|Exhibit 10.90
|-------------



|AMENDMENT NO. 2 TO NOTE PURCHASE AGREEMENT
|------------------------------------------



|This
AMENDMENT NO. 2 is made as of the 3rd day of May, 2002 (the Amendment) by and between
Kevin Kimberlin Partners, L.P., a Delaware limited partnership (KKP), The Immune
Response Corporation, a Delaware corporation (Seller), and Oshkim Limited Partnership
(Oshkim).
|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|WHEREAS,
Seller, KKP and Oshkim entered into that certain Note Purchase Agreement dated as of
November 9, 2001, as amended by Amendment No. 1 to Note Purchase Agreement dated as of
February 14, 2002 (the Agreement).
|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|WHEREAS,
Seller proposes to issue and sell Additional Securities to Oshkim and Oshkim wishes to
purchase Additional Securities (as defined in the Agreement) from Seller.
|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|WHEREAS,
the parties desire to amend the Agreement as set forth below.
|----------------------------------------------------------------------



|NOW,
THEREFORE, in consideration of the foregoing premises and the mutual covenants set forth
below, the parties hereby amend the Agreement and agree as follows:
|-----------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 1. | Effective as of the date of this Amendment,
      the Agreement is hereby amended as follows:
| | -- | ---------------------------------------------------------------------------------------------



| | a. | The third recital is hereby amended
      to substitute $4,000,000 for $2,000,000.
| | -- | --------------------------------------------------------------------------------------



| | b | Section 6.2(a) is hereby amended to
      add a new last sentence which shall read in its entirety as follows:
| | - | --------------------------------------------------------------------------------------------------------------



| | Notwithstanding the foregoing,
      Seller and Oshkim acknowledge and accept that as of the date of Amendment
      No. 2 to this Agreement Seller does not have reserved and available out
      of its authorized but unissued shares of Common Stock sufficient shares
      of Common Stock for the purpose of issuing Common Stock upon the exercise
      in full of the Warrants issued to Oshkim on May 3, 2002. Seller shall promptly
      take all corporate action as may be necessary to increase its authorized
      but unissued shares of Common Stock to such number of shares as shall be
      sufficient for reserving and making available shares of Common Stock issuable
      upon the exercise in full of the Warrants issued to Oshkim on May 3, 2002.
| | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|2.
             Except as specifically provided
      herein, the Agreement, as originally executed by the parties thereto and
      as amended hereby, shall remain in full force and effect.
|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|3.
             Any defined terms not defined
      herein shall have the respective meanings set forth in the Agreement.
|-------------------------------------------------------------------------------------------------------------------------



|4.
             This Amendment may be executed
      in counterparts, each of which shall be deemed an original, but all of which
      together shall constitute one and the same instrument.
|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|5.
             This Amendment shall be governed
      by and construed in accordance with the internal laws of the State of New
      York applicable to agreements made and to be performed entirely within such
      jurisdiction.
|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | -1- | 
| | --- | 

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|IN
WITNESS WHEREOF, the parties hereto have executed this Amendment as of the date first
above written.
|-------------------------------------------------------------------------------------------------------



| | KEVIN KIMBERLIN PARTNERS, L.P. 
      By:______________________________________
| | -------------------------------------------------------------------------------

| | Name: _________________________________
      
      Title: __________________________________
| | ----------------------------------------------------------------------------------------------



| | OSHKIM LIMITED PARTNERSHIP 
      By: _____________________________________
| | ---------------------------------------------------------------------------

| | Name:_________________________________
      Title:__________________________________
| | -------------------------------------------------------------------------------------



| | THE IMMUNE RESPONSE CORPORATION 
      By:______________________________________
| | --------------------------------------------------------------------------------

| | Name:__________________________________
      Title:___________________________________
| | ---------------------------------------------------------------------------------------



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