THE IMMUNE RESPONSE CORPORATION
8% CONVERTIBLE SECURED PROMISSORY NOTE

|$1,000,000 |  | New York, New York
June 24, 2002
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FOR
the receipt of $1,000,000 the undersigned, The Immune Response Corporation, a Delaware corporation (the "Issuer"), hereby unconditionally promises to pay on the Note Maturity Date
(as defined in that certain Note Purchase Agreement, dated November 9, 2001, by and between the Purchaser, Kevin Kimberlin Partners, L.P., a Delaware limited partnership, and the Issuer, and as
amended as of February 14, 2002 and further amended as of May 3, 2002 (the "Note Purchase Agreement")) to the order of Oshkim Limited Partnership, a Delaware limited partnership (the
"Purchaser"), at the office of the Purchaser located at 535 Madison Avenue, 18th Floor, New York, New York 10022, or such other address designated by the Purchaser, in lawful money of
the United States of America and in immediately available funds, the principal amount of (a) One Million Dollars ($1,000,000) or (b) if less as a result of any voluntary conversion(s) of
this Note in part in accordance
with Section 3.4 of the Note Purchase Agreement or in part into Units as contemplated below, the aggregate unpaid principal amount of this Note. Subject to Section 3.4 of the Note
Purchase Agreement, the Issuer further agrees to pay interest on the unpaid principal amount outstanding hereunder from time to time, from the date hereof, in like money, at the rate of eight (8%)
percent per annum, as and at the dates specified in Section 3.3 of the Note Purchase Agreement.

This
Note is one of the promissory notes referred to in the Note Purchase Agreement, and is entitled to the benefits thereof, is secured as provided therein (and as provided in that
certain Intellectual Property Security Agreement, dated November 9, 2001, executed by the Issuer and as amended as of February 14, 2002) and is subject to conversion as set forth
therein. Notwithstanding the foregoing, this Note (including all accrued interest) is convertible, at the sole option of the Purchaser, in whole or in part, into Units (as defined in the Issuer's
Definitive Proxy Statement dated May 15, 2002, the "Proxy") rather than common stock at the Closing Price (as defined in the Proxy), solely in the event that the Issuer is (i) able to
obtain a written confirmation from The Nasdaq Stock Market that there is an applicable exemption to do so from all applicable subsections of the National Association of Security Dealers, Inc.
("NASD") Rule 4350(i) or (ii) able to obtain stockholder approval as required by NASD Rule 4350(i).

In
the event of any conflict between the Note Purchase Agreement and this Note, the terms and provisions of the Note Purchase Agreement shall govern.

Upon
the occurrence of (i) any one or more of the Events of Default specified in the Note Purchase Agreement, or (ii) if Issuer shall default in the payment of principal on
any indebtedness (to any party other that the Purchaser or KKP) in excess of $200,000 beyond the period of grace, if any, provided in the instrument or agreement under which such indebtedness was
created, all amounts then remaining unpaid on this Note shall become, or may be declared to be, immediately due and payable, all as provided in the Note Purchase Agreement.

Subject
to the provisions of the legend above, this Note is freely transferable, in whole or in part, by the Purchaser, and such transferee shall have the same rights hereunder as the
Purchaser. The

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Issuer may not assign or delegate any of its obligations under this Note without the prior written consent of the Purchaser (or its successor, transferee or assignee).

All
parties now and hereafter liable with respect to this Note, whether maker, principal, surety, guarantor, endorser or otherwise, hereby waive presentment, demand, protest and all
other notices of any kind.

Subject
to Section 3.3 of the Note Purchase Agreement, the Issuer agrees to pay all of the Purchaser's expenses, including reasonable attorneys' costs and fees, incurred in
collecting sums due under this Note.

This
Note shall be subject to prepayment only in accordance with the terms of the Note Purchase Agreement.

This
Note shall be governed by, and construed and interpreted in accordance with, the laws of the State of New York.

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| |  | THE IMMUNE RESPONSE CORPORATION
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| |  | By:                            
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