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Guide to the Application of Genotyping to Tuberculosis Prevention and Control										Related Pages
										**Appendix B: References and Useful Resources**
**Information on Packaging and Shipping Infectious Substances**
Cultures of *Mycobacterium tuberculosis* are considered “infectious substances” according to regulations of the U.S. Department of Transportation (DOT) and the International Air Transport Association (IATA). Shipping of infectious substances must follow regulations established by both organizations.
Useful information can be obtained at the following websites:
Government 49 CFR Parts 100-177 and Parts 178-199pdf iconexternal icon DOT regulations that pertain to the shipment of hazardous substances.CDC Biosafety General information about shipping regulations for infectious substances.Some of the salient regulations:
Personnel who prepare and ship specimens must receive specific training and pass a competence examination. Training must be repeated every 2 years (refresher and update).
Infectious substances must be packaged according to IATA Packing Instruction 602 and a shipper’s declaration for dangerous goods form must be prepared.
The genotyping laboratory must be notified by fax or e-mail when a package is shipped.
Packages must be sent by a carrier that has tracking capability so that lost packages can be located.Note: Dry ice must not be used unless other IATA precautions and regulations are followed.
							
					
						Page last reviewed:  September 27, 2016					Content source: 	Division of Tuberculosis Elimination, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention homeGuide to the Application of Genotyping to Tuberculosis Prevention and Control
Acknowledgments
Introduction to Tuberculosis Genotypingplus icon
Introduction to this Guide
Overview of Tuberculosis Genotyping
Overview of the CDC Tuberculosis Genotyping Program
TB Program Eligibility and Application Procedures
Tuberculosis Genotyping Case Studiesplus icon
Investigation of a Genotyping Cluster in a Low-Incidence State
Apparent Genotyping Cluster among Recent Immigrants from the Philippines
False-Positive Culture Investigation
Algorithm to Detect False-Positive Cultures
A Misdiagnosis that was Identified with Genotyping
Genotyping Used to Improve Contact and Cluster Investigations
Identification of Nontraditional Transmission Settings
Investigation of a Multistate Tuberculosis Outbreak
Homeless Shelter Outbreak Investigation
Using Genotyping to Evaluate the Impact of a Screening Program
CDC Tuberculosis Genotyping Laboratory Proceduresplus icon
Science behind Tuberculosis Genotyping
Description of Genotyping Methods
Submission of Isolates
Genotyping Results, Designation of Clusters, and Reporting
Suspected False-Positive Cultures
IS*6110*-based RFLP Analysis
Combining Genotyping and Epidemiologic Data to Improve Our Understanding of TB Transmissionplus icon
Definitions
Reading the Genotyping Laboratory Report
Comparing Genotyping and Epidemiologic Results from Two TB Patients
Comparing Genotyping and Epidemiologic Results from Three or More TB Patients
Clustering as a Surrogate Measure of Recent Transmission
Developing a Tuberculosis Genotyping Programplus icon
Developing a Written Plan
Initial Decisions
Establishing Procedures for:plus icon
Submitting Isolates
Receiving and Acting on Genotyping Results
Requesting RFLP Analysis
Submitting Additional Isolates from the Same Patient
Comparing Genotyping Results between Jurisdictions
False-Positive Cultures
Database Management and Quality Control
Special Issues
Applying Genotyping Results to Tuberculosis Control Practicesplus icon
Evaluating Matching Genotypes
Evaluating Nonmatching Genotypes
Suspected False-Positive Culture Investigations
Expanded Contact Investigations
Outbreak Investigations
Cluster Investigations
Monitoring Trends
Appendicesplus icon
Appendix A: Glossary and Abbreviations
Appendix B: References and Useful Resourcesplus icon
References Cited in the Guide
NTGSN Special Issue References
Information on Packaging and Shipping Infectious Substances
Core Steps of an Outbreak Investigation
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