Exhibit 4.3


 


SORRENTO THERAPEUTICS, INC.


 


REGISTRATION RIGHTS AGREEMENT


 


This
Registration Rights Agreement (this “Agreement”) is made as of December 21, 2017, by and
among Sorrento Therapeutics, Inc., a Delaware corporation (the “Company”), and the purchasers identified
on Schedule A hereto (each, a “Purchaser” and collectively,
the “Purchasers”) and such other Persons, if any, from time to time, that become a party hereto as holders
of Registrable Securities (as defined below). Unless otherwise defined herein, capitalized terms used in this Agreement have the
meanings ascribed to them in that certain Securities Purchase Agreement dated as of December 11, 2017 by and among the Company
and the Purchasers (as may be amended or restated from time to time, the “Purchase Agreement”).


 


RECITALS


 


Whereas,
pursuant to the Purchase Agreement, concurrently with the execution of this Agreement, at the Closing, each Purchaser will purchase
from the Company, and the Company will issue and sell to each Purchaser, (i) a convertible promissory note in the form attached
as Exhibit A to the Purchase Agreement,
in the aggregate principal amount set forth opposite such Purchaser’s name on Schedule
A hereto (each, a “Note” and collectively, the “Notes”), and (ii)
a warrant to purchase such number of shares of Common Stock as is set forth opposite such Purchaser’s name on Schedule
A hereto (each, a “Warrant” and collectively, the “Warrants”);


 


Whereas,
the Notes will be convertible into shares of Common Stock from time to time, and the Warrants will be exercisable into shares of
Common Stock from time to time on the date that is 181 days after the Closing Date, in each case in accordance with the terms thereof;
and


 


Whereas,
in connection with the execution and delivery of the Purchase Agreement and the consummation of the transactions contemplated thereby,
the Company has agreed to grant the Holders (as defined below) certain registration rights as set forth below.


 


Now,
Therefore, in consideration of the mutual promises and covenants herein contained, and other consideration, the receipt
and adequacy of which is hereby acknowledged, the parties hereto agree as follows:


 


Article
I.

Definitions


 


1.1          Definitions.
As used in this Agreement, the following terms shall have the meanings set forth below:


 


(a)          “Additional
Shares” means any shares of Common Stock issued to the Purchasers pursuant to a stock split, stock dividend or other
distribution with respect to, or in exchange or in replacement of, the Shares.


 




     


     


    

 


(b)          “Affiliate”
means, with respect to any specified Person, any other Person who or which, directly or indirectly, controls, is controlled by,
or is under common control with such specified Person, including, without limitation, any general partner, limited partner, member,
officer, director or manager of such Person and any venture capital or private equity fund now or hereafter existing that is controlled
by one or more general partners or managing members of, or shares the same management company with, such Person. For purposes of
this definition, the terms “controls,” “controlled by,” or “under
common control with” means the possession, direct or indirect, of power to direct or cause the direction of management
or policies (whether through ownership of voting securities, by contract or otherwise).


 


(c)          “Business
Day” means a weekday on which banks are open for general banking business in San Diego, California.


 


(d)         “Common Stock” means shares of the common stock of the Company, par value $0.0001 per share.


 


(e)          “Entity”
means any corporation (including any non profit corporation), general partnership, limited partnership, limited liability partnership,
joint venture, estate, trust, company (including any limited liability company or joint stock company), firm or other enterprise,
association, organization or entity.


 


(f)          “Exchange
Act” means the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder,
as the same may be amended from time to time.


 


(g)         “Governmental
Body” means any domestic or foreign multinational, federal, state, provincial, municipal or local government (or
any political subdivision thereof) or any domestic or foreign governmental, regulatory or administrative authority or any department,
commission, board, agency, court, tribunal, judicial body or instrumentality thereof, or any other body exercising, or entitled
to exercise, any administrative, executive, judicial, legislative, police, regulatory or taxing authority or power of any nature
(including any arbitral body).


 


(h)          “Holder”
(collectively, “Holders”) means any Purchaser and any transferee permitted under Section 3.1, in each
case, to the extent holding Registrable Securities.


 


(i)           “Person”
means any individual, Entity, trust, Governmental Body or other organization.


 


(j)           “register,”
“registered” and “registration” refer to a registration effected by filing
with the SEC a registration statement in compliance with the Securities Act, and the declaration or ordering by the SEC of the
effectiveness of such registration statement.


 


(k)          “Registrable
Securities” means (i) the Shares, and (ii) any Additional Shares; provided, however, that Shares or
Additional Shares shall cease to be treated as Registrable Securities on the earliest to occur of, (a) the date such security has
been disposed of pursuant to an effective registration statement, (b) the date on which such security is sold pursuant to Rule
144, (c) the date on which such security ceases to be outstanding, or (d) the date on which the Holder thereof, together with its
Affiliates, is able to dispose of all of its Registrable Securities without restriction or limitation pursuant to Rule 144 and
without the requirement to be in compliance with Rule 144 (or any successor rule).


 




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(l)           “Registration
Expenses” means any and all expenses incident to the performance
of or compliance with this Agreement, including without limitation: (i) all registration and filing fees; (ii) all fees and expenses
associated with a required listing of the Registrable Securities on any securities exchange; (iii) fees and expenses with respect
to filings required to be made with an exchange or any securities industry self-regulatory body; (iv) fees and expenses of compliance
with securities or “blue sky” laws (including reasonable fees and disbursements of counsel for the underwriters or
holders of securities in connection with blue sky qualifications of the securities and determination of their eligibility for investment
under the laws of such jurisdictions); (v) printing, messenger, telephone and delivery expenses of the Company; (vi) fees and disbursements
of counsel for the Company and customary fees and expenses for independent certified public accountants retained by the Company
(including the expenses of any comfort letters, or costs associated with the delivery by independent certified public accountants
of a comfort letter or comfort letters, if such comfort letter or comfort letters is required by the managing underwriter); (vii)
securities acts liability insurance, if the Company so desires; (viii) all internal expenses of the Company (including, without
limitation, all salaries and expenses of its officers and employees performing legal or accounting duties); (ix) the expense of
any annual audit; and (x) the fees and expenses of any Person, including special experts, retained by the Company; provided,
however that “Registration Expenses” shall not include underwriting fees, discounts or commissions
attributable to the sale of the Registrable Securities or any legal fees and expenses of counsel to the Holders.


 


(m)         “Rule
144” means Rule 144 under the Securities Act.


 


(n)          “SEC”
means the Securities and Exchange Commission.


 


(o)          “Securities
Act” means the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder, as the same
may be amended from time to time.


 


(p)          “Shares”
means any and all shares of Common Stock issuable upon conversion of the Notes and exercise of the Warrants.


 


Article
II.

Registration Rights


 


2.1          Resale
Registration Statements. Within 45 days following the Closing
Date, the Company shall (a) file with the SEC, or (b) have filed with
the SEC, a resale registration statement (together with any New Registration Statement (as defined below), the “Resale
Registration Statement”) pursuant to Rule 415 under the Securities Act pursuant to which all of the Registrable Securities
shall be included (on the initial filing or by supplement or amendment thereto) to enable the public resale on a delayed or continuous
basis of the Registrable Securities by the Holders. The Company shall file the Resale Registration Statement on such form as the
Company may then utilize under the rules of the SEC and use its best efforts to have the Resale Registration Statement declared
effective under the Securities Act as soon as practicable, but in no event more than the earlier of: (A) 120 days following
the Closing Date, and (B) five trading days after the date the
Company receives written notification from the SEC that the Resale Registration Statement will not be reviewed. The Company agrees
to use its best efforts to maintain the effectiveness of the Resale
Registration Statement, including by filing any necessary post-effective amendments and prospectus supplements, or, alternatively,
by filing one or more new registration statements (each, a “New Registration Statement”) relating to
the Registrable Securities as required by Rule 415 under the Securities Act, continuously until the date that is the earlier of
(i) four years following the date of effectiveness of the Resale Registration Statement, or (ii) the date on which the Holders
no longer hold any Registrable Securities covered by the Resale Registration Statement.


 




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2.2          Provisions
Relating to Registration.


 


(a)          Notwithstanding
any other provisions of this Agreement to the contrary, the Company shall cause (i) the Resale Registration Statement (as of the
effective date of the Resale Registration Statement), any amendment thereof (as of the effective date thereof) or supplement thereto
(as of its date), (A) to comply in all material respects with the applicable requirements of the Securities Act and the rules and
regulations of the SEC, and (B) not to contain any untrue statement of a material fact or omit to state a material fact required
to be stated therein or necessary in order to make the statements therein not misleading, and (ii) any related prospectus, preliminary
prospectus and any amendment thereof or supplement thereto, as of its date, (A) to comply in all material respects with the applicable
requirements of the Securities Act and the rules and regulations of the SEC, and (B) not to contain any untrue statement of a material
fact or omit to state a material fact required to be stated therein or necessary in order to make the statements therein, in the
light of the circumstances under which they were made, not misleading; provided, however, the Company shall have
no such obligations or liabilities with respect to any written information pertaining to a Holder and furnished to the Company
by or on behalf of such Holder specifically for inclusion therein.


 


(b)          The
Company shall notify the Holders: (i) when the Resale Registration Statement or any amendment thereto has been filed with the SEC
and when the Resale Registration Statement or any post-effective amendment thereto has become effective; (ii) of any request by
the SEC for amendments or supplements to the Resale Registration Statement or the prospectus included therein or for additional
information; (iii) of the issuance by the SEC of any stop order suspending the effectiveness of the Resale Registration Statement
or the initiation of any proceedings for that purpose and of any other action, event or failure to act that would cause the Resale
Registration Statement not to remain effective; and (iv) of the receipt by the Company of any notification with respect to the
suspension of the qualification or exemption from qualification of any Registrable Securities for sale in any jurisdiction or the
initiation of any proceeding for such purpose.


 


(c)          As
promptly as practicable after becoming aware of such event, the Company shall notify the Holders of the happening of any event
(a “Suspension Event”), of which the Company has knowledge, as a result of which the prospectus included
in the Resale Registration Statement as then in effect, includes an untrue statement of a material fact or omission to state a
material fact required to be stated therein or necessary to make the statements therein not misleading, and use its best efforts
promptly to prepare a supplement or amendment to the Resale Registration Statement to correct such untrue statement or omission,
and deliver such number of copies of such supplement or amendment to the Holders as the Holders may reasonably request; provided,
however, that, for not more than 45 consecutive trading days (or a total of not more than 120 trading days in any 12 month
period), the Company may delay, to the extent permitted by and in a manner not in violation of applicable securities laws, the
disclosure of material non-public information concerning the Company (as well as prospectus or Resale Registration Statement updating),
the disclosure of which at the time is not, in the good faith opinion of the Company, in the best interests of the Company; provided,
further, that, if the Resale Registration Statement was not filed on Form S-3, such number of days shall not include the
15 calendar days following the filing of any Current Report on Form 8-K, Quarterly Report on Form 10-Q or Annual Report on Form
10-K, or other comparable form, for purposes of filing a post-effective amendment to the Resale Registration Statement.


 




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(d)          Upon
a Suspension Event, the Company shall give written notice (a “Suspension Notice”) to the Holders to suspend
sales of the affected Registrable Securities, and such notice shall state that such suspension shall continue only for so long
as the Suspension Event or its effect is continuing and the Company is pursuing with reasonable diligence the completion of the
matter giving rise to the Suspension Event or otherwise taking all reasonable steps to terminate suspension of the effectiveness
or use of the Resale Registration Statement. In no event shall the Company, without the prior written consent of the Holders, disclose
to the Holders any of the facts or circumstances giving rise to the Suspension Event. The Holders shall not effect any sales of
the Registrable Securities pursuant to the Resale Registration Statement (or such filings), at any time after they have received
a Suspension Notice and prior to receipt of an End of Suspension Notice. The Holders may resume effecting sales of the Registrable
Securities under the Resale Registration Statement (or such filings), following further notice to such effect (an “End
of Suspension Notice”) from the Company. This End of Suspension Notice shall be given by the Company to the Holders
in the manner described above promptly following the conclusion of any Suspension Event and its effect. For the avoidance of doubt,
a Suspension Notice shall not affect or otherwise limit sales of affected Registrable Securities under Rule 144 or otherwise outside
of the Resale Registration Statement.


 


(e)          Notwithstanding
any provision herein to the contrary, if the Company gives a Suspension Notice pursuant to this Section 2.2 with respect to the
Resale Registration Statement, the Company shall extend the period during which the Resale Registration Statement shall be maintained
effective under this Agreement by the number of days during the period from the date of the giving of the Suspension Notice to
and including the date when the Holders shall have received the End of Suspension Notice and copies of the supplemented or amended
prospectus necessary to resume sales.


 


(f)          The
Company shall bear all Registration Expenses incurred by the Company in connection with the registration of the Registrable Securities
pursuant to this Agreement.


 


(g)          Notwithstanding
anything to the contrary contained in this Agreement, the Company shall not be required to include Registrable
Securities in the Resale Registration Statement unless the Holder owning the Registrable Securities to be registered on
the Resale Registration Statement, following reasonable advance written request by the Company, furnishes to the Company, at least
10 Business Days prior to the scheduled filing date of the Resale Registration Statement, an executed stockholder questionnaire
in the form attached hereto as Exhibit A.


 




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2.3          Indemnification.



 


(a)          In
the event of the offer and sale of the Registrable Securities held by the Holders
under the Securities Act, the Company agrees to indemnify and hold harmless each Holder and its directors, officers, employees,
Affiliates and agents and each Person who controls such Holder within the meaning of the Securities Act or the Exchange Act (collectively,
the “Holder Indemnified Parties”) from and against any
losses, claims, damages or liabilities, joint or several, or any actions in respect thereof to which each Holder
Indemnified Party may become subject under the Securities Act or the Exchange Act, insofar as such losses, claims, damages, liabilities
or actions arise out of or are based upon (i) any untrue statement or alleged untrue statement of a material fact contained
in the Resale Registration Statement or in any amendment thereof, in each case at the time such became effective under the Securities
Act, or in the preliminary prospectus or other information that is deemed, under Rule 159 promulgated under the Securities Act
to have been conveyed to purchasers of securities at the time of sale of such securities (“Disclosure Package”),
in the prospectus or in any amendment thereof or supplement thereto, or (ii) the omission or alleged omission to state therein
a material fact required to be stated therein or necessary to make the statements therein (in the case of a Disclosure Package
or any prospectus, in the light of the circumstances under which they were made) not misleading, and shall reimburse, as incurred,
the Holder Indemnified Parties for any legal or other expenses
reasonably incurred by them in connection with investigating or defending any such loss, claim, damage, liability or action in
respect thereof; provided, however, that the Company shall not be liable in any such case to the extent that such
loss, claim, damage or liability arises out of or is based upon any untrue statement or omission made in the Resale Registration
Statement, the Disclosure Package, any prospectus or in any amendment thereof or supplement thereto in reliance upon and in conformity
with written information pertaining to a Holder and furnished to
the Company by or on behalf of such Holder Indemnified Party specifically
for inclusion therein; provided further, however, that the Company shall not be liable in any such case to the extent that
such loss, claim, damage or liability arises out of or is based upon any untrue statement or alleged untrue statement or omission
or alleged omission made in the Disclosure Package, where (A) such statement or omission had been eliminated or remedied in
any subsequently filed amended prospectus or prospectus supplement (the Disclosure Package, together with such updated documents,
the “Updated Disclosure Package”), the filing of which such Holder had been notified in accordance with
the terms of this Agreement, (B) such Updated Disclosure Package was available at the time such Holder
sold Registrable Securities under the Resale Registration Statement, (C) such Updated Disclosure Package was not furnished
by such Holder to the Entity asserting the loss, liability, claim, damage or liability, or an underwriter involved in the distribution
of such Registrable Securities, at or prior to the time such furnishing is required by the Securities Act, and (D) the Updated
Disclosure Package would have cured the defect giving rise to such loss, liability, claim, damage or action; and provided further,
however, that this indemnity agreement will be in addition to any liability that the Company may otherwise have to such
Holder Indemnified Party. Such indemnity shall remain in full force and effect regardless of any investigation made by or on behalf
of any Holder Indemnified Parties and shall survive the transfer
of the Registrable Securities by any Holder.


 




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(b)          As
a condition to including any Registrable Securities to be offered by a Holder
in any registration statement filed pursuant to this Agreement, such Holder agrees to severally and not jointly indemnify and hold
harmless the Company, each of its directors, each of its officers who signs the Resale Registration Statement, as well as any officers,
employees, Affiliates and agents of the Company, and each Person, if any, who controls the Company within the meaning of the Securities
Act or the Exchange Act (a “Company Indemnified Party”) from and against any losses, claims, damages
or liabilities or any actions in respect thereof, to which a Company Indemnified Party may become subject under the Securities
Act or the Exchange Act, insofar as such losses, claims, damages, liabilities or actions arise out of or are based upon (i) any
untrue statement or alleged untrue statement of a material fact contained in the Resale Registration Statement or in any amendment
thereof, in each case at the time such became effective under the Securities Act, or in any Disclosure Package, prospectus or in
any amendment thereof or supplement thereto, or (ii) the omission or alleged omission to state therein a material fact required
to be stated therein or necessary to make the statements therein (in the case of the Disclosure Package or any prospectus, in the
light of the circumstances under which they were made) not misleading, but in each case only to the extent that the untrue statement
or omission or alleged untrue statement or omission was made in reliance upon and in conformity with written information pertaining
to such Holder and furnished to the Company by or on behalf of the such Holder specifically for inclusion therein; and, subject
to the limitation immediately preceding this clause, shall reimburse, as incurred, the Company Indemnified Parties for any legal
or other expenses reasonably incurred by them in connection with investigating or defending any loss, claim, damage, liability
or action in respect thereof. Such indemnity shall remain in full force and effect regardless of any investigation made by or on
behalf of such Holder, or any such director, officer, employees, Affiliates and agents and shall survive the transfer of such Registrable
Securities by such Holder, and such Holder shall reimburse the Company, and each such director, officer, employees, Affiliates
and agents for any legal or other expenses reasonably incurred by them in connection with investigating, defending, or settling
and such loss, claim, damage, liability, action, or proceeding; provided, however, that the indemnity amount contained in
this Section 2.3(b) shall in no event exceed the gross proceeds from the offering received by such Holder. Such indemnity shall
remain in full force and effect, regardless of any investigation made by or on behalf of the Company or any such director, officer,
employees, Affiliates and agents and shall survive the transfer by a Holder of such Registrable Securities.


 




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(c)          Promptly
after receipt by a Holder Indemnified Party or a Company Indemnified Party (each, an “Indemnified Party”)
of notice of the commencement of any action or proceeding (including a governmental investigation), such Indemnified Party will,
if a claim in respect thereof is to be made against the indemnifying party under this Section 2.3, notify the indemnifying party
of the commencement thereof; but the omission to so notify the indemnifying party will not relieve the indemnifying party from
liability under Sections 2.3(a) or 2.3(b)  unless and to the extent it did not otherwise learn of such action and the indemnifying
party has been materially prejudiced by such failure. In case any such action is brought against any Indemnified Party, and it
notifies the indemnifying party of the commencement thereof, the indemnifying party will be entitled to participate therein and,
to the extent that it may wish, jointly with any other indemnifying party similarly notified, to assume the defense thereof, with
counsel reasonably satisfactory to such Indemnified Party (who shall not, except with the consent of the Indemnified Party, be
counsel to the indemnifying party), and after notice from the indemnifying party to such Indemnified Party of its election so to
assume the defense thereof the indemnifying party will not be liable to such Indemnified Party under this Section 2.3 for any legal
or other expenses, other than reasonable costs of investigation, subsequently incurred by such Indemnified Party in connection
with the defense thereof; provided, however, if such Indemnified Party shall have been advised by counsel that there
are one or more defenses available to it that are in conflict with those available to the indemnifying party (in which case the
indemnifying party shall not have the right to direct the defense of such action on behalf of the Indemnified Party), the reasonable
fees and expenses of such Indemnified Party’s counsel shall be borne by the indemnifying party. In no event shall the indemnifying
party be liable for the fees and expenses of more than one counsel (together with appropriate local counsel) at any time for any
Indemnified Party in connection with any one action or separate but substantially similar or related actions arising in the same
jurisdiction out of the same general allegations or circumstances. No indemnifying party shall, without the prior written consent
of the Indemnified Party (not to be unreasonably withheld or delayed), effect any settlement of any pending or threatened action
in respect of which any Indemnified Party is or could have been a party and indemnity could have been sought hereunder by such
Indemnified Party unless such settlement (i) includes an unconditional release of such Indemnified Party from all liability
on any claims that are the subject matter of such action and (ii) does not include a statement as to or an admission of fault,
culpability or a failure to act by or on behalf of any Indemnified Party. If the indemnification provided for in this Section 2.3
is unavailable or insufficient to hold harmless an Indemnified Party under Sections 2.3(a) or 2.3(b), then each indemnifying party
shall contribute to the amount paid or payable by such Indemnified Party as a result of the losses, claims, damages or liabilities
(or actions in respect thereof) referred to in Sections 2.3(a) or 2.3(b) in such proportion as is appropriate to reflect the relative
fault of the indemnifying party or parties on the one hand and the Indemnified Party on the other in connection with the statements
or omissions that resulted in such losses, claims, damages or liabilities (or actions in respect thereof) as well as any other
relevant equitable considerations. The relative fault of the parties shall be determined by reference to, among other things, whether
the untrue or alleged untrue statement of a material fact or the omission or alleged omission to state a material fact relates
to information supplied by the Company on the one hand or a Holder or Holder Indemnified Party, as the case may be, on the other,
and the parties’ relative intent, knowledge, access to information and opportunity to correct or prevent such statement or
omission. The amount paid by an Indemnified Party as a result of the losses, claims, damages or liabilities referred to in the
first sentence of this Section 2.3 shall be deemed to include any legal or other expenses reasonably incurred by such Indemnified
Party in connection with investigating or defending any action or claim that is the subject of this Section 2.3(c). The parties
agree that it would not be just and equitable if contributions were determined by pro rata allocation (even if a Holder
was treated as one Entity for such purpose) or any other method of allocation that does not take account of the equitable considerations
referred to above. Notwithstanding any other provision of this Section 2.3(c), no Holder shall be required to contribute any amount
in excess of the amount by which the net proceeds received by such Holder from the sale of the Registrable Securities pursuant
to the Resale Registration Statement exceeds the amount of damages that such Holder has otherwise been required to pay by reason
of such untrue or alleged untrue statement or omission or alleged omission. No person guilty of fraudulent misrepresentation (within
the meaning of Section 11(f) of the Securities Act) shall be entitled to contribution from any person who was not guilty of
such fraudulent misrepresentation.


 




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(d)          The
agreements contained in this Section 2.3 shall survive the sale of the Registrable Securities pursuant to the Resale Registration
Statement and shall remain in full force and effect, regardless of any termination or cancellation of this Agreement or any investigation
made by or on behalf of any Indemnified Party.


 


Article
III.

Transfer Restrictions


 


3.1          Transfer
Restrictions. Each Holder acknowledges and agrees to the that the following legend shall be imprinted on any certificate or
book-entry security entitlement evidencing any of the Registrable Securities:


 


THE SECURITIES REPRESENTED HEREBY
HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR UNDER THE SECURITIES
LAWS OF ANY STATE. THESE SECURITIES ARE SUBJECT TO RESTRICTIONS ON TRANSFERABILITY AND RESALE AND MAY NOT BE TRANSFERRED OR RESOLD
EXCEPT AS PERMITTED UNDER THE ACT AND APPLICABLE STATE SECURITIES LAWS, PURSUANT TO REGISTRATION OR EXEMPTION THEREFROM. INVESTORS
SHOULD BE AWARE THAT THEY MAY BE REQUIRED TO BEAR THE FINANCIAL RISKS OF THIS INVESTMENT FOR AN INDEFINITE PERIOD OF TIME. THE
ISSUER OF THESE SECURITIES MAY REQUIRE AN OPINION OF COUNSEL IN FORM AND SUBSTANCE SATISFACTORY TO THE ISSUER TO THE EFFECT THAT
ANY PROPOSED TRANSFER OR RESALE IS IN COMPLIANCE WITH THE ACT AND ANY APPLICABLE STATE SECURITIES LAWS.


 


This legend shall be removed
by the Company from any certificate or book-entry security entitlement evidencing the Registrable Securities upon delivery by the
holder thereof to the Company of a written request to that effect if at the time of such written request (i) a registration statement
under the Securities Act is at that time in effect with respect to the legended security, or (ii) the legended security can be
transferred in a transaction in compliance with Rule 144 under the Securities Act, and, in the case of (ii), upon the request and
in the reasonable discretion of the Company’s transfer agent, the holder of such Registrable Securities executes and delivers
a representation letter that includes customary representations regarding the holding requirements and whether such holder is an
“affiliate” for purposes of Rule 144 under the Securities Act. The Company represents and warrants to the Purchasers
that the Company is not currently a shell company (as defined in Rule 405 promulgated under the Securities Act).


 


Article
IV.

Miscellaneous.


 


4.1          Further
Assurances. Each party shall do and perform, or cause to be done and performed, all such further acts and things, and shall
execute and deliver all such other agreements, certificates, instruments and documents, as any other party may reasonably request
in order to carry out the intent and accomplish the purposes of this Agreement and the consummation of the transactions contemplated
hereby.


 




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4.2          Notices.
Any notices, consents, waivers or other communications required or permitted to be given under the terms of this Agreement must
be in writing and will be deemed to have been delivered: (a) upon receipt, when delivered personally; (b) upon receipt, when sent
by e-mail (provided confirmation of transmission is mechanically or electronically generated and kept on file by the sending party);
or (c) one calendar day (excluding Saturdays, Sundays, and national banking holidays in the United States) after deposit with an
overnight courier service, in each case properly addressed to the party to receive the same.


 


The addresses and
e-mail addresses for such communications shall be:


 


If to the Company:


 


Sorrento Therapeutics Inc.


4955 Directors Place


San Diego, California 92121


E-mail: hji@sorrentotherapeutics.com

Attn: Henry Ji, Ph.D.


 


With a copy (which shall not constitute
notice) to:


 


Paul Hastings LLP


4747 Executive Drive, 12th Floor


San Diego, CA 92121


E-mail: jeffhartlin@paulhastings.com


Attn: Jeffrey Hartlin, Esq.


 


If to a Purchaser: To the address set forth opposite
such Purchaser’s name on Schedule A hereto;


 


or to such other address
and/or e-mail address and/or to the attention of such other person as the recipient party has specified by written notice given
to each other party at least five (5) days prior to the effectiveness of such change.


 


4.3          Headings.
The headings of this Agreement are for convenience of reference and shall not form part of, or affect the interpretation of, this
Agreement.


 


4.4          Counterparts.
This Agreement may be executed in two or more identical counterparts, all of which shall be considered one and the same agreement
and shall become effective when counterparts have been signed by each party and delivered to the other party; provided that
a .pdf or other form of electronic signature shall be considered due execution and shall be binding upon the signatory thereto
with the same force and effect as if the signature were an original, not a .pdf or other form of electronic signature.


 




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4.5          Governing
Law; Arbitration; Venue. This Agreement shall be construed under the laws of the State of California, without regard to principles
of conflicts of law or choice of law that would permit or require the application of the laws of another jurisdiction. The Company
and each of the Purchasers hereby agree that all actions or proceedings arising directly or indirectly from or in connection with
this Agreement shall be litigated only in the Superior Court of the State of California or the United States District Court for
the Southern District of California located in San Diego County, California. The Company and each of the Purchasers consent to
the exclusive jurisdiction and venue of the foregoing courts and consents that any process or notice of motion or other application
to either of said courts or a judge thereof may be served inside or outside the State of California or the Southern District of
California by generally recognized overnight courier or certified or registered mail, return receipt requested, directed to such
party at its or his address set forth below (and service so made shall be deemed “personal service”) or by personal
service or in such other manner as may be permissible under the rules of said courts. THE COMPANY AND EACH OF THE PURCHASERS HEREBY
WAIVE ANY RIGHT TO A JURY TRIAL IN CONNECTION WITH ANY LITIGATION PURSUANT TO THIS AGREEMENT.


 


4.6          Assignment
and Successors. This Agreement shall be binding upon and inure to the benefit of the parties and their respective successors
and assigns, including any purchasers of the Notes and/or the Warrants.


 


4.7          Entire
Agreement; Amendments. This Agreement supersedes all other prior oral or written agreements between the Purchasers, the Company,
their Affiliates and persons acting on their behalf with respect to the matters discussed herein, and this Agreement and the instruments
referenced herein contain the entire understanding of the parties with respect to the matters covered herein and therein and, except
as specifically set forth herein or therein, none of the Company or any of the Purchasers makes any representation, warranty, covenant
or undertaking with respect to such matters. No provision of this Agreement may be amended, waived or modified other than by an
instrument in writing signed by the Company and: (a) prior to the Closing, the Purchasers purchasing at least a majority of the
aggregate principal amount of the Notes, as set forth on Schedule A hereto,
or (b) after the Closing, the Purchasers holding at least a majority of the aggregate principal amount of the then-outstanding
Notes. Any such amendment, waiver or modification effected in accordance with this Section 4.7 shall be binding upon all
Purchasers and each transferee of the Notes (or the Note Shares) or the Warrants (or the Warrant Shares), each future holder of
all such securities and the Company.


 


4.8          Severability.
If any provision of this Agreement shall be invalid or unenforceable in any jurisdiction, such invalidity or unenforceability shall
not affect the validity or enforceability of the remainder of this Agreement in that jurisdiction or the validity or enforceability
of any provision of this Agreement in any other jurisdiction.


 


4.9          Termination.
This Agreement shall terminate on the date when there are no longer any remaining Registrable Securities or upon the dissolution,
liquidation or winding up of the Company; provided that Section 2.3 of this Agreement shall survive such termination.


 


4.10        No
Third Party Beneficiaries. This Agreement is intended for the benefit of the parties hereto and their respective permitted
successors and assigns, and is not for the benefit of, nor may any provision hereof be enforced by, any other person.


 




    	 	11	 



     


    

 


4.11        Language;
Currency. This Agreement has been prepared in the English language and the English language shall control its interpretation.
In addition, all notices required or permitted to be given hereunder, and all written, electronic, oral or other communications
between the parties regarding this Agreement, shall be in the English language. All references to “$” contained in
this Agreement shall refer to United States Dollars unless otherwise stated.


 


[The
remainder of this page intentionally left blank]


 




    	 	12	 



     


    

 


IN WITNESS WHEREOF,
the parties hereto have duly executed this Registration Rights Agreement as of the date first written above.


 


	 	THE COMPANY:
	 	 
	 	Sorrento Therapeutics, Inc.,
	 	a Delaware corporation
	 	 	 
	 	By:	/s/ Henry Ji, Ph.D.
	 	 	Name: Henry Ji, Ph.D. 
	 	 	Title: President and Chief Executive Officer


 


[Signature Page to Registration
Rights Agreement]


 




     


     


    

  


IN WITNESS WHEREOF,
the parties hereto have duly executed this Registration Rights Agreement as of the date first written above.


 


	 	PURCHASERS:
	 	 
	 	Magnum Opus2 International Holdings Limited
	 	 	 
	 	By:	/s/ KAM Yuen
	 	 	Name: KAM Yuen
	 	 	Title: Director


 


[Signature Page to Registration
Rights Agreement]


 




     


     


    




 


IN WITNESS WHEREOF,
the parties hereto have duly executed this Registration Rights Agreement as of the date first written above.


 


	 	PURCHASERS:
	 	 
	 	Famous Sino Limited
	 	 	 
	 	By:	/s/ WU Guangze
	 	 	Name: WU Guangze
	 	 	Title: Director


 


[Signature Page to Registration
Rights Agreement]


 




     


     


    

 


IN WITNESS WHEREOF,
the parties hereto have duly executed this Registration Rights Agreement as of the date first written above.


 


	 	PURCHASERS:
	 	 
	 	Top Path Asia Limited
	 	 	 
	 	By:	/s/ XU Ling
	 	 	Name: XU Ling
	 	 	Title: Director


 


[Signature Page to Registration
Rights Agreement]


 




     


     


    

 


IN WITNESS WHEREOF,
the parties hereto have duly executed this Registration Rights Agreement as of the date first written above.


 


	 	PURCHASERS:
	 	 
	 	Hongguo International Holdings Limited
	 	 	 
	 	By:	/s/ CHEN Yixi
	 	 	Name: CHEN Yixi
	 	 	Title: Director


 


[Signature Page to Registration
Rights Agreement]


 




     


     


    

 


 


IN WITNESS WHEREOF,
the parties hereto have duly executed this Registration Rights Agreement as of the date first written above.


 


	 	PURCHASERS:
	 	 
	 	China In Shine Investment Limited
	 	 	 
	 	By:	/s/ ZHANG Yongtie
	 	 	Name: ZHANG Yongtie
	 	 	Title: Director


 


[Signature Page to Registration
Rights Agreement]


 




     


     


    

 


Schedule
A


 


Purchasers


 


	Purchaser	 	Contact Information
 for Notices	 	Principal Amount
 of Note Purchased	 	 	Shares Issuable
 Upon Conversion
 of Notes	 	 	Shares Issuable
 Upon Exercise of
 Warrants	 	 	Total
 Registrable
 Securities	 
	Magnum Opus2 International Holdings Limited	 	48/F, Bank of China Tower 
1 Garden Road
 Central, Hong Kong	 	$	10,000,000	 	 	 	4,407,713	 	 	 	2,424,242	 	 	 	6,831,955	 
	Famous Sino Limited	 	P.O. Box 957 
Offshore Incorporations Centre Road Town 
Tortola, British Virgin Islands	 	$	10,000,000	 	 	 	4,407,713	 	 	 	2,424,242	 	 	 	6,831,955	 
	Top Path Asia Limited	 	Rooms 1102-3, 11/F, Regent Centre 
88 Queen’s Road Central, Hong Kong	 	$	10,000,000	 	 	 	4,407,713	 	 	 	2,424,242	 	 	 	6,831,955	 
	Hongguo International Holdings Limited	 	Room 2904, 29/F 
Far East Finance Centre 
16 Harcourt Road Admiralty, Hong Kong	 	$	10,000,000	 	 	 	4,407,713	 	 	 	2,424,242	 	 	 	6,831,955	 
	China In Shine Investment Limited	 	18/F 
9 Des Voeux Road West 
Hong Kong	 	$	10,000,000	 	 	 	4,407,713	 	 	 	2,424,242	 	 	 	6,831,955	 
		 	TOTAL	 	$	50,000,000	 	 	 	22,038,565	 	 	 	12,121,210	 	 	 	34,159,775	 



 




    Schedule A


     


    




 


Exhibit
A


 


Form
of Selling Stockholder Questionnaire


 


SORRENTO THERAPEUTICS, INC.



SELLING STOCKHOLDER NOTICE AND QUESTIONNAIRE


 


The undersigned holder
of convertible promissory notes and warrants issued by Sorrento Therapeutics, Inc. (the “Company”) understands
that the Company intends to file with the Securities and Exchange Commission a registration statement on Form S-3 (the “Resale
Registration Statement”) for the registration and the resale under Rule 415 of the Securities Act of 1933, as amended
(the “Securities Act”), of the Registrable Securities in accordance with the terms of the Registration
Rights Agreement, dated December 21, 2017, by and among the Company and the several signatories thereto (the “Registration
Rights Agreement”). All capitalized terms not otherwise defined herein shall have the meanings ascribed thereto
in the Registration Rights Agreement.


 


In order to sell or otherwise
dispose of any Registrable Securities pursuant to the Resale Registration Statement, a holder of Registrable Securities generally
will be required to be named as a selling stockholder in the related prospectus or a supplement thereto (as so supplemented, the
“Prospectus”), deliver the Prospectus to purchasers of Registrable Securities (including pursuant to
Rule 172 under the Securities Act) and be bound by the provisions of the Registration Rights Agreement (including certain indemnification
provisions, as described therein). Holders must complete and deliver this notice and questionnaire (“Notice and Questionnaire”)
in order to be named as selling stockholders in the Prospectus. Certain legal consequences arise from being named as a selling
stockholder in the Resale Registration Statement and the Prospectus. Holders of Registrable Securities are advised to consult their
own securities law counsel regarding the consequences of being named or not named as a selling stockholder in the Resale Registration
Statement and the Prospectus.


 


NOTICE


 


The undersigned holder
(the “Selling Stockholder”) of Registrable Securities hereby gives notice to the Company of its intention
to sell or otherwise dispose of Registrable Securities owned by it and listed below in Part 3(b) pursuant to the Resale Registration
Statement. The undersigned, by signing and returning this Notice and Questionnaire, understands and agrees that it will be bound
by the terms and conditions of this Notice and Questionnaire and the Registration Rights Agreement.


 


The undersigned hereby
provides the following information to the Company and represents and warrants that such information is materially accurate and
complete:


 




    	 	A-1	 



     


    

 


QUESTIONNAIRE


 


PART 1. Name:


 


		1.1	Full legal name of the Selling Stockholder:
	 	 	 
	 	 	 



 


		1.2	Full legal name of the registered holder (if not the same
as Part 1(a) above) through which the Registrable Securities listed in Part(3) below are held:
	 	 	 
	 	 	 



 


		1.3	Full legal name of any natural control person (which means
a natural person who directly or indirectly alone or with others has power to vote or dispose of the Registrable Securities listed
in Part (3) below):
	 	 	 
	 	 	 



 


PART II. Notices to Selling Stockholder:


 


		(a)	Address:
	 	 	 
	 	 	 



 


		(b)	Telephone:
	 	 	 
	 	 	 



 


		(c)	Fax:
	 	 	 
	 	 	 



 


		(d)	Contact person:
	 	 	 
	 	 	 



 


		(e)	E-mail address of contact person:
	 	 	 
	 	 	 



  




    	 	A-2	 



     


    

 


 


PART III. Beneficial Ownership of Registrable
Securities:


 


		(a)	Type and number of Registrable Securities beneficially
owned:
	 	 	 
	 	 	 
	 	 	 



  


		(b)	Number of shares of Common Stock to be registered for resale
pursuant to this Notice and Questionnaire:
	 	 	 
	 	 	 
	 	 	 






 


PART IV. Broker-Dealer Status:


 


		(a)	Are you a broker-dealer?



 


Yes  ̈        No
 ̈


 


		(b)	If you answered “yes” to Part 4(a) above, did
you receive your Registrable Securities as compensation for investment banking services provided to the Company?



 


Yes  ̈        No
 ̈


 


Note:If you answered “no”,
the SEC’s staff has indicated that you should be identified as an underwriter in the Resale Registration Statement.


 


		(c)	Are you an affiliate of a broker-dealer?



 


Yes  ̈        No
 ̈


 


If you answered “yes”,
provide a narrative explanation below:


 


	 
	 
	 


 


		(d)	If you are an affiliate of a broker-dealer, do you certify
that you bought the Registrable Securities in the ordinary course of business, and at the time of the purchase of the Registrable
Securities to be resold, you had no agreements or understandings, directly or indirectly, with any person to distribute the Registrable
Securities?



 


Yes  ̈        No
 ̈


 


Note:If you answered “no”,
the SEC’s staff has indicated that you should be identified as an underwriter in the Resale Registration Statement.


 




    	 	A-3	 



     


    

 


		PART V.	Beneficial Ownership of Other Securities of the Company
Owned by the Selling Stockholder:



 


Except as set forth below
in this Part 5, the undersigned is not the beneficial or registered owner of any securities of the Company, other than the Registrable
Securities listed above in Part 3.


 


Type and amount of other
securities beneficially owned:


 


	 
	 
	 


 


		PART VI.	Relationships with the Company:



 


		(a)	Have you or any of your affiliates, officers, directors
or principal equity holders (owners of 5% or more of the equity securities of the undersigned) held any position or office or
have you had any other material relationship with the Company (or its predecessors or affiliates) within the past three years?



 


Yes  ̈        No
 ̈


 


		(b)	If your response to Part 6(a) above is “yes”,
please state the nature and duration of your relationship with the Company:



 


	 
	 
	 
	 


 


		PART VII.	Plan of Distribution:



 


The undersigned has reviewed
the form of Plan of Distribution attached as Annex A hereto, and hereby confirms that, except as set forth below, the information
contained therein regarding the undersigned and its plan of distribution is correct and complete.


 


State any exceptions here:


 


	 
	 


 


	 


 




    	 	A-4	 



     


    

 


The undersigned agrees
to promptly notify the Company of any inaccuracies or changes in the information provided herein that may occur subsequent to the
date hereof and prior to the effective date of any applicable Resale Registration Statement. All notices hereunder shall be delivered
as set forth in the Registration Rights Agreement. In the absence of any such notification, the Company shall be entitled to continue
to rely on the accuracy of the information in this Notice and Questionnaire.


 


By signing below, the undersigned
consents to the disclosure of the information contained herein in its answers to Parts 1 through 7 above and the inclusion of such
information in the Resale Registration Statement and the Prospectus. The undersigned understands that such information will be
relied upon by the Company in connection with the preparation or amendment of any such Resale Registration Statement and Prospectus.


 


By signing below, the undersigned
acknowledges that it understands its obligation to comply, and agrees that it will comply, with the provisions of the Exchange
Act and the rules and regulations thereunder, particularly Regulation M in connection with any offering of Registrable Securities
pursuant to the Resale Registration Statement. The undersigned also acknowledges that it understands that the answers to this Notice
and Questionnaire are furnished for use in connection with registration statements filed pursuant to the Registration Rights Agreement
and any amendments or supplements thereto filed with the SEC pursuant to the Securities Act.


 


The undersigned confirms
that, to the best of his/her knowledge and belief, the foregoing answers to this Notice and Questionnaire are correct.


 


IN WITNESS WHEREOF, the
undersigned, by authority duly given, has caused this Notice and Questionnaire to be executed and delivered either in person or
by its duly authorized agent.


 


Dated: _____________


 


	 	Selling Stockholder:
	 	 
	 	 
	 	Name of Entity or Individual
	 	 
	 	By:	 
	 	Name:	 
	 	Title:	 


 




    	 	A-5