### SAT Report PMN Number: P-14-0234 SAT Date: 1/14/2014 Print Date: 1/31/2014

Related cases : Health related cases: ) Ecotox related ca

Concern levels : Type of Concern: Health Eco Comments Level of Concern: 1-2 2

Persistence Bioaccum Toxicity Comments 2 11

Exposure Based Review : Health: N o Ecotox: N o
Routes of exposure : Health: Drinking Water Inhalation Ecotox: All releases to water Fate: ; Keywords : Keywords: LUNG; IRR-E,L,MM; AQUATOX-A,C
Summary of Assessment :

Fate : Fate Summary: P-14-0234 FATE: MW = Liquid with MP = 11 C (M) S = Disp. / 10 g/L at 25 °C (ICB / M) VP < 1.0E-6 torr at 25 C (E) BP > 400 C (E) H < 1.00E-8 (E) POTW removal (%) = 90 via sorption and biodeg Time for complete ultimate aerobic biodeg = mo Sorption to soils/sediments = moderatePBT Potential: P2B1 *CEB FATE: Migration to ground water = slow - moderate

Health : Health Summary: Absorption is poor all routes based on physical/chemical p roperties. The PMN substance is a , with activity increasing with increasing number of . There are concerns for lung effects and irritation to the eye, lung, and mucous membranes, based on t activity. There is particular concern for eye irritation from because they can anesthetize the eye and allow significant damage to occur before adverse effects are realized. Test Data: slightly irritating to not irritating to

Ecotox :
Test Organism Test Type Test End Point Predicted Measured Comments

96-h LC50 1.2 1.2 daphnid 48-h LC50 1.2 green algal 96-h EC50 1.2

_ chronic value 0.24 daphnid

_ chronic value 0.24

algal

_ chronic value 0.30
Sewage Sludge 3-h EC50

_ Sewage Sludge

_ Chronic Value _

Ecotox Values Comments: Predictions are based on SARs for ; SAR chemical class =
; effective concentrations based on 100% active ingredients and mean measured concentrations ; hardness <180.0 mg/L as CaCO3; and TOC <2.0 mg/L;

Initial Submission Review of for P-14-0234

PMN Chemical Name:

An acute fish toxicity test was conducted in 2002 with P-14-0234 by for ). The PMN substance is a pigment dispersant used in colorant manufacturing used for textile printing, imported as a 2% dispersionin water EPA determined that P-14-0234 is in the SAR chemical class . The PMN is a liquid with a viscosity of 500 mPa*s at 30oC, melting point of 11°C, an estimated boiling point > 400°C, an estimated vapor p ressure < 1 x 10-6 Torr and a water solubility of 10 g/L. The acute fish test complied with ) for: 1) temperature and water hardness values and, 2) species and number of organisms per replicate.

: In a 96-hour toxicity test, ) were exposed to a dispersion p roduct of P-14-0234 ( p urity not provided) under semi-static conditions with daily renewal. The test substance was reported to be a light brown, slightly turbid, viscous liquid. This study was reported to follow ) ”. Following a range-finding test, single replicates of seven were exposed to a dilution water control (dechlorinated tap water) or the test substance at nominal concentrations of 18, 32, 56, 100 or 180 mg/L. The test solutions were prepared through direct addition of test substance to water. Amounts of test material were each separately dissolved into a final volume of 200 mL of dechlorinated tap water, with the aid of ultrasonication for approximately 5 minutes. The test substance was then dispersed into a final volume of 20 liters of dechlorinated tap water, to give the desired nominal concentrations. The test material preparations were observed to be clear, colorless solutions throughout the duration of the test. During the test, the water temperature was reported to be 14oC and dilution water hardness was 100 mg CaCO3 /L. A loading of 0.23 g
These responses were increased pigmentation, loss of equilibrium, increased pigmentation with loss of equilibrium, loss of equilibrium with swollen abdomens and the presence of . The % mortality at 0 (control), 18, 32, 56, 100 and 180 mg/L was 0, 0, 0, 43, 100 and 100%, respectively. Based on nominal concentrations, the 96-hour LC50 of the dispersion p roduct is 59 mg/L. substance so that the revised LC50 is 1.2 mg/L. This

. 96-hour LC50 = 1.2 mg/L

Conclusions: The is valid. Details recommended under such as test substance p urity, analysis of test substance concentration and duration of to light/dark cycles and O2 concentration were not reported. However, the results concur with and support the SAR predictions for the . Therefore, the chronic and concentrations of concern (CoCs) for P-14-0234, based on SAR predictions for , remain 24 p pb an d 240 p pb, respectively.

Ecotox Study Reviewer: Tracy Wright January 28, 2014

Factors Values Comments Assessment Factor 10 Concentration of Concern 24( p pb) SARs SAR Class Ecotox Category

Ecotox Factors Comments:

SAT Chair: Doritza Pagan-Rodriguez