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Tuberculosis (TB)








Reported Tuberculosis in the United States, 2021						Print
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Table 30. Characteristics of Tuberculosis Cases in GENType Clusters1 by Alert Levels Based on Log-Likelihood Ratio (LLR):2 United States, 2019–2021
See Surveillance Slide #62.
Characteristics of clustered tuberculosis cases by log-likelihood ratio-based alert levels.
Characteristics
Unique
Clustered
Alert levels for clustered cases3Non-alerted
Medium
High(LLR <5)
(LLR 5 – <10)
(LLR >=10)No.
(%)
No.
(%)
No.
(%)
No.
(%)
No.
(%)Total
15,025
(80.8)
3,565
(19.2)
2,200
(61.7)
836
(23.5)
529
(14.8)Origin of birth4U.S.-born
3,266
(65.4)
1,726
(34.6)
782
(45.3)
528
(30.6)
416
(24.1)Non-U.S.–born
11,723
(86.5)
1,828
(13.5)
1,409
(77.1)
307
(16.8)
112
(6.1)Unknown or missing
36
(76.6)
11
(23.4)
9
(81.8)
1
(9.1)
1
(9.1)Race and ethnicity5Hispanic or Latino
4,308
(77.1)
1,277
(22.9)
846
(66.2)
292
(22.9)
139
(10.9)American Indian or Alaska Native
85
(45.7)
101
(54.3)
15
(14.9)
21
(20.8)
65
(64.4)Asian
6,098
(88.3)
810
(11.7)
700
(86.4)
100
(12.3)
10
(1.2)Black or African American
2,514
(74.1)
880
(25.9)
385
(43.8)
287
(32.6)
208
(23.6)Native Hawaiian or Other Pacific Islander
112
(47.5)
124
(52.5)
64
(51.6)
30
(24.2)
30
(24.2)White
1,709
(83.9)
329
(16.1)
162
(49.2)
95
(28.9)
72
(21.9)Multiple race
131
(85.6)
22
(14.4)
12
(54.5)
5
(22.7)
5
(22.7)Unknown or missing
68
(75.6)
22
(24.4)
16
(72.7)
6
(27.3)
0
(0.0)Age group, years0–4
66
(38.4)
106
(61.6)
49
(46.2)
37
(34.9)
20
(18.9)5–14
121
(65.8)
63
(34.2)
34
(54.0)
19
(30.2)
10
(15.9)15–24
1,344
(76.4)
416
(23.6)
251
(60.3)
120
(28.8)
45
(10.8)25–44
4,304
(79.2)
1,127
(20.8)
643
(57.1)
294
(26.1)
190
(16.9)45–64
4,468
(79.0)
1,185
(21.0)
726
(61.3)
256
(21.6)
203
(17.1)≥65
4,722
(87.6)
668
(12.4)
497
(74.4)
110
(16.5)
61
(9.1)Disease sitePulmonary only
10,543
(79.6)
2,702
(20.4)
1,620
(60.0)
687
(25.4)
395
(14.6)Extrapulmonary
2,507
(86.2)
403
(13.8)
274
(68.0)
61
(15.1)
68
(16.9)Both
1,967
(81.0)
460
(19.0)
306
(66.5)
88
(19.1)
66
(14.3)Unknown
8
(100.0)
0
(0.0)
0
...
0
...
0
...Sputum smearPositive
7,221
(78.8)
1,941
(21.2)
1,152
(59.4)
491
(25.3)
298
(15.4)Negative
6,092
(83.0)
1,249
(17.0)
836
(66.9)
255
(20.4)
158
(12.7)Not done
1,688
(81.9)
374
(18.1)
211
(56.4)
90
(24.1)
73
(19.5)Unknown or missing
24
(96.0)
1
(4.0)
1
(100.0)
0
(0.0)
0
(0.0)Cavitary disease6Yes
158
(78.6)
43
(21.4)
29
(67.4)
7
(16.3)
7
(16.3)No
1,329
(79.6)
341
(20.4)
232
(68.0)
62
(18.2)
47
(13.8)Unknown or missing
16
(72.7)
6
(27.3)
3
(50.0)
2
(33.3)
1
(16.7)Homeless within past yearYes
510
(61.2)
324
(38.8)
168
(51.9)
75
(23.1)
81
(25.0)No
14,371
(81.8)
3,198
(18.2)
2,010
(62.9)
750
(23.5)
438
(13.7)Unknown or missing
144
(77.0)
43
(23.0)
22
(51.2)
11
(25.6)
10
(23.3)Excess alcohol use within past yearYes
1,109
(67.7)
530
(32.3)
243
(45.8)
153
(28.9)
134
(25.3)No
13,675
(82.2)
2,956
(17.8)
1,907
(64.5)
665
(22.5)
384
(13.0)Unknown or missing
241
(75.3)
79
(24.7)
50
(63.3)
18
(22.8)
11
(13.9)Injecting drug use within past yearYes
107
(51.2)
102
(48.8)
57
(55.9)
26
(25.5)
19
(18.6)No
14,672
(81.3)
3,383
(18.7)
2,093
(61.9)
792
(23.4)
498
(14.7)Unknown or missing
246
(75.5)
80
(24.5)
50
(62.5)
18
(22.5)
12
(15.0)Noninjecting drug use within past yearYes
771
(57.3)
575
(42.7)
266
(46.3)
152
(26.4)
157
(27.3)No
14,009
(82.8)
2,913
(17.2)
1,891
(64.9)
663
(22.8)
359
(12.3)Unknown or missing
245
(76.1)
77
(23.9)
43
(55.8)
21
(27.3)
13
(16.9)Resident of a correctional facility at time of diagnosisYes
296
(69.0)
133
(31.0)
50
(37.6)
27
(20.3)
56
(42.1)No
14,632
(81.1)
3,403
(18.9)
2,128
(62.5)
805
(23.7)
470
(13.8)Unknown or missing
97
(77.0)
29
(23.0)
22
(75.9)
4
(13.8)
3
(10.3)HIV statusPositive
604
(77.3)
177
(22.7)
92
(52.0)
39
(22.0)
46
(26.0)Negative
12,811
(80.3)
3,135
(19.7)
1,943
(62.0)
735
(23.4)
457
(14.6)Refused
313
(88.9)
39
(11.1)
22
(56.4)
15
(38.5)
2
(5.1)Not offered
923
(84.7)
167
(15.3)
113
(67.7)
38
(22.8)
16
(9.6)Unknown, missing or indeterminate
374
(88.8)
47
(11.2)
30
(63.8)
9
(19.1)
8
(17.0)Multidrug-resistant TBYes
179
(81.0)
42
(19.0)
28
(66.7)
7
(16.7)
7
(16.7)No
14,414
(80.7)
3,444
(19.3)
2,126
(61.7)
810
(23.5)
508
(14.8)Unknown or missing
432
(84.5)
79
(15.5)
46
(58.2)
19
(24.1)
14
(17.7)1GENType clusters have two or more cases with matching spoligotype and 24-locus mycobacterial interspersed repetitive unit-variable number tandem repeat (MIRU-VNTR) type within a county during the specified 3-year time period.2Alert levels are based on a log-likelihood ratio, which calculates the geographical concentration of a genotype in a county compared to the rest of the country during a 3-year period.3There were 3,565 cases in 1,241 clusters: 529 cases were in 56 (4.5%) high alert clusters; 836 cases were in 279 (22.5%) medium alert clusters, and 2,200 cases were in 906 (73.0%) non-alert clusters.4Persons born in the United States, certain U.S. territories, or elsewhere to at least one U.S. citizen parent are categorized as U.S.-born. All other persons are categorized as non-U.S.–born.5Persons who identified as Hispanic or Latino were categorized as “Hispanic or Latino,” regardless of self-reported race. Persons who did not identify as Hispanic or Latino were categorized by self-reported race; if more than one race was reported, the person was categorized as “Multiple race.”6Cavitary disease only assessed for persons with pulmonary TB and an abnormal x-ray.
**Note:**Ellipses (...) indicate that the percentage cannot be calculated, and the denominator is 0.Table Printing Tips
							
					
							Last Reviewed:  November 29, 2022						Source: 	Division of Tuberculosis Elimination, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention
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