Initial to indicate certification as to information on this page (full text of certification is on page one). Date INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary. 2. Case # and Name 3. Date and Type of DCI and Number

4. EPA Product Registration 5. I wish to cancel this product registration voluntarily 6. Generic Data 7. Product Specific Data 6a. I am claiming a Generic Data Exemption because I obtain the active ingredient from the source EPA registration number listed below. 6b. I agree to satisfy Generic Data Requirements as indicated on the attached form entitled "Requirements Status and Registrant's Response." 7a. My product is an MUP and I agree to satisfy the MUP requirement on the attached form entitled "Requirements Status and Registrant's Response." 7b. My product is an EUP and I agree to satisfy the EUP requirement on the attached form entitled "Requirements Status and Registrant's Response." OMB Approval 2070-0174

1. Company Name and Address N/A - Isoxaben Chemical # and Name: 125851 Isoxaben 18-Feb-2010 GENERIC ID # GDCI-125851-965 

### United States Environmental Protection Agency

Washington, D.C. 20460 DATA CALL-IN RESPONSE 1 Page of 1

8. Certification: I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any knowingly false or misleading statement may be punishable by fine, imprisonment or both under applicable law. Signature and Title of Company's Authorized Representative ______________________________________________________ 10. Name of Company N/A N/A

9. Date

11. Phone NumberInitial to indicate certification as to information on this page (full text of certification is on page one) 13. Phone Number 10. Certification: I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any knowingly false or misleading statement may be punishable by fine, imprisonment or both under applicable law.
12. Name of Company 11. Date OMB Approval 2070-0174 

### United States Environmental Protection Agency

Washington, D.C. 20460 REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline Requirement Number 5. Study Title Progress Reports



### 2 3 1 6. Use

Pattern 7. Test Substance 8. Time Frame (Months) 9. Registrant

Response P R O T O C O L 1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

Signature and Title of Company's Authorized Representative _________________________________________________________________

Environmental Fate Data Requirements (Conventional Chemical)
Nontarget Plant Protection Data Requirements (Conventional Chemical)

Product Chemistry Data Requirements (Conventional Chemical) 835.2410

850.4225 850.4250 850.4400

830.7050 Photodegradation of parent and degradates in soil

Seedling emergence, Tier II Vegetative vigor, Tier II Aquatic plant toxicity test using Lemna spp. Tiers I and II
UV/Visible absorption N/A - Isoxaben Chemical # and Name: 125851 Isoxaben 18-Feb-2010 GENERIC ID # GDCI-125851-965

J,C,Q,II

J,C,Q,II J,C,Q,II J,C,Q,II

J,C,Q,II EP; PAI; TGAI

TEP TEP EP; PAI; TGAI

EP; PAI; TGAI 12

12 12 12

8 1 of Page

(3) (4) N

N N N

N 2Date OMB Approval 2070-0174 

### United States Environmental Protection Agency

Washington, D.C. 20460 REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline Requirement Number 5. Study Title Progress Reports



### 2 3 1 6. Use

Pattern 7. Test Substance 8. Time Frame (Months) 9. Registrant

Response P R O T O C O L 1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

Toxicology Data Requirements (Conventional Chemical) 870.3465 870.6200 870.7800 90-day inhalation toxicity

Neurotoxicity screening battery Immunotoxicity N/A - Isoxaben Chemical # and Name: 125851 Isoxaben 18-Feb-2010 GENERIC ID # GDCI-125851-965

J,C,Q,II J,C,Q,II J,C,Q,II TGAI TGAI TGAI 24 24 0 2 of Page

(2, 5) (1, 6, 7) N

N Y 2

### United States Environmental Protection Agency Washington, D.C. 20460 FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS N/A - Isoxaben GDCI-125851-965

1 2 3 4 5 6 7 Key: Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

The timeframe for completing the acute neurotoxicity screening study is 12 months. Required if there is the likelihood of significant repeated inhalation exposure to the pesticide as a gas, vapor, or aerosol. Required if a terrestrial species exhibits a 25 percent or greater detrimental effect in Tier 1. Test species should be the one that exhibited detrimental effects in Tier 1 testing. Required if a terrestrial species exhibits a 25 percent or greater detrimental effect in Tier 1. Test species should be the species that showed detrimental effects in the Tier I testing. Based on estimates of the magnitude and duration of human exposure, studies of shorter duration, e.g., 21 or 28-days, may be sufficient to satisfy this requirement. Registrants should consult with the Agency to determine whether studies of shorter duration would meet this requirement. All 90-day subchronic studies in rats can be designed to simultaneously fulfill the requirements of the 90-day neurotoxicity study using separate groups of animals for testing. Although the subchronic guidelines include the measurement of neurological endpoints, they do not meet the requirement of the 90-day neurotoxicity study (guideline 870.6200). Additional measurements such as cholinesterase activity for certain pesticides, e.g., organophosphates and some carbamates, will also be required. The route of exposure must correspond with the primary route of exposure. Case # and Name: DCI Number: 1 Page: of 1

Footnotes: The following footnotes are referenced in column two (5. Study Title) of the Requirements Status and Registrant's Response form. These footnotes apply in addition to any test notes included in 40 CFR Part 158 with respect to the particular data requirement. Use Categories Key: C - Terrestrial nonfood crop J - Forestry use Q - Residential outdoor use II - Residential Use Conventional Chemical

### United States Environmental Protection Agency Washington, D.C. 20460 LIST OF ALL REGISTRANTS SENT THIS DATA CALL-IN NOTICE N/A - Isoxaben Case # and Name: 1 Page: of 1

83558 62719 CELSIUS PROPERTY B.V., AMSTERDAM

(NL) DOW AGROSCIENCES LLC Co. Nr. Company Name Agent For Company MAKHTESHIM AGAN OF NORTH AMERICA, INC. 3120 HIGHWOODS BLVD., SUITE 100 9330 ZIONSVILLE RD 308/2E Address City ZIP RALEIGH INDIANAPOLIS 27604 462681054 OMB Approval 2070-0174

State NC IN DCI Number: GDCI-125851-965

# LINKS TO FORMS: The pesticide registration forms that are listed below can be found at: http://www.epa.gov/opprd001/forms/ Link to C onfidential Statement of Formula and Instructions (Form # 8570 -4 

# ) http://www.epa.gov/opprd001/forms/8570 - 4.pdf C ertification of Attempt to Enter Into an Agreement With Registrants for Development of Data (Form # 8570 - 32 

# ) http://www.epa.gov/opprd001/forms/8570 - 32.pdf
C ertification With Respect to Citation of Data (Form # 8570 - 34 

# ) http://www.epa.gov/opprd001/forms/8570 - 34.pdf