Clinical Development and License Agreement



 Exhibit 10.3 
 AMENDMENT NO. 2 dated as of May 16, 2006 to that certain Clinical Development and License Agreement dated as of July 14, 2005 between BioDelivery Sciences International, Inc (“BDSI”), Arius Pharmaceuticals, Inc., a
wholly-owned subsidiary of BDSI (“Arius”, and together with BDSI, the “Company”) and CDC IV, LLC, a Delaware limited liability company and assignee of Clinical Development Capital LLC (“CDC”) (as the same may be
amended, supplemented or otherwise modified, the “Development Agreement”). 
 INTRODUCTORY STATEMENT 
 Reference is made to the Development Agreement concerning the development of a product containing or comprising of fentanyl in conjunction with BEMA
Technology. 
 In order to facilitate its performance of its obligations under the Development Agreement and to reduce certain financial
obligations on the part of BDSI under the Development Agreement, Company has requested and CDC has agreed that a certain milestone payment to be made to CDC in connection with Approval of the Product be eliminated in consideration of: (i) BDSI
issuing certain securities to CDC pursuant to that certain Securities Purchase Agreement dated the date hereof (the “Purchase Agreement”) by and between CDC and BDSI; and (ii) certain other amendments to the Development Agreement as
set forth herein. 
 Accordingly, Company and CDC have agreed to amend the Development Agreement, all on the terms and subject to the
conditions hereinafter set forth. 
 Therefore, the parties hereto hereby agree as follows: 
 Section 1. Defined Terms. Capitalized terms used herein and not otherwise defined herein shall have the meaning given them in the Development
Agreement. 
 Section 2. Amendments to the Development Agreement. Subject to the satisfaction of the conditions precedent set
forth in Section 3 hereof, the Development Agreement is hereby amended as of the Effective Date (as hereinafter defined) as follows: 
 (A) Article I of the Development Agreement is hereby amended by amending and restating the definition of “Development Term” as follows: 
 “Development Term” means the period of time from the commencement of the Development Program until the earlier of (a) the termination or expiration of all obligations of Company to make royalty
payments under Section 6.6 of this Agreement, or (b) the Trigger Date. 
 (B) Sections 5.3.1 and 5.3.2 of the Development Agreement
are hereby amended to read in its entirety as follows: 
 5.3.1 License to Program Data. Subject to the terms and conditions of this
Agreement, CDC hereby grants to Company during the period commencing on the Effective 







 Date and ending upon Approval of the initial Product a worldwide, exclusive right and license, with the right to
sublicense to a Qualified Collaboration Partner pursuant to the terms of this Agreement, to use the Program Data to conduct the Development Program, including, without limitation, the submission of an NDA for the Product.” 
 “5.3.2 License to Program Data After Product Approval. CDC hereby grants to Company a worldwide, exclusive right and license, with the right
to sublicense, to use the Program Data to make, have made, use, have used, import, export, offer to sell, sell and have sold Products; provided, however that such license shall only become effective (and Company shall only be permitted to exercise
its rights under the license) upon Company obtaining Approval of the initial Product by the FDA.” 
 (C) Section 6.4.1 of the
Development Agreement is hereby amended and restated to read in its entirety as follows and the parties hereto acknowledge and agree that CDC has no further payment obligations under the Development Agreement: 
 “6.4.1 Trial Participants. Commencing at the end of the third full calendar month following the first patient enrollment with respect to such
Phase III Clinical Trial (e.g., if the first patient is enrolled on April 15th, then commencing on July 31st) within five (5) days of the end of such calendar month and each subsequent month, Company shall deliver to CDC a written
notice indicating the actual level of patient recruitment on a cumulative basis participating in such clinical trial as part of the Development Program (the “Actual Trial Participants”). In the event the level of Actual Trial
Participants falls below ninety percent (90%) of the projected cumulative level of patient recruitment for such clinical trial (as set forth in the Development Program) (the “Projected Trial Participants”) in any calendar
month, then Company shall issue to CDC warrants to purchase two hundred (200) shares of Company’s common stock, par value $0.001 per share, with an exercise price per share equal to $3.50, for every percent Actual Trial Participants falls
below 90% (e.g., if the level of Actual Trial Participants is 75% of the Project Trial Participants in a calendar month, then Company shall issue CDC warrants to purchase 3,000 shares of Company’s common stock, par value $0.001 per share) for
each such month. Such warrants shall be promptly issued following each month when the Actual Trial Participants falls below the 90% threshold. Such warrants shall be in the same form as attached hereto as Exhibit I. Notwithstanding anything to the
contrary contained herein, it is expressly understood and agreed to by the Parties that in no event shall Company be obligated to issue, in the aggregate, warrants to purchase in excess of fifty thousand (50,000) shares of Company’s common
stock, par value $0.001 per share. Notwithstanding the foregoing, in the event the NDA is filed and accepted by the FDA on or before June 30, 2007, the parties agree that any warrants issued under this Section 6.4.1 shall immediately
expire. 
 (D) Sections 6.4.5 and 6.4.6 of the Development Agreement are hereby deleted in its entirety. 
 (E) Section 6.5 of the Development Agreement is hereby deleted in its entirety. 
  

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 (F) Section 6.11 of the Development Agreement is hereby amended to read in its entirety as follows:

 “6.11 Consistent Treatment of Transaction by the Parties. It is the intent of the Parties that, for federal, state and local tax (including
sales and use taxes) purposes and commercial and bankruptcy law purposes, that (a) CDC shall be treated as the legal and beneficial owner of the Program Data during the period commencing on the Effective Date and ending on Approval of the
Initial Product, entitled to any and all benefits of ownership, (b) the Development Program shall be performed by Company on behalf of CDC pursuant to the Development Program, and (c) the license pursuant to Section 5.3.2 upon receipt
of Approval of the Initial Product shall be treated as a sale of the Program Data by CDC to Company. Nevertheless, Company acknowledges and agrees that CDC has not made any representations or warranties concerning the tax, financial, accounting or
legal characteristics or treatment of this Agreement, and that Company has obtained and relied solely upon the advice of its own tax, accounting and legal advisors concerning this Agreement and the accounting, tax, financial and legal consequences
of the transactions contemplated herein. 
 (G) The Development Agreement is amended to include a new Exhibit I as set forth on
Exhibit I attached hereto. 
 Section 3. Conditions to Effectiveness. The effectiveness of this Amendment is subject to
the satisfaction of all of the following conditions precedent (the date on which all such conditions have been satisfied being herein called the “Effective Date”): 
 (a) CDC shall have received a fully executed Purchase Agreement, warrant to purchase certain shares of BDSI common stock as set forth in the Purchase
Agreement and Amended and Restated Registration Rights Agreement; 
 (c) CDC shall have received the favorable written opinion, dated the
date of the first Advance hereunder, addressed to CDC of Wyrick Robbins Yates & Ponton LLP, counsel to Company, in form and substance satisfactory to CDC; and 
 (d) the receipt by CDC of counterparts of this Amendment which, when taken together, bear the signatures of CDC and Company. 
 Section 4. Representations and Warranties. Company jointly and severally represents and warrants that after giving effect to this Amendment, the representations and warranties contained in the Development
Agreement are true and correct in all material respects on and as of the date hereof as if such representations and warranties had been made on and as of the date hereof (except to the extent that any such representations and warranties specifically
relate to an earlier date). 
 Section 5. Further Assurances. At any time and from time to time, upon CDC’s request and at
the sole expense of Company, Company will promptly and duly execute and deliver any and all further instruments and documents and take such further action as CDC reasonably deems necessary to effect the purposes of this Amendment. 
 Section 6. Full Force and Effect. Except as expressly amended hereby, the Development Agreement shall continue in full force and effect in
accordance with the provisions thereof on the date hereof. As used in the Development Agreement, the terms “Agreement”, 
  

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 “this Agreement”, “herein”, “hereafter”, “hereto”, “hereof”, and words
of similar import, shall, unless the context otherwise requires, mean the Development Agreement as amended by this Amendment. 
 Section 7. APPLICABLE LAW. THIS AMENDMENT SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK. 
 Section 8. Counterparts. This Amendment may be executed in two or more counterparts, each of which shall constitute an original, but all of which when taken together shall constitute but one instrument.

 Section 9. Headings. The headings of this Amendment are for the purposes of reference only and shall not affect the
construction of or be taken into consideration in interpreting this Amendment. 
  

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 IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed as of the day and
the year first written. 
  

			
	 CDC IV, LLC, as Secured Party

		
	 By
	 	 /s/  Jan Leschly

	 Name:
	 	 Jan Leschly

	 Title:
	 	
	
	 Arius Pharmaceuticals, Inc., as Grantor

		
	 By
	 	 /s/  Mark A. Sirgo

	 Name:
	 	 Mark A. Sirgo

	 Title:
	 	 President

	
	 BIODELIVERY SCIENCES INTERNATIONAL, INC.

		
	 By
	 	 /s/  Mark A. Sirgo

	 Name:
	 	 Mark A. Sirgo

	 Title:
	 	 President and CEO


  

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