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PREVAIL* Cohort Study						Print
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										Prevail CohortMillions of children worldwide get sick from viruses such as norovirus, respiratory syncytial virus (RSV), influenza (flu), and rotavirus, and many die from diseases caused by these viruses every year. While there are vaccines available to prevent illnesses caused by flu and rotavirus, vaccines are currently in development for norovirus and RSV. In order to develop effective vaccines, it is important to understand how these viruses interact with a child’s immune system and how the mother’s immunity may help fight these infections in the United States.
Building on the Success of the PREVAIL Cohort
Cincinnati Children’s PREVAIL Cohort team led by Mary Allen Staat, MD, MPH, and Ardythe Morrow, PhD, MSc, has been awarded a $31 million grant from NIH to conduct a new flu study called Influenza IMPRINT Cohort, which will look at immune responses to flu in babies.
Viral disease experts at CDC are partnering with doctors at Cincinnati Children’s Hospital Medical Center for the PREVAIL cohort study. This is the first multi-year CDC study in the United States that looks at how a mother’s immune system may help protect her children from illnesses caused by these viruses.
PREVAIL is a three-year study involving women and their infants. Participation in the study is voluntary. Participants will regularly provide samples and answer questions from their last trimester of pregnancy until their child is 2 years old. The information gathered from this study will
greatly improve our understanding of how viral infections impact a child’s immune system during the first 2 years of life,
provide evidence on how repeat infections affect the immune system,
offer insight into how a mother’s immune system may be protecting her children from infection, and
give doctors and scientists a better understanding of immune system responses.Doctors and scientists can use this information for developing new vaccines and improving those we have to help protect children from getting sick and dying.
This study is funded through CDC’s New Vaccine Surveillance Network.
Resources
PREVAIL study flyer [1 page]
PREVAIL study brochure [2 pages]
Frequently asked questions about PREVAIL [2 pages]
2017 Recommended Immunizations for Children from Birth Through 6 Years Old [2 pages]
CDC’s Breastfeeding Guidelines & Recommendations
Southwest Ohio Breastfeeding Coalition
American Academy of Pediatrics Breastfeeding InitiativesIf you have any questions about participating in PREVAIL, contact Amy Hoffman (hoffmaa@ucmail.uc.edu) or Jessica James (james2ja@ucmail.uc.edu) at the University of Cincinnati College of Medicine at (513) 584-4019.
If you have general questions about the PREVAIL study, please contact Jeanne Kleiman (Jeanne.Kleiman@cchmc.org / (513) 803-9163) or Nancy Back (Nancy.Back@cchmc.org / (513) 636-2479) at Cincinnati Children’s Hospital Medical Center.
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PREVAIL Cohort Study Investigators
Principal Investigators
Dr. Ardythe L. Morrow, PhD — Site Principal Investigator, Cincinnati Children’s Hospital Medical Center
Dr. Daniel C. Payne, PhD, MSPH — CDC Principal Investigator — NCIRD, Division of Viral Diseases
Co-Investigators
Dr. Mary Allen Staat, MD, MPH, Cincinnati Children’s Hospital Medical Center
Dr. Emily DeFranco DO, MS, University of Cincinnati College of Medicine
Dr. Elizabeth Schlaudecker, MD, MPH, Cincinnati Children’s Hospital Medical Center
Jeanne Kleiman, BS, ALC, CLC, CCRP, Site Project Manager, Cincinnati Children’s Hospital Medical Center
Allison Cline, RN BSN, Doctoral Student-Epidemiology, Cincinnati Children’s Hospital Medical Center
Amy Hoffman, BA, Senior Clinical Research Coordinator, University of Cincinnati Medical Center
Jessica James, Clinical Research Coordinator, University of Cincinnati Medical Center
Dr. Umesh D. Parashar, MBBS, MPH — Division of Viral Diseases, CDC
Dr. Holly Biggs, MD, MPH — Division of Viral Diseases, CDC
Dr. Angela Campbell, MD, MPH — Influenza Division, CDC
Dr. Jan Vinje, PhD — Division of Viral Diseases, CDC
Dr. Rachel Burke, PhD — Division of Viral Diseases, CDC
Dr. Aron J. Hall, DVM, MSPH — Division of Viral Diseases, CDC
Dr. Natalie Thornburg, PhD — Division of Viral Diseases, CDC
Dr. Susan Gerber, MD, MPH — Division of Viral Diseases, CDC
Alexandra Piasecki, MPH — Division of Viral Diseases, CDC
Dr. Michael Bowen, MS, PhD — Division of Viral Diseases, CDC

Footnote
*PREVAIL stands for Pediatric Respiratory and Enteric Virus Acquisition and Immunogenesis Longitudinal cohort.Top of Page
							
					
							Last Reviewed:  September 9, 2022						Source: 	National Center for Immunization and Respiratory Diseases (NCIRD), Coronavirus and Other Respiratory Viruses Division
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