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Reported Tuberculosis in the United States, 2022						Print
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										Return to Main MenuDrug-Resistant TBOn This Page
			HighlightsData TablesDrug Resistant TBHighlightsResistance to anti-TB drugs is a concern in the United States and globally.
Resistance to isoniazid, one of the most common anti-TB drugs, can be a precursor to multidrug-resistant (MDR) TB disease, which is caused by an organism that is resistant to at least isoniazid and rifampin.
Pre-extensively drug-resistant TB (pre-XDR TB) disease is caused by an organism that is resistant to isoniazid, rifampin, and a fluoroquinolone OR by an organism that is resistant to isoniazid, rifampin, and a second-line injectable (i.e., amikacin, capreomycin, and kanamycin).
Extensively drug-resistant TB (XDR TB) disease is caused by an organism that is resistant to isoniazid, rifampin, a fluroquinolone, and a second-line injectable (i.e., amikacin, capreomycin, and kanamycin) OR by an organism that is resistant to isoniazid, rifampin, a fluoroquinolone, and bedaquiline or linezolid.Percentage of TB Cases,* by Initial Drug Regimen, United States, 2021 (N=7,174)View LargerClosePercentage of TB Cases,* by Initial Drug Regimen, United States, 2021 (N=7,174)Download Image[PNG]
During 2022, resistance to at least isoniazid at initial diagnosis was reported for 528 (8.4%) cases in the United States, including 90 (1.4%) MDR cases.
Among U.S.-born persons, 86 (5.7%) cases were INH-resistant TB, including 11 (0.7%) cases of MDR TB.
Among non-U.S.–born persons, 439 (9.3%) cases were INH-resistant TB, including 77 (1.6%) cases of MDR TB.Pre-XDR and XDR TB continue to be rare in the United States, with 16 cases of pre-XDR TB and five cases of XDR TB reported in 2022. Stringent guidelines for TB treatment in the United States, including diligent follow-up efforts by public health personnel, greatly reduce the risk of developing drug-resistant TB.
Learn more in the Executive Commentary.Data Tables
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Drug-Resistant TBTB by Drug Resistance: 1993–2022
TB by Drug Resistance Among U.S.-Born Persons: 1993–2022
TB by Drug Resistance Among Non-U.S.–Born Persons: 1993–2022Top of Page
							
					
							Last Reviewed:  November 15, 2023						Source: 	Division of Tuberculosis Elimination, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention
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No. 1, 2023TB Notes, No. 4, 2022TB Notes, No. 3, 2022TB Notes, No. 2, 2022TB Notes, No. 1, 2022TB Notes, No. 4, 2021TB Notes, No. 3, 2021TB Notes, No. 2, 2021TB Notes, No. 1, 2021Pamphlets, Brochures, Bookletsplus iconQuestions and AnswersPatient Education SeriesTuberculosis - Get the FactsTuberculosis - The Connection between TB and HIV12-Dose Regimen for Latent TB Infection-Patient Education BrochurePostersplus iconMantoux Tuberculin Skin Test Wall ChartWorld TB DayThink TBStop TBTake on TBReports & Articlesplus iconDTBE Authored Journal ArticlesTuberculosis Laboratory Aggregate ReportsSlide Setsplus iconIntroduction to TuberculosisEpidemiology of Tuberculosis Among Non-U.S.​–Born Persons in the United States, 1993–2016Self-Study Modules on Tuberculosis, 1-5 Slide SetsThe Tuberculosis (TB) in Correctional Settingsplus iconFacilitator GuideIntroduction to TB GenotypingEpidemiology of Tuberculosis in Correctional Facilities, United States, 1993-2017Prevention and Control of Tuberculosis in Correctional and Detention FacilitiesGuidelines for Preventing the Transmission of M. TB in Health care SettingsInvestigation of Contacts of Persons with Infectious TBEpidemiology of Pediatric Tuberculosis in the United StatesTargeted Tuberculosis Testing and Treatment of Latent Tuberculosis InfectionElectronic Tools & ResourcesWeb-Based Courses & Webinarsplus iconTB 101 for Health Care WorkersContent SyndicationInfographicsplus iconSocial Media GraphicsCustomizable Take on TB Infographic with InstructionsEventsWorld TB Dayplus iconU.S. TB ChampionsHistoryFeaturesplus iconTB Risk FactorsTreating Latent TB Infection with Short-Course RegimensWorld Tuberculosis (TB) Day 2021World Tuberculosis (TB) Day 2020Linksplus iconState TB Control OfficesAbout Usplus iconMission Statement and Activitiesplus iconDTBE Strategic PlanNational TB Program ObjectivesOrganization ChartAdvisory Groupsplus iconFederal TB Task Force To receive email updates about this page, enter your email address: Email Address			What's this?				Submit


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