Support Documents for 

Significant New Use Rules (SNUR) on 

Premanufacture Notice (PMN) 

P-12-373 

EPA Docket EPA-HQ-OPPT-2012-0740 

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Index 

A-001 Structure Activity Team (SAT) Report for 

 PMN P-12-373 

A-002 Initial Review Engineering Report for 

 PMN P-12-373 

A-003 Initial Review Exposure Report for 

 PMN P-12-373 

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A-001 

Structure Activity Team (SAT) Report 

for PMN P-12-373 

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SAT Report

PMN Number: P-12-0373

SAT Date: 6/5/2012

Print Date: 7/3/2012

Related cases: Yes

Health related cases: 

Ecotox related cases: 

Concern levels:

Type of Concern: Health Eco Comments

Level of Concern: 1-2 1

 Persistence Bioaccum Toxicity Comments

1 1 2 PMN

3 1 2 Hyd Pdt

Exposure Based Review:

Health: No

Ecotox: No

Routes of exposure: Health: Dermal Drinking Water Inhalation 

Ecotox: No releases to water

Fate: ; Hyd Pdt negl

Keywords:

 Keywords: SENS, IRR, ONCO, MUTA, DEVEL

Summary of Assessment:

 Fate:

Fate Summary: P-12-0373

FATE: 

Solid 

S = Reacts

Hydrolysis half-life = hr

VP < 1.0E-6 torr at 25 C (E)

BP > 400 C (E)

H < 1.00E-8 (E)

POTW removal (%) = PMN 90-99 via hydrolysis; then Hyd Pdt 90 via sorption

Time for complete ultimate aerobic biodeg = Hyd Pdt > mo

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Sorption to soils/sediments = Hyd Pdt v.strong

PBT Potential: PMN P1B1; Hyd Pdt P3B1

*CEB FATE: Migration to ground water = Hyd Pdt negl

 Health:

 Health Summary: Absorption is nil all routes as the neat material and poor 

all routes for the low molecular weight fraction when in solution 

based on physical/chemical properties. Expect Michael addition to the acrylate. There is 

concern for dermal and respiratory sensitization and irritation based on both the acrylate and 

moieties. There is also concern for mutagenicity, oncogenicity, and developmental 

toxicity for the low molecular weight acrylates. Low moderate concern. 

 Ecotox:

Test Organism Test 

Type

Test End 

Point

Predicted Measured Comments

fish 96-h LC50 *

daphnid 48-h LC50 *

green algal 96-h EC50 *

fish _ chronic value *

daphnid _ chronic 

value

*

algal _ chronic 

value

*

Sewage Sludge 3-h EC50 _

Sewage Sludge _ Chronic 

Value

_

Ecotox Values Comments: Predictions are based on SARs for nonionic polymers; SAR 

chemical class = polymer-nonionic solid 

with mp unknown (P); S = reacts with water at 20 C (P); pH7; effective concentrations based 

on 100% active ingredients and mean measured concentrations; hardness <150.0 mg/L as 

CaCO3; and TOC <2.0 mg/L;

Factors Values Comments

Assessment Factor 10

Concentration of Concern 

(ppb)

*

SARs nonionic polymers

SAR Class polymer-nonionic

Ecotox Category Nonionic Polymers

Ecotox Factors Comments: 

 SAT Chair: Becky Jones

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A-002 

Initial Review Engineering Report 

for PMN P-12-373 

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INITIAL REVIEW ENGINEERING REPORT 

PMN: 12-0373

Focus Ready Draft 6/14/2012

ENGINEER: Jon \ AG

PV (kg/yr): 

SUBMITTER: 

USE:

OTHER USES:

 Label: No

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SAT (concerns) (06/05/2012):

Related Cases and Related Cases and Misc SAT Info:

Migration to groundwater: Hyd Pdt Negligible

PBT rating: P3B1T2 PMN: P1B1T2 // Hyd Pdt: P3B1T2

Health: 1-2 Dermal, Drinking Water, Inhalation

Eco: 1 No releases to Water

OCCUPATIONAL EXPOSURE RATING: 1B

NOTES & KEY ASSUMPTIONS:

Generated by the 06/07/2005 version of ChemSTEER. 

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INITIAL REVIEW ENGINEERING REPORT 

PMN: 12-0373

ENVIRONMENTAL RELEASES ESTIMATE SUMMARY

OCCUPATIONAL EXPOSURES ESTIMATE SUMMARY

Tot. # of workers exposed via assessed routes: 0

Basis:

Inhalation:

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Dermal:

INITIAL REVIEW ENGINEERING REPORT 

PMN: 12-0373

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A-003 

Initial Review Exposure Report 

for PMN P-12-373 

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INITIAL REVIEW EXPOSURE REPORT (IRExR) 

 Chemical ID: P-12-0373 Reviewer: Cinalli/BC 

 

 

Results Table: Dose, Concentration, and Days Exceeded Results Summary 

Exposure 

Scenario1 

Water Landfill Stack Air Fugitive Air 

Drinking Water Fish Ingestion 

ADR LADD ADR LADD 7Q104

CC = 

1000 

PDM 

Days 

Exceeded

LADD ADR LADD ADR LADD 

Release 

activity(ies)2; 

exposure 

calculation(s)

3 

mg/kg/day mg/kg/day mg/kg/day mg/kg/day μg/l # Days mg/kg/day mg/kg/day mg/kg/day mg/kg/day mg/kg/day 

Max 

ADR 

1.63E-05 --- --- --- --- --- --- --- --- --- --- 

 Max 

LADD 

--- 4.13E-07 --- --- --- --- --- --- --- --- --- 

1 Exposure scenario titles consist of release activity followed by exposure calculation abbreviation. 

2 Release activities are from engineering report's Manufacturing (Mfg), Processing (Proc) and Use release activity 

labels. Multiple release activities are combined in one exposure scenario if their releases occur at same location. 

3 Exposure calculations are Acute Dose Rate (ADR), Lifetime Average Daily Dose (LADD), and Probabilistic 

Dilution Model (PDM). There may be one, two, or all three exposure calculations per exposure scenario. 

 CC is the aquatic concentration of concern. 

4 This column displays concentration values for the 7Q10 streamflow, which is defined as the average daily 

streamflow of the seven consecutive days of lowest flow within a ten year period. 

Remarks: 

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 INITIAL REVIEW EXPOSURE REPORT 

Chemical ID: P-12-0373 Assessor: Cinalli/BC 

ENVIRONMENTAL RELEASES 

 Scenario#:1 Number of Release Sites: 

 Release Activity: : Max ADR 

 Release Description: WATER LANDFILL 

Non-sludge/Sludge 

STACK FUGITIVE 

Total Releases: 

(kg/yr) (kg/yr) (kg/yr) (kg/yr) 

Non-sludge/Sludge 

Release Days/yr: 

Per Site Release: 

(kg/site/day) (kg/site/day) (kg/site/day) (kg/site/day) 

Remarks: 

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INITIAL REVIEW EXPOSURE REPORT 

 Chemical ID: P-12-0373 

SIC-CODE BASED HUMAN AND AQUATIC EXPOSURES TO SURFACE WATER RELEASES 

SCENARIO #: 1 Number of Sites: RELEASE ACTIVITY: Max 

ADR 

SIC-CODE DESCRIPTION: POTW (Indust., includes POTWs which receive ind. disch.) 

SIC-CODE (S): Subset of 4952 EXPOSED POPULATION: Adult 

WWT 

REMOVAL 

(%) 

RELEASE 

DAYS 

PRETREATMENT 

RELEASE 

(kg/site/day) 

POSTTREATMENT 

RELEASE 

(kg/site/day) 

DWT 

(%) BCF 

(L/kg) 

 0.00 0.00 

AQUATIC EXPOSURE ESTIMATES - SURFACE WATER 

PLANT 

TYPE 

% ILE 

FACILITY 

STREAM FLOW (MLD) STREAM CONC. (μg/l) 

Harmonic 

Mean 30Q5 7Q10 1Q10 

Harmonic 

Mean 30Q5 7Q10 1Q10 

ALL 50 288.00 123.84 78.18 66.05 9.03E-03 2.10E-02 3.33E-02 3.94E-02

ALL 10 39.60 13.29 7.76 7.57 6.57E-02 0.20 0.34 0.34 

DRINKING WATER AND FISH INGESTION EXPOSURE ESTIMATES 

Exposure Units 

Drinking Water Results Drinking 

Water Units Fish Ingestion Results 

Fish 

Ingestion 

Units 

50% 10% 50% 10% 

Cancer 

LADDpot 3.22E-08 2.34E-07 mg/kg/day 0.00 0.00 mg/kg/day 

LADCpot 1.65E-06 1.20E-05 mg/L 0.00 0.00 mg/kg 

Acute 

ADRpot 1.75E-06 1.63E-05 mg/kg/day 0.00 0.00 mg/kg/day 

SIC Code Comments: 

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 INITIAL REVIEW EXPOSURE REPORT 

Chemical ID: P-12-0373 Assessor: Cinalli/BC 

ENVIRONMENTAL RELEASES 

 Scenario#:2 Number of Release Sites: 

 Release Activity: Max LADD 

 Release Description: WATER LANDFILL 

Non-sludge/Sludge 

STACK FUGITIVE 

Total Releases: 

(kg/yr) (kg/yr) (kg/yr) (kg/yr) 

Non-sludge/Sludge 

Release Days/yr: 

Per Site Release: 

(kg/site/day) (kg/site/day) (kg/site/day) (kg/site/day) 

Remarks: 

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INITIAL REVIEW EXPOSURE REPORT 

 Chemical ID: P-12-0373 

SIC-CODE BASED HUMAN AND AQUATIC EXPOSURES TO SURFACE WATER RELEASES 

SCENARIO #: 2 Number of Sites: RELEASE ACTIVITY Max 

LADD 

SIC-CODE DESCRIPTION: POTW (Indust., includes POTWs which receive ind. disch.) 

SIC-CODE (S): Subset of 4952 EXPOSED POPULATION: Adult 

WWT 

REMOVAL 

(%) 

RELEASE 

DAYS 

PRETREATMENT 

RELEASE 

(kg/site/day) 

POSTTREATMENT 

RELEASE 

(kg/site/day) 

DWT 

(%) BCF 

(L/kg) 

 0.00 0.00 

AQUATIC EXPOSURE ESTIMATES - SURFACE WATER 

PLANT 

TYPE 

% ILE 

FACILITY 

STREAM FLOW (MLD) STREAM CONC. (μg/l) 

Harmonic 

Mean 30Q5 7Q10 1Q10 

Harmonic 

Mean 30Q5 7Q10 1Q10 

ALL 50 288.00 123.84 78.18 66.05 N/A N/A N/A N/A 

ALL 10 39.60 13.29 7.76 7.57 N/A N/A N/A N/A 

DRINKING WATER AND FISH INGESTION EXPOSURE ESTIMATES 

Exposure Units 

Drinking Water Results Drinking 

Water Units Fish Ingestion Results 

Fish 

Ingestion 

Units 

50% 10% 50% 10% 

Cancer 

LADDpot 5.68E-08 4.13E-07 mg/kg/day 0.00 0.00 mg/kg/day 

LADCpot 2.92E-06 2.12E-05 mg/L 0.00 0.00 mg/kg 

Acute 

ADRpot N/A N/A mg/kg/day N/A N/A mg/kg/day 

SIC Code Comments: 

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