNatOrgMerc_1 -1.92765872 1.15661551 -1.67 0.0959

MatLangDel 32.40206631 7.68599505 4.22 <.0001

MatADHD -8.51934275 4.98940126 -1.71 0.0880
Abt Associates, Inc. Appendix B 22

Exhibit B.19. Grooved Pegboard: Non-dom Hand (lower = better)

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: FM_PegNDAvRS G Pegboard NonDom Hand Raw

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 42 641567.427 15275.415 37.79 <.0001

Error 996 402594.798 404.212

Corrected Total 1038 1044162.225

R-Square Coeff Var Root MSE FM_PegNDAvRS Mean

0.614433 27.28167 20.10502 73.69423

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept 393.3746127 B 278.1405173 1.41 0.1576

PreNatThimer -0.0829387 0.0773082 -1.07 0.2836

Exp07mos -0.2737309 0.1092791 -2.50 0.0124

ChildAge -80.7863930 68.7005181 -1.18 0.2399

Spline9 13.6803956 389.7963462 0.04 0.9720

ChildAge_Spline9 25.5739065 87.8665231 0.29 0.7711

ChildAge2 4.7085328 4.2270089 1.11 0.2656

ChildAge2_Spline9 -2.2928002 5.0367416 -0.46 0.6491

sexmale 0.1936617 1.3004153 0.15 0.8816

ChdBWT_Grp 1 0.9456807 B 2.5897128 0.37 0.7151

ChdBWT_Grp 2 0.3381003 B 1.7947317 0.19 0.8506

ChdBWT_Grp 3 0.0000000 B . . .

MomIQ1 1 2.5325129 B 1.9286475 1.31 0.1895

MomIQ1 2 1.2380590 B 1.6907115 0.73 0.4642

MomIQ1 3 0.0000000 B . . .

HOME_TotalIndex -0.8304600 0.3603065 -2.30 0.0214

PctPoverty1 -0.4590885 0.6750885 -0.68 0.4966

MomEduc 0 6.1159480 B 3.4560418 1.77 0.0771

MomEduc 1 3.0928258 B 2.0993672 1.47 0.1410

MomEduc 2 -0.3476799 B 1.5885870 -0.22 0.8268

MomEduc 3 0.0000000 B . . .

SingleParent 2.0406090 1.7308235 1.18 0.2387

Site HMO-A -3.1493059 B 2.7965749 -1.13 0.2604

Site HMO-B -1.8907624 B 2.6692105 -0.71 0.4789

Site HMO-C -1.6139428 B 2.7021436 -0.60 0.5505

Site HMO-D 0.0000000 B . . .

cMedicalHist_1 3.0948603 4.2951348 0.72 0.4714

DayCareHomeImpVal1 0.9754289 0.4514397 2.16 0.0310

EngOnly 3.8813138 1.4397030 2.70 0.0071

BFMthsCat 0 3.9761038 B 1.8502679 2.15 0.0319

BFMthsCat 1 -0.6366776 B 1.5179062 -0.42 0.6750

BFMthsCat 2 0.0000000 B . . .

PreNatNicotine_1 6.3166801 2.4792147 2.55 0.0110

PreNatAlcohol_1 2.4445654 1.8416082 1.33 0.1847

PreNatTuna_1 2.2455927 1.2207603 1.84 0.0661

PreNatOrgMerc_1 -2.4656979 1.3888324 -1.78 0.0761

PreNatHomePro_1 -6.5829997 3.3626818 -1.96 0.0505

PreNatFillings_1 1.2474311 0.8550152 1.46 0.1449

ADHDstimulant 17.9055997 14.8095648 1.21 0.2269

MatLangDel 44.2193573 9.2852032 4.76 <.0001

PreNatIllDrug -9.8965649 6.5081029 -1.52 0.1287

MatAgeCat 1 -3.4308851 B 12.1099993 -0.28 0.7770

MatAgeCat 2 -3.4205205 B 2.5263013 -1.35 0.1761

MatAgeCat 3 0.0000000 B . . .

PctPoverty1_2 0.0247656 0.0389979 0.64 0.5255

OlderSibs -1.0788298 1.3739394 -0.79 0.4325

C5APGARImpVal1 0.8275196 1.3027887 0.64 0.5254

MatSTUTTER -2.5253246 6.1322088 -0.41 0.6806

DayCareCentrImpVal1 -0.1232912 0.6476154 -0.19 0.8491
Abt Associates, Inc. Appendix B 23

Exhibit B.20. Finger Tapping: Dominant Hand

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: FM_TapDAvRS Finger Tap Dom Hand Raw

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 31 14742.03796 475.54961 14.39 <.0001

Error 1005 33206.72083 33.04151

Corrected Total 1036 47948.75878

R-Square Coeff Var Root MSE FM_TapDAvRS Mean

0.307454 14.81136 5.748175 38.80923

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept -17.06354509 B 14.24734494 -1.20 0.2313

PreNatThimer -0.01470163 0.02187587 -0.67 0.5017

Exp07mos 0.03427288 0.03113816 1.10 0.2713

ChildAge 9.83562111 3.09371442 3.18 0.0015

sexmale 2.35935311 0.37107795 6.36 <.0001

ChdBWT_Grp 1 -0.12923475 B 0.73641699 -0.18 0.8607

ChdBWT_Grp 2 0.12087398 B 0.51234929 0.24 0.8135

ChdBWT_Grp 3 0.00000000 B . . .

ComputerExpr 0 -2.33897259 B 1.85878560 -1.26 0.2086

ComputerExpr 1 -1.02985633 B 0.37330287 -2.76 0.0059

ComputerExpr 2 0.00000000 B . . .

MomIQ1 1 -0.09490424 B 0.54255163 -0.17 0.8612

MomIQ1 2 0.29757981 B 0.48171616 0.62 0.5369

MomIQ1 3 0.00000000 B . . .

HOME_TotalIndex -0.22787300 0.10229636 -2.23 0.0261

PctPoverty1 0.07887623 0.07764860 1.02 0.3100

MomEduc 0 -0.38838599 B 0.97304379 -0.40 0.6899

MomEduc 1 -1.25925490 B 0.59224605 -2.13 0.0337

MomEduc 2 -0.09411604 B 0.45253202 -0.21 0.8353

MomEduc 3 0.00000000 B . . .

SingleParent 0.55417887 0.49413630 1.12 0.2623

cMedicalHist_1 -2.23849435 1.19767017 -1.87 0.0619

Site HMO-A 0.24977187 B 0.80460207 0.31 0.7563

Site HMO-B -0.88945409 B 0.77211796 -1.15 0.2496

Site HMO-C -0.92256427 B 0.78180458 -1.18 0.2383

Site HMO-D 0.00000000 B . . .

MatAgeCat 1 2.27983397 B 3.45191989 0.66 0.5091

MatAgeCat 2 1.62137904 B 0.72540669 2.24 0.0256

MatAgeCat 3 0.00000000 B . . .

OlderSibs -0.38694057 0.41993422 -0.92 0.3570

YoungerSibs -0.59075878 0.41346647 -1.43 0.1534

DayCareCentrImpVal1 -0.22966434 0.18384645 -1.25 0.2119

EngOnly -0.75050854 0.40517235 -1.85 0.0643

BFMthsCat 0 -0.10792773 B 0.52176839 -0.21 0.8362

BFMthsCat 1 -1.35360511 B 0.43132309 -3.14 0.0017

BFMthsCat 2 0.00000000 B . . .

MatLangDel -6.80531657 2.63392914 -2.58 0.0099

MatADHD 5.82481967 1.78812737 3.26 0.0012

ChildAge2 -0.38620999 0.16862579 -2.29 0.0222
Abt Associates, Inc. Appendix B 24

Exhibit B.21. Finger Tapping: Non-dominant Hand

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: FM_TapNDAvRS Finger Tap NonDom Hand Raw

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 36 13414.68842 372.63023 13.81 <.0001

Error 997 26905.60575 26.98657

Corrected Total 1033 40320.29417

R-Square Coeff Var Root MSE FM_TapNDAvRS Mean

0.332703 15.07263 5.194860 34.46552

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept -59.06155972 B 122.5935877 -0.48 0.6301

PreNatThimer -0.01488407 0.0199297 -0.75 0.4553

Exp07mos 0.01794495 0.0281831 0.64 0.5244

ChildAge 24.34514389 40.8442350 0.60 0.5513

sexmale 2.68401611 0.3368045 7.97 <.0001

ComputerExpr 0 -2.11322252 B 1.6814451 -1.26 0.2091

ComputerExpr 1 -0.72618587 B 0.3391016 -2.14 0.0325

ComputerExpr 2 0.00000000 B . . .

MomIQ1 1 -0.19166119 B 0.4865952 -0.39 0.6938

MomIQ1 2 0.29950780 B 0.4313424 0.69 0.4876

MomIQ1 3 0.00000000 B . . .

HOME_TotalIndex -0.12381331 0.0931662 -1.33 0.1842

PctPoverty1 0.25106200 0.1788798 1.40 0.1608

MomEduc 0 -0.56592038 B 0.8951568 -0.63 0.5274

MomEduc 1 -0.31279796 B 0.5372587 -0.58 0.5606

MomEduc 2 0.02895940 B 0.4089732 0.07 0.9436

MomEduc 3 0.00000000 B . . .

SingleParent 0.51736727 0.4554781 1.14 0.2563

Site HMO-A 0.03140924 B 0.7276402 0.04 0.9656

Site HMO-B -0.71135124 B 0.6999537 -1.02 0.3097

Site HMO-C -0.78561666 B 0.7036207 -1.12 0.2645

Site HMO-D 0.00000000 B . . .

MatADHD 4.94150945 1.6199467 3.05 0.0023

MatLangDel -6.86290855 2.3859323 -2.88 0.0041

DayCareCentrImpVal1 -0.46890298 0.1655336 -2.83 0.0047

PreNatFish_1 1.18039916 0.6615825 1.78 0.0747

EngOnly -0.58655539 0.3704873 -1.58 0.1137

PreNatFillings_1 -0.30474431 0.2197959 -1.39 0.1659

YoungerSibs -0.48563812 0.3809635 -1.27 0.2027

PctPoverty1_2 -0.01122797 0.0102224 -1.10 0.2723

OlderSibs -0.36410821 0.3828662 -0.95 0.3418

PreNatAlcohol_1 -0.33686796 0.4593616 -0.73 0.4635

cMedicalHist_1 0.58451872 1.1046244 0.53 0.5968

MatAgeCat 1 -3.27060999 B 3.1179882 -1.05 0.2945

MatAgeCat 2 0.51033165 B 0.6564983 0.78 0.4371

MatAgeCat 3 0.00000000 B . . .

PreNatHomePro_1 -0.85381156 0.8782235 -0.97 0.3312

ChildAge2 -2.20742729 4.5006800 -0.49 0.6239

ChdBWT_Grp 1 0.17362942 B 0.6721086 0.26 0.7962

ChdBWT_Grp 2 -0.31056742 B 0.4634427 -0.67 0.5029

ChdBWT_Grp 3 0.00000000 B . . .

ChildAge3 0.07388690 0.1640710 0.45 0.6526

PreNatlead_1 -0.27364305 0.4715968 -0.58 0.5619
Abt Associates, Inc. Appendix B 25

Exhibit B.22. Stanford Binet: Copying

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: VP_CopyAvRS Stanford Binet Copying Raw

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 37 1490.284447 40.277958 5.13 <.0001

Error 1000 7850.633665 7.850634

Corrected Total 1037 9340.918112

R-Square Coeff Var Root MSE VP_CopyAvRS Mean

0.159544 15.39390 2.801898 18.20135

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept 82.87716803 B 65.95043357 1.26 0.2092

PreNatThimer 0.00520093 0.01073421 0.48 0.6281

Exp07mos 0.00654110 0.01520544 0.43 0.6672

ChildAge -21.31960926 21.97925656 -0.97 0.3323

sexmale -0.60267467 0.18160335 -3.32 0.0009

ChdBWT_Grp 1 -0.72769862 B 0.35871418 -2.03 0.0428

ChdBWT_Grp 2 0.12738421 B 0.25025785 0.51 0.6109

ChdBWT_Grp 3 0.00000000 B . . .

MomIQ1 1 -0.24240941 B 0.26285008 -0.92 0.3566

MomIQ1 2 -0.38940783 B 0.23212399 -1.68 0.0937

MomIQ1 3 0.00000000 B . . .

HOME_TotalIndex 0.03170209 0.05010051 0.63 0.5270

PctPoverty1 -0.39569025 0.21231724 -1.86 0.0627

MomEduc 0 -0.37303850 B 0.48384655 -0.77 0.4409

MomEduc 1 -0.11873818 B 0.28985108 -0.41 0.6821

MomEduc 2 -0.01759745 B 0.22122384 -0.08 0.9366

MomEduc 3 0.00000000 B . . .

SingleParent -0.75788789 0.23947685 -3.16 0.0016

cMedicalHist_1 -0.54989843 0.58468388 -0.94 0.3472

Site HMO-A -0.76801667 B 0.39106148 -1.96 0.0498

Site HMO-B -0.90934668 B 0.37762039 -2.41 0.0162

Site HMO-C -0.46005230 B 0.37887446 -1.21 0.2249

Site HMO-D 0.00000000 B . . .

EngOnly -0.58487334 0.19857731 -2.95 0.0033

PreNatFillings_1 0.15732904 0.11792008 1.33 0.1824

C5APGARImpVal1 -0.21244644 0.18127162 -1.17 0.2415

IronDef_1 -1.21224432 0.61421261 -1.97 0.0487

MatLangDel -1.78980053 1.27810519 -1.40 0.1617

ChildAge2 2.35417702 2.42209474 0.97 0.3313

PctPoverty1_2 0.05625488 0.02757349 2.04 0.0416

PctPoverty1_3 -0.00189083 0.00094661 -2.00 0.0460

PreNatAlcohol_1 -0.11437560 0.24912360 -0.46 0.6463

MatAgeCat 1 -0.93476346 B 1.68265022 -0.56 0.5787

MatAgeCat 2 0.33090355 B 0.34824390 0.95 0.3422

MatAgeCat 3 0.00000000 B . . .

DayCareHomeImpVal1 -0.04279840 0.06228719 -0.69 0.4922

OlderSibs -0.12944953 0.19059646 -0.68 0.4972

ComputerExpr 0 -0.68492449 B 0.90748895 -0.75 0.4506

ComputerExpr 1 -0.17394857 B 0.18215844 -0.95 0.3398

ComputerExpr 2 0.00000000 B . . .

ChildAge3 -0.08261961 0.08830166 -0.94 0.3497

PreNatNicotine_1 0.38667018 0.34648525 1.12 0.2647

PreNatTuna_1 -0.20019142 0.17124768 -1.17 0.2427

PreNatFish_1 0.32175811 0.36016896 0.89 0.3719
Abt Associates, Inc. Appendix B 26

Exhibit B.23. GDS Vigilance Task: Correct Responses

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: IP_GDSCorAvRS GDS Vigilance CorrectResp Raw

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 45 5205.42025 115.67601 5.18 <.0001

Error 996 22239.90413 22.32922

Corrected Total 1041 27445.32438

R-Square Coeff Var Root MSE IP_GDSCorAvRS Mean

0.189665 11.67729 4.725381 40.46641

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept -193.0499988 B 111.8535913 -1.73 0.0847

PreNatThimer -0.0131828 0.0182221 -0.72 0.4696

Exp07mos 0.0323190 0.0257147 1.26 0.2091

ChildAge 70.3270306 37.2860565 1.89 0.0596

sexmale -0.3451136 0.3069123 -1.12 0.2611

ComputerExpr 0 -2.1858608 B 1.5402939 -1.42 0.1562

ComputerExpr 1 -0.6832689 B 0.3095103 -2.21 0.0275

ComputerExpr 2 0.0000000 B . . .

MomIQ1 1 -0.2369439 B 0.4492432 -0.53 0.5980

MomIQ1 2 0.0524706 B 0.3984887 0.13 0.8953

MomIQ1 3 0.0000000 B . . .

HOME_TotalIndex -0.0580323 0.0854334 -0.68 0.4971

PctPoverty1 0.4576481 0.1588401 2.88 0.0040

MomEduc 0 -0.5801615 B 0.8135693 -0.71 0.4759

MomEduc 1 -0.5665076 B 0.4949482 -1.14 0.2527

MomEduc 2 -0.4762019 B 0.3736492 -1.27 0.2028

MomEduc 3 0.0000000 B . . .

SingleParent -0.2763103 0.4070033 -0.68 0.4974

Site HMO-A -0.2874862 B 0.6650898 -0.43 0.6657

Site HMO-B -0.8096703 B 0.6383504 -1.27 0.2050

Site HMO-C -0.6402281 B 0.6462635 -0.99 0.3221

Site HMO-D 0.0000000 B . . .

cMedicalHist_1 -1.0398047 1.0102155 -1.03 0.3036

MatAgeCat 1 -1.5823726 B 2.8430506 -0.56 0.5779

MatAgeCat 2 0.5074140 B 0.5889643 0.86 0.3892

MatAgeCat 3 0.0000000 B . . .

DayCareCentrImpVal1 0.0052555 0.1520532 0.03 0.9724

DayCareHomeImpVal1 -0.1570484 0.1063933 -1.48 0.1402

BFMthsCat 0 -1.5959282 B 0.4366763 -3.65 0.0003

BFMthsCat 1 -1.0153913 B 0.3587098 -2.83 0.0047

BFMthsCat 2 0.0000000 B . . .

PreNatNicotine_1 0.5051334 0.5859067 0.86 0.3888

PreNatAlcohol_1 -0.3419779 0.4325177 -0.79 0.4293

PreNatTuna_1 -0.4415998 0.2860344 -1.54 0.1229

PreNatOrgMerc_1 0.3853381 0.3287319 1.17 0.2414

PreNatHomePro_1 1.4078674 0.7973036 1.77 0.0777

PreNatlead_1 -0.4279086 0.4312549 -0.99 0.3213

OlderSibs -0.0564985 0.3245711 -0.17 0.8618

PreNatIllDrug 0.2803462 1.5309607 0.18 0.8547

C5APGARImpVal1 0.5823583 0.3061123 1.90 0.0574

IronDef_1 -1.0286933 1.0393204 -0.99 0.3225

ADHDstimulant 3.2036483 3.5363845 0.91 0.3652

ChdPICA_1 -0.4077771 0.7561937 -0.54 0.5898

MatLangDel -2.6021805 2.3702012 -1.10 0.2725

MatSpeechDel -3.5708188 1.6722917 -2.14 0.0330

MatSTUTTER -0.5399590 1.4699705 -0.37 0.7135

ChildAge2 -7.2567110 4.1096985 -1.77 0.0777

ChildAge3 0.2525328 0.1498567 1.69 0.0923

PctPoverty1_2 -0.0284391 0.0091563 -3.11 0.0020

ChdBWT_Grp 1 0.5026427 B 0.6088836 0.83 0.4093

ChdBWT_Grp 2 0.1647625 B 0.4217239 0.39 0.6961

ChdBWT_Grp 3 0.0000000 B . . .

PreNatFillings_1 0.0753530 0.1997307 0.38 0.7061
Abt Associates, Inc. Appendix B 27

Exhibit B.24. GDS Vigilance Task: Errors (lower=better)

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: IP_GDSErrAvRS GDS Vigilance Comm.Errors Raw

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 42 35091.0864 835.5021 5.59 <.0001

Error 999 149446.7178 149.5963

Corrected Total 1041 184537.8042

R-Square Coeff Var Root MSE IP_GDSErrAvRS Mean

0.190157 161.9809 12.23096 7.550864

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept -69.84671993 B 288.8599219 -0.24 0.8090

PreNatThimer 0.03256214 0.0470678 0.69 0.4892

Exp07mos -0.02193041 0.0666121 -0.33 0.7421

ChildAge 35.60009677 96.2791010 0.37 0.7116

sexmale 3.74324583 0.7901680 4.74 <.0001

ComputerExpr 0 6.49654113 B 3.9836405 1.63 0.1032

ComputerExpr 1 0.42602465 B 0.7984031 0.53 0.5937

ComputerExpr 2 0.00000000 B . . .

MomIQ1 1 1.85638195 B 1.1521650 1.61 0.1074

MomIQ1 2 -0.19908500 B 1.0298090 -0.19 0.8467

MomIQ1 3 0.00000000 B . . .

HOME_TotalIndex -0.38931319 0.2204440 -1.77 0.0777

PctPoverty1 -0.77165795 0.9391604 -0.82 0.4115

MomEduc 0 -0.52445641 B 2.1237359 -0.25 0.8050

MomEduc 1 -0.99201893 B 1.2738857 -0.78 0.4363

MomEduc 2 -0.26735531 B 0.9659786 -0.28 0.7820

MomEduc 3 0.00000000 B . . .

SingleParent 1.32270229 1.0773614 1.23 0.2198

cMedicalHist_1 3.16803110 2.6159180 1.21 0.2262

Site HMO-A -3.09280387 B 1.7188078 -1.80 0.0723

Site HMO-B -1.39151810 B 1.6528885 -0.84 0.4001

Site HMO-C -2.89547479 B 1.6723731 -1.73 0.0837

Site HMO-D 0.00000000 B . . .

MatLangDel 35.19862909 6.1859874 5.69 <.0001

MatSpeechDel 17.62398956 4.3283433 4.07 <.0001

BFMthsCat 0 3.95021656 B 1.1199991 3.53 0.0004

BFMthsCat 1 1.51483791 B 0.9212774 1.64 0.1004

BFMthsCat 2 0.00000000 B . . .

PreNatNicotine_1 3.69182488 1.5022130 2.46 0.0142

YoungerSibs -1.90595281 0.8804148 -2.16 0.0306

PreNatTuna_1 1.52516336 0.7369693 2.07 0.0388

ChdPICA_1 -3.44019362 1.9458972 -1.77 0.0774

PreNatOrgMerc_1 -1.57233580 0.8522157 -1.84 0.0653

MatSTUTTER 6.61277151 3.8147273 1.73 0.0833

IronDef_1 4.81299260 2.6902164 1.79 0.0739

ADHDstimulant -13.00372806 9.1254177 -1.43 0.1545

MatADHD 5.29588885 3.6514720 1.45 0.1473

OlderSibs -1.26038647 0.9039479 -1.39 0.1635

PreNatAlcohol_1 1.26125448 1.0858820 1.16 0.2457

C5APGARImpVal1 -0.57855219 0.7903003 -0.73 0.4643

DayCareHomeImpVal1 0.19147691 0.2744536 0.70 0.4855

PctPoverty1_2 0.08281561 0.1210817 0.68 0.4942

ChildAge3 0.18048764 0.3868661 0.47 0.6409

PctPoverty1_3 -0.00221807 0.0041462 -0.53 0.5928

ChildAge2 -4.51587071 10.6106694 -0.43 0.6705

ChdBWT_Grp 1 0.01101243 B 1.5732597 0.01 0.9944

ChdBWT_Grp 2 0.79521855 B 1.0917856 0.73 0.4666

ChdBWT_Grp 3 0.00000000 B . . .

DayCareCentrImpVal1 -0.05522066 0.3925417 -0.14 0.8882
Abt Associates, Inc. Appendix B 28

Exhibit B.25. WISC III: Digit Span, Forward Recall

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: VM_DigitFAvRS WISC III Digit Forward Raw

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 37 567.966805 15.350454 4.96 <.0001

Error 1007 3115.702094 3.094044

Corrected Total 1044 3683.668900

R-Square Coeff Var Root MSE VM_DigitFAvRS Mean

0.154185 21.83328 1.758989 8.056459

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept 59.88568365 B 41.28334237 1.45 0.1472

PreNatThimer 0.00014418 0.00675772 0.02 0.9830

Exp07mos -0.00217751 0.00954264 -0.23 0.8195

ChildAge -19.41922476 13.75927185 -1.41 0.1584

sexmale -0.16067651 0.11357035 -1.41 0.1574

ChdBWT_Grp 1 0.14317543 B 0.22185619 0.65 0.5188

ChdBWT_Grp 2 0.15627507 B 0.15618369 1.00 0.3173

ChdBWT_Grp 3 0.00000000 B . . .

MomIQ1 1 -0.49365944 B 0.16524158 -2.99 0.0029

MomIQ1 2 -0.23373974 B 0.14721096 -1.59 0.1126

MomIQ1 3 0.00000000 B . . .

HOME_TotalIndex 0.03266155 0.03153433 1.04 0.3006

PctPoverty1 -0.11425308 0.13250101 -0.86 0.3887

MomEduc 0 0.07445869 B 0.30386167 0.25 0.8065

MomEduc 1 -0.28680885 B 0.18135268 -1.58 0.1141

MomEduc 2 -0.21502949 B 0.13817408 -1.56 0.1200

MomEduc 3 0.00000000 B . . .

SingleParent 0.16601474 0.14898977 1.11 0.2654

Site HMO-A -0.27041614 B 0.24285698 -1.11 0.2658

Site HMO-B -0.42968411 B 0.23272775 -1.85 0.0651

Site HMO-C 0.04774806 B 0.23569833 0.20 0.8395

Site HMO-D 0.00000000 B . . .

BFMthsCat 0 -0.22164707 B 0.16059631 -1.38 0.1678

BFMthsCat 1 -0.13656611 B 0.13160313 -1.04 0.2997

BFMthsCat 2 0.00000000 B . . .

PreNatNicotine_1 -0.30388250 0.21645520 -1.40 0.1607

PreNatAlcohol_1 -0.18227735 0.15618586 -1.17 0.2435

PreNatFish_1 -0.26814573 0.22446288 -1.19 0.2325

PreNatlead_1 0.25946517 0.15951853 1.63 0.1041

C5APGARImpVal1 0.38016347 0.11308113 3.36 0.0008

ADHDstimulant -1.83994286 1.28952243 -1.43 0.1539

MatLangDel -1.45095737 0.80824749 -1.80 0.0729

MatSTUTTER 1.09627494 0.53573710 2.05 0.0410

ChildAge2 2.22267614 1.51613207 1.47 0.1430

ChildAge3 -0.08232090 0.05527108 -1.49 0.1367

PctPoverty1_2 0.02569956 0.01725021 1.49 0.1366

PctPoverty1_3 -0.00096505 0.00059297 -1.63 0.1039

PreNatHomePro_1 -0.30046867 0.29384215 -1.02 0.3068

MatAgeCat 1 -0.88004626 B 1.05511072 -0.83 0.4044

MatAgeCat 2 -0.26131766 B 0.21876168 -1.19 0.2326

MatAgeCat 3 0.00000000 B . . .

ComputerExpr 0 0.33610982 B 0.56783345 0.59 0.5540

ComputerExpr 1 -0.08236410 B 0.11438663 -0.72 0.4717

ComputerExpr 2 0.00000000 B . . .

OlderSibs 0.05177436 0.11916333 0.43 0.6640
Abt Associates, Inc. Appendix B 29

Exhibit B.26. WISC III: Digit Span, Backward Recall

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: VM_DigitBAvRS WISC III Digit Backward Raw

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 23 343.397070 14.930307 6.22 <.0001

Error 1022 2453.242509 2.400433

Corrected Total 1045 2796.639579

R-Square Coeff Var Root MSE VM_DigitBAvRS Mean

0.122789 34.21158 1.549333 4.528681

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept 0.659445479 B 0.64045013 1.03 0.3034

PreNatThimer -0.013014344 0.00586881 -2.22 0.0268

Exp07mos 0.017996008 0.00819061 2.20 0.0282

ChildAge 0.404266683 0.04581599 8.82 <.0001

sexmale -0.009865011 0.09873044 -0.10 0.9204

ChdBWT_Grp 1 -0.255193601 B 0.19581930 -1.30 0.1928

ChdBWT_Grp 2 0.036297214 B 0.13698875 0.26 0.7911

ChdBWT_Grp 3 0.000000000 B . . .

MomIQ1 1 -0.399025949 B 0.14318885 -2.79 0.0054

MomIQ1 2 -0.209639725 B 0.12857734 -1.63 0.1033

MomIQ1 3 0.000000000 B . . .

HOME_TotalIndex -0.000398698 0.02730753 -0.01 0.9884

PctPoverty1 0.006092171 0.02049944 0.30 0.7664

MomEduc 0 0.038635355 B 0.25834195 0.15 0.8811

MomEduc 1 -0.090385479 B 0.15759057 -0.57 0.5664

MomEduc 2 -0.061309312 B 0.12051111 -0.51 0.6110

MomEduc 3 0.000000000 B . . .

SingleParent -0.112260314 0.12824234 -0.88 0.3816

cMedicalHist_1 -0.358146668 0.32149481 -1.11 0.2655

Site HMO-A 0.290454240 B 0.21180567 1.37 0.1706

Site HMO-B 0.284691178 B 0.20223715 1.41 0.1595

Site HMO-C 0.083715945 B 0.20522833 0.41 0.6834

Site HMO-D 0.000000000 B . . .

PreNatIllDrug -1.081323496 0.47690653 -2.27 0.0236

MatADHD -1.238314126 0.45483482 -2.72 0.0066

BFMthsCat 0 -0.314463633 B 0.13829789 -2.27 0.0232

BFMthsCat 1 -0.239451022 B 0.11415384 -2.10 0.0362

BFMthsCat 2 0.000000000 B . . .

ADHDstimulant -1.541106835 1.10136805 -1.40 0.1620
Abt Associates, Inc. Appendix B 30

Exhibit B.27. WISC III: Digit Span, Combined

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: VM_DigitCAvRS WISC III Digit Combine Raw

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 30 1568.484456 52.282815 7.09 <.0001

Error 1014 7473.770089 7.370582

Corrected Total 1044 9042.254545

R-Square Coeff Var Root MSE VM_DigitCAvRS Mean

0.173462 21.57782 2.714882 12.58182

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept 1.748816109 B 1.96672717 0.89 0.3741

PreNatThimer -0.012051289 0.01032871 -1.17 0.2436

Exp07mos 0.017029071 0.01455013 1.17 0.2421

ChildAge 0.794442236 0.08059301 9.86 <.0001

sexmale -0.140797931 0.17387135 -0.81 0.4183

ChdBWT_Grp 1 -0.094891523 B 0.34506523 -0.27 0.7834

ChdBWT_Grp 2 0.241691921 B 0.24109235 1.00 0.3163

ChdBWT_Grp 3 0.000000000 B . . .

MomIQ1 1 -0.831254907 B 0.25246108 -3.29 0.0010

MomIQ1 2 -0.418184540 B 0.22598027 -1.85 0.0645

MomIQ1 3 0.000000000 B . . .

HOME_TotalIndex 0.032063278 0.04833604 0.66 0.5073

PctPoverty1 -0.028438738 0.20402592 -0.14 0.8892

MomEduc 0 0.169983633 B 0.46395941 0.37 0.7142

MomEduc 1 -0.431582004 B 0.27934742 -1.54 0.1227

MomEduc 2 -0.270483368 B 0.21161017 -1.28 0.2015

MomEduc 3 0.000000000 B . . .

SingleParent 0.047701312 0.22978216 0.21 0.8356

Site HMO-A 0.014016305 B 0.37430875 0.04 0.9701

Site HMO-B -0.086411963 B 0.35810667 -0.24 0.8094

Site HMO-C 0.193419861 B 0.36298402 0.53 0.5942

Site HMO-D 0.000000000 B . . .

cMedicalHist_1 -0.564487301 0.56436602 -1.00 0.3174

BFMthsCat 0 -0.631805697 B 0.24346313 -2.60 0.0096

BFMthsCat 1 -0.423445870 B 0.20089189 -2.11 0.0353

BFMthsCat 2 0.000000000 B . . .

PreNatFish_1 -0.537033068 0.34794842 -1.54 0.1230

PreNatlead_1 0.403739914 0.24369535 1.66 0.0979

PreNatIllDrug -1.425721456 0.83626063 -1.70 0.0885

C5APGARImpVal1 0.361424603 0.17366368 2.08 0.0377

ADHDstimulant -2.712466528 1.93908000 -1.40 0.1622

MatLangDel -1.762324081 1.24326426 -1.42 0.1566

MatADHD -1.550546946 0.80403638 -1.93 0.0541

OlderSibs 0.190611074 0.18187743 1.05 0.2949

PctPoverty1_2 0.020179144 0.02657606 0.76 0.4479

PctPoverty1_3 -0.000932844 0.00091387 -1.02 0.3076
Abt Associates, Inc. Appendix B 31

Exhibit B.28. BRIEF Parent Rating: Metacognition (lower = better)

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: AD_PmetaRS Brief Parent Metacognition Raw

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 36 45309.1542 1258.5876 4.28 <.0001

Error 1005 295824.3285 294.3526

Corrected Total 1041 341133.4827

R-Square Coeff Var Root MSE AD_PmetaRS Mean

0.132819 23.09638 17.15671 74.28311

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept 186.4553850 B 403.3638016 0.46 0.6440

PreNatThimer 0.0214600 0.0656028 0.33 0.7436

Exp07mos -0.0516885 0.0917744 -0.56 0.5734

ChildAge -48.4404236 134.3793929 -0.36 0.7186

sexmale 6.5708405 1.1071096 5.94 <.0001

ChdBWT_Grp 1 -1.1240647 B 2.1907110 -0.51 0.6080

ChdBWT_Grp 2 -1.5466865 B 1.5297063 -1.01 0.3122

ChdBWT_Grp 3 0.0000000 B . . .

ComputerExpr 0 -1.3445982 B 5.5725892 -0.24 0.8094

ComputerExpr 1 2.5164727 B 1.1195146 2.25 0.0248

ComputerExpr 2 0.0000000 B . . .

MomIQ1 1 -3.5371576 B 1.5891095 -2.23 0.0262

MomIQ1 2 -0.5929974 B 1.4187657 -0.42 0.6761

MomIQ1 3 0.0000000 B . . .

HOME_TotalIndex -0.8668476 0.3058365 -2.83 0.0047

PctPoverty1 -0.0492650 0.2295320 -0.21 0.8301

MomEduc 0 7.2865379 B 2.9079738 2.51 0.0124

MomEduc 1 2.3397118 B 1.7642811 1.33 0.1851

MomEduc 2 2.0228309 B 1.3496385 1.50 0.1342

MomEduc 3 0.0000000 B . . .

SingleParent 1.6220139 1.4542991 1.12 0.2650

cMedicalHist_1 6.0401238 3.5937032 1.68 0.0931

Site HMO-A 2.4849043 B 2.3499008 1.06 0.2906

Site HMO-B 4.0770263 B 2.2666282 1.80 0.0724

Site HMO-C 4.2870196 B 2.2746844 1.88 0.0598

Site HMO-D 0.0000000 B . . .

DayCareCentrImpVal1 1.0296884 0.5474222 1.88 0.0603

DayCareHomeImpVal1 0.9730097 0.3820257 2.55 0.0110

EngOnly 1.3886911 1.2095018 1.15 0.2512

PreNatNicotine_1 4.8307495 2.0972350 2.30 0.0215

PreNatAlcohol_1 3.2242403 1.5174181 2.12 0.0338

PreNatTuna_1 2.5559621 1.0295237 2.48 0.0132

PreNatOrgMerc_1 -1.8199599 1.1891754 -1.53 0.1262

ADHDstimulant 26.3909073 12.2707102 2.15 0.0317

ChdPICA_1 5.9955236 2.7307866 2.20 0.0284

MatLangDel 12.4608941 7.8714806 1.58 0.1137

MatADHD 9.7526213 5.1118925 1.91 0.0567

PreNatHomePro_1 2.6670818 2.8643516 0.93 0.3520

C5APGARImpVal1 1.0704541 1.1025570 0.97 0.3318

PreNatlead_1 1.0208712 1.5533163 0.66 0.5112

ChildAge2 6.1688442 14.8107303 0.42 0.6771

ChildAge3 -0.2547713 0.5400249 -0.47 0.6372
Abt Associates, Inc. Appendix B 32

Exhibit B.29. BRIEF Teacher Rating: Metacognition (lower = better)

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: AD_TmetaRS Brief Teacher Metacognition Raw

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 38 69079.9870 1817.8944 4.14 <.0001

Error 743 326429.1230 439.3393

Corrected Total 781 395509.1100

R-Square Coeff Var Root MSE AD_TmetaRS Mean

0.174661 31.14038 20.96042 67.30946

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept 13.49070624 B 62.05574615 0.22 0.8280

PreNatThimer 0.02649494 0.08805253 0.30 0.7636

Exp07mos -0.14696388 0.13256998 -1.11 0.2680

ChildAge 11.29896879 12.92536727 0.87 0.3823

sexmale 12.19193682 1.58079374 7.71 <.0001

ChdBWT_Grp 1 1.14082429 B 3.19076119 0.36 0.7208

ChdBWT_Grp 2 -1.19966812 B 2.21486355 -0.54 0.5882

ChdBWT_Grp 3 0.00000000 B . . .

MomIQ1 1 2.29281342 B 2.37110591 0.97 0.3339

MomIQ1 2 0.71677856 B 2.04798859 0.35 0.7264

MomIQ1 3 0.00000000 B . . .

HOME_TotalIndex -1.31819975 0.44832206 -2.94 0.0034

PctPoverty1 -1.22830631 0.80082237 -1.53 0.1255

MomEduc 0 4.99935209 B 4.26313018 1.17 0.2413

MomEduc 1 -0.52328509 B 2.57477035 -0.20 0.8390

MomEduc 2 1.03687357 B 1.95241118 0.53 0.5955

MomEduc 3 0.00000000 B . . .

SingleParent -0.41014648 2.17723516 -0.19 0.8506

cMedicalHist_1 3.65179270 5.34233032 0.68 0.4945

Site HMO-A -1.93173210 B 3.32661958 -0.58 0.5616

Site HMO-B 2.07672622 B 3.20893083 0.65 0.5177

Site HMO-C -0.69561996 B 3.17826754 -0.22 0.8268

Site HMO-D 0.00000000 B . . .

DayCareCentrImpVal1 1.93501610 0.78519077 2.46 0.0139

EngOnly 2.75323707 1.76857149 1.56 0.1200

BFMthsCat 0 4.21196358 B 2.30224783 1.83 0.0677

BFMthsCat 1 2.41636605 B 1.80812783 1.34 0.1818

BFMthsCat 2 0.00000000 B . . .

PreNatAlcohol_1 4.53356375 2.37288011 1.91 0.0564

PreNatTuna_1 2.25551446 1.46559608 1.54 0.1242

PreNatOrgMerc_1 -2.53987537 1.68675950 -1.51 0.1326

PreNatFillings_1 1.47867035 1.02811367 1.44 0.1508

ADHDstimulant 33.60699103 21.40072465 1.57 0.1168

MatADHD 10.91323185 8.20005947 1.33 0.1836

PctPoverty1_2 0.06813775 0.04476183 1.52 0.1284

PreNatNicotine_1 3.38494338 3.05348046 1.11 0.2680

DayCareHomeImpVal1 0.55371029 0.52050102 1.06 0.2878

ChildAge2 -0.63097304 0.70358866 -0.90 0.3701

MatSTUTTER -6.65244178 6.85852217 -0.97 0.3324

C5APGARImpVal1 1.46006445 1.47993143 0.99 0.3242

PreNatHomePro_1 3.32054342 4.01942354 0.83 0.4090

PreNatlead_1 -1.36427818 2.15490233 -0.63 0.5269

MatAgeCat 1 -2.29303179 B 12.68057630 -0.18 0.8566

MatAgeCat 2 -3.55539973 B 2.83288153 -1.26 0.2099

MatAgeCat 3 0.00000000 B . . .
Abt Associates, Inc. Appendix B 33

Exhibit B.30. CRS-R: Parent Rating: Hyperactive/Impulsive (lower = better)

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: AD_PhyperRS Conners Parent Hypr/Impulsive Raw

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 31 3327.25585 107.33083 4.57 <.0001

Error 1009 23678.61351 23.46741

Corrected Total 1040 27005.86936

R-Square Coeff Var Root MSE AD_PhyperRS Mean

0.123205 89.35035 4.844317 5.421710

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept 6.78806853 B 2.15143705 3.16 0.0017

PreNatThimer 0.00652025 0.01851165 0.35 0.7247

Exp07mos 0.01878567 0.02595401 0.72 0.4694

ChildAge -0.36383385 0.14510805 -2.51 0.0123

sexmale 1.34181594 0.31113307 4.31 <.0001

ChdBWT_Grp 1 0.14975727 B 0.61017763 0.25 0.8062

ChdBWT_Grp 2 -0.38849389 B 0.43037886 -0.90 0.3669

ChdBWT_Grp 3 0.00000000 B . . .

MomIQ1 1 -0.59120616 B 0.45194528 -1.31 0.1911

MomIQ1 2 -0.59989294 B 0.40680406 -1.47 0.1406

MomIQ1 3 0.00000000 B . . .

HOME_TotalIndex -0.09212839 0.08615040 -1.07 0.2851

PctPoverty1 -0.25968214 0.16075072 -1.62 0.1065

MomEduc 0 -0.03167412 B 0.82481966 -0.04 0.9694

MomEduc 1 0.16063294 B 0.50090528 0.32 0.7485

MomEduc 2 0.00590529 B 0.38064274 0.02 0.9876

MomEduc 3 0.00000000 B . . .

SingleParent 0.83050434 0.41222263 2.01 0.0442

Site HMO-A 0.62910049 B 0.66622712 0.94 0.3453

Site HMO-B 1.33078530 B 0.63515919 2.10 0.0364

Site HMO-C 0.76289012 B 0.64727682 1.18 0.2388

Site HMO-D 0.00000000 B . . .

OlderSibs 0.89352872 0.32892199 2.72 0.0067

DayCareCentrImpVal1 0.47342448 0.15479216 3.06 0.0023

DayCareHomeImpVal1 0.20136288 0.10773185 1.87 0.0619

PreNatNicotine_1 1.93888109 0.59291988 3.27 0.0011

PreNatHomePro_1 1.11036562 0.80488740 1.38 0.1680

ADHDstimulant 12.96340985 3.46235093 3.74 0.0002

ChdPICA_1 1.21912012 0.76685340 1.59 0.1122

MatADHD 6.82306455 1.42654374 4.78 <.0001

PctPoverty1_2 0.01735092 0.00930040 1.87 0.0624

PreNatAlcohol_1 0.49417255 0.42858186 1.15 0.2492

BFMthsCat 0 0.20671443 B 0.44086723 0.47 0.6393

BFMthsCat 1 0.49959576 B 0.36360809 1.37 0.1697

BFMthsCat 2 0.00000000 B . . .

MatAgeCat 1 -1.62356656 B 2.90583350 -0.56 0.5765

MatAgeCat 2 0.48061233 B 0.60215344 0.80 0.4250

MatAgeCat 3 0.00000000 B . . .
Abt Associates, Inc. Appendix B 34

Exhibit B.31. CRS-R: Teacher Rating: Hyperactive/Impulsive (lower = better)

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: AD_ThyperRS Conners Teacher Hypr/Impulsive Raw

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 28 3961.72719 141.49026 4.88 <.0001

Error 748 21708.66663 29.02228

Corrected Total 776 25670.39382

R-Square Coeff Var Root MSE AD_ThyperRS Mean

0.154331 136.6595 5.387233 3.942085

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept 2.27787467 B 4.34675115 0.52 0.6004

PreNatThimer 0.02292990 0.02215057 1.04 0.3009

Exp07mos -0.04791747 0.03379566 -1.42 0.1566

ChildAge -0.17130697 0.18614827 -0.92 0.3577

sexmale 2.74525836 0.40452993 6.79 <.0001

ChdBWT_Grp 1 -0.10157492 B 0.81577150 -0.12 0.9009

ChdBWT_Grp 2 -0.16535476 B 0.57005461 -0.29 0.7718

ChdBWT_Grp 3 0.00000000 B . . .

MomIQ1 1 0.09696336 B 0.59874219 0.16 0.8714

MomIQ1 2 -0.61354060 B 0.51995158 -1.18 0.2384

MomIQ1 3 0.00000000 B . . .

HOME_TotalIndex -0.06950733 0.11473025 -0.61 0.5448

PctPoverty1 -0.56066852 0.20535247 -2.73 0.0065

MomEduc 0 -1.09432227 B 1.08607733 -1.01 0.3140

MomEduc 1 -0.14284316 B 0.66011473 -0.22 0.8287

MomEduc 2 -0.06766299 B 0.49724767 -0.14 0.8918

MomEduc 3 0.00000000 B . . .

SingleParent 1.64890922 0.55322063 2.98 0.0030

cMedicalHist_1 0.88590399 1.37184049 0.65 0.5186

Site HMO-A -0.64737011 B 0.84310015 -0.77 0.4428

Site HMO-B 0.29587244 B 0.81362683 0.36 0.7162

Site HMO-C -0.12026570 B 0.80429416 -0.15 0.8812

Site HMO-D 0.00000000 B . . .

DayCareCentrImpVal1 0.30560222 0.20038203 1.53 0.1277

EngOnly 0.82944355 0.45095855 1.84 0.0663

BFMthsCat 0 1.04632267 B 0.58509131 1.79 0.0741

BFMthsCat 1 1.14051082 B 0.45990198 2.48 0.0134

BFMthsCat 2 0.00000000 B . . .

PreNatTuna_1 0.50219637 0.37512653 1.34 0.1811

PreNatOrgMerc_1 -0.89396467 0.43108436 -2.07 0.0384

PreNatIllDrug 2.37717245 2.08481294 1.14 0.2546

C5APGARImpVal1 0.41850512 0.37721610 1.11 0.2676

ADHDstimulant 19.53729622 5.48354269 3.56 0.0004

PctPoverty1_2 0.03167874 0.01147692 2.76 0.0059
Abt Associates, Inc. Appendix B 35

Exhibit B.32. CRS-R: Parent Rating: Inattentive (lower = better)

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: AD_PinattentRS Conners Parent Inattent Raw

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 33 4806.73707 145.65870 4.61 <.0001

Error 1007 31839.35131 31.61803

Corrected Total 1040 36646.08838

R-Square Coeff Var Root MSE AD_PinattentRS Mean

0.131166 89.27152 5.622991 6.298751

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept -9.00289995 B 13.93995243 -0.65 0.5185

PreNatThimer 0.01108811 0.02150918 0.52 0.6063

Exp07mos -0.02358467 0.03005415 -0.78 0.4328

ChildAge 3.95901845 3.03684859 1.30 0.1926

sexmale 2.32540287 0.36245247 6.42 <.0001

ChdBWT_Grp 1 0.25734703 B 0.71672068 0.36 0.7196

ChdBWT_Grp 2 -0.34394188 B 0.50279690 -0.68 0.4941

ChdBWT_Grp 3 0.00000000 B . . .

ComputerExpr 0 0.08637021 B 1.82044377 0.05 0.9622

ComputerExpr 1 0.74917938 B 0.36489154 2.05 0.0403

ComputerExpr 2 0.00000000 B . . .

MomIQ1 1 -0.87839529 B 0.51771351 -1.70 0.0901

MomIQ1 2 -0.54991805 B 0.46327417 -1.19 0.2355

MomIQ1 3 0.00000000 B . . .

HOME_TotalIndex -0.34762176 0.10023007 -3.47 0.0005

PctPoverty1 -0.35049919 0.18770856 -1.87 0.0622

MomEduc 0 -0.02624435 B 0.95856280 -0.03 0.9782

MomEduc 1 -0.51262795 B 0.58100302 -0.88 0.3778

MomEduc 2 0.00081419 B 0.44205445 0.00 0.9985

MomEduc 3 0.00000000 B . . .

SingleParent 0.36462581 0.48040453 0.76 0.4480

cMedicalHist_1 0.79156076 1.17272630 0.67 0.4998

Site HMO-A -0.05863280 B 0.76716908 -0.08 0.9391

Site HMO-B 0.68324610 B 0.73702758 0.93 0.3541

Site HMO-C 0.49138085 B 0.74594648 0.66 0.5102

Site HMO-D 0.00000000 B . . .

ADHDstimulant 14.30399239 4.02305453 3.56 0.0004

DayCareHomeImpVal1 0.35133391 0.12440679 2.82 0.0048

MatADHD 4.08049682 1.67267153 2.44 0.0149

PctPoverty1_2 0.02203243 0.01083541 2.03 0.0423

PreNatTuna_1 0.66029327 0.34089163 1.94 0.0530

PreNatAlcohol_1 1.14560088 0.49690140 2.31 0.0213

PreNatNicotine_1 1.25961757 0.68701073 1.83 0.0670

ChdPICA_1 1.56943018 0.88992674 1.76 0.0781

PreNatFish_1 -1.27035100 0.72373432 -1.76 0.0795

MatLangDel 3.72137831 2.57658430 1.44 0.1490

DayCareCentrImpVal1 0.26531921 0.17904051 1.48 0.1387

EngOnly 0.52597363 0.39668253 1.33 0.1852

ChildAge2 -0.21575731 0.16550795 -1.30 0.1927
Abt Associates, Inc. Appendix B 36

Exhibit B.33. CRS-R: Teacher Rating: Inattentive (lower = better)

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: AD_TinattentRS Conners Teacher Inattent Raw

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 31 6362.78320 205.25107 4.33 <.0001

Error 745 35293.33263 47.37360

Corrected Total 776 41656.11583

R-Square Coeff Var Root MSE AD_TinattentRS Mean

0.152745 102.9843 6.882848 6.683398

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept 8.24496718 B 3.45911048 2.38 0.0174

PreNatThimer 0.00217719 0.02861709 0.08 0.9394

Exp07mos -0.03414964 0.04346174 -0.79 0.4323

ChildAge -0.11356431 0.23873847 -0.48 0.6344

sexmale 3.92078520 0.51976051 7.54 <.0001

ChdBWT_Grp 1 0.48525750 B 1.03610092 0.47 0.6397

ChdBWT_Grp 2 -0.35586750 B 0.72150421 -0.49 0.6220

ChdBWT_Grp 3 0.00000000 B . . .

ComputerExpr 0 -2.56339680 B 2.67050960 -0.96 0.3374

ComputerExpr 1 0.57455306 B 0.51700174 1.11 0.2668

ComputerExpr 2 0.00000000 B . . .

MomIQ1 1 0.94123247 B 0.76344491 1.23 0.2180

MomIQ1 2 -0.03132105 B 0.67104479 -0.05 0.9628

MomIQ1 3 0.00000000 B . . .

HOME_TotalIndex -0.40939501 0.14572602 -2.81 0.0051

PctPoverty1 -0.05010674 0.10160280 -0.49 0.6220

MomEduc 0 1.94677921 B 1.36811500 1.42 0.1552

MomEduc 1 -0.55602775 B 0.83496024 -0.67 0.5057

MomEduc 2 0.19656572 B 0.63688711 0.31 0.7577

MomEduc 3 0.00000000 B . . .

SingleParent 0.21536389 0.69235596 0.31 0.7558

Site HMO-A -0.17011284 B 1.08519867 -0.16 0.8755

Site HMO-B 0.97149572 B 1.04492344 0.93 0.3528

Site HMO-C -0.06762439 B 1.03777326 -0.07 0.9481

Site HMO-D 0.00000000 B . . .

DayCareHomeImpVal1 0.09868783 0.17019797 0.58 0.5622

PreNatFillings_1 0.67207176 0.33645469 2.00 0.0461

PreNatTuna_1 0.75755764 0.48005958 1.58 0.1150

PreNatNicotine_1 1.69444743 1.00394178 1.69 0.0919

ADHDstimulant 11.68771604 7.00981809 1.67 0.0959

BFMthsCat 0 1.44854103 B 0.75511885 1.92 0.0555

BFMthsCat 1 1.10001956 B 0.58434756 1.88 0.0602

BFMthsCat 2 0.00000000 B . . .

MatADHD 4.24532663 2.67881532 1.58 0.1134

MatLangDel 5.63611876 3.51799322 1.60 0.1096

cMedicalHist_1 0.15577494 1.73987924 0.09 0.9287

PreNatHomePro_1 1.58687348 1.31701115 1.20 0.2286

PreNatAlcohol_1 0.87109421 0.77242920 1.13 0.2598
Abt Associates, Inc. Appendix B 37

Exhibit B.34. BRIEF Parent Rating: Behavior Regulation (lower = better)

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: AD_PBehavRS Brief Parent Behave Regulation Raw

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 29 11965.2924 412.5963 3.82 <.0001

Error 1012 109204.8804 107.9100

Corrected Total 1041 121170.1727

R-Square Coeff Var Root MSE AD_PBehavRS Mean

0.098748 24.56934 10.38797 42.28023

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept 41.82212013 B 4.41675878 9.47 <.0001

PreNatThimer -0.02112931 0.03966398 -0.53 0.5944

Exp07mos 0.07650641 0.05531345 1.38 0.1669

ChildAge -0.60654802 0.30960109 -1.96 0.0504

sexmale 2.15031161 0.66586022 3.23 0.0013

ChdBWT_Grp 1 -1.36159341 B 1.32107697 -1.03 0.3029

ChdBWT_Grp 2 -1.75045798 B 0.92042492 -1.90 0.0575

ChdBWT_Grp 3 0.00000000 B . . .

MomIQ1 1 -0.85943778 B 0.94430326 -0.91 0.3630

MomIQ1 2 -0.58703509 B 0.85853579 -0.68 0.4943

MomIQ1 3 0.00000000 B . . .

HOME_TotalIndex 0.00160728 0.18427916 0.01 0.9930

PctPoverty1 -0.68529405 0.34353661 -1.99 0.0463

MomEduc 0 2.65943247 B 1.76784333 1.50 0.1328

MomEduc 1 1.28173965 B 1.06926887 1.20 0.2309

MomEduc 2 0.62062653 B 0.81200305 0.76 0.4449

MomEduc 3 0.00000000 B . . .

SingleParent 1.86446978 0.88268697 2.11 0.0349

Site HMO-A 2.03833967 B 1.41957028 1.44 0.1513

Site HMO-B 3.07497448 B 1.35731822 2.27 0.0237

Site HMO-C 2.76649848 B 1.37756386 2.01 0.0449

Site HMO-D 0.00000000 B . . .

cMedicalHist_1 2.17630220 2.16598456 1.00 0.3153

OlderSibs 1.37679806 0.70267862 1.96 0.0503

DayCareCentrImpVal1 0.87625546 0.32980262 2.66 0.0080

DayCareHomeImpVal1 0.51687329 0.23044870 2.24 0.0251

PreNatNicotine_1 2.42528419 1.26394524 1.92 0.0553

PreNatTuna_1 1.04830551 0.62198271 1.69 0.0922

PreNatHomePro_1 3.31503605 1.72373035 1.92 0.0547

ADHDstimulant 21.86285447 7.40915387 2.95 0.0032

ChdPICA_1 3.70447652 1.64461001 2.25 0.0245

MatADHD 10.43012639 3.05907892 3.41 0.0007

PctPoverty1_2 0.04562536 0.01987804 2.30 0.0219

PreNatAlcohol_1 1.24203668 0.91862079 1.35 0.1767
Abt Associates, Inc. Appendix B 38

Exhibit B.35. BRIEF Teacher Rating: Behavior Regulation (lower = better)

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: AD_TBehavRS Brief Teacher Behave Regulation Raw

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 36 17189.6481 477.4902 3.74 <.0001

Error 745 95188.2048 127.7694

Corrected Total 781 112377.8529

R-Square Coeff Var Root MSE AD_TBehavRS Mean

0.152963 29.13718 11.30351 38.79412

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept 77.15379350 B 33.33988216 2.31 0.0209

PreNatThimer 0.03548616 0.04750101 0.75 0.4553

Exp07mos -0.04461168 0.07194519 -0.62 0.5354

ChildAge -7.83055942 6.94475175 -1.13 0.2599

sexmale 4.91268991 0.84801114 5.79 <.0001

ChdBWT_Grp 1 -1.17179831 B 1.72145897 -0.68 0.4963

ChdBWT_Grp 2 -0.64553856 B 1.19249606 -0.54 0.5884

ChdBWT_Grp 3 0.00000000 B . . .

MomIQ1 1 1.10684707 B 1.26495641 0.88 0.3819

MomIQ1 2 -0.23800633 B 1.10766669 -0.21 0.8299

MomIQ1 3 0.00000000 B . . .

HOME_TotalIndex -0.26385500 0.24001693 -1.10 0.2720

PctPoverty1 -3.14798091 1.00112456 -3.14 0.0017

MomEduc 0 -2.74191790 B 2.32566958 -1.18 0.2388

MomEduc 1 -0.23472786 B 1.38841490 -0.17 0.8658

MomEduc 2 -0.29604118 B 1.05103622 -0.28 0.7783

MomEduc 3 0.00000000 B . . .

SingleParent 1.05685110 1.19722371 0.88 0.3777

Site HMO-A -1.15521142 B 1.79445122 -0.64 0.5199

Site HMO-B 0.51970246 B 1.72889993 0.30 0.7638

Site HMO-C -1.53651955 B 1.71959619 -0.89 0.3719

Site HMO-D 0.00000000 B . . .

cMedicalHist_1 4.80320069 2.86373417 1.68 0.0939

OlderSibs -1.29588922 0.97964679 -1.32 0.1863

YoungerSibs -1.60709838 0.95578526 -1.68 0.0931

DayCareCentrImpVal1 1.36403187 0.42452098 3.21 0.0014

EngOnly 1.98462528 0.94760218 2.09 0.0366

BFMthsCat 0 1.49756841 B 1.23473014 1.21 0.2256

BFMthsCat 1 1.60008498 B 0.96920549 1.65 0.0992

BFMthsCat 2 0.00000000 B . . .

PreNatAlcohol_1 1.83463316 1.28080204 1.43 0.1524

PreNatlead_1 -1.67625135 1.16551061 -1.44 0.1508

ADHDstimulant 38.97436043 11.55467774 3.37 0.0008

MatADHD 7.06307904 4.41946011 1.60 0.1104

PctPoverty1_2 0.33024335 0.12577439 2.63 0.0088

PctPoverty1_3 -0.00860295 0.00421835 -2.04 0.0418

C5APGARImpVal1 0.77506142 0.79781945 0.97 0.3316

ChildAge2 0.39596381 0.37803799 1.05 0.2952

PreNatNicotine_1 0.85654635 1.64690821 0.52 0.6032

DayCareHomeImpVal1 0.17953933 0.28122943 0.64 0.5234

MatSTUTTER -2.79089122 3.70935524 -0.75 0.4521

PreNatHomePro_1 1.13597687 2.16526234 0.52 0.6000
Abt Associates, Inc. Appendix B 39

Exhibit B.36. Motor tics (current): Assessor Rating (lower = better)

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Response Variable Tc_CAMotorYN Tics CA Motor Yes/No

Model Fit Statistics

Intercept

Intercept and

Criterion Only Covariates

AIC 629.246 626.375

SC 634.197 789.752

-2 Log L 627.246 560.375

Testing Global Null Hypothesis: BETA=0

Test Chi-Square DF Pr > ChiSq

Likelihood Ratio 66.8708 32 0.0003

Score 63.8336 32 0.0007

Wald 56.6682 32 0.0046

Standard Wald

Parameter DF Estimate Error Chi-Square Pr > ChiSq

Intercept 1 -194.1 88.2093 4.8424 0.0278

PreNatThimer 1 0.0174 0.0107 2.6443 0.1039

Exp07mos 1 0.0323 0.0220 2.1582 0.1418

ChildAge 1 64.1172 29.3441 4.7743 0.0289

sexmale 1 0.7378 0.2447 9.0909 0.0026

ChdBWT_Grp 1 1 0.3984 0.4504 0.7823 0.3764

ChdBWT_Grp 2 1 -0.0411 0.3347 0.0151 0.9021

MomIQ1 1 1 0.3597 0.3487 1.0639 0.3023

MomIQ1 2 1 0.4026 0.3004 1.7956 0.1802

HOME_TotalIndex 1 -0.00120 0.0630 0.0004 0.9848

PctPoverty1 1 0.2915 0.2784 1.0963 0.2951

MomEduc 1 0.0893 0.1604 0.3098 0.5778

SingleParent 1 -0.2547 0.3295 0.5976 0.4395

Site HMO-A 1 -0.7494 0.4872 2.3667 0.1239

Site HMO-B 1 -0.0772 0.4409 0.0307 0.8610

Site HMO-C 1 -0.2874 0.4383 0.4300 0.5120

ChildAge2 1 -7.1294 3.2260 4.8841 0.0271

ChildAge3 1 0.2616 0.1173 4.9703 0.0258

PctPoverty1_2 1 -0.0346 0.0352 0.9671 0.3254

PctPoverty1_3 1 0.00118 0.00115 1.0632 0.3025

BFMthsCat 0 1 0.3134 0.3428 0.8355 0.3607

BFMthsCat 1 1 0.6054 0.2809 4.6448 0.0311

C5APGARImpVal1 1 -0.2432 0.1890 1.6559 0.1982

cMedicalHist_1 1 0.6732 0.7013 0.9214 0.3371

ComputerExpr 1 0.6113 0.2476 6.0975 0.0135

DayCareCentrImpVal1 1 0.0918 0.1116 0.6774 0.4105

DayCareHomeImpVal1 1 0.1059 0.0737 2.0605 0.1512

IronDef 1 1.3277 0.6515 4.1530 0.0416

MatSTUTTER 1 1.1835 0.8274 2.0461 0.1526

PreNatAlcohol_1 1 -0.9482 0.5812 2.6615 0.1028

PreNatFish_1 1 -1.1366 0.6463 3.0927 0.0786

PreNatHomePro_1 1 0.2000 0.5364 0.1390 0.7093

PreNatTuna_1 1 0.3654 0.2189 2.7849 0.0952

Association of Predicted Probabilities and Observed Responses

Percent Concordant 74.0 Somers' D 0.486

Percent Discordant 25.3 Gamma 0.490

Percent Tied 0.7 Tau-a 0.079

Pairs 88443 c 0.743
Abt Associates, Inc. Appendix B 40

Exhibit B.37. Phonics tics (current): Assessor Rating (lower = better)

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Response Variable Tc_CAPhonicYN Tics CA Phonic Yes/No

Model Fit Statistics

Intercept

Intercept and

Criterion Only Covariates

AIC 546.580 540.324

SC 551.531 654.193

-2 Log L 544.580 494.324

Testing Global Null Hypothesis: BETA=0

Test Chi-Square DF Pr > ChiSq

Likelihood Ratio 50.2566 22 0.0005

Score 48.1513 22 0.0010

Wald 43.9004 22 0.0036

Standard Wald

Parameter DF Estimate Error Chi-Square Pr > ChiSq

Intercept 1 -2.1108 1.6194 1.6990 0.1924

PreNatThimer 1 -0.0106 0.0181 0.3392 0.5603

Exp07mos 1 0.0372 0.0227 2.6795 0.1016

ChildAge 1 -0.2429 0.1166 4.3395 0.0372

sexmale 1 0.7796 0.2611 8.9138 0.0028

ChdBWT_Grp 1 1 -0.0437 0.5033 0.0075 0.9309

ChdBWT_Grp 2 1 -0.0927 0.3616 0.0658 0.7976

MomIQ1 1 1 0.5677 0.3625 2.4523 0.1174

MomIQ1 2 1 0.0249 0.3433 0.0053 0.9422

HOME_TotalIndex 1 -0.0967 0.0674 2.0558 0.1516

PctPoverty1 1 0.6314 0.3118 4.1002 0.0429

MomEduc 1 0.1286 0.1700 0.5722 0.4494

SingleParent 1 0.6588 0.3019 4.7609 0.0291

Site HMO-A 1 -0.8057 0.4935 2.6653 0.1026

Site HMO-B 1 -0.3763 0.4425 0.7234 0.3950

Site HMO-C 1 -1.1874 0.4987 5.6683 0.0173

PctPoverty1_2 1 -0.0711 0.0401 3.1479 0.0760

PctPoverty1_3 1 0.00215 0.00130 2.7153 0.0994

DayCareHomeImpVal1 1 0.1492 0.0769 3.7660 0.0523

PreNatAlcohol_1 1 -0.3811 0.4729 0.6496 0.4203

PreNatFish_1 1 -1.7895 1.0311 3.0118 0.0827

PreNatHomePro_1 1 -1.2085 1.0351 1.3631 0.2430

PreNatTuna_1 1 0.3886 0.2352 2.7291 0.0985

Association of Predicted Probabilities and Observed Responses

Percent Concordant 71.7 Somers' D 0.443

Percent Discordant 27.4 Gamma 0.447

Percent Tied 0.9 Tau-a 0.060

Pairs 73568 c 0.721
Abt Associates, Inc. Appendix B 41

Exhibit B.38. Motor tics (current): Parent Rating (lower = better)

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Response Variable Tc_PWeekMotorYN Tics Parent Motor This Week Yes/No

Model Fit Statistics

Intercept

Intercept and

Criterion Only Covariates

AIC 632.178 607.924

SC 637.120 775.957

-2 Log L 630.178 539.924

Testing Global Null Hypothesis: BETA=0

Test Chi-Square DF Pr > ChiSq

Likelihood Ratio 90.2542 33 <.0001

Score 100.6880 33 <.0001

Wald 73.2901 33 <.0001

Standard Wald

Parameter DF Estimate Error Chi-Square Pr > ChiSq

Intercept 1 -82.0971 89.0297 0.8503 0.3565

PreNatThimer 1 0.00256 0.0121 0.0450 0.8319

Exp07mos 1 -0.00095 0.0206 0.0021 0.9630

ChildAge 1 25.4362 29.4884 0.7441 0.3884

sexmale 1 0.6542 0.2502 6.8395 0.0089

ChdBWT_Grp 1 1 -0.2165 0.4216 0.2638 0.6075

ChdBWT_Grp 2 1 -0.8590 0.3076 7.7982 0.0052

MomIQ1 1 1 0.2668 0.3461 0.5944 0.4407

MomIQ1 2 1 0.0780 0.3156 0.0610 0.8049

HOME_TotalIndex 1 0.0103 0.0649 0.0252 0.8738

PctPoverty1 1 0.8538 0.3281 6.7719 0.0093

MomEduc 1 -0.2853 0.1545 3.4104 0.0648

SingleParent 1 -0.1587 0.3159 0.2523 0.6155

Site HMO-A 1 -1.3120 0.4610 8.0982 0.0044

Site HMO-B 1 -0.6861 0.4271 2.5805 0.1082

Site HMO-C 1 -1.0048 0.4509 4.9650 0.0259

ChildAge2 1 -2.8738 3.2318 0.7907 0.3739

ChildAge3 1 0.1082 0.1172 0.8517 0.3561

PctPoverty1_2 1 -0.1239 0.0454 7.4519 0.0063

PctPoverty1_3 1 0.00447 0.00156 8.2277 0.0041

C5APGARImpVal1 1 0.4748 0.3024 2.4654 0.1164

DayCareCentrImpVal1 1 0.2786 0.1072 6.7520 0.0094

EngOnly 1 -0.4773 0.2611 3.3404 0.0676

IronDef 1 0.9195 0.6343 2.1013 0.1472

MatADHD 1 1.3623 0.7494 3.3044 0.0691

MatSTUTTER 1 1.1499 0.9550 1.4499 0.2285

MatSpeechDel 1 0.9853 0.9655 1.0416 0.3075

PreNatFish_1 1 -0.7765 0.5427 2.0474 0.1525

PreNatHomePro_1 1 1.0448 0.4826 4.6868 0.0304

PreNatIllDrug 1 1.2981 0.7750 2.8058 0.0939

PreNatNicotine_1 1 1.2077 0.3449 12.2624 0.0005

PreNatOrgMerc_1 1 0.4473 0.2065 4.6945 0.0303

PreNatTuna_1 1 0.4285 0.2287 3.5096 0.0610

OlderSibs 1 -0.3318 0.2516 1.7394 0.1872

Association of Predicted Probabilities and Observed Responses

Percent Concordant 75.9 Somers' D 0.525

Percent Discordant 23.4 Gamma 0.528

Percent Tied 0.7 Tau-a 0.087

Pairs 88454 c 0.762
Abt Associates, Inc. Appendix B 42

Exhibit B.39. Phonics tics (current): Parent Rating (lower = better)

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Response Variable Tc_PWeekPhonicYN Tics Parent Phonic This Week Yes/No

Model Fit Statistics

Intercept

Intercept and

Criterion Only Covariates

AIC 681.917 691.092

SC 686.861 849.303

-2 Log L 679.917 627.092

Testing Global Null Hypothesis: BETA=0

Test Chi-Square DF Pr > ChiSq

Likelihood Ratio 52.8246 31 0.0086

Score 56.7112 31 0.0032

Wald 49.8846 31 0.0172

Standard Wald

Parameter DF Estimate Error Chi-Square Pr > ChiSq

Intercept 1 -41.8542 80.4942 0.2704 0.6031

PreNatThimer 1 -0.0136 0.0165 0.6810 0.4092

Exp07mos 1 0.00721 0.0186 0.1498 0.6987

ChildAge 1 13.7121 26.7991 0.2618 0.6089

sexmale 1 0.4455 0.2252 3.9134 0.0479

ChdBWT_Grp 1 1 -0.2883 0.4025 0.5132 0.4737

ChdBWT_Grp 2 1 -0.5802 0.2789 4.3286 0.0375

MomIQ1 1 1 0.2493 0.3192 0.6099 0.4348

MomIQ1 2 1 -0.1567 0.2986 0.2754 0.5998

HOME_TotalIndex 1 -0.0272 0.0597 0.2073 0.6489

PctPoverty1 1 0.2413 0.2558 0.8903 0.3454

MomEduc 1 -0.1833 0.1484 1.5254 0.2168

SingleParent 1 0.2228 0.2820 0.6244 0.4294

Site HMO-A 1 -0.9580 0.4577 4.3816 0.0363

Site HMO-B 1 -0.3258 0.4149 0.6165 0.4323

Site HMO-C 1 -0.1582 0.4132 0.1467 0.7018

ChildAge2 1 -1.5662 2.9501 0.2819 0.5955

ChildAge3 1 0.0590 0.1074 0.3017 0.5828

PctPoverty1_2 1 -0.0310 0.0334 0.8591 0.3540

PctPoverty1_3 1 0.00103 0.00112 0.8493 0.3567

BFMthsCat 0 1 -0.0692 0.3083 0.0504 0.8223

BFMthsCat 1 1 0.1697 0.2573 0.4350 0.5095

cMedicalHist_1 1 0.6119 0.6751 0.8214 0.3648

DayCareCentrImpVal1 1 0.2581 0.0951 7.3585 0.0067

MatADHD 1 1.4105 0.6638 4.5146 0.0336

MatSpeechDel 1 1.2886 0.7119 3.2763 0.0703

PreNatAlcohol_1 1 -0.4250 0.3897 1.1894 0.2755

PreNatHomePro_1 1 0.6032 0.4685 1.6575 0.1979

PreNatIllDrug 1 0.8886 0.7992 1.2360 0.2662

PreNatNicotine_1 1 0.7761 0.3422 5.1446 0.0233

PreNatTuna_1 1 0.3242 0.2069 2.4538 0.1172

PreNatlead_1 1 0.3453 0.2895 1.4232 0.2329

Association of Predicted Probabilities and Observed Responses

Percent Concordant 70.8 Somers' D 0.424

Percent Discordant 28.4 Gamma 0.428

Percent Tied 0.8 Tau-a 0.077

Pairs 97860 c 0.712
Abt Associates, Inc. Appendix B 43

Exhibit B.40. WASI Verbal IQ

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: IF_VIQAvSS WASI Verbal IQ Scaled

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 31 70339.9524 2269.0307 15.18 <.0001

Error 1000 149465.0089 149.4650

Corrected Total 1031 219804.9612

R-Square Coeff Var Root MSE IF_VIQAvSS Mean

0.320011 11.38454 12.22559 107.3876

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept 102.3460987 B 8.94082484 11.45 <.0001

PreNatThimer 0.0535105 0.04671153 1.15 0.2523

Exp07mos -0.0436742 0.06571154 -0.66 0.5064

ChildAge 0.3311707 0.36731073 0.90 0.3675

sexmale -2.3432497 0.78649202 -2.98 0.0030

ChdBWT_Grp 1 -2.7505016 B 1.54425466 -1.78 0.0752

ChdBWT_Grp 2 1.4085207 B 1.09085945 1.29 0.1969

ChdBWT_Grp 3 0.0000000 B . . .

ComputerExpr 0 -4.2210606 B 3.95377977 -1.07 0.2860

ComputerExpr 1 -2.6140885 B 0.79918877 -3.27 0.0011

ComputerExpr 2 0.0000000 B . . .

MomIQ1 1 -6.7397340 B 1.16246183 -5.80 <.0001

MomIQ1 2 -4.3345386 B 1.02837008 -4.21 <.0001

MomIQ1 3 0.0000000 B . . .

HOME_TotalIndex 0.6350195 0.21947084 2.89 0.0039

PctPoverty1 0.3447060 0.17081948 2.02 0.0439

MomEduc 0 -2.8576237 B 2.07254249 -1.38 0.1683

MomEduc 1 -3.5666651 B 1.25585314 -2.84 0.0046

MomEduc 2 -1.8513792 B 0.96241720 -1.92 0.0547

MomEduc 3 0.0000000 B . . .

SingleParent -2.1451428 1.05068510 -2.04 0.0414

Site HMO-A -6.7637870 B 1.69332611 -3.99 <.0001

Site HMO-B -7.5748088 B 1.62213553 -4.67 <.0001

Site HMO-C -3.9116160 B 1.64599728 -2.38 0.0177

Site HMO-D 0.0000000 B . . .

BFMthsCat 0 -6.5295375 B 1.10946757 -5.89 <.0001

BFMthsCat 1 -5.8966448 B 0.91849497 -6.42 <.0001

BFMthsCat 2 0.0000000 B . . .

OlderSibs -4.4565025 0.89831165 -4.96 <.0001

YoungerSibs -2.5875351 0.86816695 -2.98 0.0029

C5APGARImpVal1 1.6493997 0.78376385 2.10 0.0356

PreNatFish_1 -3.0625838 1.57485029 -1.94 0.0521

EngOnly -1.7502633 0.86170762 -2.03 0.0425

ADHDstimulant -16.6942522 8.91509022 -1.87 0.0614

MatSTUTTER 6.6367855 3.72966646 1.78 0.0755

ChdPICA_1 1.9641535 1.93632017 1.01 0.3106

DayCareCentrImpVal1 0.5907421 0.39313822 1.50 0.1332

MatLangDel -10.1424110 5.61037825 -1.81 0.0709
Abt Associates, Inc. Appendix B 44

Exhibit B.41. WASI Performance IQ

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: IF_PIQAvSS WASI Performance IQ Scaled

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 27 44601.4758 1651.9065 8.46 <.0001

Error 1010 197282.8209 195.3295

Corrected Total 1037 241884.2967

R-Square Coeff Var Root MSE IF_PIQAvSS Mean

0.184392 13.30294 13.97603 105.0597

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept 106.5245799 B 6.00574563 17.74 <.0001

PreNatThimer -0.0081189 0.05413295 -0.15 0.8808

Exp07mos 0.1300492 0.07432953 1.75 0.0805

ChildAge 0.4727451 0.41689627 1.13 0.2571

sexmale 1.7403544 0.89498663 1.94 0.0521

ChdBWT_Grp 1 -3.4050694 B 1.77566680 -1.92 0.0554

ChdBWT_Grp 2 0.1479939 B 1.24625879 0.12 0.9055

ChdBWT_Grp 3 0.0000000 B . . .

ComputerExpr 0 -5.8280614 B 4.51730333 -1.29 0.1973

ComputerExpr 1 -1.8968479 B 0.90693500 -2.09 0.0367

ComputerExpr 2 0.0000000 B . . .

MomIQ1 1 -6.3850938 B 1.32170716 -4.83 <.0001

MomIQ1 2 -5.7185365 B 1.16538592 -4.91 <.0001

MomIQ1 3 0.0000000 B . . .

HOME_TotalIndex 0.3412097 0.24943775 1.37 0.1716

PctPoverty1 0.1310969 0.18867038 0.69 0.4873

MomEduc 0 -3.6761714 B 2.35873345 -1.56 0.1194

MomEduc 1 -2.3723087 B 1.43955910 -1.65 0.0997

MomEduc 2 -3.0893860 B 1.09452186 -2.82 0.0049

MomEduc 3 0.0000000 B . . .

SingleParent -1.8845599 1.18607628 -1.59 0.1124

Site HMO-A -1.6396731 B 1.93999483 -0.85 0.3982

Site HMO-B -5.4898285 B 1.87489729 -2.93 0.0035

Site HMO-C -2.4757801 B 1.89936705 -1.30 0.1927

Site HMO-D 0.0000000 B . . .

BFMthsCat 0 -5.2129704 B 1.26206240 -4.13 <.0001

BFMthsCat 1 -1.3901906 B 1.04336627 -1.33 0.1830

BFMthsCat 2 0.0000000 B . . .

EngOnly -2.6619835 0.98003214 -2.72 0.0067

YoungerSibs -1.6993815 0.90462924 -1.88 0.0606

PreNatFish_1 -3.4984420 1.77419929 -1.97 0.0489

ADHDstimulant -15.6114736 9.97203939 -1.57 0.1178

DayCareCentrImpVal1 0.5912127 0.44335012 1.33 0.1827

IronDef_1 -4.3923202 3.05698398 -1.44 0.1511
Abt Associates, Inc. Appendix B 45

Exhibit B.42. WASI Full Scale IQ

Results from Model: Y = B0+B1(PreNatThimer) + B2(Exp07mos) + covariates + e

Dependent Variable: IF_FSIQAvSS WASI Full Scale IQ Scaled

Sum of

Source DF Squares Mean Square F Value Pr > F

Model 37 65937.8343 1782.1036 11.64 <.0001

Error 987 151126.0154 153.1165

Corrected Total 1024 217063.8498

R-Square Coeff Var Root MSE IF_FSIQAvSS Mean

0.303772 11.55377 12.37403 107.0995

Standard

Parameter Estimate Error t Value Pr > |t|

Intercept 126.5250000 B 295.2550573 0.43 0.6684

PreNatThimer 0.0257707 0.0483595 0.53 0.5942

Exp07mos 0.0590716 0.0677106 0.87 0.3832

ChildAge -13.3981491 98.3375142 -0.14 0.8917

sexmale -0.3697602 0.8020110 -0.46 0.6449

ChdBWT_Grp 1 -2.9642046 B 1.5809743 -1.87 0.0611

ChdBWT_Grp 2 0.9084395 B 1.1076961 0.82 0.4123

ChdBWT_Grp 3 0.0000000 B . . .

ComputerExpr 0 -5.7208476 B 4.0082475 -1.43 0.1538

ComputerExpr 1 -2.4815095 B 0.8116904 -3.06 0.0023

ComputerExpr 2 0.0000000 B . . .

MomIQ1 1 -7.2942423 B 1.1903565 -6.13 <.0001

MomIQ1 2 -5.5903890 B 1.0468613 -5.34 <.0001

MomIQ1 3 0.0000000 B . . .

HOME_TotalIndex 0.5147310 0.2250700 2.29 0.0224

PctPoverty1 0.1850712 0.4327731 0.43 0.6690

MomEduc 0 -3.5457936 B 2.1548314 -1.65 0.1002

MomEduc 1 -3.1642046 B 1.2974352 -2.44 0.0149

MomEduc 2 -2.7339995 B 0.9816084 -2.79 0.0055

MomEduc 3 0.0000000 B . . .

SingleParent -1.9804963 1.0872939 -1.82 0.0688

Site HMO-A -4.6207417 B 1.7446498 -2.65 0.0082

Site HMO-B -7.4550436 B 1.6848308 -4.42 <.0001

Site HMO-C -3.6119417 B 1.7136397 -2.11 0.0353

Site HMO-D 0.0000000 B . . .

BFMthsCat 0 -6.6338037 B 1.1385119 -5.83 <.0001

BFMthsCat 1 -4.0456842 B 0.9386322 -4.31 <.0001

BFMthsCat 2 0.0000000 B . . .

OlderSibs -2.6768638 0.9164350 -2.92 0.0036

YoungerSibs -2.4191530 0.8954875 -2.70 0.0070

EngOnly -2.2981340 0.8870243 -2.59 0.0097

PreNatFish_1 -3.6722147 1.5981722 -2.30 0.0218

ADHDstimulant -17.2261068 9.0720797 -1.90 0.0579

C5APGARImpVal1 1.3444659 0.7986080 1.68 0.0926

DayCareCentrImpVal1 0.5742312 0.4007232 1.43 0.1522

IronDef_1 -4.0302041 2.7210356 -1.48 0.1389

MatSTUTTER 4.4806668 3.7921706 1.18 0.2377

MatLangDel -3.3088872 6.4343109 -0.51 0.6072

MatADHD -4.1424889 3.6879966 -1.12 0.2616

PreNatNicotine_1 -1.4609275 1.5224023 -0.96 0.3375

DayCareHomeImpVal1 -0.2410973 0.2810925 -0.86 0.3913

PctPoverty1_2 0.0054006 0.0252076 0.21 0.8304

ChildAge2 2.1506831 10.8327569 0.20 0.8427

ChildAge3 -0.1005009 0.3947896 -0.25 0.7991
Abt Associates, Inc. Appendix C 46

3. Appendix C. Model Checking with Partial-Partial

Residual Plots

This appendix presents results of model diagnostic procedures and results of analyses that

were conducted to assess the sensitivity of model results to points of potentially high

influence. The primary diagnostic procedures employed was the production of partialpartial residual plots, which are useful for identification of observations that may be

outliers, points of high leverage, or points of high influence. We also ran additional

diagnostic procedures to evaluate whether there were any problems with

multicollinearity. Since no problems with multicollinearity were indicated, those analyses

are not presented.

Partial-partial residual plot diagnostics were produced separately for each of the three

main exposure measures of interest: HepB 2and PreNatThimer3, and the Exp07mos4

exposure measures. And separate plots were created for males and females. Diagnostics,

were conducted for the Exp17mos5 measure of postnatal exposure but are not shown here

because they were very similar to those for the Exp07mos measure.

Using the HepB exposure measure as an example, we now explain the steps involved in

the production of a partial-partial residual plot. Each partial-partial residual plot was

created in three steps. First, residuals6 were obtained from a regression model that is the

same as the main effects model specified in Section 9.2.2.2, except that the HepB term is

omitted, and the model was fit to data from only one sex (boys or girls). In the second

step, the residuals were obtained from the same model, except where the outcome

variable is the HepB variable. In the third step, a scatter plot was created using the

residual values from the first step plotted along the y-axis, and the residuals from the

second step plotted along the x-axis.

Overlaid on each partial-partial plot is a linear regression line showing the slope of the

exposure effect, (e.g., the HepB effect), and a nonparametric scatter plot smoothing

curve. The simple linear regression of the residuals from the first step on the residuals

from the second step gives a slope for the exposure effect that is identical to the estimated

effect from the main analytic model fit to data from only one sex.

2 The HepB variable is a measure of cumulative exposure to mecury from thimerosal in vaccines and

immune globulins for the age range spanning birth through 28 days. The cumulative measure is divided by

the child’s body weight at the time of vaccine receipt. The variable is called HepB because most children

that had any exposure during this age range were exposed via receipt of the Hepatitis B vaccine. Several

children also received Hepatitis B immune globulins during this age range. Their values in the HepB

variable are much higher. For details on the coding of the HepB variable, see Chapter 7.

3 PreNatThimer is a measure of prenatal exposure to ethylmercury. See Chapter 7 for details.

4 Exp07mos is a measure of cumulative exposure to ethylmercury during the age range of birth to 7 months

(1-214 days). See Chapter 7 for details.

5 Exp07mos is a measure of cumulative exposure to ethylmercury during the age range of birth to 7 months

(1-214 days). See Chapter 7 for details.

6 A residual is the difference between an observed value and a predicted value from the model.
Abt Associates, Inc. Appendix C 47

The plots indicate that,

 For HepB:

o The distribution of the HepB exposure variable has an extremely long tail,

making the HepB estimates susceptible to influence by a small number of

very high leverage observations.

 For PreNatThimer:

o The distribution of the PreNatThimer exposure variable has an extremely

long tail, making the PreNatThimer estimates susceptible to influence by a

small number of very high leverage observations.

 For Exp07mos:

o The distribution of the Exp07mos exposure measure does not have

extremely long tails. There is little potential for an observation to have a

unusually high degree of leverage, and therefore estimates for Exp07mos

are unlikely to be unduly influenced a small number of highly influential

observations.

3.1. Partial-partial Plots for HepB Effects

Plots are shown for all outcome measures in the same order as they appear in the model

results summary tables in Chapter 9 of Volume I of the Technical Report. The first plot

shown in the upper left-hand panel of Exhibit B.1 shows the partial-partial plot for the

HepB effect for the Boston Naming Test for females. The y- and x-axes of the plots

correspond to outcome and exposures, respectively. A residual shown, for example, as

being high along the y-axis dimension indicates someone who scored higher on the

outcome measure than expected, given the person’s age, sex, family demographics and

all other covariates. And a residual that is far to the right along the x-axis indicates a

person who had higher than expected values on the HepB measure of exposure, given the

person’s age, sex, family demographics and all other covariates. The plot shows two

dominant swarms of points that are residuals from individuals who had either of the two

typical HepB exposure amounts – the leftmost swarm being the children who received

zero exposure in the first month of life, and the large swarm shown to the right

representing children that received 12.5 micrograms of mercury from a single hepatitis-b

vaccine received in the first month of life.

The plot shows that there are a few points appearing out to the right of the dominant

swarms of points. These are the residuals of high-exposure individuals that received a

hepatitis-b immune globulin in addition to a hepatitis-b vaccine, or received two

hepatitis-b vaccines in the first month of life.

A residual that is far from the mean along the x-axis (e.g. a high exposure individual) has

high leverage. To understand the term “leverage” think of a see-saw where the fulcrum is

not in the center, but is instead, much closer to one end than the other. A light person on

the long end of the see-saw can lift a heavy person on the short end by applying relatively

little force because the person on the long end has leverage working for them. On the

residual plot, imagine that the HepB slope is the see-saw and the fulcrum is placed at the
Abt Associates, Inc. Appendix C 48

mean of HepB along the x-axis. The fulcrum would be located on the x-axis around zero.

An individual that is far from the fulcrum will have high leverage on the HepB see-saw.

A residual that is far from the regression line in the y-axis direction has high distance.

The greater the distance, the greater the force exerted on the see-saw. To understand why

distance is related to the force exerted on the slope of the regression line, recall that the

algorithm for finding the slope of a regression line minimizes the sum of squared

distances of the residuals. A point that is far from the regression line will have a large

value of its squared distance. The algorithm will try to reduce that squared distance by

moving the regression line closer to the distant point.

A residual that is both high leverage (far from the mean on the x-axis), and high distance

(exerts a lot of force on the slope) is likely to be a point of high influence. A point of high

influence has much more weight than other points in determining the slope of the

regression line. In the plot in the upper left-hand panel of Exhibit B.1, the point that is

the farthest to the right, and well above the mean (the mean of residuals is zero and is

indicated by a horizontal dotted line), could potentially be exerting a great deal of

influence on the slope of the regression line for the HepB effect. However, in this

example, the point that is similarly far out to the right on the x-axis, but just below the

mean is likely to be counteracting the effect of the former.

Binary outcomes such as the Parent Reported Motor Tics outcome, shown in the middle

panel of Exhibit B.13, were analyzed in a logistic regression models. The plots

corresponding to binary outcomes are not residual plots, but rather are simply plots of the

outcome value (1=tics present, 0= tics absent) against the values of the HepB exposure

measure 7. The plot for Parent Reported Motor Tics shows that none of the high exposure

females had parent reported motor tics. This plot alerts us to the concern that this small

handful of high exposure individuals may have been overly influential in producing the

statistically significant estimate of a beneficial HepB effect in females.

Exhibit B.7 shows residual plots from Finger Tapping outcome measures where model

results indicated beneficial HepB effects for males. A single individual that had very high

scores on the finger tapping assessments is indicated with a filled diamond-shaped

plotting symbol. It has been verified that this individual’s very high score is a real score

and is not the result of a data entry error. This was not a high exposure individual.

However, since his score was so much higher than the scores of all other individuals, this

one particular child’s data may have been influential in producing the estimate of the

beneficial HepB effect.

7 The plot shows “jittered” values of outcome variable along the y-axis. Possible values for motor tics are

zero or one. If the zero/one values were plotted, the plotting symbols would tend to lie on top of one

another so that many could not be seen. “Jittered” values are obtained by adding a small, random number to

the value. Each jittered value is slightly different than zero or one. This allows more of the individual

plotting symbols to be in view.
Abt Associates, Inc. Appendix C 49

3.2. Partial-partial plots for PreNatThimer Effects

Partial-partial residual plots for PreNatThimer effects are shown in Exhibits B.15–B.28.

Similar to the HepB exposure measure, there were a few individuals with PreNatThimer

exposure measures that were much higher that then the rest. The distribution of this

variable is cause for concern because a few unusual observations could be highly

influential on the regression slope.

3.3. Partial-partial plots for Exp17mos Effects

Exhibits B.29 – B.42 indicate that the distribution of the Exp17mos measure is such that

it would be unlikely to find a single or just a few high leverage observations with the

potential to exert undue influence on the estimated slope.

3.4. Sensitivity Testing

The partial-partial residual plots made obvious the unevenness of the distributions of the

PreNatThimer and HepB exposure measures. The plots showed a small number of cases

with PreNatThimer and HepB values that strayed very far from the mean values. Those

high leverage cases have the potential to have a great deal of influence on the estimated

exposure effects. The plots also identified an individual male that had typical exposure

values, but who had unusually high scores on the finger tapping tests.

In their chapter on regression diagnostics, Bollen and Jackman (1990) make the argument

that:

“Regression analysis is a powerful tool in social research because it helps to identify

and summarize relations between variables. The emphasis on generalization is

critical: Among the many assumptions that statistical analysis involves is the idea that

a minority of observations does not drive the results. We are justly skeptical of

empirical results that are unduly sensitive to one case (or to a very small number of

observations).”

The argument articulated above motivates analyses to evaluate the sensitivity of the

model results to the high leverage observations identified in the partial-partial residual

plots. In order to assess sensitivity of the model results to the high-leverage observations,

we compared the results of the following three sets of models. The first set of models

was fit to the full data set, as reported in Chapter 9 of Volume I of the Technical Report.

The second set of models was identical to the first except that data from a single

individual was omitted from the analysis. This individual was the male, identified in the

partial-partial residual plots, that had unusually high values on the finger tapping

measures. As will be shown subsequently, the estimated HepB exposure effects for were

not particularly sensitive to the inclusion or omission of this one individual.
Abt Associates, Inc. Appendix C 50

The approach in the third set of models was to truncate the distributions of the HepB and

PreNatThimer measures so that neither had a long tail, and then to re-fit the set of sex-byexposure interaction models with the truncated exposure measures substituted in place of

the original measures.

The truncated version of PreNatThimer was created by recoding the 13 observations that

had very high values of 50, 62.75, or 100 to the more frequently occurring value of 25.

The truncated version of the HepB measure was created by simply making a dichotomous

(yes/no) variable which takes the value “1” if the child had any thimerosal exposure

during the age range from birth through 28 days of life, and takes the value “0” if there

was no exposure. We will refer to both the original HepB variable, and the truncated

(yes/no coded) version as “Month-1 exposure variables”.

In this set of models the handful of high exposure children have no greater leverage on

the regression slopes than children that had typical exposure amounts. These models may,

of course, underestimate exposure effects because they reduce the variation of the

exposure measures. Nonetheless, they may help us understand the influence of the high

leverage points on the results. These models were of the same form as specified for the

sex-by-exposure interaction (Section 9.2.3.2, Model 2, Volume I of Technical Report )

except that the truncated prenatal and Month-1 exposure variables (named PN_Trunc and

HepB_YN) replaced the originally coded prenatal and Month-1 exposure variables

(PreNatThimer and HepB).

It should be noted that the very high leverage observations are just as likely to hide

effects as to cause them. If a few very high exposure individuals had near average scores

on a particular outcome measure, then their influence could be to draw the regression

slope toward zero, thus potentially hiding exposure effects. The strategy of fitting models

to the data with truncated exposure variables could potentially illuminate exposure effects

that would be otherwise hidden due to high-leverage, but average scoring high exposure

individuals.

3.4.1. Results

The estimated effects of HepB exposure on the finger tapping tests for males were not

particularly sensitive to the inclusion or omission of the male with the extremely high

scores. In the full data set that included the male the estimates, standard errors, and pvalues for HepB effects on Finger Tapping Dominant Hand, were 0.41 (0.14), p=0.004,

and for Finger Tapping Non-dominant Hand were 0.27 (0.13), p=0.038. After removal

of the male with the unusual score the corresponding results were 0.37 (0.13), p=0.006

for Finger Tapping Dominant Hand, and 0.25 (0.12), p=0.046 for Finger Tapping Nondominant Hand.

The results from the models with the truncated prenatal and Month-1 exposure variables

are summarized in Exhibits B.43 and B.44. By comparing to the results from the models
Abt Associates, Inc. Appendix C 51

with the original coding of the exposure variables, shown in Exhibits 9.2.3.1 and 9.2.3.2

of Volume I of the Technical Report, we conclude that the estimates were not overly

sensitive to the effects of the high leverage and potentially high influence observations.

Although there are some minor differences, the pattern of results looks similar in the two

sets of summaries. In both there are small numbers of effects that are significant, some of

which are in the direction of benefit, others in the direction of harm.

For females, there were no significant prenatal effects using either the original coding or

the truncated prenatal exposure variable. Use of the truncated Month-1 exposure variable

tipped the estimate for neonatal exposure effects on the WASI full Scale IQ measure

below the p<0.05 criterion for statistical significance. With the original coding, it was a

little above the criterion, having a p-value of 0.098. The truncated coding also resulted in

a significant neonatal exposure effect on the NEPSY Speeded naming test that was not

significant with the originally coded variable. This result was in the direction of harm.

For males, however, the truncated prenatal exposure measure resulted in a significant

beneficial effect of prenatal exposure on the NEPSY Speeded naming outcome measure.

For males, the use of the truncated Month-1 exposure variable resulted in three additional

test results that fell below the p<0.05 criterion for statistical significance. All were in the

direction of high exposure being related to better outcomes.
Abt Associates, Inc. Appendix C 52

Exhibit B.1. Partial-partial Residual Plots: HepB

Females

Residuals from

Model minus HepB

-2 0 2 4 6 8

-15 -5 0 5 10 15

Boston Naming Test

Residuals from Model with HepB as Outcome Measure

Males

-2 0 2 4 6 8

-15 -5 0 5 10 15

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure

Females

Residuals from

Model minus HepB

-2 0 2 4 6 8

-20 -10 0 10

NEPSY: Speeded Naming

Residuals from Model with HepB as Outcome Measure

Males

-2 0 2 4 6 8

-20 -10 0 10

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure

Females

Residuals from

Model minus HepB

-2 0 2 4 6 8

-10 -5 0 5

NEPSY: Comprehension of Instructions

Residuals from Model with HepB as Outcome Measure

Males

-2 0 2 4 6 8

-10 -5 0 5

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure
Abt Associates, Inc. Appendix C 53

Exhibit B.2. Partial-partial Residual Plots: HepB

Females

Residuals from

Model minus HepB

-2 0 2 4 6 8

-20 -10 0 10

CELF: Formulated Sentences

Residuals from Model with HepB as Outcome Measure

Males

-2 0 2 4 6 8

-20 -10 0 10

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure

Females

Residuals from

Model minus HepB

-4 -2 0 2 4 6 8

-30 -10 0 10 20 30

CELF: Recalling Sentences

Residuals from Model with HepB as Outcome Measure

Males

-4 -2 0 2 4 6 8

-30 -10 0 10 20 30

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure

Females

Residuals from

Model minus HepB

-2 0 2 4 6 8

0 5 10 15

GFTA: Articulation (lower = better)

Residuals from Model with HepB as Outcome Measure

Males

-2 0 2 4 6 8

0 5 10 15

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure
Abt Associates, Inc. Appendix C 54

Exhibit B.3. Partial-partial Residual Plots: HepB

Females

Stuttering: Assessor Rating (lower = better)

0 2 4 6 8 10 12

0=No

1=Yes

Stuttering: Assessor Rating (lower = better)

HepB (Exposure 0-28 days)

Males

0 2 4 6 8 10 12

0=No

1=Yes

Regression Line

Scatterplot Smoother

Horizontal Line at Mean

HepB (Exposure 0-28 days)

Females

Stuttering: Parent Rating (lower = better)

0 2 4 6 8 10 12

0=No

1=Yes

Stuttering: Parent Rating (lower = better)

HepB (Exposure 0-28 days)

Males

0 2 4 6 8 10 12

0=No

1=Yes

Regression Line

Scatterplot Smoother

Horizontal Line at Mean

HepB (Exposure 0-28 days)

Females

Stuttering: Teacher Rating (lower = better)

0 2 4 6 8 10 12

0=No

1=Yes

Stuttering: Teacher Rating (lower = better)

HepB (Exposure 0-28 days)

Males

0 2 4 6 8 10 12

0=No

1=Yes

Regression Line

Scatterplot Smoother

Horizontal Line at Mean

HepB (Exposure 0-28 days)
Abt Associates, Inc. Appendix C 55

Exhibit B.4. Partial-partial Residual Plots: HepB

Females

Residuals from

Model minus HepB

-2 0 2 4 6 8

-30 -10 0 10 20 30

CVLT-C: Free Recall, No Delay

Residuals from Model with HepB as Outcome Measure

Males

-2 0 2 4 6 8

-30 -10 0 10 20 30

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure

Females

Residuals from

Model minus HepB

-2 0 2 4 6 8

-10 -5 0 5

CVLT-C: Free Recall, Short Delay

Residuals from Model with HepB as Outcome Measure

Males

-2 0 2 4 6 8

-10 -5 0 5

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure

Females

Residuals from

Model minus HepB

-2 0 2 4 6 8

-8 -6 -4 -2 0 2 4 6

CVLT-C: Cued Recall, No Delay

Residuals from Model with HepB as Outcome Measure

Males

-2 0 2 4 6 8

-8 -6 -4 -2 0 2 4 6

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure
Abt Associates, Inc. Appendix C 56

Exhibit B.5. Partial-partial Residual Plots: HepB

Females

Residuals from

Model minus HepB

-2 0 2 4 6 8

-10 -5 0 5

CVLT-C: Free Recall, Long Delay

Residuals from Model with HepB as Outcome Measure

Males

-2 0 2 4 6 8

-10 -5 0 5

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure

Females

Residuals from

Model minus HepB

-2 0 2 4 6 8

-8 -6 -4 -2 0 2 4 6

CVLT-C: Cued Recall, Long Delay

Residuals from Model with HepB as Outcome Measure

Males

-2 0 2 4 6 8

-8 -6 -4 -2 0 2 4 6

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure

Females

Residuals from

Model minus HepB

-2 0 2 4 6 8

-40 -20 0 20

CMS Stories 1: Immediate Recall

Residuals from Model with HepB as Outcome Measure

Males

-2 0 2 4 6 8

-40 -20 0 20

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure
Abt Associates, Inc. Appendix C 57

Exhibit B.6. Partial-partial Residual Plots: HepB

Females

Residuals from

Model minus HepB

-2 0 2 4 6 8

-40 -20 0 20

CMS Stories 2: Delayed Recall

Residuals from Model with HepB as Outcome Measure

Males

-2 0 2 4 6 8

-40 -20 0 20

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure

Females

Residuals from

Model minus HepB

-2 0 2 4 6 8

-20 -10 0 10 20

WJIII: Letter-Word Identification

Residuals from Model with HepB as Outcome Measure

Males

-2 0 2 4 6 8

-20 -10 0 10 20

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure

Females

Residuals from

Model minus HepB

-4 -2 0 2 4 6 8

-50 0 50 100 150 200

Grooved Pegboard: Dominant hand (lower = better)

Residuals from Model with HepB as Outcome Measure

Males

-4 -2 0 2 4 6 8

-50 0 50 100 150 200

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure
Abt Associates, Inc. Appendix C 58

Exhibit B.7. Partial-partial Residual Plots: HepB

Females

Residuals from

Model minus HepB

-2 0 2 4 6 8

-50 0 50 100 150 200

Grooved Pegboard: Non-Dom hand (lower = better)

Residuals from Model with HepB as Outcome Measure

Males

-2 0 2 4 6 8

-50 0 50 100 150 200

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure

Females

Residuals from

Model minus HepB

-2 0 2 4 6 8

-20 0 20 40 60

Finger Tapping: Dominant Hand

Residuals from Model with HepB as Outcome Measure

Males

-2 0 2 4 6 8

-20 0 20 40 60

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure

Females

Residuals from

Model minus HepB

-2 0 2 4 6 8

-10 0 10 20 30 40

Finger Tapping: Non-Dominant Hand

Residuals from Model with HepB as Outcome Measure

Males

-2 0 2 4 6 8

-10 0 10 20 30 40

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure
Abt Associates, Inc. Appendix C 59

Exhibit B.8. Partial-partial Residual Plots: HepB

Females

Residuals from

Model minus HepB

-2 0 2 4 6 8

-15 -10 -5 0 5 10

Stanford Binet: Copying

Residuals from Model with HepB as Outcome Measure

Males

-2 0 2 4 6 8

-15 -10 -5 0 5 10

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure

Females

Residuals from

Model minus HepB

-2 0 2 4 6 8

-40 -30 -20 -10 0 10

GDS Vigilance Task: Correct Responses

Residuals from Model with HepB as Outcome Measure

Males

-2 0 2 4 6 8

-40 -30 -20 -10 0 10

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure

Females

Residuals from

Model minus HepB

-2 0 2 4 6 8

-50 0 50 100

GDS Vigilance Task: Errors (lower = better)

Residuals from Model with HepB as Outcome Measure

Males

-2 0 2 4 6 8

-50 0 50 100

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure
Abt Associates, Inc. Appendix C 60

Exhibit B.9. Partial-partial Residual Plots: HepB

Females

Residuals from

Model minus HepB

-4 -2 0 2 4 6 8

-4 -2 0 2 4 6

WISC III: Digit Span, Forward Recall

Residuals from Model with HepB as Outcome Measure

Males

-4 -2 0 2 4 6 8

-4 -2 0 2 4 6

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure

Females

Residuals from

Model minus HepB

-4 -2 0 2 4 6 8

-4 -2 0 2 4 6 8

WISC III: Digit Span, Backward Recall

Residuals from Model with HepB as Outcome Measure

Males

-4 -2 0 2 4 6 8

-4 -2 0 2 4 6 8

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure

Females

Residuals from

Model minus HepB

-2 0 2 4 6 8

-5 0 5 10

WISC III: Digit Span, Combined

Residuals from Model with HepB as Outcome Measure

Males

-2 0 2 4 6 8

-5 0 5 10

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure
Abt Associates, Inc. Appendix C 61

Exhibit B.10. Partial-partial Residual Plots: HepB

Females

Residuals from

Model minus HepB

-2 0 2 4 6 8

-40 -20 0 20 40

BRIEF Parent Rating: Metacognition (lower = better)

Residuals from Model with HepB as Outcome Measure

Males

-2 0 2 4 6 8

-40 -20 0 20 40

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure

Females

Residuals from

Model minus HepB

-2 0 2 4 6 8

-40 -20 0 20 40 60

BRIEF Teacher Rating: Metacognition (lower = better)

Residuals from Model with HepB as Outcome Measure

Males

-2 0 2 4 6 8

-40 -20 0 20 40 60

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure

Females

Residuals from

Model minus HepB

-2 0 2 4 6 8

-10 -5 0 5 10 15

CRS-R: Parent Rating: Hyperactive/Impulsive

Residuals from Model with HepB as Outcome Measure

Males

-2 0 2 4 6 8

-10 -5 0 5 10 15

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure
Abt Associates, Inc. Appendix C 62

Exhibit B.11. Partial-partial Residual Plots: HepB

Females

Residuals from

Model minus HepB

-2 0 2 4 6 8

-10 0 10 20

CRS-R: Teacher Rating: Hyperactive/Impulsive

Residuals from Model with HepB as Outcome Measure

Males

-2 0 2 4 6 8

-10 0 10 20

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure

Females

Residuals from

Model minus HepB

-2 0 2 4 6 8

-10 -5 0 5 10 15 20

CRS-R: Parent Rating: Inattentive

Residuals from Model with HepB as Outcome Measure

Males

-2 0 2 4 6 8

-10 -5 0 5 10 15 20

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure

Females

Residuals from

Model minus HepB

-4 -2 0 2 4 6 8

-10 0 10 20

CRS-R: Teacher Rating: Hyperactive/Impulsive

Residuals from Model with HepB as Outcome Measure

Males

-4 -2 0 2 4 6 8

-10 0 10 20

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure
Abt Associates, Inc. Appendix C 63

Exhibit B.12. Partial-partial Residual Plots: HepB

Females

Residuals from

Model minus HepB

-2 0 2 4 6 8

-20 0 10 20 30

BRIEF Parent Rating: Behavior Regulation

Residuals from Model with HepB as Outcome Measure

Males

-2 0 2 4 6 8

-20 0 10 20 30

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure

Females

Residuals from

Model minus HepB

-2 0 2 4 6 8

-20 0 20 40

BRIEF Teacher Rating: Behavior Regulation

Residuals from Model with HepB as Outcome Measure

Males

-2 0 2 4 6 8

-20 0 20 40

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure

Females

Motor tics (current): Assessor Rating

0 2 4 6 8 10 12

0=No

1=Yes

Motor tics (current): Assessor Rating

HepB (Exposure 0-28 days)

Males

0 2 4 6 8 10 12

0=No

1=Yes

Regression Line

Scatterplot Smoother

Horizontal Line at Mean

HepB (Exposure 0-28 days)
Abt Associates, Inc. Appendix C 64

Exhibit B.13. Partial-partial Residual Plots: HepB

Females

Phonics tics (current): Assessor Rating

0 2 4 6 8 10 12

0=No

1=Yes

Phonics tics (current): Assessor Rating

HepB (Exposure 0-28 days)

Males

0 2 4 6 8 10 12

0=No

1=Yes

Regression Line

Scatterplot Smoother

Horizontal Line at Mean

HepB (Exposure 0-28 days)

Females

Motor tics (current): Parent Rating

0 2 4 6 8 10 12

0=No

1=Yes

Motor tics (current): Parent Rating

HepB (Exposure 0-28 days)

Males

0 2 4 6 8 10 12

0=No

1=Yes

Regression Line

Scatterplot Smoother

Horizontal Line at Mean

HepB (Exposure 0-28 days)

Females

Phonics tics (current): Parent Rating

0 2 4 6 8 10 12

0=No

1=Yes

Phonics tics (current): Parent Rating

HepB (Exposure 0-28 days)

Males

0 2 4 6 8 10 12

0=No

1=Yes

Regression Line

Scatterplot Smoother

Horizontal Line at Mean

HepB (Exposure 0-28 days)
Abt Associates, Inc. Appendix C 65

Exhibit B.14. Partial-partial Residual Plots: HepB

Females

Residuals from

Model minus HepB

-4 -2 0 2 4 6 8

-20 0 20 40

WASI Verbal IQ

Residuals from Model with HepB as Outcome Measure

Males

-4 -2 0 2 4 6 8

-20 0 20 40

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure

Females

Residuals from

Model minus HepB

-4 -2 0 2 4 6 8

-20 0 20 40

WASI Performance IQ

Residuals from Model with HepB as Outcome Measure

Males

-4 -2 0 2 4 6 8

-20 0 20 40

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure

Females

Residuals from

Model minus HepB

-2 0 2 4 6 8

-20 0 20 40

WASI Full Scale IQ

Residuals from Model with HepB as Outcome Measure

Males

-2 0 2 4 6 8

-20 0 20 40

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with HepB as Outcome Measure
Abt Associates, Inc. Appendix C 66

Exhibit B.15. Partial-partial Residual Plots: PreNatThimer

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-15 -5 0 5 10

Boston Naming Test

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-15 -5 0 5 10

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-20 -10 0 10

NEPSY: Speeded Naming

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-20 -10 0 10

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-10 -5 0 5

NEPSY: Comprehension of Instructions

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-10 -5 0 5

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure
Abt Associates, Inc. Appendix C 67

Exhibit B.16. Partial-partial Residual Plots: PreNatThimer

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-20 -10 0 10

CELF: Formulated Sentences

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-20 -10 0 10

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-30 -10 0 10 20 30

CELF: Recalling Sentences

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-30 -10 0 10 20 30

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

0 5 10 15

GFTA: Articulation (lower = better)

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

0 5 10 15

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure
Abt Associates, Inc. Appendix C 68

Exhibit B.17. Partial-partial Residual Plots: PreNatThimer

Females

Stuttering: Assessor Rating (lower = better)

0 2 4 6 8 10 12

0=No

1=Yes

Stuttering: Assessor Rating (lower = better)

PreNatThimer Exposure

Males

0 2 4 6 8 10 12

0=No

1=Yes

Regression Line

Scatterplot Smoother

Horizontal Line at Mean

PreNatThimer Exposure

Females

Stuttering: Parent Rating (lower = better)

0 2 4 6 8 10 12

0=No

1=Yes

Stuttering: Parent Rating (lower = better)

PreNatThimer Exposure

Males

0 2 4 6 8 10 12

0=No

1=Yes

Regression Line

Scatterplot Smoother

Horizontal Line at Mean

PreNatThimer Exposure

Females

Stuttering: Teacher Rating (lower = better)

0 2 4 6 8 10 12

0=No

1=Yes

Stuttering: Teacher Rating (lower = better)

PreNatThimer Exposure

Males

0 2 4 6 8 10 12

0=No

1=Yes

Regression Line

Scatterplot Smoother

Horizontal Line at Mean

PreNatThimer Exposure
Abt Associates, Inc. Appendix C 69

Exhibit B.18. Partial-partial Residual Plots: PreNatThimer

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-30 -10 0 10 20 30

CVLT-C: Free Recall, No Delay

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-30 -10 0 10 20 30

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-10 -5 0 5

CVLT-C: Free Recall, Short Delay

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-10 -5 0 5

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-8 -6 -4 -2 0 2 4 6

CVLT-C: Cued Recall, No Delay

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-8 -6 -4 -2 0 2 4 6

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure
Abt Associates, Inc. Appendix C 70

Exhibit B.19. Partial-partial Residual Plots: PreNatThimer

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-10 -5 0 5

CVLT-C: Free Recall, Long Delay

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-10 -5 0 5

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-8 -6 -4 -2 0 2 4 6

CVLT-C: Cued Recall, Long Delay

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-8 -6 -4 -2 0 2 4 6

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-40 -20 0 20

CMS Stories 1: Immediate Recall

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-40 -20 0 20

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure
Abt Associates, Inc. Appendix C 71

Exhibit B.20. Partial-partial Residual Plots: PreNatThimer

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-40 -20 0 20

CMS Stories 2: Delayed Recall

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-40 -20 0 20

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-20 -10 0 10 20

WJIII: Letter-Word Identification

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-20 -10 0 10 20

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-50 0 50 100 150 200

Grooved Pegboard: Dominant hand (lower = better)

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-50 0 50 100 150 200

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure
Abt Associates, Inc. Appendix C 72

Exhibit B.21. Partial-partial Residual Plots: PreNatThimer

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-50 0 50 100 150 200

Grooved Pegboard: Non-Dom hand (lower = better)

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-50 0 50 100 150 200

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-20 0 20 40 60

Finger Tapping: Dominant Hand

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-20 0 20 40 60

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-10 0 10 20 30 40

Finger Tapping: Non-Dominant Hand

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-10 0 10 20 30 40

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure
Abt Associates, Inc. Appendix C 73

Exhibit B.22. Partial-partial Residual Plots: PreNatThimer

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-15 -10 -5 0 5 10

Stanford Binet: Copying

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-15 -10 -5 0 5 10

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-40 -30 -20 -10 0 10

GDS Vigilance Task: Correct Responses

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-40 -30 -20 -10 0 10

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-50 0 50 100

GDS Vigilance Task: Errors (lower = better)

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-50 0 50 100

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure
Abt Associates, Inc. Appendix C 74

Exhibit B.23. Partial-partial Residual Plots: PreNatThimer

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-4 -2 0 2 4 6

WISC III: Digit Span, Forward Recall

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-4 -2 0 2 4 6

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-4 -2 0 2 4 6 8

WISC III: Digit Span, Backward Recall

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-4 -2 0 2 4 6 8

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-5 0 5 10

WISC III: Digit Span, Combined

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-5 0 5 10

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure
Abt Associates, Inc. Appendix C 75

Exhibit B.24. Partial-partial Residual Plots: PreNatThimer

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-40 -20 0 20 40

BRIEF Parent Rating: Metacognition (lower = better)

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-40 -20 0 20 40

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-40 -20 0 20 40 60

BRIEF Teacher Rating: Metacognition (lower = better)

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-40 -20 0 20 40 60

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-10 -5 0 5 10 15

CRS-R: Parent Rating: Hyperactive/Impulsive

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-10 -5 0 5 10 15

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure
Abt Associates, Inc. Appendix C 76

Exhibit B.25. Partial-partial Residual Plots: PreNatThimer

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-10 0 10 20

CRS-R: Teacher Rating: Hyperactive/Impulsive

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-10 0 10 20

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-10 -5 0 5 10 15 20

CRS-R: Parent Rating: Inattentive

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-10 -5 0 5 10 15 20

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-10 0 10 20

CRS-R: Teacher Rating: Hyperactive/Impulsive

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-10 0 10 20

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure
Abt Associates, Inc. Appendix C 77

Exhibit B.26. Partial-partial Residual Plots: PreNatThimer

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-20 0 10 20 30

BRIEF Parent Rating: Behavior Regulation

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-20 0 10 20 30

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-20 0 20 40

BRIEF Teacher Rating: Behavior Regulation

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-20 0 20 40

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure

Females

Motor tics (current): Assessor Rating

0 2 4 6 8 10 12

0=No

1=Yes

Motor tics (current): Assessor Rating

PreNatThimer Exposure

Males

0 2 4 6 8 10 12

0=No

1=Yes

Regression Line

Scatterplot Smoother

Horizontal Line at Mean

PreNatThimer Exposure
Abt Associates, Inc. Appendix C 78

Exhibit B.27. Partial-partial Residual Plots: PreNatThimer

Females

Phonics tics (current): Assessor Rating

0 2 4 6 8 10 12

0=No

1=Yes

Phonics tics (current): Assessor Rating

PreNatThimer Exposure

Males

0 2 4 6 8 10 12

0=No

1=Yes

Regression Line

Scatterplot Smoother

Horizontal Line at Mean

PreNatThimer Exposure

Females

Motor tics (current): Parent Rating

0 2 4 6 8 10 12

0=No

1=Yes

Motor tics (current): Parent Rating

PreNatThimer Exposure

Males

0 2 4 6 8 10 12

0=No

1=Yes

Regression Line

Scatterplot Smoother

Horizontal Line at Mean

PreNatThimer Exposure

Females

Phonics tics (current): Parent Rating

0 2 4 6 8 10 12

0=No

1=Yes

Phonics tics (current): Parent Rating

PreNatThimer Exposure

Males

0 2 4 6 8 10 12

0=No

1=Yes

Regression Line

Scatterplot Smoother

Horizontal Line at Mean

PreNatThimer Exposure
Abt Associates, Inc. Appendix C 79

Exhibit B.28. Partial-partial Residual Plots: PreNatThimer

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-20 0 20 40

WASI Verbal IQ

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-20 0 20 40

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-20 0 20 40

WASI Performance IQ

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-20 0 20 40

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure

Females

Residuals from

Model minus PreNatThimer

0 20 40 60 80

-20 0 20 40

WASI Full Scale IQ

Residuals from Model with PreNatThimer as Outcome Measure

Males

0 20 40 60 80

-20 0 20 40

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with PreNatThimer as Outcome Measure
Abt Associates, Inc. Appendix C 80

Exhibit B.29. Partial-partial Residual Plots: Exp07

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10 20

-15 -5 0 5 10 15

Boston Naming Test

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10 20

-15 -5 0 5 10 15

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10

-20 -10 0 10

NEPSY: Speeded Naming

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10

-20 -10 0 10

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10

-10 -5 0 5

NEPSY: Comprehension of Instructions

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10

-10 -5 0 5

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure
Abt Associates, Inc. Appendix C 81

Exhibit B.30. Partial-partial Residual Plots: Exp07

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10 20

-20 -10 0 10

CELF: Formulated Sentences

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10 20

-20 -10 0 10

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10 20

-30 -10 0 10 20 30

CELF: Recalling Sentences

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10 20

-30 -10 0 10 20 30

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10 20

0 5 10 15

GFTA: Articulation (lower = better)

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10 20

0 5 10 15

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure
Abt Associates, Inc. Appendix C 82

Exhibit B.31. Partial-partial Residual Plots: Exp07

Females

Stuttering: Assessor Rating (lower = better)

0 2 4 6 8 10 12

0=No

1=Yes

Stuttering: Assessor Rating (lower = better)

Exposure 0 to 7 months

Males

0 2 4 6 8 10 12

0=No

1=Yes

Regression Line

Scatterplot Smoother

Horizontal Line at Mean

Exposure 0 to 7 months

Females

Stuttering: Parent Rating (lower = better)

0 2 4 6 8 10 12

0=No

1=Yes

Stuttering: Parent Rating (lower = better)

Exposure 0 to 7 months

Males

0 2 4 6 8 10 12

0=No

1=Yes

Regression Line

Scatterplot Smoother

Horizontal Line at Mean

Exposure 0 to 7 months

Females

Stuttering: Teacher Rating (lower = better)

0 2 4 6 8 10 12

0=No

1=Yes

Stuttering: Teacher Rating (lower = better)

Exposure 0 to 7 months

Males

0 2 4 6 8 10 12

0=No

1=Yes

Regression Line

Scatterplot Smoother

Horizontal Line at Mean

Exposure 0 to 7 months
Abt Associates, Inc. Appendix C 83

Exhibit B.32. Partial-partial Residual Plots: Exp07

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10

-30 -10 0 10 20 30

CVLT-C: Free Recall, No Delay

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10

-30 -10 0 10 20 30

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10 20

-10 -5 0 5

CVLT-C: Free Recall, Short Delay

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10 20

-10 -5 0 5

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10

-8 -6 -4 -2 0 2 4 6

CVLT-C: Cued Recall, No Delay

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10

-8 -6 -4 -2 0 2 4 6

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure
Abt Associates, Inc. Appendix C 84

Exhibit B.33. Partial-partial Residual Plots: Exp07

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10

-10 -5 0 5

CVLT-C: Free Recall, Long Delay

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10

-10 -5 0 5

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10

-8 -6 -4 -2 0 2 4 6

CVLT-C: Cued Recall, Long Delay

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10

-8 -6 -4 -2 0 2 4 6

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10 20

-40 -20 0 20

CMS Stories 1: Immediate Recall

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10 20

-40 -20 0 20

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure
Abt Associates, Inc. Appendix C 85

Exhibit B.34. Partial-partial Residual Plots: Exp07

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10 20

-40 -20 0 20

CMS Stories 2: Delayed Recall

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10 20

-40 -20 0 20

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10 20

-20 -10 0 10 20

WJIII: Letter-Word Identification

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10 20

-20 -10 0 10 20

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10 20

-50 0 50 100 150 200

Grooved Pegboard: Dominant hand (lower = better)

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10 20

-50 0 50 100 150 200

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure
Abt Associates, Inc. Appendix C 86

Exhibit B.35. Partial-partial Residual Plots: Exp07

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10

-50 0 50 100 150 200

Grooved Pegboard: Non-Dom hand (lower = better)

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10

-50 0 50 100 150 200

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10

-20 0 20 40 60

Finger Tapping: Dominant Hand

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10

-20 0 20 40 60

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10 20

-10 0 10 20 30 40

Finger Tapping: Non-Dominant Hand

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10 20

-10 0 10 20 30 40

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure
Abt Associates, Inc. Appendix C 87

Exhibit B.36. Partial-partial Residual Plots: Exp07

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10

-15 -10 -5 0 5 10

Stanford Binet: Copying

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10

-15 -10 -5 0 5 10

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10

-40 -30 -20 -10 0 10

GDS Vigilance Task: Correct Responses

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10

-40 -30 -20 -10 0 10

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10

-50 0 50 100

GDS Vigilance Task: Errors (lower = better)

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10

-50 0 50 100

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure
Abt Associates, Inc. Appendix C 88

Exhibit B.37. Partial-partial Residual Plots: Exp07

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10

-4 -2 0 2 4 6

WISC III: Digit Span, Forward Recall

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10

-4 -2 0 2 4 6

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10 20

-4 -2 0 2 4 6 8

WISC III: Digit Span, Backward Recall

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10 20

-4 -2 0 2 4 6 8

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10 20

-5 0 5 10

WISC III: Digit Span, Combined

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10 20

-5 0 5 10

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure
Abt Associates, Inc. Appendix C 89

Exhibit B.38. Partial-partial Residual Plots: Exp07

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10 20

-40 -20 0 20 40

BRIEF Parent Rating: Metacognition (lower = better)

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10 20

-40 -20 0 20 40

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10

-40 -20 0 20 40 60

BRIEF Teacher Rating: Metacognition (lower = better)

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10

-40 -20 0 20 40 60

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10

-10 -5 0 5 10 15

CRS-R: Parent Rating: Hyperactive/Impulsive

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10

-10 -5 0 5 10 15

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure
Abt Associates, Inc. Appendix C 90

Exhibit B.39. Partial-partial Residual Plots: Exp07

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10 20

-10 0 10 20

CRS-R: Teacher Rating: Hyperactive/Impulsive

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10 20

-10 0 10 20

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10

-10 -5 0 5 10 15 20

CRS-R: Parent Rating: Inattentive

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10

-10 -5 0 5 10 15 20

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10

-10 0 10 20

CRS-R: Teacher Rating: Hyperactive/Impulsive

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10

-10 0 10 20

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure
Abt Associates, Inc. Appendix C 91

Exhibit B.40. Partial-partial Residual Plots: Exp07

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10

-20 0 10 20 30

BRIEF Parent Rating: Behavior Regulation

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10

-20 0 10 20 30

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10

-20 0 20 40

BRIEF Teacher Rating: Behavior Regulation

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10

-20 0 20 40

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure

Females

Motor tics (current): Assessor Rating

0 2 4 6 8 10 12

0=No

1=Yes

Motor tics (current): Assessor Rating

Exposure 0 to 7 months

Males

0 2 4 6 8 10 12

0=No

1=Yes

Regression Line

Scatterplot Smoother

Horizontal Line at Mean

Exposure 0 to 7 months
Abt Associates, Inc. Appendix C 92

Exhibit B.41. Partial-partial Residual Plots: Exp07

Females

Phonics tics (current): Assessor Rating

0 2 4 6 8 10 12

0=No

1=Yes

Phonics tics (current): Assessor Rating

Exposure 0 to 7 months

Males

0 2 4 6 8 10 12

0=No

1=Yes

Regression Line

Scatterplot Smoother

Horizontal Line at Mean

Exposure 0 to 7 months

Females

Motor tics (current): Parent Rating

0 2 4 6 8 10 12

0=No

1=Yes

Motor tics (current): Parent Rating

Exposure 0 to 7 months

Males

0 2 4 6 8 10 12

0=No

1=Yes

Regression Line

Scatterplot Smoother

Horizontal Line at Mean

Exposure 0 to 7 months

Females

Phonics tics (current): Parent Rating

0 2 4 6 8 10 12

0=No

1=Yes

Phonics tics (current): Parent Rating

Exposure 0 to 7 months

Males

0 2 4 6 8 10 12

0=No

1=Yes

Regression Line

Scatterplot Smoother

Horizontal Line at Mean

Exposure 0 to 7 months
Abt Associates, Inc. Appendix C 93

Exhibit B.42. Partial-partial Residual Plots: Exp07

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10 20

-20 0 20 40

WASI Verbal IQ

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10 20

-20 0 20 40

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10 20

-20 0 20 40

WASI Performance IQ

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10 20

-20 0 20 40

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure

Females

Residuals from

Model minus Exp07mos

-20 -10 0 10

-20 0 20 40

WASI Full Scale IQ

Residuals from Model with Exp07mos as Outcome Measure

Males

-20 -10 0 10

-20 0 20 40

Regression Line

Scatterplot Smoother

Horizontal Line at 0

Residuals from Model with Exp07mos as Outcome Measure
Abt Associates, Inc. Appendix C 94

Exhibit B.43. Summary of Thimerosal Effects when PreNatThimer is Truncated and HepB Coded as Yes/no – Females

E s t S .E . P S tC f E s t S .E . P S tC f E s t S .E . P S tC f

S p e e c h a n d L a n g u a g e

B o s to n N a m in g T e s t 0 .0 3 7 0 .0 4 6 0 .4 1 9 0 .0 2 6 -0 .6 7 2 0 .5 5 4 0 .2 2 6 -0 .0 3 8 0 .0 7 9 0 .0 4 2 0 .0 5 8 0 .0 6 6

N E P S Y : S p e e d e d N a m in g 0 .0 5 0 0 .0 5 7 0 .3 8 1 0 .0 3 5 -0 .1 3 0 0 .6 9 2 0 .8 5 1 -0 .0 0 7 0 .0 3 4 0 .0 5 3 0 .5 1 6 0 .0 2 8

N E P S Y : C o m p re h e n s io n o f In s tru c tio n s 0 .0 0 6 0 .0 2 0 0 .7 8 3 0 .0 1 1 S * -0 .5 7 5 0 .2 4 8 0 .0 2 1 * -0 .0 9 3 0 .0 0 3 0 .0 1 9 0 .8 7 7 0 .0 0 7

C E L F : F o rm u la te d S e n te n c e s 0 .0 2 0 0 .0 4 5 0 .6 5 3 0 .0 1 7 -0 .4 1 0 0 .5 4 4 0 .4 5 2 -0 .0 2 8 -0 .0 3 5 0 .0 4 1 0 .3 9 5 -0 .0 3 5

C E L F : R e c a llin g S e n te n c e s 0 .0 4 8 0 .0 9 4 0 .6 0 7 0 .0 1 9 -0 .5 4 4 1 .1 3 0 0 .6 3 0 -0 .0 1 7 0 .0 2 7 0 .0 8 6 0 .7 5 6 0 .0 1 2

G F T A : A rtic u la tio n (lo w e r = b e tte r) -0 .0 0 4 0 .0 1 4 0 .7 9 4 -0 .0 1 1 0 .2 4 7 0 .1 7 4 0 .1 5 8 0 .0 6 0 0 .0 0 1 0 .0 1 3 0 .9 4 5 0 .0 0 3

S tu tte rin g : A s s e s s o r R a tin g (lo w e r = b e tte r) 0 .0 4 3 0 .0 3 8 0 .2 4 9 1 .6 3 4 0 .1 7 4 0 .6 1 6 0 .7 7 8 1 .1 7 2 0 .0 3 0 0 .0 4 7 0 .5 2 9 1 .4 8 8

S tu tte rin g : P a re n t R a tin g (lo w e r = b e tte r) -0 .8 1 6 1 6 .4 6 7 0 .9 6 0 0 .0 0 0 -0 .5 7 1 0 .7 0 1 0 .4 1 5 0 .5 9 3 0 .0 4 9 0 .0 6 4 0 .4 4 0 1 .9 2 9

S tu tte rin g : T e a c h e r R a tin g (lo w e r = b e tte r) -0 .0 4 8 0 .0 5 2 0 .3 5 5 0 .5 8 0 S -0 .4 0 6 0 .4 6 0 0 .3 7 7 0 .6 8 9 0 .0 1 1 0 .0 3 9 0 .7 8 7 1 .1 5 2

V e r b a l M e m o ry

C V L T -C : F re e R e c a ll, N o D e la y 0 .0 4 9 0 .0 6 9 0 .4 8 2 0 .0 2 8 S -0 .9 2 9 0 .8 4 2 0 .2 7 0 -0 .0 4 4 0 .0 1 2 0 .0 6 4 0 .8 5 2 0 .0 0 8

C V L T -C : F re e R e c a ll, S h o rt D e la y 0 .0 0 6 0 .0 2 0 0 .7 4 5 0 .0 1 3 S * -0 .3 8 3 0 .2 3 9 0 .1 1 0 -0 .0 6 4 -0 .0 2 3 0 .0 1 8 0 .2 0 5 -0 .0 5 6

C V L T -C : C u e d R e c a ll, S h o rt D e la y -0 .0 1 2 0 .0 1 7 0 .4 7 4 -0 .0 2 9 S * -0 .2 2 8 0 .2 0 8 0 .2 7 3 -0 .0 4 4 -0 .0 0 6 0 .0 1 6 0 .7 0 8 -0 .0 1 6

C V L T -C : F re e R e c a ll, L o n g D e la y -0 .0 0 5 0 .0 1 8 0 .7 9 6 -0 .0 1 1 S * -0 .3 4 4 0 .2 2 1 0 .1 2 0 -0 .0 6 2 -0 .0 1 0 0 .0 1 7 0 .5 3 4 -0 .0 2 7

C V L T -C : C u e d R e c a ll, L o n g D e la y -0 .0 1 1 0 .0 1 8 0 .5 2 3 -0 .0 2 6 S * -0 .2 6 4 0 .2 1 6 0 .2 2 1 -0 .0 4 9 0 .0 0 4 0 .0 1 6 0 .8 1 8 0 .0 1 0

C M S S to rie s 1 : Im m e d ia te R e c a ll -0 .0 1 4 0 .0 8 9 0 .8 7 5 -0 .0 0 5 -0 .4 3 6 1 .0 8 1 0 .6 8 7 -0 .0 1 3 0 .0 3 8 0 .0 8 2 0 .6 4 7 0 .0 1 6

C M S S to rie s 2 : D e la y e d R e c a ll -0 .0 5 9 0 .0 8 8 0 .5 0 1 -0 .0 2 2 -1 .2 6 4 1 .0 6 4 0 .2 3 5 -0 .0 3 8 0 .0 6 1 0 .0 8 1 0 .4 5 3 0 .0 2 7

A c h ie v e m e n t

W J III: L e tte r- W o rd Id e n tific a tio n -0 .0 4 1 0 .0 5 5 0 .4 6 0 -0 .0 2 5 -0 .9 7 4 0 .6 6 9 0 .1 4 6 -0 .0 4 8 0 .0 3 0 0 .0 5 1 0 .5 5 2 0 .0 2 2

F in e M o to r C o o rd in a tio n

G ro o v e d P e g b o a rd : D o m in a n t H a n d (lo w e r = b e tte r) -0 .0 7 7 0 .1 3 6 0 .5 7 1 -0 .0 1 6 0 .0 2 9 1 .6 4 4 0 .9 8 6 0 .0 0 0 -0 .0 4 4 0 .1 2 3 0 .7 1 8 -0 .0 1 1

G ro o v e d P e g b o a rd : N o n -d o m H a n d (lo w e r = b e tte r) -0 .0 7 6 0 .1 6 4 0 .6 4 1 -0 .0 1 4 -0 .1 7 4 1 .9 9 2 0 .9 3 0 -0 .0 0 3 -0 .3 4 8 0 .1 5 1 0 .0 2 1 + -0 .0 7 3

F in g e r T a p p in g : D o m in a n t H a n d -0 .0 0 8 0 .0 4 6 0 .8 5 8 -0 .0 0 7 S * 0 .1 4 3 0 .5 6 4 0 .8 0 0 0 .0 1 0 0 .0 0 3 0 .0 4 3 0 .9 4 9 0 .0 0 3

F in g e r T a p p in g : N o n -d o m in a n t H a n d 0 .0 2 0 0 .0 4 2 0 .6 3 3 0 .0 1 8 S * -0 .6 6 3 0 .5 1 0 0 .1 9 4 -0 .0 4 8 0 .0 1 2 0 .0 3 9 0 .7 6 7 0 .0 1 2

V is u a l S p a tia l A b ility

S ta n fo rd B in e t: C o p y in g S * -0 .0 4 0 0 .0 2 3 0 .0 8 1 -0 .0 7 5 -0 .0 9 3 0 .2 7 6 0 .7 3 5 -0 .0 1 4 S 0 .0 3 4 0 .0 2 1 0 .1 0 8 0 .0 7 5

A tte n tio n /E x e c u tiv e F u n c tio n in g

G D S V ig ila n c e T a s k : C o rre c t R e s p o n s e s -0 .0 2 5 0 .0 3 8 0 .5 2 3 -0 .0 2 7 -0 .3 2 4 0 .4 6 7 0 .4 8 8 -0 .0 2 9 0 .0 5 0 0 .0 3 6 0 .1 5 9 0 .0 6 5

G D S V ig ila n c e T a s k : E rro rs (lo w e r = b e tte r) 0 .0 5 0 0 .0 9 9 0 .6 1 5 0 .0 2 1 0 .1 3 1 1 .2 0 6 0 .9 1 4 0 .0 0 5 -0 .1 2 1 0 .0 9 2 0 .1 9 0 -0 .0 6 0

W IS C III: D ig it S p a n , F o rw a rd R e c a ll -0 .0 1 7 0 .0 1 4 0 .2 3 9 -0 .0 5 0 -0 .0 2 4 0 .1 7 3 0 .8 9 1 -0 .0 0 6 -0 .0 0 4 0 .0 1 3 0 .7 6 7 -0 .0 1 4

W IS C III: D ig it S p a n , B a c k w a rd R e c a ll 0 .0 0 0 0 .0 1 2 0 .9 8 0 0 .0 0 1 -0 .0 0 7 0 .1 5 1 0 .9 6 4 -0 .0 0 2 0 .0 2 6 0 .0 1 1 0 .0 2 4 + 0 .1 0 4

W IS C III: D ig it S p a n , C o m b in e d -0 .0 1 6 0 .0 2 2 0 .4 8 1 -0 .0 3 0 -0 .0 7 4 0 .2 6 6 0 .7 7 9 -0 .0 1 2 0 .0 2 2 0 .0 2 0 0 .2 7 3 0 .0 5 0

B R IE F P a re n t R a tin g : M e ta c o g n itio n (lo w e r = b e tte r) S * -0 .2 6 1 0 .1 3 9 0 .0 6 1 -0 .0 8 1 -1 .0 0 6 1 .6 9 0 0 .5 5 2 -0 .0 2 5 -0 .0 5 8 0 .1 2 7 0 .6 4 9 -0 .0 2 1

B R IE F T e a c h e r R a tin g : M e ta c o g n itio n (lo w e r = b e tte r) 0 .0 2 0 0 .1 8 5 0 .9 1 3 0 .0 0 5 S -2 .9 8 4 2 .3 9 8 0 .2 1 4 -0 .0 6 0 -0 .1 3 2 0 .1 8 2 0 .4 6 8 -0 .0 3 9

B e h a v io r R e g u la tio n (lo w e r = b e tte r)

C R S -R : P a re n t R a tin g : H y p e ra c tiv e /Im p u ls iv e -0 .0 3 7 0 .0 3 9 0 .3 5 0 -0 .0 4 0 0 .0 8 8 0 .4 7 8 0 .8 5 4 0 .0 0 8 -0 .0 0 1 0 .0 3 6 0 .9 7 7 -0 .0 0 1

C R S -R : T e a c h e r R a tin g : H y p e ra c tiv e /Im p u ls iv e 0 .0 2 9 0 .0 4 7 0 .5 3 4 0 .0 2 9 -0 .5 0 9 0 .6 1 6 0 .4 1 0 -0 .0 4 0 -0 .0 4 5 0 .0 4 7 0 .3 3 0 -0 .0 5 2

C R S -R : P a re n t R a tin g : In a tte n tiv e S * -0 .0 7 5 0 .0 4 5 0 .0 9 8 -0 .0 7 2 -0 .1 7 2 0 .5 5 3 0 .7 5 5 -0 .0 1 3 -0 .0 1 6 0 .0 4 2 0 .7 0 8 -0 .0 1 7

C R S -R : T e a c h e r R a tin g : In a tte n tiv e 0 .0 2 1 0 .0 6 0 0 .7 2 7 0 .0 1 6 S * -1 .1 5 1 0 .7 8 7 0 .1 4 4 -0 .0 7 2 -0 .0 5 2 0 .0 5 9 0 .3 8 0 -0 .0 4 7

B R IE F P a re n t R a tin g : B e h a v io r R e g u la tio n -0 .1 1 1 0 .0 8 4 0 .1 8 6 -0 .0 5 8 -0 .9 0 2 1 .0 2 1 0 .3 7 7 -0 .0 3 8 0 .0 1 9 0 .0 7 7 0 .8 0 7 0 .0 1 2

B R IE F T e a c h e r R a tin g : B e h a v io r R e g u la tio n 0 .0 5 8 0 .1 0 0 0 .5 5 8 0 .0 2 7 -0 .2 1 6 1 .2 9 2 0 .8 6 7 -0 .0 0 8 -0 .0 9 1 0 .0 9 9 0 .3 5 9 -0 .0 5 0

T ic s (lo w e r = b e tte r)

M o to r tic s (c u rre n t): A s s e s s o r R a tin g 0 .0 4 4 0 .0 3 0 0 .1 3 4 1 .6 4 8 -0 .5 2 5 0 .4 0 9 0 .2 0 0 0 .6 1 9 0 .0 1 9 0 .0 3 1 0 .5 5 3 1 .2 8 1

P h o n ic s tic s (c u rre n t): A s s e s s o r R a tin g -0 .0 2 8 0 .0 5 0 0 .5 7 2 0 .7 2 5 -0 .2 9 2 0 .4 3 3 0 .5 0 1 0 .7 6 6 0 .0 0 4 0 .0 3 4 0 .9 0 6 1 .0 5 5

M o to r tic s (c u rre n t): P a re n t R a tin g -0 .0 5 5 0 .0 5 6 0 .3 2 8 0 .5 4 0 -0 .8 2 8 0 .3 9 9 0 .0 3 8 + 0 .4 6 9 0 .0 1 4 0 .0 3 2 0 .6 6 5 1 .2 0 4

P h o n ic s tic s (c u rre n t): P a re n t R a tin g -0 .0 7 4 0 .0 5 2 0 .1 5 7 0 .4 3 3 0 .0 9 7 0 .3 8 6 0 .8 0 2 1 .0 9 3 S * -0 .0 4 2 0 .0 2 8 0 .1 2 5 0 .5 6 8

G e n e r a l In te lle c tu a l F u n c tio n in g

W A S I V e rb a l IQ 0 .0 6 0 0 .0 9 9 0 .5 4 2 0 .0 2 3 S * -3 .4 9 6 1 .2 0 2 0 .0 0 4 * -0 .1 0 9 -0 .0 3 8 0 .0 9 1 0 .6 7 3 -0 .0 1 8

W A S I P e rfo rm a n c e IQ 0 .0 2 5 0 .1 1 6 0 .8 2 7 0 .0 0 9 S * -1 .3 1 5 1 .3 6 4 0 .3 3 5 -0 .0 3 9 0 .1 4 1 0 .1 0 2 0 .1 7 0 0 .0 6 1

W A S I F u ll S c a le IQ 0 .0 4 1 0 .1 0 3 0 .6 8 9 0 .0 1 6 S * -2 .7 0 2 1 .2 2 4 0 .0 2 8 * -0 .0 8 5 0 .0 9 6 0 .0 9 3 0 .3 0 5 0 .0 4 4

< .0 5 > .0 5 , < .1 0 < .0 5 > .0 5 , < .1 0

K e y: M e rc u ry e ffe c t = B e tte r O u tc o m e p -v a lu e + p -v a lu e M e rc u ry e ffe c t = W o rs e O u tc o m e p -v a lu e * p -v a lu e

S * (S ) = C o e ffic ie n t fo r fe m a le s is s ig n ific a n tly d iffe re n t th a n c o e ffic ie n t fo r m a le s a t th e 0 .0 5 (0 .1 0 ) le v e l

P -v a lu e s s h o w n a re ro u n d e d to 3 d e c im a l p la c e s . T h e re fo re , a v a lu e s h o w n a s 0 .0 5 0 m a y s a tis ify p < 0 .0 5 c rite rio n if th e o rig in a l v a lu e w a s ro u n d e d u p , o r m a y n o t s a tis ify th e c rite rio n if

th e v a lu e w a s ro u n d e d d o w n .

T e s t

P N _ T ru n c H e p B Y N E x p 1 7 m o s
Abt Associates, Inc. Appendix C 95

Exhibit B.44. Summary of Thimerosal Effects when PreNatThimer is Truncated and HepB Coded as Yes/no – Males

E s t S .E . P S t C f E s t S .E . P S t C f E s t S .E . P S t C f

S p e e c h a n d L a n g u a g e

B o s to n N a m in g T e s t 0 .0 5 9 0 .0 4 4 0 .1 8 7 0 .0 4 1 0 .1 6 6 0 .5 7 5 0 .7 7 3 0 .0 0 9 0 .0 3 8 0 .0 4 3 0 .3 8 0 0 .0 3 1

N E P S Y : S p e e d e d N a m in g 0 .1 2 5 0 .0 5 6 0 .0 2 5 + 0 .0 8 7 - 0 .2 6 5 0 .7 2 1 0 .7 1 3 - 0 .0 1 5 0 .0 0 1 0 .0 5 4 0 .9 8 8 0 .0 0 1

N E P S Y : C o m p r e h e n s io n o f In s tr u c tio n s - 0 .0 0 4 0 .0 2 0 0 .8 2 4 - 0 .0 0 9 S * 0 .2 2 6 0 .2 5 6 0 .3 7 9 0 .0 3 7 - 0 .0 3 0 0 .0 1 9 0 .1 2 5 - 0 .0 7 0

C E L F : F o r m u la te d S e n te n c e s 0 .0 0 6 0 .0 4 3 0 .8 8 8 0 .0 0 5 0 .1 7 2 0 .5 6 3 0 .7 6 0 0 .0 1 2 - 0 .0 2 9 0 .0 4 2 0 .4 9 1 - 0 .0 2 9

C E L F : R e c a llin g S e n te n c e s 0 .0 7 7 0 .0 9 2 0 .4 0 1 0 .0 3 0 - 0 .4 4 0 1 .1 8 2 0 .7 1 0 - 0 .0 1 4 - 0 .0 1 2 0 .0 8 8 0 .8 9 4 - 0 .0 0 5

G F T A : A r tic u la tio n ( lo w e r = b e tte r ) - 0 .0 1 1 0 .0 1 4 0 .4 3 6 - 0 .0 3 3 0 .2 7 7 0 .1 8 0 0 .1 2 3 0 .0 6 7 0 .0 0 7 0 .0 1 3 0 .5 9 6 0 .0 2 5

S tu tte r in g : A s s e s s o r R a tin g ( lo w e r = b e tte r ) - 0 .5 2 8 1 .6 2 4 0 .7 4 5 0 .0 0 3 0 .6 1 8 0 .6 2 0 0 .3 1 9 1 .7 6 0 0 .0 1 4 0 .0 4 4 0 .7 4 4 1 .2 1 1

S tu tte r in g : P a r e n t R a tin g ( lo w e r = b e tte r ) - 0 .0 0 1 0 .0 5 2 0 .9 9 2 0 .9 9 4 - 0 .2 0 6 0 .6 4 9 0 .7 5 1 0 .8 2 8 0 .0 2 0 0 .0 5 6 0 .7 1 4 1 .3 1 1

S tu tte r in g : T e a c h e r R a tin g ( lo w e r = b e tte r ) - 0 .0 4 4 0 .0 4 1 0 .2 8 0 0 .6 0 5 S 0 .8 1 4 0 .4 5 9 0 .0 7 6 2 .1 0 6 0 .0 0 2 0 .0 3 3 0 .9 5 9 1 .0 2 3

V e r b a l M e m o r y

C V L T - C : F r e e R e c a ll, N o D e la y 0 .0 4 9 0 .0 6 8 0 .4 6 9 0 .0 2 9 S 1 .4 0 9 0 .8 7 3 0 .1 0 7 0 .0 6 6 - 0 .0 2 9 0 .0 6 6 0 .6 5 8 - 0 .0 2 0

C V L T - C : F r e e R e c a ll, S h o r t D e la y 0 .0 0 7 0 .0 1 9 0 .7 0 3 0 .0 1 5 S * 0 .3 5 5 0 .2 4 8 0 .1 5 2 0 .0 5 9 - 0 .0 2 9 0 .0 1 8 0 .1 1 5 - 0 .0 7 1

C V L T - C : C u e d R e c a ll, S h o r t D e la y 0 .0 0 9 0 .0 1 7 0 .5 8 7 0 .0 2 1 S * 0 .5 2 4 0 .2 1 4 0 .0 1 5 + 0 .1 0 0 - 0 .0 1 5 0 .0 1 6 0 .3 5 8 - 0 .0 4 1

C V L T - C : F r e e R e c a ll, L o n g D e la y 0 .0 1 4 0 .0 1 8 0 .4 2 7 0 .0 3 1 S * 0 .2 8 2 0 .2 2 9 0 .2 1 9 0 .0 5 1 - 0 .0 3 1 0 .0 1 7 0 .0 7 0 - 0 .0 8 1

C V L T - C : C u e d R e c a ll, L o n g D e la y 0 .0 2 1 0 .0 1 7 0 .2 2 9 0 .0 4 8 S * 0 .5 0 0 0 .2 2 4 0 .0 2 6 + 0 .0 9 2 - 0 .0 0 8 0 .0 1 7 0 .6 5 1 - 0 .0 2 1

C M S S to r ie s 1 : Im m e d ia te R e c a ll 0 .1 2 2 0 .0 8 6 0 .1 5 8 0 .0 4 4 - 0 .2 1 9 1 .1 2 4 0 .8 4 5 - 0 .0 0 6 - 0 .0 9 4 0 .0 8 4 0 .2 6 4 - 0 .0 4 0

C M S S to r ie s 2 : D e la y e d R e c a ll 0 .0 4 9 0 .0 8 5 0 .5 6 6 0 .0 1 8 0 .1 5 9 1 .1 0 8 0 .8 8 6 0 .0 0 5 - 0 .0 4 3 0 .0 8 3 0 .6 0 2 - 0 .0 1 9

A c h ie v e m e n t

W J III: L e tte r - W o r d Id e n tific a tio n 0 .0 6 5 0 .0 5 4 0 .2 3 1 0 .0 3 9 0 .1 0 5 0 .6 9 8 0 .8 8 0 0 .0 0 5 0 .1 2 2 0 .0 5 2 0 .0 1 9 * 0 .0 8 7

F in e M o t o r C o o r d in a t io n

G r o o v e d P e g b o a r d : D o m in a n t H a n d ( lo w e r = b e tte r ) - 0 .1 6 1 0 .1 3 3 0 .2 2 5 - 0 .0 3 3 - 2 .8 1 6 1 .7 0 6 0 .0 9 9 - 0 .0 4 7 - 0 .0 6 0 0 .1 2 7 0 .6 3 7 - 0 .0 1 5

G r o o v e d P e g b o a r d : N o n - d o m H a n d ( lo w e r = b e tte r ) - 0 .0 9 6 0 .1 6 1 0 .5 5 1 - 0 .0 1 7 - 0 .5 5 8 2 .0 5 9 0 .7 8 6 - 0 .0 0 8 - 0 .2 1 2 0 .1 5 5 0 .1 7 3 - 0 .0 4 5

F in g e r T a p p in g : D o m in a n t H a n d - 0 .0 5 1 0 .0 4 5 0 .2 5 5 - 0 .0 4 2 S * 1 .8 1 6 0 .5 8 3 0 .0 0 2 * 0 .1 2 2 0 .0 1 9 0 .0 4 4 0 .6 6 9 0 .0 1 8

F in g e r T a p p in g : N o n - d o m in a n t H a n d - 0 .0 6 7 0 .0 4 1 0 .1 0 4 - 0 .0 6 0 S * 1 .1 6 9 0 .5 3 0 0 .0 2 8 * 0 .0 8 6 0 .0 1 5 0 .0 4 0 0 .6 9 9 0 .0 1 6

V is u a l S p a t ia l A b ilit y

S ta n fo r d B in e t: C o p y in g S * 0 .0 6 4 0 .0 2 2 0 .0 0 4 + 0 .1 2 2 0 .0 3 7 0 .2 8 4 0 .8 9 7 0 .0 0 6 S - 0 .0 1 8 0 .0 2 1 0 .4 0 6 - 0 .0 4 0

A t t e n t io n /E x e c u t iv e F u n c t io n in g

G D S V ig ila n c e T a s k : C o r r e c t R e s p o n s e s 0 .0 0 5 0 .0 3 8 0 .8 8 5 0 .0 0 6 0 .3 1 6 0 .4 8 5 0 .5 1 4 0 .0 2 8 0 .0 2 0 0 .0 3 7 0 .5 8 9 0 .0 2 6

G D S V ig ila n c e T a s k : E r r o r s ( lo w e r = b e tte r ) 0 .0 6 1 0 .0 9 8 0 .5 3 6 0 .0 2 6 0 .1 1 0 1 .2 5 0 0 .9 3 0 0 .0 0 4 0 .0 7 4 0 .0 9 4 0 .4 3 3 0 .0 3 7

W IS C III: D ig it S p a n , F o r w a r d R e c a ll 0 .0 1 3 0 .0 1 4 0 .3 4 2 0 .0 4 0 - 0 .1 4 9 0 .1 8 0 0 .4 1 0 - 0 .0 3 6 0 .0 0 3 0 .0 1 4 0 .7 9 9 0 .0 1 2

W IS C III: D ig it S p a n , B a c k w a r d R e c a ll - 0 .0 2 5 0 .0 1 2 0 .0 3 9 * - 0 .0 8 6 0 .3 3 8 0 .1 5 6 0 .0 3 1 + 0 .0 9 4 0 .0 0 5 0 .0 1 2 0 .6 9 9 0 .0 1 8

W IS C III: D ig it S p a n , C o m b in e d - 0 .0 1 2 0 .0 2 1 0 .5 6 1 - 0 .0 2 4 0 .1 6 3 0 .2 7 7 0 .5 5 5 0 .0 2 5 0 .0 1 1 0 .0 2 1 0 .5 8 4 0 .0 2 6

B R IE F P a r e n t R a tin g : M e ta c o g n itio n ( lo w e r = b e tte r ) S * 0 .1 7 2 0 .1 3 6 0 .2 0 7 0 .0 5 3 1 .6 4 1 1 .7 4 3 0 .3 4 7 0 .0 4 1 - 0 .0 7 8 0 .1 3 0 0 .5 4 9 - 0 .0 2 9

B R IE F T e a c h e r R a tin g : M e ta c o g n itio n ( lo w e r = b e tte r ) 0 .0 2 1 0 .2 0 0 0 .9 1 6 0 .0 0 5 S 3 .6 9 1 2 .4 9 2 0 .1 3 9 0 .0 7 5 - 0 .2 3 8 0 .1 8 7 0 .2 0 3 - 0 .0 7 0

B e h a v io r R e g u la t io n ( lo w e r = b e t t e r )

C R S - R : P a r e n t R a tin g : H y p e r a c tiv e /Im p u ls iv e 0 .0 3 2 0 .0 3 8 0 .4 0 6 0 .0 3 5 0 .8 4 8 0 .4 9 3 0 .0 8 5 0 .0 7 6 0 .0 2 1 0 .0 3 7 0 .5 6 0 0 .0 2 8

C R S - R : T e a c h e r R a tin g : H y p e r a c tiv e /Im p u ls iv e - 0 .0 0 1 0 .0 5 0 0 .9 8 5 - 0 .0 0 1 0 .6 9 4 0 .6 3 3 0 .2 7 3 0 .0 5 5 - 0 .0 6 3 0 .0 4 8 0 .1 8 7 - 0 .0 7 3

C R S - R : P a r e n t R a tin g : In a tte n tiv e S * 0 .0 7 6 0 .0 4 5 0 .0 8 9 0 .0 7 2 0 .7 8 2 0 .5 6 8 0 .1 6 9 0 .0 6 0 - 0 .0 5 0 0 .0 4 3 0 .2 4 5 - 0 .0 5 6

C R S - R : T e a c h e r R a tin g : In a tte n tiv e - 0 .0 0 8 0 .0 6 5 0 .8 9 6 - 0 .0 0 6 S * 1 .4 4 3 0 .8 0 9 0 .0 7 5 0 .0 9 0 - 0 .0 4 2 0 .0 6 2 0 .4 9 7 - 0 .0 3 8

B R IE F P a r e n t R a tin g : B e h a v io r R e g u la tio n 0 .0 1 9 0 .0 8 2 0 .8 1 5 0 .0 1 0 0 .5 7 9 1 .0 4 9 0 .5 8 1 0 .0 2 4 0 .1 5 8 0 .0 7 8 0 .0 4 4 * 0 .0 9 6

B R IE F T e a c h e r R a tin g : B e h a v io r R e g u la tio n 0 .0 0 4 0 .1 0 8 0 .9 7 3 0 .0 0 2 1 .9 2 7 1 .3 4 7 0 .1 5 3 0 .0 7 3 - 0 .0 6 2 0 .1 0 1 0 .5 4 3 - 0 .0 3 4

T ic s ( lo w e r = b e t t e r )

M o to r tic s ( c u r r e n t) : A s s e s s o r R a tin g 0 .0 2 3 0 .0 2 3 0 .3 3 3 1 .2 9 3 0 .2 3 6 0 .3 5 9 0 .5 1 1 1 .2 4 1 0 .0 5 4 0 .0 2 9 0 .0 6 2 2 .0 4 5

P h o n ic s tic s ( c u r r e n t) : A s s e s s o r R a tin g 0 .0 0 4 0 .0 2 7 0 .8 7 0 1 .0 5 1 0 .3 1 0 0 .3 8 7 0 .4 2 3 1 .3 2 8 0 .0 5 7 0 .0 2 9 0 .0 5 1 2 .1 4 7

M o to r tic s ( c u r r e n t) : P a r e n t R a tin g 0 .0 1 4 0 .0 2 3 0 .5 3 8 1 .1 7 8 - 0 .1 9 9 0 .3 3 9 0 .5 5 7 0 .8 3 3 0 .0 0 7 0 .0 2 6 0 .7 8 8 1 .0 9 9

P h o n ic s tic s ( c u r r e n t) : P a r e n t R a tin g 0 .0 1 4 0 .0 2 3 0 .5 4 8 1 .1 6 8 0 .2 0 4 0 .3 4 8 0 .5 5 8 1 .2 0 5 S * 0 .0 4 1 0 .0 2 6 0 .1 0 7 1 .7 3 5

G e n e r a l In t e lle c t u a l F u n c t io n in g

W A S I V e r b a l IQ 0 .0 9 1 0 .0 9 6 0 .3 4 3 0 .0 3 5 S * - 0 .1 1 9 1 .2 4 0 0 .9 2 3 - 0 .0 0 4 0 .0 1 4 0 .0 9 3 0 .8 8 2 0 .0 0 6

W A S I P e r fo r m a n c e IQ - 0 .0 1 2 0 .1 0 9 0 .9 1 4 - 0 .0 0 4 S * 4 .3 1 4 1 .4 0 8 0 .0 0 2 + 0 .1 2 9 0 .0 5 3 0 .1 0 5 0 .6 1 4 0 .0 2 3

W A S I F u ll S c a le IQ 0 .0 5 5 0 .0 9 8 0 .5 7 8 0 .0 2 1 S * 2 .3 0 1 1 .2 5 9 0 .0 6 8 0 .0 7 2 0 .0 3 2 0 .0 9 5 0 .7 3 6 0 .0 1 5

< .0 5 > .0 5 , < .1 0 < .0 5 > .0 5 , < .1 0

K e y : M e r c u r y e ffe c t = B e tte r O u tc o m e p - v a lu e + p - v a lu e M e r c u r y e ffe c t = W o r s e O u tc o m e p - v a lu e * p - v a lu e

S * ( S ) = C o e ffic ie n t fo r m a le s is s ig n ific a n tly d iffe r e n t th a n c o e ffic ie n t fo r fe m a le s a t th e 0 .0 5 ( 0 .1 0 ) le v e l

P - v a lu e s s h o w n a r e r o u n d e d to 3 d e c im a l p la c e s . T h e r e fo r e , a v a lu e s h o w n a s 0 .0 5 0 m a y s a tis ify p < 0 .0 5 c r ite r io n if th e o r ig in a l v a lu e w a s r o u n d e d u p , o r m a y n o t s a tis ify th e c r ite r io n

if th e v a lu e w a s r o u n d e d d o w n .

P N _ T r u n c H e p B Y N E x p 1 7 m o s

T e s t
Abt Associates, Inc. Appendix D 96

4. Appendix D. Change in Estimate and Precision as

Covariates Are Dropped

The graphs in this appendix show the effects of dropping covariates on the estimates of

prenatal exposure effects, cumulative birth to seven months exposure effects8, and

neonatal (birth to one month) exposure effects9. The graphs show how the estimate and

95 percent confidence intervals for each estimated exposure effect change as each

covariate is dropped from the model. The graphs corresponding to each outcome measure

are shown in the same order of appearance as they appear in each of the exhibits in

Section 9. Each graph is read from left to right as in the following example.

The top panel of Exhibit D.4.1.1 shows the extent to which the estimate and 95 percent

confidence interval for PreNatThimer changed as each covariate was dropped from

sequential models. The first model fitted to this outcome included all covariates. (See

Exhibit 7.4.1 of Volume I of the Technical Report for descriptions of all covariates.) The

covariate with the largest p-value, was identified. If the p-value was greater than 0.20 the

variable was dropped from the subsequent model. In this example, it was the indicator

variable for whether the child’s mother had ever had a diagnosis of attention deficit

hyperactivity disorder (MatADHD). If dropping the variable resulted in a change in the

parameter estimates of either PreNatThimer or Exp07mos (cumulative exposure birth to 7

months) that was more than 10 percent, relative to the estimates from the full model, then

the covariate was retained in subsequent models. Otherwise, it was dropped from the

subsequent models10. In this example, the MatADHD variable did not satisfy either the pvalue criterion or the change in estimate criterion, and was therefore dropped.

The symbol at the far left of the graph shows the parameter estimate and 95 percent

confidence interval for PreNatThimer from a model in which MatADHD had been

dropped, but all other covariates remained. The symbol one space to the right shows the

estimate and confidence interval after the ADHD stimulant variable (ADHDStimulant)

had been dropped11. Moving left to right shows the estimate and 95 percent confidence

interval as each successive covariate is dropped. The vertical dotted line indicates the

break between the dropped variables and the variables that were included in the final

model. In this example, the ChildMedHist_1 variable, and all the covariates shown to the

right of ChildMedHist_1 were retained in the final model. Moving from left to right from

this point shows what would have happened to the estimate for PreNatThimer if those

variables had not been included as covariates.

The variable Site (coded as three dummies representing the four HMOs) and all variables

shown to the right of the Site variable (except computer experience) were included in all

models. These were the a priori selected variables, as described in Section 8. It is

8 These results are from the main effect model for PreNatThimer and Exp07mos exposures. See Model (1)

specified in Section 9.2.2.2 for details.

9 These results are from the main effect model for PreNatThimer, HepB, and Exp17mos exposures. See

Model (2) specified in Section 9.2.2.2 for details.

10 For additional information on the decision rules, see Section 8.2 of Volume I of the Technical Report.

11 For descriptions of all covariates, see Exhibit 7.4.1, in Volume I of the Technical Report.
Abt Associates, Inc. Appendix D 97

interesting to note that the inclusion or omission of any of the variables to the left of Site

did not have dramatic effect on the estimate or the precision of the estimate of the

PreNatThimer effect. Looking across the graphs of all 42 outcome variables, this

generally held true. The inclusion or exclusion of the variables that were tested for

inclusion in the models tended to not have dramatic effects on the estimates. Exclusion of

the Site variable, and some of the other a priori selected variables would, however, result

in meaningful differences. The variable that appeared to be especially important was the

measure of maternal IQ (MomIQ). In this example, omission of the MomIQ covariate

would have changed the estimate of the PreNatThimer effect considerably, from barely

significant to clearly significant, with higher exposure being related to better scores on

the Boston Naming Test.

The effects of dropping covariates on the estimates of HepB and Exp07mos effects were

similar to those described for PreNatThimer. In general, inclusion or exclusion of

covariates shown to the left of Site did not have dramatic effects on the estimates or the

precision of HepB and Exp07mos. But inclusion or exclusion of site or those to the right

often did have dramatic effects on the estimates.

The effects of inclusion or exclusion of a covariate on the precision (95 percent

confidence interval) of exposure effects were subtle. It is difficult to distinguish

differences in the widths of the 95 percent confidence intervals from the graphs.

However, it is interesting to note that examination of print-outs of numerical values

indicated that the rules for inclusion/exclusion of covariates generally had the anticipated

effects on precision. That is, when the decision rules indicated a covariate should be

dropped, then in the vast majority of cases, dropping the variable resulted in a small

increase in precision of the exposure estimate. Likewise, when the decision rules

indicated a covariate should be retained, then in the vast majority of cases, dropping the

variable resulted in a small decrease in the precision of the exposure estimate.

We note that we were not able to fit models to the tics and stuttering outcomes that

simultaneously included the entire list of covariates. These outcomes were fit to logistic

regression models, and we encountered problems with quasi-separation due to zero

counts in some cells defined by the covariates. In those models a mix of forward and

backward selection strategies, in concert with the change-in-estimate criteria and a priori

selection criteria, resulted in evaluation of all covariates for inclusion.
Abt Associates, Inc. Appendix D 98

4.1. PreNatThimer

List of Exhibits Page

Speech and Language

Exhibit D.4.1.1. Boston Naming Test 99

Exhibit D.4.1.2. NEPSY: Speeded Naming 99

Exhibit D.4.1.3. NEPSY: Comprehension of Instructions 100

Exhibit D.4.1.4. CELF: Formulated Sentences 100

Exhibit D.4.1.5. CELF: Recalling Sentences 101

Exhibit D.4.1.6. GFTA: Articulation (lower = better) 101

Exhibit D.4.1.7. Stuttering: Assessor Rating (lower = better) 102

Exhibit D.4.1.8. Stuttering: Parent Rating (lower = better) 102

Exhibit D.4.1.9. Stuttering: Teacher Rating (lower = better) 103

Verbal Memory

Exhibit D.4.1.10. CVLT-C: Free Recall, No Delay 103

Exhibit D.4.1.11. CVLT-C: Free Recall, Short Delay 104

Exhibit D.4.1.12. CVLT-C: Cued Recall, Short Delay 104

Exhibit D.4.1.13. CVLT-C: Free Recall, Long Delay 105

Exhibit D.4.1.14. CVLT-C: Cued Recall, Long Delay 105

Exhibit D.4.1.15. CMS Stories 1: Immediate Recall 106

Exhibit D.4.1.16. CMS Stories 2: Delayed Recall 106

Achievement

Exhibit D.4.1.17. WJIII: Letter- Word Identification 107

Fine Motor Coordination

Exhibit D.4.1.18. Grooved Pegboard: Dominant Hand (lower = better) 107

Exhibit D.4.1.19. Grooved Pegboard: Non-dom Hand (lower = better) 108

Exhibit D.4.1.20. Finger Tapping: Dominant Hand 108

Exhibit D.4.1.21. Finger Tapping: Non-dominant Hand 109

Visual Spatial Ability

Exhibit D.4.1.22. Stanford Binet: Copying 109

Attention/ Executive Functioning

Exhibit D.4.1.23. GDS Vigilance Task: Correct Responses 110

Exhibit D.4.1.24. GDS Vigilance Task: Errors (lower = better) 110

Exhibit D.4.1.25. WISC III: Digit Span, Forward Recall 111

Exhibit D.4.1.26. WISC III: Digit Span, Backward Recall 111

Exhibit D.4.1.27. WISC III: Digit Span, Combined 112

Exhibit D.4.1.28. BRIEF Parent Rating: Metacognition (lower = better) 112

Exhibit D.4.1.29. BRIEF Teacher Rating: Metacognition (lower = better) 113

Behavior Regulation (lower = better)

Exhibit D.4.1.29. BRIEF Teacher Rating: Metacognition (lower = better) 113

Exhibit D.4.1.31. CRS-R: Teacher Rating: Hyperactive/Impulsive (lower = 114

Exhibit D.4.1.32. CRS-R: Parent Rating: Inattentive (lower = better) 114

Exhibit D.4.1.33. CRS-R: Teacher Rating: Inattentive (lower = better) 115

Exhibit D.4.1.34. BRIEF Parent Rating: Behavior Regulation (lower = better) 115

Exhibit D.4.1.35. BRIEF Teacher Rating: Behavior Regulation (lower = 116

Tics (lower = better)

Exhibit D.4.1.36. Motor tics (current): Assessor Rating (lower = better) 116

Exhibit D.4.1.37. Phonics tics (current): Assessor Rating (lower = better) 117

Exhibit D.4.1.38. Motor tics (current): Parent Rating (lower = better) 117

Exhibit D.4.1.39. Phonics tics (current): Parent Rating (lower = better) 118

General Intellectual Functioning

Exhibit D.4.1.40. WASI Verbal IQ 118

Exhibit D.4.1.41. WASI Performance IQ 119

Exhibit D.4.1.42. WASI Full Scale IQ 119
Abt Associates, Inc. Appendix D 99

Exhibit D.4.1.1. Boston Naming Test

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

Boston Naming Test

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30

-0.10 -0.05 0.0 0.05 0.10 0.15

MatADHDADHDstimulantPreNatNicotine_1ChdPICA_1PreNatAlcohol_1ChildAge3PctPoverty1_3PctPoverty1_2DayCareHomeImpVal1DayCareCentrImpVal1PreNatHomePro_1PreNatTuna_1ChildAge2MatLangDelChildMedHist_1EngOnlyPreNatFish_1MatAgeCatMatSTUTTERPreNatFillings_1PreNatlead_1MatSpeechDelYoungerSibsOlderSibsBFMthsCatSiteSingleParentsexmaleMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprChdBWT_CatChildAge

Final model at dotted line

Exhibit D.4.1.2. NEPSY Speeded Naming

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

NEPSY: Speeded Naming

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.1 0.0 0.1 0.2

MatSTUTTERDayCareCentrImpVal1C5APGARImpVal1ChdPICA_1PctPoverty1_3PctPoverty1_2EngOnlyADHDstimulantPreNatAlcohol_1PreNatIllDrugChildAge3MatSpeechDelChildAge2PreNatFillings_1YoungerSibsMatAgeCatPreNatlead_1IronDef_1PreNatNicotine_1PreNatHomePro_1ChildMedHist_1PreNatOrgMerc_1ComputerExprPreNatFish_1PreNatTuna_1MatADHDDayCareHomeImpVal1BFMthsCatOlderSibsMatLangDelSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 100

Exhibit D.4.1.3. NEPSY Comprehension of Instructions

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

NEPSY: Comprehension of Instructions

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30

-0.10 -0.05 0.0 0.05 0.10

PctPoverty1_3ChdPICA_1MatSpeechDelEngOnlyPctPoverty1_2MatAgeCatYoungerSibsMatSTUTTERADHDstimulantPreNatOrgMerc_1PreNatlead_1DayCareHomeImpVal1DayCareCentrImpVal1PreNatFillings_1PreNatHomePro_1PreNatTuna_1ChildAge3ChildAge2MatADHDMatLangDelIronDef_1C5APGARImpVal1PreNatIllDrugPreNatFish_1PreNatAlcohol_1PreNatNicotine_1BFMthsCatOlderSibsSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.1.4. CELF Formulated Sentences

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

CELF: Formulated Sentences

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.1 0.0 0.1 0.2

MatSpeechDelDayCareHomeImpVal1PreNatFillings_1PreNatTuna_1PreNatIllDrugPreNatFish_1MatAgeCatPreNatlead_1PreNatOrgMerc_1PreNatHomePro_1PreNatNicotine_1MatADHDChdPICA_1PreNatAlcohol_1C5APGARImpVal1YoungerSibsADHDstimulantChildMedHist_1EngOnlyPctPoverty1_3MatSTUTTERChdBWT_GrpPctPoverty1_2DayCareCentrImpVal1IronDef_1ChildAge3ChildAge2OlderSibsMatLangDelBFMthsCatSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 101

Exhibit D.4.1.5. CELF Recalling Sentences

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

CELF: Recalling Sentences

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.2 -0.1 0.0 0.1 0.2 0.3

YoungerSibsPreNatIllDrugPreNatHomePro_1ChildMedHist_1PreNatNicotine_1DayCareHomeImpVal1PctPoverty1_3PreNatTuna_1PreNatFillings_1PctPoverty1_2ADHDstimulantMatAgeCatMatLangDelChdPICA_1ComputerExprPreNatOrgMerc_1DayCareCentrImpVal1ChildAge3ChildAge2MatADHDMatSTUTTERMatSpeechDelIronDef_1C5APGARImpVal1PreNatlead_1PreNatFish_1PreNatAlcohol_1BFMthsCatEngOnlyOlderSibsSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.1.6. GFTA Articulation

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

GFTA: Articulation (lower=better)

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.10 -0.05 0.0 0.05 0.10

ADHDstimulantBFMthsCatMatAgeCatEngOnlyYoungerSibsPreNatlead_1PreNatNicotine_1PreNatIllDrugMatSTUTTERPreNatOrgMerc_1ChildAge3ChildAge2PreNatHomePro_1ChildMedHist_1DayCareCentrImpVal1DayCareHomeImpVal1PreNatFillings_1PreNatFish_1PreNatTuna_1ChdPICA_1ComputerExprChdBWT_GrpPctPoverty1_3PctPoverty1_2MatADHDMatSpeechDelMatLangDelIronDef_1C5APGARImpVal1PreNatAlcohol_1OlderSibsSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1sexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 102

Exhibit D.4.1.7. Stuttering Assessor Rating

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

Stuttering: Assessor Rating (lower=better)

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

5 10 15 20

-0.15 -0.10 -0.05 0.0 0.05 0.10 0.15

BFMthsCatMatSpeechDelPreNatOrgMerc_1ChildMedHist_1ChildAge3ChildAge2PctPoverty1_3PctPoverty1_2PreNatAlcohol_1PreNatlead_1MatSTUTTERHOME_TotalIndexMomIQ1SingleParentSiteMomEducsexmalePctPoverty1ChdBWT_GrpChildAge

Final model at dotted line

Exhibit D.4.1.8. Stuttering Parent Rating

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

Stuttering: Parent Rating (lower=better)

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

2 4 6 8

-0.2 -0.1 0.0 0.1 0.2

MomIQ1SingleParentHOME_TotalIndexPctPoverty1sexmaleSiteChdBWT_GrpMomEducChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 103

Exhibit D.4.1.9. Stuttering Teacher Rating

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

Stuttering: Teacher Rating (lower=better)

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 5 10 15 20 25

-0.2 -0.1 0.0 0.1

EngOnlyBFMthsCatPreNatFillings_1PreNatNicotine_1PreNatOrgMerc_1PreNatlead_1IronDefPreNatHomePro_1C5APGARImpVal1DayCareCentrImpVal1ChildAge3ChildAge2ComputerExprPreNatFish_1MatLangDelYoungerSibsPctPoverty1_3PctPoverty1_2PreNatAlcohol_1MomIQ1ChdBWT_GrpSingleParentMomEducPctPoverty1HOME_TotalIndexSitesexmaleChildAge

Final model at dotted line

Exhibit D.4.1.10. CVLT-C: Free Recall, No Delay

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

CVLT-C: Free Recall, No Delay

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.2 -0.1 0.0 0.1 0.2

MatAgeCatPreNatTuna_1MatADHDPctPoverty1_3PctPoverty1_2ADHDstimulantOlderSibsDayCareHomeImpVal1DayCareCentrImpVal1ChildAge3PreNatOrgMerc_1ChildAge2PreNatFish_1IronDef_1YoungerSibsPreNatIllDrugPreNatAlcohol_1MatSpeechDelPreNatNicotine_1PreNatHomePro_1ChdBWT_GrpMatSTUTTERPreNatlead_1EngOnlyPreNatFillings_1ChdPICA_1ChildMedHist_1C5APGARImpVal1BFMthsCatMatLangDelSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 104

Exhibit D.4.1.11. CVLT-C: Free Recall, Short Delay

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

CVLT-C: Free Recall, Short Delay

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.10 -0.05 0.0 0.05 0.10

IronDef_1PreNatFish_1DayCareCentrImpVal1MatAgeCatChildAge3MatSpeechDelMatSTUTTERBFMthsCatMatADHDPctPoverty1_3OlderSibsADHDstimulantPreNatIllDrugC5APGARImpVal1YoungerSibsComputerExprPreNatNicotine_1PreNatHomePro_1PreNatOrgMerc_1PreNatFillings_1ChdPICA_1ChildMedHist_1PreNatTuna_1DayCareHomeImpVal1PreNatAlcohol_1ChdBWT_GrpPctPoverty1_2PreNatlead_1ChildAge2EngOnlyMatLangDelSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1sexmaleChildAge

Final model at dotted line

Exhibit D.4.1.12. CVLT-C: Cued Recall, Short Delay

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

CVLT-C: Cued Recall, Short Delay

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.10 -0.05 0.0 0.05 0.10

PreNatNicotine_1MatAgeCatPreNatFish_1PctPoverty1_3BFMthsCatChildAge3PreNatIllDrugPctPoverty1_2MatSTUTTERDayCareCentrImpVal1MatADHDPreNatlead_1PreNatFillings_1PreNatAlcohol_1ADHDstimulantIronDef_1PreNatTuna_1ChdPICA_1ComputerExprPreNatOrgMerc_1ChildMedHist_1ChildAge2MatSpeechDelMatLangDelC5APGARImpVal1PreNatHomePro_1EngOnlyDayCareHomeImpVal1YoungerSibsOlderSibsSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 105

Exhibit D.4.1.13. CVLT-C: Free Recall, Long Delay

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

CVLT-C: Free Recall, Long Delay

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.10 -0.05 0.0 0.05 0.10

OlderSibsPctPoverty1_3PreNatIllDrugIronDef_1MatAgeCatPreNatFish_1MatADHDMatSpeechDelPreNatAlcohol_1MatSTUTTERPreNatFillings_1ChildAge3PreNatNicotine_1ChdPICA_1ComputerExprPreNatTuna_1BFMthsCatPctPoverty1_2ChildAge2MatLangDelADHDstimulantC5APGARImpVal1PreNatlead_1PreNatHomePro_1PreNatOrgMerc_1EngOnlyDayCareHomeImpVal1DayCareCentrImpVal1YoungerSibsChildMedHist_1SiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.1.14. CVLT-C: Cued Recall, Long Delay

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

CVLT-C: Cued Recall, Long Delay

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.10 -0.05 0.0 0.05 0.10 0.15

ChdPICA_1PctPoverty1_3PctPoverty1_2MatSpeechDelPreNatNicotine_1BFMthsCatOlderSibsChildAge3ChildAge2IronDef_1MatADHDMatSTUTTERPreNatFillings_1MatAgeCatPreNatAlcohol_1C5APGARImpVal1ComputerExprPreNatIllDrugPreNatlead_1PreNatFish_1PreNatTuna_1MatLangDelADHDstimulantPreNatHomePro_1PreNatOrgMerc_1EngOnlyDayCareHomeImpVal1DayCareCentrImpVal1YoungerSibsChildMedHist_1SiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 106

Exhibit D.4.1.15. CMS Stories 1: Immediate Recall

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

CMS Stories 1: Immediate Recall

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30

-0.2 -0.1 0.0 0.1 0.2 0.3

PctPoverty1_3MatADHDADHDstimulantPreNatNicotine_1ChdPICA_1PreNatAlcohol_1PctPoverty1_3PctPoverty1_2PreNatHomePro_1MatSpeechDelEngOnlyPreNatFish_1MatAgeCatPreNatFillings_1ChildMedHist_1YoungerSibsPreNatTuna_1MatSTUTTERC5APGARImpVal1IronDef_1ChildAge3ChildAge2MatLangDelPreNatlead_1BFMthsCatDayCareCentrImpVal1OlderSibsSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.1.16. CMS Stories 2: Delayed Recall

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

CMS Stories 2: Delayed Recall

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.3 -0.2 -0.1 0.0 0.1 0.2 0.3

PreNatHomePro_1ADHDstimulantPreNatNicotine_1MatAgeCatPreNatAlcohol_1PreNatFillings_1MatSpeechDelC5APGARImpVal1ChdPICA_1PreNatTuna_1PreNatIllDrugYoungerSibsComputerExprChildMedHist_1PctPoverty1_3PctPoverty1_2PreNatFish_1MatADHDEngOnlyPreNatOrgMerc_1MatSTUTTERPreNatlead_1ChildAge3ChildAge2MatLangDelIronDef_1BFMthsCatDayCareHomeImpVal1DayCareCentrImpVal1OlderSibsSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 107

Exhibit D.4.1.17. WJIII: Letter- Word Identification

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

WJIII Letter-Word Identification

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.10 -0.05 0.0 0.05 0.10 0.15

PreNatNicotine_1MatAgeCatMatSTUTTERChildMedHist_1DayCareCentrImpVal1PreNatHomePro_1ChdPICA_1IronDef_1C5APGARImpVal1PreNatIllDrugDayCareHomeImpVal1PreNatFillings_1PctPoverty1_3PreNatTuna_1ADHDstimulantMatLangDelChildAge3HOME_TotalIndexsexmalePreNatOrgMerc_1PreNatFish_1PreNatlead_1SingleParentBFMthsCatChdBWT_GrpPreNatAlcohol_1PctPoverty1_2YoungerSibsEngOnlyOlderSibsMatSpeechDelMatADHDChildAge2MomEducPctPoverty1SiteMomIQ1ComputerExprChildAge

Final model at dotted line

Exhibit D.4.1.18. Grooved Pegboard: Dominant Hand (lower = better)

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

Grooved Pegboard: Dominant Hand (lower=better)

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.6 -0.4 -0.2 0.0 0.2

ChildAge2_Spline9ChildAge2ChildAge_Spline9ChildAge2_Spline9YoungerSibsMatAgeCatMatSpeechDelMatSTUTTERADHDstimulantPctPoverty1_3PreNatNicotine_1OlderSibsPctPoverty1_2PreNatlead_1ChdPICA_1PreNatFillings_1DayCareCentrImpVal1PreNatTuna_1PreNatHomePro_1ComputerExprChildMedHist_1PreNatAlcohol_1PreNatOrgMerc_1BFMthsCatMatADHDPreNatFish_1EngOnlyDayCareHomeImpVal1MatLangDelSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleSpline9ChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 108

x

Exhibit D.4.1.19. Grooved Pegboard: Non-dom Hand (lower = better)

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

Grooved Pegboard: Non-dominant Hand (lower=better)

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.6 -0.4 -0.2 0.0 0.2 0.4

PctPoverty1_3PreNatlead_1ChdPICA_1YoungerSibsMatSpeechDelPreNatFish_1ComputerExprIronDef_1MatADHDPreNatAlcohol_1DayCareCentrImpVal1ChildAge2_Spline9MatSTUTTERC5APGARImpVal1OlderSibsPctPoverty1_2MatAgeCatPreNatIllDrugADHDstimulantMatLangDelPreNatFillings_1PreNatHomePro_1PreNatOrgMerc_1PreNatTuna_1PreNatNicotine_1BFMthsCatEngOnlyDayCareHomeImpVal1ChildMedHist_1SiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge2_Spline9ChildAge2ChildAge_Spline9Spline9ChildAge

Final model at dotted line

Exhibit D.4.1.20. Finger Tapping: Dominant Hand

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

Finger Tapping: Dominant Hand

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.2 -0.1 0.0 0.1

MatSpeechDelPreNatFish_1ADHDstimulantPreNatHomePro_1C5APGARImpVal1PreNatNicotine_1PreNatOrgMerc_1ChildAge3PreNatIllDrugMatSTUTTERPreNatAlcohol_1PctPoverty1_3IronDef_1PctPoverty1_2PreNatTuna_1ChdPICA_1DayCareHomeImpVal1PreNatlead_1PreNatFillings_1ChildMedHist_1OlderSibsDayCareCentrImpVal1YoungerSibsMatAgeCatEngOnlyChildAge2BFMthsCatMatLangDelMatADHDMomIQ1ChdBWT_CatSingleParentPctPoverty1SiteMomEducHOME_TotalIndexComputerExprsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 109

Exhibit D.4.1.21. Finger Tapping: Non-dominant Hand

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

Finger Tapping: Non-dominant Hand

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30

-0.2 -0.1 0.0 0.1

C5APGARImpVal1PctPoverty1_3MatSTUTTERDayCareHomeImpVal1PreNatTuna_1ChdPICA_1PreNatNicotine_1IronDef_1PreNatIllDrugMatSpeechDelADHDstimulantPreNatOrgMerc_1ChildMedHist_1PreNatFillings_1EngOnlyOlderSibsChildAge3ChildAge2ChdBWT_GrpPreNatlead_1PreNatHomePro_1PreNatAlcohol_1MatAgeCatPctPoverty1_2YoungerSibsPreNatFish_1DayCareCentrImpVal1MatLangDelMatADHDSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprsexmaleChildAge

Final model at dotted line

Exhibit D.4.1.22. Stanford Binet: Copying

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

Stanford Binet: Copying

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.10 -0.05 0.0 0.05 0.10

BFMthsCatDayCareCentrImpVal1PreNatIllDrugPreNatOrgMerc_1ADHDstimulantYoungerSibsMatSTUTTERPreNatHomePro_1MatADHDPreNatlead_1ChdPICA_1MatSpeechDelChildMedHist_1C5APGARImpVal1PreNatFish_1PreNatTuna_1PreNatNicotine_1ChildAge3ComputerExprOlderSibsDayCareHomeImpVal1MatAgeCatPreNatAlcohol_1PctPoverty1_3PctPoverty1_2ChildAge2MatLangDelIronDef_1PreNatFillings_1EngOnlySiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 110

Exhibit D.4.1.23. GDS Vigilance Task: Correct Responses

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

GDS Vigilance Task: Correct Responses

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.15 -0.10 -0.05 0.0 0.05 0.10

YoungerSibsPreNatFish_1MatADHDEngOnlyPctPoverty1_3DayCareCentrImpVal1ChdBWT_GrpOlderSibsPreNatFillings_1ChdPICA_1MatSTUTTERPreNatAlcohol_1PreNatIllDrugMatAgeCatChildMedHist_1PreNatNicotine_1IronDef_1ADHDstimulantMatLangDelPreNatOrgMerc_1PreNatlead_1PreNatTuna_1DayCareHomeImpVal1ChildAge3ChildAge2PreNatHomePro_1C5APGARImpVal1MatSpeechDelPctPoverty1_2BFMthsCatSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprsexmaleChildAge

Final model at dotted line

Exhibit D.4.1.24. GDS Vigilance Task: Errors (lower=better)

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

GDS Vigilance Task: Errors (lower=better)

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.3 -0.2 -0.1 0.0 0.1 0.2 0.3

PreNatHomePro_1PreNatlead_1PreNatFillings_1EngOnlyPreNatFish_1PreNatIllDrugMatAgeCatChildMedHist_1DayCareCentrImpVal1ChdBWT_GrpChildAge3ChildAge2PctPoverty1_3PctPoverty1_2DayCareHomeImpVal1C5APGARImpVal1PreNatAlcohol_1OlderSibsMatADHDADHDstimulantIronDef_1MatSTUTTERPreNatOrgMerc_1ChdPICA_1PreNatTuna_1YoungerSibsPreNatNicotine_1BFMthsCatMatSpeechDelMatLangDelSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 111

Exhibit D.4.1.25. WISC III: Digit Span, Forward Recall

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

WISC III: Digit Span, Forward Recall

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.04 -0.02 0.0 0.02 0.04

PreNatIllDrugDayCareCentrImpVal1EngOnlyChdPICA_1IronDef_1YoungerSibsDayCareHomeImpVal1PreNatFillings_1MatADHDPreNatTuna_1ChildMedHist_1MatSpeechDelPreNatOrgMerc_1BFMthsCatOlderSibsComputerExprMatAgeCatPreNatHomePro_1PreNatAlcohol_1PctPoverty1_3PctPoverty1_2ChildAge3ChildAge2MatSTUTTERMatLangDelADHDstimulantC5APGARImpVal1PreNatlead_1PreNatFish_1PreNatNicotine_1SiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.1.26. WISC III: Digit Span, Backward Recall

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

WISC III: Digit Span, Backward Recall

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.08 -0.06 -0.04 -0.02 0.0 0.02 0.04

ComputerExprDayCareHomeImpVal1PctPoverty1_3MatAgeCatIronDef_1PreNatNicotine_1PreNatTuna_1C5APGARImpVal1MatSTUTTERPreNatOrgMerc_1PreNatFillings_1DayCareCentrImpVal1PreNatAlcohol_1YoungerSibsMatSpeechDelMatLangDelPreNatHomePro_1DayCareCentrImpVal1ChildMedHist_1ChdPICA_1PreNatFish_1OlderSibsPreNatlead_1ChildAge3ChildAge2EngOnlyADHDstimulantBFMthsCatsexmaleMomEducPctPoverty1HOME_TotalIndexSingleParentSitePreNatIllDrugMatADHDMomIQ1ChdBWT_CatChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 112

Exhibit D.4.1.27. WISC III: Digit Span, Combined

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

WISC III: Digit Span, Combined

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.10 -0.05 0.0 0.05 0.10

PreNatFillings_1PreNatHomePro_1DayCareCentrImpVal1DayCareHomeImpVal1IronDef_1MatAgeCatYoungerSibsChildAge3ChildAge2PreNatTuna_1PreNatNicotine_1ComputerExprChdPICA_1EngOnlyPreNatOrgMerc_1PreNatAlcohol_1MatSpeechDelMatSTUTTERChildMedHist_1PctPoverty1_3PctPoverty1_2OlderSibsMatADHDMatLangDelADHDstimulantC5APGARImpVal1PreNatIllDrugPreNatlead_1PreNatFish_1BFMthsCatSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.1.28. BRIEF Parent Rating: Metacognition (lower = better)

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

BRIEF Parent Rating: Metacognition (lower=better)

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.4 -0.2 0.0 0.2 0.4

PctPoverty1_3IronDef_1YoungerSibsBFMthsCatOlderSibsPreNatIllDrugMatAgeCatMatSTUTTERMatSpeechDelPreNatFish_1PreNatFillings_1PctPoverty1_2ChildMedHist_1ChildAge3ChildAge2PreNatlead_1C5APGARImpVal1PreNatHomePro_1MatADHDMatLangDelChdPICA_1ADHDstimulantPreNatOrgMerc_1PreNatTuna_1PreNatAlcohol_1PreNatNicotine_1EngOnlyDayCareHomeImpVal1DayCareCentrImpVal1SiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprChdBWT_GrpsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 113

Exhibit D.4.1.29. BRIEF Teacher Rating: Metacognition (lower = better)

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

BRIEF Teacher Rating: Metacognition (lower=better)

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.4 -0.2 0.0 0.2 0.4

MatSpeechDelOlderSibsPreNatIllDrugChildAge3PreNatFish_1PctPoverty1_3ChdPICA_1IronDef_1MatLangDelYoungerSibsComputerExprChildMedHist_1MatAgeCatPreNatlead_1PreNatHomePro_1C5APGARImpVal1MatSTUTTERChildAge2DayCareHomeImpVal1PreNatNicotine_1PctPoverty1_2MatADHDADHDstimulantPreNatFillings_1PreNatOrgMerc_1PreNatTuna_1PreNatAlcohol_1BFMthsCatEngOnlyDayCareCentrImpVal1SiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.1.30. CRS-R: Parent Rating: Hyperactive/Impulsive (lower = better)

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

CRS-R: Parent Rating: Hyperactive/Impulsive

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.15 -0.10 -0.05 0.0 0.05 0.10 0.15

MatLangDelChildMedHist_1ChildAge3IronDef_1PreNatFish_1PreNatlead_1ChildAge2PctPoverty1_3MatSpeechDelPreNatIllDrugPreNatFillings_1YoungerSibsC5APGARImpVal1MatSTUTTEREngOnlyPreNatOrgMerc_1PreNatTuna_1ComputerExprMatAgeCatBFMthsCatPreNatAlcohol_1PctPoverty1_2MatADHDChdPICA_1ADHDstimulantPreNatHomePro_1PreNatNicotine_1DayCareHomeImpVal1DayCareCentrImpVal1OlderSibsSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 114

Exhibit D.4.1.31. CRS-R: Teacher Rating: Hyperactive/Impulsive (lower = better)

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

CRS-R: Teacher Rating: Hyperactive/Impulsive

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.15 -0.10 -0.05 0.0 0.05 0.10 0.15

PreNatAlcohol_1ChdPICA_1PreNatFillings_1PreNatHomePro_1PreNatNicotine_1OlderSibsPreNatlead_1MatAgeCatPctPoverty1_3MatSpeechDelMatLangDelMatADHDDayCareHomeImpVal1YoungerSibsMatSTUTTERPreNatFish_1ChildAge3ChildAge2ComputerExprIronDef_1ChildMedHist_1C5APGARImpVal1PctPoverty1_2ADHDstimulantPreNatIllDrugPreNatOrgMerc_1PreNatTuna_1BFMthsCatEngOnlyDayCareCentrImpVal1SiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.1.32. CRS-R: Parent Rating: Inattentive (lower = better)

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

CRS-R: Parent Rating: Inattentive

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.15 -0.10 -0.05 0.0 0.05 0.10 0.15

PreNatHomePro_1MatSTUTTERYoungerSibsPctPoverty1_3PreNatOrgMerc_1BFMthsCatOlderSibsMatSpeechDelMatAgeCatC5APGARImpVal1PreNatlead_1IronDef_1PreNatFillings_1ChildAge3PreNatIllDrugChildMedHist_1ChildAge2EngOnlyDayCareCentrImpVal1MatLangDelPreNatFish_1ChdPICA_1PreNatNicotine_1PreNatAlcohol_1PreNatTuna_1PctPoverty1_2MatADHDDayCareHomeImpVal1ADHDstimulantSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprChdBWT_CatsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 115

Exhibit D.4.1.33. CRS-R: Teacher Rating: Inattentive (lower = better)

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

CRS-R: Teacher Rating: Inattentive

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.2 -0.1 0.0 0.1

OlderSibsPreNatlead_1PreNatIllDrugPctPoverty1_3MatSpeechDelPreNatFish_1YoungerSibsDayCareHomeImpVal1ChdPICA_1C5APGARImpVal1MatSTUTTEREngOnlyPreNatOrgMerc_1PctPoverty1_2ChildAge3ChildAge2MatAgeCatIronDef_1PreNatAlcohol_1PreNatHomePro_1ChildMedHist_1MatLangDelMatADHDBFMthsCatADHDstimulantPreNatNicotine_1PreNatTuna_1PreNatFillings_1DayCareHomeImpVal1SiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.1.34. BRIEF Parent Rating: Behavior Regulation (lower = better)

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

BRIEF Parent Rating: Behavior Regulation

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.3 -0.2 -0.1 0.0 0.1 0.2

MatLangDelC5APGARImpVal1MatSTUTTERMatSpeechDelPreNatIllDrugIronDef_1PctPoverty1_3PreNatOrgMerc_1PreNatlead_1MatAgeCatChildAge3YoungerSibsBFMthsCatChildAge2PreNatFish_1PreNatFillings_1ComputerExprEngOnlyPreNatAlcohol_1ChdBWT_GrpChildMedHist_1PreNatTuna_1OlderSibsPreNatHomePro_1DayCareHomeImpVal1PreNatNicotine_1ChdPICA_1PctPoverty1_2DayCareCentrImpVal1ADHDstimulantMatADHDSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1sexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 116

Exhibit D.4.1.35. BRIEF Teacher Rating: Behavior Regulation (lower = better)

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

BRIEF Teacher Rating: Behavior Regulation

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.2 0.0 0.2

PreNatFillings_1MatLangDelMatAgeCatChildAge3PreNatIllDrugPreNatFish_1PreNatTuna_1IronDef_1MatSpeechDelComputerExprChdPICA_1PreNatOrgMerc_1PreNatHomePro_1MatSTUTTERDayCareHomeImpVal1PreNatNicotine_1ChildAge2C5APGARImpVal1BFMthsCatPreNatAlcohol_1PctPoverty1_3PctPoverty1_2MatADHDADHDstimulantPreNatlead_1EngOnlyDayCareCentrImpVal1YoungerSibsOlderSibsChildMedHist_1SiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.1.36. Motor tics (current): Assessor Rating (lower = better)

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

Motor tics (current): Assessor Rating

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

5 10 15 20 25

-0.10 -0.05 0.0 0.05 0.10

EngOnlyPreNatHomePro_1DayCareCentrImpVal1PctPoverty1_3PctPoverty1_2DayCareHomeImpVal1MatSTUTTERC5APGARImpVal1PreNatAlcohol_1IronDefPreNatTuna_1PreNatFish_1BFMthsCatChildMedHist_1ChildAge3ChildAge2ComputerExprHOME_TotalIndexSingleParentMomEducChdBWT_GrpMomIQ1PctPoverty1SiteChildAgesexmale

Final model at dotted line
Abt Associates, Inc. Appendix D 117

Exhibit D.4.1.37. Phonics tics (current): Assessor Rating (lower = better)

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

Phonics tics (current): Assessor Rating

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

5 10 15 20

-0.15 -0.10 -0.05 0.0 0.05 0.10

IronDefChildAge3BFMthsCatC5APGARImpVal1DayCareCentrImpVal1ChildAge2ComputerExprChdPICA_1PreNatAlcohol_1PreNatHomePro_1PctPoverty1_3PctPoverty1_2PreNatTuna_1PreNatFish_1DayCareHomeImpVal1ChdBWT_GrpMomIQ1MomEducPctPoverty1HOME_TotalIndexSiteSingleParentsexmaleChildAge

Final model at dotted line

Exhibit D.4.1.38. Motor tics (current): Parent Rating (lower = better)

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

Motor tics (current): Parent Rating

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 5 10 15 20 25 30

-0.05 0.0 0.05

ComputerExprPreNatlead_1PreNatFillings_1DayCareHomeImpVal1ChdPICA_1YoungerSibsChildAge3ChildAge2MatSpeechDelOlderSibsPreNatFish_1IronDefC5APGARImpVal1PreNatTuna_1MatADHDEngOnlyPreNatHomePro_1MatSTUTTERPreNatOrgMerc_1DayCareCentrImpVal1PreNatIllDrugPctPoverty1_3PctPoverty1_2PreNatNicotine_1MomIQ1SingleParentHOME_TotalIndexPctPoverty1MomEducSiteChdBWT_GrpsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 118

Exhibit D.4.1.39. Phonics tics (current): Parent Rating (lower = better)

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

Phonics tics (current): Parent Rating

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 5 10 15 20 25 30

-0.15 -0.10 -0.05 0.0 0.05 0.10 0.15

C5APGARImpVal1PreNatFish_1ChdPICA_1MatSTUTTERPreNatFillings_1IronDefChildAge3ChildAge2BFMthsCatPctPoverty1_3PctPoverty1_2PreNatlead_1PreNatAlcohol_1PreNatIllDrugPreNatHomePro_1PreNatTuna_1ChildMedHist_1MatSpeechDelMatADHDPreNatNicotine_1DayCareCentrImpVal1HOME_TotalIndexPctPoverty1MomIQ1SiteSingleParentChdBWT_GrpMomEducsexmaleChildAge

Final model at dotted line

Exhibit D.4.1.40. WASI Verbal IQ

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

WASI Verbal IQ

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.3 -0.2 -0.1 0.0 0.1 0.2 0.3

ChildMedHist_1PreNatTuna_1PctPoverty1_3ChildAge3PreNatlead_1PreNatFillings_1MatAgeCatMatSpeechDelPctPoverty1_2PreNatNicotine_1DayCareHomeImpVal1PreNatHomePro_1PreNatAlcohol_1PreNatIllDrugIronDef_1MatADHDChildAge2PreNatOrgMerc_1MatLangDelDayCareCentrImpVal1ChdPICA_1MatSTUTTERADHDstimulantEngOnlyPreNatFish_1C5APGARImpVal1YoungerSibsOlderSibsBFMthsCatSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprChdBWT_GrpsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 119

Exhibit D.4.1.41. WASI Performance IQ

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

WASI: Performance IQ

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.4 -0.2 0.0 0.2 0.4

PreNatTuna_1ChildMedHist_1PctPoverty1_3ChildAge3PreNatHomePro_1MatSpeechDelMatAgeCatDayCareHomeImpVal1PreNatlead_1PreNatOrgMerc_1MatADHDPreNatFillings_1OlderSibsMatSTUTTERChdPICA_1C5APGARImpVal1PreNatIllDrugMatLangDelPctPoverty1_2ChildAge2PreNatNicotine_1PreNatAlcohol_1IronDef_1DayCareCentrImpVal1ADHDstimulantPreNatFish_1YoungerSibsEngOnlyBFMthsCatSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.1.42. WASI Full Scale IQ

Prenatal: Change in Estimate and Precision as Covariates Are Dropped

WASI Full Scale IQ

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.4 -0.2 0.0 0.2 0.4

PctPoverty1_3PreNatAlcohol_1ChildMedHist_1PreNatTuna_1PreNatIllDrugMatAgeCatChdPICA_1MatSpeechDelPreNatlead_1PreNatHomePro_1PreNatOrgMerc_1PreNatFillings_1MatADHDChildAge3ChildAge2PctPoverty1_2DayCareHomeImpVal1PreNatNicotine_1MatLangDelMatSTUTTERIronDef_1DayCareCentrImpVal1C5APGARImpVal1ADHDstimulantPreNatFish_1EngOnlyYoungerSibsOlderSibsBFMthsCatSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprChdBWT_GrpsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 120

4.2. Exp07mos

List of Exhibits Page

Speech and Language

Exhibit D.4.2.1. Boston Naming Test 121

Exhibit D.4.2.2. NEPSY: Speeded Naming 121

Exhibit D.4.2.3. NEPSY: Comprehension of Instructions 122

Exhibit D.4.2.4. CELF: Formulated Sentences 122

Exhibit D.4.2.5. CELF: Recalling Sentences 123

Exhibit D.4.2.6. GFTA: Articulation (lower = better) 123

Exhibit D.4.2.7. Stuttering: Assessor Rating (lower = better) 124

Exhibit D.4.2.8. Stuttering: Parent Rating (lower = better) 124

Exhibit D.4.2.9. Stuttering: Teacher Rating (lower = better) 125

Verbal Memory

Exhibit D.4.2.10. CVLT-C: Free Recall, No Delay 125

Exhibit D.4.2.11. CVLT-C: Free Recall, Short Delay 126

Exhibit D.4.2.12. CVLT-C: Cued Recall, Short Delay 126

Exhibit D.4.2.13. CVLT-C: Free Recall, Long Delay 127

Exhibit D.4.2.14. CVLT-C: Cued Recall, Long Delay 127

Exhibit D.4.2.15. CMS Stories 1: Immediate Recall 128

Exhibit D.4.2.16. CMS Stories 2: Delayed Recall 128

Achievement

Exhibit D.4.2.17. WJIII: Letter- Word Identification 129

Fine Motor Coordination

Exhibit D.4.2.18. Grooved Pegboard: Dominant Hand (lower = better) 129

Exhibit D.4.2.19. Grooved Pegboard: Non-dom Hand (lower = better) 130

Exhibit D.4.2.20. Finger Tapping: Dominant Hand 130

Exhibit D.4.2.31. Finger Tapping: Non-dominant Hand 131

Visual Spatial Ability

Exhibit D.4.2.22. Stanford Binet: Copying 131

Attention/ Executive Functioning

Exhibit D.4.2.23. GDS Vigilance Task: Correct Responses 132

Exhibit D.4.2.24. GDS Vigilance Task: Errors (lower = better) 132

Exhibit D.4.2.25. WISC III: Digit Span, Forward Recall 133

Exhibit D.4.2.26. WISC III: Digit Span, Backward Recall 133

Exhibit D.4.2.27. WISC III: Digit Span, Combined 134

Exhibit D.4.2.28. BRIEF Parent Rating: Metacognition (lower = better) 134

Exhibit D.4.2.29. BRIEF Teacher Rating: Metacognition (lower = better) 135

Behavior Regulation (lower = better)

Exhibit D.4.2.30. CRS-R: Parent Rating: Hyperactive/Impulsive (lower = 135

Exhibit D.4.2.31. CRS-R: Teacher Rating: Hyperactive/Impulsive (lower = 136

Exhibit D.4.2.32. CRS-R: Parent Rating: Inattentive (lower = better) 136

Exhibit D.4.2.33. CRS-R: Teacher Rating: Inattentive (lower = better) 137

Exhibit D.4.2.34. BRIEF Parent Rating: Behavior Regulation (lower = better) 137

Exhibit D.4.2.35. BRIEF Teacher Rating: Behavior Regulation (lower = 138

Tics (lower = better)

Exhibit D.4.2.36. Motor tics (current): Assessor Rating (lower = better) 138

Exhibit D.4.2.37. Phonics tics (current): Assessor Rating (lower = better) 139

Exhibit D.4.2.38. Motor tics (current): Parent Rating (lower = better) 139

Exhibit D.4.2.39. Phonics tics (current): Parent Rating (lower = better) 140

General Intellectual Functioning

Exhibit D.4.2.40. WASI Verbal IQ 140

Exhibit D.4.2.41. WASI Performance IQ 141

Exhibit D.4.2.42. WASI Full Scale IQ 141
Abt Associates, Inc. Appendix D 121

Exhibit D.4.2.1. Boston Naming Tests

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

Boston Naming Test

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30

-0.2 -0.1 0.0 0.1 0.2 0.3

MatADHDADHDstimulantPreNatNicotine_1ChdPICA_1PreNatAlcohol_1ChildAge3PctPoverty1_3PctPoverty1_2DayCareHomeImpVal1DayCareCentrImpVal1PreNatHomePro_1PreNatTuna_1ChildAge2MatLangDelChildMedHist_1EngOnlyPreNatFish_1MatAgeCatMatSTUTTERPreNatFillings_1PreNatlead_1MatSpeechDelYoungerSibsOlderSibsBFMthsCatSiteSingleParentsexmaleMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprChdBWT_CatChildAge

Final model at dotted line

Exhibit D.4.2.2. NEPSY Speeded Naming

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

NEPSY: Speeded Naming

Dropped covariate is shown above model number

Model Number

PreNatThimer Coef

0 10 20 30 40

-0.1 0.0 0.1 0.2

MatSTUTTERDayCareCentrImpVal1C5APGARImpVal1ChdPICA_1PctPoverty1_3PctPoverty1_2EngOnlyADHDstimulantPreNatAlcohol_1PreNatIllDrugChildAge3MatSpeechDelChildAge2PreNatFillings_1YoungerSibsMatAgeCatPreNatlead_1IronDef_1PreNatNicotine_1PreNatHomePro_1ChildMedHist_1PreNatOrgMerc_1ComputerExprPreNatFish_1PreNatTuna_1MatADHDDayCareHomeImpVal1BFMthsCatOlderSibsMatLangDelSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 122

Exhibit D.4.2.3. NEPSY: Comprehension of Instructions

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

NEPSY: Comprehension of Instructions

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30

-0.2 -0.1 0.0 0.1 0.2

PctPoverty1_3ChdPICA_1MatSpeechDelEngOnlyPctPoverty1_2MatAgeCatYoungerSibsMatSTUTTERADHDstimulantPreNatOrgMerc_1PreNatlead_1DayCareHomeImpVal1DayCareCentrImpVal1PreNatFillings_1PreNatHomePro_1PreNatTuna_1ChildAge3ChildAge2MatADHDMatLangDelIronDef_1C5APGARImpVal1PreNatIllDrugPreNatFish_1PreNatAlcohol_1PreNatNicotine_1BFMthsCatOlderSibsSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.2.4. CELF Formulated Sentences

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

CELF: Formulated Sentences

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30 40

-0.3 -0.2 -0.1 0.0 0.1 0.2 0.3MatSpeechDelDayCareHomeImpVal1PreNatFillings_1PreNatTuna_1PreNatIllDrugPreNatFish_1MatAgeCatPreNatlead_1PreNatOrgMerc_1PreNatHomePro_1PreNatNicotine_1MatADHDChdPICA_1PreNatAlcohol_1C5APGARImpVal1YoungerSibsADHDstimulantChildMedHist_1EngOnlyPctPoverty1_3MatSTUTTERChdBWT_GrpPctPoverty1_2DayCareCentrImpVal1IronDef_1ChildAge3ChildAge2OlderSibsMatLangDelBFMthsCatSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 123

Exhibit D.4.2.5. CELF Recalling Sentences

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

CELF: Recalling Sentences

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30 40

-0.4 -0.2 0.0 0.2 0.4

YoungerSibsPreNatIllDrugPreNatHomePro_1ChildMedHist_1PreNatNicotine_1DayCareHomeImpVal1PctPoverty1_3PreNatTuna_1PreNatFillings_1PctPoverty1_2ADHDstimulantMatAgeCatMatLangDelChdPICA_1ComputerExprPreNatOrgMerc_1DayCareCentrImpVal1ChildAge3ChildAge2MatADHDMatSTUTTERMatSpeechDelIronDef_1C5APGARImpVal1PreNatlead_1PreNatFish_1PreNatAlcohol_1BFMthsCatEngOnlyOlderSibsSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.2.6. GFTA Articulation

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

GFTA: Articulation (lower=better)

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30 40

-0.10 -0.05 0.0 0.05 0.10

ADHDstimulantBFMthsCatMatAgeCatEngOnlyYoungerSibsPreNatlead_1PreNatNicotine_1PreNatIllDrugMatSTUTTERPreNatOrgMerc_1ChildAge3ChildAge2PreNatHomePro_1ChildMedHist_1DayCareCentrImpVal1DayCareHomeImpVal1PreNatFillings_1PreNatFish_1PreNatTuna_1ChdPICA_1ComputerExprChdBWT_GrpPctPoverty1_3PctPoverty1_2MatADHDMatSpeechDelMatLangDelIronDef_1C5APGARImpVal1PreNatAlcohol_1OlderSibsSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1sexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 124

Exhibit D.4.2.7. Stuttering Assessor Rating

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

Stuttering: Assessor Rating (lower=better)

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

5 10 15 20

-0.2 -0.1 0.0 0.1 0.2 0.3

BFMthsCatMatSpeechDelPreNatOrgMerc_1ChildMedHist_1ChildAge3ChildAge2PctPoverty1_3PctPoverty1_2PreNatAlcohol_1PreNatlead_1MatSTUTTERHOME_TotalIndexMomIQ1SingleParentSiteMomEducsexmalePctPoverty1ChdBWT_GrpChildAge

Final model at dotted line

Exhibit D.4.2.8. Stuttering Parent Rating

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

Stuttering: Parent Rating (lower=better)

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

2 4 6 8

-0.2 -0.1 0.0 0.1 0.2

MomIQ1SingleParentHOME_TotalIndexPctPoverty1sexmaleSiteChdBWT_GrpMomEducChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 125

Exhibit D.4.2.9. Stuttering Teacher Rating

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

Stuttering: Teacher Rating (lower=better)

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 5 10 15 20 25

-0.2 -0.1 0.0 0.1 0.2 0.3

EngOnlyBFMthsCatPreNatFillings_1PreNatNicotine_1PreNatOrgMerc_1PreNatlead_1IronDefPreNatHomePro_1C5APGARImpVal1DayCareCentrImpVal1ChildAge3ChildAge2ComputerExprPreNatFish_1MatLangDelYoungerSibsPctPoverty1_3PctPoverty1_2PreNatAlcohol_1MomIQ1ChdBWT_GrpSingleParentMomEducPctPoverty1HOME_TotalIndexSitesexmaleChildAge

Final model at dotted line

Exhibit D.4.2.10. CVLT-C: Free Recall, No Delay

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

CVLT-C: Free Recall, No Delay

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30 40

-0.3 -0.2 -0.1 0.0 0.1 0.2 0.3

MatAgeCatPreNatTuna_1MatADHDPctPoverty1_3PctPoverty1_2ADHDstimulantOlderSibsDayCareHomeImpVal1DayCareCentrImpVal1ChildAge3PreNatOrgMerc_1ChildAge2PreNatFish_1IronDef_1YoungerSibsPreNatIllDrugPreNatAlcohol_1MatSpeechDelPreNatNicotine_1PreNatHomePro_1ChdBWT_GrpMatSTUTTERPreNatlead_1EngOnlyPreNatFillings_1ChdPICA_1ChildMedHist_1C5APGARImpVal1BFMthsCatMatLangDelSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 126

Exhibit D.4.2.11. CVLT-C: Free Recall, Short Delay

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

CVLT-C: Free Recall, Short Delay

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30 40

-0.15 -0.10 -0.05 0.0 0.05 0.10

IronDef_1PreNatFish_1DayCareCentrImpVal1MatAgeCatChildAge3MatSpeechDelMatSTUTTERBFMthsCatMatADHDPctPoverty1_3OlderSibsADHDstimulantPreNatIllDrugC5APGARImpVal1YoungerSibsComputerExprPreNatNicotine_1PreNatHomePro_1PreNatOrgMerc_1PreNatFillings_1ChdPICA_1ChildMedHist_1PreNatTuna_1DayCareHomeImpVal1PreNatAlcohol_1ChdBWT_GrpPctPoverty1_2PreNatlead_1ChildAge2EngOnlyMatLangDelSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1sexmaleChildAge

Final model at dotted line

Exhibit D.4.2.12. CVLT-C: Cued Recall, Short Delay

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

CVLT-C: Cued Recall, Short Delay

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30 40

-0.15 -0.10 -0.05 0.0 0.05 0.10

PreNatNicotine_1MatAgeCatPreNatFish_1PctPoverty1_3BFMthsCatChildAge3PreNatIllDrugPctPoverty1_2MatSTUTTERDayCareCentrImpVal1MatADHDPreNatlead_1PreNatFillings_1PreNatAlcohol_1ADHDstimulantIronDef_1PreNatTuna_1ChdPICA_1ComputerExprPreNatOrgMerc_1ChildMedHist_1ChildAge2MatSpeechDelMatLangDelC5APGARImpVal1PreNatHomePro_1EngOnlyDayCareHomeImpVal1YoungerSibsOlderSibsSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 127

Exhibit D.4.2.13. CVLT-C: Free Recall, Long Delay

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

CVLT-C: Free Recall, Long Delay

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30 40

-0.10 -0.05 0.0 0.05 0.10

OlderSibsPctPoverty1_3PreNatIllDrugIronDef_1MatAgeCatPreNatFish_1MatADHDMatSpeechDelPreNatAlcohol_1MatSTUTTERPreNatFillings_1ChildAge3PreNatNicotine_1ChdPICA_1ComputerExprPreNatTuna_1BFMthsCatPctPoverty1_2ChildAge2MatLangDelADHDstimulantC5APGARImpVal1PreNatlead_1PreNatHomePro_1PreNatOrgMerc_1EngOnlyDayCareHomeImpVal1DayCareCentrImpVal1YoungerSibsChildMedHist_1SiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.2.14. CVLT-C: Cued Recall, Long Delay

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

CVLT-C: Cued Recall, Long Delay

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30 40

-0.2 -0.1 0.0 0.1 0.2 0.3

ChdPICA_1PctPoverty1_3PctPoverty1_2MatSpeechDelPreNatNicotine_1BFMthsCatOlderSibsChildAge3ChildAge2IronDef_1MatADHDMatSTUTTERPreNatFillings_1MatAgeCatPreNatAlcohol_1C5APGARImpVal1ComputerExprPreNatIllDrugPreNatlead_1PreNatFish_1PreNatTuna_1MatLangDelADHDstimulantPreNatHomePro_1PreNatOrgMerc_1EngOnlyDayCareHomeImpVal1DayCareCentrImpVal1YoungerSibsChildMedHist_1SiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 128

Exhibit D.4.2.15. CMS Stories 1: Immediate Recall

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

CMS Stories 1: Immediate Recall

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30

-0.4 -0.2 0.0 0.2 0.4

PctPoverty1_3MatADHDADHDstimulantPreNatNicotine_1ChdPICA_1PreNatAlcohol_1PctPoverty1_3PctPoverty1_2PreNatHomePro_1MatSpeechDelEngOnlyPreNatFish_1MatAgeCatPreNatFillings_1ChildMedHist_1YoungerSibsPreNatTuna_1MatSTUTTERC5APGARImpVal1IronDef_1ChildAge3ChildAge2MatLangDelPreNatlead_1BFMthsCatDayCareCentrImpVal1OlderSibsSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.2.16. CMS Stories 2: Delayed Recall

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

CMS Stories 2: Delayed Recall

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30 40

-0.4 -0.2 0.0 0.2 0.4

PreNatHomePro_1ADHDstimulantPreNatNicotine_1MatAgeCatPreNatAlcohol_1PreNatFillings_1MatSpeechDelC5APGARImpVal1ChdPICA_1PreNatTuna_1PreNatIllDrugYoungerSibsComputerExprChildMedHist_1PctPoverty1_3PctPoverty1_2PreNatFish_1MatADHDEngOnlyPreNatOrgMerc_1MatSTUTTERPreNatlead_1ChildAge3ChildAge2MatLangDelIronDef_1BFMthsCatDayCareHomeImpVal1DayCareCentrImpVal1OlderSibsSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 129

Exhibit D.4.2.17. WJIII: Letter- Word Identification

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

WJIII Letter-Word Identification

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30 40

-0.2 -0.1 0.0 0.1 0.2 0.3

PreNatNicotine_1MatAgeCatMatSTUTTERChildMedHist_1DayCareCentrImpVal1PreNatHomePro_1ChdPICA_1IronDef_1C5APGARImpVal1PreNatIllDrugDayCareHomeImpVal1PreNatFillings_1PctPoverty1_3PreNatTuna_1ADHDstimulantMatLangDelChildAge3HOME_TotalIndexsexmalePreNatOrgMerc_1PreNatFish_1PreNatlead_1SingleParentBFMthsCatChdBWT_GrpPreNatAlcohol_1PctPoverty1_2YoungerSibsEngOnlyOlderSibsMatSpeechDelMatADHDChildAge2MomEducPctPoverty1SiteMomIQ1ComputerExprChildAge

Final model at dotted line

Exhibit D.4.2.18. Grooved Pegboard: Dominant Hand (lower = better)

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

Grooved Pegboard: Dominant Hand (lower=better)

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30 40

-0.6 -0.4 -0.2 0.0 0.2 0.4

ChildAge2_Spline9ChildAge2ChildAge_Spline9ChildAge2_Spline9YoungerSibsMatAgeCatMatSpeechDelMatSTUTTERADHDstimulantPctPoverty1_3PreNatNicotine_1OlderSibsPctPoverty1_2PreNatlead_1ChdPICA_1PreNatFillings_1DayCareCentrImpVal1PreNatTuna_1PreNatHomePro_1ChildMedHist_1ComputerExprPreNatAlcohol_1PreNatOrgMerc_1BFMthsCatMatADHDPreNatFish_1EngOnlyDayCareHomeImpVal1MatLangDelSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleSpline9ChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 130

Exhibit D.4.2.19. Grooved Pegboard: Non-dom Hand (lower = better)

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

Grooved Pegboard: Dominant Hand (lower=better)

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30 40

-0.6 -0.4 -0.2 0.0 0.2 0.4

ChildAge2_Spline9ChildAge2ChildAge_Spline9ChildAge2_Spline9YoungerSibsMatAgeCatMatSpeechDelMatSTUTTERADHDstimulantPctPoverty1_3PreNatNicotine_1OlderSibsPctPoverty1_2PreNatlead_1ChdPICA_1PreNatFillings_1DayCareCentrImpVal1PreNatTuna_1PreNatHomePro_1ComputerExprChildMedHist_1PreNatAlcohol_1PreNatOrgMerc_1BFMthsCatMatADHDPreNatFish_1EngOnlyDayCareHomeImpVal1MatLangDelSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleSpline9ChildAge

Final model at dotted line

Exhibit D.4.2.20. Finger Tapping: Dominant Hand

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

Finger Tapping: Dominant Hand

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30 40

-0.2 -0.1 0.0 0.1 0.2 0.3

MatSpeechDelPreNatFish_1ADHDstimulantPreNatHomePro_1C5APGARImpVal1PreNatNicotine_1PreNatOrgMerc_1ChildAge3PreNatIllDrugMatSTUTTERPreNatAlcohol_1PctPoverty1_3IronDef_1PctPoverty1_2PreNatTuna_1ChdPICA_1DayCareHomeImpVal1PreNatlead_1PreNatFillings_1ChildMedHist_1OlderSibsDayCareCentrImpVal1YoungerSibsMatAgeCatEngOnlyChildAge2BFMthsCatMatLangDelMatADHDMomIQ1ChdBWT_CatSingleParentPctPoverty1SiteMomEducHOME_TotalIndexComputerExprsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 131

x

Exhibit D.4.2.21. Finger Tapping: Non-dominant Hand

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

Finger Tapping: Non-dominant Hand

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30

-0.2 -0.1 0.0 0.1 0.2 0.3

C5APGARImpVal1PctPoverty1_3MatSTUTTERDayCareHomeImpVal1PreNatTuna_1ChdPICA_1PreNatNicotine_1IronDef_1PreNatIllDrugMatSpeechDelADHDstimulantPreNatOrgMerc_1ChildMedHist_1PreNatFillings_1EngOnlyOlderSibsChildAge3ChildAge2ChdBWT_GrpPreNatlead_1PreNatHomePro_1PreNatAlcohol_1MatAgeCatPctPoverty1_2YoungerSibsPreNatFish_1DayCareCentrImpVal1MatLangDelMatADHDSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprsexmaleChildAge

Final model at dotted line

Exhibit D.4.2.22. Stanford Binet: Copying

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

Stanford Binet: Copying

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30 40

-0.10 -0.05 0.0 0.05 0.10 0.15

BFMthsCatDayCareCentrImpVal1PreNatIllDrugPreNatOrgMerc_1ADHDstimulantYoungerSibsMatSTUTTERPreNatHomePro_1MatADHDPreNatlead_1ChdPICA_1MatSpeechDelChildMedHist_1C5APGARImpVal1PreNatFish_1PreNatTuna_1PreNatNicotine_1ChildAge3ComputerExprOlderSibsDayCareHomeImpVal1MatAgeCatPreNatAlcohol_1PctPoverty1_3PctPoverty1_2ChildAge2MatLangDelIronDef_1PreNatFillings_1EngOnlySiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 132

Exhibit D.4.2.23. GDS Vigilance Task: Correct Responses

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

GDS Vigilance Task: Correct Responses

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30 40

-0.2 -0.1 0.0 0.1 0.2 0.3

YoungerSibsPreNatFish_1MatADHDEngOnlyPctPoverty1_3DayCareCentrImpVal1ChdBWT_GrpOlderSibsPreNatFillings_1ChdPICA_1MatSTUTTERPreNatAlcohol_1PreNatIllDrugMatAgeCatChildMedHist_1PreNatNicotine_1IronDef_1ADHDstimulantMatLangDelPreNatOrgMerc_1PreNatlead_1PreNatTuna_1DayCareHomeImpVal1ChildAge3ChildAge2PreNatHomePro_1C5APGARImpVal1MatSpeechDelPctPoverty1_2BFMthsCatSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprsexmaleChildAge

Final model at dotted line

Exhibit D.4.2.24. GDS Vigilance Task: Errors (lower=better)

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

GDS Vigilance Task: Errors (lower=better)

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30 40

-0.4 -0.2 0.0 0.2

PreNatHomePro_1PreNatlead_1PreNatFillings_1EngOnlyPreNatFish_1PreNatIllDrugMatAgeCatChildMedHist_1DayCareCentrImpVal1ChdBWT_GrpChildAge3ChildAge2PctPoverty1_3PctPoverty1_2DayCareHomeImpVal1C5APGARImpVal1PreNatAlcohol_1OlderSibsMatADHDADHDstimulantIronDef_1MatSTUTTERPreNatOrgMerc_1ChdPICA_1PreNatTuna_1YoungerSibsPreNatNicotine_1BFMthsCatMatSpeechDelMatLangDelSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 133

Exhibit D.4.2.25. WISC III: Digit Span, Forward Recall

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

WISC III: Digit Span, Forward Recall

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30 40

-0.05 0.0 0.05

PreNatIllDrugDayCareCentrImpVal1EngOnlyChdPICA_1IronDef_1YoungerSibsDayCareHomeImpVal1PreNatFillings_1MatADHDPreNatTuna_1ChildMedHist_1MatSpeechDelPreNatOrgMerc_1BFMthsCatOlderSibsComputerExprMatAgeCatPreNatHomePro_1PreNatAlcohol_1PctPoverty1_3PctPoverty1_2ChildAge3ChildAge2MatSTUTTERMatLangDelADHDstimulantC5APGARImpVal1PreNatlead_1PreNatFish_1PreNatNicotine_1SiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.2.26. WISC III: Digit Span, Backward Recall

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

WISC III: Digit Span, Backward Recall

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30 40

-0.05 0.0 0.05 0.10

ComputerExprDayCareHomeImpVal1PctPoverty1_3MatAgeCatIronDef_1PreNatNicotine_1PreNatTuna_1C5APGARImpVal1MatSTUTTERPreNatOrgMerc_1PreNatFillings_1DayCareCentrImpVal1PreNatAlcohol_1YoungerSibsMatSpeechDelMatLangDelPreNatHomePro_1DayCareCentrImpVal1ChildMedHist_1ChdPICA_1PreNatFish_1OlderSibsPreNatlead_1ChildAge3ChildAge2EngOnlyADHDstimulantBFMthsCatsexmaleMomEducPctPoverty1HOME_TotalIndexSingleParentSitePreNatIllDrugMatADHDMomIQ1ChdBWT_CatChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 134

Exhibit D.4.2.27. WISC III: Digit Span, Combined

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

WISC III: Digit Span, Combined

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30 40

-0.15 -0.10 -0.05 0.0 0.05 0.10 0.15

PreNatFillings_1PreNatHomePro_1DayCareCentrImpVal1DayCareHomeImpVal1IronDef_1MatAgeCatYoungerSibsChildAge3ChildAge2PreNatTuna_1PreNatNicotine_1ComputerExprChdPICA_1EngOnlyPreNatOrgMerc_1PreNatAlcohol_1MatSpeechDelMatSTUTTERChildMedHist_1PctPoverty1_3PctPoverty1_2OlderSibsMatADHDMatLangDelADHDstimulantC5APGARImpVal1PreNatIllDrugPreNatlead_1PreNatFish_1BFMthsCatSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.2.28. BRIEF Parent Rating: Metacognition (lower = better)

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

BRIEF Parent Rating: Metacognition (lower=better)

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30 40

-0.6 -0.4 -0.2 0.0 0.2 0.4

PctPoverty1_3IronDef_1YoungerSibsBFMthsCatOlderSibsPreNatIllDrugMatAgeCatMatSTUTTERMatSpeechDelPreNatFish_1PreNatFillings_1PctPoverty1_2ChildMedHist_1ChildAge3ChildAge2PreNatlead_1C5APGARImpVal1PreNatHomePro_1MatADHDMatLangDelChdPICA_1ADHDstimulantPreNatOrgMerc_1PreNatTuna_1PreNatAlcohol_1PreNatNicotine_1EngOnlyDayCareHomeImpVal1DayCareCentrImpVal1SiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprChdBWT_GrpsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 135

Exhibit D.4.2.29. BRIEF Teacher Rating: Metacognition (lower = better)

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

BRIEF Teacher Rating: Metacognition (lower=better)

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30 40

-0.5 0.0 0.5

MatSpeechDelOlderSibsPreNatIllDrugChildAge3PreNatFish_1PctPoverty1_3ChdPICA_1IronDef_1MatLangDelYoungerSibsComputerExprChildMedHist_1MatAgeCatPreNatlead_1PreNatHomePro_1C5APGARImpVal1MatSTUTTERChildAge2DayCareHomeImpVal1PreNatNicotine_1PctPoverty1_2MatADHDADHDstimulantPreNatFillings_1PreNatOrgMerc_1PreNatTuna_1PreNatAlcohol_1BFMthsCatEngOnlyDayCareCentrImpVal1SiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.2.30. CRS-R: Parent Rating: Hyperactive/Impulsive (lower = better)

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

CRS-R: Parent Rating: Hyperactive/Impulsive

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30 40

-0.2 -0.1 0.0 0.1 0.2 0.3

MatLangDelChildMedHist_1ChildAge3IronDef_1PreNatFish_1PreNatlead_1ChildAge2PctPoverty1_3MatSpeechDelPreNatIllDrugPreNatFillings_1YoungerSibsC5APGARImpVal1MatSTUTTEREngOnlyPreNatOrgMerc_1PreNatTuna_1ComputerExprMatAgeCatBFMthsCatPreNatAlcohol_1PctPoverty1_2MatADHDChdPICA_1ADHDstimulantPreNatHomePro_1PreNatNicotine_1DayCareHomeImpVal1DayCareCentrImpVal1OlderSibsSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 136

Exhibit D.4.2.31. CRS-R: Teacher Rating: Hyperactive/Impulsive (lower = better)

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

CRS-R: Teacher Rating: Hyperactive/Impulsive

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30 40

-0.3 -0.2 -0.1 0.0 0.1 0.2 0.3PreNatAlcohol_1ChdPICA_1PreNatFillings_1PreNatHomePro_1PreNatNicotine_1OlderSibsPreNatlead_1MatAgeCatPctPoverty1_3MatSpeechDelMatLangDelMatADHDDayCareHomeImpVal1YoungerSibsMatSTUTTERPreNatFish_1ChildAge3ChildAge2ComputerExprIronDef_1ChildMedHist_1C5APGARImpVal1PctPoverty1_2ADHDstimulantPreNatIllDrugPreNatOrgMerc_1PreNatTuna_1BFMthsCatEngOnlyDayCareCentrImpVal1SiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.2.32. CRS-R: Parent Rating: Inattentive (lower = better)

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

CRS-R: Parent Rating: Inattentive

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30 40

-0.3 -0.2 -0.1 0.0 0.1 0.2 0.3

PreNatHomePro_1MatSTUTTERYoungerSibsPctPoverty1_3PreNatOrgMerc_1BFMthsCatOlderSibsMatSpeechDelMatAgeCatC5APGARImpVal1PreNatlead_1IronDef_1PreNatFillings_1ChildAge3PreNatIllDrugChildMedHist_1ChildAge2EngOnlyDayCareCentrImpVal1MatLangDelPreNatFish_1ChdPICA_1PreNatNicotine_1PreNatAlcohol_1PreNatTuna_1PctPoverty1_2MatADHDDayCareHomeImpVal1ADHDstimulantSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprChdBWT_CatsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 137

Exhibit D.4.2.33. CRS-R: Teacher Rating: Inattentive (lower = better)

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

CRS-R: Teacher Rating: Inattentive

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30 40

-0.4 -0.2 0.0 0.2

OlderSibsPreNatlead_1PreNatIllDrugPctPoverty1_3MatSpeechDelPreNatFish_1YoungerSibsDayCareHomeImpVal1ChdPICA_1C5APGARImpVal1MatSTUTTEREngOnlyPreNatOrgMerc_1PctPoverty1_2ChildAge3ChildAge2MatAgeCatIronDef_1PreNatAlcohol_1PreNatHomePro_1ChildMedHist_1MatLangDelMatADHDBFMthsCatADHDstimulantPreNatNicotine_1PreNatTuna_1PreNatFillings_1DayCareHomeImpVal1SiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.2.34. BRIEF Parent Rating: Behavior Regulation (lower = better)

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

BRIEF Parent Rating: Behavior Regulation

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30 40

-0.4 -0.2 0.0 0.2 0.4

MatLangDelC5APGARImpVal1MatSTUTTERMatSpeechDelPreNatIllDrugIronDef_1PctPoverty1_3PreNatOrgMerc_1PreNatlead_1MatAgeCatChildAge3YoungerSibsBFMthsCatChildAge2PreNatFish_1PreNatFillings_1ComputerExprEngOnlyPreNatAlcohol_1ChdBWT_GrpChildMedHist_1PreNatTuna_1OlderSibsPreNatHomePro_1DayCareHomeImpVal1PreNatNicotine_1ChdPICA_1PctPoverty1_2DayCareCentrImpVal1ADHDstimulantMatADHDSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1sexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 138

Exhibit D.4.2.35. BRIEF Teacher Rating: Behavior Regulation (lower = better)

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

BRIEF Teacher Rating: Behavior Regulation

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30 40

-0.4 -0.2 0.0 0.2 0.4

PreNatFillings_1MatLangDelMatAgeCatChildAge3PreNatIllDrugPreNatFish_1PreNatTuna_1IronDef_1MatSpeechDelComputerExprChdPICA_1PreNatOrgMerc_1PreNatHomePro_1MatSTUTTERDayCareHomeImpVal1PreNatNicotine_1ChildAge2C5APGARImpVal1BFMthsCatPreNatAlcohol_1PctPoverty1_3PctPoverty1_2MatADHDADHDstimulantPreNatlead_1EngOnlyDayCareCentrImpVal1YoungerSibsOlderSibsChildMedHist_1SiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.2.36. Motor tics (current): Assessor Rating (lower = better)

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

Motor tics (current): Assessor Rating

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

5 10 15 20 25

-0.1 0.0 0.1

EngOnlyPreNatHomePro_1DayCareCentrImpVal1PctPoverty1_3PctPoverty1_2DayCareHomeImpVal1MatSTUTTERC5APGARImpVal1PreNatAlcohol_1IronDefPreNatTuna_1PreNatFish_1BFMthsCatChildMedHist_1ChildAge3ChildAge2ComputerExprHOME_TotalIndexSingleParentMomEducChdBWT_GrpMomIQ1PctPoverty1SiteChildAgesexmale

Final model at dotted line
Abt Associates, Inc. Appendix D 139

Exhibit D.4.2.37. Phonics tics (current): Assessor Rating (lower = better)

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

Phonics tics (current): Assessor Rating

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

5 10 15 20

-0.1 0.0 0.1 0.2

IronDefChildAge3BFMthsCatC5APGARImpVal1DayCareCentrImpVal1ChildAge2ComputerExprChdPICA_1PreNatAlcohol_1PreNatHomePro_1PctPoverty1_3PctPoverty1_2PreNatTuna_1PreNatFish_1DayCareHomeImpVal1ChdBWT_GrpMomIQ1MomEducPctPoverty1HOME_TotalIndexSiteSingleParentsexmaleChildAge

Final model at dotted line

Exhibit D.4.2.38. Motor tics (current): Parent Rating (lower = better)

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

Motor tics (current): Parent Rating

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 5 10 15 20 25 30

-0.1 0.0 0.1

ComputerExprPreNatlead_1PreNatFillings_1DayCareHomeImpVal1ChdPICA_1YoungerSibsChildAge3ChildAge2MatSpeechDelOlderSibsPreNatFish_1IronDefC5APGARImpVal1PreNatTuna_1MatADHDEngOnlyPreNatHomePro_1MatSTUTTERPreNatOrgMerc_1DayCareCentrImpVal1PreNatIllDrugPctPoverty1_3PctPoverty1_2PreNatNicotine_1MomIQ1SingleParentHOME_TotalIndexPctPoverty1MomEducSiteChdBWT_GrpsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 140

Exhibit D.4.2.39. Phonics tics (current): Parent Rating (lower = better)

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

Phonics tics (current): Parent Rating

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 5 10 15 20 25 30

-0.10 -0.05 0.0 0.05 0.10

C5APGARImpVal1PreNatFish_1ChdPICA_1MatSTUTTERPreNatFillings_1IronDefChildAge3ChildAge2BFMthsCatPctPoverty1_3PctPoverty1_2PreNatlead_1PreNatAlcohol_1PreNatIllDrugPreNatHomePro_1PreNatTuna_1ChildMedHist_1MatSpeechDelMatADHDPreNatNicotine_1DayCareCentrImpVal1HOME_TotalIndexPctPoverty1MomIQ1SiteSingleParentChdBWT_GrpMomEducsexmaleChildAge

Final model at dotted line

Exhibit D.4.2.40. WASI Verbal IQ

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

WASI Verbal IQ

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30 40

-0.4 -0.2 0.0 0.2 0.4

ChildMedHist_1PreNatTuna_1PctPoverty1_3ChildAge3PreNatlead_1PreNatFillings_1MatAgeCatMatSpeechDelPctPoverty1_2PreNatNicotine_1DayCareHomeImpVal1PreNatHomePro_1PreNatAlcohol_1PreNatIllDrugIronDef_1MatADHDChildAge2PreNatOrgMerc_1MatLangDelDayCareCentrImpVal1ChdPICA_1MatSTUTTERADHDstimulantEngOnlyPreNatFish_1C5APGARImpVal1YoungerSibsOlderSibsBFMthsCatSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprChdBWT_GrpsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 141

Exhibit D.4.2.41. WASI Performance IQ

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

WASI: Performance IQ

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30 40

-0.4 -0.2 0.0 0.2 0.4 0.6

PreNatTuna_1ChildMedHist_1PctPoverty1_3ChildAge3PreNatHomePro_1MatSpeechDelMatAgeCatDayCareHomeImpVal1PreNatlead_1PreNatOrgMerc_1MatADHDPreNatFillings_1OlderSibsMatSTUTTERChdPICA_1C5APGARImpVal1PreNatIllDrugMatLangDelPctPoverty1_2ChildAge2PreNatNicotine_1PreNatAlcohol_1IronDef_1DayCareCentrImpVal1ADHDstimulantPreNatFish_1YoungerSibsEngOnlyBFMthsCatSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.2.42. WASI Full Scale IQ

Exp07mos: Change in Estimate and Precision as Covariates Are Dropped

WASI Full Scale IQ

Dropped covariate is shown above model number

Model Number

Exp07mos Coef

0 10 20 30 40

-0.4 -0.2 0.0 0.2 0.4 0.6

PctPoverty1_3PreNatAlcohol_1ChildMedHist_1PreNatTuna_1PreNatIllDrugMatAgeCatChdPICA_1MatSpeechDelPreNatlead_1PreNatHomePro_1PreNatOrgMerc_1PreNatFillings_1MatADHDChildAge3ChildAge2PctPoverty1_2DayCareHomeImpVal1PreNatNicotine_1MatLangDelMatSTUTTERIronDef_1DayCareCentrImpVal1C5APGARImpVal1ADHDstimulantPreNatFish_1EngOnlyYoungerSibsOlderSibsBFMthsCatSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprChdBWT_GrpsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 142

4.3. HepB

List of Exhibits Page

Speech and Language

Exhibit D.4.3.1. Boston Naming Test 143

Exhibit D.4.3.2. NEPSY: Speeded Naming 143

Exhibit D.4.3.3. NEPSY: Comprehension of Instructions 144

Exhibit D.4.3.4. CELF: Formulated Sentences 144

Exhibit D.4.3.5. CELF: Recalling Sentences 145

Exhibit D.4.3.6. GFTA: Articulation (lower = better) 145

Exhibit D.4.3.7. Stuttering: Assessor Rating (lower = better) 146

Exhibit D.4.3.8. Stuttering: Parent Rating (lower = better) 146

Exhibit D.4.3.9. Stuttering: Teacher Rating (lower = better) 147

Verbal Memory

Exhibit D.4.3.10. CVLT-C: Free Recall, No Delay 147

Exhibit D.4.3.11. CVLT-C: Free Recall, Short Delay 148

Exhibit D.4.3.12. CVLT-C: Cued Recall, Short Delay 148

Exhibit D.4.3.13. CVLT-C: Free Recall, Long Delay 149

Exhibit D.4.3.14. CVLT-C: Cued Recall, Long Delay 149

Exhibit D.4.3.15. CMS Stories 1: Immediate Recall 150

Exhibit D.4.3.16. CMS Stories 2: Delayed Recall 150

Achievement

Exhibit D.4.3.17. WJIII: Letter- Word Identification 151

Fine Motor Coordination

Exhibit D.4.3.18. Grooved Pegboard: Dominant Hand (lower = better) 151

Exhibit D.4.3.19. Grooved Pegboard: Non-dom Hand (lower = better) 152

Exhibit D.4.3.20. Finger Tapping: Dominant Hand 152

Exhibit D.4.3.31. Finger Tapping: Non-dominant Hand 153

Visual Spatial Ability

Exhibit D.4.3.22. Stanford Binet: Copying 153

Attention/ Executive Functioning

Exhibit D.4.3.23. GDS Vigilance Task: Correct Responses 154

Exhibit D.4.3.24. GDS Vigilance Task: Errors (lower = better) 154

Exhibit D.4.3.25. WISC III: Digit Span, Forward Recall 155

Exhibit D.4.3.26. WISC III: Digit Span, Backward Recall 155

Exhibit D.4.3.27. WISC III: Digit Span, Combined 156

Exhibit D.4.3.28. BRIEF Parent Rating: Metacognition (lower = better) 156

Exhibit D.4.3.29. BRIEF Teacher Rating: Metacognition (lower = better) 157

Behavior Regulation (lower = better)

Exhibit D.4.3.30. CRS-R: Parent Rating: Hyperactive/Impulsive (lower = 157

Exhibit D.4.3.31. CRS-R: Teacher Rating: Hyperactive/Impulsive (lower = 158

Exhibit D.4.3.32. CRS-R: Parent Rating: Inattentive (lower = better) 158

Exhibit D.4.3.33. CRS-R: Teacher Rating: Inattentive (lower = better) 159

Exhibit D.4.3.34. BRIEF Parent Rating: Behavior Regulation (lower = better) 159

Exhibit D.4.3.35. BRIEF Teacher Rating: Behavior Regulation (lower = 160

Tics (lower = better)

Exhibit D.4.3.36. Motor tics (current): Assessor Rating (lower = better) 160

Exhibit D.4.3.37. Phonics tics (current): Assessor Rating (lower = better) 161

Exhibit D.4.3.38. Motor tics (current): Parent Rating (lower = better) 161

Exhibit D.4.3.39. Phonics tics (current): Parent Rating (lower = better) 162

General Intellectual Functioning

Exhibit D.4.3.40. WASI Verbal IQ 162

Exhibit D.4.3.41. WASI Performance IQ 163

Exhibit D.4.3.42. WASI Full Scale IQ 163
Abt Associates, Inc. Appendix D 143

Exhibit D.4.3.1. Boston Naming Test

HepB: Change in Estimate and Precision as Covariates Are Dropped

Boston Naming Test

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30

-1.0 -0.5 0.0 0.5

MatADHDADHDstimulantPreNatNicotine_1ChdPICA_1PreNatAlcohol_1ChildAge3PctPoverty1_3PctPoverty1_2DayCareHomeImpVal1DayCareCentrImpVal1PreNatHomePro_1PreNatTuna_1ChildAge2MatLangDelChildMedHist_1EngOnlyPreNatFish_1MatAgeCatMatSTUTTERPreNatFillings_1PreNatlead_1MatSpeechDelYoungerSibsOlderSibsBFMthsCatSiteSingleParentsexmaleMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprChdBWT_CatChildAge

Final model at dotted line

Exhibit D.4.3.2. NEPSY Speeded Naming

HepB: Change in Estimate and Precision as Covariates Are Dropped

NEPSY: Speeded Naming

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-1.0 -0.5 0.0 0.5 1.0

MatSTUTTERDayCareCentrImpVal1C5APGARImpVal1ChdPICA_1PctPoverty1_3PctPoverty1_2EngOnlyADHDstimulantPreNatAlcohol_1PreNatIllDrugChildAge3MatSpeechDelChildAge2PreNatFillings_1YoungerSibsMatAgeCatPreNatlead_1IronDef_1PreNatNicotine_1PreNatHomePro_1ChildMedHist_1PreNatOrgMerc_1ComputerExprPreNatFish_1PreNatTuna_1MatADHDDayCareHomeImpVal1BFMthsCatOlderSibsMatLangDelSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 144

Exhibit D.4.3.3. NEPSY: Comprehension of Instructions

HepB: Change in Estimate and Precision as Covariates Are Dropped

NEPSY: Comprehension of Instructions

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30

-0.4 -0.2 0.0 0.2 0.4

PctPoverty1_3ChdPICA_1MatSpeechDelEngOnlyPctPoverty1_2MatAgeCatYoungerSibsMatSTUTTERADHDstimulantPreNatOrgMerc_1PreNatlead_1DayCareHomeImpVal1DayCareCentrImpVal1PreNatFillings_1PreNatHomePro_1PreNatTuna_1ChildAge3ChildAge2MatADHDMatLangDelIronDef_1C5APGARImpVal1PreNatIllDrugPreNatFish_1PreNatAlcohol_1PreNatNicotine_1BFMthsCatOlderSibsSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.3.4. CELF Formulated Sentences

HepB: Change in Estimate and Precision as Covariates Are Dropped

CELF: Formulated Sentences

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-1.0 -0.5 0.0 0.5

MatSpeechDelDayCareHomeImpVal1PreNatFillings_1PreNatTuna_1PreNatIllDrugPreNatFish_1MatAgeCatPreNatlead_1PreNatOrgMerc_1PreNatHomePro_1PreNatNicotine_1MatADHDChdPICA_1PreNatAlcohol_1C5APGARImpVal1YoungerSibsADHDstimulantChildMedHist_1EngOnlyPctPoverty1_3MatSTUTTERChdBWT_GrpPctPoverty1_2DayCareCentrImpVal1IronDef_1ChildAge3ChildAge2OlderSibsMatLangDelBFMthsCatSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 145

Exhibit D.4.3.5. CELF Recalling Sentences

HepB: Change in Estimate and Precision as Covariates Are Dropped

CELF: Recalling Sentences

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-1.5 -1.0 -0.5 0.0 0.5 1.0

YoungerSibsPreNatIllDrugPreNatHomePro_1ChildMedHist_1PreNatNicotine_1DayCareHomeImpVal1PctPoverty1_3PreNatTuna_1PreNatFillings_1PctPoverty1_2ADHDstimulantMatAgeCatMatLangDelChdPICA_1ComputerExprPreNatOrgMerc_1DayCareCentrImpVal1ChildAge3ChildAge2MatADHDMatSTUTTERMatSpeechDelIronDef_1C5APGARImpVal1PreNatlead_1PreNatFish_1PreNatAlcohol_1BFMthsCatEngOnlyOlderSibsSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.3.6. GFTA Articulation

HepB: Change in Estimate and Precision as Covariates Are Dropped

GFTA: Articulation (lower=better)

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-0.4 -0.2 0.0 0.2 0.4

ADHDstimulantBFMthsCatMatAgeCatEngOnlyYoungerSibsPreNatlead_1PreNatNicotine_1PreNatIllDrugMatSTUTTERPreNatOrgMerc_1ChildAge3ChildAge2PreNatHomePro_1ChildMedHist_1DayCareCentrImpVal1DayCareHomeImpVal1PreNatFillings_1PreNatFish_1PreNatTuna_1ChdPICA_1ComputerExprChdBWT_GrpPctPoverty1_3PctPoverty1_2MatADHDMatSpeechDelMatLangDelIronDef_1C5APGARImpVal1PreNatAlcohol_1OlderSibsSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1sexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 146

Exhibit D.4.3.7. Stuttering Assessor Rating

HepB: Change in Estimate and Precision as Covariates Are Dropped

Stuttering: Assessor Rating (lower=better)

Dropped covariate is shown above model number

Model Number

HepB Coef

5 10 15 20

-1.0 -0.5 0.0 0.5 1.0

BFMthsCatMatSpeechDelPreNatOrgMerc_1cMedicalHist_1ChildAge3ChildAge2PctPoverty1_3PctPoverty1_2PreNatAlcohol_1PreNatlead_1MatSTUTTERHOME_TotalIndexMomIQ1SingleParentSiteMomEducsexmalePctPoverty1ChdBWT_GrpChildAge

Final model at dotted line

Exhibit D.4.3.8. Stuttering Parent Rating

HepB: Change in Estimate and Precision as Covariates Are Dropped

Stuttering: Parent Rating (lower=better)

Dropped covariate is shown above model number

Model Number

HepB Coef

2 4 6 8

-1.0 -0.5 0.0 0.5 1.0

MomIQ1SingleParentHOME_TotalIndexPctPoverty1sexmaleSiteChdBWT_GrpMomEducChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 147

Exhibit D.4.3.9. Stuttering Teacher Rating

HepB: Change in Estimate and Precision as Covariates Are Dropped

Stuttering: Teacher Rating (lower=better)

Dropped covariate is shown above model number

Model Number

HepB Coef

0 5 10 15 20 25

-0.5 0.0 0.5

EngOnlyBFMthsCatPreNatFillings_1PreNatNicotine_1PreNatOrgMerc_1PreNatlead_1IronDefPreNatHomePro_1C5APGARImpVal1DayCareCentrImpVal1ChildAge3ChildAge2ComputerExprPreNatFish_1MatLangDelYoungerSibsPctPoverty1_3PctPoverty1_2PreNatAlcohol_1MomIQ1ChdBWT_GrpSingleParentMomEducPctPoverty1HOME_TotalIndexSitesexmaleChildAge

Final model at dotted line

Exhibit D.4.3.10. CVLT-C: Free Recall, No Delay

HepB: Change in Estimate and Precision as Covariates Are Dropped

CVLT-C: Free Recall, No Delay

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-1.0 -0.5 0.0 0.5 1.0

MatAgeCatPreNatTuna_1MatADHDPctPoverty1_3PctPoverty1_2ADHDstimulantOlderSibsDayCareHomeImpVal1DayCareCentrImpVal1ChildAge3PreNatOrgMerc_1ChildAge2PreNatFish_1IronDef_1YoungerSibsPreNatIllDrugPreNatAlcohol_1MatSpeechDelPreNatNicotine_1PreNatHomePro_1ChdBWT_GrpMatSTUTTERPreNatlead_1EngOnlyPreNatFillings_1ChdPICA_1ChildMedHist_1C5APGARImpVal1BFMthsCatMatLangDelSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 148

Exhibit D.4.3.11. CVLT-C: Free Recall, Short Delay

HepB: Change in Estimate and Precision as Covariates Are Dropped

CVLT-C: Free Recall, Short Delay

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-0.4 -0.2 0.0 0.2 0.4

IronDef_1PreNatFish_1DayCareCentrImpVal1MatAgeCatChildAge3MatSpeechDelMatSTUTTERBFMthsCatMatADHDPctPoverty1_3OlderSibsADHDstimulantPreNatIllDrugC5APGARImpVal1YoungerSibsComputerExprPreNatNicotine_1PreNatHomePro_1PreNatOrgMerc_1PreNatFillings_1ChdPICA_1ChildMedHist_1PreNatTuna_1DayCareHomeImpVal1PreNatAlcohol_1ChdBWT_GrpPctPoverty1_2PreNatlead_1ChildAge2EngOnlyMatLangDelSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1sexmaleChildAge

Final model at dotted line

Exhibit D.4.3.12. CVLT-C: Cued Recall, Short Delay

HepB: Change in Estimate and Precision as Covariates Are Dropped

CVLT-C: Cued Recall, Short Delay

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-0.4 -0.2 0.0 0.2 0.4

PreNatNicotine_1MatAgeCatPreNatFish_1PctPoverty1_3BFMthsCatChildAge3PreNatIllDrugPctPoverty1_2MatSTUTTERDayCareCentrImpVal1MatADHDPreNatlead_1PreNatFillings_1PreNatAlcohol_1ADHDstimulantIronDef_1PreNatTuna_1ChdPICA_1ComputerExprPreNatOrgMerc_1ChildMedHist_1ChildAge2MatSpeechDelMatLangDelC5APGARImpVal1PreNatHomePro_1EngOnlyDayCareHomeImpVal1YoungerSibsOlderSibsSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 149

Exhibit D.4.3.13. CVLT-C: Free Recall, Long Delay

HepB: Change in Estimate and Precision as Covariates Are Dropped

CVLT-C: Free Recall, Long Delay

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-0.4 -0.2 0.0 0.2 0.4

OlderSibsPctPoverty1_3PreNatIllDrugIronDef_1MatAgeCatPreNatFish_1MatADHDMatSpeechDelPreNatAlcohol_1MatSTUTTERPreNatFillings_1ChildAge3PreNatNicotine_1ChdPICA_1ComputerExprPreNatTuna_1BFMthsCatPctPoverty1_2ChildAge2MatLangDelADHDstimulantC5APGARImpVal1PreNatlead_1PreNatHomePro_1PreNatOrgMerc_1EngOnlyDayCareHomeImpVal1DayCareCentrImpVal1YoungerSibsChildMedHist_1SiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.3.14. CVLT-C: Cued Recall, Long Delay

HepB: Change in Estimate and Precision as Covariates Are Dropped

CVLT-C: Cued Recall, Long Delay

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-0.4 -0.2 0.0 0.2 0.4

ChdPICA_1PctPoverty1_3PctPoverty1_2MatSpeechDelPreNatNicotine_1BFMthsCatOlderSibsChildAge3ChildAge2IronDef_1MatADHDMatSTUTTERPreNatFillings_1MatAgeCatPreNatAlcohol_1C5APGARImpVal1ComputerExprPreNatIllDrugPreNatlead_1PreNatFish_1PreNatTuna_1MatLangDelADHDstimulantPreNatHomePro_1PreNatOrgMerc_1EngOnlyDayCareHomeImpVal1DayCareCentrImpVal1YoungerSibsChildMedHist_1SiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 150

Exhibit D.4.3.15. CMS Stories 1: Immediate Recall

HepB: Change in Estimate and Precision as Covariates Are Dropped

CMS Stories 1: Immediate Recall

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30

-1.5 -1.0 -0.5 0.0 0.5 1.0

PctPoverty1_3MatADHDADHDstimulantPreNatNicotine_1ChdPICA_1PreNatAlcohol_1PctPoverty1_3PctPoverty1_2PreNatHomePro_1MatSpeechDelEngOnlyPreNatFish_1MatAgeCatPreNatFillings_1ChildMedHist_1YoungerSibsPreNatTuna_1MatSTUTTERC5APGARImpVal1IronDef_1ChildAge3ChildAge2MatLangDelPreNatlead_1BFMthsCatDayCareCentrImpVal1OlderSibsSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.3.16. CMS Stories 2: Delayed Recall

HepB: Change in Estimate and Precision as Covariates Are Dropped

CMS Stories 2: Delayed Recall

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-1.5 -1.0 -0.5 0.0 0.5 1.0

PreNatHomePro_1ADHDstimulantPreNatNicotine_1MatAgeCatPreNatAlcohol_1PreNatFillings_1MatSpeechDelC5APGARImpVal1ChdPICA_1PreNatTuna_1PreNatIllDrugYoungerSibsComputerExprChildMedHist_1PctPoverty1_3PctPoverty1_2PreNatFish_1MatADHDEngOnlyPreNatOrgMerc_1MatSTUTTERPreNatlead_1ChildAge3ChildAge2MatLangDelIronDef_1BFMthsCatDayCareHomeImpVal1DayCareCentrImpVal1OlderSibsSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 151

Exhibit D.4.3.17. WJIII: Letter- Word Identification

HepB: Change in Estimate and Precision as Covariates Are Dropped

WJIII Letter-Word Identification

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-1.0 -0.5 0.0 0.5

PreNatNicotine_1MatAgeCatMatSTUTTERChildMedHist_1DayCareCentrImpVal1PreNatHomePro_1ChdPICA_1IronDef_1C5APGARImpVal1PreNatIllDrugDayCareHomeImpVal1PreNatFillings_1PctPoverty1_3PreNatTuna_1ADHDstimulantMatLangDelChildAge3HOME_TotalIndexsexmalePreNatOrgMerc_1PreNatFish_1PreNatlead_1SingleParentBFMthsCatChdBWT_GrpPreNatAlcohol_1PctPoverty1_2YoungerSibsEngOnlyOlderSibsMatSpeechDelMatADHDChildAge2MomEducPctPoverty1SiteMomIQ1ComputerExprChildAge

Final model at dotted line

Exhibit D.4.3.18. Grooved Pegboard: Dominant Hand (lower = better)

HepB: Change in Estimate and Precision as Covariates Are Dropped

Grooved Pegboard: Dominant Hand (lower=better)

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-2 -1 0 1

ChildAge2_Spline9ChildAge2ChildAge_Spline9ChildAge2_Spline9YoungerSibsMatAgeCatMatSpeechDelMatSTUTTERADHDstimulantPctPoverty1_3PreNatNicotine_1OlderSibsPctPoverty1_2PreNatlead_1ChdPICA_1PreNatFillings_1DayCareCentrImpVal1PreNatTuna_1PreNatHomePro_1ComputerExprChildMedHist_1PreNatAlcohol_1PreNatOrgMerc_1BFMthsCatMatADHDPreNatFish_1EngOnlyDayCareHomeImpVal1MatLangDelSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleSpline9ChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 152

Exhibit D.4.3.19. Grooved Pegboard: Non-dom Hand (lower = better)

HepB: Change in Estimate and Precision as Covariates Are Dropped

Grooved Pegboard: Non-dominant Hand (lower=better)

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-2 -1 0 1 2

PctPoverty1_3PreNatlead_1ChdPICA_1YoungerSibsMatSpeechDelPreNatFish_1ComputerExprIronDef_1MatADHDPreNatAlcohol_1DayCareCentrImpVal1ChildAge2_Spline9MatSTUTTERC5APGARImpVal1OlderSibsPctPoverty1_2MatAgeCatPreNatIllDrugADHDstimulantMatLangDelPreNatFillings_1PreNatHomePro_1PreNatOrgMerc_1PreNatTuna_1PreNatNicotine_1BFMthsCatEngOnlyDayCareHomeImpVal1ChildMedHist_1SiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge2_Spline9ChildAge2ChildAge_Spline9Spline9ChildAge

Final model at dotted line

Exhibit D.4.3.20. Finger Tapping: Dominant Hand

HepB: Change in Estimate and Precision as Covariates Are Dropped

Finger Tapping: Dominant Hand

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-0.5 0.0 0.5 1.0

MatSpeechDelPreNatFish_1ADHDstimulantPreNatHomePro_1C5APGARImpVal1PreNatNicotine_1PreNatOrgMerc_1ChildAge3PreNatIllDrugMatSTUTTERPreNatAlcohol_1PctPoverty1_3IronDef_1PctPoverty1_2PreNatTuna_1ChdPICA_1DayCareHomeImpVal1PreNatlead_1PreNatFillings_1ChildMedHist_1OlderSibsDayCareCentrImpVal1YoungerSibsMatAgeCatEngOnlyChildAge2BFMthsCatMatLangDelMatADHDMomIQ1ChdBWT_CatSingleParentPctPoverty1SiteMomEducHOME_TotalIndexComputerExprsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 153

Exhibit D.4.3.21. Finger Tapping: Non-dominant Hand

HepB: Change in Estimate and Precision as Covariates Are Dropped

Finger Tapping: Non-dominant Hand

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30

-1.0 -0.5 0.0 0.5 1.0

C5APGARImpVal1PctPoverty1_3MatSTUTTERDayCareHomeImpVal1PreNatTuna_1ChdPICA_1PreNatNicotine_1IronDef_1PreNatIllDrugMatSpeechDelADHDstimulantPreNatOrgMerc_1ChildMedHist_1PreNatFillings_1EngOnlyOlderSibsChildAge3ChildAge2ChdBWT_GrpPreNatlead_1PreNatHomePro_1PreNatAlcohol_1MatAgeCatPctPoverty1_2YoungerSibsPreNatFish_1DayCareCentrImpVal1MatLangDelMatADHDSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprsexmaleChildAge

Final model at dotted line

Exhibit D.4.3.22. Stanford Binet: Copying

HepB: Change in Estimate and Precision as Covariates Are Dropped

Stanford Binet: Copying

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-0.4 -0.2 0.0 0.2 0.4

BFMthsCatDayCareCentrImpVal1PreNatIllDrugPreNatOrgMerc_1ADHDstimulantYoungerSibsMatSTUTTERPreNatHomePro_1MatADHDPreNatlead_1ChdPICA_1MatSpeechDelChildMedHist_1C5APGARImpVal1PreNatFish_1PreNatTuna_1PreNatNicotine_1ChildAge3ComputerExprOlderSibsDayCareHomeImpVal1MatAgeCatPreNatAlcohol_1PctPoverty1_3PctPoverty1_2ChildAge2MatLangDelIronDef_1PreNatFillings_1EngOnlySiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 154

Exhibit D.4.3.23. GDS Vigilance Task: Correct Responses

HepB: Change in Estimate and Precision as Covariates Are Dropped

GDS Vigilance Task: Correct Responses

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-0.6 -0.4 -0.2 0.0 0.2 0.4 0.6

YoungerSibsPreNatFish_1MatADHDEngOnlyPctPoverty1_3DayCareCentrImpVal1ChdBWT_GrpOlderSibsPreNatFillings_1ChdPICA_1MatSTUTTERPreNatAlcohol_1PreNatIllDrugMatAgeCatChildMedHist_1PreNatNicotine_1IronDef_1ADHDstimulantMatLangDelPreNatOrgMerc_1PreNatlead_1PreNatTuna_1DayCareHomeImpVal1ChildAge3ChildAge2PreNatHomePro_1C5APGARImpVal1MatSpeechDelPctPoverty1_2BFMthsCatSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprsexmaleChildAge

Final model at dotted line

Exhibit D.4.3.24. GDS Vigilance Task: Errors (lower=better)

HepB: Change in Estimate and Precision as Covariates Are Dropped

GDS Vigilance Task: Errors (lower=better)

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-1.5 -1.0 -0.5 0.0 0.5 1.0 1.5

PreNatHomePro_1PreNatlead_1PreNatFillings_1EngOnlyPreNatFish_1PreNatIllDrugMatAgeCatChildMedHist_1DayCareCentrImpVal1ChdBWT_GrpChildAge3ChildAge2PctPoverty1_3PctPoverty1_2DayCareHomeImpVal1C5APGARImpVal1PreNatAlcohol_1OlderSibsMatADHDADHDstimulantIronDef_1MatSTUTTERPreNatOrgMerc_1ChdPICA_1PreNatTuna_1YoungerSibsPreNatNicotine_1BFMthsCatMatSpeechDelMatLangDelSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 155

Exhibit D.4.3.25. WISC III: Digit Span, Forward Recall

HepB: Change in Estimate and Precision as Covariates Are Dropped

WISC III: Digit Span, Forward Recall

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-0.2 -0.1 0.0 0.1 0.2

PreNatIllDrugDayCareCentrImpVal1EngOnlyChdPICA_1IronDef_1YoungerSibsDayCareHomeImpVal1PreNatFillings_1MatADHDPreNatTuna_1ChildMedHist_1MatSpeechDelPreNatOrgMerc_1BFMthsCatOlderSibsComputerExprMatAgeCatPreNatHomePro_1PreNatAlcohol_1PctPoverty1_3PctPoverty1_2ChildAge3ChildAge2MatSTUTTERMatLangDelADHDstimulantC5APGARImpVal1PreNatlead_1PreNatFish_1PreNatNicotine_1SiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.3.26. WISC III: Digit Span, Backward Recall

HepB: Change in Estimate and Precision as Covariates Are Dropped

WISC III: Digit Span, Backward Recall

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-0.2 -0.1 0.0 0.1 0.2

ComputerExprDayCareHomeImpVal1PctPoverty1_3MatAgeCatIronDef_1PreNatNicotine_1PreNatTuna_1C5APGARImpVal1MatSTUTTERPreNatOrgMerc_1PreNatFillings_1DayCareCentrImpVal1PreNatAlcohol_1YoungerSibsMatSpeechDelMatLangDelPreNatHomePro_1DayCareCentrImpVal1ChildMedHist_1ChdPICA_1PreNatFish_1OlderSibsPreNatlead_1ChildAge3ChildAge2EngOnlyADHDstimulantBFMthsCatsexmaleMomEducPctPoverty1HOME_TotalIndexSingleParentSitePreNatIllDrugMatADHDMomIQ1ChdBWT_CatChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 156

Exhibit D.4.3.27. WISC III: Digit Span, Combined

HepB: Change in Estimate and Precision as Covariates Are Dropped

WISC III: Digit Span, Combined

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-0.3 -0.2 -0.1 0.0 0.1 0.2 0.3

PreNatFillings_1PreNatHomePro_1DayCareCentrImpVal1DayCareHomeImpVal1IronDef_1MatAgeCatYoungerSibsChildAge3ChildAge2PreNatTuna_1PreNatNicotine_1ComputerExprChdPICA_1EngOnlyPreNatOrgMerc_1PreNatAlcohol_1MatSpeechDelMatSTUTTERChildMedHist_1PctPoverty1_3PctPoverty1_2OlderSibsMatADHDMatLangDelADHDstimulantC5APGARImpVal1PreNatIllDrugPreNatlead_1PreNatFish_1BFMthsCatSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.3.28. BRIEF Parent Rating: Metacognition (lower = better)

HepB: Change in Estimate and Precision as Covariates Are Dropped

BRIEF Parent Rating: Behavior Regulation

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-2 -1 0 1 2

PctPoverty1_3IronDef_1YoungerSibsBFMthsCatOlderSibsPreNatIllDrugMatAgeCatMatSTUTTERMatSpeechDelPreNatFish_1PreNatFillings_1PctPoverty1_2ChildMedHist_1ChildAge3ChildAge2PreNatlead_1C5APGARImpVal1PreNatHomePro_1MatADHDMatLangDelChdPICA_1ADHDstimulantPreNatOrgMerc_1PreNatTuna_1PreNatAlcohol_1PreNatNicotine_1EngOnlyDayCareHomeImpVal1DayCareCentrImpVal1SiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprChdBWT_GrpsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 157

Exhibit D.4.3.29. BRIEF Teacher Rating: Metacognition (lower = better)

HepB: Change in Estimate and Precision as Covariates Are Dropped

BRIEF Teacher Rating: Metacognition (lower=better)

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-2 -1 0 1 2

MatSpeechDelOlderSibsPreNatIllDrugChildAge3PreNatFish_1PctPoverty1_3ChdPICA_1IronDef_1MatLangDelYoungerSibsComputerExprChildMedHist_1MatAgeCatPreNatlead_1PreNatHomePro_1C5APGARImpVal1MatSTUTTERChildAge2DayCareHomeImpVal1PreNatNicotine_1PctPoverty1_2MatADHDADHDstimulantPreNatFillings_1PreNatOrgMerc_1PreNatTuna_1PreNatAlcohol_1BFMthsCatEngOnlyDayCareCentrImpVal1SiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.3.30. CRS-R: Parent Rating: Hyperactive/Impulsive (lower = better)

HepB: Change in Estimate and Precision as Covariates Are Dropped

CRS-R: Parent Rating: Hyperactive/Impulsive

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-0.5 0.0 0.5

MatLangDelChildMedHist_1ChildAge3IronDef_1PreNatFish_1PreNatlead_1ChildAge2PctPoverty1_3MatSpeechDelPreNatIllDrugPreNatFillings_1YoungerSibsC5APGARImpVal1MatSTUTTEREngOnlyPreNatOrgMerc_1PreNatTuna_1ComputerExprMatAgeCatBFMthsCatPreNatAlcohol_1PctPoverty1_2MatADHDChdPICA_1ADHDstimulantPreNatHomePro_1PreNatNicotine_1DayCareHomeImpVal1DayCareCentrImpVal1OlderSibsSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 158

Exhibit D.4.3.31. CRS-R: Teacher Rating: Hyperactive/Impulsive (lower = better)

HepB: Change in Estimate and Precision as Covariates Are Dropped

CRS-R: Teacher Rating: Hyperactive/Impulsive

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-1.0 -0.5 0.0 0.5 1.0

PreNatAlcohol_1ChdPICA_1PreNatFillings_1PreNatHomePro_1PreNatNicotine_1OlderSibsPreNatlead_1MatAgeCatPctPoverty1_3MatSpeechDelMatLangDelMatADHDDayCareHomeImpVal1YoungerSibsMatSTUTTERPreNatFish_1ChildAge3ChildAge2ComputerExprIronDef_1ChildMedHist_1C5APGARImpVal1PctPoverty1_2ADHDstimulantPreNatIllDrugPreNatOrgMerc_1PreNatTuna_1BFMthsCatEngOnlyDayCareCentrImpVal1SiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.3.32. CRS-R: Parent Rating: Inattentive (lower = better)

HepB: Change in Estimate and Precision as Covariates Are Dropped

CRS-R: Parent Rating: Inattentive

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-1.0 -0.5 0.0 0.5 1.0

PreNatHomePro_1MatSTUTTERYoungerSibsPctPoverty1_3PreNatOrgMerc_1BFMthsCatOlderSibsMatSpeechDelMatAgeCatC5APGARImpVal1PreNatlead_1IronDef_1PreNatFillings_1ChildAge3PreNatIllDrugChildMedHist_1ChildAge2EngOnlyDayCareCentrImpVal1MatLangDelPreNatFish_1ChdPICA_1PreNatNicotine_1PreNatAlcohol_1PreNatTuna_1PctPoverty1_2MatADHDDayCareHomeImpVal1ADHDstimulantSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprChdBWT_CatsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 159

Exhibit D.4.3.33. CRS-R: Teacher Rating: Inattentive (lower = better)

HepB: Change in Estimate and Precision as Covariates Are Dropped

CRS-R: Teacher Rating: Inattentive

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-1.0 -0.5 0.0 0.5 1.0

OlderSibsPreNatlead_1PreNatIllDrugPctPoverty1_3MatSpeechDelPreNatFish_1YoungerSibsDayCareHomeImpVal1ChdPICA_1C5APGARImpVal1MatSTUTTEREngOnlyPreNatOrgMerc_1PctPoverty1_2ChildAge3ChildAge2MatAgeCatIronDef_1PreNatAlcohol_1PreNatHomePro_1ChildMedHist_1MatLangDelMatADHDBFMthsCatADHDstimulantPreNatNicotine_1PreNatTuna_1PreNatFillings_1DayCareHomeImpVal1SiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.3.34. BRIEF Parent Rating: Behavior Regulation (lower = better)

HepB: Change in Estimate and Precision as Covariates Are Dropped

BRIEF Parent Rating: Behavior Regulation

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-1.0 -0.5 0.0 0.5 1.0

MatLangDelC5APGARImpVal1MatSTUTTERMatSpeechDelPreNatIllDrugIronDef_1PctPoverty1_3PreNatOrgMerc_1PreNatlead_1MatAgeCatChildAge3YoungerSibsBFMthsCatChildAge2PreNatFish_1PreNatFillings_1ComputerExprEngOnlyPreNatAlcohol_1ChdBWT_GrpChildMedHist_1PreNatTuna_1OlderSibsPreNatHomePro_1DayCareHomeImpVal1PreNatNicotine_1ChdPICA_1PctPoverty1_2DayCareCentrImpVal1ADHDstimulantMatADHDSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1sexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 160

Exhibit D.4.3.35. BRIEF Teacher Rating: Behavior Regulation (lower = better)

HepB: Change in Estimate and Precision as Covariates Are Dropped

BRIEF Teacher Rating: Behavior Regulation

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-1.0 -0.5 0.0 0.5 1.0 1.5

PreNatFillings_1MatLangDelMatAgeCatChildAge3PreNatIllDrugPreNatFish_1PreNatTuna_1IronDef_1MatSpeechDelComputerExprChdPICA_1PreNatOrgMerc_1PreNatHomePro_1MatSTUTTERDayCareHomeImpVal1PreNatNicotine_1ChildAge2C5APGARImpVal1BFMthsCatPreNatAlcohol_1PctPoverty1_3PctPoverty1_2MatADHDADHDstimulantPreNatlead_1EngOnlyDayCareCentrImpVal1YoungerSibsOlderSibsChildMedHist_1SiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.3.36. Motor tics (current): Assessor Rating (lower = better)

HepB: Change in Estimate and Precision as Covariates Are Dropped

Motor tics (current): Assessor Rating

Dropped covariate is shown above model number

Model Number

HepB Coef

5 10 15 20 25

-0.4 -0.2 0.0 0.2 0.4

EngOnlyPreNatHomePro_1DayCareCentrImpVal1PctPoverty1_3PctPoverty1_2DayCareHomeImpVal1MatSTUTTERC5APGARImpVal1PreNatAlcohol_1IronDefPreNatTuna_1PreNatFish_1BFMthsCatcMedicalHist_1ChildAge3ChildAge2ComputerExprHOME_TotalIndexSingleParentMomEducChdBWT_GrpMomIQ1PctPoverty1SiteChildAgesexmale

Final model at dotted line
Abt Associates, Inc. Appendix D 161

Exhibit D.4.3.37. Phonics tics (current): Assessor Rating (lower = better)

HepB: Change in Estimate and Precision as Covariates Are Dropped

Phonics tics (current): Assessor Rating

Dropped covariate is shown above model number

Model Number

HepB Coef

5 10 15 20

-0.4 -0.2 0.0 0.2 0.4

IronDefChildAge3BFMthsCatC5APGARImpVal1DayCareCentrImpVal1ChildAge2ComputerExprChdPICA_1PreNatAlcohol_1PreNatHomePro_1PctPoverty1_3PctPoverty1_2PreNatTuna_1PreNatFish_1DayCareHomeImpVal1ChdBWT_GrpMomIQ1MomEducPctPoverty1HOME_TotalIndexSiteSingleParentsexmaleChildAge

Final model at dotted line

Exhibit D.4.3.38. Motor tics (current): Parent Rating (lower = better)

HepB: Change in Estimate and Precision as Covariates Are Dropped

Motor tics (current): Parent Rating

Dropped covariate is shown above model number

Model Number

HepB Coef

0 5 10 15 20 25 30

-0.6 -0.4 -0.2 0.0 0.2 0.4

ComputerExprPreNatlead_1PreNatFillings_1DayCareHomeImpVal1ChdPICA_1YoungerSibsChildAge3ChildAge2MatSpeechDelOlderSibsPreNatFish_1IronDefC5APGARImpVal1PreNatTuna_1MatADHDEngOnlyPreNatHomePro_1MatSTUTTERPreNatOrgMerc_1DayCareCentrImpVal1PreNatIllDrugPctPoverty1_3PctPoverty1_2PreNatNicotine_1MomIQ1SingleParentHOME_TotalIndexPctPoverty1MomEducSiteChdBWT_GrpsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 162

Exhibit D.4.3.39. Phonics tics (current): Parent Rating (lower = better)

HepB: Change in Estimate and Precision as Covariates Are Dropped

Phonics tics (current): Parent Rating

Dropped covariate is shown above model number

Model Number

HepB Coef

0 5 10 15 20 25 30

-0.4 -0.2 0.0 0.2 0.4

C5APGARImpVal1PreNatFish_1ChdPICA_1MatSTUTTERPreNatFillings_1IronDefChildAge3ChildAge2BFMthsCatPctPoverty1_3PctPoverty1_2PreNatlead_1PreNatAlcohol_1PreNatIllDrugPreNatHomePro_1PreNatTuna_1cMedicalHist_1MatSpeechDelMatADHDPreNatNicotine_1DayCareCentrImpVal1HOME_TotalIndexPctPoverty1MomIQ1SiteSingleParentChdBWT_GrpMomEducsexmaleChildAge

Final model at dotted line

Exhibit D.4.3.40. WASI Verbal IQ

HepB: Change in Estimate and Precision as Covariates Are Dropped

WASI Verbal IQ

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-2.0 -1.5 -1.0 -0.5 0.0 0.5 1.0

ChildMedHist_1PreNatTuna_1PctPoverty1_3ChildAge3PreNatlead_1PreNatFillings_1MatAgeCatMatSpeechDelPctPoverty1_2PreNatNicotine_1DayCareHomeImpVal1PreNatHomePro_1PreNatAlcohol_1PreNatIllDrugIronDef_1MatADHDChildAge2PreNatOrgMerc_1MatLangDelDayCareCentrImpVal1ChdPICA_1MatSTUTTERADHDstimulantEngOnlyPreNatFish_1C5APGARImpVal1YoungerSibsOlderSibsBFMthsCatSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprChdBWT_GrpsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix D 163

Exhibit D.4.3.41. WASI Performance IQ

HepB: Change in Estimate and Precision as Covariates Are Dropped

WASI: Performance IQ

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-1.5 -1.0 -0.5 0.0 0.5 1.0 1.5

PreNatTuna_1ChildMedHist_1PctPoverty1_3ChildAge3PreNatHomePro_1MatSpeechDelMatAgeCatDayCareHomeImpVal1PreNatlead_1PreNatOrgMerc_1MatADHDPreNatFillings_1OlderSibsMatSTUTTERChdPICA_1C5APGARImpVal1PreNatIllDrugMatLangDelPctPoverty1_2ChildAge2PreNatNicotine_1PreNatAlcohol_1IronDef_1DayCareCentrImpVal1ADHDstimulantPreNatFish_1YoungerSibsEngOnlyBFMthsCatSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprChdBWT_GrpsexmaleChildAge

Final model at dotted line

Exhibit D.4.3.42. WASI Full Scale IQ

HepB: Change in Estimate and Precision as Covariates Are Dropped

WASI Full Scale IQ

Dropped covariate is shown above model number

Model Number

HepB Coef

0 10 20 30 40

-2 -1 0 1

PctPoverty1_3PreNatAlcohol_1ChildMedHist_1PreNatTuna_1PreNatIllDrugMatAgeCatChdPICA_1MatSpeechDelPreNatlead_1PreNatHomePro_1PreNatOrgMerc_1PreNatFillings_1MatADHDChildAge3ChildAge2PctPoverty1_2DayCareHomeImpVal1PreNatNicotine_1MatLangDelMatSTUTTERIronDef_1DayCareCentrImpVal1C5APGARImpVal1ADHDstimulantPreNatFish_1EngOnlyYoungerSibsOlderSibsBFMthsCatSiteSingleParentMomEducPctPoverty1HOME_TotalIndexMomIQ1ComputerExprChdBWT_GrpsexmaleChildAge

Final model at dotted line
Abt Associates, Inc. Appendix E 164

5. Appendix E. Post-Analysis Estimates of Power to

Detect Effects

This appendix addresses the following question:

Given the final sample size, sample composition, exposure distribution, and number of variables,

what was the power to detect a small effect for each exposure type (prenatal, birth to seven

months, birth to one month?

Prior to data collection, we had estimated that the study would have approximately 90%

power to detect small effects. We had defined a “small effect” as standardized regression

coefficient equal to 0.1012. This power estimate was calculated using power formulas

provided by Cohen (1988), and using a two sided test and p<0.05 alpha-level criterion,

and assuming models would contain as many as 30 covariates. Using the formulas

provided by Cohen (1988), we obtained the same estimate of approximately 90% power

to detect small effects of either prenatal, cumulative exposures 0 to 7 months, and

cumulative exposures birth to 28 days. In our analysis plan, we had also presented

estimates obtained via simulations, and using exposure distributions that we expected to

obtain in the study. Those simulations produced results that were similar to the simple

formulas provided by Cohen (1988), in that both methods indicated that the study would

be well powered to detect small effects.

After completion of data collection and analyses, we can re-compute power using results

obtained from the analysis to evaluate whether our pre-study projections were on target.

For comparative purposes, we will also present estimates from the Faroe Islands study.

Jacobson (2001) indicated that “five of the eight effects reported in the Faroe Islands

study were exceedingly small”. For the Faroe Island study, we have enough information

to calculate estimates for the eight outcomes discussed in the Jacobson (2001) article. For

each outcome measure, we present the power to detect a small effect, and we present the

minimum detectable standardized effect sizes (MDSES) corresponding to 80% and 90%

power. The MDSES’s are expressed as standardized regression coefficients.

Let 

ˆ

, and )

ˆ s.e.( represent an estimate and standard error of a standardized regression

coefficient. Then the MDSES can be obtained as:

(1) MDSES = )

ˆ

( ) . .( t / 2  t



s e 

For a two-tailed test with alpha equal to 0.05, and 80% power, we have

(2) MDSES = )

ˆ

) (2.8016) . .( ˆ(1.96 0.8416)s.e.(  s e  .

12 Cohen (1988) suggests that a standardized regression coefficient of 0.10 is a small effect, and this is

within the range of effects detected by the Faroe Islands study (0.05 to 0.18, as per Jacobson (2001)).
Abt Associates, Inc. Appendix E 165

For a two-tailed test with alpha equal to 0.05, and 90% power, we have

(3) MDSES = )

ˆ

) (3.2415) . .( ˆ(1.961.2815)s.e.(  s e  .

In order to perform the calculations for the Faroe Islands data, we need to obtain the

values of )

ˆ s.e.( for each outcome measure. Combining the information presented in

Grandjean et. al., (1997), Budtz-Jorgensen et. al, (2007), and Jacobson (2001) we have

enough information to calculate )

ˆ s.e.( for each of 8 outcome measures. From Grandjean

et. al., (1997), we have the number of non-missing observations used in the analyses for

each outcome, and the p-value corresponding to the effect estimate. From Jacobson

(2001), we have exposure and endpoint standard deviations, and conversion to

standardized regression coefficients for 8 outcome measures. From Budtz-Jorgensen et.

al, (2001), we know that 20 covariates were tested for inclusion in each model and that,

for at least one outcome the final model included 12 of the 20 covariates. Given a pvalue and the degrees of freedom, one can obtain the corresponding t-value by use of

tables or computerized functions. We used the qt() function in Splus version 7.0. Given a

t-value and the value of the standardized regression coefficient, one can solve the formula

(4)

)

ˆ

. .(

ˆ





s e

t 

to obtain

(5)

t

abs

s e

)

ˆ

(

)

ˆ

. .(



  , where )

ˆ abs( is the absolute value of ˆ

.

The power to detect a small effect is obtained by setting MDSES in eq (1) to 0.10, and

solving for t , i.e.,

(6) 1.96

)

ˆ

. .(

0.10

)

ˆ

. .(

  / 2  

 

 

s e

t

s e

MDSES

t

Exhibit E.1 shows the resulting MDSES’s corresponding to 80% and 90% power. For

example, for the Finger Tapping outcome, the Faroe Islands study had 80% power to

detect an effect of size 0.100 or larger and 90% power to detect an effect of size 0.116 or

larger. The last column of the exhibit shows the power to detect a small effect size (i.e.

standardized regression coefficient = 0.10). For the Finger Tapping outcome, the study

had 80 percent power to detect a small effect.

For the eight outcomes shown and 80 percent power, MDSES’s ranged from 0.071 to

0.152. For 90% power MDSES’s range from 0.083 to 0.176. The power detect a small

effect ranged from 45 to 98 percent.
Abt Associates, Inc. Appendix E 166

Exhibit E.2 shows power estimates from the Study of Prenatal and Infant Exposure to

Thimerosal and Neuropsychological Outcomes at Ages 7 to 10 Years. The power to

detect small effects was at 0.79 or above for all outcomes except for teacher rated

measures of behavior regulation attention/executive functioning. The sample sizes were

lower for those measures due to non-response of teachers. For the teacher rated measures

the power to detect small effects was as low as 67 percent for birth to 7 month exposures.

The power was well over 80 percent for all but a few of the remaining outcomes, and the

power to detect small effects was well over 90 percent for the majority of effects.

The MDSES’s ranged from 0.056 to 0.117 for 80% power and from 0.65 to 0.135 for

90% power.

This analysis indicates the power of the current study was in good agreement with what

had been projected during the design phase. Furthermore, the current study tended to

have greater power to detect small effects than the Faroe Islands study, as was expected

since the current study had a larger sample size and a more comprehensive set of

covariates.
Abt Associates, Inc. Appendix E 167

Exhibit E.1: For Eight Outcome Measures From Faroe Islands Study

Estimated Minimum Detectable Standardized Effect Sizes (MDSES) for 80% and 90% Power

And

Power to Detect Effect Size of 0.10

Values Provided in Published Articles Calculated Values

Outcome StdCoefa



ˆ

N

b Number

of

Covariate

s

c

p-valueb Std Err



ˆ

MDSES

80%

Power

MDSES

90%

Power

Power to

Detect

Effect

Size 0.10

Finger

Tapping

-0.07 901 12 0.05 0.036 0.100 0.116 0.80

CPT:

errors

0.08 431 12 0.02 0.034 0.096 0.111 0.83

CPT:

reaction

time

0.18 428 12 0.001 0.054 0.152 0.176 0.45

Digit span -0.06 889 12 0.05 0.031 0.086 0.099 0.90

Boston

Naming:

no cues

-0.12 866 12 0.0003 0.033 0.093 0.107 0.86

Boston

Naming:

cues

-0.13 865 12 0.0001 0.033 0.093 0.108 0.85

CVLT:

short-term

recall

-0.06 867 12 0.02 0.026 0.072 0.083 0.97

CVLT:

long-term

recall

-0.05 837 12 0.05 0.025 0.071 0.083 0.98

a From Jacobson (2001); b from Grandjean et. al 1997; c from Budtz-Jorgensen et. al (2001), exact number

of covariates for each outcome unknown, but this article shows that 20 were considered and 12 were used

in model for at least one outcome measure.
Abt Associates, Inc. Appendix E 168

Exhibit E.2: Current Study

Estimated Minimum Detectable Standardized Effect Sizes (MDSES) for 80% and 90% Power

And

Power to Detect Effect Size of 0.10

PreNatThimer HepB

(Exposure Birth to 28 Days)

Exp07mos

(Exposure Birth to 7 Months)

Std

Err



ˆ

MDSES

80%

Power

MDSES

90%

Power

Power

to

Detect

Effect

Size

0.10

Std

Err



ˆ

MDSES

80%

Power

MDSES

90%

Power

Power

to

Detect

Effect

Size

0.10

Std

Err



ˆ

MDSES

80%

Power

MDSES

90%

Power

Power

to

Detect

Effect

Size

0.10

Boston Naming Test 0.022 0.061 0.071 1.00 0.023 0.065 0.075 0.99 0.027 0.075 0.086 0.96

NEPSY: Speeded

Naming

0.028 0.078 0.090 0.95 0.028 0.080 0.092 0.94 0.033 0.093 0.108 0.85

NEPSY:

Comprehension of

Instructions

0.030 0.083 0.096 0.92 0.029 0.082 0.095 0.93 0.033 0.092 0.107 0.86

CELF: Formulated

Sentences

0.026 0.073 0.084 0.97 0.027 0.075 0.087 0.96 0.032 0.089 0.103 0.88

CELF: Recalling

Sentences

0.026 0.072 0.083 0.97 0.026 0.074 0.085 0.97 0.030 0.085 0.098 0.91

GFTA: Articulation 0.031 0.086 0.099 0.90 0.030 0.084 0.097 0.92 0.034 0.094 0.109 0.84

CVLT-C: Free Recall,

No Delay

0.028 0.079 0.092 0.94 0.029 0.081 0.094 0.93 0.034 0.094 0.109 0.84

CVLT-C: Free Recall,

Short Delay

0.028 0.078 0.090 0.95 0.030 0.083 0.096 0.92 0.034 0.096 0.111 0.83

CVLT-C: Cued Recall,

Short Delay

0.028 0.078 0.090 0.95 0.028 0.080 0.092 0.94 0.033 0.091 0.105 0.87

CVLT-C: Free Recall,

Long Delay

0.030 0.084 0.097 0.92 0.030 0.083 0.096 0.92 0.034 0.095 0.110 0.83

CVLT-C: Cued Recall,

Long Delay

0.027 0.074 0.086 0.96 0.029 0.081 0.094 0.93 0.034 0.095 0.110 0.83

CMS Stories 1:

Immediate Recall

0.022 0.063 0.073 0.99 0.023 0.065 0.075 0.99 0.027 0.076 0.088 0.96

CMS Stories 2:

Delayed Recall

0.023 0.063 0.073 0.99 0.023 0.066 0.076 0.99 0.027 0.076 0.088 0.96

WJIII: Letter- Word

Identification

0.023 0.064 0.074 0.99 0.024 0.066 0.077 0.99 0.028 0.078 0.091 0.95

Grooved Pegboard:

Dominant Hand

0.019 0.054 0.063 1.00 0.020 0.056 0.064 1.00 0.023 0.064 0.074 0.99

Grooved Pegboard:

Non-dom Hand

0.020 0.056 0.065 1.00 0.021 0.058 0.067 1.00 0.024 0.068 0.078 0.99

Finger Tapping:

Dominant Hand

0.027 0.075 0.087 0.96 0.028 0.077 0.090 0.95 0.032 0.091 0.105 0.87

Finger Tapping: Nondominant Hand0.026 0.074 0.085 0.97 0.027 0.075 0.087 0.96 0.032 0.088 0.102 0.89

Stanford Binet:

Copying

0.030 0.085 0.099 0.91 0.030 0.085 0.099 0.91 0.036 0.099 0.115 0.80

GDS Vigilance Task:

Correct Responses

0.029 0.080 0.093 0.94 0.030 0.084 0.097 0.92 0.034 0.096 0.111 0.83

GDS Vigilance Task:

Errors

0.029 0.082 0.095 0.93 0.030 0.084 0.097 0.92 0.035 0.099 0.114 0.81

WISC III: Digit Span,

Forward Recall

0.031 0.086 0.099 0.90 0.030 0.084 0.097 0.92 0.034 0.094 0.109 0.84

WISC III: Digit Span,

Backward Recall

0.031 0.087 0.101 0.89 0.031 0.086 0.100 0.90 0.036 0.099 0.115 0.80

WISC III: Digit Span,

Combined

0.028 0.078 0.090 0.95 0.030 0.083 0.096 0.92 0.033 0.093 0.107 0.85

BRIEF Parent Rating:

Metacognition

0.030 0.083 0.096 0.92 0.031 0.086 0.100 0.90 0.036 0.099 0.115 0.80

BRIEF Teacher

Rating: Metacognition

0.032 0.091 0.105 0.87 0.034 0.096 0.111 0.83 0.041 0.115 0.133 0.68

CRS-R: Parent Rating:

Hyperactive/Impulsive

0.029 0.082 0.095 0.93 0.031 0.088 0.101 0.89 0.036 0.101 0.117 0.79

CRS-R: Teacher

Rating:

0.031 0.088 0.102 0.89 0.034 0.095 0.110 0.84 0.040 0.113 0.131 0.70
Abt Associates, Inc. Appendix E 169

Exhibit E.2: Current Study

Estimated Minimum Detectable Standardized Effect Sizes (MDSES) for 80% and 90% Power

And

Power to Detect Effect Size of 0.10

PreNatThimer HepB

(Exposure Birth to 28 Days)

Exp07mos

(Exposure Birth to 7 Months)

Std

Err



ˆ

MDSES

80%

Power

MDSES

90%

Power

Power

to

Detect

Effect

Size

0.10

Std

Err



ˆ

MDSES

80%

Power

MDSES

90%

Power

Power

to

Detect

Effect

Size

0.10

Std

Err



ˆ

MDSES

80%

Power

MDSES

90%

Power

Power

to

Detect

Effect

Size

0.10

Hyperactive/Impulsive

CRS-R: Parent Rating:

Inattentive

0.030 0.083 0.096 0.92 0.031 0.087 0.100 0.90 0.036 0.101 0.117 0.79

CRS-R: Teacher

Rating: Inattentive

0.031 0.088 0.102 0.89 0.034 0.096 0.111 0.83 0.041 0.116 0.134 0.68

BRIEF Parent Rating:

Behavior Regulation

0.030 0.085 0.099 0.91 0.031 0.087 0.101 0.89 0.036 0.100 0.116 0.80

BRIEF Teacher

Rating: Behavior

Regulation

0.033 0.092 0.107 0.86 0.035 0.097 0.112 0.82 0.042 0.117 0.135 0.67

WASI Verbal IQ 0.027 0.075 0.087 0.96 0.027 0.077 0.089 0.96 0.032 0.089 0.102 0.89

WASI Performance IQ 0.029 0.082 0.095 0.93 0.030 0.084 0.097 0.92 0.034 0.095 0.110 0.84

WASI Full Scale IQ 0.027 0.076 0.088 0.96 0.028 0.078 0.091 0.95 0.033 0.091 0.106 0.87
Abt Associates, Inc. Appendix E 170

References:

Bollen, K.A., Jackman, R. W., (1990). Regression Diagnostics: An Expository Treatment

of Outliers and Influential Cases, in Fox J., and Long J.S., eds (1990) Modern

Methods of Data Analysis Newbury Park CA: Sage

Budtz-Jorgensen, E., Keiding, N., Grandjean, P, Weihe, P., White, R. F., (2007).

Confounder identification in environmental epidemiology. Assessment of health

Effects of Prenatal mercury exposure. Annal of Epidemiology; 17:27-35.

Grandjean P, , Weihe, P., White, R. F., Debes, F, Araki, S. Yokoyama, K. Murata, K.

Sorensen, N, Dahl, R, Jorgensen, P. J. : Cognitive deficit in 7-year-old children

with prenatal exposure to methylmercury. Neurotoxicology and Teratology. Vol

19, no 6, 417-428.

Jacobson, J. L., (2001). Contending with contradictory data in a risk assessment context:

The case of methlymercury. Neurotoxicology 22, pp 667-675.