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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549





FORM 10-Q







|x | Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
|- | ---------------------------------------------------------------------------------------

For the quarterly period ended June 30, 2010

OR



| ̈ | Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
|- | ----------------------------------------------------------------------------------------

For the transition period from              to

Commission File Number 001-33221





A.P. PHARMA, INC.

(Exact name of registrant as specified in its charter)







|                                              |  |                                    
|--------------------------------------------- |  | -----------------------------------
|Delaware                                      |  | 94-2875566                         
|(State or other jurisdictionof incorporation) |  | (I.R.S. EmployerIdentification No.)
|                                              | 
|123 Saginaw Drive Redwood City CA             |  | 94063                              
|(Address of principal executive offices)      |  | (Zip Code)                         

(650)
366-2626

(Registrants telephone number, including area code)





Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15 (d) of the Securities
Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90
days.    Yes  x    No   ̈

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File
required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such
files).    Yes   ̈    No   ̈

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer or a smaller reporting company.
See definition of large accelerated filer, accelerated filer and smaller reporting company in Rule 12b-2 of the Exchange Act.



|                        |  |   |  |                         |  |  
|----------------------- |  | - |  | ----------------------- |  | -
|Large accelerated filer |  |  ̈ |  | Accelerated filer       |  |  ̈
|                        |  |   | 
|Non-accelerated filer   |  |  ̈ |  | Small reporting company |  | x

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange
Act.)    Yes   ̈    No  x

At July 31, 2010, the number of outstanding shares of the Companys common stock, par value $.01, was 40,114,210.









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##### Table of Contents

Table of Contents

A.P. Pharma, Inc

INDEX



|         |  |                                                                                              |  |         
|-------- |  | -------------------------------------------------------------------------------------------- |  | --------
|         |  |                                                                                              |  | Page No.
|PART I.  |  | FINANCIAL INFORMATION                                                                        |  |         
|         |  |                                                                                             
|Item 1.  |  | Financial Statements (unaudited):                                                            |  |         
|         |  |                                                                                             
|         |  | Condensed Balance Sheets as of June 30, 2010 and December 31, 2009                           |  | 3       
|         |  |                                                                                             
|         |  | Condensed Statements of Operations for the three and six months ended June 30, 2010 and
2009 |  | 4       
|         |  |                                                                                             
|         |  | Condensed Statements of Cash Flows for the six months ended June 30, 2010 and 2009           |  | 5       
|         |  |                                                                                             
|         |  | Notes to Condensed Financial Statements                                                      |  | 6       
|         |  |                                                                                             
|Item 2.  |  | Managements Discussion and Analysis of Financial Condition and Results of
Operations        |  | 13      
|         |  |                                                                                             
|Item 3.  |  | Quantitative and Qualitative Disclosures about Market Risk                                   |  | 17      
|         |  |                                                                                             
|Item 4.  |  | Controls and Procedures                                                                      |  | 17      
|         |  |                                                                                             
|PART II. |  | OTHER INFORMATION                                                                            |  | 17      
|         |  |                                                                                             
|Item 1.  |  | Legal Proceedings                                                                            |  | 17      
|         |  |                                                                                             
|Item 1A  |  | Risk Factors                                                                                 |  | 17      
|         |  |                                                                                             
|Item 6.  |  | Exhibits                                                                                     |  | 21      
|         |  |                                                                                             
|         |  | Signatures                                                                                   |  | 22      



2



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##### Table of Contents

PART I. Financial Information



|Item 1: | Financial Statements:
|------- | ---------------------

A.P. Pharma, Inc.

Condensed Balance Sheets

(in thousands)



|                                           |  |               |          |   |                   |   |          |  
|------------------------------------------ |  | ------------- | -------- | - | ----------------- | - | -------- | -
|                                           |  | June 30, 2010 |          |   | December 31, 2009 |  
|                                           |  | (unaudited)   |          |   | (Note 1)          |  
|Assets                                     |  |               |          |   |                   |   |          |  
|Current assets:                            |  |               |          |   |                   |   |          |  
|Cash and cash equivalents                  |  | $             | 5,736    |   |                   | $ | 7,593    |  
|Accounts receivable                        |  |               | 356      |   |                   |   | 171      |  
|Prepaid expenses and other current assets  |  |               | 308      |   |                   |   | 549      |  
|                                           |  |               |          |   |                   |   |          |  
|Total current assets                       |  |               | 6,400    |   |                   |   | 8,313    |  
|                                           |  |              
|Property and equipment, net                |  |               | 399      |   |                   |   | 510      |  
|Other long-term assets                     |  |               | 53       |   |                   |   | 128      |  
|                                           |  |               |          |   |                   |   |          |  
|Total assets                               |  | $             | 6,852    |   |                   | $ | 8,951    |  
|                                           |  |               |          |   |                   |   |          |  
|                                           |  |              
|Liabilities and Stockholders Equity       |  |               |          |   |                   |   |          |  
|Current liabilities:                       |  |               |          |   |                   |   |          |  
|Accounts payable                           |  | $             | 128      |   |                   | $ | 162      |  
|Accrued compensation                       |  |               | 1,192    |   |                   |   | 367      |  
|Accrued expenses                           |  |               | 653      |   |                   |   | 713      |  
|Deferred revenue                           |  |               | 112      |   |                   |   | 92       |  
|Accrued disposition costs                  |  |               | 565      |   |                   |   | 553      |  
|                                           |  |               |          |   |                   |   |          |  
|Total current liabilities                  |  |               | 2,650    |   |                   |   | 1,887    |  
|Deferred revenue                           |  |               | 196      |   |                   |   | 268      |  
|                                           |  |               |          |   |                   |   |          |  
|Total liabilities                          |  |               | 2,846    |   |                   |   | 2,155    |  
|                                           |  |               |          |   |                   |   |          |  
|                                           |  |              
|Stockholders equity:                      |  |               |          |   |                   |   |          |  
|Common stock                               |  |               | 401      |   |                   |   | 394      |  
|Additional paid-in capital                 |  |               | 148,762  |   |                   |   | 147,481  |  
|Accumulated deficit                        |  |               | (145,157 | ) |                   |   | (141,079 | )
|                                           |  |               |          |   |                   |   |          |  
|Total stockholders equity                 |  |               | 4,006    |   |                   |   | 6,796    |  
|                                           |  |               |          |   |                   |   |          |  
|Total liabilities and stockholders equity |  | $             | 6,852    |   |                   | $ | 8,951    |  
|                                           |  |               |          |   |                   |   |          |  

See accompanying notes to condensed financial statements.



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##### Table of Contents

A.P. Pharma, Inc.

Condensed Statements of Operations

(in thousands, except per share amounts)

(unaudited)



|                                                            |  |                            |        |   |                          |   |        |      |  |   |        |   |  |   |        |  
|----------------------------------------------------------- |  | -------------------------- | ------ | - | ------------------------ | - | ------ | ---- |  | - | ------ | - |  | - | ------ | -
|                                                            |  | Three Months EndedJune 30, |        |   | Six Months EndedJune 30, |  
|                                                            |  | 2010                       |        |   | 2009                     |   |        | 2010 |  |   | 2009   |  
|Contract revenue                                            |  | $                          | 530    |   |                          | $ | 14     |      |  | $ | 771    |   |  | $ | 22     |  
|                                                            |  |                            |        |   |                          |   |        |      |  |   |        |   |  |   |        |  
|                                                            |  |                            |        |  
|Operating expenses:                                         |  |                            |        |   |                          |   |        |      |  |   |        |   |  |   |        |  
|Research and development                                    |  |                            | 1,890  |   |                          |   | 2,908  |      |  |   | 4,221  |   |  |   | 4,958  |  
|                                                            |  |                            |        |  
|General and administrative                                  |  |                            | 2,335  |   |                          |   | 1,066  |      |  |   | 3,116  |   |  |   | 1,993  |  
|                                                            |  |                            |        |   |                          |   |        |      |  |   |        |   |  |   |        |  
|Total operating expenses                                    |  |                            | 4,225  |   |                          |   | 3,974  |      |  |   | 7,337  |   |  |   | 6,951  |  
|                                                            |  |                            |        |   |                          |   |        |      |  |   |        |   |  |   |        |  
|                                                            |  |                            |        |  
|Operating loss                                              |  |                            | (3,695 | ) |                          |   | (3,960 | )    |  |   | (6,566 | ) |  |   | (6,929 | )
|                                                            |  |                            |        |  
|Gain on sale of royalty interest                            |  |                            |       |   |                          |   |       |      |  |   | 2,500  |   |  |   |       |  
|Interest income, net                                        |  |                            |       |   |                          |   | 19     |      |  |   |       |   |  |   | 28     |  
|                                                            |  |                            |        |   |                          |   |        |      |  |   |        |   |  |   |        |  
|Loss from continuing operations                             |  |                            | (3,695 | ) |                          |   | (3,941 | )    |  |   | (4,066 | ) |  |   | (6,901 | )
|Income (loss) from discontinued operations                  |  |                            | 112    |   |                          |   |       |      |  |   | (12    | ) |  |   |       |  
|                                                            |  |                            |        |   |                          |   |        |      |  |   |        |   |  |   |        |  
|Net loss                                                    |  | $                          | (3,583 | ) |                          | $ | (3,941 | )    |  | $ | (4,078 | ) |  | $ | (6,901 | )
|                                                            |  |                            |        |   |                          |   |        |      |  |   |        |   |  |   |        |  
|                                                            |  |                            |        |  
|Basic and diluted net loss per share:                       |  |                            |        |   |                          |   |        |      |  |   |        |   |  |   |        |  
|Loss from continuing operations                             |  | $                          | (0.09  | ) |                          | $ | (0.13  | )    |  | $ | (0.10  | ) |  | $ | (0.22  | )
|                                                            |  |                            |        |   |                          |   |        |      |  |   |        |   |  |   |        |  
|Net loss                                                    |  | $                          | (0.09  | ) |                          | $ | (0.13  | )    |  | $ | (0.10  | ) |  | $ | (0.22  | )
|                                                            |  |                            |        |   |                          |   |        |      |  |   |        |   |  |   |        |  
|                                                            |  |                            |        |  
|Shares used to compute basic and diluted net loss per share |  |                            | 39,493 |   |                          |   | 31,016 |      |  |   | 39,470 |   |  |   | 30,943 |  
|                                                            |  |                            |        |   |                          |   |        |      |  |   |        |   |  |   |        |  

See accompanying notes to condensed financial statements.



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A.P. Pharma, Inc.

Condensed Statements of Cash Flows

(in thousands)

(unaudited)



|                                                                            |  |                           |        |   |      |   |        |  
|--------------------------------------------------------------------------- |  | ------------------------- | ------ | - | ---- | - | ------ | -
|                                                                            |  | Six Months Ended June 30, |       
|                                                                            |  | 2010                      |        |   | 2009 |  
|Cash flows from operating activities:                                       |  |                           |        |   |      |   |        |  
|Net loss                                                                    |  | $                         | (4,078 | ) |      | $ | (6,901 | )
|Adjustments to reconcile net loss to net cash used in operating activities: |  |                           |        |   |      |   |        |  
|Loss from discontinued operations                                           |  |                           | 12     |   |      |   |       |  
|Depreciation and amortization                                               |  |                           | 123    |   |      |   | 182    |  
|Stock-based compensation expense                                            |  |                           | 1,188  |   |      |   | 620    |  
|Loss on retirement of fixed asset                                           |  |                           |       |   |      |   | 17     |  
|Changes in operating assets and liabilities:                                |  |                           |        |   |      |   |        |  
|Accounts receivable                                                         |  |                           | (185   | ) |      |   | 21     |  
|Prepaid expenses and other current assets                                   |  |                           | 241    |   |      |   | 81     |  
|Other long-term assets                                                      |  |                           | 75     |   |      |   | (25    | )
|Accounts payable                                                            |  |                           | (34    | ) |      |   | 211    |  
|Accrued compensation                                                        |  |                           | 825    |   |      |   | (38    | )
|Accrued expenses                                                            |  |                           | (20    | ) |      |   | (961   | )
|Deferred revenue                                                            |  |                           | (52    | ) |      |   |       |  
|                                                                            |  |                           |        |   |      |   |        |  
|Net cash used in continuing operating activities                            |  |                           | (1,905 | ) |      |   | (6,793 | )
|                                                                            |  |                          
|Net cash provided by discontinued operations                                |  |                           |       |   |      |   |       |  
|                                                                            |  |                           |        |   |      |   |        |  
|Net cash used in operating activities                                       |  |                           | (1,905 | ) |      |   | (6,793 | )
|                                                                            |  |                           |        |   |      |   |        |  
|                                                                            |  |                          
|Cash flows from investing activities:                                       |  |                           |        |   |      |   |        |  
|Purchases of property and equipment                                         |  |                           | (12    | ) |      |   | (2     | )
|Maturities of marketable securities                                         |  |                           |       |   |      |   | 414    |  
|                                                                            |  |                           |        |   |      |   |        |  
|Net cash provided by (used in) investing activities                         |  |                           | (12    | ) |      |   | 412    |  
|                                                                            |  |                           |        |   |      |   |        |  
|                                                                            |  |                          
|Cash flows from financing activities:                                       |  |                           |        |   |      |   |        |  
|Proceeds from the exercise of stock options                                 |  |                           | 42     |   |      |   | 4      |  
|Proceeds from the issuance of shares under the Employee Stock Purchase Plan |  |                           | 18     |   |      |   | 23     |  
|Repurchase of restricted stock                                              |  |                           |       |   |      |   | (3     | )
|                                                                            |  |                           |        |   |      |   |        |  
|Net cash provided by financing activities                                   |  |                           | 60     |   |      |   | 24     |  
|                                                                            |  |                           |        |   |      |   |        |  
|                                                                            |  |                          
|Net decrease in cash and cash equivalents                                   |  |                           | (1,857 | ) |      |   | (6,357 | )
|Cash and cash equivalents, beginning of the period                          |  |                           | 7,593  |   |      |   | 9,967  |  
|                                                                            |  |                           |        |   |      |   |        |  
|Cash and cash equivalents, end of the period                                |  | $                         | 5,736  |   |      | $ | 3,610  |  
|                                                                            |  |                           |        |   |      |   |        |  

See accompanying notes to condensed financial statements.



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A.P. Pharma, Inc.

Notes to Condensed Financial Statements

June 30, 2010 and 2009 (unaudited)

(1) BUSINESS AND BASIS OF PRESENTATION

A.P. Pharma, Inc. (the Company, we, us and our) is a specialty pharmaceutical company focused on
developing products using our proprietary Biochronomer polymer-based drug delivery technology designed to release drugs over a defined period of time. Our primary focus is on our lead product candidate, APF530, which is being developed for the
prevention of chemotherapy-induced nausea and vomiting (CINV). In May 2009, we filed a New Drug Application (NDA) with the U.S. Federal Drug Administration (FDA) seeking approval for APF530. In March 2010, we received a Complete Response Letter to
the APF530 NDA and we intend to respond to the issues in the Complete Response Letter in as timely and expeditious a manner as possible. We intend to discuss some of the issues with the FDA at an End of Review meeting prior to resubmitting the
APF530 NDA. A date for this meeting has not been set. If we obtain regulatory approval for APF530, we intend to seek a collaborative arrangement to commercialize APF530, or anticipate obtaining additional funding and resources that would be required
to launch APF530 without a partner.

In addition to APF530, we have a pipeline of other product candidates that use our Biochronomer
technology. One product candidate, an undisclosed opiate for a long-acting pain management product, has been licensed on a world-wide basis to Merial Limited (Merial) for use with companion animals. Further development of our pipeline products has
been temporarily deferred in order to focus managerial, technical and financial resources on a resubmission responsive to issues identified in the March 2010 Complete Response Letter.

The accompanying unaudited condensed financial statements have been prepared in accordance with U.S. generally accepted accounting principles (U.S. GAAP)
for interim financial information and with the instructions to Form 10-Q and Article 10 of Regulation S-X. Accordingly, they do not include all of the information and footnotes required by U.S. GAAP for complete financial statements. All
adjustments (all of which are of a normal recurring nature) considered necessary for a fair presentation have been included. We have evaluated subsequent events through the date that these financial statements were issued. Operating results for
the three and six months ended June 30, 2010 are not indicative of the results that may be expected for the year ending December 31, 2010 or for any other period. The condensed balance sheet as of December 31, 2009 has been
derived from the audited financial statements as of that date but it does not include all of the information and notes required by U.S. GAAP. These condensed financial statements and the notes thereto should be read in conjunction with the
audited financial statements and notes thereto included in our Annual Report on Form 10-K for the year ended December 31, 2009 filed with the Securities and Exchange Commission (the SEC) on March 15, 2010 (our 2009
10-K).

Going Concern Considerations

The accompanying financial statements have been prepared assuming we will continue as a going concern. We have incurred significant operating losses and
negative cash flows from operations and have an accumulated deficit of $145.2 million as of June 30, 2010.

At June 30, 2010, we had
cash and cash equivalents of $5.7 million and working capital of $3.8 million. Presently, we do not have sufficient cash resources to meet our cash requirements beyond the fourth quarter of 2010. These factors raise substantial doubt about our
ability to continue as a going concern.

In March 2010, we received a Complete Response Letter for our APF530 NDA. In the letter, the FDA
raised questions which preclude the approval of the APF530 NDA in its current form. The full extent of activities, costs and time required to address the FDAs questions is not currently known, however, we expect to clarify the actions required
for resubmission and approval of our NDA at an End of Review meeting. Until we meet with the FDA and clarify the actions we need to take prior to resubmitting the NDA for APF530, we will not know how much additional cash may be required for approval
of APF530.



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A.P. Pharma, Inc.

Notes to Condensed Financial Statements(Continued)

June 30, 2010 and 2009 (unaudited)



We expect current capital resources to allow us to operate through the fourth quarter of 2010 since we
continue to defer certain discretionary activities. We will require additional capital to fund our drug development and operating activities and will seek additional financing to continue our activities, which may include a collaborative
arrangement, an equity offering or debt financing. If we are unable to complete such a financing or are unable to obtain sufficient financing on acceptable terms or otherwise, due to various factors including our ability to continue trading on the
Nasdaq Capital Market, we may be required to further reduce, defer or discontinue our activities or may not be able to continue as a going concern.

Critical Accounting Policies and Estimates

The preparation of financial statements in conformity with U.S. GAAP requires our management to make estimates and assumptions about future events that
affect the amounts reported in the financial statements and accompanying notes. Actual results could differ materially from those estimates. On an on-going basis, we evaluate our critical accounting policies and estimates. We base our estimates on
historical experience and on various other assumptions that we believe to be reasonable under the circumstances. Actual results may differ from these estimates under different assumptions or conditions. Our critical accounting policies and estimates
are discussed in our 2009 10-K.

Recent Accounting Pronouncements

There have been no recent accounting pronouncements or changes in accounting pronouncements during the six months ended June 30, 2010, as compared to
the recent accounting pronouncements described in our 2009 10-K, that are of significance, or potential significance to us, except as noted below.

In April 2010, the Financial Accounting Standards Board issued ASU 2010-17, Revenue Recognition - Milestone Method (Topic 605).The ASU provides
guidance on defining a milestone and determining when it may be appropriate to apply the milestone method of revenue recognition for research or development transactions. ASU 2010-17 is effective on a prospective basis for milestones achieved in
fiscal years and interim periods within those years, beginning on or after June 15, 2010. We are currently evaluating the potential impact of ASU 2010-17 on our financial position and results of operations.

In February 2010, the FASB issued ASU 2010-09, Subsequent Events (Topic 855): Amendments to Certain Recognition and Disclosure
Requirements. The amendments in the ASU remove the requirement for an SEC filer to disclose a date through which subsequent events have been evaluated in both issued and revised financial statements. The amendment is effective for interim
or annual periods ending after June 15, 2010. We do not expect the adoption of ASU 2010-09 to have a material effect on our financial condition or results of operations.

In January 2010, the Financial Accounting Standards Board issued ASU 2010-06, Fair Value Measurements and Disclosures (Topic 820) 
Improving Disclosures about Fair Value Measurements. ASU No. 2010-06 requires an entity to disclose separately the amounts of significant transfers in and out of Level 1 and 2 fair value measurements, and describe the reasons for the
transfers. Also, it requires additional disclosure regarding purchases, sales, issuances and settlements of Level 3 measurements. ASU 2010-06 is effective for interim and annual periods beginning after December 15, 2009, except for the
additional disclosure of Level 3 measurements, which is effective for fiscal years beginning after December 15, 2010. The adoption of ASU 2010-06 did not have a material impact on our financial position and results of operations.

(2) CASH EQUIVALENTS

Our
available-for-sale securities as of June 30, 2010 and December 31, 2009 consisted of money market funds primarily containing U.S. government-backed or collateralized overnight securities with original maturities of ninety days or less. The
carrying value of our money market funds is included in cash equivalents and approximates their fair value.



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A.P. Pharma, Inc.

Notes to Condensed Financial Statements(Continued)

June 30, 2010 and 2009 (unaudited)



Fair Value Measurements

The three tier fair value hierarchy utilized prioritizes the inputs used in measuring fair value as follows: (Level 1) observable inputs such as quoted
prices in active markets; (Level 2) inputs other than the quoted prices in active markets that are observable either directly or indirectly; and (Level 3) unobservable inputs in which there is little or no market data, which require us to develop
our own assumptions. The hierarchy requires us to use observable market data, when available, and to minimize the use of unobservable inputs when determining fair value. On a recurring basis, we measure our available-for-sale securities at fair
value. We used quoted prices in active markets (Level l) to measure our cash equivalents at fair value on a recurring basis in our balance sheets at June 30, 2010 and December 31, 2009. Cash equivalents consist of highly rated money
market funds with maturities of ninety days or less, and are purchased daily at par value with specified yield rates. Due to the high ratings and short-term nature of these funds, we consider all cash equivalents as Level 1 inputs.

(3) NET LOSS PER SHARE INFORMATION

Basic and diluted net loss per share is computed by dividing net loss by the weighted average number of common shares outstanding. Diluted net loss
per share excludes the effect of potentially dilutive securities because they are anti-dilutive. The following table shows the potentially dilutive options, unvested restricted stock awards and warrants outstanding (in thousands):



|                                             |  |                           |  |      
|-------------------------------------------- |  | ------------------------- |  | -----
|                                             |  | Six Months 
EndedJune 30,
|                                             |  | 2010                      |  | 2009 
|Options outstanding                          |  | 3,185                     |  | 3,249
|Unvested restricted stock awards outstanding |  | 606                       |  | 140  
|Warrants outstanding                         |  | 3,977                     |  |     

(4) STOCK-BASED
COMPENSATION

The following table shows the stock-based compensation expense for all awards (in thousands except per share amounts):



|                                                      |  |                             |      |                          |   |      |  |      |       |  |   |     
|----------------------------------------------------- |  | --------------------------- | ---- | ------------------------ | - | ---- |  | ---- | ----- |  | - | ----
|                                                      |  | Three Months EndedJune 
30, |      | Six Months
EndedJune 30,
|                                                      |  | 2010                        |      | 2009                     |   | 2010 |  | 2009
|Operating expenses:                                   |  |                             |      |                          |   |      |  |      |       |  |   |     
|Research and development                              |  | $                           | 81   |                          | $ | 66   |  | $    | 138   |  | $ | 129 
|General and administrative                            |  |                             | 855  |                          |   | 338  |  |      | 1,050 |  |   | 491 
|                                                      |  |                             |      |                          |   |      |  |      |       |  |   |     
|Total stock-based compensation expense                |  | $                           | 936  |                          | $ | 404  |  | $    | 1,188 |  | $ | 620 
|                                                      |  |                             |      |                          |   |      |  |      |       |  |   |     
|Impact on basic and diluted net loss per common share |  | $                           | 0.02 |                          | $ | 0.01 |  | $    | 0.03  |  | $ | 0.02
|                                                      |  |                             |      |                          |   |      |  |      |       |  |   |     

In the three months ended June 30, 2010, we recorded additional
stock-based compensation expense as a result of accelerated vesting of stock options in connection with the resignation of our former chief executive officer.



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A.P. Pharma, Inc.

Notes to Condensed Financial Statements(Continued)

June 30, 2010 and 2009 (unaudited)



The following table summarizes option activity for the six months ended June 30, 2010:



|                               |  |           |   |  |                              |      |                                                |     
|------------------------------ |  | --------- | - |  | ---------------------------- | ---- | ---------------------------------------------- | ----
|                               |  | Shares    |   |  | WeightedAverageExercisePrice |      | WeightedAverageRemainingContractualTerm(Years)
|Outstanding at January 1, 2010 |  | 3,092,417 |   |  | $                            | 1.91 |                                                | 7.90
|Granted                        |  | 787,700   |   |  | $                            | 1.77 |                                                |     
|Exercised                      |  | (30,873   | ) |  | $                            | 1.36 |                                                |     
|Expired and Forfeited          |  | (663,974  | ) |  | $                            | 2.83 |                                                |     
|                               |  |           |   |  |                              |      |                                                |     
|Outstanding at June 30, 2010   |  | 3,185,270 |   |  | $                            | 1.69 |                                                | 5.55
|                               |  |           |   |  |                              |      |                                                |     

The following table summarizes restricted stock award activity for the six months ended June 30, 2010:



|                               |  |          |   |  |                                    |      |  | 
|------------------------------ |  | -------- | - |  | ---------------------------------- | ---- |  | 
|                               |  | Shares   |   |  | WeightedAverageGrantDate FairValue |      | 
|Outstanding at January 1, 2010 |  | 140,000  |   |  | $                                  | 1.00 | 
|Awarded                        |  | 662,602  |   |  | $                                  | 0.89 | 
|Released                       |  | (196,168 | ) |  | $                                  | 1.27 | 
|                               |  |          |   |  |                                    |      | 
|Outstanding at June 30, 2010   |  | 606,434  |   |  | $                                  | 0.79 | 
|                               |  |          |   |  |                                    |      | 

Employee Stock Purchase Plan. We adopted an Employee Stock Purchase Plan (the Purchase
Plan) in 1997. Qualified employees may elect to have a certain percentage of their salary withheld to purchase shares of our common stock under the Purchase Plan. The purchase price per share is equal to 85% of the fair market value of the
stock on specified dates. Sales under the Purchase Plan in the six month ended June 30, 2010 and 2009 were 25,567 and 57,336 shares at an average price of $0.68 and $0.42, respectively. Shares available for future purchase under the Purchase
Plan are 132,512 at June 30, 2010.

(5) COMPREHENSIVE LOSS

Comprehensive loss for the three and six months ended June 30, 2010 and 2009 consists of the following (in thousands):



|                                                             |  |                            |        |   |                          |   |        |      |  |   |        |   |  |   |        |  
|------------------------------------------------------------ |  | -------------------------- | ------ | - | ------------------------ | - | ------ | ---- |  | - | ------ | - |  | - | ------ | -
|                                                             |  | Three Months EndedJune 30, |        |   | Six Months
EndedJune 30, |  
|                                                             |  | 2010                       |        |   | 2009                     |   |        | 2010 |  |   | 2009   |  
|Net loss                                                     |  | $                          | (3,583 | ) |                          | $ | (3,941 | )    |  | $ | (4,078 | ) |  | $ | (6,901 | )
|Unrealized gains on available-for-sale marketable securities |  |                            |       |   |                          |   | 16     |      |  |   |       |   |  |   | 37     |  
|                                                             |  |                            |        |   |                          |   |        |      |  |   |        |   |  |   |        |  
|Comprehensive loss                                           |  | $                          | (3,583 | ) |                          | $ | (3,925 | )    |  | $ | (4,078 | ) |  | $ | (6,864 | )
|                                                             |  |                            |        |   |                          |   |        |      |  |   |        |   |  |   |        |  



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##### Table of Contents

A.P. Pharma, Inc.

Notes to Condensed Financial Statements(Continued)

June 30, 2010 and 2009 (unaudited)



(6) INCOME TAXES

There was no provision for income taxes for three and six months ended June 30, 2010 or 2009 because we incurred net operating losses.

(7) STOCKHOLDERS EQUITY

Private Placement

In October 2009, in a private placement, we sold 7,954,543 shares of our common stock at $0.88 per share and warrants to purchase 3,977,270 shares of our
common stock, exercisable through January 7, 2015, at $0.88 per share (Private Placement). The purchasers paid an additional $0.125 per underlying share for the warrants. Additionally the purchasers had the right to purchase up to an additional
5,165,286 shares at $0.97 per share prior to May 14, 2010 and paid $0.125 per underlying share for the right to purchase such additional shares. Total proceeds were approximately $7.9 million, after deducting expenses associated with the
issuance. We were required to prepare and file Form S-3 registration statements, as permissible under SEC rules and regulations, beginning within 30 days of October 22, 2009, with the SEC for the purpose of registering the securities sold in
this Private Placement for resale. We filed a Form S-3 covering 7,532,617 shares on November 6, 2009, which was declared effective by the SEC on November 17, 2009. However, if we fail to keep any registration statements continuously
effective, we may be obligated to pay to the holders of the shares and warrants liquidated damages in the amount of 1% per month of the purchase price for the shares and warrants, up to a maximum cap of 8% of such purchase price. In addition,
in connection with the closing of the Private Placement, Baker Brothers Investments was granted the right to designate a representative to our board of directors. In February 2010, Stephen R. Davis was appointed to our board of directors as the
Baker Brothers Investments designee.

On May 14, 2010, the right of the investors to purchase up to an additional 5,165,286 shares of our
common stock at $0.97 per share under the Private Placement expired unexercised. Additionally, the right granted to Baker Brothers Investments to designate an additional representative to our board of directors should they exercise their right to
purchase designated additional shares of our common stock under the terms of the securities purchase agreement relating to the Private Placement also expired on May 14, 2010. On June 30, 2010, we filed a Form S-3 covering the remaining
421,926 shares of our common stock related to the October 2009 Private Placement and the 3,977,270 shares of our common stock underlying the warrants, which was declared effective by the SEC on July 8, 2010.

Shareholders Rights Plan

In connection with the Private Placement in October 2009, we amended our Preferred Shareholders Rights Agreement to permit Tang Capital Partners and Baker
Brothers Investments, both purchasers in the Private Placement, to each beneficially own up to 34% and 30%, respectively, of our outstanding common stock. Once exercisable, each right entitles the holder to purchase, at a price of $44.00, one
one-thousandth of a share of Series A Participating Preferred Stock. For a limited period of time following the announcement of any such acquisition or offer, the rights are redeemable by us at a price of $0.01 per right.

If the rights are not redeemed or exchanged, each right will then entitle the holder to receive, upon exercise of such right, a number of shares of our
common stock having a then current value equal to two times the purchase price of such right. Similarly, if the rights are not redeemed or exchanged, and following the acquisition of 20% (34% for Tang Capital Partners, LP and 30% for Baker Brothers
Investments) or more of the outstanding shares of our common stock by a person or group of affiliated or associated persons: (i) we consolidate with or merge into another entity; (ii) another entity consolidates with or merges into us; or
(iii) we sell or otherwise transfer 50% or more of our consolidated assets or earning power, each right will then entitle the holder to receive, upon exercise of such right, a number of shares of common stock of the acquiring company having a
then current value equal to two times the purchase price. For a limited period of time after the exercisability of the rights, each right, at the discretion of the board of directors, may be exercised for such number of shares of common stock
determined in accordance with the rights agreement. We have initially reserved 200,000 shares of preferred stock pursuant to the exercise of these rights. These rights expire on December 31, 2016.



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##### Table of Contents

A.P. Pharma, Inc.

Notes to Condensed Financial Statements(Continued)

June 30, 2010 and 2009 (unaudited)



2007 Equity Incentive Plan

At our annual meeting in May 2010, our stockholders approved an amendment to our 2007 Equity Incentive Plan to increase the maximum number of shares of
common stock available for grant by 2,000,000 shares of common stock, resulting in an aggregate of 5,000,000 shares of common stock authorized for issuance pursuant to awards granted under our 2007 Equity Incentive Plan.

(8) DISCONTINUED OPERATIONS

Cosmeceutical and Toiletry Business

On July 25, 2000, we completed the sale of certain technology rights for our cosmeceutical and toiletry business to RP Scherer Corporation (RP
Scherer), a subsidiary of Cardinal Health, Inc. Under the terms of the agreement with RP Scherer, we guaranteed a minimum gross profit percentage on RP Scherers combined sales of products to Ortho Neutrogena (Ortho) and Dermik (Gross Profit
Guaranty). The guaranty period initially commenced on July 1, 2000 and was to end on the earlier of July 1, 2010 or the end of two consecutive guaranty periods where the combined gross profit on sales to Ortho and Dermik equals or exceeds
the guaranteed gross profit (the two period test). The Gross Profit Guaranty expense totaled $944,000 for the first seven guaranty years and in those years profits did not meet the two period test. Effective March 2007, in conjunction
with a sale of assets by RP Scherers successor company to an Amcol International subsidiary (Amcol), a new agreement was signed between us and Amcol to provide continuity of product supply to Ortho and Dermik. This new agreement potentially
extends the Gross Profit Guaranty period an additional three years to July 1, 2013, unless it is terminated earlier with the two period test. Amcol has indicated that its costs differ from those it charged historically to the RP Scherer
successor company to produce the products. We have requested documentation of the actual costs, but have accrued at the amount Amcol represents it is currently owed. As there is no minimum amount of Gross Profit Guaranty due, no accrual for the
guaranty is estimable for future years. A liability of $565,000 related to the current amount due under gross profit guarantees is recorded in accrued disposition costs as of June 30, 2010.

The cosmeceutical and toiletry business is reported as discontinued operations for all periods presented in the accompanying Consolidated Statements of
Operations.

Loss from discontinued operations represents primarily the loss attributable to changes in estimates of our cosmeceutical and
toiletry business that was sold to RP Scherer on July 25, 2000, as follows (in thousands):



|                                                |  |                             |     |                           |   |      |  |   |      |   |  |   |  
|----------------------------------------------- |  | --------------------------- | --- | ------------------------- | - | ---- |  | - | ---- | - |  | - | -
|                                                |  | Three Months EndedJune 
30, |     | Six Months EndedJune 
30,
|                                                |  | 2010                        |     | 2009                      |   | 2010 |  |   | 2009
|Cosmeceutical and Toiletry Business             |  |                             |     |                           |   |      |  |   |      |   |  |   |  
|Change in estimates for gross profit guarantees |  | $                           | 112 |                           | $ |     |  | $ | (12  | ) |  | $ | 
|                                                |  |                             |     |                           |   |      |  |   |      |   |  |   |  

There was no material basic and diluted loss per common share from
discontinued operations for the three and six months ended June 30, 2010 and 2009.



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##### Table of Contents

A.P. Pharma, Inc.

Notes to Condensed Financial Statements(Continued)

June 30, 2010 and 2009 (unaudited)



(9) SIGNIFICANT AGREEMENTS

Merial

In
September 2009, we entered into a world-wide license and development agreement with Merial Limited, a world leading animal health company, for a long-acting pain management product for cats and dogs. The license and development agreement follows a
successful proof-of concept agreement. Under the terms of the new agreement, we received an upfront license fee and will receive development funding and potential future milestones that are in addition to royalties following commercialization.

Under the license and development agreement, we are obligated to perform reimbursable development services and provide any improvements
related to the licensed technology during the six-year development period. We are recognizing the upfront license fee ratably over the development period, and will recognize revenue from the development services when the services are rendered. Any
milestone payments will be recognized when receipt of the payments is probable.

We recognized $477,000 and $696,000 of revenue related to
development services to Merial in the three and six months ended June 30, 2010, respectively.

Paul Royalty Fund

On January 18, 2006, we sold our rights to royalties on sales of Retin-A
Micro® and
Carac®, effective October 1, 2005, to an affiliate of the Paul Royalty Fund for up to $30 million. Proceeds
of $25 million were received upon the closing of the transaction and used primarily to fund the Phase 3 pivotal trial of APF530, our drug candidate for the prevention of both acute and delayed CINV. The remaining $5 million was to be received upon
the achievement of certain milestones over the successive four years. Upon attainment of one milestone in 2007, an additional $2.5 million was received. The final $2.5 million was received in January 2010. No additional payments are due to us.



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##### Table of Contents

|Item 2. | Managements Discussion and Analysis of Financial Condition and Results of Operations
|------- | -------------------------------------------------------------------------------------

Forward-looking Statements

This Form 10-Q contains forward-looking statements as defined by the Private Securities Reform Act of 1995. These forward-looking statements
involve risks and uncertainties including uncertainties associated with: the progress of our research, development and clinical programs, the possibility that the FDA will require us to take additional steps before resubmitting our NDA for APF530,
which will require substantial time and expense on our part, and the timing of regulatory approval and commercial introduction of APF 530 and future product candidates; our ability to market, commercialize and achieve market acceptance for APF530 or
other future product candidates; our ability to establish collaborations for our technology, APF530 and other future product candidates; our estimates for future performance; our estimates regarding our capital requirements and our needs for
additional financing; and other risks and uncertainties identified in our filings with the Securities and Exchange Commission. We caution investors that forward-looking statements reflect our analysis only on their stated date. We do not
intend to update them except as required by law.

Overview

We are a specialty pharmaceutical company focused on developing products using our proprietary Biochronomer polymer-based drug delivery technology. The
Biochronomer technology consists of bioerodible polymers designed to release drugs over a defined period of time. Our primary focus is on our lead product candidate, APF530, which is being developed for the prevention of chemotherapy-induced nausea
and vomiting (CINV). APF530 contains the 5-HT3 antagonist, granisetron, formulated in our proprietary Biochronomer drug delivery system, which allows therapeutic drug levels to be maintained for five days with a single subcutaneous injection. In May
2009, we filed a New Drug Application (NDA) with the U.S. Federal Drug Administration (FDA) seeking approval for APF530. During 2008, APF530 completed a pivotal Phase 3 clinical trial which was the basis for the application. In March 2010, we
received a Complete Response Letter on the APF530 NDA and intend to respond to the issues in the Complete Response Letter in as timely and expeditious a manner as possible. Until we meet with the FDA and clarify the actions we need to take prior to
resubmitting the NDA for APF530, we will not know what additional expenses and how much time may be required for approval of APF530. If we obtain regulatory approval for APF530, we intend to seek a collaborative arrangement to commercialize APF530,
or anticipate obtaining additional funding and resources that would be required to launch APF530 without a partner.

In addition to APF530, we
have a pipeline of other product candidates that use our Biochronomer technology. One product candidate, an undisclosed opiate for a long-acting pain management product, has been licensed on a world-wide basis to Merial for use with companion
animals. Further development of our pipeline products has been temporarily deferred in order to focus managerial, technical and financial resources on a resubmission responsive to issues identified in the March 2010 Complete Response Letter.

Critical Accounting Policies and Estimates

We prepare our consolidated financial statements in accordance with U.S. generally accepted accounting principles, which requires management to make
estimates and assumptions. Management bases these estimates and assumptions on historical results and known trends as well as management forecasts. Actual results could differ from these estimates and assumptions. See our Annual Report on Form 10-K
for the year ended December 31, 2009 in Part II, Item 7  Managements Discussion and Analysis of Financial Condition and Results of Operations-Critical Accounting Policies and Estimates.



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##### Table of Contents

Recent Accounting Pronouncements

Recent accounting pronouncements are disclosed in Note 1 to the Financial Statements included in Item 1 of this Quarterly Report on Form 10-Q.

Results of Operations for the Three and Six months Ended June 30, 2010 and 2009

Contract revenue, which is derived from work performed under collaborative research and development arrangements, was $530,000 and $14,000 for the three
months ended June 30, 2010 and 2009, respectively and $771,000 and $22,000 for the six months ended June 30, 2010 and 2009, respectively. The majority of our contract revenue for the three and six months ended June 30, 2010 was
derived from an agreement with Merial we entered into in September 2009 for a long-acting pain management product for companion animals.

The
amount of contract revenue varies from period to period depending on the level of activity requested of us by our collaborators. Therefore, we cannot predict the amount of contract revenue in future periods.

Our research and development costs consist primarily of employee salaries and other personnel-related expenses, facility-related expenses, laboratory
consumables, polymer development manufacturing, clinical and pre-clinical related services performed by clinical research organizations, research institutions and other outside service providers.

Research and development expenses under collaborative agreements approximate the revenue recognized, excluding milestone and up-front payments received
under such arrangements.

Research and development expense for the three months ended June 30, 2010 decreased by $1.0 million from $2.9
million for the three months ended June 30, 2009 to $1.9 million. Research and development expense for the six months ended June 30, 2010 decreased by $0.8 million from $5.0 million for the six months ended June 30, 2009 to $4.2
million. The decreases in research and development expenses for the three and six months ended June 30, 2010 as compared with comparable periods in 2009 are primarily due to decreased development, manufacturing and project-related expenses
related to our NDA submission to the FDA, partially offset by the suspension of other research and development projects to conserve resources, as well as headcount reductions in May 2009. Research and development expense is expected to be slightly
lower in 2010, as compared to 2009, as a result of expenditures associated with our response to the FDAs Complete Response Letter in order to obtain FDA approval, as well as pre-commercialization activities for APF530.

Our general and administrative costs consist of salaries and related expenses, professional fees, directors fees, investor relations costs,
insurance expense and related overhead cost allocation.

General and administrative expense for the three months ended June 30, 2010
increased by $1.2 million from $1.1 million for the three months ended June 30, 2009 to $2.3 million. General and administrative expense for the six months ended June 30, 2010 increased by $1.1 million from $2.0 million for the six months
ended June 30, 2009 to $3.1 million. The net increases in both periods were primarily a result of compensation expense incurred in the three months ended June 30, 2010 related to the resignation of our chief executive officer, which was
partially offset by cost containment measures associated with our headcount reductions in May 2009. General and administrative expense is expected to be higher in 2010, as compared to 2009, primarily due to the compensation expense related to the
resignation of our former chief executive officer.

In January 2010, we received a $2.5 million milestone payment from an
affiliate of the Paul Royalty Fund. The payment represents a milestone payment that became due to us in January 2010 under an agreement that we entered into effective October 1, 2005 to sell our royalty rights to Retin-A
Micro® and
Carac®. No additional payments are due to us under this agreement.

Income (loss) from discontinued operations for the three and six months ended June 30, 2010 was $112,000 and $(12,000), respectively, which
represents the income (loss) attributable to the Gross Profit Guaranty associated with the sale of our cosmeceutical and toiletry business. There was no Gross Profit Guaranty gain or loss for the three and six months ended June 30, 2009. See
Note 8 of Notes to Condensed Financial Statements.



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##### Table of Contents

Capital Resources and Liquidity

We had cash and cash equivalents of $5.7 million at June 30, 2010. Cash and cash equivalents decreased by $1.9 million at June 30, 2010 from
December 31, 2009 due primarily to our net loss for the six months ended June 30, 2010, offset by the receipt of the $2.5 million milestone from an affiliate of the Paul Royalty Fund.

In October 2009, we sold 7,954,543 shares of our common stock in a private placement at $0.88 per share and warrants to purchase 3,977,270 shares of our
common stock, exercisable through January 7, 2015, at $0.88 per share (the Private Placement). The purchasers paid an additional $0.125 per underlying share for the warrants. Additionally the purchasers had a right to purchase up to an
additional 5,165,286 shares at $0.97 per share prior to May 14, 2010 and paid $0.125 per underlying share for the right to purchase such additional shares. No purchasers exercised their right to purchase up to an additional 5,165,286 shares of
our common stock at $0.97 per share under the Private Placement and the right expired unexercised on May 14, 2010. Total proceeds were approximately $7.9 million, after deducting expenses associated with the issuance. We were required to
prepare and file Form S-3 registration statements, as permissible under SEC rules and regulations, with the SEC for the purpose of registering for resale the securities sold in this transaction. On November 6, 2009, we filed a Form S-3 covering
7,532,617 shares of our common stock sold in a private placement, which was declared effective by the SEC on November 17, 2009. On June 30, 2010, we filed a Form S-3 covering the remaining 421,926 shares of our common stock related to the
Private Placement and the 3,977,270 shares of our common stock underlying the warrants, which was declared effective by the SEC on July 8, 2010.

Net cash used in continuing operating activities for the six months ended June 30, 2010 was $1.9 million, compared to net cash used of $6.8 million
for the six months ended June 30, 2009. The $4.9 million decrease in net cash used by continuing operating activities from 2009 to 2010 was primarily due to the $2.8 million decrease in net loss for the six months ended June 30, 2010,
as compared to the same period in 2009, and a $1.8 million net change in accrued compensation and accrued expenses. Accrued compensation increased by $0.8 million in the six months ended June 30, 2010 primarily due to the resignation of our
former chief executive officer and accrued expenses decreased by $1.0 million in the six months ended June 30, 2009 primarily due to the completion of clinical trials.

Net cash used in investing activities for the six months ended June 30, 2010 was $12,000 compared to net cash of $412,000 provided by investing
activities for the six months ended June 30, 2009. The change in 2010 from 2009 in cash flows associated with investing activities was primarily due to the purchase of equipment in the six months ended June 30, 2010 and maturities of
marketable securities in the six months ended June 30, 2009.

Net cash provided by financing activities for the six months ended
June 30, 2010 was $60,000 compared to net cash provided of $24,000 for the six months ended June 30, 2009. The increase is due primarily to higher proceeds from stock options exercises.

Historically, we have financed our operations, including technology and product research and development, primarily through sales of our common stock,
royalties received, the sale of our rights to royalties, income from collaborative research and development fees, proceeds received from the sales of our Analytical Standards division and our cosmeceutical and toiletry business and interest earned
on short-term investments.



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##### Table of Contents

In March 2010, we received a Complete Response Letter for our APF530 NDA. In the letter, the FDA raised
questions which preclude the approval of the APF530 NDA in its current form. The full extent of activities, costs and time required to address the FDAs questions is not currently known, however, we expect to clarify the actions required for
resubmission and approval of our NDA at an End of Review meeting. Until we meet with the FDA and clarify the actions we need to take prior to resubmitting the NDA for APF530, we will not know how much additional cash may be required for approval of
APF530. The amount of additional funding that we may require depends on various factors, including the results of the on-going regulatory review by the FDA of our APF530 NDA, our efforts to respond to the FDAs Complete Response Letter, our
ability to establish a partnership with a pharmaceutical company for the commercialization of APF530, the time and costs related to manufacturing of APF530, if approved, and technological and market developments from drugs that may compete with
APF530.

Presently, we do not have sufficient cash resources to meet our cash requirements beyond the fourth quarter of 2010. We will require
additional funding to support our continued operations. Our capital requirements going forward will depend on numerous factors including: the number and characteristics of product development programs we pursue and the pace of each program; the
scope, rate of progress, results and costs of preclinical testing and clinical trials; the time, cost and outcome involved in seeking regulatory approvals; scientific progress in our research and development programs; the magnitude and scope of our
research and development programs; our ability to establish and maintain strategic collaborations or partnerships for research, development, clinical testing; manufacturing and marketing of our product candidates; the cost and timing of establishing
sales, marketing and distribution capabilities for a specialty sales force if we commercialize any products independently; the cost of establishing clinical and commercial supplies of our product candidates and any products that we may develop; and
general market conditions.

We will be seeking additional financing to continue our activities, which may include a collaborative arrangement,
an equity offering, debt financing, or some combination of these funding sources. If we are unable to complete such a financing or are unable to obtain sufficient financing on acceptable terms or otherwise, due to various factors including our
ability to continue trading on the Nasdaq Capital Market, we may be required to further reduce, defer, or discontinue our activities or may not be able to continue as a going concern.

We may not be able to raise sufficient additional capital when we need it or to raise capital on favorable terms. The sale of additional equity or
convertible debt securities in the future may be dilutive to our stockholders, and debt financing arrangements may require us to pledge certain assets and enter into covenants that could restrict certain business activities or our ability to incur
further indebtedness and may contain other terms that are not favorable to us or our stockholders. If we are unable to obtain adequate funds on reasonable terms, we may be required to curtail operations significantly or to obtain funds by entering
into financing, supply or collaboration agreements on unattractive terms. We do not currently have the financial resources to launch APF530. If APF530 is approved, we anticipate pursuing either a collaborative arrangement with a partner who will
provide the necessary financial resources and expertise to launch APF530 or anticipate obtaining additional funding and resources that would be required to launch APF530 without a partner. There can be no assurance that APF530 will be approved and,
if approved, that we will be successful in obtaining the additional necessary financial resources and expertise, with or without a partner, that will be required to launch APF530.

Below is a summary of fixed payments related to certain contractual obligations (in thousands). This table excludes amounts already recorded on our
condensed balance sheet as current liabilities as of June 30, 2010.



|                       |  |       |     |                 |   |              |  |             |    |                  |   |   |  |   |  
|---------------------- |  | ----- | --- | --------------- | - | ------------ |  | ----------- | -- | ---------------- | - | - |  | - | -
|                       |  | Total |     | Less than1
year |   | 2 to 
3years |  | 4 to 5Years |    | More than5
years
|Other operating leases |  | $     | 436 |                 | $ | 402          |  | $           | 34 |                  | $ |  |  | $ | 
|                       |  |       |     |                 |   |              |  |             |    |                  |   |   |  |   |  

Off- Balance Sheet Arrangements

As of June 30, 2010 we did not have any off-balance sheet arrangements.



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##### Table of Contents

|Item 3. | Quantitative and Qualitative Disclosure about Market Risk
|------- | ---------------------------------------------------------

Our exposure to market rate risk for changes in interest rates relates primarily to our investment portfolio. We do not use derivative financial
instruments. We manage our interest rate risk by maintaining an investment portfolio primarily consisting of debt instruments of high credit quality and relatively short average maturities. Due to the financial crisis and our anticipated cash flow
requirements, we have 100% of our available cash and cash equivalents in cash and a money market fund containing U.S. Government-backed or collateralized overnight securities.



|Item 4. | Controls and Procedures
|------- | -----------------------

Evaluation of
disclosure controls and procedures: We carried out an evaluation, under the supervision and with the participation of our management, including the Acting Chief Executive Officer and Chief Financial Officer, of the effectiveness of our
disclosure controls and procedures as defined in Rule 13a-15(e) and 15(d)-15(e) of the Securities and Exchange Act of 1934. Based upon that evaluation, the Acting Chief Executive Officer and Chief Financial Officer concluded that as of
June 30, 2010, the end of period covered by this report, our disclosure controls and procedures were effective at the reasonable assurance level.

Changes in internal controls: During the three months ended June 30, 2010, there have been no significant changes in our internal control over
financial reporting that materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

PART II. OTHER INFORMATION



|Item 1. | Legal Proceedings
|------- | -----------------

Not applicable.



|Item 1A. | Risk Factors
|-------- | ------------

There have been no material
changes to the risk factors set forth in the Risk Factors section of our 2009 Annual Report on Form 10-K other than the following:

We may not obtain regulatory approval for APF530 or any of our product candidates. Regulatory approval may also be delayed or cancelled or may
entail limitations on the indicated uses of a proposed product.

The process for obtaining approval of a New Drug Application (NDA) is
time consuming, subject to unanticipated delays and costs, and requires the commitment of substantial resources. The regulatory process, particularly for pharmaceutical product candidates like ours, is uncertain, can take many years and requires the
expenditure of substantial resources. Any product that we develop must receive all relevant regulatory agency approvals or clearances, if any, before it may be marketed in the United States or other countries. In particular, human pharmaceutical
therapeutic products are subject to rigorous preclinical and clinical testing and other requirements by the U.S. Food and Drug Administration (FDA or Agency) and similar health authorities in foreign countries. We may not receive necessary
regulatory approvals or clearances to market APF530 or any other product candidate.

On March 19, 2010, we announced that we had received
a Complete Response Letter from the FDA which stated that the NDA we submitted in May 2009 requesting approval of APF530 could not be approved in its present form. The primary points raised in the FDA Complete Response Letter are as follows:

Dosing System



| |  |  | The FDA expressed concerns relating to our two-syringe administration system, including potential issues with the transfer of material from one syringe
to the other syringe prior to patient administration, certain components used in the dosing system and the potential risk of improper administration of the drug product.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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##### Table of Contents

Chemistry, Manufacturing and Control



| |  |  | The FDA has completed inspections of our facility and several of our contract manufacturing facilities. The Agency identified certain deficiencies
during these inspections, and satisfactory resolution of these deficiencies will be required for approval.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | During the NDA review, the FDA asked that we determine if terminal sterilization with gamma irradiation is a feasible approach to enhance the assurance
of sterility. We have subsequently demonstrated that terminal sterilization is feasible, and the FDA has requested we change to terminal sterilization prior to approval.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | The FDA requested clarification and revision of certain analytical specifications proposed in our NDA.
| | - |  | ------------------------------------------------------------------------------------------------------

Clinical



| |  |  | The FDA did not request additional clinical efficacy studies, although the Agency has asked for the re-presentation and re-analysis of select existing
Phase 3 clinical trial data.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | The FDA requested we perform two studies relating to bioavailability and metabolism. We believe these studies should be of short duration in
normal volunteers.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | The FDA did not accept our request to waive the requirement for a thorough QT study. We believe this study should be of short duration in normal
volunteers. We plan to discuss the design and timing of the study with the FDA.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

We intend to discuss some of the
issues with the FDA at an End of Review meeting prior to resubmitting the APF530 NDA. A date for this meeting has not been set.

Our NDA for
APF530 may not be approved after our resubmission, or approval may be delayed, as a result of changes in FDA policies for drug approval prior to the resubmission of our NDA. For example, although many products have been approved by the FDA in recent
years under Section 505(b)(2) under the Federal Food, Drug and Cosmetic Act, objections have been raised to the FDAs interpretation of Section 505(b)(2). If challenges to the FDAs interpretation of Section 505(b)(2) are
successful, the agency may be required to change its interpretation, which could delay or prevent the approval of our NDA for APF530. The review of our resubmitted NDA may also be delayed due to the FDAs internal resource constraints.

Additionally, data obtained from preclinical and clinical activities is susceptible to varying interpretations that could delay, limit or
prevent regulatory agency approvals or clearances. For example, the FDA may require additional clinical data to support approval, such as confirmatory studies and other data or studies to address questions or concerns that may arise during the FDA
review process.

Delays in resubmitting an NDA and obtaining regulatory agency approval for APF530, or a second Complete Response letter,
would, among other consequences:



| |  |  | significantly harm the marketing of APF530 or any product that we develop;
| | - |  | --------------------------------------------------------------------------



| |  |  | impose costly procedures upon our activities;
| | - |  | ---------------------------------------------



| |  |  | diminish any competitive advantages that we may attain; or
| | - |  | ----------------------------------------------------------



| |  |  | adversely affect our ability to receive royalties and generate revenue and profits.
| | - |  | -----------------------------------------------------------------------------------

All of these consequences would increase our need for additional capital resources.



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Even if granted, regulatory approvals may include significant limitations on the uses for which products may
be marketed. Failure to comply with applicable regulatory requirements can, among other things, result in warning letters, imposition of civil penalties or other monetary payments, delay in approving or refusal to approve a product candidate,
suspension or withdrawal of regulatory approval, product recall or seizure, operating restrictions, interruption of clinical trials or manufacturing, injunctions and criminal prosecution.

In addition, the marketing and manufacturing of drugs and biological products are subject to continuing FDA review, and later discovery of previously
unknown problems with a product, its manufacture or its marketing may result in the FDA requiring further clinical research or restrictions on the product or the manufacturer, including withdrawal of the product from the market.

Additional capital will be needed to enable us to implement our business plan, and we may be unable to raise capital when needed, which would force
us to limit or cease our operations and related product development programs. Raising such capital may have to be accomplished on unfavorable terms, possibly causing dilution to our existing stockholders.

As disclosed in our Annual Report on Form 10-K for the year ended December 31, 2009 filed with the SEC on March 15, 2010, we believed we had
sufficient cash resources to fund operations through fiscal 2010. On March 19, 2010 we announced the receipt of a Complete Response Letter from the FDA on the APF530 NDA. In the letter, the FDA raised questions which preclude the approval of
the APF530 NDA in its current form. The full extent of activities, costs and time required to address the FDAs questions is not currently known, however, we expect to clarify the actions required for resubmission and approval of our NDA at an
End of Review meeting. Until we meet with the FDA and clarify the actions we need to take prior to resubmitting the NDA for APF530, we will not know how much additional cash may be required to reach approval for APF530.

We currently expect current capital resources to allow us to operate through the fourth quarter of 2010 as we continue to defer certain discretionary
activities. We will require additional capital to fund our drug development and operating activities. If we are unable to complete a collaborative arrangement, equity offering, debt financing or otherwise obtain sufficient financing, we may be
required to further reduce, defer, or discontinue our activities or may not be able to continue as a going concern. In addition, the amount of additional funding that we may require in 2010 and beyond depends on various factors, including the
results of an End of Review Meeting with the FDA for our APF530 NDA, our ability to establish a partnership with a pharmaceutical company for the commercialization of APF530, the time and costs related to manufacturing APF530, if approved, and
technological and market developments that compete with APF530. We do not currently have the financial resources to launch APF530. If APF530 is approved, we anticipate pursuing either a collaborative arrangement with a partner who will provide the
necessary financial resources and expertise to launch APF530 or anticipate obtaining additional funding and resources that would be required to launch APF530 without a partner. There can be no assurance that APF530 will be approved and, if approved,
that we will be successful in obtaining the additional necessary financial resources and expertise, with or without a partner, that will be required to launch APF530.

In addition, the timing and degree of any longer-term capital requirements will depend on many factors, including:



| |  |  | the number and characteristics of product development programs we pursue and the pace of each program;
| | - |  | ------------------------------------------------------------------------------------------------------



| |  |  | the scope, rate of progress, results and costs of preclinical testing and clinical trials;
| | - |  | ------------------------------------------------------------------------------------------



| |  |  | the time, cost and outcome involved in seeking regulatory approvals;
| | - |  | --------------------------------------------------------------------



| |  |  | scientific progress in our research and development programs;
| | - |  | -------------------------------------------------------------



| |  |  | the magnitude and scope of our research and development programs;
| | - |  | -----------------------------------------------------------------



| |  |  | our ability to establish and maintain strategic collaborations or partnerships for research, development, clinical testing, manufacturing and marketing
of our product candidates;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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| |  |  | the cost and timing of establishing sales, marketing and distribution capabilities for a specialty sales force if we commercialize any products
independently;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the cost of establishing clinical and commercial supplies of our product candidates and any products that we may develop; and
| | - |  | -----------------------------------------------------------------------------------------------------------------------------



| |  |  | general market conditions.
| | - |  | --------------------------

We do not anticipate that we will generate significant continuing revenues for at least several years, if ever. Until we can generate significant
continuing revenues, we expect to satisfy our future cash needs through public or private equity offerings, debt financings, as well as strategic collaborations, in the form of license fees, research and development fees and milestone payments. If
we issue additional equity securities or securities convertible into equity securities to raise funds, our stockholders will suffer dilution of their investment and it may adversely affect the market price of our common stock. Any debt financing we
enter into may involve covenants that restrict our operations. These restrictive covenants may include, among other things, limitations on borrowing, specific restrictions on the use of our assets, as well as prohibitions on our ability to create
liens, pay dividends, redeem capital stock or make investments. In the event that additional funds are obtained through arrangements with collaborative partners, these arrangements may require us to relinquish rights to some of our technologies,
product candidates or products on terms that are not favorable to us or require us to enter into a collaboration arrangement that we would otherwise seek to develop and commercialize ourselves. If adequate funds are not available, we may again be
required to delay, reduce the scope of, or eliminate one or more of our product development programs and reduce personnel-related and other costs, which will have a material adverse effect on our business.

If our suppliers and contract manufacturers fail to complete pre-commercialization manufacturing development activities for APF530 on a timely
basis or fail to comply with stringent regulatory requirements, we will face delays in our ability to obtain regulatory approval for, and to commercialize, APF530, and our costs will increase.

We do not manufacture APF530, and do not currently plan to develop any capacity to do so. Instead, we have relied on third-parties to manufacture and
perform important pre-commercialization manufacturing development activities for APF530. As part of the process for obtaining regulatory approval, we must demonstrate that the facilities, equipment and processes used to manufacture APF530 are
capable of consistently producing a product that meets all applicable quality criteria, and that is comparable to the product that was used in our clinical trials. We must also provide the FDA with information regarding the validation of the
manufacturing facilities, equipment and processes of our third-party suppliers and manufacturers, and data supporting the stability of APF530. If our third-party suppliers and manufacturers are not in compliance with current good manufacturing
practice requirements, the approval of our marketing application may be delayed, existing product batches may be compromised, and we may experience delays in the availability of APF530 for commercial distribution.

For example, our Complete Response Letter from the FDA regarding our NDA submission for APF530 stated that the NDA could not be approved in its present
form due to, among other issues, deficiencies observed during an inspection of the facilities used by our third-party suppliers and manufacturers to produce APF530. We anticipate that our third-party suppliers and manufacturers will submit a
response to the FDA to address such issues. If the FDA is not satisfied with these responses and any corrective actions taken by these third parties, or if the FDA determines that it is necessary to re-inspect our third-party suppliers and
manufacturers facilities before agreeing that the inspectional observations have been adequately addressed, we may be required to complete additional manufacturing development activities or provide other information in order to resubmit our
NDA, which could cause substantial delays in obtaining regulatory approval for APF530, increase our costs and have a material adverse effect on our business and financial condition.



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|Item 6. | Exhibits
|------- | --------

Exhibit 31.1 - Certification of
Chief Executive Officer pursuant to Rules 13A-15(f) Promulgated under the Securities Exchange Act of 1934 as amended.

Exhibit 31.2 -
Certification of Chief Financial Officer pursuant to Rules 13A-15(f) Promulgated under the Securities Exchange Act of 1934 as amended.

Exhibit 32 - Certification of Chief Executive Officer and Chief Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906
of the Sarbanes-Oxley Act of 2002.



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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.



|                      |  |  |  |                                       
|--------------------- |  |  |  | --------------------------------------
|                      |  |  |  | A.P. PHARMA, INC.                     
|                      |  | 
|Date: August 16, 2010 |  |  |  | /s/    JOHN B.
WHELAN                 
|                      |  |  |  | John B. Whelan
Chief Financial Officer



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