EX-10.6





 Certain confidential information contained in this document, marked by [**], has been
omitted 
 because SOPHiA GENETICS SA (SOPHiA) has determined that the information (i) is not material 

and (ii) is the type that SOPHiA customarily and actually treats as private or confidential. 

Exhibit 10.6 
 AMENDMENT
NO.1 TO A MANUFACTURING AND SUPPLY AGREEMENT 
  

			
		
	BETWEEN:	  	SOPHiA GENETICS S.A., a corporation established under the laws of Switzerland, registered at the Swiss Companies Registration Office under number
CH-550.1.086.569-3, whose registered office is at Rue du Centre 172, CH-1025 Saint-Sulpice, Switzerland,
		
		  	(hereinafter referred to as “SOPHiA”)
		
	AND:	  	INTEGRATED DNA TECHNOLOGIES, INC., a corporation established under the laws of Delaware with a place of business at [**],
		
		  	(hereinafter referred to as “IDT”)

 RECITALS 

WHEREAS The Parties entered into an “Amended and Restated Manufacturing and Supply Agreement” on October 9th, 2018 (the “Main Agreement”); 
 WHEREAS, IDT agrees to provide additional
warranties with regard to the shelf-life of a Commercial Product, as such term is defined in the Main Agreement 
 WHEREAS the Parties wish to
witness their agreement in writing; 
 CONSEQUENTLY, FOR GOOD AND VALUABLE CONSIDERATION, THE PARTIES AGREE TO MODIFY THE AGREEMENT IN GOOD FAITH AS
FOLLOWS: 
  

	1.	 RECITALS 



The recitals shall be construed as part of this Amendment. 
  

	2.	 AMENDED PROVISION 



As of the date of the last signature of this Amendment by the Parties, the Parties hereby agree to modify the Main Agreement by adding a
subsection 3.5 immediately following subsection 3.4 of the Main Agreement, which shall read as follows: 
 “IDT represents and
warrants the Commercial Products delivered under this Agreement shall have a shelf-life of [**] (i.e., an “expiration date”) from the date where they are delivered to Sophia. Sophia shall be entitled to reject Products that do not comply
with this provision, and IDT shall replace any such rejected Product promptly with compliant Products.” 













	3.	 NON-AMENDED PROVISIONS 



Any provision that is not expressly modified or mentioned by this Addendum shall remain in force and apply mutatis mutandis between the
Parties. 
 (Signature page follows) 

Certain confidential information contained in this document, marked by [**], has been omitted because SOPHiA GENETICS SA (SOPHiA) has
determined that the information (i) is not material and (ii) is the type that SOPHiA customarily and actually 
 treats as
private or confidential. 












 IN WITNESS WHEREOF, THE PARTIES HAVE AGREED TO SIGN THIS AGREEMENT AS FOLLOWS: 

 

											
	SOPHiA GENETICS S.A.	  	IDT, INC.
				
	By:	 	 /s/ Damien Lapray
	  	By:	 	 /s/ Todd E. McManus

		 	Name:	 	Damien Lapray	  		 	Name:	 	Todd E. McManus
		 	Title: 	 	CCO	  		 	Title: 	 	General Counsel
		 	Date: 	 	5/4/2019	  		 	Date: 	 	4 March 2019
				
	By:	 	 /s/ Valentin Matillon
	  	By:	 	  

		 	Name:	 	Valentin Matillon	  		 	Name:	 	
		 	Title: 	 	CFO	  		 	Title:	 	
		 	Date: 	 	5/4/2019	  		 	Date:	 	

 Certain confidential information contained in this document, marked by [**], has been omitted because SOPHiA
GENETICS SA (SOPHiA) has determined that the information (i) is not material and (ii) is the type that SOPHiA customarily and actually 

treats as private or confidential.