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TB contact, cluster, and outbreak investigations are frequently complicated by challenges associated with managing and analyzing large volumes of diverse data.
For example, it is not uncommon for location-based contact investigations to identify multiple potential exposure locations and hundreds of potential contacts. Manually organizing and comparing large amounts of location and date data to identify overlaps between persons at locations and prioritize contacts of concern can be an extremely tedious and error-prone task.
During investigations of large TB clusters or outbreaks, public health practitioners routinely attempt to characterize transmission networks by evaluating:
surveillance data, epidemiologic links, and other data from contact investigations,
chronology data related to the timing of symptom onset and infectious periods, and
genomic data used to estimate the relatedness of isolates collected from patients.Overviewmedia iconLow Resolution Video
Systematically and iteratively synthesizing and analyzing these disparate data as an investigation proceeds can be exceedingly time consuming and computationally difficult.
To help TB control program staff overcome these challenges, CDC has developed multiple tools for use in management and analysis of data collected during TB contact, cluster, and outbreak investigations. These tools and associated resources are described below.
View on YouTubeCLINTmedia iconLow Resolution Video
The **Cl**uster **IN**vestigation **T**ool (CLINT) helps users organize and summarize genotyping and surveillance data routinely collected as part of TB cluster investigations and uploaded to the TB Genotyping Information System (TB GIMS).
View on YouTubeLITTmedia iconLow Resolution Video
The **L**ogically **I**nferred **T**uberculosis **T**ransmission (LITT) algorithm automates the integration and analysis of surveillance data, epidemiologic link data, data on estimated infectious period dates, and whole genome sequencing data collected from pathogen isolates to characterize TB transmission networks.
**Resources**
Manuscriptexternal icon, user’s manual, training presentation, input file templates, training datasets, and R code available on GitHubexternal icon
Online user interface available through CDC’s OAMD portal (https://amdportal-sams.cdc.gov/portal/)
Access requests can be sent to TBGenotyping@cdc.govView on YouTubeLATTEmedia iconLow Resolution Video
The **L**ocation **A**nd **T**ime **T**o **E**pidemiology (LATTE) algorithm automates the comparison and visualization of date data collected during location-based contact investigations (dates of stays in locations, estimated dates of infectious periods) to identify and prioritize contacts of concern for follow-up.
**Resources**
User’s manual, training presentation, input file templates, training datasets, and R code available on GitHubexternal iconOnline user interface available through CDC’s OAMD portal (https://amdportal-sams.cdc.gov/portal/)
Access requests can be sent to TBGenotyping@cdc.govView on YouTubeMicrobeTracemedia iconLow Resolution Video
MicrobeTrace, a browser-based, standalone tool built by the CDC Molecular Epidemiology and Bioinformatics team in the HIV Laboratory Branch, helps integrate, visualize, and explore demographic, genomic and contact tracing data collected during investigations of outbreaks and transmission clusters.
**Resources**
User’s manual and other resources available on GitHubexternal icon
Training presentationexternal icon
Access MicrobeTrace
Questions can be sent to the MicrobeTrace Help Desk at microbetrace@cdc.govView on YouTube
							
					
						Page last reviewed:  July 29, 2021					Content source: 	Division of Tuberculosis Elimination, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention homeTuberculosisBasic TB Factsplus iconHow TB SpreadsLatent TB Infection and TB DiseaseSigns & SymptomsTB Risk FactorsExposure to TBTB PreventionVaccinesTB & HIV CoinfectionTB and DiabetesTB TermsPersonal StoriesTesting & Diagnosisplus iconWho Should be TestedTesting for TB InfectionTesting in BCG-Vaccinated PersonsTB Screening and Testing of Health Care PersonnelTesting During PregnancyDiagnosing latent TB infection and TB diseaseTreatmentplus iconDeciding When to Treat Latent TB InfectionTreatment Regimens for Latent TB Infection (LTBI)Treatment for TB DiseaseAdverse EventsTB Treatment of Persons Living with HIVTB Treatment and PregnancyTB Treatment for ChildrenFrequently Asked QuestionsDrug-Resistant TBResearchplus iconTB Epidemiologic Studies Consortiumplus iconResearch ProjectsPublicationsTB Trials Consortiumplus iconStudy DescriptionsBackgroundBehavioral & Social Science ResearchHealth Care Settingsplus iconTB Infection Control in Health Care SettingsResources for TB Screening and Testing of Health Care Personnelplus iconFrequently Asked QuestionsTB in Specific Populationsplus iconHealth DisparitiesAsian PersonsBlack or African American PersonsHispanic or Latino PersonsChildrenPregnancyCorrectional FacilitiesPeople Experiencing HomelessnessInternational TravelersLaboratory Informationplus iconDrug Susceptibility TestingFalse-Positive Investigation ToolkitInterim Laboratory Biosafety Guidance for XDR  tuberculosis strainsModel Performance Evaluation Program (MPEP)Rapid Molecular Testing to Detect Drug-Resistant TB in the USplus iconExecutive SummaryIntroductionBackground on Tests for Molecular Detection of DRGeneral Considerations and Principles for a Molecular DR Testing ServicePossible Scenarios and Scope of Testing for a Molecular DR Testing ServiceResearch NeedsGeneral Recommendations of the Expert PanelCommunication Plan for the ReportRecommendationsReferencesPanel Members and CDC ParticipantsAppendix 1Appendix 2Appendix 3The Uses of Nucleic Acid Amplification Tests for the Diagnosis of TBplus iconGeneral ConsiderationsGeneral Recommendations of the Expert PanelRecommendations to ACET, CDC, DTBEData & Statisticsplus iconTB Incidence in the United StatesReported TB in the US, 2022 Surveillance Reportplus iconNational DataReporting Area DataRisk FactorsDemographicsTB Treatment and Case OutcomesDrug-Resistant TBMolecular SurveillanceTuberculosis in the United States, 2022 (Slide Set)Archived Surveillance Reports and Slide Sets2021 State and City ReportArchived State and City ReportsProfessional Resources & Toolsplus iconTools for Healthcare ProvidersResources for TB Programsplus iconStrengthening Civil Surgeons’ Capacity to Improve LTBI Surveillance and Outcomes Among Status AdjustersNotice of Funding Opportunity (NOFO)Program EvaluationTB Centers of ExcellenceTB Elimination AllianceTB Genotypingplus iconConventional TB GenotypingWhole Genome SequencingTB GIMSAnalytic ToolsLatent Tuberculosis Infection ResourcesPublications & Productsplus iconPatient and Public MaterialsFact SheetsGuidelinesplus iconControl & EliminationDrug-Resistant TBInfection Control & PreventionLaboratory & GenotypingTB & HIVTB in Specific PopulationsTesting & DiagnosisTreatmentVaccines & ImmunizationsArchived TB GuidelinesGuides & Toolkitsplus iconAggregate ReportsCDC TB Surveillance TrainingCore CurriculumEffective TB Interviewing for Contact InvestigationEthnographic GuidesFalse-Positive Investigation ToolkitForging Partnerships to Eliminate TuberculosisGuide to Application of GenotypingLTBI: A Guide for Primary Health Care ProvidersMantoux Tuberculin Skin Testing ProductsReport of Verified Case of Tuberculosis (RVCT)Self-Study ModulesTB Contact Investigation Interviewing Skills CourseTB eDOT ToolkitUnderstanding the TB Cohort Review ProcessNewslettersplus iconTB Notes, No. 4, 2023TB Notes, No. 3, 2023TB Notes. No. 2, 2023TB Notes. No. 1, 2023TB Notes, No. 4, 2022TB Notes, No. 3, 2022TB Notes, No. 2, 2022TB Notes, No. 1, 2022TB Notes, No. 4, 2021TB Notes, No. 3, 2021TB Notes, No. 2, 2021TB Notes, No. 1, 2021Pamphlets, Brochures, Bookletsplus iconQuestions and AnswersPatient Education SeriesTuberculosis - Get the FactsTuberculosis - The Connection between TB and HIV12-Dose Regimen for Latent TB Infection-Patient Education BrochurePostersplus iconMantoux Tuberculin Skin Test Wall ChartWorld TB DayThink TBStop TBTake on TBReports & Articlesplus iconDTBE Authored Journal ArticlesTuberculosis Laboratory Aggregate ReportsSlide Setsplus iconIntroduction to TuberculosisEpidemiology of Tuberculosis Among Non-U.S.​–Born Persons in the United States, 1993–2016Self-Study Modules on Tuberculosis, 1-5 Slide SetsThe Tuberculosis (TB) in Correctional Settingsplus iconFacilitator GuideIntroduction to TB GenotypingEpidemiology of Tuberculosis in Correctional Facilities, United States, 1993-2017Prevention and Control of Tuberculosis in Correctional and Detention FacilitiesGuidelines for Preventing the Transmission of M. TB in Health care SettingsInvestigation of Contacts of Persons with Infectious TBEpidemiology of Pediatric Tuberculosis in the United StatesTargeted Tuberculosis Testing and Treatment of Latent Tuberculosis InfectionElectronic Tools & ResourcesWeb-Based Courses & Webinarsplus iconTB 101 for Health Care WorkersContent SyndicationInfographicsplus iconSocial Media GraphicsCustomizable Take on TB Infographic with InstructionsEventsWorld TB Dayplus iconU.S. TB ChampionsHistoryFeaturesplus iconTB Risk FactorsTreating Latent TB Infection with Short-Course RegimensWorld Tuberculosis (TB) Day 2021World Tuberculosis (TB) Day 2020Linksplus iconState TB Control OfficesAbout Usplus iconMission Statement and Activitiesplus iconDTBE Strategic PlanNational TB Program ObjectivesOrganization ChartAdvisory Groupsplus iconFederal TB Task Force To receive email updates about this page, enter your email address: Email Address			What's this?				Submit


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