Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 425997 :



### Page 1 of 22 **UNITED STA**

**TES ENVIRONMENTA L PROTECTION A**  **GENCY** WA SHINGTON, D.C. 20460 **Office of Chem ical Safety and Pollution Prevention**  

### MEMORANDUM July 1 , 20 1 5 **SUBJECT: Cyprodinil** 

**–** Acute and Chronic Dietary and Drinking Water Exposure and Risk

Assessm ent For The Expansions of Existing Crop Group/Representative Commodity

Uses to Stone Fruit Group 12 - 12, and Adding New Uses on the Artichoke, Guava, Pomegranate, Passionfruit, Feijoa, Jaboticaba, Wax Jambu, Starf r uit, and Acerola and Amended Uses on Greenh ouse Cucumbers and Small Tomatoes. **PC Code:** 288202 **DP Barcode:** D425997 **Decision No** .: 490951 **Registration No. :**  100 - 811, 100 - 1317, 100 - 828, & 100 - 953 **Petition No.:** 4e8273 **Regulatory Action:** Section 3 **Risk Assessment Type:** Dietary **Case No.:** NA **T XR No.:**  NA **CAS No :**  121552 - 61 - 2 **MRID No.:** NA **40 CFR:** 180.532 

### FROM: Thurston G. Morton, Chemist

Risk Assessment Branch I V Health Effects Division (7509 P ) **THROUGH:** Pete Savoia , Chemist

Meheret Negussie, Chemist Dietary Exposure Science Advisory Co uncil (DESAC), and Charles Smith , Acting Branch Chief Health Effects Division (7509 P ) **TO:** Laura Nollen/Barbara Madden

Risk I ntegration, Minor Use & Emergency Response Branch Registration Division (RD) (7505P)Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 425997 :



### Page 2 of 22 This document provi des an acute and chronic dietary and drinking water risk analy ses of exposures resulting from use of cy prodinil as a fungicide on food crops . This assessment supports requests f

or t he e xpansion of e xisting c rop g roup fruit, stone, group 12 - 12, and a dding n ew u ses on the globe artichoke, g uava, p omegranate, p assionfruit, f eijoa, j aboticaba, w ax j ambu, s tarf

r uit, and a cerola and amended u ses on g reenhouse c ucumbers and s mall t omatoes. **Executive Summary** Acute and chronic dietary risk assessments w ere conduc ted for cy prodinil using the Dietary Exposure Evaluation Model ( DEEM - FCI D, Version 3.18 ), which incorporates consumption data from USDA’s National Health and Nutrition Examination Survey , What We Eat in America, (NHANES/WWEI A). This dietary survey was con ducted from 2003 to 20 08 . Acute Dietary

Exposure Analy sis Results and Characterization A conservative acute dietary exposure analy sis was performed for the general U.S. population and various population subgroups. T olerance level residues and 100 % c rop treated assumptions were used. DEEM default and empirical processing factors were used to modify the tolerance values. The acute analy sis incorporated the 1 in 10 y ear peak surface drinking water estimate f rom application of cy

prodinil to grapes . The resulting 9 5 th percentile acute exposure estimate s are not of concern for the general U.S. population or any of the other population subgroups. The subgroup with the highest risk estimate i s children 1 - 2 y ears old with a % acute po pulation adjusted dose ( a PAD ) of 8.6 %. The % a PAD for the general U.S. population i s 4. 8 %. Chronic Dietary

Exposure Analy sis Results and Characterization A partially refined chronic dietary exposure analy sis was performed for the general U.S. popul ation and various population subgroups. For the chronic dietary analy sis, tolerance level residues for most commodities; average field trial residues for pome fruit, head lettuce, leaf lettuce, spinach, tomato, and grapes; and 100% crop treated assumption s were used. DEEM default and empirical processing factors were used to modify the tolerance values. The chronic analy sis incorporated the 10 y ear average surface drinking water estimate from application of cy prodinil to grapes . Chronic dietary risk est imates are not of concern for the general U.S. population or any

of the other population subgroups. The subgroup with the highest risk estimate i s children 1 - 2 y ears old with a % chronic PAD ( cPAD ) of 85 %. The % cPAD for the general U.S. population i s 2 9 %. **I. Introduction**  Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects).Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 425997 :



### Page 3 of 22 This dose is referred to as the PAD. The PAD is equivalent to the point of departure (POD, NOAEL, LOAEL, etc) divided by the required uncertainty

or safety factors . For acute and non - cancer chronic expo sures, HED is concerned when estimated dietary risk exceeds 100 % of the PAD. References that discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pes ticides, A User’s Guide,” 6/21/2000, web link: http://www.epa.gov/fedrgstr/EPA_PEST/2000/July /Day _12/6061.pdf ; or see SOP 99.6 (8/20/99). The most recent dietary

risk asses sment for cy

prodinil was conducted by T. Morton ( 3 - May 201 2 ; DP# 390233 ). **II. Residue Information**  Residues of Concern The metabolism of cy

prodinil has been studied in apple, peach, potato, tomato, and wheat. The residue of concern in plants is the pare nt compound cy prodinil as determined by the HED Metabolism Assessment Review Committee (MARC) (D243198, G. Kramer, 3/11/98). The nature of the residue in ruminants is adequately understood based on acceptable lactating goat metabolism studies. HED has co ncluded that the residues of concern for both risk assessment and the tolerance definition should include the combined residues of cy prodinil and free and conjugated CGA - 304075, expressed in parent equivalents (D345970 and D345182, G. Kramer, 6/4/08). The water residue s of concern as determined by MARC are the parent and CGA 249287 (4 - cy clopropyl - 6 - methylpy rimidin - 2 - amine) (D292557, 6/8/03). HED continues to consider these metabolites and degradates to be the residues of concern. **Table 1**  **: Summ**  **ary of R**  **esidues of Concern for**  **Cyprodini l**  **Matrix Residues of Concern**  **For Risk Assessm ent**  **For Tolerance Expression** Plants cyprodinil cyprodinil Livestock cyprodinil and CGA - 304075 cyprodinil and CGA - 304075 Water cyprodinil and CGA 249287 NA 

### Established/Rec ommended Tolerances Permanent tolerances are established (40 CFR §180.532(a)) for residues of cy prodinil per se in/on a variety

of crop commodities, at levels ranging from 0.02 ppm in/on almonds to 340 ppm in citrus oil. Recommended tolerances for the pr oposed amended /new u se s are as follows ( D 421157 , T . Morton , 04 / 2 3 / 201 5 ) .Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 425997 :



### Page 4 of 22 Artichoke..... ................................ ................................ ............................... 4.0 ppm Guava ................................ ................................ ................................ ........... 1.5 ppm Passionfruit............................................. ............... ................1.5 ppm Feijoa................................................ ............... ....................1.5 ppm Jaboticaba......................................... ............... ......................1.5 ppm Wax Jambu......................................... ............... ....................1.5 ppm Starfruit ................................ ................................ ................................ ....... 1.5 ppm Acerola ................................ ................................ ................................ ......... 1.5 ppm Pom egranate ................................ ................................ ................................ 7.0 ppm Fruit, stone, group 12 - 12.................. ................................ ....................... 2.0 ppm 

### HED continues to recommend that the current tolerance expression for animal commodities be changed to reflect both p arent and metabolite CGA - 304075 ( 4 - [(4 - cy clopropyl - 6 - methyl - 2 - 2 - py rimidinyl)amino] - phenol ). Residues U sed in the Acute and Chronic Analy sis For the acute dietary

analy sis, tolerance level residues and 100% crop treated assumptions were used for all treat ed commodities . For the chronic dietary analy sis, tolerance level residues for most commodities; average field trial residues for pome fruit, head lettuce, leaf lettuce, spinach, tomato, and grapes; and 100% crop treated assumptions were used. Default pr ocessing factors were used for most processed commodities , except for tomato paste /puree in the chronic( 1x ) and lemon/lime juice (1x) . R esidues used in the acute and chronic dietary analy s i s are provided in Table 2 . Average residues where noted were used in the chronic dietary analy sis.
**Table 2. Residue Estim**  **ates Used in the Cyprodinil**  **Acute and Chronic Dietary**  **/ Drinking Water Analys**  **i s**  **Com mo**  **dity Tolerance (ppm**  **)** Crop Subgroup 1B , except sugarbeet 0.75 Crop Group 2 10 Onion , bulb subgroup 3 - 07A 0.6 O nion, green subgroup 3 - 07B 4.0 Crop Subgroup 4A 5 0 tolerance/0.87 avg head lettuce 50 tolerance/13 avg leaf lettuce 50 tolerance/11.8 avg spinach Crop Subgroup 4 B 30 Crop Subgroup 5A Head and stem 1.0 Crop Subgroup 5B Leafy Brassica greens 10 Bean, dry; Bean, succulent 0.6 Vegetable, fruiting, group 8 - 10 1. 5 Crop Group 9 0.7 Lemon, Lime 0.6 Citrus Oil 60 Pom e fruit , Crop group 11 - 10 (B. Cropp - Kohlligian, D378920, 10/27/10) 1.7 tolerance/0.50 avg apple 1.7 tolerance/0.38 avg pear Stone fruit , C rop group 12 2Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 425997 :



### Page 5 of 22 **Table 2. Residue Estim**  **ates Used in the Cyprodinil**  **Acute and Chronic Dietary**  **/ Drinking Water Analys**  **i s**  **Com mo**  **dity Tolerance (ppm**  **)** Caneberry , s ubgroup 13 - 07A 10 Bushberry s ubgroup 13 - 07 B 3 Small fruit vine climbing subgroup 13 - 07F, except fuzzy kiwifruit (G. Kramer, D247620, 6/14/02) 3 .0 tolerance/0.81 avg grapes Low growing berry subgroup 13 - 07G, except cranberry 5 .0 (inc. straw berry) Almond 0.02 Pistachio 0.1 Crop Subgroup 19A Herb Fresh (except parsley) 3 Crop Subgroup 19A Herb Dried (except parsley) 15 Parsley, dried leaves 170 Parsley leaves 35 Rape seed oil (cano la, seed) 0.03 Avocado, Canistel ; Mango ; Papaya ; Sapodilla ; Sapote, black; Sapote, mamey; Star apple 1.2 Dragonfruit 2.0 Kiwifruit 1.8 Watercress 20 Beef, Goat, Horse, Sheep, meat byproducts (including liver and kidney ) 0.02 Grape, raisin 5 .0 Turn ip, greens 10.0 

### III. **Percent Crop Treated Information** The acute and chronic dietary exposure analy ses assumed 100% crop treated (CT). **I V**  **. Drinking Water Data**  Drinking water residues were incorporated directly into the acute and chronic dietary analy s e s as “water, direct, all sources” and “water, indirect, all sources” and were provided by the Environmental Fate and Effects Division ( EFED ) (D 421158 , J Melendez 1 / 12 / 1 5 ). The tier 2 aquatic models PRZM (Pesticide Root Zone Model) - EXAMS (Exposure Analy s is Modeling Sy stem) , and the models Screening Concentration in Ground Water ( SCI - GROW ) and Pesticide Root Zone Model for Groundwater ( PRZM - GW ) w ere used to obtain estimated drinking water concentrations ( EDWCs ) in surface water and groundwater, respectivel y. The acute ED WC in surface water is 34.8 μg/L for the total residues of cy prodinil plus CGA - 249287. The chronic EDWC in surface waters is 24.7 μg/L for the total residues of cy prodinil and CGA - 249287. The cancer/chronic EDWC in surface waters is 16.4 μg/L for the tot al residues of cy prodinil and CGA - 249287. All surface waters EDWCs were obtained using the New York grapes PRZM scenario. The PRZM - GW generated EDWC for the use on grapes, using the FL citrus surrogate scenario were 2.05 μg/L for the total residues of cy prodinil and CGA - 249287 (acute) and 1.80 μg/L for the total residues (chronic). For details on methods, characterization of results, uncertainties, etc., please, refer to the previous DWAs. Table 3 provides a summary of the Tier 2 modeled drinking water c oncentrations.Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 425997 :



### Page 6 of 22 **Table 3**  **. M**  **axim um**  **Estim ated**  **Drinking Water**  **Concentrations for**  **the Use**  **of Cyprodinil**  **(expressed as**  **total residues of cyprodinil plus its degradate CGA**  **- 249287)**  **DRINKING WATER SOURCE (MODEL USED)**  **USE (rate modeled per year**  **) MAXIMUM ESTIMATED**  **DRINKING WATER CONCENTRATION (EDWC) (**  **ppb )**  Groundw ater ( PRZM - GW ) FL citrus 1 (1.4 lb a.i.) Acute 2.05 Chronic 1.80 Surface water (PRZM/ EXAMS) NY grapes (1.4 lb a.i.) Acute **34.8** Chronic **24.7** Cancer/Chronic 16.4 1 Scenario wa s used as a surroga te and run with the maximum application rate for grapes. 

### V. **DEEM -**  **FCID Program and Consumption Information** Cy prodinil acute and chronic dietary exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity In take Database DEEM - FCI D, Version 3.18 , which incorporates consumption data from USDA’s National Health and Nutrition Examination Survey , What We Eat in America, (NHANES/WWEIA). This dietary survey was conducted from 2003 to 20 08 . The data are based o n the reported consumption of more than 20,000 individuals over two non - consecutive survey day s. Foods “as consumed” (e.g., apple pie) are linked to EPA - defined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - co oked; fresh or N/S, baked) using publicly available recipe translation files developed jointly

by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acut e exposure assessment are retained as individual consumption events. Based on analy sis of the 2003 - 2008 WWEI A consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 y ear old), children 1 - 2, children 3 - 5, children 6 - 12, y outh 13 - 19, adults 20 - 49, females 13 - 49, and adults 50 - 99 y ears old. For chronic dietary

exposure assessment, an estimat e of the residue level in each food or food form ( e .g. , orange or orange juice) on the food commodity residue list is multiplied by the average daily

consumption estimate for that food/food form. The resulting residue consumption estimate for each food/fo od form is summed with the residue consumption estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day

and as a percent of the cPAD. This proc edure is performed for each population subgroup. For acute exposure assessments, individual one - day food consumption data are used on an individual - by - individual basis. The reported consumption amounts of each food item can be multiplied by

a residue poi nt estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user ( i.e. , those who reported eating relevantCyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 425997 :



### Page 7 of 22 commodities/food forms) and a per - capita ( i.e. , those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HE D policy , per capita exposure and risk are reported for all tiers of analy sis. However, for Tiers 1 and 2, significant differences in user vs. per capita exposure and risk are identified and noted in the risk assessment. **VI. Toxicological Information**  HE D evaluated the toxicology data base for cy

prodinil and selected doses and endpoints for chronic dietary and drinking water risk assessments provided in Table 4 . **Table 4. Sum ma**  **ry of Toxicological Doses and Endpoints for Cyprodinil for Use in Dietary Hum**  **an Health Risk Assessm ents**  **Exposure/Scenario Point of**  **Departure Uncertainty/F** 

**QPA Safety Factors**  **RfD, PAD, LOC**

**for Risk Assessment**  **Study and Toxicological Effects** Acute Dietary (All Populations) NOAEL = 20 0 mg/kg/day UF A = 10x

UF H =10x FQPA SF= 1x Acute RfD = 2.0

mg/kg/day aPAD = 2.0 mg/kg/day Acute Neurotoxicity - Rat

LOAEL = 600 mg/kg/day based on clinical signs of toxicity, low motor activity and reversible hypothermia Chronic Dietary (All Populations) NOAEL= 2.7 mg/kg/day UF A = 10x

UF H =10x FQPA SF= 1x Chronic RfD =

0.0 27 mg/kg/day cPAD = 0.0 27 mg/kg/day 2 - Year Chronic Toxicity/ Carcinogenicity - rat

LOAEL = 35.6 mg/kg/day based on degenerative liver lesions (spongiosis hepatis) in males. Cancer (all routes) Classification: “Not l ikely to be carcinogenic to humans”

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose - response data and used to mark the beginning of extrapolation to determine risk associated with lower environmentally rel evant human exposures. NOAEL = no observed adverse effect level. LO AEL = lowest observed adverse effect level. UF = uncertainty factor. UF A = extrapolation from animal to human (interspecies). UF H = potential variation in sensitivity among member s of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD = reference dose. 

### VII. **Results/Discussion** As stated above, for acute and chronic assessments, HED is concerned wh en dietary risk exceeds 100% of the PAD. The DEEM - FCI DTM analy ses estimate the dietary exposure of the U.S. population and various population subgroups. The results reported in Table s 5 & 6 are for the general U.S. Population, all infants (<1 y ear old), c hildren 1 - 2, children 3 - 5, children 6 - 12, y outh 13 - 19, females 13 - 49, adults 20 - 49, and adults 50 - 99 ye ars.Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 425997 :



### Page 8 of 22 Results of Acute Dietary

Exposure Analy sis The results of the acute dietary exposure analy sis are reported in Table 5. **Table 5**  **: Sum ma**  **ry of Acute Dietary Exposure and Risk for**  **Cyprodinil Population Subgroup**  **a PAD (m**  **g/kg/day) Acute (9**  **5 th Percentile)**  **Exposure (m g/kg/day)**  **%aPAD** General U.S. Population

2.0 0.0 9 5198 4. 8 All Infants (< 1 year old) 0. 101588 5.1 **Children 1 -**  **2 years old 0.**  **172629 8**  **.6** Children 3 - 5 years old 0. 158663 7.9 Children 6 - 12 years old 0.0 83374 4. 2 Youth 13 - 19 years old 0.0 71 553 3.6 Adults 20 - 49 years old 0.0 9 1866 4. 6 Adults 50+ years old 0.0 9 1595 4 . 6 Females 13 - 49 years old 0.0 9 6706 4.8 The bolded % a PA D is the highest. 

### Results of Chronic Dietary Exposure Analy sis The results of the chronic dietary exposure analy sis are reported in T able 6 . **Table 6**  **: Sum ma**  **ry of Chronic Dietary Exposure and Risk for Cyprodinil**  **Population Subgroup cPAD (m**  **g/kg/day) Chronic**  **Exposure (m g/kg/day)**  **% cPAD**  General U.S. Population

0.0 27 0.0 0 7794 2 9 All Infants (< 1 year old) 0.0 1 3042 4 8 **Children 1 -**  **2 years old 0.**  **0 2**  **3 045**  **85** Children 3 - 5 years old 0.0 1 6592 62 Children 6 - 12 years old 0.0 08 522 32 Youth 13 - 19 years old 0.0 0 4 6 65 1 7 Adults 20 - 49 years old 0.0 0 6 327 2 3 Adults 50+ years old 0.0 0 7 772 2 9 Females 13 - 49 years old 0.0 0 6 706 2 5 The bolded %cPAD is the highest. 

### VIII. **Characterization of Inputs/Outputs** For the acute dietary

analy sis, tolerance level residues and 10 0% crop treated assumptions were used for all treated commodities . For the chronic dietary analy sis, tolerance level residues for most commodities ; average field trial residues for pome fruit, head lettuce, leaf lettuce, spinach, tomatoes, lemon, and grap es; and 100% crop treated assumptions were used. Default processing factors were used for all processed commodities except tomato paste /puree ( 1 x) and lemon/lime juice (1x). Risk drivers are celery , pome fruit, and strawberry . Residues do not warrant further refinement at this time.Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 425997 :



### Page 9 of 22 **IX. Conclusions**  An acute and chronic dietary exposure analy ses was performed for the general U.S. population and various population subgroups . The acute and chronic risk estimates are below HED’s level of concern. HED is confid ent the acute and chronic dietary exposures to cy

prodinil are not underestimated. **X. List of Attachments** 1. Acute DEEM - FCI D Residue I nput File. 2. Results of Acute DEEM - FCI D Dietary Exposure Analy sis. 3. Chronic DEEM - FCI D Residue I nput File. 4 . Results of Chronic DEEM - FCI D Dietary Exposure Analy sis.Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 425997 :



### Page 10 of 22 Attachment 1 Acute DEEM - FCI D Residue I nput File Filename: C: \ Users \ tmorton \ Documents \ My Files \ DEEM Files \ 288202 Cyprodinil \ Cyprodinil 4E8273 \ 288202ACUTEEPARECOMMENDATIONS PLUS 13 - 07F CODEX HARM.R 08 Chemical: cyprodinil RfD(Chronic): .03 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): 2 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Date created/last modified: 04
- 09 - 2015/09:37:24 Program ver. 3.16, 03
- 08 - d

-------------------------------- --------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ----------------------------- -- ---------- ------ ------ ------- 0101050000 1AB Beet, garden, roots 0.750000 1.000 1.000 0101050001 1AB Beet, garden, roots - babyfood 0.750000 1.000 1.000 0101067000 1AB Burdock 0.750000 1 .000 1.000 0101078000 1AB Carrot 0.750000 1.000 1.000 0101078001 1AB Carrot - babyfood 0.750000 1.000 1.000 0101079000 1AB Carrot, juice 0.750000 1.000 1.000 0101084000 1AB Celeriac 0.750000 1.000 1.000 0101100000 1AB Chicory, roots 0.750000 1.000 1.000 0101168000 1AB Ginseng, dried 0.750000 1.000 1.000 0101190000 1AB Horseradish 0.750000 1.000 1.000 0101250000 1AB Parsley, turnip rooted 0.750000 1.000 1.000 0101251000 1AB Parsnip 0.750000 1.000 1.000 0101251001 1AB Parsnip - babyfood 0.750000 1.000 1.000 0101314000 1AB Radish, roots 0.750000 1.000 1.000 0101316000 1AB Radish, Oriental, roots 0.750000 1.000 1.000 0101327000 1AB Rutabaga 0.750000 1.000 1.000 010133100 0 1AB Salsify, roots 0.750000 1.000 1.000 0101388000 1AB Turnip, roots 0.750000 1.000 1.000 0200051000 2 Beet, garden, tops 10.000000 1.000 1.000 0200101000 2 Chicory, tops 10.000000 1.000 1.000 0200140000 2 Dasheen, leaves 10.000000 1.000 1.000 0200315000 2 Radish, tops 10.000000 1.000 1.000 0200317000 2 Radish, Oriental, tops 10.000000 1.000 1.000 0200332000 2 Salsify, tops 10.000000 1.000 1.000 0301165000 3A Garlic, bulb 0.600000 1.000 1.000 0301165001 3A Garlic, bulb - babyfood 0.600000 1.000 1.000 0301237 000 3A Onion, bulb 0.600000 1.000 1.000 0301237001 3A Onion, bulb - babyfood 0.600000 1.000 1.000 0301238000 3A Onion, bulb, dried 0.600000 9.000 1.000 0301238001 3A Onion, bulb, dri ed - babyfood 0.600000 9.000 1.000 0301338000 3A Shallot, bulb 0.600000 1.000 1.000 0302103000 3B Chive, fresh leaves 3.000000 1.000 1.000 0302198000 3B Leek 4.0000 00 1.000 1.000 0302239000 3B Onion, green 4.000000 1.000 1.000 0302338500 3B Shallot, fresh leaves 4.000000 1.000 1.000 0401005000 4A Amaranth, leafy 50.000000 1.000 1.000 04010 18000 4A Arugula 50.000000 1.000 1.000 0401104000 4A Chrysanthemum, garland 50.000000 1.000 1.000 0401133000 4A Cress, garden 50.000000 1.000 1.000 0401134000 4A Cress, upland 50.000000 1.000 1.000 0401138000 4A Dandelion, leaves 50.000000 1.000 1.000 0401150000 4A Endive 50.000000 1.000 1.000 0401204000 4A Lettuce, head 50.00 0000 1.000 1.000 0401205000 4A Lettuce, leaf 50.000000 1.000 1.000 0401248000 4A Parsley, leaves 50.000000 1.000 1.000 0401313000 4A Radicchio 50.000000 1.000 1.000 040 1355000 4A Spinach 50.000000 1.000 1.000 0401355001 4A Spinach - babyfood 50.000000 1.000 1.000 0402076000 4B Cardoon 30.000000 1.000 1.000 0402085000 4B Celery 30.000000 1.000 1.000 0402085001 4B Celery - babyfood 30.000000 1.000 1.000 0402086000 4B Celery, juice 30.000000 1.000 1.000 0402087000 4B Celtuce 30. 000000 1.000 1.000 0402152000 4B Fennel, Florence 30.000000 1.000 1.000 0402322000 4B Rhubarb 30.000000 1.000 1.000 0402367000 4B Swiss chard 30.000000 1.000 1.000 0 501061000 5A Broccoli 1.000000 1.000 1.000Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 425997 :



### Page 11 of 22 0501061001 5A Broccoli - babyfood 1.000000 1.000 1.000 0501062000 5A Broccoli, Chinese 1.000000 1.000 1.000 0501064000 5A Brussels s prouts 1.000000 1.000 1.000 0501069000 5A Cabbage 1.000000 1.000 1.000 0501071000 5A Cabbage, Chinese, napa 1.000000 1.000 1.000 0501072000 5A Cabbage, Chinese, mustard 1.000000 1.000 1.000 0501083000 5A Cauliflower 1.000000 1.000 1.000 0501196000 5A Kohlrabi 1.000000 1.000 1.000 0502063000 5B Broccoli raab 10.000000 1.000 1.000 0502070000 5B Cabbage, Chinese, bok choy 10.000000 1.000 1.000 0502117000 5B Collards 10.000000 1.000 1.000 0502194000 5B Kale 10.000000 1.000 1.000 0502229000 5B Mustard greens 10.000000 1.000 1.000 0502318000 5B Rape greens 10.000000 1.000 1.000 0502389000 5B Turnip, greens 10.000000 1.000 1.000 0602031000 6B Bean, broad, succulent 0.600000 1.000 1.000 0602033000 6B Bean, cowpea, succulent 0.600000 1.000 1.000 0602037000 6B Bean, lima, succulent 0.600000 1.000 1.000 0603030000 6C Bean, black, seed 0.600000 1.000 1.000 0603032000 6C Bean, broad, seed 0.600000 1.000 1.000 0603034000 6C Bean, cowpea, seed 0.600000 1.000 1.000 0603035000 6C Bean, great northern, seed 0.600000 1.000 1.000 0603036000 6C Bean, kidney, seed 0.600000 1.000 1.000 0603038000 6C Bean, lima, seed 0.600000 1.000 1.000 0603039000 6C Bean, mung, seed 0.600000 1.000 1.000 0603040000 6C Bean, navy, seed 0.600000 1.000 1.000 0603041000 6C Bean, pink, seed 0.600000 1.000 1.000 0603042000 6C Bean, pinto, seed 0.600000 1.000 1.000 0603098000 6C Chickpea, seed 0.600000 1.000 1.0 00 0603098001 6C Chickpea, seed - babyfood 0.600000 1.000 1.000 0603099000 6C Chickpea, flour 0.600000 1.000 1.000 0603182000 6C Guar, seed 0.600000 1.000 1.000 0603182001 6C Guar , seed - babyfood 0.600000 1.000 1.000 0603203000 6C Lentil, seed 0.600000 1.000 1.000 0801374000 8A Tomatillo 1.500000 1.000 1.000 0801375000 8A Tomato 1.500000 1.000 1.000 0801375001 8A Tomato - babyfood 1.500000 1.000 1.000 0801376000 8A Tomato, paste 1.500000 1.000 1.000 0801376001 8A Tomato, paste - babyfood 1.500000 1.000 1 .000 0801377000 8A Tomato, puree 1.500000 1.000 1.000 0801377001 8A Tomato, puree - babyfood 1.500000 1.000 1.000 0801378000 8A Tomato, dried 1.500000 14.300 1.000 0801378001 8A To mato, dried - babyfood 1.500000 14.300 1.000 0801379000 8A Tomato, juice 1.500000 1.000 1.000 0801380000 8A Tomato, Tree 1.500000 1.000 1.000 0802148000 8BC Eggplant 1.500000 1.000 1.000 0802234000 8BC Okra 1.500000 1.000 1.000 0802270000 8B Pepper, bell 1.500000 1.000 1.000 0802270001 8B Pepper, bell - babyfood 1.500000 1.000 1.000 0802271000 8B Pepper, bell, dried 1.500000 1.000 1.000 0802271001 8B Pepper, bell, dried - babyfood 1.500000 1.000 1.000 0802272000 8BC Pepper, nonbell 1.500000 1.000 1.000 0802272001 8BC Pepper, nonbell - babyfood 1.500000 1.000 1.000 0802273000 8BC Pepper, nonbell, dried 1.500000 1.000 1.000 0901075000 9A Cantaloupe 0.700000 1.000 1.000 0901187000 9A Honeydew melon 0.700000 1.000 1.000 0901399000 9A Watermelon 0.700000 1.000 1.000 0901400000 9A Watermelon, juice 0.700000 1.000 1.000 0902021000 9B Balsam pear 0.700000 1.00 0 1.000 0902088000 9B Chayote, fruit 0.700000 1.000 1.000 0902102000 9B Chinese waxgourd 0.700000 1.000 1.000 0902135000 9B Cucumber 0.700000 1.000 1.000 0902308000 9B Pumpkin 0.700000 1.000 1.000 0902309000 9B Pumpkin, seed 0.700000 1.000 1.000 0902356000 9B Squash, summer 0.700000 1.000 1.000 0902356001 9B Squash, summer - babyfood 0.700000 1.000 1.000 0902357000 9B Squash, winter 0.700000 1.000 1.000 0902357001 9B Squash, winter - babyfood 0.700000 1.000 1.000 1001108000 10A Citrus, oil 60.000000 1. 000 1.000 1002199000 10B Lemon 0.600000 1.000 1.000Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 425997 :



### Page 12 of 22 1002200000 10B Lemon, juice 0.600000 1.000 1.000 1002200001 10B Lemon, juice - babyfood 0.600000 1.000 1.000 1002201000 1 0B Lemon, peel 0.600000 1.000 1.000 1002206000 10B Lime 0.600000 1.000 1.000 1002207000 10B Lime, juice 0.600000 1.000 1.000 1002207001 10B Lime, juice - babyfood 0.600000 1.000 1.000 1100007000 11 Apple, fruit with peel 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 1100008000 11 Apple, peeled fruit 1.700000 1.000 1.000 PP#0F7

Fu ll comment: PP#0F7696 1100008001 11 Apple, peeled fruit - babyfood 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 1100009000 11 Apple, dried 1.700000 8.000 1.000 PP#0F7

Full comment: PP#0F7 696 1100009001 11 Apple, dried - babyfood 1.700000 8.000 1.000 PP#0F7

Full comment: PP#0F7696 1100010000 11 Apple, juice 1.700000 1.300 1.000 PP#0F7

Full comment: PP#0F7696 1100010001 11 Apple, juice - babyfood 1.700000 1.300 1.000 PP#0F7

Full comment: PP#0F7696 1100011000 11 Apple, sauce 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 1100011001 11 Apple, sauce - bab yfood 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 1100129000 11 Crabapple 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 1100173500 11 Goji berry 1.500000 1.000 1.000 1100210000 11 Loquat 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 1100266000 11 Pear 1.700000 1.000 1.000 PP#0F7

Full comment: P P#0F7696 1100266001 11 Pear - babyfood 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 1100267000 11 Pear, dried 1.700000 6.250 1.000 PP#0F7

Full comment: PP#0F7696 110026800 0 11 Pear, juice 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 1100268001 11 Pear, juice - babyfood 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 1100310000 11 Quince 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 1201090000 12A Cherry 2.000000 1.000 1.000 1201090001 12A Cherry - babyfood 2.000000 1.000 1.000 1201091000 12A Cherry, juice 2.000000 1.500 1.000 1201091001 12A Cherry, juice - babyfood 2.000000 1.500 1.000 1202012000 12B Apricot 2.000000 1.000 1.000 1202012001 12B Apricot - babyfood 2.000000 1.000 1.000 1202013000 12B Apricot, dried 2.000000 6.000 1.000 1202014000 12B Apricot, juice 2.000000 1.000 1.000 1202014001 12B Apricot, juice - babyfood 2.000000 1.000 1.000 1202230000 12B Nectarine 2.000000 1.000 1.000 1202260000 12B Peach 2.000000 1.000 1.000 1202260001 12B Peach - babyfood 2.000000 1.000 1.000 12022610 00 12B Peach, dried 2.000000 7.000 1.000 1202261001 12B Peach, dried - babyfood 2.000000 7.000 1.000 1202262000 12B Peach, juice 2.000000 1.000 1.000 1202262001 12B Peach, juice - baby food 2.000000 1.000 1.000 1203285000 12C Plum 2.000000 1.000 1.000 1203285001 12C Plum - babyfood 2.000000 1.000 1.000 1203286000 12C Plum, prune, fresh 2.00000 0 1.000 1.000 1203286001 12C Plum, prune, fresh - babyfood 2.000000 1.000 1.000 1203287000 12C Plum, prune, dried 2.000000 5.000 1.000 1203287001 12C Plum, prune, dried - babyfood 2.000000 5.000 1.000 120328 8000 12C Plum, prune, juice 2.000000 1.400 1.000 1203288001 12C Plum, prune, juice - babyfood 2.000000 1.400 1.000 1301055000 13A Blackberry 10.000000 1.000 1.000 1301056000 13A Blackberry, jui ce 10.000000 1.000 1.000 1301056001 13A Blackberry, juice - babyfood 10.000000 1.000 1.000 1301058000 13A Boysenberry 10.000000 1.000 1.000 1301208000 13A Loganberry 10.000 000 1.000 1.000Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 425997 :



### Page 13 of 22 1301320000 13A Raspberry 10.000000 1.000 1.000 1301320001 13A Raspberry - babyfood 10.000000 1.000 1.000 1301321000 13A Raspberry, juice 10.000000 1.000 1.000 1301 321001 13A Raspberry, juice - babyfood 10.000000 1.000 1.000 1302057000 13B Blueberry 3.000000 1.000 1.000 1302057001 13B Blueberry - babyfood 3.000000 1.000 1.000 1302136000 13B Currant 3.000000 1.000 1.000 1302137000 13B Currant, dried 3.000000 1.000 1.000 1302149000 13B Elderberry 3.000000 1.000 1.000 1302174000 13B Gooseberry 3.0 00000 1.000 1.000 1302191000 13B Huckleberry 3.000000 1.000 1.000 1304175000 13D Grape 3.000000 1.000 1.000 1304176000 13D Grape, juice 3.000000 1.200 1.000 13 04176001 13D Grape, juice - babyfood 3.000000 1.200 1.000 1304179000 13D Grape, wine and sherry 3.000000 1.000 1.000 1304195000 13D Kiwifruit, fuzzy 1.800000 1.000 1.000 1307359000 13G Strawberry 5.000000 1.000 1.000 1307359001 13G Strawberry - babyfood 5.000000 1.000 1.000 1307360000 13G Strawberry, juice 5.000000 1.000 1.000 1307360001 13G Strawberry, juice - babyfood 5 .000000 1.000 1.000 1400003000 14 Almond 0.020000 1.000 1.000 1400003001 14 Almond - babyfood 0.020000 1.000 1.000 1400004000 14 Almond, oil 0.020000 1.000 1.000 1400004001 14 Almond, oil - babyfood 0.020000 1.000 1.000 1400282000 14 Pistachio 0.100000 1.000 1.000 1901028000 19A Basil, fresh leaves 3.000000 1.000 1.000 1901028001 19A Basil, fr esh leaves - babyfood 3.000000 1.000 1.000 1901029000 19A Basil, dried leaves 15.000000 1.000 1.000 1901029001 19A Basil, dried leaves - babyfood 15.000000 1.000 1.000 1901102500 19A Chive, dried leaves 15.000000 1.000 1.000 1901118000 19A Cilantro, leaves 3.000000 1.000 1.000 1901118001 19A Cilantro, leaves - babyfood 3.000000 1.000 1.000 1901144000 19A Dillweed 3.000000 1.000 1.000 1901184000 19A Herbs, other 3.000000 1.000 1.000 1901184001 19A Herbs, other - babyfood 3.000000 1.000 1.000 1901202000 19A Lemongrass 3.000000 1.000 1.000 1901220000 19A Marjora m 3.000000 1.000 1.000 1901220001 19A Marjoram - babyfood 3.000000 1.000 1.000 1901249000 19A Parsley, dried leaves 170.000000 1.000 1.000 1901249001 19A Parsley, dried leaves - babyfood 170.000000 1.000 1.000 1901334000 19A Savory 3.000000 1.000 1.000 2001319000 20A Rapeseed, oil 0.030000 1.000 1.000 2001319001 20A Rapeseed, oil - babyfood 0.030000 1.000 1.00 0 3100046000 31 Beef, meat byproducts 0.020000 1.000 1.000 3100046001 31 Beef, meat byproducts - babyfood 0.020000 1.000 1.000 3100048000 31 Beef, kidney 0.020000 1.000 1.000 3100049000 31 Beef, liver 0.020000 1.000 1.000 3100049001 31 Beef, liver - babyfood 0.020000 1.000 1.000 3200170000 32 Goat, meat byproducts 0.020000 1.000 1.000 3200172000 32 Goat, kidney 0.020000 1.000 1.000 3200173000 32 Goat, liver 0.020000 1.000 1.000 3500340000 35 Sheep, meat byproducts 0.020000 1.000 1.000 3500342000 35 Sheep, kidney 0.020000 1.000 1. 000 3500343000 35 Sheep, liver 0.020000 1.000 1.000 8601000000 86A Water, direct, all sources 0.034790 1.000 1.000 8602000000 86B Water, indirect, all sources 0.034790 1.000 1.000 9500001000 O Ace rola 1.500000 1.000 1.000 9500016000 O Artichoke, globe 4.000000 1.000 1.000 9500020000 O Avocado 1.200000 1.000 1.000 9500074000 O Canistel 1.200000 1.000 1.000 9500151000 O Feijoa 1.500000 1.000 1.000 9500177000 O Grape, leaves 3.000000 1.000 1.000 9500178000 O Grape, raisin 5.000000 1.000 1.000 9500183000 O Guava 1.500000 1.000 1.000 9500183001 O Guava - babyfood 1.500000 1.000 1.000 9500209000 O Longan 2.000000 1.000 1.000 9500211000 O L ychee 2.000000 1.000 1.000 9500212000 O Lychee, dried 2.000000 1.850 1.000 9500215000 O Mango 1.200000 1.000 1.000 9500215001 O Mango - babyfood 1.200000 1.000 1.000Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 425997 :



### Page 14 of 22 9500216000 O Mango, dried 1.200000 1.000 1.000 9500217000 O Mango, juice 1.200000 1.000 1.000 9500217001 O Mango, juice - babyfood 1.200000 1.000 1.000 9500245000 O Papaya 1.200000 1.000 1.000 9500245001 O Papaya - babyfood 1.200000 1.000 1.000 9500246000 O Papaya, dried 1.200000 1.800 1.000 9500247000 O Papaya, juice 1.200000 1.500 1.000 9500252000 O Passionfruit 1.500000 1.000 1.000 9500252001 O Passionfruit - babyfood 1.500000 1.000 1.000 9500253000 O Passionfruit, juice 1.500000 1.000 1.000 9500253001 O Passionfruit, juice - babyfood 1.500000 1.000 1.000 9500289000 O Pomegranate 10.000000 1.000 1.000 9500333000 O Sapote, Mamey 1.200000 1.0 00 1.000 9500351000 O Spanish lime 2.000000 1.000 1.000 9500358000 O Starfruit 1.500000 1.000 1.000 9500398000 O Watercress 20.000000 1.000 1.000Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 425997 :



### Page 15 of 22 Attachment 2 Chronic DEEM - FCI D Residue I nput File Filename: C: \ Users \ tmorton \ Documents \ My Files \ DEEM Files \ 288202 Cyprodinil \ Cyprodinil 4E8273 \ 288202CHRONICEPARECOMMENDATIONS.R08 Chemical: cyprodinil RfD(Chronic): .03 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): 1.5 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Date created/last modified: 04
- 09 - 2015/09:10:28 Program ver. 3.16, 03
- 08 - d

-------------------------------------------------------------------- --------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ----- -- 0101050000 1AB Beet, garden, roots 0.750000 1.000 1.000 0101050001 1AB Beet, garden, roots - babyfood 0.750000 1.000 1.000 0101067000 1AB Burdock 0.750000 1.000 1.000 0101078000 1AB Carrot 0.750000 1.000 1.000 0101078001 1AB Carrot - babyfood 0.750000 1.000 1.000 0101079000 1AB Carrot, juice 0.750000 1.000 1.000 0101084000 1AB Celeriac 0.750000 1.000 1.000 0101100000 1AB Chicory, roots 0.750000 1.000 1.000 0101168000 1AB Ginseng, dried 0.750000 1.000 1.000 0101190000 1AB Horseradish 0.750000 1.000 1.0 00 0101250000 1AB Parsley, turnip rooted 0.750000 1.000 1.000 0101251000 1AB Parsnip 0.750000 1.000 1.000 0101251001 1AB Parsnip - babyfood 0.750000 1.000 1.000 0101314000 1AB Radi sh, roots 0.750000 1.000 1.000 0101316000 1AB Radish, Oriental, roots 0.750000 1.000 1.000 0101327000 1AB Rutabaga 0.750000 1.000 1.000 0101331000 1AB Salsify, roots 0.750000 1.000 1.000 0101388000 1AB Turnip, roots 0.750000 1.000 1.000 0200051000 2 Beet, garden, tops 10.000000 1.000 1.000 0200101000 2 Chicory, tops 10.000000 1.000 1 .000 0200140000 2 Dasheen, leaves 10.000000 1.000 1.000 0200315000 2 Radish, tops 10.000000 1.000 1.000 0200317000 2 Radish, Oriental, tops 10.000000 1.000 1.000 0200332000 2 Sa lsify, tops 10.000000 1.000 1.000 0301165000 3A Garlic, bulb 0.600000 1.000 1.000 0301165001 3A Garlic, bulb - babyfood 0.600000 1.000 1.000 0301237000 3A Onion, bulb 0.600000 1.000 1.000 0301237001 3A Onion, bulb - babyfood 0.600000 1.000 1.000 0301238000 3A Onion, bulb, dried 0.600000 9.000 1.000 0301238001 3A Onion, bulb, dried - babyfood 0.600000 9.000 1.000 0301338000 3A Shallot, bulb 0.600000 1.000 1.000 0302103000 3B Chive, fresh leaves 3.000000 1.000 1.000 0302198000 3B Leek 4.000000 1.000 1.000 0302239000 3B Onion, green 4.000000 1.000 1.000 0302338500 3B Shallot, fresh leaves 4.000000 1.000 1.000 0401005000 4A Amaranth, leafy 50.000000 1.000 1.000 0401018000 4A Arugula 50.000000 1.000 1.000 0401104000 4A Chrysanthemum, garland 50.000000 1.000 1.000 0401133000 4A Cress, garden 50.000000 1.000 1.000 0401134000 4A Cress, upland 50.000000 1.00 0 1.000 0401138000 4A Dandelion, leaves 50.000000 1.000 1.000 0401150000 4A Endive 50.000000 1.000 1.000 0401204000 4A Lettuce, head 0.870000 1.000 1.000 0401205000 4A Lettuce, leaf 13.000000 1.000 1.000 0401248000 4A Parsley, leaves 35.000000 1.000 1.000 0401313000 4A Radicchio 50.000000 1.000 1.000 0401355000 4A Spinach 11.800000 1.000 1.000 0401355001 4A Spinach - babyfood 11.800000 1.000 1.000 0402076000 4B Cardoon 30.000000 1.000 1.000 0402085000 4B Celery 30.000000 1. 000 1.000 0402085001 4B Celery - babyfood 30.000000 1.000 1.000 0402086000 4B Celery, juice 30.000000 1.000 1.000 0402087000 4B Celtuce 30.000000 1.000 1.000 0402152000 4 B Fennel, Florence 30.000000 1.000 1.000 0402322000 4B Rhubarb 30.000000 1.000 1.000 0402367000 4B Swiss chard 30.000000 1.000 1.000 0501061000 5A Broccoli 1.000000 1.000 1.000Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 425997 :



### Page 16 of 22 0501061001 5A Broccoli - babyfood 1.000000 1.000 1.000 0501062000 5A Broccoli, Chinese 1.000000 1.000 1.000 0501064000 5A Brussels sprouts 1.000000 1.000 1.000 0501069000 5A Cabbage 1.000000 1.000 1.000 0501071000 5A Cabbage, Chinese, napa 1.000000 1.000 1.000 0501072000 5A Cabbage, Chinese, mustard 1.000000 1.000 1.000 0501083000 5A Cauliflower 1.000000 1.000 1.000 0501196000 5A Kohlrabi 1.000000 1.000 1.000 0502063000 5B Broccoli raab 10.000000 1.000 1.000 0502070000 5B Cabbage, Chinese, b ok choy 10.000000 1.000 1.000 0502117000 5B Collards 10.000000 1.000 1.000 0502194000 5B Kale 10.000000 1.000 1.000 0502229000 5B Mustard greens 10.000000 1.000 1.000 0502318000 5B Rape greens 10.000000 1.000 1.000 0502389000 5B Turnip, greens 10.000000 1.000 1.000 0602031000 6B Bean, broad, succulent 0.600000 1.000 1.000 06020330 00 6B Bean, cowpea, succulent 0.600000 1.000 1.000 0602037000 6B Bean, lima, succulent 0.600000 1.000 1.000 0603030000 6C Bean, black, seed 0.600000 1.000 1.000 0603032000 6C Bean, broad, seed 0.600000 1.000 1.000 0603034000 6C Bean, cowpea, seed 0.600000 1.000 1.000 0603035000 6C Bean, great northern, seed 0.600000 1.000 1.000 0603036000 6C Bean, kidney, seed 0.60000 0 1.000 1.000 0603038000 6C Bean, lima, seed 0.600000 1.000 1.000 0603039000 6C Bean, mung, seed 0.600000 1.000 1.000 0603040000 6C Bean, navy, seed 0.600000 1.000 1.000 060304 1000 6C Bean, pink, seed 0.600000 1.000 1.000 0603042000 6C Bean, pinto, seed 0.600000 1.000 1.000 0603098000 6C Chickpea, seed 0.600000 1.000 1.000 0603098001 6C Chickpea, seed - babyfood 0.600000 1.000 1.000 0603099000 6C Chickpea, flour 0.600000 1.000 1.000 0603182000 6C Guar, seed 0.600000 1.000 1.000 0603182001 6C Guar, seed - babyfood 0.600 000 1.000 1.000 0603203000 6C Lentil, seed 0.600000 1.000 1.000 0801374000 8A Tomatillo 0.160000 1.000 1.000 0801375000 8A Tomato 0.160000 1.000 1.000 0801 375001 8A Tomato - babyfood 0.160000 1.000 1.000 0801376000 8A Tomato, paste 0.160000 1.000 1.000 0801376001 8A Tomato, paste - babyfood 0.160000 1.000 1.000 0801377000 8A Tomato, puree 0.160000 1.000 1.000 0801377001 8A Tomato, puree - babyfood 0.160000 1.000 1.000 0801378000 8A Tomato, dried 0.160000 14.300 1.000 0801378001 8A Tomato, dried - babyfood 0.1 60000 14.300 1.000 0801379000 8A Tomato, juice 0.160000 1.000 1.000 0801380000 8A Tomato, Tree 0.160000 1.000 1.000 0802148000 8BC Eggplant 1.500000 1.000 1.000 08 02234000 8BC Okra 1.500000 1.000 1.000 0802270000 8B Pepper, bell 1.500000 1.000 1.000 0802270001 8B Pepper, bell - babyfood 1.500000 1.000 1.000 0802271000 8B Pepper, bel l, dried 1.500000 1.000 1.000 0802271001 8B Pepper, bell, dried - babyfood 1.500000 1.000 1.000 0802272000 8BC Pepper, nonbell 1.500000 1.000 1.000 0802272001 8BC Pepper, nonbell - babyfood 1 .500000 1.000 1.000 0802273000 8BC Pepper, nonbell, dried 1.500000 1.000 1.000 0901075000 9A Cantaloupe 0.700000 1.000 1.000 0901187000 9A Honeydew melon 0.700000 1.000 1.000 0901399000 9A Watermelon 0.700000 1.000 1.000 0901400000 9A Watermelon, juice 0.700000 1.000 1.000 0902021000 9B Balsam pear 0.700000 1.000 1.000 0902088000 9B Chayote, fruit 0.700000 1.000 1.000 0902102000 9B Chinese waxgourd 0.700000 1.000 1.000 0902135000 9B Cucumber 0.700000 1.000 1.000 0902308000 9B Pumpkin 0.700000 1.000 1.000 0902309000 9B Pumpkin, seed 0.700000 1.000 1.000 0902356000 9B Squash, summer 0.700000 1.000 1.000 0902356001 9B Squash, summer - babyfood 0.700000 1.000 1.000 0902357000 9B Squash, winter 0.700000 1.000 1.000 0902357001 9B Squash, winter - babyfood 0.700000 1.000 1.000 1001108000 10A Citrus, oil 60.000000 1.000 1.000 1002199000 10B Lemon 0.260000 1.000 1.000Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 425997 :



### Page 17 of 22 1002200000 10B Lemon, juice 0.260000 1.000 1.000 1002200001 10B Lemon, juice - babyfood 0.260000 1.000 1.000 1002201000 10B Lemon, peel 0.260000 1.000 1.000 1002206000 10B Lime 0.260000 1.000 1.000 1002207000 10B Lime, juice 0.260000 1.000 1.000 1002207001 10B Lime, juice - babyfood 0.260000 1.000 1.00 0 1100007000 11 Apple, fruit with peel 0.500000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 1100008000 11 Apple, peeled fruit 0.500000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 1100008001 11 Apple, peeled fruit - babyfood 0.500000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 1100009000 11 Apple, dried 0.500000 8.000 1.000 PP#0F7

Full comment: PP#0F7696 1100009001 11 Apple, dried - bab yfood 0.500000 8.000 1.000 PP#0F7

Full comment: PP#0F7696 1100010000 11 Apple, juice 0.500000 1.300 1.000 PP#0F7

Full comment: PP#0F7696 1100010001 11 Apple, juice - babyfood 0.500000 1.300 1.000 PP#0F7

Full comment: PP#0F7696 1100011000 11 Apple, sauce 0.500000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 1100011001 11 Apple, sauce - babyfood 0.500000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 1100129000 11 Crabapple 0.500000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 1100173500 11 Goji berry 1.500000 1.000 1.000 110021000 0 11 Loquat 0.500000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 1100266000 11 Pear 0.380000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 1100266001 11 Pear - babyfo od 0.380000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 1100267000 11 Pear, dried 0.380000 6.250 1.000 PP#0F7

Full comment: PP#0F7696 1100268000 11 Pear, juice 0.380000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 1100268001 11 Pear, juice - babyfood 0.380000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 1100310000 11 Quince 0.500000 1 .000 1.000 PP#0F7

Full comment: PP#0F7696 1201090000 12A Cherry 2.000000 1.000 1.000 1201090001 12A Cherry - babyfood 2.000000 1.000 1.000 1201091000 12A Cherry, juice 2.000000 1.500 1.000 1201091001 12A Cherry, juice - babyfood 2.000000 1.500 1.000 1202012000 12B Apricot 2.000000 1.000 1.000 1202012001 12B Apricot - babyfood 2.000000 1.000 1. 000 1202013000 12B Apricot, dried 2.000000 6.000 1.000 1202014000 12B Apricot, juice 2.000000 1.000 1.000 1202014001 12B Apricot, juice - babyfood 2.000000 1.000 1.000 1202230000 12B Nec tarine 2.000000 1.000 1.000 1202260000 12B Peach 2.000000 1.000 1.000 1202260001 12B Peach - babyfood 2.000000 1.000 1.000 1202261000 12B Peach, dried 2.000000 7.000 1.000 1202261001 12B Peach, dried - babyfood 2.000000 7.000 1.000 1202262000 12B Peach, juice 2.000000 1.000 1.000 1202262001 12B Peach, juice - babyfood 2.000000 1.000 1.000 1203285000 12C Plum 2.000000 1.000 1.000 1203285001 12C Plum - babyfood 2.000000 1.000 1.000 1203286000 12C Plum, prune, fresh 2.000000 1.000 1.000 1203286001 12C P lum, prune, fresh - babyfood 2.000000 1.000 1.000 1203287000 12C Plum, prune, dried 2.000000 5.000 1.000 1203287001 12C Plum, prune, dried - babyfood 2.000000 5.000 1.000 1203288000 12C Plum, prune, juice 2.000000 1.400 1.000 1203288001 12C Plum, prune, juice - babyfood 2.000000 1.400 1.000 1301055000 13A Blackberry 10.000000 1.000 1.000 1301056000 13A Blackberry, juice 10.000000 1.000 1.000 1301056001 13A Blackberry, juice - babyfood 10.000000 1.000 1.000 1301058000 13A Boysenberry 10.000000 1.000 1.000 1301208000 13A Loganberry 10.000000 1.000 1.000Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 425997 :



### Page 18 of 22 1301320000 13A Raspberry 10.000000 1.000 1.000 1301320001 13A Raspberry - babyfood 10.000000 1.000 1.000 1301321000 13A Raspberry, juice 10.000000 1.000 1.000 1301321001 13A Raspberry, juice - babyfoo d 10.000000 1.000 1.000 1302057000 13B Blueberry 3.000000 1.000 1.000 1302057001 13B Blueberry - babyfood 3.000000 1.000 1.000 1302136000 13B Currant 3.000000 1.0 00 1.000 1302137000 13B Currant, dried 3.000000 1.000 1.000 1302149000 13B Elderberry 3.000000 1.000 1.000 1302174000 13B Gooseberry 3.000000 1.000 1.000 1302191000 13 B Huckleberry 3.000000 1.000 1.000 1304175000 13D Grape 0.810000 1.000 1.000 1304176000 13D Grape, juice 0.810000 1.200 1.000 1304176001 13D Grape, juice - babyfood 0.810000 1.200 1.000 1304179000 13D Grape, wine and sherry 0.810000 1.000 1.000 1304195000 13D Kiwifruit, fuzzy 1.800000 1.000 1.000 1307359000 13G Strawberry 5.000000 1 .000 1.000 1307359001 13G Strawberry - babyfood 5.000000 1.000 1.000 1307360000 13G Strawberry, juice 5.000000 1.000 1.000 1307360001 13G Strawberry, juice - babyfood 5.000000 1.000 1.000 1400003000 14 Almond 0.020000 1.000 1.000 1400003001 14 Almond - babyfood 0.020000 1.000 1.000 1400004000 14 Almond, oil 0.020000 1.000 1.000 1400004001 14 Almond, oil - babyfood 0.020000 1.000 1.000 1400282000 14 Pistachio 0.100000 1.000 1.000 1901028000 19A Basil, fresh leaves 3.000000 1.000 1.000 1901028001 19A Basil, fresh leaves - babyfood 3.000000 1.000 1.000 1901029000 19A Basil, dried leaves 15.000000 1.000 1.000 1901029001 19A Basil, dried leaves - babyfood 15.000000 1.000 1.000 1901102500 19A Chive, dried leaves 15.000000 1.000 1.000 190111800 0 19A Cilantro, leaves 3.000000 1.000 1.000 1901118001 19A Cilantro, leaves - babyfood 3.000000 1.000 1.000 1901144000 19A Dillweed 3.000000 1.000 1.000 1901184000 19A Herbs, other 3.000000 1.000 1.000 1901184001 19A Herbs, other - babyfood 3.000000 1.000 1.000 1901202000 19A Lemongrass 3.000000 1.000 1.000 1901220000 19A Marjoram 3.000000 1.000 1.000 1901220001 19A Marjoram - babyfood 3.000000 1.000 1.000 1901249000 19A Parsley, dried leaves 170.000000 1.000 1.000 1901249001 19A Parsley, dried leaves - babyfood 170.000000 1.000 1.000 1901334 000 19A Savory 3.000000 1.000 1.000 2001319000 20A Rapeseed, oil 0.030000 1.000 1.000 2001319001 20A Rapeseed, oil - babyfood 0.030000 1.000 1.000 3100046000 31 Beef, meat bypro ducts 0.020000 1.000 1.000 3100046001 31 Beef, meat byproducts - babyfood 0.020000 1.000 1.000 3100048000 31 Beef, kidney 0.020000 1.000 1.000 3100049000 31 Beef, liver 0.0200 00 1.000 1.000 3100049001 31 Beef, liver - babyfood 0.020000 1.000 1.000 3200170000 32 Goat, meat byproducts 0.020000 1.000 1.000 3200172000 32 Goat, kidney 0.020000 1.000 1.000 32001 73000 32 Goat, liver 0.020000 1.000 1.000 3500340000 35 Sheep, meat byproducts 0.020000 1.000 1.000 3500342000 35 Sheep, kidney 0.020000 1.000 1.000 3500343000 35 Sheep, liver 0.020000 1.000 1.000 8601000000 86A Water, direct, all sources 0.024650 1.000 1.000 8602000000 86B Water, indirect, all sources 0.024650 1.000 1.000 9500001000 O Acerola 1.50 0000 1.000 1.000 9500016000 O Artichoke, globe 4.000000 1.000 1.000 9500020000 O Avocado 1.200000 1.000 1.000 9500074000 O Canistel 1.200000 1.000 1.000 950 0151000 O Feijoa 1.500000 1.000 1.000 9500177000 O Grape, leaves 0.810000 1.000 1.000 9500178000 O Grape, raisin 5.000000 1.000 1.000 9500183000 O Guava 1.500000 1.000 1.000 9500183001 O Guava - babyfood 1.500000 1.000 1.000 9500209000 O Longan 2.000000 1.000 1.000 9500211000 O Lychee 2. 000000 1.000 1.000 9500212000 O Lychee, dried 2.000000 1.850 1.000 9500215000 O Mango 1.200000 1.000 1.000 9500215001 O Mango - babyfood 1.200000 1.000 1.000Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 425997 :



### Page 19 of 22 9 500216000 O Mango, dried 1.200000 1.000 1.000 9500217000 O Mango, juice 1.200000 1.000 1.000 9500217001 O Mango, juice - babyfood 1.200000 1.000 1.000 9500245000 O Papaya 1.200000 1.000 1.000 9500245001 O Papaya - babyfood 1.200000 1.000 1.000 9500246000 O Papaya, dried 1.200000 1.800 1.000 9500247000 O Papaya, juice 1.200000 1.500 1.000 9500252000 O Passionfruit 1.500000 1.000 1.000 9500252001 O Passionfruit - babyfood 1.500000 1.000 1.000 9500253000 O Passionfruit, juice 1.500000 1.000 1.000 9500253001 O Passionfruit, juice - babyfood 1.500000 1.000 1.000 9500289000 O Pomegranate 10.000000 1.000 1.000 9500333000 O Sapote, Mamey 1.200000 1.000 1.000 9500351000 O Spanish lime 2.000000 1.000 1.000 9500358000 O Starfruit 1.500000 1.000 1.000 9500398000 O Watercress 20.000000 1.000 1.000Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 425997 :



### Page 20 of 22 Attachment 3 Res ults of Acute DEEM - FCI D Dietary Exposure Analy sis US EPA Ver. 3.18, 03 - 08 - d DEEM - FCID ACUTE Analysis for CYPRODINIL NHANES 2003 - 2008 2 - Day Residue file: 288202 Acute Food and Water.R0 8 Adjustment factor #2 NOT used. Analysis Date: 04 - 09 - 2015/09:51:29 Residue file dated: 04
- 09 - 2015/09:44:19 RAC/FF intake summed over 24 hours Run Comment: ""

=============================================================================== Summary c alculations -- per capita: 95th Percentile 99th Percentile 99.9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- - ------- Total US Population: 0.095198 4.76 0.181584 9.08 0.310238 15.51 All Infants: 0.101588 5.08 0.168263 8.41 0.529152 26.46 Children 1 - 2: 0.172629 8.63 0.277215 13.86 0.443582 22.18 Children 3 - 5: 0.158663 7.93 0.253670 12.68 0.412075 20.60 Children 6 - 12: 0.083374 4.17 0.178317 8.92 0.276162 13.81 Youth 13 - 19: 0.071553 3.58 0.141338 7.07 0.295995 14.80 Adults 20 - 49: 0.091866 4.59 0.182137 9.11 0.314326 15.72 Adults 50 - 99: 0.091595 4.58 0.154312 7.72 0.272418 1 3.62 Female 13 - 49: 0.096706 4.84 0.187550 9.38 0.327236 16.36 

### FOOD ONLY US EPA Ver. 3.18, 03 - 08 - d DEEM - FCID ACUTE Analysis for CYPRODINIL NHANES 2003 - 2008 2 - Day Residue file: 288202 Acute Food Only.R08 Adjustment factor #2 NOT used. Analysis Date: 04 - 09 - 2015/09:54:10 Residue file dated: 04
- 09 - 2015/09:46:11 RAC/FF intake summed over 24 hours Run Comment: ""

=============================================================================== Summary calculations -- per capita: 95th Percentile 99th Percentile 99.9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- -------- Total US Population: 0.094428 4.72 0.179943 9.00 0.309314 15.47 All Infants: 0.099629 4.98 0.167443 8.37 0.528808 26.44 Children 1 - 2: 0.172240 8.61 0.275992 13.80 0.445942 22.30 Children 3 - 5: 0.157732 7.89 0.254669 12.73 0.408825 20.44 Children 6 - 12: 0.082435 4.12 0.177091 8.85 0.274520 13.73 Youth 13 - 19: 0.071135 3.56 0.139976 7.00 0.295949 14.80 Adults 20 - 49: 0.091013 4.55 0.180252 9.01 0.312594 15.63 Adults 50 - 99: 0.090599 4.53 0.153660 7.68 0.270453 13.52 Female 13 - 49: 0.095958 4.80 0.187084 9.35 0.325861 16.29Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 425997 :



### Page 21 of 22 Attachment 4 Results of Chronic DEEM - FCI D Dietary Exposure Analy sis US EPA Ver. 3.16, 03 - 08 - d DEEM - FCID Chronic analysis for CYPRODINIL NHANES 2003 - 2008 2 - day Residue file name: C: \ Users \ tmorton \ Documents \ My Files \ DEEM Files \ 288202 Cyprodinil \ Cyprodinil 4E8273 \ 288202 Chronic Food and Water.R08 Adjustment factor #2 used. Analysis Date 04 - 09 - 2015/09:48:31 Residue file dated: 04 - 09 - 2015/09:43:22 Reference dose (RfD, Chronic) = .027 mg/kg bw/day

=============================================================================== Total exposure by population subgroup

------------------------ ------------------------------------------------------- Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- ---------------- Total US Population 0.007794 28.9% Hispa nic 0.007303 27.0% Non - Hisp - White 0.008032 29.7% Non - Hisp - Black 0.006325 23.4% Non - Hisp - Other 0.009383 34.8% Nursing Infants 0.008687 32.2% Non - Nursing Infants 0.014986 55.5% Female 13+ PREG 0.006602 24.5% Children 1 - 6 0.018324 67.9% Children 7 - 12 0.007696 28.5% Male 13 - 19 0.004191 15.5% Female 13 - 19/NP 0.005153 19.1% Male 20+ 0.006066 22.5% Female 20+/NP 0.007731 28.6% Seniors 55+ 0.007840 29.0% All Infants 0.013042 48.3% Female 13 - 50 0.006754 25.0% Children 1 - 2 0.023045 85.4% Children 3 - 5 0.016592 61.5% Children 6 - 12 0.008522 31.6% Youth 13 - 19 0.004665 17.3% Adults 20 - 49 0.006327 23.4% Adults 50 - 99 0.007772 28.8% Female 13 - 49 0.006706 24.8%

-------------------------------------------------------------------------------Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 425997 :



### Page 22 of 22 **FOOD ONLY** US EPA Ver. 3.16, 03 - 08 - d DEEM - FCID Chronic analysis for CYPRODINIL NHANES 2003 - 2008 2 - day Residue file name: C: \ Users \ tmorton \ Documents \ My Files \ DEEM Files \ 28820 2 Cyprodinil \ Cyprodinil 4E8273 \ 288202 Chronic Food Only.R08 Adjustment factor #2 used. Analysis Date 04 - 09 - 2015/09:49:01 Residue file dated: 04
- 09 - 2015/09:47:27 Reference dose (RfD, Chronic) = .027 m g/kg bw/day

=============================================================================== Total exposure by population subgroup

------------------------------------------------------------------------------- Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- ---------------- Total US Population 0.007277 27.0% Hispanic 0.006810 25.2% Non - Hisp - Whit e 0.007501 27.8% Non - Hisp - Black 0.005899 21.8% Non - Hisp - Other 0.008788 32.5% Nursing Infants 0.0 08220 30.4% Non - Nursing Infants 0.013270 49.1% Female 13+ PREG 0.006116 22.7% Children 1 - 6 0.017663 65.4% Childre n 7 - 12 0.007266 26.9% Male 13 - 19 0.003836 14.2% Female 13 - 19/NP 0.004755 17.6% Male 20+ 0.005585 20.7% Female 20+/NP 0.007189 26.6% Seniors 55+ 0.007341 27.2% All Infants 0.011711 43.4% Female 13 - 50 0.006241 23.1% Children 1 - 2 0.022300 82.6% Children 3 - 5 0.015965 59.1% Children 6 - 12 0.008070 29.9% Youth 13 - 19 0.004289 15.9% Adults 20 - 49 0.005812 21.5% Adults 50 - 99 0.007263 26.9% Female 13 - 49 0.006193 22.9%

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