United States Chemical Safety September 2011

Environmental Protection and Pollution Prevention

Agency (7510P)

Alkyl Imidazolines

Summary Document:

Registration Review: Initial Docket

Docket Number: EPA-HQ-OPP-2011-0620

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TABLE OF CONTENTS

Alkyl Imidazolines Registration Review Team...................................................................4

I. Preliminary Work Plan .....................................................................................................5

II. Fact Sheet ......................................................................................................................12

III. Summary of Anticipated Data Requirements..............................................................15

IV. Appendix A..................................................................................................................16

________________________________________

Please Note

This Preliminary Work Plan and Fact Sheet summarize the Environmental Protection Agency's 

current position based on the following documents:

1. Summary of Product Chemistry, Environmental Fate, and Ecotoxicity Data for the 1-(2-

Hydroxyethyl)-2-alkyl-2-imidazoline (as in fatty acids of tall oil) Registration Review 

Decision Document. August 11, 2011

2. Alkyl Imidazoline: Human Health Risk Assessment Scoping Document in Support of 

Registration Review. August 9, 2011

Additional supporting documents for the Alkyl Imidazolines Case may be found in the 

registration review docket EPA-HQ-OPP-2011-0620 located on the internet at

www.regulations.gov.
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Alkyl Imidazolines Registration Review Team

Human Health & Environmental Effects

Timothy Dole

Srinivas Gowda

Risk Management

Eliza Blair

Lance Wormell

Office of General Counsel

Philip Ross
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I. Preliminary Work Plan -- Alkyl Imidazolines

Introduction:

The Food Quality Protection Act (FQPA) of 1996 mandated a registration review program. All 

pesticides distributed or sold in the United States generally must be registered by the U.S. 

Environmental Protection Agency (USEPA, EPA, or the Agency) based on scientific data 

showing that they will not cause unreasonable risks to human health or the environment when 

used as directed on product labeling. The registration review program is intended to make sure 

that, as the ability to assess risk evolves and as policies and practices change, all registered 

pesticides continue to meet the statutory standard of no unreasonable adverse effects to human 

health or the environment. Changes in science, public policy, and pesticide use practices will 

occur over time. Through the registration review program, the Agency periodically reevaluates 

pesticides to make sure that as change occurs, products in the marketplace can be used safely. 

Information on this program is provided at http://www.epa.gov/oppsrrd1/registration_review/.

The Agency is implementing the registration review program pursuant to Section 3(g) of the 

Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and will review each registered 

pesticide every 15 years to determine whether it continues to meet the FIFRA standard for 

registration. The Agency will consider benefits information and data as required by FIFRA. The 

public phase of registration review begins when the initial docket is opened for each case. The 

docket is the Agency’s opportunity to state what it knows about the pesticide and what additional 

risk analyses and data or information it believes are needed to make a registration review 

decision. After reviewing and responding to comments and data received in the docket during 

this initial comment period, the Agency will develop and commit to a final work plan and 

schedule for the Alkyl Imidazolines Case.

Alkyl imidazoline is a microbiocide/microbiostat registered for use in fuel and oil storage tank 

bottom water. Products containing alkyl imidazoline are registered for use to prevent the growth 

of slime-forming bacteria and fungi which might interfere with the use and quality of oils and 

fuels in storage tanks. There is one soluble concentrate liquid product, with 25% active 

ingredient. The product is loaded and applied through a closed delivery system that has a 

proportioning pump or siphon type feeder to meter the pesticide product directly from the 

product container into the fuel oil as it is pumped into storage tanks. The product is not registered 

for homeowner use or for use in or around residences.

There are two active ingredients in the Alkyl imidazolines Case 3010; however, one of these 

active ingredients, 2-heptadecentyl-2-imidazoline (PC Code: 046612; CAS No.: 30968-43-5), 

does not have any registered products, is not being supported, and is not being addressed in this 

registration review. 1-(2-Hydroxyethyl)-2-alkyl-2-imidazoline (as in fatty acids of tall oil), 

hereafter referred to as alkyl imidazoline, is the only active ingredient in the case with any 

registered products. 

The first product containing alkyl imidazoline (PC Code 046609) as an active ingredient was 

registered in the United States in 1970. Currently, there is only one product containing alkyl 

imidazoline that is registered with EPA. The Agency completed a Reregistration Eligibility 

Decision (RED) for alkyl imidazoline in 1995. 
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Documents associated with the registration review of Alkyl imidazolines can be viewed at

www.regulations.gov in docket EPA-HQ-OPP-2011-0620. Below is a summary of the issues 

relevant to this registration review case.

Anticipated Risk Assessment and Data Needs:

The Agency anticipates the need to conduct a comprehensive ecological risk assessment, 

including an endangered species risk assessment, for all uses of alkyl imidazoline, and 

anticipates that additional data will be needed. However, the Agency does not anticipate the need 

to conduct a human health risk assessment for alkyl imidazoline.

Ecological Risk:

• No recent ecological risk assessment has been performed for alkyl imidazoline. 

• The Agency has not conducted a risk assessment that supports a complete endangered 

species determination for alkyl imidazoline. The ecological risk assessment planned 

during registration review will allow the Agency to determine whether alkyl 

imidazoline’s use has 'no effect' or 'may affect' federally listed threatened or endangered 

species (listed species) or their designated critical habitats. When an assessment 

concludes that a pesticide’s use 'may affect' a listed species or its designated critical 

habitat, the Agency will consult with the U.S. Fish and Wildlife Service and/or National 

Marine Fisheries Services (the Services), as appropriate.

• The Agency anticipates the need for the following additional ecological data for use in 

the registration review of alkyl imidazoline, including an endangered species risk 

assessment. These data were not required at the time of registration and are necessary to 

characterize the risk to aquatic organisms from the disposal of alkyl imidazoline-treated 

water residue down conventional drains.

o (GLN 850.2100) Acute Avian Oral Toxicity;

o (GLN 850.1010) Acute Freshwater Invertebrates Toxicity;

o (GLN 850.1075) Acute Freshwater Fish Toxicity; and

o (GLN 850.5400) algal toxicity (Tier II) using freshwater green alga, Selenastrum 

capricornutum.

• The Agency anticipates the need to require the following additional environmental fate 

data for use in the registration review of alkyl imidazoline. These data are necessary to 

complete a full down-the-drain environmental fate assessment.

o (GLN 835.2120) Hydrolysis;

o (GLN 835.2240) Photodegradation in water

o (GLN 850.6800) Modified Activated Sludge Respiration Inhibition1

 1 Based on the results of any required Activated Sludge Respiration Inhibition Test (ASRI), registrants 

may be able to request that EPA waive the requirements for additional biodegradation tests. If the ASRI 

test EC50 is less than or equal to 20 mg/L, registrants would need to perform one of 835.3220, 835.3240, 

or 835.3280. If the ASRI test EC50 is greater than 20 mg/L, registrants would need to perform either (i) 
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o (GLN 835.3110) Ready biodegradability

o (GLN 835.3220) Porous Pot Test

o (GLN 835.3240) Simulation Test – Aerobic Sewage Treatment: A. Activated 

Sludge Units

o (GLN 835.3280) Simulation Tests to Assess the Biodegradability of Chemicals 

Discharged to Wastewater.

• For more information, please refer to Summary of Product Chemistry, Environmental 

Fate, and Ecotoxicity Data for the 1-(2-Hydroxyethyl)-2-alkyl-2-imidazoline (as in fatty 

acids of tall oil) Registration Review Decision Document, located in the docket.

Human Health Risk:

• The most recent human health risk assessment for alkyl imidazoline was performed in 

support of the 1995 RED. The Agency does not anticipate the need for additional human 

health data at this time and does not anticipate that an updated risk assessment will be 

needed due to the limited potential for exposure.

For more information, please refer to Alkyl Imidazoline: Human Health Risk Assessment Scoping 

Document in Support of Registration Review, located in the docket.Product Chemistry:

• The Agency does not anticipate the need to require additional product chemistry data for 

this registration review case at this time.

• For more information, please refer to Summary of Product Chemistry, Environmental 

Fate, and Ecotoxicity Data for the 1-(2-Hydroxyethyl)-2-alkyl-2-imidazoline (as in fatty 

acids of tall oil) Registration Review Decision Document, located in the docket.

Endocrine Disruptor Screening Program

As required by FIFRA and FFDCA, EPA reviews numerous studies to assess potential adverse 

outcomes from exposure to chemicals. Collectively, these studies include acute, subchronic and 

chronic toxicity, including assessments of carcinogenicity, neurotoxicity, developmental, 

reproductive, and general or systemic toxicity. These studies include endpoints which may be 

susceptible to endocrine influence, including effects on endocrine target organ histopathology, 

organ weights, estrus cyclicity, sexual maturation, fertility, pregnancy rates, reproductive loss, 

and sex ratios in offspring. For ecological hazard assessments, EPA evaluates acute tests and 

chronic studies that assess growth, developmental and reproductive effects in different 

taxonomic groups. As part of its reregistration decision, EPA reviewed these data and selected 

the most sensitive endpoints for relevant risk assessment scenarios from the existing hazard 

 

835.3110 or (ii) one of 835.3220, 835.3240, or 835.3280. If the antimicrobial reaches pass levels for 

835.3110 (i.e., 70% removal of dissolved organic carbon (DOC) and 60% removal of theoretical oxygen 

demand (ThOD) or theoretical carbon dioxide (ThCO2) production for respirometric methods) in a 10-day 

window within the 28-day period of the test, registrants would be able to request that EPA waive the 

requirements for additional biodegradation tests. If the antimicrobial does not pass 835.3110, the 

registrants would need to perform one of 835.3220, 835.3240, or 835.3280.
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database. However, as required by FFDCA section 408(p), alkyl imidazoline is subject to the 

endocrine screening part of the Endocrine Disruptor Screening Program (EDSP). 

EPA has developed the EDSP to determine whether certain substances (including pesticide 

active and other ingredients) may have an effect in humans or wildlife similar to an effect 

produced by a “naturally occurring estrogen, or other such endocrine effects as the Administrator 

may designate.” The EDSP employs a two-tiered approach to making the statutorily required 

determinations. Tier 1 consists of a battery of 11 screening assays to identify the potential of a 

chemical substance to interact with the estrogen, androgen, or thyroid (E, A, or T) hormonal 

systems. Chemicals that go through Tier 1 screening and are found to have the potential to 

interact with E, A, or T hormonal systems will proceed to the next stage of the EDSP where EPA 

will determine which, if any, of the Tier 2 tests are necessary based on the available data. Tier 2 

testing is designed to identify any adverse endocrine-related effects caused by the substance, and 

establish a dose-response relationship between the dose and the E, A, or T effect.

Under FFDCA section 408(p), the Agency must screen all pesticide chemicals. Between October 

2009 and February 2010, EPA issued test orders/data call-ins for the first group of 67 chemicals, 

which contains 58 pesticide active ingredients and 9 inert ingredients. alkyl imidazoline is not 

among the group of 58 pesticide active ingredients on the initial list to be screened under the 

EDSP. Accordingly, as part of registration review, EPA will issue future EDSP orders/data callins, requiring the submission of EDSP screening assays for alkyl imidazoline . For further 

information on the status of the EDSP, the policies and procedures, the list of 67 chemicals, 

future lists, the test guidelines and the Tier 1 screening battery, please visit our website: 

http://www.epa.gov/endo/.
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Timeline

EPA has created the following estimated timeline for the completion of the alkyl imidazolines

registration review:

Anticipated Schedule

Activities Estimated Month/Year

Phase 1: Opening the docket

Open Public Comment Period for Docket September 2011

Close Public Comment Period for Docket November 2011

Phase 2: Case Development

Develop Final Work Plan (FWP) March 2012

Issue DCI March 2013

Data Submission March 2014

Open Public Comment Period for Preliminary Risk Assessments September 2015

Close Public Comment Period for Preliminary Risk Assessments November 2015

Phase 3: Registration Review Decision

Open Public Comment Period for Proposed Reg. Review Decision March 2016

Close Public Comment Period for Proposed Reg. Review Decision April 2016

Final Decision and Begin Post-Decision Follow-up 2016

Total (years) 5

Guidance for Commenters:

The public is invited to comment on EPA’s Preliminary Work Plan and rationale. The Agency 

will carefully consider all comments as well as any additional information or data provided in a 

timely manner prior to issuing a final work plan for the alkyl imidazolines registration review 

case.

Trade Irritants:

Through the registration review process, the Agency intends to solicit information on trade 

irritants and, to the extent feasible, take steps toward facilitating irritant resolution. Growers and 

other stakeholders are asked to comment on any trade irritant issues resulting from lack of 

Maximum Residue Limits (MRLs) or disparities between U.S. tolerances and MRLs in key 

export markets, providing as much specificity as possible regarding the nature of the concern. 

Water Quality:

Alkyl imidazoline is not identified as a cause of impairment for any water bodies listed as 

impaired under section 303(d) of the Clean Water Act, based on information provided at 

http://iaspub.epa.gov/tmdl_waters10/attains_nation_cy.cause_detail_303d?p_cause_group_id=88

5. In addition, no Total Maximum Daily Loads (TMDL) have been developed for alkyl 

imidazoline, based on information provided at 
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http://iaspub.epa.gov/tmdl_waters10/attains_nation.tmdl_pollutant_detail?p_pollutant_group_id

=885&p_pollutant_group_name=PESTICIDES.

More information on impaired water bodies and TMDLs can be found at 

http://www.epa.gov/owow/tmdl/. The Agency invites submission of water quality data for this 

pesticide. To the extent possible, data should conform to the quality standards in Appendix A of 

the OPP Standard Operating Procedure: Inclusion of Impaired Water Body and Other Water 

Quality Data in OPP’s Registration Review Risk Assessment and Management Process (see:

http://www.epa.gov/oppsrrd1/registration_review/water_quality_sop.htm), in order to ensure the 

data can be used quantitatively or qualitatively in pesticide risk assessments.

Environmental Justice:

EPA seeks to achieve environmental justice, the fair treatment and meaningful involvement of all 

people, regardless of race, color, national origin, or income, in the development, implementation, 

and enforcement of environmental laws, regulations, and policies. To help address potential 

environmental justice issues, the Agency seeks information on any groups or segments of the 

population who, as a result of their location, cultural practices, or other factors, may have 

atypical, unusually high exposure to alkyl imidazoline compared to the general population. 

Please comment if you are aware of any sub-populations that may have atypical, unusually high 

exposure compared to the general population.

Structure Activity Relationships:

EPA must rely upon information of appropriate quality and reliability for each decision made by 

the Agency. In the Office of Pesticide Programs (OPP), the evaluation process for a pesticide 

chemical traditionally begins with the applicant’s submission of a set of studies conducted with 

the specific pesticide chemical of interest. The use of the results of such testing (measured data) 

is a logical, scientifically rigorous process that identifies the physical, chemical, and 

environmental fate properties of the pesticide, as well as the dose and endpoints at which an 

adverse effect can occur in various animal species. 

Today, there is significant interest in alternative techniques, i.e., techniques other than data 

generation that could significantly inform the Agency’s decision-making process. Recently, OPP 

has made increasing use of structure activity relationship (SAR) as part of its regulatory 

decision-making process. In the SAR process, a chemical's molecular structure is compared to 

that of other chemicals for which data are available. These structural similarities are then used to 

make predictive judgments about a chemical’s physical, chemical, and biological properties. 

Thus, the chemical’s physical, chemical, and biological properties are a function of (or directly 

related to) the chemical’s molecular structure. Quantitative SAR is referred to as QSAR. To 

develop a QSAR, a selected set of measured data on a single physical, chemical, or biological 

property is used to derive a model (an equation) to predict the value of that property. 

Since SAR assessments and QSAR modeling are another set of tools that are available to Agency 

scientists, OPP has begun a process shift that envisions shifting from the current study-by-study 

approach to an approach in which the use of predicted data, generated using validated models, is 

considered along with information from open literature and studies specifically generated under 
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Part 161 requirements. All relevant information would be considered as part of a weight-of-theevidence evaluation. 

At this time, EPA believes that for certain endpoints, especially physical/chemical and fate 

properties, that SAR and QSAR might be effectively utilized to fulfill these data requirements 

for many antimicrobial pesticide chemicals. When considering biological properties, at this time, 

EPA believes that SAR and QSAR can be most effectively utilized in the evaluation of 

chemicals that exhibit lower toxicity for human health and/or ecotoxicity parameters. This is 

appropriate because the risk assessment for lower toxicity chemicals can be stream-lined, i.e., a 

screening-level assessment procedure rather than multiple tiers of assessments with progressively 

more data requirements.

If stakeholders believe that submission of predicted data can fulfill one of the data needs for the 

alkyl imidazolines case, then the Agency invites submission of this information. The submitter 

would be expected to supply a rationale describing the utility of the information and provide 

documentation on the scientific validity of the information. The determination that the predicted 

data fulfills the data requirement would be at the sole discretion of the Agency. Pre-submission 

consultation with the Agency is encouraged.

Additional Information:

Stakeholders are also specifically asked to provide available information and data that will assist 

the Agency in refining its risk assessments, including any species-specific ecological effects 

determinations. The Agency is interested in receiving the following information:

1. Confirmation on the following label information:

a. Sites of application

b. Formulations

c. Application methods and equipment

d. Maximum application rates

e. Frequency of application, application intervals and maximum number of 

applications

f. Geographic limitations on use

2. Use or potential use distribution

3. Use history

4. Usage/use information for non-agricultural uses (e.g., materials preservation)

5. Typical application interval

6. State or local use restrictions

7. Ecological incidents (non-target plant damage and avian, fish, reptilian, amphibian 

and mammalian mortalities) not already reported to the Agency

8. Monitoring data

Next Steps:

After the 60-day comment period closes in November 2011, the Agency will review and respond 

to any comments received in a timely manner, and then issue a Final Work Plan for the alkyl 

imidazolines case. 
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II. Fact Sheet

Background Information:

• Active Ingredient: Alkyl Imidazoline

• Case number: 3010

• PC Code: 046609

• CAS number: 61791-39-7

• Technical registrants: Nalco Energy Services

• First approved for use in a registered product: 1970

• Antimicrobials Division Chemical Review Manager (CRM): Eliza Blair, 

blair.eliza@epa.gov

• Antimicrobials Division Product Manager (PM): Marshall Swindell, 

swindell.marshall@epa.gov

• Chemical Structure:

Use & Usage Information:

• Alkyl imidazoline is a microbiocide/microbiostat registered for use in fuel and oil storage 

tank bottom water. The product containing alkyl imidazoline is registered for use to 

prevent the growth of slime-forming bacteria and fungi which might interfere with the 

use and quality of oils and fuels in storage tanks. There is one soluble concentrate liquid 

product, with 25% active ingredient. The product is loaded and applied through a closed 

delivery system that has a proportioning pump or siphon type feeder to meter the 

pesticide product directly from the product container into the fuel oil as it is pumped into 

storage tanks. The product is not registered for homeowner use or for use in or around 

residences.

Recent/Pending Regulatory Actions:

• No recent or pending regulatory actions exist for alkyl imidazoline.

Ecological Risk Assessment Status:

Please refer to Summary of Product Chemistry, Environmental Fate, and Ecotoxicity Data for 

the 1-(2-Hydroxyethyl)-2-alkyl-2-imidazoline (as in fatty acids of tall oil) Registration Review 

Decision Document, located in the docket, for a detailed discussion of the ecological risk 

assessments.

• The Agency has not conducted an ecological and environmental fate assessment for alkyl 

imidazoline. The Agency needs to conduct environmental fate and ecological risk 

assessments for alkyl imidazoline’s use as a fuel oil treatment. For use in the planned 

ecological risk assessment, including an endangered species assessment, the Agency 

anticipates needing ecological effects data to characterize alkyl imidazoline’s toxicity to

birds, fish, and aquatic invertebrates.
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• The Agency has not conducted a risk assessment for alkyl imidazoline that supports a 

complete endangered species effects determination. The ecological risk assessment 

planned during registration review will allow the Agency to determine whether alkyl 

imidazoline use has “no effect” or “may affect” federally listed threatened or endangered 

species (listed species) or their designated critical habitats. When an assessment 

concludes that a pesticide’s use “may affect” a listed species or its designated critical 

habitat, the Agency will consult with the U.S. Fish and Wildlife Service and/or National 

Marine Fisheries Services (the Services), as appropriate.

Human Health Risk Assessment Status:

Please refer to Alkyl Imidazoline: Human Health Risk Assessment Scoping Document in Support 

of Registration Review, located in the docket, for a detailed discussion of the human health risk 

assessment.

Hazard Characterization:

• Alkyl imidazoline's sole registered use as a fuel oil preservative, and the fact that it is 

required by the label to be mixed via closed system at industrial sites, make the potential 

for human exposure small.

Dietary (Food and Water):

• Dietary and drinking water exposures to alkyl imidazoline have not been assessed and are 

not anticipated because of the use pattern which is limited to fuel storage tanks. Because 

alkyl imidazoline has an octanol water coefficient of 28,500, it will partition to the oil 

phase of the treated fuel and it will remain in the oil phase if the treated fuel contaminates 

drinking water. It is likely therefore, the oil itself will contaminate the drinking water 

and cause odor and taste problems long before alkyl imidazoline will reach significant 

levels.

Residential:

• Residential exposures to alkyl imidazoline have not been assessed and are not anticipated 

because it is registered for use only in industrial fuel storage facilities.

Aggregate:

• The Agency has not conducted an aggregate risk assessment for alkyl imidazoline. 

• In examining aggregate exposure, EPA takes into account the available and reliable 

information concerning exposures to pesticide residues in food and drinking water, as 

well as non-occupational pesticide exposures. An aggregate risk assessment has not been 

deemed necessary for alkyl imidazoline because of the limited use patterns and limited 

potential for exposure.
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Occupational:

• Occupational handler exposures were assessed in the 1995 RED for the mixing and 

loading for the fuel preservation use. The MOEs were calculated for “total exposures” 

based on the addition of the dermal and inhalation exposures and were assessed using the 

oral endpoint of 15 mg/kg/day along with a dermal absorption factor of 100 percent and a 

daily fuel treatment volume of 10,000 gallons. All of the MOEs were above the target 

MOE of 100 and, therefore, were not considered to be of concern. 

• No occupational exposure assessments are needed if the current label requirement for 

closed system use is maintained.

Cumulative:

• Unlike other pesticides for which EPA has followed a cumulative risk approach based on 

a common mechanism of toxicity, EPA has not made a common mechanism of toxicity 

finding as to alkyl imidazoline and any other substances and alkyl imidazoline does not 

appear to produce a toxic metabolite produced by other substances. For the purposes of 

this registration review action, therefore, EPA has not assumed that alkyl imidazoline has 

a common mechanism of toxicity with other substances. For information regarding 

EPA’s efforts to determine which chemicals have a common mechanism of toxicity and 

to evaluate the cumulative effects of such chemicals, see the policy statements released 

by EPA’s Office of Pesticide Programs concerning common mechanism determinations 

and procedures for cumulating effects from substances found to have a common 

mechanism on EPA’s website at http://www.epa.gov/pesticides/cumulative/.

Incidents:

Ecological:

• No alkyl imidazoline ecological incidents have been reported in the OPP incident 

database.

Human Health:

• No alkyl imidazoline human poisoning incidents have been reported in the OPP incident 

database.

Tolerances and International Harmonization:

• No tolerances or exemptions from tolerances have been established for alkyl imidazoline. 

Alkyl imidazoline is not approved for use as an indirect food additive. 

Data Call-In Status:

• No recent data call-in has been issued for alkyl imidazoline.

Labels:
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Registered products, including EPA registration numbers are provided in Table 1 below. For 

future reference, during registration review a list of product registration numbers will be included 

in the docket. Product registration labels may be obtained from the Pesticide Product Label 

System (PPLS) website at: http://oaspub.epa.gov/pestlabl/ppls.home.

Table 1. Registered Products –

Registration

No. Registration Name CompanyName

Formulation 

Type

% of Active

Ingredient

68708-3 NALCO 2210

Fuel Oil Treatment

Nalco Energy Services, 

L.P.

Ready-to-use 

Solution 25

III. Summary of Anticipated Data Requirements – Alkyl Imidazolines

The table below summarizes anticipated data needs for the Alkyl Imidazolines Case in Section I 

of this document (Preliminary Work Plan), Summary of Product Chemistry, Environmental Fate, 

and Ecotoxicity Data for the 1-(2-Hydroxyethyl)-2-alkyl-2-imidazoline (as in fatty acids of tall 

oil) Registration Review Decision Document, and Alkyl Imidazoline: Human Health Risk 

Assessment Scoping Document in Support of Registration Review.

Table 2. Summary of Anticipated Data Requirements –

Guideline

Number Anticipated Data Requirement Test Material

Estimated Timeframe 

(Measured in months from 

DCI Receipt)

835.2120 Hydrolysis TGAI 12

835.2240 Photodegradation in Water TGAI 12

850.6800 Modified Activated Sludge Respiration 

Inhibition TGAI 12

835.3110 Ready biodegradability TGAI 12

835.3220 Porous Pot Test TGAI 12

835.3240 Simulation Test – Aerobic Sewage 

Treatment: A. Activated Sludge Units TGAI 12

835.3280

Simulation Tests to Assess the 

Biodegradability of Chemicals 

Discharged to Wastewater

TGAI 12

850.2100 Acute Avian Oral Toxicity TGAI 12

850.1010 Acute Freshwater Invertebrates Toxicity TGAI 12

850.1075 Acute Freshwater Fish Toxicity TGAI 12

850.5400 Algal Toxicity using freshwater green TGAI 12
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alga, Selenastrum capricornutum
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IV. Appendix A: Use Patterns – Alkyl imidazolines

Use Site Formulation/

EPA Reg. 

no.

Method of 

Application

Application Rate/ No. of applications Use 

Limitations

Hydrocarbon 

fuel 

preservative

68708-3 Metering 

pump

For use with closed delivery systems only. 

Use 40 to 80 ppm of 2210 Fuel Oil Treatment 

based on fuel oil. Feed 2210 Fuel Oil 

Treatment by means of proportioning pump 

or siphon type feeder directly from drum or 

other container to the fuel oil as it is pumped 

into storage tanks.

Not for 

individual use 

or use near 

residences.