Support Documents for 

Significant New Use Rule (SNUR) on 

Premanufacture Notice (PMN) 

P-12-260 

EPA Docket EPA-HQ-OPPT-2012-0450 

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Index 

A-001 Structure Activity Team (SAT) Report for 

 PMN P-12-260 

A-002 Initial Review Engineering Report for 

 PMN P-12-260 

A-003 Initial Review Exposure Report for 

 PMN P-12-260 

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A-001 

Structure Activity Team (SAT) Report 

for PMN P-12-260 

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SAT Report

PMN Number: P-12-0260

SAT Date: 4/17/2012

Print Date: 5/2/2012

Related cases:

Health related cases: 

Ecotox related cases: 

Concern levels:

Type of Concern: Health Eco Comments

Level of Concern: 1-2 3

 Persistence Bioaccum Toxicity Comments

1 11

Exposure Based Review:

Health: No

Ecotox: No

Routes of exposure: Health: Dermal Inhalation 

Ecotox: All releases to water

Fate: ;

Keywords:

 Keywords: LIVER, AQUATOX-A,C

Summary of Assessment:

 Fate:

Fate Summary: P-12-0260

FATE: Estimations for typical 

Liquid with MP < 25 C (E)

log Kow = 5.04 (E) 

S = 7.41 mg/L at 25 C (E)

VP = 5.9E-5 torr at 25 C (E)

BP = 313 C (E)

H = 2.87E-6 (E)

log Koc = 2.83 (E)

log Fish BCF = 1.62 (E)

log Fish BAF = 2.48 (E) 

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POTW removal (%) = 90 via sorption and biodeg

Time for complete ultimate aerobic biodeg = wk

Sorption to soils/sediments = moderate

Volatilization half-life from a standard river = 500 hrs

Volatilization half-life from a standard lake = 160 da

Atmospheric Oxidation Half-life = 9.0 hr via OH radical

PBT Potential: P1B1

*CEB FATE: Migration to ground water = slow

 Health:

 Health Summary: Absorption is poor all routes based on analogs. There is 

concern for liver effects based on the bromo substituent. Low moderate concern

 Ecotox:

Test Organism Test 

Type

Test End 

Point

Predicted Measured Comments

fish 96-h LC50 1.4

daphnid 48-h LC50 0.36

green algal 96-h EC50 0.36

fish _ chronic value 0.026

daphnid _ chronic 

value

0.047

algal _ chronic 

value

0.36

Sewage Sludge 3-h EC50 _

Sewage Sludge _ Chronic 

Value

_

Ecotox Values Comments: Predictions are based on SARs for halo-alcohols; SAR chemical 

class = halo-alcohol; MW 307; log Kow 3.33 (EPI); mp = 203 C (M); S = 0.57 g/L (P); 

effective concentrations based on 100% active ingredients and mean measured concentrations; 

hardness <150.0 mg/L as CaCO3; and TOC <2.0 mg/L;

Factors Values Comments

Assessment Factor 10

Concentration of Concern 

(ppb)

3

SARs halo-alcohols

SAR Class halo-alcohol

Ecotox Category None

Ecotox Factors Comments: 

 SAT Chair: Becky Jones

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A-002 

Initial Review Engineering Report 

for PMN P-12-260 

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INITIAL REVIEW ENGINEERING REPORT 

PMN: 12-0260

Focus Ready Draft 4/23/2012

ENGINEER: Austin \ DDH

PV (kg/yr): 

SUBMITTER: 

USE:

OTHER USES: 

MSDS: No Label: No

TLV/PEL:

MSDS not provided

CRSS (04/16/2012):

Consumer Use: 

SAT (concerns) (04/17/2012):

Migration to groundwater: Slow

PBT rating: P1B1T1

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Health: 1-2 Dermal, Inhalation

Eco: 3 Water (All releases to water with a CC = 3 ppb)

OCCUPATIONAL EXPOSURE RATING: 1A

NOTES & KEY ASSUMPTIONS:

Generated by the 06/07/2005 version of ChemSTEER. 

POLLUTION PREVENTION CONSIDERATIONS:

EXPOSURE-BASED REVIEW: 

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INITIAL REVIEW ENGINEERING REPORT 

PMN: 12-0260

ENVIRONMENTAL RELEASES ESTIMATE SUMMARY

IRER Note: The daily releases listed for any source below

may coincide with daily releases from the other sources

to the same medium. 

OCCUPATIONAL EXPOSURES ESTIMATE SUMMARY

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INITIAL REVIEW ENGINEERING REPORT 

PMN: 12-0260

ENVIRONMENTAL RELEASES ESTIMATE SUMMARY

IRER Note: The daily releases listed for any source below

may coincide with daily releases from the other sources

to the same medium. 

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OCCUPATIONAL EXPOSURES ESTIMATE SUMMARY

MEMORANDUM of CBI TELEPHONE CONVERSATION

CALL BY: Daryl Hudson

Organization: ERG for CEB/OPPT

CALL TO: 

Organization: 

Date: 04/18/2012

Time: 10:30 AM

Phone: 

PMN: 12-0260

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A-003 

Initial Review Exposure Report 

 for PMN P-12-260 

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Page 1 of 1 

 

POST FOCUS EXPOSURE REPORT 

Release information for this compound does not meet criteria for preparation of an exposure assessment; 

were eliminated and the were below the threshold for exposure 

assessment 

Assessor: 

 

ENVIRONMENTAL RELEASES 

Scenario#: Number of Release Sites: 

Release Activity: 

Release Description: WATER LANDFILL INCINER LAND/INCIN FUGITIVE 

Total Releases: 

 

(kg/yr) (kg/yr) (kg/yr) (kg/yr) (kg/yr) 

Release Days/yr: 

 

Per Site Release: 

(kg/day) (kg/yr) (kg/yr) (kg/yr) (kg/day) 

Remarks: EAB DROP: Release information for this compound does not meet criteria for preparation 

of an exposure assessment in the Exposure Assessment Branch=s (EAB) Initial Review 

Exposure Report (this report). 

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