July 12, 1999

EPA-SAB-CASAC-CON-99-006

Honorable Carol M. Browner

Administrator

U.S. Environmental Protection Agency

401 M Street, SW

Washington, DC 20460

Subject: Notification of a Consultation on the Estimation of Carbon

Monoxide Exposures and Associated Carboxyhemoglobin Levels

in Denver Residents using pNEM/CO (Ver. 2.0) 

Dear Ms. Browner:

The Clean Air Scientific Advisory Committee (CASAC) of the Science Advisory Board

(SAB), met on June 9-10, 1999 to review and/or consult on several issues. During the meeting,

the Committee conducted a Consultation with staff from the Office of Air and Radiation (OAR)

on OAR’s draft Estimation of Carbon Monoxide Exposures and Associated Carboxyhemoglobin

Levels in Denver Residents using pNEM/CO (Ver. 2.0). This document was discussed as part of

the continuing peer review by CASAC of the National Ambient Air Quality Standards (NAAQS)

for Carbon Monoxide. 

The SAB has developed the Consultation as a mechanism to advise the Agency on

technical issues that should be considered in the development of regulations, guidelines, or

technical guidance before the Agency has taken a position. A Consultation is conducted under

the normal requirements of the Federal Advisory Committee Act, which include advance notice

of the public meeting in the Federal Register.

As is our customary practice, there will be no formal report from the SAB as a result of

this consultation, nor do we expect any formal response from the Agency. However, the

Committee looks forward to continuing its peer review of the scientific basis of the Carbon

Monoxide NAAQS.

Sincerely,

Dr. Joe Mauderly, Chair

Clean Air Scientific Advisory Committee

Science Advisory Board
i

U.S. Environmental Protection Agency

Science Advisory Board

Clean Air Scientific Advisory Committee (CASAC)

Chair

Dr. Joe Mauderly, Director of External Affairs, Senior Scientist, Director of National Environmental

Respiratory Center, Lovelace Respiratory Research Institute, Albuquerque, NM

Members

Mr. John Elston, Administrator, Office of Air Quality Management, State of New Jersey, Department of

Environmental Protection and Energy, Trenton, NJ

Dr. Philip K. Hopke, Dean of the Graduate School, and R.A. Plane Professor of Chemistry, Clarkson

University, Potsdam, NY

Dr. Eva J. Pell,, Steimer Professor of Agricultural Sciences, Pennsylvania State University, University

Park, PA

Dr. Arthur C. Upton, M.D., Director, Independent Peer Review, CRESP, Environmental and

Occupational Health Sciences Institute, Piscataway, NJ

Dr. Sverre Vedal, M.D., Professor of Medicine, University of British Columbia, Vancouver, BC, Canada

Dr. Warren White, Senior Research Associate, Washington University, Chemistry Department, St.

Louis, MO

Consultants

Dr. Stephen M. Ayres, M.D., Director, International Health Programs, Virginia Commonwealth

University/Medical College of Virginia, Richmond, VA

Dr. Thomas E. Dahms, Professor and Director, Anesthesiology Research, Department of

Anesthesiology, St. Louis University School of Medicine,St. Louis, MO

Dr. Victor G. Laties, Professor Emeritus, Department of Environmental Medicine, University of

Rochester Medical Center, Rochester, NY

Dr. Brian Leaderer, Professor, Division of Environmental Health Sciences, Yale University School of

Medicine, New Haven, CT

Dr. Lawrence D. Longo, M.D., Professor, School of Medicine, Department of Physiology, Center for

Perinatal Biology, Departments of Physiology and Gynecology and Obstetrics, School of

Medicine, Loma Linda University, Loma Linda, CA (did not attend meeting)

Science Advisory Board Staff

Mr. Robert Flaak, Designated Federal Official (DFO) and Team Leader, Committee Operations Staff,

US Environmental Protection Agency, Science Advisory Board, Washington, DC

Ms. Diana Pozun, Management Assistant, US Environmental Protection Agency, Science Advisory
ii

Board, Washington, DC 

NOTICE

This report has been written as a part of the activities of the Science Advisory Board, a

public advisory group providing extramural scientific information and advice to the

Administrator and other officials of the Environmental Protection Agency. The Board is

structured to provide balanced expert assessment of scientific matters related to problems faced

by the Agency. This report has not been reviewed for approval by the Agency; and hence, the

contents of this report do not necessarily represent the views and policies of the Environmental

Protection Agency or other agencies in the Federal government. Mention of trade names or

commercial products does not constitute a recommendation for use.
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