March 13, 2014


 


GenVec, Inc.


65 West Watkins Mill Road


Gaithersburg, MD 20878


 


Ladies and Gentlemen:


 


The undersigned (the “Investor”)
hereby confirms and agrees with you as follows:


 


1.           This
Purchase Agreement (the “Agreement”) is made as of the date hereof between GenVec, Inc., a Delaware corporation (the
“Company”), and the Investor that is a signatory to this Agreement.


 


2.           The
Company has authorized the sale and issuance (the “Offering”) of up to 2,870,000 shares of its common stock (the “Offered
Securities”), par value $0.001 per share (the “Common Stock”).  The Offering is being made pursuant to an
effective shelf registration statement on Form S-3 (SEC File No. 333-193511).


 


3.           The
Company and the Investor agree that the Offering is being made subject to the execution by the Company and the Placement Agents
of the Placement Agency Agreement, delivery of the base prospectus and a preliminary prospectus supplement relating to the Offered
Securities and delivery of additional offering information, including pricing information.  The Company and the Investor
agree that the Investor will purchase from the Company and the Company will issue and sell to the Investor the number of Offered
Securities set forth below the Investor’s name on Schedule I hereto, at a purchase price of $3.15 per share, pursuant to
the Terms and Conditions for Purchase of Offered Securities attached hereto as Annex I and incorporated herein by reference
as if fully set forth herein.  The Investor acknowledges that the Offering is not being underwritten by the Placement
Agents and that there is no minimum offering amount.  Shares of Common Stock will be credited to the Investor using customary
book-entry procedures.


 


4.           The
Investor represents that, except as set forth below, (a) it has had no position, office or other material relationship within the
past three years with the Company or persons known to it to be affiliates of the Company, (b) neither it, nor any group of which
it is a member or to which it is related, beneficially owns (including the right to acquire or vote) more than 19.9% of any class
of securities of the Company and (c) it is not a FINRA member as of the date hereof.


 


5.           The
Investor confirms that it has had full access to all filings made by the Company with the Securities and Exchange Commission, including
the registration statement and base prospectus relating to the Offered Securities, and the documents incorporated by reference
therein, and that it was able to read, review, download and print each such filing.


 




    	 



    	 



    

 


Please confirm that the foregoing correctly
sets forth the agreement between us by signing in the space provided below for that purpose.


 


	 	Name of Investor:	 	 
	 	 	 	 
	 	 	 	By:	 
	 	 	 	 	 
	 	 	 	Name:	 
	 	 	 	 	 
	 	 	 	Title:	 


 


AGREED AND ACCEPTED:


 


GENVEC, INC.


 


	By:	 	 
	 	 	 
	Name:	 	 
	 	 	 
	Title:	 	 


 




    	 



    	 



    

 


SCHEDULE I


 


SCHEDULE OF INVESTORS


	Name of Investor:
	 
	_________________________________
	 
	Name of Individual Representing

Investor:
	 
	_________________________________
	 
	Title of Individual Representing

Investor:
	 
	_________________________________


 


	Address:	 	 
	 	 	 
	Telephone:	 	 
	 	 	 
	Telecopier:	 	 


 


	
        Number of Offered 

        Securities to Be 

        Purchased
	
        Price Per Share In 

        Dollars
	
        Aggregate 

        Purchase Price

	 	$3.15	$


 




    	 



    	 



    

 


ANNEX I


 


TERMS AND CONDITIONS FOR PURCHASE OF
OFFERED SECURITIES


 


1.           Agreement
to Sell and Purchase the Offered Securities; Placement Agents.


 


1.1         Upon
the terms and subject to the conditions hereinafter set forth, at the Closing (as defined in Section 2 below), the Company will
sell to the Investor, and the Investor will purchase from the Company, the number of shares of Common Stock set forth on Schedule
I of this Agreement below such Investor’s name at the purchase price set forth therein.


 


1.2         
The Company may enter into agreements similar to this Agreement with certain other investors (the “Other Investors”)
and expects to complete sales of Offered Securities to them. (The Investor and the Other Investors hereinafter collectively are
referred to as the “Investors,” and this Agreement and the agreements executed by the Other Investors are hereinafter
collectively referred to as the “Agreements”). The Company may accept or reject any one or more Agreements in its sole
discretion.


 


1.3           The
Company has entered into a Placement Agency Agreement (the “Placement Agency Agreement”) dated the date hereof with
Roth Capital Partners, LLC and H.C. Wainwright & Co., LLC in their capacities as Placement Agents for the Offering (together,
the “Placement Agents”), and the Company has agreed to pay the Placement Agents a fee in respect of the sale of the
Common Stock.


 


2.           Delivery
of the Shares at Closing.  The completion of the purchase and sale of the Offered Securities (the “Closing”)
shall take place at a place and time (the “Closing Date”) to be specified by the Company and the Placement Agents,
in accordance with Rule 15c6-1 promulgated under the Securities Exchange Act of 1934, as amended (the “Exchange Act”).


 


  The Company’s obligation to
issue and sell the Offered Securities at Closing to the Investor shall be subject to the accuracy of the representations and warranties
made by the Investor and the fulfillment of those undertakings of the Investor to be fulfilled prior to the Closing.


 


  The Investor’s obligation to
purchase the Offered Securities shall be subject to the condition that the Placement Agents shall not have (a) terminated the Placement
Agency Agreement pursuant to the terms thereof or (b) determined that the conditions to closing in the Placement Agency Agreement
have not been satisfied.


 


The manner of settlement of the Offered Securities
purchased by the Investor shall be determined by such Investor as follows (check one):


 


[          ]
A.     [____]   A.     Delivery by crediting the account of the Investor’s prime broker (as specified by such Investor on
Exhibit A annexed hereto) with the Depository Trust Company (“DTC”) through its Deposit/Withdrawal At Custodian (“DWAC”)
system, whereby Investor’s prime broker shall initiate a DWAC transaction on the Closing Date using its DTC participant identification
number, and released by American Stock Transfer & Trust Company, the Company’s transfer agent (the “Transfer Agent”),
at the Company’s direction. NO LATER THAN ONE (1) BUSINESS DAY AFTER THE EXECUTION OF THIS AGREEMENT BY THE INVESTOR AND
THE COMPANY, THE INVESTOR SHALL:


 


		(I)	DIRECT THE BROKER-DEALER AT WHICH THE ACCOUNT OR ACCOUNTS TO BE CREDITED WITH THE SHARES ARE MAINTAINED TO SET UP A DWAC INSTRUCTING
THE TRANSFER AGENT TO CREDIT SUCH ACCOUNT OR ACCOUNTS WITH THE SHARES, AND



 






    	 



    	 



    

 


		(II)	REMIT BY WIRE TRANSFER THE AMOUNT OF FUNDS EQUAL TO THE AGGREGATE PURCHASE PRICE FOR THE OFFERED SECURITIES BEING PURCHASED
BY THE INVESTOR TO THE FOLLOWING ACCOUNT:



 


[To be separately provided to the Investor]


—OR—


 


[____]    B.    Delivery Versus
Payment (“DVP”) through DTC (i.e., on the Closing Date, the Company shall issue the Offered Securities registered
in the Investor’s name and address as set forth below and released by the Transfer Agent directly to the account(s) at Roth
Capital Partners, LLC (“Roth”) identified by the Investor; upon receipt of such Offered Securities, Roth shall
promptly electronically deliver such Offered Securities to the Investor, and simultaneously therewith payment shall be made by
Roth by wire transfer to the Company). NO LATER THAN ONE (1) BUSINESS DAY AFTER THE EXECUTION OF THIS AGREEMENT BY THE INVESTOR
AND THE COMPANY, THE INVESTOR SHALL:


 


		(III)	NOTIFY ROTH OF THE ACCOUNT OR ACCOUNTS AT ROTH TO BE CREDITED WITH THE SHARES BEING PURCHASED BY SUCH INVESTOR, AND



 


		(IV)	CONFIRM THAT THE ACCOUNT OR ACCOUNTS AT ROTH TO BE CREDITED WITH THE SHARES BEING PURCHASED BY THE INVESTOR HAVE A MINIMUM
BALANCE EQUAL TO THE AGGREGATE PURCHASE PRICE FOR THE UNITS BEING PURCHASED BY THE INVESTOR.



 


IT IS THE INVESTOR’S RESPONSIBILITY
TO (A) MAKE THE NECESSARY WIRE TRANSFER OR CONFIRM THE PROPER ACCOUNT BALANCE IN A TIMELY MANNER AND (B) ARRANGE FOR SETTLEMENT
BY WAY OF DWAC OR DVP IN A TIMELY MANNER. IF THE INVESTOR DOES NOT DELIVER THE AGGREGATE PURCHASE PRICE FOR THE OFFERED SECURITIES
OR DOES NOT MAKE PROPER ARRANGEMENTS FOR SETTLEMENT IN A TIMELY MANNER, THE OFFERED SECURITIES MAY NOT BE DELIVERED AT CLOSING
TO THE INVESTOR OR THE INVESTOR MAY BE EXCLUDED FROM THE CLOSING ALTOGETHER.


 


3.           Representations,
Warranties and Covenants of the Company.  The Company hereby represents and warrants to, and covenants with, the
Investor, as follows:


 


3.1         The
issuance and sale of each of the Offered Securities have been duly authorized by the Company, and the Offered Securities, when
issued and paid for in accordance with this Agreement, will be duly and validly issued, fully paid and nonassessable and will not
be subject to preemptive or similar rights.


 


3.2         This
Agreement constitutes a valid and binding obligation of the Company enforceable against the Company in accordance with its terms,
subject to the effect of applicable bankruptcy, insolvency or similar laws affecting creditors’ rights generally and equitable
principles of general applicability.


 


3.3         The
Company shall not effect any offer or sale of any equity or equity-related securities that would result in the transactions contemplated
hereby becoming subject to stockholder approval under the rules and regulations of FINRA or the NASDAQ Global Market.


 


3.4         It
is understood and acknowledged by the Company that: (i) except pursuant to the terms of this Agreement and any confidentiality
agreement entered into by the Investor with respect to the transactions contemplated hereby, the Investor has not been asked by
the Company to agree, nor has the Investor agreed, to desist from purchasing or selling, long and/or short, securities of the Company,
or “derivative” securities based on securities issued by the Company or to hold the Offered Securities for any specified
term; (ii) past or future open market or other transactions by the Investor, specifically including, without limitation, Short
Sales or “derivative” transactions, before or after the closing of this or future private placement transactions, may
negatively impact the market price of the Company’s publicly-traded securities; (iii) the Investor, and counter-parties in
“derivative” transactions to which the Investor is a party, directly or indirectly, presently may have a “short”
position in the Common Stock, and (iv) the Investor shall not be deemed to have any affiliation with or control over any arm’s
length counter-party in any “derivative” transaction merely by reason of such “derivative” transaction.
The Company further understands and acknowledges that (y) subject to the terms of this Agreement and any confidentiality agreement
entered into by the Investor with respect to the transactions contemplated hereby, the Investor may engage in hedging activities
at various times during the period that the Offered Securities are outstanding, and (z) such hedging activities (if any) could
reduce the value of the existing stockholders’ equity interests in the Company at and after the time that the hedging activities
are being conducted.


 






    	 



    	 



    

 


3.5         The
Company will use its commercially reasonable efforts to maintain the effectiveness of the registration statement through the Closing
in accordance with the rules and regulations promulgated by the Securities and Exchange Commission.


 


3.6         Prior
to 9:30 a.m., New York City time, on March 13, 2014, the Company will issue a press release (the “Press Release”) via
BusinessWire (or other national wire service) announcing the transaction contemplated by this Agreement. In connection with the
transactions contemplated by this Agreement, the Company has not disclosed, or caused to be disclosed, to the Investor any material
non-public information regarding the Company that will not at the time of the issuance of the Press Release be in the public domain.


 


4.           Representations,
Warranties and Covenants of the Investor.  The Investor represents and warrants to the Company as follows:


 


4.1         The
Investor has received the Company’s base prospectus and a preliminary prospectus supplement relating to the Offered Securities
describing the terms of the proposed Offering.  The Investor acknowledges that the Investor has received certain additional
information regarding the Offering, including pricing information (the “Offering Information”). Such Offering Information
may be provided to the Investor by any means permitted under the Securities Act of 1933, as amended, including through a prospectus
supplement, a free writing prospectus and oral communications.


 


4.2         The
Investor has full right, power, authority and capacity to enter into this Agreement and to consummate the transactions contemplated
hereby and has taken all necessary action to authorize the execution, delivery and performance of this Agreement, and this Agreement
constitutes a valid and binding obligation of the Investor enforceable against the Investor in accordance with its terms, subject
to the effect of applicable bankruptcy, insolvency or similar laws affecting creditors’ rights generally and equitable principles
of general applicability.


 


4.3         The
Investor is knowledgeable, sophisticated and experienced in making, and is qualified to make, decisions with respect to investments
in shares representing an investment decision like that involved in the purchase of the Offered Securities and has, in connection
with its decision to purchase the number of Offered Securities set forth on Schedule I to the Agreement, relied solely upon the
registration statement, the base prospectus, the preliminary term sheet, the Offering Information and any amendments or supplements
thereto and has not relied upon any information provided by the Placement Agents.


 


4.4         The
Investor understands that nothing in the registration statement, the base prospectus, the preliminary term sheet, the Offering
Information and any amendments or supplements thereto, this Agreement or any other materials presented to such Investor in connection
with the purchase and sale of the Offered Securities constitutes legal, tax or investment advice.  The Investor has consulted
such legal, tax and investment advisors as it, in its sole discretion, has deemed necessary or appropriate in connection with its
purchase of Offered Securities.


 


4.5         The
Investor will not, upon the Closing of the transactions contemplated by this Agreement, beneficially own, as calculated in accordance
with Section 13(d) of the Securities Exchange Act of 1934, as amended, in excess of, 19.99% of the shares of Common Stock outstanding.


 


4.6         From
and after obtaining knowledge of the sale of the Offered Securities contemplated hereby, the Investor has not engaged in any purchases
or sales of the securities of the Company (including, without limitation, any Short Sales (as defined herein) involving the Company’s
securities), and has not violated its obligations of confidentiality.  The Investor covenants that it will not engage in any
purchases or sales of the securities of the Company (including Short Sales) or disclose any information about the contemplated
offering (other than to its advisors that are under a legal obligation of confidentiality) prior to the time that the transactions
contemplated by this Agreement are publicly disclosed.  The Investor agrees that it will not use any of the Units acquired
pursuant to this Agreement to cover any short position in the Common Stock if doing so would be in violation of applicable securities
laws.  For purposes hereof, “Short Sales” include, without limitation, all “short sales” as defined
in Rule 200 promulgated under Regulation SHO under the Exchange Act, whether or not against the box, and all types of direct and
indirect stock pledges, forward sales contracts, options, puts, calls, short sales, swaps, “put equivalent positions”
(as defined in Rule 16a-1(h) under the Exchange Act) and similar arrangements (including on a total return basis), and sales and
other transactions through non-US broker dealers or foreign regulated brokers.


 






    	 



    	 



    

 


5.           Survival
of Representations, Warranties and Agreements.  Notwithstanding any investigation made by any party to this Agreement,
all covenants, agreements, representations and warranties made by the Company and the Investor herein shall survive the execution
of this Agreement, the delivery to such Investor of the Offered Securities being purchased and the payment therefor.


 


6.           Notices.  All
notices, requests, consents and other communications hereunder shall be in writing, shall be mailed (A) if within domestic United
States, by first-class registered or certified airmail, or nationally recognized overnight express courier, postage prepaid, or
by facsimile, or (B) if delivered from outside the United States, by International Federal Express or facsimile, and shall be deemed
given (i) if delivered by first-class registered or certified mail domestic, three business days after so mailed, (ii) if delivered
by a nationally recognized overnight carrier, one business day after so mailed, (iii) if delivered by International Federal Express,
two business days after so mailed, (iv) if delivered by facsimile, upon electronic confirmation of receipt and shall be delivered
as addressed as follows: (a) if to the Company, at the office of the Company, 65 West Watkins Mill Road, Gaithersburg, MD  20878,
fax: 301.944.1902, Attention: Douglas J. Swirsky, with copies to Hogan Lovells US LLP, 100 International Drive, Suite 2000, Baltimore,
MD 21202, fax: 410.659.2701, Attention: Asher M. Rubin and William I. Intner; and (b) if to an Investor, at its address on
Schedule I hereto, or at such other address or addresses as may have been furnished to the Company in writing by such Investor.


 


7.           Changes.  This
Agreement may not be modified or amended except pursuant to an instrument in writing signed by the Company and the Investor.


 


8.           Headings.  The
headings of the various sections of this Agreement have been inserted for convenience or reference only and shall not be deemed
to be part of this Agreement.


 


9.           Severability.  In
case any provision contained in this Agreement should be invalid, illegal or unenforceable in any respect, the validity, legality
and enforceability of the remaining provisions contained herein shall not in any way be affected or impaired thereby.


 


10.         Governing
Law.  This Agreement shall be governed by, and construed in accordance with, the internal laws of the State of New
York, without giving effect to the principles of conflicts of law.


 


11.         Counterparts;
Facsimile.  This Agreement may be executed in two or more counterparts, each of which shall constitute an original,
but all of which, when taken together, shall constitute one instrument, and shall become effective when one or more counterparts
have been signed by each party hereto and delivered to the other parties.  Facsimile signatures shall be as effective
as original signatures.


 




    	 



    	 



    

 


Annex
II


 


GENVEC, INC.


 


INVESTOR QUESTIONNAIRE


 


Pursuant to Annex I to the Agreement,
please provide us with the following information:


 


	1. The exact name that your Offered Securities are to be registered in. You may use a nominee name if appropriate:	 	 
	 	 	 
	2. The relationship between the Investor and the registered holder listed in response to item 1 above:	 	 
	 	 	 
	3. The mailing address of the registered holder listed in response to item 1 above:	 	 
	 	 	 
	4. The Social Security Number or Tax Identification Number of the registered holder listed in the response to item 1 above:	 	 
	 	 	 
	5. Name of DTC Participant (broker-dealer at which the account or accounts to be credited with the Shares are maintained):	 	 
	 	 	 
	6. DTC Participant Number:	 	 
	 	 	 
	7. Name of Account at DTC Participant being credited with the Offered Securities:	 	 
	 	 	 
	8. Account Number at DTC Participant being credited with the Offered Securities: