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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
 Washington, D.C. 20549
 FORM 10-Q/A
 Amendment No. 1
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    Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
 For the quarterly period ended June 30, 2010
 OR
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    Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
 Commission File Number 000-49834
 GEN-PROBE INCORPORATED
  Delaware
    
    33-0044608(State or other jurisdiction of
    
    (I.R.S. Employerincorporation or organization)
    
    Identification Number)10210 Genetic Center DriveSan Diego, CA
    
    92121(Address of Principal Executive Offices)
    
    (Zip Code)
 (858) 410-8000
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  Large accelerated filer þ
    
    Accelerated filer o
    
    Non-accelerated filer o
    
    Smaller Reporting Company o(Do not check if a smaller reporting company)
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TABLE OF CONTENTS  PART II  OTHER INFORMATIONItem 6. ExhibitsSIGNATURESEX-10.2EX-31.3EX-31.4    Table of Contents  EXPLANATORY NOTE
   
 PART II  OTHER INFORMATION
 
 Item 6. Exhibits
 ExhibitNumber
    
    Description2.1(1)
    
    Agreement and Plan of Merger, dated as of October 6, 2009, by and among Gen-Probe
Incorporated, Prodigy Acquisition Corp., Prodesse, Inc. and Thomas M. Shannon and
R. Jeffrey Harris, as the Securityholders Representative Committee.*3.1(2)
    
    Form of Amended and Restated Certificate of Incorporation of Gen-Probe Incorporated.3.2(3)
    
    Certificate of Amendment of Amended and Restated Certificate of Incorporation of
Gen-Probe Incorporated.3.3(4)
    
    Amended and Restated Bylaws of Gen-Probe Incorporated.3.4(5)
    
    Certificate of Elimination of Series A Junior Participating Preferred Stock of
Gen-Probe Incorporated.4.1(2)
    
    Specimen common stock certificate.10.1(6)
    
    Collaboration Agreement, dated as of June 15, 2010, by and between Gen-Probe
Incorporated and Pacific Biosciences of California, Inc.**10.2
    
    Series F Preferred Stock Purchase Agreement, dated as of June 16, 2010, by and
among Gen-Probe Incorporated, Pacific Biosciences of California, Inc. and the other
purchasers party thereto.31.1(6)
    
    Certification dated August 4, 2010, of Principal Executive Officer required
pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 302 of the
Sarbanes-Oxley Act of 2002.31.2(6)
    
    Certification dated August 4, 2010, of Principal Financial Officer required
pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 302 of the
Sarbanes-Oxley Act of 2002.31.3
    
    Certification dated September 10, 2010, of Principal Executive Officer required
pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 302 of the
Sarbanes-Oxley Act of 2002.31.4
    
    Certification dated September 10, 2010, of Principal Financial Officer required
pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 302 of the
Sarbanes-Oxley Act of 2002.32.1(7)
    
    Certification dated August 4, 2010, of Principal Executive Officer required
pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the
Sarbanes-Oxley Act of 2002.32.2(7)
    
    Certification dated August 4, 2010, of Principal Financial Officer required
pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the
Sarbanes-Oxley Act of 2002.101(7)
    
    Interactive Data Files pursuant to Rule 405 of Regulation S-T.
 
 
    
    Filed herewith.*
    
    Gen-Probe has received confidential treatment with respect to certain portions of this
exhibit.




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**
    
    Gen-Probe has requested confidential treatment with respect to certain portions of this
exhibit.(1)
    
    Incorporated by reference to Gen-Probes Annual Report on Form 10-K filed with the SEC on
February 25, 2010.(2)
    
    Incorporated by reference to Gen-Probes Amendment No. 2 to Registration Statement on Form 10
(File No. 000-49834) filed with the SEC on August 14, 2002.(3)
    
    Incorporated by reference to Gen-Probes Quarterly Report on Form 10-Q (File No. 001-31279)
for the quarterly period ended June 30, 2004 filed with the SEC on August 9, 2004.(4)
    
    Incorporated by reference to Gen-Probes Current Report on Form 8-K filed with the SEC on
February 18, 2009.(5)
    
    Incorporated by reference to Gen-Probes Annual Report on Form 10-K for the year ended
December 31, 2006 filed with the SEC on February 23, 2007.(6)
    
    Filed with the SEC as part of the original Form 10-Q on August 4, 2010.(7)
    
    Furnished to the SEC as part of the original Form 10-Q on August 4, 2010.




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SIGNATURES
  GEN-PROBE INCORPORATEDDATE:  September 10, 2010
    By:
    /s/ Carl W. HullCarl W. HullPresident, Chief Executive Officer and Director
(Principal Executive Officer) DATE:  September 10, 2010
    By:
    /s/ Herm RosenmanHerm RosenmanSenior Vice President  Finance and Chief
Financial Officer (Principal Financial Officer and
Principal Accounting Officer)