September 2005

NIOSH Publication Number 2005-149 

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## Epichlorohydrin

Synonyms & Trade Names 1 - Chloro

- 2,3 - epoxypropane; 2 - Chloropropylene oxide; gamma

- Chloropropylene oxide
CAS No. 106

- 89

- 8 RTECS No. TX4900000(/nioshrtecs/TX4AC4A0.html) DOT ID & Guide 2023 131P (http://wwwapps.tc.gc.ca/saf sur/3/erg- gmu/erg/guidepage.aspx?guide=131&poly=1)

Formula C 3 H 5 OCl Conversion 1 ppm = 3.78 mg/m IDLH Ca [75 ppm] See: 106898 (/niosh/idlh/106898.html) Exposure Limits NIOSH REL : Ca See Appendix A (nengapdxa.html) OSHA PEL †: TWA 5 ppm (19 mg/m ) [skin] Measurement Methods NIOSH 1010 (/niosh/docs/2003- 154/pdfs/1010.pdf) OSHA 7 (http://www.osha.gov/dts/sltc/methods/organic/org00 1/org001.html) See: NMAM (/niosh/docs/2003-154/) or OSHA Methods (http://www.osha.gov/dts/sltc/methods/index.html) Physical Description Colorless liquid with a slightly irritating, chloroform

- like odor.
MW: 92.5 BP: 242°

F FRZ: - 54°F Sol: 7% VP: 13 mmHg IP: 10.60 eV

Sp.Gr: 1.18 Fl.P: 93°

F UEL: 21.0% LEL: 3.8% Class IC Flammable Liquid: Fl.P. at or above 73°F and below 100°F. Incompatibilities & Reactivities Strong oxidizers, strong acids, certain salts, caustics, zinc, alumin um, water [Note: May polymerize in presence of strong acids and bases, p articularly when hot.] Exposure Routes inhalation, skin absorption, ingestion, skin and/or eye contact 3

3 Page 1 of 2 CDC

- NIOSH Pocket Guide to Chemical Hazards

- Epichlorohydrin

7/29/2010 http://www.cdc.gov/niosh/npg/npgd0254.htmlPage last reviewed: February 3, 2009

Page last updated: February 3, 2009 Content source: National Institute for Occupational Safety and Health (NIOSH) Education and Informatio n Division Centers for Disease Control and Prevention 1600 C lifton Rd. Atlanta, GA 30333, USA 800-CDC-INFO (800-232-4636) TTY: (888) 232-6348, 24 Hours/Every Day - cdcinfo@cdc.gov Symptoms irritation eyes, skin with deep pain; nausea, vomiting; abdominal pain; resp d istress, cough; reproductive effects; [potential occupational carci nogen] Target Organs Eyes, skin, respiratory system, kidneys, liver, reproductive sy stem
Cancer Site [in animals: nasal cancer] Personal Protection/Sanitation (See protection codes (protect.html) ) Skin: Prevent skin contact Eyes: Prevent eye contact Wash skin: When contaminated Remove: When wet (flammable) Change: No recommendation Provide: Eyewash, Quick drench First Aid (See procedures (firstaid.html) ) Eye: Irrigate immediately Skin: Soap wash immediately Breathing: Respiratory support Swallow: Medical attention immediately

Respirator Recommendations NIOSH At concentrations above the NIOSH REL, or where there is no REL, at any detectable concentration: (APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and i s operated in a demand or other positive-pressure mode (APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure other positive-pressure mode in combination with an auxiliary self-contained positive- pressure breathing apparatus Escape: (APF = 50) Any air-purifying, full-facepiece respir ator (gas mask) with a chin-style, front- or back organic vapor and acid gas canister Any appropriate escape - type, self

- contained breathing apparatus Important additional information about respirator selection (pgintrod.html#mustread) See also: INTRODUCTION (/niosh/npg/pgintrod.html) See ICSC CARD: 0043 (/niosh/ipcsneng/neng0043.html) See MEDICAL TESTS: 0093 (/niosh/docs/2005-110/nmed0093.html) Page 2 of 2 CDC

- NIOSH Pocket Guide to Chemical Hazards

- Epichlorohydrin

7/29/2010 http://www.cdc.gov/niosh/npg/npgd0254.html