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Guide to the Application of Genotyping to Tuberculosis Prevention and Control										Related Pages
										**Acknowledgments**
The contents of this guide represent the dedication and hard work of our TB control community. Numerous people, despite having limited resources and working overtime on numerous competing projects, have contributed to the multiple tasks involved in bringing material of this complexity together into what we hope is a coherent whole. The editors gratefully acknowledge each contributor. We also acknowledge and thank Angie Weaver and Rachel Wilson for their excellent editorial contributions to the guide.
**Editors**
Thomas Navin, MD
National Center for HIV, STD, and TB Prevention
Centers for Disease Control and Prevention
Atlanta, GA
Lisa Rosenblum, MD, MPH
National Center for HIV, STD, and TB Prevention
Centers for Disease Control and Prevention
Atlanta, GA
Charles Wallace, PhD
TB Elimination Division
Texas Department of Health
Austin, TX
Sue Etkind, RN, MS
TB Control and Prevention
Massachusetts Department of Health and Human Service
Jamaica Plain, MA
**Writing Group Members**
Jack Crawford, PhD
National Center for HIV, STD, and TB Prevention
Centers for Disease Control and Prevention
Atlanta, GA
Wendy Cronin, PhD
Maryland State Department of Health and Mental Hygiene
Baltimore, MD
Jeff Driscoll, PhD
Wadsworth Center
New York State Department of Health
Albany, NY
Cynthia Driver, RN, MPH
Epidemiology Office
Bureau of TB Control
New York City Department of Health
New York, NY
Jennifer Flood, MD
California Department of Health Services
Berkeley, CA
Reuben Granich, MD, MPH
National Center for HIV, STD, and TB Prevention
Centers for Disease Control and Prevention
Atlanta, GA
Kashef Ijaz, MD, MPH
National Center for HIV, STD, and TB Prevention
Centers for Disease Control and Prevention
Atlanta, GA
Steve Kammerer
National Center for HIV, STD, and TB Prevention
Centers for Disease Control and Prevention
Atlanta, GA
Peter McElroy, PhD, MPH
National Center for HIV, STD, and TB Prevention
Centers for Disease Control and Prevention
Atlanta, GA
Scott McNabb, PhD, MS
National Center for HIV, STD, and TB Prevention
Centers for Disease Control and Prevention
Atlanta, GA
Tanya Oemig, NRM
Wisconsin Department of Health and Family Services
Madison, WI
Margaret Oxtoby, MD, MPH
Bureau of TB Control
New York State Department of Health
Albany, NY
Walter Page
National Tuberculosis Controllers Association
Atlanta, GA
**Working Group Members**
Tracy Agerton, RN, MPH
TB Control Program
New York City Department of Health
New York, NY
Peter Barnes, MD
Center for Pulmonary and Infectious Disease Control
Departments of Medicine, Cell Biology, and Immunology
University of Texas Health Center
Tyler, TX
Carol Berglund
National Center for HIV, STD, and TB Prevention
Centers for Disease Control and Prevention
Atlanta, GA
Chris Braden, MD
National Center for Infectious Diseases
Centers for Disease Control and Prevention
Atlanta, GA
Bill Burman, MD
Denver Public Health and Hospitals Authority
Denver, CO
Don Cave, PhD
University of Arkansas for Medical Sciences
Little Rock, AR
Jeanne Courval, PhD
National Center for HIV, STD, and TB Prevention
Centers for Disease Control and Prevention
Atlanta, GA
Don Cunningham, BS
Division of Tuberculosis
Arkansas Department of Health
Little Rock, AR
Ed Desmond, PhD
California Department of Health
Berkeley, CA
Loretta H. Gossett, RN, MA
Anne Arundel County Department of Health
Annapolis, MD
Nancy Hooper, BA
Maryland Department of Health and Mental Hygiene
Baltimore, MD
Rosemary Humes, MS, MT (ASCP), SM
Liaison to Association of Public Health Laboratories
Washington, DC
Barry Kreiswirth, PhD
Public Health Research Institute
Newark, NJ
Mark Lobato, MD
National Center for HIV, STD, and TB Prevention
Centers for Disease Control and Prevention
Atlanta, GA
Bereneice M. Madison, PhD
National Center for HIV, STD, and TB Prevention
Centers for Disease Control and Prevention
Atlanta, GA
Beverly Metchock, DrPH
National Center for HIV, STD, and TB Prevention
Centers for Disease Control and Prevention
Atlanta, GA
DeNay Porter-Kirkpatrick, MSN
The University of Alabama at Birmingham
Birmingham, AL
Sandy Price
National Center for HIV, STD, and TB Prevention
Centers for Disease Control and Prevention
Atlanta, GA
Sharon Sharnprapai, MS
State Laboratory Institute
Jamaica Plain, MA
Sumi Sun, MPH
California Department of Health
Berkeley, CA
Zachary Taylor, MD, MPH
National Center for HIV, STD, and TB Prevention
Centers for Disease Control and Prevention
Atlanta, GA
Wanda Walton, MEd, PhD
National Center for HIV, STD, and TB Prevention
Centers for Disease Control and Prevention
Atlanta, GA
Nancy G. Warren, PhD
Bureau of Laboratories
Pennsylvania Department of Health
Lionville, PA
**Technical Consultants**
Gabrielle Benenson, MPH
National Center for HIV, STD, and TB Prevention
Centers for Disease Control and Prevention
Atlanta, GA
Melanie Davis, MS
National Center for HIV, STD, and TB Prevention
Centers for Disease Control and Prevention
Atlanta, GA
Hsin-Hsin Foo, MPH
National Center for HIV, STD, and TB Prevention
Centers for Disease Control and Prevention
Atlanta, GA
Michele Huitric, MPH
National Center for HIV, STD, and TB Prevention
Centers for Disease Control and Prevention
Atlanta, GA
							
					
						Page last reviewed:  September 1, 2012					Content source: 	Division of Tuberculosis Elimination, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention homeGuide to the Application of Genotyping to Tuberculosis Prevention and Control
Acknowledgments
Introduction to Tuberculosis Genotypingplus icon
Introduction to this Guide
Overview of Tuberculosis Genotyping
Overview of the CDC Tuberculosis Genotyping Program
TB Program Eligibility and Application Procedures
Tuberculosis Genotyping Case Studiesplus icon
Investigation of a Genotyping Cluster in a Low-Incidence State
Apparent Genotyping Cluster among Recent Immigrants from the Philippines
False-Positive Culture Investigation
Algorithm to Detect False-Positive Cultures
A Misdiagnosis that was Identified with Genotyping
Genotyping Used to Improve Contact and Cluster Investigations
Identification of Nontraditional Transmission Settings
Investigation of a Multistate Tuberculosis Outbreak
Homeless Shelter Outbreak Investigation
Using Genotyping to Evaluate the Impact of a Screening Program
CDC Tuberculosis Genotyping Laboratory Proceduresplus icon
Science behind Tuberculosis Genotyping
Description of Genotyping Methods
Submission of Isolates
Genotyping Results, Designation of Clusters, and Reporting
Suspected False-Positive Cultures
IS*6110*-based RFLP Analysis
Combining Genotyping and Epidemiologic Data to Improve Our Understanding of TB Transmissionplus icon
Definitions
Reading the Genotyping Laboratory Report
Comparing Genotyping and Epidemiologic Results from Two TB Patients
Comparing Genotyping and Epidemiologic Results from Three or More TB Patients
Clustering as a Surrogate Measure of Recent Transmission
Developing a Tuberculosis Genotyping Programplus icon
Developing a Written Plan
Initial Decisions
Establishing Procedures for:plus icon
Submitting Isolates
Receiving and Acting on Genotyping Results
Requesting RFLP Analysis
Submitting Additional Isolates from the Same Patient
Comparing Genotyping Results between Jurisdictions
False-Positive Cultures
Database Management and Quality Control
Special Issues
Applying Genotyping Results to Tuberculosis Control Practicesplus icon
Evaluating Matching Genotypes
Evaluating Nonmatching Genotypes
Suspected False-Positive Culture Investigations
Expanded Contact Investigations
Outbreak Investigations
Cluster Investigations
Monitoring Trends
Appendicesplus icon
Appendix A: Glossary and Abbreviations
Appendix B: References and Useful Resourcesplus icon
References Cited in the Guide
NTGSN Special Issue References
Information on Packaging and Shipping Infectious Substances
Core Steps of an Outbreak Investigation
Consultants Available to Offer Guidance To receive email updates about this page, enter your email address: Email Address			What's this?				Submit


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