SAT Report

PMN Number: P-15-0573

SAT Date: 7/14/2015

Print Date: 11/3/2015

Related cases: Yes

Health related cases: 

Ecotox related cases: 

Concern levels:

Type of Concern: Health Eco Comments

Level of Concern: 2 2

 Persistence Bioaccum Toxicity Comments

1 12

Exposure Based Review:

Health: No

Ecotox: No

Routes of exposure: Health: Dermal Drinking Water Inhalation 

Ecotox: All releases to water

Fate: ;

Keywords:

 Keywords: ONCO SENS-DERMAL/RESPIRATORY MUTA DEVEL IRR 

NEURO ACUTE TOX AQUATOX-A,C

Summary of Assessment:

 Fate:

Fate Summary: P-15-0573

FATE: 

Liquid with MP < 25 °C (E)

log Kow = 1.63 (E) 

S = 6.8 g/L at 25 °C (E)

VP = 4.9E-2 torr at 25 °C (NOMO5)

BP = 236 °C (NOMO5) based on 118 °C @ 13 mm Hg (M)

H = 5.21E-6 (E)

log Koc = 1.27 (E)
log Fish BCF = 0.75 (E)

log Fish BAF = 0.64 (E) 

POTW removal (%) = 90 via biodeg

Time for complete ultimate aerobic biodeg = wk

Sorption to soils/sediments = low

Volatilization half-life from a standard river = 140 hrs

Volatilization half-life from a standard lake = 66 da

Atmospheric Oxidation Half-life = 4.1 hr via OH radical

PBT Potential: P1B1

*CEB FATE: Migration to ground water = moderate

 Health:

 Health Summary: Expect absorption/reaction all routes (pchem/analogs). 

The PMN compound is a potential alkylating agent. Expect oxidation of the aldehyde group to 

the corresponding acid. There is concern for oncogenicity by analogy to furfural and based on 

the potential to be an alkylating agent. This compound may be a crosslinking agent. There is 

also concern for dermal and respiratory sensitization, mutagenicity, and developmental toxicity 

as a potential alkylating agent. There is also concern for neurotoxicity and acute toxicity by 

analogy to furfural. Moderate concern.

 Test Data: Furfural

8e-6793 – 4-hr inhalation study in rats – no deaths at 0.176 or 0.370 mg/L, hypoactivity, ruffled 

fur, enophthalmus, ptosis, reduced respiratory rates

8e-6798 – acute oral LD50 in rats – LD50 is in the range of 90 to 204 mg/kg

8e-13824 – positive for chromosome aberrations

8e-13916 – range-finding developmental toxicity study in rats – deaths or moribund condition in 

all animals at 250 mg/kg and greater; rales, lethargy, prostration, tremors, labored respiration, 

exophthalmia, vocalization, shallow respiration at 150 mg/kg

8e-14026 – oral developmental toxicity in rats – deaths at 100 and 150 mg/kg; maternal effects 

in all dose groups (50 mg/kg lowest dose tested); reduced maternal and fetal weights at 150 

mg/kg

8e-15585 – 28-day dermal study in rats (25, 50, 100 mg/kg) – signs of neurotoxicity at 100 

mg/kg

NTP TR-382 – 2-year gavage studies – some evidence of carcinogenic activity in male rats 

(cholangiocarcinomas, bile duct dysplasia with fibrosis); no evidence of carcinogenic activity in 

female rats; clear evidence of carcinogenic activity in male mice (hepatocellular adenomas and 

hepatocellular carcinomas; some evidence of carcinogenic activity in female mice 

(hepatocellular adenomas)

 Ecotox:

Test 

Organism

Test 

Type

Test End 

Point

Predicted Measured Comments

fish 96-h LC50 13

daphnid 48-h LC50 25

green algal 96-h EC50 35