|Exhibit 10.91
|-------------



| | THE SECURITIES REPRESENTED HEREBY HAVE BEEN
      ISSUED WITHOUT REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED,
      OR UNDER ANY STATE SECURITIES LAWS, AND MAY NOT BE SOLD, TRANSFERRED OR
      PLEDGED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT UNDER APPLICABLE
      FEDERAL AND STATE SECURITIES LAWS OR AN OPINION OF COUNSEL REASONABLY SATISFACTORY
      TO THE COMPANY THAT THE TRANSFER IS EXEMPT FROM REGISTRATION UNDER APPLICABLE
      FEDERAL AND STATE SECURITIES LAWS. | 
| | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | 



|THE IMMUNE RESPONSE CORPORATION 8% CONVERTIBLE SECURED PROMISSORY NOTE
|----------------------------------------------------------------------



|$4,000,000 | New York, New York
      May 3, 2002
|---------- | ------------------------------------



|FOR
the receipt of $1,980,712.33 in cash and the cancellation of $2,000,000 of principal
indebtedness plus $19,287.67 interest represented by the 8% Secured Promissory Note dated
March 20, 2002 from the Issuer to the Purchaser (as defined below), the undersigned, The
Immune Response Corporation, a Delaware corporation (the Issuer), hereby
unconditionally promises to pay on the Note Maturity Date (as defined in that certain
Note Purchase Agreement, dated November 9, 2001, by and between the Purchaser, Kevin
Kimberlin Partners, L.P., a Delaware limited partnership, and the Issuer, and as amended
as of February 14, 2002 and further amended as of May 3, 2002 (the Note Purchase
Agreement)) to the order of Oshkim Limited Partnership, a Delaware limited partnership
(the Purchaser), at the office of the Purchaser located at 535 Madison Avenue, 18th
Floor, New York, New York 10022, or such other address designated by the Purchaser, in
lawful money of the United States of America and in immediately available funds, the
principal amount of (a) Four Million Dollars ($4,000,000) or (b) if less as a result of
any voluntary conversion(s) of this Note in part in accordance with Section 3.4 of the
Note Purchase Agreement, the aggregate unpaid principal amount of this Note. Subject to
Section 3.4 of the Note Purchase Agreement, the Issuer further agrees to pay interest on
the unpaid principal amount outstanding hereunder from time to time, from the date
hereof, in like money, at the rate of eight (8%) percent per annum, as and at the dates
specified in Section 3.3 of the Note Purchase Agreement.
|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|This
Note is one of the promissory notes referred to in the Note Purchase Agreement, and is
entitled to the benefits thereof, is secured as provided therein (and as provided in that
certain Intellectual Property Security Agreement, dated November 9, 2001, executed by the
Issuer and as amended as of February 14, 2002) and is subject to conversion as set forth
therein. In the event of any conflict between the Note Purchase Agreement and this Note,
the terms and provisions of the Note Purchase Agreement shall govern.
|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|Upon
the occurrence of any one or more of the Events of Default specified in the Note Purchase
Agreement, all amounts then remaining unpaid on this Note shall become, or may be
declared to be, immediately due and payable, all as provided in the Note Purchase
Agreement.
|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



---





|Subject
to the provisions of the legend above, this Note is freely transferable, in whole or in
part, by the Purchaser, and such transferee shall have the same rights hereunder as the
Purchaser. The Issuer may not assign or delegate any of its obligations under this Note
without the prior written consent of the Purchaser (or its successor, transferee or
assignee).
|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|All
parties now and hereafter liable with respect to this Note, whether maker, principal,
surety, guarantor, endorser or otherwise, hereby waive presentment, demand, protest and
all other notices of any kind.
|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|Subject
to Section 3.3 of the Note Purchase Agreement, the Issuer agrees to pay all of the
Purchasers expenses, including reasonable attorneys costs and fees, incurred in
collecting sums due under this Note.
|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|This
Note shall be subject to prepayment only in accordance with the terms of the Note
Purchase Agreement.
|----------------------------------------------------------------------------------------------------------



|This
Note shall be governed by, and construed and interpreted in accordance with, the laws of
the State of New York.
|--------------------------------------------------------------------------------------------------------------------



| | THE IMMUNE RESPONSE CORPORATION
      By: ______________________________________
| | --------------------------------------------------------------------------------

| | Name:__________________________________
      Title:___________________________________
| | ---------------------------------------------------------------------------------------



| | -2- | 
| | --- | 



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