Mefenpyr-diethyl Dietary Exposure and Risk Assessment

PC Code: 811800

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

MEMORANDUM

Date: February 22, 2011

SUBJECT: Mefenpyr-diethyl (HOE 107892) Safener

Dietary (Food and Drinking Water)

Section 3 Registration Action

on Sorghum and Grasses Grown for Seed

PC Code: 811800

Decision No.: 425581

Petition No.: PP#9F7679

Risk Assessment Type: Dietary

TXR No.: NA

MRID No.: NA

FROM: Alexandra LaMay, Biologist

Risk Assessment Branch VII

Health Effects Division (7509P)

THROUGH: Meheret Negussie

Sheila Piper, Chemist

Dietary Exposure Science Advisory Council (DESAC)

Health Effects Division (7509P)

and

Michael S. Metzger, Chief

Risk Assessment Branch VII

Health Effects Division (7509P)

TO: Bethany Benbow

Herbicide Branch

Registration D

Dietary Exposure and Risk Assessment D

Page 1 of 12

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460 

OFFICE OF CHEMICAL SAFETY

AND POLLUTION PREVENTION

, 2011

diethyl (HOE 107892) Safener Revised Chronic Aggregate

ood and Drinking Water) Exposure and Risk Assessment for the 

Registration Action to Add New Uses and Establish Tolerances

on Sorghum and Grasses Grown for Seed.

DP Barcode: 380767

Registration No.: NA

Regulatory Action: Section 3

Dietary Case No.: NA

CAS No.: 135590-91-9

40 CFR: 180.509

Alexandra LaMay, Biologist

Risk Assessment Branch VII

Health Effects Division (7509P)

Meheret Negussie, Chemist

, Chemist

Dietary Exposure Science Advisory Council (DESAC)

Effects Division (7509P)

Michael S. Metzger, Chief

Risk Assessment Branch VII

Health Effects Division (7509P)

Bethany Benbow

Herbicide Branch

Registration Division (7505P)

D380767

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

CHEMICAL SAFETY

AND POLLUTION PREVENTION

Chronic Aggregate

Exposure and Risk Assessment for the 

s and Establish Tolerances

Section 3
Mefenpyr-diethyl Dietary Exposure and Risk Assessment D380767

PC Code: 811800

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Executive Summary

A chronic aggregate dietary (food and drinking water) exposure and risk assessment was 

conducted using the Dietary Exposure Evaluation Model software with the Food 

Commodity Intake Database DEEM-FCIDTM, Version 2.03 which uses food consumption 

data from the U.S. Department of Agriculture’s Continuing Surveys of Food Intakes by

Individuals (CSFII) from 1994-1996 and 1998. The analysis was performed to support a 

Section 3 request to add new uses of the safener mefenpyr-diethyl, also known as HOE107892, and to establish tolerances for sorghum and grasses grown for seed.

Acute Dietary Exposure Results and Characterization

No toxic effects attributable to a single exposure of mefenpyr-diethyl were seen in the 

database; therefore, an acute dietary endpoint was not selected and an acute dietary risk 

assessment was not conducted.

 

Chronic Dietary (Food and Drinking Water) Exposure Results and Characterization

A highly conservative chronic dietary risk assessment was conducted for food only and 

for food and drinking water for mefenpyr-diethyl using tolerance level residues and 

assuming 100% crop treated. Mefenpyr-diethyl dietary exposure from food alone based 

on the newly proposed use pattern results in an estimated risk equivalent to <1% of the 

chronic population adjusted dose (cPAD) for the general U.S. population and all 

regulated subpopulations. The highest estimated drinking water concentration (EDWC), 

the chronic groundwater EDWC of 4 μg/L (ppb), was used for this dietary assessment. 

Additionally, exposure from food and drinking water based on the newly proposed use 

pattern results in an estimated risk equivalent to <1% of the cPAD for the general 

population and all regulated subpopulations. 

Cancer Dietary Exposure Results and Characterization

Mefenpyr-diethyl is classified as a “not likely” human carcinogen; thus, a cancer dietary

risk assessment is not required.

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For 

acute and chronic assessments, the risk is expressed as a percentage of a maximum 

acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable 

adverse health effects). This dose is referred to as the population adjusted dose (PAD). 

The PAD is equivalent to the point of departure (POD, NOAEL, LOAEL, e.g.) divided 

by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary

risk exceeds 100% of the PAD. HED is generally concerned when estimated cancer risk 

exceeds one in one million. References which discuss the acute and chronic risk 

assessments in more detail are available on the EPA/pesticides web site: “Available 

Information on Assessing Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, 
Mefenpyr-diethyl Dietary Exposure and Risk Assessment D380767

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web link: http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf ; or see 

SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for mefenpyr-diethyl was conducted by Donna 

Davis (6/3/2008, D353114).

II. Residue Information

The residue of concern for both risk assessment and tolerance setting purposes in plants 

and animals is the parent compound, mefenpyr-diethyl, and its 2,4-dichlorophenylpyrazoline metabolites.

Tolerances for residues of the herbicide safener mefenpyr-diethyl are established under 

40 CFR §180.509. Tolerances in plant commodities range from 0.05 ppm in wheat and 

barley grain to 0.5 ppm in wheat and barley straw. The rotational crop tolerance for 

soybean and canola seed is 0.02 ppm. Animal commodity tolerances are established for 

cattle, goat, hog, horse, and sheep meat byproducts at 0.1 ppm.

Residue Data used for Acute, Chronic, and/or Cancer Assessments:

Tolerance level residues and the assumption that 100% of the crop is treated were 

incorporated into the chronic dietary risk assessment for all existing and proposed uses. 

The proposed tolerance for sorghum was also incorporated into the assessment at the 

tolerance level assuming 100% crop treated. The recommended tolerance level for 

sorghum grain is 0.04 ppm (A. LaMay, 2/22/11, D380768). 

HED notes that in a previous dietary exposure assessment (Y. Donovan, 11/22/2002, 

D286489) the following animal commodities were included: meat at 0.002 ppm, fat at 

0.01 ppm, and milk at 0.002 ppm. The tissue residues were applied to cattle, goats, hogs, 

horses and sheep. These residues were selected from an exaggerated rate goat 

metabolism study, and were recommended for use in risk assessment even though 

tolerances were not required. HED has reconsidered the metabolism data and concludes 

that given the exaggeration rate of the metabolism study, detectable residues of 

mefenpyr-diethyl and its regulated metabolites are unlikely to result in meat, fat, and 

milk; therefore, these residue values have been excluded in subsequent dietary exposure 

assessment.

Since barley and wheat field trials conducted at exaggerated rates (>5X) showed no 

detectable residues in wheat and barley grains, no tolerance is needed for processed 

commodities and concentration/reduction factors were not applied to wheat and barley

commodities in this assessment. No processing data were submitted depicting the fate of 

mefenpyr-diethyl residues of concern in processed soybean and canola commodities. 

However, given that residues above the limit of quantitation (LOQ) were found in only

one sample from the rotational crop field trials run at an exaggerate rate and the fact that 

the tolerance is set at the sum of the respective individual LOQs, HED waived the 

requirement for a processing study and concluded that it is unlikely that residues in 
Mefenpyr-diethyl Dietary Exposure and Risk Assessment D380767

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processed commodities will exceed the established tolerances for soybean seed and 

canola seed. Therefore, concentration/reduction factors were not applied to canola and 

soybean processed commodities in this assessment. 

No processing data have been submitted depicting fate of mefenpyr-diethyl residues of 

concern in processed sorghum commodities. Given that there were no residues above the 

LOQ in all grain samples from the sorghum crop field trials and the fact that the 

tolerances is set at the sum of respective individual LOQs, HED waives the requirement 

for a processing study and concludes that it’s unlikely that residues in processed 

commodities will exceed the established tolerances for sorghum. Therefore, 

concentration/reduction factors were not applied to sorghum processed commodities in 

this assessment. 

III. Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by the 

Environmental Fate and Effects Division (EFED) in response to tolerance petitions for 

uses on wheat and barley (A. Clem, 3/18/97, D226076; A. Clem, 11/26/01, D262735). 

The assessment was based on use of the safener at an exaggerated rate of 0.08 lb ai/A, 

which is higher than the currently requested use pattern; therefore, those estimated 

drinking water values remain valid and were incorporated directly into this dietary

assessment. Water residues were incorporated in the DEEM-FCID into the food 

categories “water, direct, all sources” and “water, indirect, all sources.” 

Monitoring data for mefenpyr-diethyl and its metabolites are not available; therefore,

surface and ground water estimated drinking water concentrations (EDWCs) were 

derived from models. 

The chronic surface water EDWC was calculated from the EFED FIRST (Tier 1) index 

reservoir simulation model for a single application of HOE-107892 at an exaggerated rate 

of 0.090 kg/ha (0.080 lb/acre). The tabulated concentrations are the summations (in 

parent equivalent concentrations) of relatively short-lived parent and several longer-lived 

transformation products that are structurally similar to the parent compound. The chronic 

concentration of combined parent and metabolites computed from FIRST in parent 

equivalents is 3 ppb. 

The chronic groundwater EDWC was calculated using the SCI-GROW2 model. The 

database of pesticide chemicals used to develop and update the SCI-GROW2 regression 

model shows that the highest pesticide concentration measured on a one pound per acre 

application basis for a certain mobile and persistent pesticide of similar molecular weight 

is roughly 55 μg/L (ppb). The current minimum value for Koc in the database used to 

develop SCI-GROW2 is 11 mL/g, while maximum values for aerobic soil metabolism 

half-life are roughly 1000 days. Since HOE-107892 has Koc and aerobic soil metabolism 

half-lives well within the bounds covered by the model, as do its structurally similar 

transformation products (from collateral laboratory evidence and reasonable inference), 
Mefenpyr-diethyl Dietary Exposure and Risk Assessment D380767

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groundwater concentrations of HOE-107892 applied at exaggerated rate of 

0.080 lb/acre/year and any associated transformation products (in equivalent molar 

concentrations) are not likely to exceed individually, or in combination, a concentration 

of 4 μg/L (ppb).

The models and their descriptions are available at the EPA internet site: 

http://www.epa.gov/oppefed1/models/water/. 

The higher value of the two, the chronic groundwater EDWC of 4 μg/L (ppb), was used 

for this dietary assessment.

IV. DEEM-FCIDTM Program and Consumption Information

The mefenpyr-diethyl chronic dietary exposure assessment was conducted using the 

Dietary Exposure Evaluation Model software with the Food Commodity Intake Database 

DEEM-FCIDTM, Version 2.03 which incorporates consumption data from USDA’s 

Continuing Surveys of Food Intakes by Individuals (CSFII), 1994-1996 and 1998. The 

1994-96, 98 data are based on the reported consumption of more than 20,000 individuals 

over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) are linked 

to EPA-defined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; baked; 

or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation 

files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, 

consumption data are averaged for the entire U.S. population and within population 

subgroups. Based on analysis of the 1994-96, 98 CSFII consumption data, which took 

into account dietary patterns and survey respondents, HED concluded that it is most 

appropriate to report risk for the following population subgroups: the general U.S. 

population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-

19, adults 20-49, females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or 

food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied 

by the average daily consumption estimate for that food/food form to produce a residue 

intake estimate. The resulting residue intake estimate for each food/food form is summed 

with the residue intake estimates for all other food/food forms on the commodity residue 

list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg 

body weight/day and as a percent of the cPAD. This procedure is performed for each 

population subgroup.

V. Toxicological Information

HED reviewed the toxicological database for mefenpyr-diethyl in conjunction with the 

request to establish new rotational crop tolerances as a result of increasing the use rate for 

this safener. The following conclusions with respect to toxicological endpoints for 

dietary risk assessment were reached. No toxic effects attributable to a single exposure 
Mefenpyr-diethyl Dietary Exposure and Risk Assessment D380767

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of mefenpyr-diethyl were seen in the database; therefore, an acute dietary endpoint was 

not selected. For dietary analysis, only a chronic endpoint was selected (Table 1). 

Mefenpyr-diethyl is classified as a “not likely” human carcinogen; thus, a cancer dietary 

risk assessment is not required. 

Based on a review of the toxicological database for mefenpyr-diethyl and the available 

exposure information, HED has determined that the FQPA Safety Factor can be reduced 

to 1X.

Table 1. Summary of Toxicological Doses and Endpoints for Mefenpyr-Diethyl for Use in 

Dietary Exposure Risk Assessments

Exposure/

Scenario

Point of 

Departure

Uncertainty/FQPA 

Safety Factors

RfD, PAD, Level 

of Concern 

Study and Toxicological 

Effects

Acute 

Dietary 

No appropriate endpoint was identified in oral toxicity studies including the developmental 

studies in rats and rabbits for risk assessment for any subpopulation.

Chronic 

Dietary (All 

Populations)

NOAEL = 

51

mg/kg/day

UFA= 10x

UFH= 10x

FQPA SF= 1x

Chronic RfD = 

0.51 mg/kg/day

cPAD = 

0.51 mg/kg/day

Chronic Toxicity Study in the 

Beagle Dog. 

LOAEL = 260 mg/kg/day based 

on adverse findings in the liver 

(cholestasis, increased alkaline 

phosphatase, and increased liver 

weight in both sexes).

Co-critical study: Chronic 

Toxicity Study in the Rat.

LOAEL = 252♀/318♂ 

mg/kg/day based on significant 

increase in reticulocyte counts. 

(NOAEL = 60 mg/kg/day)

Cancer (oral, dermal, 

inhalation) Mefenpyr-diethyl is classified as not likely to be a human carcinogen

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and 

used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human 

exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = 

uncertainty factor. UFA = extrapolation from animal to human (intraspecies). UFH = potential variation in sensitivity 

among members of the human population (interspecies). FQPA SF = FQPA Safety Factor. PAD = population adjusted 

dose (a = acute, c = chronic). RfD = reference dose.

VI. Results/Discussion 

As stated above, for chronic assessments, HED is concerned when dietary risk exceeds 

100% of the PAD. The DEEM-FCIDTM analyses estimate the dietary exposure of the 

U.S. population and various population subgroups. The results reported in Table 2, 

below, are for the general U.S. Population, all infants (<1 year old), children 1-2, children 

3-5, children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50+ years. 

Results of Chronic Dietary (Food and Drinking Water) Exposure Analysis

Mefenpyr-diethyl chronic dietary exposure from food alone based on the newly proposed 

use pattern results in an estimated risk equivalent to <1% of the cPAD for the general 
Mefenpyr-diethyl Dietary Exposure and Risk Assessment D380767

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U.S. population and all regulated subpopulations. Additionally, exposure from food and 

drinking water based on the newly proposed use pattern results in an estimated risk 

equivalent to <1% of the cPAD for the general populations and all regulated 

subpopulations. The results of the chronic dietary exposure analysis for all 

subpopulations are reported in Table 2, below. 

Table 2. Summary of Dietary (Food Only and Food and Drinking Water) Exposure 

and Risk for Mefenpyr-diethyl

Population Subgroup

Chronic Dietary

Food Only

Chronic Dietary

Food and Water

Dietary 

Exposure

(mg/kg/day)

% cPAD*

Dietary 

Exposure

(mg/kg/day)

% cPAD*

General U.S. Population 0.000105 <1 0.000189 <1

All Infants (< 1 year old) 0.000067 <1 0.000343 <1

Children 1-2 years old 0.000235 <1 0.000360 <1

Children 3-5 years old 0.000239 <1 0.000356 <1

Children 6-12 years old 0.000167 <1 0.000248 <1

Youth 13-19 years old 0.000101 <1 0.000162 <1

Adults 20-49 years old 0.000089 <1 0.000167 <1

Adults 50+ years old 0.000070 <1 0.000153 <1

Females 13-49 years old 0.000080 <1 0.000158 <1

* The values for the highest exposed population for each type of risk assessment are bolded

VII. Characterization of Inputs/Outputs

HED has conducted a highly conservative, screening level chronic dietary exposure and 

risk assessment for mefenpyr-diethyl. The assessment assumes that all commodities for 

which there are tolerances contain residues of mefenpyr-diethyl at the tolerance level. 

Additionally, no reduction factors were used for processed commodities and modeled 

values were used for drinking water. Based on the conservative inputs into the analysis, 

it is unlikely that the assessment will underestimate chronic dietary risks from the newly

proposed use pattern for this safener. 

Additional refinements including the use of percent crop treated information and 

monitoring data could be incorporated into the assessment. However, since risk estimates 

are not of concern, a more highly refined assessment is not needed at this time.

VIII. Conclusions
Mefenpyr-diethyl Dietary Exposure and Risk Assessment D380767

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A highly conservative chronic dietary (food and water) risk assessment was conducted 

for the proposed tolerance in/on sorghum of mefenpyr-diethyl as a safener. HED has no 

concern for the chronic dietary risk resulting from the new use on sorghum since the 

chronic dietary exposure to mefenpyr from food and drinking water results in an 

estimated risk that is <1% of the cPAD for the U.S. population and all regulated 

subgroups based on the new use pattern.

IX. List of Attachments

• Chronic Food Only Residue Input File

• Chronic Food Only Results File

• Chronic Food and Water Residue Input File

• Chronic Food and Water Results File
Mefenpyr-diethyl Dietary Exposure and Risk Assessment D380767

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Attachment 1. Chronic Food Only Residue Input File

U.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for MEFENPYR-DIETHYL 1994-98 data

Residue file: C:\Documents and Settings\ALEMAY\My Documents\Mefenpyr-diethyl\Dietary 

Exposure\DEEM Runs\Mefenpyr_Chronic_Sorghum_Foodonly.R98

 Adjust. #2 NOT used

Analysis Date 09-16-2010 Residue file dated: 09-16-2010/09:12:40/8

Reference dose (RfD) = 0.51 mg/kg bw/day

--------------------------------------------------------------------------------

Food Crop Residue Adj.Factors Comment

EPA Code Grp Food Name (ppm) 

 #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ -------

15000250 15 Barley, pearled barley 0.050000 1.000 1.000 

15000251 15 Barley, pearled barley-babyfood 0.050000 1.000 1.000 

15000260 15 Barley, flour 0.050000 1.000 1.000 

15000261 15 Barley, flour-babyfood 0.050000 1.000 1.000 

15000270 15 Barley, bran 0.050000 1.000 1.000 

21000460 M Beef, meat byproducts 0.100000 1.000 1.000 

21000461 M Beef, meat byproducts-babyfood 0.100000 1.000 1.000 

21000480 M Beef, kidney 0.100000 1.000 1.000 

21000490 M Beef, liver 0.100000 1.000 1.000 

21000491 M Beef, liver-babyfood 0.100000 1.000 1.000 

23001700 M Goat, meat byproducts 0.100000 1.000 1.000 

23001720 M Goat, kidney 0.100000 1.000 1.000 

23001730 M Goat, liver 0.100000 1.000 1.000 

25002920 M Pork, meat byproducts 0.100000 1.000 1.000 

25002921 M Pork, meat byproducts-babyfood 0.100000 1.000 1.000 

25002940 M Pork, kidney 0.100000 1.000 1.000 

25002950 M Pork, liver 0.100000 1.000 1.000 

20003190 20 Rapeseed, oil 0.020000 1.000 1.000 

20003191 20 Rapeseed, oil-babyfood 0.020000 1.000 1.000 

26003400 M Sheep, meat byproducts 0.100000 1.000 1.000 

26003420 M Sheep, kidney 0.100000 1.000 1.000 

26003430 M Sheep, liver 0.100000 1.000 1.000 

15003440 15 Sorghum, grain 0.040000 1.000 1.000 New to

 Full comment: New tolerance

15003450 15 Sorghum, syrup 0.040000 1.000 1.000 New to

 Full comment: New tolerance

06003470 6 Soybean, seed 0.020000 1.000 1.000 

06003480 6 Soybean, flour 0.020000 1.000 1.000 

06003481 6 Soybean, flour-babyfood 0.020000 1.000 1.000 

06003490 6 Soybean, soy milk 0.020000 1.000 1.000 

06003491 6 Soybean, soy milk-babyfood or in 0.020000 1.000 1.000 

06003500 6 Soybean, oil 0.020000 1.000 1.000 

06003501 6 Soybean, oil-babyfood 0.020000 1.000 1.000 

15004010 15 Wheat, grain 0.050000 1.000 1.000 

15004011 15 Wheat, grain-babyfood 0.050000 1.000 1.000 

15004020 15 Wheat, flour 0.050000 1.000 1.000 

15004021 15 Wheat, flour-babyfood 0.050000 1.000 1.000 

15004030 15 Wheat, germ 0.050000 1.000 1.000 

15004040 15 Wheat, bran 0.050000 1.000 1.000 
Mefenpyr-diethyl Dietary Exposure and Risk Assessment D380767

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Attachment 2. Chronic Food Only Results File

U.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for MEFENPYR-DIETHYL (1994-98 data)

Residue file name: C:\Documents and Settings\ALEMAY\My Documents\Mefenpyr-diethyl\Dietary 

Exposure\DEEM Runs\Mefenpyr_Chronic_Sorghum_Foodonly.R98

 Adjustment factor #2 NOT used.

Analysis Date 09-16-2010/09:13:46 Residue file dated: 09-16-2010/09:12:40/8

Reference dose (RfD, Chronic) = .51 mg/kg bw/day

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ---------------

U.S. Population (total) 0.000105 0.0%

U.S. Population (spring season) 0.000107 0.0%

U.S. Population (summer season) 0.000102 0.0%

U.S. Population (autumn season) 0.000104 0.0%

U.S. Population (winter season) 0.000106 0.0%

Northeast region 0.000109 0.0%

Midwest region 0.000111 0.0%

Southern region 0.000099 0.0%

Western region 0.000104 0.0%

Hispanics 0.000097 0.0%

Non-hispanic whites 0.000106 0.0%

Non-hispanic blacks 0.000103 0.0%

Non-hisp/non-white/non-black 0.000103 0.0%

All infants (< 1 year) 0.000067 0.0%

Nursing infants 0.000030 0.0%

Non-nursing infants 0.000081 0.0%

Children 1-6 yrs 0.000234 0.0%

Children 7-12 yrs 0.000159 0.0%

Females 13-19 (not preg or nursing) 0.000089 0.0%

Females 20+ (not preg or nursing) 0.000072 0.0%

Females 13-50 yrs 0.000083 0.0%

Females 13+ (preg/not nursing) 0.000085 0.0%

Females 13+ (nursing) 0.000093 0.0%

Males 13-19 yrs 0.000113 0.0%

Males 20+ yrs 0.000092 0.0%

Seniors 55+ 0.000069 0.0%

Children 1-2 yrs 0.000235 0.0%

Children 3-5 yrs 0.000239 0.0%

Children 6-12 yrs 0.000167 0.0%

Youth 13-19 yrs 0.000101 0.0%

Adults 20-49 yrs 0.000089 0.0%

Adults 50+ yrs 0.000070 0.0%

Females 13-49 yrs 0.000080 0.0%

-------------------------------------------------------------------------------
Mefenpyr-diethyl Dietary Exposure and Risk Assessment D380767

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Attachment 3. Chronic Food and Water Residue Input File

U.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for MEFENPYR-DIETHYL 1994-98 data

Residue file: C:\Documents and Settings\ALEMAY\My Documents\Mefenpyr-diethyl\DEEM 

Runs\Mefenpyr_Chronic_Sorghum_FoodandWater.R98

 Adjust. #2 NOT used

Analysis Date 09-15-2010 Residue file dated: 09-15-2010/15:01:35/8

Reference dose (RfD) = 0.51 mg/kg bw/day

--------------------------------------------------------------------------------

Food Crop Residue Adj.Factors Comment

EPA Code Grp Food Name (ppm) 

 #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ -------

15000250 15 Barley, pearled barley 0.050000 1.000 1.000 

15000251 15 Barley, pearled barley-babyfood 0.050000 1.000 1.000 

15000260 15 Barley, flour 0.050000 1.000 1.000 

15000261 15 Barley, flour-babyfood 0.050000 1.000 1.000 

15000270 15 Barley, bran 0.050000 1.000 1.000 

21000460 M Beef, meat byproducts 0.100000 1.000 1.000 

21000461 M Beef, meat byproducts-babyfood 0.100000 1.000 1.000 

21000480 M Beef, kidney 0.100000 1.000 1.000 

21000490 M Beef, liver 0.100000 1.000 1.000 

21000491 M Beef, liver-babyfood 0.100000 1.000 1.000 

23001700 M Goat, meat byproducts 0.100000 1.000 1.000 

23001720 M Goat, kidney 0.100000 1.000 1.000 

23001730 M Goat, liver 0.100000 1.000 1.000 

25002920 M Pork, meat byproducts 0.100000 1.000 1.000 

25002921 M Pork, meat byproducts-babyfood 0.100000 1.000 1.000 

25002940 M Pork, kidney 0.100000 1.000 1.000 

25002950 M Pork, liver 0.100000 1.000 1.000 

20003190 20 Rapeseed, oil 0.020000 1.000 1.000 

20003191 20 Rapeseed, oil-babyfood 0.020000 1.000 1.000 

26003400 M Sheep, meat byproducts 0.100000 1.000 1.000 

26003420 M Sheep, kidney 0.100000 1.000 1.000 

26003430 M Sheep, liver 0.100000 1.000 1.000 

15003440 15 Sorghum, grain 0.040000 1.000 1.000 New to

 Full comment: New tolerance

15003450 15 Sorghum, syrup 0.040000 1.000 1.000 New to

 Full comment: New tolerance

06003470 6 Soybean, seed 0.020000 1.000 1.000 

06003480 6 Soybean, flour 0.020000 1.000 1.000 

06003481 6 Soybean, flour-babyfood 0.020000 1.000 1.000 

06003490 6 Soybean, soy milk 0.020000 1.000 1.000 

06003491 6 Soybean, soy milk-babyfood or in 0.020000 1.000 1.000 

06003500 6 Soybean, oil 0.020000 1.000 1.000 

06003501 6 Soybean, oil-babyfood 0.020000 1.000 1.000 

86010000 O Water, direct, all sources 0.004000 1.000 1.000 

86020000 O Water, indirect, all sources 0.004000 1.000 1.000 

15004010 15 Wheat, grain 0.050000 1.000 1.000 

15004011 15 Wheat, grain-babyfood 0.050000 1.000 1.000 

15004020 15 Wheat, flour 0.050000 1.000 1.000 

15004021 15 Wheat, flour-babyfood 0.050000 1.000 1.000 

15004030 15 Wheat, germ 0.050000 1.000 1.000 

15004040 15 Wheat, bran 0.050000 1.000 1.000 
Mefenpyr-diethyl Dietary Exposure and Risk Assessment D380767

PC Code: 811800

Page 12 of 12

Attachment 4. Chronic Food and Water Results File

U.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for MEFENPYR-DIETHYL (1994-98 data)

Residue file name: C:\Documents and Settings\ALEMAY\My Documents\Mefenpyr-diethyl\DEEM 

Runs\Mefenpyr_Chronic_Sorghum_FoodandWater.R98

 Adjustment factor #2 NOT used.

Analysis Date 09-15-2010/15:03:00 Residue file dated: 09-15-2010/15:01:35/8

Reference dose (RfD, Chronic) = .51 mg/kg bw/day

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 Total exposure by population subgroup

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 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ---------------

U.S. Population (total) 0.000189 0.0%

U.S. Population (spring season) 0.000190 0.0%

U.S. Population (summer season) 0.000193 0.0%

U.S. Population (autumn season) 0.000186 0.0%

U.S. Population (winter season) 0.000187 0.0%

Northeast region 0.000186 0.0%

Midwest region 0.000196 0.0%

Southern region 0.000179 0.0%

Western region 0.000200 0.0%

Hispanics 0.000193 0.0%

Non-hispanic whites 0.000189 0.0%

Non-hispanic blacks 0.000183 0.0%

Non-hisp/non-white/non-black 0.000206 0.0%

All infants (< 1 year) 0.000343 0.1%

Nursing infants 0.000133 0.0%

Non-nursing infants 0.000423 0.1%

Children 1-6 yrs 0.000351 0.1%

Children 7-12 yrs 0.000236 0.0%

Females 13-19 (not preg or nursing) 0.000148 0.0%

Females 20+ (not preg or nursing) 0.000157 0.0%

Females 13-50 yrs 0.000165 0.0%

Females 13+ (preg/not nursing) 0.000166 0.0%

Females 13+ (nursing) 0.000210 0.0%

Males 13-19 yrs 0.000175 0.0%

Males 20+ yrs 0.000168 0.0%

Seniors 55+ 0.000152 0.0%

Children 1-2 yrs 0.000360 0.1%

Children 3-5 yrs 0.000356 0.1%

Children 6-12 yrs 0.000248 0.0%

Youth 13-19 yrs 0.000162 0.0%

Adults 20-49 yrs 0.000167 0.0%

Adults 50+ yrs 0.000153 0.0%

Females 13-49 yrs 0.000158 0.0%

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