Exhibit 4.04


 


CONFIDENTIAL
TREATMENT REQUESTED. CERTAIN PORTIONS OF THIS DOCUMENT HAVE BEEN OMITTED PURSUANT TO A REQUEST FOR CONFIDENTIAL TREATMENT AND,
WHERE APPLICABLE, HAVE BEEN MARKED WITH AN ASTERISK TO DENOTE WHERE OMISSIONS HAVE BEEN MADE. THE CONFIDENTIAL MATERIAL HAS BEEN
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION.





 





 


 


 


 


 


 


 


 



 


 


 


AMENDED AND RESTATED


 


 


STOCKHOLDER AGREEMENT


 


 


Dated as of August 7, 2017


 


 


 


 



 


 


 


 


 






     


     

    

TABLE OF CONTENTS


 


 





	 	 	 	 	Page
	 	 	 	 	 
	ARTICLE I
	 	 	 	 	 
	DEFINITIONS
	 	 	 	 	 
	Section 1.1. 	 	Definitions	 	2
	Section 1.2. 	 	General Interpretive Principles 	 	6
	 	 	 	 	 
	ARTICLE II
	 	 	 	 	 
	GOVERNANCE
	 	 	 	 	 
	Section 2.1. 	 	Board of Directors	 	7
	 	 	 	 	 
	ARTICLE III
	 	 	 	 	 
	TRANSFER RESTRICTIONS
	 	 	 	 	 
	Section 3.1. 	 	General Transfer Restrictions 	 	10
	Section 3.2. 	 	Specific Transfer Restrictions	 	10
	Section 3.3. 	 	Permitted Transfers. 	 	11
	 	 	 	 	 
	ARTICLE IV
	 	 	 	 	 
	SHARE OWNERSHIP
	 	 	 	 	 
	Section 4.1. 	 	Standstill 	 	12
	Section 4.2. 	 	Preemptive Rights	 	13
	 	 	 	 	 
	ARTICLE V
	 	 	 	 	 
	REGISTRATION RIGHTS
	 	 	 	 	 
	Section 5.1. 	 	Certain Definitions	 	16
	Section 5.2. 	 	Registration	 	17
	Section 5.3. 	 	Piggyback Registration	 	21
	Section 5.4. 	 	Expenses of Registration	 	22
	Section 5.5. 	 	Obligations of the Company 	 	23
	Section 5.6. 	 	Indemnification	 	25
	Section 5.7. 	 	Information by Holder 	 	27
	Section 5.8. 	 	Transfer of Registration Rights	 	27
	Section 5.9. 	 	Delay of Registration 	 	27
	Section 5.10. 	 	Termination of Registration Rights 	 	27



 



     


     

    




	ARTICLE VI
	 	 	 	 	 
	ADDITIONAL AGREEMENTS OF THE PARTIES
	 	 	 	 	 
	Section 6.1.	 	Protective Provisions	 	28
	Section 6.2.	 	Right of First Negotiation; Toll Manufacturing Option.	 	28
	Section 6.3.	 	Further Assurances	 	29
	Section 6.4.	 	Tranche II Funding	 	29
	 	 	 	 	 
	ARTICLE VII
	 	 	 	 	 
	TERMINATION
	 	 	 	 	 
	Section 7.1.	 	Termination	 	30
	 	 	 	 	 
	ARTICLE VIII
	 	 	 	 	 
	MISCELLANEOUS
	 	 	 	 	 
	Section 8.1.	 	Entire Agreement 	 	30
	Section 8.2.	 	Specific Performance	 	30
	Section 8.3.	 	Governing Law 	 	30
	Section 8.4.	 	Amendment and Waiver 	 	30
	Section 8.5.	 	Binding Effect	 	31
	Section 8.6.	 	Notices 	 	31
	Section 8.7.	 	Severability 	 	31
	Section 8.8.	 	Counterparts	 	31







 








     


     

    

AMENDED AND RESTATED 


 


STOCKHOLDER AGREEMENT 


 


This AMENDED AND RESTATED STOCKHOLDER
AGREEMENT is made as of August 7, 2017, by and between Amyris, Inc., a Delaware corporation (“Amyris” or the
“Company”), and DSM International B.V., a Dutch limited liability company (hereinafter referred to as “DSM”).


 


WHEREAS, the Company and DSM previously
entered into that certain Stockholder Agreement dated as of May 11, 2017 (the “Prior Agreement”).


 


WHEREAS, DSM and Company and certain other
investors previously entered into that certain Securities Purchase Agreement, dated as of May 8, 2017 (as may be amended from time
to time, the “Prior Securities Purchase Agreement”), pursuant to which, upon the terms and subject to the conditions
set forth therein, DSM purchased (i) 25,000 shares (the “Tranche I Shares”) of the 17.38% Series B Convertible
Preferred Stock, par value $0.0001 per share, of the Company (the “Preferred Stock”), (ii) warrants (the “Tranche
I Cash Warrants”) to acquire up to 3,968,116 shares of the common stock, $0.0001 per share (the “Common Stock”),
of the Company (such shares, the “Tranche I Cash Warrant Shares”), and (iii) additional warrants to purchase
shares of Common Stock as a result of certain dilutive issuances by the Company (the “Tranche I Anti-Dilution Warrants”
and, together with the Tranche I Cash Warrants, the “Tranche I Warrants,” and the shares of Common Stock issuable
upon exercise of the Tranche I Anti-Dilution Warrants, the “Tranche I Anti-Dilution Warrant Shares” and, together
with the Tranche I Cash Warrant Shares, the “Tranche I Warrant Shares”);


 


WHEREAS, DSM and Company have entered into
the Securities Purchase Agreement, dated as of August 2, 2017 (as may be amended from time to time, the “Securities Purchase
Agreement”), pursuant to which, upon the terms and subject to the conditions set forth therein, DSM agreed to purchase
(i) 25,000 shares (the “Tranche II Shares” and together with the Tranche I Shares, the “Shares”)
of the Preferred Stock, (ii) warrants (the “Tranche II Cash Warrants” and, together with the Tranche I Cash
Warrants, the “Cash Warrants”) to acquire up to 3,968,116 shares of Common Stock (such shares, the “Tranche
II Cash Warrant Shares” and, together with the Tranche I Cash Warrant Shares, the “Cash Warrant Shares”),
and (iii) additional warrants to purchase shares of Common Stock as a result of certain dilutive issuances by the Company (the
“Tranche II Anti-Dilution Warrants” and, together with the Tranche I Anti-Dilution Warrants and the Cash Warrants,
the “Warrants,” and the shares of Common Stock issuable upon exercise of the Tranche II Anti-Dilution Warrants,
the “Tranche II Anti-Dilution Warrant Shares” and, together with the Tranche I Anti-Dilution Warrant Shares
and the Cash Warrant Shares, the “Warrant Shares”); and


 


WHEREAS, as a condition to consummating the
transactions contemplated by the Securities Purchase Agreement, DSM and the Company are required to amend and restate the Prior
Agreement pursuant to this Agreement.


 


NOW, THEREFORE, in consideration
of the mutual covenants and agreements contained herein, the parties mutually agree as follows:


 


 






     


     

    

ARTICLE I


 


DEFINITIONS


 


Section 1.1. Definitions.
As used in this Agreement, the following terms shall have the meanings set forth below:


 


“Adverse Disclosure” means
public disclosure of material non-public information which, in the judgment of the Non-DSM Directors: (i) would be required to
be made in any report or registration statement filed with the SEC by the Company so that such report or registration statement
would not be materially misleading; (ii) would not be required to be made at such time but for the filing, effectiveness or continued
use of such report or registration statement; and (iii) the Company has a bona fide business purpose for not disclosing
publicly.


 


“Affiliate” means, with
respect to any Person, any other Person that controls, is controlled by, or is under common control with such Person. The term
“control”, as used with respect to any Person, means the power to direct or cause the direction of the management
and policies of such Person, directly or indirectly, whether through the ownership of voting securities, by contract or otherwise.
“Controlled” and “controlling” have meanings correlative to the foregoing.


 


“Agreement”
means this Amended and Restated Stockholder Agreement, as the same may be amended, supplemented, restated or modified.


 


“Beneficial Ownership”
and “Beneficially Own” and similar terms have the meaning set forth in Rule 13d-3 under the Exchange Act. For
the avoidance of doubt, and except as otherwise provided herein, DSM will be deemed to Beneficially Own all of the Warrant Shares
issuable upon exercise of the Warrants held by DSM Parent, its Subsidiaries and controlled Affiliates at the time of determination.


 


“Board” means the Board
of Directors of the Company.


 


“Brotas 1” means
the Company’s first purpose-built, large-scale production facility located in Brotas, Brazil.


 


“Brotas 2” means
the Company’s planned second purpose-built, large scale production facility adjacent to Brotas 1, for which ground was broken
in February 2017.


 


“Business Day”
means any day, other than a Saturday, Sunday or one on which banks are authorized or required by law to be closed in San Francisco,
California or Amsterdam, The Netherlands.


 


“Change of Control Transaction”
has the meaning give to such term in the Company’s Certificate of Designation of Preferences, Rights and Limitations of Series
B 17.38% Convertible Preferred Stock.


 


“Closing” has the meaning
set forth in the Securities Purchase Agreement.


 


 



    2


     

    




“Competitor” means those
Persons set forth on Exhibit A attached hereto and their respective Subsidiaries and controlled Affiliates; provided, however,
that the Company may, based on the reasonable determination of the Board, update the Persons set forth on Exhibit A attached
hereto not more than once in any consecutive 12-month period to include any other Persons that compete with any material portion
of the Company’s business as reasonably determined by the Board; provided, further, that (i) the total number of Persons
set forth on Exhibit A shall not exceed seven (7) and (ii) neither DSM Parent nor any of its Subsidiaries or controlled
Affiliates may be added to Exhibit A.


 


“Convertible Securities”
means all outstanding securities exercisable or exchangeable for, or convertible into, Voting Securities, including the Warrants.


 


“DGCL” means the Delaware
General Corporation Law.


 


“Disqualification Event”
means the “bad actor” disqualifying events described in Rule 506(d)(1)(i)-(viii) promulgated under the Securities Act.


 


“Disqualified Designee”
means any director designee to whom any Disqualification Event is applicable, except for a Disqualification Event as to which Rule
506(d)(2)(ii) or (iii) or (d)(3) is applicable.


 


“DSM Director”
means any DSM Nominee who is elected or appointed to the Board.


 


“DSM Nominee”
means an individual that DSM is entitled to nominate for election to the Board pursuant to Section 2.1(a).


 


“DSM Parent”
means Koninklijke DSM N.V., a Dutch public limited company and the ultimate parent of DSM.


 


“Election Notice” shall
have the meaning assigned to in Section 4.2(b).


 


“Exchange Act” means the
Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder, as the same may be amended from
time to time.


 


“Fair Market Value” means
(i) with respect to cash consideration, the total amount of such cash consideration in United States dollars, (ii) with respect
to non-cash consideration consisting of publicly-traded securities, the average daily closing sales price of such securities for
the ten (10) consecutive trading days ending on the trading day immediately preceding the date the Fair Market Value of such securities
is required to be determined hereunder on the principal national securities exchange on which such securities are listed and admitted
to trading, or, if not listed and admitted to trading on any such exchange, the average of the closing bid and asked prices in
the over-the-counter market and (iii) with respect to non-cash consideration not consisting of publicly-traded securities, such
amount as is determined to be the fair market value of the non-cash consideration as of such date in the good faith determination
of the Non-DSM Directors.


 


 



    3


     

    




“Group” shall have the
meaning assigned to it in Section 13(d)(3) of the Exchange Act.


 


“Non-DSM Directors”
means the members of the Board other than the DSM Directors.


 


“Ownership Amount” means,
as of the date of the relevant Election Notice, the sum of (A) the number of Shares (on an as-if-converted-to-Common Stock basis,
disregarding for such purpose any conversion limitations thereon) and shares of Common Stock then held by DSM Parent, its Subsidiaries
and controlled Affiliates, plus (B) the number of Warrant Shares issuable if the Warrants then held by DSM Parent, its Subsidiaries
and controlled Affiliates and that have an exercise price that is greater than the price per Participation Share to be issued in
the applicable Post-Closing Issuance were fully exercised on such date.


 


“Ownership Percentage”
means, as of the date of the relevant Election Notice, a fraction, the numerator of which is the Ownership Amount and the denominator
of which is the total number of outstanding Share Equivalents as of the date of the relevant Election Notice.


 


“Participation Shares”
means the number of Voting Securities or Convertible Securities or any other equity or equity-linked securities (including, for
the avoidance of doubt, convertible debt) proposed to be sold by the Company or one of its Subsidiaries in a Post-Closing Issuance.


 


“Person” means an individual,
partnership, corporation, business trust, joint stock company, trust, unincorporated association, joint venture, limited liability
company or any other entity of whatever nature, and shall include any successor (by merger or otherwise) of such entity.


 


“Post-Closing Issuance”
shall have the meaning assigned to it in Section 4.2(a).


 


“Restricted Shares” means the Shares,
the Warrants and the Warrant Shares.


 


“Rule 144” means Rule 144
under the Securities Act.


 


“Rule 506(d) Related Party”
shall mean with respect to any Person any other Person that is a beneficial owner of such first Person’s securities for purposes
of Rule 506(d) of the Securities Act.


 


“SEC” means the United
States Securities and Exchange Commission.


 


“Securities Act”
means the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder, as the same may be amended
from time to time.


 


“Share Equivalents” means
all outstanding shares of the Common Stock, together with all shares of Common Stock issuable upon exercise, conversion or exchange
of all outstanding Convertible Securities (whether or not then exercisable, convertible or exchangeable), including the Warrant
Shares, that have an exercise, conversion or exchange


 


 



    4


     

    




price that is greater than the price per Participation Share
to be issued in the applicable Post-Closing Issuance.


 


“Shares” shall have the
meaning assigned to it in the preamble.


 


“Subsidiary” means, with
respect to any party, any corporation, partnership, trust, limited liability company or other non-corporate business enterprise
in which such party (or another Subsidiary of such party) holds stock or other ownership interests representing (A) more that 50%
of the voting power of all outstanding stock or ownership interests of such entity, (B) the right to receive more than 50% of the
net assets of such entity available for distribution to the holders of outstanding stock or ownership interests upon a liquidation
or dissolution of such entity or (C) a general or managing partnership interest in such entity.


 


“Tranche I Anti-Dilution
Warrants” shall have the meaning assigned to it in the preamble.


 


“Tranche I Anti-Dilution Warrant
Shares” shall have the meaning assigned to it in the preamble.


 


“Tranche I Cash Warrants”
shall have the meaning assigned to it in the preamble.


 


“Tranche I Cash Warrant
Shares” shall have the meaning assigned to it in the preamble.


 


“Tranche I Shares” shall
have the meaning assigned to it in the preamble.


 


“Tranche I Warrants” shall have the
meaning assigned to it in the preamble.


 


“Tranche I Warrant Shares”
shall have the meaning assigned to it in the preamble.


 


“Tranche II Anti-Dilution
Warrants” shall have the meaning assigned to it in the preamble.


 


“Tranche II Anti-Dilution
Warrant Shares” shall have the meaning assigned to it in the preamble.


 


“Tranche II Cash Warrants”
shall have the meaning assigned to it in the preamble.


 


“Tranche II Cash Warrant
Shares” shall have the meaning assigned to it in the preamble.


 


“Tranche II Funding Amount”
means $25,000,000.


 


“Tranche II Securities”
means the Tranche II Shares, shares of Common Stock issuable upon conversion thereof, the Tranche II Warrants and shares of Common
Stock issuable upon exercise thereof.


 


“Tranche II Shares” shall
have the meaning assigned to it in the preamble.




    5


     

    




“Tranche II Warrants” means
the Tranche II Cash Warrants and the Tranche II Anti-Dilution Warrants.


 


“Transfer” means, directly
or indirectly, to sell, transfer, assign, pledge, encumber, hypothecate or similarly dispose of (by merger, testamentary disposition,
operation of law or otherwise), either voluntarily or involuntarily, or to enter into any contract, option or other arrangement
or understanding with respect to the sale, transfer, assignment, pledge, encumbrance, hypothecation or similar disposition of (by
merger, testamentary disposition, operation of law or otherwise), any Transfer Restricted Shares.


 


“Transfer Restricted Shares”
means any Shares, shares of Common Stock issued upon conversion of the Shares, Warrants or Warrant Shares.


 


“Voting Securities” means
shares of Common Stock and any other securities of the Company that are permitted by their terms to vote generally in the election
of directors. Except as otherwise provided herein, references to the number or percentage of Voting Securities outstanding or Beneficially
Owned will be deemed to include any Warrant Shares issuable upon exercise of the Warrants at the time of determination.


 


“Warrants” shall have the
meaning assigned to it in the preamble.


 


“Warrant Shares” shall have the meaning
assigned to it in the preamble.


 


Section 1.2. General Interpretive Principles.


 


(a)        The
name assigned to this Agreement and the section captions used herein are for convenience of reference only and shall not be construed
to affect the meaning, construction or effect hereof.


 


(b)        Unless
otherwise specified, the terms “hereof,” “herein” and similar terms refer to this Agreement as a whole,
and references herein to Articles or Sections refer to Articles or Sections of this Agreement.


 


(c)        For
purposes of this Agreement, the words, “include,” “includes” and “including,” when used herein,
shall be deemed in each case to be followed by the words “without limitation.”


 


(d)        Any
action that is required to be taken by the Non-DSM Directors or any consent that may be given by the Non-DSM Directors herein shall
require the approval or consent of a majority of the Non-DSM Directors.


 


(e)        The
parties hereto have participated jointly in the negotiation and drafting of this Agreement. If an ambiguity or question of intent
or interpretation arises, this Agreement will be construed as if drafted jointly by the parties and no presumption or burden of
proof will arise favoring or disfavoring any party because of the authorship of any provision of this Agreement.


 


 






    6


     

    

ARTICLE II


 


GOVERNANCE


 


Section 2.1. Board of Directors.


 


(a) Board Representation.


 


(i)        DSM
shall have the following rights in connection with the nomination of individuals for election to the Board:


 


(A) For so long as DSM Beneficially Owns at least
10% of the Company’s outstanding Voting Securities, DSM shall have the right to nominate two individuals for election to
the Board; provided, that one of such individual shall be a member of DSM Parent’s Executive Committee and the other such
individual shall be selected in DSM’s discretion (each such individual, a “DSM Nominee” and collectively,
the “DSM Nominees”); and


 


(B) For so long as DSM Beneficially Owns less than
10% of the Company’s outstanding Voting Securities but greater than 4.5% of the Company’s outstanding Voting Securities,
DSM shall have the right to nominate one individual for election to the Board; provided, that such individuals shall be a member
of DSM Parent’s Executive Committee.


 


(ii)        In
the event that the number of directors that DSM is entitled to nominate to the Board is reduced pursuant to Section 2.1(a)(i)(B),
DSM shall promptly cause one of the DSM Directors to immediately resign, such that the number of remaining DSM Directors serving
on the Board shall equal the number of directors DSM is then entitled to nominate for election to the Board. In the event that
DSM is no longer entitled to nominate a director to the Board pursuant to Section 2.1(a)(i) above, DSM shall promptly cause any
then-serving DSM Directors to immediately resign. If any such director is unwilling to resign, DSM will take all such actions as
are necessary to cause the removal of the director, including voting (or causing to be voted) all of the Voting Securities Beneficially
Owned by it in favor of such removal.


 


(iii)        For
so long as DSM has the right to nominate a DSM Nominee for election pursuant to Section 2.1(a)(i), in connection with each election
of directors, subject to Section 2.1(a)(v), the Company shall nominate such DSM Nominee for election as a director as part of the
management slate that is included in the proxy statement of the Company relating to the election of directors.


 


(iv)        In
the event that any DSM Director shall cease to serve as a director for any reason (other than the resignation or removal of such
director as a result of DSM not having the right to nominate a director pursuant to Section 2.1(a)(i)), subject


 


 


 



    7


     

    




to Section 2.1(a)(v), DSM shall have the right to
designate another DSM Nominee to fill the vacancy resulting therefrom. For the avoidance of doubt, it is understood that the failure
of the stockholders of the Company to elect any DSM Nominee shall not affect the right of DSM to designate a DSM Nominee for election
pursuant to Section 2.1(a)(i) in connection with any future election of directors of the Company.


 


(v)        Notwithstanding
the foregoing, as a condition to any DSM Nominee’s appointment to the Board and nomination for election as a director of
the Company at the Company’s annual meetings of stockholders:


 


		(A)	DSM and such DSM Nominee must in all material respects provide to the Company (1) all information reasonably requested by the
Company that is required to be or customarily disclosed for directors, candidates for directors, and their affiliates in a proxy
statement or other filings under applicable law or regulation or stock exchange rules or listing standards, in each case, relating
to their nomination or election as a director of the Company and (2) information reasonably requested by the Company in connection
with assessing eligibility, independence and other criteria applicable to directors or satisfying compliance and legal or regulatory
obligations, in each case, relating to their nomination or election as a director of the Company, with respect to DSM Parent, its
Subsidiaries and controlled Affiliates and the applicable DSM Nominee, in each case, to the same extent as all other directors
of the Company;



 


		(B)	such DSM Nominee must be qualified to serve as a director of the Company under the DGCL to the same extent as all other directors
of the Company;



 


		(C)	no Disqualification Event shall be applicable to such DSM Nomine except, if applicable, for a Disqualification Event as to
which Rule 506(d)(2)(ii) or (iii) or (d)(3) is applicable;



 


		(D)	such DSM Nominee shall be reasonably acceptable to the Nominating and Governance Committee of the Board; and



 


		(E)	such DSM Nominee must satisfy the requirements set forth in the Company’s Corporate Governance Guidelines, code of conduct
and securities trading policy, in each case as currently in effect with such changes thereto (or such successor policies) as are
applicable to all other directors, as are adopted in good faith by the Board, and do not by their terms adversely impact any DSM
Nominee relative to



 


 


 



    8


     

    




all other directors (provided that, for the avoidance
of doubt, no DSM Nominee shall be required to qualify as an independent director under applicable stock exchange rules or securities
laws and regulations).


 


The Company will make all information requests pursuant
to this Section 2.1(a)(v) in good faith in a timely manner that allows DSM and any DSM Nominee a reasonable amount of time to provide
such information, and will cooperate in good faith with DSM and any DSM Nominee in connection with their efforts to provide the
requested information.


 


(vi)        DSM
hereby covenants and agrees (A) not to designate or participate in the designation of any director designee who, to DSM’s
knowledge, is a Disqualified Designee, (B) that in the event DSM becomes aware that any individual previously designated by DSM
is or has become a Disqualified Designee or that a Disqualification Event has become applicable to DSM or any of its Rule 506(d)
Related Parties, except, if applicable, for a Disqualification Event as to which Rule 506(d)(2)(ii) or (iii) or (d)(3) is applicable,
then DSM shall notify the Company promptly in writing and as promptly as practicable DSM shall take such actions as are necessary
to remove any such Disqualified Designee from the Board and designate a replacement designee who is not a Disqualified Designee,
and (C) for so long as there is a DSM Director, DSM will comply with the Company’s insider trading policy as currently in
effect with such changes thereto (or such successor policies) as are applicable to all other stockholders of the Company that have
rights to designate or nominate members of the Board.


 


(b)        Identity
of the Nominee. The initial DSM Nominees shall be Philip Eykerman and Christoph Goppelsroeder. The Company confirms that each
of Mr. Eykerman and Mr. Goppelsroeder is reasonably acceptable to the Nominating and Governance Committee of the Board. Mr. Eykerman
has previously been appointed to the Board and the Company shall cause Mr. Goppelsroeder to be appointed to the Board on or prior
to the date of the first regular or special meeting of the Board occurring after the Closing and in no event later than November
2, 2017.


 


(c)        D&O
Indemnification. Each DSM Director shall be eligible to enter into an indemnification agreement consistent with the form generally
entered into with the Company’s officers and directors.


 


(d)        Committees.
At least one DSM Director shall be entitled to serve on each standing committee of the Board other than (i) the Compensation Committee
of the Board, (ii) the Audit Committee of the Board, (iii) the Nominating and Governance Committee of the Board and (iv) any other
committee of the Board for which a DSM Director’s membership would result in a conflict of interest (including, without limitation,
any special committee formed for the purpose of evaluating any transaction between the Company and DSM Parent and/or its Subsidiaries
or controlled Affiliates).


 


 


 






    9


     

    

ARTICLE III


 


TRANSFER RESTRICTIONS 


 


Section 3.1. General
Transfer Restrictions. The right of DSM to Transfer any Transfer Restricted Shares Beneficially Owned by DSM is subject to
the restrictions set forth in this Article III, and no Transfer by DSM of such Transfer Restricted Shares Beneficially Owned by
DSM may be affected except in compliance with this Article III. Any attempted Transfer in violation of this Article III shall be
of no effect and null and void, regardless of whether the purported transferee has any actual or constructive knowledge of the
Transfer restrictions set forth in this Article III, and shall not be recorded on the stock transfer books of the Company.


 


Section 3.2. Specific Transfer Restrictions.


 


(a) Without the prior approval of
the Non-DSM Directors, DSM shall not, and shall not permit DSM Parent or any of its other Subsidiaries or controlled Affiliates
to:


 


(i)        Except
as permitted under Section 3.3, Transfer any Transfer Restricted Shares to any Person or Group that is or includes a Competitor;
or


 


(ii)        Except
as permitted under Section 3.3, Transfer any Transfer Restricted Shares to any Person or Group prior to May 11, 2018.


 


(b) Other than with respect to any
Transfer permitted by Section 3.3, prior to any Transfer of Transfer Restricted Shares to any Person or Group, DSM shall first
provide the Company with ten (10) days prior written notice of its intent to Transfer any Transfer Restricted Shares. Thereafter,
DSM agrees to negotiate in good faith with the Company with respect to the purchase by the Company or any other third parties introduced
to DSM by the Company of such Transfer Restricted Shares subject to such proposed Transfer.


 


(c) DSM acknowledges that the Restricted
Shares have not been registered under the Securities Act and may not be Transferred except pursuant to an effective registration
statement under the Securities Act or pursuant to an exemption from registration under the Securities Act. DSM covenants that the
Restricted Shares will only be disposed of pursuant to an effective registration statement under, and in compliance with the requirements
of, the Securities Act or pursuant to an available exemption from the registration requirements of the Securities Act, and in compliance
with any applicable state and foreign securities laws. In connection with any Transfer of Restricted Shares other than pursuant
to an effective registration statement or to the Company, or pursuant to Rule 144, the Company may require DSM to provide to the
Company an opinion of counsel selected by the DSM and reasonably acceptable to the Company, the form and substance of which opinion
shall be reasonably satisfactory to the Company, to the effect that such Transfer does not require registration under the Securities
Act. Notwithstanding the foregoing, the Company hereby consents to and agrees to register on the books of the Company and with
its transfer agent, without any legal opinion, except to the extent that


 


 


 



    10


     

    




the transfer agent requests such legal opinion, any
Transfer of Restricted Shares by DSM to DSM Parent or another Subsidiary or controlled Affiliate of DSM Parent, provided that
the Transfer is effected in accordance with Section 3.3.


 


(d) DSM agrees to the imprinting,
so long as is required by this Section 3.2, of a legend in substantially the following form on any certificate evidencing
any of the Restricted Shares:


 


NEITHER THIS SECURITY NOR THE SECURITIES INTO WHICH
THIS SECURITY IS CONVERTIBLE OR EXERCISABLE HAVE BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR APPLICABLE STATE
SECURITIES LAWS. THE SECURITIES MAY NOT BE OFFERED FOR SALE, SOLD, TRANSFERRED OR ASSIGNED (I) IN THE ABSENCE OF (A) AN EFFECTIVE
REGISTRATION STATEMENT FOR THE SECURITIES UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR (B) AN OPINION OF COUNSEL TO THE HOLDER
(IF REQUESTED BY THE COMPANY), IN A FORM REASONABLY ACCEPTABLE TO THE COMPANY, THAT REGISTRATION IS NOT REQUIRED UNDER SAID ACT
OR (II) UNLESS SOLD OR ELIGIBLE TO BE SOLD PURSUANT TO RULE 144 UNDER SAID ACT. NOTWITHSTANDING THE FOREGOING, THE SECURITIES MAY
BE PLEDGED IN CONNECTION WITH A BONA FIDE MARGIN ACCOUNT OR OTHER LOAN OR FINANCING ARRANGEMENT SECURED BY THE SECURITIES.


 


Certificates evidencing the Restricted Shares shall
not be required to contain such legend or any other legend (i) following any sale of such Restricted Shares pursuant to an effective
registration statement (including the Registration Statement) covering the resale of the Restricted Shares, (ii) following any
sale of such Restricted Shares pursuant to Rule 144 if the holder provides the Company with a legal opinion reasonably acceptance
to the Company to the effect that the Restricted Shares were sold under Rule 144 or (iii) if the holder provides the Company with
a legal opinion reasonably acceptable to the Company to the effect that the legend is not required under applicable requirements
of the Securities Act. Notwithstanding anything to the contrary in this Agreement, the Prior Securities Purchase Agreement or the
Securities Purchase Agreement, in the event of any conflict or inconsistency between any provision of Section 3.2(c), Section 3.2(d)
or Article V of this Agreement, on the one hand, and any provision of the Prior Securities Purchase Agreement or the Securities
Purchase Agreement, on the other hand, whichever provision is more favorable to DSM under the circumstances (as determined by DSM
in its sole discretion) will control as between the Company and DSM.


 


Section 3.3. Permitted Transfers.


 


(a) DSM may Transfer any or all
of the Transfer Restricted Shares held by it (i) to DSM Parent or any of its other Subsidiaries or controlled Affiliates, provided
that,


 


 


 



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at or prior to the Transfer, such transferee shall have agreed
with the Company in writing to be bound by all of the terms and condition of this Agreement applicable to DSM, or (ii) in connection
with a Change of Control Transaction or Fundamental Transaction (as such term is defined in the Company’s Certificate of
Designation of Preferences, Rights and Limitations of Series B 17.38% Convertible Preferred Stock), at the consummation of (and
pursuant to the terms of) such transaction.


 


(b) Notwithstanding anything herein to the
contrary, no change in control or ownership of any shares in the capital stock of DSM Parent shall constitute a Transfer for purposes
of this Agreement.


 


ARTICLE IV


 


SHARE OWNERSHIP 


 


Section 4.1. Standstill.


 


(a)        Except
as provided in Section 4.1(b), from the Closing until three months after no DSM Nominee serves on the Board (the “Standstill
Period”), DSM shall not, nor shall it permit DSM Parent or any of its other Subsidiaries or controlled Affiliates to,
directly or indirectly, without the prior consent of the Company (acting through a resolution of the Company’s Non-DSM Directors):


 


(i)        acquire
or agree to acquire, whether by purchase, tender or exchange offer, by forming, joining or otherwise participating in a partnership,
syndicate or other Group, through the use of a derivative instrument or voting agreement, or otherwise, (A) Beneficial Ownership
of additional Voting Securities or Convertible Securities after the Closing that would result in DSM Parent (together with its
Subsidiaries or controlled Affiliates and any parties acting as members of a Group with DSM), having Beneficial Ownership of more
than 33.0% in the aggregate of the shares of Voting Securities outstanding at such time (assuming (1) the exercise of all of then-outstanding
Warrants for the maximum number of shares of Common Stock issuable thereunder, regardless of whether such Warrants are then exercisable,
and (2) the conversion of the Shares for the maximum number of shares of Common Stock issuable thereunder, regardless of whether
such Shares are then convertible, which number of shares shall be included in the numerator and denominator for purposes of determining
the percentage of Voting Securities Beneficially Owned by DSM Parent (together with its Subsidiaries and controlled Affiliates
and any parties acting as members of a Group with DSM) for purposes of this clause (A)), except pursuant to Section 4.2 of this
Agreement, pursuant to the exercise of the Warrants, pursuant to the Prior Securities Purchase Agreement or the Securities Purchase
Agreement or pursuant to the Company’s Certificate of Designation of Preferences, Rights and Limitations of Series B 17.38%
Convertible Preferred Stock, or (B) any direct or indirect ownership interest in any indebtedness or debt securities of the Company
or any of its Subsidiaries, except pursuant to Section 4.2 of this Agreement;


 


 


 



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(ii)        (A)
make, or in any way participate, directly or indirectly, in any “solicitation” of “proxies” (as such terms
are used in the rules of the SEC) to vote Voting Securities, (B) seek to advise or knowingly influence any Person with respect
to the voting of any Voting Securities or (C) deposit any Voting Securities in any voting trust or subject any Voting Securities
to any arrangement or agreement with respect to the voting of any Voting Securities, except for this Agreement;


 


(iii)        make
any public announcement of a proposal or offer (with or without conditions) with respect to any extraordinary transaction involving
DSM Parent or its Subsidiaries or controlled Affiliates and the Company including, without limitation, any tender offer, merger,
consolidation or business combination;


 


(iv)        effect
or seek to effect any recapitalization, reclassification, liquidation or dissolution of the Company;


 


(v)        publicly
disclose any intention, plan or arrangement by DSM regarding the possibility of any of the events described in clauses (i) through
(iv) above;


 


(vi)        knowingly
take any action that would require either the Company or DSM under applicable law or the rules of the principal exchange on which
the Company’s Common Stock is then listed or traded to make a public announcement regarding the possibility of any of the
events described in clauses (i) through (iv) above; or


 


(vii)        enter
into any discussions, negotiations, agreements or understandings with any other third Person (excluding DSM’s advisors) with
respect to any of the foregoing.


 


(b)        Notwithstanding
the foregoing, the restrictions contained in Section 4.1(a) shall not (1) apply with respect to the designations of the DSM Nominees
in accordance with this Agreement, (2) prevent a DSM Director from taking any action in his or her capacity as a director of the
Company, (3) prohibit DSM Parent or any of its Subsidiaries or controlled Affiliates from voting its Voting Securities in its discretion,
(4) apply to the acquisition of securities in or control of another Person (including by way of merger or consolidation) or (5)
apply to any acquisitions or investments by any bona fide employee benefit plan of DSM Parent or its Subsidiaries or controlled
Affiliates. In addition, the restrictions contained in Section 4.1(a) shall not prevent a private communication to the Board to
the extent that such private communication would not reasonably be expected to require a public disclosure prior to any public
announcement by the Company that it (or its Board) has approved or entered into an agreement with respect to a Change of Control
Transaction or Fundamental Transaction.


 


Section 4.2. Preemptive Rights.


 


(a)        Other
than as set forth in Section 4.2(d) and (e), if the Company or any Subsidiary of the Company at any time shall propose to issue
any Voting Securities or


 


 


 



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Convertible Securities or any other equity or equity-linked
securities (including, for the avoidance of doubt, convertible debt) following the Closing in a capital raising transaction for
cash (other than pursuant to the Prior Securities Purchase Agreement or the Securities Purchase Agreement) (a “Post-Closing
Issuance”), DSM shall have the right to purchase for cash directly from the Company or such Subsidiary up to its Ownership
Percentage of such Participation Shares at the same purchase price as the price for the Participation Shares to be issued; provided,
however, that the issuance of securities in connection with the July 2017 PIPE Transaction (as defined in the Securities Purchase
Agreement) shall not be considered a Post-Closing Issuance hereunder.


 


(b)        With
respect to any Post-Closing Issuance, the Company, on behalf of itself or its applicable Subsidiary, will notify DSM in writing
(the “Notice”) stating (i) its bona fide intention to offer such Participation Securities, (ii) the number of
such Participation Securities to be offered, and (iii) the price and terms, if any, upon which it proposes to offer such Participation
Securities.


 


(c)        Within
thirty (30) business days after giving of the Notice, DSM may elect to purchase or obtain, at the price and on the terms specified
in the Notice, up to its Ownership Percentage of such Participation Shares. DSM shall be entitled to allocate, as among DSM Parent
and its Subsidiaries and controlled Affiliates (who agree or have agreed in writing to be bound by the terms of this Agreement),
the number of Participation Shares entitled to be purchased by DSM Parent and its Subsidiaries and controlled Affiliates (collectively)
pursuant to this Section 4.2. In the event that DSM elects to exercise its purchase rights pursuant to this Section 4.2, DSM shall
provide to the Company written notice of such election (the “Election Notice”) to purchase up to its Ownership
Percentage of the Participation Shares hereunder, which notice shall (i) certify the Ownership Amount as of the date of the Election
Notice, (ii) specify the number of Participation Shares to be purchased by DSM Parent and its Subsidiaries and controlled Affiliates
(not to exceed DSM’s Ownership Percentage of the Participation Shares, the “Specified Number”), and (iii)
the allocation of such Participation Shares among DSM Parent and its Subsidiaries and controlled Affiliates. DSM shall, or shall
cause DSM Parent and its other Subsidiaries and controlled Affiliates (as applicable) to, purchase, and the Company shall, or shall
cause its applicable Subsidiary to, issue and sell to DSM Parent and its Subsidiaries and controlled Affiliates (as applicable),
the Specified Number of the Participation Shares concurrently with the related Post-Closing Issuance by the Company or its applicable
Subsidiary.


 


(d)        In
the event that the Post-Closing Issuance which gave rise to the exercise by DSM of its purchase rights pursuant to this Section
4.2 shall be terminated or abandoned by the Company without the issuance of any securities, then the purchase rights of DSM pursuant
to this Section 4.2 shall also terminate as to such proposed Post-Closing Issuance (but not any subsequent or future issuance),
and any funds in respect thereof paid to the Company by DSM shall be refunded in full.


 


(e)        Notwithstanding
the foregoing, the provisions of this Section 4.2 shall not apply to, and DSM shall not have any purchase rights with respect to,
any of the following types of Post-Closing Issuances by the Company or any of its Subsidiaries:


 


 


 



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(i)        any
Post-Closing Issuance of Voting Securities or Convertible Securities to officers, employees, directors or consultants of the Company
in connection with such Person’s employment or consulting arrangements with the Company or the service of such person as
a director;


 


(ii)        any
Post-Closing Issuance of Voting Securities or Convertible Securities (i) in any business combination or acquisition transaction
involving the Company or any of its Subsidiaries or (ii) in connection with the incurrence of indebtedness by the Company or any
of its Subsidiaries (provided that such indebtedness does not constitute a Convertible Security);


 


(iii)        any
Post-Closing Issuance of Voting Securities or Convertible Securities in connection with any stock split, stock dividend or recapitalization
approved by the Board (so long as all holders of the same class or series of Voting Securities is treated equally with all other
holders of such class or series of Voting Securities); or


 


(iv)        any
Post-Closing Issuance of Voting Securities pursuant to a public offering registered under the Securities Act; or


 


(v)        any
Post-Closing Issuance of Voting Securities or Convertible Securities to any Person (or any Affiliate of a Person), which is an
operating company or an owner of an asset in a business synergistic with the Company’s business as determined in good faith
by the Board, to induce such Person to enter into any joint venture or other strategic or commercial relationship with the Company
or any of its Subsidiaries that provides to the Company additional benefits in addition to the investment of funds, as determined
in good faith by the Non-DSM Directors, but shall not include a transaction in which the Company or any of its Subsidiaries is
issuing securities primarily for the purpose of raising capital or to a Person whose primary business is investing in securities
of other Persons.


 


(f)        The
Company may, during the seventy-five (75) day period following the expiration of the period provided in Section 4.2(c) hereof,
offer the remaining unsubscribed portion of such Participation Securities to any Person or Persons at a price not less than, and
upon terms no more favorable to the offeree than, those specified in the Notice. If the Company does not consummate the sale of
such Participation Securities, or enter into a definitive agreement for the sale of such Participation Securities, within such
period, or if the Company enters into such a definitive agreement and such agreement is not consummated within seventy-five (75)
days of the execution thereof, the purchase right pursuant to this Section 4.2 shall be deemed to be revived and no such Participation
Securities shall be offered unless first reoffered to DSM in accordance herewith.


 


 


 






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ARTICLE V


 


REGISTRATION RIGHTS


 


The Company hereby grants to each of the
Holders (as defined below) the registration rights set forth in this Article V, with respect to the Registrable Securities (as
defined below) owned by such Holders.


 


Section 5.1. Certain Definitions. As used
in this Article V:


 


(a) “Effective Date” means
the date that the Initial Registration Statement has been declared effective by the SEC.


 


(b) “Effectiveness
Deadline” means December 22, 2017.


 


(c) “Filing Deadline”
means November 7, 2017.


 


(d)        “Holder”
(collectively, “Holders”) means (i) DSM and (ii) any subsidiary or controlled Affiliate of DSM Parent that DSM
designates in writing as a Holder, in each case to the extent holding Registrable Securities, securities exercisable or convertible
into Registrable Securities or securities exercisable for securities convertible into Registrable Securities. 


 


(e)        “Prospectus”
means the prospectus included in any Registration Statement, all amendments and supplements to such prospectus, including post-effective
amendments, and all other material incorporated by reference in such prospectus.


 


(f)        “register”,
“registered” and “registration” refer to a registration effected by filing with the SEC a
Registration Statement in compliance with the Securities Act, and the declaration or ordering by the SEC of the effectiveness of
such Registration Statement.


 


(g)        “Registrable
Securities” means (i) Underlying Shares held by, or issuable to, Holders and (ii) any shares of Voting Securities issued
as (or issuable upon) a stock split, stock dividend or other distribution with respect to, or in exchange or in replacement of,
such Registrable Securities set forth in clause (i), in each case, until the earliest to occur of (A) the date on which a Registration
Statement covering such securities has been declared effective by the SEC and such security has been disposed of pursuant to such
effective Registration Statement, (B) the date on which such security is sold pursuant to Rule 144, (C) the date on which such
security ceases to be outstanding or (D) the date on which the Holder thereof, together with its Affiliates, is able to dispose
of all of its Registrable Securities in any 90 day period pursuant to Rule 144 (or any similar or analogous rule promulgated under
the Securities Act).


 


(h)        “Registration
Statement” means a registration statement or registration statements of the Company filed under the Securities Act covering
the Registrable Securities.


 


 


 



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(i)        “Required
Registration Amount” means the lesser of (i) 100% of the sum of the maximum number of Underlying Shares issued and issuable
as of the Trading Day immediately preceding the applicable date of determination or (ii) such other amount as may be required by
the staff of the SEC pursuant to Rule 415 with any cutback applied pro rata to all Holders.


 


(j)        “Underlying
Shares” means the Warrant Shares and the shares of Common Stock issuable upon conversion of the Shares.


 


Section 5.2.Registration 


 


(a) (i) Initial Mandatory
Registration. The Company shall use reasonable efforts to prepare, and, as soon as practicable, but in no event later than
the Filing Deadline, file with the SEC a Registration Statement on Form S-3 covering the resale of all of the Registrable Securities
(the “Initial Registration Statement”). The Initial Registration Statement prepared pursuant hereto shall register
for resale at least the number of shares of Common Stock equal to the total number of then outstanding Registrable Securities determined
as of the date the Initial Registration Statement is initially filed with the SEC. The Company shall use its reasonable best efforts
to have the Initial Registration Statement declared effective by the SEC as soon as practicable, but in no event later than the
Initial Effectiveness Deadline. The Company shall use its reasonable efforts to file with the SEC in accordance with Rule 424 under
the Securities Act the final prospectus to be used in connection with sales pursuant to such Initial Registration Statement by
9:30 am on the Business Day following the Effective Date, but in any case no later than the deadline required by Rule 424.


 


(ii)        Additional
Registrations. Notwithstanding anything herein to the contrary, to the extent the staff of the SEC does not permit all of the
Registrable Securities to be registered on the Initial Registration Statement, the Company shall file additional Registration Statements
successively trying to register on each such Registration Statement the maximum number of remaining Registrable Securities until
all of the Registrable Securities have been registered for resale. Each such additional Registration Statement prepared pursuant
hereto shall register for resale at least that number of shares of Common Stock equal to the Additional Registrable Securities
determined as of the date such Additional Registration Statement is initially filed with the SEC. The Company shall use its reasonable
efforts to have each such additional Registration Statement declared effective by the SEC as soon as practicable. The Company shall
file with the SEC in accordance with Rule 424 under the Securities Act the final prospectus to be used in connection with sales
pursuant to such additional Registration Statement by 9:30 am on the Business Day following the effective date of such Registration
Statement, but in any case no later than the deadline required by Rule 424.


 


(iii)        Underwritten
Registrations. With respect to any of the registrations contemplated by this Section 5.2(a), DSM may request that up to three
such registrations provide for an underwritten offering of the Registrable Securities. In connection with any such underwritten
offering, the right of any Holder to registration


 


 


 



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pursuant to this Section 5.2(a)(iv) shall be conditioned
upon such Holder’s participation in such underwriting and the inclusion of such Holder’s Registrable Securities in
the underwriting to the extent provided herein in subject to the limitations expressed in this Section 5.2. All Holders proposing
to distribute their Registrable Securities through such underwriting shall, together with any other parties distributing their
securities through such underwriting, enter into an underwriting agreement in customary form with the underwriter or underwriters
selected for such underwriting by the Company. Notwithstanding any other provision of this Section 5.2, if the underwriter determines
that marketing factors require a limitation of the number of shares to be underwritten, the underwriter may limit the number of
Registrable Securities to be included in the registration and underwriting.


 


(iv) Subject to the provisions of
this Section 5.2 and further subject to the availability of a Registration Statement on Form S-3 (or any successor form thereto)
to the Company pursuant to the Securities Act and the rules and interpretations of the SEC, the Company will use its reasonable
efforts to keep the Initial Registration Statement (or any replacement Registration Statement) continuously effective until the
earlier of: (A) the date on which all Registrable Securities covered by the Registration Statement have been sold thereunder in
accordance with the plan and method of distribution disclosed in the prospectus included in the Registration Statement and (B)
there otherwise cease to be any Registrable Securities.


 


(v) Allocation of Registrable
Securities. The initial number of Registrable Securities included in any Registration Statement and any increase or decrease
in the number of Registrable Securities included therein shall be allocated pro rata among the Holders based on the number of Registrable
Securities held by each Holder at the time the Registration Statement covering such initial number of Registrable Securities or
increase or decrease thereof is declared effective by the SEC. In the event that a Holder sells or otherwise transfers any of such
Holder’s Registrable Securities, each transferee that becomes a Holder shall be allocated a pro rata portion of the then
remaining number of Registrable Securities included in such Registration Statement for such transferor. Any shares of Common Stock
included in a Registration Statement and which remain allocated to any Person which ceases to hold any Registrable Securities covered
by such Registration Statement shall be allocated to the remaining Holders, pro rata based on the number of Registrable Securities
then held by such Holders which are covered by such Registration Statement.


 


(b)        Suspension
of Filing or Registration. If the Company shall furnish to the Holders a certificate signed by the Chief Executive Officer
or Chief Financial Officer of the Company, stating that the filing, effectiveness or continued use of a Registration Statement
would require the Company to make an Adverse Disclosure, then the Company shall have a period of not more than 75 days (or such
longer period as DSM shall consent to in writing) within which to delay the filing or effectiveness of such Registration Statement
or, in the case of a Registration Statement that has been declared effective, to suspend the use by Holders of such Registration
Statement (in each case, a “Shelf Suspension”); provided, however, that, unless consented to in
writing by the DSM, the Company shall not be permitted to exercise a Suspension more than twice during any 12-


 


 


 



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month period for each Shelf Registration Statement.
In the case of a Shelf Suspension that occurs after the effectiveness of a Registration Statement, the Holders agree to suspend
use of the applicable Prospectus in connection with any sale or purchase of, or offer to sell or purchase, Registrable Securities,
upon receipt of the notice referred to above. The Company shall immediately notify the Holders upon the termination of any Shelf
Suspension, and (i) in the case of a Registration Statement that has not been declared effective, shall promptly thereafter file
a Registration Statement and use its reasonable best efforts to have such Registration Statement declared effective under the Securities
Act and (ii) in the case of an effective Registration Statement, shall amend or supplement the Prospectus, if necessary, so it
does not contain any untrue statement or omission and furnish to the Holders such numbers of copies of the Prospectus as so amended
or supplemented as the Holders may reasonably request. The Company agrees, if necessary, to supplement or make amendments to the
applicable Registration Statement, if required by the registration form used by the Company for the shelf registration or by the
instructions applicable to such registration form or by the Securities Act or the rules or regulations promulgated thereunder.


 


(c)        The
Company shall use its commercially reasonable efforts to take all actions reasonably necessary to ensure that the transactions
contemplated herein are effected as so contemplated in Section 5.2(a) hereof, and to submit to the SEC, within five Business Days
after the Company learns that no review of a Registration Statement will be made by the staff of the SEC or that the staff has
no further comments on a Shelf Registration Statement, as the case may be, a request for acceleration of effectiveness (or post
effective amendment, if applicable) of such Registration Statement to a time and date not later than 48 hours after the submission
of such request.


 


(d)        Any
reference herein to a registration statement or prospectus as of any time shall be deemed to include any document incorporated,
or deemed to be incorporated, therein by reference as of such time and any reference herein to any post-effective amendment to
a registration statement as of any time shall be deemed to include any document incorporated, or deemed to be incorporated, therein
by reference as of such time. Any reference to a prospectus as of any time shall include any supplement thereto, preliminary prospectus,
or any free writing prospectus in respect thereof.


 


(e)        In
connection with the filing of a Registration Statement, the Company shall:


 


(i)        prepare
and file with the SEC within the time periods specified in Section 5.2(a), a Registration Statement on any form which may be utilized
by the Company and which shall register all of the Registrable Securities for resale by the holders thereof in accordance with
such method or methods of disposition (but which shall not include an underwritten offering as to which the Company needs to assist)
as may be specified by DSM and use reasonable best efforts to cause such Registration Statement to become effective as soon as
reasonably practicable but in any case within the time periods specified in Section 5.2(a);


 


 


 



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(ii)        as
soon as reasonably practicable prepare and file with the SEC such amendments and supplements to such Registration Statement (including
without limitation, any required post effective amendments) and the prospectus included therein as may be necessary to effect and
maintain the effectiveness of such Registration Statement for the period specified in Section 5.2(a) hereof and as may be required
by the applicable rules and regulations of the SEC and the instructions applicable to the form of such Registration Statement;


 


(iii)        comply
with the provisions of the Securities Act with respect to the disposition of all of the Registrable Securities covered by such
Registration Statement in accordance with the intended methods of disposition by DSM provided for in such Registration Statement;


 


(iv)        provide
DSM and its legal counsel (“Legal Counsel”) a reasonable opportunity to participate in the preparation of such
Registration Statement, each prospectus included therein or filed with the SEC and each amendment or supplement thereto (but not
including any documents incorporated by reference), in each case subject to customary confidentiality restrictions, and give reasonable
consideration to any comments Legal Counsel provides with respect to any Shelf Registration Statement or amendment or supplement
thereto. The Company shall furnish to Legal Counsel copies of any correspondence from the SEC or the staff of the SEC to the Company
or its representatives relating to any Registration Statement;


 


(v)        promptly
notify DSM (A) when such Registration Statement or the Prospectus included therein or any prospectus amendment or supplement or
post-effective amendment has been filed, and, with respect to such Registration Statement or any post-effective amendment, when
the same has become effective, (B) of any comments by the SEC with respect thereto or any request by the SEC for amendments or
supplements to such Registration Statement or prospectus or for additional information, (C) of the issuance by the SEC of any stop
order suspending the effectiveness of such Registration Statement or the initiation or threatening of any proceedings for that
purpose, (D) of the receipt by the Company of any notification with respect to the suspension of the qualification of the Registrable
Securities for sale in any jurisdiction or the initiation or threatening of any proceeding for such purpose, or (E) if at any time
when a prospectus is required to be delivered under the Securities Act, that such Registration Statement, prospectus, prospectus
amendment or supplement or post-effective amendment does not conform in all material respects to the applicable requirements of
the Securities Act and the rules and regulations of the SEC thereunder or contains an untrue statement of a material fact or omits
to state any material fact required to be stated therein or necessary to make the statements therein not misleading in light of
the circumstances then existing; and


 


(vi)        in
the event that Form S-3 is not available for the registration of the resale of Registrable Securities hereunder, the Company shall
(i) register the resale of the Registrable Securities on another appropriate form reasonably acceptable to DSM and (ii) undertake
to register the Registrable Securities on Form S-3 as soon as such form is available, provided that the Company shall maintain
the


 


 


 



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effectiveness of the Registration Statement then in
effect until such time as a Registration Statement on Form S-3 covering the Registrable Securities has been declared effective
by the SEC.


 


(f)        In
connection with a shelf registration, the Company may require each Holder whose Registrable Securities are covered by the shelf
registration, to furnish to the Company such information regarding the Holder, including, without limitation, its intended method
of distribution of Registrable Securities as may be required in order to comply with the Securities Act. The Holder agrees to notify
the Company as promptly as practicable of any inaccuracy or change in information previously furnished by the Holder to the Company
or of the occurrence of any event in either case that could cause the prospectus to contain an untrue statement of a material fact
regarding the Holder or its intended method of disposition of such Registrable Securities or omits to state any material fact regarding
the Holder or its intended method of disposition of such Registrable Securities required to be stated therein or necessary to make
the statements therein not misleading in light of the circumstances then existing, and promptly to furnish to the Company any additional
information required to correct and update any previously furnished information or required so that such prospectus shall not contain,
with respect to the Holder or the disposition of such Registrable Securities, an untrue statement of a material fact or omit to
state a material fact required to be stated therein or necessary to make the statements therein not misleading in light of the
circumstances then existing. If the Holder fails to provide to the Company any information required to be provided pursuant to
this Section 5.2 after the Holder became aware of the inaccuracy, omission or required change, the Company may suspend the use
of the Registration Statement and the prospectus contained therein until such time as the Holder provides the required information
to the Company.


 


Section 5.3. Piggyback Registration.


 


(a)        Company
Registration. If at any time or from time to time the Company shall determine to register any of its equity securities, either
for its own account or for the account of security holders (other than (1) in a registration relating solely to employee benefit
plans, (2) a registration on Form S-4 or S-8 (or such other similar successor forms then in effect under the Securities Act), (3)
a primary registration of securities under Rule 415 of the Securities Act, (4) a registration pursuant to which the Company is
offering to exchange its own securities, (5) a registration statement relating solely to dividend reinvestment or similar plans,
(6) a resale shelf registration statement relating solely to debt securities of the Company that are convertible into Common Stock
and the underlying shares of Common Stock or (7) a registration pursuant to Section 5.2), the Company will:


 


(i)        promptly
(but in no event less than 10 days before the effective date of the relevant Registration Statement) give to each Holder written
notice thereof; and


 


(ii)        include
in such registration (and any related qualification under state securities laws or other compliance), and in any underwriting involved


 


 


 



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therein, all the Registrable Securities specified
in a written request or requests, made within 5 days after receipt of such written notice from the Company, by any Holder or Holders,
subject, in each case, to the limitations expressed in Section 5.2 and except as set forth in Section 5.3(b) below.


 


(b)        Underwriting.
If the registration of which the Company gives notice is for a registered public offering involving an underwriting, the Company
shall so advise the Holders as a part of the written notice given pursuant to Section 5.3(a)(i). In such event the right of any
Holder to registration pursuant to this Section 5.3 shall be conditioned upon such Holder’s participation in such underwriting
and the inclusion of such Holder’s Registrable Securities in the underwriting to the extent provided herein in subject to
the limitations expressed in Section 5.2. All Holders proposing to distribute their Registrable Securities through such underwriting
shall, together with the Company and the other parties distributing their securities through such underwriting, enter into an underwriting
agreement in customary form with the underwriter or underwriters selected for such underwriting by the Company. Notwithstanding
any other provision of this Section 5.3, if the underwriter determines that marketing factors require a limitation of the number
of shares to be underwritten, the underwriter may limit the number of Registrable Securities to be included in the registration
and underwriting, subject to the terms of this Section 5.3. The Company shall so advise all holders of the Company’s securities
that would otherwise be registered and underwritten pursuant hereto, and the number of shares of such securities, including Registrable
Securities, that may be included in the registration and underwriting shall be allocated first to the Company and second
to the Holders and any other holders with registration rights on a pro rata basis based on the total number of Registrable
Securities held by the Holders and such other holders. No such reduction shall (i) reduce the securities being offered by the Company
for its own account to be included in the registration and underwriting, or (ii) subject to the limitations expressed in Section
5.2, reduce the amount of securities of the selling Holders included in the registration below twenty-five percent (25%) of the
total amount of securities included in such registration by all selling stockholders. No securities excluded from the underwriting
by reason of the underwriter’s marketing limitation shall be included in such registration. For the avoidance of doubt, nothing
in this Section 5.3(b) is intended to diminish the number of securities to be included by the Company in the underwriting.


 


(c)        Right
to Terminate Registration. The Company shall have the right to terminate or withdraw any registration initiated by it under
this Section 5.3 prior to the effectiveness of such registration whether or not any Holder has elected to include securities in
such registration.


 


Section 5.4. Expenses
of Registration. All expenses incurred in connection with all registrations effected pursuant to Sections 5.2 and 5.3, including
all registration, filing and qualification fees (including state securities law fees and expenses), printing expenses, escrow fees,
fees and disbursements of counsel for the Company; provided, however, that the Company shall not be required to pay
the fees of Legal Counsel, stock transfer taxes or underwriters’ discounts or selling commissions relating to Registrable
Securities.


 


 


 



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Section 5.5.Obligations
of the Company. Whenever required under this Article V to effect the registration of any Registrable Securities, the Company
shall (in addition to the requirements set forth in Section 5.2(e) with respect to a Registration Statement), as expeditiously
as reasonably possible:


 


(a)        prepare
and file with the SEC such amendments and supplements to such Registration Statement and the prospectus used in connection with
such Registration Statement as may be necessary to keep such Registration Statement effective and to comply with the provisions
of the Securities Act with respect to the disposition of all securities covered by such registration statement in accordance with
the intended methods of disposition by sellers thereof set forth in such registration statement;


 


(b)        permit
any Holder which Holder, in the reasonable judgment of the Company, if deemed to be a controlling person of the Company, to participate
in good faith in the preparation of such Registration Statement and to cooperate in good faith to include therein material, furnished
to the Company in writing, that in the reasonable judgment of the Company should be included;


 


(c)        furnish
to the Holders such numbers of copies of a prospectus, including all exhibits thereto and documents incorporated by reference therein
and a preliminary prospectus, in conformity with the requirements of the Securities Act, and such other documents as they may reasonably
request in order to facilitate the disposition of Registrable Securities owned by them;


 


(d)        in
the event of any underwritten public offering, enter into and perform its obligations under an underwriting agreement, in usual
and customary form, with the managing underwriter(s) of such offering. Each Holder participating in such underwriting shall also
enter into and perform its obligations under such an agreement;


 


(e)        notify
each Holder of Registrable Securities covered by such Registration Statement as soon as reasonably practicable after notice thereof
is received by the Company of any written comments by the SEC or any request by the SEC or any other federal or state governmental
authority for amendments or supplements to such Registration Statement or such prospectus or for additional information;


 


(f)        notify
each Holder of Registrable Securities covered by such Registration Statement, at any time when a prospectus relating thereto is
required to be delivered under the Securities Act, of the happening of any event as a result of which the prospectus included in
such Registration Statement, as then in effect, includes an untrue statement of a material fact or omits to state a material fact
required to be stated therein or necessary to make the statements therein not misleading in the light of the circumstances then
existing;


 


(g)        notify
each Holder of Registrable Securities covered by such Registration Statement as soon as reasonably practicable after notice thereof
is received by the Company of the issuance by the SEC of any stop order suspending the effectiveness of such Registration Statement
or any order by the SEC or any other regulatory authority


 


 


 



    23


     

    




preventing or suspending the use
of any preliminary or final prospectus or the initiation or threatening of any proceedings for such purposes, or any notification
with respect to the suspension of the qualification of the Registrable Securities for offering or sale in any jurisdiction or the
initiation or threatening of any proceeding for such purpose;


 


(h)        use
its reasonable efforts to prevent the issuance of any stop order suspending the effectiveness of any Registration Statement or
of any order preventing or suspending the use of any preliminary or final prospectus and, if any such order is issued, to obtain
the withdrawal of any such order as soon as practicable;


 


(i)        in
the case of an underwritten offering, make available for inspection, at the Company's headquarters during normal business hours,
by each Holder including Registrable Securities in such registration, any underwriter participating in any distribution pursuant
to such registration, and any attorney, accountant or other agent retained by such Holder or underwriter, all financial and other
records, pertinent corporate documents and properties of the Company, as such parties may reasonably request, and cause the Company’s
officers, directors and employees to supply all information reasonably requested by any such Holder, underwriter, attorney, accountant
or agent in connection with such Registration Statement;


 


(j)        use
its reasonable efforts to register or qualify, and cooperate with the Holders of Registrable Securities covered by such Registration
Statement, the underwriters, if any, and their respective counsel, in connection with the registration or qualification of such
Registrable Securities for offer and sale under the securities or “blue sky” laws of each state and other jurisdiction
of the United States as any such Holder or underwriters, if any, or their respective counsel reasonably request in writing, and
do any and all other things reasonably necessary or advisable to keep such registration or qualification in effect for such period
as required by Section 5.2(a), as applicable; provided that the Company shall not be required to qualify generally to do
business in any jurisdiction where it is not then so qualified or take any action which would subject it to taxation or general
service of process in any such jurisdiction where it is not then so subject;


 


(k)        in
the case of an underwritten offering, obtain for delivery to the underwriters, if any, an opinion or opinions from counsel for
the Company, dated the effective date of the Registration Statement or, in the event of an underwritten offering, the date of the
closing under the underwriting agreement, in customary form, scope and substance, which opinions shall be reasonably satisfactory
to such underwriters and their respective counsel;


 


(l)        in
the case of an underwritten offering, obtain for delivery to the Company and the underwriters, a cold comfort letter from the Company’s
independent certified public accountants in customary form and covering such matters of the type customarily covered by cold comfort
letters as managing underwriter or underwriters reasonably request, dated the date of execution of the underwriting agreement and
brought down to the closing under the underwriting agreement;


 


 


 



    24


     

    




(m)        use
its reasonable efforts to list the Registrable Securities covered by such Registration Statement with any securities exchange on
which the Common Stock is then listed;


 


(n)        provide
and cause to be maintained a transfer agent and registrar for all Registrable Securities covered by the applicable Registration
Statement from and after a date not later than the effective date of such Registration Statement;


 


(o)        cooperate
with Holders including Registrable Securities in such registration and the underwriters, if any, to facilitate the timely preparation
and delivery of certificates representing Registrable Securities to be sold, such certificates to be in such denominations and
registered in such names as such Holders or the managing underwriters may request at least two Business Days prior to any sale
of Registrable Securities; and


 


(p)        use
its reasonable efforts to comply with all applicable securities laws and make available to its Holders, as soon as reasonably practicable,
an earnings statement satisfying the provisions of Section 11(a) of the Securities Act and the rules and regulations promulgated
thereunder.


 


Section 5.6. Indemnification.


 


(a)        The
Company will, and does hereby undertake to, indemnify and hold harmless each Holder of Registrable Securities, each of such Holder’s
officers, directors, employees, partners and agents, and each Person controlling such Holder, with respect to any registration,
qualification or compliance effected pursuant to this Article V, and each underwriter, if any, and each Person who controls any
underwriter, of the Registrable Securities held by or issuable to such Holder, against all claims, losses, damages and liabilities
(or actions in respect thereto) to which they may become subject under the Securities Act, the Exchange Act, or other federal or
state law arising out of or based on (A) any untrue statement (or alleged untrue statement) of a material fact contained in any
prospectus, offering circular or other similar document (including any related Registration Statement, notification, or the like)
incident to any such registration, qualification or compliance, or based on any omission (or alleged omission) to state therein
a material fact required to be stated therein or necessary to make the statements therein not misleading in light of the circumstances
in which they were made, (B) any violation or alleged violation by the Company of any federal, state or common law rule or regulation
applicable to the Company in connection with any such registration, qualification or compliance, or (C) any failure to register
or qualify Registrable Securities in any state where the Company or its agents have affirmatively undertaken or agreed in writing
that the Company (the undertaking of any underwriter chosen by the Company being attributed to the Company) will undertake such
registration or qualification on behalf of the Holders of such Registrable Securities (provided that in such instance the
Company shall not be so liable if it has undertaken its reasonable efforts to so register or qualify such Registrable Securities)
and will reimburse, as incurred, each such Holder, each such underwriter and each such director, officer, partner, agent and controlling
person, for any legal and any other expenses reasonably incurred in connection with investigating or defending any such claim,
loss, damage, liability or action; provided that the Company will not be liable in any


 


 


 



    25


     

    




such case to the extent that any such claim, loss,
damage, liability or expense arises out of or is based on any untrue statement or omission made in reliance and in conformity with
written information furnished to the Company by such Holder or underwriter expressly for use therein.


 


(b)        Each
Holder will, and if Registrable Securities held by or issuable to such Holder are included in such registration, qualification
or compliance pursuant to this Article V, does hereby undertake to indemnify and hold harmless the Company, each of its directors,
employees, agents and officers, and each Person controlling the Company, each underwriter, if any, and each Person who controls
any underwriter, of the Company’s securities covered by such a Registration Statement, and each other Holder, each of such
other Holder’s officers, partners, directors and agents and each Person controlling such other Holder, against all claims,
losses, damages and liabilities (or actions in respect thereof) arising out of or based on any untrue statement (or alleged untrue
statement) of a material fact contained in any such Registration Statement, prospectus, offering circular or other document, or
any omission (or alleged omission) to state therein a material fact required to be stated therein or necessary to make the statements
therein not misleading in light of the circumstances in which they were made, and will reimburse, as incurred, the Company, each
such underwriter, each such other Holder, and each such director, officer, employee, agent, partner and controlling Person of the
foregoing, for any legal or any other expenses reasonably incurred in connection with investigating or defending any such claim,
loss, damage, liability or action, in each case to the extent, but only to the extent, that such untrue statement (or alleged untrue
statement) or omission (or alleged omission) was made in such Registration Statement, prospectus, offering circular or other document,
in reliance upon and in conformity with written information furnished to the Company by such Holder expressly for use therein;
provided, however, that the liability of each Holder hereunder shall be limited to the net proceeds received by such
Holder from the sale of securities under such Registration Statement. It is understood and agreed that the indemnification obligations
of each Holder pursuant to any underwriting agreement entered into in connection with any Registration Statement shall be limited
to the obligations contained in this subsection 5.6(b).


 


(c)        Each
party entitled to indemnification under this Section 5.6 (the “Indemnified Party”) shall give notice to the
party required to provide such indemnification (the “Indemnifying Party”) of any claim as to which indemnification
may be sought promptly after such Indemnified Party has actual knowledge thereof, and shall permit the Indemnifying Party to assume
the defense of any such claim or any litigation resulting therefrom; provided that counsel for the Indemnifying Party, who
shall conduct the defense of such claim or litigation, shall be subject to approval by the Indemnified Party (whose approval shall
not be unreasonably withheld) and the Indemnified Party may participate in such defense at the Indemnifying Party’s expense
if representation of such Indemnified Party would be inappropriate due to actual or potential differing interests between such
indemnified party and any other party represented by such counsel in such proceeding; and provided further that the failure
of any Indemnified Party to give notice as provided herein shall not relieve the Indemnifying Party of its obligations under this
Article V, except to the extent that such failure to give notice shall materially adversely affect the Indemnifying


 


 


 



    26


     

    




Party in the defense of any such claim or any such
litigation. An Indemnifying Party, in the defense of any such claim or litigation, may, without the consent of each Indemnified
Party, consent to entry of any judgment or enter into any settlement that includes as an unconditional term thereof the giving
by the claimant or plaintiff therein, to such Indemnified Party, of a release from all liability with respect to such claim or
litigation.


 


(d)        In
order to provide for just and equitable contribution in case indemnification is prohibited or limited by law, the Indemnifying
Party, in lieu of indemnifying such Indemnified Party, shall contribute to the amount paid or payable by such Indemnified Party
as a result of such losses, claims, damages or liabilities in such proportion as is appropriate to reflect the relative fault of
the Indemnifying Party and Indemnified Party in connection with the actions which resulted in such losses, claims, damages or liabilities,
as well as any other relevant equitable considerations. The relative fault of such Indemnifying Party and Indemnified Party shall
be determined by reference to, among other things, whether any action in question, including any untrue or alleged untrue statement
of material fact or omission or alleged omission to state a material fact, has been made by, or relates to information supplied
by, such Indemnifying Party or Indemnified Party, and such party’s relative intent, knowledge, access to information and
opportunity to correct or prevent such actions; provided, however, that, in any case, (i) no Holder will be required
to contribute any amount in excess of the public offering price of all securities offered by it pursuant to such Registration Statement
less all underwriting fees and discounts and (ii) no Person guilty of fraudulent misrepresentation (within the meaning of Section
11(f) of the Securities Act) will be entitled to contribution from any Person who was not guilty of such fraudulent misrepresentation.


 


Section 5.7. Information by Holder.
The Holder or Holders of Registrable Securities included in any registration shall furnish to the Company such information regarding
such Holder or Holders and the distribution proposed by such Holder or Holders as the Company may reasonably request in writing
and as shall be required in connection with any registration, qualification or compliance referred to in this Article V.


 


Section 5.8. Transfer of Registration
Rights. The rights, contained in Sections 5.2 and 5.3 hereof, to cause the Company to register the Registrable Securities,
may be assigned or otherwise conveyed by DSM pursuant to a transfer not prohibited by Section 3.2.


 


Section 5.9. Delay of Registration.
No Holder shall have any right to obtain or seek an injunction restraining or otherwise delaying any such registration as the result
of any controversy that might arise with respect to the interpretation or implementation of this Article V.


 


Section 5.10.Termination
of Registration Rights. In addition to any termination of this Agreement in accordance with Section 7.1 hereof, the rights
of DSM to cause the Company to register securities under Article V hereof shall terminate on the date when there no longer remaining
any Registrable Securities.


 






    27


     

    

ARTICLE VI


 


ADDITIONAL AGREEMENTS OF THE PARTIES


 


Section 6.1. Protective Provisions.
For so long as DSM is entitled to designate a director of the Board pursuant to Section 2.1(a)(i) of this Agreement, without the
affirmative vote of any then-serving DSM Director, the Company will not (and, where applicable, will not permit any of its Subsidiaries
to) (a) [*] or (b) other than principal and interest payments required by the terms of such agreement (as currently in effect),
use any proceeds from the transactions contemplated by the Prior Securities Purchase Agreement or the Securities Purchase Agreement
to repay any amounts owed by the Company under that certain Loan and Security Agreement, dated as of March 29, 2014, as amended
prior to the date hereof, between the Company and Stegodon Corporation (assignee of Hercules Technology Growth Capital, Inc.) prior
to the Term Loan Maturity Date (as such term is currently defined in such agreement).


 


Section 6.2. Right of
First Negotiation; Toll Manufacturing Option.


 


(a)
       The Company will not agree or commit to enter into any new agreements (or amend or otherwise
modify any existing agreement to cover any new project) with respect to any project in the [*] (the
“[*]”), including the projects set forth on Schedule 6.2(a) attached hereto,
unless the Company has first engaged in good faith negotiations with DSM with respect to such projects for a period of at least
sixty (60) days (the “Right of First Negotiation”); provided, however, that if DSM enters into a commercial
relationship with the Company with respect to any such project that obligates the Company to exclusively develop such project with
DSM, and following 24 months of the launch of such project the product development levels thereunder do not exceed volume thresholds
to be mutually agreed to by DSM and the Company within 90 days of the launch of such project, then the Company will be released
from its exclusivity obligations under such commercial relationship with DSM but the Company shall otherwise remain bound by its
other obligations thereunder. 


 


(b)
       DSM will also have an option (the “Toll Manufacturing Option”) to
use the Brotas 1 or Brotas 2 facility for toll manufacturing of DSM [*] and / or other DSM
products by the Company; provided, however, that (i) such option shall be limited to [*] of the manufacturing capacity of each
such facility, (ii) (a) with respect to Brotas 1, any such products manufactured for DSM must have a higher return to the Company
relative to any alternative projects at Brotas 1 related to the manufacture, distribution, license, sale, transfer or assignment
of [*] available to the Company, as determined in good faith by the Board, and (b) with
respect to Brotas 2, any such products manufactured for DSM must have a higher return to the Company relative to any alternative
projects at Brotas 2 available to the Company, as determined in good faith by the Board. 


 


 


 


 


 


[*] Certain portions denoted with an asterisk have been omitted
and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions.




 



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(c)        Notwithstanding
the foregoing, (i) the Toll Manufacturing Option set forth in Section 6.2(b) shall expire if the aggregate annual cash spend by
DSM (calculated for each calendar year beginning on January 1, 2018) in favor of the Company in connection with all commercial
activity with the Company, including payments for production of DSM products, license fees, exclusivity payments and/or collaboration
payments for joint development programs, is less than [*], and (ii) the Toll Manufacturing Option set forth in Section 6.2(b) shall
not be exercisable by DSM if there are no active projects with DSM at Brotas 1 or Brotas 2 following the date that is 36 months
after the Closing.


 


Section 6.3. Further Assurances; Operational
Cost Savings. From time to time, at the reasonable request of any other party hereto and without further consideration, each
party hereto shall execute and deliver such additional documents and take all such further action as may be necessary or appropriate
to consummate and make effective, in the most expeditious manner practicable, the transactions contemplated by this Agreement.
The Company will use reasonable best efforts to implement operational cost/expense savings of at least [*] per annum beginning
on January 1, 2018.


 


Section 6.4. Tranche II Funding.
As of the Closing, the Company hereby acknowledges that the [*] License Agreement described in clause (i) of the definition of
IP License set forth in the Prior Securities Purchase Agreement shall become effective. During the 90-day period following the
Closing (the end of such period, the “Outside Date”), DSM and the Company will in good faith negotiate to mutually
agree on the most critical (operational) parameters for the development of the molecule best suited to achieve the cost targets
defined for [*], including the best molecular biotech intermediate taking into account an adequate subsequent chemical route for
DSM, development costs (which shall be limited to direct costs only), production costs and corresponding value share between the
Company and DSM; it being the intention and desire of the parties that (a) DSM will achieve a per unit cost that is at least [*],
or as otherwise mutually agreed by the Company and DSM, and (b) from and after May 11, 2017, DSM will be charged only for the Company’s
direct costs for development work for the [*] collaboration, provided that the collaboration terms include a value sharing arrangement
for the manufacturing of [*] by the Company for DSM. In the event that the parties do not reach agreement on such parameters prior
to the Outside Date, (i) the Right of First Negotiation set forth in Section 6.2(a) shall terminate and expire with respect to
[*] only, (ii) on the first anniversary of the Closing and each subsequent anniversary thereof, the Company will make a [*] cash
payment to DSM by wire transfer of immediately available funds to a bank account designated by DSM in writing at least two (2)
Business Days prior to each such payment date; provided that the aggregate amount of such payments shall not exceed the Tranche
II Funding Amount and (iii) the Intellectual Property Escrow Agreement described in clause (ii) of the definition of IP License
set forth in the Prior Securities Purchase Agreement shall become effective. Following the Closing, DSM and the Company will in
good faith negotiate a development agreement regarding each of the products listed on Schedule 6.2(a) other than [*], it being
the intention of the parties that (A) DSM will achieve a per unit cost for such product that is competitive, but at least [*] for
such product, or as otherwise mutually agreed by the Company and DSM, and (B) DSM will be charged only for the


 


[*] Certain portions denoted with an asterisk have been omitted
and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions.




 



    29


     

    




Company’s direct costs for development work for such product,
provided that the collaboration terms include a value sharing arrangement for the manufacturing of any product under such collaboration
by the Company for DSM. For the avoidance of doubt the prior sentence does not create an obligation to enter into a development
agreement regarding the products listed on Schedule 6.2(a) other than [*], but rather creates an obligation to negotiate in good
faith with respect to any such agreement.


 


ARTICLE VII


 


TERMINATION 


 


Section 7.1. Termination. This
Agreement shall terminate and be of no further force and effect upon and after the Company’s consummation of a Change of
Control; provided, however, that (i) such termination shall not waive or release any party from any liability for such party’s
willful breach of this Agreement occurring prior to such termination and (ii) Section 6.2 (and, with respect thereto, Articles
I and VIII) shall survive such termination and remain in full force and effect following such termination.


 


ARTICLE VIII 


 


MISCELLANEOUS 


 


Section 8.1. Entire Agreement.
This Agreement (together with the Prior Securities Purchase Agreement, the Securities Purchase Agreement, the Warrants, the IP
License (as such term is defined in the Prior Securities Purchase Agreement) and the Company’s Certificate of Designation
of Preferences, Rights and Limitations of Series B 17.38% Convertible Preferred Stock) constitutes the entire understanding and
agreement between the parties as to the matters covered herein and supersedes and replaces any prior understanding, agreement or
statement of intent, in each case, written or oral, of any and every nature with respect thereto.


 


Section 8.2. Specific Performance.
The parties hereto agree that the obligations imposed on them in this Agreement are special, unique and of an extraordinary character,
and that, in the event of breach or threatened breach by any party, damages would not be an adequate remedy and each of the other
parties shall be entitled to specific performance and injunctive and other equitable relief in addition to any other remedy to
which it may be entitled, at law or in equity; and the parties hereto further agree to waive any requirement for the securing or
posting of any bond in connection with the obtaining of any such injunctive or other equitable relief.


 


Section 8.3. Governing
Law. This Agreement shall be governed by and construed in accordance with the laws of the State of New York applicable to contracts
entered into and performed entirely within such state, without regard to conflict of laws principles.


 


Section 8.4. Amendment and Waiver.


 


 


 


[*] Certain portions denoted with an asterisk
have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with
respect to the omitted portions.


 


 


 



    30


     

    




(a)        This
Agreement may be amended or modified, and any provision hereof may be waived, in whole or in part, at any time pursuant to an agreement
in writing executed by the Company and DSM.


 


(b)        Any
failure by any party at any time to enforce any of the provisions of this Agreement shall not be construed a waiver of such provision
or any other provisions hereof.


 


Section 8.5. Binding Effect.
Except as otherwise expressly provided herein, the provisions hereof shall inure to the benefit of, and be binding upon, the parties’
successors and permitted assigns.


 


Section 8.6. Notices. Any and
all notices or other communications or deliveries required or permitted to be provided hereunder shall be in writing and shall
be deemed given and effective on the earliest of (a) the date of transmission, if such notice or communication is delivered via
facsimile or email at the facsimile number or email address specified in this Section prior to 6:30 p.m. (Pacific Time) on a Business
Day, (b) the next Business Day after the date of transmission, if such notice or communication is delivered via facsimile or email
at the facsimile number or email address specified in this Section on a day that is not a Business Day or later than 6:30 p.m.
(Pacific Time) on any Business Day, (c) the Business Day following the date of deposit with a nationally recognized overnight courier
service, or (d) upon actual receipt by the party to whom such notice is required to be given. The addresses, facsimile numbers
and email addresses for such notices and communications are those set forth on the signature pages hereof, or such other address
or facsimile number as may be designated in writing hereafter, in the same manner, by any such Person.


 


Section 8.7. Severability.
If any portion of this Agreement shall be declared void or unenforceable by any court or administrative body of competent jurisdiction,
such portion shall be deemed severable from the remainder of this Agreement, which shall continue in all respects valid and enforceable.


 


Section 8.8. Counterparts.
This Agreement may be executed in any number of counterparts, each of which shall be deemed an original, but all of which together
shall constitute a single instrument.


 


Section 8.9. Prior Agreement.
Pursuant to Section 8.4(a) of the Prior Agreement, effective and contingent upon execution of this Agreement by the Company and
DSM, the Prior Agreement is hereby amended and restated in its entirety to read as set forth in this Agreement, and the Company
and DSM shall be bound by the provisions hereof.


 


[The remainder of this page intentionally left
blank]


 


 


 



    31


     

    




IN WITNESS WHEREOF, each of the undersigned
has executed this Agreement or caused this Agreement to be executed on its behalf as of the date first written above.



 



	 	AMYRIS, INC.
	 	 	 	 
	 	By:	/s/ John Melo
	 	 	Name	John Melo
	 	 	Title:	President and CEO
	 	 	 	 
	 	Address for Notice:
	 	 	 	 
	 	 	5885 Hollis Street, Suite 100
	 	 	Emeryville, CA  94608
	 	 	 	 
	 	Facsimile No.:	 
	 	 	 	 
	 	Email Address:
	 	 	 	 
	 	 	 	 
	 	Attn:	General Counsel
	 	 	 	 
	 	with a copy (which shall not constitute
	 	notice) to:
	 	 	 	 
	 	Fenwick & West LLP
	 	801 California Street
	 	Mountain View, CA 94110
	 	Attention:
	 	Email Address:



 


 



 


 


 






     


     

    

IN WITNESS WHEREOF, each of the undersigned
has executed this Agreement or caused this Agreement to be executed on its behalf as of the date first written above.


 


 


 


	 	DSM International B.V.
	 	 	 	 
	 	By:	/s/ Hugh Welsh
	 	 	Name	Hugh Welsh
	 	 	Title:	President DSM NA
	 	 	 	 
	 	By:	 	 
	 	 	Name	 
	 	 	Title:	 
	 	 	 	 
	 	Address for Notice:	6411 TE Herleen,

the Netherlands
	 	 	 	 
	 	Attention:	General Counsel
	 	 	 	 
	 	Facsimile No.:	 
	 	 	 	 
	 	Email Address:
	 	 	 	 
	 	with a copy (which shall not constitute
	 	notice) to:
	 	 	 	 
	 	Latham & Watkins LLP
	 	330 North Wabash Ave, Suite 2800
	 	Chicago, Illinois 60611
	 	Attention:
	 	 
	 	Email Address:


 


 


 


 


 


 






     


     

    

Exhibit A


 


List of Competitors


 


[*]


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


[*] Certain portions denoted with an asterisk
have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with
respect to the omitted portions.


 


 


 






     


     

    

Schedule 6.2(a)


 


Subject to those pre-existing commercial arrangements described
below, as in effect as of the date hereof, projects relating to [*].


 


Pre-existing commercial arrangements: The Company
has pre-existing commercial arrangements with (i) [*] and (ii) [*].


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


[*] Certain portions denoted with an asterisk
have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with
respect to the omitted portions.