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*Treponema pallidum* Requests by Commercial Companies																									Related Pages
												CDC’s Division of STD Prevention is making available a *Treponema pallidum* subspecies *pallidum* (*T. pallidum*) strain propagated in rabbits for research and development purposes. The cultures are intended solely for companies developing and/or seeking FDA approval of syphilis diagnostic tests in the United States.
This page provides information on how to obtain *T. pallidum* cultures from the CDC.
All requests require approval by the CDC Division of STD Prevention Laboratory Branch Chief or designee. A Material Transfer Agreement (MTA) between CDC and the requestor is required before cultures will be shipped. CDC will access a usage fee of $200 per vial of culture to recover some of the costs for strain propagation, storage and shipping.
Details on CulturesEach culture is a crude extract and will be provided in 0.5 ml – 1 ml frozen aliquots at a concentration of approximately 104 to 107 treponemes/ml.
CDC may provide up to 5 vials per request. If additional vials are required then the order will be fulfilled when stocks are replenished.
CDC will assign a CDC Unique Identifier (CUID) to each vial of culture. Any future queries regarding the culture must reference this CUID.How to Request CulturesSubmit a request by sending an e-mail to CDC at stdlaboratoryspecim@cdc.gov for attention of Dr. Allan Pillay.
Once CDC confirms that the culture is available, submit a letter on your company letterhead with the following information:
State the purpose for requesting the culture;
State that you agree to pay $200 per vial of *T. pallidum* culture;
Confirm that your facility can safely work with Biosafety Level 2 pathogens;
Indicate if a live or heat inactivated culture is required; and
Include affiliation and complete contact information of the requestor.
Please note that payment is required before shipping of cultures.**Disclaimer: CDC will not be responsible for loss of viability of cultures due to shipping conditions or delays.**

			
							
								Page last reviewed:  October 31, 2018						Content source:  	Division of STD Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention homeSyphilis
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