PROPOSAL FOR PRIORITY SETTING 

FOR EXISTING SUBSTANCES ON THE 

DOMESTIC SUBSTANCES LIST UNDER THE 

CANADIAN ENVIRONMENTAL PROTECTION ACT, 1999 

GREATEST POTENTIAL FOR HUMAN EXPOSURE 

Health Canada 

2003
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

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Table of Contents 

1. Introduction......................................................................................................................... 1 

2. Content................................................................................................................................ 2 

3. Proposal for the First Stage of Priority Setting for Greatest Potential for Exposure.......... 2 

3.1 The Limited Objective .................................................................................................. 2 

3.2 The Proposal ................................................................................................................. 3 

3.3 Basis for the Criteria for the Initial List of Prioritized Substances............................... 6 

3.4 Principles and Process by Which the Proposal Was Developed .................................. 7 

3.5 Nature of Substances Prioritized for Further Consideration......................................... 8 

3.6 Confidence and Limitations.......................................................................................... 9 

4. Next Steps ......................................................................................................................... 14 

5. Invitation to Comment ...................................................................................................... 15 

6. Background to CEPA 1999 Priority Setting for Health Risk Assessment for Existing 

Substances......................................................................................................................... 16 

7. Glossary ............................................................................................................................ 20 

8. References......................................................................................................................... 26 

List of Figures 

Figure 1: Schematic representation of the proposed first stage of priority setting for GPE........... 5 

Figure 2: The Existing Substances Program under CEPA 1999 .................................................. 17 

Figure 3: Types of substances on the DSL ................................................................................... 21 

List of Tables 

Table 1: Distribution of substances on the DSL by quantity code (1986 data).............................. 6 

Table 2: Types of substances initially prioritized for further consideration by the approach 

outlined in the proposal .................................................................................................... 8 

Table 3: Number of substances prioritized by the proposed approach according to the 20 use 

codes ranked highest for exposure potential................................................................... 10 

List of Appendices 

Appendix A: Substances Initially Prioritized by the Proposed Approach.................................... 27 

Appendix B: Tables of Functional Use Codes, Industrial Sector Codes and Quantity Codes ..... 63 

Appendix C: Development of the Use Code Indices and Ranking of Functional Use and 

Industrial Sector Codes for “Potential for Human Exposure”................................. 66 

Supporting Documentation 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

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 The following reports constitute supporting documentation to this proposal: 

• Report on Workshop to Consider DSL Industrial Sector and Functional Use Codes as 

Indicators of Potential Human Exposure, 1st Workshop (Government Experts), May 30, 

2000. 

• Report on Workshop to Consider DSL Industrial Sector and Functional Use Codes as 

Indicators of Potential Human Exposure, 2nd Workshop (Industry Experts), October 18, 

2002. 

• E. Doyle, H. Patterson, A Study to Determine Currency of DSL Quantity Data for Use in 

Categorization of DSL Substances, Report prepared by Exposure Assessment Section, 

Existing Substances Division, Health Canada, August 2001. 

 The above documents are available from the Existing Substances Division website at 

<http://www.hc-sc.gc.ca/exsd-dse> or on request from: 

 

Existing Substances Division 

Bureau of Environmental Contaminants 

Safe Environments Programme 

Health Canada 

Environmental Health Centre, Room 145 

Tunney’s Pasture 

Postal Locator: 0801C2 

Ottawa, ON K1A 0L2 

ExSD@hc-sc.gc.ca
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

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List of Acronyms and Abbreviations 

bw body weight 

CAS Chemical Abstracts Service 

CEPA 1988 1988 Canadian Environmental Protection Act 

CEPA 1999 Canadian Environmental Protection Act, 1999 

CPI Chemical Product Index 

DSL Domestic Substances List 

EPA Environmental Protection Agency (U.S.) 

GPE greatest potential for exposure 

HPV high production volume 

ICCA International Council of Chemical Associations 

IUR Inventory Update Rule 

OECD Organisation for Economic Co-operation and Development 

PSL Priority Substances List 

Q estimated annual quantity of use 

S number of submitters 

SIDS Screening Information Dataset 

SNAc Significant New Activity 

TSCA Toxic Substances Control Act 

U sum of use code indices 

UVCB substances of unknown or variable composition, complex reaction products and 

biological material 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

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1. Introduction 

The Canadian Environmental Protection Act, 1999 (CEPA 1999)1

 requires 

categorization (Section 73) of all of the approximately 23 000 substances on the Domestic 

Substances List (DSL) prior to a legally mandated deadline of September 14, 2006 (Government 

of Canada, 1999). This proposal outlines the first stage of priority setting for the requirement 

under the legislation for Health Canada to identify (i.e., “categorize”) those substances on the 

DSL that present the greatest potential for exposure (GPE) to Canadians. It is being released for 

a comment period to solicit input on both technical and management aspects relevant to its 

refinement and completion. 

As this is the first stage, there is a likelihood of additional stages to further refine 

priorities prior to the 2006 deadline for categorization. More discriminating stages of priority 

setting in GPE categorization, although not yet fully developed, are also outlined briefly to 

provide contextual reference, to encourage voluntary submission of relevant data for 

consideration and to solicit input on the proposed path forward. 

In considering this proposal, it is important to understand the limited objective of 

categorization in the overall mandate for Existing Substances under CEPA 1999. There are two 

additional phases of more detailed assessment for substances prioritized (categorized) for further 

consideration: namely, screening (Section 74) and Priority Substances (Section 76). Also, 

within the categorization phase, there is another independent stream that prioritizes substances 

primarily on the basis of environmental impacts (i.e., compounds considered to be persistent or 

bioaccumulative in the environment and inherently toxic to humans or to non-human organisms). 

Additionally, there are other streams through which substances can be prioritized for assessment: 

reviews of decisions of other jurisdictions (Section 75), nominations to the Priority Substances 

List (PSL) and advice provided to the Ministers of Health and the Environment by expert panels. 

In the interest of soliciting additional relevant information to permit refinement prior to 

2006, a draft list of initially prioritized substances is included in Appendix A. Inclusion on this 

list does not imply that these substances are the most hazardous or that exposure should be 

avoided; it simply indicates that they would be prioritized for additional consideration based on 

the criteria for the first stage of GPE prioritization delineated in this proposal. 

This is the first of three proposals that will be issued for public comment in relation to 

Health Canada’s responsibilities for categorization under CEPA 1999. A second proposal 

addressing priority setting for inherent toxicity to humans will be issued shortly. Based on 

comments and information received in response to both of these proposals, and taking into 

account additional stages of iterative priority setting that continue to be developed, a final 

integrated approach to categorization for both GPE and inherent toxicity to humans will be 

issued in the fall of 2005. 

 

1

 Terms identified by bolding and italics the first time they appear in the text are defined in the glossary (section 7). 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

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Written comments, which will be taken into consideration in revision of the proposal, 

should be submitted prior to March 31, 2004 to the Existing Substances Division website at 

<http://www.hc-sc.gc.ca/hecs-sesc/exsd/cat_dsl2.htm>. Comments can also be submitted to: 

 Existing Substances Division 

Bureau of Environmental Contaminants 

Safe Environments Programme 

Health Canada 

Environmental Health Centre, Room 145 

Tunney’s Pasture 

Postal Locator: 0801C2 

Ottawa, ON K1A 0L2 

ExSD@hc-sc.gc.ca 

2. Content 

Initially, the proposal for the first stage of priority setting for greatest potential for 

exposure (section 3) is outlined in the context of its limited objective and the principles and 

process by which it was developed. This is followed by an indication of potential next steps 

(section 4) and an invitation to comment (section 5), which includes specific relevant questions 

for consideration to focus the attention of the reviewers, although comment on all aspects of the 

proposal is invited. Background information is then presented (section 6) to set the context of 

relevant requirements under CEPA 1999 and the relationship of this component of the program 

with iterative subsequent stages of fuller health assessment of Existing Substances. A glossary 

(section 7) is included to explain important terms in the report; these terms are identified in the 

text by bolding and italics. References cited in the text are listed in section 8.

Substances that have been initially prioritized by the proposed approach are presented in 

Appendix A. Appendix B lists DSL functional use and industrial sector codes (use codes and 

DSL codes for quantity of use ranges), whereas Appendix C describes the derivation of and lists 

the use code ranking indices. Supporting documentation includes the reports of two workshops 

in which the exposure potential of individual use codes was ranked and A Study to Determine 

Currency of DSL Quantity Data for Use in Categorization of DSL Substances. 

3. Proposal for the First Stage of Priority Setting for Greatest Potential for Exposure 

3.1 The Limited Objective 

While there are several other streams by which Existing Substances can be prioritized for 

assessment, categorization of substances on the DSL is unique in that it is the only stream for 

assessment that makes provision for systematic consideration of all Existing Substances in 

Canada to establish priorities for further work (e.g., data generation and assessment). For this 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

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reason, the proposal outlined below embodies the principle that all substances should be treated 

equally to ensure that there is no bias preventing further consideration of substances for which 

data are currently limited or unavailable. This approach fulfils the fundamental objective of the 

categorization provisions of CEPA 1999 to avoid continued emphasis on the limited numbers of 

Existing Substances for which there is information on exposure and effects. However, this does 

not preclude additional data being taken into consideration in subsequent priority-setting stages 

before the 2006 deadline for categorization. 

 

Hence, the proposed first stage of priority setting in the GPE categorization is simple and 

pragmatic to ensure that all substances are addressed, based on comparable existing information. 

This information, which derives from that submitted at the time the DSL was compiled, is 

limited. Indeed, it is the constraints under which the DSL was compiled and the limitations of the 

information submitted at that time that constitute some of the most significant shortcomings of 

this proposal (Environment Canada, 1988). 

Information for each substance on the DSL is restricted to the following: 

• Chemical Abstracts Service (CAS) registry number; 

• chemical name (CAS naming convention); 

• names of organizations or persons notifying information (submitters); 

• codes representing the functional use of a particular substance (functional use codes) and/or 

the industrial sector in which it was used (industrial sector codes) (Appendix B, Table B1); 

and 

• a coded estimate of the quantities of a particular substance in use (manufactured, imported 

and used in Canada) during the reporting period defined in the Act (1984–1986), as supplied 

by each submitter in codes representing order-of-magnitude ranges (Appendix B, Table B2). 

The limitations of the information available for each of the substances on the DSL 

preclude all but the crudest distinctions with respect to potential for exposure. However, the 

information does enable consideration of quantity in commerce, numbers of submitters and use 

codes. These criteria permit crude priority setting in the context of GPE in that they allow 

identification of substances produced or imported in the greatest quantities for which uses could 

be dispersive in the environment or which are used in products that come into direct contact with 

the general population. This offers an improvement over, for example, the single criterion of 

quantity, which has been used as the basis of priority setting for voluntary testing programs for 

existing substances internationally. 

3.2 The Proposal 

The proposal is based on three different lines of evidence, derived from the limited 

information provided for all substances on the DSL: namely, quantity (estimated annual quantity 

of use, Q), number of submitters (S) and use (sum of use code indices, U). 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

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For quantity (Q), annual quantities of use were reported for each substance by each 

submitter in codes representing order-of-magnitude ranges. The high end of the range for 

quantity of use for each substance reported by each submitter was summed for all submitters, 

resulting in total quantities of use for each substance ranging from 0 to greater than 109

 kg/year 

(106 tonnes/year). All 22 264 substances on the DSL were then ranked in descending order on 

this basis. Log quantities ranged from 8.4 to 0 (Figure 1). 

All 22 264 substances on the DSL were also ranked in descending order on the basis of 

their number of submitters (S). The number of submitters ranged from 102 to 1 (Figure 1). This 

parameter was included on the premise that, if a substance is being used by a large number of 

submitters, then it is likely to have more widespread distribution in Canada than a substance used 

by a smaller number of submitters. 

Development of the parameter related to use (U) was based principally on expert 

judgement. Individually, 33 experts were asked to rank each of the functional use and industrial 

sector codes as having “high,” “medium” or “low” potential for exposure.2

 An expert-ranked 

index was subsequently developed for each of the functional use and industrial sector codes 

through summation of the number of experts reporting each of “low,” “medium” and “high” 

potential for exposure multiplied by scaling factors of 1 for “low,” 10 for “medium” and 100 for 

“high.” This index was then normalized to a scale between 1 and 100 by dividing by the number 

of participants. The order-of-magnitude scaling factors, although principally arbitrary, were 

chosen to increase the spread of values for the indices of use and to bias the weighting to those 

uses considered by experts to have the greatest potential for exposure. 

For use (U), all 22 264 substances on the DSL were ranked in descending order on the 

basis of their sums of normalized indices of expert-ranked functional use and industrial sector 

codes for each substance. The sum of the use indices for each substance ranged from 13 227 to 0 

(Figure 1). 

The criteria for initial prioritization proposed for each of these lines of evidence are 

quantity of use (Q) ≥1 000 000 kg/year (2413 substances); the top 10% of the rank order of the 

number of submitters (S) (≥4 submitters) (2665 substances); and the top 10% of the rank order of 

indices of use (U) (score ≥414.1) (2226 substances). Substances would be considered as 

priorities for further consideration only if they met the criteria for each of the three lines of 

evidence (Figure 1). 

A schematic representation of the proposed approach to the first stage of priority setting 

for GPE is presented in Figure 1. 

 

2

 The workshop used the terms “greatest,” “intermediate” and “least”; for clarity, the equivalent terms “high,” 

“medium” and “low” are adopted in this proposal. 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

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Figure 1: Schematic representation of the proposed first stage of priority setting for GPE 

8.4

4.3

3

2

0

102

2

1

13227

189

94.5

58.4

0

Prioritization criterion

1 000 000 kg/year

Prioritization criterion

10% (4 Submitters)

Prioritization criterion

Q 10% (Score of 414.1)

Q

S

S

U

U Draft list of 849 substances from

the first stage of prioritization

for further consideration

Quantity

(Log)

Number of

Submitters

Σ Use Code

Indices

Quantity

Number of

Submitters

Σ Use Code

Indices

(2413 substances)

(2665 substances) (2226 substances)
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

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3.3 Basis for the Criteria for the Initial List of Prioritized Substances 

The proposed criterion for quantity (Q) is consistent with those adopted internationally.

This aspect is important in ensuring that the DSL program contributes to efficient use of global 

resources to address the significant task of setting priorities for testing and assessment of all 

Existing Substances. However, limitations of reporting for the DSL preclude meeting this 

objective fully. 

Based on the proposed procedure for the estimation of Q, the numbers and proportions of 

substances in each quantity range are presented in Table 1. The DSL quantities are reported in 

order-of-magnitude ranges, and the high end of the quantity range for each substance reported by 

each submitter was summed for the total quantity for a particular substance. Hence, a value of 

≥1 000 000 kg/year prioritizes for further investigation all substances that were definitely in use 

at over 100 000 kg/year based on 1986 submissions. On this basis, 2413 (10.8%) of the 22 264 

substances on the DSL met or exceeded this criterion for prioritization. (In other words, the 

numbers of substances in the quantity ranges designated by codes F and G in Table 1 constitute 

those in use at over 100 000 kg/year in Canada. This is due to the total quantities for each 

substance representing the sums of the maximum values from the order-of-magnitude ranges 

reported by each submitter for each use code.) 

Table 1: Distribution of substances on the DSL by quantity code (1986 data) 

Code Quantity range (kg) Number of substances in quantity 

ranges using proposed procedure 

% of substances in 

quantity ranges 

G Over 10 000 000 1198 5.4 

F 1 000 000 – 10 000 000 1215 5.4 

E 100 000 – 1 000 000 2354 10.6 

D 10 000 – 100 000 5094 22.9 

C 1 000 – 10 000 5231 23.5 

B 100 – 1 000 763 3.4 

A Under 100 3827 17.2 

N Nila 2582 11.6 a Substance did not meet eligibility criteria in 1986, but did meet eligibility criteria in 1984 or 1985. No import, manufacture or 

in-commerce activity in 1986 (i.e., substance quantity was zero). Used where import amount or manufacture amount exceeded 

100 kg in 1984 or 1985, but was less than 100 kg in 1986.

The proposed criterion for Q is aligned to the extent possible with the quantities that 

define high-production-volume (HPV) chemicals in voluntary testing programs internationally: 

namely, the HPV Chemical challenge program of the U.S. Environmental Protection Agency 

(U.S. EPA) and the International Council of Chemical Associations (ICCA) HPV working list. 

For the former, the relevant criterion for inclusion is production or import in volumes greater 

than 1 000 000 lbs./year (approximately 450 000 kg/year); for the latter, this value is greater than 

1000 tonnes/year (1 000 000 kg/year). The proposed criterion is also consistent with the 

approach proposed by the European Commission in its REACH plan (European Commission, 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

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2003); the European Commission will require all substances produced in quantities of greater 

than 100 tonnes/year (i.e., 100 000 kg/year) to be evaluated, which is similar to the criterion 

proposed here that prioritizes all substances definitely in use at over 100 000 kg/year. 

The proposed criteria for S (number of submitters) and U (use) are arbitrary, but 

consistent with that adopted for Q (quantity of use). The value proposed is the top 10% of all 

substances on the DSL ranked in descending order on the basis of each of these parameters. The 

result is 2665 substances being prioritized based on the number of submitters (S) and 2226 

substances being prioritized based on the sum of weighted use code indices (U). Although the 

choice of 10% for these parameters is arbitrary, the number of DSL substances that are 

prioritized in each case is similar to the number prioritized under the criterion for quantity (Q) 

(2413 substances, 10.8%). 

3.4 Principles and Process by Which the Proposal Was Developed 

The proposed approach makes maximal use of the limited data available for all 

substances on the DSL, drawing separately on as many different lines of evidence as possible. 

Substances will be considered as priorities for further consideration only if they meet the criteria 

proposed above for each of the three lines of evidence: namely, quantity (Q), number of 

submitters (S) and use (U) (Figure 1). This offers considerable advantage over existing 

prioritization schemes in international testing initiatives, which are based solely on volume of 

production. Owing to the limitations of data available for all substances on the DSL, no other 

independent lines of evidence were identified. 

With the exception that expert judgement is incorporated in the development of the 

parameter for use (U), the proposal is based on “mechanically” generated indices for 

prioritization. This does not preclude consideration of additional expert judgement in potential 

subsequent stages of refinement. 

Of the three lines of evidence suggested as a basis for initial priority setting in this 

proposal, expert judgement was incorporated only in the development of the expert-ranked 

normalized indices of use (U). In developing the indices, two workshops were organized, for 

which the reports are available as supporting documentation. An expert-ranked use code index 

was developed based on the degrees of consensus that each use code reflected “high,” “medium” 

or “low” potential for exposure based on predefined criteria. The methodology by which the 

indices were developed, based on the conclusions of the workshops, and a list of these rankings 

are provided in Appendix C. 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

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In the derivation of this index, the weighting of the expert judgements representing 

“low,” “medium” or “high” potential for human exposure is primarily arbitrary. These three 

categories were weighted in 10-fold increments — i.e., 1 for “low,” 10 for “medium” and 100 

for “high.” The increment was selected to increase the spread of values for the indices of use and 

bias the rank order values to those uses considered by experts to have greatest potential for 

exposure. This latter reason is consistent with the objective to identify highest quantity 

substances for which uses are dispersive in the environment or which come into direct contact 

with the general population. 

3.5 Nature of Substances Prioritized for Further Consideration 

Application of the approach advocated within this proposal results in 849 substances 

being initially prioritized for further consideration. (These substances are listed in Appendix A 

by chemical class.) The distribution of the different types of substances prioritized on this basis 

is presented in Table 2. 

Table 2: Types of substances initially prioritized for further consideration by the approach outlined in the 

proposal 

Chemical categorya Top 10%

Organic 314 37% 

Inorganic 149 18% 

Organometallic 3 <1% 

Organic-metal salt 5 <1% 

Polymer 111 13% 

UVCB 267 31% 

Total 849 100% 

a

 Chemical categories are defined in the Glossary (section 7). 

While the substances included in Appendix A seem reasonable priorities for initial 

consideration, it is also important to recognize the broader value of the methodology presented in 

this proposal in priority setting based on initial consideration for all substances in the Existing 

Substances Program. Consistent with the longer-term objective to consider hazard and risk for all 

Existing Substances, the methodology is also relevant to development of additional tiers of 

priority setting. For example, the next highest priorities for consideration might be those for 

which the criterion for Q is selected as 100 000 kg/year. If applied along with the other two 

criteria for S and U in this proposal, an additional 407 substances would be prioritized for 

further consideration. This would include all substances definitely in use in Canada at over 

10 000 kg/year, because of the summation of the high end of order-of-magnitude quantity 

ranges. 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

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3.6 Confidence and Limitations 

Alternatives Considered 

The option presented here was that preferred based on consideration of a series of 

alternatives. In one of two other alternatives considered, each of quantity (Q), the number of 

submitters (S) and the sum of the normalized indices of expert-ranked use codes (U) for each 

substance was ranked in descending order (from 22 264 to 1). For each substance, the ranking 

for each of these parameters was summed (Q + S + U), and the substances were then ranked in 

descending order of the combined score. Substances were prioritized for further consideration if 

they had a score above 90% of the theoretical maximum score (n = 1399 substances). While this 

approach draws on all three lines of evidence, it does not do so maximally. Substances that score 

very high on two criteria but only in approximately the top 30% on the third are prioritized for 

further consideration. 

In an additional option considered, the criteria for prioritization varied. The number of 

submitters (S) was ranked in descending order, and those for which the value was ≥4 were 

prioritized. The criterion for total quantity (Q) was 100 000 kg/year. For the sum of the use code 

indices, an expert-ranked index value of ≥70 was selected to represent use codes with high 

dispersive use, and a criterion for prioritization of 299 was established by multiplication of this 

value by the average number of use codes for the substances on the DSL (4.26). Then, for each 

substance, only submitted use codes with indices greater than 70 were summed, and only 

substances with a total score ≥299 were prioritized for this line of evidence. This resulted in 

1531 substances common to all three lines of evidence prioritized for further consideration. 

While this alternative also draws on all three lines of evidence, it does not maximize use of the 

information on use patterns and is based on additional subjective judgement about which use 

codes represented high dispersive use. 

Weighting of the use codes by accompanying data on volume of use and allocating 

volumes across the submitted use codes were also considered. These approaches were abandoned 

because they did not maximize drawing from different lines of evidence, leading to double 

counting of quantity. This created bias to prioritization of higher-quantity substances, excluding 

those with lower reported quantities but higher use code indices. The approaches also required 

many arbitrary decisions resulting from the limitations in the manner in which use codes and 

quantities were reported in the compilation of the DSL. 

Confidence Validation 

Compounds identified on the basis of this proposal are consistent with those expected 

based on its limited objective and constitute reasonable initial priorities for further consideration.

The limited objective of this proposal, as stated above, was to prioritize, on the basis of similar 

information available for all substances on DSL, those substances produced or imported in the 

greatest quantities for which uses could be dispersive in the environment or which come into 

direct contact with the general population. For the subset of 849 substances (3.8%) prioritized 

based on application of the approach within this proposal, Table 3 presents the number of 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

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substances for which the top 20 use code indices (Appendix C) were reported by one or more 

submitters. Information in the table supports prioritization, on the basis of the proposal, of 

substances for which uses could be dispersive in the environment or which are used in products 

that come into direct contact with the general population. 

Table 3: Number of substances prioritized by the proposed approach according to the 20 use codes ranked 

highest for exposure potential 

Use 

code 

Description Use code index Number of 

substances 

22 Fragrance/perfume/deodourizer/flavouring agent 94.55 395 

46 Surfactant – detergent/emulsifier/wetting agent/dispersant 86.36 229 

93 Soap and cleaning products 85.19 305 

53 Agriculture, field crops 82.29 52 

44 Solvent/carrier 80.91 256 

82 Petroleum and natural gas 78.81 328 

23 Fuel/fuel additive 78.18 110 

31 Pesticide/herbicide/biocide/disinfectant/repellant/attractant 78.18 72 

39 Preservative 77.91 34 

60 Cosmetics 73.29 175 

65 Food, feed, and beverage 72.71 165 

81 Pest control products, formulating and manufacture 70.39 65 

30 Paint/coating additive 69.18 285 

63 Fertilizer 67.77 46 

91 Refined petroleum and coal products 67.77 188 

64 Forestry/wood products/wood treatment 66.90 20 

13 Colourant – pigment/stain/dye/ink 66.73 224 

97 Water and waste treatment 64.58 120 

54 Agriculture, other 63.13 51 

83 Pharmaceuticals 61.39 124 

Substances prioritized also overlap with those being considered in international 

initiatives. Of the 849 substances that would be prioritized based on this proposal, 549 (65%) are 

included on either the U.S. EPA HPV Challenge Program List (463 substances, 55%) or the 

ICCA HPV 2003 Working List (313 substances, 37%) (Appendix A). The numbers of each type 

of substance not on either of these lists (in 2003) are organics (30), inorganics (73), polymers 

(104), UVCBs (93) and organic-metal salts (1). Differences are likely attributable principally to 

inclusion in this proposal of additional lines of evidence (i.e., U and S). Criteria in this proposal 

are also applied to all of the various types of substances on the DSL, including inorganics and 

polymers, which were excluded from other programs. The sizes of the source lists from among 

these initiatives also vary considerably. 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

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There are limited possibilities to compare the output of this first stage of priority setting 

with the outcome of more complete assessments of exposure due, in part, to the limited 

availability of data to serve as a basis for such assessments and the lack of a requirement for 

quantitative multimedia exposure assessments in most jurisdictions. Indeed, the repository of 

multimedia exposure assessments for the first and second PSLs is the most robust and complete 

of the relevant databases identified. 

To consider the robustness of the proposal for the first stage of priority setting, then, the 

absolute values and rank order for each of the lines of evidence in this proposal were compared 

with deterministic estimates of exposure (minimum, mean and maximum intake in μg/kg-bw per 

day) for each of 37 Priority Substances on the first and second PSLs for which this was possible. 

This information was analysed particularly with reference to those substances on the PSL that 

are prioritized on the basis of the proposal presented here (n = 30) versus those that are not (n = 

7). Lack of prioritization of substances correlated roughly with very low deterministic estimates 

of exposure in the general environment (<1 μg/kg-bw per day) and no identified consumer 

product uses. Exceptions for PSL substances with high deterministic estimates of exposure that 

would not be prioritized by the approach presented here either were naturally occurring 

inorganic substances or could be attributed to likely considerable quantitative overestimates of 

exposure related to limitations of the database. To the limited extent to which it can be 

examined, then, the compounds captured based on the first-stage proposal presented here are 

considered to be true priorities for additional work. 

Limitations 

The most significant limitation of the current proposal relates to the potential lack of 

prioritization of substances that should be considered additionally in the context of potential risk 

to human health. However, it is likely that these substances will be prioritized for consideration 

through other streams within the Existing Substances Program. 

 The proposed approach does not identify for future work: 

• substances whose major source is from articles or finished products imported into Canada, 

unless the reported quantities and uses in Canada during compilation of the DSL were 

sufficiently high to lead to their identification; 

• substances primarily used or produced in industrial processes, which are released in 

effluents, emissions, wastes and by-products and are not used substantially in consumer 

products; 

• environmental contaminants from releases of substances regulated under an Act of 

Parliament other than CEPA 1999 or that are present in Canada through long-range transport 

through the atmosphere or aquatic systems; 

• substances produced as reaction or decomposition products from industrial or natural 

processes; and 

• substances that have come into high quantity and/or widespread consumer use since the 

publication of the DSL as a result of technological change or response to market demands. 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

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 This limitation is a function of the fundamental premise underlying this proposal that, in 

the initial stages, all Existing Substances must be addressed in similar fashion to ensure that true 

priorities for both testing and assessment are identified. This necessarily limits the information 

available as a basis to set priorities and permits only crude priority setting in an exposure 

context. 

 However, this limitation is offset by other provisions under CEPA 1999 to identify 

priorities for assessment. Any substance not identified by the GPE proposal — for example, a 

substance within one of the groups identified above — could be identified and considered further 

under one or more of these alternative streams. For example, under Subsection 73(b), a separate 

stream of DSL categorization, substances are prioritized on the basis of potential for persistence 

and/or bioaccumulation and being inherently toxic to humans or non-human organisms. This 

stream is potentially more relevant to identification of candidate substances released in effluents, 

emissions, wastes and by-products. Similarly, through the same priority-setting stream, a DSLlisted substance in articles or products or present in Canada through long-range transport could 

be identified as a priority. Also under Section 75, the Ministers of Health and Environment are 

required to review decisions to specifically prohibit or substantially restrict any substance by or 

under the legislation of another jurisdiction for environmental or health reasons. Finally, under 

Subsection 76(3), any person may file in writing with the Minister of the Environment a request 

that a substance be added to the PSL, and the request shall state the reasons for adding the substance 

to the List. 

The second most significant limitation of the proposal relates to the constraints under 

which the DSL was compiled and the limitations of the information submitted at that time.

Although the information provides a basis for at least crude relative ranking of potential for 

exposure for all substances on the DSL, the nature and specificity of the submitted data on use 

codes and quantity of use were limited. For the use codes, this includes their relevance as a basis 

for consideration of potential for exposure and the potential lack of consistency in their 

application. Major ingredients of products may also not have been identified. 

 The functional use and industrial sector codes were not designed with the intent of 

identifying the potential for exposure of the general population. For example, use codes such as 

number 25 (humectant/dewatering aid/dehumidifier/dehydrating agent) are not specific in 

indicating use in consumer products or industrial use. Specificity of the information was also 

limited by a maximum number of use codes that could be submitted. Identification of substances 

that are major ingredients in products was also limited by the approach to compilation of the 

DSL. 

 Guidance provided on the interpretation and reporting of functional use or industrial 

sector codes in the compilation of the DSL was also limited, and there was considerable 

variation in reporting by different submitters. A significant fraction reported only one code for 

each substance (i.e., either a functional use or industrial sector code). Most reported two or three 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

13

codes distributed across functional use or industrial sector codes. For an individual substance, a 

variety of possible interpretations of use and, therefore, combinations of codes was possible. 

This may have resulted in some substances being over- or underrepresented in particular use or 

industrial sector categories. 

 With respect to the information on quantity of use, there are two major limitations. The 

first relates to the process by which the DSL was compiled, and the second to the reporting of 

the quantity of use in order-of-magnitude ranges only. The process by which the DSL was 

compiled (see “Domestic Substances List” in Glossary) may have led to the underreporting of 

quantities for some substances. In the compilation of the core DSL, major Canadian companies 

nominated substances likely produced and/or imported in the highest quantities. Substances 

nominated with quantities between 100 and 1000 kg/year required no further nomination from 

other companies. The impact of this potential underreporting on priority setting is expected to be 

minimal, as the substances produced and/or imported in highest quantities were likely to have 

been reported by the larger companies in compilation of the core DSL. 

 The reporting of quantities of use in the compilation of the DSL in order-of-magnitude 

ranges only limits accuracy of the information on quantity of use (Q) as a basis for prioritization. 

Due to lack of point estimates of quantity of use, Q for each substance is based on summation of 

the high end of the quantity range reported by each submitter. This introduces bias to 

overestimation, since actual quantity could be any value within the reported range. The 

recommendation of the ≥1 000 000 kg/year criterion for prioritization also biases to 

conservatism, leading to the prioritization of more substances for further work than adoption of a 

less conservative value of 10 000 000 kg/year to capture substances definitely in commerce in 

Canada in 1986 at a quantity of over 1 000 000 kg/year. 

 The lack of currency of the information submitted during compilation of the DSL, which 

was based on data for the period of 1984–1986, is also a potentially significant limitation of this 

proposal. However, based on consideration of readily available information for a limited number 

of substances, quantities and patterns of use have not changed dramatically. 

 Data included in Chemical Product Index (CPI) profiles obtained from Camford 

Information Services for a selected list of 110 substances, including organic and inorganic 

substances as well as polymers, were compared with information submitted in the compilation of 

the DSL (see supporting documentation by Doyle and Patterson). These profiles provide both 

current and past supply and data on demand for chemical substances in Canada and are compiled 

on a regular basis based on both published trade data and industry interviews. Conclusions based 

on the analysis, reported in more detail in the supporting documentation, are that for only 7 of 

the 110 substances were there increases or decreases in supply greater than a single order of 

magnitude over the reporting period. The reporting periods were from 1986 to the most recent 

year for which data was provided for a particular substance, ranging from 1989 to 1999. The 

quantities reported in 1986 in the compilation of the DSL are considered reasonable initial 

estimates of those currently, with accuracy within at least one order of magnitude. The numbers 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

14

of Section 71 reports for substances in the DSL Pilot Project (Government of Canada, 2001a), 

completed at the time of posting of this proposal, were inadequate as a basis for meaningful 

comparison with the information included on the DSL. 

 The proposal, which is based on specified criteria for prioritization for Q, S and U, some 

of which are arbitrary, incorporates some expert judgement and arbitrary weightings and 

generates a subset of the DSL on which to focus further attention. Merits of this proposal need to 

be judged against the alternative of systematic compilation of more recent information from 

industrial stakeholders on the current use of all Existing Substances in Canada. In view of the 

significant resources and workload required to undertake such an exercise, the approach 

proposed here is favoured. It permits focusing of attention for information gathering or 

submission on a reduced list of substances prioritized as having greater potential for exposure to 

humans. 

4. Next Steps 

Potential additionally more discriminating steps of priority setting in categorization, 

although not yet fully developed, are outlined briefly below in order to provide contextual 

reference, to encourage voluntary submission of relevant information and to solicit input on the 

proposed path forward. 

Substances prioritized for further consideration on the basis of this proposal that have 

been considered in PSL1 or PSL2, have been included in the pilot phase for screening 

assessments in the DSL program or are already on CEPA 1999 Schedule 1 are indicated in 

Appendix A. For ease of reference, those included on the U.S. EPA and ICCA HPV lists are also 

indicated. Projected timelines for completion of voluntary testing on the substances in these 

programs are relevant to scheduling, particularly for substances still considered as priorities for 

further work beyond the 2006 deadline for categorization. 

In total, 49 substances on the initial list have previously been assessed and/or subject to 

risk management. Further evaluation of these substances is not being proposed at this time.

Thirty (30) of the substances have been reviewed in the PSL evaluation programs (PSL1 and 

PSL2) under the original Canadian Environmental Protection Act (CEPA 1988) or CEPA 

1999, 27 substances are on Schedule 1 of CEPA 1999 and an additional 5 substances are on 

Schedule 3 of CEPA 1999. An additional 19 substances are already under evaluation within the 

DSL pilot phase of screening assessments. 

In subsequent stages and prior to the 2006 deadline for categorization, identification of 

priorities for additional work will be further refined. This will include consideration of both 

toxicity (at least crudely) and refined measures of exposure to ensure that substances prioritized 

are those likely to pose the greatest risk. The initial measure of toxicity to human health being 

considered in this context is that being developed for the other stream of categorization of the 

DSL, where substances considered to be persistent or bioaccumulative and “inherently toxic” to 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

15

human health are being identified. Cruder indicators, such as the “threshold of toxicity,” are also 

being considered. In relation to additional refinement of exposure, crude quantitative estimates 

may be developed on the basis of generic scenarios for particular functional use and industrial 

sector codes for groups of substances with similar chemical structure and/or use. 

Polymers could be further considered on the basis of criteria similar to those established 

in the New Substances Notification Regulations under CEPA 1999, which define those of low 

concern for human health (Government of Canada, 1994, 2001b). Other options also being 

considered include identifying all polymers on the DSL for which use in aerosols is likely. Both 

of these options require submission of additional information concerning the characteristics and 

use patterns of polymers, and a request for submission of a proposal concerning an envisaged 

mechanism of coordination of submission of relevant data has been sent to the CEPA Industry 

Coordinating Group.

UVCBs prioritized for further consideration on the basis of this proposal could be 

examined on a case-by-case basis. This examination, on the basis of expert judgement 

documented by a detailed and transparent rationale, would identify those that can be “set aside” 

from further consideration because of known low toxicity, those for which requests will be made 

to industrial stakeholders to provide additional information and those for which attempts will be 

made to identify additional relevant data on toxicity. 

5. Invitation to Comment 

Views and suggestions are invited on all aspects of the proposal. Specific aspects for 

which input would be helpful are outlined in the questions below. Written comments, which will 

be taken into consideration in revision of the proposal, should be submitted prior to March 31, 

2004, as indicated above in section 1. 

The following are some questions to guide commentary: 

i) Is the proposed approach sufficiently transparent and discriminating with respect to how 

substances have been selected for further consideration in the first stage of priority 

setting? 

ii) Does the proposed approach maximize the use of the available information for all 

substances on the DSL in identifying those with the greatest potential for exposure? If 

not, what other options should be considered? 

iii) Can other information or data for all of the 22 264 substances on the DSL be identified 

that would be helpful in determining whether a substance should or should not be 

prioritized for further consideration on the basis of greatest potential for exposure? 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

16

iv) Are there reasons why any one of the three lines of evidence is inappropriate for use in 

the first stage of priority setting for greatest potential for exposure? Can you envisage 

other potential lines of evidence based on the limited information on each compound 

submitted in the compilation of the DSL? 

v) Is equal weighting of the three lines of evidence, quantity (Q), number of submitters (S) 

and use (U), presented in this proposal appropriate, or can a preferred alternative be 

identified and justified? 

vi) Do the proposed criteria for prioritization for each of the lines of evidence represent a 

reasonable compromise for establishing initial priorities for further consideration? 

vii) Can you suggest specific approaches to additional priority setting for substances within 

the groups of organics, inorganics, polymers and UVCBs for compounds prioritized in 

the first stage? Can you identify relevant sources of information or supply relevant data? 

6. Background to CEPA 1999 Priority Setting for Health Risk Assessment for Existing 

Substances 

The Canadian Environmental Protection Act, proclaimed in 1988 (CEPA 1988) and 

amended in 1999 (CEPA 1999), provides the primary authority and policy direction for the 

assessment and management of environmental contaminants in Canada. Among its many 

provisions, CEPA 1999 requires that the Ministers of Health and of the Environment take action 

with respect to the control or management of toxic substances that may already be present in the 

Canadian environment (i.e., Existing Substances). The Act provides the framework for the 

identification/prioritization of Existing Substances for risk assessment and the control or 

management of those considered to pose a risk to human health and/or the environment. This 

framework is broad, evidence-based, open and transparent and builds upon work done in other 

jurisdictions. 

The mandate respecting Existing Substances has been vastly expanded under the renewed 

CEPA 1999 and specifies four ways in which Existing Substances may be identified for risk 

assessment (Figure 2): 

• categorization of substances on the DSL; 

• reviewing regulatory decisions of other jurisdictions; 

• requests made directly to the Minister of the Environment; and 

• advice provided to the Ministers of Health and of the Environment by expert panels. 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

17

Figure 2: The Existing Substances Program under CEPA 1999 

In addition to the continuing requirement to establish and assess lists of Priority 

Substances, CEPA 1999 requires that the Ministers of Health and Environment complete 

“categorization” of all of the 22 264 substances on the DSL by September 2006, with subsequent 

screening and full assessment, where warranted. Canada is the first country to introduce this 

legislative requirement for a systematic and iterative approach to priority setting for risk 

management for all Existing Substances, although legislative proposals whose intent is similar 

have been developed in at least one additional jurisdiction (European Commission, 2003). 

This requirement has been prompted in part by the earlier introduction of consideration 

of all New Chemicals (those not used in Canada between 1984 and 1986) under CEPA 1988 and 

similar legislation in other countries. It also logically extends experience gained during the 

selection of the second PSL (n = 25), which was based in part on systematic priority setting for a 

much larger subset of some 600 Existing Substances (Koniecki et al., 1997). 

Under CEPA 1999, all 22 264 substances on the DSL must be categorized by September 

2006 (Figure 2) to identify those that: 

• may present, to individuals in Canada, the greatest potential for exposure; or 

CATEGORIZATION of the 

Domestic Substances List (DSL) 

(First Phase) 

Decisions of 

Other 

Jurisdictions 

Public 

Nominations 

Ministerial 

Expert Panels 

No further action under this 

program CEPANo further action under this 

program 

CEPAIN-DEPTH ASSESSMENT - Priority Substances List (Third Phase) 

Risk Management 

Risk Management 

Greatest Potential 

for Human 

Substances that are Persistent or 

Bioaccumulative 

“Inherently Toxic” 

to Humans

“Inherently Toxic” to 

non-Human 

Organisms 

SCREENING ASSESSMENT (Second Phase) 

STAGE 1

STAGE 2

STAGE N-1

STAGE N

STAGE 3
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

18

• are persistent or bioaccumulative and inherently toxic to human beings or to non-human 

organisms. 

Health Canada has responsibility for determining substances with the “greatest potential 

for exposure” and those that are “inherently toxic to human beings.” Environment Canada is 

responsible for determining which substances on the DSL are persistent and/or bioaccumulative 

and inherently toxic to non-human organisms. 

To the extent possible, categorization will be based on available data; only in the 

subsequent screening and full assessment phases may testing be required under the legislation. 

This is primarily due to the large number of substances to be addressed and the relatively short 

mandated period for completion of the categorization phase. 

The three iterative phases for priority setting for risk management of Existing Substances 

specified under CEPA 1999 (presented in Figure 2) are “categorization,” “screening assessment” 

and “full (Priority Substances) assessment,” representing increasing levels of complexity. As 

indicated in Figure 2, the objective for the latter two phases — namely, screening and full 

assessment — is to determine whether a substance is “toxic” under the Act, which sets the stage 

for adding the substance to Schedule 1 (the List of Toxic Substances) and for reviewing options 

for controlling risks to human health and/or to the environment. 

As indicated in Figure 2, the second iterative phase of prioritization — namely, screening 

— will be conducted for substances that meet criteria for various aspects of categorization. All 

substances proposed for assessment will also be screened initially. The exact form and content of 

various types of screening assessments are still under development. As indicated in Figure 2, the 

principal objective of these screening assessments is to determine whether substances can be set 

aside (i.e., require no further action) or should be prioritized for full (i.e., Priority Substances) 

assessment or considered for risk management. In view of their limited objectives, therefore, 

decisions will be based principally on comparison of worst-case estimates of exposure and 

effect. If margins are wide, there would be no further action on the compound at this stage. If, 

however, margins are small, the substance would be nominated for inclusion on the PSL for 

preparation of a full assessment, based on more extensive analyses of available data. 

Recommendations based on the magnitude of the margins of exposure will take into full account 

confidence in the completeness of the identified databases on both exposure and effect, within a 

screening context. High-hazard substances may be considered “toxic” and prioritized for risk 

management. 

CEPA 1999 does not impose a statutory deadline for completion of the screening 

assessments. There is a five-year mandated time frame for full (i.e., Priority Substances) 

assessments from the time of their addition to the PSL to completion. 

CEPA 1999 incorporates several information-gathering provisions under which necessary 

information is and will be solicited from producers or importers to permit screening and full 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

19

assessments of Existing Substances. Data considered sufficient as a basis for assessment of 

hazard in a screening context for prioritized GPE organic substances will generally be similar to 

that included in the Organisation for Economic Co-operation and Development’s (OECD) 

Screening Information Datasets (SIDS)3

 and consistent with requirements for New Chemicals 

under CEPA. For full (Priority Substances) assessments, more extensive testing may be required. 

Also, options are currently being considered — for example, for substances not currently used in 

Canada, based on information submitted in response to Section 71 surveys in a pilot phase for 

screening. 

The documented approach to full (i.e., Priority Substances) assessments and their 

associated reports are available at the Existing Substances Division website: <http://www.hcsc.gc.ca/hecs-sesc/exsd>. 

While there are only three phases of priority setting and assessment referenced in CEPA 

1999 (categorization, screening and Priority Substances), it is apparent that the systematic 

consideration of priorities for risk assessment and management for all Existing Substances in 

Canada will likely entail more iterative stages than these broadly defined phases. Each phase 

named within the legislation will likely entail one or more additional iterative stages of priority 

setting (Figure 2). These various stages are being developed simultaneously, with emphasis to 

date on the first stage of priority setting in categorization, various iterations of “screening” and, 

previously, Priority Substances. 

For example, this proposal outlines the first stage for priority setting for GPE based on 

similar but limited information for all substances on the DSL. Priorities for further consideration 

will be additionally refined in subsequent stages prior to the mandatory deadline for 

categorization, likely based on consideration of both toxicity (at least crudely) and refined 

measures of exposure. This ensures that substances prioritized are those likely to pose the 

greatest risk. The number of iterative stages in categorization will be dictated in large part by the 

expediency with which additional relevant information can be secured. 

Similarly, screening assessments will reflect various iterations of complexity, depending 

upon the nature of available data and the magnitude of and confidence in the margins between 

worst-case estimates of exposure and effect. 

 

3

 The SIDS for mammalian toxicity includes acute toxicity and the combined repeated dose/reproductive toxicity 

screen and genetic toxicity (two endpoints, generally point mutations and chromosomal aberrations) (OECD, 2003). 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

20

7. Glossary 

Canadian Environmental Protection Act, 1988 (CEPA 1988) — This was an Act of Canada 

proclaimed in force on 30 June 1988. It was replaced by CEPA 1999. CEPA 1988 consolidated 

selected provisions and laws administered by Environment Canada. It replaced the 

Environmental Contaminants Act of 1975 and subsumed the Clean Air Act, the Ocean Dumping 

Act, the nutrient provisions of the Canada Water Act and certain provisions of the Department of 

the Environment Act.

Canadian Environmental Protection Act, 1999 (CEPA 1999) — CEPA 1999 is an Act of 

Canada respecting the protection of the environment and human life and health. 

Categorization (Section 73) — Under Section 73 of CEPA 1999, the Ministers of Health and of 

the Environment must categorize the substances on the DSL. The Minister of Health must 

categorize substances on the DSL to identify those that pose the greatest potential for exposure 

of the general population in Canada, as well as those persistent or bioaccumulative substances 

considered “inherently toxic” to humans. The Minister of the Environment must categorize 

substances on the DSL to identify those that are persistent or bioaccumulative and “inherently 

toxic” to non-human organisms. Screening assessments (see Screening (Section 74)) will be 

conducted for substances meeting these criteria. 

Core DSL — The core DSL is a preliminary version of the DSL published in August 1989, 

based on nominations received from the approximately 200 companies invited to report in Phase 

1 reporting. 

Domestic Substances List (DSL) — The DSL, which was published in 1994, is an inventory 

established primarily as a basis for distinguishing “existing” from “new” chemicals under CEPA 

1988. It comprised originally of 22 264 substances that were, between January 1, 1984, and 

December 31, 1986, used for manufacturing purposes, manufactured in or imported into Canada 

in a quantity of 100 kg or more in any calendar year. Roughly half of the DSL is composed of 

organic substances and the remainder of inorganic substances, organometallic substances, 

polymers and UVCBs. The distribution of substances on the DSL is illustrated in Figure 3.
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

21

Figure 3: Types of substances on the DSL 

Reporting for the DSL was carried out in two stages (Environment Canada, 1988). In the first 

stage, approximately 200 companies were contacted and asked to report substances they 

manufactured and/or imported in quantities greater than 100 kg/year during the reporting period. 

Their responses were used to compile a core DSL. In the second stage, manufacturers and 

importers that did not report in the first stage were asked to review the core list and report any 

substances that were not included on the list but were manufactured or imported during the 

reporting period; they were also required to report on any substances that were on the list and 

were manufactured or imported in quantities greater than 1000 kg/year. The results of the second 

stage were used to compile a provisional DSL, which, after review and corrections, became the 

current DSL. 

Existing Substances — Existing Substances are those that appear on the DSL under CEPA 1988 

published on May 4, 1994; see also New Chemicals. 

Functional Use Codes — See Use codes.

Greatest potential for exposure (GPE) — Categorization for GPE is based on the interpretation 

that the intent of the legislation was to prioritize for subsequent phases of assessment those 

substances on the DSL that are used in Canada at the highest quantities and for which uses are 

dispersive in the environment or which come into direct contact with the general population, 

thereby leading to the greatest potential for exposure. 

50%

10% 2%

18%

20%

Organics

Inorganics

Other

Polymers

UVCBs
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

22

ICCA HPV 2003 Working List — ICCA has launched a global initiative on HPV chemicals. To 

qualify, the chemicals need to be considered HPV or otherwise of interest in two or more 

regions, although chemicals of interest in only one region are also sponsored if, for example, 

they are identified as priority chemicals by national and/or regional authorities and are HPV 

chemicals in at least one region; they are chemicals for which assessments in other programs had 

been started but were delayed at early stages; or they fit into a category of chemicals that can be 

assessed together. The latest ICCA list (August 2003) contains 1325 chemicals, and the 2002 

ICCA list contained 1511; 1242 substances appeared on both lists. The latest list is available 

from <http://www.cefic.be/activities/hse/mgt/hpv/HPVlist2000.pdf> or 

<http://www.cefic.org/activities/hse/mgt/hpv/hpvinit.htm>. 

Industrial sector codes — See Use codes. 

Inorganic — Inorganic substances include inorganic salts, metallic moieties of organic-metal 

salts and all well-defined substances that do not contain carbon, except certain simple 

compounds such as carbon monoxide. 

New Chemicals — The DSL is the sole basis for determining whether a substance is new for the 

purposes of CEPA 1999. Substances on the DSL are considered to exist in Canadian commerce 

and do not require notification unless they are proposed for a Significant New Activity (SNAc), 

as indicated on the DSL. Substances not on the DSL are considered to be new to Canada and are 

subject to notification. The DSL includes the list published on May 4, 1994, in Part II of the 

Canada Gazette and all additions or deletions subsequently published in the Canada Gazette. 

Substances may be included on the DSL based on either of the following: 

• commercial use in Canada between January 1, 1984, and December 31, 1986 (Subsection 

66(1) of CEPA 1999); or 

• the government has received all the prescribed information under Section 81 of CEPA 1999, 

and an assessment by the departments has determined that no controls should be imposed and 

that the import or manufacture has commenced after the most comprehensive notification 

package was assessed or exceeded the prescribed volumes (Section 87 of CEPA 1999). 

Number of submitters (S) — For the purposes of this proposal, all 22 264 substances on DSL 

were ranked in descending order on the basis of their number of submitters (number ranged from 

102 to 1). 

Organic — Organic substances are well-defined carbon-containing compounds that can be 

defined or represented by a structure and molecular formula and organic moieties of salts. 

Organic-metal salts — Organic-metal salts contain a metallic moiety and an organic moiety 

generally linked by an ionic single bond. Compare with organometallics. 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

23

Organometallics — Organometallics are compounds that contain a metal covalently bonded to a 

carbon, as well as, for the purposes of categorization, all compounds where the metal has 

multiple bonds with oxygen, nitrogen or sulfur. Compare with organic-metal salts. 

Polymers — Polymers are substances that consist of: 

• molecules characterized by the sequence of one or more types of monomer units; 

• simple weight majority of molecules containing three or more monomer units that are 

covalently bound to one or more other monomer units or reactants; 

• less than a simple weight majority of molecules of the same molecular weight; or 

• molecules distributed over a range of molecular weights where the differences in the 

molecular weights are primarily attributable to differences in the number of units. 

Priority Substances (Section 76) — Priority Substances are designated Existing Substances for 

which the Ministers of Environment and Health must conduct an assessment and publish a report 

to ascertain whether they are “toxic” within five years of addition to the PSL. Since 1988, for 

Existing Substances under CEPA, the Ministers of Health and Environment have assessed 69 

substances (including a number of complex mixtures) on the first and second PSLs, deemed to 

be of highest priority with respect to health or to the environment. If, on the basis of a screeninglevel assessment, it is determined that a more detailed in-depth analysis of the risks to human 

health (or the environment) is warranted, a substance may be added to the PSL for a more 

rigorous and comprehensive assessment to determine whether the substance is or is capable of 

becoming “CEPA-toxic.” The Act mandates that PSL assessments must be completed within five 

years from the date on which the substance is added to the PSL. 

Quantity (Q) — For the purposes of this proposal, annual quantities of use were reported for 

each substance by each submitter in codes representing order-of-magnitude ranges (Appendix 

B). The high end of the quantity of use range for each substance reported by each submitter was 

summed for all submitters, resulting in total quantities of use for each substance ranging from 0 

to greater than 109

 kg/year (106 tonnes/year). All 22 264 substances on the DSL were then 

ranked in descending order on this basis.

Schedule 1 — Substances that are declared “toxic” under CEPA 1999 are placed on Schedule 1 

(List of Toxic Substances) of the Act. They are then considered for risk management measures, 

such as regulations, guidelines or codes of practice to control any aspect of their life cycle, from 

the research and development stage through manufacture, use, storage, transport and ultimate 

disposal. 

Schedule 3 — Schedule 3 of CEPA 1999 is the Export Control List. Sections 100–103 provide 

authority to control the export of substances regulated under CEPA 1999 or another Act of 

Parliament. Substances fall into three categories: 

1. prohibited substances; 

2. substances whose export is subject to an international agreement that requires the 

notification or consent of the receiving country; and 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

24

3. restricted substances. 

Screening (Section 74) — Under Section 74 of CEPA 1999, the Ministers of Health and of the 

Environment must conduct screening assessments on each of the substances identified from the 

categorization of substances on the DSL. Screening assessments of risk will also be conducted 

on candidate substances from all streams, including those meeting criteria outlined under Section 

75 of CEPA 1999. Screening assessments set the stage for further in-depth assessment or risk 

management. They will involve a comparison of exposure and effect in a priority-setting context. 

The outcome of screening assessments is discussed in Section 77 of CEPA 1999. 

Section 75 — CEPA 1999 requires both Ministers to review the decisions of other jurisdictions 

to prohibit or substantially restrict a substance for environmental or health reasons and determine 

whether the substance is or is capable of becoming “CEPA-toxic.” 

Section 77 — Under Section 77 of CEPA 1999, the outcome of a screening assessment may be 

1) to take no further action on the substance, 2) to add the substance to the PSL for a more indepth assessment or 3) to recommend that the substance be added to the List of Toxic 

Substances. Under Section 77, the proposed result of a screening assessment and a summary of 

the scientific considerations upon which the proposal is based must be published for public 

comment. 

Submitters — Submitters are all Canadian manufacturers, importers and/or users who nominated 

and provided information on substances for listing on the DSL.

Substance — Under CEPA 1999, “substance” means any distinguishable kind of organic or 

inorganic matter, whether animate or inanimate, and includes: 

• any mixture that is a combination of substances; and 

• any complex mixtures of different molecules that are contained in effluents, emissions or 

wastes that result from any work, undertaking or activity. 

This definition of a substance therefore encompasses discrete chemical compounds, classes of 

chemicals, emissions and effluents and products of biotechnology, including microorganisms. 

Toxic — According to the CEPA 1999 legislation for human health, a substance is toxic if it is 

entering or may enter the environment in a quantity or concentration or under conditions 

constituting or that may constitute a danger in Canada to human life or health. This legal 

definition of “toxic” under CEPA 1999 may be equated with risk, since it embodies the concept 

that harm to human health is a function of both the intrinsic toxicity (i.e., toxicity in the 

traditional sense) and the extent of exposure. 

Use (U) — For the purposes of this proposal, all 22 264 substances on the DSL were ranked in 

descending order on the basis of their sums of normalized indices of expert-ranked functional 

use and industrial sector codes for each substance. Development of the parameter related to use 

(U) relied principally on expert judgement. Individually, 33 experts were asked to rank each of 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

25

the functional use and industrial sector codes as having “high,” “medium” or “low” potential for 

exposure. An expert-ranked index was subsequently developed for each of the functional use and 

industrial sector codes through summation of the number of experts reporting each of “low,” 

“medium” and “high” potential for exposure multiplied by scaling factors of 1 for “low,” 10 for 

“medium” and 100 for “high.” This index was then normalized to a scale between 1 and 100 by 

dividing by the number of participants. The order-of-magnitude scaling factors, although 

principally arbitrary, were chosen to increase the spread of values for the indices of use and to 

bias the weighting to those uses considered by experts to have the greatest potential for 

exposure. The manner in which the use codes were ranked on the basis of the output of the two 

workshops of experts is presented in Appendix C. 

Use codes — “Functional use” and “industrial sector” codes were established by Environment 

Canada to provide information on type of use and industrial sector usage for particular 

substances as part of the compilation of the DSL (Environment Canada, 1988). Individual 

submitters were required to use these codes in their submissions. Ninety-nine codes were 

established for DSL reporting, with three types of code: special use codes (codes 00 and 01), 

functional use codes (codes 02 to 51) and industrial sector codes (codes 52 to 98). A list of the 

functional use and industrial sector codes is included in Appendix B. 

 

U.S. EPA HPV Challenge Program List — The U.S. HPV chemicals are those that are 

manufactured in or imported into the United States in amounts equal to or greater than one 

million pounds per year. The U.S. EPA HPV Challenge Program List consists of all the HPV 

chemicals (approximately 2780) reported during the Toxic Substances Control Act (TSCA) 1990 

Inventory Update Rule (IUR) reporting year and is available from 

<http://www.epa.gov/chemrtk/volchall.htm>. Inorganic substances and polymers, except in 

special circumstances, were not subject to the IUR reporting requirements. 

UVCBs — Substances of Unknown or Variable composition, Complex reaction products and 

Biological materials are substances that cannot be represented by a complete structure diagram 

and specific molecular formula and include materials derived from natural sources and complex 

reactions that cannot be characterized in terms of constituent chemical compounds because their 

composition is too complex or variable. 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

26

8. References 

Environment Canada. 1988. Reporting for the Domestic Substances List. Ministry of Supply and 

Services Canada (DSS Catalogue No. En40-364/1988). 

European Commission. 2003. The New Chemicals Legislation – REACH. May 7, 2003. 

Available from the European Commission web site: 

<http://europa.eu.int/comm/enterprise/chemicals/chempol/whitepaper/reach.htm>. 

Government of Canada. 1994. New Substances Notification Regulations. SOR/94-260. Text 

available from the Department of Justice web site: <http://laws.justice.gc.ca/en/C-15.31/SOR94-260/index.html>. 

Government of Canada. 1999. Canadian Environmental Protection Act, 1999. Canada Gazette 

Part III, November 4, 1999, 22(3). 

Government of Canada. 2001a. Notice with Respect to Certain Substances on the Domestic 

Substances List (DSL). Canada Gazette Part I, November 17, 2001, 135(46): 4194–4210. 

Government of Canada. 2001b. Guidelines for the Notification and Testing of New Substances: 

Chemicals and Polymers. Pursuant to The New Substances Notification Regulations of the 

Canadian Environmental Protection Act, 1999. August 2001. Available from the Environment 

Canada New Substances Program web site: 

<http://www.ec.gc.ca/substances/nsb/eng/gui_e.htm>. 

Koniecki D, Newhook R, Long G, Conilh de Beyssac B, and Socha A. 1997. Screening 

candidate substances for the second Priority Substances List under the Canadian Environmental 

Protection Act. Environmental Carcinogenesis & Ecotoxicology Reviews, C15(1): 41–59. 

OECD. 2003. Manual for the Investigation of HPV Chemicals. OECD Secretariat. April 2003. 

Available from the OECD web site: 

<http://www.oecd.org/document/7/0,2340,en_2649_34379_1947463_1_1_1_1,00.html>. 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

27

Appendix A: Substances Initially Prioritized by the Proposed Approach 

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

INORGANICS 

124-38-9 Carbon dioxide Carbon Yes 

143-33-9 Sodium cyanide (NaCN) Cyanides Yes 

144-55-8 Carbonic acid, monosodium 

salt 

Carbonates Yes 

298-14-6 Carbonic acid, 

monopotassium salt 

Carbonates Yes 

409-21-2 Silicon carbide (SiC) Silicon 

471-34-1 Carbonic acid, calcium salt 

(1:1) 

Carbonates 

497-19-8 Carbonic acid, disodium salt Carbonates Yes 

513-77-9 Carbonic acid, barium salt 

(1:1) 

Barium Yes 

533-96-0 Carbonic acid, sodium salt 

(2:3) 

Carbonates 

546-93-0 Carbonic acid, magnesium 

salt (1:1) 

Carbonates Yes 

630-08-0 Carbon monoxide Carbon Yes Yes 

1066-33-7 Carbonic acid, 

monoammonium salt 

Carbonates Yes 

1302-42-7 Aluminate (AlO2

-

), sodium Aluminum Yes 

1302-76-7 Kyanite (Al2O(SiO4)) Aluminum 

1303-96-4 Borax (B4Na2O7·10H2O) Boron 

1305-62-0 Calcium hydroxide 

(Ca(OH)2) 

Hydroxides/ 

oxides 

 Yes 

1305-78-8 Calcium oxide (CaO) Hydroxides/ 

oxides 

 Yes 

1308-38-9 Chromium oxide (Cr2O3) Chromium Yes 

1309-37-1 Iron oxide (Fe2O3) Iron Yes 

1309-38-2 Magnetite (Fe3O4) Iron Yes 

1309-42-8 Magnesium hydroxide 

(Mg(OH)2) 

Hydroxides/ 

oxides 

 Yes 

1309-48-4 Magnesium oxide (MgO) Hydroxides/ 

oxides 

 Yes 

1309-60-0 Lead oxide (PbO2) Lead 

1309-64-4 Antimony oxide (Sb2O3) Antimony 

1310-58-3 Potassium hydroxide (KOH) Hydroxides/ 

oxides 

 Yes 

1310-73-2 Sodium hydroxide (NaOH) Hydroxides/ 

oxides 

 Yes 

1313-13-9 Manganese oxide (MnO2) Manganese 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

28

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

1313-82-2 Sodium sulfide (Na2S) Sulfur compounds Yes 

1313-99-1 Nickel oxide (NiO) Nickel Yes Yes 

1314-13-2 Zinc oxide (ZnO) Zinc 

1314-23-4 Zirconium oxide (ZrO2) Zirconium 

1314-41-6 Lead oxide (Pb3O4) Lead Yes 

1314-56-3 Phosphorus oxide (P2O5) Phosphorus Yes 

1314-62-1 Vanadium oxide (V2O5) Vanadium 

1317-36-8 Lead oxide (PbO) Lead Yes 

1317-38-0 Copper oxide (CuO) Copper Yes 

1317-39-1 Copper oxide (Cu2O) Copper Yes 

1317-61-9 Iron oxide (Fe3O4) Iron Yes 

1317-80-2 Rutile (TiO2) Titanium 

1330-43-4 Boron sodium oxide 

(B4Na2O7) 

Boron 

1333-74-0 Hydrogen Miscellaneous Yes 

1333-82-0 Chromium oxide (CrO3) Chromium Yes 

1336-21-6 Ammonium hydroxide 

(NH4OH) 

Hydroxides/ 

oxides 

 Yes 

1341-49-7 Ammonium fluoride 

(NH4(HF2)) 

Fluoro 

compounds 

Yes Yes 

1344-28-1 Aluminum oxide (Al2O3) Aluminum Yes 

1344-43-0 Manganese oxide (MnO) Manganese 

5329-14-6 Sulfamic acid Sulfur compounds Yes 

6484-52-2 Nitric acid, ammonium salt Nitrates/ 

nitrites 

 Yes 

6834-92-0 Silicic acid (H2SiO3), 

disodium salt 

Silicon Yes 

7320-34-5 Diphosphoric acid, 

tetrapotassium salt 

Phosphorus 

7429-90-5 Aluminum Aluminum 

7439-89-6 Iron Iron 

7439-92-1 Lead Lead 

7439-96-5 Manganese Manganese 

7440-02-0 Nickel Nickel Yes 

7440-21-3 Silicon Silicon 

7440-22-4 Silver Silver 

7440-31-5 Tin Tin 

7440-44-0 Carbon Carbon Yes 

7440-47-3 Chromium Chromium 

7440-48-4 Cobalt Cobalt 

7440-50-8 Copper Copper 

7440-66-6 Zinc Zinc 

7446-09-5 Sulfur dioxide Sulfur compounds Yes 

7446-70-0 Aluminum chloride (AlCl3) Aluminum Yes Yes 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

29

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

7447-40-7 Potassium chloride (KCl) Chlorine 

compounds 

 Yes 

7487-88-9 Sulfuric acid, magnesium 

salt (1:1) 

Sulfur compounds 

7553-56-2 Iodine Iodine compounds 

7558-79-4 Phosphoric acid, disodium 

salt 

Phosphorus 

7558-80-7 Phosphoric acid, 

monosodium salt 

Phosphorus 

7601-54-9 Phosphoric acid, trisodium 

salt 

Phosphorus 

7631-86-9 Silica Silicon Yes 

7631-90-5 Sulfurous acid, monosodium 

salt 

Sulfur compounds Yes 

7631-99-4 Nitric acid, sodium salt Nitrates/ 

nitrites 

 Yes 

7632-00-0 Nitrous acid, sodium salt Nitrates/ 

nitrites 

 Yes 

7632-04-4 Perboric acid (HBO(O2)), 

sodium salt 

Boron 

7646-85-7 Zinc chloride (ZnCl2) Zinc 

7647-01-0 Hydrochloric acid Chlorine 

compounds 

 Yes HC 

7647-14-5 Sodium chloride (NaCl) Chlorine 

compounds 

 

7664-38-2 Phosphoric acid Phosphorus 

7664-39-3 Hydrofluoric acid Fluoro 

compounds 

Yes 

7664-41-7 Ammonia Basic compounds Yes Yes 

7664-93-9 Sulfuric acid Sulfur compounds Yes HC 

7681-11-0 Potassium iodide (KI) Iodine compounds 

7681-38-1 Sulfuric acid, monosodium 

salt 

Sulfur compounds Yes 

7681-49-4 Sodium fluoride (NaF) Fluoro 

compounds 

Yes Yes 

7681-52-9 Hypochlorous acid, sodium 

salt 

Chlorine 

compounds 

 Yes 

7681-57-4 Disulfurous acid, disodium 

salt 

Sulfur compounds Yes 

7697-37-2 Nitric acid Nitrates/ 

nitrites 

 Yes 

7704-34-9 Sulfur Sulfur compounds Yes 

7705-08-0 Iron chloride (FeCl3) Iron Yes 

7720-78-7 Sulfuric acid, iron(2+) salt 

(1:1) 

Iron Yes 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

30

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

7722-76-1 Phosphoric acid, 

monoammonium salt 

Phosphorus 

7722-84-1 Hydrogen peroxide (H2O2) Peroxo 

compounds 

 

7722-88-5 Diphosphoric acid, 

tetrasodium salt 

Phosphorus 

7727-37-9 Nitrogen Miscellaneous 

7727-43-7 Sulfuric acid, barium salt 

(1:1) 

Barium Yes 

7732-18-5 Water Miscellaneous 

7733-02-0 Sulfuric acid, zinc salt (1:1) Zinc 

7738-94-5 Chromic acid (H2CrO4) Chromium(VI) Yes 

7757-79-1 Nitric acid, potassium salt Nitrates/ 

nitrites 

 Yes 

7757-82-6 Sulfuric acid, disodium salt Sulfur compounds Yes 

7757-83-7 Sulfurous acid, disodium salt Sulfur compounds Yes 

7757-93-9 Phosphoric acid, calcium salt 

(1:1) 

Phosphorus 

7758-11-4 Phosphoric acid, 

dipotassium salt 

Phosphorus 

7758-16-9 Diphosphoric acid, disodium 

salt 

Phosphorus 

7758-23-8 Phosphoric acid, calcium salt 

(2:1) 

Phosphorus Yes 

7758-29-4 Triphosphoric acid, 

pentasodium salt 

Phosphorus 

7758-87-4 Phosphoric acid, calcium salt 

(2:3) 

Phosphorus 

7758-97-6 Chromic acid (H2CrO4), 

lead(2+) salt (1:1) 

Chromium(VI) Yes Yes 

7758-98-7 Sulfuric acid, copper(2+) 

salt (1:1) 

Copper Yes 

7775-09-9 Chloric acid, sodium salt Chlorine 

compounds 

 Yes 

7775-14-6 Dithionous acid, disodium 

salt 

Sulfur compounds Yes 

7778-18-9 Sulfuric acid, calcium salt 

(1:1) 

Sulfur compounds Yes 

7778-54-3 Hypochlorous acid, calcium 

salt 

Chlorine 

compounds 

 Yes 

7778-80-5 Sulfuric acid, dipotassium 

salt 

Sulfur compounds Yes 

7782-42-5 Graphite Carbon 

7782-50-5 Chlorine Chlorine 

compounds 

 Yes 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

31

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

7783-20-2 Sulfuric acid, diammonium 

salt 

Sulfur compounds Yes 

7783-28-0 Phosphoric acid, 

diammonium salt 

Phosphorus 

7785-88-8 Phosphoric acid, aluminum 

sodium salt 

Phosphorus 

7786-30-3 Magnesium chloride 

(MgCl2) 

Chlorine 

compounds 

 

7786-81-4 Sulfuric acid, nickel(2+) salt 

(1:1) 

Nickel 

10028-22-5 Sulfuric acid, iron(3+) salt 

(3:2) 

Iron Yes 

10043-01-3 Sulfuric acid, aluminum salt 

(3:2) 

Aluminum Yes Yes 

10043-35-3 Boric acid (H3BO3) Boron 

10043-52-4 Calcium chloride (CaCl2) Chlorine 

compounds 

 Yes 

10049-04-4 Chlorine oxide (ClO2) Chlorine 

compounds 

 HC 

10101-39-0 Silicic acid (H2SiO3), 

calcium salt (1:1) 

Silicon Yes 

10101-52-7 Silicic acid (H4SiO4), 

zirconium(4+) salt (1:1) 

Silicon 

10124-37-5 Nitric acid, calcium salt Nitrates/ 

nitrites 

 

10124-43-3 Sulfuric acid, cobalt(2+) salt 

(1:1) 

Cobalt Yes 

10192-30-0 Sulfurous acid, 

monoammonium salt 

Sulfur compounds 

10361-37-2 Barium chloride (BaCl2) Barium 

10588-01-9 Chromic acid (H2Cr2O7), 

disodium salt 

Chromium(VI) Yes 

12125-02-9 Ammonium chloride 

(NH4Cl) 

Chlorine 

compounds 

 Yes 

12136-45-7 Potassium oxide (K2O) Hydroxides/ 

oxides 

 

12202-17-4 Lead oxide sulfate 

(Pb4O3(SO4)) 

Lead Yes 

13463-67-7 Titanium oxide (TiO2) Titanium 

13530-65-9 Chromic acid (H2CrO4), zinc 

salt (1:1) 

Chromium(VI) Yes 

13601-19-9 Ferrate(4-), hexakis(cyanoC)-, tetrasodium, (OC-6-11)- Ferrocyanides 

14464-46-1 Cristobalite (SiO2) Silicon 

14807-96-6 Talc (Mg3H2(SiO3)4) Silicon 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

32

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

14808-60-7 Quartz (SiO2) Silicon 

16721-80-5 Sodium sulfide (NaSH) Sulfur compounds Yes 

16893-85-9 Silicate(2-), hexafluoro-, 

disodium 

Silicon Yes 

17194-00-2 Barium hydroxide 

(Ba(OH)2) 

Barium 

21645-51-2 Aluminum hydroxide 

(Al(OH)3) 

Aluminum Yes 

60676-86-0 Silica, vitreous Silicon 

ORGANICS 

50-00-0 Formaldehyde Aldehydes Yes Yes Yes 

50-21-5 Propanoic acid, 2-hydroxy- Acids Yes 

50-70-4 D-Glucitol Carbohydrates & 

derivatives 

 Yes 

50-81-7 L-Ascorbic acid Lactones Yes 

50-99-7 D-Glucose Carbohydrates & 

derivatives 

 Yes 

56-23-5 Methane, tetrachloro- Halogenated, 

aliphatic 

Yes Yes Yes 

56-81-5 1,2,3-Propanetriol Alcohols Yes Yes 

56-87-1 L-Lysine Amino acids & 

derivatives 

 

57-10-3 Hexadecanoic acid Acids Yes Yes 

57-11-4 Octadecanoic acid Acids Yes Yes 

57-13-6 Urea Ureas Yes 

57-50-1 α-D-Glucopyranoside, β-Dfructofuranosyl Carbohydrates & 

derivatives 

 Yes 

57-55-6 1,2-Propanediol Alcohols Yes Yes 

59-51-8 DL-Methionine Amino acids & 

derivatives 

 

60-00-4 Glycine, N,N'-1,2-

ethanediylbis[N-

(carboxymethyl)]- 

Amines, aliphatic Yes 

60-24-2 Ethanol, 2-mercapto- Thiols Yes Yes 

60-29-7 Ethane, 1,1'-oxybis- Ethers Yes Yes 

60-33-3 9,12-Octadecadienoic acid, 

(Z,Z)- 

Acids Yes Yes 

62-56-6 Thiourea Ureas Yes Yes 

63-42-3 D-Glucose, 4-O-β-DgalactopyranosylCarbohydrates & 

derivatives 

 

64-02-8 Glycine, N,N'-1,2-

ethanediylbis[N-

(carboxymethyl)]-, 

tetrasodium salt 

Amines, aliphatic Yes 

64-17-5 Ethanol Alcohols Yes Yes 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

33

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

64-18-6 Formic acid Acids Yes Yes 

64-19-7 Acetic acid Acids Yes Yes 

65-85-0 Benzoic acid Acids Yes Yes 

67-56-1 Methanol Alcohols Yes Yes HC 

67-63-0 2-Propanol Alcohols Yes HC 

67-64-1 2-Propanone Ketones Yes HC 

67-66-3 Methane, trichloro- Halogenated, 

aliphatic 

 Yes Yes 

68-04-2 1,2,3-Propanetricarboxylic 

acid, 2-hydroxy-, trisodium 

salt 

Acid salts Yes Yes 

68-12-2 Formamide, N,N-dimethyl- Amides Yes Yes Yes 

69-65-8 D-Mannitol Carbohydrates & 

derivatives 

 Yes 

69-72-7 Benzoic acid, 2-hydroxy- Phenols Yes Yes 

71-23-8 1-Propanol Alcohols Yes 

71-36-3 1-Butanol Alcohols Yes Yes HC 

71-41-0 1-Pentanol Alcohols Yes Yes 

71-43-2 Benzene Hydrocarbons, 

aromatic 

Yes Yes Yes 

71-55-6 Ethane, 1,1,1-trichloro- Halogenated, 

aliphatic 

Yes Yes Yes Yes 

74-82-8 Methane Hydrocarbons, 

aliphatic 

 Yes Yes 

74-84-0 Ethane Hydrocarbons, 

aliphatic 

 Yes Yes 

74-87-3 Methane, chloro- Halogenated, 

aliphatic 

 Yes Yes 

74-98-6 Propane Hydrocarbons, 

aliphatic 

 Yes Yes 

75-05-8 Acetonitrile Nitriles Yes 

75-07-0 Acetaldehyde Aldehydes Yes Yes Yes Yes 

75-08-1 Ethanethiol Thiols Yes Yes 

75-09-2 Methane, dichloro- Halogenated, 

aliphatic 

Yes Yes Yes Yes 

75-21-8 Oxirane Epoxides Yes Yes Yes 

75-28-5 Propane, 2-methyl- Hydrocarbons, 

aliphatic 

 Yes Yes 

75-56-9 Oxirane, methyl- Epoxides Yes 

75-66-1 2-Propanethiol, 2-methyl- Thiols Yes Yes 

75-69-4 Methane, trichlorofluoro- Halogenated, 

aliphatic 

Yes Yes 

75-71-8 Methane, dichlorodifluoro- Halogenated, 

aliphatic 

Yes Yes 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

34

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

76-13-1 Ethane, 1,1,2-trichloro-1,2,2-

trifluoroHalogenated, aliphatic 

Yes Yes 

77-73-6 4,7-Methano-1H-indene, 

3a,4,7,7a-tetrahydroHydrocarbons, aliphatic 

 Yes 

77-92-9 1,2,3-Propanetricarboxylic 

acid, 2-hydroxyAcids Yes Yes 

77-99-6 1,3-Propanediol, 2-ethyl-2-

(hydroxymethyl)- 

Alcohols Yes 

78-51-3 Ethanol, 2-butoxy-, 

phosphate (3:1) 

Phosphorus(V) Yes Yes 

78-59-1 2-Cyclohexen-1-one, 3,5,5-

trimethylKetones Yes Yes 

78-78-4 Butane, 2-methyl- Hydrocarbons, 

aliphatic 

 Yes Yes 

78-79-5 1,3-Butadiene, 2-methyl- Hydrocarbons, 

aliphatic 

 Yes Yes 

78-83-1 1-Propanol, 2-methyl- Alcohols Yes Yes 

78-93-3 2-Butanone Ketones Yes HC 

79-01-6 Ethene, trichloro- Halogenated, 

aliphatic 

Yes Yes Yes 

79-06-1 2-Propenamide Acrylamides Yes 

79-09-4 Propanoic acid Acids Yes Yes 

79-10-7 2-Propenoic acid Acrylates Yes 

79-14-1 Acetic acid, hydroxy- Acids Yes Yes 

79-41-4 2-Propenoic acid, 2-methyl- Methacrylates Yes 

80-05-7 Phenol, 4,4'-(1-

methylethylidene)bisPhenols Yes 

80-15-9 Hydroperoxide, 1-methyl-1-

phenylethyl 

Peroxo 

compounds 

 Yes Yes 

80-43-3 Peroxide, bis(1-methyl-1-

phenylethyl) 

Peroxo 

compounds 

 Yes Yes 

80-62-6 2-Propenoic acid, 2-methyl-, 

methyl ester 

Methacrylates Yes Yes 

84-74-2 1,2-Benzenedicarboxylic 

acid, dibutyl ester 

Phthalates Yes Yes 

85-44-9 1,3-Isobenzofurandione Phthalates Yes Yes 

85-68-7 1,2-Benzenedicarboxylic 

acid, butyl phenylmethyl 

ester 

Phthalates Yes Yes 

87-90-1 1,3,5-Triazine2,4,6(1H,3H,5H)-trione, 

1,3,5-trichloroTriazines Yes Yes 

90-30-2 1-Naphthalenamine, NphenylAmines, aromatic Yes 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

35

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

91-20-3 Naphthalene Hydrocarbons, 

polycyclic 

aromatic 

Yes Yes HC 

91-44-1 2H-1-Benzopyran-2-one, 7-

(diethylamino)-4-methylLactones 

93-58-3 Benzoic acid, methyl ester Esters, aromatic Yes 

94-91-7 Phenol, 2,2'-[(1-methyl-1,2-

ethanediyl)bis-

(nitrilomethylidyne)]bisPhenols 

95-47-6 Benzene, 1,2-dimethyl- Hydrocarbons, 

aromatic 

 Yes Yes 

96-29-7 2-Butanone, oxime Ketoximes Yes Yes 

97-53-0 Phenol, 2-methoxy-4-(2-

propenyl)- 

Phenols 

97-88-1 2-Propenoic acid, 2-methyl-, 

butyl ester 

Methacrylates Yes Yes 

98-00-0 2-Furanmethanol Ethers, aromatic Yes Yes 

98-01-1 2-Furancarboxaldehyde Ethers, aromatic Yes 

98-82-8 Benzene, (1-methylethyl)- Hydrocarbons, 

aromatic 

 Yes 

98-92-0 3-Pyridinecarboxamide N-Heterocycles Yes Yes 

100-37-8 Ethanol, 2-(diethylamino)- Alcohols Yes Yes 

100-41-4 Benzene, ethyl- Hydrocarbons, 

aromatic 

 Yes HC 

100-42-5 Benzene, ethenyl- Hydrocarbons, 

aromatic 

 Yes Yes 

100-44-7 Benzene, (chloromethyl)- Halogenated, 

aliphatic 

 Yes 

100-51-6 Benzenemethanol Alcohols Yes Yes 

100-52-7 Benzaldehyde Aldehydes Yes 

100-97-0 1,3,5,7-Tetraazatricyclo[3.3.1.13,7]decane Triazines Yes 

101-68-8 Benzene, 1,1'-methylenebis[4-isocyanatoIsocyanates Yes 

101-81-5 Benzene, 1,1'-methylenebis- Hydrocarbons, 

aromatic 

 Yes 

101-96-2 1,4-Benzenediamine, N,N'-

bis(1-methylpropyl)- 

Amines, aromatic Yes 

102-71-6 Ethanol, 2,2',2"-nitrilotris- Alcohols Yes 

102-76-1 1,2,3-Propanetriol, triacetate Esters Yes Yes 

103-11-7 2-Propenoic acid, 2-

ethylhexyl ester 

Acrylates Yes 

103-23-1 Hexanedioic acid, bis(2-

ethylhexyl) ester 

Esters Yes 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

36

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

103-24-2 Nonanedioic acid, bis(2-

ethylhexyl) ester 

Esters Yes 

104-15-4 Benzenesulfonic acid, 4-

methylBenzenesulfonates 

 Yes Yes 

104-76-7 1-Hexanol, 2-ethyl- Alcohols Yes 

105-59-9 Ethanol, 2,2'-

(methylimino)bisAlcohols Yes Yes 

105-60-2 2H-Azepin-2-one, 

hexahydroN-Heterocycles Yes Yes 

106-89-8 Oxirane, chloromethyl- Epoxides Yes Yes 

106-97-8 Butane Hydrocarbons, 

aliphatic 

 Yes Yes 

106-99-0 1,3-Butadiene Hydrocarbons, 

aliphatic 

Yes Yes Yes 

107-06-2 Ethane, 1,2-dichloro- Halogenated, 

aliphatic 

Yes Yes Yes Yes 

107-13-1 2-Propenenitrile Nitriles Yes Yes Yes 

107-15-3 1,2-Ethanediamine Amines, aliphatic Yes Yes 

107-21-1 1,2-Ethanediol Alcohols Yes Yes Yes 

107-41-5 2,4-Pentanediol, 2-methyl- Alcohols Yes Yes 

107-83-5 Pentane, 2-methyl- Hydrocarbons, 

aliphatic 

 Yes Yes 

107-87-9 2-Pentanone Ketones Yes 

107-92-6 Butanoic acid Acids Yes Yes 

107-98-2 2-Propanol, 1-methoxy- Glycol ethers Yes Yes 

108-05-4 Acetic acid, ethenyl ester Esters Yes 

108-10-1 2-Pentanone, 4-methyl- Ketones Yes HC 

108-11-2 2-Pentanol, 4-methyl- Alcohols Yes Yes 

108-21-4 Acetic acid, 1-methylethyl 

ester 

Esters Yes Yes 

108-24-7 Acetic acid, anhydride Acid anhydrides Yes 

108-31-6 2,5-Furandione Acid anhydrides Yes Yes 

108-38-3 Benzene, 1,3-dimethyl- Hydrocarbons, 

aromatic 

 Yes Yes 

108-46-3 1,3-Benzenediol Phenols Yes Yes 

108-65-6 2-Propanol, 1-methoxy-, 

acetate 

Glycol ethers Yes Yes 

108-78-1 1,3,5-Triazine-2,4,6-triamine Triazines Yes 

108-83-8 4-Heptanone, 2,6-dimethyl- Ketones Yes 

108-88-3 Benzene, methyl- Hydrocarbons, 

aromatic 

 Yes Yes 

108-91-8 Cyclohexanamine Amines, aliphatic Yes Yes 

108-93-0 Cyclohexanol Alcohols Yes Yes 

108-94-1 Cyclohexanone Ketones Yes 

108-95-2 Phenol Phenols Yes Yes 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

37

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

109-60-4 Acetic acid, propyl ester Esters Yes Yes 

109-66-0 Pentane Hydrocarbons, 

aliphatic 

 Yes 

109-86-4 Ethanol, 2-methoxy- Glycol ethers Yes Yes Yes 

109-94-4 Formic acid, ethyl ester Esters 

109-99-9 Furan, tetrahydro- Ethers Yes 

110-12-3 2-Hexanone, 5-methyl- Ketones Yes Yes 

110-15-6 Butanedioic acid Acids Yes Yes 

110-17-8 2-Butenedioic acid (E)- Acids Yes Yes 

110-19-0 Acetic acid, 2-methylpropyl 

ester 

Esters Yes Yes 

110-30-5 Octadecanamide, N,N'-1,2-

ethanediylbisAmides Yes Yes 

110-43-0 2-Heptanone Ketones Yes 

110-54-3 Hexane Hydrocarbons, 

aliphatic 

 Yes Yes 

110-80-5 Ethanol, 2-ethoxy- Glycol ethers Yes Yes 

110-82-7 Cyclohexane Hydrocarbons, 

aliphatic 

 Yes HC 

110-91-8 Morpholine N,O-Heterocycles Yes Yes 

110-97-4 2-Propanol, 1,1'-iminobis- Alcohols Yes Yes 

111-15-9 Ethanol, 2-ethoxy-, acetate Glycol ethers Yes 

111-27-3 1-Hexanol Alcohols Yes Yes 

111-40-0 1,2-Ethanediamine, N-(2-

aminoethyl)- 

Amines, aliphatic Yes 

111-42-2 Ethanol, 2,2'-iminobis- Alcohols Yes HC 

111-46-6 Ethanol, 2,2'-oxybis- Glycol ethers Yes Yes HC 

111-55-7 1,2-Ethanediol, diacetate Esters Yes 

111-76-2 Ethanol, 2-butoxy- Glycol ethers Yes Yes 

111-77-3 Ethanol, 2-(2-

methoxyethoxy)- 

Glycol ethers Yes 

111-82-0 Dodecanoic acid, methyl 

ester 

Esters Yes Yes 

111-87-5 1-Octanol Alcohols Yes Yes 

111-90-0 Ethanol, 2-(2-ethoxyethoxy)- Glycol ethers Yes Yes 

112-05-0 Nonanoic acid Acids Yes Yes 

112-07-2 Ethanol, 2-butoxy-, acetate Glycol ethers Yes Yes 

112-27-6 Ethanol, 2,2'-[1,2-

ethanediylbis(oxy)]bisGlycol ethers Yes Yes 

112-30-1 1-Decanol Alcohols Yes Yes 

112-31-2 Decanal Aldehydes 

112-34-5 Ethanol, 2-(2-

butoxyethoxy)- 

Glycol ethers Yes 

112-38-9 10-Undecenoic acid Acids 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

38

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

112-53-8 1-Dodecanol Alcohols Yes 

112-54-9 Dodecanal Aldehydes 

112-60-7 Ethanol, 2,2'-[oxybis(2,1-

ethanediyloxy)]bisGlycol ethers Yes Yes 

112-69-6 1-Hexadecanamine, N,NdimethylAmines, aliphatic Yes Yes 

112-72-1 1-Tetradecanol Alcohols Yes Yes 

112-80-1 9-Octadecenoic acid, (Z)- Acids Yes Yes 

112-84-5 13-Docosenamide, (Z)- Amides Yes Yes 

112-90-3 9-Octadecen-1-amine, (Z)- Amines, aliphatic Yes Yes 

112-92-5 1-Octadecanol Alcohols Yes 

115-07-1 1-Propene Hydrocarbons, 

aliphatic 

 Yes Yes HC 

115-77-5 1,3-Propanediol, 2,2-

bis(hydroxymethyl)- 

Alcohols Yes 

117-81-7 1,2-Benzenedicarboxylic 

acid, bis(2-ethylhexyl) ester 

Phthalates Yes Yes Yes 

120-40-1 Dodecanamide, N,N-bis(2-

hydroxyethyl)- 

Amides Yes 

120-51-4 Benzoic acid, phenylmethyl 

ester 

Esters Yes Yes 

120-55-8 Ethanol, 2,2'-oxybis-, 

dibenzoate 

Glycol ethers Yes 

121-91-5 1,3-Benzenedicarboxylic 

acid 

Acids Yes Yes 

122-39-4 Benzenamine, N-phenyl- Amines, aromatic Yes 

122-78-1 Benzeneacetaldehyde Aldehydes 

122-97-4 Benzenepropanol Alcohols 

122-99-6 Ethanol, 2-phenoxy- Alcohols Yes Yes 

123-31-9 1,4-Benzenediol Phenols Yes 

123-42-2 2-Pentanone, 4-hydroxy-4-

methylKetones Yes 

123-77-3 Diazenedicarboxamide Amides Yes 

123-86-4 Acetic acid, butyl ester Esters Yes Yes 

123-91-1 1,4-Dioxane Ethers Yes 

124-04-9 Hexanedioic acid Acids Yes Yes 

124-07-2 Octanoic acid Acids Yes Yes 

124-13-0 Octanal Aldehydes Yes 

124-19-6 Nonanal Aldehydes Yes 

124-30-1 1-Octadecanamine Amines, aliphatic Yes Yes 

124-40-3 Methanamine, N-methyl- Amines, aliphatic Yes Yes 

124-68-5 1-Propanol, 2-amino-2-

methylAlcohols Yes Yes 

126-30-7 1,3-Propanediol, 2,2-

dimethylAlcohols Yes 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

39

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

126-86-3 5-Decyne-4,7-diol, 2,4,7,9-

tetramethylAlcohols Yes 

127-08-2 Acetic acid, potassium salt Acid salts Yes Yes 

127-09-3 Acetic acid, sodium salt Acid salts Yes Yes 

127-18-4 Ethene, tetrachloro- Halogenated, 

aliphatic 

Yes Yes Yes 

128-37-0 Phenol, 2,6-bis(1,1-

dimethylethyl)-4-methylPhenols Yes Yes 

128-39-2 Phenol, 2,6-bis(1,1-

dimethylethyl)- 

Phenols Yes 

136-51-6 Hexanoic acid, 2-ethyl-, 

calcium salt 

Acid salts Yes Yes 

136-60-7 Benzoic acid, butyl ester Esters 

137-08-6 β-Alanine, N-(2,4-

dihydroxy-3,3-dimethyl-1-

oxobutyl)-, calcium salt 

(2:1), (R)- 

Amino acids & 

derivatives 

 

137-16-6 Glycine, N-methyl-N-(1-

oxododecyl)-, sodium salt 

Amino acids & 

derivatives 

 Yes 

139-05-9 Sulfamic acid, cyclohexyl-, 

monosodium salt 

Sulfur compounds 

139-96-8 Sulfuric acid, monododecyl 

ester, compd. with 2,2',2"-

nitrilotris[ethanol] (1:1) 

Sulfur compounds Yes Yes 

140-01-2 Glycine, N,N-bis[2-

[bis(carboxymethyl)-

amino]ethyl]-, pentasodium 

salt 

Amino acids & 

derivatives 

 Yes Yes 

140-88-5 2-Propenoic acid, ethyl ester Acrylates Yes Yes 

141-22-0 9-Octadecenoic acid, 12-

hydroxy-, [R-(Z)]- 

Acids 

141-32-2 2-Propenoic acid, butyl ester Acrylates Yes Yes 

141-43-5 Ethanol, 2-amino- Alcohols Yes Yes 

141-53-7 Formic acid, sodium salt Acid salts Yes Yes 

141-78-6 Acetic acid, ethyl ester Esters Yes Yes 

141-79-7 3-Penten-2-one, 4-methyl- Ketones Yes 

142-47-2 L-Glutamic acid, 

monosodium salt 

Amino acids & 

derivatives 

 Yes Yes 

142-78-9 Dodecanamide, N-(2-

hydroxyethyl)- 

Amides Yes Yes 

142-82-5 Heptane Hydrocarbons, 

aliphatic 

 Yes Yes 

143-07-7 Dodecanoic acid Acids Yes Yes 

143-08-8 1-Nonanol Alcohols 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

40

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

143-19-1 9-Octadecenoic acid, (Z)-, 

sodium salt 

Acid salts 

144-62-7 Ethanedioic acid Acids Yes Yes 

149-30-4 2(3H)-Benzothiazolethione N,S-Heterocycles Yes Yes 

149-57-5 Hexanoic acid, 2-ethyl- Acids Yes 

151-21-3 Sulfuric acid, monododecyl 

ester, sodium salt 

Sulfur compounds Yes 

301-02-0 9-Octadecenamide, (Z)- Amides Yes Yes 

334-48-5 Decanoic acid Acids Yes Yes 

431-03-8 2,3-Butanedione Ketones 

461-58-5 Guanidine, cyano- Amines, aliphatic Yes Yes 

463-40-1 9,12,15-Octadecatrienoic 

acid, (Z,Z,Z)- 

Acids 

513-86-0 2-Butanone, 3-hydroxy- Ketones 

514-10-3 1-Phenanthrenecarboxylic 

acid, 

1,2,3,4,4a,4b,5,6,10,10adecahydro-1,4a-dimethyl-7-

(1-methylethyl)-, [1R-

(1α,4aβ ,4bα,10aα)]- 

Acids 

526-95-4 D-Gluconic acid Carbohydrates & 

derivatives 

 Yes Yes 

527-07-1 D-Gluconic acid, 

monosodium salt 

Carbohydrates & 

derivatives 

 Yes Yes 

532-32-1 Benzoic acid, sodium salt Acid salts Yes Yes 

540-84-1 Pentane, 2,2,4-trimethyl- Hydrocarbons, 

aliphatic 

 Yes Yes 

544-17-2 Formic acid, calcium salt Acid salts Yes Yes 

544-63-8 Tetradecanoic acid Acids Yes Yes 

552-30-7 5-Isobenzofurancarboxylic 

acid, 1,3-dihydro-1,3-dioxoAcid anhydrides Yes Yes 

577-11-7 Butanedioic acid, sulfo-, 1,4-

bis(2-ethylhexyl) ester, 

sodium salt 

Sulfur compounds Yes Yes 

584-08-7 Carbonic acid, dipotassium 

salt 

Isocyanates Yes 

587-98-4 Benzenesulfonic acid, 3-[[4-

(phenylamino)phenyl]azo]-, 

monosodium salt 

Azo compounds 

628-63-7 Acetic acid, pentyl ester Esters Yes Yes 

763-69-9 Propanoic acid, 3-ethoxy-, 

ethyl ester 

Esters Yes Yes 

822-16-2 Octadecanoic acid, sodium 

salt 

Acid salts Yes 

872-50-4 2-Pyrrolidinone, 1-methyl- N-Heterocycles Yes Yes 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

41

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

1119-40-0 Pentanedioic acid, dimethyl 

ester 

Esters Yes Yes 

1120-36-1 1-Tetradecene Hydrocarbons, 

aliphatic 

 Yes 

1300-72-7 Benzenesulfonic acid, 

dimethyl-, sodium salt 

Benzenesulfonates  Yes Yes 

1319-77-3 Phenol, methyl- Phenols Yes Yes 

1321-69-3 Naphthalenesulfonic acid, 

sodium salt 

Naphthalenesulfonates  

1330-20-7 Benzene, dimethyl- Hydrocarbons, 

aromatic 

 Yes Yes Yes 

1330-78-5 Phosphoric acid, 

tris(methylphenyl) ester 

Phosphorus(V) Yes Yes HC 

1331-61-9 Benzenesulfonic acid, 

dodecyl-, ammonium salt 

Benzenesulfonates  Yes 

1334-78-7 Benzaldehyde, methyl- Aldehydes 

1338-41-6 Sorbitan, 

monooctadecanoate 

Esters Yes 

1338-43-8 Sorbitan, mono-9-

octadecenoate, (Z)- 

Esters Yes 

1592-23-0 Octadecanoic acid, calcium 

salt 

Acid salts Yes 

1643-20-5 1-Dodecanamine, N,Ndimethyl-, N-oxide Amine oxides Yes Yes 

1760-24-3 1,2-Ethanediamine, N-[3-

(trimethoxysilyl)propyl]- 

Alkoxysilanes Yes Yes 

2082-79-3 Benzenepropanoic acid, 3,5-

bis(1,1-dimethylethyl)-4-

hydroxy-, octadecyl ester 

Esters Yes Yes 

2235-54-3 Sulfuric acid, monododecyl 

ester, ammonium salt 

Sulfur compounds Yes Yes 

2425-85-6 2-Naphthalenol, 1-[(4-

methyl-2-nitrophenyl)azo]- 

Azo compounds 

2492-26-4 2(3H)-Benzothiazolethione, 

sodium salt 

Benzothiazoles Yes Yes 

2807-30-9 Ethanol, 2-propoxy- Glycol ethers Yes Yes 

2893-78-9 1,3,5-Triazine2,4,6(1H,3H,5H)-trione, 1,3-

dichloro-, sodium salt 

Triazines Yes Yes 

3234-85-3 Tetradecanoic acid, 

tetradecyl ester 

Esters 

3319-31-1 1,2,4-Benzenetricarboxylic 

acid, tris(2-ethylhexyl) ester 

Phthalates Yes Yes 

3648-20-2 1,2-Benzenedicarboxylic 

acid, diundecyl ester 

Phthalates Yes Yes EC 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

42

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

4080-31-3 3,5,7-Triaza-1-azoniatricyclo[3.3.1.13,7]decane, 

1-(3-chloro-2-propenyl)-, 

chloride 

Triazines Yes 

5064-31-3 Glycine, N,Nbis(carboxymethyl)-, 

trisodium salt 

Amino acids & 

derivatives 

 Yes 

5102-83-0 Butanamide, 2,2'-[(3,3'-

dichloro[1,1'-biphenyl]-4,4'-

diyl)bis(azo)]bis[N-(2,4-

dimethylphenyl)-3-oxoDichlorobenzidine-based 

compounds 

 Yes Yes 

5281-04-9 2-Naphthalenecarboxylic 

acid, 3-hydroxy-4-[(4-

methyl-2-sulfophenyl)azo]-, 

calcium salt (1:1) 

Azo -β-naphthols Yes 

5468-75-7 Butanamide, 2,2'-[(3,3'-

dichloro[1,1'-biphenyl]-4,4'-

diyl)bis(azo)]bis[N-(2-

methylphenyl)-3-oxoDichlorobenzidine-based 

compounds 

 Yes 

6358-85-6 Butanamide, 2,2'-[(3,3'-

dichloro[1,1'-biphenyl]-4,4'-

diyl)bis(azo)]bis[3-oxo-NphenylDichlorobenzidine-based 

compounds 

 Yes Yes 

6846-50-0 Propanoic acid, 2-methyl-, 

2,2-dimethyl-1-(1-

methylethyl)-1,3-

propanediyl ester 

Esters Yes 

6915-15-7 Butanedioic acid, hydroxy- Acids Yes Yes 

10081-67-1 Benzenamine, 4-(1-methyl1-phenylethyl)-N-[4-(1-

methyl-1-

phenylethyl)phenyl]- 

Amines, aromatic Yes EC 

12068-03-0 Benzenesulfonic acid, 

methyl-, sodium salt 

Benzenesulfonates  Yes Yes 

13863-31-5 Benzenesulfonic acid, 2,2'-

(1,2-ethenediyl)bis[5-[[4-

[(2-hydroxyethyl)methylamino]-6-(phenylamino)-

1,3,5-triazin-2-yl]amino]-, 

disodium salt

Triazines Yes 

16090-02-1 Benzenesulfonic acid, 2,2'-

(1,2-ethenediyl)bis[5-[[4-(4-

morpholinyl)-6-

(phenylamino)-1,3,5-triazin2-yl]amino]-, disodium salt 

Triazines Yes Yes 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

43

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

17831-71-9 2-Propenoic acid, 

oxybis(2,1-ethanediyloxy2,1-ethanediyl) ester 

Acrylates 

24634-61-5 2,4-Hexadienoic acid, 

potassium salt, (E,E)- 

Acid salts Yes Yes 

25154-52-3 Phenol, nonyl- Phenols Yes 

25155-30-0 Benzenesulfonic acid, 

dodecyl-, sodium salt 

Benzenesulfonates  Yes Yes 

25167-32-2 Benzenesulfonic acid, 

oxybis[dodecyl-, disodium 

salt

Benzenesulfonates  

25265-71-8 Propanol, oxybis- Alcohols Yes Yes 

25265-77-4 Propanoic acid, 2-methyl-, 

monoester with 2,2,4-

trimethyl-1,3-pentanediol 

Esters Yes 

25339-17-7 Isodecanol Alcohols Yes Yes 

25496-72-4 9-Octadecenoic acid, (Z)-, 

monoester with 1,2,3-

propanetriol 

Esters Yes Yes 

26264-05-1 Benzenesulfonic acid, 

dodecyl-, compd. with 2-

propanamine (1:1) 

Benzenesulfonates  Yes 

26264-06-2 Benzenesulfonic acid, 

dodecyl-, calcium salt 

Benzenesulfonates  Yes Yes 

26264-58-4 Naphthalenesulfonic acid, 

methyl-, sodium salt 

Naphthalenesulfonates  

26447-40-5 Benzene, 1,1-methylenebis[isocyanatoIsocyanates Yes 

26471-62-5 Benzene, 1,3-

diisocyanatomethylIsocyanates Yes Yes 

26523-78-4 Phenol, nonyl-, phosphite 

(3:1) 

Phosphorus(III) Yes 

26761-40-0 1,2-Benzenedicarboxylic 

acid, diisodecyl ester 

Phthalates Yes 

27138-31-4 Propanol, oxybis-, 

dibenzoate 

Glycol ethers Yes 

27176-87-0 Benzenesulfonic acid, 

dodecylBenzenesulfonates 

 Yes Yes 

27178-16-1 Hexanedioic acid, diisodecyl 

ester 

Esters Yes Yes 

27193-86-8 Phenol, dodecyl- Phenols Yes 

28519-02-0 Benzenesulfonic acid, 

dodecyl(sulfophenoxy)-, 

disodium salt 

Benzenesulfonates  Yes 

28553-12-0 1,2-Benzenedicarboxylic 

acid, diisononyl ester 

Phthalates Yes EC 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

44

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

29385-43-1 1H-Benzotriazole, 4(or 5)-

methylBenzotriazoles Yes 

34590-94-8 Propanol, 1(or 2)-(2-

methoxymethylethoxy)- 

Glycol ethers Yes Yes 

36653-82-4 1-Hexadecanol Alcohols Yes Yes 

ORGANOMETALLICS 

78-00-2 Plumbane, tetraethyl- Lead Yes Yes 

147-14-8 Copper, [29H,31Hphthalocyaninato(2-)-

N29,N30,N31,N32]-, (SP-4-

1)- 

Copper-phthalocyanines  Yes 

4259-15-8 Zinc, bis[O,O-bis(2-

ethylhexyl) 

phosphorodithioato-S,S']-

,(T-4)- 

Zinc Yes 

ORGANIC-METAL SALTS 

557-05-1 Octadecanoic acid, zinc salt Zinc Yes Yes 

1103-38-4 1-Naphthalenesulfonic acid, 

2-[(2-hydroxy-1-

naphthalenyl)azo]-, barium 

salt (2:1) 

Barium-azo-βnaphthols  Yes Yes 

4485-12-5 Octadecanoic acid, lithium 

salt 

Lithium 

5160-02-1 Benzenesulfonic acid, 5-

chloro-2-[(2-hydroxy-1-

naphthalenyl)azo]-4-methyl-

, barium salt (2:1) 

Barium-azo-βnaphthols  Yes 

7620-77-1 Octadecanoic acid, 12-

hydroxy-, monolithium salt 

Lithium Yes 

POLYMERS 

9002-86-2 Ethene, chloro-, 

homopolymer 

Polyolefins 

9002-88-4 Ethene, homopolymer Polyolefins 

9002-89-5 Ethenol, homopolymer Vinyl polymers 

9002-92-0 Poly(oxy-1,2-ethanediyl), αdodecyl-ω-hydroxyPolyethers 

9002-93-1 Poly(oxy-1,2-ethanediyl), α-

[4-(1,1,3,3-tetramethylbutyl)phenyl]-ω-hydroxyPolyethers 

9003-01-4 2-Propenoic acid, 

homopolymer 

Polyacrylates 

9003-04-7 2-Propenoic acid, 

homopolymer, sodium salt 

Polyacrylates 

9003-05-8 2-Propenamide, 

homopolymer 

Polyamides 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

45

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

9003-07-0 1-Propene, homopolymer Polyolefins 

9003-08-1 1,3,5-Triazine-2,4,6-

triamine, polymer with 

formaldehyde 

Polyamines 

9003-11-6 Oxirane, methyl-, polymer 

with oxirane 

Polyethers 

9003-17-2 1,3-Butadiene, 

homopolymer 

Polyolefins 

9003-18-3 2-Propenenitrile, polymer 

with 1,3-butadiene 

Acrylonitrile–

butadiene 

copolymers 

 

9003-20-7 Acetic acid, ethenyl ester, 

homopolymer 

Vinyl polymers 

9003-22-9 Acetic acid, ethenyl ester, 

polymer with chloroethene 

Vinyl polymers 

9003-27-4 1-Propene, 2-methyl-, 

homopolymer 

Polyolefins 

9003-28-5 1-Butene, homopolymer Polyolefins 

9003-29-6 Butene, homopolymer Polyolefins 

9003-31-0 1,3-Butadiene, 2-methyl-, 

homopolymer 

Polyolefins 

9003-35-4 Phenol, polymer with 

formaldehyde 

Phenol–

formaldehyde 

copolymers 

 

9003-39-8 2-Pyrrolidinone, 1-ethenyl-, 

homopolymer 

Vinyl polymers 

9003-49-0 2-Propenoic acid, butyl 

ester, homopolymer 

Polyacrylates 

9003-53-6 Benzene, ethenyl-, 

homopolymer 

Polystyrenes 

9003-55-8 Benzene, ethenyl-, polymer 

with 1,3-butadiene 

Polystyrenes 

9003-56-9 2-Propenenitrile, polymer 

with 1,3-butadiene and 

ethenylbenzene 

Acrylonitrile–

butadiene–styrene 

copolymers 

 

9004-82-4 Poly(oxy-1,2-ethanediyl), αsulfo-ω-(dodecyloxy)-, 

sodium salt 

Polyethers Yes 

9005-09-8 2-Butenedioic acid (Z)-, 

polymer with chloroethene 

and ethenyl acetate 

Polycarboxylates 

9006-26-2 2,5-Furandione, polymer 

with ethane 

Polycarboxylates 

9008-63-3 Naphthalenesulfonic acid, 

sodium salt, polymer with 

formaldehyde 

Polysulfonates 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

46

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

9010-77-9 2-Propenoic acid, polymer 

with ethene 

Polyacrylates 

9010-79-1 1-Propene, polymer with 

ethane 

Polyolefins 

9010-85-9 1,3-Butadiene, 2-methyl-, 

polymer with 2-methyl-1-

propene 

Polyolefins 

9010-86-0 2-Propenoic acid, ethyl ester, 

polymer with ethane 

Polyacrylates 

9010-88-2 2-Propenoic acid, 2-methyl-, 

methyl ester, polymer with 

ethyl 2-propenoate 

Polymethacrylates 

9010-98-4 1,3-Butadiene, 2-chloro-, 

homopolymer 

Polyolefins 

9011-05-6 Urea, polymer with 

formaldehyde 

Polyurethanes 

9011-14-7 2-Propenoic acid, 2-methyl-, 

methyl ester, homopolymer 

Polymethacrylates 

9011-15-8 2-Propenoic acid, 2-methyl-, 

2-methylpropyl ester, 

homopolymer 

Polymethacrylates 

9011-17-0 1-Propene, 1,1,2,3,3,3-

hexafluoro-, polymer with 

1,1-difluoroethene 

Polyolefins 

9016-45-9 Poly(oxy-1,2-ethanediyl), α-

(nonylphenyl)-ω-hydroxyPolyethers Yes Yes 

9017-27-0 Benzene, ethenylmethyl-, 

polymer with (1-

methylethenyl)benzene 

Polystyrenes 

9036-19-5 Poly(oxy-1,2-ethanediyl), α-

[(1,1,3,3-tetramethylbutyl)phenyl]-ω-hydroxyPolyethers 

9038-95-3 Oxirane, methyl-, polymer 

with oxirane, monobutyl 

ether 

Polyethers 

9049-71-2 Poly[oxy(methyl-1,2-

ethanediyl)], α-hydro-ωhydroxy-, ether with β-Dfructofuranosyl α-Dglucopyranoside 

Polyethers 

9051-57-4 Poly(oxy-1,2-ethanediyl), αsulfo-ω-(nonylphenoxy)-, 

ammonium salt 

Polyethers Yes 

9082-00-2 Oxirane, methyl-, polymer 

with oxirane, ether with 

1,2,3-propanetriol (3:1) 

Polyethers 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

47

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

9084-06-4 Naphthalenesulfonic acid, 

polymer with formaldehyde, 

sodium salt 

Polysulfonates Yes 

24937-78-8 Acetic acid, ethenyl ester, 

polymer with ethane 

Vinyl polymers 

24938-91-8 Poly(oxy-1,2-ethanediyl), αtridecyl-ω-hydroxyPolyethers 

25014-31-7 Benzene, (1-methylethenyl)-

, homopolymer 

Polystyrenes 

25035-68-1 2-Propenoic acid, 2-methyl-, 

polymer with 

ethenylbenzene and ethyl 2-

propenoate 

Polymethacrylates 

25035-69-2 2-Propenoic acid, 2-methyl-, 

polymer with butyl 2-

propenoate and methyl 2-

methyl-2-propenoate 

Polymethacrylates 

25035-90-9 2-Butenedioic acid (Z)-, 

dibutyl ester, polymer with 

ethenylacetate 

Polycarboxylates 

25036-25-3 Phenol, 4,4'-(1-methylethylidene)bis-, polymer with 

2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]-

bis[oxirane] 

Polyethers 

25037-66-5 1,3-Isobenzofurandione, 

polymer with 2,5-furandione 

and 1,2-propanediol 

Polyesters 

25038-36-2 Bicyclo[2.2.1]hept-2-ene, 5-

ethylidene-, polymer with 

ethene and 1-propene 

Polyolefins 

25038-37-3 1,4-Hexadiene, polymer with 

ethene and 1-propene 

Polyolefins 

25038-54-4 Poly[imino(1-oxo-1,6-

hexanediyl)] 

Polyamines 

25038-59-9 Poly(oxy-1,2-

ethanediyloxycarbonyl-1,4-

phenylenecarbonyl) 

Polyethers 

25067-01-0 2-Propenoic acid, butyl 

ester, polymer with ethenyl 

acetate 

Polyacrylates 

25068-38-6 Phenol, 4,4'-(1-

methylethylidene)bis-, 

polymer with 

(chloromethyl)oxirane 

Polyethers 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

48

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

25085-02-3 2-Propenoic acid, sodium 

salt, polymer with 2-

propenamide 

Polyacrylates 

25085-99-8 Oxirane, 2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bis-, 

homopolymer 

Polyethers 

25087-34-7 1-Butene, polymer with 

ethane 

Polyolefins 

25133-97-5 2-Propenoic acid, 2-methyl-, 

polymer with ethyl 2-

propenoate and methyl 2-

methyl-2-propenoate 

Polymethacrylates 

25213-24-5 Acetic acid, ethenyl ester, 

polymer with ethanol 

Vinyl polymers 

25322-68-3 Poly(oxy-1,2-ethanediyl), αhydro-ω-hydroxyPolyethers Yes 

25322-69-4 Poly[oxy(methyl-1,2-

ethanediyl)], α-hydro-ωhydroxyPolyethers Yes 

25608-33-7 2-Propenoic acid, 2-methyl-, 

butyl ester, polymer with 

methyl 2-methyl-2-

propenoate 

Polymethacrylates 

25791-96-2 Poly[oxy(methyl-1,2-

ethanediyl)], α,α',α"-1,2,3-

propanetriyltris[ω-hydroxyPolyethers 

25852-37-3 2-Propenoic acid, 2-methyl-, 

methyl ester, polymer with 

butyl 2-propenoate 

Polymethacrylates 

25950-34-9 1,3-Benzenedicarboxylic 

acid, polymer with 2,2-

dimethyl-1,3-propanediol, 2-

ethyl-2-(hydroxymethyl)-

1,3-propanediol and 

hexanedioic acid 

Polyesters 

25987-30-8 2-Propenoic acid, polymer 

with 2-propenamide, sodium 

salt 

Acrylate–

acrylamide 

copolymers 

 

25987-66-0 2-Propenoic acid, 2-methyl-, 

polymer with butyl 2-

propenoate, ethenylbenzene 

and methyl 2-methyl-2-

propenoate 

Polymethacrylates 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

49

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

26006-22-4 Ethanaminium, N,N,Ntrimethyl-2-[(2-methyl-1-

oxo-2-propenyl)oxy]-, 

methyl sulfate, polymer with 

2-propenamide 

Polyamines 

26027-38-3 Poly(oxy-1,2-ethanediyl), α-

(4-nonylphenyl)-ω-hydroxyPolyethers Yes 

26062-79-3 2-Propen-1-aminium, N,Ndimethyl-N-2-propenyl-, 

chloride, homopolymer 

Polyamines 

26300-51-6 2-Propenoic acid, 2-methyl-, 

methyl ester, polymer with 

butyl 2-propenoate and 2-

propenoic acid 

Polymethacrylates 

26301-26-8 1,3-Benzenedicarboxylic 

acid, polymer with 2,5-

furandione and 1,2-

propanediol 

Polyesters 

26376-86-3 2-Propenoic acid, ethyl ester, 

polymer with 2-ethylhexyl 

2-propenoate 

Polyacrylates 

26780-96-1 Quinoline, 1,2-dihydro2,2,4-trimethyl-, 

homopolymer 

Polyamines 

28064-14-4 Phenol, polymer with 

formaldehyde, glycidyl ether 

Phenol–

formaldehyde 

copolymers 

 

30525-89-4 Paraformaldehyde Organic 

32131-17-2 Poly[imino(1,6-dioxo-1,6-

hexanediyl)imino-1,6-

hexanediyl] 

Polyamines Yes 

35429-19-7 Ethanaminium, N,N,Ntrimethyl-2-[(2-methyl-1-

oxo-2-propenyl)oxy]-, 

chloride, polymer with 2-

propenamide 

Polyamines 

36290-04-7 2-Naphthalenesulfonic acid, 

polymer with formaldehyde, 

sodium salt 

Polysulfonates Yes 

36484-54-5 Phenol, 4,4'-(1-

methylethylidene)bis-, 

polymer with 

(chloromethyl)oxirane and 

methyloxirane 

Polyethers 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

50

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

37199-81-8 2,5-Furandione, polymer 

with 2,4,4-trimethylpentene, 

sodium salt 

Polycarboxylates 

37625-93-7 2-Propenoic acid, polymer 

with (chloromethyl)oxirane 

and 4,4'-(1-methylethylidene)bis[phenol] 

Polyacrylates 

39382-25-7 2-Butenedioic acid, (E)-, 

polymer with α,α'-[(1-

methylethylidene)di-4,1-

phenylene]bis[hydroxypoly[oxy(methyl-1,2-

ethanediyl)]] 

Polycarboxylates 

42751-79-1 1,2-Ethanediamine, polymer 

with (chloromethyl)oxirane 

and N-methylmethanamine 

Polyamines 

52624-57-4 Oxirane, methyl-, polymer 

with oxirane, ether with 2-

ethyl-2-(hydroxymethyl)-

1,3-propanediol (3:1) 

Polyethers 

54579-44-1 Formaldehyde, polymer with 

4-(1,1-dimethylethyl)phenol 

and 4,4'-(1-methylethylidene)bis[phenol] 

Phenol–

formaldehyde 

copolymers 

 

65997-11-7 Rosin, fumarated, polymer 

with pentaerythritol 

Polyesters 

66070-60-8 Soybean oil, polymer with 

pentaerythritol and phthalic 

anhydride 

Polyesters 

66070-62-0 Fatty acids, tall oil, polymer 

with glycerol, pentaerythritol 

and phthalic anhydride 

Polyesters 

66070-65-3 Linseed oil, polymer with 

glycerol, pentaerythritol, 

phthalic anhydride and 

soybean oil 

Polyesters 

66070-71-1 Fatty acids, tall oil, polymer 

with glycerol and phthalic 

anhydride 

Polyesters 

67700-76-9 Soybean oil, polymer with 

ethylene glycol, 

pentaerythritol and phthalic 

anhydride 

Polyesters 

67700-92-9 Fatty acids, tall oil, polymer 

with pentaerythritol and 

phthalic anhydride 

Polyesters 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

51

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

67761-98-2 Fatty acids, tall oil, polymer 

with ethylene glycol, 

pentaerythritol and phthalic 

anhydride 

Polyesters 

67762-15-6 Soybean oil, polymer with 

maleic anhydride, pentaerythritol and phthalic 

anhydride 

Polyesters 

68002-19-7 Urea, polymer with 

formaldehyde, butylated 

Polyurethanes 

68002-20-0 1,3,5-Triazine-2,4,6-

triamine, polymer with 

formaldehyde, methylated 

Polyamines 

68002-25-5 1,3,5-Triazine-2,4,6-

triamine, polymer with 

formaldehyde, butylated 

Polyamines 

68037-01-4 1-Decene, homopolymer, 

hydrogenated 

Polyolefins 

68038-41-5 Rosin, maleated, polymer 

with glycerol 

Polyesters 

68240-01-7 4,7-Methano-1H-indene, 

3a,4,7,7a-tetrahydro-, 

polymer with 

ethenylbenzene, 

ethenylmethylbenzene, 1Hindene and (1-methylethenyl)benzene 

Polystyrenes 

68333-69-7 Rosin, maleated, polymer 

with pentaerythritol 

Polyesters 

68441-17-8 Ethene, homopolymer, 

oxidized 

Polyolefins 

68554-65-4 Siloxanes and silicones, 

diMe, polymer with Me 

silsesquioxanes and 

polyethylene-polypropylene 

glycol mono-Bu ether 

Polysiloxanes 

UVCBS 

1302-78-9 Bentonite Unsorted 

1312-76-1 Silicic acid, potassium salt Silicones & 

siloxanes 

 Yes 

1327-43-1 Silicic acid, aluminum 

magnesium salt 

Silicones & 

siloxanes 

 

1332-58-7 Kaolin Inorganics 

1333-86-4 Carbon black Inorganics Yes Yes 

1335-30-4 Silicic acid, aluminum salt Silicones & 

siloxanes 

 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

52

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

1338-24-5 Naphthenic acids Petroleums Yes 

1343-88-0 Silicic acid, magnesium salt Silicones & 

siloxanes 

 

1344-00-9 Silicic acid, aluminum 

sodium salt 

Silicones & 

siloxanes 

 Yes 

1344-09-8 Silicic acid, sodium salt Silicones & 

siloxanes 

 Yes 

1344-37-2 C.I. Pigment Yellow 34 Dyes & pigments Yes 

1344-95-2 Silicic acid, calcium salt Silicones & 

siloxanes 

 Yes 

8001-21-6 Sunflower oil Biologicals Yes 

8001-22-7 Soybean oil Biologicals Yes 

8001-26-1 Linseed oil Biologicals Yes 

8001-29-4 Cottonseed oil Biologicals Yes 

8001-30-7 Corn oil Biologicals Yes 

8001-31-8 Coconut oil Biologicals Yes Yes 

8001-78-3 Castor oil, hydrogenated Biologicals Yes Yes 

8002-03-7 Peanut oil Biologicals Yes 

8002-05-9 Petroleum Petroleums Yes 

8002-09-3 Oils, pine Biologicals Yes 

8002-26-4 Tall oil Biologicals Yes Yes 

8002-43-5 Lecithins Biologicals Yes 

8002-53-7 Montan wax Biologicals 

8002-74-2 Paraffin waxes and 

hydrocarbon waxes 

Petroleums Yes 

8006-64-2 Turpentine, oil Biologicals Yes Yes 

8007-01-0 Oils, rose Biologicals 

8007-02-1 Oils, lemongrass Biologicals 

8007-43-0 Sorbitan, (Z)-9-

octadecenoate (2:3) 

Biologicals Yes 

8007-45-2 Tar, coal Petroleums Yes Yes 

8008-20-6 Kerosine (petroleum) Petroleums Yes 

8008-52-4 Oils, coriander Biologicals 

8008-57-9 Oils, orange, sweet Biologicals Yes 

8009-03-8 Petrolatum Petroleums Yes 

8012-95-1 Paraffin oils Petroleums 

8013-07-8 Soybean oil, epoxidized Biologicals Yes Yes 

8016-28-2 Oils, lard Biologicals Yes 

8016-88-4 Oils, tarragon Biologicals 

8022-96-6 Oils, jasmine Biologicals 

8023-75-4 Oils, jonquil Biologicals 

8023-79-8 Oils, glyceridic, palm kernel Biologicals Yes Yes 

8024-05-3 Oils, tuberose Biologicals 

8024-06-4 Oils, vanilla Biologicals 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

53

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

8024-08-6 Oils, violet Biologicals 

8024-43-9 Perfumes and essences, 

jasmin 

Biologicals 

8029-43-4 Syrups, hydrolysed starch Biologicals Yes 

8030-12-4 Tallow, hydrogenated Biologicals Yes Yes 

8030-30-6 Naphtha Petroleums Yes 

8032-32-4 Ligroine Petroleums Yes Yes 

8042-47-5 White mineral oil 

(petroleum) 

Petroleums Yes 

8050-09-7 Rosin Biologicals Yes Yes 

8050-26-8 Resin acids and rosin acids, 

esters with pentaerythritol 

Biologicals Yes Yes 

8050-31-5 Resin acids and rosin acids, 

esters with glycerol 

Biologicals Yes Yes 

8052-10-6 Tall oil rosin Biologicals Yes Yes 

8052-41-3 Stoddard solvent Petroleums Yes Yes 

8052-42-4 Asphalt Petroleums Yes 

8052-48-0 Fatty acids, tallow, sodium 

salts 

Biologicals Yes Yes 

8061-51-6 Lignosulfonic acid, sodium 

salt 

Biologicals 

8061-52-7 Lignosulfonic acid, calcium 

salt 

Biologicals Yes 

8061-53-8 Lignosulfonic acid, 

ammonium salt 

Biologicals 

8062-15-5 Lignosulfonic acid Biologicals 

9000-30-0 Guar gum Biologicals 

9000-70-8 Gelatins Biologicals 

9000-71-9 Caseins Biologicals 

9004-32-4 Cellulose, carboxymethyl 

ether, sodium salt 

Biologicals 

9004-34-6 Cellulose Biologicals 

9004-35-7 Cellulose, acetate Biologicals 

9004-36-8 Cellulose, acetate butanoate Biologicals 

9004-39-1 Cellulose, acetate 

propanoate 

Biologicals 

9004-53-9 Dextrin Biologicals 

9004-57-3 Cellulose, ethyl ether Biologicals 

9004-58-4 Cellulose, ethyl 2-

hydroxyethyl ether 

Biologicals 

9004-62-0 Cellulose, 2-hydroxyethyl 

ether 

Biologicals 

9004-64-2 Cellulose, 2-hydroxypropyl 

ether 

Biologicals 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

54

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

9004-65-3 Cellulose, 2-hydroxypropyl 

methyl ether 

Biologicals 

9004-67-5 Cellulose, methyl ether Biologicals 

9004-70-0 Cellulose, nitrate Biologicals 

9005-25-8 Starch Biologicals 

9005-64-5 Sorbitan, monododecanoate, 

poly(oxy-1,2-ethanediyl) 

derivatives 

Biologicals 

9005-65-6 Sorbitan, mono-9-

octadecenoate, poly(oxy-1,2-

ethanediyl) derivatives, (Z)- 

Biologicals 

9005-67-8 Sorbitan, 

monooctadecanoate, 

poly(oxy-1,2-ethanediyl) 

derivatives 

Biologicals Yes 

9007-13-0 Resin acids and rosin acids, 

calcium salts 

Biologicals 

9007-34-5 Collagens Biologicals 

9016-87-9 Isocyanic acid, 

polymethylenepolyphenylene ester 

Unsorted 

9037-22-3 Amylopectin Biologicals 

9050-36-6 Maltodextrin Biologicals Yes 

11138-66-2 Xanthan gum Biologicals 

12001-26-2 Mica-group minerals Unsorted 

12001-85-3 Naphthenic acids, zinc salts Acids Yes 

12238-31-2 C.I. Pigment Red 52:2 Dyes & pigments 

12656-85-8 C.I. Pigment Red 104 Dyes & pigments Yes 

12713-03-0 Umber Unsorted 

12736-96-8 Silicic acid, aluminum 

potassium sodium salt 

Silicones & 

siloxanes 

 

37300-23-5 C.I. Pigment Yellow 36 Dyes & pigments 

39421-75-5 Guar gum, 2-hydroxypropyl 

ether 

Biologicals 

51274-00-1 C.I. Pigment Yellow 42 Dyes & pigments Yes 

53124-00-8 Starch, hydrogen phosphate, 

2-hydroxypropyl ether 

Biologicals 

57455-37-5 C.I. Pigment Blue 29 Dyes & pigments 

61788-46-3 Amines, coco alkyl Amines, amides; 

tallow derivatives 

 Yes Yes 

61788-47-4 Fatty acids, coco Biologicals Yes Yes 

61788-76-9 Alkanes, chloro Halogenated, 

aliphatic 

 Yes Yes 

61788-89-4 Fatty acids, C18-

unsaturated, dimers 

Biologicals Yes 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

55

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

61789-31-9 Fatty acids, coco, sodium 

salts 

Biologicals Yes Yes 

61789-36-4 Naphthenic acids, calcium 

salts 

Acids 

61789-80-8 Quaternary ammonium 

compounds, 

bis(hydrogenated tallow 

alkyl)dimethyl, chlorides 

Quaternary 

ammonium & 

tallow derivatives 

 Yes 

61789-86-4 Sulfonic acids, petroleum, 

calcium salts 

Unsorted Yes Yes 

61789-97-7 Tallow Biologicals Yes Yes 

61790-12-3 Fatty acids, tall oil Biologicals Yes Yes 

61790-14-5 Naphthenic acids, lead salts Acids 

61790-44-1 Fatty acids, tall oil, 

potassium salts 

Biologicals Yes 

61790-48-5 Sulfonic acids, petroleum, 

barium salts 

Unsorted Yes 

61790-51-0 Resin acids and rosin acids, 

sodium salts 

Biologicals Yes Yes 

61790-59-8 Amines, hydrogenated 

tallow alkyl, acetates 

Amines, amides; 

tallow derivatives 

 

61790-88-3 Fatty acids, tall oil, triesters 

with sorbitan, ethoxylated 

Biologicals 

61791-00-2 Fatty acids, tall oil, 

ethoxylated 

Biologicals 

61791-01-3 Fatty acids, tall oil, diesters 

with polyethylene glycol 

Biologicals Yes 

61791-12-6 Castor oil, ethoxylated Biologicals 

61791-26-2 Amines, tallow alkyl, 

ethoxylated 

Amines, amides; 

tallow derivatives 

 

61791-31-9 Ethanol, 2,2'-iminobis-, Ncoco alkyl derivatives Alcohols & 

ethoxylated 

products 

 Yes Yes 

61791-55-7 Amines, N-tallow 

alkyltrimethylenediAmines, amides; tallow derivatives 

 Yes Yes 

63148-62-9 Siloxanes and silicones, 

diMe 

Silicones & 

siloxanes 

 

63231-60-7 Paraffin waxes and 

hydrocarbon waxes, 

microcryst. 

Petroleums Yes 

63231-67-4 Silica gel Silicones & 

siloxanes 

 

63449-39-8 Paraffin waxes and 

hydrocarbon waxes, chloro 

Petroleums Yes Yes 

64147-40-6 Castor oil, dehydrated Biologicals Yes 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

56

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

64741-41-9 Naphtha (petroleum), heavy 

straight-run 

Petroleums Yes 

64741-42-0 Naphtha (petroleum), fullrange straight-run Petroleums Yes 

64741-43-1 Gas oils (petroleum), 

straight-run 

Petroleums Yes 

64741-44-2 Distillates (petroleum), 

straight-run middle 

Petroleums Yes 

64741-45-3 Residues (petroleum), atm. 

tower 

Petroleums Yes 

64741-46-4 Naphtha (petroleum), light 

straight-run 

Petroleums Yes 

64741-47-5 Natural gas condensates 

(petroleum) 

Petroleums Yes 

64741-53-3 Distillates (petroleum), 

heavy naphthenic 

Petroleums Yes 

64741-54-4 Naphtha (petroleum), heavy 

catalytic cracked 

Petroleums Yes 

64741-55-5 Naphtha (petroleum), light 

catalytic cracked 

Petroleums Yes 

64741-56-6 Residues (petroleum), 

vacuum 

Petroleums Yes 

64741-57-7 Gas oils (petroleum), heavy 

vacuum 

Petroleums Yes 

64741-59-9 Distillates (petroleum), light 

catalytic cracked 

Petroleums Yes 

64741-62-4 Clarified oils (petroleum), 

catalytic cracked 

Petroleums Yes 

64741-63-5 Naphtha (petroleum), light 

catalytic reformed 

Petroleums Yes Yes 

64741-65-7 Naphtha (petroleum), heavy 

alkylate 

Petroleums Yes Yes 

64741-67-9 Residues (petroleum), 

catalytic reformer 

fractionator 

Petroleums Yes 

64741-68-0 Naphtha (petroleum), heavy 

catalytic reformed 

Petroleums Yes 

64741-69-1 Naphtha (petroleum), light 

hydrocracked 

Petroleums Yes 

64741-72-6 Naphtha (petroleum), 

polymn. 

Petroleums 

64741-79-3 Coke (petroleum) Petroleums Yes 

64741-81-7 Distillates (petroleum), 

heavy thermal cracked 

Petroleums Yes 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

57

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

64741-82-8 Distillates (petroleum), light 

thermal cracked 

Petroleums Yes 

64741-86-2 Distillates (petroleum), 

sweetened middle 

Petroleums Yes 

64741-88-4 Distillates (petroleum), 

solvent-refined heavy 

paraffinic 

Petroleums Yes 

64741-89-5 Distillates (petroleum), 

solvent-refined light 

paraffinic 

Petroleums Yes 

64741-95-3 Residual oils (petroleum), 

solvent deasphalted 

Petroleums Yes 

64741-96-4 Distillates (petroleum), 

solvent-refined heavy 

naphthenic 

Petroleums Yes 

64741-97-5 Distillates (petroleum), 

solvent-refined light 

naphthenic 

Petroleums Yes 

64742-01-4 Residual oils (petroleum), 

solvent-refined 

Petroleums Yes 

64742-04-7 Extracts (petroleum), heavy 

paraffinic distillate solvent 

Petroleums Yes 

64742-06-9 Extracts (petroleum), middle 

distillate solvent 

Petroleums Yes Yes 

64742-16-1 Petroleum resins Petroleums Yes 

64742-23-0 Naphtha (petroleum), 

chemically neutralized light 

Petroleums Yes 

64742-30-9 Distillates (petroleum), 

chemically neutralized 

middle 

Petroleums Yes 

64742-34-3 Distillates (petroleum), 

chemically neutralized heavy 

naphthenic 

Petroleums Yes 

64742-40-1 Neutralizing agents 

(petroleum), spent sodium 

hydroxide 

Petroleums Yes 

64742-42-3 Hydrocarbon waxes 

(petroleum), clay-treated 

microcryst. 

Petroleums Yes 

64742-43-4 Paraffin waxes (petroleum), 

clay-treated 

Petroleums Yes 

64742-46-7 Distillates (petroleum), 

hydrotreated middle 

Petroleums Yes Yes 

64742-47-8 Distillates (petroleum), 

hydrotreated light 

Petroleums Yes Yes 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

58

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

64742-48-9 Naphtha (petroleum), 

hydrotreated heavy 

Petroleums Yes Yes 

64742-49-0 Naphtha (petroleum), 

hydrotreated light 

Petroleums Yes Yes 

64742-51-4 Paraffin waxes (petroleum), 

hydrotreated 

Petroleums Yes 

64742-52-5 Distillates (petroleum), 

hydrotreated heavy 

naphthenic 

Petroleums Yes 

64742-53-6 Distillates (petroleum), 

hydrotreated light 

naphthenic 

Petroleums Yes 

64742-54-7 Distillates (petroleum), 

hydrotreated heavy 

paraffinic 

Petroleums Yes 

64742-55-8 Distillates (petroleum), 

hydrotreated light paraffinic 

Petroleums Yes 

64742-56-9 Distillates (petroleum), 

solvent-dewaxed light 

paraffinic 

Petroleums Yes 

64742-57-0 Residual oils (petroleum), 

hydrotreated 

Petroleums Yes 

64742-61-6 Slack wax (petroleum) Petroleums Yes 

64742-62-7 Residual oils (petroleum), 

solvent-dewaxed 

Petroleums Yes 

64742-63-8 Distillates (petroleum), 

solvent-dewaxed heavy 

naphthenic 

Petroleums Yes 

64742-65-0 Distillates (petroleum), 

solvent-dewaxed heavy 

paraffinic 

Petroleums Yes 

64742-73-0 Naphtha (petroleum), 

hydrodesulfurized light 

Petroleums Yes 

64742-80-9 Distillates (petroleum), 

hydrodesulfurized middle 

Petroleums Yes Yes 

64742-81-0 Kerosine (petroleum), 

hydrodesulfurized 

Petroleums Yes Yes 

64742-88-7 Solvent naphtha (petroleum), 

medium aliph. 

Petroleums Yes Yes 

64742-89-8 Solvent naphtha (petroleum), 

light aliph. 

Petroleums Yes Yes 

64742-93-4 Asphalt, oxidized Petroleums Yes 

64742-94-5 Solvent naphtha (petroleum), 

heavy aromatic 

Petroleums Yes Yes 

64742-95-6 Solvent naphtha (petroleum), 

light aromatic 

Petroleums Yes Yes 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

59

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

64742-96-7 Solvent naphtha (petroleum), 

heavy aliphatic 

Petroleums Yes 

64743-05-1 Coke (petroleum), calcined Petroleums Yes 

65996-61-4 Pulp, cellulose Biologicals 

65996-62-5 Starch, oxidized Biologicals 

65996-63-6 Starch, acid-hydrolysed Biologicals Yes 

65996-93-2 Pitch, coal tar, hightemperature Petroleums Yes 

65997-04-8 Rosin, fumarated Biologicals Yes Yes 

65997-05-9 Rosin, polymd. Biologicals 

65997-06-0 Rosin, hydrogenated Biologicals Yes Yes 

65997-15-1 Cement, portland, chemicals Unsorted 

65997-16-2 Cement, alumina, chemicals Unsorted 

65997-17-3 Glass, oxide, chemicals Inorganics 

65997-18-4 Frits, chemicals Inorganics 

66071-92-9 Sulfite liquors and cooking 

liquors, spent 

Unsorted Yes 

66071-96-3 Glutens, corn Biologicals 

66402-68-4 Ceramic materials and 

wares, chemicals 

Unsorted 

66455-14-9 Alcohols, C12–13, 

ethoxylated 

Alcohols & 

ethoxylated 

products 

 

67701-03-5 Fatty acids, C16–18 Biologicals Yes Yes 

67762-19-0 Poly(oxy-1,2-ethanediyl), αsulfo-ω-hydroxy-, C10–16-

alkyl ethers, ammonium salts 

Polymers Yes 

67762-30-5 Alcohols, C14–18 Alcohols & 

ethoxylated 

products 

 Yes Yes 

67762-90-7 Siloxanes and silicones, 

diMe, reaction products with 

silica 

Silicones & 

siloxanes 

 

67774-74-7 Benzene, C10–13-alkyl 

derivatives 

Petroleums Yes 

68002-97-1 Alcohols, C10–16, 

ethoxylated 

Alcohols & 

ethoxylated 

products 

 

68037-64-9 Siloxanes and silicones, 

diMe, Me hydrogen, reaction 

products with polyethylenepolypropylene glycol 

monoacetate allylether 

Silicones & 

siloxanes 

 

68131-31-7 Sulfite liquors and cooking 

liquors, spent, alkali-treated 

Unsorted 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

60

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

68131-37-3 Syrups, corn, dehydrated Biologicals 

68131-39-5 Alcohols, C12–15, 

ethoxylated 

Alcohols & 

ethoxylated 

products 

 

68153-22-0 Paraffin waxes and 

hydrocarbon waxes, 

oxidized 

Petroleums Yes 

68187-11-1 C.I. Pigment Blue 36 Dyes & pigments 

68213-23-0 Alcohols, C12–18, 

ethoxylated 

Alcohols & 

ethoxylated 

products 

 

68333-88-0 Aromatic hydrocarbons, C9–

17 

Petroleums Yes 

68334-30-5 Fuels, diesel Petroleums Yes 

68391-11-7 Pyridine, alkyl derivatives Unsorted Yes Yes 

68410-23-1 Fatty acids, C18-

unsaturated, dimers, reaction 

products with polyethylenepolyamines 

Biologicals Yes 

68410-99-1 Alkenes, polymd., 

chlorinated 

Polymers 

68411-30-3 Benzenesulfonic acid, C10–

13-alkyl derivatives, sodium 

salts 

Linear alkyl 

benzene 

sulfonates 

 Yes 

68412-54-4 Poly(oxy-1,2-ethanediyl), α-

(nonylphenyl)-ω-hydroxy-, 

branched 

Polymers 

68439-45-2 Alcohols, C6–12, 

ethoxylated 

Alcohols & 

ethoxylated 

products 

 

68439-46-3 Alcohols, C9–11, 

ethoxylated 

Alcohols & 

ethoxylated 

products 

 

68439-50-9 Alcohols, C12–14, 

ethoxylated 

Alcohols & 

ethoxylated 

products 

 

68439-57-6 Sulfonic acids, C14–16-

alkane hydroxy and C14–16-

alkene, sodium salts 

Unsorted Yes Yes 

68476-03-9 Fatty acids, montan-wax Biologicals Yes 

68476-30-2 Fuel oil, no. 2 Petroleums Yes 

68476-34-6 Fuels, diesel, no. 2 Petroleums Yes 

68476-86-8 Petroleum gases, liquefied, 

sweetened 

Petroleums Yes 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

61

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

68477-31-6 Distillates (petroleum), 

catalytic reformer 

fractionator residue, lowboiling 

Petroleums Yes Yes 

68477-77-0 Gases (petroleum), catalytic 

reformed naphtha stripper 

overheads 

Petroleums Yes 

68513-02-0 Naphtha (petroleum), fullrange coker Petroleums Yes 

68553-00-4 Fuel oil, no. 6 Petroleums Yes 

68584-22-5 Benzenesulfonic acid, C10–

16-alkyl derivs. 

Linear alkyl 

benzene 

sulfonates 

 Yes Yes 

68585-34-2 Poly(oxy-1,2-ethanediyl), αsulfo-ω-hydroxy-, C10–16-

alkyl ethers, sodium salts 

Polymers Yes 

68603-15-6 Alcohols, C6–12 Alcohols & 

ethoxylated 

products 

 Yes Yes 

68603-42-9 Amides, coco, N,Nbis(hydroxyethyl) Amines, amides; 

tallow derivatives 

 Yes Yes 

68608-26-4 Sulfonic acids, petroleum, 

sodium salts 

Unsorted Yes Yes 

68648-87-3 Benzene, C10–16-alkyl 

derivatives 

Petroleums Yes 

68649-11-6 1-Decene, dimer, 

hydrogenated 

Hydrocarbons, 

aliphatic 

 Yes 

68649-12-7 1-Decene, tetramer, mixed 

with 1-decene trimer, 

hydrogenated 

Hydrocarbons, 

aliphatic 

 Yes 

68649-42-3 Phosphorodithioic acid, o,odi-C1–14-alkyl esters, zinc 

salts 

Acids Yes Yes 

68784-26-9 Phenol, dodecyl-, sulfurized, 

carbonates, calcium salts, 

overbased 

Phenolics Yes Yes 

68855-54-9 Kieselguhr, soda ash fluxcalcined Inorganics 

68909-18-2 Pyridinium, 1-

(phenylmethyl)-, Et Me 

derivatives, chlorides 

Unsorted Yes Yes 

68909-77-3 Ethanol, 2,2'-oxybis-, 

reaction products with 

ammonia, morpholine 

derivative residues 

Reaction products Yes 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

62

CAS 

registry 

number 

Chemical name Chemical group CEPA 

1999 

Schedule 

1 

PSL U.S. 

HPV 

ICCA 

list 

2003 

HC/EC 

pilot 

68915-97-9 Gas oils (petroleum), 

straight-run, high-boiling 

Petroleums Yes 

68919-37-9 Naphtha (petroleum), fullrange reformed Petroleums Yes 

68937-41-7 Phenol, isopropylated, 

phosphate (3:1) 

Phenolics Yes Yes 

68951-67-7 Alcohols, C14–15, 

ethoxylated 

Alcohols & 

ethoxylated 

products 

 

68953-58-2 Quaternary ammonium 

compounds, 

bis(hydrogenated tallow 

alkyl)dimethyl, salts with 

bentonite 

Quaternary 

ammonium & 

tallow derivatives 

 Yes Yes 

68955-35-1 Naphtha (petroleum), 

catalytic reformed 

Petroleums Yes 

68955-53-3 Amines, C12–14-tert-alkyl Amines, amides; 

tallow derivatives 

 Yes 

68990-53-4 Glycerides, C14–22 mono- Biologicals Yes 

69430-24-6 Cyclosiloxanes, diMe Silicones & 

siloxanes 

 

70131-50-9 Bentonite, acid-leached Unsorted Yes 

70131-67-8 Siloxanes and silicones, 

diMe, hydroxy-terminated 

Silicones & 

siloxanes 

 

70592-78-8 Distillates (petroleum), 

vacuum 

Petroleums Yes 

70693-06-0 Aromatic hydrocarbons, C9–

11 

Petroleums Yes Yes 

70914-12-4 Siloxanes and silicones, 

diMe, 3-hydroxypropyl Me, 

ethers with polyethylene 

glycol acetate 

Silicones & 

siloxanes 

 

93763-70-3 Perlite, expanded Unsorted 

112926-00-8 Silica gel, pptd., cryst.-free Silicones & 

siloxanes 

 

112945-52-5 Silica, amorphous, fumed, 

cryst.-free 

Silicones & 

siloxanes 

 

Note: EC = Environment Canada; HC = Health Canada. 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

63

Appendix B: Tables of Functional Use Codes, Industrial Sector Codes and Quantity Codes 

Table B1: Use codes for DSL report forms

Special Use Codes 

00 Research and development 

01 Site-limited substance

Functional Use Codes

02 Absorbent/adsorbent 

03 Abrasive 

04 Adhesive/binder/sealant/filler 

05 Analytical reagent 

06 Antifreeze/coolant/deicer 

07 Antioxidant/corrosion inhibitor/tarnish inhibitor/scavanger/antiscaling agent 

08 Catalyst/accelerator/initiator/activator 

09 Catalyst support/chromatography support 

10 Chemical intermediate - organic 

11 Chemical intermediate - inorganic, organometallic 

12 Coagulant/coalescent 

13 Colorant - pigment/stain/dye/ink 

14 Defoamer/emulsion breaker 

15 Drilling mud additive/oil recovery agent/oil well treating agent 

16 Fertilizer 

17 Finishing agent 

18 Flame retardant/fire extinguishing agent 

19 Flocculating/precipitating/clarifying agent 

20 Flotation agent 

21 Formulation component 

22 Fragrance/perfume/deodourizer/flavouring agent 

23 Fuel/fuel additive 

24 Functional fluid, i.e., hydraulic, dielectric, or their additives 

25 Humectant/dewatering aid/dehumidifier/dehydrating agent 

26 Ion exchange agent 

27 Lubricating agent/lubricant additive/mould release agent 

28 Monomer 

29 Oxidizing agent 

30 Paint/coating additive 

31 Pesticide/herbicide/biocide/disinfectant/repellant/attractant 

32 Photosensitive agent - fluorescent agent/brightener/UV absorber 

33 Plasticizer 

34 Polymer additive 

35 Polymer, component of an article 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

64

36 Polymer, component of a formulation 

37 Polymer, crosslinking agent 

38 Propellant/blowing agent 

39 Preservative 

40 Processing aid 

41 Reducing agent 

42 Refrigerant 

43 Sequestering agent 

44 Solvent/carrier 

45 Stripper/etcher/discharge printing agent/de-inker 

46 Surfactant – detergent/emulsifier/wetting agent/dispersant 

47 Tarnish remover/rust remover/descaling agent 

48 Viscosity adjuster 

49 Water repellant/drainage aid 

50 Water or waste treatment chemical 

51 Function other than that listed in codes 02 to 50 

Industrial Sector Codes 

52 Adhesive and sealant production 

53 Agriculture, field crops 

54 Agriculture, other 

55 Article manufacture 

56 Automotive, aircraft and watercraft 

57 Biotechnology 

58 Chlor-alkali 

59 Construction materials 

60 Cosmetics 

61 Electrical or electronic products 

62 Explosive materials 

63 Fertilizer 

64 Forestry/wood products/wood treatment 

65 Food, feed, and beverage 

66 Health and veterinary 

67 Industrial gas production 

68 Inorganic chemicals 

69 Magnetic tape manufacture 

70 Leather/tanning 

71 Metallurgical 

72 Mining, metal and non-metal 

73 Non-metallic mineral products, abrasive 

74 Non-metallic mineral products, ceramic and glass 

75 Non-metallic mineral products, other 

76 Organic chemicals, industrial 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

65

77 Organic chemicals, speciality 

78 Organometallic chemicals 

79 Packaging 

80 Paint and coating 

81 Pest control products/formulating and manufacture 

82 Petroleum and natural gas 

83 Pharmaceuticals 

84 Photographic/photocopier 

85 Pigment, dye and printing ink 

86 Plastics 

87 Plastic and synthetic resin 

88 Plating and surface finishing 

89 Printing and publishing 

90 Pulp and paper 

91 Refined petroleum and coal products 

92 Rubber products 

93 Soap and cleaning products 

94 Textile, primary manufacture 

95 Textile, product 

96 Transportation 

97 Water and waste treatment 

98 Used in an industry other than those specified in codes 51–97 

Table B2: Quantity codes (1986 data)

Quantity code Quantity range (kg)

A Under 100 

B 100 – 1 000 

C 1 000 – 10 000 

D 10 000 – 100 000 

E 100 000 – 1 000 000 

F 1 000 000 – 10 000 000 

G over 10 000 000 

N Nila

a Substance does not meet eligibility criteria in 1986, but did meet eligibility criteria in 1984 or 1985.
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

66

Appendix C: Development of the Use Code Indices and Ranking of Functional Use and 

Industrial Sector Codes for “Potential for Human Exposure” 

Workshops to Consider DSL Use Codes

Two workshops were held to consider the use of functional use and industrial sector 

codes as indicators of “potential for human exposure.” Participants in the first workshop, which 

was held on May 30, 2001, were government personnel involved in human health and 

environmental assessment. Participants in the second workshop, held on October 18, 2002, were 

industry representatives familiar with the manufacture and use of the substances on the DSL. 

Procedures in the second workshop were identical to those in the first, and the reports of both are 

available as supporting documentation to this proposal. 

The objective of the workshops was to investigate the premise that some qualitative 

indication of the potential human exposure to a specific DSL substance can be inferred by 

consideration of some or all of the specific use codes reported by companies that were importing, 

manufacturing or using that substance when the DSL was compiled. Relevant background 

information was provided, and the participants were asked to evaluate whether the DSL 

functional use and industrial sector codes could reasonably be expected to represent “greatest,” 

“intermediate” or “least” potential for human exposure, on the basis of “expert judgement” when 

evaluated against predefined criteria. The degrees of consensus concerning the potential for 

human exposure that might be inferred by each of the codes were determined by post-workshop 

analyses of worksheets completed by the participants, and an “exposure index” ranking for each 

substance on the DSL was established on this basis. 

 

Ranking of the Use Codes 

Based on preliminary inspection of the results from the two workshops, there were 

similarities between the combined ranking of the two expert groups. To investigate this 

similarity, paired ranking data were compared statistically using a chi-squared test. The results of 

this test indicated that for the 49 functional use codes ranked, 13 were ranked differently 

between the two workshops at the p = 0.05 level, and 0 were ranked differently at the p = 0.01 

level. Similarly, for the 46 industrial sector codes ranked, 8 were ranked differently at the p = 

0.05 level, with 1 being ranked differently at the p = 0.01 level. These differences can be 

ascribed to two factors: 

• different numbers of participants in the two workshops (20 attendees at the government 

workshop and 13 attendees at the industry workshop); and 

• different interpretations of the criteria for “potential for exposure”; the industry participants 

seemed to focus more on “consumer product” exposure, whereas the government participants 

interpreted the criteria more generally. 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

67

Overall, 21 of 95 codes evaluated were ranked differently at the p = 0.05 level, and only 

1 of 95 was ranked differently at the p = 0.01 level. Based on the similarity of the remainder of 

the rankings (74 of 95), the results from the two workshops were combined. 

Scaling factors were then assigned to each level of potential for exposure, namely 1 for 

“least,” 10 for “intermediate” and 100 for “greatest.” These factors were chosen to reflect the 

appropriate relative variation in exposure represented by the different categories. The results for 

each functional use and industrial sector code were then calculated and normalized to the number 

of workshop participants. Using this approach, the highest possible ranking would be 100 and 

the lowest 0. For example, if the survey results for a code were 10 “least’s”, 10 “intermediate’s” 

and 13 “greatest’s”, the score would be: 

(10 ×1) + (10 × 10) + (13 × 100) = 1410 

least intermediate greatest 

The 1410 score was then divided by 33 (the number of workshop participants) to arrive at 

a final ranking index of 42.7. The overall ranking indices calculated for each functional use or 

industrial sector code are listed below. 

For use (U), all 22 264 substances on the DSL were ranked in descending order on the 

basis of their sums of normalized indices of expert-ranked functional use and industrial sector 

codes for each substance. The sum of the use indices for each substance ranged from 13 227 to 0. 

Table C1: Ranking of functional use and industrial sector codes for “potential for human exposure”

Use 

code 

Description Ranking 

index 

Normalized use code 

index 

Functional use 

22 Fragrance/perfume/deodourizer/flavouring agent 3120 94.55 

46 Surfactant - detergent/emulsifier/wetting agent/dispersant 2850 86.36 

44 Solvent/carrier 2670 80.91 

23 Fuel/fuel additive 2580 78.18 

31 Pesticide/herbicide/biocide/disinfectant/repellant/ 

attractant 

2580 78.18 

39 Preservative 2571 77.91 

30 Paint/coating additive 2283 69.18 

13 Colourant - pigment/stain/dye/ink 2202 66.73 

16 Fertilizer 1842 55.82 

04 Adhesive/binder/sealant/filler 1806 54.73 

21 Formulation component 1734 52.55 

35 Polymer, component of an article 1716 52.00 

32 Photosensitive agent - fluorescent agent/brightener/UV 

absorber 

1599 48.45 

06 Antifreeze/coolant/deicer 1455 44.09 

50 Water or waste treatment chemical 1446 43.82 

18 Flame retardant/fire extinguishing agent 1410 42.73 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

68

Use 

code 

Description Ranking 

index 

Normalized use code 

index 

33 Plasticizer 1401 42.45 

27 Lubricating agent/lubricant additive/mould release agent 1347 40.82 

38 Propellant/blowing agent 1311 39.73 

47 Tarnish remover/rust remover/descaling agent 1068 32.36 

02 Absorbent/adsorbent 1023 31.00 

03 Abrasive 1023 31.00 

17 Finishing agent 933 28.27 

36 Polymer, component of a formulation 897 27.18 

45 Stripper/etcher/discharge printing agent/de-inker 834 25.27 

07 Antioxidant/corrosion inhibitor/tarnish inhibitor/ 

scavenger/antiscaling agent 

816 24.73 

49 Water repellant/drainage aid 708 21.45 

12 Coagulant/coalescent 645 19.55 

29 Oxidizing agent 627 19.00 

25 Humectant/dewatering aid/dehumidifier/dehydrating 

agent 

609 18.45 

43 Sequestering agent 609 18.45 

28 Monomer 591 17.91 

48 Viscosity adjuster 582 17.64 

14 Defoamer/emulsion breaker 564 17.09 

24 Functional fluid, i.e., hydraulic, dielectric, or their 

derivatives 

564 17.09 

34 Polymer additive 492 14.91 

37 Polymer, crosslinking agent 492 14.91 

19 Flocculating/precipitating/clarifying agent 420 12.73 

42 Refrigerant 393 11.91 

41 Reducing agent 321 9.73 

40 Processing aid 276 8.36 

20 Flotation agent 204 6.18 

05 Analytical reagent 159 4.82 

08 Catalyst/accelerator/initiator/activator 87 2.64 

26 Ion exchange agent 87 2.64 

11 Chemical intermediate - inorganic, organometallic 69 2.09 

10 Chemical intermediate - organic 60 1.82 

15 Drilling mud additive/oil recovery agent/oil well treating 

agent 

60 1.82 

09 Catalyst support/chromatography support 42 1.27 

Industrial sector

93 Soap and cleaning products 2641 85.19 

53 Agriculture, field crops 2551 82.29 

82 Petroleum and natural gas 2443 78.81 

60 Cosmetics 2272 73.29 

65 Food, feed, and beverage 2254 72.71 

81 Pest control products, formulating and manufacture 2182 70.39 

91 Refined petroleum and coal products 2101 67.77 

63 Fertilizer 2101 67.77 

64 Forestry/wood products/wood treatment 2074 66.90 

97 Water and waste treatment 2002 64.58 
Priority Setting for Existing Substances: Greatest Potential for Human Exposure 

69

Use 

code 

Description Ranking 

index 

Normalized use code 

index 

54 Agriculture, other 1957 63.13 

83 Pharmaceuticals 1903 61.39 

96 Transportation 1786 57.61 

80 Paint and coating 1714 55.29 

90 Pulp and paper 1615 52.10 

59 Construction materials 1525 49.19 

58 Chlor-alkali 1435 46.29 

66 Health and veterinary 1399 45.13 

95 Textile, product 1381 44.55 

89 Printing and publishing 1372 44.26 

70 Leather/tanning 1165 37.58 

67 Industrial gas production 1165 37.58 

68 Inorganic chemicals 1147 37.00 

72 Mining, metal and non-metal 1129 36.42 

57 Biotechnology 1093 35.26 

86 Plastics 1084 34.97 

92 Rubber products 967 31.19 

85 Pigment, dye and printing ink 967 31.19 

56 Automotive, aircraft and watercraft 931 30.03 

79 Packaging 931 30.03 

87 Plastic and synthetic resin 913 29.45 

78 Organometallic chemicals 814 26.26 

94 Textile, primary manufacture 796 25.68 

76 Organic chemicals, industrial 778 25.10 

61 Electrical or electronic products 679 21.90 

88 Plating and surface finishing 652 21.03 

71 Metallurgical 652 21.03 

74 Non-metallic mineral products, ceramic and glass 634 20.45 

84 Photographic/photocopier 598 19.29 

77 Organic chemicals, speciality 571 18.42 

75 Non-metallic mineral products, other 436 14.06 

73 Non-metallic mineral products, abrasive 436 14.06 

55 Article manufacture 409 13.19 

69 Magnetic tape manufacture 364 11.74 

52 Adhesive and sealant production 328 10.58 

62 Explosive materials 301 9.71