Initial to indicate certification as to information on this page

(full text of certification is on page one).

Date

INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. 

Use additional sheet(s) if necessary.

2. Case # and Name 3. Date and Type of DCI and Number

4. EPA Product 

Registration

5. I wish to cancel 

this product 

registration 

voluntarily

6. Generic Data 7. Product Specific Data

6a. I am claiming a Generic Data 

Exemption because I obtain the 

active ingredient from the source 

EPA registration number listed 

below.

6b. I agree to satisfy Generic Data

Requirements as indicated on the 

attached form entitled 

"Requirements Status and 

Registrant's Response."

7a. My product is an MUP and I 

agree to satisfy the MUP 

requirement on the attached form

entitled "Requirements Status and

Registrant's Response."

7b. My product is an EUP and I 

agree to satisfy the EUP 

requirement on the attached form 

entitled "Requirements Status and 

Registrant's Response."

OMB Approval 2070-0174

1. Company Name and Address

N/A - Isoxaben

Chemical # and Name: 125851

Isoxaben

18-Feb-2010

GENERIC

ID # GDCI-125851-965

United States Environmental Protection Agency

Washington, D.C. 20460

DATA CALL-IN RESPONSE

Page of 1 1

8. Certification: I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any

knowingly false or misleading statement may be punishable by fine, imprisonment or both under applicable law.

Signature and Title of Company's Authorized Representative ______________________________________________________

10. Name of Company

N/A N/A

9. Date

11. Phone Number 
Initial to indicate certification as to information on this page (full text of certification is on page one) 

13. Phone Number

10. Certification: I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any 

knowingly false or misleading statement may be punishable by fine, imprisonment or both under applicable law.

12. Name of Company

11. Date

OMB Approval 2070-0174

United States Environmental Protection Agency 

Washington, D.C. 20460

REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE

INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline

Requirement

Number

5. Study Title Progress 

Reports

1 2 3

6. Use 

Pattern

7. Test 

Substance

8. Time

Frame 

(Months)

9. Registrant

Response

P

R

O

T

O

C

O

L

1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

Signature and Title of Company's Authorized Representative _________________________________________________________________

Environmental Fate Data Requirements (Conventional 

Chemical)

Nontarget Plant Protection Data Requirements (Conventional 

Chemical)

Product Chemistry Data Requirements (Conventional 

Chemical)

835.2410

850.4225

850.4250

850.4400

830.7050

Photodegradation of parent and degradates in soil

Seedling emergence, Tier II

Vegetative vigor, Tier II

Aquatic plant toxicity test using Lemna spp. Tiers I 

and II

UV/Visible absorption

N/A - Isoxaben

Chemical # and Name: 125851

Isoxaben

18-Feb-2010

GENERIC

ID # GDCI-125851-965

J,C,Q,II

J,C,Q,II

J,C,Q,II

J,C,Q,II

J,C,Q,II

EP; PAI; TGAI

TEP

TEP

EP; PAI; TGAI

EP; PAI; TGAI

12

12

12

12

8

Page 1 of 

(3)

(4)

N

N

N

N

N

2
Date

OMB Approval 2070-0174

United States Environmental Protection Agency 

Washington, D.C. 20460

REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE

INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline

Requirement

Number

5. Study Title Progress 

Reports

1 2 3

6. Use 

Pattern

7. Test 

Substance

8. Time

Frame 

(Months)

9. Registrant

Response

P

R

O

T

O

C

O

L

1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

Toxicology Data Requirements (Conventional Chemical)

870.3465

870.6200

870.7800

90-day inhalation toxicity

Neurotoxicity screening battery

Immunotoxicity

N/A - Isoxaben

Chemical # and Name: 125851

Isoxaben

18-Feb-2010

GENERIC

ID # GDCI-125851-965

J,C,Q,II

J,C,Q,II

J,C,Q,II

TGAI

TGAI

TGAI

24

24

0

Page 2 of 

(2, 5)

(1, 6, 7)

N

N

Y

2
United States Environmental Protection Agency 

Washington, D.C. 20460

FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS

N/A - Isoxaben

GDCI-125851-965

1

2

3

4

5

6

7

Key: Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active 

Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

The timeframe for completing the acute neurotoxicity screening study is 12 months.

Required if there is the likelihood of significant repeated inhalation exposure to the pesticide as a gas, vapor, or aerosol.

Required if a terrestrial species exhibits a 25 percent or greater detrimental effect in Tier 1. Test species should be the one that exhibited detrimental effects in Tier 1 testing.

Required if a terrestrial species exhibits a 25 percent or greater detrimental effect in Tier 1. Test species should be the species that showed detrimental effects in the Tier I testing.

Based on estimates of the magnitude and duration of human exposure, studies of shorter duration, e.g., 21 or 28-days, may be sufficient to satisfy this requirement. Registrants should consult 

with the Agency to determine whether studies of shorter duration would meet this requirement.

All 90-day subchronic studies in rats can be designed to simultaneously fulfill the requirements of the 90-day neurotoxicity study using separate groups of animals for testing. Although the 

subchronic guidelines include the measurement of neurological endpoints, they do not meet the requirement of the 90-day neurotoxicity study (guideline 870.6200).

Additional measurements such as cholinesterase activity for certain pesticides, e.g., organophosphates and some carbamates, will also be required. The route of exposure must correspond 

with the primary route of exposure.

Case # and Name:

DCI Number:

Page: 1 of 1

Footnotes: The following footnotes are referenced in column two (5. Study Title) of the Requirements Status and Registrant's Response form. 

These footnotes apply in addition to any test notes included in 40 CFR Part 158 with respect to the particular data requirement.

Use Categories Key:

C - Terrestrial nonfood crop

J - Forestry use

Q - Residential outdoor use

II - Residential Use Conventional Chemical
United States Environmental Protection Agency 

Washington, D.C. 20460

LIST OF ALL REGISTRANTS SENT THIS DATA CALL-IN NOTICE

Case # and Name: N/A - Isoxaben

Page: 1 of 1

83558

62719

CELSIUS PROPERTY B.V., AMSTERDAM 

(NL) 

DOW AGROSCIENCES LLC

Co. Nr. Company Name Agent For Company

MAKHTESHIM AGAN OF NORTH 

AMERICA, INC.

3120 HIGHWOODS BLVD., SUITE 100

9330 ZIONSVILLE RD 308/2E

Address City ZIP

RALEIGH

INDIANAPOLIS

27604 

462681054

OMB Approval 2070-0174

State

NC

IN

 DCI Number: GDCI-125851-965
LINKS TO FORMS:

The pesticide registration forms that are listed below can be found at:

http://www.epa.gov/opprd001/forms/

Link to Confidential Statement of Formula and Instructions (Form # 8570-4)

http://www.epa.gov/opprd001/forms/8570-4.pdf

Certification of Attempt to Enter Into an Agreement With Registrants for 

Development of Data (Form # 8570-32)

http://www.epa.gov/opprd001/forms/8570-32.pdf

Certification With Respect to Citation of Data (Form # 8570-34)

http://www.epa.gov/opprd001/forms/8570-34.pdf