### Appendix B. Table of Generic Data Requirements and Studies Used to Make the

**Reregistration Decision for Chloropicrin**  **(PC 081501**  **)** GUIDE TO APPENDIX B Appendix B contains a listing of data requirements which support the reregistration for the active ingredient chloropicrin covered b y this RED. It contains generic data requirements that apply to chloropicrin in all products, including data requirements for which a “ty pical formulation” is the test substance. The data table is organized in the following formats: 1. Data requirement (Column 1). The data requirements are listed in the order in which they

appear in 40 CFR 158. The reference numbers accompanying each test refer to the test protocols set in the Pesticide Assessment Guidance, which is available from the National Technical Information Service, 5285 Port Royal Road, Springfield, VA 22161. (703) 487 -4650. 2. Use Pattern (Column 2). This column indicates the use patterns for which the data requirements apply. The following letter designations are used for the given use patterns. A. Terrestrial food B. Terrestrial feed C. Terrestrial non- food D. Aquatic food E. Aquatic non- food outdoor F. Aquatic non- food industrial G. Aquatic non- food residential H. Greenhouse food I. Greenhouse non- food J. Forestry K. Residential L. Indoor food M. Indoor non- food N. Indoor medical O. Indoor residential 3. Bibliographic Citation (Column 3). If the Agency has acceptable data in its files, this column lists the identifying number of each study . This normally is the Master Record Identification (MRID) number, but may be a “GS” number is no MRID number has been assigned. Refer to the Bibliography appendix for a complete citation of the study .**Data Requirement Use Patterns**  **Citations**

**New Guideline**  **Number Old** 

**Guideline Number**  **Description PRODUCT CHEMISTRY**  830.1550 61 - 1 Product Identity and Composition All 43090201 , 43091301 , 43091401 830.1600 61 -2A Description of materials used to produce the product All 44230001, 43090201 , 43091301 , 43091401 , 42400001, 42400002 830.1620 61 -2B Description of production process All 43090201 , 43091301 , 43091401 , 42400001, 42400002 830.1650 61 -2B Description of formulation process All 44230001 830.1670 61 -2B Formation of Impurities All 43090201 , 43091301 , 43091401 , 42400000 830.1700 62 - 1 Preliminary Analysis All 43097901 , 43137001 , 43091402 , 42400002 830.1750 62 -2 Certification of Limits All 43090202 830.1800 62 - 3 Analytical Method All 43090202 , 43137002 , 43091402 , 43137001 830.6302 63 -2 Color All 43097902 , 43137002 , 43133101 , 42427001 830.6303 63 - 3 Physical State All 43097902 , 43137002 , 43133 1 01 , 42427001 830.6304 63 -4 Odor All 42427001 830.6313 63 - 13 Stability to normal and elevated tem peratures, metals, and metal ions All 43097902 , 43137002 , 43133101 , 42427001 830.6314 63 - 14 Oxidation/reduction: chemical incompatibility All 43434601 830.6315 63 - 15 Flammability All 00013198 830.6317 63 - 17 Storage stability All 00013198 830.6320 63 -20 Corrosion characteristics All 00013198 830.7100 63 - 18 Viscosity All 43434601 830.7220 63 - 6 Boiling Point/boiling range All 43097902 , 43137002 , 4313301 , 42427001 830.7300 63 - 7 Density All 43097902 , 43137002 , 43133101 , 42427001 830.7505 Ultraviolet/visible Absorption All Study called in via the DCI, however EPA granted a waiver request in May 2011. 830.7550 63 - 11 Partition coefficient, shake flask method All 43022402 , 43022402 830.7840 63 - 8 Solubility All 43097902 , 43137002 , 43133101 , 42427001 830.7860 63 - 8 Water solubility, generator column method All 43097902, 43137002, 43133101 , 42427001 , 43613901**Data Requirement Use Patterns**  **Citations**

**New Guideline**  **Number Old** 

**Guideline Number**  **Description** 830.7950 63 - 9 Vapor Pressure All 43097902, 43137002, 43133101 , 42427001 **ECOLOGICAL EFFECTS** 850.1010 72 -2 Acute Toxicity to Freshwater Invertebrates C, I 130704 ( supplemental), data gap submitted 48442401 in resp onse to DCI 850.1025 72 - 3B Estuarine/Marine Toxicity

– Mollusk C, I Data gap

– submitted 48442404 in response to DCI 850.1035 72 - 3C Estuarine/Marine Toxicity

– Shrimp C, I Data gap

– submitted 48442403 in response to DCI 850.1075 72 - 1A Fish Toxicity Bluegill C, I 47102102 (supplemental) 850.1075 72 - 1 B Fish Toxicity Rainbow Trout C, I 47102102 (supplemental) , 43066701 (supplemental) 850.1075 72 - 3A Estuarine/Marine Toxicity

– Fish C, I Data gap

– submitted 48442402 , 48442405, 48442406 in response to DCI 850.3020 141 - 1 Honey bee acute contact LD50 C, I Data gap

– submitted 48442473 in response to DCI 850.4100 122 - 1 Seedling Emergence, Tier 1 C, I Data gap

– submitted 48442802 in response to DCI 850.4150 122 - 1 Vegetative Vigor, Tier 1 C, I Data gap

– submitted 48442802 in response to DCI 850.4400 123 - 2 Aquatic Plant Toxicity C, I Data gap

– submitted 48442801 in response to DCI NonGuideline Study NonGuideline Study Avian Acute Inhalation C, I Data gap

– submitted 48442803 in response to DCI **TOXICOLOGY** 870.1100 81 - 1 Acute Oral Toxicity - Rat C, I 05014376 870.1200 81 -2 Acute Dermal Toxicity

– Rabbit/Rat C, I 05014376 870.1300 81 - 3 Acute Inhalation Toxicity

– Rat /Mouse C, I 45117901 , 45117902 870.2500 81 - 5 Primary Skin Irritation C, I 05014376 870.3465 82 - 5 90 - Day Inhalation Toxicity C, I 43063201 870.3465 82 -4 13 -Week Inhalation

– Mouse/Rat C, I 43063201 870.3700A 83 - 3A Developmental Toxicity

– Rat C, I 42740602 870.3700B 83 - 3B Developmental Toxicity

– Rabbit C, I 42740601 870.3800 83 -4 2 - Generation Reproduction

– Rat C, I 43391901, 46427801 870.4100A 83 - 1 Chronic Toxicity Rodents C, I 43744301**Data Requirement Use Patterns**  **Citations**

**New Guideline**  **Number Old** 

**Guideline Number**  **Description** 870.4100B 83 - 1B Chronic Feeding Toxicity Study - Non-rodent C, I 43196301 870.4200 83 -2 Carcinogenicity - Rat C, I 43632201, 05014915 870.4300 83 - 5 Com bined Chronic Toxicity/Carcinogenicity: Rats C, I 43755301 870.5100 84 -2 Bacterial Reverse Mutation Test C, I 41960801 870.5300 84 -2 Mutagenic

–Lymphoma Mutation

– Mouse C, I 41960803 870.5375 84 -2 Cy togenetis

– CHO Chromosomal Aberrations C, I 41960802 870.5395 84 -2 Unscheduled DNA Synthesis - Rat C, I 41960804 870.7800 85 - 7 Immunotoxicity C, I Study called in via the DCI, however EPA granted a waiver request in May 2011. Non- guideline study Nonguideline study Acute Inhalation (human study) C, I 46443801 Non- guideline study Nonguideline study BMC concentration analysis C, I 46614801 Non- guideline study Nonguideline study Quantification of the

chemosensations produced from chloropicrin vapors C, I 451178901 **ENVIRONMENTAL FATE** 835.1240 163 - 1 Leaching/Adsorption/Desorption C, I 44191301 835.1410 163 - 2 Laboratory Volatilization (from Soil) Study C, I 43798601 835.2120 161 - 1 Hydrolysis C, I 43022401 835.2240 161 - 2 Photodegradation - Water C, I 42900201 835.2370 161 -4 Photolysis Air C, I 05007865 835.4100 162 - 1 Aerobic Soil Metabolism C, I 43613901 835.4400 162 - 3 Anaerobic Aquatic Metabolism C, I 43759301 835.6100 164 - 1 Terrestrial Field Dissipation C, I 43085101

835.8100 163 - 3 Field Volatility (from soil) Study C, I 44149201, 47576901, 47295202, 47295203, 47295204, 45112902, 46420201, 45112901, 47456001 , 47679301, 48033801, 48011601, 47820001, 47813801, 48006001, 48107601, 47813901, 47456001, 48087401 , 47576901 **OCCUPATIONAL AND RESIDENTIAL EXPOSURE** 875.1300 232 Inhalation Exposure C 44149201, 45112901 (data gap for EFED) 875.2500 133 -4 Inhalation (Passive Dosimetry) Exposure C 44149201, 45112901 **OTHER -** **No Category**  Special Study NA Fumigant Buffer Zone Posting C, I Data gap satisfied May**Data Requirement Use Patterns**  **Citations**

**New Guideline**  **Number Old** 

**Guideline Number**  **Description**

Signs 2011 Special Study NA Community Outreach and Education Program C, I Data gap Special Study NA Certified Applicator Training C, I Data gap Special Study NA Safe Handler Information C, I Data gap satisfied 2010