Patent License Agreement



 Exhibit 10.50 
 Text Marked By [* * *] Has Been Omitted Pursuant To A Request For Confidential Treatment And Was Filed Separately With The Securities And Exchange Commission. 

UNIVERSITY of PENNSYLVANIA 

Patent License Agreement 
 This Patent License Agreement (this “Agreement”) is between The Trustees of the University of Pennsylvania, a Pennsylvania nonprofit corporation (“Penn”), and
ImmunoCellular Therapeutics, Ltd., a corporation organized and existing under the laws of Delaware (“Company”). This Agreement is being signed on February 10, 2012 (the “Execution Date”). This Agreement will
become effective on February 10, 2012 (the “Effective Date”). 
 BACKGROUND 

Penn owns certain intellectual property developed by Dr. Brian Czerniecki of Penn’s School of Medicine relating to the
production, use and cryopreservation of dendritic cell cancer vaccines. Penn also owns certain letters patent and/or applications for letters patent relating to the intellectual property. Company desires to obtain a license under the patent
rights to exploit the intellectual property. Penn has determined that the exploitation of the intellectual property by Company is in the best interest of Penn and is consistent with its educational and research missions and goals. 

In consideration of the mutual obligations contained in this Agreement, and intending to be legally bound, the parties agree as follows:

  

	1.	LICENSE 

 1.1
License Grant. Penn grants to Company an exclusive, world-wide license (the “License”) to make, have made, use, import, offer for sale and sell Licensed Products in the Field of Use during the Term (as such terms may be
defined in Sections 1.2 and 6.1). The License includes the right to sublicense as permitted by this Agreement. No other rights or licenses are granted by Penn. 
 1.2 Related Definitions. The term “Licensed Products” means products that are made, made for, used, imported, offered for sale or sold by Company or its Affiliates or sublicensees
and that would (i) in the absence of the License, infringe (or, in the case of pending patent applications, upon issuance, would infringe) at least one claim of the Patent Rights or (ii) use a process or method covered in whole or in part
by a claim of the Patent Rights, whether the claim is issued or pending. The term “Limited Field” means development, production, use, and storage of vaccines for the prevention and/or treatment of breast cancer and ductal carcinoma
in situ. The term “Patent Rights” means all of Penn’s patent rights represented by or issuing from: (a) the United States patents and patent applications listed in Exhibit A that have not been irretrievably lapsed, revoked
or abandoned; (b) any continuation, continuation-in-part (to the 

  
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extent that the claims are directed to inventions which are fully supported by the patents and applications (a) or (b), divisional, re-issue applications, renewals and re-examinations of
(a) or (b); and (c) any foreign counterparts and extensions of (a) or (b). The term “Affiliate” means a legal entity that is controlling, controlled by or under common control with Company and that has executed either
this Agreement or a written joinder agreement agreeing to be bound by all of the terms and conditions of this Agreement. For purposes of this Section 1.2, the word “control” means (x) the direct or indirect ownership of
more than fifty percent (50%) of the outstanding voting securities of a legal entity, (y) the right to receive fifty percent (50%) or more of the profits or earnings of a legal entity, or (z) the right to determine the policy
decisions of a legal entity. The term “Field of Use” means no field restrictions except for the Limited Field. 

1.3 Reservation of Rights by Penn. Penn reserves the right to use and to permit others to use, for any purpose the Patent Rights
other than in the Field of Use, including but not limited to, the Limited Field. Penn reserves the right to use, and to permit other non-commercial entities to use, the Patent Rights in the Field of Use for educational and research purposes.

 1.4 U.S. Government Rights. The parties acknowledge that the United States government retains rights in intellectual
property funded under any grant or similar contract with a Federal agency. The License is expressly subject to all applicable United States government rights, including, but not limited to, any applicable requirement that products, which result from
such intellectual property and are sold in the United States, must be substantially manufactured in the United States. 
 1.5
Sublicense Conditions. The Company’s right to sublicense granted by Penn under the License is subject to each of the following conditions: 
 (a) In each sublicense agreement, Company will prohibit the sublicensee from further sublicensing and require the sublicensee to comply with the terms and conditions of this Agreement. 

(b) Within thirty (30) days after Company enters into a sublicense agreement, Company will deliver to Penn a complete
and accurate copy of the entire sublicense agreement written in the English language. Penn’s receipt of the sublicense agreement, however, will constitute neither an approval of the sublicense nor a waiver of any right of Penn or obligation of
Company under this Agreement. 
 (c) In the event that Company causes or experiences a Trigger Event (as defined
in Section 6.4), all payments due to Company from its Affiliates or sublicensees under the sublicense agreement will, upon notice from Penn to such Affiliate or sublicensee, become payable directly to Penn for the account of Company. Upon
receipt of any such funds, Penn will remit to Company the amount by which such payments exceed the amounts owed by Company to Penn. 
 (d) Company’s execution of a sublicense agreement will not relieve Company of any of its obligations under this Agreement. Company is primarily liable to Penn for any act or omission of an Affiliate
or sublicensee of Company that would be a breach of this Agreement if performed or omitted by Company, and Company will be deemed to be in breach of this Agreement as a result of such act or omission. 

  
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 1.6 No License by Implication. Nothing in this Agreement confers by estoppel
implication or otherwise, any license or rights under any Penn patent other than the Patent Rights, regardless whether such patents are dominant or subordinate to the Patent Rights. 

 

	2.	DILIGENCE 

 2.1
Business Plan. Company will deliver to Penn, within thirty (30) days after the Effective Date, a copy of an initial business plan for the use of the Patent Rights (the “Business Plan”). Thereafter, Company will deliver
to Penn an annual updated Business Plan no later than December 1 of each year during the Term. The Business Plan will include, at a minimum, the information listed in Exhibit B. 

2.2 Company’s Efforts. Company will use commercially reasonable efforts to develop, commercialize, market and sell Licensed
Products in a manner consistent with the Business Plan. 
 2.3 Diligence Events. The Company will use commercially
reasonable efforts to achieve each of the diligence events by the applicable completion date listed in the table below for the first Licensed Product. 
  

			
	 DILIGENCE EVENT
	  	 COMPLETION DATE

	 Delivery to Penn of a completed business plan in a form acceptable to Penn
	  	March 1, 2012
		
	 First dosing of first patient in a Phase III or other pivotal clinical trial for the first Licensed Product
	  	 Twenty-four (24) months

from completion of

current Phase II trial

		
	 Filing of NDA for the first Licensed Product
	  	January 1, 2018
		
	 First Sale of the first Licensed Product
	  	June 30, 2019

 If Penn determines that Company has not fulfilled its obligations under this Section 2.3, Penn shall
furnish Company with written notice of the determination. Within sixty (60) days after receipt of the notice, Company shall either (i) fulfill the relevant obligation or (ii) negotiate with Penn a mutually acceptable schedule of
revised diligence obligations, failing which Penn may, immediately upon written notice to Company, terminate this Agreement or grant additional licenses to third parties to the Patent Rights in the Field of Use. 

 

	3.	FEES AND ROYALTIES 


3.1 License Initiation Fee. In partial consideration of the License, Company will pay to Penn on the Effective Date a
non-refundable, non-creditable license initiation fee of [***]. 
 3.2 License Maintenance Fees. In partial
consideration of the License, Company will pay to Penn, on each anniversary of the Effective Date a license maintenance fee of [***]. License maintenance fees relate to the twelve-month period immediately prior to the anniversary date
on which they are due. 

  
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 3.3 Milestone Payments. In partial consideration of the License, Company will pay to
Penn the applicable milestone payment listed in the table below after achievement of each milestone event for each Licensed Product, whether such milestone event is achieved by Company, its Affiliates or sublicensees. Company will provide Penn with
written notice within thirty (30) days after achieving each milestone. 
  

			
	 MILESTONE
	  	 PAYMENT

	 First dosing of first patient in a Phase II trial for each Licensed Product, not including the ongoing clinical trial NCT01280552
or a Phase I/II study
	  	[***]
		
	 First dosing of first patient in a Phase III clinical trial for each Licensed Product
	  	[***]
		
	 First Sale of each Licensed Product
	  	[***]
		
	 Achievement of [***] in cumulative Sales for each Licensed Product
	  	[***]

 The term “Phase II clinical trial” means studies in humans of the safety, dose ranging
and efficacy of an investigational product that would satisfy the requirements of 21 CFR 312.21(b). 
 The term “Phase
III clinical trial” means a human clinical trial in any country that provides for continued trails of a product on sufficient numbers of patients to establish the safety and efficacy of a product and generate, if required, pharmacoeconomics
data to support regulatory approval in the proposed therapeutic indications as more fully defined in 21 C.F.R. (S) 312.21(c) or equivalent in a foreign country. For clarity, each time a milestone is achieved with respect to a Licensed Product,
then any other milestone payments with respect to earlier milestones that have not yet been paid will be due and payable together with the milestone payment for the milestone that is actually achieved. For additional clarity, milestones are due and
payable on Licensed Products and on products that, upon FDA approval, would become Licensed Products. 
 3.4 Earned
Royalties. In partial consideration of the License, Company will pay to Penn during each Quarter a royalty of (i) [***] of Net Sales on cumulative Net Sales up to [***] for each Licensed Product and (ii) one
and [***] of Net Sales on cumulative Net Sales equal to or exceeding [***] for each Licensed Product. 
 3.5 Related Definitions. The term “Sale” means any bona fide transaction for which consideration is received or expected by Company or its Affiliate or sublicensee for the sale, use, lease,
transfer or other disposition of a Licensed Product to a third party. A Sale is deemed completed at the time that Company or its Affiliate or sublicensee invoices, ships or receives payment for a Licensed Product, whichever occurs first. The term
“Quarter” means each three-month period beginning on January 1, April 1, July 1 and October 1. The term “Net Sales” means the consideration received or expected from, or the fair market value
attributable to, each Sale, less Qualifying Costs that are directly attributable to a Sale, specifically identified on an invoice or other documentation and actually borne by Company or its Affiliates or sublicensees. For purposes of determining Net
Sales, the words “fair market value” mean the cash 

  
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consideration that Company or its Affiliates or sublicensees would realize from an unrelated buyer in an arms length sale of an identical item sold in the same quantity and at the time and place
of the transaction. The term “Qualifying Costs” means: (a) customary discounts in the trade for quantity purchased or for wholesalers and distributors; (b) credits or refunds for claims or returns that do not exceed the original
invoice amount; (c) Company’s bad debt actually written off, net of subsequent recoveries; (d) prepaid outbound transportation expenses and transportation insurance premiums; (e) sales and use taxes and other fees imposed by and
indefeasibly paid to a governmental agency; and (f) Licensed Products provided at or below cost for indigent care or patient assistance programs or administered in clinical trials, except when the recipient is charged for such product; provided
that such Licensed Products do not represent more than [***] of Sales. A Sale is deemed completed at the time that Company or its Affiliate or sublicensee invoices, ships or receives payment for a Licensed Product, whichever occurs
first. The term “Quarter” means each three-month period beginning on January 1, April 1, July 1 and October 1. 
 3.6 Minimum Royalties. In partial consideration of the License, Company will pay to Penn the amount, if any, that the applicable minimum royalty listed in the table below exceeds Company’s
actual aggregate earned royalties for all Licensed Products under Section 3.4 for each year after the first Sale of a Licensed Product. 
  

			
	 Year:
	  	 Each Year

	 MINIMUM:
	  	Aggregate of [***]

 3.7 Sublicense Fees. In partial consideration of the License, Company will pay to Penn a
sublicense fee of (i) [***] of the sum of all payments plus the fair market value of all other consideration of any kind, received by Company from sublicensees for sublicenses involving solely Patent Rights or Penn Technology and
(ii) [***] of the sum of all payments plus the fair market value of all other consideration of any kind, received by Company for all other sublicenses, including, but not limited to, sublicenses involving Patent Rights together
with non-Penn Company owned or controlled intellectual property during the Quarter, other than: (a) royalties paid to Company by a sublicensee based upon Sales by the sublicensee; (b) milestone payments paid to Company by a sublicensee
which Company pays to Penn pursuant to Section 3.3 as a pass through; (c) equity investments in Company by a sublicensee up to the amount of the fair market value of the equity purchased on the date of the investment; (d) loan
proceeds paid to Company by a sublicensee in an arms length, full recourse debt financing to the extent that such loan is not forgiven; (e) sponsored research funding, including clinical research funding, paid to Company by a sublicensee in a
bona fide transaction for future research to be performed by Company; and (f) reimbursements paid to Company by sublicensee for patent costs directly relating to the Patent Rights. 

 

	4.	REPORTS AND PAYMENTS 

 4.1 Royalty Reports. Within forty-five (45) days after the end of each Quarter following the first Sale (or sixty (60) days after the end of each Quarter following the first Sale if
Company has sublicensed the License), Company will deliver to Penn a report, certified by the chief financial officer of Company, detailing the calculation of all royalties, fees and other 

  
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payments due to Penn for such Quarter. The report will include, at a minimum, the following information for the Quarter, each listed by product, by country: (a) the number of units of
Licensed Products constituting Sales; (b) the gross consideration invoiced, billed or received for Sales; (c) the gross amount of any payments and other consideration received by Company from sublicensees and the amounts of any deductions
permitted by Section 3.7; (f) the royalties, fees and other payments owed to Penn, listed by category; and (g) the computations for any applicable currency conversions. Each royalty report will be substantially in the form of the
sample report attached as Exhibit C. 
 4.2 Payments. Company will pay all royalties, fees and other payments due
to Penn under Sections 3.3, 3.4, 3.6, and 3.7, and within forty-five (45) days after the end of the Quarter (or sixty (60) days after the end of the Quarter if Company has sublicensed the License) in which the royalties, fees or other
payments accrued. 
 4.3 Records. Company will maintain, and will cause its Affiliates and sublicensees to maintain,
complete and accurate books, records and related background information to verify Sales, and all of the royalties, fees, and other payments due or paid under this Agreement, as well as the various computations reported under Section 4.1. The
records for each Quarter will be maintained for at least five (5) years after submission of the applicable report required under Section 4.1. 
 4.4 Audit Rights. Upon reasonable prior written notice to Company, Company and its Affiliates and sublicensees will provide Penn and its accountants with access to all of the books, records, key
personnel and related background information required by Section 4.3 to conduct a review or audit of Sales, and all of the royalties, fees, and other payments payable under this Agreement. Access will be made available: (a) during normal
business hours; (b) in a manner reasonably designed to facilitate Penn’s review or audit without unreasonable disruption to Company’s business; and (c) no more than once each calendar year during the Term (as defined below) and
for a period of five (5) years thereafter. Company will promptly pay to Penn the amount of any underpayment determined by the review or audit, plus accrued interest. If the review or audit determines that Company has underpaid any payment by
five percent (5%) or more, then Company will also promptly pay the costs and expenses of Penn and its accountants in connection with the review or audit. In addition, once annual Sales of Licensed Products exceed Fifty Million ($50,000,000),
Company will conduct, at Penn’s request, no more than once every two (2) years, at its own expense, an independent audit of Sales, and all of the royalties, fees, and other payments due or paid under this Agreement. Promptly after
completion of the audit, Company will provide to Penn a copy of the report of the independent auditors along with any underpayments and interest thereon. 
 4.5 Currency. All dollar amounts referred to in this Agreement are expressed in United States dollars. All payments will be made in United States dollars. If Company receives payment from a third
party in a currency other than United States dollars for which a royalty or fee is owed under this Agreement, then (a) the payment will be converted into United States dollars at the conversion rate for the foreign currency as published in the
eastern edition of the Wall Street Journal as of the last business day of the Quarter in which the payment was received by Company, and (b) the conversion computation will be documented by Company in the applicable report delivered to Penn
under Section 4.1. 

  
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 4.6 Place of Payment. All payments by Company are payable to “The Trustees of
the University of Pennsylvania” and will be made to the following addresses: 
  

					
	 By Electronic Transfer:
	  	 By Check (direct mail):
	  	 By Check (lockbox):

			
	 [***]
	  	 The Trustees of the University of Pennsylvania
 c/o Center for Technology Transfer
 Center for

Technology Transfer
 Attention: Financial
Coordinator
	  	 The Trustees of the University of Pennsylvania
 c/o Center for Technology Transfer
 PO Box 785546

Philadelphia, PA 19178-5546


 4.7 Interest. All amounts that are not paid by Company when due will accrue interest from the date
due until paid at a rate equal to one and one-half percent (1.5%) per month (or the maximum allowed by law, if less). 
  

	5.	CONFIDENTIALITY AND USE OF PENN’S NAME 

 5.1 Confidentiality Agreement. In connection with the execution of this Agreement, the parties will enter into a Confidential Disclosure Agreement substantially similar to Penn’s standard form
as attached hereto as Exhibit D. 
 5.2 Other Confidential Matters. Penn is not obligated to accept any confidential
information from Company, except for the reports required by Sections 2.1, 4.1, 4.4 and 6.6. Penn, acting through its Center for Technology Transfer and finance offices, will use reasonable efforts not to disclose to any third party outside of Penn
any confidential information of Company contained in those reports, for so long as such information remains confidential. Penn bears no institutional responsibility for maintaining the confidentiality of any other information of Company. Company may
elect to enter into confidentiality agreements with individual investigators at Penn that comply with Penn’s internal policies. The provisions of this Section 5.2 shall not limit Penn’s obligations to Company or Company’s
obligations to Penn under any other agreement, including confidentiality agreement, between the parties relating to transactions other than the License. 
 5.3 Use of Penn’s Name. Company and its Affiliates, sublicensees, employees, and agents may not use the name, logo, seal, trademark, or service mark (including any adaptation of them) of Penn
or any Penn school, organization, employee, student or representative, without the prior written consent of Penn. 

  
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	6.	TERM AND TERMINATION 

 6.1 Term. This Agreement will commence on Effective Date and terminate upon the later of: (a) the expiration or abandonment of the last patent to expire or become abandoned of the Patent
Rights; or (b) ten (10) years after the first Sale of the first Licensed Product if no patent has issued from the Patent Rights (as the case may be, the “Term”). Upon the expiration or abandonment of all Patent Rights in
any country during the Term no royalties shall be payable under this Agreement thereafter based on Sales in that country. 
 6.2
Early Termination by Company. Company may terminate this Agreement at any time effective upon completion of each of the following conditions: (a) providing at least sixty (60) days prior written notice to Penn of such intention to
terminate; (b) ceasing to make, have made, use, import, offer for sale and sell all Licensed Products; (c) terminating all sublicenses and causing all Affiliates and sublicensees to cease making, having made, using, importing, offering for
sale and selling all Licensed Products; and (d) paying all amounts owed to Penn under this Agreement and any sponsored research agreement between Penn and Company related to the Patent Rights, through the effective date of termination.

 6.3 Early Termination by Penn. Penn may terminate this Agreement if: (a) Company is more than thirty
(30) days late in paying to Penn any amounts owed under this Agreement and does not immediately pay Penn in full, including accrued interest, upon written demand (a “Payment Default”); (b) other than a Payment Default,
Company or its Affiliate or sublicensee materially breaches this Agreement and does not cure the breach within forty-five (45) days after written notice of the breach; or (c) Company or its Affiliates or sublicensee experiences a Trigger
Event, and in the case of sublicensee, Company has not terminated the sublicense prior to or automatically upon the occurrence of the Trigger Event. If a sublicensee materially breaches the applicable sublicense agreement, Company will take
reasonable steps to enforce the terms of such sublicense agreement against such sublicensee 
 6.4 Trigger Event. The
term “Trigger Event” means any of the following: (a) a material default by Company under any sponsored research agreement or option or license agreement between Company and Penn related to the Patent Rights (whether entered
prior to, contemporaneous with, or subsequent to the Effective Date) that is not cured within the cure period, if any, set forth in such agreement or a material default under either of the Option Agreement (“Option Agreement”) or
the Know-How License (“Know-How License”), each by and between Company and Penn pursuant to the Option Agreement ; (b) if Company or its Affiliate or sublicensee (i) becomes insolvent, bankrupt or generally fails to pay
its debts as such debts become due, (ii) is adjudicated insolvent or bankrupt; (iii) admits in writing its inability to pay its debts, (iv) suffers the appointment of a custodian, receiver or trustee for it or its property and, if
appointed without its consent, not discharged within thirty (30) days; (v) makes an assignment for the benefit of creditors; or (vi) suffers proceedings being instituted against it under any law related to bankruptcy, insolvency,
liquidation or the reorganization, readjustment or release of debtors and, if contested by it, not dismissed or stayed within ten(10) days; (c) the institution or commencement by Company or its Affiliate or sublicensee of any proceeding under
any law related to bankruptcy, insolvency, liquidation or the reorganization, readjustment or release of debtors; (d) the entering of any order for relief relating to any of the proceedings described in Section 6.4(b) or (c) above;
(e) the calling by Company or its Affiliate or sublicensee of a meeting of its creditors with a view to arranging a composition or adjustment of its debts; (f) the act or failure to act by Company or its Affiliate or sublicenseeindicating
its 

  
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consent to, approval of or acquiescence in any of the proceedings described in Section 6.4(b) – (e) above; (g) failure by Company to pay patent expenses ; or (h) the
commencement by Company of any action against Penn, including an action for declaratory judgment, to declare or render invalid or unenforceable the Patent Rights, or any claim thereof. 

6.5 Effect of Termination. Upon the termination of this Agreement for any reason: (a) the License terminates;
(b) Company and all its Affiliates and sublicensees will cease all making, having made, using, importing, offering for sale and selling all Licensed Products, except to extent permitted by Section 6.6; (c) Company will pay to Penn all
amounts, including accrued interest, owed to Penn under this Agreement and any sponsored research agreement related to the Patent Rights, the Option Agreement and the Know-How License through the date of termination, including royalties on Licensed
Products invoiced or shipped through the date of termination and any sell off period permitted by Section 6.6, whether or not payment is received prior to termination or expiration of the sell off period permitted by Section 6.6;
(d) Company will, at Penn’s request, return to Penn all confidential information of Penn and provide to Penn a development summary directly related to Licensed Products generated by Company during the Term that will facilitate the further
development of the technology licensed under this Agreement; and (e) in the case of termination under Section 6.3, all duties of Penn and all rights (but not duties) of Company under this Agreement immediately terminate without further
action required by either Penn or Company. 
 6.6 Inventory & Sell Off. Upon the termination of this Agreement
for any reason, Company will cause physical inventories to be taken immediately of: (a) all completed Licensed Products on hand under the control of Company or its Affiliates or sublicensees; and (b) such Licensed Products as are in the
process of manufacture and any component parts on the date of termination of this Agreement. Company will deliver promptly to Penn a copy of the written inventory, certified by an officer of the Company. Upon termination of this Agreement for any
reason, Company will promptly remove, efface or destroy all references to Penn from any advertising, labels, web sites or other materials used in the promotion of the business of Company or its Affiliates or sublicensees, and Company and its
Affiliates and sublicensees will not represent in any manner that it has rights in or to the Patent Rights or the Licensed Products. Upon the termination of this Agreement for any reason other than pursuant to Section 6.3(a) or (c), Company may
sell off its inventory of Licensed Products existing on the date of termination for a period of six (6) months and pay Penn royalties on Sales of such inventory within thirty (30) days following the expiration of such six (6) month
period. 
 6.7 Survival. Company’s obligation to pay all amounts, including accrued interest, owed to Penn under
this Agreement will survive the termination of this Agreement for any reason. Sections 13.9, 13.10 and 13.11 and Articles 4, 5, 6, 9, 10, and 11 will survive the termination of this Agreement for any reason in accordance with their respective terms.

  

	7.	PATENT PROSECUTION AND MAINTENANCE 

 7.1 Patent Control. Penn controls the preparation, prosecution and maintenance of the Patent Rights and the selection of patent counsel, with input from Company. For purposes of this Article 7, the
word “maintenance” includes any interference negotiations, claims, or proceedings, in any forum, brought by Penn, Company, a third party, or the United States Patent and Trademark Office, and any requests by Penn or Company that the
United States Patent and Trademark Office reexamine or reissue any patent in the Patent Rights. 

  
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 7.2 Payment and Reimbursement. Within thirty (30) days after the Effective Date,
Company will reimburse Penn for all historically accrued attorneys fees, expenses, official fees and all other charges accumulated prior to the Effective Date incident to the preparation, filing, prosecution and maintenance of the Patent Rights.
Thereafter, Company will reimburse Penn for all documented attorneys fees, expenses, official fees and all other charges accumulated on or after the Effective Date incident to the preparation, filing, prosecution, and maintenance of the Patent
Rights, within thirty (30) days after Company’s receipt of invoices for such fees, expenses and charges. Penn reserves the right to require the Company to provide a deposit in advance of incurring out of pocket patent expenses estimated by
counsel to exceed [***]. If Company fails to reimburse patent expenses under Paragraph 7.2, provide a requested deposit with respect to a Patent Right, or fails to prepare, prosecute or maintain any Patent Rights that may be in
Penn’s best interest to prepare, prosecute or maintain, then Company shall provide Penn with reasonable prior written notice of such intended abandonment or decline of responsibility. In the event of such failure of Company with respect to such
expenses, deposit or preparation, prosecution or maintenance of any Patent Rights, regardless of notice, Penn will be free at its discretion and expense to either abandon such applications or patents related to such Patent Right or to continue such
preparation, prosecution and/or maintenance activities, and any patent rights associated with such patent action will be automatically excluded from the term “Patent Rights” hereunder, on a patent by patent or country by country
basis, as applicable. 
  

	8.	INFRINGEMENT 

 8.1
Notice. Company and Penn will notify each other promptly of any infringement of the Patent Rights that may come to their attention. Company and Penn will consult each other in a timely manner concerning any appropriate response to the
infringement. 
 8.2 Prosecution of Infringement. Company may prosecute any infringement of the Patent Rights at
Company’s expense, including defending against any counterclaims or cross claims brought by any party against Company or Penn regarding the Patent Rights and defending against any claim that the Patent or Patent Rights are invalid in the course
of any infringement action or in a declaratory judgment action. Penn reserves the right to intervene voluntarily and join Company in any such infringement litigation. If Penn chooses not to intervene voluntarily, but Penn is a necessary party to the
action brought by Company, then Company may join Penn in the infringement litigation. If Company decides not to prosecute any infringement of the Patent Rights, then Penn may elect to prosecute such infringement independently of Company in
Penn’s sole discretion. 
 8.3 Cooperation. In any litigation under this Article 8, either party, at the request and
sole expense of the other party, will cooperate to the fullest extent reasonably possible. This Section 8.3 will not be construed to require either party to undertake any activities, including legal discovery, at the request of any third party,
except as may be required by lawful process of a court of competent jurisdiction. If, however, either party is required to undertake any activity, including legal discovery, as a right of lawful process of a court of competent jurisdiction, then
Company will pay all expenses incurred by Company and by Penn. 

  
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 8.4 Control of Litigation. Company controls any litigation or potential litigation
involving the prosecution of infringement claims regarding the Patent Rights in which Penn is not a party, including the selection of counsel, all with input from Penn. Company must not settle or compromise any such litigation in a manner that
imposes any obligations or restrictions on Penn or grants any rights to the Patent Rights, other than any permitted sublicenses, without Penn’s prior written permission. Penn controls any litigation or potential litigation involving the
prosecution of infringement claims regarding the Patent Rights in which Penn has elected to prosecute the infringement independently of Company or has voluntarily or involuntarily joined Company in the infringement litigation, including the
selection of counsel, all with input from Company. In all instances in which Penn is a party, Penn reserves the right to select its own counsel. If Penn is involuntarily joined as a party, Penn retains the right to select its own counsel, but
Company will be responsible for all litigation expenditures as set forth in Section 8.5. 
 8.5 Recoveries from
Litigation. If Company prosecutes any infringement claims either without Penn as a party or with Penn involuntarily joined as a party, then Company will reimburse Penn for Penn’s litigation expenditures, including any attorneys’ fees,
expenses, official fees and other charges incurred by Penn, even if there are no financial recoveries from the infringement action. Company will reimburse Penn within thirty (30) days after receiving each invoice from Penn. After reimbursing
Penn for its expenditures, Company will use the financial recoveries from such claims, if any, (a) first, to reimburse Company for its litigation expenditures; and (b) second, share between Company [***] and Penn
[***] as to any remainder. If Company prosecutes any infringement claims with Penn joined as a voluntary party, then any financial recoveries from such claims will be (x) first, shared between Company and Penn in proportion with
their respective shares of the aggregate litigation expenditures by Company and Penn; and (y) second, shared [***] by Company and Penn as to any remainder after Company and Penn have fully recovered their aggregate litigation
expenditures. If Penn prosecutes any infringement claims independent of Company, then Penn will prosecute such infringement at Penn’s expense and will retain any financial recoveries in their entirety. 

 

	9.	REPRESENTATIONS; DISCLAIMER OF WARRANTIES 

 9.1 Penn Representations. Penn represents to Company that to the knowledge of the current staff of Penn’s Center for Technology Transfer, without investigation, as of the Effective Date, Penn:
(a) is sole owner of Penn’s Patent Rights; (b) has the right to grant the License to Company; and (c) has not received any written notice of any third party claim for infringement by Penn relating to the Penn Patent Rights.

 9.2 Disclaimer. THE PATENT RIGHTS, LICENSED PRODUCTS AND ANY OTHER TECHNOLOGY LICENSED UNDER THIS AGREEMENT ARE
PROVIDED ON AN “AS IS” BASIS. PENN MAKES NO REPRESENTATIONS (EXCEPT AS SET FORTH IN SECTION 9.1 ABOVE) OR WARRANTIES, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO ANY WARRANTY OF ACCURACY, COMPLETENESS, PERFORMANCE, MERCHANTABILITY,
FITNESS FOR A PARTICULAR PURPOSE, COMMERCIAL UTILITY, NON INFRINGEMENT OR TITLE. 

  
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	10.	LIMITATION OF LIABILITY 

 10.1 Limitation of Liability. PENN WILL NOT BE LIABLE TO COMPANY, ITS AFFILIATES, SUBLICENSEES, SUCCESSORS OR ASSIGNS, OR ANY THIRD PARTY WITH RESPECT TO ANY CLAIM: ARISING FROM COMPANY’S,
AFFILIATES’ OR SUBLICENSEES’ USE OF THE PATENT RIGHTS, LICENSED PRODUCTS OR ANY OTHER TECHNOLOGY LICENSED UNDER THIS AGREEMENT; OR ARISING FROM THE DEVELOPMENT, TESTING, MANUFACTURE, USE OR SALE OF LICENSED PRODUCTS. PENN WILL NOT BE
LIABLE TO COMPANY, ITS AFFILIATES, SUBLICENSEES, SUCCESSORS OR ASSIGNS, OR ANY THIRD PARTY FOR LOST PROFITS, BUSINESS INTERRUPTION, OR INDIRECT, SPECIAL OR CONSEQUENTIAL DAMAGES OF ANY KIND. 

 

	11.	INDEMNIFICATION 


11.1 Indemnification. Company will defend, indemnify, and hold harmless each Indemnified Party from and against any and all
Liabilities with respect to an Indemnification Event. The term “Indemnified Party” means each of Penn and its trustees, officers, faculty, students, employees, contractors, and agents. The term “Liabilities” means
all damages, awards, deficiencies, settlement amounts, defaults, assessments, fines, dues, penalties, costs, fees, liabilities, obligations, taxes, liens, losses, lost profits and expenses (including, but not limited to, court costs, interest and
reasonable fees of attorneys, accountants and other experts) that are incurred by an Indemnified Party or awarded or otherwise required to be paid to third parties by an Indemnified Party. The term “Indemnification Event” means any
Claim against one or more Indemnified Parties arising out of or resulting from: (a) the development, testing, use, manufacture, promotion, sale or other disposition of any Patent Rights, or Licensed Products by Company, its Affiliates,
sublicensees, assignees or vendors or third parties, including, but not limited to, (x) any product liability or other Claim of any kind related to use by a third party of a Licensed Product, (y) any Claim by a third party that the
practice of any of the Patent Rights or the design, composition, manufacture, use, sale or other disposition of any Licensed Product infringes or violates any patent, copyright, trade secret, trademark or other intellectual property right of such
third party, and (z) any Claim by a third party relating to clinical trials or studies for Licensed Products; (b) any material breach of this Agreement by Company or its Affiliates or sublicensees; and (c) the enforcement of this
Article 11 by any Indemnified Party. The term “Claim” means any charges, complaints, actions, suits, proceedings, hearings, investigations, claims or demands. 
 11.2 Reimbursement of Costs. Company will pay directly all Liabilities incurred for defense or negotiation of any Claim or will reimburse Penn for all documented Liabilities incident to the defense
or negotiation of any Claim within thirty (30) days after Company’s receipt of invoices for such fees, expenses and charges. 
 11.3 Control of Litigation. Company controls any litigation or potential litigation involving the defense of any Claim, including the selection of counsel, with input from Penn. Penn reserves the
right to protect its interest in defending against any Claim by selecting its own counsel. If such separate representation is based on Penn’s reasonable determination that Company cannot adequately defend Penn’s interests, or if the
interests of the Indemnified Party and Company with respect to such Claim are sufficiently adverse to prohibit the representation by the same counsel of both parties under applicable law, ethical rules or equitable principals, then any
attorneys’ fees and litigation expenses incurred by Penn for such separate representation will be paid for by Company, pursuant to Sections 11.1 and 11.2. 

  
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 11.4 Other Provisions. Company will not settle or compromise any Claim giving rise to
Liabilities in any manner that imposes any restrictions or obligations on Penn or grants any rights to the Patent Rights or the Licensed Products without Penn’s prior written consent, which shall not be unreasonably withheld. If Company fails
or declines to assume the defense of any Claim within thirty (30) days after notice of the Claim, or fails to reimburse an Indemnified Party for any Liabilities pursuant to Sections 11.1 and 11.2 within the thirty (30) day time period set
forth in Section 11.2, then Penn may assume the defense of such Claim for the account and at the risk of Company, and any Liabilities related to such Claim will be conclusively deemed a liability of Company. The indemnification rights of the
Indemnified Parties under this Article 11 are in addition to all other rights that an Indemnified Party may have at law, in equity or otherwise. 
  

	12.	INSURANCE 

 12.1
Coverages. Company will procure and maintain insurance policies for the following coverages with respect to personal injury, bodily injury and property damage arising out of Company’s performance under this Agreement: (a) during the
Term, comprehensive general liability, including broad form and contractual liability, in a minimum amount of $2,000,000 combined single limit per occurrence and in the aggregate; (b) prior to the commencement of clinical trials involving
Licensed Products, clinical trials coverage in a minimum amount of $3,000,000 combined single limit per occurrence and in the aggregate; and (c) prior to the Sale of the first Licensed Product, product liability coverage, in a minimum amount of
$2,000,000 combined single limit per occurrence and in the aggregate. Penn may review periodically the adequacy of the minimum amounts of insurance for each coverage required by this Section 12.1, and Penn reserves the right to require Company
to adjust the limits accordingly. Any Penn required increase in coverage shall be based upon a reasonable determination by Penn of reasonable and customary levels of coverage, taking into account factors that will include, but not be limited to, the
size of the market, the FDA established safety profile of the product and insurance separately maintained by the manufacturer. The required minimum amounts of insurance do not constitute a limitation on Company’s liability or indemnification
obligations to Penn under this Agreement. 
 12.2 Other Requirements. The policies of insurance required by
Section 12.1 will be issued by an insurance carrier with an A.M. Best rating of “A” or better and will name Penn as an additional insured with respect to Company’s performance under this Agreement. Company will provide Penn with
insurance certificates evidencing the required coverage within thirty (30) days after the Effective Date and the commencement of each policy period and any renewal periods. Each certificate will provide that the insurance carrier will notify
Penn in writing at least thirty (30) days prior to the cancellation or material change in coverage. 
  

	13.	ADDITIONAL PROVISIONS 

 13.1 Independent Contractors. The parties are independent contractors. Nothing contained in this Agreement is intended to create an agency, partnership or joint venture between the parties. At no
time will either party make commitments or incur any charges or expenses for or on behalf of the other party. 

  
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 13.2 No Discrimination. Neither Penn nor Company will discriminate against any
employee or applicant for employment because of race, color, sex, sexual or affectional preference, age, religion, national or ethnic origin, handicap, or veteran status. 
 13.3 Compliance with Laws. Company must comply with all prevailing laws, rules and regulations that apply to its activities or obligations under this Agreement. For example, Company will comply
with applicable United States export laws and regulations. The transfer of certain technical data and commodities may require a license from the applicable agency of the United States government and/or written assurances by Company that Company will
not export data or commodities to certain foreign countries without prior approval of the agency. Penn does not represent that no license is required, or that, if required, the license will issue. 

13.4 Modification, Waiver & Remedies. This Agreement may only be modified by a written amendment that is executed by an
authorized representative of each party. Any waiver must be express and in writing. No waiver by either party of a breach by the other party will constitute a waiver of any different or succeeding breach. Unless otherwise specified, all remedies are
cumulative. 
 13.5 Assignment & Hypothecation. This Agreement is binding upon the parties and their respective
heirs, successors, assigns, and personal representatives. Company may not assign this Agreement or any part of it, either directly or by merger or operation of law, without the prior written consent of Penn, except in connection with a merger or the
sale, or other transfer of all or substantially all of its assets or all of its business or the business unit holding its cancer vaccine products and technology to a pharmaceutical or vaccine company with a market capitalization or annual revenues
of at least $100,000,000, provided that (a) at least ten (10) days before the proposed transaction, Company gives Penn written notice and such background information as may be reasonably requested by Penn; (b) the assignee agrees in
writing to be legally bound by this Agreement and to deliver to Penn an updated Business Plan within forty five (45) days after the closing of the proposed transaction; and (c) Company provides Penn with a copy of assignee’s
undertaking. Any permitted assignment will not relieve Company of responsibility for performance of any obligation of Company that has accrued at the time of the assignment. Company will not grant a security interest in the License or this Agreement
during the Term. Any prohibited assignment or security interest will be null and void. 
 13.6 Notices. Any notice or
other required communication (each, a “Notice”) must be in writing, addressed to the party’s respective Notice Address listed on the signature page, and delivered: (a) personally; (b) by certified mail, postage
prepaid, return receipt requested; (c) by recognized overnight courier service, charges prepaid; or (d) by facsimile. A Notice will be deemed received: if delivered personally, on the date of delivery; if mailed, five (5) days after
deposit in the United States mail; if sent via courier, one (1) business day after deposit with the courier service; or if sent via facsimile, upon receipt of confirmation of transmission provided that a confirming copy of such Notice is sent
by certified mail, postage prepaid, return receipt requested. 

  
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 13.7 Severability & Reformation. If any provision of this Agreement is held
to be invalid or unenforceable by a court of competent jurisdiction, then the remaining provisions of this Agreement will remain in full force and effect. Such invalid or unenforceable provision will be automatically revised to be a valid or
enforceable provision that comes as close as permitted by law to the parties’ original intent. 
 13.8
Headings & Counterparts. The headings of the articles and sections included in this Agreement are inserted for convenience only and are not intended to affect the meaning or interpretation of this Agreement. This Agreement may be
executed in several counterparts, all of which taken together will constitute the same instrument. 
 13.9 Governing Law.
This Agreement will be governed in accordance with the laws of the Commonwealth of Pennsylvania, without giving effect to the conflict of law provisions of any jurisdiction. 
 13.10 Dispute Resolution. If a dispute arises between the parties concerning any right or duty under this Agreement, then the parties will confer, as soon as practicable, in an attempt to resolve
the dispute. If the parties are unable to resolve the dispute amicably, then the parties will submit to the exclusive jurisdiction of, and venue in, the state and Federal courts located in the Eastern District of Pennsylvania if an action is brought
by Company and Delaware if any action is brought by Penn with respect to all disputes arising under this Agreement. 
 13.11
Integration. This Agreement with its Exhibits, and the Confidentiality Agreement, contain the entire agreement between the parties with respect to the Patent Rights and the License and supersede all other oral or written representations,
statements, or agreements with respect to such subject matter. 
 Each party has caused this Agreement to be executed by its
duly authorized representative. 
  

									
	 THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
	 		 	IMMUNOCELLULAR THERAPEUTICS, LTD
					
	By:	 	 /s/ Michael J. Cleare, PHD
	 		 	By:	 	/s/ Manish Singh, PhD
		 	 Name: Michael J. Cleare, PHD
	 		 		 	Name: Manish Singh, PhD
		 	 Title: Executive Director, Center for Technology Transfer
	 		 		 	Title: CEO
					
	Address:	 	 Center for Technology Transfer

University of Pennsylvania

3160 Chestnut Street, Suite 200

Philadelphia, PA 19104-6283

Attention: Executive Director
	 		 	Address:	 	 21900 Burbank Blvd.
 3rd Floor
 Woodland Hills, CA 91367
 Attention: CEO

				
	 Required copy to:
	 		 		 	
		 	 University of Pennsylvania

Office of General Counsel

133 South 36th Street, Suite 300

Philadelphia, PA 19104-3246

Attention: General Counsel
	 		 		 	


  
 15 









 EXHIBIT INDEX 

 

			
		
	Exhibit A	  	Patent Applications in Patent Rights
		
	Exhibit B	  	Minimum Contents of Business Plan
		
	Exhibit C	  	Format of Royalty Report
		
	Exhibit D	  	Confidentiality Agreement


  
 16 









 Exhibit A 

Patent Applications in Patent Rights 
  

													
	 W5470
	  	 System and Method of Preparing and Storing
Activated Mature
Dendritic Cells

	 Serial No
	  	 Patent No
	  	App Type	  	File Date	 	  	Country	  	Issue Date
	 61/313,984
	  		  	Provisional	  	 	3/15/2010	  	  	US	  	
	 PCT/US11/28487
	  		  	PCT	  	 	3/15/2011	  	  	US	  	


  
 17 









 Exhibit B 

Minimum Contents of Business Plan 
  

	 	•	 	 Date of Business Plan and reporting period covered 


  

	 	•	 	 Identification and nature of each active contractual relationship between Company, its Affiliates and sublicensees 



 

	 	•	 	 Current status of DC vaccine program 


  

	 	•	 	 Projected timelines for completing Licensed Product development and commercial launch 



 

	 	•	 	 Projected timeline for securing sublicensees 


  

	 	•	 	 Significant changes made to the Business Plan since the previous Development Plan and the reasons for the changes 



  
 18 









 Exhibit C 

Form of Royalty Report 
 



 
  

  
 19 









 Exhibit D 

Form of Confidentiality Agreement 
 UNIVERSITY of PENNSYLVANIA 
 Confidential Disclosure Agreement 
 Signature Page 

 

					
	 COMPANY CONTACT INFORMATION

 

	 Company full legal name and notice address:

IMMUNOCELLULAR THERAPEUTICS LTD

21900 BURBANK BOULEVARD, 3RD
FLOOR
 WOODLAND HILLS, CA 91367

 
	  	 Company primary phone number:
 818-992-2907
  

	  	 Company primary fax number:
 818-992-2908
  

			
	 Company contact name:
 Manish Singh, PhD, MBA
	  	 Contact title:
 President and CEO
	  	 Contact phone number:
 [***]

	
	 PENN CONTACT INFORMATION

 

	 Penn notice address:

University of Pennsylvania
 Center for Technology Transfer
 3160 Chestnut Street, Suite 200

Philadelphia, PA 19104-6283
 Attention: Executive Director
	  	 Penn primary phone number:
 215-898-9591
  
 Penn primary fax number:
 215-898-9519

	  
			
	 Penn Investigator name:
 Brian Czerniecki, MD, PhD
	  	 Penn department:
 Surgery
	  	

  

			
	 SUBJECT MATTER

 

	 Penn Docket and application numbers and titles:

Application nos. 61/313,984 and PCT/US11/28487

Reference only: W5470 entitled System and Method of
 Preparing and Storing Activated Mature Dendritic Cells
	  	 Investigator research area:
 Cell-based Immunotherapy of Cancer


  

			
	 PURPOSE & EFFECTIVE DATE

 

	 Limited Purpose:
 Company’s exercise of its rights and performance of its obligations under that certain patent license agreement (“License Agreement”) by and between the parties of even date herewith
related to the patents and patent applications in Penn’s Dockets listed above.
	  	 Effective Date:
 3/19/12


  

							
	SIGNATURES  

	This Agreement includes this Signature Page and all of the attached Terms and Conditions. By signing below, Company and Penn agree to all of the provisions.
 

	COMPANY 	 	THE TRUSTEES OF THE UNIVERSITY OF
PENNSYLVANIA
				
	By:	 	 	 	By:	 	 
		 	         (please sign)
	 		 	             (please sign)

	Name: 	 	 	 	Name: 	 	 
		 	         (please print)
	 		 	             (please print)

	Title:	 	 	 	Title:	 	 
		 	         (please print)
	 		 	             (please print)

	Date:	 	 ______________________, 2012
	 	Date:	 	 ______________________, 2012



  
 20 









 Confidential Disclosure Agreement 

Terms and Conditions 

 


 1. Purpose. Penn desires to protect its Confidential Information, which may
be disclosed to Company by Penn. 
 2. Definition. The term “Confidential Information” means
all information, data or know-how that is contained in or related to the Patent Rights (as defined in the License Agreement) and the Penn Dockets relating thereto and/or the general area of research in the Investigator’s laboratory identified
in the Signature Page. Confidential Information does not include information, data or know-how that: (a) becomes part of the public domain through no improper action of the Company; (b) was in the possession of the Company at the time of
disclosure; (c) is received by the Company from a third party and is not subject to an obligation of confidentiality owed to such third party; or (d) can be shown by documentation to have been independently developed by Company by
individuals who have not had access to Confidential Information. Failure to mark any Confidential Information as confidential or proprietary will not affect its status as Confidential Information under this Agreement. 

3. Non-Use & Non-Disclosure. Company will not use any Confidential Information for any purpose, other than for
the Limited Purpose identified on the Signature Page. No licenses or other rights are granted. Company will not use Confidential Information for experimental research planning or experimental activity. Company will not disclose any Confidential
Information to third parties or employees, other than on a need to know basis to those employees and consultants who are bound to obligations of non-use and non-disclosure at least as restrictive as those set forth in this Agreement. Company will
take all reasonable measures to protect the secrecy of, and avoid the unauthorized disclosure or use of, Confidential Information. Such measures will include the highest degree of care that Company utilizes to protect Company’s own confidential
information of a similar nature. Company will promptly notify Penn in writing of any misuse or misappropriation of any Confidential Information that may come to Company’s attention. In the event that Company is required by judicial or
administrative process to disclose Confidential Information, Company will promptly notify Penn and allow Penn a reasonable time to oppose such process.



 4. Term. This Agreement applies to Confidential Information that is
disclosed to Company from the Effective Date. Company’s obligations as to any item of Confidential Information will expire upon the later of: (i) five (5) years after the initial disclosure of such item to Company; or
(ii) termination of the License Agreement. Company’s obligations under this Agreement will survive the expiration or termination of any other contract or negotiation between the parties. Upon the written request of Penn, Company will
return to Penn all Confidential Information received from Penn, except that Company may maintain a single copy of any written Confidential Information for Company’s records. 

5. Use of Penn’s Name. Company will not use Penn’s name or trademarks or the name of any Penn employee in any
manner without Penn’s prior written consent. 
 6. Disclaimer. All Confidential Information is provided on
an “As Is” basis, without express or implied warranties of any kind. 
 7. Miscellaneous. Any
notice must be in writing and sent to the address of the party listed on the Signature Page. This Agreement may only be modified by a written amendment that is executed by an authorized representative of each party. Any waiver must be
express and in writing. No waiver by either party of a breach by the other party will constitute a waiver of any different or succeeding breach. This Agreement will be governed by and construed in accordance with the laws of the
Commonwealth of Pennsylvania without regard to conflicts of law principles of any jurisdiction. This Agreement contains the entire agreement between the parties with respect to subject matter of this Agreement and supersedes all other oral or
written representations, statements, or agreements with respect to such subject matter. This Agreement is binding upon the parties and their respective heirs, successors, assigns, and personal representatives. Neither party may assign this Agreement
without the prior written consent of the other party. 

 


  
 21