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Sexually Transmitted Infections Treatment Guidelines, 2021


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CDC’s STI Treatment Guidelines Timeline: The Evolution of Sexual Healthcare										Related Pages
					resize iconView LargerCloseSTI Treatment Guidelines Timelinedownload iconDownload Image[PNG]1943 – Penicillin used for the first time to treat and cure syphilis.
1940s-1950s – Penicillin and other antibiotics became the standard treatment for sexually transmitted diseases (STDs).
1960s – Improved diagnostics for gonorrhea (GC), helped pave the way for heightened U.S. government focus on gonorrhea control.
1972, 1974, 1979 – *Recommended Treatment Schedules for Gonorrhea* published in CDC’s *Morbidity and Mortality Weekly Report* (*MMWR*).
1979 – First STD prevention training center model clinics established. Known today as the National Network of STD Prevention Training Centers, these centers are central to training healthcare providers nationwide.
1982 – First comprehensive, CDC *Treatment Guidelines for STDs* published in *MMWR*.
1986 – Gonococcal Isolate Surveillance Program (GISP) established to help inform STD Treatment Guidelines updates.
1989 – Due to increasing resistance, penicillin and tetracycline no longer recommended to treat GC. Ceftriaxone plus doxycycline was recommended for uncomplicated gonorrhea.
1989-1993 – The STD Treatment Guidelines evolved from a quick reference guide on treatment into a more comprehensive care resource providing patient-centered care.
1993 – Fluoroquinolones became one of the recommended options for GC treatment. Public awareness of human papilloma virus (HPV) grows, leading to expansion of coverage in STD Treatment Guidelines content.
1990s-early 2000s – STD Treatment Guidelines go digital with first website established – making all content freely available online.
2006 – STD Treatment Guidelines expansion to discuss management of asymptomatic persons at risk for STDs.
2007 – Fluoroquinolones no longer recommended for GC treatment – cephalosporins became backbone of GC treatment.
2010 – STD Treatment Guidelines Pocket Guide and high-resolution Wall Chart created.
2012 –Ceftriaxone only recommended antimicrobial to treat gonorrhea.
2013 – STD Treatment Guidelines App created – allowing more providers to access the Guidelines.
2015 – Last full edition of STD Treatment Guidelines released; included updates on alternative treatment regimens for gonorrhea, transgender healthcare management, the role of *Mycoplasma genitalium* in urethritis/cervicitis, and retesting to detect repeat chlamydia, gonorrhea, and trichomonas infections.
Today – CDC, with consultation from experts in the field, continues to update based on emerging evidence as appropriate the STI Treatment Guidelines to ensure healthcare providers have access to optimal management and treatment guidance.
							
					
						Page last reviewed:  August 2, 2021					Content source: 	Division of STD Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention homeSTI Treatment Guidelines, 2021
Provider Resourcesplus icon
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Screening Recommendations
Tables of Evidence
Table of Contents
Summary and Introduction
Methods
Clinical Prevention Guidanceplus icon
STI and HIV Infection Risk Assessment
Primary Prevention Methods
Partner Servicesplus icon
Expedited Partner Therapy (EPT)
Reporting and Confidentiality
Retesting After Treatment to Detect Repeat Infections
Detection of STIs in Special Populationsplus icon
Pregnant Women
Adolescents
Children
MSM
WSW and WSWM
Transgender and Gender Diverse Persons
Persons in Correctional Facilities
HIV Infection: Detection, Counseling, and Referral
Diseases Characterized by Genital, Anal, or Perianal Ulcersplus icon
Chancroid
Genital Herpes
Granuloma Inguinale (Donovanosis)
Lymphogranuloma Venereum (LGV)
Syphilisplus icon
Primary and Secondary Syphilis
Latent Syphilis
Tertiary Syphilis
Neurosyphilis, Ocular Syphilis, and Otosyphilis
Syphilis Among Persons with HIV Infection
Syphilis During Pregnancy
Congenital Syphilis
Managing Persons Who Have a History of Penicillin Allergy
Diseases Characterized by Urethritis and Cervicitis
Chlamydial Infections
Gonococcal Infectionsplus icon
Gonococcal Infections Among Adolescents and Adults
Gonococcal Infections Among Neonates
Gonococcal Infections Among Infants and Children
*Mycoplasma genitalium*
Vulvovaginal Itching, Burning, Irritation, Odor or Dischargeplus icon
Bacterial Vaginosis
Trichomoniasis
Vulvovaginal Candidiasis
Pelvic Inflammatory Disease (PID)
Epididymitis
Human Papillomavirus (HPV) Infectionplus icon
Anogenital Warts
HPV-Associated Cancers and Precancers
Viral Hepatitisplus icon
HAV
HBV
HCV
Proctitis, Proctocolitis, and Enteritis
Ectoparasitic Infections
Sexual Assault and Abuse and STIsplus icon
Adolescents and Adults
Sexual Assault or Abuse of Children
References
Terms and Abbreviations Used in This Report
Workgroup Members
Timeline of STI Treatment Guidelines STDs Home Page
 Treatment
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