The following material represents the individual male reproductive data from the journal article

(obtained via email communication with Dr. Julie Boberg):

Boberg, J; Christiansen, S; Axelstad, M; et al. (2010) Reproductive and behavioral effects of 

diisononyl phthalate (DINP) in perinatally exposed rats. Reproductive Toxicology. 2011 Feb; 

31(2):200-9. Epub 2010 Nov 12 [HERO ID 806135]
Birth and lactation data - Individual data from Boberg et al 2010 study (HERO ID 806135)

Group 1 = control; group 2 = DINP-300; group 3 = DINP-600; group 4 = DINP-750; group 5 = DINP-900

Dams dosed by gavage

page 1 of 19

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Litter Block Group Pup 

Number Sex Birth weight male AG male Birth weight female AG female Nipples male Nipples female AGI male AGI female

4 11 1 1 1 5.70 25.00 3.00 13.99528425

4 11 1 2 1 5.90 23.00 2.00 12.7284982

4 11 1 3 1 5.80 20.00 3.00 11.13150787

4 11 1 4 1 5.90 22.00 3.00 12.17508523

4 11 1 5 1 5.90 19.00 4.00 10.51484634

4 11 1 6 1 5.90 24.00 3.00 13.28191116

4 11 1 7 1 6.30 18.00 1.00 9.74598313

4 11 1 8 1 5.20 20.00 0.00 11.54415673

4 11 1 9 2 5.00 10.00 12.00 5.848035476

4 11 1 10 2 5.50 13.00 13.00 7.364712354

4 11 1 11 2 5.40 12.00 12.00 6.839903787

4 11 1 12 2 5.90 12.00 12.00 6.640955582

4 11 1 13 2 6.10 12.00 12.00 6.567568851

4 11 1 14 2 5.50 11.00 12.00 6.231679684

4 11 1 15 2 5.70 13.00 12.00 7.277547808

4 11 1 16 2 5.00 10.00 5.848035476

7 11 2 1 1 6.90 26.00 0.00 13.65705267

7 11 2 2 1 6.80 25.00 2.00 13.1958399

7 11 2 3 1 5.70 23.00 2.00 12.87566151

7 11 2 4 1 6.20 23.00 1.00 12.51979659

7 11 2 5 2 6.20 12.00 12.00 6.532067785

7 11 2 6 2 5.70 12.00 12.00 6.717736438

7 11 2 7 2 4.70 12.00 12.00 7.163885348

7 11 2 8 2 5.90 13.00 12.00 7.194368548

7 11 2 9 2 6.60 14.00 13.00 7.46357195

8 11 2 1 1 6.00 24.00 1.00 13.207709

8 11 2 2 1 7.10 24.00 1.00 12.48700998

8 11 2 3 1 6.40 20.00 1.00 10.77217345

8 11 2 4 1 6.10 22.00 1.00 12.04054289

8 11 2 5 1 6.70 22.00 1.00 11.66982688

8 11 2 6 1 6.20 21.00 2.00 11.43111862

8 11 2 7 2 6.20 12.00 13.00 6.532067785

8 11 2 8 2 6.10 12.00 12.00 6.567568851

8 11 2 9 2 6.80 13.00 12.00 6.861836748

8 11 2 10 2 5.80 12.00 12.00 6.678904724

11 11 3 1 1 6.40 22.00 4.00 11.8493908

11 11 3 2 1 5.90 22.00 4.00 12.17508523
Birth and lactation data - Individual data from Boberg et al 2010 study (HERO ID 806135)

Group 1 = control; group 2 = DINP-300; group 3 = DINP-600; group 4 = DINP-750; group 5 = DINP-900

Dams dosed by gavage

page 2 of 19

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A B C D E F G H I J K L M

Litter Block Group Pup 

Number Sex Birth weight male AG male Birth weight female AG female Nipples male Nipples female AGI male AGI female

11 11 3 3 1 4.90 21.00 3.00 12.3638559

11 11 3 4 1 5.20 20.00 4.00 11.54415673

11 11 3 5 1 5.80 22.00 4.00 12.24465866

11 11 3 6 1 5.70 23.00 6.00 12.87566151

11 11 3 7 1 5.90 22.00 1.00 12.17508523

11 11 3 8 1 4.60 21.00 1.00 12.62699526

11 11 3 9 1 6.30 22.00 11.91175716

11 11 3 10 2 5.50 11.00 12.00 6.231679684

12 11 3 1 1 5.90 22.00 1.00 12.17508523

12 11 3 2 1 5.10 23.00 2.00 13.36198902

12 11 3 3 1 5.60 22.00 4.00 12.38872668

12 11 3 4 1 5.70 21.00 2.00 11.75603877

12 11 3 5 2 5.40 11.50 12.00 6.554907796

12 11 3 6 2 5.00 12.00 12.00 7.017642572

12 11 3 7 2 5.60 12.00 12.00 6.757487283

12 11 3 8 2 6.20 12.00 12.00 6.532067785

12 11 3 9 2 5.90 12.00 12.00 6.640955582

12 11 3 10 2 5.00 13.00 12.00 7.602446119

12 11 3 11 2 5.90 12.00 12.00 6.640955582

16 11 4 1 1 6.70 22.00 4.00 11.66982688

16 11 4 2 1 6.10 20.00 7.00 10.94594808

16 11 4 3 1 5.70 21.00 5.00 11.75603877

16 11 4 4 1 5.90 21.00 3.00 11.62167227

16 11 4 5 1 5.80 20.00 4.00 11.13150787

16 11 4 6 1 6.50 21.00 3.00 11.25247809

16 11 4 7 2 5.60 11.00 12.00 6.194363342

16 11 4 8 2 5.90 10.00 12.00 5.534129652

16 11 4 9 2 6.00 12.00 12.00 6.603854498

16 11 4 10 2 5.90 10.00 12.00 5.534129652

16 11 4 11 2 5.50 11.00 12.00 6.231679684

16 11 4 12 2 5.80 11.00 12.00 6.12232933

19 11 5 1 1 6.30 20.00 4.00 10.82887014

19 11 5 2 1 6.40 21.00 4.00 11.31078212

19 11 5 3 2 6.00 11.00 12.00 6.05353329

19 11 5 4 2 6.50 11.00 12.00 5.894155188

19 11 5 5 2 5.30 11.00 13.00 6.309099771

19 11 5 6 2 6.40 11.00 12.00 5.924695398

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Birth and lactation data - Individual data from Boberg et al 2010 study (HERO ID 806135)

Group 1 = control; group 2 = DINP-300; group 3 = DINP-600; group 4 = DINP-750; group 5 = DINP-900

Dams dosed by gavage

page 3 of 19

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A B C D E F G H I J K L M

Litter Block Group Pup 

Number Sex Birth weight male AG male Birth weight female AG female Nipples male Nipples female AGI male AGI female

19 11 5 7 2 6.00 10.00 13.00 5.503212081

20 11 5 1 1 5.20 22.00 4.00 12.69857241

20 11 5 2 2 5.60 12.00 12.00 6.757487283

20 11 5 3 2 5.30 11.00 12.00 6.309099771

20 11 5 4 2 5.40 12.00 12.00 6.839903787

21 12 1 1 1 6.30 26.00 5.00 14.07753119

21 12 1 2 1 6.60 26.00 4.00 13.86091934

21 12 1 3 1 6.20 25.00 2.00 13.60847455

21 12 1 4 1 6.30 26.00 2.00 14.07753119

21 12 1 5 1 6.30 21.00 4.00 11.37031365

21 12 1 6 1 6.20 23.00 3.00 12.51979659

21 12 1 7 2 6.20 13.00 12.00 7.076406767

21 12 1 8 2 6.30 14.00 12.00 7.580209101

21 12 1 9 2 6.00 12.00 13.00 6.603854498

21 12 1 10 2 6.10 13.00 13.00 7.114866255

21 12 1 11 2 6.40 13.00 12.00 7.001912743

21 12 1 12 2 6.00 10.00 12.00 5.503212081

21 12 1 13 2 6.00 10.00 13.00 5.503212081

24 12 1 1 1 5.90 24.00 1.00 13.28191116

24 12 1 2 1 6.50 23.00 1.00 12.32414267

24 12 1 3 1 6.20 25.00 0.00 13.60847455

24 12 1 4 1 6.50 23.00 1.00 12.32414267

24 12 1 5 1 6.30 22.00 1.00 11.91175716

24 12 1 6 1 6.10 13.00 12.00 7.114866255

24 12 1 7 2 6.00 13.00 12.00 7.154175706

24 12 1 8 2 5.70 12.00 13.00 6.717736438

24 12 1 9 2 6.20 13.00 12.00 7.076406767

24 12 1 10 2 6.20 11.00 12.00 5.987728803

24 12 1 11 2 5.90 12.00 12.00 6.640955582

24 12 1 12 2 5.60 12.00 12.00 6.757487283

24 12 1 13 2 6.20 12.00 12.00 6.532067785

25 12 2 1 2 5.40 11.00 12.00 6.269911804

25 12 2 2 2 5.60 11.00 12.00 6.194363342

25 12 2 3 2 6.10 12.00 13.00 6.567568851

25 12 2 4 2 6.40 12.00 6.46330407

25 12 2 5 dead

26 12 2 1 1 6.50 20.00 2.00 10.7166458

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Birth and lactation data - Individual data from Boberg et al 2010 study (HERO ID 806135)

Group 1 = control; group 2 = DINP-300; group 3 = DINP-600; group 4 = DINP-750; group 5 = DINP-900

Dams dosed by gavage

page 4 of 19

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Litter Block Group Pup 

Number Sex Birth weight male AG male Birth weight female AG female Nipples male Nipples female AGI male AGI female

26 12 2 2 1 6.20 22.00 3.00 11.97545761

26 12 2 3 2 5.10 11.00 13.00 6.390516489

26 12 2 4 2 5.90 12.00 12.00 6.640955582

26 12 2 5 2 6.10 13.00 13.00 7.114866255

26 12 2 6 2 5.70 12.00 12.00 6.717736438

26 12 2 7 2 5.60 13.00 13.00 7.320611223

28 12 2 1 1 6.60 22.00 3.00 11.72847021

28 12 2 2 1 6.20 22.00 3.00 11.97545761

28 12 2 3 1 6.40 19.00 3.00 10.23356478

28 12 2 4 2 6.00 10.00 12.00 5.503212081

28 12 2 5 2 5.90 10.00 13.00 5.534129652

28 12 2 6 2 5.70 12.00 12.00 6.717736438

28 12 2 7 2 5.70 11.00 12.00 6.157925068

28 12 2 8 2 5.20 11.00 12.00 6.349286203

28 12 2 9 2 6.00 11.00 13.00 6.05353329

28 12 2 10 2 6.40 10.00 12.00 5.386086725

28 12 2 11 2 5.60 10.00 12.00 5.631239402

29 12 3 1 1 6.00 19.00 2.00 10.45610295

29 12 3 2 1 4.60 19.00 1.00 11.42442428

29 12 3 3 1 6.20 19.00 3.00 10.34244066

29 12 3 4 1 6.30 20.00 1.00 10.82887014

29 12 3 5 1 6.30 20.00 2.00 10.82887014

29 12 3 6 1 5.60 18.00 0.00 10.13623092

29 12 3 7 1 6.40 19.00 2.00 10.23356478

29 12 3 8 1 6.40 20.00 10.77217345

29 12 3 9 1 6.60 19.00 10.12913336

29 12 3 10 2 6.10 11.00 12.00 6.020271446

29 12 3 11 2 5.90 10.00 12.00 5.534129652

29 12 3 12 2 6.00 10.00 13.00 5.503212081

29 12 3 13 2 6.10 11.00 13.00 6.020271446

30 12 3 1 1 6.50 25.00 2.00 13.39580725

30 12 3 2 1 6.90 21.00 4.00 11.03069639

30 12 3 3 1 6.60 25.00 2.00 13.32780705

30 12 3 4 1 7.00 22.00 4.00 11.50067509

30 12 3 5 1 6.40 24.00 3.00 12.92660814

30 12 3 6 1 5.60 24.00 2.00 13.51497457

30 12 3 7 1 6.60 24.00 3.00 12.79469477

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Birth and lactation data - Individual data from Boberg et al 2010 study (HERO ID 806135)

Group 1 = control; group 2 = DINP-300; group 3 = DINP-600; group 4 = DINP-750; group 5 = DINP-900

Dams dosed by gavage

page 5 of 19

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A B C D E F G H I J K L M

Litter Block Group Pup 

Number Sex Birth weight male AG male Birth weight female AG female Nipples male Nipples female AGI male AGI female

30 12 3 8 2 6.50 13.00 12.00 6.965819768

31 12 3 1 1 6.40 22.50 4.00 12.11869513

31 12 3 2 1 6.40 21.00 1.00 11.31078212

31 12 3 3 1 4.90 18.00 3.00 10.59759077

31 12 3 4 1 6.30 24.00 3.00 12.99464417

31 12 3 5 1 6.60 20.00 1.00 10.66224564

31 12 3 6 2 6.10 13.00 12.00 7.114866255

31 12 3 7 2 6.00 11.00 12.00 6.05353329

31 12 3 8 2 5.80 12.00 13.00 6.678904724

31 12 3 9 2 5.30 11.00 12.00 6.309099771

31 12 3 10 2 6.30 10.00 13.00 5.414435072

31 12 3 11 2 6.10 10.00 12.00 5.472974042

32 12 3 1 1 5.90 21.00 4.00 11.62167227

32 12 3 2 1 6.30 24.00 4.00 12.99464417

32 12 3 3 1 6.00 23.00 2.00 12.65738779

32 12 3 4 1 6.50 22.00 4.00 11.78831038

32 12 3 5 1 5.90 22.00 3.00 12.17508523

32 12 3 6 1 6.30 25.00 2.00 13.53608768

32 12 3 7 2 6.40 14.00 13.00 7.540521415

32 12 3 8 2 6.40 14.00 12.00 7.540521415

33 12 4 1 1 5.60 20.00 3.00 11.2624788

33 12 4 2 1 6.00 22.00 4.00 12.10706658

33 12 4 3 1 4.90 20.00 4.00 11.77510086

33 12 4 4 1 5.80 18.00 4.00 10.01835709

33 12 4 5 1 5.80 23.00 5.00 12.80123405

33 12 4 6 1 5.40 20.00 3.00 11.39983964

33 12 4 7 2 5.80 10.00 12.00 5.565753937

33 12 4 8 2 5.60 12.00 13.00 6.757487283

33 12 4 9 2 5.60 10.00 12.00 5.631239402

33 12 4 10 2 5.60 13.00 12.00 7.320611223

33 12 4 11 2 5.70 10.00 13.00 5.598113698

33 12 4 12 2 5.00 10.00 12.00 5.848035476

33 12 4 13 2 5.80 10.00 12.00 5.565753937

35 12 4 1 1 6.10 23.00 1.00 12.5878403

35 12 4 2 1 6.40 22.00 1.00 11.8493908

35 12 4 3 1 6.50 22.00 1.00 11.78831038

35 12 4 4 2 6.20 13.00 12.00 7.076406767

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Birth and lactation data - Individual data from Boberg et al 2010 study (HERO ID 806135)

Group 1 = control; group 2 = DINP-300; group 3 = DINP-600; group 4 = DINP-750; group 5 = DINP-900

Dams dosed by gavage

page 6 of 19

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A B C D E F G H I J K L M

Litter Block Group Pup 

Number Sex Birth weight male AG male Birth weight female AG female Nipples male Nipples female AGI male AGI female

35 12 4 5 2 6.00 12.00 12.00 6.603854498

35 12 4 6 2 6.30 14.00 13.00 7.580209101

36 12 4 1 1 6.70 24.00 3.00 12.73072023

36 12 4 2 1 6.30 23.00 1.00 12.45320067

36 12 4 3 2 6.40 13.00 13.00 7.001912743

36 12 4 4 2 6.30 12.00 12.00 6.497322087

36 12 4 5 2 6.40 12.00 12.00 6.46330407

36 12 4 6 2 6.40 12.00 13.00 6.46330407

36 12 4 7 2 5.10 12.00 12.00 6.971472534

36 12 4 8 1

36 12 4 9 2

37 12 5 1 1 6.00 23.00 3.00 12.65738779

37 12 5 2 1 6.30 20.00 3.00 10.82887014

37 12 5 3 1 5.70 22.00 4.00 12.31585014

37 12 5 4 5.10 13.00 12.00 7.552428578

37 12 5 5 5.10 12.00 12.00 6.971472534

37 12 5 6 6.00 12.00 12.00 6.603854498

37 12 5 7 5.30 10.00 13.00 5.735545246

37 12 5 8 6.30 12.00 13.00 6.497322087

37 12 5 9 5.90 13.00 12.00 7.194368548

37 12 5 10 5.10 11.00 12.00 6.390516489

37 12 5 11 5.90 12.00 13.00 6.640955582

37 12 5 12 6.10 13.00 12.00 7.114866255

37 12 5 13 5.00 11.00 13.00 6.432839024

37 12 5 14 6.20 13.00 12.00 7.076406767

37 12 5 15 4.80 10.00 12.00 5.928155507

38 12 5 1 1 5.60 17.00 2.00 9.573106984

38 12 5 2 1 5.20 18.00 3.00 10.38974106

38 12 5 3 1 5.40 18.00 2.00 10.25985568

38 12 5 4 1 4.90 16.00 2.00 9.420080685

38 12 5 5 1 6.20 18.00 1.00 9.798101678

38 12 5 6 1 6.00 19.00 2.00 10.45610295

38 12 5 7 1 5.10 15.00 8.714340667

38 12 5 8 1 6.00 17.00 9.355460539

38 12 5 9 2 5.80 10.00 12.00 5.565753937

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Birth and lactation data - Individual data from Boberg et al 2010 study (HERO ID 806135)

Group 1 = control; group 2 = DINP-300; group 3 = DINP-600; group 4 = DINP-750; group 5 = DINP-900

Dams dosed by gavage

page 7 of 19

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A B C D E F G H I J K L M

Litter Block Group Pup 

Number Sex Birth weight male AG male Birth weight female AG female Nipples male Nipples female AGI male AGI female

39 12 5 1 1 6.50 21.00 2.00 11.25247809

39 12 5 2 1 6.50 20.00 2.00 10.7166458

39 12 5 3 2 6.10 10.00 12.00 5.472974042

39 12 5 4 2 5.70 10.00 12.00 5.598113698

39 12 5 5 2 5.90 11.00 12.00 6.087542617

39 12 5 6 2 5.40 11.00 12.00 6.269911804

39 12 5 7 2 6.20 11.00 13.00 5.987728803

39 12 5 8 2 5.80 11.00 13.00 6.12232933

39 12 5 9 2 6.00 10.00 12.00 5.503212081

40 12 5 1 1 5.60 19.00 2.00 10.69935486

40 12 5 2 1 5.20 20.00 4.00 11.54415673

40 12 5 3 1 6.10 21.00 2.00 11.49324549

40 12 5 4 1 5.60 19.00 3.00 10.69935486

40 12 5 5 1 5.30 20.00 3.00 11.47109049

40 12 5 6 1 6.00 19.00 4.00 10.45610295

40 12 5 7 2 5.90 10.00 13.00 5.534129652

40 12 5 8 2 5.40 10.00 13.00 5.699919822

40 12 5 9 2 6.00 10.00 12.00 5.503212081

40 12 5 10 2 5.60 10.00 12.00 5.631239402

40 12 5 11 2 5.70 10.00 12.00 5.598113698

40 12 5 12 1 dead

43 21 1 1 2 6.00 9.00 12.00 4.952890873

43 21 1 2 2 5.70 10.00 12.00 5.598113698

43 21 1 3 2 4.90 9.00 12.00 5.298795385

43 21 1 4 2 6.10 10.00 13.00 5.472974042

43 21 1 5 2 6.30 11.00 12.00 5.955878579

43 21 1 6 2 6.20 10.00 12.00 5.443389821

43 21 1 7 2 5.90 10.00 12.00 5.534129652

47 21 2 1 1 6.40 23.00 2.00 12.38799947

47 21 2 2 1 6.20 21.00 3.00 11.43111862

47 21 2 3 1 5.30 21.00 2.00 12.04464502

47 21 2 4 1 6.30 21.00 2.00 11.37031365

47 21 2 5 1 6.40 21.00 2.00 11.31078212

47 21 2 6 1 5.40 21.00 3.00 11.96983163

47 21 2 7 1 6.40 20.00 3.00 10.77217345

47 21 2 8 2 6.00 11.00 12.00 6.05353329

47 21 2 9 2 5.80 11.00 13.00 6.12232933

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Birth and lactation data - Individual data from Boberg et al 2010 study (HERO ID 806135)

Group 1 = control; group 2 = DINP-300; group 3 = DINP-600; group 4 = DINP-750; group 5 = DINP-900

Dams dosed by gavage

page 8 of 19

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Litter Block Group Pup 

Number Sex Birth weight male AG male Birth weight female AG female Nipples male Nipples female AGI male AGI female

47 21 2 10 2 6.50 10.00 12.00 5.358322898

47 21 2 11 2 5.90 11.00 12.00 6.087542617

47 21 2 12 2 6.20 12.00 12.00 6.532067785

48 21 2 1 1 6.30 21.00 1.00 11.37031365

48 21 2 2 1 6.30 16.00 2.00 8.663096115

48 21 2 3 1 6.80 22.00 1.00 11.61233911

48 21 2 4 1 5.40 20.00 3.00 11.39983964

48 21 2 5 1 6.50 22.00 2.00 11.78831038

48 21 2 6 2 5.20 11.00 12.00 6.349286203

48 21 2 7 2 5.70 10.00 12.00 5.598113698

48 21 2 8 2 6.20 12.00 6.532067785

55 21 4 1 2 6.70 11.00 12.00 5.834913438

55 21 4 2 2 6.40 12.00 12.00 6.46330407

56 21 4 1 1 5.40 19.00 3.00 10.82984766

56 21 4 2 1 5.20 19.00 2.00 10.9669489

56 21 4 3 1 5.20 18.00 3.00 10.38974106

56 21 4 4 1 5.50 19.00 2.00 10.76381036

56 21 4 5 2 5.30 11.00 12.00 6.309099771

56 21 4 6 2 5.50 10.00 13.00 5.665163349

56 21 4 7 2 5.20 10.00 12.00 5.772078366

56 21 4 8 2 5.20 11.00 13.00 6.349286203

56 21 4 9 2 4.00 9.00 12.00 5.669644725

56 21 4 10 2 5.40 11.00 12.00 6.269911804

56 21 4 11 2 5.20 9.00 5.19487053

59 21 5 1 1 6.70 20.00 3.00 10.60893352

59 21 5 2 1 6.50 18.00 3.00 9.644981217

59 21 5 3 1 6.60 20.00 3.00 10.66224564

59 21 5 4 1 6.30 19.00 4.00 10.28742664

59 21 5 5 1 6.10 18.00 1.00 9.851353276

59 21 5 6 1 6.30 19.00 3.00 10.28742664

59 21 5 7 1 6.60 20.00 1.00 10.66224564

59 21 5 8 2 5.80 10.00 12.00 5.565753937

59 21 5 9 2 6.10 10.00 12.00 5.472974042

59 21 5 10 2 5.60 10.00 13.00 5.631239402

59 21 5 11 2 6.10 11.00 12.00 6.020271446

60 21 5 1 1 5.40 20.00 5.00 11.39983964

60 21 5 2 1 4.10 17.00 4.00 10.62154359

26

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29

29

29

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29

29
Birth and lactation data - Individual data from Boberg et al 2010 study (HERO ID 806135)

Group 1 = control; group 2 = DINP-300; group 3 = DINP-600; group 4 = DINP-750; group 5 = DINP-900

Dams dosed by gavage

page 9 of 19

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A B C D E F G H I J K L M

Litter Block Group Pup 

Number Sex Birth weight male AG male Birth weight female AG female Nipples male Nipples female AGI male AGI female

60 21 5 3 1 5.80 20.00 3.00 11.13150787

60 21 5 4 1 5.60 18.00 10.13623092

60 21 5 5 2 4.50 10.00 13.00 6.057068643

60 21 5 6 2 5.40 11.00 12.00 6.269911804

60 21 5 7 2 5.70 11.00 13.00 6.157925068

60 21 5 8 2 5.60 10.00 5.631239402

61 22 1 1 1 6.70 21.00 1.00 11.1393802

61 22 1 2 1 6.60 20.00 2.00 10.66224564

61 22 1 3 1 6.80 21.00 3.00 11.08450552

61 22 1 4 1 7.10 20.00 2.00 10.40584165

61 22 1 5 1 6.70 22.00 1.00 11.66982688

61 22 1 6 1 6.30 20.00 2.00 10.82887014

61 22 1 7 2 6.30 11.00 13.00 5.955878579

61 22 1 8 2 5.60 11.00 12.00 6.194363342

61 22 1 9 2 6.20 10.00 12.00 5.443389821

61 22 1 10 2 6.30 11.00 12.00 5.955878579

62 22 1 1 1 6.40 19.00 1.00 10.23356478

62 22 1 2 1 6.20 19.00 3.00 10.34244066

62 22 1 3 1 6.40 20.00 1.00 10.77217345

62 22 1 4 1 5.80 18.00 2.00 10.01835709

62 22 1 5 1 6.50 20.00 1.00 10.7166458

62 22 1 6 1 6.00 20.00 1.00 11.00642416

62 22 1 7 2 6.00 10.00 12.00 5.503212081

62 22 1 8 2 5.70 10.00 12.00 5.598113698

63 22 1 1 1 6.80 20.00 2.00 10.55667192

63 22 1 2 1 7.30 22.00 1.00 11.3409228

63 22 1 3 2 6.40 11.00 13.00 5.924695398

63 22 1 4 2 6.70 11.00 12.00 5.834913438

64 22 1 1 1 6.60 22.00 3.00 11.72847021

64 22 1 2 1 6.30 21.00 2.00 11.37031365

64 22 1 3 1 6.60 22.00 2.00 11.72847021

64 22 1 4 1 5.90 16.00 3.00 8.854607443

64 22 1 5 2 5.60 11.00 13.00 6.194363342

64 22 1 6 2 6.00 11.00 13.00 6.05353329

64 22 1 7 2 5.40 11.00 13.00 6.269911804

64 22 1 8 2 6.00 10.00 12.00 5.503212081

64 22 1 9 2 5.70 11.00 13.00 6.157925068

298

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330

331

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333

334
Birth and lactation data - Individual data from Boberg et al 2010 study (HERO ID 806135)

Group 1 = control; group 2 = DINP-300; group 3 = DINP-600; group 4 = DINP-750; group 5 = DINP-900

Dams dosed by gavage

page 10 of 19

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A B C D E F G H I J K L M

Litter Block Group Pup 

Number Sex Birth weight male AG male Birth weight female AG female Nipples male Nipples female AGI male AGI female

67 22 2 1 1 6.30 19.00 2.00 10.28742664

67 22 2 2 1 6.40 21.00 1.00 11.31078212

67 22 2 3 1 5.90 20.00 2.00 11.0682593

67 22 2 4 2 5.00 10.00 12.00 5.848035476

67 22 2 5 2 6.40 11.00 12.00 5.924695398

67 22 2 6 2 6.20 11.00 13.00 5.987728803

67 22 2 7 2 5.40 10.00 12.00 5.699919822

67 22 2 8 2 6.00 10.00 13.00 5.503212081

68 22 2 1 1 6.10 21.00 1.00 11.49324549

68 22 2 2 1 6.30 21.00 1.00 11.37031365

68 22 2 3 1 6.50 10.00 2.00 5.358322898

68 22 2 4 1 6.30 21.00 3.00 11.37031365

68 22 2 5 1 6.20 22.00 4.00 11.97545761

68 22 2 6 2 5.90 10.00 12.00 5.534129652

68 22 2 7 2 6.10 10.00 12.00 5.472974042

68 22 2 8 2 6.20 11.00 12.00 5.987728803

69 22 3 1 1 6.30 17.00 4.00 9.204539623

69 22 3 2 1 6.00 16.00 4.00 8.80513933

69 22 3 3 1 6.50 18.00 4.00 9.644981217

69 22 3 4 2 6.40 9.00 13.00 4.847478053

69 22 3 5 2 6.30 10.00 12.00 5.414435072

69 22 3 6 2 5.80 9.00 12.00 5.009178543

69 22 3 7 2 6.60 10.00 12.00 5.331122821

69 22 3 8 2 6.10 10.00 13.00 5.472974042

69 22 3 9 2 6.00 10.00 13.00 5.503212081

69 22 3 10 2 6.00 11.00 12.00 6.05353329

70 22 3 1 1 6.20 17.00 2.00 9.253762696

70 22 3 2 1 6.10 19.00 4.00 10.39865068

70 22 3 3 2 6.20 10.00 13.00 5.443389821

70 22 3 4 2 6.10 11.00 12.00 6.020271446

70 22 3 5 2 6.20 10.00 13.00 5.443389821

71 22 3 1 1 6.50 18.00 2.00 9.644981217

71 22 3 2 1 6.30 20.00 4.00 10.82887014

71 22 3 3 1 6.70 20.00 4.00 10.60893352

71 22 3 4 1 6.60 21.00 4.00 11.19535792

71 22 3 5 2 6.40 11.00 12.00 5.924695398

71 22 3 6 2 5.20 9.00 13.00 5.19487053

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353

354

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359

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361

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367

368

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370

371
Birth and lactation data - Individual data from Boberg et al 2010 study (HERO ID 806135)

Group 1 = control; group 2 = DINP-300; group 3 = DINP-600; group 4 = DINP-750; group 5 = DINP-900

Dams dosed by gavage

page 11 of 19

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A B C D E F G H I J K L M

Litter Block Group Pup 

Number Sex Birth weight male AG male Birth weight female AG female Nipples male Nipples female AGI male AGI female

71 22 3 7 2 5.90 10.00 12.00 5.534129652

71 22 3 8 2 6.40 11.00 13.00 5.924695398

71 22 3 9 2 5.90 10.00 12.00 5.534129652

71 22 3 10 2 5.70 11.00 12.00 6.157925068

71 22 3 11 2 6.10 11.00 13.00 6.020271446

71 22 3 12 2 6.00 11.00 12.00 6.05353329

72 22 3 1 1 6.10 22.00 2.00 12.04054289

72 22 3 2 1 6.40 22.00 4.00 11.8493908

72 22 3 3 1 6.10 20.00 4.00 10.94594808

72 22 3 4 1 6.40 21.00 3.00 11.31078212

72 22 3 5 1 6.20 22.00 2.00 11.97545761

72 22 3 6 2 6.30 12.00 13.00 6.497322087

72 22 3 7 2 5.30 11.00 12.00 6.309099771

72 22 3 8 2 5.90 11.00 12.00 6.087542617

72 22 3 9 2 5.90 11.00 12.00 6.087542617

72 22 3 10 2 5.90 11.00 12.00 6.087542617

72 22 3 11 2 5.90 12.00 12.00 6.640955582

73 22 4 1 1 6.40 18.00 4.00 9.694956105

73 22 4 2 1 6.20 18.00 4.00 9.798101678

73 22 4 3 1 6.60 22.00 3.00 11.72847021

73 22 4 4 1 6.80 21.00 2.00 11.08450552

73 22 4 5 2 5.90 12.00 12.00 6.640955582

73 22 4 6 2 5.80 11.00 12.00 6.12232933

73 22 4 7 2 5.90 10.00 13.00 5.534129652

73 22 4 8 2 5.70 11.00 12.00 6.157925068

73 22 4 9 2 5.40 10.00 12.00 5.699919822

73 22 4 10 2 5.90 11.00 13.00 6.087542617

73 22 4 11 2 5.90 12.00 12.00 6.640955582

74 22 4 1 1 5.80 19.00 4.00 10.57493248

74 22 4 2 1 6.30 20.00 1.00 10.82887014

74 22 4 3 1 5.90 21.00 2.00 11.62167227

74 22 4 4 1 5.80 19.00 4.00 10.57493248

74 22 4 5 1 5.80 20.00 3.00 11.13150787

74 22 4 6 1 6.50 19.00 8.00 10.18081351

74 22 4 7 2 5.60 11.00 12.00 6.194363342

74 22 4 8 2 5.80 12.00 13.00 6.678904724

74 22 4 9 2 6.10 11.00 12.00 6.020271446

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408
Birth and lactation data - Individual data from Boberg et al 2010 study (HERO ID 806135)

Group 1 = control; group 2 = DINP-300; group 3 = DINP-600; group 4 = DINP-750; group 5 = DINP-900

Dams dosed by gavage

page 12 of 19

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A B C D E F G H I J K L M

Litter Block Group Pup 

Number Sex Birth weight male AG male Birth weight female AG female Nipples male Nipples female AGI male AGI female

74 22 4 10 2 5.60 12.00 12.00 6.757487283

74 22 4 11 2 5.70 11.00 12.00 6.157925068

74 22 4 12 2 5.40 10.00 12.00 5.699919822

74 22 4 13 2 5.70 10.50 13.00 5.878019383

76 22 4 1 1 6.80 18.00 5.00 9.501004728

76 22 4 2 1 6.90 19.00 5.00 9.980153876

76 22 4 3 1 6.40 21.00 2.00 11.31078212

76 22 4 4 1 6.90 22.00 6.00 11.55596765

76 22 4 5 2 6.10 12.00 12.00 6.567568851

76 22 4 6 2 5.60 11.00 12.00 6.194363342

76 22 4 7 2 6.30 11.00 12.00 5.955878579

76 22 4 8 2 6.40 10.00 12.00 5.386086725

76 22 4 9 2 6.20 11.00 13.00 5.987728803

78 22 5 1 1 6.10 17.00 4.00 9.304055872

78 22 5 2 1 6.80 19.00 3.00 10.02883832

78 22 5 3 1 6.30 18.00 3.00 9.74598313

78 22 5 4 1 6.70 22.00 1.00 11.66982688

78 22 5 5 2 6.20 11.00 13.00 5.987728803

78 22 5 6 2 6.60 12.00 12.00 6.397347386

78 22 5 7 2 5.70 9.00 13.00 5.038302328

78 22 5 8 2 6.20 10.00 14.00 5.443389821

78 22 5 9 2 6.30 10.00 12.00 5.414435072

78 22 5 10 2 6.10 12.00 13.00 6.567568851

78 22 5 11 2 6.40 11.00 12.00 5.924695398

80 22 5 1 1 6.60 18.00 4.00 9.596021078

80 22 5 2 1 6.80 20.00 4.00 10.55667192

80 22 5 3 1 6.40 20.00 5.00 10.77217345

80 22 5 4 1 6.30 21.00 5.00 11.37031365

Litter means

4 11 1 8.5 1.50 5.83 21.38 5.51 11.63 2.38 12.14 11.89 6.58

7 11 2 5 1.56 6.40 24.25 5.82 12.60 1.25 12.20 13.06 7.01

8 11 2 5.5 1.40 6.42 22.17 6.23 12.25 1.17 12.25 11.93 6.66

11 11 3 5.5 1.10 5.63 21.67 5.50 11.00 3.38 12.00 12.20 6.23

12 11 3 6 1.64 5.58 22.00 5.57 12.07 2.25 12.00 12.42 6.82

16 11 4 6.5 1.50 6.12 20.83 5.78 10.83 4.33 12.00 11.40 6.04

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436

437

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439

440

441

442

443

444

445
Birth and lactation data - Individual data from Boberg et al 2010 study (HERO ID 806135)

Group 1 = control; group 2 = DINP-300; group 3 = DINP-600; group 4 = DINP-750; group 5 = DINP-900

Dams dosed by gavage

page 13 of 19

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A B C D E F G H I J K L M

Litter Block Group Pup 

Number Sex Birth weight male AG male Birth weight female AG female Nipples male Nipples female AGI male AGI female

19 11 5 4 1.71 6.35 20.50 6.04 10.80 4.00 12.40 11.07 5.94

20 11 5 2.5 1.75 5.20 22.00 5.43 11.67 4.00 12.00 12.70 6.64

21 12 1 7 1.54 6.32 24.50 6.14 12.14 3.33 12.43 13.25 6.63

24 12 1 7 1.54 6.28 23.40 5.99 12.25 0.80 12.13 12.69 6.75

25 12 2 3 2.00 5.88 11.50 12.33 6.37

26 12 2 4 1.71 6.35 21.00 5.68 12.20 2.50 12.60 11.35 6.84

28 12 2 6 1.73 6.40 21.00 5.81 10.63 3.00 12.25 11.31 5.92

29 12 3 7 1.31 6.04 19.22 6.03 10.50 1.57 12.50 10.57 5.77

30 12 3 4.5 1.13 6.51 23.57 6.50 13.00 2.86 12.00 12.64 6.97

31 12 3 6 1.55 6.12 21.10 5.93 11.17 2.40 12.33 11.54 6.17

32 12 3 4.5 1.25 6.15 22.83 6.40 14.00 3.17 12.50 12.46 7.54

33 12 4 7 1.54 5.58 20.50 5.59 10.71 3.83 12.29 11.56 6.04

35 12 4 3.5 1.50 6.33 22.33 6.17 13.00 1.00 12.33 12.08 7.09

36 12 4 5 1.67 6.50 23.50 6.12 12.20 2.00 12.40 12.59 6.68

37 12 5 8 1.00 6.00 21.67 5.57 11.83 3.33 12.33 11.93 6.68

38 12 5 5 1.11 5.55 17.25 5.80 10.00 2.00 12.00 9.75 5.57

39 12 5 5 1.78 6.50 20.50 5.87 10.57 2.00 12.29 10.98 5.86

40 12 5 6.5 1.42 5.63 19.67 5.72 10.00 3.00 12.40 11.06 5.59

43 21 1 4 2.00 5.87 9.86 12.14 5.47

47 21 2 6.5 1.42 6.06 21.14 6.08 11.00 2.43 12.20 11.61 6.03

48 21 2 4.5 1.38 6.26 20.20 5.70 11.00 1.80 12.00 10.97 6.16

55 21 4 1.5 2.00 6.55 11.50 12 6.149108754

56 21 4 6 1.64 5.33 18.75 5.11 10.14 2.50 12.33 10.74 5.89

59 21 5 6 1.36 6.44 19.14 5.90 10.25 2.57 12.25 10.29 5.67

60 21 5 4.5 1.50 5.23 18.75 5.30 10.50 4.00 12.67 10.82 6.03

61 22 1 5.5 1.40 6.70 20.67 6.10 10.75 1.83 12.25 10.97 5.89

62 22 1 4.5 1.25 6.22 19.33 5.85 10.00 1.50 12.00 10.51 5.55

63 22 1 2.5 1.50 7.05 21.00 6.55 11.00 1.50 12.50 10.95 5.88

64 22 1 5 1.56 6.35 20.25 5.74 10.80 2.50 12.80 10.92 6.04

67 22 2 4.5 1.63 6.20 20.00 5.80 10.40 1.67 12.40 10.89 5.79

68 22 2 4.5 1.38 6.28 19.00 6.07 10.33 2.20 12.00 10.31 5.66

69 22 3 5.5 1.70 6.27 17.00 6.17 9.86 4.00 12.43 9.22 5.38

70 22 3 3 1.60 6.15 18.00 6.17 10.33 3.00 12.67 9.83 5.64

71 22 3 6.5 1.67 6.53 19.75 5.95 10.50 3.50 12.38 10.57 5.79

72 22 3 6 1.55 6.24 21.40 5.87 11.33 3.00 12.17 11.62 6.29

73 22 4 6 1.64 6.50 19.75 5.79 11.00 3.25 12.29 10.58 6.13

74 22 4 7 1.54 6.02 19.67 5.70 11.07 3.67 12.29 10.82 6.20

446

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473

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477

478

479

480

481

482
Birth and lactation data - Individual data from Boberg et al 2010 study (HERO ID 806135)

Group 1 = control; group 2 = DINP-300; group 3 = DINP-600; group 4 = DINP-750; group 5 = DINP-900

Dams dosed by gavage

page 14 of 19

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A B C D E F G H I J K L M

Litter Block Group Pup 

Number Sex Birth weight male AG male Birth weight female AG female Nipples male Nipples female AGI male AGI female

76 22 4 5 1.56 6.75 20.00 6.12 11.00 4.50 12.20 10.59 6.02

78 22 5 6.50 1.70 6.60 19.67 6.21 10.71 2.33 12.71 10.48 5.82

80 22 5 2.5 1.00 6.53 19.75 4.50

AG = Anogenital distance measured in arbitrary units

AGI = Anogenital index, AG divided by cube root of the body weight

Group means 

based on 

litter means 1.00 21.50 5.97 11.05 1.98 12.30 11.60 6.10

2.00 6.30 21.09 5.90 11.32 2.00 12.25 11.43 6.27

Control 3.00 6.12 20.65 6.01 11.38 2.91 12.30 11.31 6.26

DINP-300 4.00 6.14 20.67 5.88 11.27 3.14 12.24 11.29 6.25

DINP-600 5.00 6.00 19.89 5.76 10.70 3.17 12.34 11.01 5.98

DINP-750

DINP-900

0.39 1.82 0.31 0.90 0.83 0.26 1.04 0.50

Standard 

deviation 0.12 1.58 0.19 0.85 0.64 0.19 0.82 0.48

Control 0.32 2.11 0.32 1.30 0.69 0.24 1.20 0.67

DINP-300 0.49 1.55 0.41 0.86 1.21 0.14 0.75 0.38

DINP-600 0.56 1.39 0.29 0.66 0.92 0.25 0.88 0.41

DINP-750

DINP-900

483

484

485

486

487

488

489

490

491

492

493

494

495

496

497

498

499

500

501

502
Motility

Individual data from Boberg et al 2010 study (HERO ID 806135)

page 15 of 19

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A B C D E F G H I J K L

Animal 

number Group Litter Motile sperm

(%)

Progressive 

sperm

(%)

AP vel. SL vel. CL vel. STR Sperm/g Cauda (g) Sperm 

count

201 Control 4 58 28 157.8 92.3 298.6 58 374.8 0.2182 81.78136

202 Control 4 53 27 141.1 83.4 278.3 58 315.4 0.2403 75.79062

211 Control 24 61 31 170 107.5 342.3 62 518.2 0.242 75.0926

212 Control 24 54 27 165.5 100.4 333.5 59 379.6 0.1978 94.7462

221 Control 21 55 22 177.1 105.7 324.9 58 504.9 0.2118 109.75476

222 Control 21 59 25 163.2 85.2 334 56 310.3 0.2475 93.951

223 Control 21 40 25 161.9 98.9 327.1 61 479 0.2476 125.01324

224 Control 24 62 34 164.8 98.7 343.8 61 367.5 0.234 85.995

251 Control 61 70 43 169.8 101.7 355.9 61 389.5 0.2136 83.1972

252 Control 61 63 43 158.6 98.1 325 62 483.6 0.28 135.408

257 Control 61 67 45 178 114.8 353.7 65 334.2 0.2467 82.44714

258 Control 62 64 37 166.2 104 331.1 63 506 0.2287 115.7222

265 Control 64 67 34 171.5 107.2 333.6 62 381.4 0.2292 108.6408

266 Control 64 61 31 168.4 96.7 366 58 377.1 0.2035 134.2286

275 Control 62 58 29 158 93.9 316.2 60 474 0.2192 83.60288

276 Control 62 56 34 168.7 100.4 358.1 61 659.6 0.2123 80.05833

203 DINP 300 7 41 21 151 84.5 309.5 57 338.9 0.2214 75.03246

204 DINP 300 7 61 36 169.6 104.7 329 61 531.5 0.204 108.426

213 DINP 300 8 59 31 138.6 81.3 302 60 402.5 0.2411 97.04275

214 DINP 300 8 53 29 166.4 104.8 338.1 62 527.1 0.2223 117.17433

225 DINP 300 8 48 32 143.9 87.8 317 63 550.9 0.1929 106.26861

226 DINP 300 28 52 28 167.6 98.9 343 58 513.1 0.217 111.3427

241 DINP 300 47 62 39 175.1 113.3 347.4 63 466.6 0.21 97.986

242 DINP 300 47 65 35 173.8 104.1 341.3 59 447.5 0.2005 89.72375

245 DINP 300 47 65 38 166.4 103.7 331.9 62 481.5 0.2143 103.18545

246 DINP 300 48 59 32 187.5 112.7 378.6 61 484 0.2235 108.174

249 DINP 300 48 61 35 172.1 107.6 352.2 63 493.8 0.2551 125.96838

250 DINP 300 48 58 36 170.2 104.9 353 62 492.7 0.2331 114.84837

253 DINP 300 67 65 39 139.2 81.8 296.7 60 538.9 0.2262 121.89918

254 DINP 300 68 65 41 156.9 96.9 332.9 63 424 0.1815 76.956

259 DINP 300 68 54 34 174.8 107.2 367.3 62 379.4 0.1749 66.35706

260 DINP 300 68 47 31 161.5 99.7 351.1 61 524.1 0.1868 97.90188

205 DINP 600 11 66 37 192.8 115.7 382.3 59 486.9 0.2401 116.90469

206 DINP 600 11 54 28 168.9 104.9 353.8 62 396.1 0.2308 91.41988

215 DINP 600 12 46 24 154.2 95.6 301.8 63 366.7 0.2169 79.53723

216 DINP 600 12 52 20 170.3 87.2 338.2 53 466.7 0.1779 83.02593
Motility

Individual data from Boberg et al 2010 study (HERO ID 806135)

page 16 of 19

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A B C D E F G H I J K L

227 DINP 600 29 43 14 161.5 91 322.8 54 531.6 0.2253 119.76948

228 DINP 600 29 46 26 156.2 96.6 313.7 60 574.4 0.2431 139.63664

231 DINP 600 30 53 28 162.8 108.3 310.3 67 289 0.2691 77.7699

232 DINP 600 30 66 35 166.7 99.4 317.9 61 500.8 0.2224 111.37792

235 DINP 600 31 33 14 158.9 86.8 303.1 58 535.4 0.2134 114.25436

236 DINP 600 31 49 24 144.3 85.9 302.3 60 362.9 0.2213 80.30977

239 DINP 600 32 43 27 153.4 92.4 327.7 62 403.7 0.2122 85.66514

240 DINP 600 32 55 38 156.1 94.4 349.3 63 464.8 0.21 97.608

267 DINP 600 69 55 41 171.5 112.6 362.7 66 461.4 0.2486 114.70404

268 DINP 600 70 51 27 151.7 89.2 317.7 59 431.9 0.2489 107.49991

271 DINP 600 71 53 33 173.4 108 333.7 61 547.9 0.1877 102.84083

272 DINP 600 72 55 29 170.1 102.5 355.5 60 473.4 0.2351 111.29634

207 DINP 750 16 54 29 154.4 98.9 312.7 64 358.8 0.2384 85.53792

208 DINP 750 16 47 18 156 84.2 327.7 55 486.1 0.2263 110.00443

217 DINP 750 35 47 20 160.1 91.7 332.6 58 465 0.2147 92.9651

218 DINP 750 33 47 21 162.5 92.9 331.5 57 433.5 0.2341 108.8565

219 DINP 750 33 50 26 159.3 96.4 326.6 61 306.7 0.1868 80.9778

220 DINP 750 33 41 21 150.9 87.2 306.2 59 433 0.22 67.474

255 DINP 750 56 11 6 148.8 110.1 314.5 71 181.5 0.1216 22.0704

256 DINP 750 56 55 29 173.3 112.6 335.9 64 508.8 0.2184 111.12192

261 DINP 750 73 63 34 146.2 89.2 305.9 61 510 0.2244 114.444

262 DINP 750 73 43 20 145.3 89.4 307.4 61 387.2 0.2377 92.03744

269 DINP 750 74 60 34 163.6 99.8 331.3 59 529.5 0.1979 104.78805

270 DINP 750 74 54 31 161.4 92.2 350 57 441.4 0.2467 108.89338

273 DINP 750 76 51 32 145.4 89.5 324.6 62 463.2 0.2001 92.68632

209 DINP 900 19 37 19 153 81.6 335.5 56 478.8 0.199 95.2812

210 DINP 900 37 46 27 182.1 118.2 380.2 65 507.9 0.2008 101.98632

229 DINP 900 38 58 38 144.6 86.9 293.4 63 516.2 0.2131 110.00222

230 DINP 900 38 53 21 140.2 71.8 300.7 54 508.3 0.2298 116.80734

233 DINP 900 38 38 24 135.9 78.7 302.8 60 441.3 0.2244 99.02772

234 DINP 900 40 50 23 169 107 347.6 60 501.7 0.2042 102.44714

237 DINP 900 40 62 31 162.7 99.7 326 60 552.5 0.2352 129.948

238 DINP 900 40 43 19 150.7 80.3 310.4 55 505.1 0.1823 92.07973

243 DINP 900 59 58 35 162.7 102 339.1 64 661.1 0.2238 147.95418

244 DINP 900 59 43 27 164.2 98.4 367.4 61 491.3 0.2082 102.28866

247 DINP 900 59 60 33 160.2 94.5 331.6 59 346 0.2151 74.4246

248 DINP 900 60 43 25 181.1 104.9 382.8 59 500 0.2147 107.35

263 DINP 900 78 48 26 160 94.1 342.5 59 443.5 0.2325 103.11375

264 DINP 900 78 53 31 169.8 98.9 362.1 59 537 0.2157 115.8309
Motility

Individual data from Boberg et al 2010 study (HERO ID 806135)

page 17 of 19

77

78

79

80

81

82

83

84

85

86

87

88

89

90

91

92

93

94

95

96

97

98

99

100

101

102

103

104

105

106

107

108

109

A B C D E F G H I J K L

Animal 255: Both left and right epididymis and testes are very small. Very few motile sperm.

Group mean values

motile 

sperm 

(%)

progressive 

sperm

(%)

average path 

velocity

straight line 

velocity

curvilinear 

velocity

straightnesssperm/

gram

cauda sperm 

count

Control 59.25 32.19 165.04 99.31 332.63 60.31 428.44 0.23 97.84

DINP 300 57.19 33.56 163.41 99.62 336.94 61.06 474.78 0.21 101.14

DINP 600 51.25 27.81 163.30 98.16 330.80 60.50 455.85 0.23 102.10

DINP 750 47.92 24.69 155.94 94.93 323.61 60.69 423.44 0.21 91.68

DINP 900 49.43 27.07 159.73 94.07 337.29 59.57 499.34 0.21 107.04

Standard deviation

Control 7.09 6.94 8.79 8.08 22.36 2.33 93.80 0.02 20.73

DINP 300 7.34 5.02 13.98 10.41 22.52 1.84 61.51 0.02 17.08

DINP 600 8.25 7.82 11.49 9.55 24.16 3.65 77.20 0.02 17.87

DINP 750 12.74 8.01 8.46 8.53 13.41 4.11 96.36 0.03 25.14

DINP 900 8.16 5.86 13.83 12.81 28.97 3.16 68.71 0.01 17.44

Litter has been included in the statistical analysis as a random factor in the ANOVA test

Statistical analysis has been performed both with and without animal number 255

CONTROL GROUP

Litter label 

number Litter Mean Mean of 

litters

Standard 

Deviation of 

litters

4 55.50 59.31 5.56

24 59.00

21 51.33

61 66.67

62 59.33

64 64.00

DINP 300

Litter label 

number Litter Mean Mean of 

litters

Standard 

deviation of 

litters

7 51.00 56.78 6.16

8 53.33
Motility

Individual data from Boberg et al 2010 study (HERO ID 806135)

page 18 of 19

110

11

21

31

41

51

61

71

28 52.00

47 64.00

67 65.00

68 55.33

DINP 600

Litter label 

number Litter Mean Mean of 

litters

Standard 

Deviation of 

litters

11 60.00 51.70 6.10

12 49.00

29 44.50

30 59.50

31 41.00

32 49.00

69 55

70 51

71 53

72 55

DINP 750

Litter label 

number Litter Mean Mean of 

litters

Standard 

Deviation of 

litters

16 50.50 48.21 7.65

35 47.00

33 46.00

56 33.00

73 53.00

74 57.00

76 51

or without animal 255 in litter labeled 56

Animal 255: Both left and right epididymis and testes are very small. Very few motile sperm.

16 50.50 51.36 4.01

35 47.00

33 46.00

56 55.00

73 53.00

81

91

02

12

22

32

42

52

62

72

82

92

03

13

23

33

43

53

63

73

83

93

04

14

24

34

44

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

A B C D E F G H I J K L
Motility

Individual data from Boberg et al 2010 study (HERO ID 806135)

page 19 of 19

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153

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A B C D E F G H I J K L

74 57.00

76 51

DINP 900

Litter label 

number Litter Mean Mean of 

litters

Standard 

Deviation of 

litters

19 37.00 46.31 5.57

37 46.00

38 49.67

40 51.67

60 43.00

78 50.5
Testis histology data from Boberg et al 2010 study (HERO ID 806135)

Dose group Litter number pup number MNG GC change chord diameter increase

1 1 e 0 0 0

1 1 h 0 0 0

1 41 f 0 0 0

1 42 j 0 0 0

1 42 f 0 0 0

1 42 k 0 0 0

1 42 h 0 0 0

2 5 h 1 0 0

2 6 e 0 0 0

2 6 k 0 0 0

2 6 j 0 0 0

2 6 h 0 0 0

2 45 g 0 0 0

2 45 d 1 0 0

2 46 g 0 0 0

3 9 f 1 0 0

3 9 c 0 0 0

3 10 h 1 0 0

3 10 e 0 1 1

3 52 f 1 1 1

4 14 i 1 1 0

4 15 l 1 1 0

4 15 h 0 0 0

4 53 j 1 1 1

4 53 p 1 1 1

4 53 e 1 1 1

4 53 i 1 1 1

5 17 g 1 1 1

5 17 i 1 1 1

5 17 c 1 0 0

5 17 e 1 1 0

5 18 d 1 0 0

5 58 c 1 1 1

total number 

single animals of pups MNG GC change chord diameter increase

1 7 0 0 0

2 8 2 0 0

3 5 3 2 2

4 7 6 6 4

5 6 6 4 3

litters total number of MNG GC change chord diameter increase

1 3 0 0 0

2 4 2 0 0

3 3 3 2 2

4 3 3 3 1

5 3 3 2 2
Testosterone production data from Boberg et al 2010 study (HERO ID 806135)

Dose group Litter number Pup number Testicular testosterone production

1 41 e 1.16

1 41 c 2.16

1 42 c 0.58

1 42 e 0.82

1 1 b 1.16

1 1 c 9.16

2 45 a 0.94

2 45 b 2.30

2 46 d 1.25

2 46 e 1.51

2 5 a 0.75

2 5 d 0.52

2 6 b 1.67

2 6 d 0.79

3 51 a 0.44

3 51 b 0.21

3 52 c 0.33

3 52 e 0.73

3 9 a 0.66

3 9 b 0.43

3 10 b 1.79

3 10 d 0.55

4 53 a 0.06

4 53 b 0.15

4 54 f 2.10

4 54 c 0.59

4 14 a 1.38

4 14 g 1.11

4 15 b 0.46

4 15 c 0.43

5 57 b 0.31

5 57 d 0.05

5 58 a 1.94

5 58 b 0.16

5 17 a 0.36

5 17 b 0.23

5 18 a 0.86

5 18 b

Control

litter label # Litter Mean mean of litters SD of litters

41.00 1.66 2.51 2.35

42.00 0.70

1.00 5.16

DINP 300

litter label # Litter Mean mean of litters SD of litters

45 1.62 1.22 0.42

46 1.38

5 0.64

6 1.23

DINP 600

51 0.32 0.64 0.37

52 0.53

9 0.54

10 1.17

DINP 750

53 0.11 0.78 0.61

54 1.35

14 1.25

15 0.44

DINP 900

litter label # Litter Mean mean of litters SD of litters

57 0.18 0.60 0.42

58 1.05

17 0.30

18 0.86
Testosterone content data from Boberg et al 2010 study (HERO ID 806135)

Dose group Litter number animal number nM ng per testis

1 1 e 80.1 11.5344

1 1 f 59.4 8.5536

1 41 k 46.9 6.7536

1 41 f 81 11.664

1 42 g 37.5 5.4

1 42 f 61.2 8.8128

2 5 h 53.7 7.7328

2 6 e 36.7 5.2848

2 6 g 52.5 7.56

2 45 e 43 6.192

2 45 d 66.6 9.5904

2 46 g 58.4 8.4096

3 9 c 39.9 5.7456

3 9 e 45.7 6.5808

3 10 e 38.5 5.544

3 10 g 45.1 6.4944

3 51 c 31.2 4.4928

3 52 f 5.8 0.83952

4 14 i 46.8 6.7392

4 15 h 67.7 9.7488

4 15 j 49.4 7.1136

4 53 d 18.1 2.6064

4 53 c 25.9 3.7296

5 17 c 35.5 5.112

5 17 h 33.4 4.8096

5 18 d 28.5 4.104

5 18 e 52.2 7.5168

5 58 d 20.2 2.9088

5 58 c 58.4 8.4096