Appendix B

Appendix B-11 

B

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Latex in Vaccine Packaging 

“Immediate-type allergic reactions due to latex allergy have been described after vaccination, but such reactions 

are rare. If a person reports a severe anaphylactic allergy to latex, vaccines supplied in vials or syringes that 

contain natural rubber latex should be avoided if possible. If not, if the decision is made to vaccinate, providers 

should be prepared to treat immediate allergic reactions due to latex, including anaphylaxis. The most common 

type of latex hypersensitivity is a delayed-type (type 4, cell-mediated) allergic contact dermatitis. For patients with 

a history of contact allergy to latex, vaccines supplied in vials or syringes that contain dry natural rubber or natural 

rubber latex may be administered.” 

(ACIP General Best Practice Guidelines for Immunization) 

Vaccine (Trade Name) Package Insert Date Latex (Yes/No)(a) 

Adenovirus 10/2019 No 

Anthrax (Biothrax) 11/2015 Yes 

BCG (Tice) 02/2009 No 

Cholera (Vaxchora) 06/2016 No 

Dengue (Dengvaxia) 06/2019 No 

DT (Sanofi) 06/2018 No 

DTaP (Daptacel) 01/2021(b) No 

DTaP (Infanrix) 01/2021(b) Yes – Syringe, No – Vial 

DTaP-IPV (Kinrix) 01/2021(b) Yes – Syringe, No – Vial 

DTaP-IPV (Quadracel) 02/2021 No 

DTaP-HepB-IPV (Pediarix) 01/2021(b) Yes 

DTaP-IPV/Hib (Pentacel) 12/2019 No 

DTaP-IPV-Hib-HepB (Vaxelis) 10/2020 No 

Ebola Zaire (ERVEBO) 01/2021(b) No 

Hib (ActHIB) 05/2019 No 

Hib (Hiberix) 04/2018 No 

Hib (PedvaxHIB) 01/2021(b) Yes 

Hep A (Havrix) 01/2021(b) Yes – Syringe , No – Vial 

Hep A (Vaqta) 01/2021(b) Yes – Syringe, Yes – Vial 

Hep B (Engerix-B) 01/2021(b) Yes – Syringe, No – Vial 

Hep B (Recombivax) 12/2018 Yes – Syringe, Yes – Vial 

Hep B (Heplisav-B) 05/2020 No 

Hep A/Hep B (Twinrix) 01/2021(b) Yes 

HPV (Gardasil 9) 08/2020 No 

Influenza (Afluria) Quadrivalent(c) 03/2021 No 

Influenza (Fluad) Quadrivalent(c) 03/2021 No 

Influenza (Fluarix) Quadrivalent(c) 2021 No 

Influenza (Flublok) Quadrivalent(c) 03/2021 No 

Influenza (Flucelvax) Quadrivalent(c) 10/2021(b) No 

Influenza (Flulaval) Quadrivalent(c) 2021 No 

Influenza (Fluzone) Quadrivalent(c) 2021 No 

Influenza (Fluzone) High Dose(c) 2021 No 

Influenza (FluMist) Quadrivalent(c) 08/2021 No 

IPV (Ipol) 01/2021(b) No 

Appendix B_Web.indd 11 11/1/2021 10:27:00 AM 
Appendix B-12 

Appendix B

B

Appendix B_Web.indd 12 Appendix B_Web.indd 12 11/1/2021 10:27:00 AM 11/1/2021 10:27:00 AM 

Vaccine (Trade Name) Package Insert Date Latex (Yes/No)(a) 

Japanese Encephalitis (Ixiaro) 09/2018 No 

MenACWY (Menactra) 04/2018 No 

MenACWY(MenQuadfi) 01/2021(b) No 

MenACWY (Menveo) 07/2020 No 

MenB (Bexsero) 01/2021(b) Yes 

MenB (Trumenba) 2018 No 

MMR (M-M-R II) 12/2020 No 

MMRV (ProQuad) (Frozen: Recombinant Albumin) 01/2021(b) No 

PCV13 (Prevnar 13) 08/2017 No 

PPSV-23 (Pneumovax) 09/2020 No 

Rabies (Imovax) 10/2019 No 

Rabies (RabAvert) 2018 No 

Rotavirus (RotaTeq) 01/2021(b) No 

Rotavirus (Rotarix) 01/2021(b) Yes 

Smallpox (Vaccinia) (ACAM2000) 03/2018 No 

Td (Tenivac) 11/2019 Yes – Syringe, No – Vial 

Td (TDVAX) 09/2018 No 

Tdap (Adacel) 12/2020 Yes(d) – Syringe, No – Vial 

Tdap (Boostrix) 09/2020 Yes – Syringe, No – Vial 

Typhoid (Typhim Vi) 03/2020 No 

Typhoid (Vivotif Ty21a) 09/2013 No 

Varicella (Varivax) Frozen 01/2021(b) No 

Yellow Fever (YF-Vax) 02/2019 No 

Zoster (Shingles) (Shingrix) 01/2021(b) No 

Abbreviations: DT = diphtheria and tetanus toxoids; DTaP = diphtheria and tetanus toxoids and acellular pertussis; Hep A = Hepatitis A; Hep B = Hepatitis B; Hib 

= Haemophilus infuenzae type b; HPV = human papillomavirus; IPV = inactivated poliovirus; LAIV = live, attenuated infuenza vaccine; MenACWY = quadrivalent 

meningococcal conjugate vaccine; MenB = serogroup B meningococcal vaccine; MMR = measles, mumps, and rubella; MMRV = measles, mumps, rubella, varicella; 

PCV13 = pneumococcal conjugate vaccine; PI = Package Insert; PPSV23= pneumococcal polysaccharide vaccine; Td = tetanus and diphtheria toxoids; Tdap = tetanus 

toxoid, reduced diphtheria toxoid, and acellular pertussis.

 (a)All information was extracted from manufacturers’ package inserts. The date shown in the Date column of the table is the edition date of the PI is use in 

February 2020. If in doubt about whether a PI has been updated since this table was prepared, check the FDA’s website at: 

http://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm093833.htm 

(b)The PI was not dated and this is the date the PI was reviewed for this table. 

(c) All infuenza vaccine in this table are 2021-2022 northern hemisphere formulation. 

(d)The most current PI (12/2020) indicates no latex in any presentation of Adacel. Previous PIs indicate tip caps of some lots of Adacel preflled syringes contain latex 

while others do not. Check the package insert that came with your vaccine, if necessary. 

November 2021