**Exhibit 31.1**

** **

**Certification of Chief Executive Officer**

**Pursuant toSection 302 of the Sarbanes-Oxley Act of 2002**

 

 

I, John N. Bonfiglio, certify that:

 

1.               I have reviewed this quarterly report onForm 10-Q of The Immune Response Corporation;

 

2.               Based on my knowledge, this quarterlyreport does not contain any untrue statement of a material fact or omit tostate a material fact necessary to make the statements made, in light of thecircumstances under which such statements were made, not misleading with respectto the period covered by this report;

 

3.               Based on my knowledge, the financialstatements, and other financial information included in this quarterly report,fairly present in all material respect the financial condition, results ofoperations and cash flows of the registrant as of, and for, the periodspresented in this report;

 

4.               The registrant’s other certifyingofficer and I are responsible for establishing and maintaining disclosurecontrols and procedures (as defined in Exchange Act Rules 13a-15(e) and15d-15(e)) for the registrant and we have:

 

(a)          designed such disclosure controls andprocedures or caused such disclosure controls and procedures to be designedunder our supervision, to ensure that material information relating to theregistrant, including its consolidated subsidiaries, is made known to us byothers within those entities, particularly during the period in which thisreport is being prepared;

 

(b)         evaluated the effectiveness of theregistrant’s disclosure controls and procedures and presented in thisreport  our conclusions about theeffectiveness of the disclosure controls and procedures, as of the end of theperiod covered by this report based on such evaluation; and

 

(c)          disclosed in this report any change in theregistrant’s  internal control overfinancial reporting that occurred during the registrant’s most recent fiscalquarter that has materially affected, or is reasonably likely to materiallyaffect, the registrant’s internal control over financial reporting; and

 

5.               The registrant’s other certifyingofficer and I have disclosed, based on our most recent evaluation of internalcontrol over financial reporting, to the registrant’s auditors and the auditcommittee of registrant’s board of directors (or persons performing the equivalentfunctions):

 

(a)          all significant deficiencies and materialweaknesses in the design or operation of internal control over financialreporting which are reasonably likely to adversely affect the registrant’sability to record, process, summarize and report financial information; and

 

(b)         any fraud, whether or not material, thatinvolves management or other employees who have a significant role in theregistrant’s internal control over financial reporting.

 

 
| Date: November 14, 2003 |   |                        |              |
|-------------------------|--------|-----------------------------|-------------------|
|                    |   | /s/                         | John N. Bonfiglio |   |
|                    |   | John N. Bonfiglio           |              |
|                    |   | Principal Executive Officer |              |
|                         |        |                             |                   |  |

 

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