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Tuberculosis (TB)


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Reported Tuberculosis in the United States, 2020					minus icon
                Table of Contents
			National DataState & Local DataRisk FactorsDemographicsTB Treatment and Case OutcomesDrug-Resistant TBGenotype ClustersEstimates of Recent Transmission					Related Pages
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Genotype ClustersOn This Page
			HighlightsGenotype Cluster Alert LevelsData TablesHighlightsClusters of TB cases with matching genotypes are an indication of possible recent TB transmission.
In this report, a TB case is clustered if it had a matching genotype with one or more other cases in the same county or county-equivalent area during the 3-year period of 2018–2020.The number of reported TB cases that were genotyped declined from 6,966 in 2019 to 5,551 in 2020, a 20.3% reduction mirroring overall case count declines. However, similar to previous years, 97.5% of culture positive cases were associated with a genotype in 2020 (TB Genotyping Surveillance Coverage: United States 2004–2020).
During 2018–2020, 19.0% of TB cases were clustered.
The highest percentages of genotype-clustered cases continue to be observed among American Indian or Alaska Native persons (53.4%) and Native Hawaiian or Other Pacific Islander persons (51.4%) (Characteristics of TB Cases in GENType Clusters by Alert Levels: 2018–2020).
Hispanic or Latino persons (n=1,230) and non-Hispanic Black or African American persons (n=958) represented the highest number of clustered cases.The number of county-based clusters declined from 1,351 in last year’s report(cases reported nationally during 2017–2019) to 1,280 clusters for 2018–2020, a 5.3% reduction.Genotype Cluster Alert LevelsPercentage of Social Risk Factor Among Persons Aged ≥15 Years with TB, United States, 2020resize iconView LargerClosePercentage of Social Risk Factor Among Persons Aged ≥15 Years with TB, United States, 2020download iconDownload Image[PNG]
Genotype clusters are additionally characterized into an alert level of non-alert, medium alert, or high alert based on a log-likelihood ratio calculation. Alert levels represent the degree of spatial concentration of cases within the same county or county-equivalent area as compared with the concentration of the genotype in the nation.
For 2018–2020, 38.5% of clustered cases were included in clusters that were classified as either medium or high alert, which are reviewed for possible programmatic follow-up (Characteristics of TB Cases in GENType Clusters by Alert Levels: 2018–2020).Learn more in the Executive Commentary.Data Tables
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Genotype ClustersTB Genotyping Surveillance Coverage: United States, 2004–2020
TB Genotyping Surveillance Coverage: U.S.-Affiliated Areas, 2004–2020
*Mycobacterium bovis* by Origin of Birth: 2004–2020
Characteristics of TB Cases in GENType Clusters, by Alert Levels: 2018–2020
TB Clusters by Size: 2018–2020
Most Frequently Reported GENTypes: U.S., 2018–2020
Most Frequently Reported GENTypes: U.S.-Affiliated Areas, 2018–2020
TB Genotyping Surveillance Coverage: Reporting Areas, 2020Top of Page
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						Page last reviewed:  October 18, 2021					Content source: 	Division of Tuberculosis Elimination, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention homeTuberculosisBasic TB Factsplus iconHow TB SpreadsLatent TB Infection and TB DiseaseSigns & SymptomsTB Risk FactorsExposure to TBTB PreventionVaccinesTB & HIV CoinfectionTB and DiabetesTB TermsPersonal StoriesTesting & Diagnosisplus iconWho Should be TestedTesting for TB InfectionTesting in BCG-Vaccinated PersonsTB Screening and Testing of Health Care PersonnelTesting During PregnancyDiagnosing latent TB infection and TB diseaseTreatmentplus iconDeciding When to Treat Latent TB InfectionTreatment Regimens for Latent TB Infection (LTBI)Treatment for TB DiseaseAdverse EventsTB Treatment of Persons Living with HIVTB Treatment and PregnancyTB Treatment for ChildrenFrequently Asked QuestionsDrug-Resistant TBResearchplus iconTB Epidemiologic Studies Consortiumplus iconResearch ProjectsPublicationsTB Trials Consortiumplus iconStudy DescriptionsBackgroundBehavioral & Social Science ResearchHealth Care Settingsplus iconTB Infection Control in Health Care SettingsResources for TB Screening and Testing of Health Care Personnelplus iconFrequently Asked QuestionsTB in Specific Populationsplus iconHealth DisparitiesAsian PersonsBlack or African American PersonsHispanic or Latino PersonsChildrenPregnancyCorrectional FacilitiesPeople Experiencing HomelessnessInternational TravelersLaboratory Informationplus iconDrug Susceptibility TestingFalse-Positive Investigation ToolkitInterim Laboratory Biosafety Guidance for XDR  tuberculosis strainsModel Performance Evaluation Program (MPEP)Rapid Molecular Testing to Detect Drug-Resistant TB in the USplus iconExecutive SummaryIntroductionBackground on Tests for Molecular Detection of DRGeneral Considerations and Principles for a Molecular DR Testing ServicePossible Scenarios and Scope of Testing for a Molecular DR Testing ServiceResearch NeedsGeneral Recommendations of the Expert PanelCommunication Plan for the ReportRecommendationsReferencesPanel Members and CDC ParticipantsAppendix 1Appendix 2Appendix 3The Uses of Nucleic Acid Amplification Tests for the Diagnosis of TBplus iconGeneral ConsiderationsGeneral Recommendations of the Expert PanelRecommendations to ACET, CDC, DTBEData & Statisticsplus iconTB Incidence in the United StatesReported TB in the US, 2022 Surveillance Reportplus iconNational DataReporting Area DataRisk FactorsDemographicsTB Treatment and Case OutcomesDrug-Resistant TBMolecular SurveillanceTuberculosis in the United States, 2022 (Slide Set)Archived Surveillance Reports and Slide Sets2021 State and City ReportArchived State and City ReportsProfessional Resources & Toolsplus iconTools for Healthcare ProvidersResources for TB Programsplus iconStrengthening Civil Surgeons’ Capacity to Improve LTBI Surveillance and Outcomes Among Status AdjustersNotice of Funding Opportunity (NOFO)Program EvaluationTB Centers of ExcellenceTB Elimination AllianceTB Genotypingplus iconConventional TB GenotypingWhole Genome SequencingTB GIMSAnalytic ToolsLatent Tuberculosis Infection ResourcesPublications & Productsplus iconPatient and Public MaterialsFact SheetsGuidelinesplus iconControl & EliminationDrug-Resistant TBInfection Control & PreventionLaboratory & GenotypingTB & HIVTB in Specific PopulationsTesting & DiagnosisTreatmentVaccines & ImmunizationsArchived TB GuidelinesGuides & Toolkitsplus iconAggregate ReportsCDC TB Surveillance TrainingCore CurriculumEffective TB Interviewing for Contact InvestigationEthnographic GuidesFalse-Positive Investigation ToolkitForging Partnerships to Eliminate TuberculosisGuide to Application of GenotypingLTBI: A Guide for Primary Health Care ProvidersMantoux Tuberculin Skin Testing ProductsReport of Verified Case of Tuberculosis (RVCT)Self-Study ModulesTB Contact Investigation Interviewing Skills CourseTB eDOT ToolkitUnderstanding the TB Cohort Review ProcessNewslettersplus iconTB Notes, No. 4, 2023TB Notes, No. 3, 2023TB Notes. No. 2, 2023TB Notes. No. 1, 2023TB Notes, No. 4, 2022TB Notes, No. 3, 2022TB Notes, No. 2, 2022TB Notes, No. 1, 2022TB Notes, No. 4, 2021TB Notes, No. 3, 2021TB Notes, No. 2, 2021TB Notes, No. 1, 2021Pamphlets, Brochures, Bookletsplus iconQuestions and AnswersPatient Education SeriesTuberculosis - Get the FactsTuberculosis - The Connection between TB and HIV12-Dose Regimen for Latent TB Infection-Patient Education BrochurePostersplus iconMantoux Tuberculin Skin Test Wall ChartWorld TB DayThink TBStop TBTake on TBReports & Articlesplus iconDTBE Authored Journal ArticlesTuberculosis Laboratory Aggregate ReportsSlide Setsplus iconIntroduction to TuberculosisEpidemiology of Tuberculosis Among Non-U.S.​–Born Persons in the United States, 1993–2016Self-Study Modules on Tuberculosis, 1-5 Slide SetsThe Tuberculosis (TB) in Correctional Settingsplus iconFacilitator GuideIntroduction to TB GenotypingEpidemiology of Tuberculosis in Correctional Facilities, United States, 1993-2017Prevention and Control of Tuberculosis in Correctional and Detention FacilitiesGuidelines for Preventing the Transmission of M. TB in Health care SettingsInvestigation of Contacts of Persons with Infectious TBEpidemiology of Pediatric Tuberculosis in the United StatesTargeted Tuberculosis Testing and Treatment of Latent Tuberculosis InfectionElectronic Tools & ResourcesWeb-Based Courses & Webinarsplus iconTB 101 for Health Care WorkersContent SyndicationInfographicsplus iconSocial Media GraphicsCustomizable Take on TB Infographic with InstructionsEventsWorld TB Dayplus iconU.S. TB ChampionsHistoryFeaturesplus iconTB Risk FactorsTreating Latent TB Infection with Short-Course RegimensWorld Tuberculosis (TB) Day 2021World Tuberculosis (TB) Day 2020Linksplus iconState TB Control OfficesAbout Usplus iconMission Statement and Activitiesplus iconDTBE Strategic PlanNational TB Program ObjectivesOrganization ChartAdvisory Groupsplus iconFederal TB Task Force To receive email updates about this page, enter your email address: Email Address			What's this?				Submit


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