|Exhibit 10.89
|-------------



|THE IMMUNE RESPONSE CORPORATION 8% SECURED PROMISSORY NOTE
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|$2,000,000 | New York, New York
      March 20, 2002
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|FOR
      VALUE RECEIVED, the undersigned, The Immune Response Corporation, a Delaware
      corporation (the Issuer), hereby unconditionally promises to
      pay to the order of Oshkim Limited Partnership, a Delaware limited partnership
      (the Purchaser), at the office of the Purchaser located at 535
      Madison Avenue, 18th Floor, New York, New York 10022, or such other address
      designated by the Purchaser, in lawful money of the United States of America
      and in immediately available funds, on May 5, 2002 (the Note Maturity
      Date) the principal amount of Two Million Dollars ($2,000,000) and
      accrued interest at the rate of eight (8%) percent per annum based on a
      365-day year (Interest Rate).
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|Interest
      (other than interest accruing as a result of a failure by Issuer to pay
      any amount when due as set forth below) in respect of the Note shall accrue
      until all amounts remaining owed under such Note shall be fully repaid,
      and shall be payable in full on the Note Maturity Date. If all or a portion
      of the principal amount of the Note or any interest payable thereon shall
      not be repaid when due whether on the applicable repayment date, by acceleration
      or otherwise, such overdue amounts on such Note shall bear interest at a
      rate per annum that is three (3%) percent above the Interest Rate (i.e.,
      11%) from the date of such non-payment until such amount is paid in full
      (after as well as before judgment). All payments to be made by Issuer hereunder
      or pursuant to the Notes shall be made in lawful money of the United States
      by certified check or wire transfer in immediately available funds. Any
      interest accruing on overdue amounts shall be payable on demand.
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|The
      obligations to make the payments provided for in this Note are absolute
      and unconditional, and are not subject to any defense, set-off, counterclaim,
      rescission, recoupment or adjustment whatsoever.
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|The
      obligations under this Note shall be secured by that certain Intellectual
      Property Security Agreement, dated November 9, 2001, executed by the Issuer
      and as amended February 26, 2002).
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|Upon
      the occurrence of any one or more of the Events of Default specified on
      Exhibit A, attached hereto, all amounts then remaining unpaid on
      this Note shall become, or may be declared by the Purchaser to be, immediately
      due and payable.
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|This
      Note is freely transferable, in whole or in part, by the Purchaser, and
      such transferee shall have the same rights hereunder as the Purchaser. The
      Issuer may not assign or delegate any of its obligations under this Note
      without the prior written consent of the Purchaser (or its successor, transferee
      or assignee).
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|All
      parties now and hereafter liable with respect to this Note, whether maker,
      principal, surety, guarantor, endorser or otherwise, hereby waive presentment,
      demand, protest and all other notices of any kind.
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|The
      Issuer agrees to pay all of the Purchasers expenses, including reasonable
      attorneys costs and fees, incurred in collecting sums due under this
      Note.
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|All
      or part of the Note may be prepaid by Issuer following receipt by Purchaser
      of written notice thereof from Issuer; provided, however, that any such
      prepayment on such Note shall be first applied to accrued and unpaid interest
      of the outstanding Note and then against its outstanding principal.
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|In
      the event that from the date hereof until the Note Maturity Date the Purchaser,
      or an affiliate of the Purchaser, shall loan additional monies to the Issuer
      all such proceeds shall promptly be used to repay this Note and interest
      hereon.
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|This
      Note shall be governed by, and construed and interpreted in accordance with,
      the laws of the State of New York.
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| | THE IMMUNE RESPONSE CORPORATION
      By: ______________________________
| | ------------------------------------------------------------------------

| | Name: _________________________
      Title:  __________________________
| | ------------------------------------------------------------------------



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