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Exhibit 10.33
 NOTE: Employees or agents of Landlord have no authority to make or agree to make a
lease or any other occupancy agreement relating to the Premises. The submission of this document
for examination and negotiation does not constitute an offer to lease, or a reservation of, or
option for, the Premises, and this document shall become effective and binding only upon the
execution and delivery hereof by both Landlord and Tenant.




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OFFICE LEASE
 TABLE OF EXHIBITS
 ITEM
         EXHIBIT1. Condominium Site Plan
    
    
    A2. Premises Plan
    
    
    B3. Tenant Improvement Drawings and Specifications
    
    
    C4. Property Tax Schedule
    
    
    D5. Rules and Regulations
    
    
    E6. Cleaning Specifications
    
    
    F7. Memorandum of Understanding Letter
    
    
    G8. Additional Insured Endorsement Schedule
    
    
    H
 i




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OFFICE LEASE
 LEASE AGREEMENT
   ARTICLE I REFERENCE DATA
 1.1
    
    SUBJECTS REFERRED TO:
  ALLOWANCE FOR TENANTS WORK:
  ANNUAL BASE RENT:




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ANNUAL RENT:
  BOMA STANDARD:
  BRIGHTON LANDING CONDOMINIUM:
  BROKER(S):
  BUILDING HOLIDAYS:
  CLEANING SPECIFICATIONS:
 Exhibit F
 CONDOMINIUM DOCUMENTS:
  CONDOMINIUM GENERAL COMMON ELEMENTS:
  2




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CONDOMINIUM SITE PLAN:
 Exhibit A
 EAST UNIT:
  EXCESS OPERATING COSTS:
  EXCESS PROPERTY TAXES:
  EXTENSION TERM(S):
  EXTENSION TERM ANNUAL BASE RENT:
  LANDLORD
  LANDLORDS ADDRESS
  LEASE TERM OR TERM:
  LOWER SOUTH BUILDING PARKING GARAGE LIMITED COMMON ELEMENT:
  3




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MANAGING AGENT:
  NORTH PARCEL:
  OPERATING COSTS:
  OPERATING COST BASE YEAR:
  ORIGINAL TERM:
  PERMITTED USES:
  PREMISES:
 Exhibit B
 PROPERTY TAXES:
  4




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PROPERTY TAX BASE YEAR:
  PROPERTY TAX YEAR:
  RENTABLE FLOOR AREA OF THE EAST UNIT:
  RENTABLE FLOOR AREA OF THE PREMISES:
  RENT COMMENCEMENT DATE:
  RULES AND REGULATIONS:
 Exhibit E
 SECURITY DEPOSIT:
  SOUTH BUILDING PARKING GARAGE:
  5




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SOUTH PARCEL:
  TENANT:
  TENANTS ADDRESS (FOR NOTICE AND BILLING):
 Prior to Occupancy of the Premises:
 
 After Occupancy of the Premises:
 
 TENANT IMPROVEMENT DRAWINGS AND SPECIFICATIONS:
 Exhibit C
 TENANT IMPROVEMENT WORK:
  TENANT IMPROVEMENT WORK SCHEDULE:
  TENANTS PERCENTAGE:
  6




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TENANTS SHARE OF EXCESS OPERATING COSTS:
  TENANTS SHARE OF EXCESS PROPERTY TAXES:
  TERM COMMENCEMENT DATE:
  ARTICLE II PREMISES AND TERM
 2.1
    
    DESCRIPTION OF PREMISES.
    7




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2.2
    
    SIGNAGE.
  2.3
    
    TERM.
  2.4
    
    OPTION TO EXTEND.
  2.5
    
    SECURITY DEPOSIT.
  8




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ARTICLE  III  CONSTRUCTION
 3.1
    
    DELIVERY OF PREMISES.
  3.2
    
    PREPARATION OF PREMISES FOR OCCUPANCY.
  3.3
    
    GENERAL PROVISIONS APPLICABLE TO CONSTRUCTION.
   9




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3.4
    
    ALTERATIONS AND ADDITIONS AFTER COMMENCEMENT OF THE TERM.
   10




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3.5
    
    ALLOWANCE FOR TENANTS WORK.
  ARTICLE  IV RENT
 4.1
    
    RENT.
  11




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4.2
    
    RENT DURING EXTENSION TERMS.
   4.3
    
    UTILITIES.
  12




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4.4
    
    TENANTS SHARE OF EXCESS PROPERTY TAXES.
 Exhibit D
 4.5
    
    TENANTS SHARE OF EXCESS OPERATING COSTS.
      13




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14




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15




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16




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4.6
    
    CHANGE OF FISCAL YEAR.
  17




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4.7
    
    PAYMENTS.
  ARTICLE V LANDLORDS COVENANTS DURING THE TERM; LANDLORDS
REPRESENTATIONS AND WARRANTIES
 5.1
    
    LANDLORDS COVENANTS DURING THE TERM.
  Office Buildings Services Exhibit F
 Parking Garage Services
 18




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Additional Services
 Repairs
 Quiet Enjoyment
 Compliance With Laws
 Environmental Notices
 Indemnity
 19




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Eminent Domain Notices
 Insurance
  5.2 INTERRUPTIONS.
  20




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5.3 LANDLORDS REPRESENTATIONS AND WARRANTIES.
  Authority
 Due Execution
 21




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Sole Owner
 No Violations
 Litigation
 Governmental Proceedings
 Access
 Permitted Use
 Permitted Liens
 22




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ARTICLE  VI  TENANTS COVENANTS DURING THE TERM; TENANTS
 REPRESENTATIONS AND WARRANTIES
 6.1 TENANTS COVENANTS DURING THE TERM.
  Tenants Payments
 Repairs and Yielding Up
 Occupancy and Use
 23




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Rules and Regulations
 Safety Appliances
   24




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25




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Indemnity
 Tenants Insurance
 26




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Landlords Right of Entry
 Loading
 Landlords Costs
 27




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Tenants Property
 Labor or Materialpersons Liens
 Changes or Additions
 Holdover
 Security
 28




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Development Impact Agreement
 Boston Residents Employment Exhibit G
 Transportation Access Plan
 6.2 TENANTS REPRESENTATIONS AND WARRANTIES.
  29




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Authority
 Due Execution
 Litigation
 ARTICLE  VII DAMAGE AND DESTRUCTION; CONDEMNATION
 7.1 FIRE OR OTHER CASUALTY
   30




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31




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7.2 EMINENT DOMAIN.
    32




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ARTICLE  VIII  RIGHTS OF HOLDERS OF SECURITY INSTRUMENTS
 8.1 PRIORITY OF LEASE.
  33




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8.2 RIGHTS OF HOLDERS OF SECURITY INSTRUMENTS; LIMITATION OF HOLDERS LIABILITY.
  8.3 HOLDERS ELECTION.
  8.4 NO PREPAYMENT OR MODIFICATION, ETC.
  34




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8.5 NO RELEASE OR TERMINATION.
  8.6 APPROVAL OF LEASE BY LENDER.
  8.7 CONTINUING OFFER.
  ARTICLE  IX  DEFAULT
 9.1 EVENTS OF DEFAULT BY TENANT.
  35




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9.2 TENANTS OBLIGATIONS AFTER TERMINATION.
  36




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9.3 EVENTS OF DEFAULT BY LANDLORD.
  ARTICLE X MISCELLANEOUS
 10.1 NOTICES FROM ONE PARTY TO THE OTHER.
  37




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10.2 BIND AND INURE.
  10.3 NO SURRENDER.
  10.4 NO WAIVER, ETC.
  10.5 NO ACCORD AND SATISFACTION.
  38




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10.6 CUMULATIVE REMEDIES.
  10.7 LANDLORDS RIGHT TO CURE.
  10.8 ESTOPPEL CERTIFICATE.
  39




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10.9 WAIVER OF SUBROGATION.
  10.10 BROKERAGE.
  10.11 SUBMISSION NOT AN OFFER.
  40




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10.12 APPLICABLE LAW AND CONSTRUCTION.
     10.13 CONFIDENTIALITY
  10.14 NOTICE OF LEASE.
  41




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10.15 INDEPENDENT COVENANTS.
   42




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LANDLORD: BRIGHTON LANDING, LLCBy:Name:
    David C. BrodneyTitle:
    Vice PresidentTENANT: AMICAS, INC.By:Name:Title:




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EXHIBIT A




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EXHIBIT B




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EXHIBIT C




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EXHIBIT D
  Fiscal
    
    East Unit Tax Per
    
    South Unit Tax
    
    Total East Unit
    
    Excess PropertyProperty Tax
    
    Rentable Square
    
    Allocation
    
    Tax Per Rentable
    
    Taxes Per SquareYear
    
    Foot
    
    (38.77%)
    
    Square Foot
    
    Foot2008
    
    
    3.43
    
    
    
    0.57
    
    
    
    4.00
    
    
    
    0.002009
    
    
    3.58
    
    
    
    0.59
    
    
    
    4.17
    
    
    
    0.172010
    
    
    3.74
    
    
    
    0.61
    
    
    
    4.35
    
    
    
    0.352011
    
    
    3.91
    
    
    
    0.63
    
    
    
    4.54
    
    
    
    0.542012
    
    
    4.08
    
    
    
    0.66
    
    
    
    4.74
    
    
    
    0.74
 Note:




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EXHIBIT E
  1.
    
    The entrances, lobbies, passages, corridors, elevators, halls, courts, sidewalks, vestibules,
and stairways shall not be encumbered or obstructed by Tenant, Tenants agents, servants,
employees, licensees or visitors or used by them for any purposes other than ingress or egress
to and from the Premises. Brighton Landing and the surrounding common areas are a non-smoking
facility and Tenants will cooperate to ensure that its employees comply with this regulation.
 2.
    
    Tenant, or the employees, agents, servants, visitors or licensees of Tenant shall be directed
to use the Smoking Shelter and no other location on the Brighton Landing Campus for the
purpose of smoking.  Chairs and ash urns will be appropriately placed in and about the
shelter.
 3.
    
    The moving in or out of all safes, freight, furniture, or bulky matter of any description
shall take place during the hours, which Landlord may determine from time to time. Landlord
reserves the right to inspect all freight and bulky matter to be brought into the Premises.
Landlord reserves the right to have Landlords structural engineer review Tenants floor loads
on the Premises at Tenants expense.
 4.
    
    Tenant, or the employees, agents, servants, visitors or licensees of Tenant shall not, at any
time or place, leave or discard any rubbish, paper, articles, or objects of any kind
whatsoever outside the doors of the Premises or in the corridors or passageways of the
Premises. No animals or birds shall be brought or kept in or about the Premises. Bicycles
shall not be permitted in the buildings.
 5.
    
    Tenant shall not place objects against glass partitions or doors or windows or adjacent to
any common space which would be unsightly from the Premises corridors or from the exterior of
the Premises and will promptly remove the same upon notice from Landlord.
 6.
    
    Tenant shall not make noises, cause disturbances, create vibrations, odors or noxious fumes
or use or operate any electric or electrical devices or other devices that emit sound waves or
are dangerous to other tenants and occupants of the Premises or that would interfere with the
operation of any device or equipment or radio or television broadcasting or reception from or
within the Premises or elsewhere, or with the operation of roads or highways in the vicinity
of the Premises, and shall not place or install any projections, antennae, aerials, or similar
devices inside or outside of the Premises, without the prior written approval of Landlord.
 7.
    
    Tenant may not (without Landlords approval therefore, which approval will be signified on
Tenants Plans submitted pursuant to the Lease) and Tenant shall not permit or suffer anyone
to: (a) cook (which term shall not be deemed to include ordinary use of a conventional
microwave oven) in the Premises; (b) place vending or dispensing machines of any kind in or
about the Premises, except for food products and beverages in a manner compatible with the use
of the Premises for office purposes; (c) at any time to sell, purchase or give away, or permit
the sale, purchase, or gift of food in any form.




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8.
    
    Tenant shall not: (a) use the Premises for lodging, manufacturing or for any immoral or
illegal purposes; or (b) use the Premises to engage in the manufacture or (c) use the Premises
to engage in the manufacture or sale of, or for the use of, illegal drugs.
 9.
    
    No awning or other projections shall be attached to the outside walls or windows. No
curtains, blinds, shades, screens or signs visible from the exterior of the Premises, other
than those furnished by Landlord, shall be attached to, hung in, or used in connection with
any window or door of the Premises without prior written consent of Landlord.
 10.
    
    No signs, advertisement, object, notice or other lettering shall be exhibited, inscribed,
painted or affixed on any part of the outside or inside of the Premises if visible from
outside of the Premises.
 11.
    
    Landlord will furnish door keys for doors in the Premises at the Commencement of the Lease.
Tenant shall not affix additional locks on doors and shall purchase duplicate keys only from
Landlord. In the event of the loss of any keys so furnished by Landlord, Tenant shall pay to
Landlord the cost thereof.
 12.
    
    Tenant shall cooperate and participate in all reasonable and customary security programs
affecting the Premises.
 13.
    
    Tenant assumes responsibility for protecting its space from theft, robbery and pilferage,
which includes keeping doors locked and other means of entry to the Premises closed and
secured.
 14.
    
    Tenant shall not make any room-to-room canvass to solicit business from other tenants in the
Premises, and shall not exhibit, sell or offer to sell, use, rent or exchange any item or
services in or from the Premises on a retail basis unless such use is specified in its Lease.
Canvassing, soliciting and peddling in the Premises are prohibited and Tenant shall cooperate
to prevent the same. Peddlers, solicitors and beggars shall be reported to the Leasing and
Management Office.
 15.
    
    Tenant shall not install any resilient tile or similar floor covering in the Premises except
with the prior written approval of Landlord, which approval shall not be unreasonably
withheld. The use of the cement or other similar adhesive material is expressly prohibited.
 16.
    
    Tenant shall not waste electricity or water and agrees to cooperate fully with Landlord to
assure the most effective operation of the Premises heating and air conditioning system and
shall refrain from attempting to adjust controls, except with respect to thermostats, if any,
located within the Premises. Tenant shall keep corridor doors closed except when being used
for access.
 17.
    
    The water and wash closets and other plumbing fixtures shall not be used for any purposes
other than those for which they were constructed, and no sweepings, rubbish rags, or other
substances shall be thrown therein.




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18.
    
    Premises employees shall not be required to perform, and shall not be requested by any tenant
or occupant to perform, any work outside of their regular duties, unless under specific
instructions from the office of the Leasing and Management Office of the Premises.
 19.
    
    Tenant may request heating and/or air conditioning during other periods in addition to normal
working hours by submitting its request in writing to the office of the Leasing and Management
Office of the Premises no later than 2:00 p.m. the preceding work day (Monday through Friday)
on forms available from the Leasing and Management Office. The request shall clearly state the
start and stop hours of the off-hour service. Tenant shall submit to the Leasing and
Management Office a list of personnel authorized to make such request. The Tenant shall be
charged for such operation in the form of additional rent; such charges are to be determined
by the Leasing and Management Office and shall be fair and reasonable and reflect the actual
additional operating costs involved.
 20.
    
    Tenant covenants and agrees that its use of the Premises shall not cause a discharge of more
than its pro rata share on a square foot basis of the design flow gallonage per day of
sanitary (non-industrial) sewage for the Premises as disclosed to and approved by Tenant prior
to the Term Commencement Date. Discharges in excess of that amount, and any discharge of
industrial sewage, shall only be permitted if Tenant, at its sole expense, shall have obtained
all necessary permits and licenses therefore, including without limitation permits from state
and local authorities having jurisdiction thereof. If Tenant uses any materials other than
ordinary cleaning solvents and other substances routinely used by office tenants in office
buildings like the Premises, all of which must be used by Tenant in strict compliance with any
applicable legal requirements, then Tenant shall submit to Landlord on December 31 of each
year of the Term of this Lease a statement, certified by an authorized officer of Tenant,
which contains the following information: name of all chemical, gases, and hazardous
substances, used, generated, or stored on the Premises; type of substance (liquid, gas or
granular); quantity used, stored or generated per year; method of disposal; permit number, if
any, attributable to each substance, together with copies of all permits for such substance;
and permit expiration date for each substance.




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EXHIBIT F
  I.
    
    Main Lobby and EntrancesDaily emptying of trash, vacuuming of carpeted areas, spot cleaning, sweeping, and damp
mopping of hard surface floors, cleaning of glass and horizontal surfaces, wiping and
polishing of elevator doors and other metal and hard surfaces.Weekly, monthly or quarterly wiping of all horizontal surfaces, moldings, window ledges,
lighting fixtures, high dusting in lobbies, stairwells and vestibules.II.
    
    ElevatorsDaily vacuuming, cleaning of walls and doors, polishing of tracks and doors.Weekly, monthly or quarterly edge vacuuming, ceiling polishing, panel dusting and cleaning.III.
    
    Receiving AreasDaily sweeping and mopping of floors. Walls and doors to be washed.Monthly pressure washing of floors and loading platforms.IV.
    
    Corridors, Stairs, Common AreaDaily vacuuming, spot cleaning and wiping.Weekly or monthly dusting of railings, horizontal and vertical surfaces, high areas and
heating and A/C diffusers. Damp mopping of stairs, edge vacuuming and hot water pressure
extraction for carpeting.V.
    
    Restrooms and ShowersDaily emptying of receptacles, replacement of liners, cleaning and polishing of stainless
steel, cleaning and sanitizing of urinals, sinks, toilets and showers, polishing of mirrors
and chrome, sweeping and mopping of floors, spot cleaning and dusting, washing of tiles and
partitions. Quarterly machine scrubbing of floors with a germicidal solution.VI.
    
    Office, Administrative Areas and Conference RoomsDaily emptying of trash receptacles, replacement of liners, sweeping and damp mopping of
hard surface floors, spot cleaning of carpets, vacuuming of all carpets, horizontal and
vertical dusting and spot cleaning.




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Weekly or monthly vacuuming of hard to reach areas, dusting of window sills, venetian
blinds, counters, desks, tabletops, bookcases, and file cabinets.VII.
    
    Main Cafeteria and Tenant KitchenettesDaily emptying of trash receptacles, replacement of liners, vacuuming of carpets, spot
cleaning, dusting and sanitizing of horizontal and vertical surfaces, cleaning of
appliances, sweeping and damp mopping of floors.Weekly, monthly or quarterly washing interior/exterior of receptacles, high speed floor
buffing, scrubbing of tiled floors.




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EXHIBIT G




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EXHIBIT H
  Named as Certificate Holder on Certificate of Insurance
 
 Named as Additional Insured