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Dear Colleague Letters										Related Pages
					Return to Main MenuLaunch of the Tuberculosis Epidemiologic Studies Consortium (TBESC) III for the 2021–2026 Cycle
October 15, 2021
Dear Colleagues:
The Centers for Disease Control and Prevention is pleased to announce the launch of the Tuberculosis (TB) Epidemiologic Studies Consortium (TBESC) III for the 2021–2026 cycle. TBESC is a CDC-funded initiative to carry out observational epidemiologic research and related studies to improve identification, diagnosis, prevention, and control of TB disease and latent TB infection. TBESC is one of CDC’s flagship TB research consortia tasked with identifying approaches to accelerate TB elimination in the United States.
TBESC was established in 2001, with the first research cycle ending in 2011. TBESC-I conducted 29 studies via funding awarded to 22 sites and focused on studies ranging from the molecular epidemiology of multidrug-resistant TB disease to the cost of treating TB disease in urban health departments. The second TBESC research cycle began in 2011 and concluded in September 2021. Via funding awarded to 10 sites, TBESC-II conducted three significantly larger main studies focused on evaluating TB blood and skin tests, describing the latent TB infection care cascade, and identifying latent TB infection care cascade gaps, barriers, and facilitators. The primary study, one of the largest of its kind, compared the ability of the tuberculin skin test and interferon-gamma release assay to predict progression from latent TB infection to TB disease. Over the last two decades, TBESC studies have provided insight into how to improve public health programs’ capacity for preventing TB.
TBESC-III launched at the end of September 2021 and will lead to a better understanding of how TB infection screening, testing, and treatment is offered to patients in primary care settings, as well as the effectiveness and efficiency of potential public health interventions to increase the number of eligible patients who complete latent TB infection treatment. Epidemiologic modeling has demonstrated that the main driver of U.S. TB incidence is no longer recent transmission from infectious TB patients in the United States, but rather the large number of individuals (estimated as up to 13 million people) with latent TB infection who live in the United States but often acquired their TB infection elsewhere. TBESC-III researchers will:
Identify primary care settings that serve non-U.S.–born persons at elevated risk for TB infection,
Collect retrospective and prospective electronic medical record data,
Design and implement primary-care–based interventions to improve performance measures across the latent TB infection care cascade, and
Monitor and evaluate intervention performance over time to identify efficient and effective strategies to prevent TB disease.The four organizations awarded contracts to conduct TBESC-III research are:
Denver Health and Hospital Authority – Principal Investigator (PI): Robert Belknap, MD;
Kaiser Foundation Research Institute – PI: Jacek Skarbinski, MD;
Public Health – Seattle & King County – PI: Masa Narita, MD; and
The Regents of the University of California, San Francisco – PI: Priya Shete, MD, MPH.We look forward to working with the selected TBESC-III participants over the next 5 years to build upon the previous 20 years of TBESC research, as we continue to strive to eliminate TB in the United States.

Sincerely,
**Philip LoBue, MD, FACP, FCCP**
Director
Division of Tuberculosis Elimination
National Center for HIV, Viral Hepatitis, STD, and TB Prevention
							
					
						Page last reviewed:  October 18, 2021					Content source: 	Division of Tuberculosis Elimination, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention homeTuberculosisBasic TB Factsplus iconHow TB SpreadsLatent TB Infection and TB DiseaseSigns & SymptomsTB Risk FactorsExposure to TBTB PreventionVaccinesTB & HIV CoinfectionTB and DiabetesTB TermsPersonal StoriesTesting & Diagnosisplus iconWho Should be TestedTesting for TB InfectionTesting in BCG-Vaccinated PersonsTB Screening and Testing of Health Care PersonnelTesting During PregnancyDiagnosing latent TB infection and TB diseaseTreatmentplus iconDeciding When to Treat Latent TB InfectionTreatment Regimens for Latent TB Infection (LTBI)Treatment for TB DiseaseAdverse EventsTB Treatment of Persons Living with HIVTB Treatment and PregnancyTB Treatment for ChildrenFrequently Asked QuestionsDrug-Resistant TBResearchplus iconTB Epidemiologic Studies Consortiumplus iconResearch ProjectsPublicationsTB Trials Consortiumplus iconStudy DescriptionsBackgroundBehavioral & Social Science ResearchHealth Care Settingsplus iconTB Infection Control in Health Care SettingsResources for TB Screening and Testing of Health Care Personnelplus iconFrequently Asked QuestionsTB in Specific Populationsplus iconHealth DisparitiesAsian PersonsBlack or African American PersonsHispanic or Latino PersonsChildrenPregnancyCorrectional FacilitiesPeople Experiencing HomelessnessInternational TravelersLaboratory Informationplus iconDrug Susceptibility TestingFalse-Positive Investigation ToolkitInterim Laboratory Biosafety Guidance for XDR  tuberculosis strainsModel Performance Evaluation Program (MPEP)Rapid Molecular Testing to Detect Drug-Resistant TB in the USplus iconExecutive SummaryIntroductionBackground on Tests for Molecular Detection of DRGeneral Considerations and Principles for a Molecular DR Testing ServicePossible Scenarios and Scope of Testing for a Molecular DR Testing ServiceResearch NeedsGeneral Recommendations of the Expert PanelCommunication Plan for the ReportRecommendationsReferencesPanel Members and CDC ParticipantsAppendix 1Appendix 2Appendix 3The Uses of Nucleic Acid Amplification Tests for the Diagnosis of TBplus iconGeneral ConsiderationsGeneral Recommendations of the Expert PanelRecommendations to ACET, CDC, DTBEData & Statisticsplus iconTB Incidence in the United StatesReported TB in the US, 2022 Surveillance Reportplus iconNational DataReporting Area DataRisk FactorsDemographicsTB Treatment and Case OutcomesDrug-Resistant TBMolecular SurveillanceTuberculosis in the United States, 2022 (Slide Set)Archived Surveillance Reports and Slide Sets2021 State and City ReportArchived State and City ReportsProfessional Resources & Toolsplus iconTools for Healthcare ProvidersResources for TB Programsplus iconStrengthening Civil Surgeons’ Capacity to Improve LTBI Surveillance and Outcomes Among Status AdjustersNotice of Funding Opportunity (NOFO)Program EvaluationTB Centers of ExcellenceTB Elimination AllianceTB Genotypingplus iconConventional TB GenotypingWhole Genome SequencingTB GIMSAnalytic ToolsLatent Tuberculosis Infection ResourcesPublications & Productsplus iconPatient and Public MaterialsFact SheetsGuidelinesplus iconControl & EliminationDrug-Resistant TBInfection Control & PreventionLaboratory & GenotypingTB & HIVTB in Specific PopulationsTesting & DiagnosisTreatmentVaccines & ImmunizationsArchived TB GuidelinesGuides & Toolkitsplus iconAggregate ReportsCDC TB Surveillance TrainingCore CurriculumEffective TB Interviewing for Contact InvestigationEthnographic GuidesFalse-Positive Investigation ToolkitForging Partnerships to Eliminate TuberculosisGuide to Application of GenotypingLTBI: A Guide for Primary Health Care ProvidersMantoux Tuberculin Skin Testing ProductsReport of Verified Case of Tuberculosis (RVCT)Self-Study ModulesTB Contact Investigation Interviewing Skills CourseTB eDOT ToolkitUnderstanding the TB Cohort Review ProcessNewslettersplus iconTB Notes, No. 4, 2023TB Notes, No. 3, 2023TB Notes. No. 2, 2023TB Notes. No. 1, 2023TB Notes, No. 4, 2022TB Notes, No. 3, 2022TB Notes, No. 2, 2022TB Notes, No. 1, 2022TB Notes, No. 4, 2021TB Notes, No. 3, 2021TB Notes, No. 2, 2021TB Notes, No. 1, 2021Pamphlets, Brochures, Bookletsplus iconQuestions and AnswersPatient Education SeriesTuberculosis - Get the FactsTuberculosis - The Connection between TB and HIV12-Dose Regimen for Latent TB Infection-Patient Education BrochurePostersplus iconMantoux Tuberculin Skin Test Wall ChartWorld TB DayThink TBStop TBTake on TBReports & Articlesplus iconDTBE Authored Journal ArticlesTuberculosis Laboratory Aggregate ReportsSlide Setsplus iconIntroduction to TuberculosisEpidemiology of Tuberculosis Among Non-U.S.​–Born Persons in the United States, 1993–2016Self-Study Modules on Tuberculosis, 1-5 Slide SetsThe Tuberculosis (TB) in Correctional Settingsplus iconFacilitator GuideIntroduction to TB GenotypingEpidemiology of Tuberculosis in Correctional Facilities, United States, 1993-2017Prevention and Control of Tuberculosis in Correctional and Detention FacilitiesGuidelines for Preventing the Transmission of M. TB in Health care SettingsInvestigation of Contacts of Persons with Infectious TBEpidemiology of Pediatric Tuberculosis in the United StatesTargeted Tuberculosis Testing and Treatment of Latent Tuberculosis InfectionElectronic Tools & ResourcesWeb-Based Courses & Webinarsplus iconTB 101 for Health Care WorkersContent SyndicationInfographicsplus iconSocial Media GraphicsCustomizable Take on TB Infographic with InstructionsEventsWorld TB Dayplus iconU.S. TB ChampionsHistoryFeaturesplus iconTB Risk FactorsTreating Latent TB Infection with Short-Course RegimensWorld Tuberculosis (TB) Day 2021World Tuberculosis (TB) Day 2020Linksplus iconState TB Control OfficesAbout Usplus iconMission Statement and Activitiesplus iconDTBE Strategic PlanNational TB Program ObjectivesOrganization ChartAdvisory Groupsplus iconFederal TB Task Force To receive email updates about this page, enter your email address: Email Address			What's this?				Submit


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