1 Subject: FW: 2009 EHP paper air pollution respiratory effects

Attachments: Windor children EHP paper_Table for Figure 3_June 28 2013.docx

From: Ling Liu [ mailto:Ling.Liu@hc-sc.gc.ca ]

Sent: Friday, June 28, 2013 10:51 AM

To: Patel, Molini

Cc: ling_liu@hc-sc.gc.ca

Subject: Re: 2009 EHP paper air pollution respiratory effects

Dear Dr. Patel:

As per your request, please see the attached file for the data for Figure 3 in our EHP paper " Acute Effects on Air Pollution on

Pulmonary Function, Airway Inflammation, and Oxidative Stress in Asthmatic Children.” The IQR concentrations of pollutants can be

found in Table 2 of the paper. (See attached file: Windor children EHP paper_Table for Figure 3_June 28 2013.docx)

Hope this would be helpful with your work.

Regards,

Ling Liu, B.MD, M.MD, PhD

Head, Air Health Effects Research Section/

Chef, Section de la recherche sur les effets de la qualité de l'air sur la santé

Healthy Environments & Consumer Safety Branch/

Santé environnementale et sécurité des consommateurs

Health Canada/Santé Canada

A.L. 1915B, 200 Eglantine Drive Way

Ottawa, Ontario, Canada K1A 0K9

Telephone: (613) 952-0945

Email: ling.liu@hc-sc.gc.ca

.............................................................................................

From: "Patel, Molini" < Patel.Molini@epa.gov >

To: " ling_liu@hc-sc.gc.ca " < ling_liu@hc-sc.gc.ca >

Date: 28/06/2013 08:56 AM

Subject: 2009 EHP paper air pollution respiratory effects

Dear Dr. Liu,

Our office is currently developing the Integrated Science Assessment for Nitrogen Oxides and reviewing your 2009 paper in EHP,

“Acute Effects on Air Pollution on Pulmonary Function, Airway Inflammation, and Oxidative Stress in Asthmatic Children.” We are

interested in the two

‐ pollutant modeling results you reported in Figure 3 of the pa per an d hope that you would share with us the

quantitative results (effect estimates and 95% CIs) for FEV1, FEF25

‐ 75%, FeNO, and TBARS. Thank you!

Best regards,

Molini M. Patel, PhD, MPH ;

Epidemiologist

U.S. Environmental Protection Agency

National Center for Environmental Assessment

Mailcode: B243

‐ 01 ;

Research Triangle Park, NC 27711

Phone: 919.541.1492, Fax: 919.541.1818, Email: patel.molini@epa.gov1 Table 6. Percent change (95% confidence interval) in spirometry, FeNO, TBARS and 8

- isoprostane of all asthmatic children , in

association with an interquartile

- range increase of a pollutant (shown in Table 2)

, in one

- and two

- pollutant model s.

Air pollutant PPFEV 1 PPFEF 25

- 75% FeNO TBARS

Single

- pollutant models

SO 2

- 1.1 (

- 2.5, 0.4)

- 3.1(

- 5.8,

- 0.3)

- 3.1 (

- 16.3, 12.2) 36.2 (15.7, 57.2)*

NO 2

- 0.8 (

- 1.8, 0.2)

- 2.8(

- 4.8,

- 0.8) * 0.2 (

- 10.7, 12.5) 21.8 (8.2, 36)*

O 3

- 0.5 (

- 1.9, 0.8)

- 0.2(

- 3.0, 2.7)

- 1.6 (

- 15.3, 14.3) 10.6 (

- 4.2, 26.5)

PM 2.5

- 1.1 (

- 1.9,

- 0.2) *

- 3(

- 4.7,

- 1.2) *

- 0.2 (

- 9.0, 9.3) 24.8 (10.8, 39.4)*

Two

- pollutant models

SO 2

- 0.7(

- 2.4, 1.1)

- 1.3(

- 4.7, 2.3)

- 4.0 (

- 19.8, 14.8) 24.8 (0.5, 50.2)*

NO 2

- 0.5(

- 1.7, 0.8)

- 2.3(

- 4.7, 0.2) 1.4 (

- 12.0, 16.8) 12.9 (

- 3.4, 29.9)

SO 2

- 1(

- 2.4, 0.4)

- 2.9(

- 5.7,

- 0.1) *

- 3.0 (

- 16.3, 12.3) 34.6 (13.5, 56.2)*

O 3

- 0.4(

- 1.7, 1.0) 0.0(

- 2.8, 2.9)

- 1.8 (

- 15.5, 14) 9.5 (

- 4.8, 24.9)

SO 2 1.5(

- 1.2, 4.2) 3.8(

- 1.5, 9.4)

- 10.0 (

- 32.0, 19.1) 25.9 (

- 11.9, 67.0)

PM 2.5

- 1.8(

- 3.4,

- 0.2) *

- 4.9(

- 7.9,

- 1.7) * 5.8 (

- 11.2, 25.9) 9.2 (

- 16.2, 35.6)

NO 2

- 0.9(

- 1.9, 0.1)

- 2.8(

- 4.8,

- 0.8) * 0.4 (

- 10.8, 13.0) 25.2 (10.9, 40.1)*

O 3

- 0.7(

- 2.1, 0.7)

- 0.7(

- 3.5, 2.1)

- 0.7 (

- 14.7, 15.7) 15.4 (0.5, 30.7)*

NO 2 0.4(

- 1.3, 2.0)

- 0.2(

- 3.5, 3.2) 0.0 (

- 17.1, 20.8) 9.5 (

- 11.6, 31.3)

PM 2.5

- 1.3(

- 2.7, 0.2)

- 2.8(

- 5.6, 0.1)

- 0.1 (

- 13.9, 15.9) 16.7 (

- 4.9, 38.9)

O 3

- 0.4(

- 1.7, 1.0) 0.1(

- 2.7, 3.0)

- 1.6 (

- 15.3, 14.2) 9.5 (

- 4.8, 24.9)

PM 2.5

- 1(

- 1.9,

- 0.1) *

- 2.9(

- 4.7,

- 1.1) *

- 0.2 (

- 9, 9.4) 23.8 (9.7, 38.3)*

• Pollutant concentrations were averaged over 3 days including the same day and two days before the clinical testing was done.

• Models were adjusted for testing period, daily temperature, relative humidity, use of SABA and ICS.

• PPFEV 1 : percentage of predicted FEV1; PPFEF 25

- 75% : percentage of predicted FEF 25

- 75% ; FeNO, fractional exhaled nitric

oxide; TBARS, thiobarbituric acid reactive substances.

• Values in parenthesis are 95% confidence interval.

• * , p<0.05