**Exhibit 10.45****SURRENDER OF LEASE**WHEREAS **THE WESTAIM CORPORATION**(“Lessor”) and **NUCRYST PHARMACEUTICALS CORP.**(“Lessee”)entered into a Memorandum of Lease Agreement dated July 1, 2005 (the” Original Lease Agreement”)which was amended by Letter Agreement dated November 14, 2005 (the “First Amending LeaseAgreement”), by a second amending lease agreement dated April 27, 2006 (the “Second Amending LeaseAgreement”), by a third amending lease agreement dated August 8, 2006 (the “Third Amending LeaseAgreement”), and by a fourth amending lease agreement dated April 30, 2007 (the “Fourth AmendingLease Agreement”), collectively the “Lease Agreement”;AND WHEREAS the Lessor assigned all of its interest in the Lease Agreement to SherrittInternational Corporation, the purchaser of the lands of which the Leased Premises form part, byvirtue of an Assignment and Assumption of Leases dated May 7, 2007;AND WHEREAS pursuant to the Fourth Amending Lease Agreement the parties hereto wish to confirm theterms under which the Lessee will surrender the3rd Floor Surrendered Premises and theSurrendered Parking Stalls;NOW THEREFORE in consideration of the mutual covenants and agreements herein contained and forother good and valuable consideration now exchanged by and between the parties (the receipt andsufficiency of which consideration is hereby irrevocably acknowledged by the parties), the partieshereto agree as follows:1.     The Lessee hereby surrenders and yields up to the Lessor from September 30, 2007 (the“Effective Date”) any and all interest of the Lessee to the 3rd Floor SurrenderedPremises and the Lease Agreement as it pertains to the 3rd Floor Surrendered Premisesand the Surrendered Parking Stalls, and the surrender of the 3rd Floor SurrenderedPremises and the Surrendered Parking Stalls is hereby accepted by the Lessor.2.     The Lessor hereby accepts the condition of the 3rd Floor SurrenderedPremises and the Surrendered Parking Stalls In the manner in which they were vacated by the Lessee.3.     From and after the Effective Date, the Lessee shall be and is hereby released from allfuture obligations owing to the Lessor under the Lease Agreement pertaining to the 3rdFloor Surrendered Premises and Surrendered Parking Stalls, including but not limited toobligations to pay Basic Rent and Additional Rent. Moreover, the Lessee’s obligation to pay itsproportionate share of operating costs of the Complex Common Facilities shall abate according tosquare footage of the 3rd Floor Surrendered Premises. The Lessee acknowledges that itwill remain liable to the Lessor for payment and performance of all obligations under the LeaseAgreement pertaining to the 3rd Floor Surrendered Premises and Surrendered ParkingStalls accruing up to the Effective Date that have not been satisfied or discharged.4.     From and after the Effective Date, the Lessor shall be and is hereby released from anyand all future obligations under the Lease Agreement pertaining to the 3rd FloorSurrendered Premises and the Surrendered Parking Stalls.5.     Except as herein amended, all other provisions, terms and conditions of the LeaseAgreement shall remain the same and in full force and effect,6.     All capitalized terms used herein but not defined shall have the meanings definedtherefore in the Lease Agreement,7.     This Agreement may be executed in one or more counterpart, each of which shall bedeemed to be the original, but all of which together shall constitute one and the same instrument.Counterparts may be executed either in original or facsimile form.IN WITNESS WHEREOF the parties have executed this Agreement by the hands of their duly authorizedofficers in that regard, whose signatures alone are sufficient to bind the parties to the termshereof, effective the30th Day of September, 2007.           **SHERRITT INTERNATIONAL CORPORATION**   **NUCRYST PHARMACEUTICALS CORP.**             Per: /s/ P. Cordingley   Per: /s/ Eliot M. Lurier               Name: P. Cordingley     Eliot M. Lurier    Title: Manager, Procurement andFertilizer Marketing     Vice President, Finance & Administration,Chief Financial Officer                   Per: /s/ Carol L. Amelio                     Carol L. Amelio          Vice President, General Counsel & Corporate Secretary