CONTRACT
      TO SUPPLY ACTIVE INGREDIENTS

    


    


    


    Between:

    


    
      	
              §

            	
              SIRTON
                PHARMACEUTICALS S.p.A
                ,
                whose registered office is in Villa Guardia (CO), Piazza XX Settembre
                nr.
                2, Tax Code 01192270138, represented by dr. Laura Iris Ferro, Deputy
                Chairwoman (hereinafter referred to as SIRTON)
                

            


    

    


    AND

    


    
      	
              §

            	
              GENTIUM
                S.p.A. ,
                whose registered office is in Villa Guardia (CO), Piazza XX Settembre
                nr.
                2. Tax Code 02098100130, represented by dr. Salvatore Calabrese,
                Director
                of Administration (hereinafter referred to as GENTIUM);

            


    

    


    WHEREAS:

    


    
      	
              §

            	
              GENTIUM
                produces
                and sells active ingredients for pharmaceutical use and raw materials
                for
                pharmaceutical use; 

            


    

    


    
      	
              §

            	
              SIRTON
                uses said active ingredients to produce specialty pharmaceutical
                products

            


    

    


    


    NOW,
      THEREFORE, THE PARTIES AGREE AS FOLLOWS: 

    


    
      	
              1.

            	
              GENTIUM
                undertakes
                to supply SIRTON with its active ingredients on the basis of standard
                purchase orders issued by SIRTON;

            


    

    


    
      	
              2.

            	
              SIRTON
                undertakes
                to provide GENTIUM with purchase orders three months before the date
                envisaged for the supply of such as well as purchase forecasts for
                rolling
                12 month periods on the basis of which GENTIUM may plan its production
                activities;

            


    

    


    
      	
              3.

            	
              The
                sale price of each active ingredient will be established as indicated
                in
                attachment “A” to this contract. 

            


    

    


    
      
         

      

      
         

        
          

        

      

      
         

      

    

    


    
      	
              4.

            	
              SIRTON
                undertakes to pay the agreed amounts on submission of standard invoices
                and will pay via direct bank transfer 60 days from the end of the
                month in
                which the invoice is dated. 

            


    

    


    
      	
              5

            	
              The
                contract will be effective as of 02/01/2006 and will expire on 31/12/2006
                and will be considered tacitly renewed from year to year unless one
                of the
                parties gives notice to the other, sent at least one month prior
                to
                expiry.

            


    

    


    
      	
              4.

            	
              The
                Parties reserve the right to revise the contractual conditions on
                expiry
                or during the life of the contract if there are any significant changes
                to
                the services rendered or the cost of such.


            


    

    The
      Parties shall have the right to withdraw from the contract if the revised
      conditions are not accepted.

    


    
      	
              5.

            	
              The
                Parties acknowledge, with immediate effect, the right to negotiate
                variations of the fees established above on the basis of the actual
                amount
                of services rendered.

            


    

    


    
      	
              6.

            	
              All
                correspondence regarding this Contract must be made in writing and
                sent by
                hand, by fax, telegram or registered mail with return receipt to
                the
                registered office of each Party.

            


    

    


    
      	
              7.

            	
              Any
                dispute regarding this Contract will be settled by a Board of Arbitration;
                each of the Parties will nominate its own arbitrator, who in turn
                will
                choose the third member of the Board of Arbitration, who will act
                as
                Chairman of said Board.

            


    

    


    
      	
              8.

            	
              This
                Contract cancels and replaces all previous service provision agreements
                between the Parties and may not be amended or changed in any way
                with the
                exception of that expressly provided for herein or with the written
                agreement of the Parties signed by their authorised
                representatives.

            


    

    


    Read,
      confirmed and signed.

    


    Villa
      Guardia, 2 January 2006

    


    
      	 	 	 	 
	/s/ Laura
              Iris Ferro	 	 	/s/ Salvatore
              Calabrese  
	
              
Sirton
              Pharmaceuticals S.p.A	 	 	
              
Gentium
              S.p.A.
	
              Deputy
                Chairwoman   

               (dr.
                Laura Iris Ferro)

            	 	 	
              Director
                of
                Administration

              (dr. Salvatore
                Calabrese)