Federal Register / Vol. 62, No. 62 / Tuesday, April 1, 1997 / Notices 15529

Proposed Project: Program Data Report

Form for the Ryan White

Comprehensive AIDS Resources

Emergency (CARE) Act of 1990, Title III

HIV Early Intervention Services Program

(OMB No. 0915–0158)—Revision and

Extension—Title III of the Ryan White

Comprehensive AIDS Resources

Emergency (CARE) Act of 1990, as

amended by the CARE Act Amendments

of 1996, provides categorical funding to

increase the capacity and capability of

organizations that provide primary

health care to provide HIV-related early

intervention services to medically

underserved persons who have, or are at

high risk for, HIV infection. These

services are provided as part of a

continuum of HIV prevention and

health care services.

This clearance request is for extension

of OMB approval of the Title III Program

Data Report form, which is submitted

annually by Title III grant recipients.

The bulk of the information being

collected describes the epidemiologic

and demographic data on the

populations receiving early intervention

services from grant recipients, and

provides the basis for the annual report

to the Secretary, which is legislatively

mandated. It is also used to monitor the

delivery of services, guide federal

policy, and assist in program

development and evaluation. Only

minor revisions to the form are

proposed, including deletion of some

sections found to lack utility, revision of

some data elements and instructions for

clarity, and addition of data elements to

improve the usefulness of the data.

The estimate of burden for the form is

as follows:

Form name No. of

respondents

Responses

per

respondent

Hours per

response

Total

burden

hours

Program Data Report Form .............................................................................................. 170 1 500 85,000

Send comments to Patricia Royston,

HRSA Reports Clearance Officer, Room

14–36, Parklawn Building, 5600 Fishers

Lane, Rockville, MD 20857. Written

comments should be received within 60

days of this notice.

Dated: March 26, 1997.

J. Henry Montes,

Director, Office of Policy and Information

Coordination.

[FR Doc. 97–8168 Filed 3–31–97; 8:45 am]

BILLING CODE 4160–15–P

The Ryan White Comprehensive AIDS

Resources Emergency Act of 1990, as

Amended by the Ryan White CARE Act

Amendments of 1996

AGENCY: Health Resources and Services

Administration, HHS.

ACTION: Notice of a Pre-Application

Technical Assistance Workshop for

Ryan White Title III HIV Planning

Grants.

SUMMARY: The Health Resources and

Services Administration (HRSA) will

hold a pre-application technical

assistance workshop for competing

applicants for Ryan White Title III HIV

Planning Grants, of Part C of Title XXVI

of the Public Health Service (PHS) Act.

A Ryan White Title III HIV Planning

Grant will assist health care service

entities to qualify for grant support

under the Ryan White Title III Early

Intervention Services Program.

Eligible applicants for the Ryan White

Title III HIV Planning Grants are public

or nonprofit private entities. Grant

recipients of the Ryan White Title III

Early Intervention Services Program are

not eligible to receive Ryan White Title

III HIV Planning Grants.

It should be noted that eligible

applicants for the Ryan White Title III

Early Intervention Services Program are

public or private, nonprofit entities that

are: Current primary care service

providers to populations at risk for HIV

disease; community health centers

under section 330 of the PHS Act;

migrant health centers under section

330(g) of the PHS Act; health care for

the homeless grantees under section

330(h) of the PHS Act; family planning

grantees under section 1001 of the PHS

Act, other than states; comprehensive

hemophilia diagnostic and treatment

centers; or federally qualified health

centers under section 1905(1)(2)(B) of

the Social Security Act.

PURPOSE: The purpose of the preapplication technical assistance

workshop is to provide information

about the Ryan White Title III HIV

Planning Grant program, and to review

application procedures. Information

will also be provided about the Ryan

White Title III Early Intervention

Services Program. Participants will have

the opportunity to review the program

guidance and to receive technical

assistance pertaining to all aspects of

writing a Ryan White Title III HIV

Planning Grant application.

FOR FURTHER INFORMATION AND TO

REGISTER: Anyone interested in

attending this workshop must contact

Ms. Karin Martinsen, Professional and

Scientific Associates, Inc., 8180

Greensboro Drive, Suite 1050, McLean

VA 22102–3823 (phone: 703–442–9824).

Costs of attending the workshop are the

sole responsibility of the attendee.

There is a nominal registration fee of

$50 to cover the cost of materials, lunch

and refreshments.

For general information, contact the

HIV Primary Care Programs Branch,

Division of Programs for Special

Populations, Bureau of Primary Health

Care, 4350 East West Highway,

Bethesda, MD 20814 (telephone: 301–

594–4444).

Date, Time, and Location

Wednesday, April 9, 1997 (the due

date for the Ryan White Title III HIV

Planning Grant is May 1, 1997). 10:00

a.m.–5:00 p.m., St. Louis Airport

Marriot, St. Louis, Missouri, (314) 423–

9700.

The OMB Catalog of Federal Domestic

Assistance number for this program is

93.918.

Dated: March 26, 1997.

Claude Earl Fox,

Acting Administrator.

[FR Doc. 97–8167 Filed 3–31–97; 8:45 am]

BILLING CODE 4160–15–P

National Institutes of Health

National Institute of Child Health and

Human Development: Opportunity for

a Cooperative Research and

Development Agreement (CRADA) for

the Development of a Microbial Screen

for Anti-Virals Targeting PKR or

Inhibitors of PKR

AGENCY: National Institutes of Health,

Public Health Service, DHHS.

ACTION: Notice.

SUMMARY: The National Institutes of

Health is seeking one or more CRADA

partners for further development and

evaluation of a microbial screen in yeast

to identify anti-viral agents that target

regulators of and/or the PKR kinase. The

National Institute of Child Health and

Human Development has established a

system in yeast to identify and
15530 Federal Register / Vol. 62, No. 62 / Tuesday, April 1, 1997 / Notices

characterize viral regulators of the PKR

kinase, that should also be useful for

identifying anti-viral agents that

counteract the viral regulators. To

expedite research and development of

this system, the National Institutes of

Health is seeking CRADAs with

pharmaceutical or biotechnology

companies in accordance with the

regulations governing the transfer of

Government-developed agents. Any

proposal to use or develop this system

will be considered.

ADDRESSES: CRADA proposals and

questions about this opportunity should

be addressed to: Dr. Gordon Guroff,

Deputy Scientific Director, National

Institute of Child Health and Human

Development, Building 49, Room 5A64,

Bethesda, MD 20892 (301/496–4751).

DATES: CRADA proposals should be

received on or before July 30, 1997 for

priority consideration. However,

CRADA proposals submitted thereafter

will be considered until a suitable

CRADA Collaborator is selected.

SUPPLEMENTARY INFORMATION: The

protein kinase PKR is a component of

the interferon-induced anti-viral defense

mechanism in mammalian cells. Upon

activation by binding double-stranded

RNA in infected cells, the kinase downregulates the cellular translational

apparatus, and thus impairs viral

protein expression. To overcome the

inhibitory effects of PKR, viruses have

developed efficient methods to prevent

the activation or function of the kinase.

A potential site of therapeutic

intervention is to block viral inhibition

of PKR.

The NICHD has developed a microbial

system in the yeast Saccharomyces

cerevisiae in which expression of PKR

inhibits growth by down-regulating

cellular protein synthesis. The toxicity

of PKR in this system can be relieved by

co-expression of viral regulatory factors

including the vaccinia virus K3L

protein. This simple microbial system

should be amenable to high through-put

screens to identify anti-viral agents that

inactivate viral regulators of PKR, and

thus restore PKR toxicity in this system.

In addition, agents that act on PKR and

reduce the sensitivity of PKR to viral

regulatory factors could also be

identified. This system should also be

useful to identify regulators of PKR from

other viruses, and then subsequently

used to identify inhibitors of these

newly identified viral regulatory factors.

In an effort to expedite research and

development of new anti-viral agents

targeting PKR, the National Institute of

Child Health and Human Development

seeks a CRADA partner(s) for joint

exploration. Any CRADA proposals for

use of this system will be considered.

The CRADA aims will include the

rapid publication of research results

consistent with protection of proprietary

information and patentable inventions

as well as the timely exploitation of

commercial opportunities. The CRADA

partner will enjoy the benefits of first

negotiation for licensing Government

rights to any inventions arising under

the agreement and will advance funds

payable upon signing the CRADA to

help defray Government expenses for

patenting such inventions and other

CRADA-related costs.

The role of the National Institute of

Child Health and Human Development

will be as follows:

1. Provide the collaborator with the

data on the system covered by the

agreement.

2. Provide the yeast strains and

plasmids covered by the agreement.

3. Continue studies on the system to

optimize growth tests for screens.

4. Work cooperatively with the

Collaborator to perform the necessary

controls to validate results from screens.

5. Jointly identify additional PKR

inhibitors, and establish necessary

strains for anti viral screens.

The role of the Collaborator will be as

follows:

1. Undertake studies to evaluate the

usefulness of this system for high

through-put screens.

2. Cooperate to identify additional

PKR inhibitors that could be tested

using this system.

3. Undertake studies using this system

to identify agents that inactivate viral

inhibitors of PKR.

Selection criteria for choosing the

CRADA Collaborator(s) will include but

are not limited to the following:

1. The ability to collaborate with the

NICHD on further research and

development of this technology. This

ability can be demonstrated through

experience and expertise in this and

related areas of technology.

2. The demonstration of adequate

resources to perform the research and

development of this technology (e.g.,

personnel, expertise, and facilities) and

accomplish objectives according to an

appropriate timetable to be outlined in

the CRADA Collaborator’s proposal.

3. The level of financial support the

CRADA Collaborator will provide for

CRADA related Government activities.

4. The willingness to cooperate with

the NICHD in publication of research

results consistent with the protection of

proprietary information and patentable

inventions which may arise during the

period of the agreement.

5. Agreement to be bound by DHHS

rules and regulations regarding human

subjects, patent rights, ethical treatment

of animals, and randomized clinical

trials.

6. Agreement with provisions for

equitable distribution of patent rights to

any inventions developed under the

CRADA(s). Generally, the rights of

ownership are retained by the

organization which is the employer of

the inventor, with an irrevocable, nonexclusive, royalty free license to the

Government (when a company

employee(s) is the sole inventor) or an

option to negotiate an exclusive license

to the company on terms that are

appropriate (when the Government

employee(s) are either sole or joint

inventors).

Dated: March 18, 1997.

Barbara M. McGarey,

Deputy Director, Office of Technology

Transfer.

[FR Doc. 97–8120 Filed 3–31–97; 8:45 am]

BILLING CODE 4140–01–M

DEPARTMENT OF HOUSING AND

URBAN DEVELOPMENT

[Docket No. FR–4200–N–46]

Notice of Proposed Information

Collection for Public Comment

AGENCY: Office of the Assistant

Secretary for Community Planning and

Development, HUD.

ACTION: Proposed information collection

for public comment.

SUMMARY: The proposed information

collection requirement for the State

Community Development Block Grant

(CDBG) program will be submitted to

the Office of Management and Budget

(OMB) for review, as required by the

Paperwork Reduction Act. The

Department is soliciting public

comments on the subject proposal.

DATES: Comment due date: June 2, 1997.

ADDRESSES: Interested persons are

invited to submit comments regarding

this proposal. Comments should refer to

the proposal by name and/or OMB

Control Number and should be sent to:

Reports Liaison Officer, Shelia E. Jones,

Department of Housing & Urban

Development, 451 7th Street, SW, Room

7230, Washington, DC 20410–7000.

FOR FURTHER INFORMATION CONTACT:

Steve Johnson, Acting Director, State

and Small Cities Division, Department

of Housing and Urban Development,

Room 7286, 451 Seventh Street, SW,

Washington, DC 20410–7000. For

telephone communication, contact

Yvette Aidara, State and Small Cities

Division, at 202–708–1322. This is not