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Section IX. 2022 Immunization Information Systems Annual Report (IISAR)

What is the Immunization Information Systems Annual Report (IISAR)?

The IISAR is an annual survey that assesses immunization program performance in developing, maintaining, and 

enhancing Immunization Information Systems for a given calendar year. It is a reporting requirement for the 64 

immunization programs that receive funding under section 317b of the Public Health Service Act.

A brief note on methods

• The IISAR is a self-reported, self-validated survey administered by the Centers for Disease Control and 

Prevention (CDC) and answered by immunization program awardees. CDC may contact you with questions after 

submission in order to continue data validation.

• Data are collected prior to the release of Census estimates for the year of the survey. For this reason, we include 

Census estimates in the survey for the year prior to provide preliminary estimates for some measures. These 

preliminary estimates are revised when the final Census data are released—approximately in September each 

year—for the prior years’ data. CDC provides preliminary estimates on the IISAR to ensure the estimates are 

concordant with the program and past years’ data. 

Changes in 2022

The IISAR underwent revisions in 2020 to align with the Data Quality Blueprint. The survey was reorganized to align with 

the blueprint milestones. Please be sure to carefully review the logic guidance in all sections in order to respond to their 

new specifications as accurately as possible.

• COVID-19 Inclusion Guidance: Awardees are instructed to include COVID-19 data in the 2022 IISAR. Awardees 

should:

o Include provider sites who have currently only submitted COVID-19 vaccination data

o Count any COVID-19 vaccinations toward patient participation counts

o Factor COVID-19 vaccinations into vaccine record timeliness calculations

o Respond “Yes” to questions about system functionality and activity, even if they were only deployed in 

the context of COVID-19 vaccines

• Monkeypox/Smallpox Vaccine Inclusion Guidance: With the 2022 outbreak of monkeypox and uptake of the 

JYNNEOS smallpox vaccine used to prevent and treat monkeypox, awardees are instructed to include

monkeypox/smallpox vaccine data in the 2022 IISAR. Awardees should:

o Include provider sites who have currently only submitted monkeypox/smallpox vaccination data

o Count any monkeypox/smallpox vaccinations toward patient participation counts

o Factor monkeypox/smallpox vaccinations into vaccine record timeliness calculations

o Respond “Yes” to questions about system functionality and activity, even if they were only deployed in 

the context of monkeypox/smallpox vaccines

• H1N1 Guidance Removed: To better streamline logic guidance in the IISAR, guidance pertaining to the exclusion 

criteria for the 2009 H1N1 pandemic have been removed. Though this guidance has been removed, awardees 

should:
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o Continue to exclude provider sites, if any, that only ever provided H1N1 vaccination data during the 

2009 pandemic

o Continue to exclude H1N1 vaccinations from patient participation calculations

Instructions

• All awardees that conduct IIS activities in their state/city/territory are required to complete this report.

• All awardees with IIS in transition are required to complete questions 1 through 5 and should consult with their 

IISSB Project Officer to discuss completing other data elements on the questionnaire. 

• Items in italics are completed by CDC; awardees only need to respond to questions that are NOT italicized. 

• Items reflect a range of topics involving the IIS’s live production environment. The production environment 

refers to your IIS being in operation and available for its intended use by its users.

• Throughout the IISAR questionnaire, age ranges are described as from age X through Y months/years. This 

terminology is consistent with language used by the Advisory Committee on Immunization Practices (ACIP) and 

indicates the lower and upper age limits for who should be included in data reporting. In all cases, age X is the 

lower bound and age Y is the upper bound. For example, adolescents aged 11 through 17 years should include 

adolescents at least 11 years old and less than 18 years of age. Those younger than 11 years, or 18 years or 

older, would not be included in this group.

• The IISAR questionnaire assesses several functionalities and activities of your IIS. Please note that questions 

utilizing the term “could” refer to capabilities of your system regardless of whether they were performed during 

the calendar year, while questions utilizing the term “did” refer to activities that your IIS actively performed 

during the calendar year.

• Submission of the final IISAR must be done by the Immunization Program Manager or their designee. 

• Only one Annual Report will be accepted per awardee. If awardees receive information from other regions or 

counties in their jurisdiction, the awardee must compile the information into one Annual Report. 

• The Annual Report is due on March 31, 2023; the year of performance is calendar year 2022. CDC IISSB staff will 

contact each IIS after March 31 with questions and/or comments about the report and data submitted for 

calendar year 2022. After March 31, 2023, the submission data will be corrected and revised. Any revised 

submissions from awardees should correct issues with the submitted data as of March 31 ONLY. When 

submitting revisions, do NOT submit additional 2022 data that were uploaded AFTER the March 31 cutoff date.

• Please contact Terence Ng, CDC/NCIRD/IISSB (contractor) at VFK5@cdc.gov or Lauren Shaw, CDC/NCIRD/IISSB at

ILV6@cdc.gov if you need clarification on a question or answer choice.

Resources

• For additional guidance on Patient Active/Inactive Status in Immunization Information Systems, see the AIRA 

guide here: http://repository.immregistries.org/files/resources/5835adc2dad8d/mirow_pais_full_guide.pdf

• For additional guidance on using dates to calculate a period of time, the Clinical Decision Support for 

Immunization (CDSi): Logic Specification for ACIP Recommendations can be referenced here: 

https://www.cdc.gov/vaccines/programs/iis/cdsi.html

• For additional guidance on IIS security, see the AIRA guide here: 

http://repository.immregistries.org/files/resources/595e4e25ab1b1/aira_security_guidance_-

_final_new_logo.pdf

• The Immunization Information Systems (IIS) Data Quality Blueprint is located here: 

https://www.cdc.gov/vaccines/programs/iis/downloads/Data-Quality-Blueprint-508.pdf
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CONTACT INFORMATION AND SCOPE OF IIS

Logic Guidance:

Q.1 – Q.5 are required to be completed by all awardees, including those with IIS in transition or temporarily inactive.

List ONLY government employee contacts in Q.3 and Q.4. 

1. Awardee_______________________

2. Name of person(s) submitting this report_______________________

3. Programmatic IIS contact person (a manager or administrator who coordinates IIS activities):

a. First Name: _______________________ e. Phone:________________ f. Ext: _______

b. Last Name: _______________________ g. Email:____________________________

c. Title: ____________________________

d. Affiliation:________________________

h. Check if contact person for questions about this report

4. Technical IIS contact person (coordinator of IIS software and/or hardware) :

Check if same as programmatic contact (if yes, autopopulate a-g)

a. First Name: _______________________ e. Phone:________________ f. Ext: _______

b. Last Name: _______________________ g. Email:____________________________

c. Title: ____________________________

d. Affiliation:________________________

h. Check if contact person for questions about this report

5. There is no IIS in production in this state/city/territory. (If yes, block out all subsequent sections of report)
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Age Groups

Logic Guidance: 

The IISAR has been programmed to match the age groups below. Some questions are only relevant for defined age 

groups. Therefore, the number of required questions may be reduced depending on which age groups are included in 

your IIS.

When determining if an age group is included in your IIS, consider the age range that your IIS is authorized to collect 

regardless of a reporting mandate or the completeness of data captured for that age group.

6. Which age groups are included in your IIS? Select one: 

a. Birth through 18 years of age

b. All ages, including adults

c. Other (specify)______________
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DATA QUALITY CHARACTERISTIC: COMPLETE

• 90% of all provider sites in the jurisdiction are reporting to the IIS

• 90% of demographic records for the jurisdiction are included in the IIS

• 90% of vaccination records for persons in the jurisdiction are included in the IIS

Provider Site Participation 

Logic Guidance— Provider Site Participation:

• Notes on Provider Site Classifications:

o Provider Site: A provider organization that provides vaccination services and that maintains permanent 

records (excluding temporary or mobile immunization clinics, health fairs, etc.).

o Enrolled: A provider site is considered enrolled if it is in your IIS and has achieved a live interface or is 

manually entering data to the IIS.

o All provider sites enrolled in VFC as of December 31, 2022 should be counted as a VFC site.

• Use the table below to identify provider sites to include in the assessment for Q.7 – 9.

General provider site inclusions/exclusions Include?

All provider sites enrolled in your IIS, regardless of age group served by those sites or your IIS YES

All provider sites enrolled in your IIS as of December 31, 2022 YES

Provider sites that are physically located outside your jurisdiction NO

 

Provider Sites

VFC Sites Non-VFC Sites

7. Number of provider sites in your jurisdiction as of December 31, 2022. a. --

8. Number of provider sites in your jurisdiction enrolled in your IIS as of 

December 31, 2022.

a. b.

9. Number of enrolled provider sites reporting data to your IIS at least once from 

July 1, 2022 – December 31, 2022.

a. b.

c. Percentage of VFC provider sites that reported data to your IIS at least 

once from July 1, 2022 – December 31, 2022. (auto-calculated) Q.9a/Q.7a

d. Percentage of all VFC provider sites and enrolled non-VFC provider sites 

that reported data to your IIS at least once from July 1, 2022 – December 

31, 2022. (auto-calculated) 

(Q.9a + Q.9b)/(Q.7a + Q.8b)
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Newborn Population Capture

Logic Guidance—Newborn Population Capture:

• Notes on Vital Records vs Other Records

o Vital Records: Vital Records are records of life events kept under governmental authority and include birth 

certificates.

o Other record: Other birth records are all other records of birth that are not Vital Records and may come 

from birthing hospitals, perinatal or newborn screening programs.

o Reported numbers of newborn records established from Vital Records and other record sources should be 

mutually exclusive.

o For Q.11 – Q.12 below, if a patient record comes to your IIS through other birth record sources, but is later 

verified by Vital Records, consider the patient record to have come from Vital Records.

o For Q.11 – Q.12 below, if a patient record comes to your IIS through other birth record sources ONLY, 

consider the patient record to have come from other record sources.

• Use the table below to identify newborns to include in the assessment:

Jurisdictional

Status

Age Residence Immunization History Include?

<any> Born 1/1/2022

through 

12/31/2022

Known to reside in 

jurisdiction at time 

of query, 

regardless of 

residence at time 

of birth

<any> Yes

Active Born 1/1/2022

through 

12/31/2022

Address in 

jurisdiction

<any> YES

Active Born 1/1/2022

through 

12/31/2022

Address unknown Received an immunization from a 

provider organization within the 

jurisdiction

YES

Unknown Born 1/1/2022

through 

12/31/2022

Address unknown IIS has never received vaccination 

information

YES

Unknown Born 1/1/2022

through 

12/31/2022

Address in 

jurisdiction 

OR

Address unknown

IIS has not received immunization 

information for an extended period of 

time*

* Note that the “extended period of 

time” could be defined differently by 

each IIS

YES
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Inactive Born 1/1/2022

through 

12/31/2022

Address not in 

jurisdiction

<any> NO

Deceased Born 1/1/2022

through 

12/31/2022

<any> <any> NO

<any> Born before 

1/1/2022 or after 

12/31/2022

<any> <any> NO

10. Number of children in the jurisdiction born from January 1 through December 31, 2022. (2021 Census data)

11. Number of patient records created in your IIS from Vital Records for children born from January 1 through December 

31, 2022 who resided in your jurisdiction at the time of query._____________

12. Number of patient records created in your IIS from sources other than Vital Records for children born from January 1 

through December 31, 2022 who resided in your jurisdiction at the time of query. _______________

a. Percentage of children in your IIS born from January 1 through December 31, 2022 with records created in 

your IIS from all sources. (Q.11+Q.12/Q.10)
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Enrollment in IIS (0–18 years, lifespan)

Logic Guidance—Enrollment among individuals aged 0 through 18 years:

• Q.14: For individuals 0 – 18 year of age

• Use the table below to identify individuals to include in the assessment:

Jurisdictional

Status

Age Residence Immunization History Include?

Active Born 1/1/2004

through 12/31/2022

Address in 

jurisdiction

<any> YES

Active Born 1/1/2004

through 12/31/2022

Address 

unknown

Received an immunization from a 

provider organization within the 

jurisdiction

YES

Unknown Born 1/1/2004

through 12/31/2022

Address 

unknown

IIS has never received vaccination 

information

YES

Unknown Born 1/1/2004

through 12/31/2022

Address in 

jurisdiction 

OR

Address 

unknown

IIS has not received immunization 

information for an extended period 

of time*

* Note that the “extended period of 

time” could be defined differently by 

each IIS

YES

Inactive Born 1/1/2004

through 12/31/2022

Address not in 

jurisdiction

<any> NO

Deceased Born 1/1/2004

through 12/31/2022

<any> <any> NO

<any> Born before 

1/1/2004 or after 

12/31/2022

<any> <any> NO

• After identifying individuals in the table above, use this table to further identify individuals to include in the 

assessment for Q.14:

General demographic inclusions/exclusions Include?

Individuals enrolled in your IIS, even if they only have travel vaccines, non-vaccine products, or no 

vaccines in the vaccine record

YES

13. Number of individuals aged 0 years through 18 years in the jurisdiction at the time of query. (2021 Census data) 

14. Number of individuals aged 0 years through 18 years (born from January 1, 2004 through December 31, 2022) in 

both your jurisdiction AND your IIS. __________
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a. 0–18 years enrollment: Percentage of individuals aged 0 years through 18 years in both your jurisdiction AND

your IIS. (Q.14/Q.13)

Logic Guidance—Enrollment among individuals of all ages:

• Q.16: For individuals of all ages

• Use the table below to identify individuals to include in the assessment:

Jurisdictional

Status

Age Residence Immunization History Include?

Active Born on or 

before 

12/31/2022

Address in 

jurisdiction

<any> YES

Active Born on or 

before 

12/31/2022

Address unknown Received an immunization from a 

provider organization within the 

jurisdiction

YES

Unknown Born on or 

before 

12/31/2022

Address unknown IIS has never received vaccination 

information

YES

Unknown Born on or 

before 

12/31/2022

Address in 

jurisdiction 

OR

Address unknown

IIS has not received immunization 

information for an extended period of 

time*

* Note that the “extended period of 

time” could be defined differently by 

each IIS

YES

Inactive Born on or 

before 

12/31/2022

Address not in 

jurisdiction

<any> NO

Deceased Born on or 

before 

12/31/2022

<any> <any> NO

<any> Born after 

12/31/2022

<any> <any> NO

• After identifying individuals in the table above, use this table to further identify individuals to include in the 

assessment for Q.16:

General demographic inclusions/exclusions Include?

Individuals enrolled in your IIS, even if they only have travel vaccines, non-vaccine products, or no 

vaccines in the vaccine record

YES
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15. Number of individuals of all ages in the jurisdiction at the time of query. (2021 Census data) 

16. Number of individuals of all ages (born on or before December 31, 2022) in both your jurisdiction AND your IIS. 

__________

a. Lifespan enrollment: Percentage of individuals of all ages in both your jurisdiction AND your IIS. (Q.16/Q.15)
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Child Participation in IIS (aged 4 months through 5 years)

Logic Guidance—Enrollment among children aged 4 months through 5 years:

• For Q.18:

• Use the table below to identify children to include in the enrollment assessment:

Jurisdictional

Status

Age Residence Immunization History Include?

Active Born 1/1/2017

through 

8/31/2022

Address in 

jurisdiction

<any> YES

Active Born 1/1/2017

through 

8/31/2022

Address unknown Received an immunization from a 

provider organization within the 

jurisdiction

YES

Unknown Born 1/1/2017

through 

8/31/2022

Address unknown IIS has never received vaccination 

information

YES

Unknown Born 1/1/2017

through 

8/31/2022

Address in 

jurisdiction 

OR

Address unknown

IIS has not received immunization 

information for an extended period of 

time*

* Note that the “extended period of 

time” could be defined differently by 

each IIS

YES

Inactive Born 1/1/2017

through 

8/31/2022

Address not in 

jurisdiction

<any> NO

Deceased Born 1/1/2017

through 

8/31/2022

<any> <any> NO

<any> Born before 

1/1/2017 or after 

8/31/2022

<any> <any> NO

• After identifying children in the table above, use this table to further identify children to include in the 

assessment for Q.18:

General demographic inclusions/exclusions Include?

Children enrolled in your IIS, even if they only have travel vaccines, non-vaccine products, or no 

vaccines in the vaccine record

YES
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17. Number of children aged 4 months through 5 years in the jurisdiction at the time of query. (2021 Census data) 

18. Number of children aged 4 months through 5 years (born from January 1, 2017 through Aug 31, 2022) in both your 

jurisdiction AND IIS at the time of query. __________

a. Child enrollment: Percentage of children aged 4 months through 5 years in both your jurisdiction AND IIS at 

the time of query. (Q.18/Q.17)

Logic Guidance—Participation among enrolled children aged 4 months through 5 years:

• For Q.19:

• After identifying children for enrollment in Q.18, use this table to further identify children with the following 

vaccinations for Q.19:

General vaccination inclusions/exclusions Include?

All doses (valid and invalid) administered before January 1, 2023, including those recorded in your 

IIS after December 31, 2022

YES

Travel vaccines (yellow fever, typhoid, etc.) See: http://wwwnc.cdc.gov/travel/page/yellowbookhome

NO

COVID-19 vaccines administered YES

Monkeypox/smallpox vaccines administered YES

Non-vaccine products (e.g. immune globulins, PPD) NO

19. Number of children in Q.18 (children born from January 1, 2017 through Aug 31, 2022 in both your jurisdiction AND 

IIS at the time of query) who have 2 or more vaccine doses recorded in your IIS. (Healthy People 2020 objective)

__________

a. Child participation: Percentage of children aged 4 months through 5 years in both your jurisdiction AND IIS at 

the time of query who have 2 or more vaccine doses recorded in your IIS. (Q.19/Q.17)
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Adolescent Participation in IIS (aged 11 through 17 years)

Logic Guidance—Enrollment among adolescents aged 11 through 17 years:

• For Q.21:

• Use the table below to identify adolescents to include in the enrollment assessment:

Jurisdictional

Status

Age Residence Immunization History Include?

Active Born 1/1/2005

through 

12/31/2011

Address in 

jurisdiction

<any> YES

Active Born 1/1/2005

through 

12/31/2011

Address unknown Received an immunization from a 

provider organization within the 

jurisdiction

YES

Unknown Born 1/1/2005

through 

12/31/2011

Address unknown IIS has never received vaccination 

information

YES

Unknown Born 1/1/2005

through 

12/31/2011

Address in 

jurisdiction 

OR

Address unknown

IIS has not received immunization 

information for an extended period of 

time*

* Note that the “extended period of 

time” could be defined differently by 

each IIS

YES

Inactive Born 1/1/2005

through 

12/31/2011

Address not in 

jurisdiction

<any> NO

Deceased Born 1/1/2005

through 

12/31/2011

<any> <any> NO

<any> Born before 

1/1/2005 or after 

12/31/2011

<any> <any> NO

• After identifying adolescents in the table above, use this table to further identify adolescents to include in the 

assessment for Q.21:

General demographic inclusions/exclusions Include?

Adolescents enrolled in your IIS, even if they only have travel vaccines, non-vaccine products, or 

no vaccines in the vaccine record

YES
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20. Number of adolescents aged 11 through 17 years in your jurisdiction at the time of query. (2021 Census data) 

21. Number of adolescents aged 11 through 17 years (born from January 1, 2005 through December 31, 2011) in both 

your jurisdiction AND IIS at the time of query. ______________

a. Adolescent enrollment: Percentage of adolescents aged 11 through 17 years in both your jurisdiction AND IIS 

at the time of query. (Q.21/Q.20)

Logic Guidance—Participation among enrolled adolescents aged 11 through 17 years:

• For Q.22:

• After identifying adolescents for enrollment in Q.21, use this table to further identify adolescents with the 

following vaccinations for Q.22:

General vaccination inclusions/exclusions Include?

All doses (valid and invalid) administered before January 1, 2023, including those recorded in your 

IIS after December 31, 2022

YES

Adolescent doses ONLY if they were administered from age 9 through 17 years. Only include: 

Tdap/Td, HPV, MenACWY, MenB, seasonal influenza, pneumococcal, HepA, HepB, polio, MMR, 

and varicella (http://www.cdc.gov/vaccines/schedules/hcp/child-adolescent.html#printable)

YES

COVID-19 vaccines administered YES

Monkeypox/smallpox vaccines administered YES

Doses administered to adolescents before the adolescent’s 9th birthday NO

Travel vaccines (yellow fever, typhoid, etc.) See: http://wwwnc.cdc.gov/travel/page/yellowbookhome

NO

Non-vaccine products (e.g. immune globulins, PPD) NO

22. Number of adolescents in Q.21 (adolescents born from January 1, 2005 through December 31, 2011 in both your 

jurisdiction AND IIS at the time of query) who have 2 or more adolescent vaccine doses administered from age 9 

through 17 years recorded in your IIS? (Healthy People 2020 objective). ______________

a. Adolescent participation: Percentage of adolescents aged 11 through 17 years in both your jurisdiction AND 

IIS at the time of query who have 2 or more adolescent vaccine doses recorded in your IIS. (Q.22/Q.20)
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Adult Participation in IIS (aged 19 years and older)

Logic Guidance—Enrollment among adults aged 19 years and older:

• For Q.24:

• Use the table below to identify adults to include in the enrollment assessment:

Jurisdictional

Status

Age Residence Immunization History Include?

Active Born on or 

before 

12/31/2003

Address in 

jurisdiction

<any> YES

Active Born on or 

before 

12/31/2003

Address unknown Received an immunization from a 

provider organization within the 

jurisdiction

YES

Unknown Born on or 

before 

12/31/2003

Address unknown IIS has never received vaccination 

information

YES

Unknown Born on or 

before 

12/31/2003

Address in 

jurisdiction 

OR

Address unknown

IIS has not received immunization 

information for an extended period of 

time*

* Note that the “extended period of 

time” could be defined differently by 

each IIS

YES

Inactive Born on or 

before 

12/31/2003

Address not in 

jurisdiction

<any> NO

Deceased Born on or 

before 

12/31/2003

<any> <any> NO

<any> Born after 

12/31/2003

<any> <any> NO

• After identifying adults in the table above, use this table to further identify adults to include in the assessment 

for Q.24:

General demographic inclusions/exclusions Include?

Adults enrolled in your IIS, even if they only have travel vaccines, non-vaccine products, or no 

vaccines in the vaccine record

YES
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23. Number of adults aged 19 years and older in your jurisdiction at the time of query. (2021 Census data) 

24. Number of adults aged 19 years and older (born on or before December 31, 2003) in both your jurisdiction AND IIS 

at the time of query. ___________

a. Adult enrollment: Percentage of adults aged 19 years and older in both your jurisdiction AND IIS at the time

of query. (Q.24/Q.23)

Logic Guidance—Participation among enrolled adults aged 19 years and older:

• For Q.25:

• After identifying adults for enrollment in Q.24, use this table to further identify adults with the following 

vaccinations for Q.25:

General vaccination inclusions/exclusions Include?

All doses (valid and invalid) administered before January 1, 2023, including those recorded in your 

IIS after December 31, 2022

YES

Adult doses ONLY if they were administered from age 19 years and older. Only include: seasonal 

influenza, Tdap/Td, varicella, HPV, zoster, MMR, pneumococcal, MenACWY, MenB, HepA, and 

HepB https://www.cdc.gov/vaccines/schedules/downloads/adult/adult-combined-schedule.pdf

YES

COVID-19 vaccines administered YES

Monkeypox/smallpox vaccines administered YES

Doses administered to adults before 19 years of age NO

Travel vaccines (yellow fever, typhoid, etc.) See: http://wwwnc.cdc.gov/travel/page/yellowbookhome

NO

Non-vaccine products (e.g. immune globulins, PPD) NO

25. Number of adults in Q.24 (born on or before December 31, 2003 in both your jurisdiction AND IIS at the time of 

query) who have 1 or more adult vaccine dose(s) administered at 19 years and older recorded in your 

IIS._____________

a. Adult participation: Percentage of adults aged 19 years and older in both your jurisdiction AND IIS at the time 

of query who have 1 or more adult vaccine dose(s) recorded in your IIS. (Q.25/Q.23)

26. Within the last six months of 2022, did your IIS assess the number of publicly-funded vaccines delivered AND the 

number of publicly-funded vaccines administered in your IIS using IIS vaccine inventory functionality? Yes/No

Notes for BLUEPRINT: COMPLETE Please provide any relevant notes or comments for data provided in for 

this section
17
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DATA QUALITY CHARACTERISTIC: VALID

• 100% of routine age-based vaccines in the IIS are evaluated and forecasted in alignment with ACIP 

recommendations

• 100% of patient addresses are validated using external sources

Address Validation

27. In 2022, were residential addresses verified to ensure a patient currently resided at the address listed in the patient 

record? Yes/No

28. In 2022, were residential addresses standardized and validated as USPS addresses? Yes/No

Notes for BLUEPRINT: VALID Please provide any relevant notes or comments for data provided in for 

this section
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DATA QUALITY CHARACTERISTIC: TIMELY

• 95% of birth records are created in the IIS within 30 days of the patient’s birth

• 95% of vaccination events are recorded in the IIS within 1 day

Timeliness of Birth Records in IIS

Logic Guidance—Birth Record Timeliness:

• Notes on Days:

o Day 0 refers to the date of birth.

o Days listed refer to calendar days.

• Notes on Vital Records versus Other Records

o Vital Records: Vital Records are records of life events kept under governmental authority and include birth 

certificates.

o Other record: Other birth records are all other records of birth that are not Vital Records and may come 

from birthing hospitals, perinatal or newborn screening programs.

o Reported numbers of newborn records established from Vital Records and other record sources should be 

mutually exclusive.

o When determining whether a record was established by Vital Records or other birth record sources, 

consider which source the birth record was established by first. Therefore, regardless of whether a birth 

record is later established by Vital Records, if it was first established by Other Record sources, consider it 

established by Other Record Sources. Only consider a record established by Vital Records if it was 

established in your IIS by Vital Records FIRST.

• Use the table below to identify newborns to include in the assessment:

Jurisdictional

Status

Age Residence Immunization History Include?

Active Born 1/1/2022

through 

12/31/2022

Address in 

jurisdiction

<any> YES

Active Born 1/1/2022

through 

12/31/2022

Address 

unknown

Received an immunization from a provider 

organization within the jurisdiction

YES

Unknown Born 1/1/2022

through 

12/31/2022

Address 

unknown

IIS has never received vaccination 

information

YES

Unknown Born 1/1/2022

through 

12/31/2022

Address in 

jurisdiction 

OR

Address 

unknown

IIS has not received immunization 

information for an extended period of time*

* Note that the “extended period of time” 

could be defined differently by each IIS

YES

Inactive Born 1/1/2022

through 

12/31/2022

Address not 

in jurisdiction

<any> NO
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Deceased Born 1/1/2022

through 

12/31/2022

<any> <any> NO

<any> Born before 

1/1/2022 or after 

12/31/2022

<any> <any> NO

29. For children born January 1 through December 31, 2022 in your IIS’s jurisdiction, what number had a demographic 

record established in your IIS within the following days after birth:

a. Number of children with 

record established from 

Vital Records

b. Number of children with 

record established from 

sources other than Vital 

Records

Percentage of children with 

records established in the 

specified timeframe (autocalculated)

≤30 days a. b. c. (a+b)/(j+k)

>30 days - ≤60 days d. e. f. (d+e)/(j+k)

>60 days g. h. i. (g+h)/(j+k)

Total (auto-calculated) j.-- k.--
21

Timeliness of Vaccination Records in IIS

Logic Guidance—Vaccine Record Timeliness:

• Notes on timeliness:

o The period of timeliness corresponds to the time between the date of administration of the vaccine dose 

indicated on the vaccination record and the date the vaccination record was posted to production in your 

IIS.

o Timeframes listed refer to calendar days.

• Use the table below to identify individuals to include in the assessment:

Jurisdictional

Status

Age Residence Immunization History Include?

Active For 0 – 18 year olds:

Born 1/1/2004

through 12/31/2022

For All Ages:

Born 12/31/2022 or 

earlier

Address in 

jurisdiction

<any> YES

Active For 0 – 18 year olds:

Born 1/1/2004

through 12/31/2022

For All Ages:

Born 12/31/2022 or 

earlier

Address 

unknown

Received an immunization from a 

provider organization within the 

jurisdiction

YES

Unknown For 0 – 18 year olds:

Born 1/1/2004

through 12/31/2022

For All Ages:

Born 12/31/2022 or 

earlier

Address 

unknown

IIS has never received vaccination 

information

NO

Unknown For 0 – 18 year olds:

Born 1/1/2004

through 12/31/2022

For All Ages:

Born 12/31/2022 or 

earlier

Address in 

jurisdiction 

OR

Address 

unknown

IIS has not received immunization 

information for an extended period of 

time*

YES
22

* Note that the “extended period of 

time” could be defined differently by 

each IIS

Inactive For 0 – 18 year olds:

Born 1/1/2004

through 12/31/2022

For All Ages:

Born 12/31/2022 or 

earlier

Address not in 

jurisdiction

<any> NO

Deceased For 0 – 18 year olds:

Born 1/1/2004

through 12/31/2022

For All Ages:

Born 12/31/2022 or 

earlier

<any> <any> NO

<any> For 0 – 18 year olds:

Born 1/1/2004

through 12/31/2022

For All Ages:

Born 12/31/2022 or 

earlier

<any> <any> NO

• After identifying individuals in the table above, use this table to determine the appropriate vaccination records 

to include in the assessment:

General vaccination inclusions/exclusions Include?

For 0 – 18 year olds: Vaccinations administered in CY2022 for all persons 0 – 18 years in your IIS

For All Ages: Vaccinations administered in CY2022 for persons of all ages in your IIS

YES

Doses that were administered before January 1, 2023, including those recorded after December 

31, 2022

YES

All doses (valid and invalid) YES

COVID-19 vaccines administered YES

Monkeypox/smallpox vaccines administered YES

Travel vaccines (yellow fever, typhoid, etc.) See: http://wwwnc.cdc.gov/travel/page/yellowbookhome NO
23

Historical vaccinations (vaccination information submitted to your IIS by a provider who did not 

administer that vaccination) NO

Non-vaccine products (e.g. immune globulins, PPD) NO

30. For vaccinations administered in 2022 to all persons 0 – 18 years and of all ages in your IIS, list the number of vaccine 

doses posted to production to your IIS within the following time frames:

Number of vaccine 

doses administered 

(i.e. non-historical) 

during CY2022 to 

persons aged 0 

through 18 years

Percentage of doses 

reported for persons 

aged 0 through 18 

years for the specified 

timeframe (autocalculated)

Number of vaccine 

doses administered to 

persons of all ages 

(lifespan) (i.e. nonhistorical) during 

CY2022

Percentage of doses 

reported for persons 

of all ages (lifespan) 

for the specified 

timeframe (autocalculated)

≤1 days a f (a/e) j o (j/n)

>1 days–

≤14 days

b g (b/e) k p (k/n)

>14 days–

≤30 days

c h (c/e) l q (l/n)

>30 days d i (d/e) m r (m/n)

Total 

(autocalculated)

e n

Notes for BLUEPRINT: TIMELY Please provide any relevant notes or comments for data provided in for 

this section
24

DATA QUALITY CHARACTERISTIC: AVAILABLE

• Immunization program staff have the ability to query IIS data for coverage reports and ad hoc questions

Reporting Capability

31. In 2022, were IIS data used to generate population-based coverage assessments for provider sites by patient age, 

age group, single vaccine, vaccine series, geographic sub-jurisdiction-level areas, OR other characteristics and 

published in a report that was shared with providers or other stakeholders within the jurisdiction? Yes/No

32. In 2022, were IIS data used to generate population-based coverage assessments by patient age, age group, single 

vaccine, vaccine series, geographic sub-jurisdiction-level areas, OR other characteristics and published to a public 

facing website? Yes/No

a. If yes, please provide website link: _____________________________

33. In 2022, was your IIS used to generate provider-level coverage assessments that met current published CDC 

operational and technical guidelines for provider-level quality improvement? Yes/No

34. In 2022, did IIS staff produce IIS-generated provider-level coverage assessments based on user-selected criteria? 

Yes/No

35. In 2022, did non-IIS immunization program staff (VFC coordinators, IQIP coordinators, etc.) produce IIS-generated 

provider-level coverage assessments based on user-selected criteria? Yes/No

36. In 2022, could providers produce IIS-generated coverage assessments based on user-selected criteria? Yes/No

37. In 2022, did your IIS generate vaccination coverage assessments for geographic sub-jurisdiction-level areas (e.g. 

county, ZIP code, region, etc.) to identify under-immunized populations? Yes/No

38. In 2022, could your IIS generate data for health plans to support HEDIS reports based on query parameters (e.g. a 

patient age group/DOB range, list of specific individuals, geographic area, recipients of specific vaccines, etc.)?

Yes/No

39. In 2022, was your IIS used to generate data to support Medicaid and/or Medicare quality improvement based on 

user-selected parameters? Yes/No

Notes for BLUEPRINT: AVAILABLE Please provide any relevant notes or comments for data provided in for 

this section
25

DATA QUALITY CHARACTERISTIC: ACCURATE

Patient Status Assignation

40. In 2022, did your IIS assign patient status when receiving an inactive flag or notification from an EHR at the 

jurisdiction level? Yes/No

41. In 2022, did your IIS assign patient status when receiving an inactive flag or notification from an EHR at the provider

level? Yes/No
26

Data Elements – Patient Status Indicators

Logic Guidance— Data Elements—Patient Status Indicators for individuals aged 0 – 18 years:

• Use the table below to identify individuals to include in the assessment:

Jurisdictional

Status

Age Residence Immunization History Include?

Active Born 1/1/2004

through 

12/31/2022

Address in 

jurisdiction

<any> YES

Active Born 1/1/2004

through 

12/31/2022

Address 

unknown

Received an immunization from a provider 

organization within the jurisdiction

YES

Unknown Born 1/1/2004

through 

12/31/2022

Address 

unknown

IIS has never received vaccination 

information

YES

Unknown Born 1/1/2004

through 

12/31/2022

Address in 

jurisdiction 

OR

Address 

unknown

IIS has not received immunization 

information for an extended period of time*

* Note that the “extended period of time” 

could be defined differently by each IIS

YES

Inactive Born 1/1/2004

through 

12/31/2022

Address not 

in jurisdiction

<any> NO

Deceased Born 1/1/2004

through 

12/31/2022

<any> <any> NO

<any> Born before 

1/1/2004 or after 

12/31/2022

<any> <any> NO

Patient-level data elements Field Status (check one)

Number of patient records with 

date of birth from January 1, 2004

through December 31, 2022, with 

field populated with data

Percentage of patient records 

with date of birth from January 

1, 2004 through December 31, 

2022 with field populated with 

data. Denominator from Q.14

(auto-calculated)

42. Patient status indicators 

at the provider site 

level: 

Definition: A field to denote 

the status of a patient. 

Examples: 

• Active

• Inactive – No longer a 

patient

• Inactive – Lost to followup

• Inactive – Unspecified

• Deceased

a.  Field present 

 No field b. # c. Q.42b/Q.14
27

NOTE: If the patient has 

more than one patient status 

indicator in your IIS (e.g. for 

multiple provider sites), 

include the patient in the 

numerator if they have at 

least one active or inactive 

status indicated in their 

record.

If your IIS cannot assign 

active status and only assigns 

inactive or deceased status, 

do not count the field as 

present.

43. In 2022, did your IIS generate a roster of active patients for a provider site from your IIS? Yes/No

44. In 2022, could your IIS assign deceased status to an individual based on information from vital statistics? Yes/No
28

4:3:1:3:3:1:4 Series Coverage (for children aged 19 through 35 months) 

Logic Guidance—Child Immunization Coverage in IIS:

• Notes on Coverage:

o Coverage is defined as the number of individuals in a certain age group who received a vaccination(s) 

divided by the Census-based estimate of persons in that age group in your jurisdiction. Jurisdiction is 

defined as the area that contains the population of individuals residing in geographic location covered by 

your IIS.

• For Q.46: 

• Use the table below to identify children to include in the assessment:

Jurisdictional

Status

Age Residence Immunization History Include?

Active Born 1/1/2020

through 

5/31/2021

Address in 

jurisdiction

<any> YES

Active Born 1/1/2020

through 

5/31/2021

Address 

unknown

Received an immunization from a provider 

organization within the jurisdiction

YES

Unknown Born 1/1/2020

through 

5/31/2021

Address 

unknown

IIS has never received vaccination 

information

NO

Unknown Born 1/1/2020

through 

5/31/2021

Address in 

jurisdiction 

OR

Address 

unknown

IIS has not received immunization 

information for an extended period of time*

* Note that the “extended period of time” 

could be defined differently by each IIS

YES

Inactive Born 1/1/2020

through 

5/31/2021

Address not 

in jurisdiction

<any> NO

Deceased Born 1/1/2020

through 

5/31/2021

<any> <any> NO

<any> Born before 

1/1/2020 or after 

5/31/2021

<any> <any> NO

• After identifying children using the tables above, use this table to further identify children with the following 

vaccinations for Q.46:

General vaccination inclusions/exclusions Include?

Both valid and invalid doses. YES

Doses administered before January 1, 2023, including those recorded after December 31, 2022 YES
29

The 4:3:1:3:3:1:4 series includes 4 or more DTaP/DTP/DT, 3 or more Polio, 1 or more MMR, 3 or 

more Hepatitis B, ≥3 or ≥4 of Hib*, 1 or more Varicella†, and 4 or more pneumococcal containing 

vaccine).

*When calculating Hib doses, include children who received 4+ Hib-containing vaccine doses 

(includes any type of Hib vaccine, including Hib, unspecified formulation) or 2 Hib-OMP doses 

(manufactured by Merck; includes PedVaxHib and Comvax) followed by ≥1 Hib dose of any type. 

† When counting Varicella, only include those who received 1 or more dose of Varicella. Do not 

count history of disease.

YES

All Doses

45. Number of children aged 19 through 35 months in your jurisdiction at the time of query.

(2021 Census data)

--

46. Number of children born during January 1, 2020 through May 31, 2021 in both your 

jurisdiction AND IIS at the time of query who have received the complete 4:3:1:3:3:1:4 

series?

a. Coverage – percentage of children aged 19 through 35 months in the population who 

have completed the 4:3:1:3:3:1:4 series. (Q.46/Q.45)

Q.46/Q.45

(Autocalculated)
30

4:3:1:3:3:1:4 Series Coverage (for children born 2019 – 2020) 

Logic Guidance— Child Immunization Coverage in IIS—2 year olds:

• Notes on Coverage:

o Coverage is defined as the number of individuals in a certain age group who received a vaccination(s) 

divided by the Census-based estimate of persons in that age group in your jurisdiction. Jurisdiction is 

defined as the area that contains the population of individuals residing in geographic location covered by 

the IIS.

• Q.49: 

• Use the appropriate age ranges listed above and the table below to identify children to include in the assessment:

Jurisdictional

Status

Age Residence Immunization History Include?

Active Born 1/1/2019

through 

12/31/2020

Address in 

jurisdiction

<any> YES

Active Born 1/1/2019

through 

12/31/2020

Address 

unknown

Received an immunization from a provider 

organization within the jurisdiction

YES

Unknown Born 1/1/2019

through 

12/31/2020

Address 

unknown

IIS has never received vaccination 

information

NO

Unknown Born 1/1/2019

through 

12/31/2020

Address in 

jurisdiction 

OR

Address 

unknown

IIS has not received immunization 

information for an extended period of time*

* Note that the “extended period of time” 

could be defined differently by each IIS

YES

Inactive Born 1/1/2019

through 

12/31/2020

Address not 

in jurisdiction

<any> NO

Deceased Born 1/1/2019

through 

12/31/2020

<any> <any> NO

<any> Born before 

1/1/2019 or after 

12/31/2020

<any> <any> NO

• After identifying children using the tables above, use this table to further identify children with the following 

vaccinations for Q.49:

General vaccination inclusions/exclusions Include?

Both valid and invalid doses. YES

Doses administered before January 1, 2023, including those recorded after December 31, 2022 YES

Doses administered on or after the child’s 2nd birthday NO
31

The 4:3:1:3:3:1:4 series includes 4 or more DTaP/DTP/DT, 3 or more Polio, 1 or more MMR, 3 or 

more Hepatitis B, ≥3 or ≥4 of Hib*, 1 or more Varicella†, and 4 or more pneumococcal containing 

vaccine).

*When calculating Hib doses, include children who received 4+ Hib-containing vaccine doses 

(includes any type of Hib vaccine, including Hib, unspecified formulation) or 2 Hib-OMP doses 

(manufactured by Merck; includes PedVaxHib and Comvax) followed by ≥1 Hib dose of any type. 

† When counting Varicella, only include those who received 1 or more dose of Varicella. Do not 

count history of disease.

YES

 

All Doses

47. Number of children born in 2019 and 2020. (2021 Census data) --

48. NIS 4:3:1:3:3:1:4 series coverage percentage for children born in 2019-2020 who have 

received complete 4:3:1:3:3:1:4 series before they reached 24 months of age. (2021 NIS 

data for 2018 – 2019)

--

49. Number of children born during January 1, 2019 through December 31, 2020 in both your 

jurisdiction AND IIS at the time of query who have received the complete 4:3:1:3:3:1:4 

series before they reached 24 months of age?

a. Coverage – percentage of children born in 2019 – 2020 in the population who have 

completed the 4:3:1:3:3:1:4 series before reaching 24 months of age. (Q.49/Q.47)

(Q.49)/(Q.47)

(Autocalculated)

b. IIS Point Estimate Difference – NIS — IIS 4:3:1:3:3:1:4 series coverage percentage 

minus NIS 4:3:1:3:3:1:4 series coverage percentage. (Q.49a – Q.48)

Q.49a – Q.48

(Autocalculated)
32

Adolescent Immunization Coverage (for adolescents aged 13 through 17 years) 

Logic Guidance—Adolescent Immunization Coverage in IIS:

• Notes on Coverage:

o Coverage is defined as the number of individuals in a certain age group who received a vaccination(s) 

divided by the Census-based estimate of persons in that age group in your jurisdiction. Jurisdiction is 

defined as the area that contains the population of individuals residing in geographic location covered by 

your IIS.

• For Q.52:

• Use the table below to identify adolescents to include in the assessment:

Jurisdictional

Status

Age Residence Immunization History Include?

Active Born 1/1/2005

through 

12/31/2009

Address in 

jurisdiction

<any> YES

Active Born 1/1/2005

through 

12/31/2009

Address 

unknown

Received an immunization from a provider 

organization within the jurisdiction

YES

Unknown Born 1/1/2005

through 

12/31/2009

Address 

unknown

IIS has never received vaccination 

information

NO

Unknown Born 1/1/2005

through 

12/31/2009

Address in 

jurisdiction 

OR

Address 

unknown

IIS has not received immunization 

information for an extended period of time*

* Note that the “extended period of time” 

could be defined differently by each IIS

YES

Inactive Born 1/1/2005

through 

12/31/2009

Address not 

in jurisdiction

<any> NO

Deceased Born 1/1/2005

through 

12/31/2009

<any> <any> NO

<any> Born before 

1/1/2005 or after 

12/31/2009

<any> <any> NO

• After identifying adolescents using the tables above, use this table to further identify adolescents with the 

following vaccinations for Q.52:

General vaccination inclusions/exclusions Include?

Both valid and invalid doses. YES

Tdap/Td vaccines, including those labeled as “unspecified” YES
33

Any DT/DTP/DTaP-containing vaccines* given at or after age 7 years, including those labeled as 

“unspecified”

*Doses reported as DT/DTP/DTaP-containing that were administered at or after age 7 years could 

reflect misreported Tdap doses. DTaP that has been misadministered at age 7 years or older may 

also be counted toward adolescent Tdap. 

YES

Any undeterminable DT/DTP/DTaP/Tdap/Td-labeled dose* given at or after age 7 years, BUT 

before the adolescent’s 18th birthday AND before January 1, 2023

*“Undeterminable DT/DTP/DTaP/Tdap/Td” is a specific label used by some IIS to indicate doses 

where the contents of the dose regarding DT, DTP, DTaP, Tdap, or Td were not specified in the 

documentation. Doses reported under this label of “undeterminable DT/DTP/DTaP/Tdap/Td” that 

were administered at or after age 7 years could reflect misreported Tdap doses. If your IIS does 

not use the “undeterminable DT/DTP/DTaP/Tdap/Td” label, disregard this logic guidance.

YES

Doses administered before January 1, 2023, including those recorded after December 31, 2022 YES

Doses administered on or after the adolescent’s 18th birthday NO

 

All Doses

50. Number of adolescents aged 13 through 17 years in your jurisdiction at the time of query.

(2021 Census data)

--

51. NIS Tdap/Td coverage percentage for adolescents aged 13 through 17. (2021 NIS data) --

52. Number of adolescents aged 13 through 17 years (born from January 1, 2005 through 

December 31, 2009) who are in both in your jurisdiction at the time of query AND in your IIS 

who have at least one dose of Tdap/Td? 

a. Coverage — Percentage of adolescents aged 13 through 17 years in the population 

who have at least one dose of Tdap/Td. (Q.52/Q.50)

Q.52/Q.50

(Autocalculated)

b. IIS Point Estimate Difference – NIS — IIS Tdap/Td coverage percentage minus NIS 

Tdap/Td coverage percentage. (Q.52a – Q.51)

Q.52a – Q.51

(Autocalculated)
34

Adult Influenza Coverage (aged 18 and older)

Logic Guidance—Adult Influenza Coverage in IIS:

• Notes on Coverage:

o Coverage is defined as the number of individuals in a certain age group who received a vaccination(s) 

divided by the Census-based estimate of persons in that age group in your jurisdiction. Jurisdiction is 

defined as the area that contains the population of individuals residing in geographic location covered by 

your IIS.

• Q.55: 

• Use the table below to identify adults to include in the assessment:

Jurisdictional

Status

Age Residence Immunization History Include?

Active Born on or 

before 

12/31/2004

Address in 

jurisdiction

<any> YES

Active Born on or 

before 

12/31/2004

Address 

unknown

Received an immunization from a provider 

organization within the jurisdiction

YES

Unknown Born on or 

before 

12/31/2004

Address 

unknown

IIS has never received vaccination 

information

NO

Unknown Born on or 

before 

12/31/2004

Address in 

jurisdiction 

OR

Address 

unknown

IIS has not received immunization 

information for an extended period of time*

* Note that the “extended period of time” 

could be defined differently by each IIS

YES

Inactive Born on or 

before 

12/31/2004

Address not 

in jurisdiction

<any> NO

Deceased Born on or 

before 

12/31/2004

<any> <any> NO

<any> Born after 

12/31/2004

<any> <any> NO

• After identifying adults using the tables above, use this table to further identify adults with the following 

vaccinations for Q.55:

General vaccination inclusions/exclusions Include?

Both valid and invalid doses YES

Doses of adult influenza administered on or after July 1, 2021 through May 31, 2022 YES

Doses administered before June 1, 2022, including those recorded after May 31, 2022 YES
35

Doses administered at any time on or after the adult’s 18th birthday YES

Doses of influenza administered to a patient during the 2021 – 2022 flu vaccination season before

the patient’s 18th birthday YES

 

All Doses

53. Number of adults 18 years or older in your jurisdiction at the time of query. (2021 Census 

data)

--

54. BRFSS influenza coverage percentage for adults 18 years or older. (2020 – 2021 BRFSS data) --

55. Number of adults aged 18 years or older (born on or before December 31, 2004) in both 

your jurisdiction AND IIS at the time of query who have at least one dose of adult influenza 

vaccine administered during the 2021 – 2022 flu vaccination season (July 1, 2021 – May 31, 

2022) at the age of 18 or older? 

a. Coverage — Percentage of adults aged 18 years or older who have at least one dose 

of adult influenza administered during the 2021 – 2022 flu vaccination season (July 

1, 2021 – May 31, 2022). (Q.55/Q.53)

Q.55/Q.53

(Autocalculated)

b. IIS Point Estimate Difference – BRFSS — IIS influenza coverage percentage minus 

BRFSS influenza coverage percentage. (Q.55a – Q.54)

Q.55a – Q.54

(Autocalculated)

Notes for BLUEPRINT: ACCURATE Please provide any relevant notes or comments for data provided in for 

this section
36

DATA QUALITY CHARACTERISTIC: UNIQUE

Records Management

56. In 2022, did your IIS assess the number of records that require manual resolution after the automated matching 

process? Yes/No

Logic Guidance:

For Q.57 & Q.58:

“Routinely” is defined as “on a set schedule as part of regular operating procedures”.

57. In 2022, did your IIS routinely assess the time to perform manual data resolution of records? Yes/No

58. In 2022, did your IIS routinely assess the percentage of duplicates in the system? Yes/No

Notes for BLUEPRINT: UNIQUE Please provide any relevant notes or comments for data provided in for 

this section
37

DATA QUALITY CHARACTERISTIC: ADDITIONAL DATA

Onboarding Status

Logic Guidance 

Q.59:

• Provider Site: A provider organization that provides vaccination services and that maintains permanent records 

(excluding temporary or mobile immunization clinics, health fairs, etc.).

• Count physical sites, not individual providers.

• If multiple provider sites report through a single portal, count each provider site separately. 

• Count each provider site only once in the table. 

• “Connected with your IIS” is defined as using any of the methods listed in the columns in the table below.

59. Indicate the TOTAL number of provider sites connected with your IIS in production as of the end of 2022. 

HL7 2.5.1 r1.5 Other than HL7 2.5.1 r1.5 (including non-HL7) Total (autocalculated)

Both 

Submission/

Acknowledgement and 

Query/

Response 

Submission/

Acknowledgement only

Query/

Response only

Both 

Submission/

Acknowledgement and 

Query/

Response 

Submission/

Acknowledgement only

Query/

Response only

Mediated 

by a Health 

Information 

Exchange

a. b. c. d. e. f. g. 

(a+b+c+d+e+

f)

Not 

mediated 

by a Health 

Information 

Exchange

h. i. j. k. l. m. n. 

(h+i+j+k+l+m

)

TOTAL o. (a+h) p. (b+i) q. (c+j) r. (d+k) s. (e+l) t. (f+m)
38

Logic Guidance 

Q.60:

• Provider Site: A provider organization that provides vaccination services and that maintains permanent 

records (excluding temporary or mobile immunization clinics, health fairs, etc.).

• Registered intent refers to provider sites that have indicated their intention to onboard, but have not 

yet started the testing process. Only include sites that intend to onboard through Meaningful Use.

• Count physical sites, not individual providers. 

• If multiple provider sites report through a single portal, count each provider site separately. 

• Count each provider site only once in the table.

• Count both immunizing and non-immunizing provider sites that your IIS intends to move to production 

or that are already in production.

60. Indicate the TOTAL number of provider sites in each onboarding category as of the end of 2022. 

Onboarding 

Category

Both

Submission/Acknowledgement 

and Query/Response 

Submission/Acknowledgement 

only

Query/Response only

Registered intent, 

and are not testing 

or in production

a. b. c.

Currently testing, 

and are not in 

production

d. e. f. 

In production (autocalculated)g. (Q.59a+Q.59d+Q.59h+Q.59k) h. (Q.59b+Q.59e+Q.59i+Q.59l) i. (Q.59c+Q.59f+Q.59j+Q.59m)

Notes for ADDITIONAL DATA Please provide any relevant notes or comments for data provided 

in this section.