Operational Protocol for U.S.-Mexico 

Binational Communication and 

Coordination on Disease 

Notifications and Outbreaks

U.S.-Mexico Binational Technical Work Group* 

*See Acknowledgments for participating organizations

CS278322-A
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Operational Protocol for U.S.-Mexico Binational Communication and Coordination on Disease Notifications and Outbreaks

Operational Protocol for U.S.-Mexico Binational Communication 

and Coordination on Disease Notifications and Outbreaks

Table of Contents

1. Introduction .

2. Purpose  

3. Events Leading to a Binational Communication .

4. Communication between Counterparts .

5. Information Included in Binational Communications .

6. Conducting Binational Communications .

7. Conducting Binational Outbreak Investigations .

Acknowledgments .

Appendix 1: IHR (2005) .

Appendix 2: U.S. and Mexico Case Definitions of Binationally Notifiable Conditions .

Appendix 3: Binational Contact Numbers .

Appendix 4: Template Terms of Reference for a Binational Outbreak Investigation  

Appendix 5: Procedures for Sharing Laboratory Resources and Specimens during 

Public Health Events of Mutual Interest and Binational Outbreaks . 

Appendix 6: List of Agencies and Organizations .

Appendix 7: Text Descriptions of Figures  

Tables and Figures

Figure 1: Map of States Along the United States-Mexico Border. .

Table 1: List of Binationally Notifiable Conditions .

Figure 2: U.S.–Mexico Communications Pathway for Routine or Emergency Events  

Table 2: Major U.S.–Mexico Sister City Pairs .

Table 3: Variables for Binational Case Notification .

Figure 3: Decision Tool For Confirming a Binational Outbreak and Initiating an Investigation .
Operational Protocol for U.S.-Mexico Binational Communication and Coordination on Disease Notifications and Outbreaks

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1. Introduction 

This document intends to serve as an operational protocol (i.e., the “Protocol”) for U.S. and Mexico public health 

officials. It is meant to provide guidance for implementing communication and follow up of binational cases and for 

identifying and collaborating on binational outbreaks when mutually deemed appropriate. 

The stimulus for the Protocol is a joint declaration by the U.S. and Mexico Secretaries of Health, signed in 2012 to 

implement the principles set forth in the “Technical Guidelines for United States—Mexico Coordination on Public Health 

Events of Mutual Interest,” also known as the “Guidelines.” The Guidelines call for the development of clearly defined 

pathways between public health agencies of both countries for communication of relevant epidemiologic information 

and to maximize the potential for coordinated public health action based on such information. This document fulfills 

these recommendations.

The U.S.-Mexico Binational Technical Work Group (BTWG) is a binational cross-cutting steering group that 

meets monthly and consists of border health partners from state and federal agencies in both countries. The BTWG 

developed communications pathway in collaboration with the United States Council of State and Territorial 

Epidemiologists (CSTE) after conducting a pilot primarily in the U.S. states of Arizona, New Mexico, and Texas, 

and the Mexican state of Sonora. In July 2015, this same group worked on a binational outbreak protocol during a 

binational tabletop outbreak exercise in Mexico City. BTWG members decided during the exercise that integrating 

the communication pathway and outbreak protocols into one document would be useful and fulfill the intent of the 

Secretaries of Health.

Figure 1: Map of states along the United States-Mexico Border. 

Source: CDC.
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2. Purpose

It is understood that communication and outbreak procedures already exist in local and state jurisdictions on both 

sides of the U.S-Mexico border, which harmonize with the recommendations of this Protocol. The operational 

guidelines in this Protocol are not intended to replace, duplicate, or change, in any way, either country’s state and 

national policies, regulations, or standard operating procedures; rather, they reflect the consensus recommendations of 

the BTWG for binational collaboration. 

The purpose of this protocol is to:

w Facilitate and systematize communications about disease events between all public health entities in the 

United States and Mexico that need awareness.

w Promote effective collaboration of public health systems of the United States and Mexico on outbreaks or 

binational cases affecting both countries.

w Provide a recommended list of binationally notifiable conditions 

w Provide clear and practical steps for preventing miscommunication and maximizing productive binational 

collaboration.

w Work within and complement existing communications mechanisms within each state and country to 

report events.

This is a living document and is intended to encourage ongoing discussion with health authorities in Mexico and the 

United States about future updates, including to the binationally notifiable list.
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3. Events Leading to a Binational Communication

Public Health Emergency of International Concern (potential or actual)

In the case of either a potential or actual (WHO-declared) public health emergency of international concern (PHEIC), 

priority will be given to reporting using the IHR protocol. Appendix 1 provides the decision instrument for assessing 

whether an event is to be considered a domestic potential PHEIC that should be notified to the Pan American Health 

Organization (PAHO)/World Health Organization (WHO), and examples for the application of the instrument. 

w PAHO is notified in the event of a suspected PHEIC through countries’ respective IHR National Focal 

Points (NFP).

w PAHO may be notified by member countries of any disease circumstance for which PAHO assistance is 

being considered. 

The IHR NFP of Mexico (maintained in DGE) may communicate directly with the IHR NFP of the United States 

(maintained in the Office of the Assistant Secretary for Preparedness and Response [ASPR])—and vice versa—on any 

international public health matter, including those that affect the border states. Respective federal procedures to assess 

and report potential PHEIC are slightly different, but will occur effectively outside of the scope of this Protocol with 

information provided back to the state levels through established communication pathways in CDC and DGE.

Binational Cases and Outbreaks 

This protocol calls for reporting of all instances of conditions included in the binationally notifiable list and which 

meet the binational case definition, as outlined in the Guidelines.

Definition of Binational Cases1

The term “binational case” refers to a confirmed or probable case of disease or other health event in an individual:

w Who has recently traveled or lived in a neighboring country, or had recent contact with persons who lived or 

traveled in a neighboring country; 

w Who is thought to have acquired the disease in a neighboring country or have been in the neighboring country 

during the incubation period of an infection and was possibly contagious during this period; 

w Who is thought to have acquired the disease from a product or other exposure in the other country; or 

w Whose case requires the collaboration of both countries for the purposes of disease investigation and control, 

regardless of the presumed site of infection or exposure

1 Taken from Guidelines for US-Mexico Coordination on Public Health Events of Mutual Interest

http://www.cdc.gov/USMexicoHealth/pdf/us-mexico-guidelines.pdf
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The Council of State and Territorial Epidemiologists (CSTE) considers a notifiable case to be binational when it meets 

one or more of the following criteria:2

w Potentially exposed while in Mexico (or Canada)

w Potentially exposed by a resident of Mexico (or Canada)

w Resident of (Canada or) Mexico

w Has case contacts in or from Mexico (or Canada)

w Exposure to suspected product from (Canada or) Mexico

w Other situations that may require binational notification or coordination of response (e.g., a measles outbreak 

without known cross border contacts in a border community or state; exposure to an exported product from the 

United States to Canada [or Mexico])

(Note—This binational protocol applies only to binational cases with Mexico, whereas the CSTE position statement 

also applies to binational cases with Canada.)

Binationally Notifiable Conditions

Table 1 specifies a list of notifiable conditions that should be reported binationally if they meet the definition of a 

binational case. This list was developed based on a subset of each country’s notifiable diseases with priority on high 

consequence, high virulence, highly transmissible conditions of mutual public health importance, including suspected 

bioterrorism and those conditions which will lead to public health action following a binational report. 

Both countries must realize that their respective surveillance case definitions may not be identical. Appendix 2 provides 

URLs to the respective case definitions of binationally notifiable conditions.

Certain notifiable diseases of international public health importance, such as measles and unusual outbreaks of 

interest are to be reported regardless of whether specific binational cases (e.g., with travel history) are identified. This 

information will be shared in as timely a fashion as possible to enhance binational situational awareness.

The conditions included in this list may be altered in the future, based on future discussions between health authorities 

of Mexico and the United States, as part of periodic reviews of this Protocol.

2 Council of State and Territorial Epidemiologists (CSTE) Position Statement 13-SI-02: Binational Case Variable Definition 

http://c.ymcdn.com/sites/www.cste.org/resource/resmgr/PS/13-SI-02.pdf
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Table 1: List of Binationally Notifiable Conditions3

All binational outbreaks

Unusual conditions of special public health concern

IHR reportable (within 24 hours):

Always:

w Smallpox

w Polio

w Human influenza, new subtype

w SARS

w Ebola

Potentially:

w Cholera

w Plague

w Yellow Fever

w Biological, radiological, or 

chemical events

w Any other event being considered for notification 

to WHO under the IHR

Others:

w Brucellosis

w Campylobacteriosis

w Legionellosis

w Listeriosis

w Meningococcal Disease

w Rabies, human

w Salmonellosis

w Shigellosis

w Syphilis

w Tuberculosis4

w Vaccine preventable diseases

§ viral hepatitis

§ measles

§ pertussis

§ rubella

§ tetanus 

§ varicella

w Vectorborne Diseases 

§ Chikungunya

§ Rickettsial diseases

§ Severe dengue

§ West Nile Virus

§ Zika

3 Confirmed and probable cases meeting binational case definition. Suspect cases also reported if situational awareness warrants such a report 

(e.g., high probability suspect measles). This list includes consensus conditions for which binational notification is strongly suggested; however, 

other conditions may be reported as necessary.

4 Note: Tuberculosis notification between the United States and Mexico is frequently managed by binational referral programs, such as CureTB, 

in coordination with local, state, and federal authorities.
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4. Communication between Counterparts

Figure 2: U.S.–Mexico Communications Pathway for Routine or Emergency Events

Solid arrows refer to communications within each country simultaneously inform all other levels of government

Dotted arrows refer to communication pathways contingent on events occurring in border settings or public health 

emergencies of international concern (PHEIC), as defined by the International Health Regulations 

ASPR = Assistant Secretary for Preparedness and Response

DGE = Mexican Directorate General of Epidemiology

HD = Health Department

PAHO = Pan American Health Organization

PHEIC = Public Health Event of International Concern

MX = Mexico

It is recommended that information be shared as soon as possible after the time of the event being reported. Initial 

reports of binational cases or events are most likely to originate from local or state jurisdictions in states along the 

U.S. and Mexico border. First communications of binational cases and outbreaks originating from local or state 

jurisdictions (both in border and non-border states) will be made with federal health authorities in the country where 

identified, as described below. 
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Table 2: Major U.S.–Mexico Sister City Pairs

San Diego, California—Tijuana, Baja California

Calexico, California—Mexicali, Baja California

Yuma, Arizona—San Luis Río Colorado, Sonora

Nogales, Arizona—Nogales, Sonora

Douglas, Arizona—Agua Prieta, Sonora

El Paso, Texas—Ciudad Juárez, Chihuahua

Presidio, Texas—Ojinaga, Chihuahua

Del Rio, Texas—Ciudad Acuña, Coahuila

Eagle Pass, Texas—Piedras Negras, Coahuila

Laredo, Texas—Nuevo Laredo, Tamaulipas

McAllen, Texas—Reynosa, Tamaulipas

Brownsville, Texas—Matamoros, Tamaulipas

United States

A. For urgent notifications, the CDC Emergency Operations Center (EOC) should 

be called at 770-488-7100 or 1-866-638-9753.

w The EOC can connect callers directly with CDC Division of Global Migration and Quarantine (DGMQ) U.S.-

Mexico Unit on-call duty officer and any additional CDC program that may need to be informed.

w If working with a CDC Division other than CDC/DGMQ, arrangements 

may be made with that CDC Division for notification of CDC/DGMQ 

U.S.-Mexico Unit 

w For all cases, an email should also be sent to CDC DGMQ U.S.-Mexico Unit, usmunotify@cdc.gov

B. For binational communications, for each level of government (local, state, and federal), this protocol identifies 

focal points of contact. For the federal level, and counterpart to the Mexican DGE, the focal point is the CDC.

C. Immediate communication should take place between border sister cities and border states, when the 

epidemiologic situation requires it. This should always include an immediate notification to the next jurisdictional 

level (state) about the situation in its respective area and information on the actions that are being taken between 

the sister cities or border states of both countries. 

D. For routine notifications, an email is to be sent to the CDC DGMQ U.S.-Mexico Unit, usmunotify@cdc.gov. 

Immediate notification to the federal level regarding communications between neighboring states, as well as 

communications between sister cities, should also occur.

E. For all notifications, confidential information:

w May be shared by telephone;

w May be sent via Epi-X Notification Forum; or 

w May be sent via email attachment using a password-protected PDF, with password included in a separate email.
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When appropriate, CDC DGMQ U.S.-Mexico Unit will notify the DGE using established channels of 

communication and copy the respective CDC program(s) involved, the United States IHR NFP, and PAHO.

Mexico

A. For urgent notifications, the Unidad de Inteligencia Epidemiologica y Sanitaria (UIES) of the DGE should be 

called at 01-800-0044800. 

w The UIES can connect callers directly with DGE, Dirección General Adjunta de Epidemiología (DGAE), 

Instituto de Diagnóstico y Referencia Epidemiológicos (DGA-InDRE), Centro Nacional de Programas 

Preventivos y Control de Enfermedades (CENAPRECE), and any additional Mexican Secretaria de Salud 

program that may need to be informed. 

w For all cases, an email should also be sent to DGE-UIES, uies@salud.gob.mx.

B. For binational communications, for each level of government (local, state, and federal), this protocol identifies 

focal points of contact. For the federal level, and counterpart to CDC, the focal point is DGE.

C. Immediate communication should take place between border sister cities and border states, when the 

epidemiologic situation requires it. This should always include an immediate notification to the next jurisdictional 

level (state) about the situation in its respective area and information on the actions that are being taken between 

the sister cities or border states of both countries.

D. For routine notifications, an email is to be sent to the uies@salud.gob.mx. Immediate notification to the federal 

level regarding communications between neighboring states, as well as communications between sister cities, 

should also occur.

E. For all notifications, confidential information:

w May be shared by telephone;

w May be sent via Epi-X Notification Forum; or 

w May be sent via email attachment using a password-protected PDF, with password included in a separate email.
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5. Information Included in Binational Communications

A recommended variable list specifying key epidemiologic information to be used for reporting binational outbreaks 

is provided in Table 3. Information may be provided for confirmed and probable cases meeting binational case 

definition. Suspect cases could be reported if situational awareness warrants such a report (e.g., high probability 

suspect measles). Additional variables can be added by states to their respective binational case report/outbreak 

report forms as needed. Information to be provided is subject to availability; if additional information is critical to an 

investigation, specific requests can be made to the respective agencies (local and state governments). 

It is best if personal identifiers are removed for these health communications, unless agencies from either country 

receiving the communications are already directly involved in public health actions with an individual.

The amount of detail included in the reports will be determined by the local agency, varying in scope from a “for your 

information (FYI)” notice to a full case report with identifying information for cases requiring public health action. 

Providing binational reports in both English and Spanish are recommended wherever possible.

Feedback on follow-up activities and actions taken after the initial communication is made (e.g., contact 

investigations) is to be shared between countries within the time period requested, ideally no longer than 2 weeks. It is 

understood that local health departments may have delays in completing epidemiologic investigations and obtaining 

laboratory confirmation to report to state health authorities. For suspect cases, laboratory information would be shared 

once available.
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Table 3: Variables for Binational Case Notification

Disease ❏ Disease/illness

❏ Subcategory as applicable (e.g., serovariant)

Patient Demographics ❏ Age

❏ Sex

❏ Country of Residence

Travel History ❏ Date(s) of Departure

❏ Date(s) of Return

❏ Location(s) of Travel—as specific as possible

❏ Exposure information—as specific as possible

Laboratory5 ❏ Date of onset of symptoms

❏ Symptom list

❏ Date of vaccination (if applicable)

❏ Date of specimen(s) collected

❏ Type of specimen(s)

❏ Laboratory test(s) performed

❏ Result(s)

Case Definition Criteria ❏ How the illness meets the CSTE/CDC or Mexico case definition (epidemiologic, clinical 

and laboratory criteria)

Nature of Binational Designation 

(select all that apply)

❏ Traveled to or lived in another country during the incubation period for the disease

❏ Had contact with an infected person from another country during the incubation 

period for the disease

❏ Had exposure to a suspected product (such as food, herb, or cosmetic) from another 

country (include product information)

❏ Is a resident of Mexico

❏ Is a resident of the United States

Missing Data ❏ Patient was unable or unwilling to provide relevant demographic, clinical and 

epidemiologic information (please select if applicable, rather than leaving 

fields blank)

POC Information [name/contact information of local/state/federal official notifying case]

Date of notification [DD/MM/YYYY]

Date by when follow-up on 

public health actions taken will 

be shared (no more than two 

weeks) 

[DD/MM/YYYY]

5 Procedures for sharing laboratory resources and specimens at the federal level during public health events of mutual interest are outlined in 

Appendix 5.
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6. Conducting Binational Communications

The BTWG recommends that information be shared as close to simultaneous as possible. It is understood that 

different state, local, and national health authorities may use different software to record, store, and share case 

information and also have differing information security requirements. It might, therefore, be necessary to adapt 

communication mechanisms so partner agencies can access the information

In general, preliminary communications should be made through secure communication channels. 

w Communications involving necessary identifying information are to use a secure mechanism, such as telephone, 

Epi-X Binational Notification Forum (which automatically makes simultaneous notifications) or email with 

password-protected PDF files. Other mechanisms for sharing confidential information may be identified in 

consultation with agencies involved, taking into account the most feasible means for a given partner.

Routine informational notifications without identifying or sensitive information may be sent via email or fax.

Urgent binational communications

w Urgent notifications for which rapid public health action is recommended should be timely and contain detailed 

case and exposure information to facilitate an effective follow-up response.

w Telephone notification is strongly recommended through the respective 24-hour binational contact numbers 

(Appendix 3). Each level of government identifies their preferred primary and secondary points of contact (e.g., 

emergency phone numbers and organizational entities within the agency), who should receive binational reports.

w Follow-up informational notifications for situational awareness are beneficial and should be used together with 

official reporting. See IHR Annex 2 (Appendix 1) for more information on reporting
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7. Conducting Binational Outbreak Investigations

This section provides guidance for mutual determination of a binational outbreak and operational suggestions for 

conducting a binational outbreak investigation based on epidemiologic and laboratory best practices, as well as 

experiences from binational outbreak investigations based on input from key participants. Coordination for binational 

outbreak investigations and responses benefits from ongoing, transparent, and clear communication following the 

above recommendations.

This guide recognizes that each outbreak situation is unique and that the approach to the investigation will vary 

by situation. The steps outlined here clarify best practices and recommendations for initiating and conducting a 

binational investigation that addresses the general epidemiologic situation of an outbreak and meets the needs of both 

countries.

This implementation guide does not replace local, state, or national public health agency standard operating 

procedures. If outbreak investigation guidelines and instruments exist at the local level, those take precedence, and will 

be consulted first and adapted to the binational needs as appropriate.

A. Recommended process for determining a binational outbreak

Trigger: A local, state, or federal entity in either country detects a greater-than-expected occurrence of a condition 

in their jurisdiction.

i. Local and state outbreak investigation/outbreak protocols are activated. 

ii. Health officials at the local level evaluate cases to see if any cases associated with the outbreak meet the 

binational case definition (Appendix 2).

iii. If cases are binational, they will be reported to the corresponding authorities in both countries, in 

accordance with the U.S.-Mexico Binational Communication Pathways Protocol.

iv. Updated case and/or outbreak information should be promptly shared by the respective jurisdictions, 

with corresponding authorities based on the ongoing investigation for the duration of the outbreak. 

v. Depending on the level of priority, a decision may be made to request a binational call to discuss 

current epidemiologic and laboratory data with counterparts from the other country. 

vi. The binational authorities may evaluate and discuss the data and decide whether a binational outbreak 

investigation will be initiated. 
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Figure 3: Decision Tool For Confirming A Binational Outbreak And Initiating An Investigation*

* Following IHR Annex 2, see Appendix 1

** See Table 1

† See Appendix 2

‡ See Appendix 1 for a definition of a “serious case”
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Once it is decided to conduct a binational outbreak investigation, the following steps are recommended:

B. Establishing a Terms of Reference (TOR) for a Binational Outbreak Investigation

When deemed appropriate by binational authorities, establishing TORs at the beginning of a binational outbreak 

investigation will help ensure the scope and aspects of the investigation are similarly understood and agreed upon 

at all government levels in both countries. 

Typical components of a TOR document include:

I. Background

i. Epidemiologic case definition

ii. Epidemiologic information: case counts, suspected diagnoses, location, time period, lab confirmation, 

background epidemiologic information

iii. Collaborating institutions

II. Collaborative investigation steps

i. Forming a binational investigation team (see below)

ii. Drafting an investigation protocol (see below)

iii. Identification of necessary resources and supplies, including laboratory testing. Explicitly indicate who 

will provide what resources, and how they will be shared

III. Signatures of representative health officials

i. Inclusion of space for the signatures of representatives of the collaborating agencies at the end of the 

document.

ii. Signatures ratify the TOR and signal the initiation of the binational investigation.

Appendix 4 provides an example TOR document

C. Determining Binational Investigation Team Roles and Responsibilities 

During a binational outbreak investigation, the local/state public health authorities in whose jurisdiction the 

outbreak is occurring will lead outbreak investigation activities. Depending on their local capacity, they can 

request assistance from partners (federal, binational) to meet resource needs, including subject matter expertise.

Formation of Binational Investigation Team—Both countries can work together to form a binational team with 

members from both countries, ideally including local, state, and federal counterparts. Formation of a binational 

investigation team to confirm the diagnosis, determine the scale of the outbreak, identify significant risk factors, 

and implement appropriate control measures may greatly facilitate the investigation and inform public health 

control measures. 

Once assembled, it is important for team members to meet and establish an 

onsite lead.

Clear delineation of roles, responsibilities, and expectations of team members will be beneficial, including 

establishment of an organizational chart, which could be posted in a visible location for the outbreak team. The 

team can schedule regular meetings with binational investigation team for planning investigation, either by phone 

or in person. 

Data Sharing—When deemed appropriate and proper approvals are obtained by both countries, case information 

with non-identifiable data may be shared by appropriate measures on a pre-determined and mutually agreeable 

frequency. In some cases, creation of a binational database may be warranted, the creation of which must be 

approved by appropriate authorities in both countries.
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D. Binational Investigation Protocol 

When deemed appropriate, the binational investigation team might draft a supplemental investigation protocol 

based on these guidelines, including the aims of the investigation that are unique to epidemiologic situation, 

case definitions, survey instruments with supplemental investigation questions, and data-sharing procedures. 

Depending on the circumstances, Institutional Review Board (IRB) consideration might be necessary. Check with 

federal, state, and local agencies to determine the appropriate approval process(es) early on and plan for potential 

delays that need to be worked into the investigation timeline. 

I. Aims

To determine the aims of the investigation, it is recommended that the binational investigation team:

1) Use data from both countries to characterize the outbreak of the apparent syndrome and possible risk 

factors. 

2) Identify the possible source of the outbreak and implement control measures. 

3) Confirm the diagnosis (see Appendix 2 for U.S. and Mexico case definitions).

4) Determine the scale of the outbreak by reviewing the region’s past epidemiological data and compare 

current rates to those expected.

5) Identify significant risk factors. During the investigation, it will be important to review existing 

literature and talk with local health authorities to compile a picture of possible risk factors as more 

information is obtained from hypothesis generating and other interviews or data sources.

6) Serve as support mechanism for local, state, and federal authorities to assist in establishing or improving 

control measures as identified.

II. Case definitions

The various institutions participating in a binational investigation might use differing case definitions 

— both within each country and across countries. The BTWG suggests that the binational investigation 

team review each country’s existing definitions and determine if they are appropriate for the outbreak at 

hand or if they need to be revised. 

III. Supplemental Binational Outbreak Survey Questions and Instruments

During an outbreak, the binational team will use the existing survey instruments from the respective local 

jurisdiction(s), as appropriate. However, given the unique conditions of a binational outbreak, it may 

be necessary for the team to develop additional questions to address the binational component of the 

outbreak—possibly to create a new instrument, a supplemental outbreak survey instrument, or a revised 

instrument. 

A discussion of the basis for inclusion of questions each institution considers important allows the team 

to learn from each other. During the evaluation of what questions to include in the instrument, the 

team might consider the evidence to-date and the angle the investigation might take; this helps shorten 

the instrument and make it specific to the outbreak. Consensus may be difficult, and some additional 

questions may be needed to proceed with binational agreement on the instrument.

Once the supplemental survey questions or instrument are drafted, the BTWG recommends piloting the 

document and updating the content based on feedback with a focus on readability, clarity, and the time it 

takes to administer. All survey instruments and aides that will be shown to participants can be included as 

appendices to the protocol.

IV. Hypothesis Generation

The binational investigation team may conduct hypothesis-generating interviews with cases using a survey 
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that explores various hypotheses to learn more about the cases, their illness, and potential exposures, for 

subsequent formulation of the investigation hypotheses. A sample of the cases may be interviewed with a 

longer survey for further analysis.

V. Database

The binational field team may agree on a method for sharing a pre-existing database or creating a new 

binational outbreak investigation database accessible by all collaborating agencies’ participating field team 

members. This can be challenging, as each institution may have firewalls and limit access to pre-identified 

users. Another option is to consider using Epi-Info to create the database and use for data entry, if both 

countries have access to the same version.

Epi-X can be used as a forum to securely store surveys and database files. CDC Epi-X helpdesk 

(epixhelp@cdc.gov) can provide support.

Establishment of a database management team within the binational field team, that has experience 

creating, saving, and backing up databases is instrumental. The database usually needs to be translated, 

but other options include:

w Use both the Spanish and English names for each variable in the database.

w Use only one language and then translate the report.

w Use bilingual data entry staff so the data are entered in one language regardless of the language of the 

survey instrument.

For ease of use and clarity, it is recommended that the database is up-to-date and has a data dictionary. It 

is also helpful if information is captured in a complete and standardized manner.

If there are distinct facets of the investigation, distinct databases (i.e., a database for a case-control study, 

another for hypothesis-generating interviews, and one for environmental sampling) may be useful.

VI. Logistics

1) Binational travel

Consider modes of transportation and documents needed (i.e., passport). In the event of an emergency, 

it may be possible to request assistance from the State Department (for entry into the United States). 

However, it is preferable to select team members with required documentation.

2) Hotel accommodations

In selecting a hotel, the team might consider proximity to daily activities, as well as restaurants open 

early in the morning and late at night. An available private meeting room is beneficial for team 

meetings. A buddy system will allow team members to fill in for each other in the event that someone 

is unwell or rotates back to their normal duties. 

3) Daily travel

Rental car or official agency vehicles can be used for transportation. Certain agencies prohibit travel to 

Mexico, and it is recommended to seek appropriate approvals. Due to border wait times and customs 

procedures, it is typically easiest to leave a vehicle at the border and cross by foot, then contract an 

official taxi or organize a ride with local field team members. 

4) Resources and supplies

It is recommended that the field team identifies the resources needed to carry out the binational 

outbreak investigation early on, takes stock of available resources, and discusses how they will be 

shared, along with the process for requesting and procuring additional items. Resource-sharing among 

participating agencies is encouraged, along with an effort to place minimal burden on the local 
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institution to avoid depleting their resources. Appendix 5 provides guidance for sharing of laboratory 

resources and specimens.

Common needs might include:

w Office supplies: paper, pens, clipboards, maps.

w Equipment: computer, internet access, photocopier.

w Laboratory supplies: testing supplies to confirm cases, as well as items needed to prepare, preserve, 

and ship samples, including centrifuges and refrigeration equipment.

w Approvals: security clearance and immigration requirements. 

E. Reporting

The BTWG recommends that the outbreak team agree on a shared plan for reporting results of the 

investigation that is mutually acceptable to both countries. 

I. Press releases

During an outbreak, each jurisdiction follows its existing protocols for press releases and information 

disseminated to the public. The binational investigation team can serve as a support mechanism if a joint 

binational press release is warranted. International entities, such as PAHO, have been instrumental in past 

outbreaks by issuing a binational IHR alert, developed jointly on behalf of both countries. 

It is recommended that information, case counts, data summaries, key talking points, and other 

information are consistent in press releases issued by different agencies to reduce confusion. It can be 

beneficial for authorities to let their binational counterparts know when planning a press release for 

situational awareness. This is particularly important in a binational region where residents of both 

countries obtain information from media sources on both sides of the border. 

II. Travel health alerts

As with press releases, the binational team can provide input to federal agencies regarding the decision to 

issue a travel health alert; however, the ultimate prerogative lies with each government. It is recommended 

to consider all options for accomplishing the goal of protecting the health of travelers, given the potential 

economic impact associated with a health alert.

III. Progress reports to binational field team

Binational field team leads will organize regular progress reports for field team members during the 

course of the investigation. While the field team decides the frequency of the updates, daily updates are 

recommended in the early stages of investigation. The binational field team might consider agreeing 

upon a standard time and reliable mode for communication to ensure all team members can participate. 

Updates might include case counts, changes in definitions, information on the environmental, 

epidemiologic, or laboratory aspects of the investigation, problems, successes, and needs.

IV. Final report

Once the investigation has been completed, it is recommended that the binational investigation 

team takes the lead in writing a final report summarizing all investigation activities, main findings, 

and recommendations. The report might need to be translated, cleared by both countries’ clearance 

mechanisms, and completed within 3 months of the conclusion of the investigation. The binational 

investigation team might discuss the possibility of writing a manuscript and publishing the findings.
Operational Protocol for U.S.-Mexico Binational Communication and Coordination on Disease Notifications and Outbreaks

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F. Wrap-up and follow-up

After completing the final report and circulating to relevant partner agencies, the BTWG recommends that the 

binational field team continue sharing information about any follow-up activities and monitor case counts. 

Follow-up studies may be helpful in further describing the development and resolution of the cases. These 

might warrant a second binational investigation at a later date, and members of the binational field team can be 

consulted or included to ensure continuity of data collection and transfer of knowledge. 

The outbreak team can also conduct an after-action debrief of the investigation to discuss and document what 

went well and items for improvement in future binational investigations.
Operational Protocol for U.S.-Mexico Binational Communication and Coordination on Disease Notifications and Outbreaks

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Acknowledgements

The development of this protocol was a collaboration of the U.S.-Mexico Binational Technical Work Group and 

additional partners, including:

United States:

California Department of Public Health

California Office of Binational Border Health

Arizona Department of Health Services

Arizona Office of Border Health

New Mexico Department of Health

New Mexico Office of Border Health

Texas Department of State Health Services

Texas Office of Border Health

Centers for Disease Control and Prevention

U.S.-Mexico Unit, Division of Global Migration and Quarantine

Centers for Global Health

Office of the Associate Secretary for Preparedness and Response

Office of Policy and Planning, Division of International Health Security, 

IHR Branch

Mexico:

Secretaria de Salud del Estado de Baja California

Secretaria de Salud de Sonora

Secretaria de Salud de Chihuahua

Secretaria de Salud Coahuila

Secretaria de Salud de Nuevo León

Secretaria de Salud de Tamaulipas

Dirección General de Epidemiología
Operational Protocol for U.S.-Mexico Binational Communication and Coordination on Disease Notifications and Outbreaks

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Appendix 1: IHR (2005)

Annex 2

Decision Instrument for the Assessment and Notification of Events 

That May Constitute a Public Health Emergency of International Concern

1

 As per WHO case definitions.

2

 The disease list shall be used only for the purposes of these Regulations.
Operational Protocol for U.S.-Mexico Binational Communication and Coordination on Disease Notifications and Outbreaks

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Examples for the Application of the Decision Instrument for the Assessment and 

Notification of Events That May Constitute a Public Health Emergency of International Concern

The examples appearing in this Annex are not binding and are for inicicative guidance purposes to assist in the 

interpretation of the decision instrument criteria. 

DOES THE EVENT MEET AT LEAST TWO OF THE FOLLOWING CRITERIA?

I. Is the public health impact of the event serious?

1. Is the number of cases and/or number of deaths for this type of even large for the given place, time, or population?

2. Has the even the potential to have a high public health impact?

The following are examples of circumstances that contribute to high public health impact:

9 Event caused by a pathogen with high potential to cause epidemic (infectiousness of the agent, high case fatality, 

multiple transmission routes or healthy carrier).

9 Indication of treatment failure (new or emerging antibiotic resistance, vaccine failure, antidote resistance or failure).

9 Event represents a significant public health risk even if no or very few human cases have yet been identified.

9 Cases reported among health staff.

9 The population at risk is especially vulnerable (refugees, low level of immunization, children, elderly, low immunity, 

undernourished, etc.). 

9 Concomitant factors that may hinder or delay the public health response (natural catastrophes, armed conflicts, 

unfavorable weather conditions, multiple foci in the State Party).

9 Event in an area with high population density.

9 Spread of toxic, infectious or otherwise hazardous materials that may be occurring naturally or otherwise that has 

contaminated or has the potential to contaminate a population and/or a large geographical area.

3. Is external assistance needed to detect, investigate, respond and control the current event, or prevent new cases?

The following are examples of when assistance may be required:

9 Inadequate human, financial, material or technical resources—in particular:

§ insufficient laboratory or epidemiological capacity to investigate the event (equipment, personnel, financial resources);

§ insufficient antidotes, drugs, and/or vaccine and/or protective equipment, decontamination equipment, or supportive 

equipment to cover estimated needs;

§ existing surveillance system is inadequate to detect new cases in a timely manner.

IS THE PUBLIC HEALTH IMPACT OF THE EVENT SERIOUS?

Answer “yes” if you have answered “yes” to questions 1, 2, or 3 above.
Operational Protocol for U.S.-Mexico Binational Communication and Coordination on Disease Notifications and Outbreaks

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II. Is the event unusual or unexpected?

4. Is the event unusual?

The following are examples of unusual events:

9 The event is caused by an unknown agent or the source, vehicle, route of transmission is unusual or unknown. 

9 Evolution of cases more severe than expected (including morbidity or case-fatality) or unusual symptoms. 

9 Occurrence of the event itself is unusual for the area, season, or population.

5. Is the event unexpected from a public health perspective?

The following are examples of unexpected events:

9 Event caused by a disease/agent that had already been eliminated or eradicated from the State Party or not previously 

reported.

IS THE EVENT UNUSUAL OR UNEXPECTED?

Answer “yes” if you have answered “yes” to questions 4 or 5 above.

III. Is there a significant risk of international spread?

6. Is there evidence of an epidemiological link to similar events in other States?

7. Is there any factor that should alert us to the potential for cross border movement of the agent, vehicle, or host?

The following are examples of circumstances that may predispose to international spread:

9 Where there is evidence of local spread, an index case (or other linked cases) with a history within the previous month of:

§ international travel (or time equivalent to the incubation period if the pathogen is known);

§ participation in an international gathering (pilgrimage, sports event, conference, etc.);

§ close contact with an international traveler or highly mobile population.

9 Event caused by an environmental contamination that has the potential to spread across international borders.

9 Even in an area of intense international traffic with limited capacity for sanitary control or environmental detection or 

decontamination.

IS THERE A SIGNIFICANT RISK OF INTERNATIONAL SPREAD?

Answer “yes” if you have answered “yes” to questions 6 or 7 above.

IV. Is there a significant risk of international travel or trade restrictions?

8. Have similar events in the past resulted in international restriction on trade and/or travel?

9. Is the source suspected or known to be a food product, water, or any other goods that might be contaminated that has been 

exported/imported to/from other States?

10. Has the event occurred in association with an international gathering or in an area of intense international tourism?

11. Has the event caused requests for more information by foreign officials or international media?

IS THERE A SIGNIFICANT RISK OF INTERNATIONAL TRADE OR TRAVEL RESTRICTIONS?

Answer “yes” if you have answered “yes” to questions 8, 9, 10, or 11 above.

States Parties that answer “yes” to the question whether the event meets any two of the 

four criteria (I-IV) above, shall notify WHO under Article 6 of the International Health Regulations.
Operational Protocol for U.S.-Mexico Binational Communication and Coordination on Disease Notifications and Outbreaks

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Appendix 2: U.S. and Mexico Case Definitions of Binationally 

Notifiable Conditions

NOTIFIABLE 

CONDITION

DEFINITIONS

UNITED STATES MEXICO

IHR REPORTABLE CONDITIONS

ALWAYS

Smallpox http://wwwn.cdc.gov/nndss/conditions/

smallpox/case-definition/2004/

Page 23–24 

http://187.191.75.115/gobmx/salud/documentos/

manuales/13_Manual_Vig_Epid_Internacional.pdf

Page 20 

http://www.salud.gob.mx/unidades/cdi/documentos/

ManualAntrax.pdf

Poliomyelitis http://wwwn.cdc.gov/nndss/conditions/

poliomyelitis-paralytic/case-definition/2010/

Page 22

http://187.191.75.115/gobmx/salud/documentos/

manuales/13_Manual_Vig_Epid_Internacional.pdf

Page 78

http://187.191.75.115/gobmx/salud/documentos/

manuales/35_Manual_EPV.pdf

Influenza, new 

subtype

http://wwwn.cdc.gov/nndss/conditions/

novel-influenza-a-virus-infections/casedefinition/2014/

Page 21

http://187.191.75.115/gobmx/salud/documentos/

manuales/12_Manual_VE_Influenza.pdf

SARS http://wwwn.cdc.gov/nndss/conditions/

severe-acute-respiratory-syndromeassociated-coronavirus-disease/casedefinition/2003/07/

Page 22

http://187.191.75.115/gobmx/salud/documentos/

manuales/13_Manual_Vig_Epid_Internacional.pdf

Page 9 (2003)

http://www.salud.gob.mx/unidades/cdi/documentos/

manualSARS.pdf

Ebola http://wwwn.cdc.gov/nndss/conditions/

viral-hemorrhagic-fever/casedefinition/2011/

https://www.gob.mx/salud/acciones-y-programas/

normas-y-lineamientos-sobre-el-virus-del-ebola

Other Any disease/condition/event that meets at 

least 2 of the 4 criteria in the IHR Annex 2. 

Any disease/condition/event that meets at least 2 of 

the 4 criteria in the IHR Annex 2.

POTENTIALLY

Cholera http://wwwn.cdc.gov/nndss/conditions/

cholera/case-definition/1996/

Page 30

http://187.191.75.115/gobmx/salud/documentos/

manuales/06_Manual_Colera.pdf

Page 20 (Diarrheal diseases)

http://www.epidemiologia.salud.gob.mx/doctos/

infoepid/vig_epid_manuales/18_2012_Manual_

NuTraVe_vFinal_6nov12.pdf

Plague http://wwwn.cdc.gov/nndss/conditions/

plague/case-definition/1996/

Page 19 

http://www.salud.gob.mx/unidades/cdi/documentos/

ManualAntrax.pdf
Operational Protocol for U.S.-Mexico Binational Communication and Coordination on Disease Notifications and Outbreaks

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NOTIFIABLE 

CONDITION

DEFINITIONS

UNITED STATES MEXICO

Yellow Fever http://wwwn.cdc.gov/nndss/conditions/

yellow-fever/case-definition/1997/

Page 32

http://www.gob.mx/cms/uploads/attachment/

file/229912/Lineamientos_de_Vig_por_Lab_

Dengue_y_otros_Arb_V1_2017.pdf

Other Any disease/condition/event that is being 

considered for notification under the IHR 

Annex 2. 

Any disease/condition/event that is being considered 

for notification under the IHR

OTHER

Botulism http://wwwn.cdc.gov/nndss/conditions/

botulism/case-definition/2011/

Page 18 

http://www.salud.gob.mx/unidades/cdi/documentos/

ManualAntrax.pdf

Anthrax http://wwwn.cdc.gov/nndss/conditions/

anthrax/case-definition/2010/

Page 17–18 

http://www.salud.gob.mx/unidades/cdi/documentos/

ManualAntrax.pdf

Brucellosis http://wwwn.cdc.gov/nndss/conditions/

brucellosis/case-definition/2010/

Page 14

http://187.191.75.115/gobmx/salud/documentos/

manuales/03_Manual_Brucelosis.pdf

Page 16

https://www.gob.mx/cms/uploads/attachment/

file/159058/lineamientos_para_vigilancia_de_

brucelosis_2_.pdf

Campylobacteriosis http://wwwn.cdc.gov/nndss/conditions/

campylobacteriosis/case-definition/2015/

Legionellosis http://wwwn.cdc.gov/nndss/conditions/

legionellosis/case-definition/2005/

Listeriosis http://wwwn.cdc.gov/nndss/conditions/

listeriosis/case-definition/2000/

Meningococcal 

Disease

http://wwwn.cdc.gov/nndss/conditions/

meningococcal-disease/casedefinition/2015/

Page 21

https://www.gob.mx/cms/uploads/attachment/

file/201885/Lineamientos_IRAS_bac_170317.pdf

Rabies, Human http://wwwn.cdc.gov/nndss/conditions/

rabies-human/case-definition/2011/

Page 20 

https://www.gob.mx/cms/uploads/attachment/

file/209372/lineamientos_para_la_vigilancia_de_

rabia.pdf

Salmonellosis https://wwwn.cdc.gov/nndss/conditions/

salmonellosis/case-definition/2017/

Page 20 

http://187.191.75.115/gobmx/salud/documentos/

manuales/21_Manual_NuTraVe.pdf

Shigellosis https://wwwn.cdc.gov/nndss/conditions/

shigellosis/case-definition/2017/

Page 20 

http://187.191.75.115/gobmx/salud/documentos/

manuales/21_Manual_NuTraVe.pdf

Syphilis http://wwwn.cdc.gov/nndss/conditions/

syphilis/case-definition/2014/

http://187.191.75.115/gobmx/salud/documentos/

manuales/31_Manual_SIFILIS.pdf
Operational Protocol for U.S.-Mexico Binational Communication and Coordination on Disease Notifications and Outbreaks

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NOTIFIABLE 

CONDITION

DEFINITIONS

UNITED STATES MEXICO

Tuberculosis http://wwwn.cdc.gov/nndss/conditions/

tuberculosis/case-definition/2009/

Page 21

https://www.gob.mx/cms/uploads/attachment/

file/159059/Lineamientos_de_vigilancia_por_

laboratorio_de_tuberculosis.pdf

VACCINE PREVENTABLE DISEASES

Viral Hepatitis Page 20

http://187.191.75.115/gobmx/salud/documentos/

manuales/11_Manual_HepatitisVirales.pdf

Measles http://wwwn.cdc.gov/nndss/conditions/

measles/case-definition/2013/

Page 30 

http://187.191.75.115/gobmx/salud/documentos/

manuales/35_Manual_EPV.pdf

Pertussis http://wwwn.cdc.gov/nndss/conditions/

pertussis/case-definition/2014/

Page 104 

http://187.191.75.115/gobmx/salud/documentos/

manuales/35_Manual_EPV.pdf

Rubella http://wwwn.cdc.gov/nndss/conditions/

rubella/case-definition/2013/

Page 52 

http://187.191.75.115/gobmx/salud/documentos/

manuales/35_Manual_EPV.pdf

Tetanus http://wwwn.cdc.gov/nndss/conditions/

tetanus/case-definition/2010/

Page 169 

http://187.191.75.115/gobmx/salud/documentos/

manuales/35_Manual_EPV.pdf

Varicella http://wwwn.cdc.gov/nndss/conditions/

varicella/case-definition/2010/

http://187.191.75.115/gobmx/salud/documentos/

manuales/35_Manual_EPV.pdf

VECTORBORNE DISEASES

Chikungunya

Initial case each 

season in border 

state, binational, or 

otherwise

If exposure suspected 

in US and diagnosed in 

Mexico

http://wwwn.cdc.gov/nndss/conditions/

arboviral-diseases-neuroinvasive-and-nonneuroinvasive/case-definition/2015/

Page 29

http://www.gob.mx/cms/uploads/attachment/

file/229912/Lineamientos_de_Vig_por_Lab_

Dengue_y_otros_Arb_V1_2017.pdf

Severe dengue 

Initial case each 

season in border 

state, binational, or 

otherwise

If exposure suspected 

in US and diagnosed in 

Mexico

http://wwwn.cdc.gov/nndss/conditions/

dengue-virus-infections/casedefinition/2015/

Page 28

http://www.gob.mx/cms/uploads/attachment/

file/229912/Lineamientos_de_Vig_por_Lab_

Dengue_y_otros_Arb_V1_2017.pdf
Operational Protocol for U.S.-Mexico Binational Communication and Coordination on Disease Notifications and Outbreaks

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NOTIFIABLE 

CONDITION

DEFINITIONS

UNITED STATES MEXICO

Rickettsial Diseases 

(RMSF)

https://wwwn.cdc.gov/nndss/conditions/

rocky-mountain-spotted-fever/casedefinition/2008/

Page 18

https://www.gob.mx/cms/uploads/attachment/

file/201900/Lineamientos_Rick_130317.pdf

West Nile virus

Initial case each 

season in border 

state, binational, or 

otherwise

If exposure suspected in 

Mexico and diagnosed 

in US

http://wwwn.cdc.gov/nndss/conditions/

arboviral-diseases-neuroinvasive-and-nonneuroinvasive/case-definition/2015/

Page 31 

http://www.gob.mx/cms/uploads/attachment/

file/229912/Lineamientos_de_Vig_por_Lab_

Dengue_y_otros_Arb_V1_2017.pdf

Zika https://wwwn.cdc.gov/nndss/conditions/

zika-virus-disease-and-zika-viruscongenital-infection/case-definition/2016/

Page 29

http://www.gob.mx/cms/uploads/attachment/

file/229912/Lineamientos_de_Vig_por_Lab_

Dengue_y_otros_Arb_V1_2017.pdf
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Appendix 3: Binational Contact Numbers

UNITED STATES

U.S. Federal

Urgent Notification

1. Call CDC Emergency Operations Center: 770-488-7100 or 1-866-638-9753 (internal US only number)

2. Email: usmunotify@cdc.gov

Routine Notification

1. Email: usmunotify@cdc.gov

Arizona

Dr. Mariana G Casal, BIDS Surveillance Officer

Email: mariana.casal@azdhs.gov

Phone (24/7): 520-245-3233

Robert Guerrero, Chief Office of Border Health

Email: Robert.guerrero@azdhs.gov

Phone: 520-770-3113 (business hours); cell: 520-609-7344

24/7 phone: 602-839-5040

California

Dr. Esmeralda Iniguez-Stevens, BIDS Surveillance Officer

Email: einiguez@cdph.ca.gov

Phone: 619-688-0111 (business hours); cell: 619-672-5695

Dr. Margarita Santibanez

Email: margarita.santibanez@cdph.ca.gov

Phone: 619 571 3630

24/7 phone: 619-672-5695

New Mexico

Katharine Perez-Lockett, BIDS Surveillance Officer

Email: katharine.perez@state.nm.us

Phone: 575-528-5103

Sandra Melman

Email: Sandra.melman@state.NM.us

Phone: 505-827-0100

24/7 phone: 505-827-0006

Texas

Allison Banicki, Epidemiologist, Texas DSHS Office of Border Health

Email: Allison.banicki@dshs.state.tx.us

Phone: 512-776-7675 (Office of Border Health main number, business hours)

Cell: 512-284-3335

24/7 phone: 512-458-7111
Operational Protocol for U.S.-Mexico Binational Communication and Coordination on Disease Notifications and Outbreaks

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MÉXICO

México DGE

Dr. Javier Montiel Perdomo, Director of Operational Epidemiologic Investigations

Email: javier.montiel@salud.gob.mx

Phone (24/7): From Mexico: 01-800-00-44-800; From U.S: +52 55-53-37-18-44

Tamaulipas

Dr. Santos Daniel Carmona Aguirre, State Epidemiologist, Servicios de Salud del Estado de Tamaulipas

Email: drdaniel@hotmail.com; epidem.tamps@gmail.com; notifica.tamps@gmail.com; 

transmisibles.tamaulipas@gmail.com

Sonora

Dra. Imuvira Dénica Cruz Loustaunau: direccion.uiees.sonora@gmail.com

Dra. Tannia Lenina Fontes Martínez: fontestannia@hotmail.com

Chihuahua

Dr. Gumaro Barrios Gallegos, Epidemiólogo Estatal, Secretaría de Salud del Estado de Chihuahua

Email: bgumaro@hotmail.com

Phone: (614) 439-3300; Conm. 01(614) 439-9900 x.21518, 21656, 2158; 

Fax: (614) 415 2733; 

Cell (for emergency contact) 011-52-1-614-176-5900

Nuevo León

Dr. Jessica Suhail Sauceda Garza, Epidemióloga Estatal, Servicios de Salud del Estado de Nuevo León

Email: jsauceda@ssnl.gob.mx; drasauceda@hotmail.com

Phone: 01 (81) 83 61 00 58 and 95 directos

Coahuila

Dr. Juan Edmundo Salinas Aguirre, Epidemióloga Estatal, Secretaría de Salud del Estado de Coahuila

Email: epidemiologiaestatal@gmail.com; vigilancia-epi-coahuila@hotmail.com

Baja California

Dr. Néstor Saúl Hernández Millán, Epidemiólogo Estatal, Secretaría de Salud del Estado de Baja California

Email: nestorher.baja@gmail.com

Phone: P/F. (686) 5595 800 Ext.4252 (direct), 4251, 4253; Fax (686) 556 1059

Updated: May 2016
Operational Protocol for U.S.-Mexico Binational Communication and Coordination on Disease Notifications and Outbreaks

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Appendix 4: Template Terms of Reference for a Binational Outbreak 

Investigation

MEXICO-UNITED STATES BINATIONAL OUTBREAK INVESTIGATION OF [DISEASE], [LOCATION 

(STATE, COUNTRY)], [DATE]

Background

(Provide background with known information)

Collaborative Investigation Steps

1) Concurrence to conduct a binational investigation and to form a binational investigation team to investigate cases, 

confirm the diagnosis, determine the scale of the outbreak, identify significant risk factors, provide public health 

recommendations, and implement appropriate control measures as feasible. 

2) A binational oversight team of public health officials from both countries will meet by teleconference or in person 

to identify members of the Binational Field Investigation Team, including a lead from each country.

3) Team leads will 

a. Draft an investigation protocol, including the aims of the investigation, case definitions, and survey instruments

i. Anticipated aims are to:

1. Use data from both countries to characterize the outbreak of the apparent syndrome and possible risk 

factors

2. Identify the possible source of an outbreak in the community 

3. Implement control measures 

ii. Agree on a shared plan for reporting of the results of the investigation taking into consideration the mutual 

acceptance by both countries of the joint final report. 

iii. Agree on establishing a unique database for the investigation, accessible to binational team members.

b. Guide the team to initiate hypothesis generating interviews with cases 

c. Organize and provide assignments to binational teams, and assess response regularly to optimize investigation 

4) Identify necessary resources and explicitly indicate source of resources and how they will be shared. Resources to 

consider include:

a. Laboratory testing

b. Equipment

c. Travel

d. Staff

5) Explicitly indicate how information and updates will be shared. 

a. Binational team leads will provide regular progress reports to the binational field team during the course of the 

investigation

6) Identify terms for producing a timely joint report

a. Entities might agree upon binational publishing and clearance agreements

b. Establish joint authorship, including recognition of binational outbreak team participants for any publications
Operational Protocol for U.S.-Mexico Binational Communication and Coordination on Disease Notifications and Outbreaks

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Signature Page:

Federal: 

DGE ______________________________________________________________________________________

CDC ______________________________________________________________________________________

State Health Departments:

Mexico ____________________________________________________________________________________

United States ________________________________________________________________________________

Local Health Departments:

Mexico ____________________________________________________________________________________

United States ________________________________________________________________________________
Operational Protocol for U.S.-Mexico Binational Communication and Coordination on Disease Notifications and Outbreaks

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Appendix 5: Procedures for Sharing Laboratory Resources and Specimens 

During Public Health Events of Mutual Interest and Binational Outbreaks

Roles of laboratories in the United States and Mexico: Coordination, information exchange, 

and resource sharing.

Following the steps outlined in this document, proper channels of communication between authorized public health 

officials of the two countries will be established prior to any collaborative investigations of binational outbreaks. Again, 

unless otherwise stated, coordination of the investigation will be the responsibility of the legal public health authority 

where the outbreak is to be investigated.

If the investigation is going to be carried out in Mexico, some general considerations to be discussed may include:

w An invitation letter from, or an agreement with, the Mexican Federal Public Health authorities to a CDC subject 

matter expert (SME) to collaborate on a binational outbreak investigation in Mexican territory.

w A list of point of contacts of designated public health officers for coordination, necessary communication, and 

logistical support. 

w A schedule for case status follow-up calls can also be established, as needed. If laboratory specimens are to be 

exchanged or shipped, the contact list can also include laboratory points of contacts from both countries. 

w A list of needed laboratory supplies, reagents, controls, or other resources to facilitate critical laboratory testing in 

Mexico. List might contain list of items, quantities, and other resources, if needed. 

w A timeframe for shipment/delivery and final destination address for products.

w Availability of up-to-date required permits and estimated time required to obtain any new permits, if not available 

or expired.

w Written approval from the recipient to receive supplies or other resources. 

w Request for specific reference testing to be performed at CDC or other laboratories in the United States, including 

types of tests, numbers of specimens to be tested, and anticipated turnaround time for completion of tests.

w If specimens from Mexico are to be submitted for testing at CDC laboratories:

§ Approval from the CDC laboratory is required

§ Written guidance can be obtained for the type and quantity of each specimen to be tested and specimen 

handling guidelines.

§ It is recommended that the sender and recipient have continuous communication to establish dates/times of 

shipments, as well as planning and follow up for logistics before shipment is sent, and after it is received.

w If specimens or biologicals are sent from the United States to Mexico:

§ Specific information on the items to be sent to Mexico will be provided during initial discussions, including 

descriptions, quantities, and shipping instructions.

§ Necessary import and export permits will be obtained prior to shipping.

§ Mutual agreements will be made on timing of shipments and anticipated delivery and results dates.

Logistical and security requirements will be established prior to any exchange or deployment of resources to the 

investigation. Shipping logistics should be considered in the planning for delivery and receipt of products
Operational Protocol for U.S.-Mexico Binational Communication and Coordination on Disease Notifications and Outbreaks

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Appendix 6: List of Agencies and Organizations

ASPR – Assistant Secretary for Preparedness and Response

BIDS – Border Binational Infectious Disease Surveillance program

CDC – U.S. Centers for Disease Control and Prevention

CSTE – Council of State and Territorial Epidemiologists

DGE – Dirección General de Epidemiología (Directorate General of Epidemiology)

DGMQ – CDC’s Division of Global Migration and Quarantine

IHR – International Health Regulations 

PAHO – Pan American Health Organization

WHO – World Health Organization
Operational Protocol for U.S.-Mexico Binational Communication and Coordination on Disease Notifications and Outbreaks

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Appendix 7: Text Descriptions of Figures*

*This text is included for 508 website accessibility and not part of the Protocol content.

Page 13, Figure 3—Decision Tool for Confirming a Binational Outbreak And Initiating 

An Investigation

Top of chart begins with “Local, state, federal authorities detect greater than expected number of cases in jurisdiction.”

After authorities detect a greater than expected number of cases in jurisdiction, the questions to ask are: 

“Are the confirmed and probable cases of a condition included on the binationally notifiable list (see Appendix 2) 

and meet the binational case definition? (See table 1)”

OR

“Is the public health impact of the event serious? (See appendix 1 for a definition of a “serious case”)” “Is there 

significant risk of binational spread?”

1) If “No” to questions, then “Not a binational outbreak at this stage. Reassess as more information becomes 

available.”

2) If “Yes” to questions, then “Notifications to corresponding authorities, both formal and informal FYI (following the 

Communications Pathway Protocol).”

a. Then ask, “Based on state and federal input, will a binational call to review data be requested?”

i. If “No” “binational call will be requested to review data based on state and federal input,” then “Not a 

binational outbreak at this stage. Reassess as more information becomes available.”

ii. If “Yes” a “binational call will be requested to review data based on state and federal input,” then “CDC and 

DGE convene a binational call with relevant entities and counterparts.”

1) Next, “Binational group will evaluate data, determine if situation constitutes a binational outbreak, and 

decide whether a binational investigation should be initiated.” 

2) Continue through process beginning with “Notifications to corresponding authorities, both formal and 

informal FYI (following the Communications Pathways Protocol).”

During entire process, “Decisions, relevant data, and reports will be shared with corresponding authorities.”
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Page 20, Appendix 1—Annex 2: Decision Instrument for the Assessment and Notification of 

Events That May Constitute a Public Health Emergency of International Concern

Top of chart begins with: “Events detected by national surveillance system (see Annex 1)”

Events detected include:

1) “A case of the following diseases is unusual or unexpected and may have serious public health impact, and thus 

shall be notified (As per WHO case definitions, and the disease list shall be used only for the purposes of these 

Regulations): smallpox; poliomyelitis due to wild-type poliovirus; human influenza caused by a new subtype; severe 

acute respiratory syndrome (SARS).”

a. Then “Event shall be notified to WHO under the International Heath Regulations.”

OR

2) “Any event of potential international health concern, including those of unknown causes or sources and those 

involving other events or diseases than those listed in the box on the left and the box on the right shall lead to 

utilization of the algorithm.”

Then ask: “Is the public health impact of the event serious?”

1) If “Yes” then, “Is the event unusual or unexpected?”

a. If “Yes”, then “Event shall be notified to WHO under the International Heath Regulations.”

b. If “No”, then “Is there a significant risk of international spread?”

i. If “Yes”, then “Event shall be notified to WHO under the International Heath Regulations.”

ii. If “No”, then “Is there a significant risk of international travel or trade restrictions?”

1) If “Yes”, then “Event shall be notified to WHO under the International Heath Regulations.”

2) If “No”, then “Not notified at this stage. Reassess when more information becomes 

available.”

2) If “No”, then “Is the event unusual or unexpected?”

a. If “Yes”, then “Is there a significant risk of international spread?”

i. If “Yes”, then “Event shall be notified to WHO under the International Heath Regulations.”

ii. If “No”, then “Is there a significant risk of international travel or trade restrictions?”

1) If “Yes”, then “Event shall be notified to WHO under the International Heath Regulations.”

2) If “No”, then “Not notified at this stage. Reassess when more information becomes 

available.”

a. If “No”, then “Is there a significant risk of international spread?”

i. If “Yes”, then “Is there a significant risk of international travel or trade restrictions?”

1) If “Yes”, then “Event shall be notified to WHO under the International Heath Regulations.”

2) If “No”, then “Not notified at this stage. Reassess when more information becomes 

available.”

ii. If “No”, then “Not notified at this stage. Reassess when more information becomes available.”

OR

3) “An event involving the following diseases shall always lead to utilization of the algorithm, because they have 

demonstrated the ability to cause serious public health impact and to spread rapidly internationally (the disease 
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list shall be used only for the purposes of these Regulations): cholera; pneumonic plague, yellow fever, viral 

haemorrhagic fevers (Ebola, Lassa, Marburg); West Nile fever; Other diseases that are of special national or regional 

concern, e.g. dengue fever, Rift Valley fever, and meningococcal disease.”

Then ask: “Is the public health impact of the event serious?”

1) If “Yes” then, “Is the event unusual or unexpected?”

a. If “Yes”, then “Event shall be notified to WHO under the International Heath Regulations.”

b. If “No”, then “Is there a significant risk of international spread?”

i. If “Yes”, then “Event shall be notified to WHO under the International Heath Regulations.”

ii. If “No”, then “Is there a significant risk of international travel or trade restrictions?”

1) If “Yes”, then “Event shall be notified to WHO under the International Heath Regulations.”

2) If “No”, then “Not notified at this stage. Reassess when more information becomes 

available.”

2) If “No”, then “Is the event unusual or unexpected?”

a. If “Yes”, then “Is there a significant risk of international spread?”

i. If “Yes”, then “Event shall be notified to WHO under the International Heath Regulations.”

ii. If “No”, then “Is there a significant risk of international travel or trade restrictions?”

1) If “Yes”, then “Event shall be notified to WHO under the International Heath Regulations.”

2) If “No”, then “Not notified at this stage. Reassess when more information becomes 

available.”

b. If “No”, then “Is there a significant risk of international spread?”

i. If “Yes”, then “Is there a significant risk of international travel or trade restrictions?”

1) If “Yes”, then “Event shall be notified to WHO under the International Heath Regulations.”

2) If “No”, then “Not notified at this stage. Reassess when more information becomes 

available.”

ii. If “No”, then “Not notified at this stage. Reassess when more information becomes available.”