Exhibit 4.1


 




	
  

  	
  This is to
  Certify that SPECIMEN is the owner of non-assessable shares of the above
  Corporation transferable only on the books of the Corporation by the holder
  thereof in person or by a duly authorized Attorney upon surrender of this
  Certificate properly endorsed. Witness, the seal of the Corporation and the
  signatures of its duly authorized officers. Dated Rogerio Vivaldi Coelho, MD,
  MBA, President Joe Reilly, Secretary

  






 















	
  

  	
  The following
  abbreviations, when used in the inscription on the face of this certificate,
  shall be constructed as though they were written out in full according to
  applicable laws or regulations: TEN COM — as tenants in common TEN ENT — as
  tenants by the entireties JT TEN — as joint tenants with right of
  survivorship and not as tenants in common Additional abbreviations may also
  be used though not in the above list. 
  UNIF GIFT MIN ACT Custodian (Cust) (Minor) under Uniform Gifts to
  Minors Act (State) for value received hereby sell, assign and transfer unto
  please insert social security or other identifying number of assignee (please
  print or typewrite name and address including postal zip code of assignee)
  shares represented by the within Certificate, and do hereby irrevocably
  constitute and appoint Attorney to transfer the said shares on the books of
  the within named corporation with full power of substitution in their
  premises. Dated In presence of NOTICE: THE SIGNATURE TO THIS ASSIGNMENT MUST
  CORRESPOND WITH THE NAME AS WRITTEN UPON THE FACE OF THE CERTIFICATE IN EVERY
  PARTICULAR WITHOUT ALTERATION OR ENLARGEMENT OR ANY CHANGE WHATEVER. THE
  SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES
  ACT OF 1933, AS AMENDED (THE “ACT”), OR UNDER THE SECURITIES LAWS OF
  APPLICABLE STATES, AND HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW
  TO, OR IN CONNECTION WITH, THE SALE OR DISTRIBUTION THEREOF, THESE SECURITIES
  ARE SUBJECT TO RESTRICTIONS ON TRANSFERABILITY AND RESALE AND MAY NOT BE
  TRANSFERRED OR RESOLD EXCEPT AS PERMITTED UNDER THE ACT AND APPLICABLE STATE
  SECURITIES  LAWS PURSUANT TO
  REGISTRATION OR EXEMPTION THEREFORM, OR AN OPINION OF COUNSEL IN A
  FORM SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED
  UNDER THE ACT. INVESTORS SHOULD BE AWARE THAT THEY MAY BE REQUIRED TO
  BEAR THE FINANCIAL RISKS OF THIS INVESTMENT FOR AN INDEFINITE OF TIME. THE
  SALE OR TRANSFER OF THE SECURITIES REPRESENTED BY THIS CERTIFICATE IS SUBJECT
  TO THE TERMS AND CONDITIONS OF A CERTAIN SECOND AMENDED AND RESTATED RIGHT OF
  FIRST REFUSAL AND CO-SALE AGREEMENT DATED AUGUST 29, 2007 (AS SUCH
  MAY BE AMENDED FROM TIME TO TIME) BY AND AMONG THE REGISTERED HOLDER (OR
  HIS PREDECESSOR IN INTEREST), THE COMPANY, CERTAIN INVESTORS OF THE COMPANY,
  AND THE OTHER PARTIES NAMED THEREIN. A COPY OF SUCH AGREEMENT IS ON FILE AT
  THE PRINCIPAL OFFICE OF THE COMPANY. THE SALE OR TRANSFER OF THE SECURITIES
  REPRESENTED BY THIS CERTIFICATE IS SUBJECT TO THE TERMS AND CONDITIONS OF A
  CERTAIN LOCKUP AGREEMENT BY AND AMONG THE REGISTERED HOLDER (OR HIS
  PREDECESSOR IN INTEREST), AND JEFFERIES LLC, AS LEAD UNDERWRITER FOR THE
  COMPANY IN ITS INITIAL PUBLIC OFFERING OF SHARES PF COMMON STOCK. A COPY OF
  SUCH AGREEMENT IS ON FILE AT THE PRINCIPAL OFFICE OF THE COMPANY.