Appendix B. Table of Generic Data Requirements and Studies Used to Make the 

Reregistration Decision for Chloropicrin (PC 081501)

GUIDE TO APPENDIX B

Appendix B contains a listing of data requirements which support the 

reregistration for the active ingredient chloropicrin covered by this RED. It contains 

generic data requirements that apply to chloropicrin in all products, including data 

requirements for which a “typical formulation” is the test substance.

The data table is organized in the following formats:

1. Data requirement (Column 1). The data requirements are listed in the order in 

which they appear in 40 CFR 158. The reference numbers accompanying each 

test refer to the test protocols set in the Pesticide Assessment Guidance, which is 

available from the National Technical Information Service, 5285 Port Royal 

Road, Springfield, VA 22161. (703) 487-4650.

2. Use Pattern (Column 2). This column indicates the use patterns for which the 

data requirements apply. The following letter designations are used for the given 

use patterns.

A. Terrestrial food

B. Terrestrial feed

C. Terrestrial non-food

D. Aquatic food

E. Aquatic non-food outdoor

F. Aquatic non-food industrial

G. Aquatic non-food residential

H. Greenhouse food

I. Greenhouse non-food

J. Forestry

K. Residential

L. Indoor food

M. Indoor non-food

N. Indoor medical

O. Indoor residential

3. Bibliographic Citation (Column 3). If the Agency has acceptable data in its files, this 

column lists the identifying number of each study. This normally is the Master Record 

Identification (MRID) number, but may be a “GS” number is no MRID number has been 

assigned. Refer to the Bibliography appendix for a complete citation of the study.
Data Requirement

Use Patterns Citations New 

Guideline 

Number

Old 

Guideline 

Number

Description

PRODUCT CHEMISTRY

830.1550 61-1 Product Identity and Composition All 43090201, 43091301,

43091401

830.1600 61-2A Description of materials used to 

produce the product All

44230001, 43090201, 

43091301, 43091401, 

42400001, 42400002

830.1620 61-2B Description of production process All

43090201, 43091301, 

43091401, 42400001, 

42400002

830.1650 61-2B Description of formulation process All 44230001

830.1670 61-2B Formation of Impurities All 43090201, 43091301, 

43091401, 42400000

830.1700 62-1 Preliminary Analysis All 43097901, 43137001, 

43091402, 42400002

830.1750 62-2 Certification of Limits All 43090202

830.1800 62-3 Analytical Method All 43090202, 43137002, 

43091402, 43137001

830.6302 63-2 Color All 43097902, 43137002, 

43133101, 42427001

830.6303 63-3 Physical State All 43097902, 43137002, 

43133101, 42427001

830.6304 63-4 Odor All 42427001

830.6313 63-13

Stability to normal and elevated 

temperatures, metals, and metal 

ions

All 43097902, 43137002, 

43133101, 42427001

830.6314 63-14 Oxidation/reduction: chemical 

incompatibility All 43434601

830.6315 63-15 Flammability All 00013198

830.6317 63-17 Storage stability All 00013198

830.6320 63-20 Corrosion characteristics All 00013198

830.7100 63-18 Viscosity All 43434601

830.7220 63-6 Boiling Point/boiling range All 43097902, 43137002, 

4313301, 42427001

830.7300 63-7 Density All 43097902, 43137002, 

43133101, 42427001

830.7505 Ultraviolet/visible Absorption All

Study called in via the 

DCI, however EPA 

granted a waiver request 

in May 2011. 

830.7550 63-11 Partition coefficient, shake flask 

method All 43022402, 43022402

830.7840 63-8 Solubility All 43097902, 43137002, 

43133101, 42427001

830.7860 63-8

Water solubility, generator column 

method All

43097902, 43137002, 

43133101, 42427001, 

43613901
Data Requirement

Use Patterns Citations New 

Guideline 

Number

Old 

Guideline 

Number

Description

830.7950 63-9 Vapor Pressure All 43097902, 43137002, 

43133101, 42427001

ECOLOGICAL EFFECTS

850.1010 72-2 

Acute Toxicity to Freshwater 

Invertebrates C, I 

130704 (supplemental),

data gap submitted 

48442401 in response to 

DCI 

850.1025 72-3B Estuarine/Marine Toxicity –

Mollusk C, I

Data gap – submitted 

48442404 in response to 

DCI

850.1035 72-3C Estuarine/Marine Toxicity –

Shrimp C, I 

Data gap – submitted 

48442403 in response to 

DCI

850.1075 72-1A Fish Toxicity Bluegill C, I 47102102

(supplemental)

850.1075 72-1 B Fish Toxicity Rainbow Trout C, I

47102102

(supplemental), 

43066701(supplemental)

850.1075 72-3A Estuarine/Marine Toxicity – Fish C, I

Data gap – submitted 

48442402, 48442405, 

48442406 in response to 

DCI

850.3020 141-1Honey bee acute contact LD50 C, I

Data gap – submitted 

48442473 in response to 

DCI

850.4100 122-1 Seedling Emergence, Tier 1 C, I

Data gap – submitted 

48442802 in response to 

DCI

850.4150 122-1 Vegetative Vigor, Tier 1 C, I

Data gap – submitted 

48442802 in response to 

DCI

850.4400 123-2 Aquatic Plant Toxicity C, I

Data gap – submitted 

48442801 in response to 

DCI

NonGuideline 

Study

NonGuideline 

Study

Avian Acute Inhalation C, I 

Data gap – submitted 

48442803 in response to 

DCI

TOXICOLOGY

870.1100 81-1 Acute Oral Toxicity - Rat C, I 05014376

870.1200 81-2

Acute Dermal Toxicity –

Rabbit/Rat C, I 05014376

870.1300 81-3

Acute Inhalation Toxicity –

Rat/Mouse C, I 45117901, 45117902

870.2500 81-5 Primary Skin Irritation C, I 05014376

870.3465 82-5 90- Day Inhalation Toxicity C, I 43063201

870.3465 82-4 13-Week Inhalation – Mouse/Rat C, I 43063201

870.3700A 83-3A Developmental Toxicity – Rat C, I 42740602

870.3700B 83-3B Developmental Toxicity – Rabbit C, I 42740601

870.3800 83-4 2-Generation Reproduction – Rat C, I 43391901, 46427801

870.4100A 83-1 Chronic Toxicity Rodents C, I 43744301
Data Requirement

Use Patterns Citations New 

Guideline 

Number

Old 

Guideline 

Number

Description

870.4100B 83-1B Chronic Feeding Toxicity Study -

Non-rodent C, I 43196301

870.4200 83-2 Carcinogenicity - Rat C, I 43632201, 05014915

870.4300 83-5

Combined Chronic 

Toxicity/Carcinogenicity: Rats C, I 43755301

870.5100 84-2 Bacterial Reverse Mutation Test C, I 41960801

870.5300 84-2

Mutagenic –Lymphoma Mutation –

Mouse C, I 41960803

870.5375 84-2

Cytogenetis – CHO Chromosomal 

Aberrations C, I 41960802

870.5395 84-2 Unscheduled DNA Synthesis-Rat C, I 41960804

870.7800 85-7 Immunotoxicity C, I

Study called in via the 

DCI, however EPA 

granted a waiver request 

in May 2011.

Non-guideline 

study

Nonguideline 

study

Acute Inhalation (human study) C, I 46443801

Non-guideline 

study

Nonguideline 

study

BMC concentration analysis C, I 46614801

Non-guideline 

study

Nonguideline 

study

Quantification of the 

chemosensations produced from 

chloropicrin vapors

C, I 451178901

ENVIRONMENTAL FATE

835.1240 163-1 Leaching/Adsorption/Desorption C, I 44191301

835.1410 163-2 Laboratory Volatilization (from 

Soil) Study C, I 43798601

835.2120 161-1 Hydrolysis C, I 43022401 

835.2240 161-2 Photodegradation - Water C, I 42900201

835.2370 161-4 Photolysis Air C, I 05007865

835.4100 162-1 Aerobic Soil Metabolism C, I 43613901

835.4400 162-3 Anaerobic Aquatic Metabolism C, I 43759301

835.6100 164-1 Terrestrial Field Dissipation C, I 43085101

835.8100 163-3 Field Volatility (from soil) Study C, I 

44149201, 47576901, 

47295202, 47295203, 

47295204, 45112902, 

46420201, 45112901, 

47456001, 47679301, 

48033801, 48011601, 

47820001, 47813801, 

48006001, 48107601, 

47813901, 47456001, 

48087401, 47576901

OCCUPATIONAL AND RESIDENTIAL EXPOSURE

875.1300 232 Inhalation Exposure C

44149201, 45112901

(data gap for EFED) 

875.2500 133-4

Inhalation (Passive Dosimetry) 

Exposure C 44149201, 45112901

OTHER-No Category

Special Study NA Fumigant Buffer Zone Posting C, I Data gap satisfied May 
Data Requirement

Use Patterns Citations New 

Guideline 

Number

Old 

Guideline 

Number

Description

Signs 2011

Special Study NA Community Outreach and 

Education Program C, I Data gap 

Special Study NA Certified Applicator Training C, I Data gap 

Special Study NA Safe Handler Information C, I Data gap satisfied 2010