SECURITIES
PURCHASE AGREEMENT


 


THIS
SECURITIES PURCHASE AGREEMENT (the “Agreement”) is entered into as of this _________ day of November, 2017 (the “Effective
Date”) between the parties on the signature page to this Agreement (each, a “Purchaser”), and Cocrystal Pharma,
Inc., a Delaware corporation (“COCP”) (collectively, the Purchaser and COCP are the “Parties”).


 


WHEREAS,
this Agreement contemplates a transaction in which the Purchaser will purchase from COCP, and COCP will sell to the Purchaser,
up to $2 million of Promissory Notes (the “Notes”) convertible into COCP common stock on the terms contained in the
form of Note attached as Exhibit A;


 


NOW,
THEREFORE, in consideration of the mutual promises contained herein, and for good and valuable consideration, the receipt and
sufficiency of which is hereby acknowledged, the Parties hereto agree as follows:


 


1.
Sale and Purchase. COCP agrees to sell and the Purchaser agrees to purchase a Note from the Company in the amount
of $________ and the Company shall issue such Note to the Purchaser. The Note shall be convertible into COCP common stock at $0.27
per share; provided, however, if COCP closes on a financing in which it receives at least $10 million in gross proceeds
and issues common stock or common stock equivalents to the investors (a “Financing”), the conversion price shall be
the lesser of: (i) $0.27 per share and (ii) the price per share of common stock sold in the Financing, and the Note shall automatically
be converted. All funds shall be wired to COCP in accordance with Exhibit B.


 


2.
Representations and Warranties of COCP. As an inducement to the Purchaser to enter into this Agreement and consummate
the transaction contemplated hereby, COCP hereby makes the following representations and warranties, each of which is materially
true and correct on the date hereof:


 


2.1
Organization. COCP is a corporation duly organized, validly existing, and in good standing under the laws of the State
of Delaware and is duly authorized to conduct business as currently conducted.


 


2.2
Authority. COCP has full power and authority to execute and deliver this Agreement and to perform its obligations hereunder.
This Agreement constitutes the valid and legally binding obligation of COCP, enforceable in accordance with its terms. The execution,
delivery, and performance of this Agreement and all other agreements contemplated hereby have been duly authorized by COCP.


 


2.3
Non-Contravention. The execution and delivery of this Agreement by COCP and the observance and performance of the terms
and provisions contained herein do not constitute a violation or breach of any applicable law, or any provision of any other contract
or instrument to which COCP is a party or by which it is bound, or any order, writ, injunction, decree, statute, rule, by-law
or regulation applicable to COCP.


 




    	 



    	 



    

 





2.4
Litigation. There are no actions, suits, or proceedings pending or, to the best of COCP’s knowledge, threatened,
which could in any manner restrain or prevent COCP from effectually and legally entering into this Agreement. COCP is not a party
to any litigation except as has been disclosed in its filings with the Securities and Exchange Commission (the “SEC”).


 


2.5
Brokers’ Fees. COCP has no liability or obligation to pay fees or commissions to any broker, finder, or agent with
respect to the transactions contemplated by this Agreement.


 


2.6
Reporting Company. COCP is a publicly-held company subject to reporting obligations pursuant to Section 13 of the Securities
Exchange Act of 1934 (the “Exchange Act”) and has a class of common stock registered pursuant to Section 12(g) of
the Exchange Act.


 


2.7
SEC Reports. COCP has filed with the SEC all reports required to be filed since January 1, 2015, none of the reports filed
with the SEC contained any material statements which were not true and correct or omitted to state any statements of material
fact necessary in order to make the statements made not misleading.


 


2.8
Outstanding Securities. All issued and outstanding shares of capital stock and equity interests in COCP have been duly
authorized and validly issued and are fully paid and non-assessable.


 


3.
Representations and Warranties of the Purchaser. As an inducement to COCP to enter into this Agreement and to consummate
the transactions contemplated hereby, the Purchaser hereby makes the following representations and warranties, each of which is
materially true and correct on the date hereof and will be materially true and correct on the closing date:


 


3.1
Authority. The Purchaser has full power and authority to execute and deliver this Agreement and to perform its obligations
hereunder. This Agreement constitutes the valid and legally binding obligation of the Purchaser, enforceable in accordance with
its terms. The execution, delivery, and performance of this Agreement and all other agreements contemplated hereby have been duly
authorized by the Purchaser.


 


3.2
Non-Contravention. The execution and delivery of this Agreement by the Purchaser and the observance and performance of
the terms and provisions of this Agreement on the part of the Purchaser to be observed and performed will not constitute a violation
of applicable law or any provision of any contract or other instrument to which the Purchaser is a party or by which it is bound,
or any order, writ, injunction, decree statute, rule or regulation applicable to it.


 


3.3
Litigation There are no actions, suits, or proceedings pending or, to the best of the Purchaser’s knowledge, threatened,
which could in any manner restrain or prevent the Purchaser from effectually and legally purchasing the Notes pursuant to the
terms and provisions of this Agreement.


 




    	 



    	 



    

 


3.4
Brokers’ Fees. The Purchaser has no liability or obligation to pay fees or commissions to any broker, finder, or
agent with respect to the transactions contemplated by this Agreement.


 


3.5
Information. The Purchaser has relied solely on the reports of COCP filed with the SEC, other publicly available information
and other written and electronic information prepared by COCP in making its decision to purchase the Notes. The Purchaser acknowledges
that the purchase of the Notes entails a high degree of risk including the risks highlighted in the risk factors contained in
filings by COCP with the SEC including its annual report on Form 10-K for the year ended December 31, 2016. The Purchaser represents
that it has had an opportunity to ask questions and receive answers from COCP regarding the terms and conditions of this Agreement
and the reasons for this offering, the business prospects of COCP, the risks attendant to COCP’s business, and the risks
relating to an investment in COCP. The Purchaser acknowledges the receipt (without exhibits) of or access to the reports filed
with SEC at www.sec.gov which includes COCP’s reports referred to in this Section 3.5.


 


3.6
Investment. The Purchaser is acquiring the Notes for its own account for investment and not with a view to, or for sale
in connection with, any distribution thereof, nor with any present intention of distribution or selling the same, and, except
as contemplated by this Agreement, and has no present or contemplated agreement, undertaking, arrangement, obligation, indebtedness
or commitment providing for the disposition thereof. The Purchaser understands that the Notes may not be sold, transferred or
otherwise disposed of without registration under the Act or an exemption therefrom, and that in the absence of an effective registration
statement covering the Notes or an available exemption from registration under the Act, the Notes must be held indefinitely.


 


3.7
Restricted Securities. The Purchaser understands that the Notes have not been registered under the Act in reliance on an
exemption from registration under the Securities Act of 1933 (the “Act”) pursuant to Section 4(a)(2) thereof and Rule
506(b) thereunder and the Notes will bear a restrictive legend.


 


3.8
Investment Experience. The Purchaser represents that it is an “accredited investor” within the meaning of the
applicable rules and regulations promulgated under the Act, for one of the reasons on the attached Exhibit C to this Agreement.
The Purchaser represents and acknowledges that (i) it is experienced in evaluating and investing in private placement transactions
in similar circumstances, (ii) it has such knowledge and experience in financial and business matters and is capable of evaluating
the merits and risks of the investment in the Notes, (iii) it is able to bear the substantial economic risks of an investment
the Notes for an indefinite period of time, (iv) it has no need for liquidity in such investment, (v) it can afford a complete
loss of such investment, and (vi) it has such knowledge and experience in financial, tax and business matters so as to enable
it to utilize the information made available to it in connection with the offering of the Notes to evaluate the merits and risks
of the purchase of the Notes and to make an informed investment decision with respect thereto.


 




    	 



    	 



    

 


3.9
No General Solicitation. The offer to sell the Notes was directly communicated to the Purchaser by COCP. At no time was
the Purchaser presented with or solicited advertisement, articles, notice or other communication published in any newspaper, television
or radio or presented at any seminar or meeting, or any solicitation by a person not previously known to the undersigned in connection
with the communicated offer.


 


4.
Survival of Representations and Warranties and Agreements. All representations and warranties of the Parties contained
in this Agreement shall survive the closing.


 


5.
Indemnification.


 


5.1
Indemnification Provisions for Benefit of the Purchaser. In the event COCP breaches any of its representations, warranties,
and/or covenants contained herein, and provided that the Purchaser makes a written claim for indemnification against COCP, then
COCP agrees to indemnify the Purchaser from and against the entirety of any losses, damages, amounts paid in settlement of any
claim or action, expenses, or fees including court costs and reasonable attorneys’ fees and expenses.


 


5.2
Indemnification Provisions for Benefit of COCP. In the event the Purchaser breaches any of its representations, warranties,
and/or covenants contained herein, and provided that COCP makes a written claim for indemnification against the Purchaser, then
the Purchaser agrees to indemnify COCP from and against the entirety of any losses, damages, amounts paid in settlement of any
claim or action, expenses, or fees including court costs and reasonable attorneys’ fees and expenses.


 


6.
Post-Closing Covenants. The Parties agree as follows with respect to the period following the closing:


 


6.1
General. In case at any time after the closing any further action is necessary or desirable to carry out the purposes of
this Agreement, each of the Parties will take such further action (including the execution and delivery of such further instruments
and documents) as the other Party may request, all at the sole cost and expense of the requesting Party (unless the requesting
Party is entitled to indemnification therefore under Section 5).


 


6.2
Company. COCP hereby covenants that, after the closing, COCP will, at the request of Purchaser, execute, acknowledge and
deliver to the Purchaser without further consideration, all such further assignments, conveyances, consents and other documents,
and take such other action, as the Purchaser may reasonably request (a) to transfer to, vest and protect in the Purchaser and
its right, title and interest in the Notes, and (b) otherwise to consummate or effectuate the transactions contemplated by this
Agreement.


 


7.
Expenses. Except as otherwise provided in this Agreement, all Parties hereto shall pay their own expenses, including
legal and accounting fees, in connection with the transactions contemplated herein.


 


8.
Severability. In the event any parts of this Agreement are found to be void, the remaining provisions of this Agreement
shall nevertheless be binding with the same effect as though the void parts were deleted.


 




    	 



    	 



    

 


9.
Counterparts. This Agreement may be executed in one or more counterparts, each of which shall be deemed an original
but all of which together shall constitute one and the same instrument. The execution of this Agreement may be by actual or facsimile
signature.


 


10.
Benefit. This Agreement shall be binding upon and inure to the benefit of the parties hereto and their legal representatives,
successors and assigns. Nothing in this Agreement, expressed or implied, is intended to confer on any person other than the Parties
or their respective heirs, successors and assigns any rights, remedies, obligations, or other liabilities under or by reason of
this Agreement.


 


11.
Notices and Addresses. All notices, offers, acceptance and any other acts under this Agreement (except payment)
shall be in writing, and shall be sufficiently given if delivered to the addressees in person, by FedEx or similar overnight next
business day delivery, or by email followed by overnight next business day delivery, as follows:


 


	To
    COCP:	Cocrystal
    Pharma, Inc.
	 	1860
    Montreal Road
	 	Tucker,
    Georgia 30084
	 	Attention:
     Dr. Gary Wilcox
	 	Email:
     gwilcox@cocrystalpharma.com
	 	 
	To
    the Purchaser:	The
    address set forth on the signature page attached hereto


 


or
to such other address as any of them, by notice to the other may designate from time to time.


 


12.
Attorney’s Fees. In the event that there is any controversy or claim arising out of or relating to this Agreement,
or to the interpretation, breach or enforcement thereof, and any action or arbitration proceeding is commenced to enforce the
provisions of this Agreement, the prevailing party shall be entitled to a reasonable attorney’s fee, including the fees
on appeal, costs and expenses.


 


13.
Governing Law. This Agreement and any dispute, disagreement, or issue of construction or interpretation arising
hereunder whether relating to its execution, its validity, the obligations provided therein or performance shall be governed or
interpreted according to the laws of the State of Delaware.


 


14.
Oral Evidence. This Agreement constitutes the entire Agreement between the parties and supersedes all prior oral
and written agreements between the parties hereto with respect to the subject matter hereof. Neither this Agreement nor any provision
hereof may be changed, waived, discharged or terminated orally, except by a statement in writing signed by the party or parties
against whom enforcement or the change, waiver discharge or termination is sought.


 


15.
Assignment. No Party hereto shall assign its rights or obligations under this Agreement without the prior
written consent of the other Party.


 




    	 



    	 



    

 


16.
Section Headings. Section headings herein have been inserted for reference only and shall not be deemed to limit
or otherwise affect, in any matter, or be deemed to interpret in whole or in part any of the terms or provisions of this Agreement.


 


FLORIDA
LAW PROVIDES THAT WHEN SALES ARE MADE TO FIVE OR MORE PERSONS IN FLORIDA, ANY SALE MADE IN FLORIDA IS VOIDABLE BY THE PURCHASER
WITHIN THREE DAYS AFTER THE FIRST TENDER OF CONSIDERATION IS MADE BY SUCH PURCHASER TO COCP, AN AGENT OF COCP OR AN ESCROW AGENT
OR WITHIN THREE DAYS AFTER THE AVAILABILITY OF THAT PRIVILEGE IS COMMUNICATED TO SUCH PURCHASER, WHICHEVER OCCURS LATER. PAYMENTS
FOR TERMINATED SUBSCRIPTIONS VOIDED BY PURCHASERS AS PROVIDED FOR IN THIS PARAGRAPH WILL BE PROMPTLY REFUNDED WITHOUT INTEREST.
NOTICE SHOULD BE GIVEN TO COCP AT THE ADDRESS SET FORTH IN SECTION 11 OF THIS AGREEMENT. 


 


[Signature
Page Attached]


 




    	 



    	 



    

 


IN
WITNESS WHEREOF the parties hereto have set their hand and seals as of the above date.


 


	 	COCRYSTAL
    PHARMA, INC.:
	 	 	 
	 	By:
    	 
	 	 	Gary
    Wilcox,
	 	 	Interim
    Chief Executive Officer


 


	 	PURCHASER:

         

	 	By: 	                  
	 	(Print
                                         Name and Title)

        



 


	 	Address:	 
	 	 	 





	 	 


 


	 	Email:	 


 


	 	Tax
    ID of Purchaser: 	 


 


Amount
Invested: $__________________.


 




    	 



    	 



    

 


Exhibit
A


 


[FORM
OF NOTE]


 




    	 



    	 



    

 


Exhibit
B


(Cocrystal
Wire Instructions)


 




    	 



    	 



    

 





Exhibit
C


 


Accredited
Investor Questionnaire


 


For
Individual Investors Only:


 


(1)
I am an accredited investor because I have an individual net worth, or my spouse and I have combined net worth, in excess of $1,000,000.
For purposes of calculating net worth under this paragraph (1), (i) the primary residence shall not be included as an asset, (ii)
to the extent that the indebtedness that is secured by the primary residence is in excess of the fair market value of the primary
residence, the excess amount shall be included as a liability, and (iii) if the amount of outstanding indebtedness that is secured
by the primary residence exceeds the amount outstanding 60 days prior to the execution of this Securities Purchase Agreement,
other than as a result of the acquisition of the primary residence, the amount of such excess shall be included as a liability.


 


(2a)
I am an accredited investor because I had individual income (exclusive of any income attributable to my spouse) of more than $200,000
in the last two completed years and I reasonably expect to have an individual income in excess of $200,000 this year.


 


(2b)
Alternatively, my spouse and I have joint income in excess of $300,000 in each applicable year.


 


(3)
I am a director or executive officer of the Company.


 


Other
Investors:


 


(4)
The undersigned is one of the following: any bank as defined in Section 3(a)(2) of the Securities Act whether acting in its individual
or fiduciary capacity; any broker or dealer registered pursuant to section 15 of the Securities Exchange Act of 1934; insurance
company as defined in Section 2(13) of the Securities Act; investment company registered under the Investment Company Act of 1940
or a business development company as defined in Section 2(a)(48) of that Act; Small Business Investment Company licensed by the
U.S. Small Business Administration under Section 301(c) or (d) of the Small Business Investment Act of 1958; any plan established
and maintained by a state, its political subdivisions, or any agency or instrumentality of a state or its political subdivisions,
for the benefit of its employees, if such plan has total assets in excess of $5,000,000; employee benefit plan within the meaning
of Title I of the Employee Retirement Income Security Act of 1974, if the investment decision is made by a plan fiduciary, as
defined in Section 3(21) of such Act, which is either a bank, savings and loan association, insurance company, or registered investment
advisor, or if the employee benefit plan has total assets in excess of $5,000,000, or if a self-directed plan, with investment
decisions made solely by persons that are accredited investors.


 


(5)
The undersigned is a private business development company as defined in Section 202(a)(22) of the Investment Advisors Act of 1940.


 


(6)
The undersigned is a organization described in Section 501(c)(3) of the Internal Revenue Code, corporation, Massachusetts or similar
business trust or partnership, not formed for the specific purpose of acquiring the securities offered, with total assets in excess
of $5,000,000.


 


(7)
The undersigned is a trust, with total assets in excess of $5,000,000, not formed for the specific purpose of acquiring the securities
offered, whose purchase is directed by a sophisticated person as described in Rule 506(b)(2)(ii) of the Securities Act.


 


(8)
The undersigned is an entity in which all of the equity owners are accredited investors.