Exhibit 10.100

AMENDMENT NO. 2 TO INTELLECTUAL PROPERTY SECURITY AGREEMENT

This AMENDMENT NO. 2 is made as of the 11th day of July, 2002 (the "Amendment") by and between Kevin Kimberlin Partners, L.P., a Delaware limited partnership
("KKP"), The Immune Response Corporation, a Delaware corporation ("Seller"), Oshkim Limited Partnership ("Oshkim"), and The Kimberlin Family 1998 Irrevocable Trust (the "Trust").

WHEREAS,
the Seller and the KKP entered into that certain Intellectual Property Agreement, dated as of November 9, 2001, as amended by Amendment No. 1 to Intellectual
Property Security Agreement, dated as of February 14, 2002, by and between KKP, Seller and Oshkim (the "IP Agreement").

WHEREAS,
the Seller proposes to issue and sell Additional Securities (as defined in that certain Note Purchase Agreement, dated November 9, 2001, by and between KKP and Seller and
as amended) to the Trust and the Trust wishes to purchase Additional Securities from Seller.

WHEREAS,
the parties desire to amend the IP Agreement to add the Trust and any affiliates of KKP, Oshkim and/or the Trust as parties and in certain other respects as set forth below.

NOW,
THEREFORE, in consideration of the foregoing premises and the mutual covenants set forth below, the parties hereby amend the IP Agreement and agree as follows:

1.    Effective
as of the date of this Amendment, the IP Agreement is hereby amended as follows:



2.    Except
as specifically provided herein, the IP Agreement, as originally executed by the parties thereto and as amended hereby, shall remain in full force and effect.

3.    Any
defined terms not defined herein shall have the respective meanings set forth in the IP Agreement.

4.    This
Amendment may be executed in counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument.

5.    This
Amendment shall be governed by and construed in accordance with the internal laws of the State of New York applicable to agreements made and to be performed entirely
within such jurisdiction.

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IN
WITNESS WHEREOF, the parties hereto have executed this Amendment as of the date first above written.

| |  | KEVIN KIMBERLIN PARTNERS, L.P.             
| |  | -------------------------------------------
| |  |                                            
| |  | By:                                        
| |  |                                            
| |  |                                            
| |  |                                            
| |  |                                            
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| |  |                                            
| |  | OSHKIM LIMITED PARTNERSHIP                 
| |  |                                            
| |  | By:                                        
| |  |                                            
| |  |                                            
| |  |                                            
| |  |                                            
| |  |                                            
| |  |                                            
| |  | THE KIMBERLIN FAMILY 1998 IRREVOCABLE TRUST
| |  |                                            
| |  | By:                                        
| |  |                                            
| |  |                                            
| |  |                                            
| |  |                                            
| |  |                                            
| |  |                                            
| |  | THE IMMUNE RESPONSE CORPORATION            
| |  |                                            
| |  | By:                                        
| |  |                                            
| |  |                                            
| |  |                                            
| |  |                                            
| |  |                                            

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