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Sexually Transmitted Infections Treatment Guidelines, 2021


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Table 7 – STI Treatment Guidelines										Related Pages
					Guidelines for postexposure prophylaxis* of persons with nonoccupational exposure†to blood or body fluids that contain blood, by exposure type and hepatitis B vaccination status
Table 7
Source of exposure
Unvaccinated person§
Previously vaccinated person¶**HBsAg-positive source**Percutaneous (e.g., bite or needlestick) or mucosal exposure to HBsAg-positive blood or body fluids***or***Sex or needle-sharing contact with an HBsAg-positive person***or***Victim of sexual assault or abuse by an assailant who is HBsAg positive
Administer hepatitis B vaccine series and HBIG
Complete hepatitis B vaccine series and HBIG, if vaccine series not completed***or***Administer hepatitis B vaccine booster dose, if previous vaccination without testing****Source with unknown HBsAg status**Percutaneous (e.g., bite or needlestick) or mucosal exposure to potentially infectious blood or body fluids from a source with unknown HBsAg status***or***Sex or needle-sharing contact with person with unknown HBsAg status***or***Victim of sexual assault or abuse by a perpetrator with unknown HBsAg status
Administer hepatitis B vaccine series
Complete hepatitis B vaccine seriesSources: CDC. CDC guidance for evaluating health-care personnel for hepatitis B virus protection and for administering postexposure management. MMWR Recomm Rep 2013;62(No. RR-10); CDC. Postexposure prophylaxis to prevent hepatitis B virus infection. MMWR Recomm Rep 2006;55(No. RR-16).
Abbreviations: HBIG = hepatitis B immune globulin; HBsAg = hepatitis B surface antigen.
* When indicated, immunoprophylaxis should be initiated as soon as possible, preferably within 24 hours. Studies are limited regarding the maximum interval after exposure during which postexposure prophylaxis is effective, but the interval is unlikely to exceed 7 days for percutaneous exposures or 14 days for sexual exposures. The hepatitis B vaccine series should be completed. These guidelines apply to nonoccupational exposures.
†These guidelines apply to nonoccupational exposures.
§A person who is in the process of being vaccinated but who has not completed the vaccine series should complete the series and receive treatment for hepatitis B as indicated.
¶A person who has written documentation of a complete hepatitis B vaccine series and who did not receive postvaccination testing.
** No booster dose is needed for persons who have written documentation of hepatitis B vaccine series with serologic response.
							
					
						Page last reviewed:  July 22, 2021					Content source: 	Division of STD Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention homeSTI Treatment Guidelines, 2021
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