United States Chemical Safety September 2011 Environmental Protection and Pollution Prevention Agency (7510P)



# Alkyl Imidazolines Summary Document: Registration Review : Initial DocketDocket Number: EPA

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### TABLE OF CONTENTS
Alkyl Imidazolines Registration Review Team

................................ ................................ ... 4 I. Preliminary Work Plan

................................ ................................ ................................ ..... 5 II. Fact Sheet

................................ ................................ ................................ ...................... 12 III. Summary of Anticipated Data Requirements

................................ .............................. 15 IV. Appendix A

................................ ................................ ................................ .................. 16

________________________________________ Please Note This Preliminary Work Plan and Fact Sheet summarize the Environmental Protection Agency's current position based on the following documents:
1. Summary of Product Chemistry, Environmental Fate, and Ecotoxicity Data for the 1

- (2

- Hydroxyet hyl)

- 2

- alkyl

- 2

- imidazoline (as in fatty acids of tall oil) Registration Review Decision Document

. August 11, 2011
2. Alkyl Imidazoline: Human Health Risk Assessment Scoping Document in Support of Registration Review

. August 9, 2011

Additional supporting documents for the Alkyl Imidazolines Case may be found in the registration review docket EPA

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4 of 17 Alkyl Imidazolines Registration Review Team

Human Health & Environmental Effects Timothy Dole Srinivas Gowda Risk Management Eliza Blair Lance Wormell
Office of General Counsel Philip RossDocket Number: EPA

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5 of 17 I. Preliminary Work Plan

-- Alkyl Imidazolines
Introduction : The Food Quality Protection Act (FQPA) of 1996 mandated a registration review program

. All pesticides distributed or sold in the United States generally must be registered by the U.S. Environmental Protection Agency (USEPA, EPA, or the Agency) based on sci entific data showing that they will not cause unreasonable risks to human health or the environment when used as directed on product labeling

. The registration review program is intended to make sure that, as the ability to assess risk evolves and as polic ies and practices change, all registered pesticides continue to meet the statutory standard of no unreasonable adverse effects to human health or the environment

. Changes in science, public policy, and pesticide use practices will occur over time

. Through the registration review program, the Agency periodically reevaluates pesticides to make sure that as change occurs, products in the marketplace can be used safely

. Information on this program is provided at http://www.epa.gov/oppsrrd1/registration_review/

. The Agency is implementing the registration review program pursuant to Section 3(g) of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and will review each registered pesticide every 15 years to determine whether it continues to meet the FIFRA standard for registration

. The Agency will consider benefits information and data as required by FIFRA

. The public phase of registration review begins when the initial docket is opened for each case

. The docket is the Agency’s opportunity to state what it knows about the pesticide and what additional risk analyses and data or information it believes are needed to make a registration review decision

. After reviewing and responding to comment s and data received in the docket during this initial comment period, the Agency will develop and commit to a final work plan and schedule for the Alkyl Imidazolines C ase

. Alkyl imidazoline is a microbiocide/microbiostat registered for use in fuel and oil storage tank bottom water. Products containing alkyl imidazoline are registered for use to prevent the growth of slime

- forming bacteria and fungi which might interfere with the use and quality of oils and fuels in storage tanks. There is one soluble concentrate liquid product, with 25% active ingredient. The p roduct is loaded and applied through a closed delivery system that has a proportioning pump or siphon type feeder to meter the pesticide product directly from the product container into the fuel oil as it is pumped into stor age tanks. The p roduct is not register ed for homeowner use or f or use in or around residences. There are two active ingredients in the Alkyl imidazo lines Case 3010; however, one of these active ingredients, 2

- heptadecentyl

- 2

- imidazoline (PC Code: 046612; CAS No.: 30968

- 43

- 5), does not have a ny registered pr oducts , is not being supported , and is not be ing addressed in this registration review. 1

- (2

- Hy droxyethyl)

- 2

- alkyl

- 2

- imidazoline (as in fatty acids of tall oil), hereafter referred to as alkyl imidazoline, is the only active ingredient in the case with any registered products. The first product containing a lkyl i midazoline (PC Code 046609 ) as an active ingredient was registered in the United States in 1970

. Currently , there is only one product containing alkyl imidazoline that is registered with EPA. The Agency completed a Reregistration Eligibility Decision (RED) for alkyl imidazoline in 1995

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6 of 17 Documents associated with the registration review of Alkyl imidazolines can be viewed at www.regulations.gov in docket EPA

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. Below is a summary of the issues relevant to th is registration review case. Anticipated Risk Assessment and Data Needs : The Agency anticipates the need to conduct a comprehensive ecological risk assessment, including an endangered species risk assessment, for all uses of alkyl imidazoline, and anticipates that additional data will be needed

. However, t he Agency does not anticipate the need to conduct a human health risk assessment for alkyl imidazoline

. Ecological Risk :

**•** No recent ecological risk assessment has been performed for alkyl imidazoline

.

**•** The Agency has not conducted a risk assessment that supports a complete endangered species determination for alkyl imidazoline

. The ecological risk assessment planned during registration review will allow the Agency to determine whether alk yl imidazoline ’s use has 'no effect' or 'may affect' federally listed threatened or endangered species (listed species) or their designated critical habitats. When an assessment concludes that a pesticide’s use 'may affect' a listed species or its designated critical habitat, the Agency will consult with the U.S. Fish and Wildlife Service and/or National Marine Fisheries Services (the Services), as appropriate.

**•** The Agency anticipates the need for the following additional ecological data for use in the registration review of alkyl imidazoline , including an endangered species risk assessment

. These data were not re quired at the time of registration and are necessary to characterize the risk to aquatic organisms from the disposal of alkyl imidazoline

- treated water residue down conventional drains.

o (GLN 850. 2100 ) Acute Avian Oral Toxicity;
o (GLN 850. 1010 ) Acute Freshwater Invertebrates Toxicity;
o (GLN 850. 1075 ) Acute Freshwater Fish Toxicity; and
o (GLN 850.5400) algal toxicity (Tier II) using freshwater green alga, Selenastrum capricornutum

.

**•** The Agency anticipates the need to require the following additional environmental fate data for use in the registration review of alkyl imidazoline

. These data are necessary to complete a full down

- the

- drain environmental fate assessment.

o (GLN 835.2120) Hydrolysis;
o (GLN 835. 2240) Photodegradation in water
o (GLN 850.6800) Modified Activated Sludge Respiration Inhibition 1

1 Based on the results of any required Activated Sludge Respiration Inhibition Test (ASRI), registrants may be able to request that EPA waive the requirements for additional biodegradation tests. If the ASRI test EC 50 is less than or equal to 20 mg/L, registrants would need to perform one of 835.3220, 835.3240, or 835.3280. If the ASRI test EC 50 is greater than 20 mg/L, registrants would need to perform either (i)Docket Number: EPA

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7 of 17 o (GLN 835.3110) Ready biodegrad ability
o (GLN 835.3220) Porous Pot Test
o (GLN 835.3240) Simulation Test

– Aerobic Sewage Treatment: A. Activated Sludge Units
o (GLN 835.3280) Simulation Tests to Assess the Biodegradability of Chemicals Discharged to Wastewater.

**•** F or more information , please refer to Summary of Product Chemistry, Environmental Fate, and Ecotoxicity Data for the 1

- (2

- Hydroxyethyl)

- 2

- alkyl

- 2

- imidazoline (as in fatty acids of tall oil) Reg istration Review Decision Document , located in the docket

. Human Health Risk :

**•** The most recent human health risk assessment for alkyl imidazoline was performed in support of the 1995 RED. The Agency does not anticipate the need for additional human health data at this time and does not anticipate that an updated risk assessment will be needed due to the limited potential for exposure

. F or more information , please refer to Alkyl Imidazoline: Human Health Risk Assessment Scoping Document in Support of Registration Review , located in the docket

. Product Chemistr y :

**•** The Agency does not anticipate the need to require addi tional product chemistry data for this registration review case at this time.

**•** F or more information , please refer to Summary of Product Chemistry, Environmental Fate, and Ecotoxicity Data for the 1

- (2

- Hydroxyethyl)

- 2

- alkyl

- 2

- imidazo line (as in fatty acids of tall oil) Registration Review Decision Document , located in the docket

. Endocrine Disruptor Screening Program As required by FIFRA and FFDCA, EPA reviews numerous studies to assess potential adverse outcomes from exposure to c hemicals

. Collectively, these studies include acute, subchronic and chronic toxicity, including assessments of carcinogenicity, neurotoxicity, developmental, reproductive, and general or systemic toxicity. These studies include endpoints which may be susceptible to endocrine influence, including effects on endocrine t arget organ histopathology, organ weights, estrus cyclicity, sexual maturation, fertility, pregnancy rates, reproductive loss, and sex ratios in offspring

. For ecological hazard assessments, EPA evaluates acute tests and chronic studies that assess growth, developmental and reproductive effects in different taxonomic groups

. As part of its reregistration decision , EPA reviewed these data and selected the most sensitive endpoints for relevant risk assessment scenarios from the existing hazard

835.3110 or (ii) one of 835.3220, 835.3240, or 835.3280. If the antimicrobial reaches pass levels for 835.3110 (i.e., 70% removal of dissolved organic carbon (DOC) and 60% removal of theoretical oxygen demand (ThOD) or theoretical carbon dioxide (ThCO 2 ) production for respirometric methods) in a 10

- day window within the 28

- day period of the test, registrants would be able to request that EPA waive the requirements for additional biodegradation tests. If the antimicrobial does not pass 835.3110, the registrants would need to perform one of 835.3220, 835.3240, or 835.3280.Docket Number: EPA

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8 of 17 database

. Howev er, as required by FFDCA section 408(p), alkyl imidazoline is subject to the endocrine screening part of the Endocrine Disruptor Screening Program (EDSP). EPA has developed the EDSP to determine whether certain substances (inc luding pesticide active and other ingredients) may have an effect in humans or wildlife similar to an effect produced by a “naturally occurring estrogen, or other such endocrine effects as the Administrator may designate.” The EDSP employs a two

- tiered app roach to making the statutorily required determinations. Tier 1 consists of a battery of 11 screening assays to identify the potential of a chemical substance to interact with the estrogen, androgen, or thyroid (E, A, or T) hormonal systems

. Chemicals that go through Tier 1 screening and are found to have the potential to interact with E, A, or T hormonal systems will proceed to the next stage of the EDSP where EPA will determine which, if any, of the Tier 2 tests are necessary based on the available data. Tier 2 testing is designed to identify any adverse endocrine

- related effects caused by the substance, and establish a dose

- response relationship between the dose and the E, A, or T effect. Under FFDCA section 408(p), the Agency must screen all pesticide chemical s. Between October 2009 and February 2010, EPA issued test orders/data call

- ins for the first group of 67 chemicals, which contains 58 pesticide active ingredients and 9 inert ingredients. alkyl imidazoline is not
am ong the group of 58 pesticide active ingredients on the initial list to be screened under the EDSP. Accordingly, as part of registration review, EPA will issue future EDSP orders/data call

ins, requiring the submission of EDSP screening assays for alkyl im idazoline

. For further information on the status of the EDSP, the policies and procedures, the list of 67 chemicals, future lists, the test guidelines and the Tier 1 screening battery, please visit our website: http://www.epa. gov/endo/

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9 of 17 Timeline EPA has created the following estimated timeline for the completion of the a lkyl imidazolines registration review: Anticipated Schedule Activities Estimated Month/Year Phase 1: Opening the docket Open Public Comment Period for Docket September 2011 Close Public Comment Period for Docket November 2011 Phase 2: Case Development Develop Final Work Plan (FWP) March 2012 Issue DCI March 2013 Data Submission March 2014 Open Public Comment Period for Preliminary Risk Assessments September 2015 Close Public Comment Period for Preliminary Risk Assessments Nov ember 2015 Phase 3: Registration Review Decision Open Public Comment Period for Proposed Reg. Review Decision March 2016 Close Public Comment Period for Proposed Reg. Review Decision April 2016 Final Decision and Begin Post

- Decision Follow

- up 2016 Total (years) 5

Guidance for Commenters : The public is invited to comment on EPA’s P reliminary W ork P lan and rationale

. The Agency will carefully consider all comments as well as any additional information or data provided in a timely manner prior to issuing a final work plan for the a lkyl imidazolines registration review
case.
Trade Irrit ants : Through the registration review process, the Agency intends to solicit information on trade irritants and, to the extent feasible, take steps toward facilitating irritant resolution

. Growers and other stakeholders are asked to comment on any trade irritant issues resulting from lack of Maximum Residue Limits (MRLs) or disparities between U.S. tolerances and MRLs in key export markets, providing as much specificity as possible regarding the nature of the concern. Water Quality : Alkyl imidazoline is not identified as a cause of impairment for any water bodies listed as impaired under section 303(d) of the Clean Water Act, based on information provided at http://iaspub.epa.gov/tmdl_waters10/attains_nation_cy.cause_detail_303d?p_cause_group_id=88 5. In a ddition, no Total Maximum Daily Loads (TMDL) have been developed for alkyl imidazoline , based on information provided atDocket Number: EPA

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10 of 17 http://iaspub.epa.gov/tmdl_waters10/attains_nation.tmdl_pollutant_detail?p_pollutant_group_id =885& p_pollutant_group_name=PESTICIDES. More information on impaired water bodies and TMDLs can be found at http://www.epa.gov/owow/tmdl/

. The Agency invites submission of water quality data for this pesticide

. To the extent possible, data should conform to the quality standards in Appendix A of the OPP Standard Operating Procedure: Inclusion of Impaired Water Body and Other Water Quality Data in OPP’s Registration Review Risk Assessment and Management Process (see: http://www.epa.gov/oppsrrd1/registration_review/water_quality_sop.htm ), in order to ensure the data can be used quantitatively or qualitatively in pesticide risk assessmen ts.
Environmental Justice : EPA seeks to achieve environmental justice, the fair treatment and meaningful involvement of all people, regardless of race, color, national origin, or income, in the development, implementation, and enforcement of environmental laws, regulations, and policies. To help address potential environmental justice issues, the Agency seeks information on any groups or segments of the population who, as a result of their location, cultural practices, or other factors, may have atypical, u nusually high exposure to alkyl imidazoline compare d to the general population. Please comment if you are aware of any sub

- populations that may have atypical, unusually high exposure compared to the general population.
Structure Activity Relationships : EPA must rely upon information of appropriate quality and reliability for each decision made by the Agency

. In the Office of Pesticide Programs (OPP), the evaluation process for a pesticide chemical traditionally begins with the applicant’s submission of a set of studies conducted with the specific pesticide chemical of interest

. The use of the results of such testing (measured data) is a logical, scientifically rigorous process that identifies the physical, chemical, and environm ental fate properties of the pesticide, as well as the dose and endpoints at which an adverse effect can occur in various animal species. Today, there is significant interest in alternative techniques, i.e., techniques other than data generation that coul d significantly inform the Agency’s decision

- making process

. Recently, OPP has made increasing use of structure activity relationship (SAR) as part of its regulatory decision

- making process

. In the SAR process, a chemical's molecular structure is compared to that of other chemicals for which data are available

. These structural similarities are then used to make predictive judgments about a chemical’s physical, chemical, and biological properties

. Thus, the chemical’s physical, chemical, and biological prop erties are a function of (or directly related to) the chemical’s molecular structure

. Quantitative SAR is referred to as QSAR

. To develop a QSAR, a selected set of measured data on a single physical, chemical, or biological property is used to derive a mod el (an equation) to predict the value of that property

. Since SAR assessments and QSAR modeling are another set of tools that are available to Agency scientists, OPP has begun a process shift that envisions shifting from the current study

- by

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11 of 17 Part 161 requirements

. All relevant information would be considered as part of a weight

- of

- the

evidence evaluation

. At this time, EPA believes that for certain endpoints, especially physical/chemical and fate properties, that SAR and QSAR might be effectively utilized to fulfill these data requirements for many antimicrobia l pesticide chemicals

. When considering biological properties, at this time, EPA believes that SAR and QSAR can be most effectively utilized in the evaluation of chemicals that exhibit lower toxicity for human health and/or ecotoxicity parameters

. This is appropriate because the risk assessment for lower toxicity chemicals can be stream

- lined, i.e., a screening

- level assessment procedure rather than multiple tiers of assessments with progressively more data requirements.

If stakeholders believe that submiss ion of predicted data can fulfill one of the data needs for the alkyl i midazolines c ase , then the Agency invites submission of this information

. The submitter would be expected to supply a rationale describing the utility of the information and provide documentation on the scientific validity of the information

. The determination that the predicted data fulfills the data requirement would be at the sole discretion of the Agency

. Pre

- submission consultation with the Agency is e ncouraged.

Additional Information : Stakeholders are also specifically asked to provide available information and data that will assist the Agency in refining its risk assessments , including any species

- specific ecological effects determinations

. The Agency is interested in receiving the following information:

1. Confirmation on the following label information:
a. Sites of application b. Formulations
c. Application methods and equipment d. Maximum application rates
e. Frequency of application, application intervals and maximu m number of applications f. Geographic limitations on use 2. Use or potential use distribution 3. Use history 4. Usage/use information for non

- agricultural uses (e.g., materials preservation) 5. Typical application interval 6. State or local use restrictions 7. Ecological inci dents (non

- target plant damage and avian, fish, reptilian, amphibian and mammalian mortalities) not already reported to the Agency 8. Monitoring data Next Steps :
After the 60

- day comment period closes in November 2011 , the Agency will review and respond to any comments received in a timely manner, and then issue a Final Work Plan for the alkyl i midazolines c ase

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12 of 17 II. Fact Sheet Background Information :

**•** Active Ingredient: Alkyl Im idazoline

**•** C ase number: 3010

**•** PC Code: 046609

**•** CAS number : 61791

- 39

- 7

**•** Technical registrants: Nalco Energy Services

**•** First approved for use in a registered product: 1970

**•** Antimicrobials Division Chemical Review Manager (CRM): Eliza Blair , blair.eliza@epa.gov

**•** Antimicrobials Division Product Manager (PM): Marshall Swindell, swindell.marshall@epa.gov

**•** Chemical Structure:

Use & Usage Information :

**•** Alkyl imidazoline is a microbiocide/microbiostat registered for use in fuel and oil storage tank bottom water. The p roduct containing alkyl imidazoline is registered for use to prevent the growth of slime

- forming bacteria and fungi which might interfere with the use and quality of oils and fuels in storage tanks. There i s one soluble concentrate liquid product, with 25% active ingredient. The p roduct is loaded and applied through a closed delivery system that has a proportioning pump or siphon type feeder to meter the pesticide product directly from the product container into the fuel oil as it is pumped into storage tanks. The p roduct is not registered for homeowner use or for use in or around residences. Recent/Pending Regulatory Actions :

**•** No recent or pending regulatory actions exist for alkyl imidazoline. Ecological Risk Assessment Status :
Please refer to Summary of Product Chemistry, Environmental Fate, and Ecotoxicity Data for the 1

- (2

- Hydroxyethyl)

- 2

- alkyl

- 2

- imidazoline (as in fatty acids of tall oil) Registration Review Decision Document , located in the docket, for a detailed dis cussion of the ecological risk assessments.

**•** The Agency has not conducted an ecological and environmental fate assessment for alkyl imidazoline. The Agency needs to conduct environmental fate and ecological risk
assess ments for alkyl imidazoline’s use as a fuel oil treatment

. For use in the planned ecological risk assessment, including an endangered species assessment, th e Agency anticipates needing ecological effects data to characterize alkyl imidazoline’s toxicity to birds, fish, and aquatic invertebrates

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13 of 17 **•** The Agency has not conducted a risk assessment for alkyl imidazoline that supports a complete endangered species effects determination. The ecological risk assessment planned during registration review will allow t he Agency to determine whether alkyl imidazoline use has “no effect” or “may affect” federally listed threatened or endangered species (listed species) or their designated critical habitats. When an assessment concludes that a pesticide’s use “may affect” a listed species or its designated critical habitat, the Agency will consult with the U.S. Fish and Wildlife Service and/or National Marine Fisheries Services (the Services), as appropriate.
Human Health Risk Assessment Status :
Please refer to Alkyl Imidazoline: Human Health Risk Assessment Scoping Document in Support of Registration Review , located in the docket, for a detailed discussion of the human health risk assessment.
Hazard Characterization:

**•** Alkyl imidazoline's sole registered use as a fuel oil preservative, and the fact that it is required by the label to be mixed via closed system at industrial sites, make the potential for human exposure small

. D ietary (Food and Water ):

**•** Dietary and drinking water exposures to alkyl imidazoline have not been assessed and are not anticipated because of the use pattern which is limited to fuel storage tanks. Because alkyl imidazolin e has an octanol water coefficient of 28,500 , it will partition to the oil phase of the treated fuel and it will remain in the oil phase if the treated fuel contaminates drinking water. It is likely therefore, the oil itself will contaminate the drinking water and cause odor and taste problems long before alkyl imidazoline will reach significant levels.
Residential:

**•** Residential exposures to alkyl imidazoline have not been assessed and are not anticipated because it is regis tered for use only in industrial fuel storage facilities. Aggregate:

**•** The Agency has not conducted an aggregate risk assessment for alkyl imidazoline.

**•** In examining aggregate exposure, EPA takes into account the available and reliable information concerning exposures to pesticide residues in food and drinking water, as well as non

- occupational pesticide exposures. An aggregate risk assessment ha s not been deemed necessary for alkyl imidazoline because of the limited use patterns and limited potential for exposure.Docket Number: EPA

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14 of 17 Occupational:

**•** Occupational ha ndler exposures were assessed in the 1995 RED for the mixing and loading for the fuel preservation use. The MOEs were calculated for “total exposures” based on the addition of the dermal and inhalation exposures and were assessed using the oral endpoint of 15 mg/kg/day along with a dermal absorption factor of 100 percent and a daily fuel treatment volume of 10,000 gallons. All of the MOEs were above the target MOE of 100 and , therefore, were not considered to be of concern.

**•** No occupational exposure asses sments are needed if the current label requirement for closed system use is maintained.
Cumulative:

**•** Unlike other pesticides for which EPA has followed a cumulative risk approach based on a common mechanism of toxicity, EPA has not made a common mechanism of toxicity finding as to alkyl imidazoline and any other substances and alkyl imidazoline does not appear to produce a toxic metabolite produced by other substances. Fo r the purposes of this registration review action, therefore, EPA has not assumed that alkyl imidazoline has a common mechanism of toxicity wit h other substances

. For information regarding EPA ’ s efforts to determine which chemicals have a common mechanism of toxicity and to evaluate the cumulative effects of such chemicals, see the policy statements released by EPA ’ s Office of Pesticide Programs concerning common mechanism determinations and procedures for cumulating effects from substances found to have a common mechanism on EPA ’ s website at http://www.epa.gov/pesticides/cumulative/.

Incidents: Ecological:

**•** No alkyl imidazoline ecological incidents have been reported in the OPP incident database.
Human Health:

**•** No alkyl imidazoline human poisoning incidents have been reported in the OPP incident database.

Tolerances and International Harmonization :

**•** No tolerances or exemptions from tolerances have been established for alkyl imidazoline. Alkyl imidazoline is not approved for use as an indirect f ood additive.
Data Call

- In Status :

**•** No recent data call

- in has been issued for alkyl imidazoline.

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15 of 17 Registered products, including EPA r egistration n umbers are provided in Table 1 below

. For future reference, during registration review a list of product registration numbers will be included in the docket. Product registration labels may be obtained from the Pesticide Product Label System (PPLS) website at: http://oaspub.epa.gov/pestlabl/ppls.home

. Table 1

. Registered Products

–

Registration No. Registration Name Company Name Formulation Type % of Active Ingredient

68708

- 3 NALCO 2210 Fuel Oil Treatment Nalco Energy Services, L.P. Ready

- to

- use Solution 25

III. Summary of Anticipated Data Requirements

– Alkyl Imidazolines

The table below summarizes anticipated data needs for the Alkyl Imidazolines Case in Section I of this document (Preliminary Work Plan), Summary of Product Chemistry, Environmental Fate, and Ecotoxicity Data for the 1

- (2

- Hydroxyethyl)

- 2

- alkyl

- 2

- imidazoline (as in fatty acids of tal l oil) Registration Review Decision Document , and Alkyl Imidazoline: Human Health Risk Assessment Scoping Document in Support of Registration Review

. Table 2

. Summary of Anticipated Data Requirements

–

Guideline Number Anticipated Data Requirement Test Material Est imated Timeframe (Measured in months from DCI Receipt)
835.2120 Hydrolysis TGAI 12
835.2240 Photodegradation in Water TGAI 12

850.6800 Modified Activated Sludge Respiration Inhibition TGAI 12

835.3110 Ready biodegradability TGAI 12
835.3220 Porous Pot Test TGAI 12

835.3240 Simulation Test

– Aerobic Sewage Treatment: A. Activated Sludge Units TGAI 12

835.3280 Simulation Tests to Assess the Biodegradability of Chemicals Discharged to Wastewater TGAI 12

850.2100 Acute Avian Oral Toxicity TGAI 12
850.1010 Acute Freshwater Invertebrates Toxicity TGAI 12
850.1075 Acute Freshwater Fish Toxicity TGAI 12
850.5400 Algal Toxicity using freshwater green TGAI 12Docket Number: EPA

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16 of 17 alga, Selenastrum capricornutumDocket Number: EPA

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17 of 17 IV. Appendix A : Use Patterns

– Alkyl imidazolines

Use Site Formulation/ EPA Reg.
no. Method of Application Application Rate/ No. of applications Use Limitations

Hydrocarbon fuel preservative 68708

- 3 Metering pump For use with closed delivery systems only. Use 40 to 80 ppm of 2210 Fuel Oil Treatment based on fuel oil. Feed 2210 Fuel Oil Treatment by means of proportioning pump or siphon type feeder directly from drum or other container to the fuel oil as it is pumped into storage tanks. Not for individual use
or use near residences.