SAT Report

PMN Number: P-10-0005

SAT Date: 12/8/2009

Print Date: 12/2/2013

Related cases:

Concern levels:

Type of Concern: Health Eco Comments

Level of Concern: 2 1

 Persistence Bioaccum Toxicity Comments

3 31

Exposure Based Review:

Health: No

Ecotox: No

Routes of exposure: Health: Dermal Inhalation 

Ecotox: No releases to water

Fate: ;

Keywords:

 Keywords: LUNG, ONCO, IMMUNO

Summary of Assessment:

 Fate:

Fate Summary: P-10-0005

FATE: 

Solid 

S < 0.001 mg/L at 25 EC (E)

VP < 1.0E-6 torr at 25 EC (E)

BP > 400 EC (E)

H < 1.00E-8 (E)

POTW removal (%) = 0-90 via sorption

Time for complete ultimate aerobic biodeg > mo

Sorption to soils/sediments = low - v.strong
PBT Potential: P3B3

*CEB FATE: Migration to ground water = negl - rapid

Direct photolysis will be negl - rapid

Indirect photolysis will be negl - rapid

 Health:

 Health Summary: Absorption is poor all routes based on analogs. There is 

concern for lung toxicity if inhaled based on lung overload for poorly soluble particulates and 

concern for oncogenicity and immunotoxicity based on carbon nanotubes. Moderate concern.

 Ecotox:

Test Organism Test 

Type

Test End 

Point

Predicted Measured Comments

fish 96-h LC50 * * invalid effluent test

daphnid 48-h LC50 * * invalid effluent test

green algal 96-h EC50 *

fish _ chronic value *

daphnid _ chronic 

value

*

algal _ chronic 

value

*

Sewage Sludge 3-h EC50 _

Sewage Sludge _ Chronic 

Value

_

Ecotox Values Comments: Predictions are based on SARs for polynonionic polymers; SAR 

chemical class = polymer-nonionic-C84 nanotube; MW>10 000; log Kow >> 8 (P); solid with 

mp unk but S << 0.001 mg/L at 25 C (P); pH7; effective concentrations based on 100% active 

ingredients and nominal concentrations; hardness <150.0 mg/L as CaCO3; and TOC <2.0 

mg/L;

This PMN was submitted with two non-standard ecotoxicity tests with fish and daphnia. The 

tests are of plant effluents with only one concentration of effluent tested with the addition of a 

small amount of this single-walled carbon nanotube PMN. Conclusions are shown below. 

Details of the analysis are given in the attached spreadsheet.

These two assays were plant effluent tests rather than acute base-set tests and are inadequate to 

characterize the toxicity of this single-walled carbon nanotube (SWCNT) PMN. Specifically, 

they cannot be used to set surface water concern concentrations. Only one concentration of 

SWCNT was tested. Ceriodaphnia and fish (fathead minnows) were exposed separately for 7 

days to plant effluent at different dilutions (0, 0.5, 1, 5, 32%). An additional group consisted of 

5% effluent into which was mixed this SWCNT at a nominal loading concentration of 0.023%. 

The organisms showed no differences in effects (survival and growth for fish - survival and 

reproduction for daphnia) when exposed to 0.023% SWCNT in 5% effluent than when exposed 
to 5% effluent alone. No explanation of how SWCNTs were introduced into the effluent was 

given (e.g., mixing, sonication, use of solvents, filtering, etc.). In these two assays, no effects 

could be attributed to CNT. This is in agreement with ECOSAR predictions for nonionic 

polymers with physicochemical characteristics of this SWCNT. However, because these tests 

were so limited in their documentation and other major aspects, they are considered effectively 

invalid and ECOSAR predictions are relied upon to regulate this PMN.

Factors Values Comments

Assessment Factor 10

Concentration of Concern 

(ppb)

*

SARs nonionic polymers

SAR Class polymer-nonionic-carbon 

allotrope

Ecotox Category 

Ecotox Factors Comments: 

 SAT Chair: Becky Jones