UNI T ED STATES ENVIRONMENTAL PROTECTION AGENCY W AS HIN GTO N, D . C. 20460 OFFICE OF CHE MI CAL SAFETY A ND POLLUTIO N PREVENTION



### MEMORANDUM Date: January 31, 2013 

### SUBJECT: Ametryn: Review of Hu man I nc ide nts PC Co d e: 080801 Decision No.: 473109 Petition No.: NA Risk Assessment Ty p e: NA TXRNo.: NA MR ID No.: NA DP Barc ode : 04076.'1? Reg i st r atio n No. : NA Regu latory Action : NA Case No.: NA CAS No.: 834

- 12-8 40 CFR: NA 

### FROM : S h anna Reco re, In dustri al Hygienist Toxico logy a nd Epid emi o logy Branch Heal th Effect Division (7509 P ) and Elizabeth Evans, Environmental Protection Specialist Toxicology and Epidemiology Branch

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# - Health Effect Division (750 9P ) 

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### THROUGH: David J. Miller, Acting B ranch Chief · ·

# '.fi/**J/ ~~$£1**  T oxico l ogy an d Epi d emiology Branch Hea lth Effects Di visi on (7 5 0 9P) 

### TO: Kelly Lowe, Risk Ass e ssor Risk Assessment Branch I H ealth Effects Division (7509P) and Molly Clayton, Chemical Review Manager Risk Management & Imp lementation Branch 3 Pesticide Re-evaluati on D iv i s i on (7508P) Summarv and Co n clusions Ver.Apr.08

No incidents were identified for ametryn in either IDS or N IOSH SENSOR-Pesticides. There does not appear to be a concern at this time that would warrant further investigat i on. The Agency will continue to monitor the incident informat ion and if a concern is triggered, addit ional analysis will be included in the risk assessment.
Page 1 of 4The Agricultural Health Study (AHS) is also a potential source of information associated with human health effects associated with certain pesticides. Ametryn is not included in the AHS, and therefore this study does not provide informa t ion for this report.
Detailed Review 

### I. ACTION REQUESTED This review is intended to fulfill our requirement to docket summaries of incident data that were reported to the Agency , as well as to ensure human incident data and the Agricu ltu r al Health Study (AHS) are part of the problem formulation phase of registration review. Reports of adverse health effects a llegedly due to a specific pesticide exposure 

### (i.e., an "incident") are largely self -repo rted and therefore, generally speaking, neither exposure to a pesticide or reported symptom (or the connection between the two) is validated or otherwise confirmed. Typically, causation cannot be determined based on incident data. However, incident information can be an important source of feedback to the Agency: incidents of severe outcome, or a suggested pattern or trend among less severe incidents, can signal the Agency to further investigate a particular chemical or product. Observational ep idemi ology studies re l ate the risk of disease, 

### e.g. , cancer, and exposure to an agent such as a pesticide product in the general population or specific sub-groups like pes ticide applicators. 

### II. BACKGROUND Ametryn is an herbicide used to control broadleaf and grass weeds in fields planted with field corn, popcorn, pineapple , and sugarcane. For this evaluation, bo th OPP Incident Data System (IDS) and the Centers fo r Disease Control and Prevention/National Institute for Occupational Safety and Health (CDC/NIOSH) Sentinel Event Notification System for Occupational Risk-Pesticides (SENSOR) databases were consulted for pesticide incident data on the acti ve ingredient ametryn (PC Code: 080801 ). The purpose of the database search is to identi fy potential patterns in the frequency and severity of the health effects attributed to ametryn exposure. In addition, findings from the AHS were reviewed
. The Agricultural Health Study (AHS) is a high quality, prospective epidemiology stud y evaluating the link between pesticide use and vario u s health outcomes including cancer. Ametryn i s not included in the AHS, and therefore this study does not provide information for this report.


### III. RESULTS/DISCUSSION a. IDS (Incident Data System) OPP's IDS includes reports of alleged human health incidents from various sources, including mandatory Federal Insectic ide, Fungicide and Rodenticide Act (FIFRA) Section 6(a)(2) reports from registrants, other federal and state health and environmental agencies, and individual consumers. Since 1992, OPP has compiled these reports in IDS. IDS contai ns reports from Page 2 of4