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Reported Tuberculosis in the United States, 2021						Print
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Table 18. Percentages of Tuberculosis Cases by Initial Drug Regimen, Method of Administration, and Completion of Therapy (COT): United States, 1993–2021
See Surveillance Slides #42, #43, #44, #45  and #46.
Percentages of tuberculosis by initial drug regimen, method of administration and completion of therapy.
**Year**
**Total cases1**
**Initial drug regimen2**
**Method of administration3, 4**
**Therapy ≤1 year indicated5****HRZE6**
**Multi (4+) drug regimen7**
**No.**
**DOT only**
**Both DOT and SAT**
**No.**
**COT ≤1 year**
**COT ever****No.**
**(%)**
**No.**
**(%)**
**No.**
**(%)**
**No.**
**(%)**
**No.**
**(%)**
**No.**
**(%)**2021
7,604
6,330
(83.2)
794
(10.4)
––
––
––
––
––
––
––
––
––
––2020
6,955
5,801
(83.4)
745
(10.7)
––
––
––
––
––
––
––
––
––
––2019
8,665
7,177
(82.8)
1,017
(11.7)
8,632
5,241
(62.2)
2,778
(33.0)
7,189
6,460
(89.9)
6,863
(95.5)2018
8,786
7,287
(82.9)
1,029
(11.7)
8,738
5,269
(61.2)
2,903
(33.7)
7,355
6,574
(89.4)
7,048
(95.8)2017
8,886
7,450
(83.8)
925
(10.4)
8,843
5,357
(61.2)
2,875
(32.8)
7,394
6,686
(90.4)
7,132
(96.5)2016
9,019
7,669
(85.0)
913
(10.1)
8,977
5,660
(63.9)
2,701
(30.5)
7,575
6,768
(89.3)
7,262
(95.9)2015
9,313
7,951
(85.4)
859
(9.2)
9,281
5,997
(65.0)
2,625
(28.5)
7,852
7,083
(90.2)
7,577
(96.5)2014
9,174
7,831
(85.4)
838
(9.1)
9,148
5,786
(63.8)
2,645
(29.1)
7,709
6,959
(90.3)
7,467
(96.9)2013
9,295
7,860
(84.6)
887
(9.5)
9,259
5,753
(63.2)
2,620
(28.8)
7,762
6,974
(89.8)
7,479
(96.4)2012
9,694
8,283
(85.4)
872
(9.0)
9,659
5,826
(61.8)
2,751
(29.2)
8,093
7,298
(90.2)
7,812
(96.5)2011
10,216
8,706
(85.2)
825
(8.1)
10,175
6,161
(62.3)
2,882
(29.1)
8,463
7,594
(89.7)
8,167
(96.5)2010
10,802
9,127
(84.5)
875
(8.1)
10,752
6,315
(59.3)
3,304
(31.0)
9,049
8,107
(89.6)
8,696
(96.1)2009
11,222
9,466
(84.4)
872
(7.8)
11,159
6,603
(59.7)
3,344
(30.2)
9,494
8,434
(88.8)
9,077
(95.6)2008
12,679
10,678
(84.2)
965
(7.6)
12,602
7,038
(56.5)
4,165
(33.4)
11,068
9,532
(86.1)
10,333
(93.4)2007
12,973
10,874
(83.8)
847
(6.5)
12,898
7,192
(56.3)
4,214
(33.0)
11,406
9,747
(85.5)
10,696
(93.8)2006
13,396
11,157
(83.3)
880
(6.6)
13,310
7,612
(57.5)
4,022
(30.4)
11,645
9,868
(84.7)
10,846
(93.1)2005
13,754
11,511
(83.7)
689
(5.0)
13,666
7,840
(57.9)
4,012
(29.6)
11,945
10,029
(84.0)
11,045
(92.5)2004
14,193
11,697
(82.4)
694
(4.9)
14,079
8,181
(58.9)
3,857
(27.8)
12,359
10,414
(84.3)
11,436
(92.5)2003
14,478
11,775
(81.3)
683
(4.7)
14,376
8,051
(56.5)
4,056
(28.5)
12,641
10,562
(83.6)
11,722
(92.7)2002
14,695
11,802
(80.3)
630
(4.3)
14,563
7,972
(55.4)
3,996
(27.8)
12,712
10,543
(82.9)
11,752
(92.4)2001
15,536
12,403
(79.8)
606
(3.9)
15,407
8,159
(53.7)
4,186
(27.5)
13,510
11,141
(82.5)
12,521
(92.7)2000
15,869
12,457
(78.5)
670
(4.2)
15,782
8,190
(52.5)
4,029
(25.8)
13,730
11,280
(82.2)
12,702
(92.5)1999
16,941
13,019
(76.8)
792
(4.7)
16,855
8,182
(49.4)
4,572
(27.6)
14,659
11,931
(81.4)
13,508
(92.1)1998
17,727
13,167
(74.3)
761
(4.3)
17,585
8,240
(47.7)
4,594
(26.6)
15,230
12,370
(81.2)
14,040
(92.2)1997
19,063
13,714
(71.9)
828
(4.3)
18,932
8,702
(47.0)
4,411
(23.8)
16,326
12,849
(78.7)
14,861
(91.0)1996
20,424
13,750
(67.3)
894
(4.4)
20,300
8,437
(42.5)
4,452
(22.4)
17,412
13,369
(76.8)
15,711
(90.2)1995
21,850
13,704
(62.7)
1,058
(4.8)
21,706
7,856
(37.3)
4,532
(21.5)
18,454
13,671
(74.1)
16,461
(89.2)1994
23,197
12,925
(55.7)
1,287
(5.5)
23,053
6,190
(28.1)
4,528
(20.5)
19,452
13,343
(68.6)
16,890
(86.8)1993
23,964
9,664
(40.3)
1,185
(4.9)
23,743
5,052
(21.7)
3,355
(14.4)
19,899
12,621
(63.4)
17,115
(86.0)1Persons alive at diagnosis with initial drug regimen information.2In the 50 U.S. states, New York City, and District of Columbia: In 2021, 70 (0.9%) received no initial drug therapy and 20 (0.3%) were started on one drug.3Persons on an initial drug therapy with at least one drug.4DOT, directly observed therapy; SAT, self-administered therapy.5Excludes patients who died within one year of initiating therapy; patients with an initial isolate resistant to rifampin; patients with bone and joint disease, meningeal disease, or disease of the central nervous system; or patients <15 years of age with miliary disease, positive blood culture, or a positive nucleic acid amplification test on a blood specimen. Beginning in 2011, patients who moved out of the country within one year of initiating therapy were also excluded.6H, isoniazid; R, rifampin; Z, pyrazinamide; E, ethambutol.7A drug regimen with at least four drugs, other than HRZE.
**Note:** Data for all years are updated through July 8, 2022.
Double dashes (––) indicate that data are not available.
See Technical NotesTable Printing Tips
							
					
							Last Reviewed:  November 29, 2022						Source: 	Division of Tuberculosis Elimination, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention
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