12182 Federal Register / Vol. 62, No. 50 / Friday, March 14, 1997 / Notices

[PF–717; FRL–5590–2]

Bayer Corporation; Pesticide

Tolerance Petition Filing

AGENCY: Environmental Protection

Agency (EPA).

ACTION: Notice of filing.

SUMMARY: This notice announces the

filing of a pesticide petition proposing

regulations establishing tolerances for

residues of the pyrethroid cyfluthrin in

or on the raw agricultural commodities

(RACs) group citrus, fruits and to

establish a maximum residue limit for

cyfluthrin on citrus oil and dried pulp.

This notice includes a summary of the

petition that was prepared by Bayer

Corporation.

DATES: Comments, identified by the

docket control number [PF–717], must

be received on or before April 14, 1997.

ADDRESSES: By mail, submit written

comments to Public Response and

Program Resources Branch, Field

Operations Division (7506C), Office of

Pesticide Programs, Environmental

Protection Agency, 401 M St. SW.,

Washington, DC 20460. In person, bring

comments to Rm. 1132, CM #2. 1921

Jefferson Davis Highway, Arlington, VA

22202.

Comments and data may also be

submitted electronically be sending

electronic mail (e-mail) to: oppdocket@epamail.epa.gov. Electronic

comments must be submitted as an

ASCII file avoiding the use of special

characters and any form of encryption.

Comments and data will also be

accepted on disks in WordPerfect 5.1

file format or in ASCII file format. All

comments and data in electronic form

must be identified by docket control

number [PF–717]. Electronic comments

on this notice may be filed online at

many Federal Depository Libraries.

Additional information on electronic

submissions can be found below this

document.

Information submitted as a comments

concerning this document may be

claimed confidential by marking any

part or all of that information as

‘‘Confidential Business Information’’

(CBI). CBI should not be submitted

through e-mail. Information marked as

CBI will not be disclosed except in

accordance with procedures set forth in

40 CFR part 2. A copy of the comment

that does not contain CBI must be

submitted for inclusion in the public

record. Information not marked

confidential may be disclosed publicly

by EPA without prior notice. All written

comments will be available for public

inspection in Rm. 1132 at the address

given above, from 8:30 a.m. to 4 p.m.,

Monday through Friday, excluding legal

holidays.

FOR FURTHER INFORMATION CONTACT: By

mail: George T. LaRocca, Product

Manager (PM) 13, Registration Division

(7505C), Office of Pesticide Programs,

Environmental Protection Agency, 401

M St., SW., Washington, DC 20460.

Office location, telephone number, and

e-mail address: Rm. 200, CM #2, 1921

Jefferson Davis Highway, Arlington, VA

22202. (703) 305–6100;

larocca.george@epamail.epa.gov.

SUPPLEMENTARY INFORMATION: EPA has

received pesticide petitions (PP) 4F4313

and 4H5687 from Bayer Corporation,

8400 Hawthorn Road, Kansas City, MO

64120. The petition proposes, pursuant

to section 408(d) of the Federal Food

Drug and Cosmetic Act, 21 U.S.C.

section 346a, to amend 40 CFR 180.436

to establish tolerances for residues of

the insecticide cyfluthrin, [cyano[4-

fluoro-3-phenoxyphenyl]-methyl-3-[2,2-

dicloroethenyl]-2,2-

dimethylcyclopropanecarboxylate] in or

on the raw agricultural commodities

group citrus, fruits at 0.2 part per

million (ppm) and the processed

commodities citrus, oil and citrus, dried

pulp at 0.3 part per million (ppm). The

proposed analytical method is gas

chromatography equipped with electron

capture detector.

As required by section 408(d) of the

FFDCA, as recently amended by the

Food Quality Protection Act, Bayer

Corporation included in the petition a

summary of the petition and

authorization for the summary to be

published in the Federal Register in a

notice of receipt of the petition. The

summary represents the views of Bayer

Corporation; EPA is in the process of

evaluating the petition. As required by

section 408(d)(3) EPA is including the

summary as a part of this notice of

filing. EPA may have made minor edits

to the summary for the purpose of

clarity.

I. Petition Summary

A. Residue Chemistry

1. Use pattern. Baythroid 2 will be

used on citrus only in California and

Arizona, to control citrus thrips. A

dosage of 6.4 fluid ounces of Baythroid

2 (0.1 lb active ingredient per acre) will

be applied by ground equipment only,

in sufficient water for complete

coverage of foliage in dilute or

concentrate sprays, but not less than 25

gallons per acre. A single application

may be made per season.

2. Plant metabolism. The metabolism

of cyfluthrin in plants is adequately

understood. Studies have been

conducted to delineate the metabolism

of radiolabeled cyfluthrin in various

crops all showing similar results. The

residue of concern is cyfluthrin.

3. Analytical methodology. Adequate

analytical methodology (Gas liquid

chromatography with an electron

capture detector) is available for

enforcement purposes.

The established tolerances for

residues of cyfluthrin in/on eggs, milks,

fat, meat and meat by-products of cattle,

goats, hogs, horses, sheep and poultry

are adequate to cover secondary

residues resulting from the proposed

use as delineated in 40 CFR 180.6(a)(2).

4. Magnitude of the residue. On

December 20, 1993, Bayer Corp. filed a

petition (PP 4F4313) for a tolerance for

residues of cyfluthrin on the raw

agricultural commodity, citrus and

proposed food/feed additive regulation

(4H5687) for citrus oil, citrus dried

pulp, and citrus molasses under section

409 of FFDCA. A request was filed May

2, 1996, to withdraw the feed additive

petition for citrus molasses, submitted

in response to EPA’s determination that

citrus molasses is no longer considered

a significant feed item. See EPA’s final

860 Series Residue Chemistry

Guidelines (860.1000) published as

public drafts on August 25, 1995 (60 FR

44343) (formerly Table II of Subdivision

O, Residue Chemistry, of the Pesticide

Assessment Guidelines).

The food/feed additive petition for

citrus oil and citrus dried pulp has been

revised to propose these tolerances at

0.3 ppm under section 408 instead

section 409 in accordance the Food

Quality Protection Act.

The proposed section 408 tolerance

for cyfluthrin on citrus is 0.2 ppm. The

highest average residue found in crop

field trials for cyfluthrin on citrus fruits

was 0.06 ppm. A processing study

showed that in producing citrus oil and

dried pulp residues concentrated 530 (a

concentration factor of 5.3×). Thus with

this information it is likely that

cyfluthrin residues of 0.32 ppm (0.06 ×

5.3) could occur in citrus oil and dried

pulp.

B. Toxicological Profile

The data base for cyfluthrin is

essentially complete. Data lacking but

desirable are an acute neurotoxicity

study in rats and a 90-day neurotoxicity

study in rats. Although these data are

lacking, Bayer Corp. believes there is

sufficient toxicity data to support the

proposed tolerance and these missing

data will not significantly change the

risk assessment. In a letter dated

November 2, 1995, Bayer Corp. has

committed to submit the acute

neurotoxicity study by December 1996
Federal Register / Vol. 62, No. 50 / Friday, March 14, 1997 / Notices 12183

and the 90-day neurotoxicity study by

May 1997.

The toxicology data cited in support

of the tolerance include:

1. Chronic effects. A 12-month

chronic feeding study in dogs with a noobserved effect level (NOEL) of 4 mg/kg/

day. The lowest effect level (LEL) for

this study is established at 16 mg/kg/

day, based on slight ataxia, increased

vomiting, diarrhea and decreased body

weight.

A 24-month chronic feeding/

carcinogenicity study in rats with a

NOEL of 2.5 mg/kg/day and LEL of 6.2

mg/kg/day, based on decreased body

weights in males, decreased food

consumption in males, and

inflammatory foci in the kidneys in

females.

2. Acute toxicity. For the purposes of

assessing acute dietary risk, the Agency

has used an oral developmental toxicity

study in rabbits with a maternal NOEL

of 20 mg/kg/day and a maternal LEL of

60 mg/kg/day, based on decreased body

weight gain and decreased food

consumption during the dosing period.

A fetal NOEL of 20 mg/kg/day and a

fetal LEL of 60 mg/kg/day were also

observed in this study. The LEL was

based on increased resorptions and

increased postimplantation loss.

3. Carcinogenicity. A 24-month

carcinogenicity study in mice was

conducted. There were no carcinogenic

effects observed under the conditions of

the study.

A 24-month chronic feeding/

carcinogenicity study in rats was

conducted. There were no carcinogenic

effects observed under the conditions of

the study.

Mutagenicity tests were conducted,

including several gene mutation assays

(reverse mutation and recombination

assays in bacteria and a Chinese hamster

ovary(CHO)/HGPRT assay); a structural

chromosome aberration assay (CHO/

sister chromatid exchange assay); and

an unscheduled DNA synthesis assay in

rat hepatocytes. All tests were negative

for genotoxicity.

4. Other. A metabolism study in rats

showed that cyfluthrin is rapidly

absorbed and excreted, mostly as

conjugated metabolites in the urine,

within 48 hours. An enterohepatic

circulation was observed.

C. Aggregate Exposure

A chronic dietary exposure/risk

assessment was performed for cyfluthrin

using a Reference Dose (RfD) of 0.025

mg/kg bwt/day, based on a NOEL of 50

ppm (2.5 mg/kg bwt/day) and an

uncertainty factor of 100. The NOEL

was determined in a 2-year rat feeding

study. The endpoint effects of concern

were decreased body weights in males

and inflammation of the kidneys in

females at the LEL of 6.2 mg/kg/day. For

purposes of this dietary exposure/risk

assessment tolerance level residues

were used and percent crop treated

assumption made for some of the

commodities. The current estimated

dietary exposure for the overall U.S.

population resulting from established

tolerances 0.009420 mg/kg/bwt/day or

37.6 percent of the RfD. The current

estimated dietary exposure for the

subgroup population exposed to the

highest risk, non-nursing infants less

than 1 year old, 0.025266 mg/kg bwt/

day or 101 percent of the RfD. Although

the estimate of dietary exposure for the

subgroup, non-nursing infants less than

1 year old, is slightly higher than the

Agency’s level of concern, i.e., greater

than 100 percent of the RfD, Bayer Corp.

believes that actual exposure and risk

would be lower. The basis for this is

that the risk reflects a higher than actual

dietary exposure because it assumes that

100 percent of most commodities for

which cyfluthrin tolerances exist have

cyfluthrin residues and that all will bear

residue levels as high as the tolerances.

In reality, all these commodities will not

have residues of this pesticide and

actual levels will be lower than

tolerance levels. To assess the dietary

exposure from the establishment of the

proposed citrus tolerances, the

incremental increase in dietary

exposure was taken from the dietary

exposure analysis conducted by the

Agency. These estimates are based on

the assumption that 100 percent of the

citrus crop in the U.S. would be treated

with cyfluthrin. In reality, this use of

cyfluthrin will be limited to California

and Arizona only for the control of

citrus thrips. For the prior six years,

cyfluthrin has been utilized in the

California’s Central Valley under the

provisions of a FIFRA section 18

Emergency Exemption. In 1995,

approximately 77,000 out of 170,000

acres (46 percent) of the citrus grown in

Central Valley was treated with

cyfluthrin. Assuming that a similar

proportion of acreage, that is 46 percent,

would be treated throughout California

and Arizona, the total estimated acreage

treated with cyfluthrin would be 94,000

acres. This represents only 9.4 percent

of the 1,026,000 fruit bearing acres of

citrus grown in the U.S. Therefore, a 10

percent treated crop adjustment to the

dietary exposure can be considered

appropriate.

Adding this incremental exposure to

the current estimated dietary exposure

results in a total dietary exposure for the

U.S. population of 0.0094934 mg/kg

bwt/day representing 38 percent of RfD.

The highest exposure group, nonnursing infants will increase only very

slightly, to 0.253653 mg/kg bwt/day

representing 101.4 percent of the RfD.

As described above, although this still

slightly exceeds the RfD, actual

exposure is expected to be much less.

Generally speaking, EPA has no cause

for concern if the total dietary exposure

from residues for uses for which there

are published and proposed tolerances

is less than the RfD. Therefore Bayer

concludes that the chronic dietary risk

of cyfluthrin, as estimated by the dietary

risk assessment, does not appear to be

of concern.

Other potential sources of exposure to

residues of pesticides are residues in

drinking water and exposure from nonoccupational sources. Based on

available studies used in previous EPA

assessments, Bayer Corp. does not

anticipate exposures to cyfluthrin in

drinking water. Non-occupational

exposure to cyfluthrin may occur as a

result of inhalation or contact from

indoor residential, indoor commercial,

and outdoor residential uses. The

Agency does not currently have reliable

data to determine aggregate exposures

from these sources. However,

determinations of worst case exposure

from inhalation in indoor settings

(continuous exposure at saturation

vapor concentration) should indicate

that adequate margins of safety exist

even under these conditions. Since this

evaluation greatly overestimates

exposure, the contribution to aggregate

exposure from inhalation in normal uses

would be expected to be negligible.

Estimations of outdoor residential

exposure have been required for

cyfluthrin in a data call-in issued in

1995. These data are being generated by

the Outdoor Residential Exposure Task

Force (ORETF). However, available data

show that the acute dermal toxicity of

cyfluthrin is very low, with the LD50

being greater than 5,000 mg/kg, the

highest dose tested. Sub-acute (21–day)

dermal toxicity data showed only

localized (skin) effects at higher level

exposures (1,000 mg/kg/day and 340

mg/kg/day). Other than skin effects at

these high exposure levels, no effects

were observed at any exposure levels,

the highest level tested being 1,000 mg/

kg/day. The use rate for cyfluthrin on

residential turf is 1 g (1,000 mg) active

ingredient per 1000 square feet which

would indicate that potential exposures

would be well below levels tested. In

addition, the localized skin effects seen

at the prolonged higher exposures in

animal tests have not been reported for

non-occupational exposures to

cyfluthrin in currently accepted uses,
12184 Federal Register / Vol. 62, No. 50 / Friday, March 14, 1997 / Notices

indicating that exposures are below the

threshold of any observable effects.

Indoor uses are limited to areas with

little or no contact, so exposures would

be expected to be even less. Thus, the

dermal route of exposure does not

appear to be significant and the

contribution to aggregate exposure from

dermal contact would be expected to be

negligible.

In consideration of potential

cumulative effects of cyfluthrin and

other substances that have a common

mechanism of toxicity, there are

currently no available data or other

reliable information indicating that any

toxic effects produced by cyfluthrin

would be cumulative with those of other

chemical compounds; thus only the

potential risks of cyfluthrin have been

considered in this assessment of its

aggregate exposure.

D. Safety Determinations

1. U.S. population in general. Using

the conservative exposure assumptions

described above and based on the

completeness and reliability of the

toxicity data it can be concluded that

total aggregate exposure to cyfluthrin

from all current uses as well as the

proposed tolerance and maximum

residue levels for the use of cyfluthrin

on citrus will utilize little more than 38

percent of the RfD for the U.S.

population. EPA generally has no

concerns for exposures below 100

percent of the RfD, because the RfD

represents the level at or below which

daily aggregate exposure over a lifetime

will not pose appreciable risks to

human health. Thus, it can be

concluded that there is a reasonable

certainty that no harm will result from

aggregate exposure to cyfluthrin

residues.

2. Infants and children. In assessing

the potential for additional sensitivity of

infants and children to residues of

cyfluthrin, the data from developmental

studies in both rat and rabbit and a 2-

generation reproduction study in the rat

can be considered. The developmental

toxicity studies evaluate any potential

adverse effects on the developing

animal resulting from pesticide

exposure of the mother during prenatal

development . The reproduction study

evaluates any effects from exposure to

the pesticide on the reproductive

capability of mating animals through

two generations, as well as any observed

systemic toxicity.

The toxicology data cited in support

of the tolerance include: An oral

developmental toxicity study in rats

with a maternal and fetal NOEL of 10

mg/kg/day (highest dose tested). An oral

developmental toxicity study in rabbits

with a maternal NOEL of 20 mg/kg/day

and a maternal LEL of 60 mg/kg/day,

based on decreased body weight gain

and decreased food consumption during

the dosing period. A fetal NOEL of 20

mg/kg/day and a fetal LEL of 60 mg/kg/

day were also observed in this study.

The LEL was based on increased

resorptions and increased

postimplantation loss.

A developmental toxicity study in rats

by the inhalation route of

administration with a maternal NOEL of

0.0011 mg/l and a LEL of 0.0047 mg/l,

based on reduced mobility, dyspnea,

piloerection, ungroomed coats and eye

irritation. The fetal NOEL is 0.00059

mg/l and the fetal LEL is 0.0011 mg/l,

based on sternal anomalies and

increased incidence of runts. A second

developmental toxicity study in rats by

the inhalation route of administration

has been submitted to the Agency and

is currently under review.

A three-generation reproduction study

in rats with a systemic NOEL of 2.5 mg/

kg/day and a systemic LEL of 7.5 mg/

kg/day due to decreased parent and pup

body weights. The reproductive NOEL

and LEL are 7.5 mg/kg/day and 22.5 mg/

kg/day respectively.

The Agency used the rabbit

developmental toxicity study with a

maternal NOEL of 20 mg/kg/day to

assess acute dietary exposure and

determine a margin of exposure (MOE)

for the overall U.S. population and

certain subgroups. Since this

toxicological endpoint pertains to

developmental toxicity the population

group of concern for this analysis was

women aged 13 and above, the subgroup

which most closely approximates

women of child-bearing age. The MOE

is calculated as the ration of the NOEL

to the exposure. For this analysis the

Agency calculated the MOE to be over

600. Generally, MOE’s greater than 100

for data derived from animal studies are

regarded as showing no appreciable

risk.

FFDCA Section 408 provides that EPA

may apply an additional safety factor for

infants and children in the case of

threshold effects to account for pre- and

post-natal effects and the completeness

of the toxicity database. Based on

current toxicological data requirements,

the toxicology database for cyfluthrin

relative to pre- and post-natal effects is

complete. The no-effect-levels observed

in the developmental and reproduction

study are equivalent or higher than the

NOEL from the 2-year rat feeding study,

used with a 100 fold uncertainty factor

to establish the reference dose.

Therefore, an additional uncertainty

factor is not warranted and that the RfD

at 0.025 mg/kg/day is appropriate for

assessing aggregate risk to infants and

children.

Using the conservative exposure

assumptions described above, EPA has

previously concluded that the residues

from use of cyfluthrin on citrus will

contribute the highest incremental

increase to the aggregate exposure to the

population subgroup children 1 to 6

years old, accounting for 3.9 percent of

the RfD and giving a total dietary

exposure from all uses of 95.9 percent

of the RfD for this subgroup. However,

this assessment was based on an

assumption of 100 percent crop treated.

When adjusted for a 10 percent crop

treatment (as described in section B.

above) the incremental exposure is

negligible, increasing form the current

0.022985 mg/kg bwt /day (91.9 percent

of the RfD) to 0.231522 mg /kg bwt/day

or 92.6 percent of the RfD. For nursing

infants current exposure is 0.005692

mg/kg bwt/day or 22.8 percent of the

RfD. The use on citrus would increase

exposure to 0.0057377 mg/kg bwt/day

representing 22.9 percent of the RfD. For

children 7 to 12, current exposure is

0.015237 mg/kg bwt/ day, 60.9 percent

of the RfD. The use on citrus would

increase this to 0.153416 mg/kg bwt

/day, or 61.4 percent of the RfD. For

non-nursing infants, the current is

exposure is calculated to be 0.025267

mg/kg bwt /day, 101 percent of the RfD.

The use on citrus would increase this

slightly to 0.0253653 or 101.4 percent.

Both the current and the resulting

calculated exposure from adding the

estimated exposure from citrus exposure

are slightly higher than the Agency’s

level of concern. However, the Agency

has previously assessed this risk in the

evaluation of PP 2F4137 and believed

the actual exposure and risk would be

much lower. The basis for this was the

fact that this calculated exposure

assumes, with the exception of citrus,

that 100 percent of the commodities for

which cyfluthrin tolerance exists have

residues and that the residues all bear

residues as high as the tolerance levels.

In reality, it is known that not all

commodities will have cyfluthrin

residues and actual levels will be lower

than the tolerance values. In addition,

the food commodity that contributes

most to this slight exceedence is milk,

at 88.2 percent of the RfD; 71.2 percent

from milk fat and 17 percent from whole

milk and milk sugars. However,

metabolism data indicate that

essentially all of the cyfluthrin will

concentrate in milk fat and there would

be negligible amounts in other

components. Thus the 17 percent

contribution from non-milk fat portions

of milk is an overestimation of actual
Federal Register / Vol. 62, No. 50 / Friday, March 14, 1997 / Notices 12185

exposure, which would be below the

RfD.

Generally, EPA has no cause for

concern if the total aggregate exposure

is less than the RfD, therefore it may be

concluded that there is a reasonable

certainty of no harm will result to

infants and children.

E. Conclusions

The available data indicate that there

is reasonable certainty of no harm from

the incremental exposure resulting from

the potential residues of cyfluthrin from

the use of Baythroid 2, EPA Reg. No.

3125–351, on citrus. Thus in accordance

with the provisions of the FFDCA as

amended August 3, 1996, regulations to

establish the tolerance and maximum

residue levels to support this use can be

effected.

F. International Tolerances

There are no Codex maximum residue

levels (MRLs) established for residues

ofcyfluthrin on citrus fruits or any

resulting processed products.

II. Public Record

Interested persons are invited to

submit comments on this notice of

filing. Comments must bear a notation

indicating the docket control number,

[PF–717]. All written comments filed in

response to this petition will be

available in the Public Response and

Program Resources Branch, at the

address given above from 8:30 a.m. to 4

p.m., Monday through Friday, except

legal holidays.

A record has been established for this

notice under docket control number

[PF–717] including comments and data

submitted electronically as described

below). A public version of this record,

including printed, paper versions of

electronic comments, which does not

include any information claimed as CBI,

is available for inspection from 8:30

a.m. to 4 p.m., Monday through Friday,

excluding legal holidays. The public

record is located in Rm. 1132 of the

Public Response and Program Resources

Branch, Field Operations Division

(7506C), Office of Pesticide Programs,

Environmental Protection Agency,

Crystal Mall #2, 1921 Jefferson Davis

Highway, Arlington, VA.

Electronic comments can be sent

directly to EPA at:

opp-docket@epamail.epa.gov

Electronic comments must be

submitted as ASCII file avoiding the use

of special characters and any form of

encryption.

The official record for this notice, as

well as the public version, as described

above will be kept in paper form.

Accordingly, EPA will transfer all

comments received electronically into

printed, paper form as they are received

and will place the paper copies in the

official record which will also include

all comments submitted directly in

writing. The official record is the paper

record maintained at the address in

‘‘ADDRESSES’’ at the beginning of this

document.

Authority: 21 U.S.C. 346a.

List of Subjects

Environmental Protection,

Administrative practice and procedure,

Agricultural commodities, Pesticides

and pests, Reporting and recordkeeping

requirements.

Dated: March 7, 1997.

Stephen L. Johnson,

Director, Registration Division, Office of

Pesticide Programs.

[FR Doc. 97–6516 Filed 3–13–97; 8:45 am]

BILLING CODE 6560–50–F

[OPP–50826; FRL–5592–3]

Issuance of an Experimental Use

Permit

AGENCY: Environmental Protection

Agency (EPA).

ACTION: Notice.

SUMMARY: EPA has granted an

experimental use permit to the

following applicant. The permit is in

accordance with, and subject to, the

provisions of 40 CFR part l72, which

defines EPA procedures with respect to

the use of pesticides for experimental

use purposes.

FOR FURTHER INFORMATION CONTACT: By

mail: Mike Mendelsohn, Office of

Pesticide Programs, Biopesticides and

Pollution Prevention Division (7501W),

Environmental Protection Agency, 401

M St., SW., Washington, DC 20460. In

person or by telephone: Rm. 3142, CM

#2, 1921 Jefferson Davis Highway,

Arlington, VA, Telephone: 703–308–

8715, e-mail:

mendelsohn.mike@epamail.epa.gov.

SUPPLEMENTARY INFORMATION: EPA has

issued the following experimental use

permit: 70218–EUP–1. Issuance. This

experimental use permit allows the use

of 0.825 pounds of the Bacillus

thuringiensis subspecies tolworthi

Cry9C protein in seeds shipped on 3,305

acres of corn to evaluate the control of

the European corn borer and other

lepidopteran corn pests. The program is

authorized in the States of Alabama,

California, Colorado, Delaware, Florida,

Georgia, Hawaii, Illinois, Indiana, Iowa,

Kansas, Kentucky, Louisiana, Maryland,

Michigan, Minnesota, Mississippi,

Missouri, Nebraska, New York, North

Carolina, Ohio, Pennsylvania, Puerto

Rico, South Dakota, Tennessee, Texas,

Virginia, and Wisconsin. The

experimental use permit is effective

from February 5, 1997 to November 30,

1997. This permit is issued with the

limitation that all treated crops are

destroyed or used for research purposes

only.

Persons wishing to review this

experimental use permit are referred to

the designated contact person. Inquires

concerning this permit should be

directed to the person cited above. It is

suggested that interested persons call

before visiting the EPA office, so that

the appropriate file may be made

available for inspection purposes from 8

a.m. to 4 p.m., Monday through Friday,

excluding legal holidays.

Authority: 7 U.S.C. 136.

List of Subjects

Environmental protection,

Experimental use permits.

Dated: March 5, 1997.

Janet L. Andersen,

Director, Biopesticides and Pollution

Prevention Division, Office of Pesticide

Programs.

[FR Doc. 97–6518 Filed 3–13–97; 8:45 am]

BILLING CODE 6560–50–F

[FRL–5710–4]

Special Report on Environmental

Endocrine Disruption: An Effects

Assessment and Analysis

AGENCY: Environmental Protection

Agency (EPA).

ACTION: Notice of availability of risk

assessment forum report.

SUMMARY: EPA is announcing the

availability of the ‘‘Special Report on

Environmental Endocrine Disruption:

An Effects Assessment and Analysis.’’

The report provides an overview of the

current state of the science for

endocrine disruption. The report’s

major components are an introduction

to the endocrine system and the

endocrine disruption hypothesis; a

review of potential human health and

ecological risks; and an analysis section,

including an overview of research

needs. The report represents an interim

assessment pending a more extensive

review expected to be issued by the

National Academy of Sciences later in

1997.

ADDRESSES: An electronic version of the

report is accessible on EPA’s Office of