### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C

. 20460 OFFICE OF CHEMICAL SAFETY A ND POLLUTION PREVE NT I ON



### M E MORAND UM Date: 05 /25 /20 15 SUB JE C T: Halo s ulfuron-M cth y l. 

### Acute and Chronic Aggregate Di e tary (Foo d and Drinking Water) Ex pos ure and Ri sk Assess m ents for th e Sec ti o n 3 R eg is trat ion Ac ti o n on Pom c Fruit Group 11

- 10 

### and Frnit, S mall Vine Climbin g Subgroup 13-07F. P C Co d e : 128721 Decis io n No.: 493338 Petiti o n No.: 4 E8 297 DP B a rcocl e: 0426724 R eg i st r a ti o n No
. : 81880-18 and 81880

- 2 R eg ul ato r y Ac tion: Sectio n 3 Reg is tratio n Case No. : NIA Ri s k Assess m e n t Typ e : Dietar y TXR No
. : NI A CAS No.: I00784

- 20-1 4 0 CFR : § 180.479 MRID No.: NIA 

### F ROM :

THRO UG H:

TO: 

### Kri s tin Rury, Bi o logi s t

# y_Q~ Ri sk Assessment Branch Jir 

# (RABJ) L) Health Effec ts Division (7509 P)


### Doug Dotson , Chemist 

# J
.**~~** - tf!J. 

### 11.

.... 

### S umitraB oseBiswas,Che mi st
-**~ p·PQ>~**  

### D ie tary Expos ure Sc ience Adv iso r y Cou ncil ( DESAC) Kristin Rury , Risk Assessor ; / / / , Ri s k Assessment Branch HI (RABJ)

## _;t~ Hea lth Effe c ts Di vis io n (7509 P)

- 

### and S idn ey Jackson , Ri sk Man ager R ev iewe r Barbara Madden , Risk Manager Minor Use and Em e rgency Response Branch Re gi s trat ion Di vis io n (7505P) E xec uti ve S ummary

Page I of 13Halosul furon-Methyl Dietary Ex po s ure and Ri sk Assessment DP Number: D426724


### Acute and ch r onic aggregate dietary (food and drinking water) exposure and risk assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commod ity Int ake D atabase (DEEM- FC ID ) Version 3.16. This softwa r e uses 2003-2008 food consumption data from the U
. S. Department of Agriculture's (USDA's) National Health and Nutriti on Examination Survey , What We Eat in America, (NHANES/WWEIA )
. The analyses were conducted in sup port of a hum a n-h ea lth risk assessment for th e proposed Section 3 uses of halosulfuron-methyl on P ome Fruit Group 11-1 0 and Fruit, Small Vine Climbing Subgroup 1 3

- 07F. This memorandum was r ev iewed by tw o peer reviewers of th e D ESAC, per DESAC SOP 20 12. 1. Unrefined ac ute (females 13-49 years old) and chronic dietary (food and drinking water) exposure assessme nt s were conducted for the curre ntl y registered and proposed new uses on Pom e Fruit Group 11-10 and fruit , Sma ll Vine Climb in g S ub group 13-07F. There were no appropriate toxicological effects attributable to a single exposure (dose) for the general population or any other population subgro ups except females 13-4 9 years old; therefore , these population subgroups were not included in the acute dietary assessment. The acute (females 13- 49 years old) and chronic dietary assessments included tolerance-l eve l res idu es for all commod iti es and assumed 100 % crop treated (CT) for all crops. Modeled drinking water estimates were provided by the Environmenta l Fat e and Effects Di v ision (EFED). DEEM version 7.81 default processing factors were assumed except for where tolerances we re established for processed commodities or when processing studies showed no concentration. Modeled estimated drinking water concentrations were included in the assessme nt. Acute Dietary Exposure Assessment There was no indication of an adverse effect attributable to a single dose for the general U.S. population. H oweve r, an acute reference dose (aRfD) was es tabli shed for females 1 3-49 years old
. Therefore , an acute dietary exposu re assessment was only conducted for females 13-49 years o ld
. The unrefined acute dietary exposure estimate at the 95 111 

### percentile i s < l % of the acu te population adjusted dose (a PAD) for females 13-49 years old. C hronic Dietary Exposure Assessment The unrefined chronic dietary (food and drinking water) exposure to halosulfuron-methyl is below HED 's leve l of concern (<100% of the chronic population adjusted dose (cPAD)) for the general U.S. population and all population subgroups. The chronic dietary exposure estimates are 2.1 % of the c PAD for the gene r a l U.S. population and 5.7% of the cPAD for children 1- 2 years old, the most hi gh ly exposed population subgroup. Canc er Dietary Expos ure Assessment Halosulfuron-methyl is classified as " not likely to be a human carcinogen;" therefore , quantification of human cancer risk is not required. I. 

### Intro du ctio n Halosulfuron-methyl is a se l ective herbicide belonging to the sulfonylu rea g ro up of herbicid es, which inhibits th e action of acetolacetate synthase enzyme, a s peci lie plant enzyme.

Page 2of13Halo sul furo n-M eth y l Di etary Expo s ure and Ri sk Asse ss m ent DP Number: D426724


### I-Ialo s ulfuron-me thyl i s u sed fo r the pre- an d postemergence control of ann u al b road leaf w ee ds an d nut se dg es o n various agricultural crops, as we ll as on residentia l turf g ra ss and ornamenta ls . Di eta r y ri sk assess m e nt inc o rpora t es b o th ex po su re and tox icity of a g iven pest i c ide. For ac ute and ch ro nic assess m ents, the ri sk is expressed as a perc e ntage of a maximum acceptable d ose ( i. e . , the dose th at H ED has concluded w ill result in no unreasonable adverse health effec ts). T hi s dose is refer red to as the p op ulation- a dju s te d dos e (PAD)
. The PAD is equ iv a le nt to th e po int of departure (POD. no observed adverse effect le ve l (NOAEL), lo wes t observed adv e rse effect level (LOAEL), e.g.) divided by the require d unc e rtainty o r safety factors
. For acute and non - can ce r chron ic exp osures, HED is conce rn ed w hen estimated di e tary risk exceeds I 00% of the P A D. R efere nces th at di sc u ss the acute and c hronic ri s k assess ment s in more deta il a re ava il ab le o n th e E PA / p est ic ides web site: " Available In format io n on Asse ss in g Exposu re from Pes ti cides , A Use r 's G uide , " 2 l-J UN

- 2000 , web link: http: //www.reg ul at io n s.gov/# ! docu mentDeta il:D = E PA-HQ-OPP- 2007

- 0780 -00 0 I ; or see SO P 99
. 6 (20- AUG-1999). The most r ece nt die tary ri s k assessme nt for halo s ulfuron-methy l was conducted b y Mehere t Neg u ss ie (D 4056 60 , 03 /2 5/ 20 1 3)
. II. Re s idue Information T he Interregi o n al Re sea rc h P roject No. 4 (IR-4 ) has prop ose d new uses of ha l osu l furon -m eth y l o n Pome Fruit Group 11-10 and Fruit, S mall Vi ne C limbin g S ubgrou p I 3-07 F. P e rm a nent tolera nces arc es ta bli s hed und e r § J 

### 80.479(a)( I ) fo r re s idu es of halos ulfuron -meth y l and it s metabolites determ ined as 3

- c hl oro -l-m cthy l- 5-su l famoy lpyrazo le -4-carb oxy li c acid (3

- CSA), exp r essed as ha los ulfuron-meth y l e quivalents , at level s rang in g from 0
. 05 ppm ( milk , fat a nd meat) to 1.0 ppm (meat byproducts) of catt le , goat, ho g, horse, an d s he ep. To l erances are estab li shed und e r § 18 0.479(a)(2) fo r re s idues o f ha losulfuron-mcth y l in/on a vari e ty of field , fruit, and vege tab le crop commod it i es at leve ls r a nging from 0
. 05 to 20 ppm. The H ea lth Effects Di vis ion ( H E D ) ha s conclu ded that th e resid ue of concern for tolerance e nforce ment and ri sk assessment in target plants a nd rotational plants i s h a los ulfu ro n-me th y l (G. 

### J. Herndon , No DP , 09/ 16/1993 a nd 05 /2 1 / 199 6). H E D previo u s ly has concluded th at the r es idue of conce rn in rumin a nt s is ha los ulfuron -me thyl. Howev e r, because the a pprov ed e nforce m e nt m etho d for livestock co mm od it ies qu antifi es the paren t co mp ound and m e tabo lites co nt a i ni ng th e 3 -CSA m o iety 

### by co n verting residues to 3

- CSA , to le r ances for residues of pare nt and its m e tabo lites in li vestock commoditie s a re determined as 3-CSA, ex p r essed in halo s ulfuron

- m eth y l equiva le nt s. T he res idue of co ncern in water is ha losu lfuron-met hyl. Residue Data u sed for Acute and C hron ic Assessments:

Page 3of13Halosu If uron-Methyl Dietary Exposure and Risk Assessment DP Number: 04 26724
The acute and c lu ·onic assessments a r e unre fin ed assessments using tolerance-level residues and I 

### 00% CT for all commodities. Additionally, DEEM version 

### 7
. 81 default process i ng factors were assumed except for where tolerances were es tab li shed for processed commodities o r when processing s tudi es s howed no co ncentratio n. Based on proce ss ing studies, the proces sing factors were reduced to l for to m ato paste, tomato puree , potato flour , and potato granu l es/flakes. The USDA Pesticide Data Program ( PDP ) monitored pe st icide residue s in catfish in 

### 2008, 2009, and 

### 2010. In genera l, pesticide residues wou ld not be expec ted to be fo und in fish unl ess the pest icide b ioaccumulates or ha s an aquatic use. To determine whether or not residues are present in fish, HED now routi ne ly ch ec ks PDP monitoring data r egard le ss of th e pesticide 's u ses and physicochemical properti es . However, PDP d id not analyze catfi sh samples for halosulfuronmethy l. As a re su lt , residues in fish were not included in the assessmen t. Table 

### 1 i s a summary of the H E D recommended food tolerances res ulting from the proposed uses 

### ( 04 26614).

Tab l e 1- 

### To lerance S u mmary for the New Uses for Hal osu lf uro n-Met hyl. Reco mme nded Tolerances Co mmodity Use d i n t he Acute and Chronic Analyses (ppm) Po rn c Fru it Group 11-10 0.05 

### Fruit , Sma ll V in e C limbing Subgroup 13-07F 0.05 

### Il l. Percent C rop Treated Informat i on T he ac ute an d c hroni c dieta ry expos ure assess m e nt s ass umed that 

### 100% of the proposed and registered crops were treated with halosulfuron-meth y l ( 

### 100 % CT). 

### IV. Dri nking Water Data T ier I est im ated surface and grou nd water estimated drinking water concentrations (EDWC s) were eva luated for the proposed new use s of halosulfuron-methyl. The hi g hest EDWCs cont inu e to be from the existi ng u se o n rice, even with eva lu ating the proposed and existing use s using the Pesticide Roo t Zone Model

- Ground Water (PRZM-GW ) (M. Barret, 

### 042 1 820, 04/ 1 5/ 2015). Water residues were incorporate d in the DEEM-FC J D into the food categor ies "wa ter , direct, all so urces " and "wate r , indirec t , all sources.'· The Tie r I EDWCs for halosulfuron-me thyl are ba sed on a maximum annual application rate of 

### 0. 125 lb ai/ A for ric e. T he two screening models , th e Food Quality Protect ion Act (FQPA) Index Re sevo ir Screeni n g Tool (FIRST) and Screening Co ncentrations in Ground Wate r (SC IGROW), were used for estimating E DWCs of h a losu lfu ron -me th y l. Estimates fo r halo s ulfuronm ethy l in su rface wate r based o n the FIRST model for ri ce are 

### 59
. 2 ppb for both acute and chronic concentrations. The drinking water esti m ate based on rice application is an upper bound estima te. The es tim ate fo r hal os ul f uron-meth y l in grou nd wate r ba se d on the SC I- G R OW model res ult is 

### 0.065 ppb. Tab le 

### 2 summarizes the results.
Page 4of13Halo sul furo n-M ethy l Dietary Exposure and Ri sk Assessment DP Number: D4 26724

Table 2. S umma ry o f Esti m ate d S urf ace Water a nd G roundw ate r Co nce ntra ti o n s for H a los ulfuro n- m e thyl. Duratio n S urf ace Wate r Cone., ppb a G roundwate r Co ne. , ppbb Acute 59.2 0.065 C hro ni c ( non- ca nc e r) 59.2 0
. 06 5 • Fr o m the P IRS T m odel. b Fro m the SC I- GR O W model. The drinking wate r mod e l s and their de sc riptions are ava ilable at the EPA internet s ite: http ://www.epa.gov/ oppefed 

### I / models/wa te r /
. 

### V. DEEM-FCID Program and Consumption Inform a tion H a losu lfuron-me th y l acute and chron ic di e tary exposure assessments were conducted using the DE E M-FCID , V e rsion 

### 3. 1 6 , which incorporates 

### 2003-2008 consumption data from USDA' s N HANES / WW E T A. The dat a are based o n th e reported consumption of more than 

### 20,000 individuals over tw o non-consec uti ve survey days. Fo ods " as consumed " (e
. g ., apple pie) are link e d to EPA-d efi ne d food commodities (e
. g., apples , peeled fruit

- coo k e d ; fresh or N / S; b ake d ; o r wheat flour

- cooked; fresh or N / S, bake d) using publicly avai lab l e r ec ip e tran s lat ion files developed jointl y by U SD A/ ARS and EPA. For chronic exposu re assessment , consumption d ata are averaged for th e e ntire U
. S. population a nd within population s ub gro up s. H owever , for acute expo s ure assess m en t , consumption data are ret a i ned as indi v idual consumption eve nts. Based o n a n a l ys is of the 

### 2003 -2008 WWEIA con s umption data , wh i c h took into account dietary pattern s and s urvey respondents , HED concl ud ed that it is mo s t approp riate to report risk for the fo ll ow ing population subgroups: the genera l U.S. population , all infant s (< 1 year o ld) , children 

### 1-2 , ch ildren 

### 3

- 5 , c hildren 

### 6 -1 2 , you th 

### 13-19 , a dult s 

### 20-49 , females 

### 1 3 -49 , and adults 

### 50

- 99 year s old
. Fo r a chronic di e tary exposure assess ment , an est im ate of the re s idue level in eac h food or foodform (e.g., orange o r orange juice) on th e food commodity res idu e li st i s multipli ed by the average da i ly cons umption es tim ate for that food/food form to produce a re s idu e intake es tim ate. The res ulting re s idue intake es timate for eac h food / food form i s summed with th e r es idu e intake estima tes for a ll other food/food forms on the commod ity residue li s t to arrive at th e total average est imate d ex posure . Exposure i s ex pre sse d in m g/ kg bod y weight/day a nd as a percent of the c PA D. This procedure is p e rfom1 ed for e ach population subgro up. Fo r a n ac ute exposu re asse ss m e nt, individual o ne -d ay food consump tion data are u se d on an indi v idu a l-by-indi v idual ba s i s . The report e d consumpt io n amounts of eac h food ite m can be multiplied by a residue point est i mate and su mmed to o bta in a total d a il y pesti c id e exposure for a deterministic exposu re assessment , or " matc he d " in multipl e rand om p a iring s w ith re s idu e va lu es a nd th e n s umm ed in a probabili s ti c as sess m e nt. The res ulting di s tribution of exposures is exp resse d as a percentage of the aPA D on both a use r ( i. e., on ly tho se who repor1 e d eating relevant co mmod iti es/ food forms) and a per-capita (i.e., tho se who r e p o rted eating the rele van t commodi ti es as we ll as th ose who did not) basis. In acco rdance w i th HED policy , per capita
Page 5of13Halosulfuron-Methy l Dietary Exposure and Ri s k Assessment DP Number: D426724



### expo sure and risk are repo rted fo r ana lyses performed at a ll levels of refinement. However , for dete rmin is ti c assess me nt s, an y s ig nifi cant d ifferences in u ser vs. per capita exposure a nd risk are specific all y identified and noted in the risk assessment. VI. Toxicological Information 

### The risk assessment team confirmed endpoints that were previous ly selected, and co nfi rmed th e reduction to IX of the FQPA Safety Factor fo r all population subgroups (W. Phang, 0358031 , 06/ 30 / 2009). Toxicolog ical endpo in ts for u se in d ie tary expos ure ri sk assessments are s umm ar ize d in Tab le 3 below. Tab le 3. S umm ary of Toxicological Do ses and End point s for H a losulfuron-metbyl for Use in Di e tary Ex po s ure Ri s k Assessme nt s. Exposure/ Point of U nc e rtainty/FQPA 

### RID , PAD , Level of S tud y a nd To xicolo g ical E ffects Sce nario D ep arture Safety Factors Co nc e rn Acute RID Devel o pm e nt a l Toxicity

- Rabbit Acute = 0.5 LOA EL = 150 mg/kg/day based on Dietary NOA EL= UFt.= IOx mg/kg/day decreased m ean I itter size, (Females 

# so UF11= I Ox increased number of resorp t ions 13-49 years mg/kg/day FQ PA SF= Ix a PAD = 0.5 ( tota l a nd per dam) and increased of age) mg/kg/day postimplantation lo ss. (deve lopme nta l toxicity) Acute D i eta r y No adverse effect attributable t o a s in gle dose was identified; th erefore, no dose/endpoint was (Ge neral selected for this exposur e sce n ari o. [A lthough th e acute neurotoxicity li sted in th e Toxicity Population , Profile (Appendix A) showed a death occurred in this study, the death was not considered to inc lu ding be treatment related a nd occurred at I 000 m g/kg/ day where no compound r elated effect was In fants and seen] Children) C hroni c RfD = 0.1 C hronic Toxicity

- Dog Chron i c NOAEL= UFA=IOx mg/kg/day Dietary (All 10 UFH= IOx LOA EL = 40 mg/kg/day based on Population s) mg/kg/clay FQ PA SF= Ix c PAD = decreased body weight gains in 0.1 fema l es. mg/kg/day Cancer (oral, C la ss ifi cation : " not likely to be carc ino ge nic to hum ans" by the oral route, based dermal , o n n o ev id ence of carc in ogen i c i

ty fro m studies in rats and mice
. inhalat i on) Point of Departure (POD) = A data point or an es timated point that is derived from observed dose-response data and used to mark the beg inning of' extrapo lati on to determine risk associated wi th l ower environ m enta ll y relevant human exposures. NOA EL = no observed adverse effect level. LOA EL = lowes t observed adverse effect level. 

### ur = uncertainty factor. 

### ur A= extrapolation from animal to human (interspecies). UF11 = potential variation in se nsiti vi ty among members of the human population (in traspecics). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chro nic). RID = reference do s e. NIA = not applicable
.

Page 6of13Halo s ulfuron

- Methyl Dietary Exposure and Ri sk Assessment DP Number: 0 426724
VII. Re s u l ts/D i sc u ss i on As slated above , fo r acu te and ch r o nic assess m e nt s, H ED is conce rn ed when dietary risk exceeds 100% of the P A D
. T he DE E M- FC ID analyses estimate th e dietary ex posure and ri sk of th e 

### U.S. populat io n and va ri o u s population subgro ups . T he resu lt s repo rted i n Tab le 4 are for the ge ne ral 

### U .S. Population , a ll infan ts( < ! year old) , childre n l-2 , childre n 3-5 , c hildre n 6-12 , youth 13-19 , female s 13-49 , adults 20-49 , and adults 50-99 years. Results of the Ac ute Di etary (r ood and Drinkina Wate r) Ex p os ure Assess m e nt There was no indication of an adverse effect attributab le to a single dose fo r the genera l 

### U.S. populatio n. H owever , an aRfD was establi s hed for females I 3

- 49 years o ld , a n d an acute d ietary e xpo s ure assessment was only conducted for fe m a l es 1 3-49 years o ld
. The unrefined ac ute dietary exposure es timate at th e 95 111 perce ntile is < 1 % of th e aPAD for f e male s 1 3 -49 years o ld. Results of the Chronic Dietary (Food a n d Drinkin g Water) Exposu re Assess m e nt The unrefined chronic d i etary (foo d and drinking wate r) expos ure to halosulfuron-methyl is below I-IED 's level of concern ( < 100% of th e c PAD ) for th e genera l 

### U.S
. p op ul a tion and all population s ub gro up s . The ch ro nic di e tary expos ure es tim ates a r e 2. 1 % of the c P A D for the gen e ra l 

### U.S
. populat ion and 5.7 % of the cPAD fo r ch i ldren 1

- 2 year old , the mo s t highly e xp ose d populat ion subgroup. Tab le 4. Summary of D ietary (Food a nd Dr i nking Water) Exposure and R isk for H a los ul f u ro n -Met hy l. Ac ute D ietary Chron ic Dietary (9Sth Percenti le) Popu lation Subgro u p D ietary Dietary Exposure % aPAD* Ex po s u re % cPAD* (me/k.2/day) ( m g/kg/day) Ge ne ral U.S. Po pulation 0
.002091 2.1 All I nfants ( < I yea r o ld ) 0.004987 5 .0 C hil dre n 1-2 yea r s o ld * 0.005740 5.7 C hildre n 3

- 5 y ears old NIA N IA 0.004025 4.0 C hildren 6-12 ye ars old 0.002488 2.5 Yo uth 13

- 19 year s o l d 0.00 I 597 1.6 Adults 20 -4 9 yea rs o ld 0.0018 17 1.8 Adult s 50

-99 years o ld 0.001767 1.8 Femal es 13-4 9 y ear s old 0.004 139 < I 0.001812 1.8 * Th e s ubpopulat1011 (s) w11h the hi ghe s t nsk estim ate s . The highe st ri sk est im ate is bo lded. VIII. C haracterizat ion of Inputs/O u tput s The acu te and chronic assessments are con s idered to be unrefined and highly conservat ive. The residue levels u sed in the assessme nts fo r a ll co mm od iti es we r e th e es tablis hed o r reco mm ended tolerance leve l s. The assessments were conducte d u s in g the ass ump t io n that 10 0% of the crop was tre ated. Default (DEEM 7.8 1) processing factors were used unless processin g stud ies we re

Page 7of13Halosulfuron-Methyl Dietary Exposure and Risk Assessment DP Number: 0426724


### available (tomato and potato) and modeled esti m ated drinking water co nc ent rati o n s we re included in the assessments. These assessments could be refined , wh ich would likely s ignificant l y decrease the est im ated risk, with percent crop treated es tim ates , ant icipat ed residues, o r m o nitorin g data. Since ri sk est imates are well be low H E D 's leve l of concern, a m o re hi ghl y refined analysis is n ot ne eded at this time. 

### IX. Co nclus ion s Acute and chron ic dietary exposure assessments were conducted for the proposed uses on Pome Fruit Group 11

- 10 and F ruit , S ma ll Vine C li mbin g Subgroup I 

### 3-0 7F. The analyses were unrefined assessments . For both of the acute and c hroni c assessments, assessments for a ll populations of concern have risk es timate s that are be low HED 's level of concern. HED i s confident that the ac ute and chron ic assessments do not underestimate ri sk to th e genera l U.S. population or any population su b gro up. 

### X. Lis t o f A ttac hm e nts Acute and Chronic Residue Input file Acute Resu lts fil e • Chronic Re su lt s Fi le

Page 8 of 13H alosulfuron-Meth yl Dietary Exp osure and Ri s k Assessment DP Numbe r: D4 26724 

### Attac hm ent 1 : Acut e a nd C hronic Res idu e Inpu t Fil e Filename: C:\Users\KRURY\Document s \My Work Files\ Ha losulfuron\Pome fruit and Sma ll Vine Climbing\Dietary\ACUTE & CHRONIC 042415.R08 Chemical: halosulfuron-methyl RfD(Chronicl: .1 mg/kg bw/day NOEL(Chronic): 10 mg/kg bw/day RfD(Acutel: .s mg/kg bw /day NOEL( Acu te): SO mg/kg bw /day Date created/last modified: 04-24 -2 015/12:57:10 Program ver . 3.16, 03-08 -d Comment: Acute is only for Fema les 13 -49 yrs ; N e w Us es Artichoke a n d Caneberry s u group 13

- 07A Crop EPA Code Grp Commodity Name Def Res (ppm) 0103015000 lCD 0103015001 lCD 0103017000 lCD 0103082000 lC D 0103082001 lCD 0103139000 lCD 0103166000 lCD 0103166001 lCD 0103167000 lCD 0103296000 lC 0103297000 lC 0103297001 lC 0103298000 lC 0103298001 lC 0103299000 lC 0103299001 lC 0103300000 lC 0103300001 lC 0 10336600 0 lCD 0103366001 lCD 0103371000 lCD 0103387000 lCD 0 103406 000 lCD 0103407000 lCD 0402322000 4B 0600347000 6 0600349000 6 0600349001 6 0600350000 6 0600350001 6 0601043000 6A 0601043001 6A 0601257000 6A 0601349500 6AB 0602031000 6B 0602033000 6B 0602037000 6B 0602255000 6B 0602255001 6B 0602259000 6B 0603030000 6C 0603032000 6C 0603034000 6C 060 3035 000 6C 0603036000 6C 0603038000 6C 0603039000 6C 0603040000 6C 0603041000 6C 0603042000 6C 0603098000 6C 0603098001 6C Arrowroot, flour Arrowroot, flour-b abyfood Artichoke, Jerusalem Cassava Ca ss ava-baby food Dasheen, corm Ginger Ginger-babyfood Ginger, dried Po tat o, chips Potato, dry (gran ules / flakes) Potato, dry (gra nul es/ fl akes)-b Potato, flour Potato, flour-baby fo od Potato, tuber, w/peel Potato, tuber , w/peel-babyfood Potato, tuber, w/o peel Po ta to, tuber, w/o peel -babyfood Sweet potato Sweet potato-babyfood Ta nier, corm Turmeric Yam, true Yam bean Rhubarb Soybean, seed Soybean, soy milk So ybe a n, soy milk- baby food or in Soybean, oil Soybean, oil-babyfood Be an, snap, succ ulent Bean, snap, succul en t
- babyfood Pea, edible podded, succu lent Soybean, vegetable Bean, broad , succule nt Bean, cowpea , succu lent Bean, lima , succule nt Pea, succulent Pea, succulent- b abyfood Pea , pigeon, succulent Bean, black, seed Bean, Bean, Bean, Bean, Bean, broad, seed cowpea, seed

great northern, kidney, see d lim a , seed Bean, mung, seed Be a n, navy, seed Bean, pink, seed Bean, pinto, seed Chickpea, seed Chickpea, seed-ba byfood seed

Page 9of 13 0
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. 050000 0
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. 050000 0.050000 0
. 050000 0
. 050000 Adj
. Factors Ill 112 1.000 1.000 1.000 1.000 1. 000 1
. 000 1
. 000 1
. 000 1
. 000 1.000 1 .000 1 .000 1.000 1. 000 1. 000 1.000 1.000 1.000 1
. 000 1 .000 1
. 000 1. 000 1. 000 1. 000 1
. 000 1
. 000 1
. 000 1
. 000 1. 000 1
. 000 1
. 000 1
. 000 1
. 000 1
. 000 1
. 000 1.000 1 .000 1.000 1.000 1.000 1
. 000 1.000 1
. 000 1. 000 1. 000 1.000 1. 000 1
. 000 1
. 000 1.000 1. 000 1
. 000 1. 000 1.000 1
. 000 1. 000 1. 000 1. 000 1
. 000 1
. 000 1
. 000 1.000 1.000 1. 000 1. 000 1. 000 1
. 000 1
. 000 1. 000 1.000 1.000 1.000 1. 000 1. 000 1.000 1
. 000 1. 000 1
. 000 1.000 1
. 000 1.000 1. 000 1
. 000 1
. 000 1
. 000 1.000 1.000 1.000 1.000 1
. 000 1
. 000 1 .0 00 1.000 1.000 1
. 000 1.000 1. 000 1. 000 1.000 1.000 1. 000 1. 000 1. 000 1. 000 Comme nt
9E7577 9E7577 9 E7577 9 E7577 9 E7577 9E7577 9E7577 9E7577 9E7577 9E7 577 9E7577 9E7577 9E7577 9 E7577 9E7577 9E7577 9E7577 9E7577 9E7577 9E7577 9 E7577 9 E7577 9 E7577 9E7577 9E7577 8F7424
8F742 4

9E7577 9E7577 9E7577 9E7577 9E7577 9E7577Ha losulfuro n-Meth yl Dietary Ex po sure and Ri sk Assessmen t

0603099000 6C 06031B2000 6C 06031B2001 6C 060334BOOO 6C 060334B001 6C OS01374000 SA OS01375000 SA OB01375001 SA OB01376000 SA OB01376001 SA OS01377000 SA OS01377001 BA OS0137SOOO BA OS0137S001 SA OS01379000 SA OS013SOOOO SA 0802148000 SBC OB02234000 BBC OS02270000 BB 0802270001 BB OB02271000 SB OB02271001 BB OB02272000 SBC OS02272001 SBC OS02273000 SBC 0901075000 9A 09011B7000 9A 0901399000 9A 0901400000 9A 0902021000 9B 09020SSOOO 9B 0902102000 9B 0902135000 9B 090230SOOO 9B 0902309000 9B 0902356000 9B 0902356001 9B 0902357000 9B 0902357001 9B 1100007000 11 llOOOOSOOO 11 llOOOOBOOl 11 1100009000 11 1100009001 11 1100010000 11 1100010001 11 1100011000 11 1100011001 11 1100129000 11 1100173500 11 1100210000 11 1100266000 11 1100266001 11 1100267000 11 Chickpea, flour Guar, seed Guar, seed-babyfood Soybean, flour Soybean, flour-babyfood Tomatillo Tomato Tomato -b abyfood Tomato, past e Tomato, paste-babyfood Tomato, puree Tomato, puree-babyfood Tomato, dried Tomato, dried-babyfood Tomato, juice Tomato, Tree Eggplant Okra Pepper , bell Pepper, bell

- babyfood Pepper, bell, dried Pepper, bell, dried-babyfood Pepper , nonbell Pepper, nonbell-babyfood Pepper, nonbell, dri ed Cantaloupe Honeydew melon Watermelon Watermelon , juice Balsam pear Chayote, fruit Chinese waxgourd Cucumber Pumpki n Pumpkin, seed Squash, summer Squash, summer-babyfood Squash , winter Squash , winter-babyfood Apple, fruit with peel Apple, peeled fruit Apple, peeled fruit-babyfood Apple, dried Apple , dried -baby food Apple, juice Apple, juice-babyfood Apple, sauce Apple, sauce - babyfood Crabapple Goji berry Loquat Pear Pear-babyfood Pear , dried ll0026BOOO 11 Pear, juice 1100268001 11 Pear, juice-babyfood 1100310000 ll Quince 1301055000 13A Blackberry Full comme nt: OPll 0405659 1301056000 13A Blackberry, juice Full comme nt: OPll 0405659 1301056001 13A Blackberry, juice -babyfood Full comme nt: OPll 0405659 130105BOOO l3A Boysenberry Full comme n t : OPll 0405659 1301208000 13A Loganberry Full comment: DPll 0405659 0
. 050000 0.050000 0
. 050000 0
. 050000 0
. 050000 0
. 050000 0
. 050000 0
. 050000 0
. 050000 0
. 050000 0
. 050000 0
. 050000 0
. 050000 0
. 050000 0.050000 0
. 050000 0
. 050000 0
. 050000 0.050000 0.050000 0.050000 0.050000 0
. 050000 0
. 050000 0
. 050000 0.100000 0.100000 0
. 100000 0 .1 00000 0
. 500000 0 .5 00000 0 .5 00000 0
. 500000 0
. 500000 0
. 500000 0 .5 00000 0 .5 00000 0.500000 0
. 500000 0
. 050000 0
. 050000 0
. 050000 0.050000 0
. 050000 0
. 050000 0
. 050000 0
. 050000 0.050000 0
. 050000 0
. 050000 0
. 050000 0
. 050000 0
. 050000 0
. 050000 0
. 050000 0
. 050000 0.050000 0.050000 0.050000 0.050000 0
. 050000 0
. 050000
Page 10 o f 13 1.000 l. 000 1
. 000 l. 000 l. 000 1.000 1. 000 l. 000 l. 000 1.000 1.000 l. 000 14. 300 14. 300

l. 500 1.000 1.000 l. 000 1.000 1.000 1.000 1.000 l. 000 1.000 l. 000 1.000 1.000 1.000 1.000 1.000 l. 000 1.000 l. 000 l. 000 1.000 l. 000 1.000 l. 000 1.000 1.000 1.000 1
. 000 S.000 S.000 1.300 l. 300 1.000 1.000 1.000 1.000 1.000 1.000 1.000 6
. 250 l. 000 1.000 1.000 1.000 l. 000 1.000 l. 000 1.000 DP Number: D 426724

1.000 1.000 l. 000 1
. 000 1.000 1.000 1
. 000 1
. 000 l. 000 l. 000 1.000 1
. 000 1
. 000 1.000 1.0 00 1.000 1.000 l. 000 1.000 1.000 l. 000 1.000 1.000 1
. 000 l.000 1.000 1
. 000 1. 000 1. 000 1
. 000 1.000 1.000 1
. 000 l. 000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1. 000 1.000 1.000 1
. 000 1.000 1.000 1.000 1
. 000 1
. 000 1
. 000 1.000 1.000 1
. 000 1
. 000 1
. 000 1.000 1
. 000 1
. 000 1.000 1
. 000 l. 000 OF6169 OF6169 OF6169 OF6169 OF6169 OF6169
9£7577

OE6085 OE60B5 OE6085 OE6085 9E7577 9E7577 9E7577 9£7577 9£7577 9£7577 9£7577 9£7577 9E7577 4E8297 4EB297 4ES297 4ES297 4ES297 4ES297 4EB297 4ES297 4EB297 OPll 04 OPll 04 OPll 04 OPll 04 OPll 04H alosulfuron-Methyl Dietary Expo s ure and Ri sk Assessment

1301320000 13A Raspberry Full comment: OPU 0405659 1301321000 13A Raspberry, juice Full comment: OPU 0405659 1302057000 13B 1302057001 13B 1302136000 13B 1302137000 13B 1302149000 13B 130217400 0 13B 1302191000 13B 1304175000 130 1304176000 130 1304176001 130 1304179000 130 1400003000 14 1400003001 14 14 00004 000 14 1400004001 14 1400059000 14 1400068000 14 1400081000 14 1400092000 14 1400155000 14 1400156000 14 1400185000 14 1400213000 14 1400269000 14 1400282000 14 1400391000 14 1500120000 15 1500120001 15 1500121000 15 1500121001 15 1500122000 15 1500123000 15 1500123001 15 1500124000 15 1500124001 15 1500125000 15 1500125001 15 1500126000 15 1500 127000 15 1500127001 15 1500226000 15 1500323000 15 1500323001 15 1500324000 15 1500324001 15 1500325000 15 1500325001 15 1500326000 15 1500326001 15 1500344000 15 1500345000 15 1500405000 15 2003128000 20C 2003128001 20C 3100044000 31 3100044001 31 3100045000 31 3100046000 31 3100046001 31 3100047000 31 3100047001 31 3100048000 31 3100049000 31 Blueberry Blueberry-babyfood currant cu r rant, dried Elderberry Gooseberry Huckleber ry Grape Grape, juice Grape, juice-babyfood Grape, wine and sherry Almond Almond -babyfood Almo n d, oil Almond , oil-babyfood Brazil nut Butternut Cashew Chestnut Hazelnut Hazelnut, oil Hickory nut Macadamia nut Pecan Pistachio Walnut Corn, field, flour Corn, field, fl our- baby food Corn, field, meal Corn, field, meal-babyfood Corn, field, bran Corn, field, starc h Corn, field , starch-babyfood Corn, field, syrup Corn, field, syrup-babyfood Corn, field, oil Corn, field, oil-baby f ood Corn, pop Corn, sweet Corn, sweet-babyfood Millet, grain Rice, white Rice, white-babyfood Rice, brown Rice, brown-babyfood Rice, flour Rice, flour -babyfood Rice , bran R

ic e , bran-babyfood Sorghum, grain Sorghum, syrup Wild rice Cottonseed, oil Cottonseed, oil-babyfood Beef, meat Beef, meat -babyfood Beef, meat, dr ied Beef , meat byproduc t s Bee f , meat byproducts-babyfood Beef, fat Beef, fat-babyfood Beef, kidney Beef, liver 0
. 050000 0.050000 0.050000 0
. 050000 0.050000 0
. 050000 0
. 050000 0
. 050000 0
. 050000 0.050000 0
. 050000 0.050000 0.050000 0.050000 0.050000 0
. 050000 0
. 050000 0
. 050000 0.050000 0
. 050000 0.050000 0
. 050000 0
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. 050000 0.050000 0.050000 0.050000 0.050000 0
. 050000 0
. 050000 0.050000 0.050000 0
. 050000 0
. 050000 0.050000 0
. 050000 0
. 050000 0.050000 0
. 050000 0
. 050000 0
. 050000 0
. 010000 0.050000 0
. 050000 0
. 050000 0.050000 0
. 050000 0.050000 0
. 050000 0.050000 0.050000 0
. 050000 0
. 050000 0
. 050000 0.050000 0.050000 0
. 050000 0
. 050000 1
. 000000 1
. 000000 0
. 050000 0
. 050000 1
. 000000 1.000000

Page 11 of 13 DP Numb er : D4 26724

1.000 1.000 OP# 04 1.000 1
. 000 OPU 04 1.000 1
. 000 1
. 000 1
. 000 1
. 000 1 .00 0 1.000 1.000 1.200 1.200 1.000 1.000 1.000 1
. 000 1
. 000 1. 000 1
. 000 1.000 1.000 1
. 000 1.000 1
. 000 1. 000 1.000 1
. 000 1.000 1.000 1
. 000 1
. 000 1.000 1.000 1.000 1.000 1.000 1.000 1
. 000 1.000 1.000 1.000 1.000 1.000 1.000 1.0 00 1.000 1.000 1.000 9E7577 9E7577 9£7577 9E7577 9E757 7 9E7577 9E7577 4E8297 4E8297 4E8297 4E8297 8F4937 8 F4937 8F4937 8F4937 8F4937 8F4937
8 F4937 1
. 000 1.000 8F4937 1.000 1
. 000 8F4937 1.000 1
. 000 8F4937 1.000 1.000 6F4661 1.000 1.000 1
. 000 1.000 6F4661 1. 000 1. 000 1.000 1.000 6F4661 1
. 000 1. 000 6F4661 1.000 1.000 1.500 1.000 6F4661 1.500 1.000 1.000 1.000 6F4661 1.000 1.000 1
. 000 1. 000 1 .000 1
. 000 1.000 1.000 1.000 1
. 000 1
. 000 1
. 000 1 .0 00 1.000 1.000 1.000 1.000 1.000 1
. 000 1. 000 1
. 000 1
. 900 1
. 000 1
. 000 1.000 1.000 1
. 000 1. 000 1.000 1. 000 1. 000 1.000 1. 000 1.000 1.000 1.000 1. 000 1.000 1.000 1. 000 1. 000 1
. 000 1.000 1.000 1.0 00 1.0 00 1. 000 1. 000 1.000 1. 000 1
. 000 1.000 1. 000 1. 000 6F4661 6 F4661
8F4937 8F4937 8F4937 8F4937

8F4937 8F4937H a losulfu ro n-M e th yl Di eta ry Ex pos ure and Ri sk Assess m e nt DP Numb er : 0426724

3100049001 31 Beef, liver-babyfood l.000000 l.000 l
. 000 3200169000 32 Goat, meat 0
. 050000 1.000 1
. 000 3200170000 32 Goat, meat byproducts 1
. 000000 1
. 000 1
. 000 3200171000 32 Goat, fat 0.050000 1.000 1.000 3200172000 32 Goat, kidney 1.000000 1.000 1.000 3200173000 32 Goat, liver 1.000000 1
. 000 1
. 000 3300189000 33 Horse, meat 0.050000 1.000 1.000 3400292000 34 Pork, meat byproducts 0.100000 1.000 1.000 3F4193 3400 292001 34 Pork, meat byproducts-babyfood 0
. 1000 00 1.000 1
. 000 3400294000 34 Pork, kidney 0
. 100000 1
. 000 1. 000 3F4193 3400295000 34 Pork, liver 0
. 100000 1.000 1.000 3F4193 3500339000 35 Sheep, meat 0.050000 1.000 1.000 3500339001 35 Sheep, meat -ba byfood 0
. 050000 1.000 1. 000 3500340000 35 Sheep, meat byproducts 1. 000000 1
. 000 1
. 000 3500341000 35 Sheep, fat 0
. 050000 1. 000 1
. 000 3500341001 35 Sheep, fat-babyfood 0
. 050000 1.000 1.000 3500342000 35 Sheep, kidney 1
. 000000 1.000 1.000 35003 43000 35 Sheep, liv er 1
. 000000 1.000 1
. 000 3600222000 36 Milk, fat 0
. 050000 1
. 000 1
. 000 3600222001 36 Milk, fat-baby food/infant formu 0.050000 1. 000 1.000 3600223000 36 Milk, nonfat solids 0
. 050000 1.000 1.000 3600223001 36 M ilk, nonfat solids-baby food/in 0.050000 1.000 1.000 3600224000 36 Milk , water 0.050000 1.000 1
. 000 3600224001 36 Milk , water
- babyfood/infant form 0
. 050000 1. 000 1. 000 3600225001 36 Milk, sugar (lactose)

- baby food/ 0.050000 1. 000 1.000 8601000000 86A Water, direct, all sources 0
. 059200 1.000 1
. 000 DP#l358 Full comment: DPll358032 8602000000 868 Wat er , indirect, all sources 0
. 059200 1.000 1. 000 9500016000 0 Artichoke, globe 0
. 050000 1. 000 1
. 000 9500019000 0 Asparagus 0.800000 1. 000 1. 000 1F6229 9500177000 0 Grape, leaves 0
. 050000 1.000 1.000 4E8297 9500178000 0 Grape, rais i n 0
. 050000 4.300 1
. 000 4E8297 9500362000 0 Sugarcane, sugar 0
. 050000 1. 000 1.000 6F4661 9500362001 0 Sugarcane, sugar-baby food 0
. 050000 1
. 000 1.000 9500363000 0 Sugarcane, molasses 0.050000 1. 000 1.000 6F4661 9500363001 0 sugarcane, molas ses-babyfood 0.050000 1. 000 1.000

P

age 1 2of 13Halo s u l furon-Mcthy l Dietary Ex p os ure a nd Ri sk Asse ss men t D P N um b e r : D 426724


### A tt ac hm e nt 2 : Ac ute R e s ults U.S. EPA DEEM-FCID ACUTE Analysis for HALOSULFURON-METHYL Residue file: ACUTE & CHRONIC 042415.R08 Ver. 3.16, 03-08-d NHANES 2003-2008 2-Day Adjustment factor tt2 NOT used
. file dated: 04-24-2015/12 :57:10 Analysis Date: 04-24-2015/13 :04:11 Residue NOEL (Acute) 

### = 50.000000 mg/kg body-wt/day RAC/FF intake summed over 24 hours Run Comment: "Acute is only for Females 13-49 yrs; New Uses Artichoke and Cane berry sugroup 13-07A"**======================= ================================** **=~:=•================== =**  Summary calculations--per capita: 9Sth Percentile---- 99th Perce nt ile---- ---99
. 9th Percentile---- Exposure % aRfD MOE Expos ur e % aRf D MOE Exposure % aRfD MOE Female 13-49 : 0.004139 0.83 12079 0
. 0058 18 1.16 8594 0.008261 1. 6S 6052 

### A ttac hm e n t 3 : C hro ni c Re s ults
U.S
. EPA Ver. 3.16, 03-08-d DEEM-FCID Chronic analysis for HALOSULFURON-METHYL Residue file name: C:\Users\KRURY\Documents\My Work Vine Climbing\Dietary\ACUTE & CHRONIC 04241S.R08 NHANES 2003

- 2008 2-day Files\Halosulfuron\Pome fruit and Small Adjustment factor ff2 NOT used. Analysis Date 04-24-201S/l2 :S7:44 Residue file dated: 04-24-201S/12 :57:10 Reference dose (RfD, Chronic) 

### = .l mg/kg bw/day COMMENT 1: Acute is only for Females 13-49 yrs; New Uses Artichoke and Caneberry sugroup 13-07A**=============2============================================n==~•==z=============**

Population

Subgroup Total US Population Hispanic Non-Hisp-White Non-Hisp-Black Non-Hisp-Other Nursing Infants Non-Nursing Infants Female 13+ PREG Children l-6 Children 7-12 Male 13-19 Female 13-19/NP Male 20+ Female 20+/NP Seniors SS+ All Infants Female 13-SO Children 1-2 Children 3-S Children 6-12 Youth 13-19 Adults 20-49 Adulcs S0-99 Female 13-49 Total exposure by population subgroup
Tocal Exposure mg/kg b ody w t/day 0 .0 0209 1 0 .0 02190 0.002108 0.001774 0.002361 0.002106 0
. 006273 0.001907 0.004527 0.002330 0.001609 0.001585 0.00172S 0
. 001856 0
. 001750 0
. 004987 0.001810 O.OOS740 0
. 004025 0
. 002488 0
. 001597 0.001817 0.001767 0
. 001812

P

age 13of 13 Percent of Rfd2 .1% 2
. 2% 2 .1% 1. 8% 2 .4% 2 .1% 6 .3% 1.9% 4
. 5\ 2
. 3% 1.6% 1
. 6% 1
. 7\ l.9% l.8% S.O\ 1. 8% 5.7% 4.0% 2.5% 1.6 % 1. 8% 1. 8% 1. 8%