Amicarbazone Dietary Exposure and Risk Assessment

PC Code: 114004 DP Number: D394925

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF CHEMICAL SAFETY 

AND POLLUTION PREVENTION

MEMORANDUM

Date: 10/5/2011

SUBJECT: Amicarbazone Acute and Chronic Aggregate Dietary (Food and Drinking 

Water) Exposure and Risk Assessments for the Section 3 Registration Action on 

Turfgrass

PC Code: 114004 DP Barcode: D394925

Decision No.: 441345 Registration No.: 66330-46

Petitions: NA Regulatory Action: Section 3 Registration

Risk Assessment Type: Dietary Case No.: NA

TXR No.: NA CAS No.: 129909-90-6

MRID No.: NA 40 CFR: 180.615

 

FROM: Douglas Dotson, Ph.D., Chemist

Risk Assessment Branch II

Health Effects Division (7509P)

THROUGH: William Cutchin, Chemist

Thurston Morton, Chemist

Dietary Exposure Science Advisory Council (DESAC)

TO: Michael Walsh/Kathryn Montague, RM Team 23

Herbicide Branch

Registration Division (7505P)

Executive Summary

Acute and chronic aggregate dietary (food and drinking water) exposure and risk assessments 

were conducted using the Dietary Exposure Evaluation Model DEEM-FCIDTM, Version 2.03 

which uses food consumption data from the U.S. Department of Agriculture’s (USDA’s) 

Continuing Surveys of Food Intakes by Individuals (CSFII) from 1994-1996 and 1998. The 

analyses were conducted as part of a human health risk assessment for the requested use of the 

herbicide amicarbazone on turfgrass and conifers.
Amicarbazone Dietary Exposure and Risk Assessment

PC Code: 114004 DP Number: D394925

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The acute and chronic analyses are both based on conservative estimates of residues in food and 

drinking water. For amicarbazone, drinking water is the greatest contributor to dietary exposure 

and risk. The estimated drinking water concentrations (EDWCs) represent upper-bound 

estimates that might be found in surface water and groundwater as a result of the application of 

amicarbazone on turf and conifers one time at the maximum yearly rate (worst case scenario). In 

addition, tolerance-level residues and 100% crop treated assumptions were made for all food 

commodities. DEEM default processing factors were used for processed commodities for which 

they were available. Because such conservative assumptions were made in the assessments, the 

resulting exposure and risk estimates are considered to be conservative as well. HED is 

confident that the acute and chronic dietary exposure assessments do not underestimate risk to 

the general U.S. population or any population subgroup.

The acute risk estimates are below HED’s level of concern for all population subgroups, 

including those comprised of infants and children. Generally, HED is concerned when risk 

estimates exceed 100% of the population-adjusted dose (PAD). The acute risk estimate for the 

general U.S. population is 8.8% of the acute PAD (aPAD). The population subgroup with the 

highest acute dietary risk estimate is All Infants, which uses 29% of the aPAD. As percent crop 

treated estimates and monitoring data were not incorporated into the acute assessment, the risk 

estimates are being reported at the 95th percentile of exposure.

Chronic risk estimates are below HED’s level of concern for all population subgroups. The risk 

estimate for the general U.S. population is 17% of the chronic PAD (cPAD). The most highly

exposed population subgroup is All Infants (<1 year old), which uses 48% of the cPAD.

Amicarbazone has been classified as “not likely to be a human carcinogen.” As a result, a 

dietary exposure assessment for cancer risk is not necessary.

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population-adjusted dose (PAD). The PAD is equivalent to the 

point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety 

factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. References which discuss the acute and chronic risk assessments in 

more detail are available on the EPA/pesticides web site: “Available Information on Assessing 

Exposure from Pesticides, A User’s Guide,” 21 Jun 2000, web link: 

http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 (20 Aug

1999).

The last dietary exposure assessment performed for amicarbazone was done in 2005, when 

tolerances were first established for the chemical (D313754, D. Dotson, 4/19/2005).
Amicarbazone Dietary Exposure and Risk Assessment

PC Code: 114004 DP Number: D394925

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II. Residue Information

This registration action is being performed for the proposed use on turfgrass. No tolerances are 

being proposed at the present time. Established tolerances are for the combined residues of 

amicarbazone and its metabolites DA amicarbazone and isopropyl-2-OH-DA amicarbazone. For 

risk assessment purposes, additional metabolites are included with the three residues to be used 

for tolerance enforcement. For assessing human dietary exposure to residues in wheat grain (or 

any other rotated cereal grains), the two glucose conjugates of DA OH MKH 3586 are included. 

These conjugates constituted about 30% of the grain TRR at the 138- and 364-day plant back 

intervals. In ruminants, the metabolite tBuOH MKH 3586 is included because of the fact that it 

was the highest level residue in milk (28% TRR) as well as a major metabolite (> 10% TRR) in 

muscle and kidney. For poultry commodities, the metabolites iPr-Acid DA MKH 3586, iPr-1-

OH DA MKH 3586, and iPr-Ene DA MKH 3586 are included in the risk assessment because of 

their presence as major residues in liver, fat, or eggs. These additional metabolites all contain 

the triazolinone ring and, therefore, are considered toxicologically equivalent to the parent. In 

order to account for these metabolites in the dietary exposure analyses, the tolerances were 

multiplied by factors that account for their contribution to the exposure. These factors are given 

in Table 1 along with the recommended tolerances.

Table 1. Residue Values for Use in Dietary Exposure Assessment

Commodity Tolerance 

(ppm)

Metabolite 

Factor

Residue Value Used in Dietary 

Exposure Assessments

Field Corn Grain 0.05 - 0.05

Undelinted Cotton Seed 0.07 - 0.07

Soybean Seed 0.8 - 0.8

Wheat Grain 0.1 1.7 0.17

Wheat Milled Byproducts 0.15 1.7 0.255

Milk 0.01 1.6 0.016

Meat of cattle, goats, hogs, horses, and sheep 0.01 1.2 0.012

Fat of cattle, goats, hogs, horses, and sheep 0.01 - 0.01

Liver of cattle, goats, horses, sheep 1.0 - 1.0

Meat Byproducts (except liver) of cattle, goats, 

horses, and sheep

0.1 1.2 0.12

Hog liver 0.1 - 0.1

Meat Byproducts (except liver) of hogs 0.01 1.2 0.012

Poultry liver 0.01 1.8 0.018
Amicarbazone Dietary Exposure and Risk Assessment

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III. Percent Crop Treated Information

The acute and chronic assessments were both based on the assumption that 100% of all 

commodities with amicarbazone tolerances will be treated.

IV. Drinking Water Data

The estimated drinking water concentrations (EDWCs) used in the dietary risk assessments were

provided by the Environmental Fate and Effects Division (EFED; D384659, A. Shelby, 

9/7/2011). The EDWCs are incorporated directly into this dietary assessment into the food 

categories “water, direct, all sources” and “water, indirect, all sources.” The residues of concern 

in drinking water for risk assessment are parent amicarbazone and its des-amino and N-methyl 

des-amino degradates. The surface water and groundwater estimates were calculated using the 

PRZM/EXAMS and SCI-GROW Models, respectively. The EDWCs given in Table 2 are the

total toxic residues of amicarbazone, which include the des-amino and N-methyl des-amino 

degradates as well as unextracted residues. The EDWCs represent upper-bound estimates that 

might be found in surface water and groundwater as a result of the application of amicarbazone 

on turf and conifers one time at the maximum yearly rate (worst case scenario). 

The groundwater estimate of 136 ppb was used for both the acute and chronic assessments 

because it was higher than all of the surface water values. For more information about EFED’s 

drinking water models, see http://www.epa.gov/oppefed1/models/water/).

Table 2. Amicarbazone EDWCs Determined Using the PRZM/EXAMS and SCI-GROW Models

 

Chemical Surface water EDWCs (ppb) Groundwater

Acute/Chronic

EDWC (ppb)

Peak 96 hour 

average

Peak annual 

average 30 Year Average

Total Toxic Residues 

of amicarbazone 33.3 25.8 11.1 136

EDWCs would be reduced if degradates were not assumed to be of equal toxicity as parent 

amicarbazone or if unextracted residues were determined to be bound residues. Exclusion of 

degradates and bound residue results in reduction of EDWCs by as much as 70%. Exclusion of 

bound residues results in reduction of EDWCs by as much as 20%. 

V. DEEM-FCIDTM Program and Consumption Information

Amicarbazone acute and chronic dietary exposure assessments were conducted using the Dietary

Exposure Evaluation Model software with the Food Commodity Intake Database DEEM-
Amicarbazone Dietary Exposure and Risk Assessment

PC Code: 114004 DP Number: D394925

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FCIDTM,Version 2.03 which incorporates consumption data from USDA’s CSFII, 1994-1996 

and 1998. The 1994-96, 98 data are based on the reported consumption of more than 20,000 

individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) are 

linked to EPA-defined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; baked; 

or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files 

developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data 

are averaged for the entire U.S. population and within population subgroups, but for acute 

exposure assessment are retained as individual consumption events. Based on analysis of the 

1994-96, 98 CSFII consumption data, which took into account dietary patterns and survey

respondents, HED concluded that it is most appropriate to report risk for the following 

population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, 

children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total 

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent 

of the cPAD. This procedure is performed for each population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or “matched” in multiple random pairings with residue values 

and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating 

relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 

commodities as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for all tiers of analysis. However, for tiers 1 and 2, any significant 

differences in user vs. per capita exposure and risk are specifically identified and noted in the 

risk assessment.

VI. Toxicological Information

Adequate data have been submitted to characterize the toxicity of amicarbazone for the purposes 

of dietary risk assessment. Acute and chronic dietary endpoints were selected for the general 

U.S. population and all population subgroups including those comprised of infants and children. 

The toxicological doses and endpoints selected for human health risk assessment are summarized 

in Table 3, below. The FQPA Safety Factor was reduced to 1x. Amicarbazone is classified as 

“not likely to be a human carcinogen.” 
Amicarbazone Dietary Exposure and Risk Assessment

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Table 3. Summary of Toxicological Doses and Endpoints for Amicarbazone for Use in Dietary 

Human Health Risk Assessments

Exposure/ 

Scenario

Point of 

Departure

Uncertainty/FQP

A Safety Factors

RfD, PAD, 

Level of 

Concern for 

Risk 

Assessment

Study and Toxicological Effects

Acute Dietary 

(General 

Population, 

including 

Infants and 

Children and 

Females 13-49 

years of age)

NOAEL= 

10

mg/kg/day

UFA= 10x

UFH=10x

FQPA SF= 1x

Acute RfD = 

0.10

mg/kg/day

aPAD =0.10

mg/kg/day

Acute Oral Neurotoxicity Screening 

Battery

LOAEL = 20 mg/kg/day based on eyelid 

ptosis, decreased approach response and 

red nasal staining in females

Chronic 

Dietary 

(General 

Population, 

including 

Infants and 

Children and 

Females 13-49 

years of age)

NOAEL= 

2.3

mg/kg/day

UFA= 10x

UFH=10x

FQPA SF= 1x

Chronic RfD 

= 0.023

mg/kg/day

cPAD = 0.023

mg/kg/day

Chronic Oral Rat and Chronic Oral Dog 

(co-critical)

Rat LOAEL = 25.3 mg/kg/day based on 

decreased body weight and weight gain

Dog LOAEL = 8.7 mg/kg/day based on 

liver effects, including increased 

absolute/relative liver weights, 

triglycerides and cholesterol 

Cancer (oral, 

dermal, 

inhalation)

Classification: There was no treatment-related increase in tumor incidence when compared to 

control. Dosing was considered adequate. This chemical is not likely to be a carcinogen.

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and 

used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human 

exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = 

uncertainty factor. UFA = extrapolation from animal to human (interspecies). UFH = potential variation in 

sensitivity among members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = 

population adjusted dose (a = acute, c = chronic). RfD = reference dose.

VII. Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 

100% of the PAD. The DEEM-FCIDTM analyses estimate the dietary exposure of the U.S. 

population and various population subgroups. The results reported in Table 5 are for the general 

U.S. Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, 

females 13-49, adults 20-49, and adults 50+ years. Risk estimates are below HED’s level of 

concern for all population subgroups in both the acute and chronic analyses. The acute risk 

estimate for the general U.S. population is 8.8% of the aPAD. The population subgroup with the 

highest acute risk estimate is All Infants, which uses 29% of the aPAD. The chronic risk 

estimate for the general U.S. population is 17% of the cPAD. The most highly exposed 

population subgroup is All Infants, which uses 48% of the cPAD. As amicarbazone is not likely

to be a human carcinogen, a dietary exposure assessment for the purpose of assessing cancer risk 

is not necessary.
Amicarbazone Dietary Exposure and Risk Assessment

PC Code: 114004 DP Number: D394925

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Full listings of exposure and risk estimates are included in Attachments 2 (acute analysis) and 3

(chronic analysis).

Table 4. Summary of Acute and Chronic Dietary (Food and Drinking Water) Exposure and Risk 

Estimates for Amicarbazone

Population 

Subgroup

Acute Assessment (95th Percentile) Chronic Assessment

aPAD, 

mg/day

Exposure Estimate, 

mg/day

% aPad cPAD, 

mg/day

Exposure Estimate, 

mg/day

% cPad

U.S. Population 0.10 0.008807 8.8 0.023 0.003889 17

All infants 0.10 0.029429 29 0.023 0.010987 48

Children 1-2 yrs 0.10 0.014750 15 0.023 0.006921 30

Children 3-5 yrs 0.10 0.013469 13 0.023 0.006474 28

Children 6-12 yrs 0.10 0.009356 9.4 0.023 0.004469 19

Youth 13-19 yrs 0.10 0.006999 7.0 0.023 0.003120 14

Adults 20-49 yrs 0.10 0.007621 7.6 0.023 0.003472 15

Adults 50+ yrs 0.10 0.006711 6.7 0.023 0.003441 15

Females 13-49 yrs 0.10 0.007603 7.6 0.023 0.003431 15

As drinking water is a major contributor to dietary risk for the general U.S. population and all 

population subgroups, commodity contribution analyses were performed to determine the 

contribution of drinking water to the total dietary exposure estimates. In the acute analyses, 

drinking water contributed between 76% and 90% of the total exposure. In the chronic analyses, 

drinking water contributed between 62% and 86% of the total exposure. The results of the 

analyses are given in Table 5, below.

Table 5. Contribution of Residues in Drinking Water to Total Dietary 

Exposure

Population Subgroup Acute Assessment

% of Total Dietary 

Exposure

Chronic Assessment

% of Total Dietary 

Exposure

U.S. Population 80 74

All infants 90 86

Children 1-2 yrs 74 62

Children 3-5 yrs 76 62

Children 6-12 yrs 76 62

Youth 13-19 yrs 85 66

Adults 20-49 yrs 88 77

Adults 50+ yrs 90 82

Females 13-49 yrs 89 78
Amicarbazone Dietary Exposure and Risk Assessment

PC Code: 114004 DP Number: D394925

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VIII. Characterization of Inputs/Outputs

HED considers both the acute and chronic assessments to be very conservative. For 

amicarbazone, drinking water is the greatest contributor to dietary exposure and risk. The

EDWCs represent upper-bound estimates that might be found in surface water and groundwater 

as a result of the application of amicarbazone on turf and conifers one time at the maximum 

yearly rate (worst case scenario). The EDWCs would be reduced if degradates were not assumed 

to be of equal toxicity as parent amicarbazone or if unextracted residues were determined to be 

bound residues. Exclusion of degradates and bound residue results in reduction of EDWCs by as 

much as 70%. Exclusion of bound residues results in reduction of EDWCs by as much as 20%. 

 

Although food commodities do not contribute significantly to the total dietary exposure, minor 

reductions in the exposure and risk estimates could be made through the use of refinements. The 

assessments are based on tolerance-level residues for all commodities. Conservative processing 

factors were used for all processed commodities for which they were available. In addition, it is 

assumed that 100% of all crops with registered uses of amicarbazone are treated. Further 

refinements to these analyses could be made through the use of anticipated residues (e.g., 

distributions of field trial data for the acute assessment and average field trial values for the 

chronic assessment) and percent crop treated estimates. However, as all risk estimates are not of 

concern, it is not necessary to make any refinements to the dietary exposure assessments. 

IX. Conclusions

The exposure estimates that were generated are very conservative estimates of the actual dietary

exposures that might occur. The aggregate (food + water) dietary risk estimates are below 

HED’s level of concern for all population subgroups for both the acute and chronic exposure 

scenarios. HED is confident that the acute and chronic dietary exposure assessments do not 

underestimate risk to the general U.S. population or any population subgroup.

X. List of Attachments

Attachment 1. Acute and Chronic Dietary Residue Input File for Amicarbazone

Attachment 2. Results of Acute Dietary Exposure Assessment

Attachment 3. Results of Chronic Dietary Exposure Assessment
Amicarbazone Dietary Exposure and Risk Assessment

PC Code: 114004 DP Number: D394925

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Attachment 1: Acute and Chronic Dietary Residue Input File for Amicarbazone

DEEM FCID Version 2.03

Acute NOAEL for general population and all population subgroups: 10 mg/kg bw/day

Acute PAD for general population and all population subgroups: 0.10 mg/kg bw/day

Chronic NOAEL for general population and all population subgroups: 2.3 mg/kg bw/day

Chronic PAD for general population and all population subgroups: 0.023 mg/kg bw/day

Filename: C:\Documents and Settings\ddotson\My Documents\Deemfcid\

Amicarbazone\Amicarbazone2011.R98

Date created/last modified: 10-01-2011/14:33:04/8

--------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ -------

06003470 6 Soybean, seed 0.800000 1.000 1.000 

06003480 6 Soybean, flour 0.800000 1.000 1.000 

06003481 6 Soybean, flour-babyfood 0.800000 1.000 1.000 

06003490 6 Soybean, soy milk 0.800000 1.000 1.000 

06003491 6 Soybean, soy milk-babyfood or in 0.800000 1.000 1.000 

06003500 6 Soybean, oil 0.800000 1.000 1.000 

06003501 6 Soybean, oil-babyfood 0.800000 1.000 1.000 

15001200 15 Corn, field, flour 0.050000 1.000 1.000 

15001201 15 Corn, field, flour-babyfood 0.050000 1.000 1.000 

15001210 15 Corn, field, meal 0.050000 1.000 1.000 

15001211 15 Corn, field, meal-babyfood 0.050000 1.000 1.000 

15001220 15 Corn, field, bran 0.050000 1.000 1.000 

15001230 15 Corn, field, starch 0.050000 1.000 1.000 

15001231 15 Corn, field, starch-babyfood 0.050000 1.000 1.000 

15001240 15 Corn, field, syrup 0.050000 1.500 1.000 

15001241 15 Corn, field, syrup-babyfood 0.050000 1.500 1.000 

15001250 15 Corn, field, oil 0.050000 1.000 1.000 

15001251 15 Corn, field, oil-babyfood 0.050000 1.000 1.000 

15004010 15 Wheat, grain 0.170000 1.000 1.000 

15004011 15 Wheat, grain-babyfood 0.170000 1.000 1.000 

15004020 15 Wheat, flour 0.255000 1.000 1.000 

15004021 15 Wheat, flour-babyfood 0.255000 1.000 1.000 

15004030 15 Wheat, germ 0.255000 1.000 1.000 

15004040 15 Wheat, bran 0.255000 1.000 1.000 

21000440 M Beef, meat 0.012000 1.000 1.000 

21000441 M Beef, meat-babyfood 0.012000 1.000 1.000 

21000450 M Beef, meat, dried 0.012000 1.920 1.000 

21000460 M Beef, meat byproducts 0.120000 1.000 1.000 

21000461 M Beef, meat byproducts-babyfood 0.120000 1.000 1.000 

21000470 M Beef, fat 0.010000 1.000 1.000 

21000471 M Beef,fat-babyfood 0.010000 1.000 1.000 

21000480 M Beef, kidney 0.120000 1.000 1.000 

21000490 M Beef, liver 1.000000 1.000 1.000 

21000491 M Beef, liver-babyfood 1.000000 1.000 1.000 

23001690 M Goat, meat 0.012000 1.000 1.000 

23001700 M Goat, meat byproducts 0.120000 1.000 1.000 

23001710 M Goat, fat 0.010000 1.000 1.000 
Amicarbazone Dietary Exposure and Risk Assessment

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23001720 M Goat, kidney 0.120000 1.000 1.000 

23001730 M Goat, liver 1.000000 1.000 1.000 

24001890 M Horse, meat 0.012000 1.000 1.000 

25002900 M Pork, meat 0.012000 1.000 1.000 

25002901 M Pork, meat-babyfood 0.012000 1.000 1.000 

25002910 M Pork, skin 0.012000 1.000 1.000 

25002920 M Pork, meat byproducts 0.012000 1.000 1.000 

25002921 M Pork, meat byproducts-babyfood 0.012000 1.000 1.000 

25002930 M Pork, fat 0.010000 1.000 1.000 

25002931 M Pork, fat-babyfood 0.010000 1.000 1.000 

25002940 M Pork, kidney 0.012000 1.000 1.000 

25002950 M Pork, liver 0.100000 1.000 1.000 

26003390 M Sheep, meat 0.012000 1.000 1.000 

26003391 M Sheep, meat-babyfood 0.012000 1.000 1.000 

26003400 M Sheep, meat byproducts 0.120000 1.000 1.000 

26003410 M Sheep, fat 0.010000 1.000 1.000 

26003411 M Sheep, fat-babyfood 0.010000 1.000 1.000 

26003420 M Sheep, kidney 0.120000 1.000 1.000 

26003430 M Sheep, liver 1.000000 1.000 1.000 

27002220 D Milk, fat 0.016000 1.000 1.000 

27002221 D Milk, fat - baby food/infant for 0.016000 1.000 1.000 

27012230 D Milk, nonfat solids 0.016000 1.000 1.000 

27012231 D Milk, nonfat solids-baby food/in 0.016000 1.000 1.000 

27022240 D Milk, water 0.016000 1.000 1.000 

27022241 D Milk, water-babyfood/infant form 0.016000 1.000 1.000 

27032251 D Milk, sugar (lactose)-baby food/ 0.016000 1.000 1.000 

40000940 P Chicken, liver 0.018000 1.000 1.000 

50003830 P Turkey, liver 0.018000 1.000 1.000 

60003020 P Poultry, other, liver 0.018000 1.000 1.000 

86010000 O Water, direct, all sources 0.136000 1.000 1.000 

86020000 O Water, indirect, all sources 0.136000 1.000 1.000 

95001280 O Cottonseed, oil 0.070000 1.000 1.000 

95001281 O Cottonseed, oil-babyfood 0.070000 1.000 1.000 
Amicarbazone Dietary Exposure and Risk Assessment

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Attachment 2: Results of Acute Dietary Exposure Assessment

Residue file: Amicarbazone2011.R98 

Analysis Date: 10-01-2011/14:39:50 

Residue file dated: 10-01-2011/14:33:04/8

Daily totals for food and foodform consumption used.

===============================================================================

Summary calculations (per capita):

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE 

---------- ------- -------- ---------- ------- -------- ---------- ------- --------

U.S. Population:

 0.008807 8.81 1135 0.015320 15.32 652 0.029257 29.26 341 

All infants:

 0.029429 29.43 339 0.042121 42.12 237 0.071274 71.27 140 

Children 1-2 yrs:

 0.014750 14.75 677 0.023625 23.62 423 0.041600 41.60 240 

Children 3-5 yrs:

 0.013469 13.47 742 0.019734 19.73 506 0.035375 35.37 282 

Children 6-12 yrs:

 0.009356 9.36 1068 0.014263 14.26 701 0.019715 19.72 507 

Youth 13-19 yrs:

 0.006999 7.00 1428 0.010993 10.99 909 0.018113 18.11 552 

Adults 20-49 yrs:

 0.007621 7.62 1312 0.012089 12.09 827 0.020763 20.76 481 

Adults 50+ yrs:

 0.006711 6.71 1490 0.009375 9.38 1066 0.015091 15.09 662 

Females 13-49 yrs:

 0.007603 7.60 1315 0.011946 11.95 837 0.019959 19.96 501 
Amicarbazone Dietary Exposure and Risk Assessment

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Attachment 3: Results of Chronic Dietary Exposure Assessment

Residue file name: C:\Documents and Settings\ddotson\My Documents\Deemfcid\

Amicarbazone\Amicarbazone2011.R98

Residue file dated: 10-01-2011/14:33:04/8

Analysis Date: 10-01-2011/14:42:17

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ---------------

U.S. Population (total) 0.003889 16.9%

U.S. Population (spring season) 0.003870 16.8%

U.S. Population (summer season) 0.004080 17.7%

U.S. Population (autumn season) 0.003802 16.5%

U.S. Population (winter season) 0.003802 16.5%

Northeast region 0.003623 15.8%

Midwest region 0.003978 17.3%

Southern region 0.003704 16.1%

Western region 0.004327 18.8%

Hispanics 0.004292 18.7%

Non-hispanic whites 0.003811 16.6%

Non-hispanic blacks 0.003751 16.3%

Non-hisp/non-white/non-black 0.004624 20.1%

All infants (< 1 year) 0.010987 47.8%

Nursing infants 0.004012 17.4%

Non-nursing infants 0.013634 59.3%

Children 1-6 yrs 0.006499 28.3%

Children 7-12 yrs 0.004243 18.4%

Females 13-19 (not preg or nursing) 0.002931 12.7%

Females 20+ (not preg or nursing) 0.003535 15.4%

Females 13-50 yrs 0.003588 15.6%

Females 13+ (preg/not nursing) 0.003671 16.0%

Females 13+ (nursing) 0.004902 21.3%

Males 13-19 yrs 0.003284 14.3%

Males 20+ yrs 0.003361 14.6%

Seniors 55+ 0.003431 14.9%

Children 1-2 yrs 0.006921 30.1%

Children 3-5 yrs 0.006474 28.1%

Children 6-12 yrs 0.004469 19.4%

Youth 13-19 yrs 0.003120 13.6%

Adults 20-49 yrs 0.003472 15.1%

Adults 50+ yrs 0.003441 15.0%

Females 13-49 yrs 0.003431 14.9%

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