cdc.gov/coronavirus

ACIP COVID-19 Vaccines Work Group

Dr. Matthew F. Daley, Work Group Chair

November 2, 2021
Daily trends in number of COVID-19 cases in the 

United States, all ages 

CDC. https://covid.cdc.gov/covid-data-tracker/#trends_dailycases. Accessed October 29, 2021

January 23, 2020 – October 28, 2021

2

Reported Cases: 45,846,153
 1.9 million cases

 8,300 hospitalizations

 2,316 Multisystem Inflammatory Syndrome in Children (MIS-C) cases

 94 deaths

 Burden extends beyond case counts; school interrupted, lives disrupted

Burden of COVID-19 in children 5-11 years of age
 Reviewing data for pediatric COVID-19 vaccines

– SARS-CoV-2 seropositivity in children 

– Pediatric COVID-19 epidemiology

– ScenarioHub Modeling results of the impact of pediatric vaccination

– Results of Pfizer-BioNTech clinical trial in children 5-11 years old

– GRADEing of evidence

– Discussion of the Evidence to Recommendations Framework

COVID-19 Work Group activities – October 2021

4
Pediatric Formulation

• 10μg dose, IM

• The vaccine is administered as a 2-dose series, 3 weeks apart

Evidence:

• 5-11 year olds: 4,600 participants in a clinical trial (3,100 received vaccine, 1,538 

received placebo)

• ≥12 years: >247,000,000 doses of Pfizer-BioNTech (30ug formulation) in the U.S.2

• Vaccine fully licensed in people ≥16 years old in August 2021, based on longer-term 

follow-up data

FDA expands Emergency Use Authorization (EUA) of the Pfizer-BioNTech 

COVID-19 Vaccine to include children 5 through 11 years of age1

1. https://www.fda.gov/emergency-preparedness-and-response/coronavirus-disease-2019-covid-19/comirnaty-and-pfizer-biontech-covid-19-vaccine

2. https://covid.cdc.gov/covid-data-tracker/#vaccinations_vacc-total-admin-rate-total- Accesses November 1st, 2021
 Pfizer-BioNTech: BNT162b2 use in children aged 5-11 years Dr. Gurtman (Pfizer)

Break

 PUBLIC COMMENT

 SARS-CoV-2 Epidemiology in Children Dr. Jones (CDC)

 Myocarditis in adolescents and young adults Dr. Oster (CDC)

 Vaccine safety surveillance in children Dr. Shimabukuro (CDC)

 Implementation of COVID-19 vaccine pediatric program Dr. Chatham-Stevens (CDC)

Break

 Clinical considerations Dr. Woodworth (CDC)

 Evidence to Recommendations Framework Dr. Oliver (CDC)

VOTE

Agenda: Tuesday November 1, 2021
ACIP members

 Matthew Daley (chair)

 Beth Bell 

 Grace Lee

 Keipp Talbot

 Oliver Brooks

Ex-officio/government members

 FDA: Doran Fink, Rachel Zhang

 NIH: Chris Roberts

 IHS: Thomas Weiser, Uzo Chukwuma

 DOD: Bryan Schumacher

 CMS: Jeff Kelman

 BARDA: Christine Oshansky

 HHS: David Kim

CDC Leads

 Sara Oliver

 Kathleen Dooling

Work group members

7

Liaisons

 AAFP: Jonathan Temte

 AAP: Sean O’Leary

 ACOG: Denise Jamieson (primary), 

Laura Riley (alternate)

 ACP: Jason Goldman

 AGS: Ken Schmader

 AIM: Rob Shechter (primary), 

Jane Zucker (alternate)

 AMA: Sandra Fryhofer

 ANA: Kendra McMillan (primary), 

Ruth Francis (alternate)

 APhA: Michael Hogue

 ASTHO: Marcus Plescia

 CSTE: Susan Lett (primary), 

Christine Hahn (alternate)

 IDSA: Jeff Duchin (primary), 

Carol Baker (alternate)

Liaisons, cont’d

 NACCHO: Matt Zahn (primary), 

Jeff Duchin (alternate)

 NACI: Matthew Tunis 

 NFID: Bill Schaffner (primary), 

Marla Dalton (alternate)

 NMA: Patricia Whitley-Williams

 SHEA: Marci Drees

Consultants

 Ed Belongia 

 Kathy Kinlaw 

 Dayna Matthew 

 Kathleen Neuzil 

 Stanley Perlman 

 Peter Szilagyi

 Jose Romero

 Hank Bernstein
 Sarah Mbaeyi

 Mary Chamberland

 Amanda Cohn

 Jack Gersten

 Monica Godfrey

 Stephen Hadler

 Danielle Moulia

 Megan Wallace

 Jennifer Collins

 Sujan Reddy

CDC participants

8

 Jefferson Jones

 Edwin Shanley

 Rita Helfand

 Cynthia Jorgensen

 Megan Lindley

 Ruth Link-Gelles

 Jessica MacNeil

 Lauri Markowitz

 Jean Cox-Ganser

 Meredith McMorrow

 Melinda Wharton

 Kate Woodworth

 Yon Yu

 Kristin Nordland

 Kevin Chatham-Stevens

 Erin Tromble

 Dana Meaney-Delman

 Thomas Clark

 Sam Graitcer

 Lisa Grohskopf

 Rebecca Morgan

 Titilope Oduyebo

 Heather Scobie

 Edwin Shanley

 Tom Shimabukuro

 Natalie Thornburg

 Thomas Clark

 Doug Campos-Outcalt

 Jillian Doss-Walker

 Andrew Kroger
For more information, contact CDC

1-800-CDC-INFO (232-4636)

TTY: 1-888-232-6348 www.cdc.gov

The findings and conclusions in this report are those of the authors and do not necessarily represent the 

official position of the Centers for Disease Control and Prevention.

Thank you!