Federal Register / Vol. 75, No. 83 / Friday, April 30, 2010 / Notices 22783 

Dated: April 27, 2010. 

Frank Sanders, 

Director, Office of Science Coordination and 

Policy. 

[FR Doc. 2010–10231 Filed 4–29–10; 8:45 am] 

BILLING CODE 6560–50–S 

ENVIRONMENTAL PROTECTION 

AGENCY 

[EPA–HQ–OPP–2010–0378; FRL–8823–4] 

FIFRA Scientific Advisory Panel; 

Notice of Public Meeting 

AGENCY: Environmental Protection 

Agency (EPA). 

ACTION: Notice. 

SUMMARY: There will be a 1–day 

meeting of the Federal Insecticide, 

Fungicide, and Rodenticide Act. 

Scientific Advisory Panel (FIFRA SAP) 

to consider and review a set of scientific 

issues related to the Comparative Adult 

and Juvenile Sensitivity Toxicity 

Protocols for Pyrethroids. 

DATES: The meeting will be held on July 

23, 2010, from 8:30 a.m. to 

approximately 5 p.m. 

Comments. The Agency encourages 

that written comments be submitted by 

July 8, 2010 and requests for oral 

comments be submitted by July 15, 

2010. However, written comments and 

requests to make oral comments may be 

submitted until the date of the meeting, 

but anyone submitting written 

comments after July 8, 2010 should 

contact the Designated Federal Official 

(DFO) listed under FOR FURTHER

INFORMATION CONTACT. For additional 

instructions, see Unit I.C. of the 

SUPPLEMENTARY INFORMATION. 

Nominations. Nominations of 

candidates to serve as ad hoc members 

of FIFRA SAP for this meeting should 

be provided on or before May 14, 2010. 

Webcasting. This meeting may be 

webcast. Please refer to the FIFRA SAP’s 

website, http://www.epa.gov/scipoly/ 

SAP/ for information on how to access 

the webcast. Please note that the 

webcast is a supplementary public 

process provided only for convenience. 

If difficulties arise resulting in 

webcasting outages, the meeting will 

continue as planned. 

Special accommodations. For 

information on access or services for 

individuals with disabilities, and to 

request accommodation of a disability, 

please contact the DFO listed under FOR

FURTHER INFORMATION CONTACT at least 

10 days prior to the meeting to give EPA 

as much time as possible to process 

your request. 

ADDRESSES: The meeting will be held at 

the Environmental Protection Agency, 

Conference Center, Lobby Level, One 

Potomac Yard (South Bldg.), 2777 S. 

Crystal Dr., Arlington, VA 22202. 

Comments. Submit your comments, 

identified by docket identification (ID) 

number EPA–HQ–OPP–2010–0378, by 

one of the following methods: 

• Federal eRulemaking Portal: http:// 

www.regulations.gov. Follow the on-line 

instructions for submitting comments. 

• Mail: Office of Pesticide Programs 

(OPP) Regulatory Public Docket (7502P), 

Environmental Protection Agency, 1200 

Pennsylvania Ave., NW., Washington, 

DC 20460–0001. 

• Delivery: OPP Regulatory Public 

Docket (7502P), Environmental 

Protection Agency, Rm. S–4400, One 

Potomac Yard (South Bldg.), 2777 S. 

Crystal Dr., Arlington, VA. Deliveries 

are only accepted during the Docket 

Facility’s normal hours of operation 

(8:30 a.m. to 4 p.m., Monday through 

Friday, excluding legal holidays). 

Special arrangements should be made 

for deliveries of boxed information. The 

Docket Facility telephone number is 

(703) 305–5805. 

Instructions. Direct your comments to 

docket ID number EPA–HQ–OPP–2010– 

0378. If your comments contain any 

information that you consider to be CBI 

or otherwise protected, please contact 

the DFO listed under FOR FURTHER

INFORMATION CONTACT to obtain special 

instructions before submitting your 

comments. EPA’s policy is that all 

comments received will be included in 

the docket without change and may be 

made available on-line at http:// 

www.regulations.gov, including any 

personal information provided, unless 

the comment includes information 

claimed to be Confidential Business 

Information (CBI) or other information 

whose disclosure is restricted by statute. 

Do not submit information that you 

consider to be CBI or otherwise 

protected through regulations.gov or email. The regulations.gov website is an 

‘‘anonymous access’’ system, which 

means EPA will not know your identity 

or contact information unless you 

provide it in the body of your comment. 

If you send an e-mail comment directly 

to EPA without going through 

regulations.gov, your e-mail address 

will be automatically captured and 

included as part of the comment that is 

placed in the docket and made available 

on the Internet. If you submit an 

electronic comment, EPA recommends 

that you include your name and other 

contact information in the body of your 

comment and with any disk or CD-ROM 

you submit. If EPA cannot read your 

comment due to technical difficulties 

and cannot contact you for clarification, 

EPA may not be able to consider your 

comment. Electronic files should avoid 

the use of special characters, any form 

of encryption, and be free of any defects 

or viruses. 

Docket: All documents in the docket 

are listed in the docket index available 

at http://www.regulations.gov. Although 

listed in the index, some information is 

not publicly available, e.g., CBI or other 

information whose disclosure is 

restricted by statute. Certain other 

material, such as copyrighted material, 

is not placed on the Internet and will be 

publicly available only in hard copy 

form. Publicly available docket 

materials are available either in the 

electronic docket at http:// 

www.regulations.gov, or, if only 

available in hard copy, at the OPP 

Regulatory Public Docket in Rm. S– 

4400, One Potomac Yard (South Bldg.), 

2777 S. Crystal Dr., Arlington, VA. The 

hours of operation of this Docket 

Facility are from 8:30 a.m. to 4 p.m., 

Monday through Friday, excluding legal 

holidays. The Docket Facility telephone 

number is (703) 305–5805. 

Nominations, requests to present oral 

comments, and requests for special 

accommodations. Submit nominations 

to serve as ad hoc members of FIFRA 

SAP, requests for special seating 

accommodations, or requests to present 

oral comments to the DFO listed under 

FOR FURTHER INFORMATION CONTACT. 

FOR FURTHER INFORMATION CONTACT: 

Sharlene R. Matten, DFO, Office of 

Science Coordination and Policy 

(7201M), Environmental Protection 

Agency, 1200 Pennsylvania Ave., NW., 

Washington, DC 20460–0001; telephone 

number: (202) 564–0130; fax number: 

(202) 564–8382; e-mail address: 

matten.sharlene@epa.gov. 

SUPPLEMENTARY INFORMATION: 

I. General Information 

A. Does this Action Apply to Me? 

This action is directed to the public 

in general. This action may, however, be 

of interest to persons who are or may be 

required to conduct testing of chemical 

substances under the Federal Food, 

Drug, and Cosmetic Act (FFDCA), 

FIFRA, and the Food Quality Protection 

Act of 1996 (FQPA). Since other entities 

may also be interested, the Agency has 

not attempted to describe all the specific 

entities that may be affected by this 

action. If you have any questions 

regarding the applicability of this action 

to a particular entity, consult the DFO 

listed under FOR FURTHER INFORMATION

CONTACT. 


wwoods2 on DSK1DXX6B1PROD with NOTICES_PART 1
22784 Federal Register / Vol. 75, No. 83 / Friday, April 30, 2010 / Notices 

B. What Should I Consider as I Prepare 

My Comments for EPA? 

When submitting comments, 

remember to: 

1. Identify the document by docket ID 

number and other identifying 

information (subject heading, Federal 

Register date and page number). 

2. Follow directions. The Agency may 

ask you to respond to specific questions 

or organize comments by referencing a 

Code of Federal Regulations (CFR) part 

or section number. 

3. Explain why you agree or disagree; 

suggest alternatives and substitute 

language for your requested changes. 

4. Describe any assumptions and 

provide any technical information and/ 

or data that you used. 

5. If you estimate potential costs or 

burdens, explain how you arrived at 

your estimate in sufficient detail to 

allow for it to be reproduced. 

6. Provide specific examples to 

illustrate your concerns and suggest 

alternatives. 

7. Explain your views as clearly as 

possible, avoiding the use of profanity 

or personal threats. 

8. Make sure to submit your 

comments by the comment period 

deadline identified. 

C. How May I Participate in this 

Meeting? 

You may participate in this meeting 

by following the instructions in this 

unit. To ensure proper receipt by EPA, 

it is imperative that you identify docket 

ID number EPA–HQ–OPP–2010–0378 in 

the subject line on the first page of your 

request. 

1. Written comments. The Agency 

encourages that written comments be 

submitted, using the instructions in 

ADDRESSES, no later than July 8, 2010, to 

provide FIFRA SAP the time necessary 

to consider and review the written 

comments. Written comments are 

accepted until the date of the meeting, 

but anyone submitting written 

comments after July 8, 2010 should 

contact the DFO listed under FOR

FURTHER INFORMATION CONTACT. Anyone 

submitting written comments at the 

meeting should bring 30 copies for 

distribution to FIFRA SAP. 

2. Oral comments. The Agency 

encourages that each individual or 

group wishing to make brief oral 

comments to FIFRA SAP submit their 

request to the DFO listed under FOR

FURTHER INFORMATION CONTACT no later 

than July 15, 2010, in order to be 

included on the meeting agenda. 

Requests to present oral comments will 

be accepted until the date of the meeting 

and, to the extent that time permits, the 

Chair of FIFRA SAP may permit the 

presentation of oral comments at the 

meeting by interested persons who have 

not previously requested time. The 

request should identify the name of the 

individual making the presentation, the 

organization (if any) the individual will 

represent, and any requirements for 

audiovisual equipment (e.g., overhead 

projector, 35 mm projector, chalkboard). 

Oral comments before FIFRA SAP are 

limited to approximately 5 minutes 

unless prior arrangements have been 

made. In addition, each speaker should 

bring 30 copies of his or her comments 

and presentation slides for distribution 

to the FIFRA SAP at the meeting. 

3. Seating at the meeting. Seating at 

the meeting will be open and on a firstcome basis. 

4. Request for nominations to serve as 

ad hoc members of FIFRA SAP for this 

meeting. As part of a broader process for 

developing a pool of candidates for each 

meeting, FIFRA SAP staff routinely 

solicits the stakeholder community for 

nominations of prospective candidates 

for service as ad hoc members of FIFRA 

SAP. Any interested person or 

organization may nominate qualified 

individuals to be considered as 

prospective candidates for a specific 

meeting. Individuals nominated for this 

meeting should have expertise in one or 

more of the following areas: pyrethroid 

pesticides, rodent and human metabolic 

enzymes and their related ontogeny, in 

vitro pharmacokinetic studies, 

particularly when used in risk 

assessment; voltage-gated sodium 

channels, ontogeny and specificity; 

mode of action and risk assessment, and 

tissue dosimetry. Nominees should be 

scientists who have sufficient 

professional qualifications, including 

training and experience, to be capable of 

providing expert comments on the 

scientific issues for this meeting. 

Nominees should be identified by name, 

occupation, position, address, and 

telephone number. Nominations should 

be provided to the DFO listed under FOR

FURTHER INFORMATION CONTACT on or 

before May 14, 2010. The Agency will 

consider all nominations of prospective 

candidates for this meeting that are 

received on or before this date. 

However, final selection of ad hoc 

members for this meeting is a 

discretionary function of the Agency. 

The selection of scientists to serve on 

FIFRA SAP is based on the function of 

the panel and the expertise needed to 

address the Agency’s charge to the 

panel. No interested scientists shall be 

ineligible to serve by reason of their 

membership on any other advisory 

committee to a Federal department or 

agency or their employment by a 

Federal department or agency except the 

EPA. Other factors considered during 

the selection process include 

availability of the potential panel 

member to fully participate in the 

panel’s reviews, absence of any conflicts 

of interest or appearance of lack of 

impartiality, independence with respect 

to the matters under review, and lack of 

bias. Although financial conflicts of 

interest, the appearance of lack of 

impartiality, lack of independence, and 

bias may result in disqualification, the 

absence of such concerns does not 

assure that a candidate will be selected 

to serve on FIFRA SAP. Numerous 

qualified candidates are identified for 

each panel. Therefore, selection 

decisions involve carefully weighing a 

number of factors including the 

candidates’ areas of expertise and 

professional qualifications and 

achieving an overall balance of different 

scientific perspectives on the panel. In 

order to have the collective breadth of 

experience needed to address the 

Agency’s charge for this meeting, the 

Agency anticipates selecting 

approximately 12–15 ad hoc scientists. 

FIFRA SAP members are subject to 

the provisions of 5 CFR part 2634, 

Executive Branch Financial Disclosure, 

as supplemented by the EPA in 5 CFR 

part 6401. In anticipation of this 

requirement, prospective candidates for 

service on the FIFRA SAP will be asked 

to submit confidential financial 

information which shall fully disclose, 

among other financial interests, the 

candidate’s employment, stocks and 

bonds, and where applicable, sources of 

research support. The EPA will evaluate 

the candidates financial disclosure form 

to assess whether there are financial 

conflicts of interest, appearance of a 

lack of impartiality or any prior 

involvement with the development of 

the documents under consideration 

(including previous scientific peer 

review) before the candidate is 

considered further for service on FIFRA 

SAP. Those who are selected from the 

pool of prospective candidates will be 

asked to attend the public meetings and 

to participate in the discussion of key 

issues and assumptions at these 

meetings. In addition, they will be asked 

to review and to help finalize the 

meeting minutes. The list of FIFRA SAP 

members participating at this meeting 

will be posted on the FIFRA SAP 

website at http://epa.gov/scipoly/sap or 

may be obtained from the OPP 

Regulatory Public Docket at http:// 

www.regulations.gov. 


wwoods2 on DSK1DXX6B1PROD with NOTICES_PART 1
Federal Register / Vol. 75, No. 83 / Friday, April 30, 2010 / Notices 22785 

II. Background 

A. Purpose of FIFRA SAP 

FIFRA SAP serves as the primary 

scientific peer review mechanism of 

EPA’s Office of Chemical Safety and 

Pollution (OCSPP) and is structured to 

provide scientific advice, information 

and recommendations to the EPA 

Administrator on pesticides and 

pesticide-related issues as to the impact 

of regulatory actions on health and the 

environment. FIFRA SAP is a Federal 

advisory committee established in 1975 

under FIFRA that operates in 

accordance with requirements of the 

Federal Advisory Committee Act. FIFRA 

SAP is composed of a permanent panel 

consisting of seven members who are 

appointed by the EPA Administrator 

from nominees provided by the National 

Institutes of Health and the National 

Science Foundation. FIFRA, as 

amended by FQPA, established a 

Science Review Board consisting of at 

least 60 scientists who are available to 

the SAP on an ad hoc basis to assist in 

reviews conducted by the SAP. As a 

peer review mechanism, FIFRA SAP 

provides comments, evaluations and 

recommendations to improve the 

effectiveness and quality of analyses 

made by Agency scientists. Members of 

FIFRA SAP are scientists who have 

sufficient professional qualifications, 

including training and experience, to 

provide expert advice and 

recommendation to the Agency. 

B. Public Meeting 

The Office of Pesticide Programs 

(OPP) is actively working on a 

reevaluation of the human health effects 

of the pyrethroids and pyrethrins under 

the OPP registration review program 

http://www.epa.gov/oppsrrd1/ 

reevaluation/pyrethroidspyrethrins.html required under FIFRA. 

As directed by FQPA, the Agency is to 

make special considerations for pre- and 

post-natal exposures concerning the 

susceptibility of infants and children. 

Guideline studies submitted to the 

Agency for pesticide registration 

address a variety of routes, toxicity 

endpoints, and durations. These studies, 

however, generally do not provide 

direct measures of relative sensitivity 

between adult and juvenile laboratory 

animals. Moreover, the guideline 

studies often do not adequately quantify 

pyrethroid toxicity due to their rapid 

pharmacokinetic time course and modeof-action (i.e., sodium channel 

disruption leading to alterations in 

membrane excitability and firing 

potentials, ultimately resulting in signs 

of neurotoxic behavior). In a February 

16, 2010 letter to the public, EPA asked 

interested parties to voluntarily submit 

study protocols to better understand the 

juvenile sensitivity for synthetic 

pyrethroids and naturally-occurring 

pyrethrins (see pyrethroid docket, EPA– 

HQ–OPP–2008–0331). 

Pyrethroids exert toxicity by 

interfering with the voltage-gated 

sodium channels in the nervous system. 

Ideally, an in vivo measure of sodium 

channel disruption could be evaluated 

in laboratory animals to assess the 

initiating event in the toxicity pathway 

of this class. However, a rapid and 

practical in vivo metric is not likely to 

be available within the Agency’s 

registration review schedule for the 20+ 

pyrethroids that are currently registered. 

The Agency believes that a welldesigned set of in vivo and in vitro 

studies, and possibly in silico studies, 

would provide the Agency with the 

necessary scientific information to 

conduct a risk assessment. The Agency 

has identified some key scientific issues 

which are important in considering 

comparative age sensitivity for this class 

of pesticides such as, 1) the ontogeny of 

hydrolytic and oxidative metabolic 

enzymes; 2) the ontogeny and 

differentiation of sodium channels; 3) 

dose-dependent (high vs. low) effects; 

and 4) rodent to human concordance 

and species sensitivity. 

Proposals submitted by May 21, 2010 

will be reviewed by the Agency and 

presented to the FIFRA SAP for their 

independent evaluation. The Agency is 

asking the SAP to comment on the 

relevance and reliability, as well as the 

strengths and limitations of the proposal 

studies in addressing age-specific 

sensitivity to pyrethroids. Based on the 

recommendations of the SAP and 

comments from the public, the Agency 

will develop a scientifically-based study 

design for use in pyrethroid risk 

characterization. 

C. FIFRA SAP Documents and Meeting 

Minutes 

EPA’s background paper, related 

supporting materials, charge/questions 

to FIFRA SAP, FIFRA SAP composition 

(i.e., members and ad hoc members for 

this meeting), and the meeting agenda 

will be available by late June. In 

addition, the Agency may provide 

additional background documents as the 

materials become available. You may 

obtain electronic copies of these 

documents, and certain other related 

documents that might be available 

electronically, at http:// 

www.regulations.gov and the FIFRA 

SAP homepage at http://www.epa.gov/ 

scipoly/sap. 

FIFRA SAP will prepare meeting 

minutes summarizing its 

recommendations to the Agency 

approximately 90–days days after the 

meeting. The meeting minutes will be 

posted on the FIFRA SAP website or 

may be obtained from the OPP 

Regulatory Public Docket at http:// 

www.regulations.gov. 

List of Subjects 

Environmental protection, Pesticides 

and pests. 

Dated: April 27, 2010. 

Frank Sanders, 

Director, Office of Science Coordination and 

Policy. 

[FR Doc. 2010–10229 Filed 4–29–10; 8:45 am] 

BILLING CODE 6560–50–S 

ENVIRONMENTAL PROTECTION 

AGENCY 

[FRL–9143–8] 

Proposed Administrative Settlement 

Agreement Under Section 122 of the 

Comprehensive Environmental 

Response, Compensation, and Liability 

Act for the Chemical Leaman Tank 

Lines, Inc. Superfund Site Located in 

Logan Township, Gloucester County, 

NJ 

AGENCY: Environmental Protection 

Agency (EPA). 

ACTION: Notice of proposed 

administrative settlement and 

opportunity for public comment. 

SUMMARY: The United States 

Environmental Protection Agency 

(‘‘EPA’’) is proposing to enter into an 

administrative settlement agreement 

(‘‘Settlement Agreement’’) with Quality 

Distribution, Inc. (the ‘‘Settling Party’’) 

pursuant to Section 122 of the 

Comprehensive Environmental 

Response, Compensation, and Liability 

Act (‘‘CERCLA’’), 42 U.S.C. 9622. The 

Settlement Agreement provides for 

Settling Party payment of certain 

response costs incurred by EPA at the 

Chemical Leaman Tank Lines, Inc. 

Superfund Site (‘‘Site’’) located in Logan 

Township, Gloucester County, New 

Jersey. 

In accordance with Section 122(i) of 

CERCLA, 42 U.S.C. 9622(i), this notice 

is being published to inform the public 

of the proposed Settlement Agreement 

and of the opportunity to comment. For 

thirty (30) days following the date of 

publication of this notice, EPA will 

receive written comments relating to the 

proposed Settlement Agreement. EPA 

will consider all comments received and 

may modify or withdraw its consent to 

the settlement if comments received 

disclose facts or considerations that 


wwoods2 on DSK1DXX6B1PROD with NOTICES_PART 1