Cyprodinil (PC Code 288202) Dietary Exposure and Risk Assessment DP # 425997: 

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

Office of Chemical Safety and Pollution Prevention

MEMORANDUM

July 1, 2015

SUBJECT: Cyprodinil – Acute and Chronic Dietary and Drinking Water Exposure and Risk 

Assessment For The Expansions of Existing Crop Group/Representative 

Commodity Uses to Stone Fruit Group 12-12, and Adding New Uses on the 

Artichoke, Guava, Pomegranate, Passionfruit, Feijoa, Jaboticaba, Wax Jambu, 

Starfruit, and Acerola and Amended Uses on Greenhouse Cucumbers and Small 

Tomatoes. 

PC Code: 288202 DP Barcode: D425997

Decision No.: 490951 Registration No.: 100-811, 100-1317, 100-828, & 

100-953

Petition No.: 4e8273 Regulatory Action: Section 3 

Risk Assessment Type: Dietary Case No.: NA

TXR No.: NA CAS No: 121552-61-2

MRID No.: NA 40 CFR: 180.532

FROM: Thurston G. Morton, Chemist

Risk Assessment Branch IV

Health Effects Division (7509P)

THROUGH: Pete Savoia, Chemist

Meheret Negussie, Chemist

Dietary Exposure Science Advisory Council (DESAC),

and

Charles Smith, Acting Branch Chief

Health Effects Division (7509P)

TO: Laura Nollen/Barbara Madden

Risk Integration, Minor Use & Emergency Response Branch 

Registration Division (RD) (7505P)
Cyprodinil (PC Code 288202) Dietary Exposure and Risk Assessment DP # 425997: 

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This document provides an acute and chronic dietary and drinking water risk analyses of 

exposures resulting from use of cyprodinil as a fungicide on food crops. This assessment 

supports requests for the expansion of existing crop group fruit, stone, group 12-12, and adding 

new uses on the globe artichoke, guava, pomegranate, passionfruit, feijoa, jaboticaba, wax 

jambu, starfruit, and acerola and amended uses on greenhouse cucumbers and small tomatoes.

Executive Summary

Acute and chronic dietary risk assessments were conducted for cyprodinil using the Dietary

Exposure Evaluation Model (DEEM-FCID, Version 3.18), which incorporates consumption data 

from USDA’s National Health and Nutrition Examination Survey, What We Eat in America, 

(NHANES/WWEIA). This dietary survey was conducted from 2003 to 2008.

 

Acute Dietary Exposure Analysis Results and Characterization

A conservative acute dietary exposure analysis was performed for the general U.S. population 

and various population subgroups. Tolerance level residues and 100 % crop treated assumptions 

were used. DEEM default and empirical processing factors were used to modify the tolerance 

values. The acute analysis incorporated the 1 in 10 year peak surface drinking water estimate 

from application of cyprodinil to grapes. The resulting 95th percentile acute exposure estimates 

are not of concern for the general U.S. population or any of the other population subgroups. The 

subgroup with the highest risk estimate is children 1-2 years old with a % acute population 

adjusted dose (aPAD) of 8.6%. The % aPAD for the general U.S. population is 4.8%. 

Chronic Dietary Exposure Analysis Results and Characterization

A partially refined chronic dietary exposure analysis was performed for the general U.S. 

population and various population subgroups. For the chronic dietary analysis, tolerance level 

residues for most commodities; average field trial residues for pome fruit, head lettuce, leaf 

lettuce, spinach, tomato, and grapes; and 100% crop treated assumptions were used. DEEM 

default and empirical processing factors were used to modify the tolerance values. The chronic

analysis incorporated the 10 year average surface drinking water estimate from application of 

cyprodinil to grapes. Chronic dietary risk estimates are not of concern for the general U.S. 

population or any of the other population subgroups. The subgroup with the highest risk estimate 

is children 1-2 years old with a % chronic PAD (cPAD) of 85%. The % cPAD for the general 

U.S. population is 29%.

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). 
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This dose is referred to as the PAD. The PAD is equivalent to the point of departure (POD, 

NOAEL, LOAEL, etc) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in 

more detail are available on the EPA/pesticides web site: “Available Information on Assessing 

Exposure from Pesticides, A User’s Guide,” 6/21/2000, web link: 

http://www.epa.gov/fedrgstr/EPA_PEST/2000/July/Day_12/6061.pdf ; or see SOP 99.6 

(8/20/99).

The most recent dietary risk assessment for cyprodinil was conducted by T. Morton (3-May2012; DP#390233).

II. Residue Information

Residues of Concern 

The metabolism of cyprodinil has been studied in apple, peach, potato, tomato, and wheat. The 

residue of concern in plants is the parent compound cyprodinil as determined by the HED 

Metabolism Assessment Review Committee (MARC) (D243198, G. Kramer, 3/11/98). The 

nature of the residue in ruminants is adequately understood based on acceptable lactating goat 

metabolism studies. HED has concluded that the residues of concern for both risk assessment 

and the tolerance definition should include the combined residues of cyprodinil and free and 

conjugated CGA-304075, expressed in parent equivalents (D345970 and D345182, G. Kramer, 

6/4/08). The water residues of concern as determined by MARC are the parent and CGA 249287 

(4-cyclopropyl-6-methylpyrimidin-2-amine) (D292557, 6/8/03). HED continues to consider 

these metabolites and degradates to be the residues of concern.

Table 1: Summary of Residues of Concern for Cyprodinil

Matrix Residues of Concern

For Risk Assessment For Tolerance Expression

Plants cyprodinil cyprodinil

Livestock cyprodinil and CGA-304075 cyprodinil and CGA-304075

Water cyprodinil and CGA 249287 NA

Established/Recommended Tolerances

Permanent tolerances are established (40 CFR §180.532(a)) for residues of cyprodinil per se

in/on a variety of crop commodities, at levels ranging from 0.02 ppm in/on almonds to 340 ppm 

in citrus oil. Recommended tolerances for the proposed amended/new uses are as follows

(D421157, T. Morton, 04/23/2015). 
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Artichoke..... ...............................................................................................4.0 ppm

Guava...........................................................................................................1.5 ppm

Passionfruit............................................................................1.5 ppm

Feijoa...................................................................................1.5 ppm 

Jaboticaba..............................................................................1.5 ppm 

Wax Jambu............................................................................1.5 ppm

Starfruit .......................................................................................................1.5 ppm

Acerola.........................................................................................................1.5 ppm

Pomegranate ................................................................................................7.0 ppm

Fruit, stone, group 12-12.........................................................................2.0 ppm

HED continues to recommend that the current tolerance expression for animal commodities be 

changed to reflect both parent and metabolite CGA-304075 (4-[(4-cyclopropyl-6-methyl-2-2-

pyrimidinyl)amino]-phenol).

Residues Used in the Acute and Chronic Analysis

For the acute dietary analysis, tolerance level residues and 100% crop treated assumptions were 

used for all treated commodities. For the chronic dietary analysis, tolerance level residues for 

most commodities; average field trial residues for pome fruit, head lettuce, leaf lettuce, spinach, 

tomato, and grapes; and 100% crop treated assumptions were used. Default processing factors 

were used for most processed commodities, except for tomato paste/puree in the chronic(1x) and 

lemon/lime juice (1x). Residues used in the acute and chronic dietary analysis are provided in 

Table 2. Average residues where noted were used in the chronic dietary analysis.

Table 2. Residue Estimates Used in the Cyprodinil Acute and Chronic Dietary/Drinking Water Analysis

Commodity Tolerance (ppm)

Crop Subgroup 1B, except sugarbeet 0.75

Crop Group 2 10

Onion, bulb subgroup 3-07A 0.6

Onion, green subgroup 3-07B 4.0

Crop Subgroup 4A 

50 tolerance/0.87 avg head lettuce

50 tolerance/13 avg leaf lettuce

50 tolerance/11.8 avg spinach

Crop Subgroup 4B 30

Crop Subgroup 5A Head and stem 1.0

Crop Subgroup 5B Leafy Brassica greens 10

Bean, dry; Bean, succulent 0.6

Vegetable, fruiting, group 8-10 1.5

Crop Group 9 0.7

Lemon, Lime 0.6

Citrus Oil 60

Pome fruit, Crop group 11-10 (B. Cropp-Kohlligian, D378920, 10/27/10)

1.7 tolerance/0.50 avg apple

1.7 tolerance/0.38 avg pear

Stone fruit, Crop group 12 2
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Table 2. Residue Estimates Used in the Cyprodinil Acute and Chronic Dietary/Drinking Water Analysis

Commodity Tolerance (ppm)

Caneberry, subgroup 13-07A 10

Bushberry subgroup 13-07B 3

Small fruit vine climbing subgroup 13-07F, except fuzzy kiwifruit (G. 

Kramer, D247620, 6/14/02)

3.0 tolerance/0.81 avg grapes

Low growing berry subgroup 13-07G, except cranberry 5.0 (inc. strawberry)

Almond 0.02

Pistachio 0.1

Crop Subgroup 19A Herb Fresh (except parsley) 3

Crop Subgroup 19A Herb Dried (except parsley) 15

Parsley, dried leaves 170

Parsley leaves 35

Rape seed oil (canola, seed) 0.03

Avocado, Canistel; Mango; Papaya; Sapodilla; Sapote, black; Sapote, 

mamey; Star apple

1.2

Dragonfruit 2.0

Kiwifruit 1.8

Watercress 20

Beef, Goat, Horse, Sheep, meat byproducts (including liver and kidney ) 0.02

Grape, raisin 5.0

Turnip, greens 10.0

III. Percent Crop Treated Information

The acute and chronic dietary exposure analyses assumed 100% crop treated (CT). 

IV. Drinking Water Data

Drinking water residues were incorporated directly into the acute and chronic dietary analyses as

“water, direct, all sources” and “water, indirect, all sources” and were provided by the 

Environmental Fate and Effects Division (EFED) (D421158, J Melendez 1/12/15). The tier 2 

aquatic models PRZM (Pesticide Root Zone Model)-EXAMS (Exposure Analysis Modeling 

System), and the models Screening Concentration in Ground Water (SCI-GROW) and Pesticide 

Root Zone Model for Groundwater (PRZM-GW) were used to obtain estimated drinking water 

concentrations (EDWCs) in surface water and groundwater, respectively. The acute EDWC in 

surface water is 34.8 μg/L for the total residues of cyprodinil plus CGA-249287. The chronic 

EDWC in surface waters is 24.7 μg/L for the total residues of cyprodinil and CGA-249287. The 

cancer/chronic EDWC in surface waters is 16.4 μg/L for the total residues of cyprodinil and 

CGA-249287. All surface waters EDWCs were obtained using the New York grapes PRZM 

scenario. The PRZM-GW generated EDWC for the use on grapes, using the FL citrus surrogate 

scenario were 2.05 μg/L for the total residues of cyprodinil and CGA-249287 (acute) and 1.80 

μg/L for the total residues (chronic). For details on methods, characterization of results, 

uncertainties, etc., please, refer to the previous DWAs. Table 3 provides a summary of the Tier 2 

modeled drinking water concentrations.
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Table 3. Maximum Estimated Drinking Water Concentrations for the Use of Cyprodinil (expressed as total 

residues of cyprodinil plus its degradate CGA-249287)

DRINKING WATER SOURCE 

(MODEL USED) USE (rate modeled per year)

MAXIMUM ESTIMATED DRINKING WATER 

CONCENTRATION (EDWC) ( ppb)

Groundwater (PRZM-GW) FL citrus1(1.4 lb a.i.) Acute 2.05

Chronic 1.80

Surface water

(PRZM/EXAMS) NY grapes (1.4 lb a.i.)

Acute 34.8

Chronic 24.7

Cancer/Chronic 16.4

1 Scenario was used as a surrogate and run with the maximum application rate for grapes.

V. DEEM-FCID Program and Consumption Information

Cyprodinil acute and chronic dietary exposure assessments were conducted using the Dietary

Exposure Evaluation Model software with the Food Commodity Intake Database DEEM-FCID, 

Version 3.18, which incorporates consumption data from USDA’s National Health and Nutrition 

Examination Survey, What We Eat in America, (NHANES/WWEIA). This dietary survey was 

conducted from 2003 to 2008. The data are based on the reported consumption of more than 

20,000 individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) 

are linked to EPA-defined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; 

baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation 

files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption 

data are averaged for the entire U.S. population and within population subgroups, but for acute 

exposure assessment are retained as individual consumption events. Based on analysis of the 

2003-2008 WWEIA consumption data, which took into account dietary patterns and survey

respondents, HED concluded that it is most appropriate to report risk for the following 

population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, 

children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form. The resulting residue consumption 

estimate for each food/food form is summed with the residue consumption estimates for all other 

food/food forms on the commodity residue list to arrive at the total average estimated exposure. 

Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure 

is performed for each population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or “matched” in multiple random pairings with residue values 

and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aPAD on both a user (i.e., those who reported eating relevant 
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commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 

commodities as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for all tiers of analysis. However, for Tiers 1 and 2, significant 

differences in user vs. per capita exposure and risk are identified and noted in the risk 

assessment.

VI. Toxicological Information

HED evaluated the toxicology data base for cyprodinil and selected doses and endpoints for chronic 

dietary and drinking water risk assessments provided in Table 4. 

Table 4. Summary of Toxicological Doses and Endpoints for Cyprodinil for Use in Dietary Human Health Risk Assessments

Exposure/Scenario Point of 

Departure

Uncertainty/F

QPA Safety 

Factors

RfD, PAD, LOC 

for Risk 

Assessment

Study and Toxicological Effects

Acute Dietary

(All Populations)

NOAEL = 200 

mg/kg/day

UFA= 10x

UFH=10x

FQPA SF= 1x

Acute RfD = 2.0

mg/kg/day 

aPAD = 2.0

mg/kg/day 

Acute Neurotoxicity - Rat

LOAEL = 600 mg/kg/day based on clinical 

signs of toxicity, low motor activity and 

reversible hypothermia

Chronic Dietary 

(All Populations)

NOAEL= 2.7

mg/kg/day

UFA = 10x

UFH =10x

FQPA SF= 1x

Chronic RfD = 

0.027

mg/kg/day

cPAD = 

0.027mg/kg/day

2-Year Chronic Toxicity/ Carcinogenicity- rat

LOAEL = 35.6 mg/kg/day based on 

degenerative liver lesions (spongiosis hepatis) 

in males.

Cancer (all routes) Classification: “Not likely to be carcinogenic to humans”

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and used to mark the beginning of 

extrapolation to determine risk associated with lower environmentally relevant human exposures. 

NOAEL = no observed adverse effect level. 

LOAEL = lowest observed adverse effect level. 

UF = uncertainty factor. 

UFA = extrapolation from animal to human (interspecies). 

UFH = potential variation in sensitivity among members of the human population (intraspecies). 

FQPA SF = FQPA Safety Factor. 

PAD = population adjusted dose (a = acute, c = chronic). 

RfD = reference dose. 

VII. Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 

100% of the PAD. The DEEM-FCIDTM analyses estimate the dietary exposure of the U.S. 

population and various population subgroups. The results reported in Tables 5 & 6 are for the 

general U.S. Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 

13-19, females 13-49, adults 20-49, and adults 50-99 years.
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Results of Acute Dietary Exposure Analysis

The results of the acute dietary exposure analysis are reported in Table 5. 

Table 5: Summary of Acute Dietary Exposure and Risk for Cyprodinil

Population Subgroup aPAD (mg/kg/day) Acute (95th Percentile)

Exposure (mg/kg/day) %aPAD

General U.S. Population

2.0

0.095198 4.8

All Infants (< 1 year old) 0.101588 5.1

Children 1-2 years old 0.172629 8.6

Children 3-5 years old 0.158663 7.9

Children 6-12 years old 0.083374 4.2

Youth 13-19 years old 0.071553 3.6

Adults 20-49 years old 0.091866 4.6

Adults 50+ years old 0.091595 4.6

Females 13-49 years old 0.096706 4.8

The bolded %aPAD is the highest.

Results of Chronic Dietary Exposure Analysis

The results of the chronic dietary exposure analysis are reported in Table 6. 

Table 6: Summary of Chronic Dietary Exposure and Risk for Cyprodinil

Population Subgroup cPAD (mg/kg/day) Chronic

Exposure (mg/kg/day) % cPAD

General U.S. Population

0.027

0.007794 29

All Infants (< 1 year old) 0.013042 48

Children 1-2 years old 0.023045 85

Children 3-5 years old 0.016592 62

Children 6-12 years old 0.008522 32

Youth 13-19 years old 0.004665 17

Adults 20-49 years old 0.006327 23

Adults 50+ years old 0.007772 29

Females 13-49 years old 0.006706 25

The bolded %cPAD is the highest.

VIII. Characterization of Inputs/Outputs

For the acute dietary analysis, tolerance level residues and 100% crop treated assumptions were 

used for all treated commodities. For the chronic dietary analysis, tolerance level residues for 

most commodities; average field trial residues for pome fruit, head lettuce, leaf lettuce, spinach, 

tomatoes, lemon, and grapes; and 100% crop treated assumptions were used. Default processing 

factors were used for all processed commodities except tomato paste/puree (1x) and lemon/lime 

juice (1x). Risk drivers are celery, pome fruit, and strawberry. Residues do not warrant further 

refinement at this time.
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IX. Conclusions

An acute and chronic dietary exposure analyses was performed for the general U.S. population 

and various population subgroups. The acute and chronic risk estimates are below HED’s level 

of concern. HED is confident the acute and chronic dietary exposures to cyprodinil are not 

underestimated.

X. List of Attachments

1. Acute DEEM-FCID Residue Input File.

2. Results of Acute DEEM-FCID Dietary Exposure Analysis.

3. Chronic DEEM-FCID Residue Input File.

4. Results of Chronic DEEM-FCID Dietary Exposure Analysis.
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Attachment 1 Acute DEEM-FCID Residue Input File

Filename: C:\Users\tmorton\Documents\My Files\DEEM Files\288202 Cyprodinil\Cyprodinil 

4E8273\288202ACUTEEPARECOMMENDATIONS PLUS 13-07F CODEX HARM.R08

Chemical: cyprodinil

RfD(Chronic): .03 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): 2 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 04-09-2015/09:37:24 Program ver. 3.16, 03-08-d

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0101050000 1AB Beet, garden, roots 0.750000 1.000 1.000 

0101050001 1AB Beet, garden, roots-babyfood 0.750000 1.000 1.000 

0101067000 1AB Burdock 0.750000 1.000 1.000 

0101078000 1AB Carrot 0.750000 1.000 1.000 

0101078001 1AB Carrot-babyfood 0.750000 1.000 1.000 

0101079000 1AB Carrot, juice 0.750000 1.000 1.000 

0101084000 1AB Celeriac 0.750000 1.000 1.000 

0101100000 1AB Chicory, roots 0.750000 1.000 1.000 

0101168000 1AB Ginseng, dried 0.750000 1.000 1.000 

0101190000 1AB Horseradish 0.750000 1.000 1.000 

0101250000 1AB Parsley, turnip rooted 0.750000 1.000 1.000 

0101251000 1AB Parsnip 0.750000 1.000 1.000 

0101251001 1AB Parsnip-babyfood 0.750000 1.000 1.000 

0101314000 1AB Radish, roots 0.750000 1.000 1.000 

0101316000 1AB Radish, Oriental, roots 0.750000 1.000 1.000 

0101327000 1AB Rutabaga 0.750000 1.000 1.000 

0101331000 1AB Salsify, roots 0.750000 1.000 1.000 

0101388000 1AB Turnip, roots 0.750000 1.000 1.000 

0200051000 2 Beet, garden, tops 10.000000 1.000 1.000 

0200101000 2 Chicory, tops 10.000000 1.000 1.000 

0200140000 2 Dasheen, leaves 10.000000 1.000 1.000 

0200315000 2 Radish, tops 10.000000 1.000 1.000 

0200317000 2 Radish, Oriental, tops 10.000000 1.000 1.000 

0200332000 2 Salsify, tops 10.000000 1.000 1.000 

0301165000 3A Garlic, bulb 0.600000 1.000 1.000 

0301165001 3A Garlic, bulb-babyfood 0.600000 1.000 1.000 

0301237000 3A Onion, bulb 0.600000 1.000 1.000 

0301237001 3A Onion, bulb-babyfood 0.600000 1.000 1.000 

0301238000 3A Onion, bulb, dried 0.600000 9.000 1.000 

0301238001 3A Onion, bulb, dried-babyfood 0.600000 9.000 1.000 

0301338000 3A Shallot, bulb 0.600000 1.000 1.000 

0302103000 3B Chive, fresh leaves 3.000000 1.000 1.000 

0302198000 3B Leek 4.000000 1.000 1.000 

0302239000 3B Onion, green 4.000000 1.000 1.000 

0302338500 3B Shallot, fresh leaves 4.000000 1.000 1.000 

0401005000 4A Amaranth, leafy 50.000000 1.000 1.000 

0401018000 4A Arugula 50.000000 1.000 1.000 

0401104000 4A Chrysanthemum, garland 50.000000 1.000 1.000 

0401133000 4A Cress, garden 50.000000 1.000 1.000 

0401134000 4A Cress, upland 50.000000 1.000 1.000 

0401138000 4A Dandelion, leaves 50.000000 1.000 1.000 

0401150000 4A Endive 50.000000 1.000 1.000 

0401204000 4A Lettuce, head 50.000000 1.000 1.000 

0401205000 4A Lettuce, leaf 50.000000 1.000 1.000 

0401248000 4A Parsley, leaves 50.000000 1.000 1.000 

0401313000 4A Radicchio 50.000000 1.000 1.000 

0401355000 4A Spinach 50.000000 1.000 1.000 

0401355001 4A Spinach-babyfood 50.000000 1.000 1.000 

0402076000 4B Cardoon 30.000000 1.000 1.000 

0402085000 4B Celery 30.000000 1.000 1.000 

0402085001 4B Celery-babyfood 30.000000 1.000 1.000 

0402086000 4B Celery, juice 30.000000 1.000 1.000 

0402087000 4B Celtuce 30.000000 1.000 1.000 

0402152000 4B Fennel, Florence 30.000000 1.000 1.000 

0402322000 4B Rhubarb 30.000000 1.000 1.000 

0402367000 4B Swiss chard 30.000000 1.000 1.000 

0501061000 5A Broccoli 1.000000 1.000 1.000 
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0501061001 5A Broccoli-babyfood 1.000000 1.000 1.000 

0501062000 5A Broccoli, Chinese 1.000000 1.000 1.000 

0501064000 5A Brussels sprouts 1.000000 1.000 1.000 

0501069000 5A Cabbage 1.000000 1.000 1.000 

0501071000 5A Cabbage, Chinese, napa 1.000000 1.000 1.000 

0501072000 5A Cabbage, Chinese, mustard 1.000000 1.000 1.000 

0501083000 5A Cauliflower 1.000000 1.000 1.000 

0501196000 5A Kohlrabi 1.000000 1.000 1.000 

0502063000 5B Broccoli raab 10.000000 1.000 1.000 

0502070000 5B Cabbage, Chinese, bok choy 10.000000 1.000 1.000 

0502117000 5B Collards 10.000000 1.000 1.000 

0502194000 5B Kale 10.000000 1.000 1.000 

0502229000 5B Mustard greens 10.000000 1.000 1.000 

0502318000 5B Rape greens 10.000000 1.000 1.000 

0502389000 5B Turnip, greens 10.000000 1.000 1.000 

0602031000 6B Bean, broad, succulent 0.600000 1.000 1.000 

0602033000 6B Bean, cowpea, succulent 0.600000 1.000 1.000 

0602037000 6B Bean, lima, succulent 0.600000 1.000 1.000 

0603030000 6C Bean, black, seed 0.600000 1.000 1.000 

0603032000 6C Bean, broad, seed 0.600000 1.000 1.000 

0603034000 6C Bean, cowpea, seed 0.600000 1.000 1.000 

0603035000 6C Bean, great northern, seed 0.600000 1.000 1.000 

0603036000 6C Bean, kidney, seed 0.600000 1.000 1.000 

0603038000 6C Bean, lima, seed 0.600000 1.000 1.000 

0603039000 6C Bean, mung, seed 0.600000 1.000 1.000 

0603040000 6C Bean, navy, seed 0.600000 1.000 1.000 

0603041000 6C Bean, pink, seed 0.600000 1.000 1.000 

0603042000 6C Bean, pinto, seed 0.600000 1.000 1.000 

0603098000 6C Chickpea, seed 0.600000 1.000 1.000 

0603098001 6C Chickpea, seed-babyfood 0.600000 1.000 1.000 

0603099000 6C Chickpea, flour 0.600000 1.000 1.000 

0603182000 6C Guar, seed 0.600000 1.000 1.000 

0603182001 6C Guar, seed-babyfood 0.600000 1.000 1.000 

0603203000 6C Lentil, seed 0.600000 1.000 1.000 

0801374000 8A Tomatillo 1.500000 1.000 1.000 

0801375000 8A Tomato 1.500000 1.000 1.000 

0801375001 8A Tomato-babyfood 1.500000 1.000 1.000 

0801376000 8A Tomato, paste 1.500000 1.000 1.000 

0801376001 8A Tomato, paste-babyfood 1.500000 1.000 1.000 

0801377000 8A Tomato, puree 1.500000 1.000 1.000 

0801377001 8A Tomato, puree-babyfood 1.500000 1.000 1.000 

0801378000 8A Tomato, dried 1.500000 14.300 1.000 

0801378001 8A Tomato, dried-babyfood 1.500000 14.300 1.000 

0801379000 8A Tomato, juice 1.500000 1.000 1.000 

0801380000 8A Tomato, Tree 1.500000 1.000 1.000 

0802148000 8BC Eggplant 1.500000 1.000 1.000 

0802234000 8BC Okra 1.500000 1.000 1.000 

0802270000 8B Pepper, bell 1.500000 1.000 1.000 

0802270001 8B Pepper, bell-babyfood 1.500000 1.000 1.000 

0802271000 8B Pepper, bell, dried 1.500000 1.000 1.000 

0802271001 8B Pepper, bell, dried-babyfood 1.500000 1.000 1.000 

0802272000 8BC Pepper, nonbell 1.500000 1.000 1.000 

0802272001 8BC Pepper, nonbell-babyfood 1.500000 1.000 1.000 

0802273000 8BC Pepper, nonbell, dried 1.500000 1.000 1.000 

0901075000 9A Cantaloupe 0.700000 1.000 1.000 

0901187000 9A Honeydew melon 0.700000 1.000 1.000 

0901399000 9A Watermelon 0.700000 1.000 1.000 

0901400000 9A Watermelon, juice 0.700000 1.000 1.000 

0902021000 9B Balsam pear 0.700000 1.000 1.000 

0902088000 9B Chayote, fruit 0.700000 1.000 1.000 

0902102000 9B Chinese waxgourd 0.700000 1.000 1.000 

0902135000 9B Cucumber 0.700000 1.000 1.000 

0902308000 9B Pumpkin 0.700000 1.000 1.000 

0902309000 9B Pumpkin, seed 0.700000 1.000 1.000 

0902356000 9B Squash, summer 0.700000 1.000 1.000 

0902356001 9B Squash, summer-babyfood 0.700000 1.000 1.000 

0902357000 9B Squash, winter 0.700000 1.000 1.000 

0902357001 9B Squash, winter-babyfood 0.700000 1.000 1.000 

1001108000 10A Citrus, oil 60.000000 1.000 1.000 

1002199000 10B Lemon 0.600000 1.000 1.000 
Cyprodinil (PC Code 288202) Dietary Exposure and Risk Assessment DP # 425997: 

Page 12 of 22

1002200000 10B Lemon, juice 0.600000 1.000 1.000 

1002200001 10B Lemon, juice-babyfood 0.600000 1.000 1.000 

1002201000 10B Lemon, peel 0.600000 1.000 1.000 

1002206000 10B Lime 0.600000 1.000 1.000 

1002207000 10B Lime, juice 0.600000 1.000 1.000 

1002207001 10B Lime, juice-babyfood 0.600000 1.000 1.000 

1100007000 11 Apple, fruit with peel 1.700000 1.000 1.000 PP#0F7

 Full comment: PP#0F7696

1100008000 11 Apple, peeled fruit 1.700000 1.000 1.000 PP#0F7

 Full comment: PP#0F7696

1100008001 11 Apple, peeled fruit-babyfood 1.700000 1.000 1.000 PP#0F7

 Full comment: PP#0F7696

1100009000 11 Apple, dried 1.700000 8.000 1.000 PP#0F7

 Full comment: PP#0F7696

1100009001 11 Apple, dried-babyfood 1.700000 8.000 1.000 PP#0F7

 Full comment: PP#0F7696

1100010000 11 Apple, juice 1.700000 1.300 1.000 PP#0F7

 Full comment: PP#0F7696

1100010001 11 Apple, juice-babyfood 1.700000 1.300 1.000 PP#0F7

 Full comment: PP#0F7696

1100011000 11 Apple, sauce 1.700000 1.000 1.000 PP#0F7

 Full comment: PP#0F7696

1100011001 11 Apple, sauce-babyfood 1.700000 1.000 1.000 PP#0F7

 Full comment: PP#0F7696

1100129000 11 Crabapple 1.700000 1.000 1.000 PP#0F7

 Full comment: PP#0F7696

1100173500 11 Goji berry 1.500000 1.000 1.000 

1100210000 11 Loquat 1.700000 1.000 1.000 PP#0F7

 Full comment: PP#0F7696

1100266000 11 Pear 1.700000 1.000 1.000 PP#0F7

 Full comment: PP#0F7696

1100266001 11 Pear-babyfood 1.700000 1.000 1.000 PP#0F7

 Full comment: PP#0F7696

1100267000 11 Pear, dried 1.700000 6.250 1.000 PP#0F7

 Full comment: PP#0F7696

1100268000 11 Pear, juice 1.700000 1.000 1.000 PP#0F7

 Full comment: PP#0F7696

1100268001 11 Pear, juice-babyfood 1.700000 1.000 1.000 PP#0F7

 Full comment: PP#0F7696

1100310000 11 Quince 1.700000 1.000 1.000 PP#0F7

 Full comment: PP#0F7696

1201090000 12A Cherry 2.000000 1.000 1.000 

1201090001 12A Cherry-babyfood 2.000000 1.000 1.000 

1201091000 12A Cherry, juice 2.000000 1.500 1.000 

1201091001 12A Cherry, juice-babyfood 2.000000 1.500 1.000 

1202012000 12B Apricot 2.000000 1.000 1.000 

1202012001 12B Apricot-babyfood 2.000000 1.000 1.000 

1202013000 12B Apricot, dried 2.000000 6.000 1.000 

1202014000 12B Apricot, juice 2.000000 1.000 1.000 

1202014001 12B Apricot, juice-babyfood 2.000000 1.000 1.000 

1202230000 12B Nectarine 2.000000 1.000 1.000 

1202260000 12B Peach 2.000000 1.000 1.000 

1202260001 12B Peach-babyfood 2.000000 1.000 1.000 

1202261000 12B Peach, dried 2.000000 7.000 1.000 

1202261001 12B Peach, dried-babyfood 2.000000 7.000 1.000 

1202262000 12B Peach, juice 2.000000 1.000 1.000 

1202262001 12B Peach, juice-babyfood 2.000000 1.000 1.000 

1203285000 12C Plum 2.000000 1.000 1.000 

1203285001 12C Plum-babyfood 2.000000 1.000 1.000 

1203286000 12C Plum, prune, fresh 2.000000 1.000 1.000 

1203286001 12C Plum, prune, fresh-babyfood 2.000000 1.000 1.000 

1203287000 12C Plum, prune, dried 2.000000 5.000 1.000 

1203287001 12C Plum, prune, dried-babyfood 2.000000 5.000 1.000 

1203288000 12C Plum, prune, juice 2.000000 1.400 1.000 

1203288001 12C Plum, prune, juice-babyfood 2.000000 1.400 1.000 

1301055000 13A Blackberry 10.000000 1.000 1.000 

1301056000 13A Blackberry, juice 10.000000 1.000 1.000 

1301056001 13A Blackberry, juice-babyfood 10.000000 1.000 1.000 

1301058000 13A Boysenberry 10.000000 1.000 1.000 

1301208000 13A Loganberry 10.000000 1.000 1.000 
Cyprodinil (PC Code 288202) Dietary Exposure and Risk Assessment DP # 425997: 

Page 13 of 22

1301320000 13A Raspberry 10.000000 1.000 1.000 

1301320001 13A Raspberry-babyfood 10.000000 1.000 1.000 

1301321000 13A Raspberry, juice 10.000000 1.000 1.000 

1301321001 13A Raspberry, juice-babyfood 10.000000 1.000 1.000 

1302057000 13B Blueberry 3.000000 1.000 1.000 

1302057001 13B Blueberry-babyfood 3.000000 1.000 1.000 

1302136000 13B Currant 3.000000 1.000 1.000 

1302137000 13B Currant, dried 3.000000 1.000 1.000 

1302149000 13B Elderberry 3.000000 1.000 1.000 

1302174000 13B Gooseberry 3.000000 1.000 1.000 

1302191000 13B Huckleberry 3.000000 1.000 1.000 

1304175000 13D Grape 3.000000 1.000 1.000 

1304176000 13D Grape, juice 3.000000 1.200 1.000 

1304176001 13D Grape, juice-babyfood 3.000000 1.200 1.000 

1304179000 13D Grape, wine and sherry 3.000000 1.000 1.000 

1304195000 13D Kiwifruit, fuzzy 1.800000 1.000 1.000 

1307359000 13G Strawberry 5.000000 1.000 1.000 

1307359001 13G Strawberry-babyfood 5.000000 1.000 1.000 

1307360000 13G Strawberry, juice 5.000000 1.000 1.000 

1307360001 13G Strawberry, juice-babyfood 5.000000 1.000 1.000 

1400003000 14 Almond 0.020000 1.000 1.000 

1400003001 14 Almond-babyfood 0.020000 1.000 1.000 

1400004000 14 Almond, oil 0.020000 1.000 1.000 

1400004001 14 Almond, oil-babyfood 0.020000 1.000 1.000 

1400282000 14 Pistachio 0.100000 1.000 1.000 

1901028000 19A Basil, fresh leaves 3.000000 1.000 1.000 

1901028001 19A Basil, fresh leaves-babyfood 3.000000 1.000 1.000 

1901029000 19A Basil, dried leaves 15.000000 1.000 1.000 

1901029001 19A Basil, dried leaves-babyfood 15.000000 1.000 1.000 

1901102500 19A Chive, dried leaves 15.000000 1.000 1.000 

1901118000 19A Cilantro, leaves 3.000000 1.000 1.000 

1901118001 19A Cilantro, leaves-babyfood 3.000000 1.000 1.000 

1901144000 19A Dillweed 3.000000 1.000 1.000 

1901184000 19A Herbs, other 3.000000 1.000 1.000 

1901184001 19A Herbs, other-babyfood 3.000000 1.000 1.000 

1901202000 19A Lemongrass 3.000000 1.000 1.000 

1901220000 19A Marjoram 3.000000 1.000 1.000 

1901220001 19A Marjoram-babyfood 3.000000 1.000 1.000 

1901249000 19A Parsley, dried leaves 170.000000 1.000 1.000 

1901249001 19A Parsley, dried leaves-babyfood 170.000000 1.000 1.000 

1901334000 19A Savory 3.000000 1.000 1.000 

2001319000 20A Rapeseed, oil 0.030000 1.000 1.000 

2001319001 20A Rapeseed, oil-babyfood 0.030000 1.000 1.000 

3100046000 31 Beef, meat byproducts 0.020000 1.000 1.000 

3100046001 31 Beef, meat byproducts-babyfood 0.020000 1.000 1.000 

3100048000 31 Beef, kidney 0.020000 1.000 1.000 

3100049000 31 Beef, liver 0.020000 1.000 1.000 

3100049001 31 Beef, liver-babyfood 0.020000 1.000 1.000 

3200170000 32 Goat, meat byproducts 0.020000 1.000 1.000 

3200172000 32 Goat, kidney 0.020000 1.000 1.000 

3200173000 32 Goat, liver 0.020000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 0.020000 1.000 1.000 

3500342000 35 Sheep, kidney 0.020000 1.000 1.000 

3500343000 35 Sheep, liver 0.020000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.034790 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.034790 1.000 1.000 

9500001000 O Acerola 1.500000 1.000 1.000 

9500016000 O Artichoke, globe 4.000000 1.000 1.000 

9500020000 O Avocado 1.200000 1.000 1.000 

9500074000 O Canistel 1.200000 1.000 1.000 

9500151000 O Feijoa 1.500000 1.000 1.000 

9500177000 O Grape, leaves 3.000000 1.000 1.000 

9500178000 O Grape, raisin 5.000000 1.000 1.000 

9500183000 O Guava 1.500000 1.000 1.000 

9500183001 O Guava-babyfood 1.500000 1.000 1.000 

9500209000 O Longan 2.000000 1.000 1.000 

9500211000 O Lychee 2.000000 1.000 1.000 

9500212000 O Lychee, dried 2.000000 1.850 1.000 

9500215000 O Mango 1.200000 1.000 1.000 

9500215001 O Mango-babyfood 1.200000 1.000 1.000 
Cyprodinil (PC Code 288202) Dietary Exposure and Risk Assessment DP # 425997: 

Page 14 of 22

9500216000 O Mango, dried 1.200000 1.000 1.000 

9500217000 O Mango, juice 1.200000 1.000 1.000 

9500217001 O Mango, juice-babyfood 1.200000 1.000 1.000 

9500245000 O Papaya 1.200000 1.000 1.000 

9500245001 O Papaya-babyfood 1.200000 1.000 1.000 

9500246000 O Papaya, dried 1.200000 1.800 1.000 

9500247000 O Papaya, juice 1.200000 1.500 1.000 

9500252000 O Passionfruit 1.500000 1.000 1.000 

9500252001 O Passionfruit-babyfood 1.500000 1.000 1.000 

9500253000 O Passionfruit, juice 1.500000 1.000 1.000 

9500253001 O Passionfruit, juice-babyfood 1.500000 1.000 1.000 

9500289000 O Pomegranate 10.000000 1.000 1.000 

9500333000 O Sapote, Mamey 1.200000 1.000 1.000 

9500351000 O Spanish lime 2.000000 1.000 1.000 

9500358000 O Starfruit 1.500000 1.000 1.000 

9500398000 O Watercress 20.000000 1.000 1.000 
Cyprodinil (PC Code 288202) Dietary Exposure and Risk Assessment DP # 425997: 

Page 15 of 22

Attachment 2 Chronic DEEM-FCID Residue Input File

Filename: C:\Users\tmorton\Documents\My Files\DEEM Files\288202 Cyprodinil\Cyprodinil 

4E8273\288202CHRONICEPARECOMMENDATIONS.R08

Chemical: cyprodinil

RfD(Chronic): .03 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): 1.5 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 04-09-2015/09:10:28 Program ver. 3.16, 03-08-d

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0101050000 1AB Beet, garden, roots 0.750000 1.000 1.000 

0101050001 1AB Beet, garden, roots-babyfood 0.750000 1.000 1.000 

0101067000 1AB Burdock 0.750000 1.000 1.000 

0101078000 1AB Carrot 0.750000 1.000 1.000 

0101078001 1AB Carrot-babyfood 0.750000 1.000 1.000 

0101079000 1AB Carrot, juice 0.750000 1.000 1.000 

0101084000 1AB Celeriac 0.750000 1.000 1.000 

0101100000 1AB Chicory, roots 0.750000 1.000 1.000 

0101168000 1AB Ginseng, dried 0.750000 1.000 1.000 

0101190000 1AB Horseradish 0.750000 1.000 1.000 

0101250000 1AB Parsley, turnip rooted 0.750000 1.000 1.000 

0101251000 1AB Parsnip 0.750000 1.000 1.000 

0101251001 1AB Parsnip-babyfood 0.750000 1.000 1.000 

0101314000 1AB Radish, roots 0.750000 1.000 1.000 

0101316000 1AB Radish, Oriental, roots 0.750000 1.000 1.000 

0101327000 1AB Rutabaga 0.750000 1.000 1.000 

0101331000 1AB Salsify, roots 0.750000 1.000 1.000 

0101388000 1AB Turnip, roots 0.750000 1.000 1.000 

0200051000 2 Beet, garden, tops 10.000000 1.000 1.000 

0200101000 2 Chicory, tops 10.000000 1.000 1.000 

0200140000 2 Dasheen, leaves 10.000000 1.000 1.000 

0200315000 2 Radish, tops 10.000000 1.000 1.000 

0200317000 2 Radish, Oriental, tops 10.000000 1.000 1.000 

0200332000 2 Salsify, tops 10.000000 1.000 1.000 

0301165000 3A Garlic, bulb 0.600000 1.000 1.000 

0301165001 3A Garlic, bulb-babyfood 0.600000 1.000 1.000 

0301237000 3A Onion, bulb 0.600000 1.000 1.000 

0301237001 3A Onion, bulb-babyfood 0.600000 1.000 1.000 

0301238000 3A Onion, bulb, dried 0.600000 9.000 1.000 

0301238001 3A Onion, bulb, dried-babyfood 0.600000 9.000 1.000 

0301338000 3A Shallot, bulb 0.600000 1.000 1.000 

0302103000 3B Chive, fresh leaves 3.000000 1.000 1.000 

0302198000 3B Leek 4.000000 1.000 1.000 

0302239000 3B Onion, green 4.000000 1.000 1.000 

0302338500 3B Shallot, fresh leaves 4.000000 1.000 1.000 

0401005000 4A Amaranth, leafy 50.000000 1.000 1.000 

0401018000 4A Arugula 50.000000 1.000 1.000 

0401104000 4A Chrysanthemum, garland 50.000000 1.000 1.000 

0401133000 4A Cress, garden 50.000000 1.000 1.000 

0401134000 4A Cress, upland 50.000000 1.000 1.000 

0401138000 4A Dandelion, leaves 50.000000 1.000 1.000 

0401150000 4A Endive 50.000000 1.000 1.000 

0401204000 4A Lettuce, head 0.870000 1.000 1.000 

0401205000 4A Lettuce, leaf 13.000000 1.000 1.000 

0401248000 4A Parsley, leaves 35.000000 1.000 1.000 

0401313000 4A Radicchio 50.000000 1.000 1.000 

0401355000 4A Spinach 11.800000 1.000 1.000 

0401355001 4A Spinach-babyfood 11.800000 1.000 1.000 

0402076000 4B Cardoon 30.000000 1.000 1.000 

0402085000 4B Celery 30.000000 1.000 1.000 

0402085001 4B Celery-babyfood 30.000000 1.000 1.000 

0402086000 4B Celery, juice 30.000000 1.000 1.000 

0402087000 4B Celtuce 30.000000 1.000 1.000 

0402152000 4B Fennel, Florence 30.000000 1.000 1.000 

0402322000 4B Rhubarb 30.000000 1.000 1.000 

0402367000 4B Swiss chard 30.000000 1.000 1.000 

0501061000 5A Broccoli 1.000000 1.000 1.000 
Cyprodinil (PC Code 288202) Dietary Exposure and Risk Assessment DP # 425997: 

Page 16 of 22

0501061001 5A Broccoli-babyfood 1.000000 1.000 1.000 

0501062000 5A Broccoli, Chinese 1.000000 1.000 1.000 

0501064000 5A Brussels sprouts 1.000000 1.000 1.000 

0501069000 5A Cabbage 1.000000 1.000 1.000 

0501071000 5A Cabbage, Chinese, napa 1.000000 1.000 1.000 

0501072000 5A Cabbage, Chinese, mustard 1.000000 1.000 1.000 

0501083000 5A Cauliflower 1.000000 1.000 1.000 

0501196000 5A Kohlrabi 1.000000 1.000 1.000 

0502063000 5B Broccoli raab 10.000000 1.000 1.000 

0502070000 5B Cabbage, Chinese, bok choy 10.000000 1.000 1.000 

0502117000 5B Collards 10.000000 1.000 1.000 

0502194000 5B Kale 10.000000 1.000 1.000 

0502229000 5B Mustard greens 10.000000 1.000 1.000 

0502318000 5B Rape greens 10.000000 1.000 1.000 

0502389000 5B Turnip, greens 10.000000 1.000 1.000 

0602031000 6B Bean, broad, succulent 0.600000 1.000 1.000 

0602033000 6B Bean, cowpea, succulent 0.600000 1.000 1.000 

0602037000 6B Bean, lima, succulent 0.600000 1.000 1.000 

0603030000 6C Bean, black, seed 0.600000 1.000 1.000 

0603032000 6C Bean, broad, seed 0.600000 1.000 1.000 

0603034000 6C Bean, cowpea, seed 0.600000 1.000 1.000 

0603035000 6C Bean, great northern, seed 0.600000 1.000 1.000 

0603036000 6C Bean, kidney, seed 0.600000 1.000 1.000 

0603038000 6C Bean, lima, seed 0.600000 1.000 1.000 

0603039000 6C Bean, mung, seed 0.600000 1.000 1.000 

0603040000 6C Bean, navy, seed 0.600000 1.000 1.000 

0603041000 6C Bean, pink, seed 0.600000 1.000 1.000 

0603042000 6C Bean, pinto, seed 0.600000 1.000 1.000 

0603098000 6C Chickpea, seed 0.600000 1.000 1.000 

0603098001 6C Chickpea, seed-babyfood 0.600000 1.000 1.000 

0603099000 6C Chickpea, flour 0.600000 1.000 1.000 

0603182000 6C Guar, seed 0.600000 1.000 1.000 

0603182001 6C Guar, seed-babyfood 0.600000 1.000 1.000 

0603203000 6C Lentil, seed 0.600000 1.000 1.000 

0801374000 8A Tomatillo 0.160000 1.000 1.000 

0801375000 8A Tomato 0.160000 1.000 1.000 

0801375001 8A Tomato-babyfood 0.160000 1.000 1.000 

0801376000 8A Tomato, paste 0.160000 1.000 1.000 

0801376001 8A Tomato, paste-babyfood 0.160000 1.000 1.000 

0801377000 8A Tomato, puree 0.160000 1.000 1.000 

0801377001 8A Tomato, puree-babyfood 0.160000 1.000 1.000 

0801378000 8A Tomato, dried 0.160000 14.300 1.000 

0801378001 8A Tomato, dried-babyfood 0.160000 14.300 1.000 

0801379000 8A Tomato, juice 0.160000 1.000 1.000 

0801380000 8A Tomato, Tree 0.160000 1.000 1.000 

0802148000 8BC Eggplant 1.500000 1.000 1.000 

0802234000 8BC Okra 1.500000 1.000 1.000 

0802270000 8B Pepper, bell 1.500000 1.000 1.000 

0802270001 8B Pepper, bell-babyfood 1.500000 1.000 1.000 

0802271000 8B Pepper, bell, dried 1.500000 1.000 1.000 

0802271001 8B Pepper, bell, dried-babyfood 1.500000 1.000 1.000 

0802272000 8BC Pepper, nonbell 1.500000 1.000 1.000 

0802272001 8BC Pepper, nonbell-babyfood 1.500000 1.000 1.000 

0802273000 8BC Pepper, nonbell, dried 1.500000 1.000 1.000 

0901075000 9A Cantaloupe 0.700000 1.000 1.000 

0901187000 9A Honeydew melon 0.700000 1.000 1.000 

0901399000 9A Watermelon 0.700000 1.000 1.000 

0901400000 9A Watermelon, juice 0.700000 1.000 1.000 

0902021000 9B Balsam pear 0.700000 1.000 1.000 

0902088000 9B Chayote, fruit 0.700000 1.000 1.000 

0902102000 9B Chinese waxgourd 0.700000 1.000 1.000 

0902135000 9B Cucumber 0.700000 1.000 1.000 

0902308000 9B Pumpkin 0.700000 1.000 1.000 

0902309000 9B Pumpkin, seed 0.700000 1.000 1.000 

0902356000 9B Squash, summer 0.700000 1.000 1.000 

0902356001 9B Squash, summer-babyfood 0.700000 1.000 1.000 

0902357000 9B Squash, winter 0.700000 1.000 1.000 

0902357001 9B Squash, winter-babyfood 0.700000 1.000 1.000 

1001108000 10A Citrus, oil 60.000000 1.000 1.000 

1002199000 10B Lemon 0.260000 1.000 1.000 
Cyprodinil (PC Code 288202) Dietary Exposure and Risk Assessment DP # 425997: 

Page 17 of 22

1002200000 10B Lemon, juice 0.260000 1.000 1.000 

1002200001 10B Lemon, juice-babyfood 0.260000 1.000 1.000 

1002201000 10B Lemon, peel 0.260000 1.000 1.000 

1002206000 10B Lime 0.260000 1.000 1.000 

1002207000 10B Lime, juice 0.260000 1.000 1.000 

1002207001 10B Lime, juice-babyfood 0.260000 1.000 1.000 

1100007000 11 Apple, fruit with peel 0.500000 1.000 1.000 PP#0F7

 Full comment: PP#0F7696

1100008000 11 Apple, peeled fruit 0.500000 1.000 1.000 PP#0F7

 Full comment: PP#0F7696

1100008001 11 Apple, peeled fruit-babyfood 0.500000 1.000 1.000 PP#0F7

 Full comment: PP#0F7696

1100009000 11 Apple, dried 0.500000 8.000 1.000 PP#0F7

 Full comment: PP#0F7696

1100009001 11 Apple, dried-babyfood 0.500000 8.000 1.000 PP#0F7

 Full comment: PP#0F7696

1100010000 11 Apple, juice 0.500000 1.300 1.000 PP#0F7

 Full comment: PP#0F7696

1100010001 11 Apple, juice-babyfood 0.500000 1.300 1.000 PP#0F7

 Full comment: PP#0F7696

1100011000 11 Apple, sauce 0.500000 1.000 1.000 PP#0F7

 Full comment: PP#0F7696

1100011001 11 Apple, sauce-babyfood 0.500000 1.000 1.000 PP#0F7

 Full comment: PP#0F7696

1100129000 11 Crabapple 0.500000 1.000 1.000 PP#0F7

 Full comment: PP#0F7696

1100173500 11 Goji berry 1.500000 1.000 1.000 

1100210000 11 Loquat 0.500000 1.000 1.000 PP#0F7

 Full comment: PP#0F7696

1100266000 11 Pear 0.380000 1.000 1.000 PP#0F7

 Full comment: PP#0F7696

1100266001 11 Pear-babyfood 0.380000 1.000 1.000 PP#0F7

 Full comment: PP#0F7696

1100267000 11 Pear, dried 0.380000 6.250 1.000 PP#0F7

 Full comment: PP#0F7696

1100268000 11 Pear, juice 0.380000 1.000 1.000 PP#0F7

 Full comment: PP#0F7696

1100268001 11 Pear, juice-babyfood 0.380000 1.000 1.000 PP#0F7

 Full comment: PP#0F7696

1100310000 11 Quince 0.500000 1.000 1.000 PP#0F7

 Full comment: PP#0F7696

1201090000 12A Cherry 2.000000 1.000 1.000 

1201090001 12A Cherry-babyfood 2.000000 1.000 1.000 

1201091000 12A Cherry, juice 2.000000 1.500 1.000 

1201091001 12A Cherry, juice-babyfood 2.000000 1.500 1.000 

1202012000 12B Apricot 2.000000 1.000 1.000 

1202012001 12B Apricot-babyfood 2.000000 1.000 1.000 

1202013000 12B Apricot, dried 2.000000 6.000 1.000 

1202014000 12B Apricot, juice 2.000000 1.000 1.000 

1202014001 12B Apricot, juice-babyfood 2.000000 1.000 1.000 

1202230000 12B Nectarine 2.000000 1.000 1.000 

1202260000 12B Peach 2.000000 1.000 1.000 

1202260001 12B Peach-babyfood 2.000000 1.000 1.000 

1202261000 12B Peach, dried 2.000000 7.000 1.000 

1202261001 12B Peach, dried-babyfood 2.000000 7.000 1.000 

1202262000 12B Peach, juice 2.000000 1.000 1.000 

1202262001 12B Peach, juice-babyfood 2.000000 1.000 1.000 

1203285000 12C Plum 2.000000 1.000 1.000 

1203285001 12C Plum-babyfood 2.000000 1.000 1.000 

1203286000 12C Plum, prune, fresh 2.000000 1.000 1.000 

1203286001 12C Plum, prune, fresh-babyfood 2.000000 1.000 1.000 

1203287000 12C Plum, prune, dried 2.000000 5.000 1.000 

1203287001 12C Plum, prune, dried-babyfood 2.000000 5.000 1.000 

1203288000 12C Plum, prune, juice 2.000000 1.400 1.000 

1203288001 12C Plum, prune, juice-babyfood 2.000000 1.400 1.000 

1301055000 13A Blackberry 10.000000 1.000 1.000 

1301056000 13A Blackberry, juice 10.000000 1.000 1.000 

1301056001 13A Blackberry, juice-babyfood 10.000000 1.000 1.000 

1301058000 13A Boysenberry 10.000000 1.000 1.000 

1301208000 13A Loganberry 10.000000 1.000 1.000 
Cyprodinil (PC Code 288202) Dietary Exposure and Risk Assessment DP # 425997: 

Page 18 of 22

1301320000 13A Raspberry 10.000000 1.000 1.000 

1301320001 13A Raspberry-babyfood 10.000000 1.000 1.000 

1301321000 13A Raspberry, juice 10.000000 1.000 1.000 

1301321001 13A Raspberry, juice-babyfood 10.000000 1.000 1.000 

1302057000 13B Blueberry 3.000000 1.000 1.000 

1302057001 13B Blueberry-babyfood 3.000000 1.000 1.000 

1302136000 13B Currant 3.000000 1.000 1.000 

1302137000 13B Currant, dried 3.000000 1.000 1.000 

1302149000 13B Elderberry 3.000000 1.000 1.000 

1302174000 13B Gooseberry 3.000000 1.000 1.000 

1302191000 13B Huckleberry 3.000000 1.000 1.000 

1304175000 13D Grape 0.810000 1.000 1.000 

1304176000 13D Grape, juice 0.810000 1.200 1.000 

1304176001 13D Grape, juice-babyfood 0.810000 1.200 1.000 

1304179000 13D Grape, wine and sherry 0.810000 1.000 1.000 

1304195000 13D Kiwifruit, fuzzy 1.800000 1.000 1.000 

1307359000 13G Strawberry 5.000000 1.000 1.000 

1307359001 13G Strawberry-babyfood 5.000000 1.000 1.000 

1307360000 13G Strawberry, juice 5.000000 1.000 1.000 

1307360001 13G Strawberry, juice-babyfood 5.000000 1.000 1.000 

1400003000 14 Almond 0.020000 1.000 1.000 

1400003001 14 Almond-babyfood 0.020000 1.000 1.000 

1400004000 14 Almond, oil 0.020000 1.000 1.000 

1400004001 14 Almond, oil-babyfood 0.020000 1.000 1.000 

1400282000 14 Pistachio 0.100000 1.000 1.000 

1901028000 19A Basil, fresh leaves 3.000000 1.000 1.000 

1901028001 19A Basil, fresh leaves-babyfood 3.000000 1.000 1.000 

1901029000 19A Basil, dried leaves 15.000000 1.000 1.000 

1901029001 19A Basil, dried leaves-babyfood 15.000000 1.000 1.000 

1901102500 19A Chive, dried leaves 15.000000 1.000 1.000 

1901118000 19A Cilantro, leaves 3.000000 1.000 1.000 

1901118001 19A Cilantro, leaves-babyfood 3.000000 1.000 1.000 

1901144000 19A Dillweed 3.000000 1.000 1.000 

1901184000 19A Herbs, other 3.000000 1.000 1.000 

1901184001 19A Herbs, other-babyfood 3.000000 1.000 1.000 

1901202000 19A Lemongrass 3.000000 1.000 1.000 

1901220000 19A Marjoram 3.000000 1.000 1.000 

1901220001 19A Marjoram-babyfood 3.000000 1.000 1.000 

1901249000 19A Parsley, dried leaves 170.000000 1.000 1.000 

1901249001 19A Parsley, dried leaves-babyfood 170.000000 1.000 1.000 

1901334000 19A Savory 3.000000 1.000 1.000 

2001319000 20A Rapeseed, oil 0.030000 1.000 1.000 

2001319001 20A Rapeseed, oil-babyfood 0.030000 1.000 1.000 

3100046000 31 Beef, meat byproducts 0.020000 1.000 1.000 

3100046001 31 Beef, meat byproducts-babyfood 0.020000 1.000 1.000 

3100048000 31 Beef, kidney 0.020000 1.000 1.000 

3100049000 31 Beef, liver 0.020000 1.000 1.000 

3100049001 31 Beef, liver-babyfood 0.020000 1.000 1.000 

3200170000 32 Goat, meat byproducts 0.020000 1.000 1.000 

3200172000 32 Goat, kidney 0.020000 1.000 1.000 

3200173000 32 Goat, liver 0.020000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 0.020000 1.000 1.000 

3500342000 35 Sheep, kidney 0.020000 1.000 1.000 

3500343000 35 Sheep, liver 0.020000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.024650 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.024650 1.000 1.000 

9500001000 O Acerola 1.500000 1.000 1.000 

9500016000 O Artichoke, globe 4.000000 1.000 1.000 

9500020000 O Avocado 1.200000 1.000 1.000 

9500074000 O Canistel 1.200000 1.000 1.000 

9500151000 O Feijoa 1.500000 1.000 1.000 

9500177000 O Grape, leaves 0.810000 1.000 1.000 

9500178000 O Grape, raisin 5.000000 1.000 1.000 

9500183000 O Guava 1.500000 1.000 1.000 

9500183001 O Guava-babyfood 1.500000 1.000 1.000 

9500209000 O Longan 2.000000 1.000 1.000 

9500211000 O Lychee 2.000000 1.000 1.000 

9500212000 O Lychee, dried 2.000000 1.850 1.000 

9500215000 O Mango 1.200000 1.000 1.000 

9500215001 O Mango-babyfood 1.200000 1.000 1.000 
Cyprodinil (PC Code 288202) Dietary Exposure and Risk Assessment DP # 425997: 

Page 19 of 22

9500216000 O Mango, dried 1.200000 1.000 1.000 

9500217000 O Mango, juice 1.200000 1.000 1.000 

9500217001 O Mango, juice-babyfood 1.200000 1.000 1.000 

9500245000 O Papaya 1.200000 1.000 1.000 

9500245001 O Papaya-babyfood 1.200000 1.000 1.000 

9500246000 O Papaya, dried 1.200000 1.800 1.000 

9500247000 O Papaya, juice 1.200000 1.500 1.000 

9500252000 O Passionfruit 1.500000 1.000 1.000 

9500252001 O Passionfruit-babyfood 1.500000 1.000 1.000 

9500253000 O Passionfruit, juice 1.500000 1.000 1.000 

9500253001 O Passionfruit, juice-babyfood 1.500000 1.000 1.000 

9500289000 O Pomegranate 10.000000 1.000 1.000 

9500333000 O Sapote, Mamey 1.200000 1.000 1.000 

9500351000 O Spanish lime 2.000000 1.000 1.000 

9500358000 O Starfruit 1.500000 1.000 1.000 

9500398000 O Watercress 20.000000 1.000 1.000 
Cyprodinil (PC Code 288202) Dietary Exposure and Risk Assessment DP # 425997: 

Page 20 of 22

Attachment 3 Results of Acute DEEM-FCID Dietary Exposure Analysis

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for CYPRODINIL NHANES 2003-2008 2-Day

Residue file: 288202 Acute Food and Water.R08 Adjustment factor #2 NOT used.

Analysis Date: 04-09-2015/09:51:29 Residue file dated: 04-09-2015/09:44:19

RAC/FF intake summed over 24 hours

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.095198 4.76 0.181584 9.08 0.310238 15.51 

All Infants:

 0.101588 5.08 0.168263 8.41 0.529152 26.46 

Children 1-2:

 0.172629 8.63 0.277215 13.86 0.443582 22.18 

Children 3-5:

 0.158663 7.93 0.253670 12.68 0.412075 20.60 

Children 6-12:

 0.083374 4.17 0.178317 8.92 0.276162 13.81 

Youth 13-19:

 0.071553 3.58 0.141338 7.07 0.295995 14.80 

Adults 20-49:

 0.091866 4.59 0.182137 9.11 0.314326 15.72 

Adults 50-99:

 0.091595 4.58 0.154312 7.72 0.272418 13.62 

Female 13-49:

 0.096706 4.84 0.187550 9.38 0.327236 16.36 

 

FOOD ONLY

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for CYPRODINIL NHANES 2003-2008 2-Day

Residue file: 288202 Acute Food Only.R08 Adjustment factor #2 NOT used.

Analysis Date: 04-09-2015/09:54:10 Residue file dated: 04-09-2015/09:46:11

RAC/FF intake summed over 24 hours

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.094428 4.72 0.179943 9.00 0.309314 15.47 

All Infants:

 0.099629 4.98 0.167443 8.37 0.528808 26.44 

Children 1-2:

 0.172240 8.61 0.275992 13.80 0.445942 22.30 

Children 3-5:

 0.157732 7.89 0.254669 12.73 0.408825 20.44

Children 6-12:

 0.082435 4.12 0.177091 8.85 0.274520 13.73 

Youth 13-19:

 0.071135 3.56 0.139976 7.00 0.295949 14.80 

Adults 20-49:

 0.091013 4.55 0.180252 9.01 0.312594 15.63 

Adults 50-99:

 0.090599 4.53 0.153660 7.68 0.270453 13.52 

Female 13-49:

 0.095958 4.80 0.187084 9.35 0.325861 16.29 
Cyprodinil (PC Code 288202) Dietary Exposure and Risk Assessment DP # 425997: 

Page 21 of 22

 

Attachment 4 Results of Chronic DEEM-FCID Dietary Exposure Analysis

US EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for CYPRODINIL NHANES 2003-2008 2-day

Residue file name: C:\Users\tmorton\Documents\My Files\DEEM Files\288202 Cyprodinil\Cyprodinil 

4E8273\288202 Chronic Food and Water.R08

 Adjustment factor #2 used.

Analysis Date 04-09-2015/09:48:31 Residue file dated: 04-09-2015/09:43:22

Reference dose (RfD, Chronic) = .027 mg/kg bw/day

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.007794 28.9%

Hispanic 0.007303 27.0%

Non-Hisp-White 0.008032 29.7%

Non-Hisp-Black 0.006325 23.4%

Non-Hisp-Other 0.009383 34.8%

Nursing Infants 0.008687 32.2%

Non-Nursing Infants 0.014986 55.5%

Female 13+ PREG 0.006602 24.5%

Children 1-6 0.018324 67.9%

Children 7-12 0.007696 28.5%

Male 13-19 0.004191 15.5%

Female 13-19/NP 0.005153 19.1%

Male 20+ 0.006066 22.5%

Female 20+/NP 0.007731 28.6%

Seniors 55+ 0.007840 29.0%

All Infants 0.013042 48.3%

Female 13-50 0.006754 25.0%

Children 1-2 0.023045 85.4%

Children 3-5 0.016592 61.5%

Children 6-12 0.008522 31.6%

Youth 13-19 0.004665 17.3%

Adults 20-49 0.006327 23.4%

Adults 50-99 0.007772 28.8%

Female 13-49 0.006706 24.8%

-------------------------------------------------------------------------------
Cyprodinil (PC Code 288202) Dietary Exposure and Risk Assessment DP # 425997: 

Page 22 of 22

FOOD ONLY

US EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for CYPRODINIL NHANES 2003-2008 2-day

Residue file name: C:\Users\tmorton\Documents\My Files\DEEM Files\288202 Cyprodinil\Cyprodinil 

4E8273\288202 Chronic Food Only.R08

 Adjustment factor #2 used.

Analysis Date 04-09-2015/09:49:01 Residue file dated: 04-09-2015/09:47:27

Reference dose (RfD, Chronic) = .027 mg/kg bw/day

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.007277 27.0%

Hispanic 0.006810 25.2%

Non-Hisp-White 0.007501 27.8%

Non-Hisp-Black 0.005899 21.8%

Non-Hisp-Other 0.008788 32.5%

Nursing Infants 0.008220 30.4%

Non-Nursing Infants 0.013270 49.1%

Female 13+ PREG 0.006116 22.7%

Children 1-6 0.017663 65.4%

Children 7-12 0.007266 26.9%

Male 13-19 0.003836 14.2%

Female 13-19/NP 0.004755 17.6%

Male 20+ 0.005585 20.7%

Female 20+/NP 0.007189 26.6%

Seniors 55+ 0.007341 27.2%

All Infants 0.011711 43.4%

Female 13-50 0.006241 23.1%

Children 1-2 0.022300 82.6%

Children 3-5 0.015965 59.1%

Children 6-12 0.008070 29.9%

Youth 13-19 0.004289 15.9%

Adults 20-49 0.005812 21.5%

Adults 50-99 0.007263 26.9%

Female 13-49 0.006193 22.9%

-------------------------------------------------------------------------------