Exhibit 10.95

AMENDMENT NO. 3 TO NOTE PURCHASE AGREEMENT

This AMENDMENT NO. 3 is made as of the 11th day of July, 2002 (the "Amendment") by and between Kevin Kimberlin Partners, L.P., a Delaware limited partnership
("KKP"), The Immune Response Corporation, a Delaware corporation ("Seller"), Oshkim Limited Partnership ("Oshkim") and The Kimberlin Family 1998 Irrevocable Trust (the "Trust");

WHEREAS,
Seller, KKP and Oshkim entered into that certain Note Purchase Agreement dated as of November 9, 2001, as amended by Amendment No. 1 to Note Purchase Agreement
dated as of February 14, 2002 and as further amended by Amendment No. 2 to Note Purchase Agreement dated as of May 3, 2002 (the "Agreement");

WHEREAS,
the Seller proposes to issue and sell Additional Securities to the Trust and the Trust wishes to purchase Additional Securities from Seller.

WHEREAS,
the parties desire to amend the Agreement to add the Trust and any affiliates of KKP, Oshkim and/or the Trust as parties and in certain other respects as set forth below.

NOW,
THEREFORE, in consideration of the foregoing premises and the mutual covenants set forth below, the parties hereby amend the Agreement and agree as follows:

1.    Effective
as of the date of this Amendment, the Agreement is hereby amended as follows:



2.    Except
as specifically provided herein, the Agreement, as originally executed by the parties thereto and as amended hereby, shall remain in full force and effect.

3.    Any
defined terms not defined herein shall have the respective meanings set forth in the Agreement.

4.    This
Amendment may be executed in counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument.

5.    This
Amendment shall be governed by and construed in accordance with the internal laws of the State of New York applicable to agreements made and to be performed entirely
within such jurisdiction.

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IN
WITNESS WHEREOF, the parties hereto have executed this Amendment as of the date first above written.

| |  | KEVIN KIMBERLIN PARTNERS, L.P.             
| |  | -------------------------------------------
| |  |                                            
| |  | By:                                        
| |  |                                            
| |  |                                            
| |  |                                            
| |  |                                            
| |  |                                            
| |  |                                            
| |  | OSHKIM LIMITED PARTNERSHIP                 
| |  |                                            
| |  | By:                                        
| |  |                                            
| |  |                                            
| |  |                                            
| |  |                                            
| |  |                                            
| |  |                                            
| |  | THE KIMBERLIN FAMILY 1998 IRREVOCABLE TRUST
| |  |                                            
| |  | By:                                        
| |  |                                            
| |  |                                            
| |  |                                            
| |  |                                            
| |  |                                            
| |  |                                            
| |  | THE IMMUNE RESPONSE CORPORATION            
| |  |                                            
| |  | By:                                        
| |  |                                            
| |  |                                            
| |  |                                            
| |  |                                            
| |  |                                            

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