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                                                                 Exhibit 10.22

                    FIRST AMENDED EMPLOYMENT, CONFIDENTIALITY
                          AND NON-COMPETITION AGREEMENT

       This First Amended Employment, Confidentiality and Non-Competition
Agreement (hereafter referred to as this "Agreement") is made by and between
CombinatoRx, Incorporated, a Delaware corporation having a usual place of
business at 650 Albany Street, Boston, Massachusetts 02118, (the "Company") and
Alexis Borisy of 117 Gray Street, Arlington, Massachusetts 02476 (the
"Employee") as of the 1st day of July, 2004 (the "Effective Date"), amending in
part and restating that certain Employment, Confidentiality and Non-Competition
Agreement between the parties dated as of the 1st day of May, 2000 (the
"Original Agreement").

       In consideration of the mutual promises, terms and conditions contained
in this Agreement, the parties agree as follows:

       1.     EMPLOYMENT. The Company agrees to continue the employment of the
Employee, and the Employee agrees to continue in the service of the Company,
subject to the terms and conditions contained in this Agreement.

       2.     TERM. The Employee's employment hereunder shall be for a term
commencing on the effective date hereof and continuing until terminated pursuant
to Section 4, below. The term of the Employee's employment hereunder is
hereafter referred to as "the term of this Agreement" or "the term hereof."

       3.     CAPACITY AND PERFORMANCE.

              (a)    During the term hereof, the Employee shall serve the
Company as its President and CEO. In addition, throughout the term of this
Agreement, the Company shall cause the Employee to be elected and re-elected as
a member of the Board of Directors of the Company (the "Board") and the Employee
shall so serve without additional compensation. Also without further
compensation, the Employee shall serve as a director and/or officer of one or
more of the Company's Affiliates if so elected or appointed from time to time.

              (b)    During the term hereof, the Employee shall be employed by
the Company on a full-time basis and shall have the authorities, and shall
perform the duties and responsibilities, of his position as President and CEO
and such other duties and responsibilities, reasonably consistent with his
position, as may be designated from time to time by the Board.

              (c)    During the term hereof, the Employee shall devote his full
business time and his best efforts, business judgment, skill and knowledge
exclusively to the advancement of the business and interests of the Company and
its Affiliates and to the discharge of his duties and responsibilities
hereunder. The Employee may serve on the board of directors or similar bodies of
corporations or other entities approved by the Board.

       4.     COMPENSATION AND BENEFITS. As compensation for all services
performed by the Employee under and during the term hereof and subject to
performance of the Employee's duties

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and of the obligations of the Employee to the Company and its Affiliates,
pursuant to this Agreement or otherwise:

              (a)    BASE SALARY. During the term hereof, the Company shall pay
the Employee a base salary at the rate of not less than Two Hundred and Sixty
Thousand Dollars ($260,000) per annum, payable in accordance with the regular
payroll practices of the Company for its executives and subject to increase (but
not decrease) from time to time by the Board, in its discretion. Such base
salary, as from time to time increased, is hereafter referred to as the "Base
Salary."

              (b)    PERFORMANCE BONUSES. The Employee shall be eligible to earn
a bonus annually during employment hereunder. Bonuses will be earned on the
basis of the Company's fiscal year. The amount of any bonus awarded to the
Employee shall be based on his performance and that of the Company against
reasonably attainable goals determined annually by the Board after consultation
with the Employee. The Employee's target bonus is initially thirty percent (30%)
of the Base Salary.

              (c)    STOCK OPTION AWARDS. The Board may, on an annual basis, in
its discretion, grant the Employee stock options based on his performance and
that of the Company against reasonably attainable goals. Such grants will be
made under the 2000 Stock Option Plan (the "Option Plan") and, except as
otherwise expressly provided herein, the awards will be governed by the terms of
the Option Plan.

              (d)    BENEFITS. During the term hereof, the Employee shall be
entitled to participate in any and all employee benefit plans from time to time
in effect for executives of the Company generally, except to the extent any such
plans are in a category of benefit otherwise provided to the Employee hereunder
(E.G., severance pay). Such participation shall be subject to the terms of the
applicable plan documents and Company policies generally applicable to its
executives.

              (e)    VACATIONS. During the term hereof, the Employee shall be
entitled to four (4) weeks of vacation per year, to be taken at such times and
intervals as shall be determined by the Employee, subject to the reasonable
business needs of the Company. Vacation shall otherwise be governed by the
policies of the Company, as in effect from time to time.

              (f)    BUSINESS EXPENSES. The Company shall pay or reimburse the
Employee for all reasonable business expenses incurred or paid by the Employee
in the performance of his duties and responsibilities hereunder, subject to such
reasonable substantiation and documentation as may be specified by the Company
from time to time.

       5.     TERMINATION OF EMPLOYMENT AND SEVERANCE BENEFITS. The Employee's
employment hereunder shall terminate under the following circumstances:

              (a)    DEATH. In the event of the Employee's death during the term
hereof, the Employee's employment hereunder shall immediately and automatically
terminate. In such event, the Company shall pay to the Employee's designated
beneficiary or, if no beneficiary has

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been designated by the Employee, to his estate, (i) the Base Salary earned but
not paid through the date of termination, (ii) pay for any vacation earned but
not used through the date of termination and (iii) any business expenses
incurred by the Employee but un-reimbursed on the date of termination, provided
that such expenses and required substantiation and documentation are submitted
within ninety (90) days of termination and that such expenses are reimbursable
under Company policy (all of the foregoing, "Final Compensation"). The Company
also shall pay to the Employee's designated beneficiary or, if none, his estate,
any bonus compensation earned but unpaid for the prior fiscal year. The Company
shall have no further obligation to the Employee hereunder.

              (b)    DISABILITY.

                     (i)    The Company may terminate the Employee's employment
       hereunder, upon notice to the Employee, in the event that the Employee
       becomes disabled through any illness, injury, accident or condition of
       either a physical or psychological nature and, as a result, is unable to
       perform substantially all of his duties and responsibilities hereunder,
       with or without reasonable accommodation, for one hundred and twenty
       (120) days during any period of three hundred and sixty-five (365)
       consecutive calendar days. In the event of such termination, the Company
       shall have no further obligation to the Employee, other than for payment
       of Final Compensation and any bonus compensation earned but unpaid for
       the prior fiscal year.

                     (ii)   The Board may designate another employee to act in
       the Employee's place during any period of the Employee's disability.
       Notwithstanding any such designation, the Employee shall continue to
       receive the Base Salary in accordance with Section 4(a) and benefits in
       accordance with Section 4(d), to the extent permitted by the then-current
       terms of the applicable benefit plans, until the Employee becomes
       eligible for disability income benefits under the Company's disability
       income plan or until the termination of his employment, whichever shall
       first occur. While receiving disability income payments under the
       Company's disability income plan, the Employee shall not be entitled to
       receive any Base Salary under Section 4(a) hereof, but shall continue to
       participate in Company benefit plans in accordance with Section 4(d) and
       the terms of such plans until the termination of his employment.

                     (iii)  If any question shall arise as to whether during any
       period the Employee is disabled through any illness, injury, accident or
       condition of either a physical or psychological nature so as to be unable
       to perform substantially all of his duties and responsibilities
       hereunder, the Employee may, and at the request of the Company shall,
       submit to a medical examination by a physician selected by mutual
       agreement of the Company and the Employee to determine whether the
       Employee is so disabled and such determination shall for the purposes of
       this Agreement be conclusive of the issue. If such question shall arise
       and the Employee shall fail to submit to such medical examination, the
       Company's determination of the issue shall be binding on the Employee.

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              (c)    BY THE COMPANY FOR CAUSE. The Company may terminate the
Employee's employment hereunder, upon notice, for Cause, meaning that there has
been a reasonable, good faith determination by the Board that one or more of the
following events has occurred, which determination is made after notice to the
Employee specifying in reasonable detail the nature of the Cause and a
reasonable opportunity for the Employee to be heard by the Board. The following
shall constitute Cause for termination:

                     (i)    The Employee's conviction of a felony;

                     (ii)   The Employee's willful failure to perform (other
       than by reason of disability), or gross negligence in the performance of,
       his duties and responsibilities as set forth in Section 3 hereof, which
       failure or negligence continues or remains uncured after thirty (30)
       days' notice to the Employee setting forth in reasonable detail the
       nature of such failure or negligence;

                     (iii)  Material breach by the Employee of any provision of
       this Agreement, which breach continues or remains uncured after thirty
       (30) days' notice to the Employee setting forth in reasonable detail the
       nature of such breach; or

                     (iv)   Material fraudulent conduct by the Employee with
       respect to the Company.

In the event of termination for Cause, the Company shall have no further
obligation to the Employee, other than for Final Compensation.

       (d)    BY THE COMPANY OTHER THAN FOR CAUSE. The Company may terminate the
Employee's employment hereunder other than for Cause at any time upon sixty (60)
days' notice to the Employee or Base Salary in lieu thereof. In the event of
such termination, in addition to Final Compensation and any bonus compensation
earned but unpaid for the prior fiscal year, the Company (i) shall provide the
Employee six (6) months of severance pay, at the rate of the Base Salary in
effect immediately prior to the termination, payable in a single lump sum within
ten (10) business days following termination of employment; (ii) shall pay the
premium cost of the Employee's participation in the Company's group medical and
dental plans for a period of six (6) months following the date of termination,
provided that the Employee is entitled to continue such participation under
applicable law and plan terms; and (iii) shall cause to become vested
twenty-five percent (25%) of the options granted pursuant to Section 4(c) hereof
or otherwise which remain unvested on the date of termination for each year of
the Employee's employment with the Company, which vesting shall be effective on
the date of termination, and the Employee shall have not less than ninety (90)
days following the date of termination to exercise all or any portion of such
options.

              (e)    BY THE EMPLOYEE FOR GOOD REASON. The Employee may terminate
his employment hereunder for Good Reason upon notice to the Company setting
forth in reasonable detail the nature of such Good Reason. The following shall
constitute Good Reason for termination by the Employee: (i) a material breach by
the Company of any of the material provisions of this Agreement, including
without limitation a reduction in the Employee's Base

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Salary or in the Employee's position, duties, responsibilities or authority; or
(ii) a relocation of the Employee's place of employment to a point beyond a
35-mile radius of the Company's current office. In the event of termination in
accordance with this Section 5(e), the Employee shall be entitled to the same
pay, benefit premium contributions and accelerated vesting of stock options and
option exercise period that he would have been entitled to receive had the
Employee's employment been terminated by the Company other than for Cause
pursuant to Section 5(d) above.

              (f)    BY THE EMPLOYEE OTHER THAN FOR GOOD REASON. The Employee
may terminate his employment hereunder at any time upon sixty (60) days' notice
to the Company. In the event of termination by the Employee pursuant to this
Section 5(f), the Board may elect to waive the period of notice, or any portion
thereof, and, if the Board so elects, the Company will pay the Employee his Base
Salary for the notice period (or for any remaining portion of the period). The
Company shall have no further obligation to the Employee, other than for any
Final Compensation and any bonus compensation earned but unpaid for the prior
fiscal year, due to him.

              (g)    UPON A CHANGE OF CONTROL.

                     (i)    If a Change of Control (as defined below) occurs
and, within two (2) years following such Change of Control, the Company
terminates the Employee's employment other than for Cause, or the Employee
terminates his employment for Good Reason, the Company (A) shall pay the
Employee, as severance pay, an amount equal to twenty-four (24) months' Base
Salary at the rate in effect on the date of termination of the Employee's
employment, payable in a single lump sum within five (5) business days following
the date of termination; (B) shall pay the premium cost of the Employee's
participation in the Company's group medical and dental plans for a period of
twenty-four (24) months following the date of termination, provided that the
Employee is entitled to continue such participation under applicable law and
plan terms; and (C) shall cause to become vested on the date of termination 100%
of the options granted pursuant to Section 4(c) hereof or otherwise which remain
unvested on that date and the Employee shall be entitled to not less than ninety
(90) days following the date of termination to exercise all or any portion of
such options.

                     (ii)   Notwithstanding the foregoing, in the event of a
Change of Control prior to an IPO in which the aggregate value of the sale
proceeds (including any retained shares) received by the venture capital
investors is less than one hundred and ten percent (110%) of the amount of their
investment, the severance pay under (g)(i)(A) directly above shall be reduced to
an amount equal to twelve (12) months' Base Salary and the Company's payment of
premium costs under (g)(i)(B) above shall not exceed twelve (12) months.

                     (iii)  In the event that it is determined that any payment
or benefit provided by the Company to the Employee or for his benefit, either
under this Agreement or otherwise, will be subject to the excise tax imposed by
section 4999 of the Internal Revenue Code or any successor provision ("section
4999"), the Company shall, prior to the date on which any amount of the excise
tax must be paid or withheld, make an additional lump sum payment (the "gross up
payment") to the Employee. The gross up payment will be sufficient, after giving

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effect to all federal, state and other taxes and charges (including interest and
penalties, if any) with respect to the gross up payment, to make the Employee
whole for all taxes (including withholding taxes) and any associated interest
and penalties, imposed under or as a result of section 4999. Determinations
under this Section 5(g)(iii) will be made by the Company's independent auditors
unless the Employee has reasonable objections to the use of that firm, in which
case the determinations will be made by a comparable firm chosen by the Employee
after consultation with the Company (the firm making the determinations being
referred to as the "Firm"). The determinations of the Firm will be binding upon
the Company and the Employee except as the determinations are established in
resolution (including without limitation by settlement) of a controversy with
the Internal Revenue Service to have been incorrect. All fees and expenses of
the Firm will be paid by the Company. If the Internal Revenue Service asserts a
claim that, if successful, would require the Company to make a gross-up payment
or an additional gross-up payment, the Company and the Employee will cooperate
fully in resolving the controversy with the Internal Revenue Service. The
Company will make or advance such gross-up payments as are necessary to prevent
the Employee from having to bear the cost of payments made to the Internal
Revenue Service in the course of, or as a result of, the controversy. The Firm
will determine the amount of such gross-up payments or advances and will
determine after resolution of the controversy whether any advances must be
returned by the Employee to the Company. The Company will bear all expenses of
the controversy and will gross the Employee up for any additional taxes that may
be imposed upon the Employee as a result of its payment of such expenses.

       6.     EFFECT OF TERMINATION. The provisions of this Section 6 shall
apply to any termination pursuant to Section 5 or otherwise.

              (a)    Performance by the Company in accordance with the
applicable provision of Section 5 shall constitute the entire obligation of the
Company to the Employee hereunder.

              (b)    Except for medical and dental plan coverage continued
pursuant to Section 5(d), 5(e) or 5(g) hereof, benefits shall terminate pursuant
to the terms of the applicable benefit plans based on the date of termination of
the Employee's employment without regard to any continuation of Base Salary or
other payment to the Employee following such date of termination.

              (c)    Provisions of this Agreement shall survive any termination
if so provided herein or if necessary or desirable to accomplish the purposes of
other surviving provisions, including without limitation the obligations of the
Employee under Sections 7, 8 and 9 hereof.

       7.     CONFIDENTIAL INFORMATION.

              (a)    The Employee acknowledges that the Company and its
Affiliates continually develop Confidential Information, that the Employee may
develop Confidential Information for the Company or its Affiliates and that the
Employee may learn of Confidential Information during the course of employment.
The Employee shall comply with the policies and procedures of the Company and
its Affiliates for protecting Confidential Information and shall not disclose to
any Person or use, other than as required by applicable law or for the proper

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performance of his duties and responsibilities to the Company and its
Affiliates, any Confidential Information obtained by the Employee incident to
his employment or other association with the Company or any of its Affiliates.
The Employee understands that this restriction shall continue to apply after his
employment terminates, regardless of the reason for such termination.

              (b)    All documents, records, tapes and other media of every kind
and description relating to the business, present or otherwise, of the Company
or any of its Affiliates and any copies, in whole or in part, thereof (the
"Documents"), whether or not prepared by the Employee, shall be the sole and
exclusive property of the Company and its Affiliates. The Employee shall
safeguard all Documents and shall surrender to the Company at the time his
employment terminates, or at such earlier time or times as the Board or its
designee may specify, all Documents then in the Employee's possession or
control.

       8.     ASSIGNMENT OF RIGHTS TO INTELLECTUAL PROPERTY. The Employee shall
maintain accurate and complete contemporaneous records of, and shall immediately
and fully disclose and deliver to the Company, all Intellectual Property, as
defined below. The Employee hereby assigns and agrees to assign to the Company
(or as otherwise directed by the Company) the Employee's full right, title and
interest in and to all Intellectual Property. The Employee agrees to execute any
and all applications for domestic and foreign patents, copyrights or other
proprietary rights and to do such other acts (including without limitation the
execution and delivery of instruments of further assurance or confirmation)
requested by the Company to assign the Intellectual Property to the Company and
to permit the Company to enforce any patents, copyrights or other proprietary
rights to the Intellectual Property. All copyrightable works that the Employee
creates shall be considered "work made for hire". If the Company is unable
because of the Employee's mental or physical incapacity or for any other reason
to secure the Employee's signature for any of the assignments or other
reasonably requested documents pertaining to the Intellectual Property, the
Employee hereby irrevocably designate and appoint the Company and its duly
authorized officers and agents as the Employee's agent and attorney in fact, to
act for and in his behalf and stead to execute and file said documents and to do
all other lawfully permitted acts to further the perfection, defense, and
enjoyment of the Company's rights relating to the Intellectual Property with the
same legal force and effect as if executed by the Employee. The Employee
stipulates and agrees that such appointment is a right coupled with an interest
and will survive his incapacity or unavailability at any future time.

       9.     RESTRICTED ACTIVITIES. The Employee agrees that some restrictions
on his activities during and after his employment are necessary to protect the
goodwill, Confidential Information and other legitimate interests of the
Company:

              (a)    While the Employee is employed by the Company and for a
period of twenty-four (24) months after his employment terminates (in the
aggregate, the "Non-Competition Period"), the Employee shall not, directly or
indirectly, whether as owner, partner, investor, consultant, agent, employee,
co-venturer or otherwise, compete with the Company's Business anywhere in the
world. The foregoing, however, shall not prevent or restrict the Employee from
owning, directly or indirectly, not more than five percent (5%) of the voting
securities of any publicly traded company for the sole purpose of a passive
investment. For the purposes of this Section 9, the Company's Business means
researching and developing a

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discovery platform that identifies novel, non-obvious combinations of active
molecules that will then become patent-protected therapeutics, utilizing an
automated, high-throughput process to search the combinatorial space using
disease-specific assays.

              (b)    The Employee further agrees that, during the
Non-Competition Period, other than on behalf of the Company during his
employment hereunder or through responses to general advertisements and
headhunters which, in either case, are not specifically targeted to Company
employees, the Employee will not hire or attempt to hire any employee of the
Company, assist in such hiring by any Person, encourage any such employee to
terminate his or her relationship with the Company or solicit or encourage any
Person to hire any such employee; solicit or encourage any independent
contractor providing services to the Company to terminate or diminish its
relationship with the Company or solicit or encourage any Person to hire or
engage any such independent contractor; or solicit or encourage any customer,
supplier or vendor of the Company to terminate or diminish its relationship with
it, or, in the case of a customer, to conduct with any Person any business or
activity which such customer conducts or could conduct with the Company or any
of its Affiliates; or solicit or encourage any of the foregoing to terminate or
breach any agreement, written or oral, with the Company or any of its
Affiliates.

       10.    ENFORCEMENT OF COVENANTS. The Employee acknowledges that he has
carefully read and considered all the terms and conditions of this Agreement,
including the restraints imposed upon him pursuant to Sections 7, 8 and 9
hereof. The Employee agrees that those restraints are necessary for the
reasonable and proper protection of the Company and that each and every one of
the restraints is reasonable in respect to subject matter, length of time and
geographic area. The Employee further acknowledges that, were he to breach any
of the covenants contained in Sections 7, 8 or 9 hereof, the damage to the
Company would be irreparable. The Employee therefore agrees that the Company, in
addition to any other remedies available to it, shall be entitled to preliminary
and permanent injunctive relief against any breach or threatened breach by the
Employee of any of said covenants. The parties further agree that, in the event
that any provision of Section 7, 8 or 9 hereof shall be determined by any court
of competent jurisdiction to be unenforceable by reason of its being extended
over too great a time, too large a geographic area or too great a range of
activities, such provision shall be deemed to be modified to permit its
enforcement to the maximum extent permitted by law.

       11.    CONFLICTING AGREEMENTS. The Employee hereby represents and
warrants that the execution of this Agreement and the performance of his
obligations hereunder will not breach or be in conflict with any other agreement
to which the Employee is a party or is bound and that the Employee is not now
subject to any covenants against competition or similar covenants or any court
order or other legal obligation that would affect the performance of his
obligations hereunder. The Employee will not disclose to or use on behalf of the
Company any proprietary information of a third party without such party's
consent.

       12.    DEFINITIONS. Words or phrases which are initially capitalized or
are within quotation marks shall have the meanings provided in this Section and
as provided elsewhere herein. For purposes of this Agreement, the following
definitions apply:

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              (a)    "Affiliates" means all persons and entities directly or
indirectly controlling, controlled by or under common control with the Company,
where control may be by either management authority or equity interest.

              (b)    "Change of Control" means the occurrence hereafter of (i) a
sale, merger or consolidation after which securities possessing more than fifty
(50%) percent of the total combined voting power of the Company's outstanding
securities have been transferred to or acquired by a Person or Persons different
from the Persons who held such percentage of the total combined voting power
immediately prior to such transaction; (ii) the sale, transfer or other
disposition of all or substantially all of the Company's assets to one or more
Persons (other than a wholly owned subsidiary of the Company or a parent company
whose stock ownership after the transaction is the same as the Company's
ownership before the transaction), or (iii) an acquisition, merger or similar
transaction or a divestiture of a substantial portion of the Company's business
after which the Employee's role is not substantially the same as such role prior
to the transaction.

              (c)    "Confidential Information" means any and all information of
the Company and its Affiliates that is not generally known by others with whom
they compete or do business, or with whom any of them plans to compete or do
business and any and all information, publicly known in whole or in part or not,
which, if disclosed by the Company or its Affiliates would assist in competition
against them. Confidential Information includes without limitation such
information relating to (i) the development, research, testing, manufacturing,
marketing and financial activities of the Company and its Affiliates, (ii) their
products and services, (iii) the costs, sources of supply, financial performance
and strategic plans of the Company and its Affiliates, (iv) the identity and
special needs of the customers of the Company and its Affiliates and (v) the
people and organizations with whom the Company and its Affiliates have business
relationships and those relationships. Confidential Information also includes
any information that the Company or any of its Affiliates have received, or may
receive hereafter, belonging to customers or others with any understanding,
express or implied, that the information would not be disclosed. Confidential
Information does not include information that enters the public domain, other
than through a breach by the Employee or another Person of an obligation of
confidentiality to the Company or any of its Affiliates.

              (d)    "Intellectual Property" means inventions, discoveries,
developments, methods, processes, compositions, works, concepts and ideas
(whether or not patentable or copyrightable or constituting trade secrets)
conceived, made, created, developed or reduced to practice by the Employee
(whether alone or with others, whether or not during normal business hours or on
or off Company premises) during the Employee's employment that relate to the
Company's business or that make use of Confidential Information or any of the
equipment or facilities of the Company.

              (e)    "Person" means an individual, a corporation, a limited
liability company, an association, a partnership, an estate, a trust and any
other entity or organization, other than the Company or any of its Affiliates.

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       13.    WITHHOLDING. All payments made by the Company under this Agreement
shall be reduced by any tax or other amounts required to be withheld by the
Company under applicable law.

       14.    ASSIGNMENT. Neither the Company nor the Employee may make any
assignment of this Agreement or any interest herein, by operation of law or
otherwise, without the prior written consent of the other; provided, however,
that the Company may assign its rights and obligations under this Agreement
without the consent of the Employee in the event that the Company shall
hereafter affect a reorganization, consolidate with, or merge into, any Person
or transfer all or substantially all of its properties or assets to any Person.
This Agreement shall inure to the benefit of and be binding upon the Company and
the Employee, their respective successors, executors, administrators, heirs and
permitted assigns.

       15.    SEVERABILITY. If any portion or provision of this Agreement shall
to any extent be declared illegal or unenforceable by a court of competent
jurisdiction, then the remainder of this Agreement, or the application of such
portion or provision in circumstances other than those as to which it is so
declared illegal or unenforceable, shall not be affected thereby, and each
portion and provision of this Agreement shall be valid and enforceable to the
fullest extent permitted by law.

       16.    WAIVER. No waiver of any provision hereof shall be effective
unless made in writing and signed by the waiving party. The failure of either
party to require the performance of any term or obligation of this Agreement, or
the waiver by either party of any breach of this Agreement, shall not prevent
any subsequent enforcement of such term or obligation or be deemed a waiver of
any subsequent breach.

       17.    NOTICES. Any and all notices, requests, demands and other
communications provided for by this Agreement shall be in writing and shall be
effective when delivered in person, deposited in the United States mail, postage
prepaid, registered or certified, or consigned to a national overnight courier
and addressed to the Employee at his last known address on the books of the
Company or, in the case of the Company, at its principal place of business,
attention of the Chair of the Board, or to such other address as either party
may specify by notice to the other actually received.

       18.    ENTIRE AGREEMENT. This Agreement constitutes the entire agreement
between the parties and supersedes all prior communications, agreements and
understandings, written or oral, with respect to the terms and conditions of the
Employee's employment; provided, however, that this Agreement shall not
terminate or supersede any additional obligations of the Employee pursuant to
the Original Agreement or any other agreement with respect to the confidential
information or the like or with respect to any restrictions on the activities of
the Employee or with respect to the securities of the Company.

       19.    AMENDMENT. This Agreement may be amended or modified only by a
written instrument signed by the Employee and by a expressly authorized
representative of the Company.

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       20.    HEADINGS. The headings and captions in this Agreement are for
convenience only and in no way define or describe the scope or content of any
provision of this Agreement.

       21.    COUNTERPARTS. This Agreement may be executed in two or more
counterparts, each of which shall be an original and all of which together shall
constitute one and the same instrument.

       22.    GOVERNING LAW. This is a Massachusetts contract and shall be
construed and enforced under and be governed in all respects by the laws of the
Commonwealth of Massachusetts, without regard to the conflict of laws principles
thereof.

       23.    ARBITRATION. Any dispute or disagreement between the Employee and
the Company arising under this Agreement shall first be negotiated by the
parties in good faith for up to a period of thirty (30) days and the parties
shall use their best efforts to reach a resolution. In the event that the
parties, for any reason whatever, are unable to reach a resolution with thirty
(30) days, either party may then refer the matter to the American Arbitration
Association for resolution in accordance with the American Arbitration
Association National Rules for the Resolution of Employment Disputes, or any
successor rules. The arbitration shall be conducted in Boston, Massachusetts
before a single arbitrator. The function of the arbitrator shall be to determine
the interpretation and application of the specific provisions of this Agreement
to the issues submitted to arbitration. There shall be no right in arbitration
to obtain, and no arbitrator shall have any authority to award or determine, any
change in, addition to, or detraction from, any of the provisions of this
Agreement. The decision of the arbitrator shall be in writing; shall set forth
the basis for the decision. The decision of the arbitrator acting within the
scope of his/her authority shall be final and binding upon the parties and may
be enforced and executed upon in any court having jurisdiction over the party
against whom enforcement of such award is sought. The parties involved in the
dispute shall divide equally the administrative charges, arbitrator's fees and
related expenses of the arbitration, but each party shall pay its own legal fees
incurred in connection with such arbitration. Nothing contained herein, however,
shall limit the right of the Company or any of its Affiliates to seek equitable
or other relief from any court of competent jurisdiction for violation of any
provision of Section 7, 8 or 9 hereof.

       IN WITNESS WHEREOF, this Agreement has been executed as a sealed
instrument by the Company, by its duly authorized representative, and by the
Employee, as of the date first above written.

THE EMPLOYEE:                                        THE COMPANY

/s/ Alexis Borisy                           By: /s/ Chris Moller
--------------------                            --------------------------
                                            Title: Director
                                                   Chair Compensation
                                                   Committee
                                                   7/12/04

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