Glufosinate Ammonium Dietary Exposure Assessment DP#: 402741 PC Code: 128850

Page 1 of 27 

### UNITED STA **T ES ENVIRONMENTAL PROTECTION AGENCY**  **WASHINGTON, D.C. 20460**
**OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION**  

### MEMORANDUM Date : 1 9

- JUN
- 2012 SUBJECT: **Glufosinate Ammonium .**  Update of the Revised Acute and Chronic Aggregate

Dietary (Food and Drinking Water) Exposure Assessment in Support of the Petition Propos ing Tolerance s for Residues of Glufosinate Ammonium in/ on Citrus Fruits (Crop Group 10 ), Pome Fruits (Crop Group 11 ), Stone Fruits (Crop Group 12 ), Olives, and Sweet Corn

. **PC Code:** 128850 **DP Barcode:** D 4 02741 **Decision No.:** 402155 **Registration No.:** NA **Petition No.:** 9 E7 604 & 9F7655 **Regulatory Action:** Section 3 **Assessment Type:** Dietary **Case No.:** 7224 **TXR No.:** N A **CAS No.:** 77182

- 82

- 2 **MRID No.:** NA **40 CFR:** §180. 4 73


### FROM : William H. Donovan , Ph.D., Chemist

Risk Assessment Branch V Health Effects Division (HE D ) ( 7509 P) THROUGH: Douglas Dotson , Ph.D., Chemist

Kristi n Rury , MPH, Biolog ist Dietary Exposure Science Advisory Council (DESAC) Health Effects Division (HED ) ( 7509P) TO: Kathry

n Montague, RM Team 23 Sidney Jackson/Barbara Madden, RM Team 05 R egistration D ivision (RD) (7505P) and Katie Wey

ra u ch , Risk Manager Reviewer Tom My ers, Risk Manager Pesticide Re
- Evaluation Division (PRD) (7508P)Glufosinate Ammonium Dietary Exposure Assessment DP#: 402741 PC Code: 128850

Page 2 of 27 

### Executive Summary The purpose of this memorandum is to report the r esults of revised acute and chronic aggregate dietary (food + drinking water) exposure anal ys e s for the herb icide glufosinate ammonium , including all currentl y registered uses and the proposed use s . Revisions were made to the most recent dietary

exposure analy sis f

or glufosinate ammonium (D384486, W. Donovan, 01

- DEC

2010) to includ e updated estimated drinking water concentrations (EDWCs) provided b y EFED (D387412, C. Peck, 30

- MAY

- 2012 ). In these analy se s, the acute and chronic dietary exposure and risk estimates resulting from food and water intake were determined for the general U.S. population and various population subgroups

. A cute and c hronic dietary risk assessment s were conducted using the Dietary Exposure Evaluation Model DEEM

- FCI DTM, Versio n 3.1 0, which uses food consumption data from the U.S. Department of Agriculture’s National Health and Nutrition Examination Survey /“What We Eat in America” (NHANES/WWEI A) dietary survey conducted in 2003

- 2008
. The s e analy ses were performed to support a Section 3 request for use of glufosinate ammonium in/on Citrus Fruits (Crop Group 10 ) , Pome Fruits (Crop Group 11 ), Stone Fruits (Crop Group 12 ), olives, and sweet corn. Acute Dietary (Food + Drinking W ater) Exposure Results and Characterization HED recentl y determined the doses and endpoints for use in human health risk assessments for glufosinate ammonium taking into account all available toxicity studies

. An e ndpoint was identified for assessing acute dietary exposure for only

the female 13

- 49 y ears old population s ubgroup ; therefore, no acute dietary risk assessment was performed for any other population subgroups

. Making use of tolerance level residues, default processing factors and 100% crop treated (% CT) assumptions, an unrefined acute dietary anal ys is (food a nd drinking water) for glufosinate ammonium showed that the females 13

- 49 y ear old population subgroup occupied 39 % of the acute population adjusted dose ( aPAD )

. Chronic Dietary (Food + Drinking W ater) Exposure Results and Characterization The chronic dietary

e xposure assessment for glufosinate ammonium is refined using anticipated residues based on average field trial residue for crops as well as livestock commodities. Percent crop treated information and processing factors, where available , were also used in the assessment. At an EDWC of 9 5 ppb ( based on the rice use) , the **chronic dietary risk estimates are**  **below HED’s**  **level of concern (i.e. <**  **100% of the**  **chronic population adjusted doses (cPAD))** for all population subgroups. T he highest exposed population subgroup was all infants (<1 ye ar old) at 98 % of th e cPAD , and the general US population occupied 39 % of the cPAD

. Potential residues in drinking water account for most of the exposure.Glufosinate Ammonium Dietary Exposure Assessment DP#: 402741 PC Code: 128850

Page 3 of 27 

### Cancer Exposure Results and Characterization HED classified glufosinate ammonium as “ not likely to be c arc inogenic to h umans” based on the absence of significant tumor increases in two adequate rodent carcinogenicity studies; therefore, no human cancer risk assessment was performed. **I. Introduction**  Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to point of departure ( P O D , NOAEL , LOAEL, e.g.) divided by the required uncertainty

or safet y fac tors. For acute and non

- cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Avail able Information on Assessing Exposure from Pesticides, A User’s Guide,” 6/21/2000, web link: http://www.epa.gov/fedrgstr/EPA

- PEST/2000/July /Day

- 12/6061.pdf ; or see SOP 99.6 (8/ 20/99).
**II. Residue Information**  Tolerances: Permanent tolerances are established for residues of glufosinate ammonium i n/on a variet y of commodities at levels ranging from 0. 05 ppm in/on grape to 25 ppm in/on aspirated grain fractions [40 CFR §180. 473 (a)]. Also, rotational crop tolerances are listed under 40 CFR §180. 473(d ) . However, with the exception of teosinte and triticale, these tolerances are limited to livestock feedstuffs, and are accounted for in the dietary burden calculation for livestock

. Triticale is included directly in the dietary

anal ys is; teosinte is not included in DEEM. Residue of Concern : HED previously concluded that the residue s of concern for tolerance enforcement and risk assessment for both plant and livestock commodities are glufosinate ammonium , N
- acet yl

- glufosinate (HOE 099730), and 3

- hy doxy methy lphosphiny l

- propionic acid ( MPP or HOE 061517) (D282757, T. Bloem, 09

- MAY

- 2002). As metabolism studies are available for a variet y of nontransgenic crops (corn, soy bean, apple, and lettuce) and transgenic crops (corn, so ybean, sugar beet, canola, and rice), the results from these metabolism studies may be translated to pome fruit, stone fruit, citrus fruit , olive , and sweet corn. For drinking water, the residue of co ncern is g lufosinate ammonium

. MPP (HOE 061517) is likely less toxic than the parent compound and should not be aggregated with the parent . I f MPP EDWCs are not significantly greater than those for glufosinate (>4

- 5X) , the risk assessment for the parent will be protective of any toxicity associated with exposure to MPP in drinking water , and a quantitative risk assessment for MPP will not be required ( D397644, I . Negron
Encarnacion, 29

- MAR

- 2012 ). Thus, EFED provide d EDWC estimates for both glufosinate ammonium a nd MPP (Section III)

.Glufosinate Ammonium Dietary Exposure Assessment DP#: 402741 PC Code: 128850

Page 4 of 27 

### Residue Data Used for Acute Assessment: Tolerance level residues were used for the acute anal ys is, along with default processing factors, and 100% CT assumptions ( unrefined anal ys is). The following recommended tolerance levels were used for the proposed new use crops: citrus fruit, 0.15 p pm; pome fruit, 0.2 5 ppm; stone fruit, 0.25 ppm; olive, 0.15 ppm; and sweet corn, 0.25 ppm (D372625, I. Negron

- Encarnacion, 31

- AUG

- 2010)

. Residue Data Used for Chronic Assessment: The DEEM

- FCID  chronic anal ys is was performed using anticipated residues ( ARs ) derived from average field trial residue levels , experimentally

determined processing factors , and updated % CT information as summarized in Table 1
. For commodities bearing no detectable residues in the field trials ( e.g. , tree nuts, grapes, apples, citrus, olives , peaches and nectarines ) , the anticipated residue was taken to be 1⁄2 the tolerance level or recommended tolerance level . This is a conservative estimate of the average residue level, but provides a degree of refinement bey ond use of the full tolerance level. See Attachment 5 for dietary burden calculations (from D372625, I. Negron

- Encarnaci on, 31

- AUG

- 2010) and derivation of the AR values for meat, milk, poultry and egg (MMPE) commodities. A search of the USDA PDP database showed no results for glufosinate ammonium for an y commodity within the last five y ears. Therefore, neither fish nor sh ellfish were included in the present anal ys es. Anticipated Residues and Processing Factors : **Table 1 . Anticipated Residues and Processing Factors Used in Chronic Dietary Analysis.**  Commodity Residue Processing Factor Reference Beet, sugar 0.24 0.10 D257628, T. Bloem, 9

- JUL
- 1999 Beet, sugar, molasses 0.24 6.8 Potato, chip 0.19 2.3 Potato, dry and flour 0.19 3.0 Potato, tuber 0.19 1.0 Soy bean (all commodities except oil) 0.77 1.0 D211531, M. Rodriguez, 7

- MAR

- 1996 Soy bean, oil 0.77 0.75 D211531, M. Rodriguez, 7

- MAR

- 1996 Citrus Fruit (CG 10) Incl. juice, oil 0.075 1 1⁄2 recommended tolerance level ; 47915701.der (residue) 47915706.der (PF) Apple ( except juice) Crabapple 0.0 2 5 Apple, dried 8.0 1⁄2 tolerance level; Default PF Apple juice 0.02 5 1 PP8F3607, J. Garbus, 14

- OCT

- 1988 Pear (except juice) 0.155 Pear, dried 6.25 47915702.der (residue) ; Default PF Pear juice 0.155 1 47915702.der (residue) L oquat, quince 0.155 1 47915702.der (residue) ; Default PF Cherry (except juice), apricot 0.15 6 1 47915703.der (residue) Cherry juice 0.15 6 1.5 Default PF Apricot, dried 0.15 6 6 Default PF Peach and nectarine 0.075 1 1⁄2 recommended tolerance level ; 4791570 5 .der (residue) Peach, dried 0.075 7.0 Default PF Plum (except juice) 0.153 1.8 ( dried prune) 47915703.der (residue) ; 47915707.der (PF) Plum

– prune juice 0.153 1.4 Default PF Bushberry subgroup 13B 0.05 5 1 D271110, T. Bloem, 20

- JUN
- 2002 Tree Nuts CG 14 0.05 1 1⁄2 tolerance level; default PFGlufosinate Ammonium Dietary Exposure Assessment DP#: 402741 PC Code: 128850

Page 5 of 27 Commodity Residue Processing Factor Reference Corn, field (all commodities except syrup) 0.05 1 D211531, M. Rodriguez, 7

- MAR

- 1996 Corn, field, syrup 0.05 1.5 Default PF Corn, sweet 0.11 1 47828201.der & 47828202.der Rice (all commodities except bran) 0.20 1.3 45204406.der (residues) 45204408.der (PF) Rice, bran 0.20 0.9 45204408.der (PF) Triticale, flour 0.20 1 1⁄2 tolerance level; default PF Rapeseed, oil 0.20 1 1⁄2 tolerance level; default PF Beef*, meat 0 .0059 1

See Attachment 5 Beef*, meat, dried 0.0059 1.92 Beef*, meat byproducts 0.96 1 Beef*, fat 0.065 1 Beef*, kidney 0.30 1 Beef*, liver 0.96 1 Pork, meat 0.00059 1 Pork, skin 0.096 1 Pork, meat byproducts 0.096 1 Pork, fat 0. 0065 1 Pork, kidney 0.03 1 Pork, liver 0.096 1 Milk (all fractions) 0.0068 1 Meat, game 0.0059 1 Rabbit, meat 0.0059 1 Chicken**, meat 0.0071 1 Chicken**, liver 0.014 1 Chicken**, meat byproducts 0.046 1 Chicken**, fat 0.0071 1 Chicken**, skin 0.0071 1 Egg (all fractions) 0.0071 1 Water 0.095 (rice) 1 D387412 , C. Peck, 30

- MAY

- 201 2 Banana/plantain 0.08 1 D172878, M. Rodriguez Banana/plantain, dried 0.08 3.9 Default PF Cottonseed, oil 1.12 0.01 45089303.der (residues) 45089302.der (PF) Grape (all except raisin) 0.025 1 1⁄2 tolerance level; default PF Juice PF: PP8F3607, J. Garbus, 14

- OCT

- 1988 Grape, raisin 0.025 1 PP8F3607, J. Garbus, 14

- OCT

- 1988 (PF) Olive 0.075 1 1⁄2 recommended tolerance level ; 47915704.der Olive oil 0.075 0.6 47915708.der *Same for Goat, Horse, and Sheep **Same for Turkey and Poultry 

### Percent Crop Treated : A Screening Level Usage Anal ys is (SLUA) for gl ufosinate ammonium was provided b y BEAD for an anal ys is run on 19

- MAR

- 2012 (see Attachment 6 )

. The average % CT values used for estimating chronic dietary exposure s are listed in T able 2
. One hundred percent crop treated value s were used for all proposed new uses since no projected percent cropGlufosinate Ammonium Dietary Exposure Assessment DP#: 402741 PC Code: 128850

Page 6 of 27 

### treated values were provided. The acute analy sis was unrefined, assuming 100% CT for all commodities. **Table 2. Average percent crop treated values used in the chronic dietary analysis .**  Crop Avg % CT Crop Avg %CT Almond 1 5 Walnut 10 Blueberry 5 Canola/Rapeseed 25 Corn, field 5 Cotton 5 Grape 1 5 Filbert 10 Pecan 1 Pistachio 20 Potato 10 Rice 1 Soy bean 1 

### III. **Drinking Water Data** The drinking water residues used in the dietary risk assessment were provided by EFED ( DP 3 87412 , C

. Peck , 5/30/2012 ) and incorporated directly into the dietary

assessment. Water residues were incorporated in the DEEM

- FCID into the food categories “water, direct, all sources” and “water, indirect, all sources.” EFED estimated acute EDWCs for glufosinate

- ammonium and MPP using the refined Tier I Rice Model and Pesticide Flooded Application Model (PFAM) [version 0.70] without the index reservoir. T o estimate chronic EDWCs , th e acute concentrations from PFAM without the index reservoir were allowed to degrade over a 365

- day period, using the aerobic aqu atic degradation half

- lives, and the average concentration over the one

- year period was calculated. Using this method, chronic values are approximately 76% and 3% lower than the acute values for glufosinate

- ammonium and MPP, respectively

. Previous anal ys es from EFED demonstrated that the maximum acute and chronic EDWCs for glufosinate ammonium arise from the rice uses; these values being nearl y an order of magnitude higher than the values from any other crop use of glufosinate ammonium (DP 3 72624 , C

. Peck , 6/22/2010 & DP 3 81992 , C

. Peck , 10/20/2010) . Thus, EFED conducted a comprehensive refinement of the drinking water assessment for the rice use of glufosinate ammonium, with the expectation that the resulting values should be protective of other uses

. Table 3 summarizes t he PFAM EDW Cs for glufosinate ammonium and MPP based on the rice use patterns, as provided by EFED
. Most of the application scenarios result in lower values for MPP than for glufosinate ammonium, although the maximum chronic EDWC for MPP is approximately

2x higher than the corresponding value for glufosinate ammonium. Because glufosinate ammonium is considerabl y more toxic than MPP, and these compounds have sufficient differences i n toxicity that precludes aggregation, parent EDWC s are protective of MPP EDWCs. Accordingl y, the acute and chronic dietary anal ys es included the highest glufosinate ammonium EDWCs of 390 and 95 ppb, respectivel y.Glufosinate Ammonium Dietary Exposure Assessment DP#: 402741 PC Code: 128850

Page 7 of 27 

### Table **3. EDWCs for glufosinate**  **- ammonium use on rice**  **derived using PFAM (maximum values ap**  **pear in bold) Use rate, Number of apps, retreatm**  **ent interval, water holding period**  **, application tim ing**  **Acute EDWC (**  **μg/L )**  **Chronic EDWC**  **1 (**  **μg/L )**  **4” 8”**  **4” 8”**  Glufosinate

- ammonium 1.46 lbs ai/acre, 1, NA, 7 days, dry 173 86 42 21 0.73 lbs ai/acre, 2, 10, 30, dry and flooded 2 NA 320 NA 78 0.73 lbs ai/acre, 2, 10, 55, dry and flooded 2 **390** NA **95** NA 0.89 lbs ai/acre, 1, NA, 7 days, dry 106 53 26 13 0.66 lbs ai/acre, 1, NA, 7 days, dry 74 38 18 9 0. 44 lbs ai/acre, 2, 10 days, 7 days, dry 88 45 22 11 0.44 lbs ai/acre, 2, 10 days, 7 day s, flooded NA 375 NA 92 MPP 1.46 lbs ai/acre, 1, NA, 7 days, dry 5.7 2.9 5.5 2.8 0.73 lbs ai/acre, 2, 10, 30, dry and flooded 2 NA 88 NA 85 0.73 lbs ai/acre, 2, 10, 55, dry and flooded 2 183 NA 177 NA 0.89 lbs ai/acre, 1, NA, 7 days, dry 3.5 1.8 3.4 1.7 0.66 lbs ai/acre, 1, NA, 7 days, dry 2.2 1.1 2.1 1.1 0. 44 lbs ai/acre, 2, 10 days, 7 days, dry 3.0 1.5 2.9 1.5 0.44 lbs ai/acre, 2, 10 days, 7 day s, flooded NA 45 NA 44 1. Chronic EDWC calculated by taking acute EDWC and allowing it to degrade for 365 days, using the aerobic aquatic degradation half

- life, and then taking the average value over the 365

- day period. 2. For this scenario the first application is made to a dry field, while the second application is made to a flooded field. NA

– not allowed. 

### IV **. DEEM**  **- FCIDTM Program and Consumption Information**  Glufosinate ammonium acute and chronic dietary e xposure assessments were conducted using the Dietary

Exposure Evaluation Model software with the Food Commodity I ntake D atabase DEEM
- FCIDTM, Version 3.10 which incorporates consumption data from USDA’s National Health a nd Nutrition Examination Survey /“What We Eat in America” (NHANES/WWEI A) dietary survey conducted in 2003

- 2008 . The 2 003

- 2008 data are based on the reported consumption of individuals over two non - consecutive survey day s. Foods “as consumed” (e.g., apple pie) are linked to EPA

- defined food commodities (e.g. apples, peeled fruit

- cooked; fresh or N/S; baked; or wheat fl our - cooked; fresh or N/S, baked) using publicl y available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute exposure assessment are retained as individual consumption events. Based on anal ys is of the 2003

- 2008 WWEI A consumption data, which took into account dietary patterns and survey

respondents, HED concluded that it is most appropriate to report ri sk for the following population subgroups: the general U.S. population, all infants (<1 y ear old), children 1

- 2, children 3

- 5, children 6

- 12, y outh 13

- 19, adults 20

- 49, females 13

- 49, and adults 50+ y ears old. For chronic dietary

exposure assessment, an e stimate of the residue level in each food or food

form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average dail y consumption estimate for that food/food form to produce a residue intake estimate. The resulting re sidue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the totalGlufosinate Ammonium Dietary Exposure Assessment DP#: 402741 PC Code: 128850

Page 8 of 27 

### average estimated exposure. Exposure is expressed in mg/kg bod y weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup. For acute exposure assessments, individual one

- day food consumption data are used on an individual

- by

- individual basis. The reported consumption amounts of each food item c an be multiplied by

a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment. The res ulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., onl y those who reported eating relevant commodities/food forms) and a per

- capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy , per capita exposure and risk are reported for all tiers of anal ysis. However, an y significant differences in user vs. per capita exposure and risk are specifically identified and noted in the risk assessment

. **V. Toxicological Information**  I n a meeting held 10

- JUN
- 2010 , the Toxicology Science Advisory

Council (ToxSAC) updated the glufosinate ammonium doses and endpoints (J. Kidwell, Glufosinate Ammonium ToxSAC Report, 29

- JUL
- 2010). No endpoint was identified in the toxicological data base to estimate risk to the general population from a single dose administration of gl ufosinate ammonium

. However, an acute dietary endpoint for females 13

- 50 y ears old was selected based on fetal deaths in the develop mental toxicity

study in rabbits, resulting in an aPAD of 0.063 mg/kg. For chronic dietary exposure, a weight of evidence approach from several studies was used to select a NOAEL of 6 mg /kg/day together with a total uncertainty factor of 1000x

. HED class ified glufosinate ammonium as “not likely to be carcinogenic to humans.” As such, a cancer dietary risk assessment is not warranted. The doses relevant to dietary exposure are summarized in Table 4 , below. **Table 4**  **. Summary of Toxicological Doses and Endpoints for Glufosinate Ammonium**  **for Use in Dietary Risk Assessments**  Exposure/ Scenario Point of

Departure Uncertainty/

FQPA Safety Factors RfD, PAD, Level

of Concern for Risk Assessment Study and Toxicological Effe cts Ac ute Dietary ( Fem ales 13

- 50 only) NOAEL =

6.3 mg/kg UF A =10X

UF H =10X FQPA SF=1X Ac ute RfD

=0.0 6 3 mg/kg/day aPAD = 0.063 mg/kg Developmental Toxicity Study in Rabbits

LOAEL = 20 mg /kg/day based on increased fetal death

.

Ac ute Dietary ( General Population including infants and children ) NA NA NA No endpoint attributable to a single exposure was identified for the general population, including infants and children.Glufosinate Ammonium Dietary Exposure Assessment DP#: 402741 PC Code: 128850

Page 9 of 27 **Table 4**  **. Summary of Toxicological Doses and Endpoints for Glufosinate Ammonium**  **for Use in Dietary Risk Assessments**  Exposure/ Scenario Point of

Departure Uncertainty/

FQPA Safety Factors RfD, PAD, Level

of Concern for Risk Assessment Study and Toxicological Effe cts Chronic Dietary (All Populations) NOAEL=

6.0 mg/kg/day UF A = 10x

UF H =10x UF S = 10x FQPA SF= 1x Total UF = 1000 Chronic RfD

=0.006 mg/kg/day cPAD =0.006 mg/kg/day “Weight of Evidence” approach from 4

studies, including DNT. LOAEL is based on brain glutamine synthetase inhibition, alterations in the electrocardiogram, and changes in brain mo rphom etry at PND 72. Cancer (oral, dermal, inhalation) Classification: “Not likely to be Carcinogenic to Humans” based on the absence of significant

tumor increases in two adequate rodent carcinogenicity studies. Point of Departure (POD) = A data point or an estimated point that is derived from observed dose

- response data and used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no ob served adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A = extrapolation from animal to human (interspecies). UF H = potential v aria tion in sensitivity among members of the human population (intraspecies). UF S = use of a short

- term study for long

- term risk assessment. F QPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD = reference dose. N/A = not applicable.


### V **I .**  **Results/Discussion** As stated above, for acute and chronic dietary assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM

- FCID  anal ys es estimate the dietary exposure of the US population and various population subgroups. The results reported in Table 5 (below) are fo r the general US population (total), all infants <1, children 1

- 2, children 3

- 5, children 6

- 12, y ouths 13

- 19, females 13

- 49, adults 20

- 49, and adults 50+ ye ars old for chronic exposure ; while for acute exposure onl y the female 13

- 49 y ears old population su bgroup is reported. Results of Acute Dietary

Exposure Analy sis : An unrefined acute dietary risk assessment for glufosinate ammonium at the EDWC of 390 ppb showed that **acute dietary risk estimates**  **are below**  **HED’s level of concern (i.e.**  **< 100%**  **a PAD**  **)** for females 13

- 49 y ears old ( 3 9 % aPAD). Results of Chronic Dietary Exposure Analy sis : T he chronic dietary risk assessment for glufosinate ammonium at the EDWC of 95 ppb showed that **chronic dietary risk estimates are**  **below HED**  **’s level of concern (i.e.**  **< 100%**  **cPAD)** for all population subgroups; in particular, All infants (<1 year old), the highest exposed population subgroup ( 98 % of the cPAD) , and the US Population ( 39 % of the cPAD).
The results of the dietary exposure anal ys e s are reported in Table 5
.Glufosinate Ammonium Dietary Exposure Assessment DP#: 402741 PC Code: 128850

Page 10 of 27 **T able**  **5 .**  **Summary of Dietary Exposure and Risk for Glufosinate A**  **mmo nium**  **[ Acute EDWC of 390**  **ppb ,** 

**Chronic EDWC of 9 5 ppb**  **] .**  Population Subgroup 1 **DEEM Acute Dietary Analysis, 95**  **th Percentile**  **DEEM Chronic Dietary Analysis Exposure**  **(m g/kg/day)**  **% aPAD Exposure**  **(m g/kg/day)**  **% cPAD** General U.S. Population

NA 2 NA 2 0.0 02324 39 **All Infants (< 1 year old) 0.**  **0 05887**  **98** Children 1

- 2 y ears old 0.0 04387 73 Children 3

- 5 y ears old 0. 003447 57 Children 6

- 12 y ears old 0.0 02261 38 Youth 13

- 19 y ears old 0.00 1706 28 Ad ults 20

- 49 y ears old 0.0 02203 37 Ad ults 50

- 99 years old 0.0 02202 37 Fem ales 13

- 49 y ears old **0.0 24**  **401 39**  0.0 02195 37 1 Values for the population with the highest risk for each type of risk assessment are **bolded**
. 2 NA = Not Applicable; no acute dietary endpoint was identified for these population subgroups

. 

### VII. **Characterization of Inputs/Outputs** The acute dietary

exposure assessment for glufosinate ammonium is un refined , making use of tolerance level residue s an d 100% crop treated assumptions for all crops and livestock commodities. This conservative anal ys is proved adequate, as the onl y relevant population subgroup, females 13

- 49 y ears old, occupied 39 % aP AD. The chronic dietary

exposure assessment for glufosinate ammonium is refined using anticipated residues based on average field trial residue levels for plant raw agricultural commodities ( RACs ) , % CT information where available, and experimentally

- determined processing factors. Additionally , ARs in livestock commodities were calculated assuming dietary burdens computed from average field trial residue levels in the feed items together with a reasonably balanced diet as specified in the most recent guidance document ( Table 1 Feedstuffs ( June 2008 ))

. The assessment could be further refined if projected percent crop treated informat ion became available for the proposed new crop uses.Glufosinate Ammonium Dietary Exposure Assessment DP#: 402741 PC Code: 128850

Page 11 of 27 

### VI **I I**  **. Conclusions**  T he primary

contributor to dietary

exposure is drinking water. For the acute exposure scenario, females 1 3

- 49 y ears old occupied 39 % aPAD, and are below HED’s level of concern using an unrefined anal ys is. W hen using chronic EDWC levels determined b y EFED based on the rice use, risk levels below HED’s level of concern are calculated for the chronic exposure scenario for all population subgroups

. The highest exposed population subgroup, all infants (<1 y e ar old), results in a % cP AD value of 98 , wh ile the US Population occupies 3 9% cPAD.
**IX .**  **List of Attachments** Attachment 1 : Acute Food plus Water Residue In put File at an EDWC of 390 ppb Attachment 2 : Acute Results File at an EDWC of 390 ppb Attachment 3 : Chronic Food plus Water Residue Input File at an EDWC of 95 ppb Attachment 4 : Chronic Results File at an EDWC of 95 ppb Attachment 5 : Dietary

Burden and Livestock AR Calculations for Glufosinate Ammonium Attachment 6 : Glufosinate Ammonium SL UA dated 19

- MAR

- 2012Glufosinate Ammonium Dietary Exposure Assessment DP#: 402741 PC Code: 128850

Page 12 of 27 

### Attachme **nt 1 :**  **Acute Food plus Water Residue Input File**  **at an**  **EDWC of 390**  **ppb**
Filename: C: \ Documents and Settings \ wdonovan \ My Documents \ CalendexWWEIAFCID \ 128850a.R08 Chemical: glufosinate ammonium RfD(Chronic): .006 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): .063 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Date created/last modifi ed: 06
- 19
- 2012/08:02:29 Program ver. 3.10 Comment: acute EDWC 390 ppb 30may12

-------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0101052000 1A Beet, sugar 0.900000 1.000 1.000 0101052001 1A Beet, sugar - babyfood 0.900000 1.000 1.000 0101053000 1A Beet, sugar, molasses 5.000000 1.000 1.000 0101053001 1A Beet, sugar, molasses
- babyfood 5.000000 1.000 1.000 0103296000 1C Potato, chips 1.600000 1.000 1.000 0103297000 1C Potato, dry (granules/ flakes) 2.000000 1.000 1.000 0103297001 1C Potato, dry (granules/ flakes)

- b 2.000000 1.000 1.000 0103298000 1C Potato, flour 2.000000 1.000 1.0 00 0103298001 1C Potato, flour
- babyfood 2.000000 1.000 1.000 0103299000 1C Potato, tuber, w/peel 0.800000 1.000 1.000 0103299001 1C Potato, tuber, w/peel

- babyfood 0.800000 1.000 1.000 0103300000 1C Pota to, tuber, w/o peel 0.800000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel

- babyfood 0.800000 1.000 1.000 0600347000 6 Soybean, seed 2.000000 1.000 1.000 0600349000 6 Soybean, soy milk 2.000000 1.000 1.000 0600349001 6 Soybean, soy milk
- babyfood or in 2.000000 1.000 1.000 0600350000 6 Soybean, oil 2.000000 1.000 1.000 0600350001 6 Soybean, oil
- babyfood 2.000000 1.000 1 .000 0603348000 6C Soybean, flour 2.000000 1.000 1.000 0603348001 6C Soybean, flour
- babyfood 2.000000 1.000 1.000 1001106000 10A Citron 0.150000 1.000 1.000 1001107000 10A Citrus hybrids 0.150000 1.000 1.000 1001108000 10A Citrus, oil 0.150000 1.000 1.000 1001240000 10A Orange 0.150000 1.000 1.000 1001241000 10A Orange, juice 0.150000 1.800 1.000 1001241001 10A Orange, juice
- babyfood 0.150000 1.800 1.000 1001242000 10A Orange, peel 0.150000 1.000 1.000 1001369000 10A Tangerine 0.150000 1.00 0 1.000 1001370000 10A Tangerine, juice 0.150000 2.300 1.000 1002197000 10B Kumquat 0.150000 1.000 1.000 1002199000 10B Lemon 0.150000 1.000 1.000 1002200000 10B Lemon, juice 0.150000 2.000 1.000 1002200001 10B Lemon, juice
- babyfood 0.150000 2.000 1.000 1002201000 10B Lemon, peel 0.150000 1.000 1.000 1002206000 10B Lime 0.150000 1.000 1.000 1002207000 10B Lime, juice 0.150000 2.000 1.000 1002207001 10B Lime, juice
- babyfood 0.150000 2.000 1.000 1003180000 10C Grapefruit 0.150000 1. 000 1.000 1003181000 10C Grapefruit, juice 0.150000 2.100 1.000 1003307000 10C Pummelo 0.150000 1.000 1.000 1100007000 11 Apple, fruit with peel 0.250000 1.000 1.000 1100008000 1 1 Apple, peeled fruit 0.250000 1.000 1.000 1100008001 11 Apple, peeled fruit
- babyfood 0.250000 1.000 1.000 1100009000 11 Apple, dried 0.250000 8.000 1.000 1100009001 11 Apple, dried
- babyfood 0.250000 8.000 1.000 1100010000 11 Apple, juice 0.250000 1.300 1.000 1100010001 11 Apple, juice
- babyfood 0.250000 1.300 1.000 1100011000 11 Apple, sauce 0.250000 1.000 1.000 1100011001 11 Apple, sauce
- babyfood 0.250000 1.000 1.000 1100129000 11 Crabapple 0.250000 1.000 1.000 1100210000 11 Loquat 0.250000 1.000 1.000 1100266000 11 Pear 0.250000 1.000 1.000 1100266001 11 Pear
- babyfood 0.250000 1.000 1.000 1100267000 11 Pear, dried 0.250000 6.250 1.000 1100268000 11 Pear, jui ce 0.250000 1.000 1.000 1100268001 11 Pear, juice
- babyfood 0.250000 1.000 1.000 1100310000 11 Quince 0.250000 1.000 1.000 1201090000 12A Cherry 0.250000 1.000 1.000Glufosinate Ammonium Dietary Exposure Assessment DP#: 402741 PC Code: 128850

Page 13 of 27 1201090001 12A Cherry
- babyfood 0.250000 1.000 1.000 1201091000 12A Cherry, juice 0.250000 1.500 1.000 1201091001 12A Cherry, juice
- babyfood 0.250000 1.500 1.000 1202012000 12B Apricot 0.250000 1.000 1.000 1202012001 12B Apricot
- babyfood 0.250000 1.000 1.000 1202013000 12B Apricot, dried 0.250000 6.000 1.000 1202014000 12B Apricot , juice 0.250000 1.000 1.000 1202014001 12B Apricot, juice
- babyfood 0.250000 1.000 1.000 1202230000 12B Nectarine 0.250000 1.000 1.000 1202260000 12B Peach 0.250000 1.000 1.000 1202260001 12B Peach
- babyfood 0.250000 1.000 1.000 1202261000 12B Peach, dried 0.250000 7.000 1.000 1202261001 12B Peach, dried
- babyfood 0.250000 7.000 1.00 0 1202262000 12B Peach, juice 0.250000 1.000 1.000 1202262001 12B Peach, juice
- babyfood 0.250000 1.000 1.000 1203285000 12C Plum 0.250000 1.000 1.000 1203285001 12C Plum
- babyfood 0.250000 1.000 1.000 1203286000 12C Plum, prune, fresh 0.250000 1.000 1.000 1203286001 12C Plum, prune, fresh
- babyfood 0.250000 1.000 1.000 1203287000 12C Plum , prune, dried 0.250000 5.000 1.000 1203287001 12C Plum, prune, dried
- babyfood 0.250000 5.000 1.000 1203288000 12C Plum, prune, juice 0.250000 1.400 1.000 1203288001 12C Plum, prune, juice
- babyfood 0.250000 1.400 1.000 1302057000 13B Blueberry 0.150000 1.000 1.000 1302057001 13B Blueberry
- babyfood 0.150000 1.000 1.000 1302136000 13B Currant 0.150000 1.000 1 .000 1302137000 13B Currant, dried 0.150000 1.000 1.000 1302149000 13B Elderberry 0.150000 1.000 1.000 1302174000 13B Gooseberry 0.150000 1.000 1.000 1302191000 13B Hu ckleberry 0.150000 1.000 1.000 1304175000 13D Grape 0.050000 1.000 1.000 1304176000 13D Grape, juice 0.050000 1.200 1.000 1304176001 13D Grape, juice
- babyfood 0.050000 1.200 1.000 1304179000 13D Grape, wine and sherry 0.050000 1.000 1.000 1400003000 14 Almond 0.100000 1.000 1.000 1400003001 14 Almond
- babyfood 0.100000 1.000 1.000 1400004000 14 Almond, oil 0.100000 1.000 1.000 1400004001 14 Almond, oil
- babyfood 0.100000 1.000 1.000 1400059000 14 Brazil nut 0.100000 1.000 1.000 1400068000 14 Butternut 0.100000 1.000 1.000 1400081000 14 Cashew 0.100000 1.000 1.000 1400092000 14 Chestnut 0.100000 1.000 1.000 1400155000 14 Hazelnut 0.100000 1.000 1.000 1400156000 14 Hazelnut, oil 0.100000 1.000 1.000 1400185000 14 Hickory nut 0.100000 1.000 1.000 1400213000 14 Macadamia nut 0.100000 1.00 0 1.000 1400269000 14 Pecan 0.100000 1.000 1.000 1400282000 14 Pistachio 0.100000 1.000 1.000 1400391000 14 Walnut 0.100000 1.000 1.000 1500120000 15 Corn, field, flour 0.200000 1.000 1.000 1500120001 15 Corn, field, flour
- babyfood 0.200000 1.000 1.000 1500121000 15 Corn, field, meal 0.200000 1.000 1.000 1500121001 15 Corn, fie ld, meal
- babyfood 0.200000 1.000 1.000 1500122000 15 Corn, field, bran 0.200000 1.000 1.000 1500123000 15 Corn, field, starch 0.200000 1.000 1.000 1500123001 15 Corn, field, starch
- babyfood 0.200000 1.000 1.000 1500124000 15 Corn, field, syrup 0.200000 1.500 1.000 1500124001 15 Corn, field, syrup
- babyfood 0.200000 1.500 1.000 1500125000 15 Corn, field, oil 0.200000 1.000 1.000 1500125001 15 Corn, field, oil
- babyfood 0.200000 1.000 1.000 1500127000 15 Corn, sweet 0.250000 1.000 1.000 1500127001 15 Corn, sweet
- babyfood 0.250000 1.000 1.000 1500323000 15 Rice, w hite 1.000000 1.000 1.000 1500323001 15 Rice, white
- babyfood 1.000000 1.000 1.000 1500324000 15 Rice, brown 1.000000 1.000 1.000 1500324001 15 Rice, brown
- babyfood 1.000000 1.000 1.000 1500325000 15 Rice, flour 1.000000 1.000 1.000 1500325001 15 Rice, flour
- babyfood 1.000000 1.000 1.000 1500326000 15 Rice, bran 1.000000 1.000 1.00 0 1500326001 15 Rice, bran
- babyfood 1.000000 1.000 1.000 1500381000 15 Triticale, flour 0.400000 1.000 1.000Glufosinate Ammonium Dietary Exposure Assessment DP#: 402741 PC Code: 128850

Page 14 of 27 1500381001 15 Triticale, flour
- babyfood 0.400000 1.000 1.000 2001319000 20A Rapes eed, oil 0.400000 1.000 1.000 2001319001 20A Rapeseed, oil
- babyfood 0.400000 1.000 1.000 2003128000 20C Cottonseed, oil 4.000000 1.000 1.000 2003128001 20C Cottonseed, oil
- babyfood 4.000000 1.000 1.000 3100044000 31 Beef, meat 0.150000 1.000 1.000 3100044001 31 Beef, meat
- babyfood 0.150000 1.000 1.000 3100045000 31 Beef, meat, dried 0.150000 1.920 1.000 3100046000 31 Beef, meat byproducts 6.000000 1.000 1.000 3100046001 31 Beef, meat byproducts
- babyfood 6.000000 1.000 1.000 3100047000 31 Beef, fat 0.400000 1.000 1.000 3100047001 31 B eef, fat
- babyfood 0.400000 1.000 1.000 3100048000 31 Beef, kidney 6.000000 1.000 1.000 3100049000 31 Beef, liver 6.000000 1.000 1.000 3100049001 31 Beef, liver
- babyfood 6.000000 1.000 1.000 3200169000 32 Goat, meat 0.150000 1.000 1.000 3200170000 32 Goat, meat byproducts 6.000000 1.000 1.000 3200171000 32 Goat, fat 0.400000 1.000 1.000 3200172000 32 Goat, kidney 6.000000 1.000 1.000 3200173000 32 Goat, liver 6.000000 1.000 1.000 3300189000 33 Horse, meat 0.150000 1.000 1.000 3400290000 34 Pork, meat 0.150000 1.000 1.000 3400290001 34 Pork, meat
- babyfood 0.150000 1.000 1.000 3400291000 34 Pork, skin 6.000000 1.000 1.000 3400292000 34 Pork, meat byproducts 6.000000 1.000 1.000 3400292001 34 Pork, meat byproducts
- babyfood 6.000000 1.000 1.000 3400293000 34 Pork, fat 0.400000 1.000 1.000 3400293001 34 Pork, fat
- babyfood 0.400000 1.0 00 1.000 3400294000 34 Pork, kidney 6.000000 1.000 1.000 3400295000 34 Pork, liver 6.000000 1.000 1.000 3500339000 35 Sheep, meat 0.150000 1.000 1.000 3500339001 35 Sheep, meat
- babyfood 0.150000 1.000 1.000 3500340000 35 Sheep, meat byproducts 6.000000 1.000 1.000 3500341000 35 Sheep, fat 0.400000 1.000 1.000 3500341001 35 Sheep, fat
- babyfood 0.400000 1.000 1.000 3500342000 35 Sheep, kidney 6.000000 1.000 1.000 3500343000 35 Sheep, liver 6.000000 1.000 1.000 3600222000 36 Milk, fat 0.150000 1.000 1.000 3600222001 36 Milk, fat
- baby food/infant formu 0.150000 1.000 1.000 3600223000 36 Milk, nonfat solids 0.150000 1.000 1.000 3600223001 36 Milk, nonfat solids
- baby food/in 0.150000 1.000 1.000 3600224000 36 Milk, water 0.150000 1.000 1.000 3600224001 36 Milk, water
- babyfood/infant form 0.150000 1.000 1.000 3600225001 36 Milk, sugar (lactose)
- baby food/ 0.150000 1.000 1.000 3800221000 38 Meat, game 0.150000 1.000 1.000 3900312000 39 Rabbit, meat 0.150000 1.000 1.000 4000093000 40 Chicken, meat 0.150000 1.000 1.000 4000093001 40 Chicken, meat
- babyfood 0.150000 1.000 1.000 4000094000 40 Chicken, liver 0.600000 1.000 1.000 4000095000 40 Chicken, meat byproducts 0.600000 1.000 1.000 4000095001 40 Chicken, meat byproducts
- babyfoo 0.600000 1.000 1.000 40000960 00 40 Chicken, fat 0.150000 1.000 1.000 4000096001 40 Chicken, fat
- babyfood 0.150000 1.000 1.000 4000097000 40 Chicken, skin 0.600000 1.000 1.000 4000097001 40 Chicken, skin
- bab yfood 0.600000 1.000 1.000 5000382000 50 Turkey, meat 0.150000 1.000 1.000 5000382001 50 Turkey, meat
- babyfood 0.150000 1.000 1.000 5000383000 50 Turkey, liver 0.60000 0 1.000 1.000 5000383001 50 Turkey, liver
- babyfood 0.600000 1.000 1.000 5000384000 50 Turkey, meat byproducts 0.600000 1.000 1.000 5000384001 50 Turkey, meat byproducts
- babyfood 0.600000 1.000 1.000 500038 5000 50 Turkey, fat 0.150000 1.000 1.000 5000385001 50 Turkey, fat
- babyfood 0.150000 1.000 1.000 5000386000 50 Turkey, skin 0.600000 1.000 1.000 5000386001 50 Turkey, skin
- babyfood 0.600000 1.000 1.000 6000301000 60 Poultry, other, meat 0.150000 1.000 1.000 6000302000 60 Poultry, other, liver 0.600000 1.000 1.000 6000303000 60 Poultry, other, meat byproducts 0.6 00000 1.000 1.000 6000304000 60 Poultry, other, fat 0.150000 1.000 1.000 6000305000 60 Poultry, other, skin 0.600000 1.000 1.000 7000145000 70 Egg, whole 0.150000 1.000 1.000Glufosinate Ammonium Dietary Exposure Assessment DP#: 402741 PC Code: 128850

Page 15 of 27 70 00145001 70 Egg, whole
- babyfood 0.150000 1.000 1.000 7000146000 70 Egg, white 0.150000 1.000 1.000 7000146001 70 Egg, white (solids)
- babyfood 0.150000 1.000 1.000 7000147000 70 Egg, yolk 0.150000 1.000 1.000 7000147001 70 Egg, yolk
- babyfood 0.150000 1.000 1.000 8601000000 86A Water, direct, all sources 0.390000 1.000 1.000 8602000000 86B Water, indirect, all sources 0 .390000 1.000 1.000 9500023000 O Banana 0.300000 1.000 1.000 9500023001 O Banana
- babyfood 0.300000 1.000 1.000 9500024000 O Banana, dried 0.300000 3.900 1.000 9500024001 O Banana, dried
- babyfood 0.300000 3.900 1.000 9500177000 O Grape, leaves 0.050000 1.000 1.000 9500178000 O Grape, raisin 0.050000 4.300 1.000 9500235000 O Olive 0.150000 1.000 1.000 9500236000 O Olive, oil 0.150000 1.000 1.000 9500283000 O Plantain 0.300000 1.000 1.000 9500284000 O Plantain, dried 0.300000 3.900 1.000Glufosinate Ammonium Dietary Exposure Assessment DP#: 402741 PC Code: 128850

Page 16 of 27 

### Attachment 2 **: Acute**  **Results File at an**  **EDWC of 390**  **ppb.**

Ver. 3.10 DEEM - FCID ACUTE Analysis for GLUFOSINATE AMMONIUM NHANES 2003
- 2008 Residue file: 128850a.R08 Adjustment factor #2 NOT used. Analysis Date: 06
- 19
- 2012/09:29:22 Residue file dated: 06

- 19
- 2012/08:02:29 Two - Day Average Results Reported RAC/FF intake summed over 24 hours Run Comment: "acute EDWC 390 ppb 30may12"

=============================================================================== Summary calculations
-- per capita: 95th Percentile 99th Percentile 99.9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- -------- Female 13
- 49: 0.024401 38.73 0.033361 52.95 0.043600 69.21Glufosinate Ammonium Dietary Exposure Assessment DP#: 402741 PC Code: 128850

Page 17 of 27 

### Attachment 3: Chronic Food plus Water Resi **due Input File at an**  **EDWC of 95**  **ppb**
Filename: C: \ Documents and Settings \ wdonovan \ My Documents \ CalendexWWEIAFCID \ 128850c.R08 Chemical: glufosinate ammonium RfD(Chronic): .006 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): .063 mg/kg bw/day NOEL(Acute ): 0 mg/kg bw/day Date created/last modified: 05

- 29
- 2012/12:14:56 Program ver. 3.10 Comment: 95 ppb EDWC, 2012 SLUA

-------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0101052000 1A Beet, sugar 0.240000 0.100 1.000 avg re

Full comment: avg res from fld trl and proc fact (D257628) 0101052001 1A Beet, sugar
- babyfood 0.240000 0.100 1.000 avg re

Full co mment: avg res from fld trl and proc fact (D257628) 0101053000 1A Beet, sugar, molasses 0.240000 6.800 1.000 avg re

Full comment: avg res from fld trl and proc fact (D257628) 0101053001 1A Beet, sugar, molasses
- babyfood 0.240000 6.800 1.000 avg re

Full comment: avg res from fld trl and proc fact (D257628) 0103296000 1C Potato, chips 0.190000 2.300 0.100 avg re

Full comment: avg res from fld trl and proc factor (D2576 28) 0103297000 1C Potato, dry (granules/ flakes) 0.190000 3.000 0.100 avg re

Full comment: avg res from fld trl and proc factor (D257628) 0103297001 1C Potato, dry (granules/ flakes)

- b 0.190000 3.000 0.100 avg re

F ull comment: avg res from fld trl and proc factor (D257628) 0103298000 1C Potato, flour 0.190000 3.000 0.100 avg re

Full comment: avg res from fld trl and proc factor (D257628) 0103298001 1C Potato, flour
- babyfood 0.190000 3.000 0.100 avg re

Full comment: avg res from fld trl and proc factor (D257628) 0103299000 1C Potato, tuber, w/peel 0.190000 1.000 0.100 avg re

Full comment: avg res from fld trl 0103299001 1C Potato, tuber, w/peel

- babyfood 0.190000 1.000 0.100 avg re

Full comment: avg res from fld trl 0103300000 1C Potato, tuber, w/o peel 0.190000 1.000 0.100 avg re

Full comment: avg res from fld trl 010330 0001 1C Potato, tuber, w/o peel

- babyfood 0.190000 1.000 0.100 avg re

Full comment: avg res from fld trl 0600347000 6 Soybean, seed 0.770000 1.000 0.010 avg fi

Full comment: avg field trial residue (D211531) 0600349000 6 Soybean, soy milk 0.770000 1.000 0.010 avg fi

Full comment: avg field trial residue (D211531) 0600349001 6 Soybean, soy milk
- babyfood or in 0. 770000 1.000 0.010 avg fi

Full comment: avg field trial residue (D211531) 0600350000 6 Soybean, oil 0.770000 0.750 0.010 avg fl

Full comment: avg fld trl res and 0.75x proc factor (D211531) 060035000 1 6 Soybean, oil
- babyfood 0.770000 0.750 0.010 avg fl

Full comment: avg fld trl res and 0.75x proc factor (D211531) 0603348000 6C Soybean, flour 0.770000 1.000 0.010 avg fi

Full comment: avg field trial residue (D211531) 0603348001 6C Soybean, flour
- babyfood 0.770000 1.000 0.010 avg fi

Full comment: avg field trial residue (D211531) 1001106000 10A Citron 0.075000 1.000 1.000 1 001107000 10A Citrus hybrids 0.075000 1.000 1.000 1001108000 10A Citrus, oil 0.075000 1.000 1.000 1001240000 10A Orange 0.075000 1.000 1.000 1001241000 10A Orange, ju ice 0.075000 1.000 1.000 1001241001 10A Orange, juice
- babyfood 0.075000 1.000 1.000 1001242000 10A Orange, peel 0.075000 1.000 1.000 1001369000 10A Tangerine 0.075000 1.000 1.000 1001370000 10A Tangerine, juice 0.075000 1.000 1.000 1002197000 10B Kumquat 0.075000 1.000 1.000 1002199000 10B Lemon 0.075000 1.000 1.000 1002200000 10B Lemon, juice 0.075000 1.000 1.000 1002200001 10B Lemon, juice
- babyfood 0.075000 1.000 1.000 1002201000 10B Lemon, peel 0.075000 1.000 1.000 1002206000 10B Lime 0.075000 1.000 1.000 1002207000 10B Lime, juice 0.075000 1.000 1.000 1002207001 10B Lime, juice
- babyfood 0.075000 1.000 1.000 1003180000 10C Grapefruit 0.075000 1.000 1.000Glufosinate Ammonium Dietary Exposure Assessment DP#: 402741 PC Code: 128850

Page 18 of 27 1003181000 10C Grapefruit, juice 0.075000 1.000 1.000 1003307000 10C Pummelo 0.075000 1.000 1.000 1100007000 11 Apple, fruit with peel 0.025000 1.000 1.000 1100008000 11 Apple, peeled fruit 0.025000 1.000 1.000 1100008001 11 Apple, peeled fruit
- babyfood 0.025000 1.000 1.000 1100009000 11 Apple, dried 0.025000 8.000 1.000 1100009001 11 Apple, dried
- babyfood 0.025000 8.000 1.000 1100010000 11 Apple, juice 0.025000 1.000 1.000 proces

Full comment: processing factor reduced to 1 (PP#8F3607) 1100010001 11 Apple, jui ce - babyfood 0.025000 1.000 1.000 proces

Full comment: processing factor reduced to 1 (PP#8F3607) 1100011000 11 Apple, sauce 0.025000 1.000 1.000 1100011001 11 Apple, sauce
- babyfood 0. 025000 1.000 1.000 1100129000 11 Crabapple 0.025000 1.000 1.000 from a

Full comment: from apple SOP 2000.1 1100210000 11 Loquat 0.155000 1.000 1.000 1100266000 11 Pear 0.155000 1.000 1.000 D37262

Full comment: D372625 1100266001 11 Pear
- babyfood 0.155000 1.000 1.000 D37262

Full comment: D372625 1100267000 11 Pear, dried 0.155000 6.250 1.000 D37262

Full comment: D372625 1100268000 11 Pear, juice 0.155000 1.000 1.000 D37262

Full comment: D372625 1100268001 11 Pear, juice
- babyfood 0.155000 1.000 1.000 D37262

Full comment: D372625 1100310000 11 Quince 0.155000 1.000 1.000 1201090000 12A Cherry 0.156000 1.000 1.000 D37262

Full comment: D372625 1201090001 12A Cherry
- babyfood 0.156000 1.000 1.000 D37262

Full comment: D372625 1201091000 12A Cherry, juice 0.156000 1.500 1.000 D37262

Full comment: D372625 1201091001 12A Cherry, juice
- bab yfood 0.156000 1.500 1.000 D37262

Full comment: D372625 1202012000 12B Apricot 0.156000 1.000 1.000 1202012001 12B Apricot
- babyfood 0.156000 1.000 1.000 1202013000 12B Ap ricot, dried 0.156000 6.000 1.000 1202014000 12B Apricot, juice 0.156000 1.000 1.000 1202014001 12B Apricot, juice
- babyfood 0.156000 1.000 1.000 1202230000 12B Nectarine 0.075000 1.000 1.000 1202260000 12B Peach 0.075000 1.000 1.000 1202260001 12B Peach
- babyfood 0.075000 1.000 1.000 1202261000 12B Peach, dried 0.075000 7.000 1.000 1202261001 12B Peach, dried
- babyfood 0.075000 7.000 1.000 1202262000 12B Peach, juice 0.075000 1.000 1.000 1202262001 12B Peach, juice
- babyfood 0.075000 1.000 1.000 1203285000 12C Plum 0.153000 1.000 1.000 D37262

Full comment: D372625 1203285001 12C Plum
- babyfood 0.153000 1.000 1.000 D37262

Full comment: D372625 1203286000 12C Plum, prune, fresh 0.153000 1.000 1.000 D37262

Full comment: D372625 1203286001 12C Plum, prune, fresh
- babyfood 0.153000 1.000 1.000 D37262

Full comment: D372625 1203287000 12C Plum, prune, dried 0.153000 1.800 1.000 D37262

Full comment: D372625 1203287001 12C Plum, prune, dried
- babyfood 0.153000 1.800 1.000 D37262

Full comment: D372625 1203288000 12C Plum, prune, juice 0.153000 1.400 1.000 D37262

Full comment: D372625 1203288001 12C Plum, prune, juice
- babyfood 0.153000 1.400 1.000 D37262

Full comment: D372625 1302057000 13B Blueberry 0.055000 1.000 0.050 1302057001 13B Blueberry
- b abyfood 0.055000 1.000 0.050 1302136000 13B Currant 0.055000 1.000 1.000 1302137000 13B Currant, dried 0.055000 1.000 1.000 1302149000 13B Elderberry 0 .055000 1.000 1.000 1302174000 13B Gooseberry 0.055000 1.000 1.000 1302191000 13B Huckleberry 0.055000 1.000 1.000 1304175000 13D Grape 0.025000 1.000 0.150Glufosinate Ammonium Dietary Exposure Assessment DP#: 402741 PC Code: 128850

Page 19 of 27 1304176000 13D Grape, juice 0.025000 1.000 0.150 proces

Full comment: processing factor reduced to 1 (PP#843607) 1304176001 13D Grape, juice
- babyfood 0.025000 1.000 0.150 proces

Full comm ent: processing factor reduced to 1 (PP#843607) 1304179000 13D Grape, wine and sherry 0.025000 1.000 0.150 1400003000 14 Almond 0.050000 1.000 0.150 1400003001 14 Almond
- babyfood 0.0 50000 1.000 0.150 1400004000 14 Almond, oil 0.050000 1.000 0.150 1400004001 14 Almond, oil
- babyfood 0.050000 1.000 0.150 1400059000 14 Brazil nut 0.050000 1.000 1.000 14 00068000 14 Butternut 0.050000 1.000 1.000 1400081000 14 Cashew 0.050000 1.000 1.000 1400092000 14 Chestnut 0.050000 1.000 1.000 1400155000 14 Hazelnut 0.050000 1.000 0.100 1400156000 14 Hazelnut, oil 0.050000 1.000 0.100 1400185000 14 Hickory nut 0.050000 1.000 1.000 1400213000 14 Macadamia nut 0.050000 1.000 1.000 1400269000 14 Pecan 0.050000 1.000 0.010 1400282000 14 Pistachio 0.050000 1.000 0.200 1400391000 14 Walnut 0.050000 1.000 0.100 1500120000 15 Corn, field, flour 0.050000 1.000 0.050 avg re

Full comment: avg res 47542612 1500120001 15 Corn, field, flour
- babyfood 0.050000 1.000 0.050 av g re

Full comment: avg res 47542612 1500121000 15 Corn, field, meal 0.050000 1.000 0.050 avg re

Full comment: avg res 47542612 1500121001 15 Corn, field, meal
- babyfood 0.050000 1.000 0.050 avg re

Full comment: avg res 47542612 1500122000 15 Corn, field, bran 0.050000 1.000 0.050 avg re

Full comment: avg res 47542612 1500123000 15 Corn, field, starch 0.050000 1.000 0.050 avg re

Full comment: avg res 47542612 1500123001 15 Corn, field, starch
- babyfood 0.050000 1.000 0.050 avg re

Full comment: avg res 47542612 1500124000 15 Corn, field, syrup 0.050000 1.500 0.050 avg re

Full comment: avg res 47542612 1500124001 15 Corn, field, syrup
- babyfood 0.050000 1.500 0.050 avg re

Full comment: avg res 47542612 1500125000 15 Corn, field, oil 0.050000 1.000 0.050 avg re

Full comment: avg res 47542612 1500125001 15 Corn, field, oil
- babyfood 0.050000 1.000 0.050 avg re

Full comment: avg res 47542612 1500127000 15 Corn, sweet 0.110000 1.000 1.000 mean r

Full comment: mean res D372625 1500127001 15 Corn, sweet
- babyfood 0.110000 1.000 1.000 mean r

Full comment: mean res D372625 1500323000 15 Rice, white 0.200000 1.300 0.010 avg re

Full comment: avg res from fld trl and proc fact (D27110) 1500323001 15 Rice, white
- babyfood 0.200000 1.300 0.010 avg re

Full comment: avg res from fld trl and proc fact (D27110) 1500324000 15 Rice, brown 0.200000 1.300 0.010 avg re

Full comment: avg res from fld trl and proc fact (D27110) 1500324001 15 Rice, brown
- babyfood 0.200000 1.300 0.010 avg re

Full comment: avg res from fld trl and proc f act (D27110) 1500325000 15 Rice, flour 0.200000 1.300 0.010 avg re

Full comment: avg res from fld trl and proc fact (D27110) 1500325001 15 Rice, flour
- babyfood 0.200000 1.300 0.010 avg re

Full comment: avg res from fld trl and proc fact (D27110) 1500326000 15 Rice, bran 0.200000 0.900 0.010 avg re

Full comment: avg res from fld trl and proc fact (D27110) 1500326001 15 Rice, bran
- babyfood 0.200000 0.900 0.010 avg re

Full comment: avg res from fld trl and proc fact (D27110) 1500381000 15 Triticale, flour 0.200000 1.000 1.000 1500381001 15 Triticale, flour
- babyfood 0.200000 1.00 0 1.000 2001319000 20A Rapeseed, oil 0.200000 1.000 0.250 2001319001 20A Rapeseed, oil
- babyfood 0.200000 1.000 0.250 2003128000 20C Cottonseed, oil 1.120000 0.010 0.050 avg re

Full comment: avg res from fld trl & proc fact (D271110) 2003128001 20C Cottonseed, oil
- babyfood 1.120000 0.010 0.050 avg re

Full comment: avg res from fld trl & proc fact (D271110) 3100044000 31 Beef, meat 0.005900 1.000 1.000 AR RBDGlufosinate Ammonium Dietary Exposure Assessment DP#: 402741 PC Code: 128850

Page 20 of 27 Full comment: AR RBD Jun 2008 3100044001 31 Beef, meat
- babyfood 0.005900 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3100045000 31 Beef, meat, dried 0.005900 1.920 1.000 AR RBD

Full comment: AR RBD Jun 2008 3100046000 31 Beef, meat byproducts 0.960000 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 310004 6001 31 Beef, meat byproducts
- babyfood 0.960000 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3100047000 31 Beef, fat 0.065000 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3100047001 3 1 Beef, fat
- babyfood 0.065000 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3100048000 31 Beef, kidney 0.300000 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3100049000 31 Be ef, liver 0.960000 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3100049001 31 Beef, liver
- babyfood 0.960000 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3200169000 32 Goat, me at 0.005900 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3200170000 32 Goat, meat byproducts 0.960000 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3200171000 32 Goat, fat 0.065000 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3200172000 32 Goat, kidney 0.300000 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3200173000 32 Goat, liver 0.960000 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3300189000 33 Horse, meat 0.005900 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3400290000 34 Pork, meat 0.000590 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3400290001 34 Pork, meat
- babyfood 0.000590 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 340029 1000 34 Pork, skin 0.096000 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3400292000 34 Pork, meat byproducts 0.096000 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3400292001 3 4 Pork, meat byproducts
- babyfood 0.096000 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3400293000 34 Pork, fat 0.006500 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3400293001 34 Po rk, fat
- babyfood 0.006500 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3400294000 34 Pork, kidney 0.030000 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3400295000 34 Pork, li ver 0.096000 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3500339000 35 Sheep, meat 0.005900 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3500339001 35 Sheep, meat
- ba byfood 0.005900 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3500340000 35 Sheep, meat byproducts 0.960000 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3500341000 35 Sheep, fat 0.065000 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3500341001 35 Sheep, fat
- babyfood 0.065000 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3500342000 35 Sheep, kidney 0.300000 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3500343000 35 Sheep, liver 0.960000 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 360022 2000 36 Milk, fat 0.006800 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3600222001 36 Milk, fat
- baby food/infant formu 0.006800 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3600223000 3 6 Milk, nonfat solids 0.006800 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3600223001 36 Milk, nonfat solids
- baby food/in 0.006800 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008Glufosinate Ammonium Dietary Exposure Assessment DP#: 402741 PC Code: 128850

Page 21 of 27 3600224000 36 Mi lk, water 0.006800 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3600224001 36 Milk, water
- babyfood/infant form 0.006800 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3600225001 36 Milk, su gar (lactose)
- baby food/ 0.006800 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3800221000 38 Meat, game 0.005900 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 3900312000 39 Rabbit, meat 0.005900 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 4000093000 40 Chicken, meat 0.007100 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 4000093001 40 Chicken, meat
- babyfo od 0.007100 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 4000094000 40 Chicken, liver 0.014000 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 4000095000 40 Chicken, meat byproducts 0.046000 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 4000095001 40 Chicken, meat byproducts
- babyfoo 0.046000 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 4000096000 40 Chicken, fat 0.007100 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 4000096001 40 Chicken, fat
- babyfood 0.007100 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 400009 7000 40 Chicken, skin 0.007100 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 4000097001 40 Chicken, skin
- babyfood 0.007100 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 5000382000 5 0 Turkey, meat 0.007100 1.000 1.000 AR RDB

Full comment: AR RDB June 2008 5000382001 50 Turkey, meat
- babyfood 0.007100 1.000 1.000 AR RDB

Full comment: AR RDB June 2008 5000383000 50 Turkey, liver 0.014000 1.000 1.000 AR RDB

Full comment: AR RDB June 2008 5000383001 50 Turkey, liver
- babyfood 0.014000 1.000 1.000 AR RDB

Full comment: AR RDB June 2008 5000384000 50 Turk ey, meat byproducts 0.046000 1.000 1.000 AR RDB

Full comment: AR RDB June 2008 5000384001 50 Turkey, meat byproducts
- babyfood 0.046000 1.000 1.000 AR RDB

Full comment: AR RDB June 2008 5000385000 50 Turkey, fat 0.007100 1.000 1.000 AR RDB

Full comment: AR RDB June 2008 5000385001 50 Turkey, fat
- babyfood 0.007100 1.000 1.000 AR RDB

Full comment: AR RDB June 2008 5000386000 50 Turkey, skin 0.007100 1.000 1.000 AR RDB

Full comment: AR RDB June 2008 5000386001 50 Turkey, skin
- babyfood 0.007100 1.000 1.000 AR RDB

Full comment: AR RDB June 2008 6000301000 60 Poultry, other, meat 0.007100 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 6000302000 60 Poultry, other, liver 0.014000 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 600030 3000 60 Poultry, other, meat byproducts 0.046000 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 6000304000 60 Poultry, other, fat 0.007100 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 6000305000 6 0 Poultry, other, skin 0.007100 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 7000145000 70 Egg, whole 0.007100 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 7000145001 70 Eg g, whole
- babyfood 0.007100 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 7000146000 70 Egg, white 0.007100 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 7000146001 70 Egg, whi te (solids)
- babyfood 0.007100 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 7000147000 70 Egg, yolk 0.007100 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 7000147001 70 Egg, yolk
- baby food 0.007100 1.000 1.000 AR RBD

Full comment: AR RBD Jun 2008 8601000000 86A Water, direct, all sources 0.095000 1.000 1.000 EFED EGlufosinate Ammonium Dietary Exposure Assessment DP#: 402741 PC Code: 128850

Page 22 of 27 Full comment: EFED EDWC 8602000000 86B Water, indirect, all sour ces 0.095000 1.000 1.000 EFED E

Full comment: EFED EDWC 9500023000 O Banana 0.080000 1.000 1.000 avg fi

Full comment: avg field trial residue (D172878) 9500023001 O Banana
- babyfood 0.080000 1.000 1.000 avg fi

Full comment: avg field trial residue (D172878) 9500024000 O Banana, dried 0.080000 3.900 1.000 avg fi

Full comment: avg field trial residue (D172878) 9 500024001 O Banana, dried
- babyfood 0.080000 3.900 1.000 avg fi

Full comment: avg field trial residue (D172878) 9500177000 O Grape, leaves 0.025000 1.000 0.150 9500178000 O Grape, raisin 0.025000 1.000 0.150 proces

Full comment: processing factor reduced to 1 (PP#8F3607) 9500235000 O Olive 0.075000 1.000 1.000 9500236000 O Olive, oil 0.075000 0. 600 1.000 9500283000 O Plantain 0.080000 1.000 1.000 9500284000 O Plantain, dried 0.080000 3.900 1.000Glufosinate Ammonium Dietary Exposure Assessment DP#: 402741 PC Code: 128850

Page 23 of 27 

### Attachment 4 **: Chronic Results File at**  **an EDWC of**  **95 ppb.** 

Ver. 3.10 DEEM - FCID Chronic analysis for GLUFOSINATE AMMONIUM NHANES 2003
- 2008 2
- day Residue file name: C: \ Documents and Settings \ wdonovan \ My Documents \ CalendexWWEIAFCID \ 128850c.R 08 Adjustment factor #2 used. Analysis Date 06
- 19
- 2012/09:32:00 Residue file dated: 06

- 19
- 2012/08:05:17 Reference dose (RfD, Chronic) = .006 mg/kg bw/day COMMENT 1: 95 ppb EDWC, 2012 SLUA

=========== ==================================================================== Total exposure by population subgroup

------------------------------------------------------------------------------- Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- ---------------- Total US Population 0.002324 38.7% Hispanic 0.002343 39.0% Non - Hisp
- White 0.002353 39.2% Non - Hisp
- Black 0.001998 33.3% Non - Hisp
- Other 0.002668 44.5% Nursing Infants 0.002273 37.9% Non - Nursing Infants 0.007501 125.0% Female 13+ PREG 0.002198 36.6% Children 1
- 6 0.003708 61.8% Children 7
- 12 0.002130 35.5% Male 13
- 19 0.001645 27.4% Female 13
- 19/NP 0.001767 29.4% Male 20+ 0.002084 34.7% Female 20+/NP 0.002310 38.5% Seniors 55+ 0.002166 36.1% All Infants 0.0058 87 98.1% Female 13
- 50 0.002198 36.6% Children 1
- 2 0.004387 73.1% Children 3
- 5 0.003447 57.4% Children 6
- 12 0.002261 37.7% Youth 13
- 19 0.001706 28.4% Adults 20
- 49 0.002203 36.7% Adults 50
- 99 0.002202 36.7% Female 13
- 49 0.002195 36.6%

-------------------------------------------------------------------------------Glufosinate Ammonium Dietary Exposure Assessment DP#: 402741 PC Code: 128850

Page 24 of 27 

### Attachment 5 **. Dietary Burden and Livestock**  **AR Calculations for Glufosinate Ammonium.**
**Table 6 : Livestock Anticipated Dietary Burden Calculation for Glufosinate Ammonium (Chronic Scenario)** 
**commodity Average**  **residue (ppm)**  **% dry**

**matter % diet**  **dietary burden (ppm)**

**Beef cattle Dairy cattle**  **Poultry Sw**  **ine Beef cattle**  **Dairy cattle Poultry**  **Sw ine**  aspirated grain fractions CC 9.2 a 85 5 -- -- -- 0.54

-- -- -- field corn grain CC 0.05 b 88 45 1 5 55 65 0.026 0.0085 0.028 0.033 field corn forage R 1.8 c 40 10 45 -- -- 0.45 2.03 -- -- soybea n hulls R 2.0 c 90

-- -- -- -- -- -- -- -- soybean meal PC 0.77 c 92

-- -- 5
-- -- -- 0.039

-- soybea n seed PC 0.77 b 89 5
-- 20 15 0.043

-- 0.154 0.12 sugar beet m olasses CC 1.6 d 75 10 10 -- -- 0.21 0.21 -- -- undeli nted cottonseed PC 1.1 e 88

-- 10 -- -- -- 0.125 -- -- cotton gin byproducts R 3.8 e 90 5
-- -- -- 0.21

-- -- -- rice g rain CC 0.2 e 88 20 20 20 20 0.045 0.045 0.04 0.04 dietar y burden 1.52 2.42 0.26 0.19

a D22738 6, M.I. Rodriguez, 26

- AUG

- 1996. Max CF = 12x. AR = CF X Avg soybean residue = 12 X 0.77 = 9.24 ppm. b D211531, M.I. Rodriguez, 07

- MAR

- 1996. c D219069 & D211531, M.I. Rodriguez, 07

- MAR

- 1996. Range of F. corn forage residues: 0.15

– 3.6 ppm. Avg = 1⁄2 X 3.6 = 1.8. ppm. Soybean hulls: 2.66 (CF) X 0.77 = 2.0 ppm; soybean meal: 1.0 (CF) X 0.77 = 0.77 ppm. d D257682, T. Bloem, 09

- JUL
- 1999. Molasses CF = 6.8X. 6.8 x 0.24 ppm (Avg sugar beet residue) = 1.6 ppm. e D271110, T. Bloem, 20

- JUN
- 2002 [45089303.der.w pd] cottonseed avg = 1.12 ppm; cotton gin byproduct avg = 3.76 ppm

. [45204406.der.w pd] rice grain avg = 0.20 ppm.Glufosinate Ammonium Dietary Exposure Assessment DP#: 402741 PC Code: 128850

Page 25 of 27 **Table 7 : Results of a Ruminant Feeding St**  **udy; Livestock Fe d a Diet Spiked with**  **Glufosinate Ammonium:HOE 061517 (15:85) MRID 43766921 (D211531, M. Rodriguez, 7**  **- Mar**  **- 1996)** 

**commodity max**  **im um**  **combined 039866, 099730, and 061517 residue at the three dosing levels (ppm)**  **combined 039866, 099730, and 061517 residue used in the chronic dietary exposure assessment**  **9.1 ppm beef** 

**– 5.9**  **x dai**  **ry –**  **3.8 x**  **27.3 ppm beef**  **-- 18x**  **dairy**

**– 11**  **x 91.1 ppm**  **beef**

**– 5**  **9 x**  **dairy**

**– 3**  **8x** milk <0.04 <0.048 0.259 Residue = 0.259/38 = 0.0068 ppm cow kidney <0.20 <0.20 0.28 residues in this study were generally <LOQ while residues in the 3:1 glufosinate ammonium:061517 feeding study (see below) were generally >LOQ; therefore, the 3:1 feeding study was used for calculation of residues in kidney, liver, meat, and fat (see below ) fat <0.10 <0.10 <0.10 liver <0.20 <0.20 0.39 muscle <0.10 <0.10 <0.10

**Table 8 : Results of a Rumin**  **ant Feeding Study; Livestock Fe d a Diet Spiked with Glufosinate Ammonium:HOE 061517 (3:1)**  **PP#8F3607, J. Garbus, 8 -**  **Aug -**  **1990**

**commodity max**  **im um**  **combined 039866, 099730, and 061517 residue at the three dosing levels (ppm)**  **combined 039866, 099730, and 061517 residue used in the chronic dietary exposure assessment**  **4 ppm beef** 

**– 2.6x**  **dairy**

**– 1.7**  **x 12 ppm**  **beef -**  **7.8 x**  **dairy**

**– 5.0**  **x 40 ppm**  **beef**

**– 26x**  **dairy**

**– 17**  **x** milk <0.07 <0.07 <0.07 residues in this study were <LOQ while residues in the 15:85 glufosinate ammonium:061517 feeding study (see above) were > LOQ; therefore, the 15:85 feeding study was used for calculation of residues in milk (see above) kidney <0.51 <2.1 7.5 Residue = 0.51/1.7 = 0.30 ppm cow; 0. 03 ppm swine muscle <0.10 <0.10 <0.10 Residue = 0.10/17 = 0.0059 ppm cow; 0.00059 ppm swine fat <0.11 <0.13 <0.21 Residue = 0.11/1.7 = 0.065 ppm cow; 0.0065 ppm swine liver 1.63 <4.3 <10.8 Residue = 1.63/1.7 = 0.96 ppm cow; 0.096 ppm swine 1 R esidue in cattle  10x to calculate residue in swine (swine diet approx. 10x less than that of cattle)Glufosinate Ammonium Dietary Exposure Assessment DP#: 402741 PC Code: 128850

Page 26 of 27 

### Table 9. Results of Glufosinate Ammonium Feeding Studies in Hens **.**

**matrix ppm (glufosinate free acid equivalents) in Laying Hens dosed with**  **15:85 glufosinate ammonium:N -**  **acetyl -**  **glufosinate**

**HOE 039866/ HOE 099730**  **2 +**  **HOE 061517 HOE 039866/** 

**HOE 099730 2**  **+ HOE 061517**  **HOE 039866/ HOE 099730**  **2 +**  **HOE 061517 Chronic anticipated residue at 1x RDB**  **1** 0.36 ppm [ 1.4x MTDB] 1.08 ppm [4.2x

MTDB] 3.6 ppm [14x MTDB]
liver <0.20 <0.20 <0.20 <0.014 skin <0.10 <0.10 < 0.10 <0.0071 muscle <0.10 <0.10 <0.10 <0.0071 fat <0.10 <0.10 <0.10 <0.0071
egg <0.10 <0.10 <0.10 <0.0071 3:1 glufosinate ammonium:HOE 061517 4.5 ppm [ 17x MTDB] 13.5 ppm [ 5 2x

MTDB] 45 ppm [ 170x MTDB]
liver <0.20 <0.20 <0.20 See above kidney <0.74 2.07 7.85 0.046 muscle <0.10 <0.10 <0.10 See above fat <0.10 <0.10 <0.10 See above
egg <0.10 <0.10 <0.12 See above

1 If residues were <LOQ at all three dosing levels then an anticipated residue (AR) was calculated using the results from the highest dose level. If residues were >LOQ at all three dosing levels, then the AR was calculated using the results from the dosing level closest to the RDB. 2 HOE 099730 w as not reported in the 3:1 glufosinate ammonium:HOE 06151 7 feeding study, analytical method w ould not have distinguished betw een HOE 039866 and HOE 099730 or the D and L enantiomers of these compoundsGlufosinate Ammonium Dietary Exposure Assessment DP#: 402741 PC Code: 128850

Page 27 of 27 

### Attac **hment 6 . Glufosinate**  **Ammonium SLUA dated 19 -**  **MAR -**  **2012 March 19, 2012**  

### Screening Level Estimates of Agricultural Uses of **Glufosinate (**  **128850 )**  **Sorted Alphabetically Percent Crop Ttd.**  **Crop Lbs. A.I.**  **Avg. PCT**  **Max. PCT**  **1** Almonds 200,000 15 40 **2** Apples 4,000 <1 <2.5 **3** Blueberries 10,000 5 15 **4** Canola 100,000 25 35 **5** Cherries+ 1,000 <1 <2.5 **6** Corn 1,300,000 5 10 **7** Cotton 200,000 5 10 **8** Fallow <500 <1 <2.5 **9** Figs ** <500 NC NC **10** Grapes 200,000 15 30 **11** Hazelnuts 6,000 10 25 **12** Peaches+ 2,000 <2.5 10 **13** Peanuts+ 1,000 <1 <2.5 **14** Pecans 1,000 <1 <2.5 **15** Pistachios 50,000 20 45 **16** Plums/Prunes+ 2,000 <2.5 10 **17** Pom egranates ** <500 NC NC **18** Potatoes 30,000 10 20 **19** Rice 5,000 <1 <2.5 **20** Soy beans 100,000 <1 <2.5 **21** Sweet Corn <500 <1 <2.5 **22** Walnuts 30,000 10 20 All numbers rounded. <500 : indicates less than 500 pounds of active ingredient. <2.5 : indicates less than 2.5 percent of crop is treated. <1 : indicates less than 1 percent of crop is treated. ** : California data only. No information available about use of this chemical on this crop in other states. NC: Not calculated + Crops not known to be listed on active end use product registrations or as Section 18 emergency exemptions when this report was run SLUA data sources include: USDA

- NASS (United States Department of Agriculture's National Agricultural Statistics Service) Private Pesticide Market Research California DPR (Department of Pesticide Regulation) These results reflect amalgamated data developed by the Agency and are releasable to the public.