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Sexually Transmitted Infections Treatment Guidelines, 2021


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Table 6 – STI Treatment Guidelines										Related Pages
					Recommended doses of licensed formulations of hepatitis B vaccines
Table 6
Age group (yrs)
Single-antigen vaccine
Combination vaccineRecombivax HB
Engerix-B
Heplisav-B*
Twinrix†Dose (*μ*g)§
Volume (mL)
Dose (*μ*g)§
Volume (mL)
Dose (*μ*g)§
Volume (mL)
Dose (*μ*g)§
Volume (mL)Infants (<1)
5
0.5
10
0.5
—¶
—¶
NA
NAChildren (1–10)
5
0.5
10
0.5
—¶
—¶
NA
NAAdolescents (11–15)
10**
1.0
NA
NA
—¶
—¶
NA
NAAdolescents (11–19)
5
0.5
10
0.5
—¶
—¶
NA
NAAdults (≥18)
—††
—††
—††
—††
20*
0.5
20†
1Adults (≥20)
10
1
20
1
20†
0.5
20†
1Hemodialysis patients and other immunocompromised persons (<20§§)
5
0.5
10
0.5
20
0.5
NA
NAHemodialysis patients and other immunocompromised persons (≥20)
40¶¶
1
40***
2.0
20
0.5
NA
NASource:Adapted from Schillie S, Vellozzi C, Reingold A, et al. Prevention of hepatitis B virus infection in the United States: recommendations of the Advisory Committee on Immunization Practices. MMWR Recomm Rep 2018;67(No. RR-1).
Abbreviation: NA = not applicable.
* Administered on a 2-dose schedule.
†Combined hepatitis A and B vaccines. This vaccine is recommended for persons aged ≥18 years who are at increased risk for both hepatitis B and hepatitis A virus infections.
§Recombinant hepatitis B surface antigen protein dose.
¶ Heplisav-B should not be used for vaccination of infants, children, or adolescents because the safety and effectiveness of Heplisav-B has not been established in persons aged <8 years and is not approved for use in these populations.
** Adult formulation administered on a 2-dose schedule.
†† Engerix-B and Recombivax HB are approved for use in persons of all ages.
§§Higher doses might be more immunogenic; however, no specific recommendations have been made.
¶¶Dialysis formulation administered on a 3-dose schedule at 0, 1, and 6 months.
*** Two 1.0-mL doses administered at one site, on a 4-dose schedule at 0, 1, 2, and 6 months.
							
					
						Page last reviewed:  July 22, 2021					Content source: 	Division of STD Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention homeSTI Treatment Guidelines, 2021
Provider Resourcesplus icon
Customizable Announcement
Screening Recommendations
Tables of Evidence
Table of Contents
Summary and Introduction
Methods
Clinical Prevention Guidanceplus icon
STI and HIV Infection Risk Assessment
Primary Prevention Methods
Partner Servicesplus icon
Expedited Partner Therapy (EPT)
Reporting and Confidentiality
Retesting After Treatment to Detect Repeat Infections
Detection of STIs in Special Populationsplus icon
Pregnant Women
Adolescents
Children
MSM
WSW and WSWM
Transgender and Gender Diverse Persons
Persons in Correctional Facilities
HIV Infection: Detection, Counseling, and Referral
Diseases Characterized by Genital, Anal, or Perianal Ulcersplus icon
Chancroid
Genital Herpes
Granuloma Inguinale (Donovanosis)
Lymphogranuloma Venereum (LGV)
Syphilisplus icon
Primary and Secondary Syphilis
Latent Syphilis
Tertiary Syphilis
Neurosyphilis, Ocular Syphilis, and Otosyphilis
Syphilis Among Persons with HIV Infection
Syphilis During Pregnancy
Congenital Syphilis
Managing Persons Who Have a History of Penicillin Allergy
Diseases Characterized by Urethritis and Cervicitis
Chlamydial Infections
Gonococcal Infectionsplus icon
Gonococcal Infections Among Adolescents and Adults
Gonococcal Infections Among Neonates
Gonococcal Infections Among Infants and Children
*Mycoplasma genitalium*
Vulvovaginal Itching, Burning, Irritation, Odor or Dischargeplus icon
Bacterial Vaginosis
Trichomoniasis
Vulvovaginal Candidiasis
Pelvic Inflammatory Disease (PID)
Epididymitis
Human Papillomavirus (HPV) Infectionplus icon
Anogenital Warts
HPV-Associated Cancers and Precancers
Viral Hepatitisplus icon
HAV
HBV
HCV
Proctitis, Proctocolitis, and Enteritis
Ectoparasitic Infections
Sexual Assault and Abuse and STIsplus icon
Adolescents and Adults
Sexual Assault or Abuse of Children
References
Terms and Abbreviations Used in This Report
Workgroup Members
Timeline of STI Treatment Guidelines


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