<PAGE>

                                                                  EXHIBIT 10.72

* Certain confidential information contained in this document, marked by
brackets, has been omitted and filed with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

================================================================================

                                LEASE AGREEMENT

                                 BY AND BETWEEN

                             HMS GATEWAY OFFICE L.P.,
                         a Delaware limited partnership

                                   As LANDLORD

                                       and

                          COULTER PHARMACEUTICAL, INC.,
                             a Delaware corporation

                                    AS TENANT

                               DATED May 19, 2000

================================================================================



<PAGE>

                               TABLE OF CONTENTS


<TABLE>
<CAPTION>
                                                                                    PAGE
<S>                                                                                 <C>
 Basic Lease Information .............................................................iv

  1. Demise ..........................................................................1

  2. Premises ........................................................................1

  3. Term.............................................................................2

  4. Rent.............................................................................2

  5. Utility Expenses ................................................................10

  6. Late Charge .....................................................................11

  7. Security Deposit ................................................................11

  8. Possession ......................................................................12

  9. Use of Premises .................................................................13

  10.Acceptance of Premises ..........................................................15

  11.Surrender........................................................................15

  12.Alterations and Additions .......................................................16

  13.Maintenance and Repairs of Premises .............................................19

  14.Landlord's Insurance ............................................................20

  15.Tenant's Insurance ..............................................................20

  16.Indemnification .................................................................21

  17.Subrogation......................................................................22

  18.Signs............................................................................22

  19.Free from Liens .................................................................23

  20.Entry by Landlord ...............................................................23

  21.Destruction and Damage ..........................................................23

  22.Condemnation ....................................................................25
</TABLE>


                                       i

<PAGE>


<TABLE>
<S>                                                                                  <C>
  23. Assignment and Subletting ......................................................26

  24. Tenant's Default ...............................................................29

  25. Landlord's Remedies ............................................................31

  26. Landlord's Right to Perform Tenant's Obligations ...............................33

  27. Attorneys' Fees ................................................................34

  28. Taxes ..........................................................................34

  29. Effect of Conveyance ...........................................................34

  30. Tenant's Estoppel Certificate ..................................................35

  31. Subordination ..................................................................35

  32. Environmental Covenants ........................................................36

  33. Notices ........................................................................39

  34. Waiver..........................................................................39

  35. Holding Over....................................................................39

  36. Successors and Assigns .........................................................40

  37. Time ...........................................................................40

  38. Brokers.........................................................................41

  39. Limitation of Liability ........................................................41

  40: Financial Statements ...........................................................41

  41. Rules and Regulations ..........................................................41

  42. Mortgagee Protection ...........................................................42

  43. Entire Agreement ...............................................................42

  44. Interest........................................................................42

  45. Interpretation..................................................................42

  46. Representations and Warranties..................................................43

  47. Security........................................................................44
</TABLE>


                                       ii

<PAGE>

<TABLE>
<S>                                                                                  <C>
 48. Jury Trial Waiver ...............................................................44

 49. Option to Renew .................................................................44

 50. Right of First Offer ............................................................46

 51. Independent Obligations..........................................................47

 52. Memorandum of Lease .............................................................47
</TABLE>

                  Exhibit

                     A       Base Building Construction Agreement

                     B       Premises Construction Agreement

                     C       Guaranty

                     D       Commencement Date Memorandum

                     E       Rules and Regulations

                     F       Hazardous Materials Disclosure Certificate

                     G       Initial Window Dates

                     H       Tenant's Property

                     I       Memorandum of Lease



                                      iii

<PAGE>

                                LEASE AGREEMENT

                            BASIC LEASE INFORMATION

                    Lease Date: May 19, 2000

                      Landlord: HMS Gateway Office, L.P.
                                a Delaware limited partnership

            Landlord's Address: c/o Hines Interests Limited Partnership
                                101 California Street, Suite 1000
                                San Francisco, California 94111-5848
                                Attention: Tom Kruggel

                                All notices sent to Landlord under this Lease
                                shall be sent to the above address, with copies
                                to:

                                      Hines Interests Limited Partnership
                                      651 Gateway Boulevard, Suite 1140
                                      South San Francisco, California 94080
                                      Attention: Catherine Fogelman

                        Tenant: Coulter Pharmaceutical, Inc.,
                                a Delaware corporation

       Tenant's Contact Person: William G. Harris

          Tenant's Address and  600 Gateway Boulevard
             Telephone Number:  South San Francisco, California 94080
                                (650)553-2000

       Premises Square Footage: 50,160 square feet, subject to final
                                determination by Landlord's Architect upon
                                commencement of the Term. Such measurement
                                to be made in accordance with Landlord's
                                Architect's standard measurement
                                procedures for research and development
                                space.

              Premises Address: 630 Gateway Boulevard
                                South San Francisco, California

                       Project: Approximately 7.85 acres of land commonly known
                                as Lot 2B of the Gateway Center and referred to
                                as the Gateway Technology Center, together with
                                the land and improvements on
                                which the Project is situated and all Common
                                Areas.

  Building (if not the same as  630 Gateway Boulevard
                  the Project): South San Francisco, California


                                       iv

<PAGE>

        Tenant's Proportionate  33.34%, subject to adjustment in accordance with
              Share of Project: Paragraph 4(c)(iii)

        Tenant's Proportionate
            Share of Building:  100%

                     Estimated
            Commencement Date:  November 30, 2001

              Expiration Date:  November 13, 2010

            Monthly Base Rent:

<TABLE>
<CAPTION>
                                                           Monthly Base
                                       Period                  Rate              Monthly Base Rent
                               --------------------        -------------         -----------------
<S>                                                        <C>                   <C>
                               Commencement Date -
                               November 13, 2002               $1.74                $ 87,278.40

                               November 14, 2002 -
                               November 13, 2003               $1.81                $ 90,789.60

                               November 14, 2003 -
                               November 13, 2004               $1.89                $ 94,802.40

                               November 14, 2004 -
                               November 13, 2005               $1.96                $ 98,313.60

                               November 14, 2005 -
                               November 13, 2006               $2.04                $102,326.40

                               November 14, 2006 -
                               November 13, 2007               $2.12                $106,339.20

                               November 14, 2007 -
                               November 13, 2008               $2.21                $110,853.60

                               November 14, 2008 -
                               November 13, 2009               $2.29                $114,866.40

                               November 14, 2009 -
                               November 13, 2010               $2.39                $119,882.40
</TABLE>


                                The above Monthly Base Rent calculations are
                                subject to change after final determination of
                                the Premises Square Footage and any such
                                adjustment shall be based on the Monthly Base
                                Rate for each period set forth above.

                 Prepaid Rent:  None


                                       v

<PAGE>

   Prepaid Additional Rent: None

          Security Deposit: Seventy-Five Thousand Dollars ($75,000.00)

          Letter of Credit: Five Hundred Thousand Dollars ($500,000.00)

             Permitted Use: General office and research and development,
                            product development and light prototype
                            manufacturing associated with
                            biotechnology/pharmaceutical services. All uses must
                            be in accordance with zoning ordinances of the City
                            of South San Francisco.

Unreserved Parking Spaces:  One Hundred Fifty (150) non-exclusive and
                            undesignated parking spaces.

       Tenant's Allowance:  One Million Five Hundred Ninety-Six Thousand Five
                            Hundred Ninety-Two and 80/100 Dollars
                            ($1,596,592.80) (viz., $31.83 per square foot).
                            The foregoing figure is subject to change after
                            final determination of the Premises Square Footage.




                                       vi

<PAGE>

                                 LEASE AGREEMENT

        THIS LEASE AGREEMENT is made and entered into by and between Landlord
and Tenant on the Lease Date. The defined terms used in this Lease which are
defined in the Basic Lease Information attached to this Lease Agreement ("BASIC
LEASE INFORMATION") shall have the meaning and definition given them in the
Basic Lease Information. The Basic Lease Information, the exhibits, the addendum
or addenda described in the Basic Lease Information, and this Lease Agreement
are and shall be construed as a single instrument and are referred to herein as
the "LEASE".

1. DEMISE

        In consideration for the rents and all other charges and payments
payable by Tenant, and for the agreements, terms and conditions to be performed
by Tenant in this Lease, LANDLORD DOES HEREBY LEASE TO TENANT, AND TENANT DOES
HEREBY HIRE AND TAKE FROM LANDLORD, the Premises described below (the
"Premises"), upon the agreements, terms and conditions of this Lease for the
Term hereinafter stated.

2. PREMISES

        The "Premises" demised by this Lease consists of that certain building
(the "BUILDING") specified in the Basic Lease Information, which Building is to
be located in that certain real estate development (the "PROJECT") specified in
the Basic Lease Information. Tenant shall have the non-exclusive right (in
common with the other tenants, Landlord and any other person granted use by
Landlord) to use the Common Areas (as hereinafter defined), except that, with
respect to parking, Tenant shall have only a license to use the number of
non-exclusive and undesignated parking spaces set forth in the Basic Lease
Information in the Project's parking areas (the "PARKING AREAS"); provided,
however, that Landlord shall use commercially reasonable efforts to enforce
Tenant's right to use such parking spaces. No easement for light or air is
incorporated in the Premises. For purposes of this Lease, the term "COMMON
AREAS" shall mean all areas and facilities outside the Premises and within the
exterior boundary line of the Project that are from time to time provided and
designated by Landlord for the non-exclusive use of Landlord, Tenant and other
tenants of the Project and their respective employees, guests and invitees.

        Landlord shall cause the construction of the Base Building Improvements
in accordance with the terms and conditions of the Base Building Construction
Agreement attached hereto as Exhibit A. Additionally, Tenant shall cause the
construction of certain tenant improvements in the interior of the Premises in
accordance with the terms and conditions of the Premises Construction Agreement
attached hereto as EXHIBIT B.

        Except as otherwise provided in the last sentence of this Paragraph,
Landlord has the right, in its sole discretion, from time to time, to: (a) make
changes to the Common Areas, including, without limitation, changes in the
location, size, shape and number of driveways, entrances, parking spaces
(provided, however, that Landlord shall not have the right, except as otherwise
provided herein, to reduce the total number of parking spaces below the number
allocated to Tenant in the Basic Lease Information), parking areas, ingress,
egress, direction of driveways,


                                       1

<PAGE>

entrances, corridors and walkways; (b) close temporarily any of the Common Areas
for maintenance or construction purposes so long as reasonable access to the
Premises remains available; (c) add additional buildings and improvements to the
Common Areas or remove existing buildings or improvements therefrom; (d) use the
Common Areas while engaged in making additional improvements, repairs or
alterations to the Project or any portion thereof so long as reasonable access
to the Premises remains available; and (e) do and perform any other acts or make
any other changes in, to or with respect to the Common Areas and the Project as
Landlord may, in its sole discretion, deem to be appropriate. Notwithstanding
(a) and (c) above, Landlord shall make no material changes or add additional
buildings or material improvements to any portion of the Common Areas described
on the Site Plan, as defined in the Base Building Construction Agreement,
without obtaining Tenant's consent, which consent shall not be unreasonably
withheld, conditioned or delayed; provided, however, that such consent shall not
be required if any change or addition is required or requested by a governmental
agency having jurisdiction over the Project or as required by law.

3. TERM

        The term of this Lease (the "TERM") shall be for the period specified in
the Basic Lease Information, commencing on the Commencement Date (as defined on
and determined in accordance with Paragraph D of EXHIBIT B hereto). In the event
the actual Commencement Date, as determined pursuant to the foregoing, is a date
other than the Estimated Commencement Date specified in the Basic Lease
Information, then Landlord and Tenant shall promptly execute a Commencement Date
Memorandum in the form attached hereto as EXHIBIT D, wherein the parties shall
specify the Commencement Date.

        Notwithstanding anything herein to the contrary, this Lease shall expire
on the Expiration Date specified in the Basic Lease Information, irrespective of
whether the actual Commencement Date occurs on, prior to or after the Estimated
Commencement Date. In furtherance of the foregoing, Tenant acknowledges and
agrees that the Expiration Date shall be a fixed date and shall not be subject
to postponement or extension for any reason whatsoever.

4. RENT

        (a) BASE RENT AND LETTER OF CREDIT.

               (i) Base Rent. Tenant shall pay to Landlord, in advance on the
first day of each month, without further notice or demand and without offset or
deduction, the monthly installments of rent specified in the Basic Lease
Information (the "BASE RENT").

               (ii) Letter of Credit. Concurrently with execution hereof, Tenant
shall deliver to Landlord, at Tenant's sole cost and expense, the Letter of
Credit described below in the amount of Five Hundred Thousand Dollars
($500,000.00) as security for the full and faithful performance of Tenant's
covenants and obligations under this Lease. Upon the earlier of Tenant's
delivery to Landlord of a Guaranty by a Qualified Corporate Partner or
forty-five (45) days after the expiration of the Term or earlier termination,
the Letter of Credit shall be returned to Tenant, reduced by any amounts that
Landlord reasonably estimates to be required to remedy any defaults on the part
of Tenant hereunder. Landlord may (but shall not be required to) draw


                                       2

<PAGE>
upon the Letter of Credit and use the proceeds therefrom (the "LETTER OF CREDIT
PROCEEDS") or any portion thereof to cure any default under this Lease and to
compensate Landlord for any damage Landlord incurs as a result of such default,
it being understood that any use of the Letter of Credit Proceeds shall not
constitute a bar or defense to any of Landlord's remedies set forth in this
Lease. In such event and upon written notice from Landlord to Tenant specifying
the amount of the Letter of Credit Proceeds so utilized by Landlord, Tenant
shall immediately deliver to Landlord an amendment to the Letter of Credit or a
replacement Letter of Credit in an amount equal to one hundred percent (100
percent) of the applicable amount specified below. Tenant's failure to deliver
such replacement Letter of Credit to Landlord within ten (10) days of Landlord's
notice shall constitute a default hereunder.

               As used herein, Letter of Credit shall mean an unconditional,
stand-by irrevocable letter of credit (hereinafter referred to as the "LETTER OF
CREDIT") issued by a major national bank mutually satisfactory to Landlord and
Tenant (collectively, the "BANK"), naming Landlord as beneficiary, in the amount
of Five Hundred Thousand Dollars ($500,000.00). During the period from the
Commencement Date through the last day of the sixth Lease Year, the amount of
the Letter of Credit shall be reduced by Twenty Thousand Dollars ($20,000.00) on
the last day of each such Lease Year. During the period from the seventh Lease
Year through the Expiration Date, the amount of the Letter of Credit shall be
reduced by One Hundred Twenty-Six Thousand Six Hundred Sixty-Seven Dollars
($126,667.00) on the last day of each such Lease Year. The Letter of Credit
shall be for a one-year term and in any event shall be maintained in effect from
the date hereof through the date that is forty-five (45) days after expiration
of the Term or earlier termination. The Letter of Credit shall provide: (i) that
Landlord may make partial and multiple draws thereunder, up to the face amount
thereof, (ii) that Landlord may draw upon the Letter of Credit up to the full
amount thereof, as determined by Landlord, and the Bank will pay to Landlord the
amount of such draw upon receipt by the Bank of a sight draft signed by
Landlord, accompanied by a written statement from Landlord that Tenant is in
default under the Lease, and (iii) that, in the event of Landlord's assignment
or other transfer of its interest in this Lease, the Letter of Credit shall be
freely transferable (with Tenant paying all costs and expenses charged by the
Bank in connection with any such transfer) by Landlord, without recourse, to the
assignee or transferee of such interest and the Bank shall confirm the same to
Landlord and such assignee or transferee. In the event that the Bank shall fail
to notify Landlord at least forty-five (45) days prior to expiration of the
Letter of Credit that the Letter of Credit will be renewed for at least one (1)
year beyond the then applicable expiration date, and deliver to Landlord a
replacement Letter of Credit or a modification to the existing Letter of Credit
effectuating such renewal at least forty-five (45) days prior to expiration of
the Letter of Credit, and Tenant shall not have otherwise delivered to Landlord,
at least forty-five (45) days prior to the relevant annual expiration date, a
replacement Letter of Credit in the amount required hereunder and otherwise
meeting the requirements set forth above, then Landlord shall be entitled to
draw on the Letter of Credit as provided above, and shall hold the proceeds of
such draw as security for the full and faithful performance of Tenant's
obligations hereunder, until Tenant shall have provided a new Letter of Credit,
in which event Landlord shall promptly return the proceeds of such draw, not
otherwise used in accordance with the terms of the Lease, to Tenant.

               Notwithstanding the foregoing, at anytime after the commencement
of the Term, Landlord agrees to allow Tenant to replace the Letter of Credit as
required hereunder with an unconditional guaranty of Tenant's obligations under
this Lease in the form of EXHIBIT C (the


                                       3

<PAGE>

"GUARANTY"), from a Qualified Corporate Partner. A Qualified Corporate Partner
shall mean an Affiliate, as that term is defined in Paragraph 23 below, that, at
the time of executing the Guaranty, has: (i) a rating from Moody's of "Baa" or
better, or a rating from Standard & Poor's of "A-" or better, or (ii) cash and
cash equivalents in excess of Three Hundred Seventy-Five Million Dollars
($375,000,000.00), revenues in excess of Three Hundred Seventy-Five Million
Dollars ($375,000,000.00) and net profits in excess of Thirty Million Dollars
($30,000,000.00).

        As used in the preceding paragraph, the following terms shall have the
meanings set forth below:

               "CASH AND CASH EQUIVALENTS" shall mean the aggregate amount of
        the following, to the extent owned by the Guarantor free and clear of
        all loans, repayment obligations, encumbrances and rights of others: (i)
        cash on hand; (ii) dollar demand deposits maintained in the United
        States with any commercial bank and dollar time deposits maintained in
        the United States with, or certificates of deposit having a maturity of
        one year or less issued by, any commercial bank or other financial
        institution acceptable to the Landlord; (iii) direct obligations of, or
        unconditionally guaranteed by, the United States and having a maturity
        of one year or less; and (iv) readily marketable commercial paper having
        a maturity of one year or less, issued by any corporation organized and
        existing under the laws of the United States or any state thereof or the
        District of Columbia and rated by Standard & Poor's or Moody's (or, if
        neither such organization shall rate such commercial paper at any time,
        rated by any nationally recognized rating organization in the United
        States) with the highest rating assigned by such organization.

               "REVENUES" shall mean increases in assets or decreases in
        liabilities from operation of Guarantor's business for the twelve (12)
        month period prior to the execution of the Guaranty, calculated in
        accordance with generally accepted accounting principles, consistently
        applied.

               "NET PROFITS" shall mean revenues, less the sum of expenses
        (including taxes, but excluding amortization and depreciation) and
        return of owners' equity, calculated in accordance with generally
        accepted accounting principles, consistently applied.

        As used in this Lease, the term "LEASE YEAR" shall mean a period of
twelve (12) full calendar months, except that (i) the first Lease Year shall
commence on the Commencement Date and shall end on November 13, 2002, and (ii)
each subsequent Lease Year shall be a period of twelve (12) calendar months
commencing on November 14 of the applicable year and ending on November 13 of
the following calendar year.

        (b) ADDITIONAL RENT. This Lease is intended to be a triple-net Lease
with respect to Landlord; and subject to Paragraph 13(b) below, the Base Rent
owing hereunder is (i) to be paid by Tenant net of all costs and expenses
relating to Landlord's ownership and operation of the Project and the Building,
and (ii) not to be reduced, offset or diminished, directly or indirectly, by any
cost, charge or expense payable hereunder by Tenant or by others in connection
with the Premises, the Building and/or the Project or any part thereof. The
provisions of this Paragraph 4(b) for the payment of Tenant's Proportionate
Share(s) of Expenses (as hereinafter


                                       4

<PAGE>

defined) are intended to pass on to Tenant its share of all such costs and
expenses. In addition to the Base Rent, Tenant shall pay to Landlord, in
accordance with this Paragraph 4, Tenant's Proportionate Share(s) of all costs
and expenses paid or incurred in connection with the operation, maintenance,
management and repair of the Premises, the Building and/or the Project or any
part thereof (collectively, the "Expenses"), including, without limitation, all
the following items (Tenant's Proportionate Share(s) of the Expenses is
hereinafter referred to as "ADDITIONAL RENT"):

               (i) All supplies, materials and rental equipment used in the
operation and maintenance of the Project.

               (ii) Utilities, that are not separately metered to Tenant,
including, without limitation, water, power, gas, sewer, waste disposal,
communication and cable T.V. facilities, heating, cooling, lighting and
ventilation of the Project.

               (iii) A management fee equal to [*] of the annual Base Rent
derived from the Building; and all wages, salaries and other compensation for
any employees who provide service to the Building and/or the Project, provided
that such wages, salaries and other compensation shall not exceed [*] in any
given year (the "WAGE CEILING") (such Wage Ceiling to increase each year by [*]
of the Wage Ceiling for the preceding year).

               (iv) Legal and accounting services for the Project, including,
but not limited to, the costs of audits by certified public accountants of Basic
Operating Cost records; provided, however, that legal expense shall not include
the cost of (A) negotiating lease terms for prospective tenants, (B) negotiating
termination or extension of leases with existing tenants, (C) proceedings
against any other specific tenant relating to such tenant's breach of its lease,
including, without limitation, failure to pay rent or other sums due to Landlord
from such tenant, or (D) legal costs incurred in connection with development
and/or construction of the Project.

               (v) All insurance premiums and costs, including, but not limited
to, the premiums and costs of fire, casualty, liability, rental abatement and
earthquake insurance applicable to the Project and Landlord's personal property
used in connection therewith (and all amounts paid as a result of loss sustained
that would be covered by such policies but for "deductible" or self-insurance
provisions); provided, however, that Landlord may, but shall not be obligated
to, carry earthquake insurance. Notwithstanding the foregoing, if Landlord
elects to carry earthquake insurance, Tenant shall only be obligated to pay the
following amounts on account of such earthquake insurance during any calendar
year: (A) if the premiums and costs associated with the earthquake insurance for
the Building carried by Landlord for any given year are equal to or less than
the Break Point defined below, Tenant shall pay 100% of such premiums and costs
as Additional Rent; or (B) if the premiums and costs associated with the
earthquake insurance for the Building carried by Landlord for any given year
exceed the Break Point, Tenant shall only pay 30% of such premiums and costs as
Additional Rent. For purposes of this provision, "BREAK POINT" shall equal
Fifteen Thousand Six Hundred Dollars ($15,600.00) (such amount to increase each
year by four percent (4%) of the Break Point for the preceding year). By way of
example, if the premium and costs for earthquake insurance carried by Landlord
in a calendar year are $14,500.00, Tenant shall be responsible for payment of
$14,500.00 as Additional Rent; however,

--------------
* Confidential treatment requested.

                                       5

<PAGE>

if the premiums and costs for earthquake insurance carried by Landlord in a
calendar year are $20,000.00, Tenant shall be responsible for paying $6,000.00
as Additional Rent. If for any reason the earthquake insurance carried by
Landlord is part of an umbrella or overall insurance policy covering the
Building, the Project and other buildings, the determination of premiums and
costs shall be based on the allocated portion of the premium and costs with
respect to the Building, as reasonably determined by Landlord.

               (vi) Repairs, replacements and general maintenance (except for
repairs and replacements (A) paid for from the proceeds of insurance, (B) paid
for directly by Tenant, other tenants or any third party, or (C) for the
benefit solely of tenants of the Project other than Tenant to the extent that
Tenant could not obtain similar services from Landlord without an obligation to
reimburse Landlord for the entire cost thereof under the provisions of this
Lease).

               (vii) All real estate or personal property taxes, possessory
interest taxes, business or license taxes or fees, service payments in lieu of
such taxes or fees, annual or periodic license or use fees ("REAL PROPERTY
TAXES"), including, but not limited to, all of the following: (A) all real
estate taxes and assessments, and all other taxes relating to, or levied,
assessed or imposed on, the Project, or any portion thereof, or interest
therein; (B) all taxes, assessments, charges, levies, fees, excises or
penalties, general and special, ordinary and extraordinary, unforeseen as well
as foreseen, of any kind and nature imposed, levied upon, measured by or
attributable to Landlord's equipment, furniture, fixtures and other property
located in, or used in connection with, the Project, or levied upon, measured by
or reasonably attributable to the cost or value of any of the foregoing; (C) all
other taxes, assessments, charges, levies, fees, or penalties, general and
special, ordinary and extraordinary, unforeseen as well as foreseen, of any kind
and nature imposed, levied, assessed, charged or collected by any governmental
authority or other entity either directly or indirectly (1) for public
improvements, user, maintenance or development fees, transit, housing,
employment, police, fire, open space, streets, sidewalks, utilities, job
training, child care or other governmental services or benefits, (2) upon or
with respect to the development, possession, leasing, operation, management,
maintenance, alteration, repair, use or occupancy of, or business operations in,
the Project, (3) upon, against or measured by the area of the Project, or uses
made thereof, or leases made to tenants thereof, or all or any part of the rents
collected or collectible from tenants thereof, and (4) for environmental matters
or as a result of the imposition of mitigation measures, including parking
taxes, employer parking regulations, or fees, charges or assessments as a result
of the treatment of the Project, or any portion thereof or interest therein, as
a source of pollution or storm water runoff; (D) any tax or excise, however
described, imposed in addition to, or in substitution partially or totally of,
any or all of the foregoing taxes, assessments, charges or fees; and (E) any and
all costs, expenses and attorneys' fees paid or incurred by Landlord in
connection with any proceeding or action to contest in whole or in part,
formally or informally, the imposition, collection or validity of any of the
foregoing taxes, assessments, charges or fees. If by law any Real Property Taxes
may be paid in installments at the option of the taxpayer, then Landlord shall
include within Real Property Taxes only those installments (including interest,
if any) which would become due by exercise of such option. Real estate taxes
shall not include (x) inheritance or estate taxes imposed upon or assessed
against the Project, or any part thereof or interest therein, or (y) taxes
computed upon the basis of the net income derived from the Project by Landlord
or the owner of any interest therein.


                                       6

<PAGE>

               (viii) Amortization (together with reasonable financing charges)
of capital improvements made to the Premises, the Building or the Project
subsequent to the Commencement Date that (A) are or will be required to comply
with applicable law, ordinance rule or regulation, enacted or enforced after the
Commencement Date, (B) are replacements of items which Landlord is obligated to
maintain, or (C) are designed to improve the operating efficiency of the Project
("LIMITED CAPITAL IMPROVEMENTS"); provided, however, that in the case of Limited
Capital Improvements made solely for effciency purposes, the amount chargeable
as an Expense in any year shall not exceed Landlord's reasonable determination
of the efficiency achieved either in direct cost savings, avoidance of cost
increases anticipated to be realized during the Term, or a combination of both.
As used in this Paragraph 4(b)(viii), "AMORTIZATION" shall mean allocation of
the cost equally to each year of useful life of the items being amortized or a
shorter period equal to the number of years required to recover the cost of said
item of capital improvement out of the savings in operating efficiency derived
therefrom.

               (ix) Capital improvements to the Premises, the Building or the
Project which do not constitute Limited Capital Improvements and which, in the
aggregate, do not exceed $5,000.00 for the year in question.

               Notwithstanding any other provision herein to the contrary, if
the Project is not fully occupied during any year of the Term, an adjustment
shall be made in computing Additional Rent for such year so that Additional Rent
shall be computed as though the Project had been fully occupied during such
year; provided, however, that in no event shall Landlord collect in total, from
Tenant and all other tenants of the Project, an amount greater than one hundred
percent (100%) of the actual Expenses during any year of the Term.

               Notwithstanding anything to the contrary contained in this Lease,
the following shall not be treated as Expenses for purposes of this Paragraph
4(b):

                      (A) Leasing commissions, attorneys' fees, costs,
disbursements, and other expenses incurred in connection with negotiations or
disputes with tenants (other than Tenant), or in connection with leasing,
renovating, or improving space for tenants or other occupants or prospective
tenants or other occupants of the Building.

                      (B) The cost of any service sold to any tenant (including
Tenant) or other occupant for which Landlord is entitled to be reimbursed as an
additional charge or rental over and above the basic rent and escalations
payable under the lease with that tenant.

                      (C) Any depreciation on the Building or Project.

                      (D) Expenses in connection with services or other benefits
of a type that are not provided to Tenant but which are provided to another
tenant or occupant of the Building or Project.

                      (E) Costs incurred due to Landlord's violation of any
terms or conditions of this Lease or any other lease relating to the Building or
Project.

                      (F) Overhead profit increments paid to Landlord's
subsidiaries or affiliates for management or other services on or to the
Building or for supplies or other materials to the


                                       7

<PAGE>

extent that the cost of the services, supplies, or materials exceeds the cost
that would have been paid had the services, supplies, or materials been provided
by unaffiliated parties on a competitive basis.

                      (G) All interest, loan fees, and other carrying costs
related to any mortgage or deed of trust or related to any capital item, and all
rental due under any ground or underlying lease, or any lease for any equipment
ordinarily considered to be of a capital nature (except janitorial equipment
which is not affixed to the Building.)

                      (H) Any compensation paid to clerks, attendants, or other
persons in commercial concessions operated by Landlord.

                      (I) Advertising and promotional expenditures.

                      (J) Costs of repairs and other work occasioned by fire,
windstorm, or other casualty that are insured or required to be insured by
Landlord hereunder, excluding any deductible.

                      (K) Any costs, fines, or penalties incurred due to
violations by Landlord of any governmental rule or authority, this Lease or any
other lease in the Project, or due to Landlord's gross negligence or willful
misconduct.

                      (L) Costs for sculpture, paintings, or other objects of
art (nor insurance thereon or extraordinary security in connection therewith).

                      (M) Wages, salaries, or other compensation paid to any
executive employees above the grade of building manager; provided, however, that
Landlord may charge as an Expense wages, salaries and other compensation for any
employees who provide service to the Building and/or Project in reasonable
proportion to the time spent in providing such service to the Building and/or
Project.

                      (N) The cost of correcting any building code or other
violations which were violations prior to the Commencement Date.

                      (O) The cost of containing, removing, or otherwise
remediating any contamination of the Project (including the underlying land and
ground water) by any Hazardous Materials either (1) where such contamination
existed prior to the date of this Lease or (2) where such costs, in any given
calendar year, exceed, in the aggregate, Twenty-five Thousand Dollars
($25,000.00). Nothing in this provision shall be deemed to limit Tenant's
liability with respect to Hazardous Materials as set forth in this Lease,
including, without limitation, Paragraph 16 and Paragraph 32 below.

                      (P) Any other expense, except as otherwise specifically
provided for in this Lease, that under generally accepted accounting principles
and practice consistently applied would not be considered a normal maintenance
or operating expense.


                                       8

<PAGE>

        (c) PAYMENT OF ADDITIONAL RENT

               (i) Upon commencement of this Lease, Landlord shall submit to
Tenant an estimate of monthly Additional Rent for the period between the
Commencement Date and the following December 31 and Tenant shall pay such
estimated Additional Rent on a monthly basis, in advance, on the first day of
each month. Tenant shall continue to make said monthly payments until notified
by Landlord of a change therein. By April 1 of each calendar year, Landlord
shall endeavor to provide to Tenant a statement (the "EXPENSE STATEMENT")
showing the actual Additional Rent due to Landlord for the prior calendar year,
to be prorated during the first year from the Commencement Date. If the total of
the monthly payments of Additional Rent that Tenant has made for the prior
calendar year is less than the actual Additional Rent chargeable to Tenant for
such prior calendar year, then Tenant shall pay the difference in a lump sum
within ten (10) days after receipt of such statement from Landlord. Any
overpayment by Tenant of Additional Rent for the prior calendar year shall be
credited towards the Additional Rent next due, or returned to Tenant in cash if
no subsequent Additional Rent will be payable.

               (ii) Landlord's then-current annual operating and capital budgets
for the Building and the Project or the pertinent part thereof shall be used for
purposes of calculating Tenant's monthly payment of estimated Additional Rent
for the current year, subject to adjustment as provided above. Landlord shall
make the final determination of Additional Rent for the year in which this Lease
terminates as soon as possible after termination of such year. Even though the
Term has expired and Tenant has vacated the Premises, Tenant shall remain liable
for payment of any amount due to Landlord in excess of the estimated Additional
Rent previously paid by Tenant, and, conversely, Landlord shall promptly return
to Tenant any overpayment. Failure of Landlord to submit statements as called
for herein shall not be deemed a waiver of Tenant's obligation to pay Additional
Rent as herein provided.

               (iii) With respect to Expenses which Landlord allocates to the
Building, Tenant's "PROPORTIONATE SHARE OF THE BUILDING" shall be the percentage
set forth in the Basic Lease Information as Tenant's Proportionate Share of the
Building, as adjusted by Landlord from time to time as a result of changes in
the square footage leased by Tenant hereunder. With respect to Expenses which
Landlord allocates to the Project as a whole or to only a portion of the
Project, Tenant's "PROPORTIONATE SHARE OF THE PROJECT" shall be, with respect to
Expenses which Landlord allocates to the Project as a whole, the percentage set
forth in the Basic Lease Information as Tenant's Proportionate Share of the
Project and, with respect to Expenses which Landlord allocates to only a portion
of the Project, a percentage calculated by Landlord from time to time in its
reasonable discretion and furnished to Tenant in writing (for example, if the
Building constitutes the only occupied premises of the Project, Landlord may
allocate 100% of such Expenses as lighting, landscaping and Common Area
maintenance to Tenant), in either case as adjusted by Landlord from time to time
for changes in the square footage leased by Tenant, addition of improvements to
the Project or changes in the physical size of the Project, whether such changes
in size are due to an addition to or a sale or conveyance of a portion of the
Project or otherwise. Notwithstanding the foregoing, Landlord may equitably
adjust Tenant's Proportionate Share of the Building or of the Project, as
applicable, for all or part of any item of expense or cost reimbursable by
Tenant that relates to a repair, replacement, or service that benefits only the
Premises.


                                       9

<PAGE>
        (d) GENERAL PAYMENT TERMS. The Base Rent, Additional Rent and all other
sums payable by Tenant to Landlord hereunder, including, without limitation, any
Late Charges, as defined below, assessed pursuant to Paragraph 6 below and any
interest assessed pursuant to Paragraph 44 below, are referred to as the "RENT".
All Rent shall be paid without deduction, offset or abatement in lawful money of
the United States of America. Checks are to be made payable to HMS Gateway
Office, L.P. and shall be mailed: c/o Hines Interests Limited Partnership, 101
California Street, Suite 1000, San Francisco, California 94111-5848, Attention:
Tom Kruggel or to such other person or place as Landlord may, from time to time,
designate to Tenant in writing. The Rent for any fractional part of a calendar
month at the commencement or termination of the Lease term shall be a prorated
amount of the Rent for a full calendar month based upon the number of days in
the month of the commencement or termination of the Lease term, as applicable.

        (e) AUDIT. Provided Tenant is not in Default under the terms of this
Lease, Tenant, at its sole cost and expense, shall have the right within ninety
(90) days after the delivery of each Expense Statement to review and audit
Landlord's books and records regarding such Expense Statement for the sole
purpose of determining the accuracy of such Expense Statement. Such review or
audit shall be performed by a nationally recognized accounting firm that
calculates its fees with respect to hours actually worked and that does not
discount its time or rate (as opposed to a calculation based upon percentage of
recoveries or other incentive arrangement), shall take place during normal
business hours in the office of Landlord or Landlord's property manager and
shall be completed within three (3) business days after the commencement
thereof, provided that Landlord or Landlord's property manager has made the
books and records regarding the Expense Statement available for review. If
Tenant does not so review or audit Landlord's books and records, Landlord's
Expense Statement shall be final and binding upon Tenant. In. the event that
Tenant determines on the basis of its review of Landlord's books and records
that the amount of Expenses paid by Tenant pursuant to this Paragraph 4 for the
period covered by such Expense Statement is less than or greater than the actual
amount properly payable by Tenant under the terms of this Lease, Tenant shall
promptly pay any deficiency to Landlord or Landlord shall promptly refund any
excess payment to Tenant and pay for any reasonable audit expenses, if such
excess payment exceeds the aggregate Expenses in Landlord's Expense Statement by
ten percent (10%), as the case may be.

5. UTILITY EXPENSES

        (a) Tenant shall pay the cost of all water, sewer use, sewer discharge
fees, gas, heat, electricity, refuse pick-up, janitorial service (including,
without limitation, exterior and interior window washing), telephone and all
materials and services or other utilities (collectively, "UTILITIES") billed or
metered separately to the Premises and/or Tenant, together with all taxes,
assessments, charges and penalties added to or included within such cost. Tenant
acknowledges that the Premises, the Building and/or the Project may become
subject to the rationing of Utility services or restrictions on Utility use as
required by a public utility company, governmental agency or other similar
entity having jurisdiction thereof. Tenant acknowledges and agrees that its
tenancy and occupancy hereunder shall be subject to such rationing or
restrictions as may be imposed upon Landlord, Tenant, the Premises, the Building
and/or the Project, and Tenant shall in no event be excused or relieved from any
covenant or obligation to be kept or performed by


                                       10

<PAGE>
Tenant by reason of any such rationing or restrictions. Tenant agrees to comply
with energy conservation programs implemented by Landlord by reason of
rationing, restrictions or Laws.

        (b) Landlord shall not be liable for any loss, injury or damage to
property caused by or resulting from any variation, interruption, or failure of
Utilities due to any cause whatsoever, or from failure to make any repairs or
perform any maintenance. No temporary interruption or failure of such services
incident to the making of repairs, alterations, improvements, or due to
accident, strike, or conditions or other events shall be deemed an eviction of
Tenant or relieve Tenant from any of its obligations hereunder. In no event
shall Landlord be liable to Tenant for any damage to the Premises or for any
loss, damage or injury to any property therein or thereon occasioned by
bursting, rupture, leakage or overflow of any plumbing or other pipes
(including, without limitation, water, steam, and/or refrigerant lines),
sprinklers, tanks, drains, drinking fountains or washstands, or other similar
cause in, above, upon or about the Premises, the Building, or the Project,
unless caused by Landlord's gross negligence or willful misconduct.

6. LATE CHARGE

        Notwithstanding any other provision of this Lease, Tenant hereby
acknowledges that late payment to Landlord of Rent, or other amounts due
hereunder will cause Landlord to incur costs not contemplated by this Lease, the
exact amount of which will be extremely difficult TO ascertain. If any Rent or
other sums due from Tenant are not received by Landlord or by Landlord's
designated agent when due, then Tenant shall pay to Landlord a late charge equal
to ten percent (10%) of such overdue amount (the "LATE CHARGE"), plus any costs
and reasonable attorneys' fees incurred by Landlord by reason of Tenant's
failure to pay Rent and/or other charges when due hereunder; provided, however,
that Landlord hereby waives its right to collect the first two (2) Late Charges
payable by Tenant hereunder during the Term. Landlord and Tenant hereby agree
that such late charges represent a fair and reasonable estimate of the cost that
Landlord will incur by reason of Tenant's late payment and shall not be
construed as a penalty. Landlord's acceptance of such late charges shall not
constitute a waiver of Tenant's default with respect to such overdue amount or
estop Landlord from exercising any of the other rights and remedies granted
under this Lease.


                     Initials: /s/ JRB            /s/ WGH
                               -----------        -----------
                                Landlord             Tenant

7. SECURITY DEPOSIT

        Prior to Tenant's execution of this Lease, Tenant has deposited with
Landlord the Security Deposit specified in the Basic Lease Information as
security for the full and faithful performance of each and every term, covenant
and condition of this Lease. Landlord may use, apply or retain the whole or any
part of the Security Deposit as may be reasonably necessary (a) to remedy
Tenant's default in the payment of any Rent, (b) to repair damage to the
Premises caused by Tenant, (c) to clean the Premises upon termination of this
Lease, provided that Tenant has, in the reasonable judgment of Landlord, not
cleaned the Premises in accordance with Paragraph 11, (d) to reimburse Landlord
for the payment of any amount which Landlord may reasonably spend or be required
to spend by reason of Tenant's default, or (e) to compensate Landlord for any
other loss or damage which Landlord may suffer by reason of Tenant's default.
Should Tenant


                                       11


<PAGE>
faithfully and fully comply with all of the terms, covenants and conditions of
this Lease, within thirty (30) days following the expiration of the Term, the
Security Deposit or any balance thereof shall be returned to Tenant or, at the
option of Landlord, to the last assignee of Tenant's interest in this Lease.
Landlord shall keep the Security Deposit separate from its general funds and
shall deposit such in a financial institution selected by Landlord and Tenant
shall be entitled to any interest paid by such Bank on the Security Deposit and
such interest shall be paid on an annual basis to Tenant by Landlord
concurrently with the delivery of the Expense Statement or credited against any
amounts owed by Tenant to Landlord as shown on such Expense Statement. If
Landlord so uses or applies all or any portion of said deposit, within five (5)
days after written demand therefor Tenant shall deposit cash with Landlord in an
amount sufficient to restore the Security Deposit to the full extent of the
above amount, and Tenant's failure to do so shall be a default under this Lease.
In the event Landlord transfers its interest in this Lease, Landlord shall
transfer the then remaining amount of the Security Deposit to Landlord's
successor in interest, and thereafter Landlord shall have no further liability
to Tenant with respect to such Security Deposit.

8. POSSESSION

        (a) TENANT'S RIGHT OF POSSESSION. Subject to Paragraph 8(b), Tenant
shall be entitled to possession of the Premises upon commencement of the Term.

        (b) DELAY IN DELIVERING POSSESSION. If for any reason whatsoever,
Landlord cannot deliver possession of the Premises to Tenant on or before the
Estimated Commencement Date, this Lease shall not be void or voidable (except as
otherwise expressly provided in Paragraph 8(c) and (d) below), nor shall
Landlord, or Landlord's agents, advisors, employees, partners, shareholders,
directors, invitees or independent contractors (collectively, "LANDLORD'S
AGENTS"), be liable to Tenant for any loss or damage resulting therefrom.
Subject to Paragraph D OF EXHIBIT B, Tenant shall not be liable for Rent until
Landlord delivers possession of the Premises to Tenant. The Expiration Date
shall be extended by the same number of days that Tenant's possession of the
Premises was delayed beyond the Estimated Commencement Date.

        (c) TIME FOR PERFORMANCE. The parties have set forth on EXHIBIT G
certain events which must occur prior to or during the construction of the Base
Building Improvements (each a "CONDITION"), together with certain dates upon
which each condition must be satisfied ("INITIAL WINDOW DATE"); provided,
however, that if Landlord is delayed in satisfying any Condition due to Tenant
Delays or Force Majeure Events (as defined in EXHIBIT B), all of the Initial
Window Dates set forth on EXHIBIT G shall be extended for a period equal to the
length of such delay. If any condition is not satisfied on or before its
respective Initial Window Date, as the same may be so extended in accordance
with the terms hereof, Tenant shall have the right to terminate this Lease by
delivering written notice to Landlord within five (5) business days after
expiration of the applicable Initial Window Date. If Tenant does not deliver
written notice of termination to Landlord within such five day period, time
being of the essence, Tenant shall have waived its right to terminate as a
result of Landlord's failure to satisfy the particular Condition in question,
and all rights and obligations of Landlord and Tenant shall continue in full
force and effect, including satisfaction of the remaining Conditions. If Tenant
timely elects to terminate this Lease, the Lease shall terminate and the
Security Deposit shall be returned to Tenant.


                                       12


<PAGE>
        (d) OUTSIDE COMPLETION DATE. Notwithstanding anything in this Lease to
the contrary, if Landlord has not obtained a temporary certificate of occupancy
relating to the Base Building Improvements on or before August 1, 2002, either
Tenant or Landlord shall have the right to terminate this Lease by delivering
written notice to the other on or before August 5, 2002; provided, however, that
if Landlord is delayed in obtaining the temporary certificate of occupancy
relating to the Base Building Improvements as a result of Tenant Delays, such
date shall be extended for a period equal to the length of any such Tenant
Delay. If neither party delivers written notice of termination to the other
within such time period, each party shall have waived its right to terminate and
all rights and obligations of Landlord and Tenant shall continue in full force
and effect, including satisfaction of the remaining Conditions. If either Tenant
or Landlord timely elects to terminate this Lease, the Lease shall terminate and
Landlord shall promptly refund to Tenant all sums paid to Landlord by Tenant.

9. USE OF PREMISES

        (a) PERMITTED USE: The use of the Premises by Tenant and Tenant's
agents, advisors, employees, partners, shareholders, directors, invitees and
independent contractors (collectively, "TENANT'S AGENTS") shall be solely for
the Permitted Use specified in the Basic Lease Information and for no other use.
Without limiting the foregoing, Tenant understands and agrees that no
manufacturing activities shall be permitted within the Premises except for the
light manufacturing of individual prototypes of pharmaceutical products created
by Tenant. Tenant shall not permit any objectionable or unpleasant odor, smoke,
dust, gas, noise or vibration to emanate from or near the Premises. The Premises
shall not be used to create any nuisance or trespass, for any illegal purpose,
for any purpose not permitted by Laws, for any purpose that would invalidate the
insurance or increase the premiums for insurance on the Premises, the Building
or the Project or for any purpose or in any manner that would interfere with
other tenants' use or occupancy of the Project. Tenant agrees to pay to
Landlord, as Additional Rent, any increases in premiums on policies resulting
from Tenant's Permitted Use or any other use or action by Tenant or Tenant's
Agents which increases Landlord's premiums or requires additional coverage by
Landlord to insure the Premises. Tenant agrees not to overload the floor(s) of
the Building.

        (b) COMPLIANCE WITH GOVERNMENTAL REGULATIONS AND PRIVATE RESTRICTIONS.
Tenant and Tenant's Agents shall, at Tenant's expense, faithfully observe and
comply with (i) all municipal, state and federal laws, statutes, codes, rules,
regulations, ordinances, requirements, and orders (collectively, "LAWS"), except
such laws applicable to the construction of the Base Building Improvements, now
in force or which may hereafter be in force pertaining to the Premises or
Tenant's use of the Premises, the Building or the Project, including, without
limitation, any Laws requiring installation of fire sprinkler systems, seismic
reinforcement and related alterations, whether substantial in cost or otherwise;
provided, however, that except as provided in Paragraph 9(c) below, Tenant shall
not be required to make or, except as provided in Paragraph 4 above, pay for,
structural changes to the Premises or the Building not related to Tenant's
specific use of the Premises unless the requirement for such changes is imposed
as a result of any improvements or additions made or proposed to be made at
Tenant's request; (ii) all recorded covenants, conditions and restrictions
affecting the Project ("PRIVATE RESTRICTIONS") now in force or which may
hereafter be in force; and (iii) any and all rules and regulations set forth in
Exhibit E and any other rules and regulations now or hereafter promulgated by
Landlord related


                                       13


<PAGE>
to parking or the operation of the Premises, the Building and/or the Project
(collectively, the "RULES AND REGULATIONS"). The judgment of any court of
competent jurisdiction, or the admission of Tenant in any action or proceeding
against Tenant, whether Landlord be a party thereto or not, that Tenant has
violated any such Laws or Private Restrictions, shall be conclusive of that fact
as between Landlord and Tenant.

        (c) COMPLIANCE WITH AMERICANS WITH DISABILITIES ACT. Landlord and Tenant
hereby agree and acknowledge that the Premises, the Building and/or the Project
may be subject to, among other Laws, the requirements of the Americans with
Disabilities Act, a federal law codified at 42 U.S.C. 12101 et seq., including,
but not limited to Title III thereof, and all regulations and guidelines related
thereto, together with any and all laws, rules, regulations, ordinances, codes
and statutes now or hereafter enacted by local or state agencies having
jurisdiction thereof, including all requirements of Title 24 of the State of
California, as the same may be in effect on the date of this Lease and may be
hereafter modified, amended or supplemented (collectively, the "ADA"). Landlord
shall cause the Base Building Improvements to be constructed in compliance with
the ADA. Any Tenant Improvements to be constructed hereunder shall be in
compliance with the requirements of the ADA, and all costs incurred for purposes
of compliance therewith shall be a part of and included in the costs of the
Tenant Improvements. Tenant shall be solely responsible for conducting its own
independent investigation of this matter and for ensuring that the design of all
Tenant Improvements strictly complies with all requirements of the ADA. Subject
to reimbursement pursuant to Paragraph 4 above, if any barrier removal work or
other work is required to the Building, the Common Areas or the Project under
the ADA, then such work shall be the responsibility of Landlord, provided that,
if such work is required under the ADA as a result of Tenant's use of the
Premises or any work or Alteration (as hereinafter defined) made to the Premises
by or on behalf of Tenant, then such work shall be performed by Landlord at the
sole cost and expense of Tenant. Except as otherwise expressly provided in this
provision, Tenant shall be responsible at its sole cost and expense for fully
and faithfully complying with all applicable requirements of the ADA, including,
without limitation, not discriminating against any disabled persons in the
operation of Tenant's business in or about the Premises, and offering or
otherwise providing auxiliary aids and services as, and when, required by the
ADA. Within ten (10) days after receipt, Tenant shall advise Landlord in
writing, and provide Landlord with copies of (as applicable), any notices
alleging violation of the ADA relating to any portion of the Premises, the
Building or the Project; any claims made or threatened orally or in writing
regarding noncompliance with the ADA and relating to any portion of the
Premises, the Building, or the Project; or any governmental or regulatory
actions or investigations instituted or threatened regarding noncompliance with
the ADA and relating to any portion of the Premises, the Building or the
Project. Tenant shall and hereby agrees to protect, defend (with counsel
acceptable to Landlord) and hold Landlord and Landlord's Agents harmless and
indemnify Landlord and Landlord's Agents from and against all liabilities,
damages, claims, losses, penalties, judgments, charges and expenses (including
attorneys' fees, costs of court and expenses necessary in the prosecution or
defense of any litigation including the enforcement of this provision) arising
from or in any way related to, directly or indirectly, Tenant's or Tenant's
Agents' violation or alleged violation of the ADA. Landlord shall and hereby
agrees to protect, defend (with counsel acceptable to Tenant) and hold Tenant
and Tenant's Agents harmless and indemnify Tenant and Tenant's Agents from and
against all liabilities, damages, claims, losses, penalties, judgments, charges
and expenses (including attorneys' fees, costs of court and expenses necessary
in the prosecution or defense of any


                                       14


<PAGE>
litigation including the enforcement of this provision) arising from or in any
way related to, directly or indirectly, Landlord's failure to have the Building
Improvements constructed in compliance with the ADA.

10. ACCEPTANCE OF PREMISES

        By taking possession of the Premises hereunder Tenant accepts the
Premises as suitable for Tenant's intended use and as being in good and sanitary
operating order, condition and repair, AS IS, and without representation or
warranty by Landlord as to the condition, use or occupancy which may be made
thereof, except for Landlord's express obligations described in Exhibit A. Any
exceptions to the foregoing must be by written agreement executed by Landlord
and Tenant.

11. SURRENDER

        (a) Tenant agrees that on the last day of the Term, or on the sooner
termination of this Lease, Tenant shall surrender the Premises to Landlord (i)
in good condition and repair (damage by acts of God, fire, and normal wear and
tear excepted), but with all interior walls painted or cleaned so they appear
painted and, where appropriate, patched, any carpets cleaned, all floors cleaned
and waxed, and all plumbing fixtures in good condition and working order and,
where appropriate, capped, and (ii) otherwise in accordance with Paragraph
32(h). Normal wear and tear shall not include any damage or deterioration that
would have been prevented by proper maintenance by Tenant, or Tenant otherwise
performing all of its obligations under this Lease. On or before the expiration
or sooner termination of this Lease, Tenant shall, in accordance with this
Paragraph 11, and at Tenant's sole cost and expense, remove, and repair any
damage caused by such removal, (A) all of Tenant's Property (as hereinafter
defined) and Tenant's signage from the Premises, the Building and the Project
and (B) all Tenant Improvements and all Alterations required to be removed
pursuant to Paragraph 12 and Exhibit B. Any of Tenant's Property not so removed
by Tenant as required herein shall be deemed abandoned and may be stored,
removed, and disposed of by Landlord at Tenant's expense, and Tenant waives all
claims against Landlord for any damages resulting from Landlord's retention and
disposition of such property; provided, however, that Tenant shall remain liable
to Landlord for all costs incurred in storing and disposing of such abandoned
property of Tenant. All Tenant Improvements and Alterations except those which
Tenant is required to remove pursuant to Paragraph 12 and Exhibit B shall remain
in the Premises as the property of Landlord. If the Premises are not surrendered
at the end of the Term or sooner termination of this Lease, and in accordance
with the provisions of this Paragraph 11 and Paragraph 32(h) below, Tenant shall
indemnify, defend and hold Landlord harmless from and against any and all loss
or liability resulting from delay by Tenant in so surrendering the Premises
including, without limitation, any loss or liability resulting from any claim
against Landlord made by any succeeding tenant or prospective tenant founded on
or resulting from such delay and losses to Landlord due to lost opportunities to
lease any portion of the Premises to any such succeeding tenant or prospective
tenant, together with, in each case, actual attorneys' fees and costs.


                                       15


<PAGE>
        (b) Notwithstanding Paragraph 11 (a) above, with respect to all R&D
Space, as defined below, within the Premises, Tenant shall, on the last day of
the Term or on the sooner termination of this Lease, surrender such space to
Landlord as follows:

               (i) The Allowable R&D Space, as defined below, shall be
surrendered to Landlord in the condition specified in clauses (i) and (ii) of
Paragraph 11 (a) above, except that Tenant shall not be required to paint or
patch any interior walls located within the Allowable R&D Space.

               (ii) The Additional R&D Space, as defined below, shall be
surrendered to Landlord in the condition specified in clauses (i) and (ii) of
Paragraph 11 (a) above. In addition, Tenant shall pay to Landlord on or before
the last day of the Term or on the sooner termination of this Lease, the costs,
as reasonably determined by Landlord, necessary to remove all Tenant
Improvements and Alterations required to be removed under Paragraph 12 and
EXHIBIT B, and otherwise to surrender the Premises in a condition ready for
Landlord to commence build-out of such space for a succeeding tenant.

        (c) For the purposes of this Paragraph 11, the following definitions
shall apply:

               (i) ALLOWABLE R&D SPACE shall mean that portion of R&D Space
within the Premises that, in the aggregate, does not exceed ten thousand
(10,000) square feet, the location of which shall be reasonably designated by
Landlord in a notice to Tenant given not later than ninety (90) days prior to
the Expiration Date (except in the event of a termination of this Lease prior to
the scheduled Expiration Date, in which event, no advance notice shall be
required).

               (ii) ADDITIONAL R&D SPACE shall mean that portion of R&D Space
within the Premises in excess of the maximum Allowable R&D Space under Paragraph
11(c)(i) above, provided that the Additional R&D Space shall not exceed an
aggregate of fifteen thousand eighty (15,080) square feet. The location of the
Additional R&D Space shall be reasonably designated by Landlord in a notice to
Tenant given not later than ninety (90) days prior to the Expiration Date
(except in the event of a termination of this Lease prior to the scheduled
Expiration Date, in which event, no advance notice shall be required).

               (iii) R&D SPACE shall mean space that has been improved for
research and development, product development, light prototype manufacturing,
engineering, evaluation and testing activities and that, without
reconfiguration, cannot be used for standard office use, all as determined by
Landlord in its reasonable discretion based upon market conditions generally
existing at the time.

        (d) Notwithstanding anything in this Lease to the contrary, in no event
shall the R&D Space comprise, at any time during the Term, more than twenty-five
thousand eighty (25,080) square feet.

12. ALTERATIONS AND ADDITIONS

        (a) Tenant shall not make, or permit to be made, any alteration,
addition or improvement (hereinafter referred to individually as an "ALTERATION"
and collectively as the "ALTERATIONS") to the Premises or any part thereof
without the prior written consent of Landlord, which consent shall not be
unreasonably withheld, conditioned or delayed; provided, however, that Landlord
shall


                                       16


<PAGE>
have the right in its sole and absolute discretion to consent or to withhold its
consent to any Alteration which affects the structural portions of the Premises,
the Building or the Project or the mechanical, electrical or life-safety systems
serving the Premises the Building and/or the Project or any portion thereof (the
"SYSTEMS"). Notwithstanding the foregoing, but subject to the conditions set
forth below, Tenant may, without Landlord's consent, make Alterations within the
Premises, provided that such Alterations (i) do not affect the structural
portions of the Premises, the Building or the Project or the Systems, (ii) the
cost, on an individual project basis, of any Alteration is less than $50,000.00
and, in the aggregate for the Term, does not exceed $500,000.00, and (iii) will
not cause the R&D Space within the Premises to comprise more than twenty-five
thousand eighty (25,080) square feet in the aggregate.

        (b) Any Alteration to the Premises shall be at Tenant's sole cost and
expense, in compliance with all applicable Laws and all requirements requested
by Landlord, including, without limitation, the requirements of any insurer
providing coverage for the Premises or the Project or any part thereof, and in
accordance with plans and specifications approved in writing by Landlord, which
approval shall not be unreasonably withheld, conditioned or delayed.
Notwithstanding the foregoing, with respect to Alterations that may be made
without Landlord's prior consent as permitted above, Landlord agrees that Tenant
shall not be required to submit plans and specifications for prior approval of
the Landlord and that Landlord shall not require prior approval of the
installing contractor; provided, however, that if Tenant does not obtain the
prior approval of plans and specifications for any Alteration, then subject to
the terms of this Paragraph 12(b), Landlord may, by notice to Tenant given not
later than ninety (90) days prior to the Expiration Date (except in the event of
a termination of this Lease prior to the scheduled Expiration Date, in which
event no advance notice shall be required), require Tenant, at Tenant's expense,
to remove, and repair any damage caused by removal of, any and all such
Alterations. If Tenant does not obtain Landlord's prior consent as to the
installing contractor, Tenant shall be responsible for maintaining harmonious
labor relations with all contractors and service providers servicing the
Premises, Building and/or Project. In addition, with respect to any Alterations
made without Landlord's prior consent as permitted above, Tenant agrees to meet
with Landlord, at Landlord's request, not more than once in every calendar year,
to discuss any such Alterations that have been made to the Premises. In such
meeting, Tenant shall provide Landlord with "as built" plans and, if requested
by Tenant, Landlord shall within 30 days of such meeting, provide Tenant with a
list of those Alterations reviewed by Landlord that will be required to be
removed upon termination of the Lease. Any Alterations requiring the prior
consent of Landlord shall contain a request that Landlord specify in writing to
Tenant those Alterations that Tenant will be required to remove in accordance
with Paragraph 11 (a) upon expiration or sooner termination of this Lease. Upon
receipt of such request, Landlord shall make such determination and respond to
Tenant within five (5) business days of such request. Before Alterations may
begin, valid building permits or other permits or licenses required must be
furnished to Landlord, and, once the Alterations begin, Tenant will diligently
and continuously pursue their completion. Landlord may monitor construction of
the Alterations and Tenant shall reimburse Landlord for its costs (including,
without limitation, the costs of any construction manager retained by Landlord)
in reviewing plans and documents and in monitoring construction. Tenant shall
maintain during the course of construction, at its sole cost and expense,
builders' risk insurance for the amount of the completed value of the
Alterations on an all-risk non-reporting form covering all improvements under
construction, including building materials, and other insurance in amounts and
against such risks as Landlord shall reasonably require in connection with the
Alterations. In addition to


                                       17


<PAGE>
and without limitation on the generality of the foregoing, Tenant shall ensure
that its contractor(s) procure and maintain in full force and effect during the
course of construction a "broad form" commercial general liability and property
damage policy of insurance naming Landlord, Tenant and Landlord's lenders as
additional insureds. The minimum limit of coverage of the aforesaid policy shall
be in the amount of not less than Three Million Dollars ($3,000,000.00) for
injury or death of one person in any one accident or occurrence and in the
amount of not less than Three Million Dollars ($3,000,000.00) for injury or
death of more than one person in any one accident or occurrence, and shall
contain a severability of interest clause or a cross liability endorsement. Such
insurance shall further insure Landlord and Tenant against liability for
property damage of at least One Million Dollars ($1,000,000.00).

        (c) Except as otherwise expressly stated herein or agreed to between the
parties, all Alterations, including, but not limited to, heating, lighting,
electrical, air conditioning, fixed partitioning, drapery, wall covering and
paneling, built-in cabinet work and carpeting installations made by Tenant,
together with all property that has become an integral part of the Premises or
the Building, shall at once be and become the property of Landlord, and shall
not be deemed trade fixtures or Tenant's Property.

        (d) No private telephone systems, utilities and/or other related
computer, utility or telecommunications equipment or lines may be installed
without Landlord's prior written consent, which consent shall not be
unreasonably withheld, conditioned or delayed. If Landlord gives such consent,
all equipment must be installed within the Premises and, unless Landlord, at the
time of installation, notified Tenant in writing that removal would not be
required, removed upon the expiration or sooner termination of this Lease and
the Premises restored to the same condition as before such installation.

        (e) Notwithstanding anything herein to the contrary, before installing
any equipment or lights which generate an undue amount of heat in the Premises,
or if Tenant plans to use any high-power usage equipment in the Premises, Tenant
shall obtain the written permission of Landlord which permission shall not be
unreasonably withheld, conditioned or delayed. Landlord may refuse to grant such
permission unless Tenant agrees to pay the costs to Landlord for installation of
supplementary air conditioning capacity or electrical systems necessitated by
such equipment.

        (f) Tenant agrees not to proceed to make any Alterations,
notwithstanding consent from Landlord to do so, until Tenant notifies Landlord
in writing of the date Tenant desires to commence construction or installation
of such Alterations and Landlord has approved such date in writing, in order
that Landlord may post appropriate notices to avoid any liability to contractors
or material suppliers for payment for Tenant's improvements. Tenant will at all
times permit such notices to be posted and to remain posted until the completion
of work.

        (g) Notwithstanding any provision of this Lease to the contrary,
including, without limitation, any provision of Paragraph 12(a) above which
provides that Landlord shall not unreasonably withhold its consent to the making
of certain Alterations, Tenant understands and agrees that at no time during the
Term shall the R&D Space comprise, in the aggregate, more than twenty-five
thousand eighty (25,080) square feet of the Premises and that Landlord shall
have the right, in its sole and absolute discretion, to deny or withhold its
consent to any


                                       18


<PAGE>
Alterations that would cause the aggregate R&D Space within the Premises to
exceed the foregoing limitation.

13. MAINTENANCE AND REPAIRS OF PREMISES

        (a) MAINTENANCE BY TENANT. Throughout the Term, Tenant shall, at its
sole expense, (i) keep and maintain in good order and condition the Premises,
and repair and replace every part thereof, including interior glass, windows,
window frames and casements, interior doors and door frames and door closers;
interior lighting (including, without limitation, light bulbs and ballasts), the
heating, ventilating and air conditioning, plumbing, electrical and life safety
systems exclusively serving the Premises, all communications systems serving the
Premises, signage, interior demising walls and partitions, equipment, interior
painting and interior walls and floors, and the roll-up doors, ramps and dock
equipment, including, without limitation, dock bumpers, dock plates, dock seals,
dock levelers and dock lights located in or on the Premises (excepting only
those portions of the Building or the Project to be maintained by Landlord, as
provided in Paragraph 13(b) below), (ii) furnish all expendables, including
tight bulbs, paper goods and soaps, used in the Premises, and (iii) keep and
maintain in good order sad condition, repair and replace all of Tenant's
security systems in or about or serving the Premises. Tenant shall not do nor
shall Tenant allow Tenant's Agents to do anything to cause any damage,
deterioration or unsightliness to the Premises, the Building or the Project.
Without limiting Tenant's obligations under this Paragraph 13(a), Tenant shall,
at a minimum, observe and follow Landlord's standard servicing guidelines for
the heating, ventilating and air conditioning, plumbing, electrical and life
safety systems serving the Premises.

        (b) MAINTENANCE BY LANDLORD. Subject to the provisions of Paragraphs
13(a), 21 and 22, and further subject to Tenant's obligation under Paragraph 4
to reimburse Landlord, in the form of Additional Rent, for Tenant's
Proportionate Share of the Project and the Building, as applicable, of the cost
and expense of the following items, Landlord agrees to repair and maintain the
following items: exterior glass, windows, window frames and casements, exterior
doors and door frames and door closers; the roof coverings (provided that Tenant
installs no additional air conditioning or other equipment on the roof that
damages the roof coverings, in which event Tenant shall pay all costs resulting
from the presence of such additional equipment); the Systems serving the
Premises and the Building, excluding the heating, ventilating and air
conditioning, plumbing, electrical and life safety systems exclusively serving
the Premises; and the Parking Areas, pavement, landscaping, sprinkler systems,
sidewalks, driveways, curbs, and lighting systems in the Common Areas. Subject
to the provisions of Paragraphs 13(a), 21 and 22, Landlord, at its own cost and
expense, agrees to repair and maintain the following items: the structural
portions of the roof (specifically excluding the roof coverings), the
foundation, the footings, the floor slab, and the load bearing walls and
exterior walls of the Building (excluding any glass and any routine maintenance,
including, without limitation, any painting, sealing, patching and waterproofing
of such walls). Notwithstanding anything in this Paragraph 13 to the contrary,
Landlord shall have the right to either repair or to require Tenant to repair
any damage to any portion of the Premises, the Building and/or the Project
caused by or created due to any act, omission negligence or willful misconduct
of Tenant or Tenant's Agents and to restore the Premises, the Building and/or
the Project, as applicable, to the condition existing prior to the occurrence of
such damage; provided, however, that in the event Landlord elects to perform
such repair and restoration work, Tenant shall reimburse Landlord upon demand
for all costs and


                                       19


<PAGE>
expenses incurred by Landlord in connection therewith. Landlord's obligation
hereunder to repair and maintain is subject to the condition precedent that
Landlord shall have received written notice of the need for such repairs and
maintenance and a reasonable time to perform such repair and maintenance. Tenant
shall promptly report in writing to Landlord any defective condition known to it
which Landlord is required to repair, and failure to so report such defects
shall make Tenant responsible to Landlord for any liability incurred by Landlord
by reason of such condition.

        (c) TENANT'S WAIVER OF RIGHTS. Tenant hereby expressly waives all rights
to make repairs at the expense of Landlord or to terminate this Lease, as
provided for in California Civil Code Sections 1941 and 1942, and 1932(1),
respectively, and any similar or successor statute or law in effect or any
amendment thereof during the Term.

14. LANDLORD'S INSURANCE

        Landlord shall purchase and keep in force "all risk" property insurance
covering the Building and the Project. Tenant shall, at its sole cost and
expense, comply with any and all reasonable requirements pertaining to the
Premises, the Building and the Project of any insurer necessary for the
maintenance of reasonable fire and commercial general liability insurance,
covering the Building and the Project. Landlord, at Tenant's cost, may maintain
"Loss of Rents" insurance, insuring that the Rent will be paid in a timely
manner to Landlord for a period of at least twelve (12) months if the Premises,
the Building or the Project or any portion thereof are destroyed or rendered
unusable or inaccessible by any cause insured against under this Lease.
Notwithstanding the foregoing, in the event Tenant provides satisfactory
evidence to Landlord that Tenant maintains insurance reasonably acceptable to
Landlord insuring that the Rent will be paid in a timely manner to Landlord for
a period of at least twelve (12) months if the Premises, the Building or the
Project or any portion thereof are destroyed or rendered unusable or
inaccessible by any cause insured against under this Lease, Landlord will not
charge Tenant for the cost of maintaining "Loss of Rents" insurance; provided,
however, that if for any reason Tenant fails to maintain such insurance, Tenant
shall be responsible for payment of the Rent that would have been paid to
Landlord had Tenant maintained insurance for such lost Rent.

15. TENANT'S INSURANCE

        (a) COMMERCIAL GENERAL LIABILITY INSURANCE. Tenant shall, at Tenant's
expense, secure and keep in force a Commercial General Liability insurance
policy covering the Premises, insuring Tenant, and naming Landlord and its
lenders as additional insureds, against liability arising out of the ownership,
use, occupancy or maintenance of the Premises. The minimum limit of coverage of
such policy shall be in the amount of not less than Three Million Dollars
($3,000,000.00) for each occurrence combined single limited for bodily injury
and property damage, shall include an extended liability endorsement providing
contractual liability coverage (which shall include coverage for Tenant's
indemnification obligations in this Lease), and shall contain a severability of
interest clause or a cross liability endorsement. Landlord may from time to time
require reasonable increases in any such limits if Landlord believes that
additional coverage is necessary or desirable. The limit of any insurance 'shall
not limit the liability of Tenant hereunder. No policy maintained by Tenant
under this Paragraph 15(a) shall contain a deductible greater than One Hundred
Thousand Dollars ($100,000.00). No policy shall be


                                       20


<PAGE>
cancelable without thirty (30) days prior written notice to Landlord. Such
policies of insurance shall be issued as primary policies and not contributing
with or in excess of coverage that Landlord may carry, by an insurance company
authorized to do business in the State of California for the issuance of such
type of insurance coverage and rated A:XIII or better in Best's Key Rating
Guide.

        (b) PERSONAL PROPERTY INSURANCE. Tenant shall maintain in full force and
effect on all of its personal property, furniture, furnishings, trade or
business fixtures, equipment and such other items listed on Exhibit H
(collectively, "TENANT'S PROPERTY") located on the Premises, a policy or
policies of fire and extended coverage insurance with water damage and sprinkler
leakage coverage to the extent of the full replacement cost thereof. No such
policy shall contain a deductible greater than One Hundred Thousand Dollars
($100,000.00). During the term of this Lease the proceeds from any such policy
or policies of insurance shall be used for the repair or replacement of the
fixtures and equipment so insured. Landlord shall have no interest in the
insurance upon Tenant's equipment and fixtures and will sign all documents
reasonably necessary in connection with the settlement of any claim or loss by
Tenant. Landlord will not carry insurance on Tenant's possessions.

        (c) WORKER'S COMPENSATION INSURANCE; EMPLOYER'S LIABILITY INSURANCE.
Tenant shall, at Tenant's expense, maintain in fill force and effect worker's
compensation insurance with not less than the minimum limits required by law,
and employer's liability insurance with a minimum limit of coverage of One
Million Dollars ($1,000,000.00).

        (d) EVIDENCE OF COVERAGE. Tenant shall deliver to Landlord certificates
of insurance and true and complete copies of any and all endorsements required
herein for all insurance required to be maintained by Tenant hereunder at the
time of execution of this Lease by Tenant. Tenant shall, at least thirty (30)
days prior to expiration of each policy, furnish Landlord with certificates of
renewal or "binders" thereof. Each certificate shall expressly provide that such
policies shall not be cancelable except after thirty (30) days prior written
notice to Landlord and the other parties named as additional insureds as
required in this Lease (except for cancellation for nonpayment of premium, in
which event cancellation shall not take effect until at least ten (10) days
notice has been given to Landlord).

16. INDEMNIFICATION

        (a) OF LANDLORD Tenant shall indemnify and hold harmless Landlord and
Landlord's Agents against and from any and all claims, liabilities, judgments,
costs, demands, causes of action and expenses (including, without limitation,
reasonable attorneys' fees) arising from (i) the use of the Premises, the
Building or the Project by Tenant or Tenant's Agents, or from any activity done,
permitted or suffered by Tenant or Tenant's Agents in or about the Premises, the
Building or the Project, and (ii) any act, neglect, fault, willful misconduct or
omission of Tenant or Tenant's Agents, or from any breach or default in the
terms of this Lease by Tenant or Tenant's Agents, and (iii) any action or
proceeding brought on account of any matter in items (i) or (ii). If any action
or proceeding is brought against Landlord by reason of any such claim, upon
notice from Landlord, Tenant shall defend the same at Tenant's expense by
counsel reasonably satisfactory to Landlord. As a material part of the
consideration to Landlord, Tenant hereby releases Landlord and Landlord's Agents
from responsibility for, waives its entire claim


                                       21


<PAGE>
of recovery for and assumes all risk of (A) damage to property or injury to
persons in or about the Premises, the Building or the Project from any cause
whatsoever (except that which is caused by the gross negligence or willful
misconduct of Landlord or Landlord's Agents or by the failure of Landlord to
observe any of the terms and conditions of this Lease, if such failure has
persisted for an unreasonable period of time after written notice of such
failure), or (B) loss resulting from business interruption or loss of income at
the Premises. The obligations of Tenant under this Paragraph 16 shall survive
any termination of this Lease.

        (b) OF TENANT. Landlord shall indemnify and hold harmless Tenant and
Tenant's Agents against and from any and all claims, liabilities, judgments,
costs, demands, causes of action and expenses (including, without limitation,
reasonable attorneys' fees) relating to the Project and arising from the gross
negligence or willful misconduct of Landlord or Landlord's Agents, and any
action or proceeding brought on account of such claims. If any action or
proceeding is brought against Tenant by reason of any such claim, upon notice
from Tenant, Landlord shall defend the same at Landlord's expense by counsel
reasonably satisfactory to Landlord. The obligations of Landlord under this
Paragraph 16 shall survive any termination of this Lease.

        (C) NO IMPAIRMENT OF INSURANCE. The foregoing indemnity shall not
relieve any insurance carrier of its obligations under any policies required to
be carried by either party pursuant to this Lease, to the extent that such
policies cover the peril or occurrence that results in the claim that is subject
to the foregoing indemnity.

17. SUBROGATION

        Landlord and Tenant hereby mutually waive any claim against the other
and its Agents for any loss or damage to any of their property located on or
about the Premises, the Building or the Project that is caused by or results
from perils covered by the property insurance required to be carried by the
respective parties in accordance with Paragraphs 14 and 15 of this Lease,
whether or not due to the negligence of the other party or its Agents. Because
the foregoing waivers will preclude the assignment of any claim by way of
subrogation to an insurance company or any other person, each party now agrees
to immediately give to its insurer written notice of the terms of these mutual
waivers and shall have their insurance policies endorsed to prevent the
invalidation of the insurance coverage because of these waivers. Nothing in this
Paragraph 17 shall relieve a party of liability to the other for failure to
carry insurance required by this Lease.

18. SIGNS

        Landlord shall install, at Landlord's expense, building signage
reflecting Tenant's occupancy of the Premises mutually acceptable to Landlord
and Tenant and complying with all applicable Laws and all covenants, conditions
and restrictions affecting the Project. In addition to the foregoing building
signage, Landlord shall post the address of the Building on the monument sign
currently existing on the Project. Tenant shall not place or permit to be placed
in, upon, or about the Premises, the Building or the Project any exterior
lights, decorations, balloons, flags, pennants, banners, advertisements or
notices, or erect or install any signs, windows or door lettering, placards,
decorations, or advertising media of any type which can be viewed from the
exterior the Premises without obtaining Landlord's prior written consent.


                                       22


<PAGE>
19. FREE FROM LIENS

        Tenant shall keep the Premises, the Building and the Project free from
any liens arising out of any work performed, material furnished or obligations
incurred by or for Tenant in accordance with the provisions of this Paragraph
19. In the event that Tenant shall not, within ten (10) days following the
imposition of any such lien, cause the lien to be released of record by payment
or posting of a proper bond, Landlord shall have in addition to all other
remedies provided herein and by law the right but not the obligation to cause
same to be released by such means as it shall deem proper, including payment of
the claim giving rise to such lien. All such sums paid by Landlord and all
expenses incurred by it in connection therewith (including, without limitation,
attorneys' fees) shall be payable to Landlord by Tenant upon demand. Landlord
shall have the right at all times to post and keep posted on the Premises any
notices permitted or required by law or that Landlord shall deem proper for the
protection of Landlord, the Premises, the Building and the Project, from
mechanics' and materialmen's liens. Tenant shall give to Landlord at least five
(5) business days' prior written notice of commencement of any repair or
construction on the Premises.

20. ENTRY BY LANDLORD

        Tenant shall permit Landlord and Landlord's Agents to enter into and
upon the Premises at all reasonable times, upon reasonable notice (except in the
case of an emergency, for which no notice shall be required), and subject to
Tenant's reasonable security arrangements, for the purpose of inspecting the
same or showing the Premises to prospective purchasers, lenders or tenants or to
alter, improve, maintain anti repair the Premises or the Building as required or
permitted of Landlord under the terms hereof, or for any other business purpose,
without any rebate of Rent and without any liability to Tenant for any loss of
occupation or quiet enjoyment of the Premises thereby occasioned (except for
actual damages resulting from the gross negligence or willful misconduct of
Landlord); and Tenant shall permit Landlord to post notices of
non-responsibility and ordinary "for sale" or "for lease" signs. No such entry
shall be construed to be a forcible or unlawful entry into, or a detainer of,
the Premises, or an eviction of Tenant from the Premises. Landlord may
temporarily close entrances, doors, corridors, elevators or other facilities
without liability to Tenant by reason of such closure in the case of an
emergency and when Landlord otherwise reasonably deems such closure necessary.

21. DESTRUCTION AND DAMAGE

        (a) If the Premises are damaged by fire or other perils covered by
extended coverage insurance, Landlord shall, at Landlord's option:

               (i) In the event of total destruction (which shall mean
destruction or damage in excess of twenty-five percent (25%) of the full
insurable value thereof) of the Premises, elect either to commence promptly to
repair and restore the Premises and prosecute the same diligently to completion,
in which event this Lease shall remain in full force and effect; or not to
repair or restore the Premises, in which event this Lease shall terminate.
Landlord shall give Tenant written notice of its intention within sixty (60)
days after the date (the "CASUALTY DISCOVERY Date") Landlord obtains actual
knowledge of such destruction. If Landlord elects not to restore


                                       23


<PAGE>
the Premises, this Lease shall be deemed to have terminated as of the date of
such total destruction.

               (ii) In the event of a partial destruction (which shall mean
destruction or damage to an extent not exceeding twenty-five percent (25%) of
the full insurable value thereof) of the Premises for which Landlord will
receive insurance proceeds sufficient to cover the cost to repair and restore
such partial destruction and, if the damage thereto is such that the Premises
may be substantially repaired or restored to its condition existing immediately
prior to such damage or destruction within one hundred eighty (180) days from
the Casualty Discovery Date, Landlord shall commence and proceed diligently with
the work of repair and restoration, in which event the Lease shall continue in
full force and effect. If such repair and restoration requires longer than one
hundred eighty (180) days or if the insurance proceeds therefor (plus any
amounts Tenant may elect or is obligated to contribute) are not sufficient to
cover the cost of such repair and restoration, Landlord may elect either to so
repair and restore, in which event the Lease shall continue in full force and
effect, or not to repair or restore, in which event the Lease shall terminate.
In either case, Landlord shall give written notice to Tenant of its intention
within sixty (60) days after the Casualty Discovery Date. If Landlord elects not
to restore the Premises, this Lease shall be deemed to have terminated as of the
date of such partial destruction.

        (b) If the Premises are damaged by any peril not covered by extended
coverage insurance, and the cost to repair such damage exceeds any amount Tenant
may agree to contribute, Landlord may elect either to commence promptly to
repair and restore the Premises and prosecute the same diligently to completion,
in which event this Lease shall remain in full force and effect; or not to
repair or restore the Premises, in which event this Lease shall terminate.
Landlord shall give Tenant written notice of its intention within sixty (60)
days after the Casualty Discovery Date. If Landlord elects not to restore the
Premises, this Lease shall be deemed to have terminated as of the date on which
Tenant surrenders possession of the Premises to Landlord, except that if the
damage to the Premises materially impairs Tenant's ability to continue its
business operations in the Premises, then this Lease shall be deemed to have
terminated as of the date such damage occurred.

        (c) Notwithstanding anything to the contrary in this Paragraph 21,
Landlord shall have the option to terminate this Lease, exercisable by notice to
Tenant within sixty (60) days after the Casualty Discovery Date, in each of the
following instances:

               (i) If more than twenty-five percent (25%) of the full insurable
value of the Building is damaged or destroyed, regardless of whether or not the
Premises are destroyed.

               (ii) If the Building or the Project or any portion thereof is
damaged or destroyed and the repair and restoration of such damage requires
longer than one hundred eighty (180) days from the Casualty Discovery Date.

               (iii) If the Building or the Project or any portion thereof is
damaged or destroyed and the insurance proceeds therefor are not sufficient to
cover the costs of repair and restoration.

               (iv) If the Building or the Project or any portion thereof is
damaged or destroyed during the last twelve (12) months of the Term.


                                       24


<PAGE>
        (d) In the event of repair and restoration as herein provided, the
monthly installments of Base Rent shall be abated proportionately in the ratio
which Tenant's use of the Premises is impaired during the period of such repair
or restoration, but only to the extent of rental abatement insurance proceeds
received by Landlord; provided, however, that Tenant shall not be entitled to
such abatement to the extent that such damage or destruction was caused by the
acts or inaction of Tenant or Tenant's Agents. The number of parking spaces
allocated to Tenant hereunder shall be reduced on a proportionate basis in the
event any of the parking spaces in the Parking Areas are eliminated as a result
of such damage or destruction affecting such Parking Areas. Except as expressly
provided in the immediately preceding sentence with respect to abatement of Base
Rent, Tenant shall have no claim against Landlord for, and hereby releases
Landlord and Landlord's Agents from responsibility for and waives its entire
claim of recovery for any cost, loss or expense suffered or incurred by Tenant
as a result of any damage to or destruction of the Premises, the Building or the
Project or the repair or restoration thereof, including, without limitation, any
cost, loss or expense resulting from any loss of use of the whole or any part of
the Premises, the Building or the Project and/or any inconvenience or annoyance
occasioned by such damage, repair or restoration unless caused by the gross
negligence or willful misconduct of Landlord.

        (e) If Landlord is obligated to or elects to repair or restore as herein
provided, Landlord shall repair or restore only the initial Tenant Improvements
constructed in the Premises pursuant to the terms of this Lease, substantially
to their condition existing immediately prior to the occurrence of the damage or
destruction; and Tenant may, but shall not be obligated to, promptly repair and
restore, at Tenant's expense, Tenant's Alterations which were not constructed by
Landlord.

        (f) Tenant hereby waives the provisions of California Civil Code Section
1932(2) and Section 1933(4) which permit termination of a lease upon destruction
of the leased premises, and the provisions of any similar law now or hereinafter
in effect, and the provisions of this Paragraph 21 shall govern exclusively in
case of such destruction.

        (g) If Landlord elects to repair or restore the Premises in accordance
with the terms and conditions set forth in this Paragraph 21 but fails to
substantially complete such repair or restoration within two hundred and seventy
(270) days after the Casualty Discovery Date (the "Repair Period") and such
damage to the Premises materially and adversely affects Tenant in the conduct of
its business operations, Tenant shall have the right to terminate this Lease by
providing written notice to Landlord within five (5) business days after the end
of the Repair Period, in which event this Lease shall terminate as of the date
of such casualty.

22. CONDEMNATION

        (a) If twenty-five percent (25%) or more of the Premises or the Building
or the parking areas for the Building as shown on the Site Plan is taken for any
public or quasi-public purpose by any lawful governmental power or authority, by
exercise of the right of appropriation, inverse condemnation, condemnation or
eminent domain, or sold to prevent such taking (each such event being referred
to as a "Condemnation"), Landlord may, at its option, terminate this Lease as of
the date title vests in the condemning party. If twenty-five percent (25%) or
more of the Premises is taken and if the Premises remaining after such
Condemnation and any repairs by


                                       25


<PAGE>
Landlord would materially and adversely affect Tenant in the conduct of its
business operations, Tenant shall have the right to terminate this Lease as of
the date title vests in the condemning party. If either party elects to
terminate this Lease as provided herein, such election shall be made by written
notice to the other party given within thirty (30) days after the nature and
extent of such Condemnation have been finally determined. If neither Landlord
nor Tenant elects to terminate this Lease to the extent permitted above,
Landlord shall promptly proceed to restore the Premises, to the extent of any
Condemnation award received by Landlord, to substantially the same condition as
existed prior to such Condemnation, allowing for the reasonable effects of such
Condemnation, and a proportionate abatement shall be made to the Base Rent
corresponding to the time during which, and to the portion of the floor area of
the Premises (adjusted for any increase thereto resulting from any
reconstruction) of which, Tenant is deprived on account of such Condemnation and
restoration, as reasonably determined by Landlord. In addition, the number of
parking spaces allocated to Tenant hereunder shall be reduced on a proportionate
basis in the event any of the parking spaces in the Parking Areas are taken or
otherwise eliminated as a result of any Condemnation affecting such Parking
Areas. Except as expressly provided in the immediately preceding sentence with
respect to abatement of Base Rent, Tenant shall have no claim against Landlord
for, and hereby releases Landlord and Landlord's Agents from responsibility for
and waives its entire claim of recovery for any cost, loss or expense suffered
or incurred by Tenant as a result of any Condemnation or the repair or
restoration of the Premises, the Building or the Project or the parking areas
for the Building or the Project following such Condemnation, including, without
limitation, any cost, loss or expense resulting from any loss of use of the
whole or any part of the Premises, the Building, the Project or the parking
areas and/or any inconvenience or annoyance occasioned by such Condemnation,
repair or restoration. The provisions of California Code of Civil Procedure
Section 1265.130, which allows either party to petition the Superior Court to
terminate the Lease in the event of a partial taking of the Premises, the
Building or the Project or the parking areas for the Building or the Project,
and any other applicable law now or hereafter enacted, are hereby waived by
Tenant.

        (b) Landlord shall be entitled to any and all compensation, damages,
income, rent, awards, or any interest therein whatsoever which may be paid or
made in connection with any Condemnation, and Tenant shall have no claim against
Landlord for the value of any unexpired term of this Lease or otherwise;
provided, however, that Tenant shall be entitled to receive any award separately
allocated by the condemning authority to Tenant for Tenant's relocation expenses
or the value of Tenant's Property (specifically excluding fixtures, Alterations
and other components of the Premises which under this Lease or by law are or at
the expiration of the Term will become the property of Landlord), provided that
such award does not reduce any award otherwise allocable or payable to Landlord.

23. ASSIGNMENT AND SUBLETTING

        (a) Except as specifically provided for in (b) below, Tenant shall not
voluntarily or by operation of law, (i) mortgage, pledge, hypothecate or
encumber this Lease or any interest herein, (ii) assign or transfer this Lease
or any interest herein, sublease the Premises or any part thereof, or any right
or privilege appurtenant thereto, or allow any other person (the employees and
invitees of Tenant excepted) to occupy or use the Premises, or any portion
thereof, without first obtaining the written consent of Landlord, which consent
shall not be unreasonably


                                       26


<PAGE>
withheld, conditioned or delayed, provided that Tenant is not then in Default
under this Lease nor is any event then occurring which with the giving of notice
or the passage of time, or both, would constitute a Default hereunder. When
Tenant requests Landlord's consent to such assignment or subletting, it shall
notify Landlord in writing of the name and address of the proposed assignee or
subtenant and the nature and character of the business of the proposed assignee
or subtenant and shall provide current and prior financial statements for the
proposed assignee or subtenant prepared in accordance with generally accepted
accounting principles, consistently applied. Tenant shall also provide Landlord
with a copy of the proposed sublease or assignment agreement, including all
material terms and conditions thereof. In the event Tenant wishes to assign or
sublet the entire Premises for the remainder of the Term (except in either event
in connection with a Permitted Transfer) Landlord shall have the option, to be
exercised within thirty (30) days of receipt of the foregoing, to (A) terminate
this Lease in its entirety, (B) sublease or take an assignment, as the case may
be, from Tenant of the interest, in this Lease and/or the Premises that Tenant
proposes to assign or sublease, on the same terms and conditions as stated in
the proposed sublet or assignment agreement, (C) consent to the proposed
assignment or sublease, or (D) refuse its consent to the proposed assignment or
sublease, providing that such consent shall not be unreasonably withheld,
conditioned or delayed so long as Tenant is not then in Default under this Lease
nor is any event then occurring which with the giving of notice or the passage
of time, or both, would constitute a Default hereunder. In the event Landlord
elects to terminate this Lease or sublease or take an assignment from Tenant of
the interest in the Lease and/or the Premises that Tenant proposes to assign or
sublease as provided in the foregoing clauses (A) and (B), respectively, then
Landlord shall have the additional right to negotiate directly with Tenant's
proposed assignee or subtenant and to enter into a direct lease or occupancy
agreement with such party on such terms as shall be acceptable to Landlord in
its sole and absolute discretion, and Tenant hereby waives any claims against
Landlord related thereto, including, without limitation, any claims for any
compensation or profit related to such lease or occupancy agreement.

        (b) Without otherwise limiting the criteria upon which Landlord may
withhold its consent, Landlord shall be entitled to consider all reasonable
criteria including, but not limited to, the following: (i) whether or not the
proposed subtenant or assignee is engaged in a business which, and the use of
the Premises will be in a manner which, is in keeping with the then character
and nature of all other tenancies in the Project, (ii) whether the use to be
made of the Premises by the proposed subtenant or assignee will conflict with
any so-called "exclusive" use then in favor of any other tenant of the Building
or the Project, and whether such use would be prohibited by any other portion of
this Lease, including, but not limited to, any rules and regulations then in
effect, or under applicable Laws, and whether such use imposes an unreasonable
load upon the Premises and the Building and Project services, (iii) the business
reputation of the proposed individuals who will be managing and operating the
business operations of the assignee or subtenant, and the long-term financial
and competitive business prospects of the proposed assignee or subtenant, and
(iv) the creditworthiness and financial stability of the proposed assignee or
subtenant in light of the responsibilities involved. In any event, Landlord may
withhold its consent to any assignment or sublease if the actual use proposed to
be conducted in the Premises or portion thereof conflicts with the provisions of
Paragraph 9(a) or (b) above or with any other lease which restricts the use to
which any space in the Building or the Project may be put. Notwithstanding the
foregoing, Tenant may, without Landlord's consent, but upon notice and delivery
of evidence documenting such assignment or subletting, assign or sublet to an


                                       27


<PAGE>
Affiliate (as defined below) of the original Tenant, provided that such
Affiliate has a net worth (calculated in accordance with generally accepted
accounting principles, consistently applied) equal to or greater than the net
worth of the original Tenant on the Commencement Date or the date of the
proposed assignment or subletting, whichever is higher (such assignment or
subletting being referred to as a "PERMITTED TRANSFER"). For purposes hereof,
"AFFILIATE" shall mean any person, firm or corporation (A) which shall be
controlled by, under the control of, or under common control with the original
Tenant, (B) which results from a merger of, reorganization of, or consolidation
with the original Tenant or (C) which acquires substantially all of the stock or
assets of the original Tenant. For purposes hereof, "CONTROL" shall mean the
possession, direct or indirect, of the power to direct or cause the direction of
the management and policies of a person, firm or corporation, whether through
the ownership of voting securities, by contract or otherwise.

        (c) If Landlord approves an assignment or subletting as herein provided,
Tenant shall pay to Landlord, as Additional Rent, all of the difference, if any,
between (i) the Base Rent plus Additional Rent allocable to that part of the
Premises affected by such assignment or sublease pursuant to the provisions of
this Lease, and (ii) the rent and any additional rent payable by the assignee or
sublessee to Tenant, less actual leasing commissions, reasonable attorneys'
fees, tenant improvement costs and other reasonable out-of-pocket expenses, if
any, incurred by Tenant in connection with such assignment or sublease as
evidenced by written records reasonably satisfactory to Landlord. The assignment
or sublease agreement, as the case may be, after approval by Landlord, shall not
be amended without Landlord's prior written consent, which consent shall not be
unreasonably withheld, conditioned or delayed, and shall contain a provision
directing the assignee or subtenant to pay the rent and other sums due
thereunder directly to Landlord upon receiving written notice from Landlord that
Tenant is in default under this Lease with respect to the payment of Rent. In
the event that, notwithstanding the giving of such notice, Tenant collects any
rent or other sums from the assignee or subtenant, then Tenant shall hold such
sums in trust for the benefit of Landlord and shall immediately forward the same
to Landlord. Landlord's collection of such rent and other sums shall not
constitute an acceptance by Landlord of attornment by such assignee or
subtenant. A consent to one assignment, subletting, occupation or use shall not
be deemed to be a consent to any other or subsequent assignment, subletting,
occupation or use, and consent to any assignment or subletting shall in no way
relieve Tenant of any liability under this Lease. Any assignment or subletting
without Landlord's consent shall be void, and shall, at the option of Landlord,
constitute a Default under this Lease.

        (d) Notwithstanding any assignment or subletting, Tenant and any
guarantor or surety of Tenant's obligations under this Lease shall at all times
remain fully responsible and liable for the payment of the Rent and for
compliance with all of Tenant's other obligations under this Lease (regardless
of whether Landlord's approval has been obtained for any such assignment or
subletting).

        (e) Tenant shall pay Landlord's reasonable fees (including, without
limitation, the fees of Landlord's counsel), incurred in connection with
Landlord's review and processing of documents regarding any proposed assignment
or sublease, which fees shall not exceed $1,500.00.


                                       28


<PAGE>
        (f) Notwithstanding anything in this Lease to the contrary, in the event
Landlord consents to an assignment or subletting by Tenant in accordance with
the terms of this Paragraph 23, Tenant's assignee or subtenant shall have no
right to further assign this Lease or any interest therein or thereunder or to
further sublease all or any portion of the Premises except in accordance with
the terms of this Paragraph 23.

        (g) Tenant acknowledges and agrees that the restrictions, conditions and
limitations imposed by this Paragraph 23 on Tenant's ability to assign or
transfer this Lease or any interest herein, to sublet the Premises or any part
thereof, to transfer or assign any right or privilege appurtenant to the
Premises, or to allow any other person to occupy or use the Premises or any
portion thereof, are, for the purposes of California Civil Code Section 1951.4,
as amended from time to time, and for all other purposes, reasonable at the time
that the Lease was entered into, and shall be deemed to be reasonable at the
time that Tenant seeks to assign or transfer this Lease or any interest herein,
to sublet the Premises or any part thereof, to transfer or assign any right or
privilege appurtenant to the Premises, or to allow any other person to occupy or
use the Premises or any portion thereof.

24. TENANT'S DEFAULT

        The occurrence of any one of the following events shall constitute an
event of default on the part of Tenant ("DEFAULT"):

        (a) The vacation of the Premises for a period, in the aggregate, of six
(6) months or abandonment of the Premises by Tenant for a period of ten (10)
consecutive days or any vacation or abandonment of the Premises by Tenant which
would cause any insurance policy to be invalidated or otherwise lapse, or the
failure of Tenant to continuously operate Tenant's business in the Premises, in
each of the foregoing cases irrespective of whether or not Tenant is then in
monetary default under this Lease. Tenant agrees to notice and service of notice
as provided for in this Lease and waives any right to any other or further
notice or service of notice which Tenant may have under any statute or law now
or hereafter in effect;

        (b) Failure to pay any installment of Rent or any other monies due and
payable hereunder, said failure continuing for a period of three (3) days after
Landlord's notice of such failure;

        (c) A general assignment by Tenant or any guarantor or surety of
Tenant's obligations hereunder (collectively, "GUARANTOR") for the benefit of
creditors;

        (d) The filing of a voluntary petition in bankruptcy by Tenant or any
Guarantor, the filing by Tenant or any Guarantor of a voluntary petition for an
arrangement, the filing by or against Tenant or any Guarantor of a petition,
voluntary or involuntary, for reorganization, or the filing of an involuntary
petition by the creditors of Tenant or any Guarantor, said involuntary petition
remaining undischarged for a period of sixty (60) days;

        (e) Receivership, attachment, or other judicial seizure of substantially
all of Tenant's assets on the Premises, such attachment or other seizure
remaining undismissed or undischarged for a period of sixty (60) days after the
levy thereof;


                                       29


<PAGE>
        (f) Death or disability of Tenant or any Guarantor, if Tenant or such
Guarantor is a natural person, or the failure by Tenant or any Guarantor to
maintain its legal existence, if Tenant or such Guarantor is a corporation,
partnership, limited liability company, trust or other legal entity;

        (g) Failure of Tenant to execute and deliver to Landlord any estoppel
certificate, subordination agreement, or lease amendment in the time periods and
manner required by Paragraphs 30 or 31 or 42;

        (h) An assignment or sublease, or attempted assignment or sublease, of
this Lease or the Premises by Tenant contrary to the provision of Paragraph 23,
unless such assignment or sublease is expressly conditioned upon Tenant having
received Landlord's consent thereto;

        (i) Failure of Tenant to restore the Letter of Credit or the Security
Deposit to the amount and within the time period provided in Paragraph 4(a)(ii)
or Paragraph 7 above, respectively;

        (j) Failure in the performance of any of Tenant's covenants, agreements
or obligations hereunder (except those failures specified as events of Default
in subparagraph (b) above or subparagraphs (l) or (m) below or any other
subparagraphs of this Paragraph 24, which shall be governed by such other
Paragraphs), which failure continues for ten (10) days after written notice
thereof from Landlord to Tenant, provided that, if Tenant has exercised
reasonable diligence to cure such failure and such failure cannot be cured
within such ten (10) day period despite reasonable diligence, Tenant shall not
be in default under this subparagraph so long as Tenant thereafter diligently
and continuously prosecutes the cure to completion and actually completes such
cure within a reasonable time after the giving of the aforesaid written notice;

        (k) Chronic delinquency by Tenant in the payment of Rent, or any other
periodic payments required to be paid by Tenant under this Lease. "CHRONIC
DELINQUENCY" shall mean failure by Tenant to pay Rent, or any other periodic
payments required to be paid by Tenant under this Lease and Landlord's delivery
of written notice of such failure (i) for any three (3) months (consecutive or
nonconsecutive) during any period of twelve (12) months or (ii) for any six (6)
months (consecutive or nonconsecutive) during the Term. In the event of a
Chronic Delinquency, in addition to Landlord's other remedies for Default
provided in this Lease, at Landlord's option, Landlord shall have the right to
require that Rent be paid by Tenant quarterly, in advance;

        (1) Chronic overuse by Tenant or Tenant's Agents of the number of
undesignated parking spaces set forth in the Basic Lease Information. "CHRONIC
OVERUSE" shall mean use by Tenant or Tenant's Agents of a number of parking
spaces greater than the number of parking spaces set forth in the Basic Lease
Information more than three (3) times during any twelve (12) month period after
written notice by Landlord;

        (m) Any insurance required to be maintained by Tenant pursuant to this
Lease shall be canceled or terminated or shall expire or be reduced or
materially changed, except as permitted in this Lease; and

        (n) Any failure by Tenant to discharge any lien or encumbrance placed on
the Project or any part thereof in violation of this Lease within ten (10) days
after the date such lien or encumbrance is filed or recorded against the Project
or any part thereof.


                                       30


<PAGE>
        (o) Any Default (as defined in the 600/650 Gateway Lease) by Tenant (or
any assignee or sublessee of Tenant) under the terms of the 600/650 Gateway
Lease during any period in which Tenant (or any such assignee or sublessee) is
the tenant under the 600/650 Gateway Lease.

        Tenant agrees that any notice given by Landlord pursuant to Paragraph
24(j), (k) or (1) above shall satisfy the requirements for notice under
California Code of Civil Procedure Section 1161, and Landlord shall not be
required to give any additional notice in order to be entitled to commence an
unlawful detainer proceeding.

        Notwithstanding anything in this Paragraph 24 to the contrary, Tenant
may cure a Default under Paragraph 24(c), (d) or (f) above relating to the
Guarantor (or an event which with the giving of notice or the passing of time or
both, would constitute such a Default hereunder) ("POTENTIAL DEFAULT"), by
delivering to Landlord a Letter of Credit in accordance with Paragraph 4 of this
Lease within ten (10) days after written notice from Landlord of such Default or
Potential Default.

25. LANDLORD'S REMEDIES

        (a) TERMINATION. In the event of any Default by Tenant, then in addition
to any other remedies available to Landlord at law or in equity and under this
Lease, Landlord shall have the immediate option to terminate this Lease and all
rights of Tenant hereunder by giving written notice of such intention to
terminate. In the event that Landlord shall elect to so terminate this Lease
then Landlord may recover from Tenant:

               (i) the worth at the time of award of any unpaid Rent and any
other sums due and payable which have been earned at the time of such
termination; plus

               (ii) the worth at the time of award of the amount by which the
unpaid Rent and any other sums due and payable which would have been earned
after termination until the time of award exceeds the amount of such rental loss
Tenant proves could have been reasonably avoided; plus

               (iii) the worth at the time of award of the amount by which the
unpaid Rent and any other sums due and payable for the balance of the term of
this Lease after the time of award exceeds the amount of such rental loss that
Tenant proves could be reasonably avoided; plus

               (iv) any other amount necessary to compensate Landlord for all
the detriment proximately caused by Tenant's failure to perform its obligations
under this Lease or which in the ordinary course would be likely to result
therefrom, including, without limitation: (A) any costs or expenses incurred by
Landlord (1) in retaking possession of the Premises; (2) in maintaining,
repairing, preserving, restoring, replacing, cleaning, altering, remodeling or
rehabilitating the Premises or any affected portions of the Building or the
Project, including such actions undertaken in connection with the reletting or
attempted reletting of the Premises to a new tenant or tenants; (3) for leasing
commissions, advertising costs and other expenses of reletting the Premises; or
(4) in carrying the Premises, including taxes, insurance premiums, utilities and
security precautions; (B) any unearned brokerage commissions paid in connection
with this Lease; (C) reimbursement of any previously waived or abated Base Rent
or Additional Rent or any free rent or reduced rental rate granted hereunder;
and (D) any concession made or


                                       31


<PAGE>
paid by Landlord to the benefit of Tenant in consideration of this Lease
including, but not limited to, any moving allowances, contributions, payments or
loans by Landlord for tenant improvements or build-out allowances (including,
without limitation, any unamortized portion of the Tenant Improvement Allowance
(such Tenant Improvement Allowance to be amortized over the Term in the manner
reasonably determined by Landlord), or assumptions by Landlord of any of
Tenant's previous lease obligations; plus

               (v) such reasonable attorneys' fees incurred by Landlord as a
result of a Default, and costs in the event suit is filed by Landlord to enforce
such remedy; and plus

               (vi) at Landlord's election, such other amounts in addition to or
in lieu of the foregoing as may be permitted from time to time by applicable
law.

        As used in subparagraphs (i) and (ii) above, the "worth at the time of
award" is computed by allowing interest at an annual rate equal to twelve
percent (12%) per annum or the maximum rate permitted by law, whichever is less.
As used in subparagraph (iii) above, the "worth at the time of award" is
computed by discounting such amount at the discount rate of the Federal Reserve
Bank of San Francisco at the time of award, plus one percent (1%). Tenant waives
redemption or relief from forfeiture under California Code of Civil Procedure
Sections 1174 and 1179, or under any other pertinent present or future Law, in
the event Tenant is evicted or Landlord takes possession of the Premises by
reason of any Default of Tenant hereunder.

        (b) CONTINUATION OF LEASE. In the event of any Default by Tenant, then
in addition to any other remedies available to Landlord at law or in equity and
under this Lease, Landlord shall have the remedy described in California Civil
Code Section 1951.4 (Landlord may continue this Lease in effect after Tenant's
Default and abandonment and recover Rent as it becomes due, provided that Tenant
has the right to sublet or assign, subject only to reasonable limitations). In
addition, Landlord shall not be liable in any way whatsoever for its failure or
refusal to relet the Premises. For purposes of this Paragraph 25(b), the
following acts by Landlord will not constitute the termination of Tenant's right
to possession of the Premises:

               (i) Acts of maintenance or preservation or efforts to relet the
Premises, including, but not limited to, alterations, remodeling, redecorating,
repairs, replacements and/or painting as Landlord shall consider advisable for
the purpose of reletting the Premises or any part thereof; or

               (ii) The appointment of a receiver upon the initiative of
Landlord to protect Landlord's interest under this Lease or in the Premises.

        (c) RE-ENTRY. In the event of any Default by Tenant, Landlord shall also
have the right, with or without terminating this Lease, in compliance with
applicable law, to re-enter the Premises and remove all persons and property
from the Premises; such property may be removed and stored in a public warehouse
or elsewhere at the cost of and for the account of Tenant.

        (d) RELETTING. In the event of the abandonment of the Premises by Tenant
or in the event that Landlord shall elect to re-enter as provided in Paragraph
25(c) or shall take possession of the Premises pursuant to legal proceeding or
pursuant to any notice provided by law, then if Landlord does not elect to
terminate this Lease as provided in Paragraph 25(a), Landlord may from time to
time, without terminating this Lease, relet the Premises or any part thereof for
such


                                       32


<PAGE>
term or terms and at such rental or rentals and upon such other terms and
conditions as Landlord in its sole discretion may deem advisable with the right
to make alterations and repairs to the Premises in Landlord's sole discretion.
In the event that Landlord shall elect to so relet, then rentals received by
Landlord from such reletting shall be applied in the following order: (i) to
reasonable attorneys' fees incurred by Landlord as a result of a Default and
costs in the event suit is filed by Landlord to enforce such remedies; (ii) to
the payment of any indebtedness other than Rent due hereunder from Tenant to
Landlord; (iii) to the payment of any costs of such reletting; (iv) to the
payment of the costs of any alterations and repairs to the Premises; (v) to the
payment of Rent due and unpaid hereunder; and (vi) the residue, if any, shall be
held by Landlord and applied in payment of future Rent and other sums payable by
Tenant hereunder as the same may become due and payable hereunder. Should that
portion of such rentals received from such reletting during any month, which is
applied to the payment of Rent hereunder, be less than the Rent payable during
the month by Tenant hereunder, then Tenant shall pay such deficiency to
Landlord. Such deficiency shall be calculated and paid monthly. Tenant shall
also pay to Landlord, as soon as ascertained, any costs and expenses incurred by
Landlord in such reletting or in making such alterations and repairs not covered
by the rentals received from such reletting.

        (e) TERMINATION. No re-entry or taking of possession of the Premises by
Landlord pursuant to this Paragraph 25 shall be construed as an election to
terminate this Lease unless a written notice of such intention is given to
Tenant or unless the termination thereof is decreed by a court of competent
jurisdiction. Notwithstanding any reletting without termination by Landlord
because of any Default by Tenant, Landlord may at any time after such reletting
elect to terminate this Lease for any such Default.

        (f) CUMULATIVE REMEDIES. The remedies herein provided are not exclusive
and Landlord shall have any and all other remedies provided herein or by law or
in equity.

        (G) NO SURRENDER. No act or conduct of Landlord, whether consisting of
the acceptance of the keys to the Premises, or otherwise, shall be deemed to be
or constitute an acceptance of the surrender of the Premises by Tenant prior to
the expiration of the Term, and such acceptance by Landlord of surrender by
Tenant shall only flow from and must be evidenced by a written acknowledgment of
acceptance of surrender signed by Landlord. The surrender of this Lease by
Tenant, voluntarily or otherwise, shall not work a merger unless Landlord elects
in writing that such merger take place, but shall operate as an assignment to
Landlord of any and all existing subleases, or Landlord may, at its option,
elect in writing to treat such surrender as a merger terminating Tenant's estate
under this Lease, and thereupon Landlord may terminate any or all such subleases
by notifying the sublessee of its election so to do within five (5) days after
such surrender.

26. LANDLORD'S RIGHT TO PERFORM TENANT'S OBLIGATIONS

        (a) Without limiting the rights and remedies of Landlord contained in
Paragraph 25 above, if Tenant shall be in Default in the performance of any of
the terms, provisions, covenants or conditions to be performed or complied with
by Tenant pursuant to this Lease, then Landlord may at Landlord's option,
without any obligation to do so, and without notice to Tenant perform any such
term, provision, covenant, or condition, or make any such payment and Landlord
by reason of so doing shall not be liable or responsible for any loss or damage
thereby sustained by


                                       33


<PAGE>
Tenant or anyone holding under or through Tenant or any of Tenant's Agents,
unless caused by Landlord's gross negligence or willful misconduct.

        (b) Without limiting the rights of Landlord under Paragraph 26(a) above,
Landlord shall have the right at Landlord's option, without any obligation to do
so, to perform any of Tenant's covenants or obligations under this Lease without
notice to Tenant in the case of an emergency, as determined by Landlord in its
sole and absolute judgment, or if Landlord otherwise determines in its
reasonable discretion that such performance is necessary or desirable for the
proper management and operation of the Building or the Project or for the
preservation of the rights and interests or safety of other tenants of the
Building or the Project.

        (c) If Landlord performs any of Tenant's obligations hereunder in
accordance with this Paragraph 26, the full amount of the cost and expense
incurred or the payment so made or the amount of the loss so sustained shall
immediately be owing by Tenant to Landlord, and Tenant shall promptly pay to
Landlord upon demand, as Additional Rent, the full amount thereof with interest
thereon from the date of payment by Landlord at the lower of (i) ten percent
(10%) per annum, or (ii) the highest rate permitted by applicable law.

27. ATTORNEYS' FEES

        (a) If either party hereto fails to perform any of its obligations under
this Lease or if any dispute arises between the parties hereto concerning the
meaning or interpretation of any provision of this Lease, then the defaulting
party or the party not prevailing in such dispute, as the case may be, shall pay
any and all costs and expenses incurred by the other party on account of such
default and/or in enforcing or establishing its rights hereunder, including,
without limitation, court costs and reasonable attorneys' fees and
disbursements. Any such attorneys' fees and other expenses incurred by either
party in enforcing a judgment in its favor under this Lease shall be recoverable
separately from and in addition to any other amount included in such judgment,
and such attorneys' fees obligation is intended to be severable from the other
provisions of this Lease and to survive and not be merged into any such
judgment.

        (b) Without limiting the generality of Paragraph 27(a) above, if
Landlord utilizes the services of an attorney for the purpose of collecting any
Rent due and unpaid by Tenant or in connection with any other breach of this
Lease by Tenant, Tenant agrees to pay Landlord reasonable attorneys' fees as
determined by Landlord for such services, regardless of the fact that no legal
action may be commenced or filed by Landlord.

28. TAXES

        Tenant shall be liable for and shall pay, prior to delinquency, all
taxes levied against Tenant's Property. If any Alteration installed by Tenant
pursuant to Paragraph 12 or any of Tenant's Property is assessed and taxed with
the Project or Building, Tenant shall pay such taxes to Landlord within ten (10)
days after delivery to Tenant of a statement therefor.

29. EFFECT OF CONVEYANCE

        The term "LANDLORD" as used in this Lease means, from time to time, the
then current owner of the Building or the Project containing the Premises, so
that, in the event of any sale of the


                                       34


<PAGE>
Building or the Project, Landlord shall be and hereby is entirely freed and
relieved of all covenants and obligations of Landlord arising hereunder from and
after the date of such transfer, and it shall be deemed and construed, without
further agreement between the parties and the purchaser at any such sale, that
the purchaser of the Building or the Project has assumed and agreed to carry out
any and all covenants and obligations of Landlord hereunder.

30. TENANT'S ESTOPPEL CERTIFICATE

        From time to time, upon written request of either party (the "REQUESTING
PARTY"), the other party (the "RESPONDING PARTY") shall execute, acknowledge and
deliver to the Requesting Party or its designee, a written certificate stating:
(a) the date this Lease was executed, the Commencement Date of the Term and the
date the Term expires; (b) the date Tenant entered into occupancy of the
Premises; (c) the amount of Rent and the date to which such Rent has been paid;
(d) that this Lease is in full force and effect and has not been assigned,
modified, supplemented or amended in any way (or, if assigned, modified,
supplemented or amended, specifying the date and terms of any agreement so
affecting this Lease); (e) that this Lease represents the entire agreement
between the parties with respect to Tenant's right to use and occupy the
Premises (or specifying such other agreements, if any); (f) that all obligations
under this Lease to be performed by the Requesting Party as of the date of such
certificate have been satisfied (or specifying those as to which the Responding
Party claims that the Requesting Party has yet to perform); (g) that all
required contributions by Landlord to Tenant on account of Tenant's improvements
have been received (or stating exceptions thereto); (h) that on such date there
exist no defenses or offsets that Tenant has against the enforcement of this
Lease by Landlord (or stating exceptions thereto); (i) that no Rent or other sum
payable by Tenant hereunder has been paid more than one (1) month in advance (or
stating exceptions thereto); j) that a currently valid letter of credit and
security deposit have been deposited with Landlord, stating the original amount
thereof and any increases or decreases thereto; and (k) any other matters
evidencing the status of this Lease that may be required either by a lender
making a loan to Landlord to be secured by a deed of trust covering the Building
or the Project or by a purchaser of the Building or the Project or a purchase of
Tenant's stock or assets. Any such certificate delivered pursuant to this
Paragraph 30 may be relied upon by a prospective purchaser of Landlord's
interest or a mortgagee of Landlord's interest or assignee of any mortgage upon
Landlord's interest in the Premises. If the Responding Party shall fail to
provide such certificate within ten (10) days of receipt by the Responding Party
of a written request by the Requesting Party as herein provided, such failure
shall, at the Requesting Party's election, constitute a Default under this
Lease.

31. SUBORDINATION

        Landlord shall have the right to cause this Lease to be and remain
subject and subordinate to any and all mortgages, deeds of trust and ground
leases, if any ("ENCUMBRANCES") that are now or may hereafter be executed
covering the Premises, or any renewals, modifications, consolidations,
replacements or extensions thereof, for the full amount of all advances made or
to be made thereunder and without regard to the time or character of such
advances, together with interest thereon and subject to all the terms and
provisions thereof; provided only, and as an express condition precedent to
such subordination, that in the event of termination of any such ground lease or
upon the foreclosure of any such mortgage or deed of trust, so long as Tenant is
not in


                                       35

<PAGE>
default, the holder thereof ("HOLDER") shall agree to recognize Tenant's rights
under this Lease as long as Tenant shall pay the Rent and observe and perform
all the provisions of this Lease to be observed and performed by Tenant. Within
ten (10) days after Landlord's written request, Tenant shall execute,
acknowledge and deliver any and all reasonable documents required by Landlord or
the Holder to effectuate such subordination. If Tenant fails to do so, such
failure shall constitute a Default by Tenant under this Lease. Notwithstanding
anything to the contrary set forth in this Paragraph 31, Tenant hereby attorns
and agrees to attorn to any person or entity purchasing or otherwise acquiring
the Premises at any sale or other proceeding or pursuant to the exercise of any
other rights, powers or remedies under such Encumbrance.

32. ENVIRONMENTAL COVENANTS

        (a) Prior to executing this Lease, Tenant has completed, executed and
delivered to Landlord a Hazardous Materials Disclosure Certificate ("INITIAL
DISCLOSURE CERTIFICATE"), a fully completed copy of which is attached hereto as
EXHIBIT F and incorporated herein by this reference. Tenant covenants,
represents and warrants to Landlord that the information on the Initial
Disclosure Certificate is, to the best of Tenant's knowledge, true and correct
and accurately describes the Hazardous Materials which will be manufactured,
treated, used or stored on or about the Premises by Tenant or Tenant's Agents.
Tenant shall, on an annual basis, complete, execute and deliver to Landlord an
updated Disclosure Certificate (each, an "UPDATED DISCLOSURE CERTIFICATE")
describing Tenant's then current and proposed future uses of Hazardous Materials
on or about the Premises, which Updated Disclosure Certificates shall be in the
same format as that which is set forth in Exhibit F or in such updated format as
Landlord may reasonably require from time to time. Tenant shall deliver to
Landlord copies of any and all filings (a "FILING") made after the Commencement
Date with any state, local or federal governmental agencies relating to
Hazardous Materials used or to be used on or about the Premises and Tenant shall
promptly upon Landlord's request make appropriate representatives of Tenant
available to discuss with Landlord any such Filing. Tenant shall make no use of
Hazardous Materials on or about the Premises except as described in the Initial
Disclosure Certificate or an Updated Disclosure Certificate, as required
hereunder.

        (b) As used in this Lease, the term "HAZARDOUS MATERIALS" shall mean and
include any substance that is or contains (i) any "hazardous substance" as now
or hereafter defined in Section 101(14) of the Comprehensive Environmental
Response, Compensation, and Liability Act of 1980, as amended ("CERCLA") (42
U.S.C. Section 9601 et seq.) or any regulations promulgated under CERCLA; (ii)
any "hazardous waste" as now or hereafter defined in the Resource Conservation
and Recovery Act, as amended ("RCRA") (42 U.S.C. Section 6901 et seq.) or any
regulations promulgated under RCRA; (iii) any substance now or hereafter
regulated by the Toxic Substances Control Act, as amended ("TSCA") (15 U.S.C.
Section 2601 et seq.) or any regulations promulgated under TSCA; (iv) petroleum,
petroleum by-products, gasoline, diesel fuel, or other petroleum hydrocarbons;
(v) asbestos and asbestos-containing material, in any form, whether friable or
non-friable; (vi) polychlorinated biphenyls; (vii) lead and lead-containing
materials; or (viii) any additional substance, material or waste (A) the
presence of which on or about the Premises (1) requires reporting, investigation
or remediation under any Environmental Laws (as hereinafter defined), (2) causes
or threatens to cause a nuisance on the Premises or any adjacent area or
property or poses or threatens to pose a hazard to the health or safety of
persons on the Premises or any adjacent area or property, or (3) which, if it
emanated or migrated from the



                                       36
<PAGE>

Premises, could constitute a trespass, or (B) which is now or is hereafter
classified or considered to be hazardous or toxic under any Environmental Laws.

        (c) As used in this Lease, the term "ENVIRONMENTAL LAWS" shall mean and
include (i) CERCLA, RCRA and TSCA; and (ii) any other federal, state or local
laws, ordinances, statutes, codes, rules, regulations, orders or decrees now or
hereinafter in effect relating to (A) pollution, (B) the protection or
regulation of human health, natural resources or the environment, (C) the
treatment, storage or disposal of Hazardous Materials, or (D) the emission,
discharge, release or threatened release of Hazardous Materials into the
environment.

        (d) Tenant agrees that during its use and occupancy of the Premises it
will (i) not (A) permit Hazardous Materials to be present on or about the
Premises except in a manner and quantity necessary for the ordinary performance
of Tenant's business or (B) release, discharge or dispose of any Hazardous
Materials on, in, at, under, or emanating from, the Premises, the Building or
the Project; (ii) comply with all Environmental Laws relating to Tenant's use of
Hazardous Materials in, on or about the Premises and not engage in or permit
Tenant's Agents to engage in any activity in, on or about the Premises in
violation of any Environmental Laws; and (iii) immediately notify Landlord of
(A) any inquiry, test, investigation or enforcement proceeding by any
governmental agency or authority against Tenant, Landlord or the Premises,
Building or Project relating to any Hazardous Materials or under any
Environmental Laws or (B) the occurrence of any event or existence of any
condition that would cause a breach of any of the covenants set forth in this
Paragraph 32.

        (e) If Tenant's use of Hazardous Materials on or about the Premises
results in a release, discharge or disposal of Hazardous Materials on, in, at,
under, or emanating from, the Premises, the Building or the Project, Tenant
agrees to investigate, clean up, remove or remediate such Hazardous Materials in
full compliance with (i) the requirements of (A) all Environmental Laws and (B)
any governmental agency or authority responsible for the enforcement of any
Environmental Laws; and (ii) any additional requirements of Landlord that are
reasonably necessary to protect the value of the Premises, the Building or the
Project.

        (f) Upon reasonable notice to Tenant, Landlord may inspect the Premises
and surrounding areas for the purpose of determining whether there exists on or
about the Premises any Hazardous Material or other condition or activity that is
in violation of the requirements of this Lease or of any Environmental Laws.
Such inspections may include, but are not limited to, entering upon the property
adjacent to or surrounding the Premises with drill rigs or other machinery for
the purpose of obtaining laboratory samples. Landlord shall not be limited in
the number of such inspections during the Term of this Lease but such
inspections shall be reasonable in light of the circumstances. In the event (i)
such inspections reveal the presence of any such Hazardous Material or other
condition or activity caused by Tenant or its Agents in violation of the
requirements of this Lease or of any Environmental Laws, or (ii) Tenant or its
Agents contribute or knowingly consent to the importation of any Hazardous
Materials in, on, under, through or about the Premises, the Building or the
Project or knowingly exacerbate the condition of or the conditions caused by any
Hazardous Materials in, on, under, through or about the Premises, the Building
or the Project, Tenant shall reimburse Landlord for the cost of such inspections
within ten (10) days of receipt of a written statement therefor. Tenant will
supply to Landlord such historical and operational information regarding the
Premises and surrounding



                                       37
<PAGE>

areas as may be reasonably requested to facilitate any such inspection and will
make available for meetings appropriate personnel having knowledge of such
matters. Tenant agrees to give Landlord at least sixty (60) days' prior notice
of its intention to vacate the Premises so that Landlord will have an
opportunity to perform such an inspection prior to such vacation. The right
granted to Landlord herein to perform inspections shall not create a duty on
Landlord's part to inspect the Premises, or liability on the part of Landlord
for Tenant's use, storage, treatment or disposal of Hazardous Materials, it
being understood that Tenant shall be solely responsible for all liability in
connection therewith.

        (g) Landlord shall have the right, but not the obligation, prior or
subsequent to a Default, without in any way limiting Landlord's other rights and
remedies under this Lease, to enter upon the Premises, or to take such other
actions as it deems necessary or advisable, to investigate, clean up, remove or
remediate any Hazardous Materials or contamination by Hazardous Materials
present on, in, at, under, or emanating from, the Premises, the Building or the
Project in violation of Tenant's obligations under this Lease or under any
Environmental Laws. Notwithstanding any other provision of this Lease, Landlord
shall also have the right, at its election, in its own name or as Tenant's
agent, to negotiate, defend, approve and appeal, at Tenant's expense, any action
taken or order issued by any governmental agency or authority with regard to any
such Hazardous Materials or contamination by Hazardous Materials. All costs and
expenses paid or incurred by Landlord in the exercise of the rights set forth in
this Paragraph 32 shall be payable by Tenant upon demand.

        (h) Tenant shall surrender the Premises to Landlord upon the expiration
or earlier termination of this Lease free of debris, waste or Hazardous
Materials placed on, about or near the Premises by Tenant or Tenant's Agents,
and in a condition which complies with (i) all Environmental Laws relating to
Hazardous Materials placed on, about or near the Premises by Tenant or Tenant's
Agents and (ii) any additional requirements of landlord that are reasonably
necessary to protect the value of the Premises, the Building or the Project,
including, without limitation, the obtaining of any closure permits or other
governmental permits or approvals related to Tenant's use of Hazardous Materials
in or about the Premises. Tenant's obligations and liabilities pursuant to the
provisions of this Paragraph 32 shall survive the expiration or earlier
termination of this Lease. If it is determined by Landlord that the condition of
all or any portion of the Premises, the Building, and/or the Project is not in
compliance with the provisions of this Lease with respect to Hazardous
Materials, including, without limitation, all Environmental Laws, at the
expiration or earlier termination of this Lease, then at Landlord's sole option,
Landlord may require Tenant to hold over possession of the Premises until Tenant
can surrender the Premises to Landlord in the condition in which the Premises
existed as of the Commencement Date and prior to the appearance of such
Hazardous Materials which Tenant or Tenant's Agents caused to be present except
for normal wear and tear, including, without limitation, the conduct or
performance of any closures as required by any Environmental Laws. The burden of
proof hereunder shall be upon Tenant. For purposes hereof, the term "NORMAL WEAR
AND TEAR" shall not include any deterioration in the condition or diminution of
the value of any portion of the Premises, the Building, and/or the Project in
any manner whatsoever related to directly, or indirectly, Hazardous Materials.
Any such holdover by Tenant will be with Landlord's consent, will not be
terminable by Tenant in any event or circumstance and will otherwise be subject
to the provisions of Paragraph 35 of this Lease.



                                       38
<PAGE>

        (i) Tenant agrees to indemnify and hold harmless Landlord from and
against any and all claims, losses (including, without limitation, loss in value
of the Premises, the Building or the Project, liabilities and expenses
(including attorneys' fees)) sustained by Landlord attributable to (i) any
Hazardous Materials placed on or about the Premises, the Building or the Project
by Tenant or Tenant's Agents, or (ii) Tenant's breach of any provision of this
Paragraph 32.

        (j) Landlord agrees to indemnify and hold harmless Tenant from and
against any and all claims, losses (including, without limitation, liabilities
and expenses (including attorneys' fees)) actually sustained by Tenant
attributable to any Hazardous Materials placed on or about the Premises, the
Building or the Project by Landlord or Landlord's Agents, but specifically
excluding any other third parties.

        (k) The provisions of this Paragraph 32 shall survive the expiration or
earlier termination of this Lease.

33. NOTICES

        All notices and demands which are required or may be permitted to be
given to either party by the other hereunder shall be in writing and shall be
sent by United States mail, postage prepaid, certified, or by personal delivery
or overnight courier, addressed to the addressee at Tenant's Address or
Landlord's Address as specified in the Basic Lease Information, or to such other
place as either party may from time to time designate in a notice to the other
party given as provided herein. Copies of all notices and demands given to
Landlord shall additionally be sent to Landlord's property manager at the
address specified in the Basic Lease Information or at such other address as
Landlord may specify in writing from time to time. Notice shall be deemed given
upon actual receipt (or attempted delivery if delivery is refused ), if
personally delivered, or one (1) business day following deposit with a reputable
overnight courier that provides a receipt, or on the third (3rd) day following
deposit in the United States mail in the manner described above.

34. WAIVER

        The waiver of any breach of any term, covenant or condition of this
Lease shall not be deemed to be a waiver of such term, covenant or condition or
of any subsequent breach of the same or any other term, covenant or condition
herein contained. The subsequent acceptance of Rent by Landlord shall not be
deemed to be a waiver of any preceding breach by Tenant, other than the failure
of Tenant to pay the particular rental so accepted, regardless of Landlord's
knowledge of such preceding breach at the time of acceptance of such Rent. No
delay or omission in the exercise of any right or remedy of Landlord in regard
to any Default by Tenant shall impair such a right or remedy or be construed as
a waiver. Any waiver by Landlord of any Default must be in writing and shall not
be a waiver of any other Default concerning the same or any other provisions of
this Lease.

35. HOLDING OVER

        Any holding over after the expiration of the Term, without the express
written consent of Landlord, shall constitute a Default and, without limiting
Landlord's remedies provided in this Lease, such holding over shall be construed
to be a tenancy at sufferance, at a rental rate of one



                                       39
<PAGE>

hundred fifty percent (150%) of the Base Rent last due in this Lease, plus
Additional Rent, and shall otherwise be on the terms and conditions herein
specified, so far as applicable; provided, however, that in no event shall any
renewal or expansion option or other similar right or option contained in this
Lease be deemed applicable to any such tenancy at sufferance. If the Premises
are not surrendered at the end of the Term or sooner termination of this Lease,
and in accordance with the provisions of Paragraphs 11 and 32(h), Tenant shall
indemnify, defend and hold Landlord harmless from and against any and all loss
or liability resulting from delay by Tenant in so surrendering the Premises
including, without limitation, any loss or liability resulting from any claim
against Landlord made by any succeeding tenant or prospective tenant caused by
such delay and losses to Landlord due to lost opportunities to lease any portion
of the Premises to any such succeeding tenant or prospective tenant, together
with, in each case, actual attorneys' fees and costs.

36. SUCCESSORS AND ASSIGNS

        (a) The terms, covenants and conditions of this Lease shall, subject to
the provisions as to assignment, apply to and bind the heirs, successors,
executors, administrators and assigns of all of the parties hereto. If Tenant
shall consist of more than one entity or person, the obligations of Tenant under
this Lease shall be joint and several.

        (b) Notwithstanding anything in this Lease to the contrary, Landlord
shall have the right to sell, transfer, encumber or otherwise convey or
hypothecate all or any part of its interest in the Building, and all of
Landlord's related rights hereunder, to any Person, provided that the original
Landlord hereunder retains, or a Reasonably Qualified Substitute Developer (as
hereinafter defined) has, the obligation to construct and deliver the Building
in accordance with the terms hereof. As used herein, "REASONABLY QUALIFIED
SUBSTITUTE DEVELOPER" shall include (i) a developer that at the time of any such
conveyance, owns, manages or has developed one or more commercial properties
containing, in the aggregate, at least one hundred thousand (100,000) square
feet of space for biotechnology research and development use, or (ii) a
developer that at the time of any such conveyance has one or more principals
who, in the aggregate, have experience in developing at least seventy five
thousand (75,000) square feet of space for biotechnology research and
development use. Tenant agrees to cooperate with Landlord at Landlord's request
and at Landlord's sole cost and expense (except as limited below) and to enter
into such substitute or replacement lease documents (the "SUBSTITUTE LEASE
DOCUMENTS") as Landlord shall reasonably request to effectuate the intent of
this subparagraph 36(b); provided, however, that the obligations of Tenant under
this Lease shall not be increased nor shall Tenant's rights under this Lease be
diminished as a result of the execution and delivery of such Substitute Lease
Documents; and provided, further, that Landlord shall pay Tenant's reasonable
legal fees incurred in connection with such Substitute Lease Documents.

37. TIME

        Time is of the essence of this Lease and each and every term, condition
and provision herein.



                                       40
<PAGE>

38. BROKERS

        Landlord and Tenant each represents and warrants to the other that
neither it nor its officers or agents nor anyone acting on its behalf has dealt
with any real estate broker in the negotiating or making of this Lease, and each
party agrees to indemnify and hold harmless the other from any claim or claims,
and costs and expenses, including attorneys' fees, incurred by the indemnified
party in conjunction with any such claim or claims of any broker or brokers to a
commission in connection with this Lease as a result of the actions of the
indemnifying party.

39. LIMITATION OF LIABILITY

        Tenant agrees that, in the event of any default or breach by Landlord
with respect to any of the terms of the Lease to be observed and performed by
Landlord or with respect to the enforcement of an indemnity obligation of
Landlord under this Lease (a) Tenant shall look solely to the then-current
landlord's interest in the Building for the satisfaction of such indemnity
obligation of Landlord or for satisfaction of Tenant's remedies for the
collection of a judgment (or other judicial process) requiring the payment of
money by Landlord; (b) no other property or assets of Landlord, its partners,
shareholders, officers, directors, employees, investment advisors, or any
successor in interest of any of them (collectively, the "LANDLORD PARTIES")
shall be subject to levy, execution or other enforcement procedure for the
satisfaction of Tenant's remedies; (c) no personal liability shall at any time
be asserted or enforceable against the Landlord Parties; and (d) no judgment
will be taken against the Landlord Parties (except for a judgment against
Landlord which is enforceable only to the extent of Landlord's interest in the
Building). The provisions of this Paragraph shall apply only to the Landlord and
the parties herein described, and shall not be for the benefit of any insurer
nor any other third party.

40. FINANCIAL STATEMENTS

        Within ten (10) days after Landlord's request, Tenant shall deliver to
Landlord the then current financial statements of Tenant (including interim
periods following the end of the last fiscal year for which annual statements
are available), prepared or compiled by a certified public accountant, including
a balance sheet and profit and loss statement for the most recent prior year,
all prepared in accordance with generally accepted accounting principles
consistently applied.

41. RULES AND REGULATIONS

        Tenant agrees to comply with such reasonable rules and regulations as
Landlord may adopt from time to time for the orderly and proper operation of the
Building and the Project. Such rules may include but shall not be limited to the
following: (a) restriction of employee parking to a limited, designated area or
areas; and (b) regulation of the removal, storage and disposal of Tenant's
refuse and other rubbish at the sole cost and expense of Tenant. The then
current rules and regulations shall be binding upon Tenant upon delivery of a
copy of them to Tenant. Landlord shall not be responsible to Tenant for the
failure of any other person to observe and abide by any of said rules and
regulations; provided, however, that Landlord shall enforce such rules and
regulation in a non-discriminatory manner. Landlord's current rules and
regulations are attached to this Lease as EXHIBIT E.



                                       41
<PAGE>

42. MORTGAGEE PROTECTION

        (a) MODIFICATIONS FOR LENDER. If, in connection with obtaining financing
for the Project or any portion thereof, Landlord's lender shall request
reasonable modifications to this Lease as a condition to such financing, Tenant
shall not unreasonably withhold, delay or defer its consent to such
modifications, provided that such modifications do not materially adversely
affect Tenant's rights or increase Tenant's obligations under this Lease.

        (b) RIGHTS TO CURE. Tenant agrees to give to any trust deed or mortgage
holder ("HOLDER"), by registered mail, at the same time as it is given to
Landlord, a copy of any notice of default given to Landlord, provided that prior
to such notice Tenant has been notified, in writing (by way of notice of
assignment of rents and leases, or otherwise) of the address of such Holder.
Tenant further agrees that if Landlord shall have failed to cure such default
within the time provided for in this Lease, then the Holder shall have an
additional twenty (20) days after expiration of such period, or after receipt of
such notice from Tenant (if such notice to the Holder is required by this
Paragraph 42(b)), whichever shall last occur within which to cure such default
or if such default cannot be cured within that time, then such additional time
as may be necessary if within such twenty (20) days, any Holder has commenced
and is diligently pursuing the remedies necessary to cure such default
(including, but not limited to, commencement of foreclosure proceedings, if
necessary to effect such cure), in which event this Lease shall not be
terminated.

43. ENTIRE AGREEMENT

        This Lease, including the Exhibits and any Addenda attached hereto,
which are hereby incorporated herein by this reference, contains the entire
agreement of the parties hereto, and no representations, inducements, promises
or agreements, oral or otherwise, between the parties, not embodied herein or
therein, shall be of any force and effect.

44. INTEREST

        Any installment of Rent and any other sum due from Tenant under this
Lease which is not received by Landlord when due shall bear interest from the
date such payment was originally due under this Lease until paid at an annual
rate equal to the maximum rate of interest permitted by law; provided,
however, that Landlord hereby waives its right to collect interest on the first
two (2) such sums not paid to Landlord as required hereunder. Payment of such
interest shall not excuse or cure any Default by Tenant. In addition, Tenant
shall pay all costs and reasonable attorneys' fees incurred by Landlord in
collection of such amounts.

45. INTERPRETATION

        This Lease shall be construed and interpreted in accordance with the
laws of the State of California. The parties acknowledge and agree that no rule
of construction to the effect that any ambiguities are to be resolved against
the drafting party shall be employed in the interpretation of this Lease,
including the Exhibits and any Addenda attached hereto. All captions in this
Lease are for reference only and shall not be used in the interpretation of this
Lease. Whenever required by the context of this Lease, the singular shall
include the plural, the masculine shall include the feminine, and vice versa. If
any provision of this Lease shall be determined to be illegal or unenforceable,
such determination shall not affect any other provision of this Lease and



                                       42
<PAGE>

all such other provisions shall remain in full force and effect. As used herein,
the term "gross negligence" shall mean any action or inaction taken with a
reckless disregard for the consequences. Unless otherwise specifically stated
herein to the contrary, Landlord's consent may be given or withheld in
Landlord's sole and absolute discretion.

46. REPRESENTATIONS AND WARRANTIES

        (a) OF TENANT. Tenant hereby makes the following representations and
warranties, each of which is material and being relied upon by Landlord, is true
in all respects as of the date of this Lease, and shall survive the expiration
or termination of the Lease.

                (i) If Tenant is an entity, Tenant is duly organized, validly
existing and in good standing under the laws of the state of its organization
and the persons executing this Lease on behalf of Tenant have the full right and
authority to execute this Lease on behalf of Tenant and to bind Tenant without
the consent or approval of any other person or entity. Tenant has full power,
capacity, authority and legal right to execute and deliver this Lease and to
perform all of its obligations hereunder. This Lease is a legal, valid and
binding obligation of Tenant, enforceable in accordance with its terms.

                (ii) Tenant has not (A) made a general assignment for the
benefit of creditors, (B) filed any voluntary petition in bankruptcy or suffered
the filing of an involuntary petition by any creditors, (C) suffered the
appointment of a receiver to take possession of all or substantially all of its
assets, (D) suffered the attachment or other judicial seizure of all or
substantially all of its assets, (E) admitted in writing its inability to pay
its debts as they come due, or (F) made an offer of settlement, extension or
composition to its creditors generally.

        (b) OF LANDLORD. Landlord hereby makes the following representations and
warranties, each of which is material and being relied upon by Tenant, is true
in all respects as of the date of this Lease, and shall survive the expiration
or termination of the Lease.

                (i) If Landlord is an entity, Landlord is duly organized,
validly existing and in good standing under the laws of the state of its
organization and the persons executing this Lease on behalf of Landlord have the
full right and authority to execute this Lease on behalf of Landlord and to bind
Landlord without the consent or approval of any other person or entity. Landlord
has full power, capacity, authority and legal right to execute and deliver this
Lease and to perform all of its obligations hereunder. This Lease is a legal,
valid and binding obligation of Landlord, enforceable in accordance with its
terms.

                (ii) Landlord has not (A) made a general assignment for the
benefit of creditors, (B) filed any voluntary petition in bankruptcy or suffered
the filing of an involuntary petition by any creditors, (C) suffered the
appointment of a receiver to take possession of all or substantially all of its
assets, (D) suffered the attachment or other judicial seizure of all or
substantially all of its assets, (E) admitted in writing its inability to pay
its debts as they come due, or (F) made an offer of settlement, extension or
composition to its creditors generally.



                                       43
<PAGE>

47. SECURITY

        (a) Tenant acknowledges and agrees that, while Landlord may engage
security personnel to patrol the Building or the Project, Landlord is not
providing any security services with respect to the Premises, the Building or
the Project and that Landlord shall not be liable to Tenant for, and Tenant
waives any claim against Landlord with respect to, any loss by theft or any
other damage suffered or incurred by Tenant in connection with any unauthorized
entry into the Premises or any other breach of security with respect to the
Premises, the Building or the Project.

        (b) Tenant hereby agrees to the exercise by Landlord and Landlord's
Agents, within their sole discretion, of such security measures as, but not
limited to, the evacuation of the Premises, the Building or the Project for
cause, suspected cause or for drill purposes, the denial of any access to the
Premises, the Building or the Project and other similarly related actions that
it deems necessary to prevent any threat of property damage or bodily injury.
The exercise of such security measures by Landlord and Landlord's Agents, and
the resulting interruption of service and cessation of Tenant's business, if
any, shall not be deemed an eviction or disturbance of Tenant's use and
possession of the Premises, or any part thereof, or render Landlord or
Landlord's Agents liable to Tenant for any resulting damages, unless caused by
the gross negligence or willful misconduct of Landlord, or relieve Tenant from
Tenant's obligations under this Lease.

48. JURY TRIAL WAIVER

        Tenant hereby waives any right to trial by jury with respect to any
action or proceeding (a) brought by Landlord, Tenant or any other party,
relating to (i) this Lease and/or any understandings or prior dealings between
the parties hereto, or (ii) the Premises, the Building or the Project or any
part thereof, or (b) to which Landlord is a party. Tenant hereby agrees that
this Lease constitutes a written consent to waiver of trial by jury pursuant to
the provisions of California Code of Civil Procedure Section 631.

49. OPTION TO RENEW

        Tenant shall have two (2) options (each a "RENEWAL OPTION") to extend
the Term of this Lease, each for a five (5) year extended term (the "RENEWAL
TERM"); provided, however, that as a condition to exercising such Renewal
Option, Tenant must be in possession of at least fifty percent (50%) of the
square footage of the Building. Each Renewal Option shall be effective only if
Tenant is not in Default under this Lease, nor has any event occurred which with
the giving of notice or the passage of time, or both, would constitute a Default
hereunder, either at the time of exercise of the Renewal Option or the time of
commencement of the Renewal Term. If Tenant exercises the first Renewal Option
in accordance herewith, the first Renewal Term shall commence on the day
following the last day of the initial Term and end on the day preceding the
fifth anniversary thereof. If Tenant exercises the second Renewal Option, the
second Renewal Term shall commence on the day following the last day of the
first Renewal Term and end on the day preceding the fifth anniversary thereof.
The second Renewal Option may not be exercised unless Tenant has previously
exercised the first Renewal Option. Each Renewal Term, if properly exercised,
shall be upon the same terms and conditions as the Lease except for Base Rent
(which shall be determined as provided in the following provisions of this



                                       44
<PAGE>

Paragraph). The Renewal Option shall be personal to Tenant and any transferee of
a Permitted Transfer and shall not be assignable or otherwise transferable to
any other permitted assignee, subtenant or other third parties and there shall
be no further Renewal Option beyond the expiration of the second Renewal Term.
In order to exercise a Renewal Option, Tenant shall give written notice to
Landlord of Tenant's exercise of such election ("TENNANT'S NOTICE") at least ten
(10) months prior to expiration of the then current Term and if such notice is
not so given, the Renewal Option shall lapse; the Tenant hereby expressly
acknowledges and agrees that time is of the essence for purposes of notice of
exercise of a Renewal Option and that Tenant's failure to do so by said date
will relieve Landlord of any obligation under this Paragraph. If Tenant gives
such notice within the time prescribed, Landlord and Tenant shall be deemed to
have entered into an extension of this Lease with respect to the entirety of the
Premises for a five (5) year extended term on the terms and conditions set forth
herein.

        The monthly Base Rent payable during any Renewal Term shall be an amount
equal to the greater of (a) the monthly Base Rent payable for the last month of
the then expiring Term, or (b) the Fair Market Rent (as hereinafter defined),
multiplied by the number of square feet constituting the Premises. "FAIR MARKET
RENT" shall mean the rate being charged for comparable Office/R&D space in the
Northern Peninsula market area (excluding the City of San Francisco), taking
into consideration: tenant credit, tenant improvements or allowances provided or
to be provided and leasing commissions but excluding tenant improvements paid
for by Tenant. Landlord and Tenant shall meet and attempt in good faith to
mutually determine Fair Market Rent for the purposes of the foregoing. If the
parties have not reached agreement on Fair Market Rent by the date that is
thirty (30) days after Tenant's Notice, each party shall appoint an appraiser
and shall give to the other party the identity of the appraiser no later than
the date that is forty (40) days after the Tenant's Notice. If either party
fails to appoint an appraiser by the date that is forty (40) days after Tenant's
Notice, the sole appraiser appointed, if any, shall determine the Fair Market
Rent. If two appraisers are appointed, they shall immediately meet and attempt
to agree upon such Fair Market Rent. If the appraisers cannot reach agreement on
the Fair Market Rent by the date that is sixty (60) days after Tenant's Notice,
each appraiser shall submit a determination of Fair Market Rent to Landlord and
Tenant. If the determinations of Fair Market Rent made by these two appraisers
vary by five percent (5%) or less, the Fair Market Rent shall be the average of
the two determinations. If the determinations vary by more than five percent
(5%), the two appraisers shall within ten (10) days after submission of their .
determinations, appoint a third appraiser. If the two appraisers shall be unable
to agree on the selection of a third appraiser within the 10-day period, then
either Tenant or Landlord may request such appointment by petitioning the
presiding judge of the Superior Court in and for the County of San Mateo. Such
third appraiser shall, within thirty (30) days after appointment, make a
determination of the Fair Market Rent and submit such determination to Landlord
and Tenant. The Fair Market Rent shall be the determination of Fair Market Rent
submitted by the original two appraisers that is closer to the Fair Market Rent
determination of the third appraiser. If the third appraiser's determination is
exactly between the Fair Market Rent determination of the original two
appraisers, then Fair Market Rent shall be the average of the original two
determinations. For purposes of this Paragraph, "APPRAISER" shall mean a
licensed commercial real estate broker or MAI designated appraiser with not less
than 5 years of full-time commercial appraisal or brokerage experience in the
Northern Peninsula market area. Each party shall bear the fees and costs
incurred by each party's appraiser in connection with the determination of Fair
Market Rent and all fees and costs incurred by the third appraiser, if any, in
connection with the



                                       45
<PAGE>

determination of Fair Market Rent shall be shared equally by Landlord and
Tenant. If the determination of Fair Market Rent has not been made by the
expiration of the then expiring Term, Tenant shall (i) continue to pay monthly
Base Rent at the monthly Base Rent for the last month of the Term (the
"ARBITRATION PERIOD BASE RENT") as well as any Additional Rent due under the
Lease, and (ii) pay to Landlord, or receive as a refund from Landlord, as
applicable, on the first day of the month after the determination of Fair Market
Rent is made, an amount, if any, equal to the difference between the Arbitration
Period Base Rent that was paid to Landlord and the monthly Base Rent for the
Renewal Term that should have been paid to Landlord as the monthly Base Rent for
the Renewal Term as determined hereunder.

50. RIGHT OF FIRST OFFER

        (a) If subsequent to full execution of this Lease, Landlord desires to
sell the Building, Landlord shall notify Tenant in writing of such intent to
sell (the "OFFER NOTICE"); provided, however, that Landlord shall not be
required to provide Tenant with the Offer Notice if Landlord has previously
terminated this Lease with respect to, or recaptured, all or any portion of the
Premises. Tenant's right to receive the Offer Notice shall further be effective
only if Tenant is not in Default under this Lease, nor has any event occurred
which with the giving of notice or the passage of time, or both, would
constitute a Default hereunder. In the event Tenant desires to purchase the
Building, Tenant shall notify Landlord in writing of its election to purchase
the Building (the "Election Notice") within thirty (30) days following Tenant's
receipt of the Offer Notice. In the event Tenant timely delivers the Election
Notice to Landlord, the parties shall thereafter execute a purchase and sale
agreement (the "PURCHASE AND SALE AGREEMENT") reasonably acceptable to both
Landlord and Tenant with the purchase price of the Building (the "PURCHASE
PRICE") equal to the quotient of the Net Operating Income (as defined below) of
the Building divided by [*] and with a closing (the "CLOSING") to be held on or
before the date that is one hundred and eighty (180) days after delivery of the
Offer Notice. If Tenant fails to deliver an Election Notice within the 30-day
time period, or if Tenant has not executed the Purchase and Sale Agreement
within thirty (30) days after the date of Landlord's receipt of the Election
Notice, Tenant's right to purchase the Building hereunder shall automatically
terminate and be of no further force and effect with respect to Landlord or any
subsequent purchaser and Landlord shall thereafter have the right to sell the
Building at any time to any third party. Tenant hereby expressly acknowledges
and agrees that time is of the essence for purposes of the Election Notice and
that Tenant's failure to deliver such Election Notice as specified herein will
relieve Landlord of any obligation under this Paragraph.

        (b) As used herein, "NET OPERATING INCOME" shall mean the Base Rent due
under the Lease with respect to the Building for the twelve (12) full calendar
months following the Offer Notice; provided, however, that if Landlord delivers
an Offer Notice to Tenant at any time prior to the Commencement Date, then "Net
Operating Income" shall mean the Base Rent due under the Lease for the twelve
(12) full calendar months following the Commencement Date, and Tenant shall
receive a credit against the Purchase Price equal to the cost (calculated as of
the date of Closing) reasonably estimated by Landlord to complete the Base
Building Improvements (exclusive of any Tenant Requested Base Building
Improvements and any improvements or costs required to be paid by Tenant under
the terms of the Lease), assuming for purposes of this determination that the
Base Building Improvements for the Building shall be similar in design

--------------
* Confidential treatment requested.


                                       46
<PAGE>

and quality to the Base Building Improvements constructed by Landlord under the
600/650 Lease.

        (c) Notwithstanding anything in this Paragraph 50 to the contrary, this
Paragraph shall be inapplicable to, and Landlord shall have no obligation to
provide an Offer Notice to Tenant in connection with any sale or proposed sale
of the Building to any Person (as defined below) who is the owner of at least a
fifty-one percent (51%) legal or beneficial interest and holder of a controlling
interest in Landlord as of the date of this Lease or at anytime in the future.
As used herein "PERSON" shall mean any natural person, corporation, firm,
association or other entity, whether acting in an individual, fiduciary or other
capacity. Tenant's rights under this Paragraph 50 shall survive Landlord's
transfer to such Person.

51. INDEPENDENT OBLIGATIONS

        This Lease is separate from and independent of that certain Lease
Agreement executed by and between Landlord and Tenant, dated as of November 7,
1997, as amended by a First Amendment to Lease Agreement dated as of November
10, 1998, which lease covers certain improved real property consisting of two
office buildings commonly known as 600 and 650 Gateway Boulevard, South San
Francisco, California (as amended, the "600/650 GATEWAY LEASE"). Without
limiting the generality of the foregoing, subject only to Paragraph 24(o) above,
no termination of this Lease prior to the Expiration Date (including, without
limitation, any termination of this Lease by Tenant pursuant to any termination
option contained in EXHIBIT A or EXHIBIT B hereto) shall lead to or result in a
termination of the 600/650 Gateway Lease, which shall continue in full force and
effect for the full term thereof in accordance with the provisions contained
therein.

52. MEMORANDUM OF LEASE

        Promptly after full execution of this Lease, Landlord and Tenant shall
execute and cause to be recorded a Memorandum of Lease in the form attached
hereto as EXHIBIT I.

                            (SIGNATURES ON NEXT PAGE)



                                       47
<PAGE>

        Landlord and Tenant have executed and delivered this Lease as of the
Lease Date specified in the Basic Lease Information.

                    LANDLORD:  HMS GATEWAY OFFICE, L.P.,
                               a Delaware limited liability company

                               By: Hines Gateway Office, L.P.,
                                   General Partner

                                   By: Hines Interests Limited Partnership,
                                       General Partner

                                       By: Hines Holdings, Inc.,
                                           General Partner

                                           By: /s/ JAMES C. BUIE JR.
                                           Name: JAMES C. BUIE JR.
                                           Title: EXECUTIVE VICE PRESIDENT

                    TENANT:    COULTER PHARMACEUTICAL, INC.,
                               a Delaware corporation

                               By: /s/ WILLIAM G. HARRIS
                               Name: WILLIAM G. HARRIS
                               Title: VICE PRESIDENT & CFO



                                       48
<PAGE>

                                    EXHIBIT A

                      BASE BUILDING CONSTRUCTION AGREEMENT

        This exhibit, entitled "Base Building Construction Agreement", is and
shall constitute EXHIBIT A to the Lease Agreement, dated as of May 19, 2000, by
and between Landlord and Tenant (the "LEASE"). The terms and conditions of this
EXHIBIT A are hereby incorporated into and are made a part of the Lease.

        Subject to the terms and conditions set forth herein and in the Lease,
Landlord shall cause construction of the Building in accordance with the
procedures set forth below:

A. DEFINITIONS

        1.      "BASE BUILDING IMPROVEMENTS" shall mean a two (2) story
                building, containing approximately 50,160 square feet, all
                exterior surfaces, utilities, landscaping and paved parking, all
                in substantial compliance with those items listed on the 630
                Gateway Preliminary Specifications as "Base Building" and
                located substantially in accordance with the Site Plan.

        2.      "BASE BUILDING PLANS AND SPECIFICATIONS" is defined in Section
                B.1 below.

        3.      "BUILDING WORK COST" is defined in Section B.3 below.

        4.      "CONTRACTOR" shall mean a licensed general contractor and any
                replacement general contractors selected by Landlord in its
                reasonable discretion. Landlord and Tenant shall mutually agree
                upon the list of general contractors who shall be invited to bid
                on the construction of the Base Building Improvements. Landlord
                hereby agrees that Rudolph & Sletten shall be included on such
                list, but Landlord shall be free to select any licensed general
                contractor of its choosing as the "Contractor" hereunder.

        5.      "CONSTRUCTION WARRANTIES" is defined in Section D.2 below.

        6.      "LANDLORD'S ARCHITECT" shall mean DES Architects/Engineers or
                any replacement architect selected by Landlord in Landlord's
                reasonable discretion.

        7.      "LANDLORD'S CONTRACT" shall mean the construction contract
                entered into by and between Landlord and the Contractor for the
                construction of the Base Building Improvements and any Tenant
                Requested Base Building Improvements.

        8.      "630 GATEWAY PRELIMINARY SPECIFICATIONS" shall mean those
                preliminary specifications for construction of the Base Building
                Improvements categorized as "Base Building" and more
                particularly described on the attached SCHEDULE A-1.

        9.      "SITE PLAN" shall mean the site plan set forth on the attached
                SCHEDULE A-2 s establishing the approximate location of the
                Building. All details relating to the Project contained on the
                Site Plan, including without limitation, location of the
                Building, parking areas, ingress, egress, direction of
                driveways, and entrances are from time to time subject to



                                      A-1
<PAGE>

                change in Landlord's discretion, upon written consent from
                Tenant, which consent shall not be unreasonably withheld,
                conditioned or delayed and provided further that if Tenant fails
                to respond within five (5) business days following Landlord's
                request for consent, Tenant shall be conclusively deemed to have
                given its approval to any such change. Notwithstanding the
                foregoing, Landlord may, without the written consent of Tenant,
                change any details relating to the Project as may be required by
                any governmental agency or as necessary to comply with any
                governmental requirements or to address structural or
                unanticipated field conditions or which, in the reasonable
                discretion of Landlord, will not have a material effect on
                Tenant's use of the Premises or a material effect on the
                aesthetic appearance or impression relating to the area covered
                by the Site Plan.

        10.     "TENANT'S COSTS" is defined in Section B.6 below.

        11.     "TENANT REQUESTED BASE BUILDING IMPROVEMENTS" shall mean those
                improvements requested by Tenant in accordance with this EXHIBIT
                A that are to be incorporated into the Base Building Plans and
                Specifications.

        Capitalized terms not otherwise defined in this EXHIBIT A shall have the
meanings ascribed to them in the Lease.

B. SCHEDULE

        1.      Plans and Specifications. At Landlord's sole cost and expense,
                Landlord's Architect shall prepare on or before January 15,
                2001, plans and specifications (the "BASE BUILDING PLANS AND
                SPECIFICATIONS") for construction of the Base Building
                Improvements substantially in accordance with the 630 Gateway
                Preliminary Specifications. Tenant shall have the right to
                approve the Base Building Plans and Specifications only to the
                extent of any material deviations from the 630 Gateway
                Preliminary Specifications; provided, however, that such
                approval shall not be unreasonably withheld, conditioned or
                delayed and, provided further, that if Tenant fails to respond
                within five (5) business days following Landlord's request for
                approval, Tenant shall be conclusively deemed to have given its
                approval to the matter submitted by Landlord. Notwithstanding
                the foregoing, the Base Building Plans and Specifications are,
                from time to time, subject to change in Landlord's discretion,
                upon written consent from Tenant, which consent shall not be
                unreasonably withheld, conditioned or delayed and provided
                further that if Tenant fails to respond within five (5) business
                days following Landlord's request for consent, Tenant shall be
                conclusively deemed to have given its consent to any such
                change. Landlord may without the written consent of the Tenant
                change the Base Building Plans and Specifications as may be
                required by any governmental agency or as necessary to comply
                with any governmental requirements or to address structural or
                unanticipated field conditions or which, in the reasonable
                discretion of Landlord, will not have a material effect on
                Tenant's use of the Premises or a material effect on the
                aesthetic appearance or impression relating to the Base Building
                Improvements.

        2.      Tenant Requested Base Building Improvements. On or before
                February 15, 2001, Tenant shall deliver to Landlord's Architect
                detailed specifications for any Tenant



                                      A-2
<PAGE>

                Requested Base Building Improvements. All Tenant Requested Base
                Building Improvements shall be subject to review and approval by
                Landlord, which approval may be given or withheld in Landlord's
                reasonable discretion, to ensure, among other things, that the
                Tenant Requested Base Building Improvements are compatible with
                all other construction and all electrical, mechanical, life
                safety, and other systems within the Building. If Landlord
                disapproves the Tenant Requested Base Building Improvements,
                then within five (5) business days thereafter, Landlord shall
                meet with the Tenant's Architect (as defined in EXHIBIT B) and
                Tenant to discuss, or shall submit to Tenant's Architect and
                Tenant in writing, the reasons for Landlord's disapproval.
                Within fifteen (15) days following such meeting or submission,
                Tenant shall cause Tenant's Architect to revise the same and to
                submit new Tenant Requested Base Building Improvements to
                Landlord. The procedure set forth in this paragraph will be
                repeated as set forth above until Landlord has approved the
                Tenant Requested Base Building Improvements.

        3.      Estimate of Building Work Costs. Promptly after approval of the
                Tenant Requested Base Building Improvements, Landlord shall
                furnish Tenant with an estimate of the cost of the Tenant
                Requested Base Building Improvements (the "BUILDING WORK COST").

        4.      Tenant's Review of Building Work Costs. The Building Work Cost
                shall be subject to Tenant's approval, which approval shall not
                be unreasonably withheld, conditioned or delayed and provided
                further that if Tenant fails to respond within five (5) business
                days following Landlord's request for consent, Tenant shall be
                conclusively deemed to have given its approval to the Building
                Work Costs. If Tenant timely disapproves the Building Work Cost,
                then within five (5) business days thereafter, Tenant shall meet
                with Landlord, Contractor, Landlord's Architect and Tenant's
                Architect to discuss value engineering changes to the Tenant
                Requested Base Building Improvements. Within fifteen (15) days
                following such meeting, Tenant shall cause Tenant's Architect to
                revise the Tenant Requested Base Building Improvements and to
                submit revised Tenant Requested Base Building Improvements for
                approval by Landlord in accordance with the procedure set forth
                above and for a new Building Work Cost to be prepared by
                Landlord. The procedure set forth in this paragraph will be
                repeated until Tenant has approved the Building Work Cost.

        5.      Revision of Plans & Specifications. Following Landlord's
                approval of the Tenant Requested Base Building Improvements and
                Tenant's approval of the Building Work Cost, Landlord shall
                cause Landlord's Architect to revise the Base Building Plans and
                Specifications to incorporate the Tenant Requested Base Building
                Improvements within fifteen (15) days after receipt of Tenant's
                approval of the Building Work Cost.

        b.      Tenant's Responsibility for Cost of Tenant Requested Base
                Building Improvements. All costs associated with incorporating
                the Tenant Requested Base Building Improvements into the Base
                Building Plans and Specifications and all costs of constructing
                (including without limitation the cost of obtaining all
                necessary City approvals and permits) the Tenant Requested Base
                Building Improvements (the "TENANT'S COSTS") shall be the
                responsibility of Tenant and shall not be credited against
                Tenant's Allowance, as defined in EXHIBIT B. Tenant shall make
                progress payments to



                                      A-3
<PAGE>

                Landlord from time to time as the Tenant Requested Base Building
                Improvements are constructed. Tenant shall pay the portion of
                such progress payments attributable to Tenant's Costs to
                Landlord within ten (10) days of delivery of statements from
                Landlord to Tenant therefor. Upon receipt of such payments,
                Landlord shall make all progress payments directly to Contractor
                or subcontractors, as appropriate. Landlord shall be entitled to
                suspend or terminate construction of the Base Building
                Improvements and to declare Tenant in default in accordance with
                the terms of the Lease, if payment by Tenant to Landlord of
                Tenant's Costs has not been received as required hereunder.

C. CONSTRUCTION

        The Base Building Improvements shall be constructed, at Landlord's sole
cost and expense, by Contractor in accordance with the Base Building Plans and
Specifications, as the same may be amended or modified from time to time by
Landlord and, if required, as approved by Tenant in accordance with this EXHIBIT
A. All changes to the Base Building Plans and Specifications requiring Tenant's
approval must be evidenced by a written change order executed by Landlord and by
Tenant or each of their agents, describing the change required in the Base
Building Improvements, and the cost of such changes shall be paid in accordance
with the terms of this EXHIBIT A.

D. GENERAL

        1.      Right of Termination. Landlord and Tenant acknowledge that
                construction of the Base Building Improvements and all matters
                relating thereto are subject to Landlord obtaining all necessary
                governmental and private approvals to commence construction of
                the Base Building Improvements. Landlord shall use commercially
                reasonable efforts to obtain such approvals; however, if
                Landlord is unable to obtain the building permits necessary to
                commence construction by July 1, 2001, either party shall have
                the right to terminate the Lease by delivering written notice of
                termination to the other party on or before July 15, 2001. If
                written notice of termination is given in a timely manner, the
                Lease shall immediately terminate, except for any obligations
                which by their terms survive the termination or earlier
                expiration of the Lease. If no such notice of termination is
                given, the Lease shall remain in full force and effect.
                Notwithstanding anything herein to the contrary, Landlord shall
                not be liable to Tenant for any loss or damage resulting from
                any delay in constructing or developing the Base Building
                Improvements, nor shall such failure affect the obligations of
                Tenant under the Lease, except as otherwise set forth in the
                Lease.

        2.      Construction Warranties. Landlord shall obtain from Contractor,
                and shall request Contractor to obtain from all subcontractors
                and material suppliers, warranties (collectively, "CONSTRUCTION
                WARRANTIES") for all components of the Base Building
                Improvements for which warranties are customarily provided in
                the construction industry and Landlord shall enforce the
                Construction Warranties as reasonably requested by Tenant.



                                      A-4
<PAGE>

        3.      Landlord's Covenants. Subject to the terms and conditions of the
                Lease, Landlord covenants that (a) the Base Building
                Improvements shall be constructed in compliance with all
                applicable building code requirements in effect and being
                actively enforced by the City of South San Francisco on the date
                the applicable building permits for construction of the Base
                Building Improvements were issued to Contractor and
                substantially in accordance with the Base Building Plans and
                Specifications and (b) that the Base Building Improvements shall
                be free from material latent defects in design, materials and
                workmanship; provided however, Landlord shall have no liability
                under this paragraph unless failure to comply with the terms
                hereof materially adversely affect Tenant's use of the Premises.
                Any claims by Tenant under clause (a) above, shall be made in
                writing not later than one (1) year after the Commencement Date
                and any claims by Tenant under clause (b) above, shall be made
                in writing not later than the earlier of twelve (12) years after
                the Commencement Date or termination of the Lease. In the event
                Tenant fails to deliver a written claim to Landlord on or before
                such dates, then Landlord shall be conclusively deemed to have
                satisfied its obligations under this paragraph. The covenants
                contained in this paragraph are subject to Paragraph 39 of the
                Lease and are made specifically and exclusively for the benefit
                of the original Tenant.



                                      A-5

INITIALS:

TENANT: /s/ WGH
        -----------

LANDLORD: /s/ JCB
          ---------
<PAGE>

                                  SCHEDULE A-1

                     630 GATEWAY PRELIMINARY SPECIFICATIONS

<TABLE>
<CAPTION>
Description                                                                           Base Building     Tenant
-----------                                                                           -------------     ------
<S>                                                                                   <C>               <C>
Sitework

-   All necessary fees and permits for Base Building work.                                 X

-   All grading of the site to predetermined grades per DES Architects plans               X

-   Installation of all necessary underground utilities, storm drain, sewer, catch
    basins, drain inlets, common trench, water, electricity, cable television and
    gas meter per DES Architects documents.                                                X

-   Installation of all offsite and onsite curbs, gutters and sidewalks as shown on
    Des Architect construction documents.                                                  X

-   Installation of all irrigation and landscaping per DES Architect's plans.              X

-   All area drains in landscaping areas, which shall be connected to the storm
    drain system if required by DES Architects.                                            X

-   installation of separate water and electrical meters for all common area
    landscaping.                                                                           X

-   Installation of code required informational and directional signage.                   X

-   Illuminated and non-illuminated interior signage by tenant.                                            X

-   Illuminated monument signage and on building identification signage as reviewed
    by Tenant.                                                                             X

-   Striping of all parking areas per DES Architects documents.                            X

-   Installation of all trash screens as required by Planning Department of the City
    of South San Francisco.                                                                X

-   Installation of all exterior lighting for standard use with a minimum coverage
    in both parking areas and walkways of not less than one foot candle.                   X

    Structure

-   All necessary fees and permits for Base Building work.                                 X

-   All work necessary per code to make the Base Building handicap accessible.             X

-   Minimum 5" slab on grade in conformance with specifications and recommendations
    of Base Building geotechnical and engineering consultants. Finish shall be
    smooth.                                                                                X

-   Sand fill and moisture barrier under slab on grade as recommended by DES
    Architects.                                                                            X

-   Exterior concrete walls shall be sandblasted and sealed.                               X

-   All structural steel shall be erected per DES Architect's specifications.              X

-   All structural steel shall not be fireproofed unless required by local codes.          X

-   Second floor decking shall be galvanized metal with a lightweight concrete
    topping slab. Finish SHALL be smooth.                                                  X

-   All exterior vision glass shall be 1/4" thick with reflective coating.                 X

-   Roof membrane SHALL be 4-ply built-up system with a mineral fiber cap sheet.           X
</TABLE>



                                     A-1-1
<PAGE>

<TABLE>
<CAPTION>
Description                                                                           Base Building     Tenant
-----------                                                                           -------------     ------
<S>                                                                                   <C>               <C>
-   All required condensate lines to be installed and terminated at the nearest roof
    drain for Base Building equipment                                                      X

-   Roof drains per plan with drain lines tying into the storm drain system.
    Scuppers for overflow to be provided if required by code.                              X

-   Convenience outlets, as required by code, on the roof.                                 X

-   Floor system shall be designed to a minimum of 45 Lbs. per square foot for
    office space and a minimum of 100 lbs. per square foot on ground floor for lab
    space.                                                                                 X

-   Roof insulation to meet minimum energy code.                                           X

-   Roof live load to accommodate 50 lb. dead load and necessary reinforcement for
    additional lab related mechanical equipment in areas indicated on plan.                X

-   Required second floor penetrations, including blockouts, as shown on Tenant
    Improvement drawings for mechanical, electrical and plumbing trades and roof
    hatch.                                                                                 X

-   Required roof penetrations, including blockouts, as shown on tenant improvement
    drawings for tenant required mechanical, electrical and plumbing work                                  X

-   All roofing inspections.                                                               X

-   Top of slab on grade to top of second floor slab shall be 15'-0". Top of second
    floor slab to top of roof muses shall be 13'-0".                                       X

-   All exterior doors, except entrance doors, shall be hollow core metal with metal
    jambs as shown in schematic documents with hardware as required by Tenant.             X

-   One 12'-0" x 12'-0"steel rollup door shall be installed per Tenant specifications
    for delivery area.                                                                     X

-   Front entry doors shall be a pair of 3'-0" x 8'-0" fully supported, balanced
    aluminum and glass doors with hardware approved as required by Tenant. '               X

-   All interior stairs as required by code, but not less than two per building. All
    stairs shall be metal pan with concrete rill.                                          X

-   Stair carpeting, if required, to be provided by tenant.                                                X

-   All interior stair handrails shall be primed. Proper backing shall be installed.       X

-   All stairwells shall be sheetrocked, taped and ready for paint.                        X

-   All stairwells shall include code required lighting.                                   X

-   All required base building life safety signage as required by code.                    X

-   All equipment platforms shall have a sheetmetal cap and minimum 3" apron around
    the perimeter. Six bay equipment platform as indicated on plan ready to receive
    framing for equipment.                                                                 X

-   One hydraulic passenger elevator, including all necessary wiring and equipment,
    with a capacity of not less than 2,500 Lbs. and a minimum speed of 100' per
    minute.                                                                                X

-   A complete elevator cab that is the manufacturer's standard                            X

-   Base Building to accommodate a 9'-0" finished ceiling height on both floors.           X
</TABLE>



                                     A-1-2
<PAGE>

<TABLE>
<CAPTION>
Description                                                                           Base Building     Tenant
-----------                                                                           -------------     ------
<S>                                                                                   <C>               <C>
-   All exterior concrete walls shall be finished on the interior with lightweight
    metal studs, insulation and sheetrock, taped with a smooth finish.                                     X

-   Master keyed exterior locks.                                                           X

-   Individual keying per tenant specifications.                                                           X

-   A complete fire sprinkler system, sized to meet code per the interior
    improvement design. This system shall be complete and operational including
    required drops to the suspended ceiling in tenant finished areas. The system
    shall include, but is not limited to, valves, dry stand pipes, monitoring
    stations, aennciators, horns and storage tanks, if required by code.                                   X

-   Roof access ladder and hatch in one stairwell.                                         X

-   Patio furniture.                                                                                       X

Utilities and Backbone Systems

-   2,000 amp. 277/480 volt, 3 phase electrical service switchgear and meter and
    switch center room.                                                                    X

-   Separate electrical meter, panel and time clock for Parking lot lighting and
    irrigation.                                                                            X

-   Telephone trunk lines to the interior telephone room sufficient in size to
    accommodate the building.                                                                              X

-   Two PVC conduits, minimum of 4" between the second and third buildings for
    telephone and data.                                                                    X

-   Required water service for sprinkler system.                                           X

-   A minimum of 2" domestic water service to building. There shall be a separate
    meter for this water line and it shall terminate inside the building below the
    second floor.                                                                          X

-   A minimum 4" natural gas service building. There shall be a separate meter for
    this service and it shall terminate inside the building below the second floor.                        X

-   As required, a 6" cast iron, sanitary sewer gut line the entire length of the
    building. This gut line shall have, at a minimum, one cleanout at the end of its
    run, one in the restroom core and one cleanout at the entrance to the building.
    Exact location of this gut line shall be determined by tenant.                                         X

-   All necessary electrical and fire sprinkler rooms, sized to accommodate Tenant
    requirements, shall be complete with light weight metal studs, metal doors and
    jambs, required ventilation through the roof membrane, lighting, convenience
    outlets and sheetrock, taped and textured.                                                             X

MEP

-   All required electrical to base building equipment                                     X

-   All backboards as required by Tenant.                                                                  X

-   All required electrical outlets and lighting to complete base building
    requirements.                                                                          X

-   Smoke detectors as required by code.                                                                   X

-   All required roof walk pads, conduit supports, and penetrations for equipment.                         X
</TABLE>



                                     A-1-3
<PAGE>

<TABLE>
<CAPTION>
Description                                                                           Base Building     Tenant
-----------                                                                           -------------     ------
<S>                                                                                   <C>               <C>
-   All sheetmetal necessary to provide moisture protection and flashing details for
    Base Building equipment. (None anticipated)                                            X

-   All necessary seismic restraints on Base Building equipment. (None anticipated)        X

-   A centrally located, gas hot water heater large enough to accommodate all of the
    base building and tenant requirements including hot water to all labs.                                 X

-   A mechanical chiller system, sized to accommodate 50,000 square feet of office
    space.                                                                                                 X

-   All ductwork and penetrations necessary to provide both supply and return air to
    each floor, elevator cores and lobby restrooms shall be provided All necessary
    fire and smoke dampers shall be included for Base Building work. Restrooms,
    elevator cores, lobby and stairwells shall be complete.                                                X

-   All ductwork and roof mounted fans necessary to provide proper ventilation in
    the restrooms, electrical closets and elevator machine room.                                           X

-   Screening of roof mounted equipment. Roof screen as shown on roof plan.                X

-   Exhaust ducts, through the roof, for lab ventilating as specified by Tenant.                           X

-   Hose bib near delivery areas.                                                                          X

Lobby Area

-   Architect design fees associated with the lobby area.                                                  X

-   Two story height with skylight, visibility to stairwell and a catwalk and
    overlook at the second floor level.                                                                    X

-   Area of Lobby to be 30' X 30'. Landlord to contribute $50,000 for this work.                           X

-   All walls sheetrocked, taped with a smooth finish. If Tenant so desires, all
    walls will be prepared and ready to accept wallcovering.                                               X

-   Electrical outlets, telephone outlets and data outlets necessary to accommodate
    the Tenant's proposed lobby layout.                                                                    X

-   Ceramic tile entry, 8'-0" wide, from the front doors to the reception counter.
    All other areas to be carpet, a 36 oz loop minimum, and if desired by Tenant,
    with a border.                                                                                         X

-   6" or 2" rubber base in all areas.                                                                     X

-   Entry doors to be a pair of aluminum glass with hardware as required by tenant.        X

-   All doors off of lobby to be wood grain, 3'-0" X 8'-0" minimum in height.
    Hardware to be selected by tenant.                                                                     X

-   All HVAC to be complete.                                                                               X

-   All Base Building areas to be handicap accessible per code.                            X

-   All finishes by Tenant.                                                                                X

-   Ceiling to be sheetrock, taped and textured.                                                           X

-   Lighting to include, but not be limited to, down lights, recessed wall washers,
    recessed parabolic or halogen.                                                                         X

-   Wallcovering on all walls if so desired by Tenant.                                                     X

-   Fully painted to Tenant specifications.                                                                X
</TABLE>



                                     A-1-4
<PAGE>

<TABLE>
<CAPTION>
Description                                                                           Base Building     Tenant
-----------                                                                           -------------     ------
<S>                                                                                   <C>               <C>
Elevator Lobbies

-   Sheetrock walls and ceiling, taped with a smooth finish.                                               X

-   Ceiling to have a multiple coffer with lighting behind.                                                X

-   Electrical outlets to support work required in the area                                                X

-   Stainless steel jambs and head around elevator opening on ground floor                X

-   Painted hollow metal jambs and head on 2nd floor.                                     X

-   Nickel/silver threshold and elevator entrance.                                        X

-   Grout under elevator thresholds.                                                      X

-   Carpet, 36 oz loop minimum, and if desired by Tenant, with a border, including
    in elevator cab.                                                                                       X

-   6" or 2" rubber base at all areas.                                                                     X

-   Magnetic hold opens on all lobby doors if required by code.                                            X

-   Lobby door to be wood grain, full height, with hardware reviewed by Tenant.                            X

-   Lighting to include recessed down lights, recessed lights or wall washers.                             X

-   Fully painted to Tenant specifications.                                                                X

-   All HVAC to be complete.                                                                               X

-   All elevator lobby areas to have a one hour rating if required by code.                                X

Restrooms

-   sheetrock walls taped with a smooth finish. A cofer shall be installed over
    the vanity area.                                                                      X

-   Ceilings to be drywall.                                                               X

-   Ceramic tile floors and wainscot on all walls.                                        X

-   All floors sloped to a floor drain.                                                   X

-   Light cove with egg crate louver over stalls and urinals.                             X

-   Provide janitor closets on each floor adjacent to restrooms.                          X

-   Provide sinks in janitor closets.                                                     X

-   Recessed lighting at entry, sinks and outside stalls.                                 X

-   All partitions to be metal and hung from the ceiling.                                 X

-   All toilets and urinals to be hung from wall.                                         X

-   Plastic laminate counter tops over moisture resistant plywood with 5" lipped
    apron and 6" splash (to be ADA compliant).                                            X

-   Full length mirror with polished stainless steel frame.                               X

-   Provide insulation for hot and cold water pipes.                                      X

-   Minimum toilet accessories to include, but not limited to, sinks, stainless
    faucets, toilets, urinals, recessed paper towel dispensers with integral waste,
    counter mounted soap dispensers, sanitary napkin dispenser, seat cover
    dispenser, toilet tissue dispenser, handicap grab bars and partition mounted
    coat hooks.                                                                           X
</TABLE>



                                     A-1-5
<PAGE>

<TABLE>
<CAPTION>
Description                                                                           Base Building     Tenant
-----------                                                                           -------------     ------
<S>                                                                                   <C>               <C>
-   Paint above wainscot as directed by Tenant.                                           X

-   Vestibules and finishes.                                                              X
</TABLE>



                                     A-1-6
<PAGE>

                                  SCHEDULE A-2



                                     [MAP]

<PAGE>
                                    EXHIBIT B

                         PREMISES CONSTRUCTION AGREEMENT

        This exhibit, entitled "Premises Construction Agreement", is and shall
constitute Exhibit B to the Lease Agreement, dated as of May 19, 2000, by and
between Landlord and Tenant (the "LEASE"). The terms and conditions of this
EXHIBIT B are hereby incorporated into and are made a part of the Lease.

        Subject to the terms and conditions set forth herein and in the Lease,
Landlord shall allow the construction or installation of the improvements in the
interior of the Building in accordance with the procedures set forth below:

A.      DEFINITIONS

        1.      "APPROVED PLANS" is defined in Section B.6 below.

        2.      "CONTRACTOR" shall mean Rudolph & Sletten or another licensed
                general contractor designated by Tenant and approved by
                Landlord, which approval shall be given or withheld in
                Landlord's reasonable discretion.

        3.      "ESTIMATED WORK COST" is defined in Section B.3 below.

        4.      "EXCESS TENANT IMPROVEMENTS COSTS" is defined in Section B.7
                below.

        5.      "FINAL COST QUOTATION" is defined in Section B.7 below and shall
                include all costs associated with the Tenant Improvements,
                including without limitation, costs of all tenant improvement
                work; architectural and engineering fees; governmental agency
                fees for permits, licenses and inspections; construction fees,
                including, without limitation, general contractors' overhead and
                supervision fees; Landlord's administration fee of Fifty
                Thousand One Hundred Sixty Dollars ($50,160) (based on $1.00
                multiplied by the Premises Square Footage); and such other costs
                as may be reasonably incurred by Landlord in connection with
                such construction.

        6.      "PRELIMINARY PLANS" is defined in Section B.1 below.

        7.      "TENANT'S ALLOWANCE" shall mean an amount equal to One Million
                Five Hundred Ninety-Six Thousand Five Hundred Ninety-Three
                Dollars ($1,596,593) (based on $31.83 multiplied by the Premises
                Square Footage), which amount shall, except as otherwise
                provided in this EXHIBIT B, be paid by Landlord toward the cost
                of completion of the Tenant Improvements and related design,
                engineering, governmental, overhead, supervision and
                administration fees and costs (collectively, the "TENANT
                IMPROVEMENT COST"). Notwithstanding the foregoing, no portion of
                the Tenant's Allowance shall be paid by Landlord toward the cost
                of the Tenant Requested Base Building Improvements, or Tenant
                Improvements that constitute furniture, equipment or trade
                fixtures or result in changes to the Base Building Improvements.
                If the Tenant Improvement Cost exceeds the Tenant's Allowance,
                the difference shall be paid by Tenant in accordance with this
                EXHIBIT B.




                                      B-1
<PAGE>

        8.      "TENANT'S ARCHITECT" shall mean CAS Architects, or such other
                licensed architect designated by Tenant and subject to
                Landlord's prior approval, which approval shall be given or
                withheld in Landlord's reasonable discretion.

        9.      "TENANT'S CONTRACT" shall mean the construction contract entered
                into by and between Tenant and the Contractor for the
                construction of the Tenant Improvements.

        10.     "TENANT IMPROVEMENTS" shall mean all improvements made to the
                Premises pursuant to the Approved Plans.

        Capitalized terms not otherwise defined in this EXHIBIT B shall have the
meanings ascribed to them in the Lease.

B.      SCHEDULE

        1.      Tenant shall cause Tenant's Architect to furnish to Landlord on
                or before April 15, 2001, preliminary space plans and
                specifications (the "PRELIMINARY PLANS"). Tenant shall be
                responsible for all costs associated with the Preliminary Plans
                (collectively, the "PRELIMINARY DESIGN COSTS"), including any
                revisions required by Section B.2 hereunder; provided, however,
                Tenant shall be reimbursed by Landlord out of the Tenant's
                Allowance for the Preliminary Design Costs reasonably incurred
                upon delivery to Landlord of invoices, receipts and other
                documents reasonably required to substantiate such costs.

        2.      The Preliminary Plans shall be subject to Landlord's approval,
                which approval shall not be unreasonably withheld, conditioned
                or delayed. If Landlord disapproves the Preliminary Plans, then
                within five (5) business days thereafter, Landlord shall meet
                with the Tenant's Architect and Tenant to discuss, or shall
                submit to the Tenant's Architect and Tenant in writing, the
                reasons for Landlord's disapproval. Within fifteen (15) days
                following such meeting or submission, Tenant shall cause the
                Tenant's Architect to revise the same and to submit new
                Preliminary Plans to Landlord. The same procedure set forth in
                this paragraph will be repeated as set forth above until
                Landlord has approved the Preliminary Plans.

        3.      Promptly after approval of the Preliminary Plans, Tenant shall
                cause Contractor to furnish Landlord with an estimate of the
                cost of the Tenant Improvements as shown on the Preliminary
                Plans and Landlord shall in turn provide Tenant with an estimate
                of the cost of the Tenant Improvements, including, without
                limitation, estimates of the following costs: architectural and
                engineering fees, governmental agency fees for permits, licenses
                and inspections, overhead and supervision fees, and Landlord's
                administrative fees (the "ESTIMATED WORK COST"). The Estimated
                Work Cost shall separately itemize the cost of changes to the
                Base Building Improvements for those Tenant Improvements that
                will necessitate changes in the Base Building Improvements.

        4.      The Estimated Work Cost shall be subject to Tenant's approval,
                which approval shall not be unreasonably withheld, conditioned
                or delayed and provided further that if Tenant fails to respond
                within five (5) business days following Landlord's delivery of




                                      B-2
<PAGE>

                the Estimated Work Cost, Tenant shall be conclusively deemed to
                have given its approval of the Estimated Work Cost. If Tenant
                timely disapproves the Estimated Work Cost, then within five (5)
                business days thereafter, Tenant shall meet with Landlord,
                Contractor and Tenant's Architect to discuss value engineering
                changes to the Preliminary Plans. Within fifteen (15) days
                following such meeting, Tenant shall cause Tenant's Architect to
                revise the Preliminary Plans and to submit new Preliminary Plans
                for approval by Landlord in accordance with the procedure set
                forth above and for a new Estimated Work Cost to be prepared by
                Landlord. The procedure set forth in this paragraph will be
                repeated until Tenant has approved the Estimated Work Cost.

        5.      Following Landlord's approval of the Preliminary Plans and
                Tenant's approval of the Estimated Work Cost, Tenant shall cause
                Tenant's Architect to prepare detailed construction drawings and
                specifications (the "WORKING DRAWINGS") for the Tenant
                Improvements based strictly upon the Preliminary Plans, except
                as otherwise agreed in writing by Landlord and Tenant. The
                Working Drawings shall be completed within fifteen (15) business
                days after approval of the Preliminary Plans and Estimated Work
                Cost, but in no event later than June 15, 2001.

        6.      The Working Drawings shall be subject to Landlord's approval,
                which approval shall not be unreasonably withheld, conditioned
                or delayed. If Landlord disapproves the Working Drawings, then
                within five (5) business days thereafter, Landlord shall meet
                with Tenant's Architect and Tenant to discuss, or shall submit
                to the Tenant's Architect and Tenant in writing, the reasons for
                Landlord's disapproval. Within fifteen (15) days following such
                meeting or submission, Tenant shall cause Tenant's Architect to
                revise the same and to submit new Working Drawings to Landlord,
                and the same procedure will be repeated as set forth above until
                Landlord has approved the Working Drawings (the "APPROVED
                PLANS"). The reasonable costs of preparing the Working Drawings,
                together with any revisions thereto, may be paid by Landlord to
                Tenant from Tenant's Allowance. Upon approval of the Working
                Drawings, Landlord shall deliver to Tenant a list of Tenant
                Improvements to be removed by Tenant, at Tenant's cost and
                expense in accordance with Paragraph 11 of the Lease, upon
                expiration of the Term or earlier termination of the Lease.
                Notwithstanding the foregoing, during the preparation of the
                Working Drawings, Landlord shall, upon Tenant's request, advise
                Tenant of items that will be required to be removed pursuant to
                the previous sentence.

        7.      Within ten (10) business days after Landlord's approval of the
                Approved Plans, Tenant shall cause Contractor to furnish to
                Landlord a cost estimate for the Tenant Improvements based upon
                the Approved Plans and Landlord shall in turn provide Tenant
                with a final cost quotation for the Tenant Improvements (the
                "FINAL COST QUOTATION"). If the Final Cost Quotation is greater
                than the Tenant's Allowance, Tenant shall be responsible for the
                difference between the Tenant's Allowance and the Final Cost
                Quotation (the "EXCESS TENANT IMPROVEMENTS COST").

        8.      Landlord and Tenant shall make progress payments on a pro rata
                basis (in the proportion that the Tenant's Allowance paid by
                Landlord and the Excess Tenant




                                      B-3
<PAGE>

                Improvements Cost paid by Tenant bear to the Final Cost
                Quotation) from time to time as the Tenant Improvements are
                constructed in the Premises. Tenant shall pay its pro rata share
                of any progress payments directly to Contractor or
                subcontractors, as appropriate, and Landlord shall pay its pro
                rata share of any progress payments directly to Contractor or
                subcontractors, as appropriate. Landlord shall be entitled to
                suspend or terminate construction of the Tenant Improvements and
                to declare Tenant in default in accordance with the terms of the
                Lease, if payment by Tenant of Tenant's pro rata share of any
                progress payment has not been received by Contractor when due,
                as required hereunder. Moreover, Landlord shall not be required
                to pay its pro rata share of any progress payment until such
                time as Landlord receives from Contractor an unconditional lien
                waiver as to each progress payment that has previously been made
                and a conditional lien waiver for the current progress payment.
                All lien waivers shall comply with California law regarding
                materialmen and mechanic's liens. Notwithstanding the
                foregoing, Tenant may, at Tenant's option and upon reasonable
                prior written notice to Landlord, pay the full amount of the
                progress payment and, subject to Landlord's receipt of the lien
                waivers specified above, obtain reimbursement from Landlord for
                Landlord's pro rata share promptly after Tenant's delivery to
                Landlord of a written demand for such pro rata share owing.

C.      TENANT IMPROVEMENT CONSTRUCTION

        1.      All Tenant Improvements to be constructed or installed in the
                Premises shall be performed by Contractor in accordance with the
                Approved Plans, subject to any changes agreed to by Landlord and
                Tenant in writing. Landlord shall have no obligation to Tenant
                for defects in design, workmanship or materials in connection
                with the Tenant Improvements. Any changes to the Approved Plans
                shall require the written approval of Landlord and Tenant, which
                approval shall not be unreasonably withheld, conditioned or
                delayed. All such changes must be evidenced by a written change
                order executed by Landlord and Tenant or their agent describing
                the change required in the Approved Plans, and the cost of such
                changes shall be paid in accordance with the terms of this
                EXHIBIT B.

        Z.      Landlord shall coordinate construction of the Tenant
                Improvements by Contractor with the construction of the Base
                Building Improvements by Contractor in the most efficient manner
                reasonably possible for the timely completion of the Base
                Building Improvements and the Tenant Improvements. Landlord and
                Tenant shall each use good faith efforts to reasonably resolve
                any issues or conflicts that may arise during the course of
                constructing the Tenant Improvements and the Base Building
                Improvements. Entry by Contractor in accordance with this
                EXHIBIT B shall not constitute Tenant's occupancy of the
                Premises under Paragraph 3 of the Lease; however, all terms and
                conditions of the Lease shall apply to Contractor's occupancy of
                and work within the Premises.

        3.      In addition to and without limitation on the requirements set
                forth in the Lease, Tenant shall ensure that, with respect to
                the work to be performed as part of Tenant's Contract,
                Contractor and all subcontractor(s) procure and maintain in full
                force and effect during the course of construction a "broad
                form" commercial general liability and property




                                      B-4
<PAGE>

                damage policy of insurance naming, Landlord, Tenant and
                Landlord's lenders as additional insureds. The minimum limit of
                coverage of the aforesaid policy shall be in the amount of not
                less than Three Million Dollars ($3,000,000) for injury or death
                of one person in any one accident or occurrence and in the
                amount of not less than Three Million Dollars ($3,000,000) for
                injury or death of more than one person in any one accident or
                occurrence, and shall contain a severability of interest clause
                or a cross liability endorsement. Such insurance shall further
                insure Landlord and Tenant against liability for property damage
                of at least One Million Dollars ($1,000,000).

D.      TERM COMMENCEMENT

        1.      Notwithstanding anything in the Lease to the contrary, except as
                otherwise provided in D.2 and D.3 below, the commencement date
                of the Lease (the "COMMENCEMENT DATE") shall be no later than
                November 30, 2001. The Commencement Date shall not be adjusted
                due to delays caused by Tenant or any employee, agent or
                representative of Tenant ("TENANT DELAYS"), including, without
                limitation, delays caused by (i) failure to furnish information
                in accordance with this EXHIBIT B or EXHIBIT A of the Lease;
                (ii) Tenant's request for any special, long lead time materials
                or installations as part of the Tenant Improvements or the
                Tenant Requested Base Building Improvements; (iii) Tenant's
                changes in the Approved Plans; (iv) any changes initiated by
                reason of the disapproval of any plans or drawings or any cost
                proposals or authorizations resulting in the preparation of
                revised plans, drawings, cost proposals or authorizations beyond
                the second submission to Landlord for approval; (v) field
                changes to construction work; (vi) the delivery, installation or
                completion of the Tenant Improvements work performed by
                Contractor; (vii) Tenant's request for any Tenant Requested Base
                Building Improvements, as defined in EXHIBIT A of the Lease or
                any delay in delivering the Tenant Requested Base Building
                Improvements beyond the date set forth in Section B.2 of EXHIBIT
                A; or (viii) any other act or omission of Tenant.

        2.      Except as may be otherwise specifically provided herein or in
                the Lease, time periods for either party's performance under any
                provisions of this EXHIBIT B, shall be extended for periods of
                time during which such party is prevented due to circumstances
                beyond such party's control, including, without limitation,
                strikes, embargoes, governmental regulations, delays in
                obtaining permits or materials, acts of God, war, civil
                commotion or other strife ("FORCE MAJEURE EVENTS"). Each party
                shall use reasonable efforts to mitigate the effect of any Force
                Majeure Event upon such party's performance hereunder. In
                addition, if Landlord's Architect fails to complete the Base
                Building Plans and Specifications on or before the date set
                forth in Section B.1 of EXHIBIT A to the Lease for reasons other
                than Tenant Delays, then the Commencement Date shall be delayed
                by one (1) day for each day of delay in the completion of the
                Base Building Plans and Specifications.

        3.      Intentionally deleted.

        4.      If for any reason Landlord cannot perform any covenant contained
                in this EXHIBIT B or in the Lease related to the work described
                in this EXHIBIT B, the Lease shall not be void or voidable nor
                shall Landlord be liable to Tenant for any loss or damage
                resulting




                                      B-5
<PAGE>

                therefrom, nor shall such failure affect the obligations of
                Tenant under the Lease, except as otherwise specifically
                provided in the Lease.

E.      GENERAL

        1.      All drawings, space plans, plans and specifications for any
                improvements or installations in the Premises are expressly
                subject to Landlord's prior written approval, which approval
                shall not be unreasonably withheld, conditioned or delayed. Any
                approval by Landlord of any drawings, plans or specifications
                prepared on behalf of Tenant including, without limitation, any
                Preliminary Plans, Working Drawings or Approved Plans, or any
                revisions thereto, shall not in any way bind Landlord, create
                any responsibility or liability on the part of the Landlord for
                the completeness of the same, their design sufficiency or
                compliance with applicable statutes, ordinances or regulations
                or constitute a representation or warranty by Landlord as to the
                adequacy or sufficiency of such drawings, plans or
                specifications, or the improvements to which they relate, but
                such approval shall merely evidence the consent of Landlord to
                such drawings, plans or specifications.

        2.      Any failure by Tenant to pay any amounts due hereunder shall
                have the same effect under the Lease as a failure to pay Rent
                and any failure by Tenant to perform any of its other
                obligations hereunder shall be subject to Paragraph 24 of the
                Lease.

INITIALS:

TENANT: /s/ W.B.H.
       -------------
LANDLORD: /s/ J.C.B.
         -----------




                                      B-6
<PAGE>

                                    EXHIBIT C

                                GUARANTY OF LEASE

        THIS GUARANTY OF LEASE ("GUARANTY") is made as of _________________,
_______, by _____________________, a ___________________ corporation
("GUARANTOR"), to _____________________, a ___________________ ("LANDLORD"),
with reference to the following facts:

        A. Landlord has previously entered into a Lease Agreement ("LEASE") with
_____________________, a ___________________ ("TENANT"), for certain premises
located at the Gateway Technology Center, South San Francisco, California, as
more particularly described in the Lease.

        B. Guarantor is willing to execute this Guaranty for the express and
intended purpose of inducing Landlord to replace existing Security granted
Landlord by Tenant under the Lease. Landlord would not agree to replace such
Security but for the execution and delivery of this Guaranty by Guarantor.

        C. Guarantor is affiliated with Tenant and will benefit from the
execution of the Lease. Guarantor is executing this Guaranty in consideration of
that anticipated benefit.

        NOW, THEREFORE, for good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged and agreed, Guarantor hereby agrees
as follows:

        1. Guaranty. Guarantor does hereby absolutely and unconditionally,
jointly and severally guarantee to Landlord the prompt payment of all amounts
that Tenant, or any assignee of the Lease, may at any time owe under the Lease,
any extensions, renewals or modifications thereof, and further guarantees to
Landlord the full, prompt and faithful performance by Tenant, or any assignee of
the Lease, of each and all of the covenants, terms, and conditions of the Lease,
or any extensions, modifications or renewals thereof, to be hereafter performed
and kept by Tenant, or any assignee of the Lease (all such obligations of Tenant
under the Lease are referred to as "TENANT'S OBLIGATIONS"). Guarantor hereby
agrees to indemnify, defend and hold Landlord harmless from any and all
liabilities, losses, damages, costs and expenses (including, but not limited to,
reasonable attorneys' fees), by reason of a breach or default under the Lease by
Tenant or any assignee of the Lease.

        2. Independent Obligations. Guarantor's obligations hereunder are
independent of the obligations of Tenant, or any assignee of the Lease, and a
separate action or actions may be brought and prosecuted against Guarantor
whether or not action is brought against Tenant or any such assignee or whether
or not Tenant or any such assignee be joined in any such action or actions.

        3. Rights of Landlord. Guarantor authorizes Landlord, without notice or
demand and without affecting its liability hereunder, from time to time to (a)
extend, accelerate, or otherwise change the time for any payment provided for in
the Lease, or any covenant, term or condition of the Lease, impair or suspend
the Landlord's remedies or rights against Tenant in connection with the Lease,
and to consent to any assignment, subletting or reassignment of the Lease; (b)
take




                                      C-1
<PAGE>

and hold security for any payment provided for in the Lease or for the
performance of any covenant, term or condition of the Lease, or exchange, waive
or release any such security; and (c) apply such security and direct the order
or manner of sale thereof as Landlord in its discretion may determine. Landlord
may, without consideration to or consent of the Guarantor, assign this Guaranty,
the Lease, or the rents and other sums payable thereunder; provided, however,
that Landlord shall promptly after any such assignment notify Guarantor of such
action. Notwithstanding any termination, renewal, extension or holding over of
the Lease, this Guaranty shall continue until all of Tenant's Obligations have
been fully and completely performed by Tenant or any assignee of the Lease.

        Guarantor shall not be released by any act or event which might, but for
this provision of this Guaranty, be deemed a legal or equitable discharge of a
surety, or by reason of any waiver, extension, modification, forbearance or
delay or other act or omission of Landlord or its failure to proceed promptly or
otherwise as against Tenant or Guarantor, or by reason of any action taken or
omitted or circumstance which may or might vary the risk or affect the rights or
remedies of Guarantor as against Tenant, or by reason of any further dealings
between Tenant and Landlord, whether relating to the Lease or otherwise, and
Guarantor hereby expressly waives and surrenders any defense to its liability
hereunder based upon any of the foregoing acts, omissions, things, agreements,
waivers or any of them; it being the purpose and intent of this Guaranty that
the obligations of Guarantor hereunder are absolute and unconditional under any
and all circumstances.

        Guarantor further agrees that to the extent Tenant or Guarantor makes
any payment to Landlord in connection with Tenant's Obligations and all or any
part of such payment is subsequently invalidated, declared to be fraudulent or
preferential, set aside or required to be repaid by Landlord or paid over to a
trustee, receiver or any other entity, whether under any bankruptcy act or
otherwise (any such payment is hereinafter referred to as a "PREFERENTIAL
PAYMENT"), then this Guaranty shall continue to be effective or shall be
reinstated, as the case may be, and, to the extent of such payment or repayment
by Landlord, Tenant's Obligations or part thereof intended to be satisfied by
such Preferential Payment shall be revived and continued in full force and
effect as if said Preferential Payment had not been made.

        4. Waiver of Defenses. Guarantor waives (a) any right to require
Landlord to (i) proceed against Tenant or any other person or entity, (ii)
proceed against or exhaust any security held from Tenant or Guarantor, (iii)
pursue any other remedy in Landlord's power which Guarantor cannot itself
pursue, and which would lighten its burden; (b) all statutes of limitations as a
defense to any action brought against Guarantor by Landlord to the fullest
extent permitted by law; (c) any defense based upon any legal disability of
Tenant, or any assignee of the Lease, or any discharge or limitation of the
liability of Tenant, or any assignee of the Lease, to Landlord, whether
consensual or arising by operation of law or any bankruptcy, reorganization,
receivership, insolvency, or debtor-relief proceeding, or from any other cause;
(d) presentment, demand, protest, and notice of any kind, except as specifically
provided below; and (e) any defense based upon or arising out of any defense
which Tenant, or any assignee of the Lease, may have to the payment or
performance of any part of Tenant's Obligations. Guarantor waives all demands
upon and notices to Tenant, or any assignee of the Lease, and to Guarantor
(except as specifically provided below), including demands for performance,
notices of non-performance, notices of non-payment and notice of acceptance of
this Guaranty. Landlord shall




                                      C-2
<PAGE>

give three (3) days prior written notice to Guarantor of Landlord's demand for
Guarantor to perform under this Guaranty and Guarantor hereby agrees to so
perform within said time period. If Guarantor fails to so perform within said
time period, Landlord may enforce this Guaranty in accordance with all of
Landlord's rights and remedies provided in this Guaranty, at law or in equity.
Notwithstanding anything in the Guaranty to the contrary, failure by Landlord to
give prior notice of demand shall in no way relieve Guarantor of any of its
obligations under this Guaranty.

        5. Waiver of Subrogation.

        (a) Notwithstanding any other provision of this Guaranty to the
contrary, until the obligations of Tenant under the Lease are fully performed
and paid, Guarantor hereby waives any claims or other rights which Guarantor may
now have or hereafter acquire against Tenant or any other guarantor of all or
any of Tenant's Obligations, which claims or other rights arise from the
existence or performance of Guarantor's obligations under this Guaranty or the
Lease (all such claims and rights are referred to as "GUARANTOR'S CONDITIONAL
RIGHTS"), including, without limitation, any right of subrogation,
reimbursement, exoneration, contribution, or indemnification, any right to
participate in any claim or remedy of Landlord against Tenant or any collateral
which Landlord now has or hereafter acquires, whether or not such claim, remedy
or right arises in equity or under contract, statute or common law, by any
payment made hereunder or otherwise, including, without limitation, the right to
take or receive from Tenant, directly or indirectly, in cash or other property
or by setoff or in any other manner, payment or security on account of such
claim or other rights. If, notwithstanding the foregoing provisions, any amount
shall be paid to Guarantor on account of any Guarantor's Conditional Rights and
either (i) such amount is paid to Guarantor at any time when Tenant's
Obligations shall not have been paid or performed in full, or (ii) regardless of
when such amount is paid to Guarantor, any payment made by Tenant to Landlord is
at any time determined to be a Preferential Payment, then such amount paid to
Guarantor shall be held in trust for the benefit of Landlord and shall forthwith
be paid to Landlord to be credited and applied upon Tenant's Obligations,
whether matured or unmatured, in such order as Landlord, in its sole and
absolute discretion, shall determine.

        (b) To the extent that any of the provisions of subsection (a) of the
above Section shall not be enforceable, Guarantor agrees that until such time as
Tenant's Obligations have been paid and performed in full and the period of time
has expired during which any payment made by Tenant or Guarantor to Landlord may
be determined to be a Preferential Payment, Guarantor's Conditional Rights to
the extent not validly waived shall be subordinate to Landlord's right to full
payment and performance of Tenant's Obligations, and Guarantor shall not enforce
Guarantor's Conditional Rights during such period.

        6. Costs and Expenses. If Guarantor fails to perform any of its
obligations under this Guaranty or if any dispute arises between the parties
hereto concerning the meaning or interpretation of any provision of this
Agreement, then the defaulting party or the party not prevailing in such
dispute, as the case may be, shall pay any and all costs and expenses incurred
by the other party on account of such default and/or in enforcing or
establishing its rights hereunder, including, without limitation, court costs
and reasonable attorneys' fees and disbursements. Any such attorneys' fees and
other expenses incurred by either party in




                                      C-3
<PAGE>

enforcing a judgment in its favor under this Agreement shall be recoverable
separately from and in addition to any other amount included in such judgment,
and such attorneys' fees obligation is intended to be severable from the other
provisions of this Agreement and to survive and not be merged into any such
judgment.

        7. Notices. Any notice, demand or request by Landlord to Guarantor shall
be in writing and shall be deemed to have been duly given or made if mailed by
certified or registered mail addressed to Guarantor at its address set forth
below its signature.

        8. Delay; Cumulative Remedies. No delay or failure by Landlord to
exercise any right or remedy against Tenant or Guarantor will be construed as a
waiver of that right or remedy. All remedies of Landlord against Tenant and
Guarantor are cumulative.

        9. Miscellaneous.

        (a) This Guaranty shall bind Guarantor, its successors and assigns, and
shall inure to the benefit of Landlord and its successors and assigns.

        (b) The invalidity or unenforceability of any one or more provisions of
this Guaranty will not affect any other provision.

        (c) This Guaranty and each and every term and provision thereof shall be
construed in accordance with the laws of the State of California.

        IN WITNESS WHEREOF, Guarantor has executed this instrument on the day
and year first above written.

                  GUARANTOR:    ____________________________________________,
                                a _______________________________ corporation


                                By: _________________________________________
                                Name: _______________________________________
                                Title: ______________________________________

                   ADDRESS:     _____________________________________________
                                _____________________________________________
                                _____________________________________________



                                      C-4
<PAGE>

                                   EXHIBIT D

                          COMMENCEMENT DATE MEMORANDUM

                 LANDLORD:    HMS GATEWAY OFFICE, L.P.

                   TENANT:    COULTER PHARMACEUTICAL, INC.

               LEASE DATE:    May 19, 2000

                 PREMISES:    Located at 630 Gateway Boulevard
                              South San Francisco, California

        Tenant hereby accepts the Premises as being in the condition required
under the Lease, with all Tenant Improvements completed (except for minor
punchlist items which Landlord agrees to complete).

        The Commencement Date of the Lease is hereby established as, __________,
______.

                   TENANT:    COULTER PHARMACEUTICAL, INC.,
                              a Delaware corporation

                              By: _________________________________________
                              Name: _______________________________________
                              Title: ______________________________________

Approved and Agreed:

LANDLORD:

HMS GATEWAY OFFICE, L.P.,
a Delaware limited liability company

By:  Hines Gateway Office, L.P.,
     General Partner

     By:  Hines Interests Limited Partnership,
          General Partner

          By:  Hines Holdings, Inc.,
               General Partner

               By: _________________________________________
               Name: _______________________________________
               Title: ______________________________________



                                      D-1
<PAGE>

                                    EXHIBIT E

                              RULES AND REGULATIONS

        This exhibit, entitled "Rules and Regulations," is and shall constitute
EXHIBIT E to the Lease Agreement, dated as of the Lease Date, by and between
Landlord and Tenant for the Premises. The terms and conditions of this Exhibit E
are hereby incorporated into and are made a part of the Lease. Capitalized terms
used, but not otherwise defined, in this EXHIBIT E have the meanings ascribed to
such terms in the Lease.

        1. Tenant shall not use any method of heating or air conditioning other
than that supplied by Landlord without the prior written consent of Landlord,
which consent shall not to be unreasonably withheld, conditioned or delayed.

        2. All window coverings installed by Tenant and visible firm the outside
of the building require the prior written approval of Landlord which approval
shall not to be unreasonably withheld, conditioned or delayed.

        3. Tenant shall not use, keep or permit to be used or kept any foul or
noxious gas or substance or any flammable or combustible materials on or around
the Premises, except to the extent that Tenant is permitted to use the same
under the terms of Paragraph 32 of the Lease.

        4. Tenant shall not alter any lock or install any new locks or bolts on
any door at the Premises without the prior written consent of Landlord, which
consent shall not to be unreasonably withheld, conditioned or delayed.

        5. Tenant shall not make any duplicate keys without the prior written
consent of Landlord, which consent shall not to be unreasonably withheld,
conditioned or delayed.

        6. Tenant shall park motor vehicles in parking areas designated by
Landlord except for loading and unloading. During those periods of loading and
unloading, Tenant shall not unreasonably interfere with traffic flow around the
Building or the Project and loading and unloading areas of other tenants.

        7. Tenant shall not disturb, solicit or canvas any tenant or other
occupant of the Building or Project and shall cooperate to prevent same.

        8. No person shall go on the roof without Landlord's permission.

        9. Business machines and mechanical equipment belonging to Tenant which
cause noise or vibration that may be transmitted to the structure of the
Building, to such a degree as to be objectionable to Landlord or other tenants,
shall be placed and maintained by Tenant, at Tenant's expense, on vibration
isolators or in noise-dampening housing or other devices sufficient to eliminate
noise or vibration.

        10. All goods, including material used to store goods, delivered to the
Premises of Tenant shall be immediately moved into the Premises and shall not be
left in parking or receiving areas overnight.




                                      E-1
<PAGE>

        11. Tenant is responsible for the storage and removal of all trash and
refuse. All such trash and refuse shall be contained in suitable receptacles
stored behind screened enclosures at locations approved by Landlord.

        12. Tenant shall not store or permit the storage or placement of goods
or merchandise in or around the common areas surrounding the Premises. No
displays or sales or merchandise shall be allowed in the parking lots or other
common areas.

        13. Tenant shall not permit any animals, including, but not limited to,
any household pets, to be brought or kept in or about the Premises, the
Building, the Project or any of the common areas which would violate applicable
Laws or constitute a nuisance to the Premises, the Building or the Project.




                                      E-2

<PAGE>
                                    EXHIBIT F

                   HAZARDOUS MATERIALS DISCLOSURE CERTIFICATE

        Your cooperation in this matter is appreciated. Initially, the
information provided by you in this Hazardous Materials Disclosure Certificate
is necessary for the Landlord to evaluate your proposed uses of the premises
(the "PREMISES") and to determine whether to enter into a lease agreement with
you as tenant. If a lease agreement is signed by you and the Landlord (the
"LEASE AGREEMENT"), on an annual basis in accordance with the provisions of
Paragraph 32 of the Lease Agreement, you are to provide an update to the
information initially provided by you in this certificate. Any questions
regarding this certificate should be directed to, and when completed, the
certificate should be delivered to:

Landlord:       HMS Gateway Office, L.P.
                c/o Hines Interests Limited Partnership
                651 Gateway Boulevard, Suite 1140
                South San Francisco, California 94080
                Attention: Catherine Fogelman
                Phone: (650) 794-1111

Name of (Prospective) Tenant: Coulter Pharmaceutical, Inc.

Mailing Address:
                ----------------------------------------------------------------

--------------------------------------------------------------------------------

Contact Person, Title and Telephone Number(s):
                                              ----------------------------------

Contact Person for Hazardous Waste Materials Management and Manifests and
Telephone Number(s):
                    ------------------------------------------------------------

--------------------------------------------------------------------------------

Address of (Prospective) Premises:
                                  ----------------------------------------------
Length of (Prospective) initial Term:
                                     -------------------------------------------


1.      GENERAL INFORMATION:

               Describe the proposed operations to take place in, on, or about
        the Premises, including, without limitation, principal products
        processed, manufactured or assembled, and services and activities to be
        provided or otherwise conducted. Existing tenants should describe any
        proposed changes to on-going operations.

--------------------------------------------------------------------------------

--------------------------------------------------------------------------------


                                      F-1


<PAGE>
2.      USE, STORAGE AND DISPOSAL OF HAZARDOUS MATERIALS

        2.1     Will any Hazardous Materials (as hereinafter defined) be used,
                generated, treated, stored or disposed of in, on or about the
                Premises? Existing tenants should describe any Hazardous
                Materials which continue to be used, generated, treated, stored
                or disposed of in, on or about the Premises.


<TABLE>
<S>                                        <C>         <C>
                Wastes                     Yes [ ]     No [ ]
                Chemical Products          Yes [ ]     No [ ]
                Other                      Yes [ ]     No [ ]
</TABLE>


                If Yes is marked, please explain:
                                                 -------------------------------

                ----------------------------------------------------------------

                ----------------------------------------------------------------

        2.2     If Yes is marked in Section 2.1, attach a list of any Hazardous
                Materials to be used, generated, treated, stored or disposed of
                in, on or about the Premises, including the applicable hazard
                class and an estimate of the quantities of such Hazardous
                Materials to be present on or about the Premises at any given
                time; estimated annual throughput; the proposed location(s) and
                method of storage (excluding nominal amounts of ordinary
                household cleaners and janitorial supplies which are not
                regulated by any Environmental Laws, as hereinafter defined);
                and the proposed location(s) and method(s) of treatment or
                disposal for each Hazardous Material, including the estimated
                frequency, and the proposed contractors or subcontractors.
                Existing tenants should attach a list setting forth the
                information requested above and such list should include actual
                data from ongoing operations and the identification of any
                variations in such information from the prior year's
                certificate.

3.      STORAGE TANKS AND SUMPS

        3.1     Is any above or below ground storage or treatment of gasoline,
                diesel, petroleum, or other Hazardous Materials in tanks or
                sumps proposed in, on or about the Premises? Existing tenants
                should describe any such actual or proposed activities.

                Yes [ ]   No [ ]

                If yes, please explain:
                                       -----------------------------------------

                ----------------------------------------------------------------

                ----------------------------------------------------------------


                                      F-2


<PAGE>
4.      WASTE MANAGEMENT

        4.1     Has your company been issued an EPA Hazardous Waste Generator
                I.D. Number? Existing tenants should describe any additional
                identification numbers issued since the previous certificate.

                Yes [ ]   No [ ]

        4.2     Has your company filed a biennial or quarterly reports as a
                hazardous waste generator? Existing tenants should describe any
                new reports filed.

                Yes [ ]   No [ ]

                If yes, attach a copy of the most recent report filed.

5.      WASTEWATER TREATMENT AND DISCHARGE

        5.1     Will your company discharge wastewater or other wastes to:

                [ ] storm drain?   [ ] sewer?
                [ ] surface water? [ ] no wastewater or other wastes discharged.

                Existing tenants should indicate any actual discharges. If so,
                describe the nature of any proposed or actual discharge(s).

                ----------------------------------------------------------------

                ----------------------------------------------------------------

        5.2     Will any such wastewater or waste be treated before discharge?

                Yes [ ]   No [ ]

                If yes, describe the type of treatment proposed to be conducted.
                Existing tenants should describe the actual treatment conducted.


                ----------------------------------------------------------------

                ----------------------------------------------------------------


                                      F-3


<PAGE>
6.      AIR DISCHARGES

        6.1     Do you plan for any air filtration systems or stacks to be used
                in your company's operations in, on or about the Premises that
                will discharge into the air; and will such air emissions be
                monitored? Existing tenants should indicate whether or not there
                are any such air filtration systems or stacks in use in, on or
                about the Premises which discharge into the air and whether such
                air emissions are being monitored.

                Yes [ ]   No [ ]

                If yes, please describe:
                                        ----------------------------------------

                ----------------------------------------------------------------

                ----------------------------------------------------------------


        6.2     Do you propose to operate any of the following types of
                equipment, or any other equipment requiring an air emissions
                permit? Existing tenants should specify any such equipment being
                operated in, on or about the Premises.

                [ ] Spray booth(s)      [ ] Incinerator(s)

                [ ] Dip tank(s)         [ ] Other (Please describe)

                [ ] Drying oven(s)      [ ] No Equipment Requiring Air Permits

                If yes, please describe:
                                        ----------------------------------------

                ----------------------------------------------------------------

                ----------------------------------------------------------------


        6.3     Please describe (and submit copies of with this Hazardous
                Materials Disclosure Certificate) any reports you have filed in
                the past [thirty-six] months with any governmental or
                quasi-governmental agencies or authorities related to air
                discharges or clean air requirements and any such reports which
                have been issued during such period by any such agencies or
                authorities with respect to you or your business operations.


                                      F-4


<PAGE>
7.      HAZARDOUS MATERIALS DISCLOSURES

        7.1     Has your company prepared or will it be required to prepare a
                Hazardous Materials management plan ("MANAGEMENT PLAN") or
                Hazardous Materials Business Plan and Inventory ("BUSINESS
                PLAN") pursuant to Fire Department or other governmental or
                regulatory agencies' requirements? Existing tenants should
                indicate whether or not a Management Plan is required and has
                been prepared.

                Yes [ ]   No [ ]

                If yes, attach a copy of the Management Plan or Business Plan.
                Existing tenants should attach a copy of any required updates to
                the Management Plan or Business Plan.

        7.2     Are any of the Hazardous Materials, and in particular chemicals,
                proposed to be used in your operations in, on or about the
                Premises listed or regulated under Proposition 65? Existing
                tenants should indicate whether or not there are any new
                Hazardous Materials being so used which are listed or regulated
                under Proposition 65.

                Yes [ ]   No [ ]

                If yes, please explain:
                                       -----------------------------------------

                ----------------------------------------------------------------

                ----------------------------------------------------------------

8.      ENFORCEMENT ACTIONS AND COMPLAINTS

        8.1     With respect to Hazardous Materials or Environmental Laws, has
                your company ever been subject to any agency enforcement
                actions, administrative orders, or consent decrees or has your
                company received requests for information, notice or demand
                letters, or any other inquiries regarding its operations?
                Existing tenants should indicate whether or not any such
                actions, orders or decrees have been, or are in the process of
                being, undertaken or if any such requests have been received.

                Yes [ ]   No [ ]

                If yes, describe the actions, orders or decrees and any
                continuing compliance obligations imposed as a result of these
                actions, orders or decrees and also describe any requests,
                notices or demands, and attach a copy of all such documents.
                Existing tenants should describe and attach a copy of any new
                actions, orders, decrees, requests, notices or demands not
                already delivered to Landlord pursuant to the provisions of
                Paragraph 32 of the Lease Agreement.


                ----------------------------------------------------------------

                ----------------------------------------------------------------

                ----------------------------------------------------------------


                                      F-5


<PAGE>
        8.2     Have there ever been, or are there now pending, any lawsuits
                against your company regarding any environmental or health and
                safety concerns?

                Yes [ ]   No [ ]

                If yes, describe any such lawsuits and attach copies of the
                complaint(s), cross-complaint(s), pleadings and other documents
                related thereto as requested by Landlord. Existing tenants
                should describe and attach a copy of any new complaint(s),
                cross-complaint(s), pleadings and other related documents not
                already delivered to Landlord pursuant to the provisions of
                Paragraph 32 of the Lease Agreement.


                ----------------------------------------------------------------

                ----------------------------------------------------------------

                ----------------------------------------------------------------


        8.3     Have there been any problems or complaints from adjacent
                tenants, owners or other neighbors at your company's current
                facility with regard to environmental or health and safety
                concerns? Existing tenants should indicate whether or not there
                have been any such problems or complaints from adjacent tenants,
                owners or other neighbors at, about or near the Premises and the
                current status of any such problems or complaints.

                Yes [ ]   No [ ]

                If yes, please describe. Existing tenants should describe any
                such problems or complaints not already disclosed to Landlord
                under the provisions of the signed Lease Agreement and the
                current status of any such problems or complaints.

                ----------------------------------------------------------------

                ----------------------------------------------------------------

                ----------------------------------------------------------------

9.      PERMITS AND LICENSES

        9.1     Attach copies of all permits and licenses issued to your company
                with respect to its proposed operations in, on or about the
                Premises, including, without limitation, any Hazardous Materials
                permits, wastewater discharge permits, air emissions permits,
                and use permits or approvals. Existing tenants should attach
                copies of any new permits and licenses as well as any renewals
                of permits or licenses previously issued.

        As used herein, "HAZARDOUS MATERIALS" shall mean and include any
substance that is or contains (a) any "hazardous substance" as now or hereafter
defined in Section 101(14) of the Comprehensive Environmental Response,
Compensation, and Liability Act of 1980, as amended ("CERCLA") (42 U.S.C.
Section 9601 et seq.) or any regulations promulgated under CERCLA; (b) any
"hazardous waste" as now or hereafter defined in the Resource Conservation and
Recovery Act, as amended ("RCRA") (42 U.S.C. Section 6901 et seq.) or any
regulations promulgated under RCRA;


                                      F-6


<PAGE>
(c) any substance now or hereafter regulated by the Toxic Substances Control
Act, as amended ("TSCA") (15 U.S.C. Section 2601 et seq.) or any regulations
promulgated under TSCA; (d) petroleum, petroleum by-products, gasoline, diesel
fuel, or other petroleum hydrocarbons; (e) asbestos and asbestos-containing
material, in any form, whether friable or non-friable; (f) polychlorinated
biphenyls; (g) lead and lead-containing materials; or (h) any additional
substance, material or waste (i) the presence of which on or about the Premises
(A) requires reporting, investigation or remediation under any Environmental
Laws (as hereinafter defined), (B) causes or threatens to cause a nuisance on
the Premises or any adjacent property or poses or threatens to pose a hazard to
the health or safety of persons on the Premises or any adjacent property, or (C)
which, if it emanated or migrated from the Premises, could constitute a
trespass, or (ii) which is now or is hereafter classified or considered to be
hazardous or toxic under any Environmental Laws; and "ENVIRONMENTAL LAWS" shall
mean and include (a) CERCLA, RCRA and TSCA; and (b) any other federal, state or
local laws, ordinances, statutes, codes, rules, regulations, orders or decrees
now or hereinafter in effect relating to (i) pollution, (ii) the protection or
regulation of human health, natural resources or the environment, (iii) the
treatment, storage or disposal of Hazardous Materials, or (iv) the emission,
discharge, release or threatened release of Hazardous Materials into the
environment.

        The undersigned hereby acknowledges and agrees that this Hazardous
Materials Disclosure Certificate is being delivered to Landlord in connection
with the evaluation of a Lease Agreement and, if such Lease Agreement is
executed, will be attached thereto as an exhibit. The undersigned further
acknowledges and agrees that if such Lease Agreement is executed, this Hazardous
Materials Disclosure Certificate will be updated from time to time in accordance
with Paragraph 32 of the Lease Agreement. The undersigned further acknowledges
and agrees that the Landlord and its partners, lenders and representatives may,
and will, rely upon the statements, representations, warranties, and
certifications made herein and the truthfulness thereof in entering into the
Lease Agreement and the continuance thereof throughout the term, and any
renewals thereof, of the Lease Agreement. I [print name] ______________, acting
with full authority to bind the (proposed) Tenant and on behalf of the
(proposed) Tenant, certify, represent and warrant that the information contained
in this certificate is true and correct.


(PROSPECTIVE) TENANT:

--------------------------------,

a
 --------------------------------


By:
   ------------------------------
Tide:
     ----------------------------
Date:
     ----------------------------


                                      F-7


<PAGE>
                                    EXHIBIT G

                              INITIAL WINDOW DATES


<TABLE>
<CAPTION>
                 CONDITION                            INITIAL WINDOW DATE
                 ---------                            -------------------
<S>                                                   <C>
Certificate from Landlord's Architect that the
foundation of the Building has been completed.         February 1, 2002

Certificate from Landlord's Architect that the
construction of the Building has progressed to a
"Water Tight Shell"                                    May 1, 2002
</TABLE>


                                      G-1


<PAGE>
                                    Exhibit H

                                TENANT'S PROPERTY

Laboratory related furniture and equipment including:

     benches and tables
     shelving
     sinks
     biosafety, laminar flow, and fume hoods
     cages/fencing
     DI water system
     emergency generator
     vacuum pumps
     compressed air
     nitrogen manifold

Office related furniture and equipment including:

     open office partitions
     telephone and network equipment
     reception desk
     lobby furniture
     lobby display cases
     appliances
     security system control panels, sensors, and CCTV equipment
     interior signage



INITIALS:

TENANT: /s/ W.G.H.
       ---------------

LANDLORD: /s/ J.C.B.
         -------------


                                      H-1


<PAGE>
                                    EXHIBIT I

                               MEMORANDUM OF LEASE

RECORDING REQUESTED BY AND
WHEN RECORDED RETURN TO:

Cooley Godward, LLP
3000 El Camino Real
Palo Alto, California 94306
Attention: Anna B. Pope, Esq.

                   (Space above this lire for Recorder's use)

                               MEMORANDUM OF LEASE

        THIS MEMORANDUM of LEASE is executed as of May 19, 2000, by and between
HMS GATEWAY OFFICE, L.P., a Delaware limited partnership ("LANDLORD"), and
COULTER PHARMACEUTICAL, INC., a Delaware corporation ("TENANT"). Landlord has
previously leased to Tenant a portion of that certain real property described on
EXHIBIT A attached hereto and incorporated herein by reference, together with
the building to be constructed thereon by Landlord to be known as 630 Gateway
Boulevard, South San Francisco, California, on the terms and conditions set
forth in that certain Lease between Landlord and Tenant dated as of May 19, 2000
(the "OFF RECORD LEASE"). The Off Record Lease has an estimated commencement
date of November 30, 2001 and an expiration date of November 13, 2010. Landlord
has also granted to Tenant (a) options to renew the term of the Lease for two
(2) additional periods of five (5) years each, and (b) a right of first offer
with respect to the premises being leased by Tenant, all on terms and conditions
of the Off Record Lease.


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<PAGE>
        IN WITNESS WHEREOF, the undersigned have executed this Memorandum of
Lease so that third parties might have notice of the lease by Landlord and
Tenant herein.

                   LANDLORD:  HMS GATEWAY OFFICE, L.P.,
                              a Delaware limited liability company

                              By:  Hines Gateway Office, L.P.,
                                   General Partner

                                   By:  Hines Interests Limited Partnership,
                                        General Partner

                                        By:  Hines Holdings, Inc.,
                                             General Partner

                                             By:
                                                ---------------------------
                                             Name:
                                                  -------------------------
                                             Title:
                                                   ------------------------


                   TENANT:    COULTER PHARMACEUTICAL, INC.,
                              a Delaware corporation

                              By:
                                 ---------------------------
                              Name:
                                   -------------------------
                              Title:
                                    ------------------------


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