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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
 Washington, D.C. 20549
 FORM 10-Q/A
 Amendment No. 1
  þ
    
    Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
 For the quarterly period ended September 30, 2009
 OR
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    Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
 Commission File Number 000-49834
 GEN-PROBE INCORPORATED
  Delaware
    
    33-0044608(State or other jurisdiction of 
incorporation or organization)
    
    (I.R.S. Employer
Identification Number)10210 Genetic Center Drive 
San Diego, CA
(Address of Principal Executive 
Offices)
    
    92121
(Zip Code)
 (858) 410-8000
 þ o
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  Large accelerated filer þ
    
    Accelerated filer o
    
    Non-accelerated filer o
    
    Smaller Reporting Company o(Do not check if a smaller reporting company)
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EXPLANATORY NOTE
    TABLE OF CONTENTS  PART IIItem 6. ExhibitsSIGNATURESEX-10.103EX-31.3EX-31.4    Table of Contents  
 PART II
 
 Item 6. Exhibits
 ExhibitNumber
    
    Description2.1(1)
    
    Recommended Cash Offer for Tepnel Life Sciences plc.2.2(2)
    
    Implementation Agreement dated as of January 30, 2009 by and between Gen-Probe
Incorporated and Tepnel Life Sciences plc.3.1(3)
    
    Form of Amended and Restated Certificate of Incorporation of Gen-Probe Incorporated.3.2(4)
    
    Certificate of Amendment of Amended and Restated Certificate of Incorporation of
Gen-Probe Incorporated.3.3(5)
    
    Amended and Restated Bylaws of Gen-Probe Incorporated.3.4(6)
    
    Certificate of Elimination of Series A Junior Participating Preferred Stock of
Gen-Probe Incorporated.4.1(3)
    
    Specimen common stock certificate.10.103*
    
    Restated Agreement dated as of July 24, 2009 by and between Gen-Probe Incorporated
and Novartis Vaccines and Diagnostics, Inc.10.104**
    
    Nonexclusive License Agreement Under Vysis Collins Patents effective as of June
22, 1999 by and between Gen-Probe Incorporated and Vysis, Inc.10.105**
    
    Development, License and Supply Agreement entered into as of October 16, 2000 by
and between Gen-Probe Incorporated and KMC Systems, Inc.31.1**
    
    Certification dated November 5, 2009, of Principal Executive Officer required
pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 302 of the
Sarbanes-Oxley Act of 2002.31.2**
    
    Certification dated November 5, 2009, of Principal Financial Officer required
pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 302 of the
Sarbanes-Oxley Act of 2002.31.3
    
    Certification dated April 14, 2010, of Principal Executive Officer required
pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 302 of the
Sarbanes-Oxley Act of 2002.31.4
    
    Certification dated April 14, 2010, of Principal Financial Officer required
pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 302 of the
Sarbanes-Oxley Act of 2002.32.1**
    
    Certification dated November 5, 2009, of Principal Executive Officer required
pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the
Sarbanes-Oxley Act of 2002.32.2**
    
    Certification dated November 5, 2009, of Principal Financial Officer required
pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the
Sarbanes-Oxley Act of 2002.
 
 
    
    Filed herewith.*
    
    Gen-Probe has requested confidential treatment with respect to certain portions of this exhibit.




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**
    
    Filed with the SEC as part of the original Form 10-Q on November 5, 2009.(1)
    
    Incorporated by reference to Gen-Probes Current Report on Form 8-K filed with the SEC on
January 30, 2009.(2)
    
    Incorporated by reference to Gen-Probes Current Report on Form 8-K filed with the SEC on
February 5, 2009.(3)
    
    Incorporated by reference to Gen-Probes Amendment No. 2 to Registration Statement on Form 10
filed with the SEC on August 14, 2002.(4)
    
    Incorporated by reference to Gen-Probes Quarterly Report on Form 10-Q for the quarterly
period ended September 30, 2004 filed with the SEC on August 9, 2004.(5)
    
    Incorporated by reference to Gen-Probes Current Report on Form 8-K filed with the SEC on
February 18, 2009.(6)
    
    Incorporated by reference to Gen-Probes Annual Report on Form 10-K for the year ended
December 31, 2006 filed with the SEC on February 23, 2007.




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##### Table of Contents



SIGNATURES
  GEN-PROBE INCORPORATEDDATE: April 14, 2010
    By:
    /s/ Carl W. HullCarl W. HullPresident, Chief Executive Officer and Director
(Principal Executive Officer)DATE: April 14, 2010
    By:
    /s/ Herm RosenmanHerm RosenmanSenior Vice President  Finance and Chief
Financial Officer (Principal Financial Officer and
Principal Accounting Officer)