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                          EXHIBIT 12.1 STATEMENT REGARDING COMPUTATION OF RATIOS

                               US ONCOLOGY, INC.
               COMPUTATION OF RATIO OF EARNINGS TO FIXED CHARGES

<TABLE>
<CAPTION>
                                                                    2001      2000      1999      1998      1997
<S>                                                               <C>       <C>       <C>       <C>       <C>
Net income (loss) per the Consolidated Statement
 of Operations                                                    $46,316   $(72,643)  $48,155   $59,981   $15,635
                                                                  =======   ========   =======   =======   =======
Fixed charges                                                     $44,126   $ 46,735   $38,303   $27,529   $21,768
                                                                  =======   ========   =======   =======   =======
Ratio of earnings to fixed charges                                    1.0                 1.3       2.2       0.7
                                                                  =======   ========   =======   =======   =======
Amount by which fixed charges exceed earnings                                119,378
                                                                  =======   ========   =======   =======   =======

                                                      Detail of Fixed Charges

Interest charges per the Consolidated Statement
 of Operations                                                    $22,511   $ 26,809   $22,288   $15,908   $12,474
Add:
 Amortization of debt expense                                       1,185        701       471
 Portion of rental expense representative of
   interest factor (1)                                             20,430     19,225    15,544    11,621     9,294
                                                                  -------   --------   -------   -------   -------
                                                                  $44,126   $ 46,735   $38,303   $27,529   $21,768
                                                                  =======   ========   =======   =======   =======
-----------
(1)  Interest factor based on management's estimates and approximates one-third
     of rental expense.
</TABLE>
                                US ONCOLOGY, INC.
          COMPUTATION OF RATIO OF ADJUSTED EARNINGS TO FIXED CHARGES
<TABLE>
<CAPTION>
                                                                   2001        2000       1999     1998     1997
<S>                                                            <C>         <C>         <C>       <C>       <C>
Net income (loss) per the Consolidated Statement
 of Operations                                                   $ 46,316   $(72,643)  $ 48,155   $ 59,981   $15,635
Minority interest                                                  (1,997)      (944)      (634)      (540)     (437)
Income taxes                                                       28,388    (35,047)    32,229     36,184    11,593
Fixed charges                                                      44,126     46,735     38,303     27,529    21,768
Unusual items:                                                          -          -          -          -         -
 Bad debt expense                                                             10,198                          37,841
 Impairment, restructuring and other charges                        5,868    201,846     29,014
 Gain on investment in common stock                                          (27,566)   (14,431)
                                                                 --------   --------   --------   --------   -------
Adjusted earnings                                                $122,701   $122,579   $132,636   $123,154   $86,400
                                                                 ========   ========   ========   ========   =======
Fixed charges                                                    $ 44,126   $ 46,735   $ 38,303   $ 27,529   $21,768
                                                                 ========   ========   ========   ========   =======
Ratio of adjusted earnings to fixed charges                          2.78       2.62       3.46       4.47      3.97
                                                                 ========   ========   ========   ========   =======

                                                      Detail of Fixed Charges

Interest charges per the Consolidated Statement
 of Operations                                                   $ 22,511   $ 26,809   $ 22,288   $ 15,908   $12,474
Add:
 Amortization of debt expense                                       1,185        701        471
 Portion of rental expense representative of
   interest factor (1)                                             20,430     19,225     15,544     11,621     9,294
                                                                 --------   --------   --------   --------   -------
                                                                 $ 44,126   $ 46,735   $ 38,303   $ 27,529   $21,768
                                                                 ========   ========   ========   ========   =======
</TABLE>
(1)  Interest factor based on management's estimates and approximates one-third
of rental expense.