# Patent

## Title
N-ureidoheterocycloalkyl-piperidines as modulators of chemokine receptor activity

## Abstract

The present application describes modulators of CCR3 of formula (I): 




or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.

## Background
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a divisional of U.S. application Ser. No. 09/895,138, filed Jun. 29, 2001, now U.S. Pat. No. 6,627,629, which claims the priority benefit of U.S. application No. 60/215,215, filed on Jun. 30, 2000.


FIELD OF THE INVENTION
This invention relates generally to modulators of chemokine receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and prevention of inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis.
BACKGROUND OF THE INVENTION
Chemokines are chemotactic cytokines, of molecular weight 6-15 kDa, that are released by a wide variety of cells to attract and activate, among other cell types, macrophages, T and B lymphocytes, eosinophils, basophils and neutrophils (reviewed in Luster, New Eng. J. Med., 338, 436-445 (1998) and Rollins, Blood, 90, 909-928 (1997)). There are two major classes of chemokines, CXC and CC, depending on whether the first two cysteines in the amino acid sequence are separated by a single amino acid (CXC) or are adjacent (CC). The CXC chemokines, such as interleukin-8 (IL-8), neutrophil-activating protein-2 (NAP-2) and melanoma growth stimulatory activity protein (MGSA) are chemotactic primarily for neutrophils and T lymphocytes, whereas the CC chemokines, such as RANTES, MIP-1α, MIP-1β, the monocyte chemotactic proteins (MCP-1, MCP-2, MCP-3, MCP-4, and MCP-5) and the eotaxins (-1, -2, and -3) are chemotactic for, among other cell types, macrophages, T lymphocytes, eosinophils, dendritic cells, and basophils. There also exist the chemokines lymphotactin-1, lymphotactin-2 (both C chemokines), and fractalkine (a CXXXC chemokine) that do not fall into either of the major chemokine subfamilies.
The chemokines bind to specific cell-surface receptors belonging to the family of G-protein-coupled seven-transmembrane-domain proteins (reviewed in Horuk, Trends Pharm. Sci., 15, 159-165 (1994)) which are termed “chemokine receptors.” On binding their cognate ligands, chemokine receptors transduce an intracellular signal through the

    
    
        associated trimeric G proteins, resulting in, among other responses, a rapid increase in intracellular calcium concentration, changes in cell shape, increased expression of cellular adhesion molecules, degranulation, and promotion of cell migration. There are at least ten human chemokine receptors that bind or respond to CC chemokines with the following characteristic patterns: CCR-1 (or “CKR-1” or “CC-CKR-1”) [MIP-1α, MCP-3, MCP-4, RANTES] (Ben-Barruch, et al., Cell, 72, 415-425 (1993), Luster, New Eng. J. Med., 338, 436-445 (1998)); CCR-2A and CCR-2B (or “CKR-2A”/“CKR-2B” or “CC-CKR-2A”/“CC-CKR-2B”) [MCP-1, MCP-2, MCP-3, MCP-4, MCP-5] (Charo et al., Proc. Natl. Acad. Sci. USA, 91, 2752-2756 (1994), Luster, New Eng. J. Med., 338, 436-445 (1998)); CCR-3 (or “CKR-3” or “CC-CKR-3”) [eotaxin-1, eotaxin-2, RANTES, MCP-3, MCP-4] (Combadiere, et al., J. Biol. Chem., 270, 16491-16494 (1995), Luster, New Eng. J. Med., 338, 436-445 (1998)); CCR-4 (or “CKR-4” or “CC-CKR-4”) [TARC, MIP-1α, RANTES, MCP-1] (Power et al., J. Biol. Chem., 270, 19495-19500 (1995), Luster, New Eng. J. Med., 338, 436-445 (1998)); CCR-5 (or “CKR-5” OR “CC-CKR-5”) [MIP-1α, RANTES, MIP-1β] (Sanson, et al., Biochemistry, 35, 3362-3367 (1996)); CCR-6 (or “CKR-6” or “CC-CKR-6”) [LARC] (Baba et al., J. Biol. Chem., 272, 14893-14898 (1997)); CCR-7 (or “CKR-7” or “CC-CKR-7”) [ELC] (Yoshie et al., J. Leukoc. Biol. 62, 634-644 (1997)); CCR-8 (or “CKR-8” or “CC-CKR-8”) [I-309, TARC, MIP-1β] (Napolitano et al., J. Immunol., 157, 2759-2763 (1996), Bernardini et al., Eur. J. Immunol., 28, 582-588 (1998)); and CCR-10 (or “CKR-10” or “CC-CKR-10”) [MCP-1, MCP-3] (Bonini et al, DNA and Cell Biol., 16, 1249-1256 (1997)).
    
    


In addition to the mammalian chemokine receptors, mammalian cytomegaloviruses, herpesviruses and poxviruses have been shown to express, in infected cells, proteins with the binding properties of chemokine receptors (reviewed by Wells and Schwartz, Curr. Opin. Biotech., 8, 741-748 (1997)). Human CC chemokines, such as RANTES and MCP-3, can cause rapid mobilization of calcium via these virally encoded receptors. Receptor expression may be permissive for infection by allowing for the subversion of normal immune system surveillance and response to infection. Additionally, human chemokine receptors, such as CXCR4, CCR2, CCR3, CCR5 and CCR8, can act as co-receptors for the infection of mammalian cells by microbes as with, for example, the human immunodeficiency viruses (HIV).
Chemokine receptors have been implicated as being important mediators of inflammatory, infectious, and immunoregulatory disorders and diseases, including asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. For example, the chemokine receptor CCR-3 plays a pivotal role in attracting eosinophils to sites of allergic inflammation and in subsequently activating these cells. The chemokine ligands for CCR-3 induce a rapid increase in intracellular calcium concentration, increased expression of cellular adhesion molecules, cellular degranulation, and the promotion of eosinophil migration. Accordingly, agents which modulate chemokine receptors would be useful in such disorders and diseases. In addition, agents which modulate chemokine receptors would also be useful in infectious diseases such as by blocking infection of CCR3 expressing cells by HIV or in preventing the manipulation of immune cellular responses by viruses such as cytomegaloviruses.
A substantial body of art has accumulated over the past several decades with respect to substituted piperidines and pyrrolidines. These compounds have implicated in the treatment of a variety of disorders.
WO 98/25604 describes spiro-substituted azacycles which are useful as modulators of chemokine receptors: 




wherein R1 is C1-6 alkyl, optionally substituted with functional groups such as —NR6CONHR7, wherein R6 and R7 may be phenyl further substituted with hydroxy, alkyl, cyano, halo and haloalkyl. Such spiro compounds are not considered part of the present invention.

WO 95/13069 is directed to certain piperidine, pyrrolidine, and hexahydro-1H-azepine compounds of general formula: 




wherein A may be substituted alkyl or Z-substituted alkyl, with Z=NR6a or O. Compounds of this type are claimed to promote the release of growth hormone in humans and animals.

WO 93/06108 discloses pyrrolobenzoxazine derivatives as 5-hydroxytryptamine (5-HT) agonists and antagonists: 




wherein A is lower alkylene and R4 may be phenyl optionally substituted with halogen.

U.S. Pat. No. 5,668,151 discloses Neuropeptide Y (NPY) antagonists comprising 1,4-dihydropyridines with a piperidinyl or tetrahydropyridinyl-containing moiety attached to the 3-position of the 4-phenyl ring: 




wherein B may be NH, NR1, O, or a bond, and R7 may be substituted phenyl, benzyl, phenethyl and the like.

Patent publication EP 0 903 349 A2 discloses CCR-3 receptor antagonists comprising cyclic amines of the following structure: 




wherein T and U may be both nitrogen or one of T and U is nitrogen and the other is carbon and E may be —NR6CONR5— and others.

These reference compounds are readily distinguished structurally by either the nature of the urea functionality, the attachment chain, or the possible substitution of the present invention. The prior art does not disclose nor suggest the unique combination of structural fragments which embody these novel piperidine amides as having activity toward the chemokine receptors.
SUMMARY OF THE INVENTION
Accordingly, one object of the present invention is to provide novel agonists or antagonists of CCR-3, or pharmaceutically acceptable salts or prodrugs thereof.
It is another object of the present invention to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt or prodrug form thereof.
It is another object of the present invention to provide a method for treating inflammatory diseases and allergic disorders comprising administering to a host in need of such treatment a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt or prodrug form thereof.
It is another object of the present invention to provide novel N-ureidoheterocycloalkyl-piperidines for use in therapy.
It is another object of the present invention to provide the use of novel N-ureidoheterocycloalkyl-piperidines for the manufacture of a medicament for the treatment of allergic disorders.
These and other objects, which will become apparent during the following detailed description, have been achieved by the inventors' discovery that compounds of formula (I): 




or stereoisomers or pharmaceutically acceptable salts thereof, wherein E, Z, M, J, K, L, Q, R1, R2, R3, and R4 are defined below, are effective modulators of chemokine activity.



DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS
[1] Thus, in a first embodiment, the present invention provides novel compounds of formula (I): 




or stereoisomers or pharmaceutically acceptable salts thereof, wherein:


    M is absent or selected from CH2, CHR5, CHR13, CR13R13, and CR5R13;
    Q is selected from CH2, CHR5, CHR13, CR13R13, and CR5R13;
    J and K are independently selected from CH2, CHR5, CHR6, CR6R6 and CR5R6;
    L is selected from CHR5 and CR5R6;
    with the proviso:
    
        when M is absent, J is selected from CH2, CHR5, CHR13, and CR5R13;
    
    
    Z is selected from O, S, NR1a, C(CN)2, CH(NO2), and CHCN;
    R1a is selected from H, C1-6 alkyl, C3-6 cycloalkyl, CONR1bR1b, OR1b, CN, NO2, and (CH2)wphenyl;
    R1b is independently selected from H, C1-3 alkyl, C3-6 cycloalkyl, and phenyl; 




    G is selected from a bond, C═O, and SO2;
    Ring B is a 5, 6, or 7 membered saturated heterocyclic ring wherein the heterocycle ring includes —NR9—, —O—, —S(O)p—, —NR9dC(O)—, —C(O)NR9d—, —C(O)O—, —OC(O)—, —NR9dC(O)NR9d, —NR9dC(O)O—, —NR9dS(O)2—, —S(O)2NR9d, or —OC(O)NR9d—, the heterocycle ring being optionally substituted by 0-2 R8;
    R1 and R2 are independently selected from H, C1-8 alkyl, C3-8 alkenyl, C3-8 alkynyl, and (CH2)rC3-6 cycloalkyl;
    R3 is selected from methyl substituted with 0-1 R10, C2-8 alkyl substituted with 0-3 R7, C3-8 alkenyl substituted with 0-3 R7, C3-8 alkynyl substituted with 0-3 R7, C2 fluoroalkyl, C3-8 haloalkyl, a (CR3′R3′′)r—C3-10 carbocyclic residue substituted with 0-5 R15 and a (CR3′R3′′)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R15;
    R3′ and R3′′, at each occurrence, are selected from H, C1-6 alkyl, (CH2)rC3-6 cycloalkyl, and phenyl;
    R4 is absent, taken with the nitrogen to which it is attached to form an N-oxide, or selected from C1-8 alkyl, C3-8 alkenyl, C3-8 alkynyl, (CH2)rC3-6 cycloalkyl, (CH2)qC(O)R4b, (CH2)qC(O)NR4aR4a′, (CH2)qC(O)OR4b, and a (CH2)r—C3-10 carbocyclic residue substituted with 0-3 R4c;
    R4a and R4a′, at each occurrence, are selected from H, C1-6 alkyl, (CH2)rC3-6 cycloalkyl, and phenyl;
    R4b, at each occurrence, is selected from C1-6 alkyl, C3-8 alkenyl, (CH2)rC3-6 cycloalkyl, C3-8 alkynyl, and phenyl;
    R4c, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)rOH, (CH2)rSC1-5 alkyl, (CH2)rNR4aR4a′, and (CH2)rphenyl;
    R5 is selected from a (CR5′R5′′)t—C3-10 carbocyclic residue substituted with 0-5 R16 and a (CR5′R5′′)t-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R16;
    R5′ and R5′′, at each occurrence, are selected from H, C1-6 alkyl, (CH2)rC3-6 cycloalkyl, and phenyl;
    R6, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, (CF2)rCF3, CN, (CH2)rNR6aR6a′, (CH2)rOH, (CH2)rOR6b, (CH2)rSH, (CH2)rSR6b, (CH2)rC(O)OH, (CH2)rC(O)R6b, (CH2)rC(O)NR6aR6a′, (CH2)rNR6dC(O)R6a, (CH2)rC(O)OR6b, (CH2)rOC(O)R6b, (CH2)rS(O)pR6b, (CH2)rS(O)2NR6aR6a′, (CH2)rNR6dS(O)2R6b, and (CH2)tphenyl substituted with 0-3 R6c;
    R6a and R6a′, at each occurrence, are selected from H, C1-6 alkyl, C3-6 cycloalkyl, and phenyl substituted with 0-3 R6c;
    R6b, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl, and phenyl substituted with 0-3 R6c;
    R6c, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)rOH, (CH2)rSC1-5 alkyl, and (CH2)rNR6dR6d;
    R6d, at each occurrence, is selected from H, C1-6 alkyl, and C3-6 cycloalkyl;
    with the proviso that when any of J or K is CR6R6 and R6 is cyano, or bonded to the carbon to which it is attached through a heteroatom, the other R6 is not cyano, or bonded to the carbon to which it is attached through a heteroatom;
    R7 is selected from NO2, CN, NR7aR7a′, OH, OR7d, C(O)H, C(O)OH, C(O)R7b, C(O)NR7aR7a′, NR7fC(O)OR7d, OC(O)NR7aR7a′, NR7fC(O)R7b, NR7fC(O)NR7fR7f, C(O)OR7d, OC(O)R7b, C(═NR7f)NR7aR7a′, NHC(═NR7f)NR7fR7f, S(O)pR7b, S(O)2NR7aR7a′, NR7fS(O)2R7b, C1-6 haloalkyl;
    R7a and R7a′, at each occurrence, are selected from H, C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)r—C3-10 carbocyclic residue substituted with 0-5 R7e, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R7e;
    alternatively, R7a and R7a′, along with the N to which they are attached, join to form a 5-6 membered heterocyclic system containing 1-2 heteroatoms selected from NR7h, O, and S and optionally fused with a benzene ring or a 6-membered aromatic heterocycle;
    R7b, at each occurrence, is selected from H, C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)r—C3-6 carbocyclic residue substituted with 0-3 R7e, and (CH2)r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R7e;
    R7d, at each occurrence, is selected from C3-8 alkenyl, C3-8 alkynyl, methyl, CF3, C2-6 alkyl substituted with 0-3 R7e, a (CH2)r—C3-10 carbocyclic residue substituted with 0-3 R7e, and a (CH2)r5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R7e;
    R7e, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, C(O)C1-16 alkyl, C(O)OC1-6 alkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, OH, SH, (CH2)rSC1-5 alkyl, (CH2)rNR7fR7f, (CH2)rphenyl, and a heterocycle substituted with 0-1 R7g, wherein the heterocycle is selected from imidazole, thiazole, oxazole, pyrazole, 1,2,4-triazole, 1,2,3-triazole, isoxazole, and tetrazole;
    R7f, at each occurrence, is selected from H, C1-6 alkyl, C3-6 cycloalkyl, and phenyl;
    R7g is selected from methyl, ethyl, acetyl, and CF3;
    R7h is selected from H, C1-6 alkyl, C3-6 cycloalkyl, (CH2)rphenyl, C(O)R7f, C(O)OR7i, and SO2R7i;
    R7i, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl;
    R8 is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, C1-6 haloalkyl, a (CH2)r—C3-10 carbocyclic residue substituted with 0-3 R8c, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R8c;
    R8a, at each occurrence, are selected from H, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, a (CH2)r—C3-10 carbocyclic residue substituted with 0-5 R8e, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R8e;
    R8b, at each occurrence, is selected from C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)r—C3-6 carbocyclic residue substituted with 0-2 R8e, and a (CH2)r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R8e;
    R8c, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, Cl, Br, I, F, (CF2)rCF3, NO2, CN, (CH2)rNR8fR8f, (CH2)rOH, (CH2)rOC1-4 alkyl, (CH2)rSC1-4 alkyl, (CH2)rC(O)OH, (CH2)rC(O)R8a, (CH2)rC(O)NR8fR8f, (CH2)rNR8fC(O)R8a, (CH2)rC(O)OC1-4 alkyl, (CH2)rOC(O)R8b, (CH2)rS(O)pR8b , (CH2)rS(O)2NR8fR8f, (CH2)rNR8fS(O)2R8b, and (CH2)rphenyl substituted with 0-3 R8e;
    R8e, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)rOH, (CH2)rSH, (CH2)rSC1-5 alkyl, (CH2)rNR8fR8f, and (CH2)rphenyl;
    R8f, at each occurrence, is selected from H, C1-6 alkyl, and C3-6 cycloalkyl;
    R9 is selected from H, CH3, C2-6 alkyl substituted with 0-3 R9a, C3-8 alkenyl, C3-8 alkynyl, C1-6 haloalkyl, (CHR′)rC(O)C1-6 alkyl substituted with 0-3 R9j, (CHR′)rC(O)OC1-6 alkyl substituted with 0-3 R9b, (CHR′)rC(O)NR9dR9d′′, (CHR′)rS(O)2C1-6 alkyl, S(O)2C1-6 haloalkyl, (CHR′)rS(O)2NR9dR9d, R9′, (CHR′)rC(O)R9′, (CHR′)rC(O)NR9dR9′, (CHR′)rS(O)2R9′, and (CHR′)rS(O)2NR9dR9′;
    R9′, at each occurrence, is independently selected from (CHR′)rC3-6 cycloalkyl substituted with 0-3 R9e, (CHR′)rphenyl substituted with 0-3 R9c, (CHR′)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R9c,
    R9a, at each occurrence, is selected from CN, NO2, OC1-5 alkyl, CF3, OH, OC1-5 alkyl, OC(O)C1-5 alkyl, SC1-5 alkyl, S(O)pC1-5 alkyl, and NR9dR9d′;
    R9b, at each occurrence, is selected from C3-6 cycloalkyl, CN, (CF2)rCF3, (CH2)qOC1-5 alkyl, (CH2)qOH, (CH2)qSC1-15 alkyl, (CH2)rS(O)pC1-5 alkyl, and (CH2)qNR9dR9d′;
    R9c, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CHR′)rC(O)C1-5 alkyl, (CHR′)rC(O)OC1-5 alkyl, (CHR′)rC(O)NR9dR9d′, (CH2)rOH, (CH2)rSC1-5 alkyl, (CH2)rS(O)pC1-5 alkyl, and (CH2)rNR9dR9d′;
    provided that if R9c is attached to a carbon attached to the nitrogen on Ring B, then R9c is selected from (CH2)qOH, (CH2)qOC1-5 alkyl, (CH2)qSC1-15 alkyl, (CH2)qS(O)qC1-15 alkyl, and (CH2)qNR9dR9d′;
    R9d and R9d′, at each occurrence, are independently selected from H, C1-6 alkyl, C3-6 cycloalkyl, and phenyl;
    alternatively, R9d and R9d′, along with the N to which they are attached, join to form a 5-6 membered heterocyclic system containing 1-2 heteroatoms selected from NR9h , O, and S and optionally fused with a benzene ring or a 6-membered aromatic heterocycle;
    R9e, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CHR′)rC(O)OC1-5 alkyl, (CHR′)rC(O)NR9dR9d′, (CH2)rOH, (CH2)rSC1-5 alkyl, (CH2)rS(O)pC1-5 alkyl, and (CH2)rNR9dR9d′, or alternatively, two R9e on the same carbon atom form ═O;
    R9h is selected from H, C1-6 alkyl, C3-6 cycloalkyl, (CH2)rphenyl, C(O)R9f, C(O)OR9i, and SO2R9i;
    R9i, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl;
    R9j, at each occurrence, is selected from C3-6 cycloalkyl, CN, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)rOH, (CH2)rSC1-5 alkyl, (CH2)rS(O)pC1-5 alkyl, and (CH2)rNR9dR9d′;
    R10 is selected from C(O)H, C(O)OH, C(O)R10b, C(O)NR10aR10a′, C(O)OR10d, C(═NR10f)NR10aR10a′, S(O)R10b, S(O)2R10b, S(O)2NR10aR10a′;
    R10a and R10a′, at each occurrence, are selected from H, C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)r—C3-10 carbocyclic residue substituted with 0-5 R10e, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R10e;
    alternatively, R10a and R10a′, along with the N to which they are attached, join to form a 5-6 membered heterocyclic system containing 1-2 heteroatoms selected from NR10h, O, and S and optionally fused with a benzene ring or a 6-membered aromatic heterocycle;
    R10b, at each occurrence, is selected from C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)r—C3-6 carbocyclic residue substituted with 0-3 R10e, and (CH2)r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R10e;
    R10d, at each occurrence, is selected from C3-8 alkenyl, C3-8 alkynyl, methyl, CF3, C2-6 alkyl substituted with 0-3 R10e, a (CH2)r—C3-10 carbocyclic residue substituted with 0-3 R10e, and a (CH2)r5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R10e;
    R10e, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, C(O)C1-16 alkyl, C(O)OC1-6 alkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, OH, SH, (CH2)rSC1-5 alkyl, (CH2)rNR10fR10f, (CH2)rphenyl, and a heterocycle substituted with 0-1 R10g, wherein the heterocycle is selected from imidazole, thiazole, oxazole, pyrazole, 1,2,4-triazole, 1,2,3-triazole, isoxazole, and tetrazole;
    R10f, at each occurrence, is selected from H, C1-6 alkyl, C3-6 cycloalkyl, and phenyl;
    R10g is selected from methyl, ethyl, acetyl, and CF3;
    R10h is selected from H, C1-6 alkyl, C3-6 cycloalkyl, (CH2)rphenyl, C(O)R10f, C(O)OR10i, and SO2R10i;
    R10i, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl;
    R13, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-6 cycloalkyl, (CF2)wCF3, (CH2)qNR13aR13a′, (CH2)qOH, (CH2)qOR13b, (CH2)qSH, (CH2)qSR13b, (CH2)wC(O)OH, (CH2)wC(O)R13b, (CH2)wC(O)NR13aR13a′, (CH2)qNR13dC(O)R13a, (CH2)wC(O)OR13b, (CH2)qOC(O)R13b, (CH2)wS(O)pR13b, (CH2)wS(O)2NR13aR13a′(CH2)qNR13dS(O)2R13b, and (CH2)w-phenyl substituted with 0-3 R13c;
    R13a and R13a′, at each occurrence, are selected from H, C1-6 alkyl, C3-6 cycloalkyl, and phenyl substituted with 0-3 R13c;
    R13b, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl, and phenyl substituted with 0-3 R13c;
    R13c, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)rOH, (CH2)rSC1-5 alkyl, and (CH2)rNR13dR13d;
    R13d, at each occurrence, is selected from H, C1-6 alkyl, and C3-6 cycloalkyl;
    R15, at each occurrence, is selected from ═O, C1-8 alkyl, (CH2)rC3-6 cycloalkyl, Cl, Br, I, F, NO2, CN, (CHR′)rNR15aR15a′, (CHR′)rOH, (CHR′)rO(CHR′)rR15d, (CHR′)rSH, (CHR′)rC(O)H, (CHR′)rC(O)OH, (CHR′)rC(O) (CHR′)rR15b, (CHR′)rC(O)NR15aR15a′, (CHR′)rNR15fC(O)O(CHR′)rR15d, (CHR′)rOC(O)NR15aR15a′, (CHR′)rNR15fC(O)(CHR′)rR15b, (CHR′)rNR15fC(O)NR15fR15f, (CHR′)rC(O)O(CHR′)rR15d, (CHR′)rOC(O)(CHR′)rR15b, (CHR′)rC(═NR15f)NR15aR15a′, (CHR′)rNHC(═NR15f)NR15fR15f, (CHR′)rS(O)p(CHR′)rR15b, (CHR′)rS(O)2NR15aR15a′, (CHR′)rNR15fS(O)2(CHR′)rR15b, C1-6 haloalkyl, C2-8 alkenyl substituted with 0-3 R′, C2-8 alkynyl substituted with 0-3 R′, (CHR′)rphenyl substituted with 0-3 R15e, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R15e;
    R′, at each occurrence, is independently selected from H, C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, (CH2)rC3-6 cycloalkyl, and (CH2)rphenyl substituted with R15e;
    R15a and R15a′, at each occurrence, are selected from H, C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)r—C3-10 carbocyclic residue substituted with 0-5 R15e, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R15e;
    alternatively, R15a and R15a′, along with the N to which they are attached, join to form a 5-6 membered heterocyclic system containing 1-2 heteroatoms selected from NR15h, O, and S and optionally fused with a benzene ring or a 6-membered aromatic heterocycle;
    R15b, at each occurrence, is selected from C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)r—C3-6 carbocyclic residue substituted with 0-3 R15e, and (CH2)r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R15e;
    R15d, at each occurrence, is selected from C3-8 alkenyl, C3-8 alkynyl, methyl, CF3, C2-6 alkyl substituted with 0-3 R15e, a (CH2)r—C3-10 carbocyclic residue substituted with 0-3 R15e, and a (CH2)r5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R15e;
    R15e, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, C(O)C1-6 alkyl, C(O)OC1-6 alkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, OH, SH, (CH2)rSC1-5 alkyl, (CH2)rNR15fR15f, (CH2)rphenyl, and a heterocycle substituted with 0-1 R15 g, wherein the heterocycle is selected from imidazole, thiazole, oxazole, pyrazole, 1,2,4-triazole, 1,2,3-triazole, isoxazole, and tetrazole;
    R15f, at each occurrence, is selected from H, C1-6 alkyl, C3-6 cycloalkyl, and phenyl;
    R15g is selected from methyl, ethyl, acetyl, and CF3;
    R15h is selected from H, C1-6 alkyl, C3-6 cycloalkyl, (CH2)rphenyl, C(O)R15f, C(O)OR15i, and SO2R15i;
    R15i, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl;
    R16, at each occurrence, is selected from C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, Cl, Br, I, F, NO2, CN, (CHR′)rNR16aR16a′, (CHR′)rOH, (CHR′)rO(CHR′)rR16d, (CHR′)rSH, (CHR′)rC(O)H, (CHR′)rC(O)OH, (CHR′)rC(O) (CHR′)rR16b, (CHR′)rC(O)NR16aR16a′, (CHR′)rNR16fC(O)(CHR′)rR16b, (CHR′)rC(O)O(CHR′)rR16d, (CHR′)rOC(O)(CHR′)rR16b, (CHR′)rC(═NR16f)NR16aR16a′, (CHR′)rNHC(═NR16f)NR16fR16f, (CHR′)rS(O)p(CHR′)rR16b, (CHR′)rS(O)2NR16aR16a′, (CHR′)rNR16fS(O)2(CHR′)rR16b, C1-6 haloalkyl, C2-8 alkenyl substituted with 0-3 R′, C2-8 alkynyl substituted with 0-3 R′, and (CHR′)rphenyl substituted with 0-3 R16e;
    R16a and R16a′, at each occurrence, are selected from H, C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)r—C3-10 carbocyclic residue substituted with 0-5 R16e, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R16e;
    alternatively, R16a and R16a′, along with the N to which they are attached, join to form a 5-6 membered heterocyclic system containing 1-2 heteroatoms selected from NR16h, O, and S and optionally fused with a benzene ring or a 6-membered aromatic heterocycle;
    R16b, at each occurrence, is selected from C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)rC3-6 carbocyclic residue substituted with 0-3 R16e, and a (CH2)r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R16e;
    R16d, at each occurrence, is selected from C3-8 alkenyl, C3-8 alkynyl, C1-6 alkyl substituted with 0-3 R16e, a (CH2)r—C3-10 carbocyclic residue substituted with 0-3 R16e, and a (CH2)r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R16e;
    R16e, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, OH, SH, (CH2)rSC1-5 alkyl, (CH2)rNR16fR16f, and (CH2)rphenyl;
    R16f, at each occurrence, is selected from H, C1-5 alkyl, and C3-6 cycloalkyl, and phenyl;
    R16h is selected from H, C1-6 alkyl, C3-6 cycloalkyl, (CH2)rphenyl, C(O)R16f, C(O)OR16i, and SO2R16i;
    R16i, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl;
    m, at each occurrence, is independently selected from 0, 1, and 2;
    t, at each occurrence, is independently selected from 1 and 2;
    w, at each occurrence, is independently selected from 0 and 1;
    r, at each occurrence, is independently selected from 0, 1, 2, 3, 4, and 5;
    q, at each occurrence, is independently selected from 1, 2, 3, 4, and 5; and
    p, at each occurrence, is independently selected from 0, 1, and 2.


[2] In another embodiment, the present invention provides novel compounds of formula (I), wherein:

    R4 is absent, taken with the nitrogen to which it is attached to form an N-oxide, or selected from C1-8 alkyl, (CH2)rC3-6 cycloalkyl, and (CH2)r-phenyl substituted with 0-3 R4c;
    R4c, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)rOH, (CH2)rSC1-15 alkyl, (CH2)rNR4aR4a′, and (CH2)rphenyl;
    R1 and R2 are independently selected from H and C1-4 alkyl;
    R6, at each occurrence, is selected from C1-4 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, (CF2)rCF3, CN, (CH2)rOH, (CH2)rOR6b, (CH2)rC(O)R6b, (CH2)rC(O)NR6aR6a′, (CH2)rNR6dC(O)R6a, and (CH2)tphenyl substituted with 0-3 R6c;
    R6a and R6a′, at each occurrence, are selected from H, C1-6 alkyl, C3-6 cycloalkyl, and phenyl substituted with 0-3 R6c;
    R6b, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl, and phenyl substituted with 0-3 R6c;
    R6c, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)rOH, (CH2)rSC1-5 alkyl, and (CH2)rNR6dR6d;
    R6d, at each occurrence, is selected from H, C1-6 alkyl, and C3-6 cycloalkyl;
    R13, at each occurrence, is selected from C1-4 alkyl, C3-6 cycloalkyl, (CH2)NR13aR13a′, (CH2)OH, (CH2)OR13b, (CH2)wC(O)R13b, (CH2)wC(O)NR13aR13a′, (CH2)NR13dC(O)R13a, (CH2)wS(O)2NR13aR13a′, (CH2)NR13dS(O)2R13b, and (CH2)w-phenyl substituted with 0-3 R13c;
    R13a and R13a′, at each occurrence, are selected from H, C1-6 alkyl, C3-6 cycloalkyl, and phenyl substituted with 0-3 R13c;
    R13b, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl, and phenyl substituted with 0-3 R13c;
    R13c, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)rOH, and (CH2)rNR13dR13d;
    R13d, at each occurrence, is selected from H, C1-6 alkyl, and C3-6 cycloalkyl;
    q is selected from 1, 2, and 3; and
    r is selected from 0, 1, 2, and 3.


[3] In another embodiment, the present invention provides novel compounds of formula (I), wherein:

    R3 is selected from a methyl substituted with 0-1 R10, C2-8 alkyl substituted with 0-3 R7, a (CR3′H)r-carbocyclic residue substituted with 0-5 R15, wherein the carbocyclic residue is selected from phenyl, C3-6 cycloalkyl, naphthyl, and adamantyl; and a (CR3′H)r-heterocyclic system substituted with 0-3 R15, wherein the heterocyclic system is selected from pyridinyl, thiophenyl, furanyl, indazolyl, benzothiazolyl, benzimidazolyl, benzothiophenyl, benzofuranyl, benzoxazolyl, benzisoxazolyl, quinolinyl, isoquinolinyl, imidazolyl, indazolyl, isoxazolinyl, morpholinyl, pyrrolidinyl, tetrahydropyranyl, tetrahydrofuranyl, indolyl, indolinyl, isoindolyl, isothiadiazolyl, isoxazolyl, piperidinyl, pyrrazolyl, 1,2,4-triazolyl, 1,2,3-triazolyl, tetrazolyl, thiadiazolyl, thiazolyl, oxazolyl, pyrazinyl, and pyrimidinyl; and
    R5 is selected from (CR5′H)t-phenyl substituted with 0-5 R16; and a (CR5′H)t-heterocyclic system substituted with 0-3 R16, wherein the heterocyclic system is selected from pyridinyl, thiophenyl, furanyl, indazolyl, benzothiazolyl, benzimidazolyl, benzothiophenyl, benzofuranyl, benzoxazolyl, benzisoxazolyl, quinolinyl, isoquinolinyl, imidazolyl, indolyl, indolinyl, isoindolyl, isothiadiazolyl, isoxazolyl, piperidinyl, pyrrazolyl, 1,2,4-triazolyl, 1,2,3-triazolyl, tetrazolyl, thiadiazolyl, thiazolyl, oxazolyl, pyrazinyl, and pyrimidinyl.


[4] In another embodiment, the present invention provides novel compounds of formula (I), wherein:

    Ring B is a 5 or 6 membered heterocycle ring wherein the heterocycle ring includes —NR9—, —O—, —S(O)p—, —NR9dC(O)—, —C(O)NR9d—, —C(O)O—, —OC(O)—, —NR9dC(O)NR9d, —NR9dC(O)O—, —OC(O)NR9d—, —NR9dS(O)2—, or —S(O)2NR9d, the heterocycle ring being optionally substituted by 0-2 R8;
    R9 is selected from H, CH3, C2-6 alkyl substituted with 0-3 R9a, C3-8 alkenyl, C3-8 alkynyl, C1-3 haloalkyl, (CH2)rC(O)C1-6 alkyl substituted with 0-2 R9j, (CH2)rC(O)OC1-6 alkyl substituted with 0-3 R9b, (CH2)rC(O)NR9dR9a′, (CH2)rS(O)2C1-6 alkyl, S(O)2C1-6 trifluoromethyl, (CH2)rC(O)R9′, (CH2)rC(O)NR9dR9′, (CH2)rS(O)2R9′, R9′, and (CH2)rS(O)2NR9dR9′;
    R9′, at each occurrence, is independently selected from (CHR′)rC3-6 cycloalkyl substituted with 0-3 R9e, wherein the cycloalkyl is selected from cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl, (CHR′)rphenyl substituted with 0-3 R9c, (CHR′)r5-6 membered heterocycle system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R9c, wherein the heterocycle is selected from oxadiazolyl, morpholinyl, piperidinyl, tetrahydropyranyl, tetrahydrothiopyranyl, tetrahydrothiopyranyl dioxide, thiophene, imidazolyl, pyrrolidinyl, pyrrolyl, thiazolyl, and furanyl, and (CHR′)rphenyl substituted with 0-3 R9c;
    R9a, at each occurrence, is selected from CN, O-methyl, O-ethyl, CF3, OH, OC(O)-methyl, S-methyl, S-ethyl, S-propyl, S(O)p-methyl, S(O)p-ethyl, S(O)p-propyl, and NR9dR9d′;
    R9b, at each occurrence, is selected from cyclopropyl, cyclbutyl, cyclpentyl, CN, CF3, CH2—OC1-5 alkyl, CH2—OH, CH2—SC1-5 alkyl, and CH2—NR9dR9d′;
    R9c, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)rC(O)OC1-5 alkyl, (CH2)rC(O)C1-5 alkyl, (CH2)rC(O)NR9dR9d′, (CH2)rOH, (CH2)rSC1-5 alkyl, (CH2)rS(O)pC1-5 alkyl, and (CH2)rNR9dR9d′;
    provided that if R9c is attached to a carbon attached to the nitrogen on Ring B, then R9c is selected from (CH2)qOH, (CH2)qOC1-5 alkyl, (CH2)qSC1-5 alkyl, (CH2)qS(O)qC1-5 alkyl, and (CH2)qNR9dR9d′;
    R9d and R9d′, at each occurrence, are independently selected from H, methyl, ethyl, propyl, i-propyl, butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and phenyl;
    R9e, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)rC(O)OC1-5 alkyl, (CH2)rC(O)NR9dR9d′, (CH2)rOH, (CH2)rSC1-15 alkyl, (CH2)rS(O)pC1-5 alkyl, and (CH2)rNR9dR9d′, or alternatively, two R9e on the same carbon atom form ═O; and
    R9j, at each occurrence, is selected from cyclpropyl, cyclobutyl, cyclopentyl, CN, CF3, O-methyl, O-ethyl, O-propyl, O-i-propyl, O-butyl, OH, S-methyl, S-ethyl, and NR9dR9d′.


[5] In another embodiment, the present invention provides novel compounds of formula (I-i), wherein: 




    Z is selected from O, S, NCN, and NCONH2;
    R16, at each occurrence, is selected from C1-8 alkyl, (CH2)rC3-6 cycloalkyl, CF3, Cl, Br, I, F, (CH2)rNR16aR16a′, NO2, CN, OH, (CH2)rOR16d, (CH2)rC(O)R16b, (CH2)rC(O)NR16aR16a′, (CH2)rNR16fC(O)R16b, (CH2)rS(O)pR16b, (CH2)rS(O)2NR16aR16a′, (CH2)rNR16fS(C)2R16b, and (CH2)rphenyl substituted with 0-3 R16e;
    R16a and R16a′, at each occurrence, are selected from H, C1-6 alkyl, C3-6 cycloalkyl, and (CH2)rphenyl substituted with 0-3 R16e;
    R16b, at each occurrence, is selected from H, C1-6 alkyl, C3-6 cycloalkyl, and (CH2)rphenyl substituted with 0-3 R16e;
    R16d, at each occurrence, is selected from C1-6 alkyl and phenyl;
    R16e, at each occurrence, is selected from C1-6 alkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, OH, and (CH2)rOC1-5 alkyl; and
    R16f, at each occurrence, is selected from H, and C1-5 alkyl.


[6] In another embodiment, the present invention provides novel compounds of formula (I-ii), wherein: 




    Z is selected from O, S, NCN, and NCONH2;
    R16, at each occurrence, is selected from C1-8 alkyl, (CH2)rC3-6 cycloalkyl, CF3, Cl, Br, I, F, (CH2)rNR16aR16a′, NO2, CN, OH, (CH2)rOR16d, (CH2)rC(O)R16b, (CH2)rC(O)NR16aR16a′, (CH2)rNR16fC(O)R16b, (CH2)rS(O)pR16b, (CH2)rS(O)2NR16aR16a′, (CH2)rNR16fS(O)2R16b, and (CH2)rphenyl substituted with 0-3 R16e;
    R16a and R16a′, at each occurrence, are selected from H, C1-6 alkyl, C3-6 cycloalkyl, and (CH2)rphenyl substituted with 0-3 R16e;
    R16b, at each occurrence, is selected from H, C1-6 alkyl, C3-6 cycloalkyl, and (CH2)rphenyl substituted with 0-3 R16e;
    R16d, at each occurrence, is selected from C1-6 alkyl and phenyl;
    R16e, at each occurrence, is selected from C1-6 alkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, OH, and (CH2)rOC1-5 alkyl; and
    R16f, at each occurrence, is selected from H, and C1-5 alkyl.


[7] In another embodiment, the present invention provides novel compounds of formula (I-i), wherein:

    Ring B is a 5 or 6 membered saturated heterocycle ring, wherein the heterocycle ring is selected from piperidine, tetrahydropyran, tetrahydrothiopyran, tetrahydrothiopyran 1,1-dioxide, tetrahydrothiopyran 1-monooxide, piperidin-2-one, tetrahydropyran-2-one, [1,2]thiazinane 1,1-dioxide, pyrrolidine, tetrahydrofuran, tetrahydrothiophene, pyrrolidin-2-one, dihydrofuran-2-one, and isothiazolidine 1,1-dioxide, the heterocycle ring being optionally substituted by 0-2 R8;
    R5 is CH2 phenyl substituted with 0-3 R16;
    r is selected from 0, 1, and 2.


[8] In another embodiment, the present invention provides novel compounds of formula (I-ii), wherein:

    Ring B is a 5 or 6 membered saturated heterocycle ring, wherein the heterocycle ring is selected from piperidine, tetrahydropyran, tetrahydrothiopyran, tetrahydrothiopyran 1,1-dioxide, tetrahydrothiopyran 1-monooxide, piperidin-2-one, tetrahydropyran-2-one, [1,2]thiazinane 1,1-dioxide, pyrrolidine, tetrahydrofuran, tetrahydrothiophene, pyrrolidin-2-one, dihydrofuran-2-one, and isothiazolidine 1,1-dioxide, the heterocycle ring being optionally substituted by 0-2 R8;
    R5 is CH2phenyl substituted with 0-3 R16; and
    r is selected from 0, 1, and 2.


[9] In another embodiment, the present invention provides novel compounds of formula (I-i), wherein:

    J is selected from CH2 and CHR5;
    K is selected from CH2 and CHR5;
    L is CHR5;
    R3 is selected from a C3-10 carbocyclic residue substituted with 0-3 R15, wherein the carbocyclic residue is selected from cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, naphthyl and adamantyl, and a (CR3′H)r-heterocyclic system substituted with 0-3 R15, wherein the heterocyclic system is selected from pyridinyl, thiophenyl, furanyl, indazolyl, benzothiazolyl, benzimidazolyl, benzothiophenyl, benzofuranyl, benzoxazolyl, benzisoxazolyl, quinolinyl, isoquinolinyl, imidazolyl, indolyl, indolinyl, indazolyl, isoxazolinyl, morpholinyl, pyrrolidinyl, tetrahydropyranyl, tetrahydrofuranyl, isoindolyl, isothiadiazolyl, isoxazolyl, piperidinyl, pyrrazolyl, 1,2,4-triazolyl, 1,2,3-triazolyl, tetrazolyl, thiadiazolyl, thiazolyl, oxazolyl, pyrazinyl, and pyrimidinyl; and
    R15, at each occurrence, is selected from C1-8 alkyl, (CH2)rC3-6 cycloalkyl, CF3, Cl, Br, I, F, (CH2)rNR15aR15a′, NO2, CN, OH, (CH2)rOR15d, (CH2)rC(O)R15b, (CH2)rC(O)NR15aR15a′, (CH2)rNR15fC(O)R15b, (CH2)rNR15fC(O)O(CHR′)rR15d, (CH2)rOC(O)NR15aR15a′, (CH2)rS(O)pR15b, (CH2)rS(O)2NR15aR15a′, (CH2)rNR15fS (O)2R15b, (CH2)rphenyl substituted with 0-3 R15e, and a (CH2)r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R15e, wherein the heterocyclic system is selected from tetrazolyl, piperidinyl, pyrrolidinyl, imidazolyl, thiazolyl, pyrazolyl, pyridyl, thienyl, furanyl, pyrrolyl, oxazolyl, isoxazolyl, triazolyl, pyridazinyl, pyrimidinyl, pyrazinyl, morpholinyl, oxadiazolyl, and thiadiazolyl;
    R15a and R15a′, at each occurrence, are selected from H, C1-6 alkyl, C3-6 cycloalkyl, and (CH2)rphenyl substituted with 0-3 R15e;
    alternatively, R15a and R15a′, along with the N to which they are attached, join to form a 5-6 membered heterocyclic system containing 1-2 heteroatoms selected from NR15h, O, and S and optionally fused with a benzene ring or a 6-membered aromatic heterocycle;
    R15b, at each occurrence, is selected from H, C1-6 alkyl, C3-6 cycloalkyl, and (CH2)rphenyl substituted with 0-3 R15e;
    R15d, at each occurrence, is selected from C1-6 alkyl and phenyl;
    R15e, at each occurrence, is selected from C1-6 alkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, OH, and (CH2)rOC1-5 alkyl; and
    R15f, at each occurrence, is selected from H, and C1-5 alkyl.


[10] In another embodiment, the present invention provides novel compounds of formula (I-ii), wherein:

    K is selected from CH2 and CHR5;
    L is CHR5;
    R3 is selected from a C3-10 carbocyclic residue substituted with 0-3 R15, wherein the carbocyclic residue is selected from cyclopropyl, cyclopentyl, cyclohexyl, phenyl, naphthyl and adamantyl, and a (CR3′H)r-heterocyclic system substituted with 0-3 R15, wherein the heterocyclic system is selected from pyridinyl, thiophenyl, furanyl, indazolyl, benzothiazolyl, benzimidazolyl, benzothiophenyl, benzofuranyl, benzoxazolyl, benzisoxazolyl, quinolinyl, isoquinolinyl, imidazolyl, indazolyl, isoxazolinyl, morpholinyl, pyrrolidinyl, tetrahydropyranyl, tetrahydrofuranyl, indolyl, indolinyl, isoindolyl, isothiadiazolyl, isoxazolyl, piperidinyl, pyrrazolyl, 1,2,4-triazolyl, 1,2,3-triazolyl, tetrazolyl, thiadiazolyl, thiazolyl, oxazolyl, pyrazinyl, and pyrimidinyl; and
    R15, at each occurrence, is selected from C1-8 alkyl, (CH2)rC3-6 cycloalkyl, CF3, Cl, Br, I, F, (CH2)rNR15aR15a′, NO2, CN, OH, (CH2)rOR15d, (CH2)rC(O)R15b, (CH2)rC(O)NR15aR15a′, (CH2)rNR15fC(O)R15b, (CH2)rNR15fC(O)O(CHR′)rR15d, (CH2)rOC(O)NR15aR15a′, (CH2)rS(O)pR15b, (CH2)rS(O)2NR15aR15a′, (CH2)rNR15fS(O)2R15b, (CH2)rphenyl substituted with 0-3 R15e, and a (CH2)r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R15e, wherein the heterocyclic system is selected from tetrazolyl, piperidinyl, pyrrolidinyl, imidazolyl, thiazolyl, pyrazolyl, pyridyl, thienyl, furanyl, pyrrolyl, oxazolyl, isoxazolyl, triazolyl, pyridazinyl, pyrimidinyl, pyrazinyl, morpholinyl, oxadiazolyl, and thiadiazolyl;
    R15a and R15a′, at each occurrence, are selected from H, C1-6 alkyl, C3-6 cycloalkyl, and (CH2)rphenyl substituted with 0-3 R15e;
    alternatively, R15a and R15a′, along with the N to which they are attached, join to form a 5-6 membered heterocyclic system containing 1-2 heteroatoms selected from NR15h, O, and S and optionally fused with a benzene ring or a 6-membered aromatic heterocycle;
    R15b, at each occurrence, is selected from H, C1-6 alkyl, C3-6 cycloalkyl, and (CH2)rphenyl substituted with 0-3 R15e;
    R15d, at each occurrence, is selected from C1-6 alkyl and phenyl;
    R15e, at each occurrence, is selected from C1-6 alkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, OH, and (CH2)rOC1-5 alkyl; and
    R15f, at each occurrence, is selected from H, and C1-5 alkyl


[11] In another embodiment, the present invention provides novel compounds of formula (I), wherein the compound of formula (I) is: 




    G is selected from CH2 and C═O;
    L is CHR5;
    B is selected from piperidine, tetrahydropyran, tetrahydrothiopyran, pyrrolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, tetrahydrothiophene 1-oxide, and tetrahydrothiophene 1,1-dioxide;
    R3 is selected from phenyl substituted with 1-2 R15, —CH2—CH2-morpholin-1-yl substituted with 1-2 R15, indazolyl substituted with 1-2 R15, pyrazolyl substituted with 1-2 R15 or thiazolyl substituted with 1-2 R15;
    R5 is selected from a CH2-phenyl substituted with 1-2 R16;
    R9 is selected from H, C2-6 alkyl substituted with 0-3 R9a, wherein the alkyl is selected from methyl, ethyl, propyl, i-propyl, butyl, i-butyl, s-butyl, t-butyl, neo-pentyl; —CH2CH═CH2; —CH2C≡CH; 2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, (CH2)rC(O)C1-6 alkyl substituted with 0-2 R9j, wherein the alkyl is selected from methyl, ethyl, propyl, i-propyl, butyl, t-butyl; C(O)Omethyl, C(O)Ot-butyl, SO2methyl, SO2ethyl, SO2propyl, SO2i-propyl, SO2t-butyl, SO2CF3, (CH2)rC(O)NR9dR9d′; (CH2)rC(O)R9′, (CH2)rC(O)NR9dR9′, (CH2)rS(O)2R9′, R9′, and (CH2)rS(O)2NR9dR9′;
    R9′, at each occurrence, is independently selected from (CHR′)rC3-6 cycloalkyl, wherein the cycloalkyl is selected from cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl, (CHR′)rphenyl substituted with 0-3 R9c, (CHR′)r5-6 membered heterocycle system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R9c, wherein the heterocycle is selected from oxadiazolyl, morpholinyl, piperidinyl, tetrahydropyranyl, tetrahydrothiopyranyl, tetrahydrothiopyranyl dioxide, thiophene, imidazolyl, pyrrolidinyl, pyrrolyl, thiazolyl, and furanyl, and (CHR′)rphenyl substituted with 0-3 R9c;
    R9a, at each occurrence, is selected from CN, O-methyl, O-ethyl, CF3, OH, OC(O)-methyl, S-methyl, S-ethyl, S-propyl, S(O)p-methyl, S(O)p-ethyl, S(O)p-propyl, and NR9dR9d′;
    R9c, at each occurrence, is selected from methyl, ethyl, propyl, C(O)-methyl, C(O)O-t-butyl;
    R9d and R9d′, at each occurrence, are independently selected from H, methyl, ethyl, propyl, i-propyl, butyl, t-butyl;
    R9, at each occurrence, is selected from O-methyl, O-ethyl, and NR9dR9d′;
    R15 is selected from Me, CF3, OMe, OCF3, F, Cl, Br, OH, OMe, C(O)Me, CH(OH)Me, CN, CO2Me, CO2Et, SO2NH2, NHC(O)Me, C(O)NH2, C(O)NHMe, C(O)NHCH2CH2OMe, C(O)piperidinyl, C(O)pyrrolidinyl, C(O)morpholinyl, and a 5-6 membered heterocyclic system, wherein the heterocyclic system is selected from tetrazolyl, indazolyl, pyrazolyl, triazolyl, morpholinyl, and thiazolyl, the heterocyclic system substituted with 0-2 R15e;
    R15e is selected from methyl, ethyl, propyl, i-propyl, cyclopropyl, cyclopropylmethyl, acetyl, and t-butoxycarbonyl;
    R16 is selected from F, Cl, Br, and I;


[12] In another embodiment, the present invention provides novel compounds of formula (I), wherein the compounds are selected from:

    (3R,4R)-4-[3-(3-acetyl-phenyl)-ureido]-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidine-1-carboxylic acid t-butyl ester;
    1-(3-acetyl-phenyl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidin-4-yl}-urea;
    (3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-4-{3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-ureido}-piperidine-1-carboxylic acid t-butyl ester;
    1-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidin-4-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{1-(2,2-Dimethyl-propionyl)-3-[(3R,4R)-3-((S)-4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidin-4-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{1-Acetyl-3-[(3R,4R)-3-((S)-4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidin-4-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{(3R,4R)-3-[(S)-3-(4-Fluoro-benzyl)-piperidine-1-carbonyl]-1-methanesulfonyl-piperidin-4-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{(3R,4R)-3-[(S)-3-(4-Fluoro-benzyl)-piperidine-1-carbonyl]-1-methyl-piperidin-4-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    5-(3-{(3R,4R)-1-tert-butoxycarbonyl-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidin-4-yl}-ureido)-indazole-1-carboxylic acid t-butyl ester;
    5-(3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidin-4-yl}-ureido)-indazole-1-carboxylic acid t-butyl ester;
    (3R,4R)-4-[3-(5-acetyl-4-methyl-thiazol-2-yl)-ureido]-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidine-1-carboxylic acid t-butyl ester;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidin-4-yl}-urea;
    (3R,4S)-3-[3-(3-acetyl-phenyl)-ureido]-4-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidine-1-carboxylic acid t-butyl ester;
    1-(3-acetyl-phenyl)-3-{(3R,4R)-4-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidin-3-yl}-urea;
    (3R,4R)-4-[3-(3-acetyl-phenyl)-ureido]-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid t-butyl ester;
    1-(3-acetyl-phenyl)-3-{(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea;
    1-{(3R,4R)-1-acetyl-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-3-(3-acetyl-phenyl)-urea;
    1-(3-acetyl-phenyl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-methanesulfonyl-piperidin-4-yl}-urea;
    1-(3-acetyl-phenyl)-3-{(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-methyl-piperidin-4-yl}-urea;
    1-(3-acetyl-phenyl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-isobutyl-piperidin-4-yl}-urea;
    (3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-4-{3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-ureido}-piperidine-1-carboxylic acid t-butyl ester;
    1-{(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    5-(3-{(3R,4R)-1-t-butoxycarbonyl-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-ureido)-indazole-1-carboxylic acid t-butyl ester;
    5-(3-{(3S,4R)-3-[(S)-3-(4-Fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-ureido)-indazole-1-carboxylic acid t-butyl ester;
    (3R,4R)-4-[3-(5-acetyl-4-methyl-thiazol-2-yl)-ureido]-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid t-butyl ester;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea;
    (3R,4R)-4-[3-(3-acetyl-phenyl)-ureido]-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid t-butyl ester;
    1-(3-acetyl-phenyl)-3-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-urea;
    (3S,4R)-4-[3-(3-acetyl-phenyl)-ureido]-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidine-1-carboxylic acid t-butyl ester;
    1-(3-acetyl-phenyl)-3-{(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidin-4-yl}-urea;
    (3R,4R)-4-[3-(3-acetyl-phenyl)-ureido]-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid methyl ester;
    1-(3-acetyl-phenyl)-3-{(3R,4R)-1-(2,2-dimethyl-propionyl)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea;
    (3R,4S)-3-[3-(5-acetyl-4-methyl-thiazol-2-yl)-ureido]-4-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidine-1-carboxylic acid t-butyl ester;
    1-(3-acetyl-phenyl)-3-{(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-fluoro-ethyl)-piperidin-4-yl}-urea;
    1-(3-acetyl-phenyl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-oxo-propyl)-piperidin-4-yl}-urea;
    1-(3-acetyl-phenyl)-3-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-methyl-piperidin-3-yl}-urea;
    1-{(3R,4S)-1-Acetyl-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-3-(3-acetyl-phenyl)-urea;
    1-{(3R,4R)-1-acetyl-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-3-(1-methyl-1H-tetrazol-5-yl)-urea;
    1-{(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-methyl-piperidin-4-yl}-3-(1-methyl-1H-tetrazol-5-yl)-urea;
    1-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-methanesulfonyl-piperidin-4-yl}-3-(1-methyl-1H-tetrazol-5-yl)-urea;
    1-{(3R,4R)-3-[(S)-3-(4-Fluoro-benzyl)-piperidine-1-carbonyl]-1-(2-oxo-propyl)-piperidin-4-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{(3R,4R)-3-[(S)-3-(4-Fluoro-benzyl)-piperidine-1-carbonyl]-1-(2-fluoro-ethyl)-piperidin-4-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{(3R,4R)-3-[(S)-3-(4-Fluoro-benzyl)-piperidine-1-carbonyl]-1-trifluoromethanesulfonyl-piperidin-4-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-(3-Acetyl-phenyl)-3-{(2S,3R)-2-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-yl}-urea;
    1-{(2S,3R)-2-[(S)-3-(4-Fluoro-benzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{(2S,3R)-2-[(S)-3-(4-Fluoro-benzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-yl}-3-(5-acetyl-4-methyl-thiazol-2-yl)-urea;
    1-(3-Acetyl-phenyl)-3-{(2S,3R)-2-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-tetrahydro-pyran-3-yl}-urea;
    1-{(2S,3R)-2-[(S)-3-(4-Fluoro-benzyl)-piperidine-1-carbonyl]-tetrahydro-pyran-3-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{(2S,3R)-2-[(S)-3-(4-Fluoro-benzyl)-piperidine-1-carbonyl]-tetrahydro-pyran-3-yl}-3-(5-acetyl-4-methyl-thiazol-2-yl)-urea;
    1-{(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-methyl-piperidin-4-yl}-3-(5-acetyl-4-methyl-thiazol-2-yl)-urea;
    1-{(3R,4R)-1-acetyl-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-3-(5-acetyl-4-methyl-thiazol-2-yl)-urea;
    1-(5-Acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-isobutyryl-piperidin-4-yl}-urea;
    1-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-methanesulfonyl-piperidin-4-yl)-3-(5-acetyl-4-methyl-thiazol-2-yl)-urea;
    1-{(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-fluoroethyl)-piperidin-4-yl}-3-(5-acetyl-4-methyl-thiazol-2-yl)-urea;
    1-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-oxopropyl)-piperidin-4-yl}-3-(5-acetyl-4-methyl-thiazol-2-yl)-urea;
    1-(3-Acetyl-phenyl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-4-yl}-urea;
    1-{(3R,4R)-3-[(S)3-(4-Fluoro-benzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-4-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{(3R,4R)-3-[(S)3-(4-Fluoro-benzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-4-yl}-3-(5-acetyl-4-methyl-thiazol-2-yl)-urea;
    1-(3-Acetyl-phenyl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-tetrahydro-pyran-4-yl}-urea;
    1-{(3R,4R)-3-[(S)3-(4-Fluoro-benzyl)-piperidine-1-carbonyl]-tetrahydro-pyran-4-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-((3R,4R)-3-[(S)3-(4-Fluoro-benzyl)-piperidine-1-carbonyl]-tetrahydro-pyran-4-yl}-3-(5-acetyl-4-methyl-thiazol-2-yl)-urea;
    1-{(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-3-(4-fluoro-phenyl)-urea;
    (3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-4-[3-(4-fluoro-phenyl)-ureido]-piperidine-1-carboxylic acid t-butyl ester;
    1-{(3R,4R)-1-acetyl-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-3-(4-fluoro-phenyl)-urea;
    1-{(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-methyl-piperidin-4-yl)-3-(4-fluoro-phenyl)-urea;
    1-{(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-ethyl-piperidin-4-yl}-3-(4-fluoro-phenyl)-urea;
    1-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-[1,2,4]oxadiazol-3-ylmethyl-piperidin-4-yl}-3-(4-fluoro-phenyl)-urea;
    2-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-4-[3-(4-fluoro-phenyl)-ureido]-piperidin-1-yl}-N-isopropyl-acetamide;
    1-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-prop-2-ynyl-piperidin-4-yl}-3-(4-fluoro-phenyl)-urea;
    1-(3-acetyl-phenyl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-[1,4′]bipiperidinyl-4-yl}-urea;
    1-{(3R,4R)-1′-acetyl-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-[1,4′]bipiperidinyl-4-yl}-3-(3-acetyl-phenyl)-urea;
    1-(3-acetyl-phenyl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1′-methyl-[1,4′]bipiperidinyl-4-yl}-urea;
    1-(3,5-diacetyl-phenyl)-3-{(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea;
    (3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-4-[3-(3,5-diacetyl-phenyl)-ureido]-piperidine-1-carboxylic acid t-butyl ester;
    1-(3,5-diacetyl-phenyl)-3-{(3R,4R)-1-acetyl-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea;
    1-(3,5-diacetyl-phenyl)-3-{(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-methyl-piperidin-4-yl}-urea;
    1-(3,5-diacetyl-phenyl)-3-{(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-ethyl-piperidin-4-yl}-urea;
    1-(3,5-diacetyl-phenyl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-[1,2,4]oxadiazol-3-ylmethyl-piperidin-4-yl}-urea;
    2-{(3R,4R)-3-[(S)-3-(4-Fluoro-benzyl)-piperidin-1-ylmethyl]-4-[3-(3,5-diacetyl-phenyl)-ureido]-piperidin-1-yl)-N-isopropyl-acetamide;
    1-(3,5-diacetyl-phenyl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-propargyl-piperidin-4-yl}-urea;
    (3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-4-{3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-ureido}-piperidine-1-carboxylic acid methyl ester;
    1-{(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-5-[3-methyl-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    (3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-4-{3-[3-methyl-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-ureido}-piperidine-1-carboxylic acid t-butyl ester;
    1-{(3R,4R)-1-acetyl-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-3-[3-methyl-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-methyl-piperidin-4-yl}-3-[3-methyl-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-ethyl-piperidin-4-yl}-3-[3-methyl-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-[1,2,4]oxadiazol-3-ylmethyl-piperidin-4-yl}-3-[3-methyl-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    2-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-4-{3-[3-methyl-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-ureido}-piperidin-1-yl}-N-isopropyl-acetamide;
    1-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-prop-2-ynyl-piperidin-4-yl}-3-[3-methyl-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-3-[3-bromo-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    (3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-4-{3-[3-bromo-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-ureido}-piperidine-1-carboxylic acid t-butyl ester;
    1-((3R,4R)-1-acetyl-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-3-[3-bromo-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-methyl-piperidin-4-yl}-3-[3-bromo-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-ethyl-piperidin-4-yl}-3-[3-bromo-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-[1,2,4]oxadiazol-3-ylmethyl-piperidin-4-yl}-3-[3-bromo-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    2-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-4-{3-[3-bromo-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-ureido}-piperidin-1-yl}-N-isopropyl-acetamide;
    1-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-prop-2-ynyl-piperidin-4-yl}-3-[3-bromo-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-[(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-oxo-propyl)-piperidin-4-yl]-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-oxo-propyl)-piperidin-4-yl}-3-(1-methyl-pyrazol-3-yl)-urea;
    1-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-oxo-propyl)-piperidin-4-yl}-3-(thiazol-2-yl)-urea;
    2-{3-[(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-oxo-propyl)-piperidin-4-yl]-ureido}-4-methyl-thiazole-5-carboxylic acid ethyl ester;
    (3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-4-(5-acetyl-4-methyl-thiazol-2-yl)-ureido}-piperidine-1-carboxylic acid methyl ester;
    (3R,4R)-4-[3-(5-acetyl-4-methyl-thiazol-2-yl)-ureido]-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid 3-hydroxy-2,2-dimethyl-propyl ester;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-propionyl-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-1-cyclopropanecarbonyl-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-1-cyclopentanecarbonyl-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-[(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(tetrahydro-pyran-4-carbonyl)-piperidin-4-yl]-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-[(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-methoxy-acetyl)-piperidin-4-yl]-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-[(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-dimethylamino-acetyl)-piperidin-4-yl]-urea;
    (3R,4R)-4-[3-(5-acetyl-4-methyl-thiazol-2-yl)-ureido]-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid methylamide;
    (3R,4R)-4-[3-(5-acetyl-4-methyl-thiazol-2-yl)-ureido]-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid dimethylamide;
    (3R,4R)-4-[3-(5-acetyl-4-methyl-thiazol-2-yl)-ureido]-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid ethylamide;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3S,4R)-1-ethyl-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-propyl-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-isopropyl-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-1-cyclobutyl-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl)-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-1-cyclopentyl-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-[(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(tetrahydro-pyran-4-yl)-piperidin-4-yl]-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-[(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(tetrahydro-thiopyran-4-yl)-piperidin-4-yl]-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-1-(1,1-dioxo-hexahydro-1λ6-thiopyran-4-yl)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-[1,4′]bipiperidinyl-4-yl}-urea;
    (3R,4R)-4-[3-(5-acetyl-4-methyl-thiazol-2-yl)-ureido]-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-[1,4′]bipiperidinyl-1′-carboxylic acid tert-butyl ester;
    1-{(3R,4R)-1′-acetyl-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-[1,4′]bipiperidinyl-4-yl}-3-(5-acetyl-4-methyl-thiazol-2-yl)-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1′-methyl-[1,4′]bipiperidinyl-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-1-cyclopropylmethyl-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-1-cyclobutylmethyl-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-1-benzyl-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-furan-2-ylmethyl-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-furan-3-ylmethyl-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-thiophen-2-ylmethyl-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-((3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-thiophen-3-ylmethyl-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-imidazol-2-ylmethyl-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-imidazol-4-ylmethyl-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-thiazol-2-ylmethyl-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-[1,2,4]oxadiazol-3-ylmethyl-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-hydroxyethyl)-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-hydroxy-2-methylpropyl)-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-hydroxy-3,3,3-trifluoropropyl)-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-methoxy-ethyl)-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-1-(2-ethoxy-ethyl)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-1-(2-ethylsulfanyl-ethyl)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-1-(2-ethanesulfonyl-ethyl)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-1-(2-acetoxy-ethyl)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-1-cyanomethyl-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-1-(2-dimethylamino-ethyl)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-1-(2-diethylamino-ethyl)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-[(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-pyrrolidin-1-yl-ethyl)-piperidin-4-yl]-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-[(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-morpholin-1-yl-ethyl)-piperidin-4-yl]-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-[(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-pyrrol-1-yl-ethyl)-piperidin-4-yl]-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-[(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(3-oxo-butyl)-piperidin-4-yl]-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-[(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-methyl-3-oxo-butyl)-piperidin-4-yl]-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-[(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(3-hydroxypropyl)-piperidin-4-yl]-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-[(S)-3-hydroxy-2-methylpropyl]-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-[(R)-3-hydroxy-2-methylpropyl]-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-1-(3,3-dimethyl-2-oxo-butyl)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea;
    2-{(3R,4R)-4-[3-(5-acetyl-4-methyl-thiazol-2-yl)-ureido]-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-1-yl}-N-methyl-acetamide;
    2-{(3R,4R)-4-[3-(5-acetyl-4-methyl-thiazol-2-yl)-ureido]-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-1-yl}-N-isopropyl-acetamide;
    2-{(3R,4R)-4-[3-(5-acetyl-4-methyl-thiazol-2-yl)-ureido]-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-1-yl}-N-tert-butyl-acetamide;
    2-{(3R,4R)-4-[3-(5-acetyl-4-methyl-thiazol-2-yl)-ureido]-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-1-yl}-N,N-dimethyl-acetamide;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-[(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-oxo-cyclopentyl)-piperidin-4-yl]-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-1-allyl-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-prop-2-ynyl-piperidin-4-yl}-urea;
    1-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-3-(4-fluoro-phenyl)-urea;
    1-{(3R,4S)-1-acetyl-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-3-(4-fluoro-phenyl)-urea;
    1-[(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-methoxy-acetyl)-piperidin-3-yl]-3-(4-fluoro-phenyl)-urea;
    1-{(3R,4S)-1-cyclopropylmethyl-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-3-(4-fluoro-phenyl)-urea;
    1-[(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-hydroxy-ethyl)-piperidin-3-yl]-3-(4-fluoro-phenyl)-urea;
    1-(3-acetyl-phenyl)-3-[(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-methoxy-acetyl)-piperidin-3-yl]-urea;
    1-(3-acetyl-phenyl)-3-{(3R,4S)-1-(2-dimethylamino-acetyl)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-urea;
    (3R,4S)-3-[3-(3-acetyl-phenyl)-ureido]-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid ethylamide;
    1-(3-acetyl-phenyl)-3-[(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-hydroxy-ethyl)-piperidin-3-yl]-urea;
    (3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-3-{3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-ureido}-piperidine-1-carboxylic acid tert-butyl ester;
    1-{(3R,4S)-1-acetyl-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{(3R,4S)-1-(2,2-dimethyl-propionyl)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-methyl-piperidin-3-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-3-[3-methyl-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-[(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-hydroxy-ethyl)-piperidin-3-yl]-3-[3-methyl-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-[3-bromo-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-3-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-urea;
    1-[3-bromo-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-3-[(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-hydroxy-ethyl)-piperidin-3-yl]-urea;
    1-{(3R,4S)-1-acetyl-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-3-[3-(5-methyl-tetrazol-1-yl)-phenyl]-urea;
    1-{(3R,4S)-1-acetyl-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-3-(1-methyl-pyrazol-3-yl)-urea;
    1-{(3R,4S)-1-acetyl-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-3-(thiazol-2-yl)-urea;
    2-(3-{(3R,4S)-1-acetyl-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-ureido)-4-methyl-thiazole-5-carboxylic acid ethyl ester;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-urea;
    (3R,4S)-3-[3-(5-acetyl-4-methyl-thiazol-2-yl)-ureido]-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid methyl ester;
    (3R,4S)-3-[3-(5-acetyl-4-methyl-thiazol-2-yl)-ureido]-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid tert-butyl ester;
    1-{(3R,4S)-1-acetyl-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-3-(5-acetyl-4-methyl-thiazol-2-yl)-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-propionyl-piperidin-3-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-methyl-propionyl)-piperidin-3-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4S)-1-(2,2-dimethyl-propionyl)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4S)-1-cyclopropanecarbonyl-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4S)-1-cyclobutanecarbonyl-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4S)-1-cyclopentanecarbonyl-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4S)-1-cyclohexanecarbonyl-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(tetrahydro-pyran-4-carbonyl)-piperidin-3-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-methoxy-acetyl)-piperidin-3-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4S)-1-(2-dimethylamino-acetyl)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-urea;
    (3R,4S)-3-[3-(5-acetyl-4-methyl-thiazol-2-yl)-ureido]-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid methylamide;
    (3R,4S)-3-[3-(5-acetyl-4-methyl-thiazol-2-yl)-ureido]-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid ethylamide;
    (3R,4S)-3-[3-(5-acetyl-4-methyl-thiazol-2-yl)-ureido]-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid propylamide;
    (3R,4S)-3-[3-(5-acetyl-4-methyl-thiazol-2-yl)-ureido]-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid isopropylamide;
    (3R,4S)-3-[3-(5-acetyl-4-methyl-thiazol-2-yl)-ureido]-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid allylamide;
    (3R,4S)-3-[3-(5-acetyl-4-methyl-thiazol-2-yl)-ureido]-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid (5-acetyl-4-methyl-thiazol-2-yl)-amide;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-methyl-piperidin-3-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-[1,4′]bipiperidinyl-3-yl}-urea;
    1-{(3R,4S)-1′-acetyl-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-[1,4′]bipiperidinyl-3-yl}-3-(5-acetyl-4-methyl-thiazol-2-yl)-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1′-methyl-[1,4′]bipiperidinyl-3-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4S)-1-cyclopropylmethyl-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-[(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(tetrahydro-pyran-2-ylmethyl)-piperidin-3-yl]-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-furan-2-ylmethyl-piperidin-3-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-furan-3-ylmethyl-piperidin-3-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-[1,2,4]oxadiazol-3-ylmethyl-piperidin-3-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-fluoro-ethyl)-piperidin-3-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-hydroxy-ethyl)-piperidin-3-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-((3R,4S)-1-(2-ethanesulfonyl-ethyl)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl)-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4S)-1-cyanomethyl-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-hydroxy-propyl)-piperidin-3-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-[(S)-2-hydroxy-2-methyl-propyl]-piperidin-3-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-[(R)-2-hydroxy-2-methyl-propyl]-piperidin-3-yl}-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-oxo-propyl)-piperidin-3-yl}-urea;
    2-{(3R,4S)-3-[3-(5-acetyl-4-methyl-thiazol-2-yl)-ureido]-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-1-yl}-N,N-dimethyl-acetamide;
    1-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-isobutyryl-piperidin-3-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{(3R,4S)-1-benzoyl-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(propane-2-sulfonyl)-piperidin-3-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-3-(2-morpholin-4-yl-ethyl)-urea;
    (3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-3-[3-(2-morpholin-4-yl-ethyl)-ureido]-piperidine-1-carboxylic acid methyl ester;
    1-{(3R,4S)-1-acetyl-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-3-(2-morpholin-4-yl-ethyl)-urea;
    1-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-propionyl-piperidin-3-yl}-3-(2-morpholin-4-yl-ethyl)-urea;
    1-{(3R,4S)-1-(2,2-dimethyl-propionyl)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-3-(2-morpholin-4-yl-ethyl)-urea;
    1-{(3R,4S)-1-cyclobutanecarbonyl-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-3-(2-morpholin-4-yl-ethyl)-urea;
    1-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(tetrahydro-pyran-4-carbonyl)-piperidin-3-yl}-3-(2-morpholin-4-yl-ethyl)-urea;
    1-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-methoxy-acetyl)-piperidin-3-yl}-3-(2-morpholin-4-yl-ethyl)-urea;
    (3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-3-[3-(2-morpholin-4-yl-ethyl)-ureido]-piperidine-1-carboxylic acid dimethylamide;
    (3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-3-[3-(2-morpholin-4-yl-ethyl)-ureido]-piperidine-1-carboxylic acid ethylamide;
    1-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-methanesulfonyl-piperidin-3-yl}-3-(2-morpholin-4-yl-ethyl)-urea;
    1-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-methyl-piperidin-3-yl}-3-(2-morpholin-4-yl-ethyl)-urea;
    1-{(3R,4S)-1-ethyl-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-3-(2-morpholin-4-yl-ethyl)-urea;
    1-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-isopropyl-piperidin-3-yl}-3-(2-morpholin-4-yl-ethyl)-urea;
    1-{(3R,4S)-1-cyclopropylmethyl-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-3-(2-morpholin-4-yl-ethyl)-urea;
    1-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-oxo-propyl)-piperidin-3-yl}-3-(2-morpholin-4-yl-ethyl)-urea;
    1-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-yl}-3-[3-methyl-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-yl}-urea;
    (3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-4-[3-(4-fluoro-phenyl)-ureido]-piperidine-1-carboxylic acid methyl ester;
    1-{(3R,4R)-1-(2-dimethylamino-acetyl)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-3-(4-fluoro-phenyl)-urea;
    1-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-methanesulfonyl-piperidin-4-yl}-3-(4-fluoro-phenyl)-urea;
    1-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-thiazol-2-ylmethyl-piperidin-4-yl}-3-(4-fluoro-phenyl)-urea;
    1-[(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-hydroxy-ethyl)-piperidin-4-yl]-3-(4-fluoro-phenyl)-urea;
    1-[(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-methoxy-ethyl)-piperidin-4-yl]-3-(4-fluoro-phenyl)-urea;
    1-[(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-morpholin-4-yl-ethyl)-piperidin-4-yl]-3-(4-fluoro-phenyl)-urea;
    1-[(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-hydroxy-propyl)-piperidin-4-yl]-3-(4-fluoro-phenyl)-urea;
    (3R,4R)-4-[3-(3,5-diacetyl-phenyl)-ureido]-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid methyl ester;
    1-(3,5-diacetyl-phenyl)-3-{(3R,4R)-1-(2-dimethylamino-acetyl)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea;
    1-(3,5-diacetyl-phenyl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-methanesulfonyl-piperidin-4-yl}-urea;
    1-(3,5-diacetyl-phenyl)-3-{(3R,4R)-1-(1,1-dioxo-hexahydro-1λ6-thiopyran-4-yl)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea;
    1-(3,5-diacetyl-phenyl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-thiazol-2-ylmethyl-piperidin-4-yl}-urea;
    1-(3,5-diacetyl-phenyl)-3-[(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-hydroxy-ethyl)-piperidin-4-yl]-urea;
    1-(3,5-diacetyl-phenyl)-3-[(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-methoxy-ethyl)-piperidin-4-yl]-urea;
    1-(3,5-diacetyl-phenyl)-3-[(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-morpholin-4-yl-ethyl)-piperidin-4-yl]-urea;
    1-(3,5-diacetyl-phenyl)-3-[(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-hydroxy-propyl)-piperidin-4-yl]-urea;
    (3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-4-{3-[3-methyl-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-ureido}-piperidine-1-carboxylic acid methyl ester;
    1-{(3R,4R)-1-(2-dimethylamino-acetyl)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-3-[3-methyl-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-methanesulfonyl-piperidin-4-yl}-3-[3-methyl-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-thiazol-2-ylmethyl-piperidin-4-yl}-3-[3-methyl-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-[(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-hydroxy-ethyl)-piperidin-4-yl]-3-[3-methyl-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-[(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-methoxy-ethyl)-piperidin-4-yl]-3-[3-methyl-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-[(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-morpholin-4-yl-ethyl)-piperidin-4-yl]-3-[3-methyl-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-[(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-hydroxy-propyl)-piperidin-4-yl]-3-[3-methyl-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    (3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-4-{3-[3-bromo-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-ureido}-piperidine-1-carboxylic acid methyl ester;
    1-{(3R,4R)-1-(2-dimethylamino-acetyl)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-3-[3-bromo-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-methanesulfonyl-piperidin-4-yl}-3-[3-bromo-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-thiazol-2-ylmethyl-piperidin-4-yl}-3-[3-bromo-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-[(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-hydroxy-ethyl)-piperidin-4-yl]-3-[3-bromo-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-[(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-methoxy-ethyl)-piperidin-4-yl]-3-[3-bromo-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-[(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-morpholin-4-yl-ethyl)-piperidin-4-yl]-3-[3-bromo-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-[(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-(2-hydroxy-propyl)-piperidin-4-yl]-3-[3-bromo-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    (3R,4S)-3-(3-benzyl-ureido)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid tert-butyl ester;
    1-benzyl-3-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-urea;
    (3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-3-[3-(tetrahydro-pyran-4-ylmethyl)-ureido]-piperidine-1-carboxylic acid tert-butyl ester;
    1-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-3-(tetrahydro-pyran-4-ylmethyl)-urea;
    (3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-3-{3-[2-(tetrahydro-pyran-4-yl)-ethyl]-ureido}-piperidine-1-carboxylic acid tert-butyl ester;
    1-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl)-3-[2-(tetrahydro-pyran-4-yl)-ethyl]-urea;
    1-{(3S,4S)-4-[(S)-3-(4-Fluoro-benzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-yl}-3-[3-methyl-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{(3S,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{(3S,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-yl}-3-[5-acetyl-4-methylthiazol-2-yl]-urea;
    1-{(3S,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-yl}-3-(3-acetylphenyl)-urea;
    1-{(3S,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-yl}-3-(2-morpholin-4-yl-ethyl)-urea;
    1-{(3S,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-1,1-dioxo-tetrahydrothiophen-3-yl}-3-[5-acetyl-4-methylthiazol-2-yl]-urea;
    1-{(3S,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-1,1-dioxo-tetrahydrothiophen-3-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea;
    1-{(3S,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-1,1-dioxo-tetrahydrothiophen-3-yl}-3-[3-acetylphenyl]-urea;
    1-{(3S,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-1,1-dioxo-tetrahydrothiophen-3-yl}-3-(2-morpholin-4-yl-ethyl)-urea;
    1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidine-1-carbonyl]-1,1-dioxo-tetrahydro-1λ6-thiophen-3-yl}-urea;
    1-((3R,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidine-1-carbonyl]-1,1-dioxo-tetrahydrothiophen-3-yl}-3-(2-morpholin-4-yl-ethyl)-urea;
    (3S,4S)-3-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-4-{3-[3-methyl-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-ureido}-pyrrolidine-1-carboxylic acid tert-butyl ester;
    1-(5-acetyl-4-methylthiazol-2-yl)-3-{(3S,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-pyrrolidin-3-yl}-urea.


In another embodiment, the present invention provides a pharmaceutical composition, comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of the present invention.
In another embodiment, the present invention provides a method for modulation of chemokine receptor activity comprising administering to a patient in need thereof a therapeutically effective amount of a compound of the present invention.
In another embodiment, the present invention provides a method for treating inflammatory disorders comprising administering to a patient in need thereof a therapeutically effective amount of a compound of the present invention
In another embodiment, the present invention provides a method for treating or preventing disorders selected from asthma, allergic rhinitis, atopic dermatitis, inflammatory bowel diseases, idiopathic pulmonary fibrosis, bullous pemphigoid, helminthic parasitic infections, allergic colitis, eczema, conjunctivitis, transplantation, familial eosinophilia, eosinophilic cellulitis, eosinophilic pneumonias, eosinophilic fasciitis, eosinophilic gastroenteritis, drug induced eosinophilia, HIV infection, cystic fibrosis, Churg-Strauss syndrome, lymphoma, Hodgkin's disease, and colonic carcinoma.
In another embodiment, the present invention provides a method for treating or preventing disorders selected from asthma, allergic rhinitis, atopic dermatitis, and inflammatory bowel diseases.
In another embodiment, the present invention provides a method for treating or preventing asthma.
In another embodiment, the compound of Formula (I) is 




In another embodiment, the compound of Formula (I) is 




In another embodiment, J is CH2, K is selected from CH2 and CHR5, and L is selected from CH2 and CHR5, wherein at least one of K or L contains an R5.
In another embodiment, K is CH2.
In another embodiment, L is CH2.
In another embodiment, Z is selected from O, S, NCN, and NCONH2.
In another embodiment, E is 




In another embodiment, E is 




In another embodiment, Ring B is piperidine, tetrahydropyran, tetrahydrothiopyran, tetrahydrothiopyran 1,1-dioxide, piperidin-2-one, tetrahydropyran-2-one, [1,2]thiazinane 1,1-dioxide, pyrrolidine, tetrahydrofuran, tetrahydrothiophene, pyrrolidin-2-one, dihydrofuran-2-one, and isothiazolidine 1,1-dioxide.
In another embodiment, Ring B is piperidine, tetrahydropyran, tetrahydrothiopyran, tetrahydrothiopyran 1,1-dioxide, piperidin-2-one, tetrahydropyran-2-one, [1,2]thiazinane 1,1-dioxide, pyrrolidine, tetrahydrofuran, tetrahydrothiophene, pyrrolidin-2-one, dihydrofuran-2-one, and isothiazolidine 1,1-dioxide.
In another embodiment, Ring B is piperidine and tetrahydropyran.
In another embodiment, R1 and R2 are H.
In another embodiment, R3 is selected from a (CR3′H)r-carbocyclic residue substituted with 0-5 R15, wherein the carbocyclic residue is selected from phenyl, C3-6 cycloalkyl, naphthyl, and adamantyl; and a (CR3′H)r-heterocyclic system substituted with 0-3 R15, wherein the heterocyclic system is selected from pyridinyl, thiophenyl, furanyl, indazolyl, benzothiazolyl, benzimidazolyl, benzothiophenyl, benzofuranyl, benzoxazolyl, benzisoxazolyl, quinolinyl, isoquinolinyl, imidazolyl, indolyl, indolinyl, isoindolyl, isothiadiazolyl, isoxazolyl, piperidinyl, pyrrazolyl, 1,2,4-triazolyl, 1,2,3-triazolyl, tetrazolyl, thiadiazolyl, thiazolyl, oxazolyl, pyrazinyl, and pyrimidinyl.
In another embodiment, R3 is selected from a methyl substituted with 0-2 R10, C2-8 alkyl substituted with 0-2 R7, a C3-10 carbocyclic residue substituted with 0-3 R15, wherein the carbocyclic residue is selected from cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, naphthyl and adamantyl, and a (CR3′H)r-heterocyclic system substituted with 0-3 R15, wherein the heterocyclic system is selected from pyridinyl, thiophenyl, furanyl, indazolyl, benzothiazolyl, benzimidazolyl, benzothiophenyl, benzofuranyl, benzoxazolyl, benzisoxazolyl, quinolinyl, isoquinolinyl, imidazolyl, indolyl, indolinyl, isoindolyl, isothiadiazolyl, isoxazolyl, piperidinyl, pyrrazolyl, 1,2,4-triazolyl, 1,2,3-triazolyl, tetrazolyl, thiadiazolyl, thiazolyl, oxazolyl, pyrazinyl, and pyrimidinyl.
In another embodiment, R3 is selected from a phenyl substituted with 0-2 R15; and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R15, wherein the heterocyclic system is selected from pyridinyl, morpholinyl, pyrazolyl, indazolyl, thiazolyl and r is 0, 1, or 2.
In another embodiment, R5 is selected from (CR5′H)t-phenyl substituted with 0-5 R16; and a (CR5′H)t-heterocyclic system substituted with 0-3 R16, wherein the heterocyclic system is selected from pyridinyl, thiophenyl, furanyl, indazolyl, benzothiazolyl, benzimidazolyl, benzothiophenyl, benzofuranyl, benzoxazolyl, benzisoxazolyl, quinolinyl, isoquinolinyl, imidazolyl, indolyl, indolinyl, isoindolyl, isothiadiazolyl, isoxazolyl, piperidinyl, pyrrazolyl, 1,2,4-triazolyl, 1,2,3-triazolyl, tetrazolyl, thiadiazolyl, thiazolyl, oxazolyl, pyrazinyl, and pyrimidinyl.
In another embodiment, R5 is selected from a CH2—C3-10 carbocyclic residue substituted with 1-5 R16 and a heterocyclic system substituted with 0-3 R15, wherein the heterocyclic system is selected from pyridinyl, thiophenyl, furanyl, indazolyl, benzothiazolyl, benzimidazolyl, benzothiophenyl, benzofuranyl, benzoxazolyl, benzisoxazolyl, quinolinyl, isoquinolinyl, imidazolyl, indolyl, indolinyl, isoindolyl, isothiadiazolyl, isoxazolyl, piperidinyl, pyrrazolyl, 1,2,4-triazolyl, 1,2,3-triazolyl, tetrazolyl, thiadiazolyl, thiazolyl, oxazolyl, pyrazinyl, and pyrimidinyl.
In another embodiment, R5 is CH2-phenyl substituted with 0-3 R16.

    In another embodiment, R9 is selected from H, CH3, C2-6 alkyl substituted with 0-3 R9a, C3-8 alkenyl, C3-8 alkynyl, C1-3 haloalkyl, (CH2)rC(O)C1-6 alkyl substituted with 0-2 R9j, (CH2)rC(O)OC1-16 alkyl substituted with 0-3 R9b, (CH2)rC(O)NR9dR9d′, (CH2)rS(O)2C1-6 alkyl, S(O)2C1-6 trifluoromethyl, (CH2)rC(O)R9′, (CH2)rC(O)NR9dR9′, (CH2)rS(O)2R9′, R9′, and (CH2)rS(O)2NR9dR9′;
    R9′, at each occurrence, is independently selected from (CHR′)rC3-6 cycloalkyl substituted with 0-3 R9e, wherein the cycloalkyl is selected from cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl, (CHR′)rphenyl substituted with 0-3 R9c, (CHR′)r5-6 membered heterocycle system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R9c, wherein the heterocycle is selected from oxadiazolyl, morpholinyl, piperidinyl, tetrahydropyranyl, tetrahydrothiopyranyl, tetrahydrothiopyranyl dioxide, thiophene, imidazolyl, pyrrolidinyl, pyrrolyl, thiazolyl, and furanyl, and (CHR′)rphenyl substituted with 0-3 R9c;
    R9a, at each occurrence, is selected from CN, O-methyl, O-ethyl, CF3, OH, OC(O)-methyl, S-methyl, S-ethyl, S-propyl, S(O)p-methyl, S(O)p-ethyl, S(O)p-propyl, and NR9dR9d′;
    R9b, at each occurrence, is selected from cyclopropyl, cyclbutyl, cyclpentyl, CN, CF3, CH2—OC1-5 alkyl, CH2—OH, CH2—SC1-5 alkyl, and CH2—NR9dR9d′;
    R9c, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)rC(O)OC1-15 alkyl, (CH2)rC(O)C1-5 alkyl, (CH2)rC(O)NR9dR9d′, (CH2)rOH, (CH2)rSC1-5 alkyl, (CH2)rS(O)pC1-5 alkyl, and (CH2)rNR9dR9d′;
    provided that if R9c is attached to a carbon attached to the nitrogen on Ring B, then R9c is selected from (CH2)qOH, (CH2)qOC1-5 alkyl, (CH2)qSC1-15 alkyl, (CH2)qS(O)qC1-15 alkyl, and (CH2)qNR9dR9d′;
    R9d and R9d′, at each occurrence, are independently selected from H, methyl, ethyl, propyl, i-propyl, butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and phenyl;
    R9e, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)rC(O)OC1-5 alkyl, (CH2)rC(O)NR9dR9d′, (CH2)rOH, (CH2)rSC1-5 alkyl, (CH2)rS(O)pC1-5 alkyl, and (CH2)rNR9dR9d′, or alternatively, two R9e on the same carbon atom form ═O; and
    R9j, at each occurrence, is selected from cyclpropyl, cyclobutyl, cyclopentyl, CN, CF3, O-methyl, O-ethyl, O-propyl, O-i-propyl, O-butyl, OH, S-methyl, S-ethyl, and NR9dR9d′.


In another embodiment, R9 is selected from H, C2-6 alkyl substituted with 0-3 R9a, wherein the alkyl is selected from methyl, ethyl, propyl, i-propyl, butyl, i-butyl, s-butyl, t-butyl, neo-pentyl; —CH2CH═CH2; —CH2C≡CH; 2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, (CH2)rC(O)C1-6 alkyl substituted with 0-2 R9j, wherein the alkyl is selected from methyl, ethyl, propyl, i-propyl, butyl, t-butyl; C(O)Omethyl, C(O)Ot-butyl, SO2methyl, SO2ethyl, SO2propyl, SO2i-propyl, SO2t-butyl, SO2CF3, (CH2)rC(O)NR9dR9d′; (CH2)rC(O)R9′, (CH2)rC(O)NR9dR9′, (CH2)rS(O)2R9′, R9′, and (CH2)rS(O)2NR9dR9;

    R9′, at each occurrence, is independently selected from (CHR′)rC3-6 cycloalkyl, wherein the cycloalkyl is selected from cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl, (CHR′)rphenyl substituted with 0-3 R9c, (CHR′)r5-6 membered heterocycle system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R9c, wherein the heterocycle is selected from oxadiazolyl, morpholinyl, piperidinyl, tetrahydropyranyl, tetrahydrothiopyranyl, tetrahydrothiopyranyl dioxide, thiophene, imidazolyl, pyrrolidinyl, pyrrolyl, thiazolyl, and furanyl, and (CHR′)rphenyl substituted with 0-3 R9c;
    R9a, at each occurrence, is selected from CN, O-methyl, O-ethyl, CF3, OH, OC(O)-methyl, S-methyl, S-ethyl, S-propyl, S(O)p-methyl, S(O)p-ethyl, S(O)p-propyl, and NR9dR9d′;
    R9c, at each occurrence, is selected from methyl, ethyl, propyl, C(O)-methyl, C(O)O-t-butyl;
    R9d and R9d′, at each occurrence, are independently selected from H, methyl, ethyl, propyl, i-propyl, butyl, t-butyl;
    R9j, at each occurrence, is selected from O-methyl, O-ethyl, and NR9dR9d′.


The invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. This invention also encompasses all combinations of preferred aspects of the invention noted herein. It is understood that any and all embodiments of the present invention may be taken in conjunction with any other embodiment to describe additional even more preferred embodiments of the present invention. Furthermore, any elements of an embodiment are meant to be combined with any and all other elements from any of the embodiments to describe additional embodiments.
Definitions
The compounds herein described may have asymmetric centers. Compounds of the present invention containing an asymmetrically substituted atom may be isolated in optically active or racemic forms. It is well known in the art how to prepare optically active forms, such as by resolution of racemic forms or by synthesis from optically active starting materials. Many geometric isomers of olefins, C═N double bonds, and the like can also be present in the compounds described herein, and all such stable isomers are contemplated in the present invention. Cis and trans geometric isomers of the compounds of the present invention are described and may be isolated as a mixture of isomers or as separated isomeric forms. All chiral, diastereomeric, racemic forms and all geometric isomeric forms of a structure are intended, unless the specific stereochemistry or isomeric form is specifically indicated.
The term “substituted,” as used herein, means that any one or more hydrogens on the designated atom is replaced with a selection from the indicated group, provided that the designated atom's normal valency is not exceeded, and that the substitution results in a stable compound. When a substitent is keto (i.e., ═O), then 2 hydrogens on the atom are replaced.
When any variable (e.g., Ra) occurs more than one time in any constituent or formula for a compound, its definition at each occurrence is independent of its definition at every other occurrence. Thus, for example, if a group is shown to be substituted with 0-2 Ra, then said group may optionally be substituted with up to two Ra groups and Ra at each occurrence is selected independently from the definition of Ra. Also, combinations of substituents and/or variables are permissible only if such combinations result in stable compounds.
When a bond to a substituent is shown to cross a bond connecting two atoms in a ring, then such substituent may be bonded to any atom on the ring. When a substituent is listed without indicating the atom via which such substituent is bonded to the rest of the compound of a given formula, then such substituent may be bonded via any atom in such substituent. Combinations of substituents and/or variables are permissible only if such combinations result in stable compounds.
As used herein, “C1-8 alkyl” is intended to include both branched and straight-chain saturated aliphatic hydrocarbon groups having the specified number of carbon atoms, examples of which include, but are not limited to, methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, sec-butyl, t-butyl, pentyl, and hexyl. C1-8 alkyl, is intended to include C1, C2, C3, C4, C5, C6, C7, and C8 alkyl groups. “Alkenyl” is intended to include hydrocarbon chains of either a straight or branched configuration and one or more unsaturated carbon-carbon bonds which may occur in any stable point along the chain, such as ethenyl, propenyl, and the like. “Alkynyl” is intended to include hydrocarbon chains of either a straight or branched configuration and one or more unsaturated triple carbon-carbon bonds which may occur in any stable point along the chain, such as ethynyl, propynyl, and the like. “C3-6 cycloalkyl” is intended to include saturated ring groups having the specified number of carbon atoms in the ring, including mono-, bi-, or poly-cyclic ring systems, such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, and cycloheptyl in the case of C7 cycloalkyl. C3-6 cycloalkyl, is intended to include C3, C4, C5, and C6 cycloalkyl groups
“Halo” or “halogen” as used herein refers to fluoro, chloro, bromo, and iodo; and “haloalkyl” is intended to include both branched and straight-chain saturated aliphatic hydrocarbon groups, for example CF3, having the specified number of carbon atoms, substituted with 1 or more halogen (for example —CvFw where v=1 to 3 and w=1 to (2v+1)).
As used herein, the term “5-6-membered cyclic ketal” is intended to mean 2,2-disubstituted 1,3-dioxolane or 2,2-disubstituted 1,3-dioxane and their derivatives.
As used herein, “carbocycle” or “carbocyclic residue” is intended to mean any stable 3, 4, 5, 6, or 7-membered monocyclic or bicyclic or 7, 8, 9, 10, 11, 12, or 13-membered bicyclic or tricyclic, any of which may be saturated, partially unsaturated, or aromatic. Examples of such carbocycles include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, adamantyl, cyclooctyl, [3.3.0]bicyclooctane, [4.3.0]bicyclononane, [4.4.0]bicyclodecane (decalin), [2.2.2]bicyclooctane, fluorenyl, phenyl, naphthyl, indanyl, adamantyl, or tetrahydronaphthyl (tetralin).
As used herein, the term “heterocycle” or “heterocyclic system” or “heterocyclic ring” is intended to mean a stable 5, 6, or 7-membered monocyclic or bicyclic or 7, 8, 9, or 10-membered bicyclic heterocyclic ring which is saturated, partially unsaturated or unsaturated (aromatic), and which consists of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, NH, O and S and including any bicyclic group in which any of the above-defined heterocyclic rings is fused to a benzene ring. The nitrogen and sulfur heteroatoms may optionally be oxidized. The heterocyclic ring may be attached to its pendant group at any heteroatom or carbon atom which results in a stable structure. The heterocyclic rings described herein may be substituted on carbon or on a nitrogen atom if the resulting compound is stable. If specifically noted, a nitrogen in the heterocycle may optionally be quaternized. It is preferred that when the total number of S and O atoms in the heterocycle exceeds 1, then these heteroatoms are not adjacent to one another. As used herein, the term “aromatic heterocyclic system” is intended to mean a stable 5- to 7-membered monocyclic or bicyclic or 7- to 10-membered bicyclic heterocyclic aromatic ring which consists of carbon atoms and from 1 to 4 heterotams independently selected from the group consisting of N, O and S.
Examples of heterocycles include, but are not limited to, 1H-indazole, 2-pyrrolidonyl, 2H,6H-1,5,2-dithiazinyl, 2H-pyrrolyl, 3H-indolyl, 4-piperidonyl, 4aH-carbazole, 4H-quinolizinyl, 6H-1,2,5-thiadiazinyl, acridinyl, azocinyl, benzimidazolyl, benzofuranyl, benzothiofuranyl, benzothiophenyl, benzoxazolyl, benzthiazolyl, benztriazolyl, benztetrazolyl, benzisoxazolyl, benzisothiazolyl, benzimidazalonyl, carbazolyl, 4aH-carbazolyl, β-carbolinyl, chromanyl, chromenyl, cinnolinyl, decahydroquinolinyl, 2H,6H-1,5,2-dithiazinyl, dihydrofuran-2-one, dihydrofuro[2,3-b]tetrahydrofuran, furanyl, furazanyl, imidazolidinyl, imidazolinyl, imidazolyl, 1H-indazolyl, indolenyl, indolinyl, indolizinyl, indolyl, isobenzofuranyl, isochromanyl, isoindazolyl, isoindolinyl, isoindolyl, isoquinolinyl (benzimidazolyl), isothiazolidine 1,1-dioxide, isothiazolyl, isoxazolyl, morpholinyl, naphthyridinyl, octahydroisoquinolinyl, oxadiazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl, 1,3,4-oxadiazolyl, oxazolidinyl, oxazolyl, oxazolidinylperimidinyl, phenanthridinyl, phenanthrolinyl, phenarsazinyl, phenazinyl, phenothiazinyl, phenoxathiinyl, phenoxazinyl, phthalazinyl, piperazinyl, piperidin-2-one, piperidinyl, pteridinyl, piperidonyl, 4-piperidonyl, pteridinyl, purinyl, pyranyl, pyrazinyl, pyrazolidinyl, pyrazolinyl, pyrazolyl, pyridazinyl, pyridooxazole, pyridoimidazole, pyridothiazole, pyridinyl, pyridyl, pyrimidinyl, pyrrolidin-2-one, pyrrolidinyl, pyrrolinyl, pyrrolyl, quinazolinyl, quinolinyl, 4H-quinolizinyl, quinoxalinyl, quinuclidinyl, carbolinyl, tetrahydrofuranyl, tetrahydroisoquinolinyl, tetrahydropyranyl (THP), tetrahydroquinolinyl, tetrahydropyran-2-one, tetrahydrothiophenyl, 1-oxo-hexahydro-1λ4-thiopyranyl, 1,1-dioxo-hexahydro-1λ6-thiopyranyl, tetrahydrothiopyranyl (THTP), 6H-1,2,5-thiadiazinyl, 1,2,3-thiadiazolyl, 1,2,4-thiadiazolyl, 1,2,5-thiadiazolyl, 1,3,4-thiadiazolyl, thianthrenyl, 1,1-dioxo-1λ6-[1,2]thiazinanyl, thiazolyl, thienyl, thienothiazolyl, thienooxazolyl, thienoimidazolyl, thiophenyl, triazinyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,5-triazolyl, 1,3,4-triazolyl, tetrazolyl, and xanthenyl. Preferred heterocycles include, but are not limited to, pyridinyl, thiophenyl, furanyl, indazolyl, benzothiazolyl, benzimidazolyl, benzothiaphenyl, benzofuranyl, benzoxazolyl, benzisoxazolyl, quinolinyl, isoquinolinyl, imidazolyl, indolyl, isoidolyl, piperidinyl, piperidonyl, 4-piperidonyl, piperonyl, pyrrazolyl, 1,2,4-triazolyl, 1,2,3-triazolyl, tetrazolyl, thiazolyl, oxazolyl, pyrazinyl, pyrimidinyl, tetrahydropyranyl, tetrahydrothiopyranyl, 1-oxo-hexahydro-1λ4-thiopyranyl, 1,1-dioxo-hexahydro-1λ6-thiopyranyl, piperidin-2-one, tetrahydropyran-2-one, 1,1-dioxo-1λ6-[1,2]thiazinanyl, pyrrolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, pyrrolidin-2-one, dihydrofuran-2-one, and isothiazolidine 1,1-dioxide. Also included are fused ring and spiro compounds containing, for example, the above heterocycles.
The phrase “pharmaceutically acceptable” is employed herein to refer to those compounds, materials, compositions, and/or dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals without excessive toxicity, irritation, allergic response, or other problem or complication, commensurate with a reasonable benefit/risk ratio.
As used herein, “pharmaceutically acceptable salts” refer to derivatives of the disclosed compounds wherein the parent compound is modified by making acid or base salts thereof. Examples of pharmaceutically acceptable salts include, but are not limited to, mineral or organic acid salts of basic residues such as amines; alkali or organic salts of acidic residues such as carboxylic acids; and the like. The pharmaceutically acceptable salts include the conventional non-toxic salts or the quaternary ammonium salts of the parent compound formed, for example, from non-toxic inorganic or organic acids. For example, such conventional non-toxic salts include those derived from inorganic acids such as hydrochloric, hydrobromic, sulfuric, sulfamic, phosphoric, nitric and the like; and the salts prepared from organic acids such as acetic, propionic, succinic, glycolic, stearic, lactic, malic, tartaric, citric, ascorbic, pamoic, maleic, hydroxymaleic, phenylacetic, glutamic, benzoic, salicylic, sulfanilic, 2-acetoxybenzoic, fumaric, toluenesulfonic, methanesulfonic, ethane disulfonic, oxalic, isethionic, and the like.
The pharmaceutically acceptable salts of the present invention can be synthesized from the parent compound which contains a basic or acidic moiety by conventional chemical methods. Generally, such salts can be prepared by reacting the free acid or base forms of these compounds with a stoichiometric amount of the appropriate base or acid in water or in an organic solvent, or in a mixture of the two; generally, nonaqueous media like ether, ethyl acetate, ethanol, isopropanol, or acetonitrile are preferred. Lists of suitable salts are found in Remington's Pharmaceutical Sciences, 17th ed., Mack Publishing Company, Easton, Pa., 1985, p. 1418, the disclosure of which is hereby incorporated by reference.
Since prodrugs are known to enhance numerous desirable qualities of pharmaceuticals (e.g., solubility, bioavailability, manufacturing, etc . . . ) the compounds of the present invention may be delivered in prodrug form. Thus, the present invention is intended to cover prodrugs of the presently claimed compounds, methods of delivering the same and compositions containing the same. “Prodrugs” are intended to include any covalently bonded carriers which release an active parent drug of the present invention in vivo when such prodrug is administered to a mammalian subject. Prodrugs the present invention are prepared by modifying functional groups present in the compound in such a way that the modifications are cleaved, either in routine manipulation or in vivo, to the parent compound. Prodrugs include compounds of the present invention wherein a hydroxy, amino, or sulfhydryl group is bonded to any group that, when the prodrug of the present invention is administered to a mammalian subject, it cleaves to form a free hydroxyl, free amino, or free sulfhydryl group, respectively. Examples of prodrugs include, but are not limited to, acetate, formate and benzoate derivatives of alcohol and amine functional groups in the compounds of the present invention.
As used herein, “treating” or “treatment” cover the treatment of a disease-state in a mammal, particularly in a human, and include: (a) preventing the disease-state from occurring in a mammal, in particular, when such mammal is predisposed to the disease-state but has not yet been diagnosed as having it; (b) inhibiting the disease-state, i.e., arresting it development; and/or (c) relieving the disease-state, i.e., causing regression of the disease state.
“Stable compound” and “stable structure” are meant to indicate a compound that is sufficiently robust to survive isolation to a useful degree of purity from a reaction mixture, and formulation into an efficacious therapeutic agent.
Synthesis
The compounds of Formula I can be prepared using the reactions and techniques described below. The reactions are performed in a solvent appropriate to the reagents and materials employed and suitable for the transformations being effected. It will be understood by those skilled in the art of organic synthesis that the functionality present on the molecule should be consistent with the transformations proposed. This will sometimes require a judgment to modify the order of the synthetic steps or to select one particular process scheme over another in order to obtain a desired compound of the invention. It will also be recognized that another major consideration in the planning of any synthetic route in this field is the judicious choice of the protecting group used for protection of the reactive functional groups present in the compounds described in this invention. An authoritative account describing the many alternatives to the trained practitioner is Greene and Wuts (Protective Groups In Organic Synthesis, Wiley and Sons, 1999).
Generally, compounds described in the scope of this patent application can be synthesized by the route described in Schemes 1, 2 or 3. In all schemes, P is a suitable protecting group as described in Greene and Wuts, Protective Groups in Organic Synthesis, 3rd edition, John Wiley & Sons, New York. In Scheme 1, the appropriately substituted pyrrolidine (n=0) or piperidine (n=1) 1 is alkylated by a N-protected alkylhalide (halide=Cl, Br, I), mesylate, tosylate or triflate, 2, (where E represents a linkage described within the scope of this application in its fully elaborated form with the appropriate protecting groups as understood by one skilled in the art or in a precursor form which can be later elaborated into its final form by methods familiar to one skilled in the art) with or without base or an acid scavenger to yield the piperidinyl- or pyrrolidinylalkyl protected amine 3. If the halide is not I, then KI can also be added to facilitate the displacement, provided the solvent is suitable, such as an alcohol, 2-butanone, DMF or DMSO, amongst others. The displacement can be performed at room temperature to the reflux temperature of the solvent. The protecting group is subsequently removed to yield amine 4. Protecting groups include phthalimide which can be removed by hydrazine, a reaction familiar to one skilled in the art; bis-BOC which can be removed by either TFA or HCl dissolved in a suitable solvent, both procedures being familiar to one skilled in the art; a nitro group instead of an amine which can be reduced to yield an amine by conditions familiar to one skilled in the art; 2,4-dimethyl pyrrole (S. P. Breukelman, et al. J. Chem. Soc. Perkin Trans. I,1984, 2801); N-1,1,4,4-Tetramethyl-disilylazacyclopentane (STABASE) (S. Djuric, J. Venit, and P. Magnus Tet. Lett 1981, 22, 1787) and other protecting groups. Reaction with an isocyanate or isothiocyanate 5 (Z=O,S) yields urea or thiourea 6. Reaction with a chloroformate or chlorothioformate 7 (Z=O,S) such as o-, p-nitrophenyl-chloroformate or phenylchloroformate (or their thiocarbonyl equivalents), followed by displacement with an amine 9, also yields the corresponding urea or thiourea 6. Likewise, reaction of carbamate 8 (X═H, or 2- or 4-NO2) with disubstituted amine 10 yields trisubstituted urea or thiourea 12. Reaction of the amine 4 with an N,N-disubstituted carbamoyl chloride 11 (or its thiocarbonyl equivalent) yields the corresponding N,N-disubstituted urea or thiourea 12. Amine 4 can also be reductively aminated with aldehyde 13 to yield 14 by conditions familiar to one skilled in the art and by the following conditions: Abdel-Magid, A. F., et al. Tet. Lett. 1990, 31, (39) 5595-5598. This secondary amine can subsequently be reacted with isocyanates or isothiocyanates to yield trisubstituted ureas 15 or with carbamoyl chlorides to yield tetrasubstituted ureas 16. 




One can also convert amine 4 into an isocyanate, isothiocyanate, carbamoyl chloride or its thiocarbonyl equivalent (isocyanate: Nowakowski, J. J Prakt. Chem/Chem-Ztg 1996, 338 (7), 667-671; Knoelker, H.-J. et al., Angew. Chem. 1995, 107 (22), 2746-2749; Nowick, J. S. et al., J. Org. Chem. 1996, 61 (11), 3929-3934; Staab, H. A.; Benz, W.; Angew Chem 1961, 73; isothiocyanate: Strekowski L. et al., J. Heterocycl. Chem. 1996, 33 (6), 1685-1688; Kutschy, Pet al., Synlett. 1997, (3), 289-290) carbamoyl chloride: Hintze, F.; Hoppe, D.; Synthesis (1992) 12, 1216-1218; thiocarbamoyl chloride: Ried, W.; Hillenbrand, H.; Oertel, G.; Justus Liebigs Ann Chem 1954, 590) (these reactions are not shown in Scheme 1). These isocyanates, isothiocyanates, carbamoyl chlorides or thiocarbamoyl chlorides can then be reacted with R2R3NH to yield di- or trisubstituted ureas or thioureas 12. An additional urea forming reaction involves the reaction of carbonyldiimidazole (CDI) (Romine, J. L.; Martin, S. W.; Meanwell, N. A.; Epperson, J. R.; Synthesis 1994 (8), 846-850) with 4 followed by reaction of the intermediate imidazolide with 9 or in the reversed sequence (9+CDI, followed by 4). Activation of imidazolide intermediates also facilitates urea formation (Bailey, R. A., et al., Tet. Lett. 1998, 39, 6267-6270). One can also use 14 and 10 with CDI. The urea forming reactions are done in an aprotic inert solvent such as THF, toluene, DMF, etc., at room temperature to the reflux temperature of the solvent and can employ the use of an acid scavenger or base when necessary such as carbonate and bicarbonate salts, triethylamine, DBU, Hunig's base, DMAP, etc.
Scheme 2 describes the synthesis of compounds with an carbonyl linking the appropriately substituted pyrrolidine (n=0) or piperidine (n=1) 1 and B. When carboxylic acid 17 is used, a wide variety of dehydrating coupling reagents may be used to prepare the amide 198 from amine 1. A review of the possible reaction conditions was prepared by Y. S. Klausner and M. Bodansky in Synthesis 1972, 9, 453-463. Additional references by E. Gross and J. Meienhofer can be found in the monograph series The Peptides, 4 vols.; Academic Press: New York, 1979-1983. Alternatively the acid chloride 18 can be prepared from carboxylic acid 17 via thionyl chloride or oxalyl chloride among other reagents (see Ansell in S. Patai, The Chemistry of Carboxylic Acids and Esters, Wiley Interscience: New York 1969, 35-68) and then coupled with amine 1 to give amide 19. Deprotection of amide 19 gives the required intermediate amine 20, which can be further elaborated to the final products by the procedures outlined in Scheme 1. 




An alternative coupling of a alkyl linkage to the appropriately substituted pyrrolidine (n=0) or piperidine (n=1) 1 and B uses an reductive amination sequence (Abdel-Magid, A. F., et al. Tet. Lett. 1990, 31, (39) 5595-5598) shown in Scheme 3. The appropriately protected aldehyde 21 is reacted with amine 1 and the resulting imine is reduced with sodium triacetoxy-borohyride. Alternative hydride sources such as sodium cyanoborohydride may also be used. Deprotection of protected amine 22 gives the required intermediate amine 23, which can be further elaborated to the final products by the procedures outlined in Scheme 1. 




Substituted pyrrolidines and piperidines 1 can either be obtained commercially or be prepared as shown in the example of Scheme 4. Commercially available N-benzylpiperid-3-one 24 can be debenzylated and protected with a BOC group employing reactions familiar to one skilled in the art. Subsequent Wittig reaction followed by reduction and deprotection yields piperidine 28 employing reactions familiar to one skilled in the art. Substituted pyrrolidines may be made by a similar reaction sequence. Other isomers and analogs around the piperidine ring can also be made by a similar reaction sequence. Chiral pyrrolidines/piperidines can be synthesized via asymmetric hydrogenation of 18 using chiral catalysts (see Parshall, G. W. Homogeneous Catalysis, John Wiley and Sons, New York: 1980, pp. 43-45; Collman, J. P., Hegedus, L. S. Principles and Applications of Organotransition Metal Chemistry, University Science Books, Mill Valley, Calif., 1980, pp. 341-348). 




Guanidines (Z=NR1a) can be synthesized by the methods outlined in Scheme 5. Compound 29 where Z=S can be methylated to yield the methylisothiourea 30. Displacement of the SMe group with amines yields substituted guanidines 31 (see H. King and I. M. Tonkin J. Chem. Soc. 1946, 1063 and references therein). Alternatively, reaction of thiourea 29 with amines in the presence of triethanolamine and “lac sulfur” which facilitates the removal of H2S yields substituted guanidines 31 (K. Ramadas, Tet. Lett. 1996, 37, 5161 and references therein). Finally, the use of carbonimidoyldichloride 32, or 33 followed by sequential displacements by amines yields the corresponding substituted guanidine 31 (S. Nagarajan, et al., Syn. Comm. 1992, 22, 1191-8 and references therein). In a similar manner, carbonimidoyldichlorides, R2—N═C(Cl)2 (not shown in Scheme 5) and R3—N═C(Cl)2 (not shown) can also be reacted sequentially with amines to yield di- and trisubstituted guanidine 23. 




Schemes 6 through 30 and Scheme 43 describe the syntheses of the variety of heterocyclic linkers, B. The protecting groups shown in the following schemes were chosen to maximize the utility of intermediates in a variety of schemes and may be interchanged with other compatible groups. While the synthesis of only one enantiomer is shown, the chiral precursors are available in both forms and therefore any isomer can be made from commercially available starting materials.
Scheme 6 describes the preparation of 2,3-disubstituted piperidines. The aspartic acid 34 can be exhaustively protected with benzyl bromide and the beta-carbon can be alkylated with allyl bromide to give the amino ester 35 as a mixture of diastereomers. Hydroboration can provide the alcohol 36 (H. C. Brown, J. C. Chen; J. Org. Chem. 1981, 46, 3978), with can be oxidized to an aldehyde (K. Omura, D. Swerm; Tet. Lett. 1978, 34, 1651) and the benzyl groups removed by catalytic hydrogenation. The intermediate aminoaldehyde cyclizes to an imine which can be further reduced to an aminoacid. Coupling this aminoacid with BOP—Cl (Castro, B.; Dormoy, J. R.; Evin, G.; Selve, C. Tet. Lett. 1975, 14, 1219) and the corresponding cyclic amine can give amide 37. Acidic hydrolysis of the ester, Boc protection of the amine, Curtius rearrangement via dppa (Deng, J.; Hamada, Y.; Shioiri, T. Tet. Lett. 1996, 37, 2261) can provide the amine 38. To prepare the methylene derivative, borane reduction of amine 38 can give amine 39. 




For the synthesis of 3,4-disubstituted piperidines, the sequence shown in Scheme 7 can be used. Following a procedure using an analog of a cyclohexanone derivative (Hayashi, Y.; Rohde, J. J.; Corey, E. J. J. Am. Chem. Soc. 1996, 118(23), 5502), the imine of 4-ketopiperidine 40 can be prepared by heating with (R)-alpha-methyl benzylamine with Dean-Stark trapping. Reduction with sodium triacetoxyborohyride can give the cis-amino ester 42. Epimerization can give the trans derivative 43. Hydrogenolysis of the benzyl group and protection as a benzyl carbamate 44 can provide a common intermediate for the hydrolysis and coupling to prepare amide 45 after deprotection. Alternatively, the ester can reduced to an alcohol, oxidized to an aldehyde, reductively aminated and deprotected to give amine 46. 




In a very similar manner, ketopiperidine 47 can be converted to amide 52 or amine 53 as shown in Scheme 8. 




The synthesis of 2,3-disubstituted dihydropyrans is described in Scheme 9. Starting with diol 54, mono-protection and oxidation (Siedlecka, R.; Skarzewski, J. k; Mlochowski, J.; Tet. Lett. 1990, 31(15), 2177) can give acid 55. Acylation of the chiral auxiliary mediated by pivaloyl chloride can give oxazolinone 57. Sparteine-mediated aldol condensation with cinnamaldehyde sets up the required stereochemistry in alcohol 58 (Crimmins, M. T.; King, B. W.; Tabet, E. A.; J. Am. Chem. Soc. 1997, 119(33), 7883). Fluoride deprotection, triflate-mediated cyclization and lithium peroxide removal of the auxiliary can provide dihydropyran 59. Curtius rearrangement in the presence of t-butanol can produce the required protected amine. Oxidation with ozone and quenching with dimethyl sulfide can give the aldehyde 61. Oxidation of aldehyde 61 with TEMPO can give carboxylic acid 60. 




Scheme 10 describes the synthesis of 3,4-disubstituted dihydropyrans. Coupling of oxazolinone 56 with cinnamoyl chloride and subsequent boron-mediated aldol condensation (Galatsis, P.; Millan, S. D.; Ferguson, G.; J. Org. Chem. 1997, 62(15), 5048) with aldehyde 62 can give alcohol 63. Lithium borohydride auxiliary removal, protection of the primary alcohol with TBSCl, mesylate formation of the secondary alcohol, displacement of the mesylate with azide and reduction of the azide and protection of the resulting amine can give 64. Ozonolysis followed by reductive workup, mesylate formation of the alcohol, selective fluoride deprotection of the TBMP silyl ether (Guindon, Y.; Fortin, R.; Yaokim, C.; Gillard, J. W.; Tet. Lett. 1984, 25, 4717), and basic cyclization can provide dihydropyran 65. Fluoride deprotection followed by Swern oxidation can produce aldehyde 66 for reductive amination. Alternatively, the alcohol can be oxidized with PDC (Corey, E. J.; Schmidt, G. Tet. Lett. 1979, 5, 399) to acid 67. 




The preparation of the regioisomeric 3,4-disubstituted dihydropyrans is shown in Scheme 11. One of the key differences between Schemes 11 and 10 is the aldol reaction with the shorter chain aldehyde 68. Instead of ozonolysis, the olefin 70 can be hydroborated, the resulting alcohol can be mesylated, and, after deprotection, undergoes ring closure to give the desired dihydropyran 71. Oxidation can give either 72 or 73. 




For the corresponding dihydrothiopyrans, advanced precursors from the dihydropyran syntheses were used. Scheme 12 describes the synthesis of 2,3-disubstituted dihydrothiopyrans. Starting with alcohol 58, Lawesson's reagent displaces the hydroxyl with retention of configuration (Eberle, M. K.; Nuninger, F.; Weber, H-P.; J. Org. Chem. 1995, 60(8), 2610). Acidic fluoride deprotection removes the silyl group and catalyzes the cyclization to the dihydrothiopyran. Lithium hydroperoxide removes the chiral auxiliary and oxidizes the sulfur to the sulfone 74. Curtius rearrangement with Boc anhydride and ozonolysis with oxidative workup can give acid 75. Ozonolysis with reductive workup can give aldehyde 76. 




The preparation of the regioisomeric dihydro-thiopyrans can be shown in Scheme 13. Ozonolysis of olefin 64 with reductive workup can provide an alcohol. Selective fluoride deprotection of the TBMP silyl group (discussed with scheme 10), mesylate formation on both alcohols, followed by displacement with sodium sulfide and subsequent ring closure can give sulfide 77. Fluoride deprotection and Swern oxidation can give aldehyde 78. Alternatively, PDC oxidation (Jeong, L. S.; Schinazi, R. F.; Beach, J. W.; Kim, H. O.; Shanmuganathan, K.; J. Med. Chem. 1993, 36(18), 2627) can give acid 79. 




The preparation of the other regioisomeric dihydro-thiopyrans can be shown in Scheme 14. Selective fluoride deprotection of the TBMP silyl group on 70 (discussed previously), mesylate formation, can be followed by displacement of the mesylate with sodium sulfide. Reduction of the olefin initiates ring closure to give sulfide 80 (Aggarwal, V. K.; Ford, J. G.; Fonquerna, S.; Adams, H.; Jones, R. V. H.; Fieldhouse, R.; J. Am. Chem. Soc. 1998, 120, 30). Fluoride deprotection and Swern oxidation can give aldehyde 81. Alternatively, PDC oxidation can give acid 82. 




Scheme 15 shows the synthesis of the 5,6-disubstituted lactams. Alcohol 36 can be oxidized with PDC to the carboxylic acid, the ester and amine are deprotected by hydrogenolysis, heat can be applied to do a intramolecular cyclization, and the remaining carboxylic acid can be coupled with BOP—Cl with the amine 1 to give amide 83. Acidic ester hydrolysis with trifluoroacetic acid followed by Curtius rearrangement with dppa can provide amine 84. 




If the methylene linker can be desired for the 5,6-disubstituted lactams, then the synthesis can be outlined in Scheme 16. Alcohol 36 can be oxidized with PDC to the carboxylic acid, the ester and amine are deprotected by hydrogenolysis, heat can be applied to do a intramolecular cyclization, and the remaining carboxylic acid can be converted to the acid chloride, reduced to the alcohol and protected with the TBDP silyl group to give ester 85. Acidic ester hydrolysis with trifluoroacetic acid, Curtius rearrangement with dppa and Boc protection of the amine, fluoride deprotection and Swern oxidation can provide aldehyde 86. 




Scheme 17 describes the synthesis of 3,4-disubstituted lactams. Olefin 64 can be ozonolyzed with an oxidative workup. The resulting carboxylic acid can be converted to methyl ester 87 with trimethylsilyl diazomethane. Selective fluoride deprotection, mesylate formation, azide displacement of the mesylate, reduction of the azide and concomitant cyclization onto the ester can provide amide 88. Fluoride deprotection and Swern oxidation completes the synthesis of aldehyde 89. 




Scheme 18 describes the synthesis of 4,5-disubstituted lactams. Ether 64 can be selectively deprotected, oxidized to a carboxylic acid and esterified with trimethylsilyl diazomethane to give ester 90. Ozonolysis of the olefin with reductive workup, followed by mesylate formation of the resulting alcohol, azide displacement of the mesylate, reduction of the azide and concomitant cyclization onto the ester can provide amide 91. Fluoride deprotection and Swern oxidation completes the synthesis of aldehyde 92. Alternatively, oxidation with PDC can give acid 93. 




Scheme 19 describes the synthesis of regioisomeric 4,5-disubstituted lactams. Olefin 70 can be hydroborated, the resulting alcohol can be oxidized to a carboxylic acid and esterified with trimethylsilyl diazomethane to give ester 94. Selective fluoride deprotection, followed by mesylate formation of the resulting alcohol, azide displacement of the mesylate, reduction of the azide and concomitant cyclization onto the ester can provide amide 95. Fluoride deprotection and Swern oxidation completes the synthesis of aldehyde 96. Alternatively, oxidation with PDC can give acid 97. 




Scheme 20 describes the synthesis of regioisomeric 2,3-disubstituted lactams. Ether 70 can be selectively deprotected, the resulting alcohol can be oxidized to a carboxylic acid and esterified with trimethylsilyl diazomethane to give ester 98. Hydroboration, followed by mesylate formation of the resulting alcohol, azide displacement of the mesylate, reduction of the azide and concomitant cyclization onto the ester can provide amide 99. Fluoride deprotection and Swern oxidation completes the synthesis of aldehyde 100. Alternatively, oxidation with PDC can give acid 101. 




The corresponding lactones are prepared in a series of synthetic schemes that parallel those used to prepare the corresponding lactams. The synthesis of 5,6-disubstituted lactones is described in Scheme 21. Starting with ether 58, fluoride deprotection, selective oxidation of the primary alcohol with quinolinium chlorochromate (Singh, J.; Kalsi, Partap S.; Jawanda, G. S.; Chhabra, B. R.; Chem. Ind. 1986, 21, 751), further oxidation of the resulting aldehyde with silver(II) oxide (Corey, E. J.; Gilman, N. W.; Ganem, B. E.; J. Amer. Chem. Soc. 1968, 90(20), 5616), heating to facilitate cyclization, and lithium peroxide cleavage of the auxiliary can provide lactone 102. Curtius rearrangement followed by ozonolysis with a reductive workup give aldehyde 103. Alternatively, an oxidative workup can give acid 104. 




Scheme 22 describes the synthesis of 3,4-disubstituted lactones. Olefin 64 can be ozonolyzed with an oxidative workup. The TBMP silyl group can be selectively removed with fluoride, the alcohol can be heated and cyclizes with the carboxylic acid to give the lactone 105. Fluoride deprotection and Swern oxidation completes the synthesis of aldehyde 106. 




Scheme 23 describes the synthesis of 3,4-disubstituted lactones. The TBMP silyl group of ether 64 can be selectively removed with fluoride, the alcohol can be oxidized with PDC to a carboxylic acid, and the olefin can be ozonolyzed with an reductive workup to facilitate closure to the lactone 107. Fluoride deprotection and Swern oxidation completes the synthesis of aldehyde 108. Alternately, the alcohol can be oxidized with PDC to the carboxylic acid 109. 




Scheme 24 describes the synthesis of regioisomeric 4,5-disubstituted lactones. Olefin 70 can be hydroborated, the resulting alcohol can be oxidized to a carboxylic acid, the TBMP silyl can be selectively deprotected, and heated to promote cyclization to give amide 110. Fluoride deprotection and Swern oxidation completes the synthesis of aldehyde 111. Alternatively, oxidation with PDC can give acid 112. 




Scheme 25 describes the synthesis of regioisomeric 3,4-disubstituted lactones. The TBMP silyl group of ether 70 can be selectively removed with fluoride, the alcohol can be oxidized with PDC to a carboxylic acid, and the olefin can be hydroborated and heated to facilitate closure to the lactone 113. Fluoride deprotection and Swern oxidation completes the synthesis of aldehyde 114. Alternately, the alcohol can be oxidized with PDC to the carboxylic acid 115. 




Scheme 26 shows the synthesis of the 5,6-disubstituted sulfonamides. Alcohol 36 can be converted to the thiol with Lawesson's reagent (Nishio, T.; J. Org. Chem. 1997, 62(4), 1106), the thiol can be oxidized with performic acid (Roberts, d. V.; J. biol. Chem. 1953, 204, 871), the benzyl groups were hydrogenolyzed and the mixture heated to facilitate cyclization to sulfonamide 116 (Selve, C.; Neiedercorn, F.; Nacro, M.; Castro, B.; Gabriel, M.; Tetrahedron 1981, 37, 1903). The carboxylic acid can be converted to the acid chloride with oxalyl chloride, reduced with sodium borohyride, and protected as a TBDP silyl ether 117. Acidic ester hydrolysis, Curtius rearrangement with dppa, fluoride deprotection, followed by Swern oxidation can provide aldehyde 118. Alternately, the alcohol can be oxidized with PDC to the carboxylic acid 119. 




Scheme 27 describes the synthesis of 3,4-disubstituted sulfonamides. The olefin 64 can be ozonolyzed with reductive workup, the resulting alcohol can be converted to a thiol, and then oxidized to the sulfonic acid 120. Selective fluoride deprotection, mesylate formation, azide displacement and hydrogenation followed by cyclization can provide sulfonamide 121. Fluoride deprotection and Swern oxidation can give aldehyde 122. 




Scheme 28 describes the synthesis of 4,5-disubstituted sulfonamides. The ether 64 can be selectively fluoride deprotected, the resulting alcohol can be converted to a thiol, and then oxidized to the sulfonic acid 123. Ozonolysis with reductive workup, mesylate formation, azide displacement and hydrogenation followed by cyclization can provide sulfonamide 124. Fluoride deprotection and Swern oxidation can give aldehyde 125. Alternately, the alcohol can be oxidized with PDC to the carboxylic acid 126. 




Scheme 29 describes the synthesis of 4,5-disubstituted sulfonamides. The olefin 64 can be hydroborated, the resulting alcohol can be converted to a thiol, and then oxidized to the sulfonic acid 127. Selective fluoride deprotection, mesylate formation, azide displacement and hydrogenation followed by cyclization can provide sulfonamide 128. Fluoride deprotection and Swern oxidation can give aldehyde 129. Alternately, the alcohol can be oxidized with PDC to the carboxylic acid 130. 




Scheme 30 describes the synthesis of 4,5-disubstituted sulfonamides. The ether 70 can be selectively fluoride deprotected, the resulting alcohol can be converted to a thiol, and then oxidized to the sulfonic acid 131. Hydroboration of the olefin, mesylate formation, azide displacement and hydrogenation followed by cyclization can provide sulfonamide 132. Fluoride deprotection and Swern oxidation can give aldehyde 133. Alternately, the alcohol can be oxidized with PDC to the carboxylic acid 134. 




Multisubstituted pyrrolidines and piperidines may be synthesized by the methods outlined in Scheme 31. Monoalkylation of 135 via an enolate using LDA or potassium hexamethyldisilazane, or converting 135 first to an enamine, or by using other bases, all of which can be done in THF, ether, dioxane, benzene, or an appropriate non-hydroxylic solvent at −78° C. to room temperature with an alkylating agent such as methyl iodide, benzyl bromide, etc. where X can be as defined in Scheme 1, yields product 136. This product can subsequently undergo alkylation again under thermodynamic or kinetic conditions and afterwards, if need be, can undergo two more alkylations to produce tri- and tetrasubstituted analogs of 136. The thermodynamic or kinetic conditions yield regioselectively alkylated products (for a discussion on thermodynamic vs. kinetic alkylations see H. House Modern Synthetic Reactions, W. A. Benjamin, Inc. (Menlo Park, Calif.: 1972) chapter 9). 




Subsequent Wittig olefination yields compound 137. Hydrogenation (asymmetric hydrogenation can be an option here: Parshall, G. W. Homogeneous Catalysis, John Wiley and Sons, New York: 1980, pp. 43-45; Collman, J. P., Hegedus, L. S. Principles and Applications of Organotransition Metal Chemistry, University Science Books, Mill Valley, Calif., 1980, pp. 341-348) yields pyrrolidine or piperidine 138 which can be resolved into its relative and/or absolute isomers at this stage or later on in the synthesis either by crystallization, chromatographic techniques, or other methods familiar to one skilled in the art. The amine 138 an then be elaborated into the compounds of this invention by methods discussed previously (Scheme 1). The carbonyl-containing intermediate 136 in Scheme 31 can also be reduced to the methylene analog via a Wolff-Kishner reduction and modifications thereof, or by other methods familiar to one skilled in the art. This piperidine or pyrrolidine can be deprotected and elaborated to the compounds of this invention by methods discussed earlier. Thus, mono-, di-, tri-, or tetraalkylated carbonyl-containing pyrrolidines or piperidines can be synthesized, which in turn can be reduced to the corresponding —CH2— analogs employing the Wolff-Kishner reduction or other methods.

Another method for synthesizing gem-substituted pyrrolidines and piperidines can be shown in Scheme 32. It can be understood by one skilled in the art that some of the steps in this scheme can be rearranged. It can be also understood that gem-disubstitution can be only shown at only one position on the piperidine ring and that similar transformations may be performed on other carbon atoms as well, both for piperidine and pyrrolidine. Thus, 3-carboethoxypiperidine 139 may be BOC-protected and alkylated employing a base such as LDA, KHMDS, LHDMS, etc., in THF, ether, dioxane, etc. at −78° C. to room temperature, and an alkylating agent R6X where X can be a halide (halide=Cl, Br, I), mesylate, tosylate or triflate, to yield 141. Reduction using DIBAL, for example, and if necessary followed by oxidation such as a Swern oxidation (S. L. Huang, K. Omura, D. Swern J. Org. Chem. 1976, 41, 3329-32) yields aldehyde 142. Wittig olefination (143) followed by deprotection yields 144 which may be elaborated as described previously into the compounds of this invention. Reduction of the Wittig adduct 143 yields 145 which may be deprotected to yield 146 which may be in turn elaborated as described previously into the compounds of this invention. Reaction of aldehyde 142 with an alkyllithium or Grignard reagent yields alcohol 147 which may be reduced catalytically or with Et3SiH/TFA (J. Org. Chem. 1969, 34, 4; J. Org. Chem. 1987, 52, 2226) if R5* (R5*═R5 or a precursor thereof) can be aromatic to yield 148. If R5* can be not aromatic, then the OH may be reduced by the method of Barton (Barton, D. H. R.; Jaszberenyi, J. C. Tet. Lett. 1989, 30, 2619 and other references therein). Once tosylated, the alcohol can also be displaced with dialkyllithium cuprates (not shown) (Hanessian, S.; Thavonekham, B.; DeHoff, B.; J Org. Chem. 1989, 54, 5831). Deprotection if necessary yields 149 which may be elaborated as described previously into the compounds of this invention. 




A method for the alkylation of alkyl groups, arylalkyl groups, allylic groups, propargylic groups, etc., and a variety of other electrophiles onto the pyrrolidinyl and/or piperidinyl alpha-carbons (alpha to the ring nitrogen atom) can be represented by the work of Peter Beak, et al. as shown in Scheme 33. It can be understood by one skilled in the art that the R5 and R13 groups are either in their precursor, protected, or final form. Only one R5 group can be shown to be substituted on piperidine/pyrrolidine 150. However it can be understood by one skilled in the art that additional functionality may be present on the ring in either precursor, protected, or final form. Thus lithiation with an alkyllithium reagent such as n-BuLi or s-BuLi as shown, followed by quenching with an electrophilic species such as R5X or R13X where X can be as defined in Scheme 1 and R5 and R13 are in their precursor, protected, or final form, yields monoalkylated piperidine/pyrrolidine 151. This alkylation may occur either stereoselectively (P. Beak and W. K. Lee J. Org. Chem. 1990, 55, 2578-2580) or enantioselectively if sparteine can be included as a source of chirality (P. Beak, et al., J. Am. Chem. Soc. 1994, 116, 3231-3239). The alkylation process may be repeated up to three more times as shown in Scheme 33 to result in di-, tri-, and tetrasubstitution at the alpha-positions. 




A method for the synthesis of N-substituted heterocycles at R5 can be shown in Scheme 34. The heterocycle can be deprotonated with NaH or by other bases familiar to one skilled in the art, in a solvent such as DMF, THF, or another appropriate non-hydroxylic solvent and reacted with piperidine or pyrrolidine 155 at room temperature to the reflux temperature of the solvent. Deprotection and elaboration as described before yields compounds where R5 contains an N-substituted heterocycle. If the nitrogen atom of the heterocycle can be sufficiently nucleophilic, then an acid scavenger, such as K2CO3, KHCO3, Na2CO3, NaHCO3, amongst others, can be used in place of NaH, employing THF, DMF, or methyl ethyl ketone as solvents. In this case hydroxylic solvents may be used as well, such as methanol, ethanol, etc. from room temperature to the reflux temperature of the solvent. Compound 155 as well as its other positional isomers are available, for example, from commercially available 4-hydroxymethylpiperidine, 2-, 3-, and 4-carboethoxypiperidine, L- or D-proline ethyl ester, or from methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate by methods familiar to one skilled in the art and as discussed previously in this application. 




A method for the synthesis of C-substituted heterocycles at R5 can be shown in Scheme 35. Many heterocycles such as the ones shown in Scheme 35, but not limited thereto, can be metallated with strong bases such as LDA, n-BuLi, sec-BuLi, t-BuLi, etc. to yield the corresponding anionic species. These anions may also be generated via halogen-metal exchange employing n-BuLi, or other alkyllithium reagents. These reactions may be performed in THF, ether, dioxane, DME, benzene, etc. at −78° C. to room temperature. 




For reviews of these metallations and halogen-metal exchange reactions see Organometallics in Organic Synthesis, FMC Corp., Lithium Division, 1993, pp. 17-39; Lithium Link, FMC Corp., Spring 1993, pp. 2-17; n-Butyllithium in Organic Synthesis, Lithium Corp. of America, 1982, pp. 8-16; G. Heinisch, T. Langer, P. Lukavsky, J. Het. Chem. 1997, 34, 17-19. The anions can then be quenched with electrophile 155 or its positional isomers to yield the corresponding C-alkylated heterocyclic pyrrolidine or piperidine 157.

Another method for the synthesis of C-substituted heterocyclic-methylpyrrolidines or piperidines can be shown in Scheme 36. The protected aldehyde 158 can be reacted with the anion of the heterocycle (its generation as described previously) at −78° C. to room temperature with or without CeCl3 in an inert solvent such as THF, ether, dioxane, DME, benzene, etc. to yield carbinol 159. Catalytic hydrogenation of the alcohol yields the corresponding methylene compound 157. Other reduction methods include Et3SiH/TFA (J. Org. Chem. 1969, 34, 4; J. Org. Chem. 1987, 52, 2226) amongst others familiar to one skilled in the art. It can be understood by one skilled in the art that the aldehyde group can be located in other positions instead of, for example, the 4-position of piperidine in compound 158 as depicted in Scheme 36. It can be to be understood that other heterocycles may also be used besides the ones shown in Scheme 35 and 36. 




The anions of the methyl-substituted heterocycles may also be reacted with a BOC-protected piperidone or pyrrolidone (160) to yield alcohols 161 as shown in Scheme 22 (see above reviews on metallations for references). These alcohols may be reduced using PtO2 and TFA (P. E. Peterson and C. Casey, J. Org. Chem. 1964, 29, 2325-9) to yield piperidines and pyrrolidines 162. These can subsequently be taken on to the compounds of this invention as described previously. It can be understood by one skilled in the art that the carbonyl group can be located in other positions instead of, for example, the 4-position of piperidine in compound 160 as depicted in Scheme 37. It can be to be understood that other heterocycles may also be used besides the ones shown in Scheme 37. 




One may also react aryl (phenyl, naphthyl, etc.) anions, generated either by halogen-metal exchange or by ortho-directed metallation (Snieckus, V. Chem. Rev. 1990, 90, 879-933) using n- or s- or t-BuLi in a non-hydroxylic solvent such as THF, ether, etc., with or without TMEDA and allow them to react with compounds 155, 158, and 160 with subsequent elaboration to yield the compounds of this invention by the methods depicted in Schemes 34-37.
Another method for the preparation of C-substituted heterocycles can be shown in Scheme 38. Protected piperidone 160 undergoes a Wittig reaction with heterocyclic phosphorous ylides to yield 163. Hydrogenation over a noble metal catalyst such as Pd in an alcoholic solvent or with an optically active transition metal catalyst (see asymmetric hydrogenation references of Parshall and Coleman, op. cit.) yields 164 which can be further elaborated into the compounds of this invention by the procedures described previously. It will be appreciated by one skilled in the art that the carbonyl group can be located in other positions instead of, for example, the 4-position of piperidine in compound 160 as depicted in Scheme 38. It can be to be understood that other heterocycles may also be used besides the ones shown in Scheme 38. 




Syntheses of amines 9, 10, and the amines which are precursors to isocyanates or isothiocyanates 5 will now be discussed. For example, nitrobenzeneboronic acid (165: Scheme 39) can undergo Suzuki couplings (Suzuki, A. Pure Appl. Chem. 1991, 63, 419) with a wide variety of substituted iodo- or bromo aryls (aryls such as phenyl, naphthalene, etc.), heterocycles, alkyls, akenyls (Moreno-manas, M., et al., J. Org. Chem., 1995, 60, 2396), or alkynes. It can also undergo coupling with triflates of aryls, heterocycles, etc. (Fu, J.-m, Snieckus, V. Tet. Lett. 1990, 31, 1665-1668). Both of the above reactions can also undergo carbonyl insertion in the presence of an atmosphere of carbon monoxide (Ishiyama, et al., Tet. Lett. 1993, 34, 7595). These nitro-containing compounds (167 and 169) can then be reduced to the corresponding amines either via catalytic hydrogenation, or via a number of chemical methods such as Zn/CaCl2 (Sawicki, E. J Org Chem 1956, 21). The carbonyl insertion compounds (158) can also undergo reduction of the carbonyl group to either the CHOH or CH2 linkages by methods already discussed (NaBH4 or Et3SiH, TFA, etc.). These amines can then be converted to isocyanate 5 via the following methods (Nowakowski, J. J Prakt Chem/Chem-Ztg 1996, 338 (7), 667-671; Knoelker, H.-J. et al., Angew Chem 1995, 107 (22), 2746-2749; Nowick, J. S. et al., J Org Chem 1996, 61 (11), 3929-3934; Staab, H. A.; Benz, W.; Angew Chem 1961, 73); to isothiocyanate 5 via the following methods (Strekowski L. et al., J Heterocycl Chem 1996, 33 (6), 1685-1688; Kutschy, Pet al., Synlett 1997, (3), 289-290); to carbamoyl chloride 11 (after 1168 or 170 can be reductively aminated with an R2 group) (Hintze, F.; Hoppe, D.; Synthesis (1992) 12, 1216-1218); to thiocarbamoyl chloride 11 (after 168 or 170 can be reductively aminated with an R2 group) (Ried, W.; Hillenbrand, H.; Oertel, G.; Justus Liebigs Ann Chem 1954, 590); or just used as 9, or 10 (after 168 or 170 can be reductively aminated with an R2 group), in synthesizing the compounds of this invention by the methods depicted in Scheme 1. 




Likewise, protected aminobromobenzenes or triflates or protected aminobromoheterocycles or triflates 171 (Scheme 40) may undergo Suzuki-type couplings with arylboronic acids or heterocyclic boronic acids (172). These same bromides or triflates 171 may also undergo Stille-type coupling (Echavarren, A. M., Stille, J. K. J. Am. Chem. Soc., 1987, 109, 5478-5486) with aryl, vinyl, or heterocyclic stannanes 175. Bromides or triflates 171 may also undergo Negishi-type coupling with other aryl or heterocyclic bromides 176 (Negishi E. Accts. Chem. Res. 1982, 15, 340; M. Sletzinger, et al., Tet. Lett. 1985, 26, 2951). Deprotection of the amino group yields an amine with can be coupled to make a urea and other linkers containing Z as described above and for Scheme 1. Amino protecting groups include phthalimide, 2,4-dimethyl pyrrole (S. P. Breukelman, et al. J. Chem. Soc. Perkin Trans. I,1984, 2801); N-1,1,4,4-Tetramethyldisilyl-azacyclopentane (STABASE) (S. Djuric, J. Venit, and P. Magnus Tet. Lett 1981, 22, 1787) and others familiar to one skilled in the art. 




Many amines are commercially available and can be used as 9, 10, or used as precursors to isocyanates or isothiocyanates 5. There are numerous methods for the synthesis of non-commercially available amines familiar to one skilled in the art. For example, aldehydes and ketones may be converted to their O-benzyl oximes and then reduced with LAH to form an amine (Yamazaki, S.; Ukaji, Y.; Navasaka, K.; Bull Chem Soc Jpn 1986, 59, 525). Ketones and trifluoromethylketones undergo reductive amination in the presence of TiCl4 followed by NaCNBH4 to yield amines (Barney, C. L., Huber, E. W., McCarthy, J. R. Tet. Lett. 1990, 31, 5547-5550). Aldehydes and ketones undergo reductive amination with Na(AcO)3BH as mentioned previously to yield amines (Abdel-Magid, A. F., et al. Tet. Lett. 1990, 31, (39) 5595-5598). Amines may also be synthesized from aromatic and heterocyclic OH groups (for example, phenols) via the Smiles rearrangement (Weidner, J. J., Peet, N. P. J. Het. Chem., 1997, 34, 1857-1860). Azide and nitrile displacements of halides, tosylates, mesylates, triflates, etc. followed by LAH or other types or reduction methods yield amines. Sodium diformyl amide (Yinglin, H., Hongwen, H. Synthesis 1989 122), potassium phthalimide, and bis-BOC-amine anion can all displace halides, tosylates, mesylates, etc., followed by standard deprotection methods to yield amines, procedures which are familiar to one skilled in the art. Other methods to synthesize more elaborate amines involve the Pictet-Spengler reaction, imine/immonium ion Diels-Alder reaction (Larsen, S. D.; Grieco, P. A. J. Am. Chem. Soc. 1985, 107, 1768-69; Grieco, P. A., et al., J. Org. Chem. 1988, 53, 3658-3662; Cabral, J. Laszlo, P. Tet. Lett. 1989, 30, 7237-7238; amide reduction (with LAH or diborane, for example), organometallic addition to imines (Bocoum, A. et al., J. Chem. Soc. Chem. Comm. 1993, 1542-4) and others all of which are familiar to one skilled in the art.
Compounds where Z=N—CN, CHNO2, and C(CN)2 can be synthesized by the methods shown in Scheme 41. Thus amine 108 reacts with malononitrile 179 neat or in an inert solvent at room temperature to the reflux temperature of the solvent, or at the melting point of the solid/solid mixture, to yield malononitrile 178. This in turn can undergo reaction with amine 177 under similar conditions stated just above to yield molononitrile 181. Likewise, a similar reaction sequence may be used to make 184 and 187 [for Z=C(CN)2], see for example P. Traxler, et al., J. Med. Chem. (1997), 40, 3601-3616; for Z=N—CN, see K. S. Atwal, J. Med. Chem. (1998) 41, 271; for Z=CHNO2, see J. M. Hoffman, et al., J. Med. Chem. (1983) 26, 140-144). 




Additionally, the starting materials in the Schemes 6 through 29 can be modified with an a one-carbon longer or shorter length chain or ring size starting material and be applicable to the synthesis of five and seven-membered ring analogs. In some of the synthetic schemes, an intermediate may be easily modified to lengthen or shorten the chain length as shown in Scheme 42. To homologate alcohol 188, the mesylate can be displaced with cyanide. Lithium aluminum hydride reduction of the nitrile can give the amine 189. Alternatively, basic hydrolysis of the nitrile and lithium aluminum hydride reduction of the resulting acid can give the alcohol 190. To decrease the chain by one carbon, the mesylate of alcohol 188 can be eliminated to the olefin which upon treatment with ozone and reductive workup can give alcohol 191. In those schemes where an olefin can be hydroborated, to reduce the chain size by one carbon, the hydroboration step may be replaced with ozonolysis with an reductive workup (not shown in Scheme 42). 




Scheme 43 describes the synthesis of carbamate- and urea-containing heterocycles. Olefin 70 can undergo ozonolysis with reductive workup, mesylate formation, azide displacement and catalytic reduction to give amine 192. Selective fluoride deprotection followed by ring closure with carbonyl diimidazole (Kaiser, A.; Balbi, M.; Tetrahedron: Asymmetry 1999, 10(5), 1001) can give carbamate 193. Fluoride deprotection and Swern oxidation completes the synthesis of aldehyde 194. Alternatively, oxidation with PDC can give acid 195. While only one regioisomer and ring size is shown, other regioisomers and ring sizes can be prepared by varying the chain lengths relative to the chiral centers as shown in the preceding schemes and then performing the ring closure. 




Scheme 44 describes the preparation of cyclic ureas, olefin 70 can undergo ozonolysis with reductive workup, mesylate formation, azide displacement and selective fluoride deprotection to give azide 196. Mesylate formation, azide displacement, catalytic hydrogenation followed by ring closure with carbonyl diimidazole can give urea 197. Fluoride deprotection and Swern oxidation completes the synthesis of aldehyde 198. Alternatively, oxidation with PDC can give acid 199. 










The regioisomeric 3,4-disubstituted dihydropyrans prepared in Scheme 11 can also be prepared using the route shown in Scheme 45. Acid-catalyzed trans-esterification of γ-butyrolactone 200 can provide the hydroxyester 201, which can undergo rhodium-catalyzed carbene insertion to provide the diester 202. Dieckmann cyclization can provide the ketoester 203, which can be converted to the β-aminoester 205 as already described for the preparation of other β-aminoesters. The trans isomer can be obtained either by reduction of the intermediate enamine 204 with sodium triacetoxyborohydride followed by base-catalyzed epimerization as already described, or by reduction of 204 with triethylsilane in trifluoroacetic acid. The ester can then be hydrolyzed to the acid 206, followed by coupling to give the amide 207. The benzyl group can be removed by hydrogenolysis to the amine 208, followed by reduction of the amide to 209 and reaction with an isocyanate or carbamate to provide the products 210. 




A number of 5-membered heterocyclic β-ketoesters can be prepared using methods demonstrated in the literature, and converted to the analogous products using reaction sequences similar to those already described. For example as in Scheme 46, methyl 4-keto-tetrahydrothiophene-3-carboxylate 211 and methyl 3-keto-tetrahydrothiophene-2-carboxylate 212 can be prepared as described by O. Hromatka, D. Binder and K. Eichinger, Monatsheft. Chem. 1973, 104, 1520. Ethyl 4-ketopyrrolidine-3-carboxylate 213 and ethyl 3-ketopyrrolidine-2-carboxylate 214, bearing a carbamate protecting group on the ring nitrogen atom, may be prepared as described by J. Blake, C. D. Willson and H. Rapoport, J. Am. Chem. Soc. 1964, 86, 5293, and converted to various products using chemistry analogous to that already described.
A synthetic route to (3R,4S)-4-[(R)-1-phenylethylamino]-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester 215 has been described by X. Wang, J. F. Espinosa and S. H. Gellman, J. Am. Chem. Soc. 2000, 122, 4821. A synthetic route to (2R,3R)-3-benzyloxycarbonylamino-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester 216 has been described by S. H. Gellman, D. H. Appella, L. A. Christianson, D. A. Klein, S. Krauthauser, Y. J. Chung, and X. Wang, U.S. Pat. No. 6,060,585. The preparation of 1-substituted analogs of (3R,4S)-4-tert-butoxycarbonylamino-5-oxo-pyrrolidine-3-carboxylic acid benzyl ester 217 has been described by D. S. Garvey, P. D. May and A. M. Nadzan, J. Org. Chem. 1990, 55, 936. The preparation of the enantiomer of N-benzyl-N-[(2R,3R)-2-formyl-5-oxo-pyrrolidin-3-yl]-acetamide 218 has been described by N. Langlois and M. Radom, Tetrahedron Lett 1998, 39, 857. These intermediates may be converted to the corresponding final products using synthetic transformations disclosed herein.
EXAMPLES
Example 1
Part A: Preparation of 4-oxopiperidine-1,3-dicarboxylic acid 1-t-butyl ester 3-methyl ester
In a dry flask 4-oxo-3-piperidinecarboxylic acid methyl ester hydrochloride (15.01 g, 77.52 mmol) was dissolved in tetrahydrofuran (100 mL) and triethylamine (22 mL, 158 mmol) was added. After stirring for 10 minutes, di-t-butyl dicarbonate (18.6 g, 85.2 mmol) was added and the reaction mixture was stirred for 6 hours. The mixture was concentrated in vacuo, dissolved in ethyl acetate (50 mL) and extracted twice with water (25 mL). The aqueous extracts were combined and extracted with ethyl acetate (50 mL). The combined organic extracts were dried with magnesium sulfate, filtered and concentrated in vacuo to give a light yellow oil (23.05 g, 100%) which was taken on without further purification.
1H NMR (300 MHz, CDCl3), δ: 11.97 (s, 1H), 4.05 (s, 2H), 3.78 (s, 3H), 3.57 (t, 2H, J=6), 2.37 (t, 2H, J=6), 1.48 (s, 9H).
Part B: Preparation of (R)-4-(1-phenyl-ethylamino)-2,5-dihydro-2H-pyridine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester
In a dry flask equipped with a Dean-Stark trap and reflux condenser, 4-oxopiperidine-1,3-dicarboxylic acid 1-t-butyl ester 3-methyl ester (23.05 g, 85.2 mmol) was dissolved in toluene (300 mL). (R)-(+)-a-Methylbenzylamine (12.5 mL, 97.0 mmol) and p-toluenesulfonic acid monohydrate (0.23 g, 1.21 mmol) were added and the mixture heated to reflux for 18 hours. The crude reaction mixture was concentrated in vacuo to give the desired amine (36.92 g, quantitative) as a thick orange oil. 1H NMR (300 MHz, CDCl3), δ: 9.25 (d, 1H, J=7), 7.26 (m, 5H), 4.61 (m, 1H), 4.06 (s, 2H), 3.72 (s, 3H), 3.41 (m, 1H), 3.30 (m, 1H), 2.39 (m, 1H), 2.04 (m, 1H), 1.50 (d, 3H, J=7), 1.43 (s, 9H)
Part C: Preparation of (3S,4R)-4-[(R)-1-phenyl-ethylamino]-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester
In a dry flask (R)-4-(1-phenyl-ethylamino)-2,5-dihydro-2H-pyridine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester (26.72 g crude, 85.2 mmol) was dissolved in acetonitrile (250 mL) and glacial acetic acid (190 mL) and cooled to 0° C. Triacetoxyborohydride (82.31 g, 388 mmol) was added in two portions over a 140-minute period. The reaction mixture was allowed to stir at 0° C. for 30 minutes. The reaction mixture was concentrated in vacuo, removing 170 mL of acetonitrile. The reaction mixture was neutralized by the sequential addition of 1N sodium hydroxide (50 mL), 2N sodium hydroxide (50 mL), 5.7 M sodium hydroxide (50 mL) and concentrated aqueous sodium hydroxide (150 mL) to maintain the internal temperature of the flask below 18° C. Water was added to dissolve the solid sodium acetate. The resulting mixture was extracted with twice with dichloromethane (200 mL). The combined organic extracts were dried with magnesium sulfate, filtered, concentrated in vacuo, and then purified by flash chromatography with 20% ethyl acetate in hexanes to give a colorless oil (30.82 g, 83%). The 1H NMR showed a mixture of two rotation isomers. The major compound had the following 1H NMR (300 MHz, CDCl3), δ: 7.32 (m, 4H), 7.24 (m, 1H), 4.00 (d, 1H, J=9), 3.86 (q, 1H, J=7), 3.72 (s, 3H), 3.67 (m, 1H), 3.16 (dd, 1H, J=14, J′=4), 2.98 (td, 1H, J=12, J′=4), 2.84 (m, 2H), 1.75 (m, 1H), 1.43 (s, 9H), 1.28 (d, 3H, J=7), 1.26 (m, 1H)
Part D: Preparation of (3R,4R)-4-[(R)-1-phenyl-ethylamino]-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester
In a dry flask (3S,4R)-4-[(R)-1-phenyl-ethylamino]-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester (13.78 g, 38.0 mmol) was dissolved in ethanol (400 mL) along with 3 Å molecular sieves (1.04 g). The mixture was heated to reflux over 2.5 hours. Potassium carbonate (26.3 g) was added and refluxing continued for 4 additional hours. The reaction mixture was cooled, filtered through a bed of celite, and concentrated in vacuo to give a crude oil (16.05 g). Purification by flash column chromatography (20-50% ethyl acetate/hexanes) provided a colorless oil (3.24 g, 23%). Unepimerized ethyl ester was also isolated (7.55 g, 53%).
1H NMR (300 MHz, CDCl3), δ: 7.30 (m, 4H), 7.23 (m, 1H), 4.20 (m, 3H), 3.97 (bs, 1H), 3.82 (q, 1H, J=6), 2.89 (m, 2H), 2.66 (t, 1H, J=11), 2.31 (bs, 1H), 1.72 (m, 1H), 1.43 (s, 9H), 1.31 (m, 7H), 1.11 (m, 1H).
Part E: Preparation of (3R,4R)-4-aminopiperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester
In a dry 500-mL Paar flask charged with Palladium hydroxide (20 wt % Pd, dry basis, on carbon, 1.50 g) was added ethanol (75 mL) and (3R,4R)-4-[(R)-1-phenyl-ethylamino]-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (4.30 g, 11.4 mmol). The reaction mixture was hydrogenated at 53 psi for 20.5 hours with vigorous shaking. The reaction mixture was filtered through a plug of celite. The plug was washed with 20 mL of ethanol and the combined filtrates were concentrated in vacuo to give a colorless oil (3.07 g, 99%). 1H NMR (300 MHz, CDCl3), δ: 4.32 (bs, 1H), 4.19 (q, 2H, J=7), 4.19 (bs, 1H), 3.08 (td, 1H, J=11, J′=3), 2.75 (bt, 2H, J=14), 2.29 (td, 1H, J=11, J′=4), 1.89 (m, 1H), 1.46 (s, 9H), 1.38 (td, 1H, J=12, J′=5), 1.28 (t, 3H, J=7).
Part F: Preparation of (3R,4R)-4-benzyloxycarbonylamino-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester
In a dry flask (3R,4R)-4-aminopiperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (3.07 g, 11.3 mmol) was dissolved in dichloromethane (100 mL) and triethylamine (2.1 mL, 15.1 mmol) and benzyl chloroformate (2.0 mL, 12.6 mmol) were added. The mixture was stirred for 22 hours. Water (30 mL) was added and the layers separated. The aqueous layer was extracted with dichloromethane (30 mL). The combined organic layers were dried with magnesium sulfate, filtered, and concentrated in vacuo to give a crude oil (4.91 g). Purification by flash column chromatography (40% ethyl acetate/hexanes) provided a colorless oil (2.37 g, 51%). 1H NMR (300 MHz, CDCl3), δ: 7.33 (m, 5H), 5.08 (s, 2H), 4.71 (s, 1H), 4.12 (m, 4H), 3.90 (m, 1H), 2.98 (bs, 1H), 2.85 (t, 1H, J=13), 2.37 (m, 1H), 2.06 (d, 1H, J=7), 1.45 (s, 9H), 1.37 (m, 1H), 1.20 (t, 3H, J=7).
Part G: Preparation of (3R,4R)-4-benzyloxycarbonylamino-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester
In a flask (3R,4R)-4-benzyloxycarbonylamino-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (2.98 g, 7.33 mmol) was dissolved in tetrahydrofuran (120 mL) and lithium hydroxide (15 mL of a 1N aqueous solution, 15 mmol) was added. The mixture was stirred for 68 hours. The reaction was concentrated in vacuo to one-third the original volume. Water (50 mL) and diethyl ether (50 mL) were added and the layers separated. The aqueous layer was extracted with diethyl ether twice (30 mL). The aqueous layer was acidified with aqueous hydrochloric acid (6.5 mL of a 2M solution) and then extracted with ethyl acetate three times (30 mL). The combined organic layers were dried with magnesium sulfate, filtered, and concentrated in vacuo to give a crude white solid (3.11 g) which was used without further purification. 1H NMR (300 MHz, CDCl3), δ: 7.36 (m, 5H), 5.12 (m, 2H), 4.91 (bs, 1H), 4.24 (bs, 1H), 4.09 (bs, 1H), 3.92 (bs, 1H), 3.01 (bs, 1H), 2.87 (m, 1H), 2.44 (m, 1H), 2.05 (bs, 1H), 1.45 (s, 9H), 1.40 (m, 1H).
Part H: Preparation of t-Butyl 3-oxo-1-piperidine-carboxylate
To a stirring solution of N-benzyl-3-piperidone hydrochloride hydrate (4.2 g, 18.6 mmol) and 10% palladium on carbon (0.8 g) in degassed methanol (200 mL) was added hydrogen gas to 55 psi. The reaction mixture was stirred for 16 hr and then filtered through a pad of celite. The celite was washed with methanol (200 mL). The filtrates were combined and concentrated in vacuo to a colorless oil. The oil was dissolved in tetrahydrofuran (200 mL) and then treated with di-t-butyl-dicarbonate (5.27 g, 24.1 mmol) and saturated aqueous sodium bicarbonate (50 mL). The reaction was stirred for 4 hr and then concentrated in vacuo to a white solid. The solid was partitioned between ethyl acetate and 1N hydrochloric acid. The organic layer was separated, washed with 1N sodium hydroxide and brine, dried over Na2SO4, and evaporated in vacuo to a colorless oil. The oil was purified by flash chromatography (silica gel, hexane:ethyl acetate 3:1) to yield 2.93 g as a colorless oil. 1H NMR (300 MHz, CDCl3) δ 3.99 (s, 2H), 3.58 (t, J=6, 2H), 2.46 (t, J=6, 2H), 1.97 (p, J=6, 2H), 1.45 (s, 9H).
Part I: Preparation of t-Butyl 3-(4-fluorobenzylidene)-1-piperidinecarboxylate
To a stirring solution of (4-fluorophenylmethyl)-triphenylphosphonium chloride (17.68 g, 43.5 mmol) in dry tetrahydrofuran (60 mL) at −78° C. was added 2.5 M n-butyllithium in hexane (14.6 mL, 36.5 mmol). The reaction was warmed to 0° C. for 1 hr and t-Butyl 3-oxo-1-piperidinecarboxylate (3.46 g, 17.4 mmol) in tetrahydrofuran (60 mL) was added. The mixture was stirred at room temperature for 1 hr and the heated to reflux for 16 hr. The reaction was cooled to room temperature and quenched by the addition of saturated aqueous ammonium chloride. The reaction was extracted with ethyl acetate three times (100 mL). The organic layers were combined, washed with brine, dried over magnesium sulfate, and evaporated in vacuo to a pale yellow oil. The oil was purified by flash chromatography (silica gel, hexane:ethyl acetate 9:1) to yield 3.82 g of a mixture of E and Z isomers as a colorless oil. 1H NMR (300 MHz, CDCl3) δ 7.22-7.14 (m, 2H), 7.04-6.98 (m, 2H), 6.36 (s, 0.33H), 6.28 (s, 0.67H), 4.14 (s, 1.34H), 4.00 (s, 0.66H) 3.50 (t, J=5, 2H), 2.47 (t, J=5, 0.66H), 2.39 (t, J=5, 1.34H), 1.75-1.68 (m, 1.34H), 1.65-1.57 (m, 0.66H), 1.48 (s, 9H).
Part J: Preparation of t-Butyl (±)-3-(4-fluorobenzyl)-1-piperidinecarboxylate
To a stirring solution of the t-Butyl 3-(4-fluorobenzylidene)-1-piperidinecarboxylate (3.82 g, 13.1 mmol) and 10% palladium on carbon (0.76 g) in degassed methanol (200 mL) was added hydrogen gas to 55 psi. The reaction was stirred for 16 h and then filtered through a pad of celite. The celite was washed with methanol (200 mL). The filtrates were combined and concentration in vacuo to yield 2.76 g as a colorless oil. 1H NMR (300 MHz, CDCl3) δ 7.12-7.07 (m, 2H), 6.98-6.93 (m, 2H), 3.89 (dt, J=13, J′=4, 1H), 3.84-3.74 (m, 1H), 2.57-2.43 (m, 4H), 1.75-1.60 (m, 4H), 1.42 (s, 9H), 1.15-1.09 (m, 1H).
Part K: Preparation of (3S)-3-(4-fluorobenzyl)piperidine, mandelic acid salt
N-BOC-3-(4-fluorobenzyl)piperidine (5 g) was dissolved in 30 mL of 4N hydrochloric acid in dioxane. Some initial gassing occurred which eventually subsided. After one hour, the mixture was neutralized with aqueous Na2CO3, and the dioxane was evaporated off. The residue was then extracted with ether. The combined ether extracts were dried over magnesium sulfate and evaporated off to give 2.6 g of the free amine as a discolored oil. This crude material was used to make the diastereomeric salts.
Resolution of 3-(4-fluorobenzyl)piperidine
The crude racemic 3-(4-fluorobenzyl)piperidine (2.0 g) was dissolved in 25 mL acetonitrile and heated to reflux. The solution was hazy. To this was added 1.56 g (1 equiv.) of (R)-(−) mandelic acid dissolved in 15 mL acetonitrile. Some initial precipitation occurred when the cooler solution was added but it did redissolve when refluxing resumed. The heat was turned off and small amounts of enantiomerically pure salt was added as the temperature dropped. At first the seed crystals dissolved, but when the temperature dropped to 75° C., they remained suspended in the stirred solution. After a few more degrees of cooling, crystal growth was obvious. Cooling was continued at the rate of 1 degree/min. At 50° C., the solution was filtered to recover 0.9 g of salt, which melted at 164° C. It was recrystallized from acetonitrile twice to give (S)-(+)-3-(4-fluorobenzyl)piperidine mandelic acid salt in 98% ee, and melting at 168-171° C.
Part L: Preparation of (3R,4R)-4-benzyloxycarbonylamino-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidine-1-carboxylic acid t-butyl ester
(S)-3-(4-fluorobenzyl)-piperidine, mandelic acid salt (4.33 g, 12.5 mmol) is dissolved in 1N sodium hydroxide (100 mL) and extracted with ethyl acetate (50 mL) three times. The combined organic extracts were dried with magnesium sulfate, filtered, concentrated in vacuo and used without further purification.
In a flask (3R,4R)-4-benzyloxycarbonylamino-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester (3.93 g, 10.4 mmol) was dissolved in dichloromethane (200 mL) and then benzotriazol-1-yloxy-tripyrrolidinophosphonium hexafluorophosphate (6.48 g, 12.5 mmol) and triethylamine (3.3 mL, 23.7 mmol) were added. After stirring for 5 minutes, (S)-3-(4-fluorobenzyl)-piperidine (2.21 g, 11.4 mmol) was added. The mixture was stirred for 16 hours. The reaction mixture was extracted with water (50 mL) and brine (50 mL). The organic layer was dried with magnesium sulfate, filtered, and concentrated in vacuo to give a crude orange glass (10.49 g). Purification by flash column chromatography (50-70% ethyl acetate/hexanes) provided a colorless oil (4.79 g, 83%). 1H NMR (300 MHz, CDCl3), δ: 7.32 (m, 2H), 7.26 (m, 3H), 7.07 (m, 2H), 6.95 (m, 2H), 5.04 (m, 2H), 4.41 (d, 1H, J=13), 4.12 (bm, 2H), 3.83 (bm, 2H), 3.06 (bm, 1H), 2.76 (bs, 2H), 2.60 (dd, 2H, J=14, J′=6), 2.37 (m, 2H), 1.90 (bs, 1H), 1.63 (bm, 2H), 1.45 (m, 9H), 1.12 (m, 3H), 0.87 (m, 1H).
Part M: Preparation of (3R,4R)-4-amino-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidine-1-carboxylic acid t-butyl ester
In a dry 500-mL Paar flask charged with 10 wt % palladium on carbon (0.050 g) and (3R,4R)-4-benzyloxycarbonylamino-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidine-1-carboxylic acid t-butyl ester (0.25 g, 0.451 mmol) was added methanol (15 mL). The reaction mixture was hydrogenated at 48 psi for 18 hours with vigorous shaking. The reaction mixture was filtered through a plug of celite. The plug was washed with 20 mL of methanol and the combined filtrates were concentrated in vacuo to give a white solid (0.183 g, 97%). 1H NMR (300 MHz, CDCl3), δ: 8.11 (bs, 2H), 7.15 (m, 2H), 6.97 (t, 2H, J=8), 4.23 (bm, 3H), 3.88 (m, 1H), 3.67 (bs, 1H), 3.13 (m, 1H), 2.60 (bm, 5H), 2.31 (bd, 1H, J=12), 1.74 (bm, 6H), 1.47 (2s, 9H), 1.20 (m, 1H). MS (ESI), m+/z: (M+H)+=420.3.
Part N: Preparation of (3R,4R)-4-[3-(3-acetyl-phenyl)-ureido]-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidine-1-carboxylic acid t-butyl ester
In a dry flask (3R,4R)-4-amino-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidine-1-carboxylic acid t-butyl ester (56 mg, 0.133 mmol) was dissolved in tetrahydrofuran (2 mL) and triethylamine (24 μL, 0.172 mmol) and 3-acetylphenylisocyanate (22 μL, 0.160 mmol) were added. The reaction mixture was stirred for 17 hours. One-half of the original reaction mixture (1 mL) was concentrated in vacuo then purified by preparative reverse-phase HPLC (10-80% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (24 mg, 62%). 1H NMR (400 MHz, DMSO, 120° C.), δ: 8.32 (s, 1H), 7.91 (t, 1H, J=2), 7.58 (m, 1H), 7.48 (m, 1H), 7.33 (t, 1H, J=8), 7.15 (m, 2H), 6.99 (m, 2H), 5.98 (d, 1H, J=10), 4.04 (bd, 1H, J=13), 3.89 (bm, 4H), 3.20 (bs, 2H), 2.96 (m, 2H), 2.86 (m, 2H), 2.50 (s, 3H), 2.46 (m, 2H), 1.90 (m, 1H), 1.62 (bm, 4H), 1.43 (2s, 9H), 1.20 (m, 1H). HRMS (ESI), C32H42FN4O5 m+/z: calc.=581.3139, found=581.3141.
Example 2
Preparation of 1-(3-acetyl-phenyl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidin-4-yl}-urea, trifluoroacetic acid salt
In a dry flask (3R,4R)-4-[3-(3-acetyl-phenyl)-ureido]-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidine-1-carboxylic acid t-butyl ester 24 mg, 0.041 mmol in 1 mL of tetrahydrofuran) was concentrated in vacuo, redissolved in dichloromethane (1 mL), and trifluoroacetic acid (0.5 mL) was added. The reaction mixture was stirred for 5 hours. The reaction mixture was concentrated in vacuo then purified by preparative reverse-phase HPLC (10-80% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (22 mg, 89%). 1H NMR (400 MHz, DMSO, 120° C.), δ: 8.44 (bm, 3H), 7.96 (bs, 1H), 7.59 (m, 1H), 7.51 (m, 1H), 7.36 (t, 1H, J=8), 7.16 (m, 2H), 7.01 (t, 2H, J=9), 6.60 (d, 1H, J=7), 4.17 (d, 1H, J=13), 4.08 (bs, 1H), 3.90 (m, 1H), 3.43 (bs, 1H), 3.23 (m, 2H), 3.13 (m, 2H), 3.04 (bs, 2H), 2.51 (s, 3H), 2.46 (m, 2H), 1.97 (m, 2H), 1.67 (bd, 3H, J=9), 1.42 (bs, 1H), 1.19 (m, 1H). HRMS (ESI), C27H34FN4O3 m+/z: calc.=481.2615, found=481.2614.
Example 3
Part A: Preparation of N-methyl-3-nitro-benzamide
In a dry flask 3-nitrobenzoyl chloride (7.00 g, 37.7 mmol) was dissolved in tetrahydrofuran (300 mL) and methylamine (41.5 mL of a 2.0 M solution in tetrahydrofuran, 82.9 mmol) was added. The reaction mixture was stirred for 2 hours. The reaction mixture was diluted with ethyl acetate (500 mL) and extracted with water three times (100 mL). The organic layer was dried with sodium sulfate, filtered, and concentrated in vacuo. The crude solid (6.38 g, 94%) was used with further purification. 1H NMR (300 MHz, CDCl3), δ: 8.84 (bs, 1H), 8.67 (m, 1H), 8.37 (dd, J=8, J′=2, 1H), 8.28 (d, J=7, 1H), 7.78 (dd, J=8, J′=7, 1H), 2.83 (m, 3H). MS (ESI), m+/z: (M+H)+=181.
Part B: Preparation of 1-methyl-5-(3-nitrophenyl)-tetrazole
In a dry flask N-methyl-3-nitro-benzamide (30.0 g, 167 mmol) was dissolved in acetonitrile (835 mL) and sodium azide (10.9 g, 167 mmol) was added and the reaction cooled in an ice bath. Triflic anhydride (29 mL, 172 mmol) was added dropwise to maintain the internal temperature below 3° C. The reaction mixture was stirred for 3.5 hours at 0° C. The reaction mixture was poured into 1N aqueous sodium hydroxide (100 mL). The organic layer was separated dried with sodium sulfate, filtered, and concentrated in vacuo to 50 mL. The solution was diluted with dichloromethane and added water to precipitate a yellow solid (18.46 g, 54%). A second crop of crystals was obtained by concentrated the filtrate in vacuo and adding it to boiling ethyl acetate. Upon cooling to 0° C., 6.07 g (18%) of additional material was isolated upon filtration further purification. 1H NMR (300 MHz, CDCl3), δ: 8.67 (m, 1H), 8.49 (dd, J=8, J′=2, 1H), 8.31 (d, J=8, 1H), 7.94 (dd, J=8, J′=8, 1H), 4.22 (s, 3H).
Part C: Preparation of 1-methyl-5-(3-amino-phenyl)-tetrazole
In a Paar flask 1-methyl-5-(3-nitrophenyl)-tetrazole (28.8 g, 140 mmol) was dissolved in ethyl acetate (430 mL) and methanol (1270 mL) and added to palladium on carbon (2.7 g, 10 wt %). The reaction mixture was hydrogenated for 1.5 hours with vigorous shaking. The reaction mixture was filtered, and concentrated in vacuo to give a white solid (24.0 g, 98%) was used with further purification. 1H NMR (300 MHz, CDCl3), δ: 7.21 (dd, J=8, J′=7, 1H), 6.99 (s, 1H), 6.90 (d, J=7, 1H), 6.76 (d, J=8, 1H), 5.44 (bs, 2H), 4.10 (s, 3H).
Part D: Preparation of [3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-carbamic acid phenyl ester
In a dry flask of 1-methyl-5-(3-aminophenyl)-tetrazole (24.0 g, 137 mmol) was dissolved in dichloromethane (1.4 L) and 2,6-lutidine (44.1 g, 411 mmol) was added. Phenyl chloroformate (21.2 g, 136 mmol) was added in 4 portions over 15 minutes, then the reaction was stirred for 1.5 hours. The reaction was poured into 1N aqueous hydrochloric acid (200 mL) and the mixture was extracted with dichloromethane three times (200 mL). The combined organic layers were washed with brine, dried with sodium sulfate, filtered, and concentrated in vacuo. The crude brown material was dissolved in hot toluene, filtered, and allowed to precipitate at 0° C. to give 34.1 g of a white solid. The filtrate was concentrated and recrystallized from toluene again to give an additional crop of off-white crystals (3.44 g, 93% total). 1H NMR (300 MHz, CDCl3), δ: 10.51 (bs, 1H), 8.01 (s, 1H), 7.71 (dt, J=7, J′=2, 1H), 7.55 (m, 2H), 7.41 (m, 2H), 7.24 (m, 2H), 4.14 (s, 3H).
Part E: Preparation of (3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-4-{3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-ureido}-piperidine-1-carboxylic acid t-butyl ester
In a dry flask (3R,4R)-4-amino-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidine-1-carboxylic acid t-butyl ester (350 mg, 0.834 mmol) was dissolved in dimethylformamide (5 mL) and [3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-carbamic acid phenyl ester (285 mg, 0.965 mmol) was added. The reaction mixture was stirred for 19 hours. The reaction mixture was diluted with ethyl acetate and extracted three times with water. The combined aqueous extracts were extracted with ethyl acetate. The combined organic extracts were washed with brine, dried with sodium sulfate, filtered and concentrated in vacuo. The resulting oil was purified by flash column chromatography with 70-100% ethyl acetate/hexanes to give a solid (387 mg, 75%). A small amount was further purified by preparative reverse-phase HPLC (10-80% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (33 mg, 62%). 1H NMR (300 MHz, CDCl3), δ: 7.88 (m, 1H), 7.49 (m, 2H), 7.40 (m, 1H), 7.19 (m, 1H), 7.01 (m, 1H), 6.95 (m, 1H), 6.86 (m, 1H), 4.31 (m, 1H), 4.17 (s, 3H), 4.03 (m, 4H), 3.16 (m, 1H), 3.05 (m, 1H), 2.88 (m, 3H), 2.67 (m, 1H), 2.50 (m, 2H), 2.37 (m, 1H), 1.95 (m, 1H), 1.65 (m, 5H), 1.47 (s, 9H), 1.23 (m, 1H). HRMS (ESI), C32H42FN8O4 m+/z: calc.=621.3313, found=621.3337.
Example 4
Preparation of 1-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidin-4-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea, trifluoroacetic acid salt
In a dry flask (3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-4-{3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-ureido}-piperidine-1-carboxylic acid t-butyl ester (348 mg, 0.561 mmol) was dissolved in dichloromethane (8 mL), and trifluoroacetic acid (3 mL) was added. The reaction mixture was stirred for 2.5 hours. The reaction mixture was concentrated in vacuo then a small quantity was purified by preparative reverse-phase HPLC (10-80% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (37 mg). 1H NMR (300 MHz, CD3OD), δ: 7.95 (d, 1H, J=10), 7.50 (m, 3H), 7.12 (m, 2H), 6.91 (m, 2H), 4.34 (bm, 2H), 4.16 (s, 3H), 3.99 (m, 1H), 3.55 (m, 1H), 3.38 (m, 3H), 3.15 (m, 2H), 2.96-2.61 (m, 1H), 2.47 (m, 2H), 2.07 (bm, 2H), 1.77 (m, 2H), 1.47 (bm, 2H), 1.24 (m, 1H) HRMS (ESI), C27H34FN8O2 m+/z: calc. 521.2789, found=521.2803.
Example 5
Preparation of 1-{1-(2,2-Dimethyl-propionyl)-3-[(3R,4R)-3-((S)-4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidin-4-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea
In a dry flask 1-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidin-4-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea (63 mg, 0.10 mmol) was dissolved in dichloromethane (2 mL), and then triethylamine (70 μmL, 0.50 mmol) and trimethylacetyl chloride (18 μL, 0.15 mmol) were added. The reaction mixture was stirred for 19 hours. The reaction mixture was concentrated in vacuo then was purified by preparative reverse-phase HPLC (10-80% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (42 mg, 70%). 1H NMR (300 MHz, CDCl3), δ: 8.35 (s, 1H), 7.89 (t, 1H, J=2), 7.54 (dq, 1H, J=8, J′=1), 7.44 (t, 1H, J=8), 7.34 (dt, 1H, J=8, J′=1), 7.15 (m, 2H), 6.99 (t, 2H, J=9), 6.00 (d, 1H, J=8), 4.22 (m, 2H), 4.12 (s, 3H), 4.05 (d, 2H, J=14), 3.93 (m, 1H), 3.00 (m, 3H), 2.83 (m, 1H), 2.68 (t, 1H, J=11), 2.56 (dd, 1H, J=14, J′=6), 2.45 (dd, 1H, J=14, J′=7), 1.99 (m, 1H), 1.66 (m, 4H), 1.39 (m, 1H), 1.24 (s, 9H), 1.20 (m, 1H). HRMS (ESI), C32H42FN8O3 m+/z: calc. 605.3363, found=605.3377.
Example 6
Preparation of 1-{1-Acetyl-3-[(3R,4R)-3-((S)-4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidin-4-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea
In a dry flask 1-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidin-4-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea (65 mg, 0.10 mmol) was dissolved in dichloromethane (2 mL), and then triethylamine (70 μL, 0.50 mmol) and acetyl chloride (11 μL, 0.15 mmol) were added. The reaction mixture was stirred for 17 hours. The reaction mixture was concentrated in vacuo then was purified by preparative reverse-phase HPLC (10-80% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (37 mg, 64%). 1H NMR (400 MHz, DMSO-d6, 140° C.), δ: 8.39 (s, 1H), 7.89 (t, 1H, J=2), 7.54 (dq, 1H, J=8, J′=1), 7.44 (t, 1H, J=8), 7.35 (dt, 1H, J=8, J′=1), 7.15 (m, 2H), 6.99 (td, 2H, J=9, J′=2), 6.01 (d, 1H, J=8), 4.12 (s, 3H), 4.02 (bm, 5H), 2.99 (bm, 4H), 2.60 (bm, 2H), 2.44 (dd, 1H, J=14, J′=7), 2.01 (s, 3H), 1.95 (d, 1H, J=10), 1.66 (m, 4H), 1.39 (m, 1H), 1.19 (m, 1H). HRMS (ESI), C25H36FN8O3 m+/z: calc. 563.2894, found=563.2865.
Example 7
Preparation of 1-{(3R,4R)-3-[(S)-3-(4-Fluoro-benzyl)-piperidine-1-carbonyl]-1-methanesulfonyl-piperidin-4-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea
In a dry flask 1-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidin-4-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea (67 mg, 0.11 mmol) was dissolved in dichloromethane (2 mL), and then triethylamine (65 •L, 0.47 mmol) and methanesulfonyl chloride (9 μL, 0.11 mmol) were added. The reaction mixture was stirred for 25 minutes. The reaction mixture was concentrated in vacuo then was purified by preparative reverse-phase HPLC (10-80% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (38 mg, 60%). 1H NMR NMR (400 MHz, DMSO-d6, 140° C.), δ: 8.37 (s, 1H), 7.89 (t, 1H, J=2), 7.54 (d, 1H, J=6), 7.44 (t, 1H, J=8), 7.35 (m, 1H), 7.14 (m, 2H), 6.99 (t, 2H, J=9), 6.05 (d, 1H, J=8), 4.12 (s, 3H), 4.05 (d, 2H, J=14), 3.85 (m, 1H), 3.63 (m, 2H), 3.16 (td, 1H, J=10, J′=4), 2.90 (m, 3H), 2.88 (s, 3H), 2.66 (m, 1H), 2.56 (dd, 1H, J=14, J′=6), 2.44 (dd, 1H, J=14, J′=8), 2.01 (m, 1H), 1.79 (qd, 1H, J=13, J′=4), 1.65 (bs, 3H), 1.40 (m, 1H), 1.20 (m, 1H). HRMS (ESI), C28H36FN8O4S m+/z: calc. 599.2564, found=599.2586.
Example 8
Preparation of 1-{(3R,4R)-3-[(S)-3-(4-Fluoro-benzyl)-piperidine-1-carbonyl]-1-methyl-piperidin-4-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea, trifluoroacetic acid salt
In a dry flask 1-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidin-4-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea (68 mg, 0.11 mmol) was dissolved in dichloroethane (4 mL), and then a solution of formaldehyde (250 μL in tetrahydrofuran) was added. The reaction mixture was stirred for 11 minutes then triacetoxyborohydride (36 mg, 0.17 mmol) was added. The mixture was stirred an additional 4.5 hours. The reaction was quenched with saturated aqueous sodium bicarbonate (1 mL) then diluted with water. The mixture was extracted with dichloromethane three times, dried with magnesium sulfate, filtered and concentrated in vacuo. Then it was purified by preparative reverse-phase HPLC (10-80% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (37 mg, 53%). 1H NMR (400 MHz, DMSO-d6, 140° C.), δ: 8.46 (s, 1H), 7.92 (s, 1H), 7.56 (d, 1H, J=8), 7.46 (t, 1H, J=8), 7.37 (d, 1H, J=8), 7.16 (m, 2H), 7.00 (t, 2H, J=9), 6.48 (bs, 1H), 4.13 (s, 3H), 4.12 (m, 2H), 3.87 (bs, 1H), 3.48 (bs, 1H), 3.21 (bs, 3H), 3.04 (bs, 3H), 2.72 (bs, 3H), 2.53 (m, 1H), 2.49 (m, 1H), 2.01 (m, 2H), 1.69 (m, 3H), 1.43 (bs, 1H), 1.21 (m, 1H). HRMS (ESI), C28H36FN8O2 m+/z: calc. 535.2945, found=535.2945.
Example 9
Part A: Preparation of 5-nitro-indazole-1-carboxylic acid t-butyl ester
In a dry flask 5-nitro-indazole (1.03 g, 6.2 mmol) was dissolved in tetrahydrofuran (25 mL), cooled to 0° C. and sodium hydride (60% in mineral oil, washed with hexanes, 0.25 g) was added. The reaction was stirred for 10 minutes, di-t-butyl dicarbonate (1.35 g, 6.2 mmol) was added and the reaction stirred an additional 10 minutes. The reaction mixture was diluted with ethyl acetate extracted with water and brine, and concentrated in vacuo to give a white solid (1.61 g, 100%). 1H NMR (300 MHz, CDCl3), δ: 8.71 (d, J=2, 1H), 8.43 (dd, J=9, J′=2, 1H), 8.35 (s, 1H), 8.34 (d, J=9, 1H), 1.75 (s, 9H).
Part B: Preparation of 5-amino-indazole-1-carboxylic acid t-butyl ester
In a Paar flask charged with palladium (10 wt % on carbon, 0.44 g) was added ethyl acetate (30 mL) and 5-nitro-indazole-1-carboxylic acid t-butyl ester (1.61 g, 6.2 mmol). The reaction mixture was hydrogenated at 50 psi for 30 minutes with vigorous shaking. The reaction mixture was filtered through a plug of celite. The plug was washed with 20 mL of methanol and the combined filtrates were concentrated in vacuo to give a white solid (1.4 g, 100%). 1H NMR (300 MHz, CDCl3), δ: 7.99 (s, 1H), 7.97 (d, J=10, 1H), 6.94 (dd, J=10, J′=2, 1H), 6.92 (d, J=2, 1H), 1.71 (s, 9H).
Part C: Preparation of 5-phenoxycarbonylamino-indazole-1-carboxylic acid t-butyl ester
In a dry flask 5-amino-indazole-1-carboxylic acid t-butyl ester (1.4 g, 6.0 mmol) was dissolved in tetrahydrofuran (20 mL) and triethylamine (1.0 g, 9.9 mmol) were added and the reaction mixture cooled to 0° C. Phenyl chloroformate (1.0 g, 6.4 mmol) was added dropwise and the mixture was stirred an additional 15 minutes after the addition was complete. The reaction mixture was diluted with ethyl acetate, washed with water, and concentrated in vacuo. The crude material was purified by flash chromatography with 35% ethyl acetate in hexanes to give a white solid (1.9 g, 90%). 1H NMR (300 MHz, CDCl3), δ: 8.14 (d, J=10, 1H), 8.12 (s, 1H), 8.02 (bs, 1H), 7.40 (m, 3H), 7.24 (m, 4H), 1.73 (s, 9H).
Part D: Preparation of 5-(3-{(3R,4R)-1-tert-butoxycarbonyl-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidin-4-yl}-ureido)-indazole-1-carboxylic acid t-butyl ester
In a dry flask (3R,4R)-4-Amino-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidine-1-carboxylic acid t-butyl ester (72 mg, 0.171 mmol) was dissolved in acetonitrile (2 mL) and triethylamine (25 μL, 0.179 mmol) and 5-(phenoxycarbonylamino)-1-indazolecarboxylic acid 1-tert-butyl ester (72 mg, 0.204 mmol) were added. The reaction mixture was stirred for 64 hours while heating to 60° C. The reaction mixture was cooled, diluted with ethyl acetate, washed twice with water and once with brine. The organic layer was dried with magnesium sulfate, filtered and concentrated in vacuo. The crude product was purified by preparative reverse-phase HPLC (10-80% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (71 mg, 61%). 1H NMR (300 MHz, CDCl3), δ: 8.09 (m, 2H), 7.90 (2s, 1H), 7.44 (m, 1H), 7.10 (m, 1H), 6.99 (m, 1H), 6.83 (m, 2H), 4.90 (bs, 1H), 4.43 (bd, 1H, J=11), 4.22 (bs, 2H), 3.98 (bm, 2H), 3.14 (t, 1H, J=13), 2.75 (bm, 4H), 2.45 (bm, 3H), 1.94 (bm, 3H), 1.73 (2s, 9H), 1.48 (m, 9H), 1.45 (bm, 3H), 1.22 (bm, 1H). HRMS (ESI), C36H48FN6O6 m+/z: calc.=679.3619, found=679.3621.
Example 10
Preparation of 5-(3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidin-4-yl}-ureido)-indazole-1-carboxylic acid t-butyl ester, trifluoroacetic acid salt
In a dry flask 5-(3-{(3R,4R)-1-tert-butoxycarbonyl-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidin-4-yl}-ureido)-indazole-1-carboxylic acid t-butyl ester (51 mg, 0.075 mmol) was dissolved in dichloromethane (1.5 mL) and trifluoroacetic acid (0.5 mL) was added. The reaction mixture was stirred for 2.5 hours. The reaction mixture was concentrated in vacuo then purified by preparative reverse-phase HPLC (5-80% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (21 mg, 47%). 1H NMR (400 MHz, DMSO-d6, 140° C.), δ: 8.38 (bs, 2H), 8.03 (s, 1H), 7.89 (s, 1H), 7.75 (s, 1H), 7.41 (d, 1H, J=9), 7.28 (dd, 1H, J=9, J′=2), 7.16 (m, 2H), 7.00 (t, 2H, J=9), 6.41 (d, 1H, J=7), 4.08 (m, 2H), 3.91 (m, 1H), 3.44 (m, 1H), 3.17 (bm, 5H), 2.50 (bm, 3H), 2.00 (m, 2H), 1.69 (d, 3H, J=11), 1.43 (bs, 1H), 1.21 (m, 1H). HRMS (ESI), C26H32FN6O2 m+/z: calc.=479.2571, found=479.2564.
Example 11
Part A: Preparation of (5-acetyl-4-methyl-thiazol-2-yl)-carbamic acid phenyl ester
In a round-bottom flask, NaH 60% dispersion in mineral oil (3.07 g, 77 mmol) was washed 2× with hexane and suspended in DMF. Then 2-amino-5-acetyl-4-methyl-thiazole (10.0 g, 64 mmol) was added and stirred while cooling in an ice bath. Stirring continued until the NaH was consumed. Diphenyl carbonate (34 g, 160 mmol) was added while cooling and after the addition was complete the reaction mixture was stirred for an additional  ̃30 minutes at room temperature. The dimethylformamide was removed on a rotary evaporator (high vacuum, 40° C.) to yield a brown residue. This residue was dissolved in 1 L of chloroform and washed successively with 2 L of 0.5N aqueous hydrochloric acid, twice with 1 L of water, and finally by 1 L of brine. The aqueous portions were back extracted twice with 300 mL of chloroform. The combined organic fractions were dried over anhydrous sodium sulfate, filtered and concentrated on a rotary evaporator to give a white solid. This was chromatographed on silica (15%-70% EtOAc/hexane) to give 15 g of the desired carbamate as a white solid. 1H NMR (300 MHz, CDCl3) δ: 11.42 (bs, 1H), 7.47-7.40 (m, 2H), 7.33-7.27 (m, 1H), 7.22-7.18 (m, 2H), 2.72 (s, 3H), 2.50 (s, 3H). ESI MS: (M+H)+=277.1.
Part B: Preparation of (3R,4R)-4-[3-(5-acetyl-4-methyl-thiazol-2-yl)-ureido]-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidine-1-carboxylic acid t-butyl ester
In a dry flask (3R,4R)-4-Amino-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidine-1-carboxylic acid t-butyl ester (73 mg, 0.174 mmol) was dissolved in acetonitrile (2 mL) and triethylamine (25 μL, 0.179 mmol) and 4-acetyl-3-methyl-2-(phenoxycarbonylamino)-thiazole (58 mg, 0.21 mmol) were added. The reaction mixture was stirred for 64 hours while heating to 60° C. The reaction mixture was cooled, diluted with ethyl acetate, washed twice with water and once with brine. The organic layer was dried with magnesium sulfate, filtered and concentrated in vacuo. The crude product was purified by preparative reverse-phase HPLC (10-80% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (60 mg, 57%). 1H NMR (300 MHz, CDCl3), δ: 7.14 (m, 1H), 6.98 (m, 2H), 6.88 (t, 1H, J=10), 4.39 (d, 1H, J=13), 4.09 (bs, 2H), 3.94 (bm, 2H), 3.12 (t, 1H, J=11), 2.74 (bm, 5H), 2.62 (m, 3H), 2.52 (m, 1H), 2.47 (m, 3H), 2.36 (m, 2H), 2.03 (bm, 3H), 1.74 (bm, 2H), 1.48 (2s, 9H), 1.40 (m, 1H), 1.22 (m, 1H). HRMS (ESI), C30H41FN5O5S m+/z: calc.=602.2813, found=602.2811.
Example 12
Preparation of 1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidin-4-yl}-urea, trifluoroacetic acid salt
In a dry flask (3R,4R)-4-[3-(5-acetyl-4-methyl-thiazol-2-yl)-ureido]-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidine-1-carboxylic acid t-butyl ester (47 mg, 0.078 mmol) was dissolved in dichloromethane (1.5 mL) and trifluoroacetic acid (0.5 mL) was added. The reaction mixture was stirred for 2 hours. The reaction mixture was concentrated in vacuo then purified by preparative reverse-phase HPLC (5-80% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (49 mg, 100%). 1H NMR (400 MHz, DMSO-d6, 120° C.), δ: 8.47 (bs, 2H), 7.15 (t, 2H, J=6), 7.03 (m, 3H), 4.12 (bs, 1H), 3.95 (m, 2H), 3.45 (m, 1H), 3.24 (m, 2H), 3.12 (m, 2H), 2.51 (s, 3H), 2.48 (bm, 3H), 2.40 (s, 3H), 1.98 (m, 2H), 1.67 (bd, 3H, J=10), 1.28 (bm, 3H). HRMS (ESI), C25H33FN5O3S m+/z: calc.=502.2288, found=502.2281.
Example 13
Part A: Preparation of ethyl 3-oxo-4-piperidinecarboxylate
In a dry 500-mL Paar flask charged with palladium hydroxide (20 wt % Pd, dry basis, on carbon, 0.43 g) was added methanol (20 mL) and ethyl 1-benzyl-3-oxo-4-piperidinecarboxylate hydrochloride (5.00 g, 16.8 mmol). The reaction mixture was hydrogenated at 60 psi for 16 hours with vigorous shaking. The reaction mixture was filtered through a plug of celite. The plug was washed with 20 mL of methanol and the combined filtrates were concentrated in vacuo to give a light yellow oil (2.88 g, 100%). 1H NMR (300 MHz, CDCl3), δ: 4.23 (q, J=7, 2H), 3.84 (bs, (2H), 3.37 (m, 2H), 3.15 (m, 1H), 2.68 (m, 2H), 1.32 (t, J=7, 3H). MS (ESI), m+/z: (M+H)++CH3CN=213, (M+H)+=172.
Part B: Preparation of ethyl 1-(t-butoxycarbonyl)-3-oxo-4-piperidinecarboxylate
In a dry flask, the crude ethyl 3-oxo-4-piperidine-carboxylate 2.88 g, 16.8 mmol) is dissolved in methanol (40 mL) and di-t-butyl dicarbonate (4.03 g, 18.5 mmol) and triethylamine (3.74 g, 36.9 mmol) were added. The reaction mixture was stirred under an argon atmosphere for 6 hours at room temperature. The reaction mixture was concentrated in vacuo and then water (30 mL) and ethyl acetate (30 mL) were added. The aqueous layer was separated and then extracted twice with ethyl acetate (30 mL). The combined organic extracts were dried with magnesium sulfate, filtered and concentrated in vacuo. Purification by flash column chromatography (20% ethyl acetate/hexanes) provided 4.19 g (92%) of a colorless oil. 1H NMR (300 MHz, CDCl3), δ: 12.08 (bs, 1H), 4.23 (q, 2H, J=7), 4.03 (bs, 2H), 3.49 (t, 2H, J=6), 2.32 (bt, 2H, J=6), 1.47 (s, 9H), 1.31 (t, 3H, J=7).
Part C: Preparation of (R)-5-(1-phenyl-ethylamino)-3,6-dihydro-2H-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester
In a dry flask equipped with a Dean-Stark trap and reflux condenser, ethyl 1-(t-butoxycarbonyl)-3-oxo-4-piperidinecarboxylate (4.19 g, 15.4 mmol) was dissolved in toluene (50 mL). (R)-(+)-a-Methylbenzylamine (1.91 g, 15.8 mmol) and p-toluenesulfonic acid monohydrate (0.019 g, 0.1 mmol) were added and the mixture heated to reflux for 6 hours. The crude reaction mixture was concentrated in vacuo to give the desired amine (5.78 g, 100%) as a thick orange oil. 1H NMR (300 MHz, CDCl3), δ: 7.36 (t, J=3, 2H), 7.33 (t, J=4, 1H), 7.31 (dd, J=3, J=4, 2H), 4.59 (m, 1H), 4.16 (q, J=7, 2H), 3.59 (m, 2H), 2.34 (m, 2H), 1.58 (bs, 2H), 1.52 (d, J=3, 3H), 1.29 (s, 9H), 1.26 (t, 3H, J=7). MS (ESI), m+/z: (M+H)+=375.
Part D: Preparation of (3R,4R)-3-[(R)-1-phenyl-ethylamino]-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester
In a dry flask (R)-5-(1-phenyl-ethylamino)-3,6-dihydro-2H-pyridine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester (5.78 g, 15.4 mmol) was dissolved in acetonitrile (25 mL) and glacial acetic acid (25 mL) and cooled to 0° C. Triacetoxyborohydride (9.82 g, 46.3 mmol) was added over a 5-minute period. The reaction mixture was allowed to stir at 0° C. for 2 hours. Concentrated aqueous sodium hydroxide was carefully added to maintain the internal temperature of the flask below 10° C. The resulting solid sodium acetate was filtered and the mixture was extracted with ethyl acetate 3 times (50 mL). The combined organic extracts were dried with magnesium sulfate, filtered, concentrated in vacuo, and then purified by flash chromatography with 20% ethyl acetate in hexanes to give a colorless oil (2.6 g, 47%). The 1H NMR showed a mixture of two rotation isomers. The major compound had the following 1H NMR (300 MHz, CDCl3), δ: 7.28 (t, J=5, 2H), 7.25 (t, J=2, 1H), 7.23 (d, J=4, 2H), 4.35 (m, 2H), 4.24 (q, 2H, J=7), 3.96 (m, 2H), 3.15 (bs, 1H), 2.99 (m, 1H), 2.75 (m, 1H) 2.48 (dt, 2H, J=10, 4), 1.86 (m, 1H), 1.68 (m, 1H), 1.39 (s, 9H), 1.26 (d, 3H, J=6), 1.26 (t, 3H, J=7).
Part E: Preparation of (3R,4S)-3-(1-phenyl-ethylamino)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester
In a dry flask (3R,4R)-3-[(R)-1-phenyl-ethylamino]-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester (31.32 g, 83.0 mmol) was dissolved in ethanol (400 mL). Potassium carbonate (68.72 g) was added and the mixture was refluxed for 6 hours. The reaction mixture was cooled, filtered through a bed of celite, and concentrated in vacuo to give a crude oil. Purification by flash column chromatography (20-50% ethyl acetate/hexanes) provided a colorless oil (4.59 g, 15%). Unepimerized ester was also isolated (23.49 g, 75%).
1H NMR (300 MHz, CDCl3), δ: 7.25 (t, J=5, 2H), 7.245 (t, J=2, 2H), 7.20 (d, J=5, 1H), 4.19 (q, J=7, 2H), 3.94 (bd, J=13, 2H), 3.86 (m, 2H), 2.85 (m, 1H), 2.71 (m, 2H), 2.32 (d, J=7, 2H), 2.20 (d, J=15, 1H), 1.68 (bs, 3H), 1.51 (s, 9H). MS (ESI), m+/z: (M+H)+=377.
Part F: Preparation of (3R,4S)-3-amino-piperidine-1,4-dicarboxylic acid 1-t-butyl ester 4-ethyl ester
In a dry 500-mL Paar flask charged with palladium hydroxide (20 wt % Pd, dry basis, on carbon, 1.62 g) was added methanol (50 mL) and (3R,4S)-4-[(R)-1-Phenyl-ethylamino]-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester (5.41 g, 14.4 mmol). The reaction mixture was hydrogenated at 60 psi for 24 hours with vigorous shaking. The reaction mixture was filtered through a plug of celite. The plug was washed with 20 mL of ethanol and the combined filtrates were concentrated in vacuo to give a colorless oil (3.81 g, 100%). 1H NMR (300 MHz, CDCl3), δ: 4.17 (q, J=7, 2H), 3.04 (m, 1H), 2.71 (m, 2H), 2.49 (m, 2H), 2.25 (m, 1H), 1.46 (s, 9H), 1.28 (t, J=7, 3H). MS (ESI), m+/z: (M+H)+=273.
Part G: Preparation of (3R,4S)-3-benzyloxycarbonylamino-piperidine-1,4-dicarboxylic acid 1-t-butyl ester 4-ethyl ester
In a dry flask (3R,4S)-3-aminopiperidine-1,3-dicarboxylic acid 1-t-butyl ester 4-ethyl ester (3.81 g, 14.0 mmol) was dissolved in dichloromethane (40 mL) and triethylamine (3.9 mL, 28.0 mmol) and benzyl chloroformate (2.0 mL, 14.0 mmol) were added. The mixture was stirred for 18 hours. Water (30 mL) was added and the layers separated. The aqueous layer was extracted with ethyl acetate (30 mL). The combined organic layers were dried with magnesium sulfate, filtered, and concentrated in vacuo to give a crude oil. Purification by flash column chromatography (30% ethyl acetate/hexane) provided a colorless oil (1.19 g, 16%). 1H NMR (300 MHz, CDCl3), δ: 7.35 (m, 5H), 5.09 (m, 2H), 4.13, (q, J=7, 2H), 3.88 (m, 2H), 3.78 (m, 1H), 3.17 (m, 2H), 2.62 (m, 1H), 1.86 (m, 2H), 1.45 (s, 9H), 1.22 (t, J=7, 9H). MS (ESI), m+/z: (M+H)+=407.
Part H: Preparation of (3R,4S)-3-benzyloxycarbonylamino-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester
In a flask (3R,4S)-3-benzyloxycarbonylamino-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester (1.19 g, 2.93 mmol) was dissolved in tetrahydrofuran (48 mL) and lithium hydroxide (12 mL of a 1N aqueous solution, 15 mmol) was added. The mixture was stirred for 60 hours. The reaction mixture was acidified with aqueous hydrochloric acid (3 mL of a 2M solution) and then extracted with ethyl acetate three times (30 mL). The combined organic layers were dried with magnesium sulfate, filtered, and concentrated in vacuo to give a crude white solid (1.13 g) which was used without further purification. 1H NMR (300 MHz, CDCl3), δ: 7.35 (m, 5H), 5.10 (m, 2H), 3.91, (m, 2H), 3.19 (m, 1H), 2.71 (m, 2H), 1.92 (m, 1H), 1.74 (m, 2H), 1.45 (s, 9H). MS (APCI), m+/z: (M+H)+=379.
Part I: Preparation of (3R,4S)-3-benzyloxycarbonylamino-4-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidine-1-carboxylic acid t-butyl ester
In a dry flask (3R,4S)-3-benzyloxycarbonylamino-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester (1.13 g, 3.00 mmol) was dissolved in dichloromethane (100 mL) and then triethylamine (1.67 mL, 12.0 mmol) and benzotriazol-1-yloxy-tripyrrolidinophosphonium hexafluorophosphate (1.56 g, 3.00 mmol) were added. The reaction was stirred 18 hours. The reaction mixture was diluted with water (25 mL) and extracted three times with ethyl acetate (25 mL). The combined organic extracts were dried with magnesium sulfate, filtered and concentrated in vacuo. The mixture was purified by flash chromatography with 50% ethyl acetate/hexanes to give a white solid (153 mg, 56%). 1H NMR (300 MHz, CDCl3), δ: 7.31 (m, 5H), 7.08 (m, 2H), 6.98 (m, 2H), 5.12 (m, 2H), 5.08 (m, 2H), 4.41 (m, 1H), 3.94 (m, 4H), 3.60 (m, 1H), 3.43 (m, 2H), 2.98 (m, 2H), 2.59 (m, 2H), 2.39 (m, 2H), 1.66 (m, 4H), 1.56 (s, 9H). MS (ESI), m+/z: (M+H)+=554.4.
Part J: Preparation of (3R,4S)-3-amino-4-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidine-1-carboxylic acid t-butyl ester
In a Paar flask charged with palladium hydroxide (20 wt % on carbon, 0.423 g) was added (3R,4S)-3-benzyloxycarbonylamino-4-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidine-1-carboxylic acid t-butyl ester (1.41 g, 2.53 mmol) and methanol (30 mL). The reaction was hydrogenated at 60 psi with vigorous shaking for 65 hours. The reaction mixture was filtered through a bed of celite and then concentrated in vacuo to give a thick oil (1.19 g) which was used without further purification. 1H NMR (300 MHz, CDCl3), δ: 7.06 (m, 4H), 4.45 (m, 2H), 4.21 (m, 2H), 3.81 (m, 2H), 3.62 (m, 2H), 3.23 (m, 2H), 3.08 (m, 1H), 2.67 (m, 2H), 2.45 (m, 2H), 2.21 (m, 1H), 1.45 (s, 9H). MS (APCI), m+/z: (M+H)+=420.3.
Part K: Preparation of (3R,4S)-3-[3-(3-acetyl-phenyl)-ureido]-4-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidine-1-carboxylic acid t-butyl ester
In a dry flask (3R,4S)-3-amino-4-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidine-1-carboxylic acid t-butyl ester (77 mg, 0.18 mmol) was dissolved in tetrahydrofuran (2.5 mL) and triethylamine (20 μL, 0.143 mmol) and 3-acetylphenylisocyanate (50 μL, 0.36 mmol) were added. The reaction mixture was stirred for 16 hours. The reaction mixture was concentrated in vacuo and purified by preparative reverse-phase HPLC (10-90% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (40 mg, 38%). 1H NMR (300 MHz, CDCl3), δ: 7.98 (d, J=8, 1H), 7.83 (m, 2H), 7.74 (m, 1H), 7.65 (m, 2H), 7.56 (m, 1H), 7.46 (m, 1H), 7.01 (m, 2H), 6.87 (m, 1H), 3.09 (m, 1H), 2.51-2.77 (m, 7H), 2.42 (m, 1H), 1.23-1.78 (m, 1H), 1.42 (s, 9H). HRMS (ESI), C32H42FN4O5 m+/z: calc.=581.3139, found=581.3142.
Example 14
Preparation of 1-(3-acetyl-phenyl)-3-{(3R,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidin-3-yl}-urea, trifluoroacetic acid salt
In a dry flask (3R,4S)-3-[3-(3-acetyl-phenyl)-ureido]-4-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidine-1-carboxylic acid t-butyl ester (25 mg, 0.043 mmol) was dissolved in trifluoroacetic acid. The reaction mixture was stirred for 4 hours. The reaction mixture was concentrated in vacuo then purified by preparative reverse-phase HPLC (10-90% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (19 mg, 50%). 1H NMR (300 MHz, CDCl3), δ: 9.25 (bs, 2H), 8.26 (bs, 1H), 7.96 (m, 1H), 7.52 (m, 1H), 7.38 (m, 2H), 7.15 (m, 1H), 6.94 (m, 4H), 4.40 (m, 1H), 4.16 (m, 1H), 3.76 (m, 1H), 3.64 (m, 1H), 3.33 (m, 1H), 3.27 (m, 1H), 3.04 (m, 1H), 2.68 (m, 2H), 2.50 (s, 3H), 2.39 (m, 1H), 1.81 (m, 2H), 1.81 (m, 2H), 1.66 (m, 2H), 1.39 (m, 2H), 1.26 (m, 1H). HRMS (ESI), C27H36FN4O2 m+/z: calc.=481.2615, found=481.2622.
Example 15
Part A: Preparation of (3R,4R)-4-amino-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid t-butyl ester
In a dry flask (3R,4R)-4-amino-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidine-1-carboxylic acid t-butyl ester (500 mg, 1.19 mmol) was dissolved in borane (50 mL of a 1M solution in tetrahydrofuran, 50 mmol). The reaction was stirred 19 hours. The reaction was poured into hydrochloric acid (70 mL of a 1M aqueous solution) and stirred vigorously for 4 hours. The reaction mixture was neutralized with saturated aqueous sodium bicarbonate. The layers were separated and the aqueous layer was extracted with ethyl acetate. The organic layers were combined, dried with magnesium sulfate, filtered and concentrated in vacuo. The mixture was purified by flash chromatography using 5-20% methanol in chloroform to give a yellow solid (371 mg, 77%). 1H NMR (300 MHz, CDCl3), δ: 7.08 (m, 2H), 6.97 (t, 2H, J=8), 4.08 (bs, 2H), 3.70 (bs, 1H), 3.34 (bs, 1H), 3.02 (bt, 1H, J=9), 2.68 (bm, 2H), 2.32 (bm, 7H), 1.98 (m, 1H), 1.75 (m, 5H), 1.44 (s, 9H), 0.89 (m, 1H).
Part B: Preparation of (3R,4R)-4-[3-(3-acetyl-phenyl)-ureidol-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid t-butyl ester, trifluoroacetic acid salt
In a dry flask (3R,4R)-4-amino-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid t-butyl ester (42 mg, 0.103 mmol) was dissolved in tetrahydrofuran (2 mL) and triethylamine (20 μL, 0.143 mmol) and 3-acetylphenylisocyanate (17 μL, 0.124 mmol) were added. The reaction mixture was stirred for 16 hours. The reaction mixture was concentrated in vacuo and purified by preparative reverse-phase HPLC (10-80% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (56 mg, 74%). 1H NMR (300 MHz, CD3OD), δ: 8.04 (s, 1H), 7.64 (d, 1H, J=8), 7.58 (d, 1H, J=8), 7.39 (t, 1H, J=8), 7.18 (m, 2H), 6.99 (t, 2H, J=9), 4.02 (d, 1H, J=12), 3.86 (d, 1H, J=14), 3.62 (s, 4H), 3.53 (d, 2H, J=10), 3.24 (m, 2H), 3.08 (m, 2H), 2.93 (m, 2H), 2.62 (m, 2H), 2.56 (s, 3H), 1.97 (m, 4H), 1.77 (m, 2H), 1.57 (m, 1H), 1.46 (s, 9H), 1.23 (m, 1H). HRMS (ESI), C32H44FN4O4 m+/z: calc.=567.3346, found=567.3352.
Example 16
Preparation of 1-(3-acetyl-phenyl)-3-{(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea, bistrifluoroacetic acid salt
In a dry flask (3R,4R)-4-[3-(3-acetyl-phenyl)-ureido]-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid t-butyl ester (31 mg, 0.055 mmol) was dissolved in dichloromethane (1.5 mL) and trifluoroacetic acid (0.5 mL) was added. The reaction mixture was stirred for 4 hours. The reaction mixture was concentrated in vacuo then purified by preparative reverse-phase HPLC (10-80% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (19 mg, 50%). 1H NMR (300 MHz, CD3OD), δ: 8.06 (s, 1H), 7.62 (m, 2H), 7.38 (m, 2H), 7.14 (m, 2H), 6.95 (t, 2H, J=9), 3.70 (m, 2H), 3.49 (m, 3H), 3.33 (m, 2H), 3.04 (m, 4H), 2.63 (m, 2H), 2.56 (s, 3H), 2.49 (m, 2H), 2.16 (m, 2H), 1.90 (m, 2H), 1.74 (m, 2H), 1.19 (m, 1H). HRMS (ESI), C27H36FN4O2 m+/z: calc.=467.2822, found=467.2822.
Example 17
Preparation of 1-{(3R,4R)-1-acetyl-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-3-(3-acetyl-phenyl)-urea, trifluoroacetic acid salt
In a dry flask 1-(3-acetyl-phenyl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea (55 mg, 0.079 mmol) was dissolved in dichloromethane (2 mL), and then triethylamine (55 μL, 0.39 mmol) and acetyl chloride (10 μL, 0.14 mmol) were added. The reaction mixture was stirred for 21 hours. The reaction mixture was concentrated in vacuo then was purified by preparative reverse-phase HPLC (10-80% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (26 mg, 53%). 1H NMR (400 MHz, DMSO-d6, 60° C.), δ: 8.97 (bs, 1H), 8.79 (s, 1H), 8.01 (s, 1H), 7.63 (d, 1H, J=8), 7.53 (d, 1H, J=8), 7.39 (t, 1H, J=8), 7.20 (m, 2H), 7.08 (t, 2H, J=9), 6.45 (bs, 1H), 4.26 (m, 1H), 3.98 (bm, 2H), 3.61 (m, 2H), 3.47 (m, 2H), 3.26 (bs, 1H), 3.07 (m, 2H), 2.89 (bs, 1H), 2.61 (m, 2H), 2.52 (s, 3H), 2.01 (m, 5H), 1.84 (m, 2H), 1.59 (bm, 3H), 1.12 (m, 1H). HRMS (ESI), C29H38FN4O3 m+/z: calc. 509.2928, found=509.2942.
Example 18
Preparation of 1-(3-acetyl-phenyl)-3-[(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-methanesulfonyl-piperidin-4-yl]-urea, trifluoroacetic acid salt
In a dry flask 1-(3-acetyl-phenyl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea (70 mg, 0.10 mmol) was dissolved in dichloromethane (2 mL), and then triethylamine (140 μL, 1.0 mmol) and methanesulfonyl chloride (8 μL, 0.10 mmol) were added. The reaction mixture was stirred for 2 hours at 0° C. The reaction mixture was quenched with water, concentrated in vacuo then was purified by preparative reverse-phase HPLC (10-80% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (31 mg, 47%). 1H NMR (300 MHz, CD3OD), δ: 8.04 (s, 1H), 7.61 (m, 2H), 7.40 (t, 1H, J=12), 7.18 (m, 2H), 6.99 (t, 2H, J=9), 3.62 (bm, 6H), 3.13 (m, 3H), 2.93 (m, 2H), 2.87 (s, 3H), 2.59 (m, 2H), 2.56 (s, 3H), 2.23 (bs, 1H), 1.98 (bm, 3H), 1.77 (m, 3H), 1.20 (m, 1H) HRMS (ESI), C28H38FN4O4S m+/z: calc. 545.2598, found=545.2591.
Example 19
Preparation of 1-(3-acetyl-phenyl)-3-{(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-methyl-piperidin-4-yl}-urea, bistrifluoroacetic acid salt
In a dry flask 1-(3-acetyl-phenyl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea (83 mg, 0.12 mmol) was dissolved in dichloroethane (5 mL), and then a solution of formaldehyde (240 μL in tetrahydrofuran) was added. The reaction mixture was stirred for 5 minutes then triacetoxyborohydride (41 mg, 0.19 mmol) was added. The mixture was stirred an additional 3 hours. The reaction was quenched with saturated aqueous sodium bicarbonate (1 mL) then diluted with water. The mixture was extracted with dichloromethane three times, dried with magnesium sulfate, filtered and concentrated in vacuo. Then it was purified by preparative reverse-phase HPLC (10-80% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (47 mg, 55%). 1H NMR (300 MHz, CD3OD), δ: 8.07 (s, 1H), 7.62 (m, 2H), 7.40 (t, 1H, J=8), 7.14 (m, 2H), 6.96 (t, 2H, J=9), 3.74 (m, 2H), 3.55 (m, 3H), 3.35 (m, 2H), 3.07 (bm, 4H), 2.90 (s, 3H), 2.65 (m, 2H), 2.56 (s, 3H), 2.47 (m, 1H), 2.05 (bm, 4H), 1.73 (m, 2H), 1.17 (m, 1H). HRMS (ESI), C28H38FN4O2 m+/z: calc. 481.2978, found=481.2986.
Example 20
Preparation of 1-(3-acetyl-phenyl)-3-[(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1-isobutyl-piperidin-4-yl]-urea, bistrifluoroacetic acid salt
In a dry flask 1-(3-acetyl-phenyl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea (97 mg, 0.14 mmol) was dissolved in dichloroethane (5 mL), and i-butyraldehyde (15 μL, 0.165 mmol) was added. The reaction mixture was stirred for 5 minutes then triacetoxyborohydride (46 mg, 0.22 mmol) was added. The mixture was stirred an additional 2 hours. The reaction was quenched with saturated aqueous sodium bicarbonate (1 mL) then diluted with water. The mixture was extracted with dichloromethane three times, dried with magnesium sulfate, filtered and concentrated in vacuo. Then it was purified by preparative reverse-phase HPLC (10-80% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (38 mg, 36%). 1H NMR (300 MHz, CD3OD), δ: 8.07 (s, 1H), 7.61 (m, 2H), 7.41 (m, 1H), 7.14 (m, 2H), 6.96 (m, 2H), 3.90 (bs, 1H), 3.61 (bm, 4H), 3.32 (m, 2H), 3.01 (bm, 6H), 2.62 (m, 2H), 2.56 (s, 3H), 2.49 (bs, 1H), 2.12 (bm, 4H), 1.88 (m, 1H), 1.73 (m, 2H), 1.17 (m, 1H), 1.03 (m, 6H). HRMS (ESI), C31H44FN4O2 m+/z: calc. 523.3448, found=523.3453.
Example 21
Preparation of (3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-4-{3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-ureido}-piperidine-1-carboxylic acid t-butyl ester, trifluoroacetic acid salt
In a dry flask (3R,4R)-4-amino-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid t-butyl ester (43 mg, 0.11 mmol) was dissolved in dimethylformamide (1 mL) and [3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-carbamic acid phenyl ester (36 mg, 0.12 mmol) was added. The reaction mixture was stirred for 16 hours. The reaction mixture was diluted with ethyl acetate and extracted twice with water and once with brine. The combined organic extract was dried with sodium sulfate, filtered and concentrated in vacuo. Half of the resulting oil was purified by preparative reverse-phase HPLC (10-80% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (24 mg, 63%). 1H NMR (300 MHz, CD3OD), δ: 7.98 (s, 1H), 7.52 (m, 2H), 7.42 (m, 1H), 7.17 (m, 2H), 6.99 (t, 2H, J=8), 4.18 (s, 3H), 4.03 (d, 1H, J=14), 3.86 (d, 1H, J 14), 3.64 (td, 1H, J=9, J′=5), 3.54 (d, 2H, J=13), 3.25 (m, 2H), 3.09 (m, 2H), 2.94 (t, 2H, J=10), 2.60 (m, 3H), 2.03 (bs, 2H), 1.94 (d, 2H, J=14), 1.77 (t, 2H, J=11), 1.57 (m, 1H), 1.46 (s, 9H), 1.21 (m, 1H). HRMS (ESI), C32H44FN8O3 m+/z: calc.=607.3521, found=607.3518.
Example 22
Preparation of 1-{(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea, bistrifluoroactetic acid salt
In a dry flask (3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-4-{3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-ureido}-piperidine-1-carboxylic acid t-butyl ester (48 mg, 0.079 mmol) was dissolved in dichloromethane (1.5 mL), and trifluoroacetic acid (0.5 mL) was added. The reaction mixture was stirred for 3 hours. The reaction mixture was concentrated in vacuo then purified by preparative reverse-phase HPLC (10-80% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (22 mg, 38%). 1H NMR (500 MHz, CD3OD, 30° C.), δ: 8.01 (t, 1H, J=1), 7.59 (dq, 1H, J=8, J′=1), 7.52 (t, 1H, J=8), 7.43 (dt, 1H, J=8, J=1), 7.17 (m, 2H), 6.96 (t, 2H, J=9), 4.18 (s, 3H), 3.73 (m, 2H), 3.51 (m, 3H), 3.38 (d, 1H, J=13), 3.13 (m, 2H), 2.99 (m, 2H), 2.64 (dd, 2H, J=14, J′=6), 2.50 (bs, 2H), 2.21 (m, 1H), 2.11 (bs, 1H), 1.92 (m, 2H), 1.76 (m, 2H), 1.19 (m, 1H). HRMS (ESI), C27H36FN8O m+/z: calc. 507.2996, found=507.2976.
Example 23
Preparation of 5-(3-{(3R,4R)-1-t-butoxycarbonyl-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-ureido)-indazole-1-carboxylic acid t-butyl ester, trifluoroacetic acid salt
In a dry flask (3R,4R)-4-amino-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid t-butyl ester (48 mg, 0.118 mmol) was dissolved in dimethylformamide (1 mL) and 5-(phenoxycarbonylamino)-1-indazolecarboxylic acid 1-tert-butyl ester (47 mg, 0.133 mmol) was added. The reaction mixture was stirred for 16 hours. The reaction mixture was diluted with ethyl acetate, washed twice with water and once with brine. The organic layer was dried with magnesium sulfate, filtered and concentrated in vacuo. Half of the crude product was purified by preparative reverse-phase HPLC (10-80% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (26 mg, 57%). 1H NMR (300 MHz, CD3OD), δ: 8.20 (s, 1H) 8.02 (d, 1H, J=9), 7.95 (s, 1H), 7.47 (dd, 1H, J=9, J′=2), 7.17 (m, 2H), 6.99 (t, 2H, J=9), 4.02 (d, 1H, J=10), 3.89 (m, 1H), 3.64 (m, 1H), 3.52 (m, 2H), 3.25 (m, 2H), 3.10 (m, 2H), 2.94 (m, 2H), 2.61 (m, 4H), 1.97 (m, 4H), 1.78 (m, 2H), 1.69 (s, 9H), 1.57 (m, 1H), 1.46 (s, 9H), 1.20 (m, 1H). HRMS (ESI), C36H50FN6O5 m+/z: calc.=665.3827, found=665.3835.
Example 24
Preparation of 5-(3-{(3S,4R)-3-[(S)-3-(4-Fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-ureido)-indazole-1-carboxylic acid t-butyl ester, bistrifluoroacetic acid salt
In a dry flask 5-(3-{(3R,4R)-1-t-butoxycarbonyl-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-ureido)-indazole-1-carboxylic acid t-butyl ester (56 mg, 0.084 mmol) was dissolved in dichloromethane (1.5 mL) and trifluoroacetic acid (0.5 mL) was added. The reaction mixture was stirred for 3 hours. The reaction mixture was concentrated in vacuo then purified by preparative reverse-phase HPLC (10-80% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (29 mg, 43%). 1H NMR (300 MHz, CD3OD), δ: 7.95 (s, 1H), 7.84 (s, 1H), 7.46 (d, 1H, J=9), 7.32 (dd, 1H, J=9, J′=2), 7.13 (m, 2H), 6.95 (t, 2H, J=9), 3.73 (m, 2H), 3.51 (m, 3H), 3.31 (m, 2H), 3.12 (m, 3H), 2.98 (t, 2H, J=12), 2.64 (m, 2H), 2.49 (m, 2H), 2.16 (m, 2H), 1.91 (m, 2H), 1.73 (m, 2H), 1.16 (m, 1H). HRMS (ESI), C26H34FN6O m+/z: calc.=465.2778, found=465.2780.
Example 25
Preparation of (3R,4R)-4-[3-(5-acetyl-4-methyl-thiazol-2-yl)-ureido]-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid t-butyl ester, trifluoroacetic acid salt
In a dry flask (3R,4R)-4-amino-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid t-butyl ester (49 mg, 0.121 mmol) was dissolved in dimethylformamide (1 mL) and 4-acetyl-3-methyl-2-(phenoxycarbonylamino)-thiazole (38 mg, 0.138 mmol) was added. The reaction mixture was stirred for 16 hours. The reaction mixture was diluted with ethyl acetate, washed twice with water and once with brine. The organic layer was dried with magnesium sulfate, filtered and concentrated in vacuo. Half of the crude product was purified by preparative reverse-phase HPLC (10-80% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (18 mg, 42%). 1H NMR (300 MHz, CD3OD), δ: 7.18 (t, 2H, J=8), 7.00 (t, 2H, J=8), 4.01 (d, 1H, J=11), 3.84 (d, 1H, J=14), 3.68 (m, 1H), 3.53 (d, 2H, J=10), 3.16 (bm, 5H), 2.94 (t, 2H, J=10), 2.59 (m, 3H), 2.55 (s, 3H), 2.46 (s, 3H), 2.06 (bs, 2H), 1.91 (m, 2H), 1.77 (m, 2H), 1.59 (m, 1H), 1.46 (s, 9H), 1.23 (m, 1H). HRMS (ESI), C30H43FN5O4S m+/z: calc.=588.3020, found=588.3040.
Example 26
Preparation of 1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea, bistrifluoroacetic acid salt
In a dry flask (3R,4R)-4-[3-(5-acetyl-4-methyl-thiazol-2-yl)-ureido]-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid t-butyl ester (47 mg, 0.080 mmol) was dissolved in dichloromethane (1.5 mL) and trifluoroacetic acid (0.5 mL) was added. The reaction mixture was stirred for 3 hours. The reaction mixture was concentrated in vacuo then purified by preparative reverse-phase HPLC (10-80% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (24 mg, 42%). 1H NMR (300 MHz, CD3OD), δ: 7.15 (m, 2H), 6.98 (t, 2H, J=9), 3.74 (m, 2H), 3.48 (m, 3H), 3.05 (bm, 5H), 2.59 (bm, 4H), 2.56 (s, 3H), 2.46 (s, 3H), 1.94 (bm, 4H), 1.74 (d, 2H, J=13), 1.16 (m, 1H). HRMS (ESI), C25H35FN5O2S m+/z: calc.=488.2499, found=488.2496.
Example 27
Part A: Preparation of (3R,4S)-3-amino-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid t-butyl ester
In a dry flask (3R,4R)-3-[3-(3-acetyl-phenyl)-ureido]-4-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidine-1-carboxylic acid t-butyl ester (1.19 g, 2.84 mmol) was dissolved in borane (100 mL of a 1M solution in tetrahydrofuran, 100 mmol). The reaction was stirred 19 hours. The reaction mixture was concentrated in vacuo and redissolved in 800 mL of ethyl acetate. The solution was poured into hydrochloric acid (140 mL of a 1M aqueous solution) and stirred vigorously for 16 hours. The reaction mixture was neutralized with saturated aqueous sodium bicarbonate. The layers were separated and the aqueous layer was extracted with ethyl acetate. The organic layers were combined, dried with magnesium sulfate, filtered and concentrated in vacuo. The mixture was purified by flash chromatography using 20-0% hexane/ethyl acetate to give a light yellow solid (0.259 g, 22%). 1H NMR (300 MHz, CD3OD), δ: 7.18 (m, 2H), 7.04 (m, 2H), 4.37 (m, 2H), 4.19 (m, 2H), 3.47 (m, 1H), 3.20 (m, 1H), 2.89 (m, 1H), 2.68 (m, 2H), 2.52 (m, 4H), 1.88 (m, 2H), 1.75 (m, 2H), 1.55 (m, 2H), 1.45 (m, 2H), 1.44 (s, 9H). MS (ESI), m+/z: (M+H)+=406.
Part B: Preparation of (3R,4S)-4-[3-(3-acetyl-phenyl)-ureido]-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid t-butyl ester, trifluoroacetic acid salt
In a dry flask (3R,4S)-4-amino-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid t-butyl ester (207 mg, 0.511 mmol) was dissolved in tetrahydrofuran (2 mL) and triethylamine (140 μL, 101 mmol) and 3-acetylphenylisocyanate (68 μL, 0.496 mmol) were added. The reaction mixture was stirred for 16 hours. The reaction mixture was concentrated in vacuo and purified by preparative reverse-phase HPLC (10-80% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (193 mg, 69%). 1H NMR (300 MHz, CD3OD), δ: 8.57 (m, 1H), 8.20 (m, 1H), 7.60 (m, 2H), 6.90 (m, 4H), 4.28 (m, 2H), 3.66 (m, 2H), 3.30 (m, 2H), 2.33-2.61 (m, 12H), 2.02 (m, 2H), 1.79 (m, 2H), 1.65 (m, 2H), 1.46 (s, 9H). HRMS (ESI), C32H44FN4O4 m+/z: calc.=567.3347, found=567.3346.
Example 28
Preparation of 1-(3-acetyl-phenyl)-3-{(3R,4S)-4-δ(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-3-yl}-urea, bistrifluoroacetic acid salt
In a dry flask (3R,4S)-4-[3-(3-acetyl-phenyl)-ureido]-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid t-butyl ester was trifluoroacetic acid (10 mL) was added. The reaction mixture was stirred for 10 minutes. The reaction mixture was concentrated in vacuo then purified by preparative reverse-phase HPLC (10-80% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (13 mg, 38%). 1H NMR (400 MHz, DMSO-d6, 120° C.), δ: 10.02 (bs, 1H), 9.64 (bs, 1H), 9.25 (bs, 1H), 8.20 (s, 1H), 7.93 (bs, 1H), 7.51 (d, J=6, 1H), 7.33 (m, 2H), 6.99 (t, J=6, 2H), 6.88 (t, J=6, 2H), 3.91 (m, 1H), 3.78 (m, 1H), 3.67 (m, 1H), 3.43 (m, 2H), 3.09 (m, 2H), 2.80 (m, 2H), 2.55 (s, 3H), 2.53 (m, 3H), 2.22 (m, 2H), 1.82 (m, 6H), 1.08 (m, 1H). HRMS (ESI), C27H34FN4O3 m+/z: calc.=467.2822, found=467.2828.
Example 29
Part A: Preparation of (3S,4R)-4-[(R)-1-Phenyl-ethylamino]-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester
In a dry flask (3R,4R)-4-[(R)-1-Phenyl-ethylamino]-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester (4.50 g, 12.4 mmol) was dissolved in tetrahydrofuran (170 mL) and t-butanol (11 mL), and sodium t-butoxide (04.85 g, 50.5 mmol)was added. The reaction mixture was stirred for 16 hours. Water was added and the mixture was extracted with ethyl acetate five times. There was minimal residue after concentration in vacuo of the combined organic extracts. The aqueous extract was acidified to pH 3 with 1N hydrochloric acid, saturated with sodium chloride and then extracted five times with ethyl acetate. The combined organic layers were dried with magnesium sulfate, filtered and concentrated in vacuo to give an orange glass (2.11 g, 49%). MS (ESI), m+/z: (M+H)+=349.2.
Part B: Preparation of (3S,4R)-4-amino-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester
In a dry 500-mL Paar flask charged with Palladium hydroxide (20 wt % Pd, dry basis, on carbon, 0.22 g) was added methanol (50 mL) and (3S,4R)-4-[(R)-1-Phenyl-ethylamino]-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester (2.11 g, 6.05 mmol). The reaction mixture was hydrogenated at 53 psi for 42 hours with vigorous shaking. The reaction mixture was filtered through a plug of celite. The plug was washed with 20 mL of ethanol and the combined filtrates were concentrated in vacuo to give a colorless oil (1.32 g, 89%). 1H NMR (300 MHz, CDCl3), δ: 4.38 (bd, J=12, 1H), 4.16 (m, 1H), 3.30 (m, 1H), 2.70 (m, 2H), 1.90-2.40 (m, 5H), 1.45 (s, 9H). MS (ESI), m+/z: (M+H)+=245.1.
Part C: Preparation of (3S,4R)-4-benzyloxycarbonylamino-piperidine-1,3-dicarboxylic acid 1-t-butyl ester
In a dry flask (3S,4R)-4-aminopiperidine-1,3-dicarboxylic acid 1-tert-butyl ester (1.32 g, 5.40 mmol) was dissolved in dichloromethane (30 mL) and triethylamine (1.0 mL, 7.2 mmol) and benzyl chloroformate (0.94 mL, 5.9 mmol) were added. The mixture was stirred for 18 hours. Water (30 mL) was added and the layers separated. The aqueous layer was extracted with dichloromethane (30 mL). The combined organic layers were washed with brine, dried with magnesium sulfate, filtered, and concentrated in vacuo to give a crude oil (2.13 g). Purification by flash column chromatography (5-20% methanol/chloroform) provided a colorless oil (1.29 g, 63%). 1H NMR (400 MHz, DMSO-d6, 120° C.), δ: 7.34 (m, 5H), 6.76 (bs, 1H), 5.04 (s, 2H), 4.01, (bs, 1H), 3.78 (dd, J=14, J′=7, 1H), 3.47 (m, 2H), 3.26 (m, 1H), 2.67 (dt, J=7, J′=4, 1H), 2.49 (m, 1H), 1.79 (m, 1H), 1.59 (m, 1H), 1.40 (s, 9H). MS (ESI), m+/z: (M+Na)+=401.
Part D: Preparation of (3S,4R)-4-benzyloxycarbonylamino-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidine-1-carboxylic acid t-butyl ester
In a dry flask (3S,4R)-4-benzyloxycarbonylamino-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester (0.18 g, 0.48 mmol) was dissolved in dichloromethane (7 mL) and then triethylamine (150 μL, 1.08 mmol) and benzotriazol-1-yloxy-tripyrrolidinophosphonium hexafluorophosphate (0.30 g, 0.58 mmol) were added. The reaction was stirred 18 hours. The reaction mixture was diluted with dichloromethane (25 mL) and extracted twice with water (15 mL). The combined aqueous extracts were extracted with dichloromethane (25 mL). The combined organic extracts were dried with magnesium sulfate, filtered and concentrated in vacuo. The mixture was purified by flash chromatography with 50% ethyl acetate/hexanes to give a white solid (153 mg, 56%). 1H NMR (300 MHz, CDCl3), δ: 7.33 (m, 5H), 7.02 (m, 4H), 5.55 (m, 1H), 5.08 (m, 2H), 4.19-4.48 (m, 1H), 3.96 (bs, 1H), 3.50 (m, 5H), 3.00 (m, 1H), 2.51 (m, 4H), 2.05 (m, 1H), 1.63 (m, 5H), 1.42 (s, 9H), 1.20 (m, 1H). MS (ESI), m+/z: (M+H)+=554.4.
Part E: Preparation of (3S,4R)-4-amino-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidine-1-carboxylic acid t-butyl ester
In a dry 500-mL Paar flask charged with palladium (10 wt % Pd, dry basis, on carbon, 31 mg) was added methanol (10 mL) and (3S,4R)-4-benzyloxycarbonylamino-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidine-1-carboxylic acid t-butyl ester (150 mg, 2.08 mmol). The reaction mixture was hydrogenated at 45 psi for 20.5 hours with vigorous shaking. The reaction mixture was filtered through a plug of celite. The plug was washed with 20 mL of ethanol and the combined filtrates were concentrated in vacuo to give a colorless oil (111 mg, 98%). 1H NMR (300 MHz, CDCl3), δ: 8.75 (bs, 2H), 7.09 (m, 2H), 6.97 (m, 2H), 4.30 (m, !H), 4.01 (m, 2H), 3.70 (m, 2H), 3.25 (m, 1H), 3.10 (m, 1H), 2.75 (m, 1H), 2.48 (m, 4H), 1.82 (m, 5H), 1.42 (s, 9H), 1.21 (m, 2H). MS (ESI), m+/z: (M+H)+=420.3.
Part F: Preparation of (3S,4R)-4-[3-(3-acetyl-phenyl)-ureido]-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidine-1-carboxylic acid t-butyl ester
In a dry flask (3S,4R)-4-amino-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidine-1-carboxylic acid t-butyl ester (43 mg, 0.10 mmol) was dissolved in tetrahydrofuran (2 mL) and then triethylamine (19 μL, 0.14 mmol) and 3-acetylphenylisocyanate (17 μL, 0.12 mmol) were added. After stirring for 18 hours, removed half of the reaction mixture for purification. The remainder of the reaction mixture was taken onto the next reaction without purification. The aliquot was purified by preparative reverse-phase HPLC (10-80% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (17 mg, 57%). 1H NMR (400 MHz, DMSO-d6, 120° C.), δ: 8.64 (s, 1H), 7.94 (m, 1H), 7.57 (d, J=8, 1H), 7.46 (d, J=8, 1H), 7.33 (t, J=8, 1H), 7.17 (m, 2H), 7.00 (t, J=9, 2H), 6.13 (d, J=8, 1H), 4.07 (m, 1H), 3.87 (m, 1H), 3.61 (m, 1H), 3.42 (dd, J=14, J′=4, 1H), 3.32 (m, 1H), 2.98 (m, 2H), 2.70 (m, 1H), 2.50 (m, 1H), 2.49 (s, 3H), 2.02 (m, 1H), 1.73 (m, 3H), 1.53 (m, 1H), 1.39 (s, 9H), 1.22 (m, 2H). HRMS (ESI), C32H42FN4O5 m+/z: calc.=581.3139, found=581.3149.
Example 30
Preparation of 1-(3-acetyl-phenyl)-3-{(3S,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-pipieridin-4-yl}-urea, trifluoroacetic acid salt
In a dry flask (3S,4R)-4-[3-(3-acetyl-phenyl)-ureido]-3-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-piperidine-1-carboxylic acid t-butyl ester (17 mg, 0.029 mmol in 1 mL of tetrahydrofuran) was concentrated in vacuo, redissolved in dichloromethane (1 mL), and trifluoroacetic acid (0.5 mL) was added. The reaction mixture was stirred for 4 hours. The reaction mixture was concentrated in vacuo then purified by preparative reverse-phase HPLC (10-80% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (13 mg, 38%). 1H NMR (400 MHz, DMSO-d6, 120° C.), δ: 8.49 (s, 1H), 8.24 (bs, 2H), 7.93 (s, 1H), 7.58 (d, J=9, 1H), 7.49 (d, J=7, 1H), 7.35 (t, J=8, 1H), 7.12 (t, J=8, 2H), 6.97 (t, J=9, 2H), 6.28 (d, J=8, 1H), 4.17 (m, 1H), 3.83 (m, 1H), 3.46 (bs, 1H), 3.27 (m, 1H), 3.13 (m, 3H), 2.97 (m, 3H), 2.47 (s, 3H), 2.01 (m, 1H), 1.82 (m, 2H), 1.67 (m, 2H), 1.37 (m, 1H), 1.20 (m, 1H). HRMS (ESI), C27H34FN4O3 m+/z: calc.=481.2615, found=481.2632.
Example 31
Preparation of (3R,4R)-4-[3-(3-acetyl-phenyl)-ureido]-3-[(S)3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid methyl ester, trifluoroacetic acid salt
In a dry flask 1-(3-acetyl-phenyl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea (47 mg, 0.07 mmol) was dissolved in dichloromethane (2 mL), and then triethylamine (70 μL, 0.50 mmol) and methyl chloroformate (7 μL, 0.09 mmol) were added. The reaction mixture was stirred for 17 hours. The reaction mixture was concentrated in vacuo then was purified by preparative reverse-phase HPLC (10-80% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (17 mg, 38%). 1H NMR (300 MHz, CD3OD), δ: 8.04 (s, 1H), 7.63 (d, 1H, J=8), 7.57 (d, 1H), J=10), 7.39 (t, 1H, J=8), 7.18 (m, 2H), 6.99 (t, 2H, J=9), 4.05 (d, 1H, J=14), 3.88 (m, 1H), 3.69 (s, 3H), 3.64 (m, 1H), 3.52 (bm, 2H), 3.27 (m, 2H), 3.17-2.89 (m, 4H), 2.64 (m, 2H), 2.56 (s, 3H), 2.08 (bs, 2H), 1.94 (d, 2H, J=14), 1.77 (m, 2H), 1.60 (m, 1H), 1.23 (m, 1H). HRMS (ESI), C29H38FN4O4 m+/z: calc. 525.2877, found=525.2879.
Example 32
Preparation of 1-(3-acetyl-phenyl)-3-{(3R,4R)-1-(2,2-dimethyl-propionyl)-3-[(S)3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea
In a dry flask 1-(3-acetyl-phenyl)-3-{(3R,4R)-3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-piperidin-4-yl}-urea (43 mg, 0.07 mmol) was dissolved in dichloromethane (2 mL), and then triethylamine (65 μL, 0.47 mmol) and pivaloyl chloride (12 μL, 0.10 mmol) were added. The reaction mixture was stirred for 17 hours. The reaction mixture was concentrated in vacuo then was purified by preparative reverse-phase HPLC (10-80% acetonitrile in water with 0.05% trifluoroacetic acid) to give a white amorphous solid (18 mg, 38%). 1H NMR (300 MHz, CD3OD), δ: 8.04 (s, 1H), 7.64 (d, 1H, J=7), 7.58 (dd, 1H, J=7, J′=1), 7.40 (t, 1H, J=8), 7.19 (m, 2H), 6.99 (t, 2H, J=9), 4.27 (d, 1H, J=14), 4.14 (d, 1H, J=15), 3.71 (m, 1H), 3.48 (bm, 3H), 3.25 (m, 2H), 3.07 (m, 1H), 2.95 (m, 2H), 2.66 (m, 2H), 2.57 (s, 3H), 1.98 (m, 4H), 1.76 (m, 2H), 1.62 (m, 1H), 1.28 (s, 9H), 1.20 (m, 1H). HRMS (ESI), C32H44FN4O3 m+/z: calc. 551.3397, found=551.3402.
Example 44
Part A: Preparation of (R)-4-Benzyl-3-[5-(tert-butyl-diphenyl-silanyloxy)-pentanoyl]-oxazolidin-2-one
To a stirring solution of pivaloyl chloride (3.39 mL, 27.5 mmol) and triethylamine (4.39 mL, 31.4 mmol) in dry ether in a flame-dried round bottom flask under N2 at 0° C. was added 5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid prepared according to procedures of Barrett, A. G. M.; et al J. Org. Chem. (1989), 54(14), 3321 (9.35 g, 26.2 mmol). The reaction was warmed to room temperature, and, after 25 min, the white precipitate was removed by filtration. The filtrate was concentrated in vacuo to a colorless oil. The oil was dissolved in dry ether (6 mL) and added via cannula to a solution of lithiated oxazolidinone prepared by treating a solution of oxazolidinone (4.64 g, 26.2 mmol) in dry THF (150 mL) in a flame-dried round bottom flask under N2 at −78° C. with n-butyllithium in hexane (22.4 mL, 1.17 M) until the solution became pale yellow in color. The reaction was stirred for 40 min and then poured into 1N aqueous hydrogen chloride. The reaction was extracted with ethyl acetate (3×150 mL). The organic layers were combined, washed with saturated aqueous sodium bicarbonate, brine, dried over sodium sulfate, and concentrated in vacuo to a colorless oil. The oil was purified by flash chromatography (SiO2, 5-30% ethyl acetate in hexanes) to yield 10.9 g (80.7%) of a white solid. MS (APCI), m+/z: (M+H)+=516.5.
Part B: Preparation of (4R)-4-Benzyl-3-{(2R,3R)-2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-3-hydroxy-5-phenyl-pent-4-enoyl}-oxazolidin-2-one
To a stirring solution of (R)-4-benzyl-3-[5-(tert-butyl-diphenyl-silanyloxy)-pentanoyl]-oxazolidin-2-one (1.64 g, 3.19 mmol) in dry methylene chloride (15.9 mL) in a flame dried round bottom flask under N2 at 0° C. was added titanium(IV) chloride (386 μL, 3.51 mmol). After 5 min, (−)-sparteine (1.83 mL, 7.97 mmol) was added. After 20 min, trans-cinnamaldehyde (442 μL, 3.51 mmol) was added dropwise to the purple suspension, and the resulting pale green-yellow solution was stirred for 1 h. The reaction was quenched by the addition of 50% saturated ammonium chloride (50 mL), diluted with water (100 mL), and then extracted with methylene chloride (3×30 mL). The organic layers were combined, washed with brine, dried over sodium sulfate, and concentrated in vacuo to a colorless oil. The oil was purified by flash chromatography (SiO2, 15-30% ethyl acetate in hexanes) to yield 1.72 g (83.1%) of the desired product as a white solid. MS (APCI), m+/z: (M+H)+=648.
Part C: Preparation of (4R)-4-Benzyl-3-[(2R,3R)-3-hydroxy-2-(3-hydroxy-propyl)-5-phenyl-pent-4-enoyl]-oxazolidin-2-one
To a stirring solution of (4R)-4-benzyl-3-{(2R,3R)-2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-3-hydroxy-5-phenyl-pent-4-enoyl}-oxazolidin-2-one (1.80 g, 2.78 mmol) in pyridine (7.20 mL) in a nalgene vial at 0° C. was added hydrogen fluoride-pyridine (3.6 mL). After 20 min, additional 1 mL aliquots of hydrogen fluoride-pyridine were added to the reaction solution until no starting material was detected by thin-layer chromatography. The reaction was made basic with saturated aqueous sodium bicarbonate, acidified with 6N aqueous hydrogen chloride (100 mL), and washed with ethyl acetate (3×50 mL). The combined organics were dried over sodium sulfate, concentrated in vacuo, and the resulting residue was purified by flash chrom. (SiO2, 50-80% ethyl acetate in hexanes) to give 1.0 g (87.7%) of the desired diol as a foamy white solid. MS (ESI), m+/z: (M+Na)+=432.2.
Part D: Preparation of (4R)-4-Benzyl-3-[(2R,3R)-2-styryl-tetrahydro-pyran-3-carbonyl]-oxazolidin-2-one
To a stirring solution of (4R)-4-benzyl-3-[(2R,3R)-3-hydroxy-2-(3-hydroxy-propyl)-5-phenyl-pent-4-enoyl]-oxazolidin-2-one (3.88 g, 9.49 mmol) in anhydrous methylene chloride (100 mL) in a flame-dried round bottom flask under N2 at −78° C. was added 2,6-lutidine (2.76 mL, 23.7 mmol). Trifluoromethanesulfonic anhydride (1.68 mL, 9.96 mmol) was then added dropwise; after 5 min, the reaction was quenched with saturated aqueous sodium bicarbonate (50 mL), the layers were separated, and the aqueous layer was washed with methylene chloride (2×50 mL). The combined organic layers were dried over sodium sulfate, concentrated in vacuo, and purified by flash chromatography (SiO2, 20-30% ethyl acetate in hexanes) to yield a pale yellow oil. The resulting oil was diluted with ethyl acetate (50 mL), the organic layer was washed once with 1N aqueous hydrogen chloride (50 mL) to remove residual 2,6-lutidine, and the ethyl acetate was concentrated in vacuo to yield the desired tetrahydropyran (2.35 g, 63.3%) as a pale yellow oil. MS (APCI), m+/z: (M+H)+=392.4.
Part E: Preparation of (2R,3R)-2-Styryl-tetrahydro-pyran-3-carboxylic acid
To a stirring solution of (4R)-4-benzyl-3-[(2R,3R)-2-styryl-tetrahydro-pyran-3-carbonyl]-oxazolidin-2-one (177 mg, 0.453 mmol) in 4:1 tetrohydrofuran:water (2.27 mL) at 0° C. was added lithium hydroxide (17.3 mg, 0.724 mmol) dissolved in 900 μL of water. To the resulting solution was added 30 wt % aqueous hydrogen peroxide (205 μL) dropwise, and the now pale yellow solution was stirred for 30 min. The solution was then poured into water (50 mL) containing a 1.5 mL-aliquot of 1.3 M sodium sulfite, and the resulting aqeuous layer was acidified with 6N aqueous hydrogen chloride (10 mL). The aqueous layer was washed with ethyl acetate (3×50 mL), and the combined organic layers were washed with brine (15 mL), dried over sodium sulfate, and concentrated in vacuo. The resulting residue was purified by flash chromatography (SiO2, 33% ethyl acetate in hexanes) to yield the desired product 100 mg (95%) as a pale yellow oil. MS (ESI), m+/z: (M+H)+=233.2.
Part F: Preparation of [(2R,3R)-2-Styryl-tetrahydro-pyran-3-yl]-carbamic acid tert-butyl ester
To a stirring solution of (2R,3R)-2-styryl-tetrahydro-pyran-3-carboxylic acid (106 mg, 0.456 mmol) in anhydrous tert-butanol (5 mL) under nitrogen in a flame-dried round bottom flask was added sequentially triethylamine (95 μL, 0.684 mmol) and diphenylphosphoryl azide (98 μL, 0.456 mmol). The reaction was warmed to reflux conditions and maintained at reflux for 15 h. The reaction solution was then cooled to 23° C., concentrated, and purified by flash chromatography (SiO2, 30% ethyl acetate in hexanes) to yield the desired carbamate (76.4 mg, 55.5%) as a white solid. MS (ESI), m+/z: (M+H)+=304.3.
Part G: Preparation of [(2R,3R)-2-formyl-tetrahydro-pyran-3-yl]-carbamic acid tert-butyl ester
Through a stirring solution of [(2R,3R)-2-styryl-tetrahydro-pyran-3-yl]-carbamic acid tert-butyl ester (27 mg, 0.089 mmol) in methanol (2 mL) at −78° C. was bubbled ozone until the reaction solution was blue in color. Excess triphenylphosine (500 mg) was added, and the reaction was allowed to warm to 23° C. The resulting mixture was concentrated and purified by flash chromatography (SiO2, 7-40% ethyl acetate in hexanes) to give the desired aldehyde (20 mg, 98%) as a pale yellow oil. MS (APCI), m+/z: (M+H)+=230.
Part H: Preparation of {(2S,3R)-2-[(S)-3-(4-Fluoro-benzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-yl}-carbamic acid tert-butyl ester
To a stirring solution of [(2R,3R)-2-formyl-tetrahydro-pyran-3-yl]-carbamic acid tert-butyl ester (20 mg, 0.0873 mmol) in 1,2-dichloroethane (2 mL) in a flame-dried round bottom flask under nitrogen was added (S)-(+)-3-(4-fluorobenzyl)piperidine (R)-mandelate (36.2 mg, 0.105 mmol). To this suspension was added methanol (200 μL), and the resulting solution was treated with sodium triacetoxyborohydride (36 mg, 0.170 mmol). The cloudy yellow suspension was stirred for 15 h and then poured into 1N hydrogen chloride (50 mL). The aqueous layer was basified with 12N aqueous sodium hydroxide and then extracted with ethyl acetate (3×50 mL). The combined organic layers were washed with brine (30 mL), dried over sodium sulfate, and concentrated in vacuo. The resulting residue was purified by flash chromatography to yield the desired carbamic acid (33.1 mg, 93.5%) as a yellow oil. MS (AP+), m+/z: (M+H)+=407.5.
Part I: Preparation of (2S,3R)-2-[(S)-3-(4-Fluoro-benzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-ylamine
To {(2S,3R)-2-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-yl}-carbamic acid tert-butyl ester (33 mg, 0.0813 mmol) was added 4 M hydrogen chloride in dioxane (7 mL). After stirring for one hour, the solution was concentrated in vacuo to give (2S,3R)-2-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-ylamine dihydrochloride as a pale yellow residue (30.8 mg, 100%). This residue was dissolved in ethyl acetate and poured into 1N sodium hydroxide (20 mL). The layers were separated, and the resulting aqueous layer was washed with ethyl acetate (3×50 mL). The combined organic layers were washed with brine (20 mL), dried over sodium sulfate, and concentrated in vacuo to yield (2S,3R)-2-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-ylamine (24.9 mg, 100%) as a pale yellow oil. MS (APCI), m+/z: (M+H)+=307.4.
Part J: Preparation of 1-(3-Acetyl-phenyl)-3-{(2S,3R)-2-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-yl}-urea
To a solution of (2S,3R)-2-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-ylamine dihydrochloride (16 mg, 0.043 mmol—prepared according to Part I) and excess triethylamine (100 μL, 0.719 mmol) in methylene chloride (1 mL) was added 3-acetylphenyl isocyanate (6.9 mg, 0.043) dissolved in methylene chloride (1 mL). The resulting yellow solution was shaken vigorously for 20 sec, and allowed to stand at 23° C. for 10 min. The solution was then concentrated in vacuo, and the resulting residue was purified by flash chromatography (5% methanol in methylene chloride) to yield the desired urea (13 mg, 65%) as a pale yellow oil. MS (ESI), m+/z: (M+H)+=468.3.
Example 45
Preparation of 1-{(2S,3R)-2-[(S)-3-(4-Fluoro-benzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea, trifluoroacetic acid salt
To a stirring solution of (2S,3R)-2-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-ylamine (24 mg, 0.078 mmol) in anhydrous acetonitrile (1 mL) in a flame-dried round bottom flask under nitrogen was added [3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-carbamic acid phenyl ester (22.8 mg, 0.077 mmol). The resulting solution was stirred for 15 h and was then concentrated. Purification of the resulting residue via flash chromatography (5% methanol in dichloromethane) gave 27.3 mg (68%) of a slightly impure off-white solid. This solid was further purified by preparative reverse-phase HPLC (10-90% acetonitrile in water with 0.05% trifluoroacetic acid) to give the desired product (12.7 mg, 31.8%) as an amorphous solid. MS (ESI), m+/z: (M+H—CF3CO2)+=508.4.
Example 46
Preparation of 1-[3-(5-Acetyl-4-methyl-thiazol-2-yl)-phenyl]-3-{(2S,3R)-2-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-yl}-urea
To a stirring solution of (2S,3R)-2-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-ylamine (10 mg, 0.033 mmol) in anhydrous acetonitrile (1 mL) in a flame-dried round bottom flask was added [5-acetyl-4-methyl-thiazol-2-yl)-carbamic acid phenyl ester (11 mg, 0.039 mmol). The resulting solution was stirred for 15 h and was then concentrated. Purification of the resulting residue via flash chromatography (5% methanol in methylene chloride) followed by preparative reverse-phase HPLC (10-90% acetonitrile in water with 0.05% trifluoroacetic acid) gave an amorphous solid. The resulting amorphous solid was dissolved in ethyl acetate (10 mL) and washed with saturated aqueous sodium bicarbonate (20 mL). The aqueous layer was washed with ethyl acetate (10 mL) and the organic layers were combined, dried over sodium sulfate, and concentrated in vacuo to yield the desire product (10.2 mg, 63.8%) as an amorphous solid. MS (APCI), m+/z: (M+H)+=489.6.
Example 47
Part A: Preparation of (2R,3R)-3-tert-Butoxycarbonylamino-tetrahydro-pyran-2-carboxylic acid
To a stirring solution of [(2R,3R)-2-formyl-tetrahydro-pyran-3-yl]-carbamic acid tert-butyl ester (57.7 mg, 0.251 mmol)in methylene chloride (2 mL) was added tetramethyl-ammonium bromide (4.1 mg, 0.012 mmol) and 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical (1 mg, 0.003 mmol), followed by a solution of potassium bromide (3 mg, 0.03 mmol) in water (1 mL). Upon cooling the mixture to 0° C., aqueous sodium hypochlorite (3.6 mL, 0.35 M) made pH 8.6 with sodium bicarbonate (50 mg/mL of 0.35 M NaOCl) was added, and the resulting yellow/orange mixture was stirred vigorously for 5 min. The reaction was poured into 1N aqueous sodium hydroxide (50 mL), acidified with 1N aqueous hydrogen chloride (55 mL), and washed with ethyl acetate (3×50 mL). The combined organic layers were dried over sodium sulfate, concentrated in vacuo, and the resulting residue was purified by flash chromatography (SiO2, 30-50% ethyl acetate in hexanes then 70% ethyl acetate in hexanes containing 5% acetic acid and 1% methanol) to give the desired product (55.5 mg, 89.5%) as a foamy solid. MS (ESI), m−/z: (M−H)−=244.
Part B: Preparation of {(2R,3R)-2-[(S)-3-(4-Fluoro-benzyl)-piperidine-1-carbonyl]-tetrahydro-pyran-3-yl}-carbamic acid tert-butyl ester
To a stirring solution of (2R,3R)-3-tert-butoxy-carbonylamino-tetrahydro-pyran-2-carboxylic acid (55.5 mg, 0.226 mmol) in dichloromethane (2.5 mL) in a flame-dried round bottom flask under nitrogen was added benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate (110 mg, 0.249 mmol) and triethylamine (63 μL, 0.452 mmol). The reaction was allowed to stir for 10 min before the addition of (S)-3-(4-fluoro-benzyl)-piperidine (52.3 mg, 0.271 mmol) in one portion. After an additional 10 min, the solution was poured into saturated aqueous sodium bicarbonate (20 mL), and the aqueous layer was washed with ethyl acetate (3×50 mL). The combined organic layers were washed with saturated aqueous sodium chloride (20 mL), dried over sodium sulfate, and concentrated. The resulting residue was purified by flash chromatography (SiO2, 10-30% ethyl acetate in hexanes) to yield the desired carbamic acid (56 mg, 59%) as a white solid. MS (APCI), m+/z: (M+H)+=421.5.
Part C: Preparation of (2R,3R)-(3-Amino-tetrahydro-pyran-2-yl)-[(S)-3-(4-fluoro-benzyl)-piperidin-1-yl]-methanone hydrochloride
To {(2R,3R)-2-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-tetrahydro-pyran-3-yl}-carbamic acid tert-butyl ester (56 mg, 0.133 mmol) was added 4 M hydrogen chloride in dioxane (10 mL). The resulting pale yellow solution was allowed to stir for 20 min and was then concentrated to give the desired product (43 mg, 100%) as a pale yellow oil. MS (ESI), m+/z: (M+H)+=321.3.
Part D: Preparation of 1-(3-Acetyl-phenyl)-3-{(2R,3R)-2-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-tetrahydro-pyran-3-yl}-urea
To a solution of (2R,3R)-(3-amino-tetrahydro-pyran-2-yl)-[(S)-3-(4-fluoro-benzyl)-piperidin-1-yl]-methanone hydrochloride (14 mg, 0.044 mmol) in dichloromethane (500 μL) containing an excess of triethylamine (100 μL, 0.719 mmol) was added 3-acetylphenyl isocyanate (7.0 mg, 0.044 mmol) in methylene chloride (500 μL). The resulting yellow solution was shaken vigorously for 20 sec and allowed to sit at 23° C. before being concentrated. The resulting residue was purified by flash chormatography (SiO2, 50-90 ethyl acetate in hexanes, then 90% ethyl acetate in hexanes containing 2% methanol) to yield the desired urea (18 mg, 85.3%) as a white solid. MS (ESI), m+/z: (M+H)+=482.6.
Example 48
Preparation of 1-{(2R,3R)-2-[(S)-3-(4-Fluoro-benzyl)-piperidine-1-carbonyl]-tetrahydro-pyran-3-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea
In a single portion was added [3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-carbamic acid phenyl ester (14.2 mg, 0.0481 mmol) in anhydrous acetonitrile (1 mL) to (2R,3R)-(3-amino-tetrahydro-pyran-2-yl)-[(S)-3-(4-fluoro-benzyl)-piperidin-1-yl]-methanone (14 mg, 0.044 mmol) that had been derived from treatment of (2R,3R)-(3-amino-tetrahydro-pyran-2-yl)-[(S)-3-(4-fluoro-benzyl)-piperidin-1-yl]-methanone hydrochloride in ethyl acetate with 1N sodium hydroxide, brine, and concentration in vacuo. The pale yellow solution containing carbamic acid pheny ester and methanone was treated with N,N-dimethylformamide (500 μL) and stirred for 15 hours. Additional carbamic acid phenyl ester (14.2 mg, 0.0481 mmol) was added, the resulting solution was heated for 6 hr at 35° C., and it was then cooled to room temperature. After stirring for an additional 12 hours, the reaction was concentrated and the resulting residue was purified by flash chromatography (45% methylene chloride in ethyl acetate containing 5% methanol) to yield the desired urea (14 mg, 59%) as an off white solid. MS (ESI), m+/z: (M+H)+=522.5.
Example 49
Preparation of 1-[3-(5-Acetyl-4-methyl-thiazol-2-yl)-phenyl]-3-{(2R-3R)-2-[(S)-3-(4-fluoro-benzyl)-piperidine-1-carbonyl]-tetrahydro-pyran-3-yl}-urea
To (2R,3R)-(3-amino-tetrahydro-pyran-2-yl)-[(S)-3-(4-fluoro-benzyl)-piperidin-1-yl]-methanone (15 mg, 0.044 mmol—prepared as in Example 50) in anhydrous acetonitrile (1 mL) was added [5-acetyl-4-methyl-thiazol-2-yl)-carbamic acid phenyl ester (13.3 mg, 0.0481 mmol). The resulting pale yellow solution was stirred for 15 hours, and additional carbamic acid phenyl ester (13.3 mg, 0.0481 mmol) was added as well as N,N-dimethylformamide (500 μL). The resulting cloudy mixture was then heated for 3 hr at 35° C. before being cooled to 23° C. Upon concentration, the resulting residue was purified by flash chromatography (5% methanol in methylene chloride) to yield the desired urea (18 mg, 82%) as a white solid. MS (ESI), m+/z: (M+H)+=503.5.
Example 283
Part A. Preparation of ethyl 4-hydroxybutyric acid ethyl ester
A solution of γ-butyrolactone (86.1 g, 1 mole) in absolute ethanol (1.5 l) was treated with concentrated sulfuric acid (20.4 g, 200 mmol) and stirred at room temperature for 18 h. The mixture was neutralized by slowly adding a solution of sodium metal (9.2 g, 400 mmol) in ethanol (200 mL). The mixture was concentrated in vacuo, and the residue was filtered through celite. The filtrate was distilled through a packed column (0.08 Torr) to provide recovered lactone (bp 27° C., 14.47 g, 17%) and the product as a colorless liquid (bp 52° C., 41.48 g, 31%).
1H NMR (300 mHz, CDCl3) δ 4.14 (q, J=7.0 Hz, 2H), 3.69 (t, J=6.0 Hz, 2H), 2.44 (t, J=6.9 Hz, 2H), 1.89 (m, 3H), 1.27 (t, J=7.0 Hz, 3H).
Part B. Preparation of 4-ethoxycarbonylmethoxybutyric acid ethyl ester
A solution of ethyl 4-hydroxybutyric acid ethyl ester (13.2 g, 100 mmol) and rhodium (II) acetate dimer (440 mg, 1 mmol) in dichloromethane (350 mL) was treated with a solution of ethyl diazoacetate (17.1 g, 150 mmol) in dichloromethane (70 mL) over 4 h. The mixture was stirred at room temperature for 20 h, and concentrated in vacuo. The residue was distilled on a Kugelrohr apparatus (80-90° C., 0.2 Torr) to provide the product as a colorless liquid, contaminated with about 10% by weight of a 1:1 mixture of diethyl maleate and diethyl fumarate (22.02 g, 91%).
1H NMR (300 mHz, CDCl3) δ 4.21 (q, J=7.4 Hz, 2H), 4.13 (q, J=7.0 Hz, 2H), 4.06 (s, 2H), 3.58 (t, J=6.2 Hz, 2H), 2.44 (t, J=7.3 Hz, 2H), 1.94 (m, 2H), 1.29 (t, J=7.3 Hz, 3H), 1.26 (t, J=7.0 Hz, 3H).
Part C. Preparation of 3-oxo-tetrahydro-pyran-4-carboxylic acid ethyl ester
A solution of 4-ethoxycarbonylmethoxybutyric acid ethyl ester (90%, 15.0 g, 61.9 mmol) in toluene (300 mL) was stirred at room temperature and treated over 5 min with a solution of potassium tert-butoxide in tetrahydrofuran (1.0 M, 74.2 mL, 74.2 mmol). The mixture was stirred at room temperature for 24 h, then was poured into 1 N hydrochloric acid. The phases were separated, and the aqueous phase was extracted with ether. The combined organic phases were dried (Na2SO4), filtered and concentrated in vacuo. The residue was purified by flash column chromatography (5% ethyl acetate/hexanes) to provide the product as a pale yellow liquid (5.06 g, 48%).
1H NMR (300 mHz, CDCl3) δ 11.85 (s, 1H), 4.24 (q, J=7.3 Hz, 2H), 4.14 (t, J=1.7 Hz, 2H), 3.79 (t, J=5.5 Hz, 2H), 2.35 (tt, J=5.5, 1.7 Hz, 2H), 1.32 (t, J=7.3 Hz, 3H).
Part D. Preparation of (R)-5-(1-Phenyl-ethylamino)-3,6-dihydro-2H-pyran-4-carboxylic acid ethyl ester
A solution of 3-oxo-tetrahydro-pyran-4-carboxylic acid ethyl ester (3.03 g, 17.6 mmol), R-(+)-α-methylbenzylamine (2.35 g, 19.4 mmol) and p-toluenesulfonic acid hydrate (67 mg, 230 μmol) in benzene (60 mL) was heated at reflux under a Dean-Stark trap for 16 h. The cooled mixture was concentrated in vacuo to provide the product as a yellow oily semisolid (5.05 g), used without further purification.
1H NMR (300 mHz, CDCl3) δ 8.97 (bd, J=7.3 Hz, 1H), 7.3-7.2 (m, 5H), 4.41 (m, 1H), 4.30 (d, J=16.1 Hz, 1H), 4.18 (q, J=7.3 Hz, 2H), 3.91 (d, J=16.1 Hz, 1H), 3.64 (m, 2H), 2.34 (m, 2H), 1.48 (d, J=6.5 Hz, 3H), 1.30 (t, J=7.3 Hz, 3H).
Part E. Preparation of (3S,4R)-3-[(R)-1-Phenyl-ethylamino]-tetrahydro-pyran-4-carboxylic acid ethyl ester
A solution of crude (R)-5-(1-Phenyl-ethylamino)-3,6-dihydro-2H-pyran-4-carboxylic acid ethyl ester (4.53 g, ca. 16.5 mmol) was dissolved in trifluoroacetic acid (45 mL) and treated with triethylsilane (7.9 mL, 49.4 mmol). The mixture was stirred for 17 h and then concentrated. The residue was dissolved in water and adjusted to pH 10 with 50% sodium hydroxide. The mixture was extracted with dichloromethane, and the combined organic phases were dried (Na2SO4) and concentrated. The residue was purified by flash column chromatography (40% diethyl ether/petroleum ether) to provide the product as a colorless oil (1.63 g, 36%).
1H NMR (300 mHz, CDCl3) δ 7.22 (m, 4H), 7.16 (m, 1H), 4.14 (q, J=7.3 Hz, 2H), 3.77 (m, 2H), 3.60 (q, J=7.3 Hz, 1H), 3.23 (m, 1H), 2.83 (m, 2H), 2.31 (m, 1H), 1.77 (m, 2H), 1.24 (m, 6H), ESI MS: (M+H)+=278.1 (100%).
Part F. Preparation of (3S,4R)-3-[(R)-1-Phenyl-ethylamino]-tetrahydro-pyran-4-carboxylic acid
A solution of (3S,4R)-3-[(R)-1-Phenyl-ethylamino]-tetrahydro-pyran-4-carboxylic acid ethyl ester (726 mg, 2.6 mmol) in tetrahydrofuran (6 mL) was treated with 1.0 M sodium hydroxide solution (5.2 mL, 5.2 mmol) and the heterogeneous mixture was stirred at room temperature. After 16 h, the now homogeneous solution was treated with 1.0 M hydrochloric acid (5.2 mL, 5.2 mmol) and concentrated in vacuo. The residue was dissolved in water and lyophilized to provide the product, along with sodium chloride, as a fluffy white solid (943 mg, quantitative), used without further purification.
1H NMR (300 mHz, CDCl3) δ 7.41 (m, 5H), 4.09 (q, J=6.6 Hz, 1H), 3.98 (dd, J=11.7, 4.0 Hz, 1H), 3.77 (m, 1H), 3.33 (m, 1H), 3.08 (m, 2H), 2.37 (m, 1H), 2.19 (m, 1H), 1.79 (m, 1H), 1.61 (d, J=6.6 Hz, 3H), ESI MS: (M+H)+=250.3 (100%).
Part G. Preparation of [(S)-3-(4-Fluoro-benzyl)piperidin-1-yl]-[(3S,4R)-3-((R)-1-phenyl-ethylamino)-tetrahydro-pyran-4-yl]-methanone
(S)-3-(4-fluorobenzyl)-piperidine, mandelic acid salt (1.16 g, 3.35 mmol) was dissolved in 1.0 M sodium hydroxide (30 mL) and extracted with ethyl acetate (4×10 mL). The combined organic phases were dried (Na2SO4) and concentrated in vacuo. The free base was used without further purification.
A cloudy solution of (3S,4R)-3-[(R)-1-Phenyl-ethylamino]-tetrahydro-pyran-4-carboxylic acid (containing sodium chloride; 943 mg, 2.57 mmol) in dichloromethane (25 mL) was treated with benzotriazol-1-yloxy-tripyrrolidinophosphonium hexafluorophosphate (1.61 g, 3.09 mmol) and triethylamine (826 μL, 5.92 mmol) and stirred for 5 minutes. A solution of the (S)-3-(4-fluorobenzyl)-piperidine prepared above in dichloromethane (5 mL) was added and the mixture was stirred at room temperature. After 18 h, the mixture was washed with water and saturated NaHCO3, dried (Na2SO4) and concentrated. The residue was purified by flash column chromatography (75% ethyl acetate/hexanes) to provide the product as a gum (1.10 g, 100%).
1H NMR (300 mHz, CDCl3) δ 7.4-7.3 (m, 5H), 7.12 (m, 2H), 6.99 (t, 2H), 4.55 (bd, 1H), 3.87 (m, 2H), 3.70 (m, 2H), 3.4-2.8 (m, 3H), 2.66 (m, 2H), 2.42 (m, 2H), 2.0-1.1 (m, 9H), 1.34 (d, J=6.6 Hz, 3H), ESI MS: (M+H)+=425.3.
Part H. Preparation of [(S)-3-(4-Fluoro-benzyl)-piperidin-1-yl]-[(3S,4R)-3-aminotetrahydro-pyran-4-yl]-methanone
[(S)-3-(4-Fluoro-benzyl)-piperidin-1-yl]-[(3S,4R)-3-((R)-1-phenyl-ethylamino)-tetrahydro-pyran-4-yl]-methanone (1.10 g, 2.6 mmol), palladium hydroxide (20 weight % on carbon, dry basis; 440 mg) and ethanol (40 mL) were combined in a pressure bottle and shaken under a hydrogen atmosphere (55-60 psig) for 20 h. The mixture was filtered through Celite, and the solids were washed thoroughly with ethanol. The filtrate was concentrated to give the product as a glassy foam (803 mg, 96%), used without further purification.
1H NMR (300 mHz, CD3OD) δ 7.22 (m, 2H), 7.04 (m, 2H), 4.50 and 4.30 (2m, 1H), 4.1-3.6 (3H), 3.5-3.4 (2H), 3.3-2.9 (2H), 2.8-2.4 (4H), 2.0-1.2 (7H), ESI MS: (M+H)+=321.2.
Part I. Preparation of (3S,4S)-4-[(S)-3-(4-Fluoro-benzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-ylamine
[(S)-3-(4-Fluoro-benzyl)-piperidin-1-yl]-[(3S,4R)-3-aminotetrahydro-pyran-4-yl]-methanone (367 mg, 1.14 mmol) was treated with borane-tetrahydrofuran complex in tetrahydrofuran (1.0 M; 46 mL, 46 mmol) and stirred for 20 h. The mixture was treated slowly with 20% acetic acid in methanol (25 mL), and the resulting mixture was stirred at room temperature for 3 h. The solvents were removed, and the residue was dissolved in water, made basic (pH 11) with 50% sodium hydroxide, and extracted with dichloromethane. The combined organic phases were dried (Na2SO4) and concentrated to provide a gum (313 mg). A portion of this material (175 mg) was purified by flash column chromatography (5% methanol/dichloromethane, containing 0.5% ammonium hydroxide) to provide the product (103 mg, 52%) as an oil which solidified on standing.
1H NMR (300 mHz, CD3OD) δ 7.15 (m, 2H), 6.98 (m, 2H), 3.87 (dd, J=10.3, 3.6 Hz, 1H), 3.78 (dd, J=11.1, 4.4 Hz, 1H), 3.37 (dd, J=12.0, 2.4 Hz, 1H), 3.03 (bd, 1H), 3.00 (dd, J=11.0, 10.2 Hz, 1H), 2.78 (bd, 1H), 2.59 (m, 1H), 2.49 (d, J=6.6 Hz, 2H), 2.42 (dd, J=12.8, 8.8 Hz, 1H), 2.23 (dd, J=12.8, 4.4 Hz, 1H), 1.9-1.4 (8H), 1.2 (m, 1H), 1.0 (m, 1H), ESI MS: (M+H)+=307.1.
Part J. Preparation of 1-{(3S,4S)-4-[(S)-3-(4-Fluoro-benzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-yl}-3-[3-methyl-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea, trifluoroacetate salt
(3S,4S)-4-[(S)-3-(4-Fluoro-benzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-ylamine (41 mg, 133 μmol) and [3-methyl-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-carbamic acid phenyl ester (46 mg, 147 μmol) were dissolved in acetonitrile (1 mL) and the mixture was stirred at room temperature. After 24 h, the mixture was concentrated, dissolved in ethyl acetate, washed with water, dried (Na2SO4) and concentrated. The residue was purified by reverse phase high pressure liquid chromatography (C18, 10-100% acetonitrile in water, containing 0.05% trifluoroacetic acid). After isolation, the product was lyophilized to provide a fluffy white solid (32 mg, 38%).
1H NMR (300 mHz, CD3OD) δ 7.79 (s, 1H), 7.39 (s, 1H), 7.25 (s, 1H), 7.19 (m, 2H), 7.00 (m, 2H), 4.18 (s, 3H), 3.90 (m, 2H), 3.6 (m, 3H), 3.5 (m, 1H), 3.2 (m, 1H), 2.94 (bt, 1H), 2.7 (m, 2H), 2.6 (m, 1H), 2.41 (s, 3H), 2.2-1.6 (8H), 1.5 (m, 1H), 1.2 (m, 1H), ESI MS: (M+H)+=522.4.
Example 284
Preparation of 1-{(3S,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea
(3S,4S)-4-[(S)-3-(4-Fluoro-benzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-ylamine (44 mg, 143 μmol) and [3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-carbamic acid phenyl ester (47 mg, 158 μmol) were dissolved in acetonitrile (1 mL) and the mixture was stirred at room temperature. After 24 h, the mixture was concentrated, dissolved in ethyl acetate, washed with water, dried (Na2SO4) and concentrated. The residue was purified by reverse phase high pressure liquid chromatography (C18, 10-100% acetonitrile in water, containing 0.05% trifluoroacetic acid), then by flash column chromatography (5% methanol in dichloromethane, containing 0.5% ammonium hydroxide) to provide the product as a glass (16 mg, 23%).
1H NMR (300 mHz, CD3OD) δ 27.95 (s, 1H), 7.52 (m, 2H), 7.43 (m, 1H), 7.05 (m, 2H), 6.86 (m, 2H), 4.19 (s, 3H), 3.94 (dd, J=10.7, 4.4 Hz, 1H), 3.87 (bd, 1H), 3.50 (td, J=9.9, 4.4 Hz, 1H), 3.39 (m, 1H), 3.09 (t, J=10.2 Hz, 1H), 2.93 (bd, 1H), 2.85 (bd, 1H), 2.56 (dd, J=12.8, 5.2 Hz, 1H), 2.45 (m, 2H), 2.30 (dd, J=12.4, 6.6 Hz, 1H), 2.04 (bt, 1H), 1.9-1.5 (7H), 1.40 (m, 1H), 0.95 (m, 1H), ESI MS: (M+H)+=508.3 (100%).
Example 285
Preparation of 1-{(3S,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-yl}-3-[5-acetyl-4-methylthiazol-2-yl]-urea (3S,4S)-4-[(S)-3-(4-Fluoro-benzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-ylamine (49 mg, 160 μmol) and (5-acetyl-4-methylthiazol-2-yl)-carbamic acid phenyl ester (49 mg, 176 μmol) were dissolved in acetonitrile (1 mL) and the mixture was stirred at room temperature. After 24 h, the mixture was concentrated, dissolved in ethyl acetate, washed with water, dried (Na2SO4) and concentrated. The residue was purified by reverse phase high pressure liquid chromatography (C18, 10-100% acetonitrile in water, containing 0.05% trifluoroacetic acid), then by flash column chromatography (5% methanol in dichloromethane, containing 0.5% ammonium hydroxide) to provide the product as a glass (18 mg, 23%).
1H NMR (300 mHz, CD3OD) δ 7.05 (m, 2H), 6.87 (m, 2H), 3.90 (dd, J=11.0, 4.4 Hz, 1H), 3.84 (m, 1H), 3.53 (td, J=9.5, 4.3 Hz, 1H), 3.40 (bt, 1H), 3.10 (m, 1H), 2.90 (bd, 1H), 2.75 (bd, 1H), 2.58 (s, 3H), 2.48 (s, 3H), 2.45 (m, 3H), 2.21 (dd, J=13.6, 6.3 Hz, 1H), 1.91 (bt, 1H), 1.8-1.5 (7H), 1.37 (m, 1H), 0.92 (m, 1H), ESI MS: (M+H)+=489.4 (100%).
Example 286
Preparation of 1-{(3S,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-yl}-3-(3-acetylphenyl)-urea trifluoroacetate salt
(3S,4S)-4-[(S)-3-(4-Fluorobenzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-ylamine (45 mg, 146 μmol), 3-acetylphenyl isocyanate (20 μL, 146 μmol) and triethylamine (21 μL, 146 μmol) were dissolved in tetrahydrofuran (1 mL) and the mixture was stirred at room temperature. After 22.5 h, the mixture was concentrated. The residue was purified by flash column chromatography (5% methanol in dichloromethane, containing 0.5% ammonium hydroxide), then by reverse phase high pressure liquid chromatography (C18, 10-100% acetonitrile in water, containing 0.05% trifluoroacetic acid) to provide the product as a glass. After lyophilizing the product was a fluffy white powder (42 mg, 49%).
1H NMR (300 mHz, CD3OD) δ 8.09 (t, J=1.9 Hz, 1H), 7.61 (m, 2H), 7.39 (t, J=8.1 Hz, 1H), 7.17 (m, 2H), 6.99 (m, 2H), 3.91 (m, 2H), 3.57 (m, 3H), 3.45 (m, 1H), 3.4-3.2 (m, 2H), 3.12 (dd, J=13.2, 8.2 Hz, 1H), 2.93 (m, 1H), 2.7-2.45 (m, 3H), 2.57 (s, 3H), 2.2-1.7 (m, 6H), 1.50 (m, 1H), 1.20 (m, 1H), ESI MS: (M+H)+=468.5 (100%).
Example 287
Preparation of 1-{(3S,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-yl}-3-(2-morpholin-4-yl-ethyl)-urea bis-trifluoroacetate salt
(3S,4S)-4-[(S)-3-(4-Fluorobenzyl)-piperidin-1-ylmethyl]-tetrahydro-pyran-3-ylamine (44 mg, 144 μmol), (2-morpholin-4-yl-ethyl)-carbamic acid 4-nitro-phenyl ester hydrochloride (58 mg, 173 μmol) and triethylamine (24 μL, 173 mmol) were dissolved in N,N-dimethylformamide (1 mL) and the mixture was stirred at room temperature. After 22.5 h, the mixture was concentrated. The residue was dissolved in ethyl acetate, washed with 1N sodium hydroxide, water, and brine, and dried (Na2SO4) and concentrated. The residue was purified by flash column chromatography (5% methanol in dichloromethane, containing 0.5% ammonium hydroxide), then by reverse phase high pressure liquid chromatography (C18, 10-100% acetonitrile in water, containing 0.05% trifluoroacetic acid) to provide the product as a glass. After lyophilizing the product was a glass (63 mg, 63%).
1H NMR (300 mHz, CD3OD) δ 7.19 (m, 2H), 7.02 (m, 2H), 4.03 (m, 2H), 3.88 (m, 2H), 3.79 (m, 2H), 3.7-3.3 (m, 8H), 3.3-3.0 (m, 7H), 2.92 (m, 1H), 2.7-2.5 (m, 3H), 2.1-1.7 (m, 6H), 1.50 (m, 1H), 1.20 (m, 1H), AP MS: (M+H)+=463.2 (100%).
Example 288
Part A. Preparation of (R)-4-(1-phenyl-ethylamino)-2,5-dihydrothiophene-3-carboxylic acid methyl ester
A solution of 4-oxo-tetrahydrothiophene-3-carboxylic acid methyl ester (prepared according to the procedure of O. Hromatka, D. Binder and K. Eichinger, Monatsheft. Chem. 1973, 104, 1520; 3.20 g, 20 mmol), R-(+)-α-methylbenzylamine (2.85 mL, 22 mmol), acetic acid (2.85 mL, 50 mmol) and benzene (100 mL) was heated at reflux under a Dean-Stark trap for 4.5 h. The cooled mixture was concentrated in vacuo to provide the product as a viscous yellowish oil (6.2 g) which contained residual acetic acid. Ths material, which solidified on standing, was used without further purification.
1H NMR (300 mHz, CDCl3) δ 8.27 (bd, J=7.4 Hz, 1H), 7.35 (m, 2H), 7.25 (m, 3H), 4.54 (m, 1H), 3.87 (m, 1H), 3.82 (m, 2H), 3.75 (s, 3H), 3.54 (m, 1H), 1.54 (d, J=6.6 Hz, 3H).
Part B. Preparation of (3R,4S)-4-[(R)-1-phenyl-ethylamino]-tetrahydrothiophene-3-carboxylic acid methyl ester
A solution of crude (R)-4-(1-Phenyl-ethylamino)-2,5-dihydrothiophene-3-carboxylic acid methyl ester (2.82 g, ca. 9.1 mmol) was dissolved in trifluoroacetic acid (50 mL) and treated with triethylsilane (4.4 mL, 27.4 mmol). The mixture was stirred for 20 h, when TLC indicated residual starting material. Additional triethylsilane (1.5 mL) was added and the mixture was heated at reflux for 3 h, then was cooled and concentrated. The residue was dissolved in water and adjusted to pH 10 with 50% sodium hydroxide. The mixture was extracted with ether, and the combined organic phases were dried (Na2SO4) and concentrated. The residue was purified by flash column chromatography (15-30% diethyl ether/petroleum ether) to provide the product as a colorless oil (673 mg, 28%).
1H NMR (300 mHz, CDCl3) δ 7.33 (m, 4H), 7.27 (m, 1H), 3.84 (q, J=6.6 Hz, 1H), 3.73 (s, 3H), 3.61 (m, 1H), 3.1-3.0 (m, 3H), 2.80 (dd, J=11.0, 5.8 Hz, 1H), 2.54 (dd, J=11.0, 6.6 Hz, 1H), 1.37 (d, J=6.6 Hz, 3H), ESI MS: (M+H)+=266.1.
Part C. Preparation of (3R,4S)-4-[(R)-1-phenyl-ethylamino]-tetrahydrothiophene-3-carboxylic acid
A solution of Preparation of (3R,4S)-4-[(R)-1-phenyl-ethylamino]-tetrahydrothiophene-3-carboxylic acid methyl ester (673 mg, 2.54 mmol) in tetrahydrofuran (5 mL) was treated with 1.0 M sodium hydroxide solution (5.0 mL, 5.0 mmol) and the heterogeneous mixture was stirred at room temperature. After 75 min, the now homogeneous solution was treated with 1.0 M hydrochloric acid (5.0 mL, 5.0 mmol) and concentrated in vacuo. The residue was dissolved in water and lyophilized to provide the product, along with sodium chloride, as a fluffy white solid (928 mg, quantitative), used without further purification.
1H NMR (300 mHz, DMSO-d6) δ 7.4-7.2 (m, 5H), 3.87 (q, J=6.6 Hz, 1H), 3.27 (dd, J=13.6, 7.0 Hz, 1H), 3.0-2.8 (m, 3H), 2.5 (m, 2H), 1.26 (d, J=6.6, 3H), ESI MS: (M+H)+=252.0.
Part D. Preparation of [(S)-3-(4-fluorobenzyl)-piperidin-1-yl]-[(3R,4S)-4-((R)-1-phenyl-ethylamino)-tetrahydrothiophen-3-yl]-methanone
(S)-3-(4-fluorobenzyl)-piperidine, mandelic acid salt (1.14 g, 3.30 mmol) was stirred in ethyl acetate (20 mL) and 1.0 M sodium hydroxide (25 mL) until the solid dissolved. The layers were separated and the organic phase was extracted with ethyl acetate (2×25 mL). The combined organic phases were dried (Na2SO4) and concentrated in vacuo. The free base was used without further purification.
A cloudy solution of (3R,4S)-4-[(R)-1-phenyl-ethylamino]-tetrahydrothiophene-3-carboxylic acid (containing sodium chloride; 928 mg, 2.54 mmol) in dichloromethane (20 mL) was treated with benzotriazol-1-yloxy-tripyrrolidinophosphonium hexafluorophosphate (1.59 g, 3.05 mmol) and triethylamine (814 μL, 5.84 mmol) and stirred for 5 minutes. A solution of the (S)-3-(4-fluorobenzyl)-piperidine prepared above in dichloromethane (5 mL) was added and the mixture was stirred at room temperature. After 21.5 h, the mixture was diluted with dichloromethane, washed with water and saturated NaHCO3, dried (Na2SO4) and concentrated. The residue was purified by flash column chromatography (55% ethyl acetate/hexanes) to provide the product as a gum (1.05 g, 94%).
1H NMR (300 mHz, CDCl3) δ 7.32 (m, 4H), 7.27 (m, 1H), 7.10 (m, 2H), 6.99 (m, 2H), 4.47 (m, 1H), 3.9-3.6 (m, 3H), 3.2 (m, 1H), 2.95 (m, 2H), 2.8-2.4 (m, 6H), 1.9-1.6 (m, 4H), 1.4 (m, 1H), 1.37 (m, 3H), 1.2 (m, 1H), ESI MS: (M+H)+=427.4.
Part E. Preparation of [1,1-dioxo-(3R,4S)-4-[(R)-1-phenyl-ethylamino]-tetrahydrothiophen-3-yl]-[(S)-3-(4-fluorobenzyl)-piperidin-1-yl]-methanone
[(S)-3-(4-fluorobenzyl)-piperidin-1-yl]-[(3R,4S)-4-[(R)-1-phenyl-ethylamino]-tetrahydro-thiophen-3-yl]-methanone (1.02 g, 2.39 mmol) was dissolved in methanol (10 mL) and acetone (10 mL) and stirred on ice. Water (10 mL) was added, and the resulting heterogeneous mixture was treated with potassium peroxymonosulfate (Oxone®, 3.67 g, 5.98 mmol). After 5 min the cooling bath was removed and the mixture was stirred at room temperature. After 20.5 h, the mixture was concentrated and diluted with water. The pH was adjusted to ca. 11 with 1N sodium hydroxide, and the mixture was extracted with ethyl acetate. The combined extracts were dried (Na2SO4) and concentrated, and the residue was purified by flash column chromatography (2.5% 2-propanol/chloroform) to provide the product as a glass (790 mg, 72%).
1H NMR (300 mHz, CDCl3) δ 7.31 (m, 5H), 7.11 (m, 2H), 7.06 (m, 2H), 4.50 (m, 1H), 4.0-3.7 (m, 3H), 3.5-2.9 (m, 5H), 2.7-2.5 (m, 4H), 1.9-1.6 (m, 4H), 1.43 (m, 1H), 1.33 (m, 3H), 1.20 (m, 1H), ESI MS: (M+H)+=459.3.
Part F. Preparation of [(3R,4S)-4-amino-1,1-dioxo-tetrahydrothiophen-3-yl]-[(S)-3-(4-fluorobenzyl)-piperidin-1-yl]-methanone
[1,1-Dioxo-(3R,4S)-4-[(R)-1-phenyl-ethylamino]-tetrahydrothiophen-3-yl]-[(S)-3-(4-fluoro-benzyl)-piperidin-1-yl]-methanone (790 mg, 1.72 mmol), palladium hydroxide (20 weight % on carbon, dry basis; 1.1 g) and methanol (50 mL) were combined in a pressure bottle and shaken under a hydrogen atmosphere (55-60 psig) for 20.5 h. The mixture was filtered through Celite, and the solids were washed thoroughly with methanol. The filtrate was concentrated to give the product as a solid (660 mg, quantitative), used without further purification.
1H NMR (300 mHz, CD3OD) δ 7.20 (m, 2H), 7.00 (m, 2H), 4.45 and 4.32 (2m, 1H), 4.09 (m, 1H), 3.90 and 3.79 (2m, 1H), 3.7-3.4 (m, 2H), 3.13 (m, 2H), 2.87 and 2.69 (2m, 1H), 2.56 (m, 2H), 1.79 (m, 3H), 1.28 (m, 3H), 0.88 (m, 1H), ESI MS: (M+H)+=355.2.
Part G. Preparation of (3S,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-1,1-dioxo-tetrahydro-thiophen-3-ylamine
[(3R,4S)-4-Amino-1,1-dioxo-tetrahydrothiophen-3-yl]-[(S)-3-(4-fluorobenzyl)-piperidin-1-yl]-methanone (560 mg, 1.46 mmol) was treated with borane-tetrahydrofuran complex in tetrahydrofuran (1.0 M; 58 mL, 58 mmol) and stirred for 16.5 h. The mixture was treated slowly with 20% acetic acid in methanol (38 mL), and the resulting mixture was stirred at room temperature for 5.5 h. The solvents were removed, and the residue was dissolved in water, made basic (pH 11) with 50% sodium hydroxide, and extracted with dichloromethane. The combined organic phases were dried (Na2SO4) and concentrated to provide a gum. This was purified by flash column chromatography (4% methanol/dichloromethane, containing 0.4% ammonium hydroxide) to provide the product (304 mg, 61%) as a white solid.
1H NMR (300 mHz, CD3OD) δ 7.13 (m, 2H), 6.96 (m, 2H), 3.36 (m, 3H), 2.87 (m, 3H), 2.78 (m, 1H), 2.56 (m, 1H), 2.49 (m, 2H), 2.40 (m, 2H), 1.95 (m, 1H), 1.8-1.6 (m, 4H), 1.50 (m, 1H), 0.95 (m, 1H), ESI MS: (M+H)+=341.2.
Part H. Preparation of 1-{(3S,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-1,1-dioxo-tetrahydrothiophen-3-yl}-3-[5-acetyl-4-methylthiazol-2-yl]-urea, trifluoroacetate salt
(3S,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-1,1-dioxo-tetrahydrothiophen-3-ylamine (39 mg, 115 μmol) and [5-acetyl-4-methylthiazol-2-yl]-carbamic acid phenyl ester (35 mg, 126 μmol) were dissolved in N,N-dimethylformamide (0.8 mL) and treated with triethylamine (16 μL, 115 μmol). The mixture was stirred at room temperature for 19 h, and then concentrated. The residue was purified by flash column chromatography (3% methanol/dichloromethane containing 0.3% aqueous ammonium hydroxide). After isolation, the product was treated with trifluoroacetic acid (1 drop), dissolved in water/acetonitrile and lyophilized to provide a fluffy white solid (50 mg, 68%).
1H NMR (300 mHz, CD3OD) δ 7.23 (m, 2H), 7.04 (m, 2H), 4.48 (bm, 1H), 3.62 (m, 4H), 3.45 (m, 1H), 3.3 (m, 2H), 3.1 (m, 2H), 2.85 (m, 2H), 2.6 (m, 2H), 2.58 (s, 3H), 2.47 (s, 3H0, 2.20 (m, 1H), 1.9 (m, 3H), 1.25 (m, 1H), ESI MS: (M+H)+=523.3.
Example 289
Preparation of 1-{(3S,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-1,1-dioxo-tetrahydrothiophen-3-yl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea, trifluoroacetate salt
(3S,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-1,1-dioxo-tetrahydrothiophen-3-ylamine (41 mg, 120 μmol) and [3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-carbamic acid phenyl ester (39 mg, 131 μmol) were dissolved in N,N-dimethylformamide (1 mL) and treated with triethylamine (19 μL, 131 μmol). The mixture was stirred at room temperature for 66 h, and then concentrated. The residue was purified by flash column chromatography (3% methanol/dichloromethane containing 0.3% aqueous ammonium hydroxide). After isolation, the product was treated with trifluoroacetic acid (1 drop), dissolved in water/acetonitrile and lyophilized to provide a fluffy white solid (70 mg, 89%).
1H NMR (300 mHz, CD3OD) δ 7.95 (t, J=1.4 Hz, 1H), 7.6-7.4 (3H), 7.10 (m, 2H), 6.95 (m, 2H), 4.33 (q, J=7.7 Hz, 1H), 4.19 (s, 3H), 3.56 (dd, J=13.6, 7.7 Hz, 1H), 3.38 (dd, J=13.5, 8.4 Hz, 1H), 3.05 (m, 2H), 2.79 (m, 2H), 2.7-2.4 (5H), 2.05 (m, 1H), 1.9-1.5 (5H), 0.97 (m, 1H), ESI MS: (M+H)+=542.5.
Example 290
Preparation of 1-{(3S,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-1,1-dioxo-tetrahydrothiophen-3-yl}-3-[3-acetylphenyl]-urea, trifluoroacetate salt
(3S,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-1,1-dioxo-tetrahydrothiophen-3-ylamine (41 mg, 120 μmol) and 3-acetylphenyl isocyanate (16.5 μL, 120 μmol) were dissolved in N,N-dimethylformamide (1 mL) and treated with triethylamine (17 μL, 120 μmol). The mixture was stirred at room temperature for 66 h, and then concentrated. The residue was purified by flash column chromatography (3% methanol/dichloromethane containing 0.3% aqueous ammonium hydroxide). After isolation, the product was treated with trifluoroacetic acid (1 drop), dissolved in water/acetonitrile and lyophilized to provide a fluffy white solid (71 mg, 95%).
1H NMR (300 mHz, CD3OD) δ 8.01 (s, 1H), 7.61 (m, 2H), 7.40 (t, J=8.0 Hz, 1H), 7.09 (m, 2H), 6.92 (m, 2H), 4.32 (q, J=8.0 Hz, 1H), 3.56 (dd, J=9.4, 8.1 Hz, 1H), 3.38 (dd, J=13.6, 7.4 Hz, 1H), 3.03 (m, 2H), 2.79 (m, 2H), 2.7-2.4 (5H), 2.57 (s, 3H), 2.04 (m, 1H), 1.8-1.4 (5H), 0.94 (m, 1H), ESI MS: (M+H)+=502.5.
Example 291
Preparation of 1-{(3S,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-1,1-dioxo-tetrahydrothiophen-3-yl}-3-(2-morpholin-4-yl-ethyl)-urea, bis-hydrochloride salt
(3S,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-1,1-dioxo-tetrahydrothiophen-3-ylamine (47 mg, 137 μmol) and (2-morpholin-4-yl-ethyl)-carbamic acid 4-nitro-phenyl ester hydrochloride (55 mg, 164 μmol) were dissolved in N,N-dimethylformamide (1 mL) and treated with triethylamine (23 μL, 164 μmol). The mixture was stirred at room temperature for 67 h, and then concentrated. The residue was purified by flash column chromatography (3% methanol/dichloromethane containing 0.3% aqueous ammonium hydroxide). After isolation, the product was dissolved in 1N hydrochloric acid and water and lyophilized to provide a fluffy white solid (70 mg, 90%).
1H NMR (300 mHz, CD3OD) δ 7.15 (m, 2H), 6.98 (m, 2H), 4.21 (q, J=8.1 Hz, 1H), 3.68 (m, 4H), 3.49 (dd, J=13.6, 8.1 Hz, 1H), 3.35 (m, 1H), 3.25 (t, J=6.6 Hz, 2H), 2.98 (m, 2H), 2.78 (m, 2H), 2.6-2.4 (11H), 2.07 (m, 1H), 1.9-1.5 (5H), 0.98 (m, 1H), ESI MS: (M+H)+=497.1.
Example 292
Preparation of 1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3R,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidine-1-carbonyl]-1,1-dioxo-tetrahydro-1λ6-thiophen-3-yl}-urea
[(3R,4S)-4-Amino-1,1-dioxo-tetrahydrothiophen-3-yl]-[(S)-3-(4-fluorobenzyl)-piperidin-1-yl]-methanone (50 mg, 141 μmol) and [5-acetyl-4-methylthiazol-2-yl]-carbamic acid phenyl ester (43 mg, 155 μmol) were dissolved in N,N-dimethylformamide (1 mL) and treated with triethylamine (22 μL, 155 μmol). The mixture was stirred at room temperature for 94 h, and then concentrated. The residue was purified by flash column chromatography (4% methanol/dichloromethane containing 0.4% aqueous ammonium hydroxide) to provide a white solid (41 mg, 55%).
1H NMR (300 mHz, CD3OD) δ 7.16 (m, 2H), 6.95 (m, 2H), 4.74 (m, 1H), 4.32 (m, 1H), 4.1-3.8 (m, 2H), 3.6-3.5 (m, 2H), 3.4-3.2 (m, 2H), 3.2-2.8 (m, 2H), 2.54 (s, 3H), 2.5 (m, 2H), 2.46+2.44 (2s, 3H), 1.75 (m, 3H), 1.43 (m, 1H), 1.23 (m, 1H), ESI MS: (M+H)+=537.4.
Example 293
Preparation of 1-{(3R,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidine-1-carbonyl]-1,1-dioxo-tetrahydrothiophen-3-yl}-3-(2-morpholin-4-yl-ethyl)-urea, trifluoroacetate salt
[(3R,4S)-4-amino-1,1-dioxo-tetrahydrothiophen-3-yl]-[(S)-3-(4-fluorobenzyl)-piperidin-1-yl]-methanone (48 mg, 135 μmol) and (2-morpholin-4-yl-ethyl)-carbamic acid 4-nitro-phenyl ester hydrochloride (54 mg, 162 μmol) were dissolved in N,N-dimethylformamide (1 mL) and treated with triethylamine (75 μL, 540 μmol). The mixture was stirred at room temperature for 15 h, and then concentrated. The residue was purified by flash column chromatography (4% methanol/dichloromethane containing 0.4% aqueous ammonium hydroxide), then by reverse-phase preparative HPLC (C18, 10-90% acetonitrile/water containing 0.05% trifluoroacetic acid, 35 min, 35 mL/in). After isolation, the product was dissolved in water and lyophilized to provide a fluffy white solid (35 mg, 41%).
1H NMR (300 mHz, CD3OD) δ 7.24 (m, 2H), 7.00 (m, 2H), 4.70 (m, 1H), 4.42+4.32 (2m, 1H), 4.1-3.4 (12H), 3.3-3.0 (7H), 2.85+2.66 (2m, 1H), 2.57 (m, 2H), 1.9-1.6 (m, 3H), 1.5-1.2 (m, 2H), ESI MS: (M+H)+=511.4.
Example 294
Part A. Preparation of (3R, 4S)-4-[(R)-1-phenyl-ethylamino]-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester
A solution of (3R,4S)-4-[(R)-1-phenyl-ethylamino]-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (prepared according to the procedure of X. Wang, J. F. Espinosa and S. H. Gellman, J. Am. Chem. Soc. 2000, 122, 4821; 107 mg, 295 μmol) in tetrahydrofuran (2 mL) was treated with 1.0 M sodium hydroxide solution (600 μL, 600 μmol) and the heterogenous mixture was stirred at room temperature. After 18 h, the now homogenous solution was treated with 1.0 M hydrochloric acid (600 μL, 600 μmol) and concentrated in vacuo. The residue was dissolved in water and lyophilized to provide the product, along with sodium chloride, as a white solid (115 mg, quantitative), used without further purification.
1H NMR (300 mHz, CD3OD) δ 7.48 (m, 5H), 4.44 (m, 1H), 3.89 (m, 1H), 3.78 (m, 1H), 3.44-3.14 (3H), 1.67 (d, 3H), 1.4 (bs, 9H); mass spec. (ES+) m/z 335.3.
Part B. Preparation of (3R,4S)-3-[(S)-3-(4-fluorobenzyl)-piperidine-1-carbonyl]-4-[(R)-1-phenyl-ethylamino]-pyrrolidine-1-carboxylic acid tert-butyl ester
(S)-3-(4-flourobenzyl)-piperdine, mandelic acid salt (100 mg, 290 μmol) was dissolved in 1.0 M sodium hydroxide (4 mL) and extracted with ethyl acetate (4×5 mL). The combined organic phases were dried (Na2SO4) and concentrated in vacuo. The free base was used without further purification.
A cloudy solution of (3R,4S)-4-[(R)-1-phenyl-ethylamino]-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester (80 mg, 240 μmol) in methylene chloride (5 mL) was treated with benzotriazol-1-yloxy-tripyrrolidinophosphonium hexafluorophosphate (151 mg, 290 μmol) and triethylamine (77 μL, 550 μmol) and stirred for 5 minutes. A solution of the (S)-3-(4-flourobenzyl)-piperdine prepared above in methylene chloride (5 mL) was added and the mixture was stirred at room temperature. After 18 h, the mixture was washed with water and saturated NaHCO3, dried (Na2SO4) and concentrated. The residue was purified by flash column chromatography (50% ethyl acetate/hexanes) to provide the product as a gum (100 mg, 82%).
1H NMR (300 mHz, CD3OD) δ 7.32-6.95 (7H), 4.42-4.30 (1H), 3.90-2.48 (14H), 1.80-1.62 (3H), 1.40 (bs, 9H), 1.29 (d, 3H); mass spec. (ES+) m/z 510.4.
Part C. Preparation of (3S,4R)-3-amino-4-[(S)-3-(4-fluorobenzyl)-piperidine-1-carbonyl]-pyrrolidine-1-carboxylic acid tert-butyl ester
(3R,4S)-3-[(S)-3-(4-fluorobenzyl)-piperidine-1-carbonyl]-4-[(R)-1-phenyl-ethylamino]-pyrrolidine-1-carboxylic acid tert-butyl ester (99 mg, 195 μmol), palladium hydroxide (20 weight % on carbon, dry basis; 40 mg) and ethanol (7 mL) were combined in a pressure bottle and shaken under hydrogen atmosphere (50-55 psig) for 20 h. The mixture was filtered through Celite, and the solids were rinsed with ethanol. The filtrate was concentrated to give the product as a glassy foam (75 mg, 95%), used without further purification.
1H NMR (300 mHz, CDCl3) δ 7.26 (m, 2H), 6.96 (m, 2H), 4.57-4.36 (1H), 3.84-2.41 (10H), 1.93-1.70 (6H), 1.44-1.39 (9H); mass spec. (ES+) m/z 406.4.
Part D. Preparation of (3S,4S)-3-amino-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester
(3S,4R)-3-Amino-4-[(S)-3-(4-fluorobenzyl)-piperidine-1-carbonyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (75 mg, 185 μmol) was treated with borane-tetrahydrofuran complex in tetrahydrofuran (1.0 M; 7.4 mL, 7.4 mmol) and stirred for 20 h. The mixture was treated slowly with 20% acetic acid in methanol (10 mL), and the resulting mixture was stirred at room temperature for 1 h. The solvents were removed, and the residue was dissolved in water, made basic (pH 11) with 50% sodium hydroxide, and extracted with methylene chloride. The combined organic phases were dried (Na2SO4) and concentrated. The residue was purified by flash column chromatography (5% methanol/dichloromethane) to provide the product (30 mg, 40%).
1H NMR (300 mHz, CD3OD) δ 7.20 (m, 2H), 6.98 (m, 2H), 3.18-2.42 (15H), 1.80-1.50 (4H), 1.41 (s, 9H); mass spec. (ES+) m/z 392.4.
Part E. Preparation of (3S,4S)-3-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-4-{3-[3-methyl-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-ureido}-pyrrolidine-1-carboxylic acid tert-butyl ester, trifluoroacetate salt
(3S,4S)-3-amino-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (21 mg, 54 mmol) and [3-methyl-5-(1-methyl-1H-tetrazol-5yl)-phenyl]-carbamic acid phenyl ester (20 mg, 65 μmol) were dissolved in acetonitrile (1 mL) and the mixture was stirred at room temperature. After 24 h, the mixture was concentrated and purified by flash chromatography (5% methanol/dichloromethane containing 0.5% ammonium hydroxide). After isolation, the product was dissolved in water with a small amount of trifluoroacetic acid and the solution was lyophilized to provide a white solid (10 mg, 31%).
1H NMR (300 mHz, CD3OD) δ 7.79 (s, 1H), 7.39 (s, 1H), 7.21 (s, 1H), 7.15-6.94 (4H), 4.19 (s, 3H), 4.02 (m, 1H), 3.76-3.6 (3H), 3.21-2.82 (7H), 2.50 (m, 2H), 2.41 (s, 3H), 2.36 (m, 1H), 1.80-1.60 (5H), 1.45 (s, 9H); mass spec. (ES+) m/z 607.4.
Example 295
Preparation of 1-(5-acetyl-4-methylthiazol-2-yl)-3-{(3S,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-pyrrolidin-3-yl}-urea, bis-trifluoroacetate salt
Part A. Preparation of (3S,4S)-3-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-4-[(R)-1-phenyl-ethylamino]-pyrrolidine-1-carboxylic acid tert-butyl ester
(3R,4S)-3-[(S)-3-(4-fluorobenzyl)-piperidine-1-carbonyl]-4-[(R)-1-phenyl-ethylamino]-pyrrolidine-1-carboxylic acid tert-butyl ester (150 mg, 294 μmol)) was treated with borane-tetrahydrofuran complex in tetrahydrofuran (1.0 M; 11.64 mL, 11.64 mmol) and stirred for 20 h. The mixture was treated slowly with 20% acetic acid in methanol (20 mL), and the resulting mixture was stirred at room temperature for 36 h. The solvents were removed, and the residue was dissolved in water, made basic (pH 11) with 50% sodium hydroxide, and extracted with dichloromethane. The combined organic phases were dried (Na2SO4) and concentrated. The residue was purified by flash column chromatography (60% ethyl acetate/hexane) to provide the product (100 mg, 68%).
1H NMR (300 mHz, CD3OD) δ 7.31-7.00 (9H), 3.78 (m, 1H), 3.42 (m, 1H), 3.22-1.62 (18H), 1.39 (d, 3H), 1.34 (s, 9H); mass spec. (ES+) m/z 496.5.
Part B. Preparation of (3S,4S)-3-amino-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester
(3S,4S)-3-[(S)-3-(4-Fluorobenzyl)-piperidin-1-ylmethyl]-4-[(R)-1-phenyl-ethylamino]-pyrrolidine-1-carboxylic acid tert-butyl ester (100 mg, 0.201 mmol), palladium hydroxide (20 weight % on carbon, dry basis; 40 mg) and methanol (7 mL) were combined in a pressure bottle and shaken under hydrogen atmosphere (50-55 psig) for 20 h. The mixture was filtered through Celite, and the solids were rinsed with ethanol. The filtrate was concentrated to give the product as a glassy foam (75 mg, 95%), used without further purification.
1H NMR (300 mHz, CD3OD) δ 7.20 (m, 2H), 6.98 (m, 2H), 3.18-2.42 (15H), 1.80-1.50 (4H), 1.41 (s, 9H); mass spec. (ES+) m/z 392.4.
Part C. Preparation of 1-(5-acetyl-4-methylthiazol-2-yl)-3-{(3S,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-pyrrolidin-3-yl}-urea, bis-trifluoroacetate salt
(3S,4S)-3-Amino-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (21 mg, 0.054 mmol) and [5-acetyl-4-methylthiazol-2-yl]-carbamic acid phenyl ester (18 mg, 0.065 mmol) were dissolved in DMF (1 mL) and treated with triethylamine (9 μL, 0.065 mmol) and the mixture was stirred at room temperature. After 24 h, the mixture was concentrated and purified by flash column chromatography (5% methanol/dichloromethane containing 0.5% ammonium hydroxide). After isolation, the product was stirred in trifluoroacetic acid for 4 h. The mixture was oncentrated and the residue dissolved in water and lyophilized to provide a white solid (10 mg, 31%).
1H NMR (300 mHz, CD3OD) δ 7.46-7.22 (4H), 4.19-3.40 (4H), 2.61 (s, 3H), 2.45 (s, 3H), 2.24 (m, 1H), 1.64-1.23 (15H); mass spec. (ES+) m/z 474.5.
The compounds shown below were made using the procedures described above.







TABLE 1















































































Ex #
Core
Y
R
MS m/z





1
a
NBoc
3-Ac—Ph
581


2
a
NH
3-Ac—Ph
481


3
a
NBoc
3-(1-Me-5-tetrazole)-Ph
621


4
a
NH
3-(1-Me-5-tetrazole)-Ph
521


5
a
NCOtBu
3-(1-Me-5-tetrazole)-Ph
605


6
a
NAc
3-(1-Me-5-tetrazole)-Ph
563


7
a
NSO2Me
3-(1-Me-5-tetrazole)-Ph
599


8
a
NMe
3-(1-Me-5-tetrazole)-Ph
535


9
a
NBoc
1-Boc-5-indazole
679


10
a
NH
5-indazole
479


11
a
NBoc
5-Ac-4-Me-2-thiazole
602


12
a
NH
5-Ac-4-Me-2-thiazole
502


13
c
NBoc
3-Ac—Ph
581


14
c
NH
3-Ac—Ph
481


15
b
NBoc
3-Ac—Ph
567


16
b
NH
3-Ac—Ph
467


17
b
NAc
3-Ac—Ph
509


18
b
NS2Me
3-Ac—Ph
545


19
b
NMe
3-Ac—Ph
481


20
b
NiBu
3-Ac—Ph
523


21
b
NBoc
3-(1-Me-5-tetrazole)-Ph
607


22
b
NH
3-(1-Me-5-tetrazole)-Ph
507


23
b
NBoc
1-Boc-5-indazole
665


24
b
NH
5-indazole
485


25
b
NBoc
5-Ac-4-Me-2-thiazole
588


26
b
NH
5-Ac-4-Me-2-thiazole
488


27
d
NBoc
3-Ac—Ph
567


28
d
NH
3-Ac—Ph
467


29
g
NBoc
3-Ac—Ph
581


30
g
NH
3-Ac—Ph
481


31
b
NCO3Me
3-Ac—Ph
525


32
b
NCOtBu
3-Ac—Ph
551


33
c
NBoc
3-(1-Me-5-tetrazole)-Ph
621


34
b
NCH2CH2F
3-Ac—Ph
513


35
b
NCH2COMe
3-Ac—Ph
523


36
d
NMe
3-Ac—Ph
481


37
d
NAc
3-Ac—Ph
509


38
b
NAc
3-(1-Me-5-tetrazole)-Ph
549


39
b
NMe
3-(1-Me-5-tetrazole)-Ph
521


40
b
NSO2Me
3-(1-Me-5-tetrazole)-Ph
584


41
a
NCH2COMe
3-(1-Me-5-tetrazole)-Ph
577


42
a
NCH2CH2F
3-(1-Me-5-tetrazole)-Ph
567


43
a
NSO23
3-(1-Me-5-tetrazole)-Ph
653


44
f
O
3-Ac—Ph
468


45
f
O
3-(1-Me-5-tetrazole)-Ph
653


46
f
O
5-Ac-4-Me-2-thiazole
489


47
e
O
3-Ac—Ph
482


48
e
O
3-(1-Me-5-tetrazole)-Ph
522


49
e
O
5-Ac-4-Me-2-tetrazole)-Ph
503


50
b
NMe
5-Ac-4-Me-2-thiazole
502


51
b
NAc
5-Ac-4-Me-2-thiazole
530


52
b
NCOi-Pr
5-Ac-4-Me-2-thiazole
558


53
b
NSO2Me
5-Ac-4-Me-2-thiazole
566


54
b
NCH2CH2F
5-Ac-4-Me-2-thiazole
534


55
b
NCH2COMe
5-Ac-4-Me-2-thiazole
544


56
b
O
3-Ac—Ph
468


57
b
O
3-(1-Me-5-tetrazole)-Ph
508


58
b
O
5-Ac-4-Me-2-thiazole
467


59
a
O
3-Ac—Ph
482


60
a
O
3-(1-Me-5-tetrazole)-Ph
522


61
a
O
5-Ac-4-Me-2-thiazole
503


62
b
NH
4-F—Ph
443


63
b
NBoc
4-F—Ph
543


64
b
NAc
4-F—Ph
485


65
b
NMe
4-F—Ph
457


66
b
NEt
4-F—Ph
471


67
b
NCH2[1,2,4]oxadiazol-3-yl
4-F—Ph
525


68
b
NCH2CONHiPr
4-F—Ph
542


69
b
NCH2C≡CH
4-F—Ph
481


70
b
N-piperidin-4-yl
3-Ac—Ph
550


71
b
N-1-Ac-piperidin-4-yl
3-Ac—Ph
592


72
b
N-1-Me-piperidin-4-yl
3-Ac—Ph
564


73
b
NH
3,5-diAc—Ph
509


74
b
NBoc
3,5-diAc—Ph
609


75
b
NAc
3,5-diAc—Ph
551


76
b
NMe
3,5-diAc—Ph
523


77
b
NEt
3,5-diAc—Ph
537


78
b
NCH2[1,2,4]oxadiaz
3,5-diAc—Ph
591


79
b
NCH2CONHiPr
3,5-diAc—Ph
608


80
b
NCH2C≡CH
3,5-diAc—Ph
547


81
b
NCO2Me
3-(1-Me-5-tetrazole)-Ph
565


82
b
NH
3-Me-5-(1-Me-5-tetrazole)-Ph
521


83
b
NBoc
3-Me-5-(1-Me-5-tetrazole)-Ph
621


84
b
NAc
3-Me-5-(1-Me-5-tetrazole)-Ph
563


85
b
NMe
3-Me-5-(1-Me-5-tetrazole)-Ph
535


86
b
NEt
3-Me-5-(1-Me-5-tetrazole)-Ph
549


87
b
NCH2[1,2,4]oxadiazol-3-yl
3-Me-5-(1-Me-5-tetrazole)-Ph
603


88
b
NCH2CONHiPr
3-Me-5-(1-Me-5-tetrazole)-Ph
620


89
b
NCH2C≡CH
3-Me-5-(1-Me-5-tetrazole)-Ph
559


90
b
NH
3-Br-5-(1-Me-5-tetrazole)-Ph
585


91
b
NBoc
3-Br-5-(1-Me-5-tetrazole)-Ph
685


92
b
NAc
3-Br-5-(1-Me-5-tetrazole)-Ph
627


93
b
NMe
3-Br-5-(1-Me-5-tetrazole)-Ph
599


94
b
NEt
3-Br-5-(1-Me-5-tetrazole)-Ph
613


95
b
NCH2[1,2,4]oxadiazol-3-yl
3-Br-5-(1-Me-5-tetrazole)-Ph
667


96
b
NCH2CONHiPr
3-Br-5-(1-Me-5-tetrazole)-Ph
684


97
b
NCH2C~CH
3-Br-5-(1-Me-5-tetrazole)-Ph
623


98
b
NCH2COCH3
3-(5-Me-1-tetrazole)-Ph
563


99
b
NCH2COCH3
1-Me-pyrazol-3-yl
485


100
b
NCH2COCH3
thiazol-2-yl
488


101
b
NCH2COCH3
4-Me-5-CO2Et-thiazol-2-yl
574


102
b
NCO2Me
5-Ac-4-Me-2-thiazole
546


103
b
NCO2CH2CMe2CH2OH
5-Ac-4-Me-2-thiazole
618


104
b
NCOEt
5-Ac-4-Me-2-thiazole
544


105
b
NCO-cyclopropyl
5-Ac-4-Me-2-thiazole
556


106
b
NCO-cyclopentyl
5-Ac-4-Me-2-thiazole
584


107
b
NCO-4-tetrahydropyran
5-Ac-4-Me-2-thiazole
600


108
b
NCOCH2OMe
5-Ac-4-Me-2-thiazole
560


109
b
NCOCH2NMe2
5-Ac-4-Me-2-thiazole
573


110
b
NCONHNe
5-Ac-4-Me-2-thiazole
545


111
b
NCONMe2
5-Ac-4-Me-2-thiazole
559


112
b
NCONHEt
5-Ac-4-Me-2-thiazole
559


113
b
NEt
5-Ac-4-Me-2-thiazole
516


114
b
NPr
5-Ac-4-Me-2-thiazole
530


115
b
NiPr
5-Ac-4-Me-2-thiazole
530


116
b
N-cyclobutyl
5-Ac-4-Me-2-thiazole
542


117
b
N-cyclopentyl
5-Ac-4-Me-2-thiazole
556


118
b
N-4-tetrahydropyran
5-Ac-4-Me-2-thiazole
572


119
b
N-4-tetrahydropyran
5-Ac-4-Me-2-thiazole
588


120
b
N-4-tetrahydropyran-dioxide
5-Ac-4-Me-2-thiazole
620


121
b
N-4-piperidine
5-Ac-4-Me-2-thiazole
571


122
b
N-4-piperidinyl-Boc
5-Ac-4-Me-2-thiazole
671


123
b
N-4-piperidinyl-Ac
5-Ac-4-Me-2-thiazole
613


124
b
N-4-piperidinyl-Me
5-Ac-4-Me-2-thiazole
585


125
b
NCH2-cyclopropyl
5-Ac-4-Me-2-thiazole
542


126
b
NCH2-cyclobutyl
5-Ac-4-Me-2-thiazole
556


127
b
NCH2Ph
5-Ac-4-Me-2-thiazole
578


128
b
NCH2-2-furan
5-Ac-4-Me-2-thiazole
572


129
b
NCH2-3-furan
5-Ac-4-Me-2-thiazole
572


130
b
NCH2-2-thiophene
5-Ac-4-Me-2-thiazole
584


131
b
NCH2-3-thiophene
5-Ac-4-Me-2-thiazole
584


132
b
NCH2-2-imidazole
5-Ac-4-Me-2-thiazole
568


133
b
NCH2-4-imidazole
5-Ac-4-Me-2-thiazole
568


134
b
NCH2-2-thiazole
5-Ac-4-Me-2-thiazole
585


135
b
NCH2[1,2,4]oxadiazol-3-yl
5-Ac-4-Me-2-thiazole
570


136
b
NCH2CH2OH
5-Ac-4-Me-2-thiazole
532


137
b
NCH2CMe2OH
5-Ac-4-Me-2-thiazole
560


138
b
NCH2CHOHCF3
5-Ac-4-Me-2-thiazole
600


139
b
NCH2CH2OMe
5-Ac-4-Me-2-thiazole
546


140
b
NCH2CH2OEt
5-Ac-4-Me-2-thiazole
560


141
b
NCH2CH2SEt
5-Ac-4-Me-2-thiazole
576


142
b
NCH2CH2SO2Et
5-Ac-4-Me-2-thiazole
608


143
b
NCH2CH2OAc
5-Ac-4-Me-2-thiazole
574


144
b
NCH2CN
5-Ac-4-Me-2-thiazole
527


145
b
NCH2CH2NMe2
5-Ac-4-Me-2-thiazole
559


146
b
NCH2CH2NEt2
5-Ac-4-Ne-2-thiazole
587


147
b
NCH2CH2pyrrolidine
5-Ac-4-Me-2-thiazole
585


148
b
NCH2CH2morpholine
5-Ac-4-Me-2-thiazole
601


149
b
NCH2CH2pyrrole
5-Ac-4-Me-2-thiazole
581


150
b
NCH2CH2COMe
5-Ac-4-Me-2-thiazole
558


151
b
NCH2CHMeCOMe
5-Ac-4-Me-2-thiazole
572


152
b
NCH2CH2CH2OH
5-Ac-4-Me-2-thiazole
546


153
b
(R)-NCH2CHMeCH2OH
5-Ac-4-Me-2-thiazole
560


154
b
(S)-NCH2CHMeCH2OH
5-Ac-4-Me-2-thiazole
560


155
b
NCH2COtBu
5-Ac-4-Me-2-thiazole
586


156
b
NCH2CONHMe
5-Ac-4-Me-2-thiazole
559


157
b
NCH2CONHiPr
5-Ac-4-Me-2-thiazole
587


158
b
NCH2CONHtBu
5-Ac-4-Me-2-thiazole
601


159
b
NCH2CONMe2
5-Ac-4-Ne-2-thiazole
573


160
b
N-2-oxocyclopentane
5-Ac-4-Me-2-thiazole
570


161
b
N-allyl
5-Ac-4-Me-2-thiazole
528


162
b
N-propargyl
5-Ac-4-Me-2-thiazole
526


163
d
NH
4-F—Ph
443


164
d
NAc
4-F—Ph
485


165
d
NCOCH2OMe
4-F—Ph
515


166
d
NCH2cyclopropyl
4-F—Ph
497


167
d
NCH2CH2OH
4-F—Ph
487


168
d
NCOCH2OMe
3-Ac—Ph
539


169
d
NCOCH2NMe2
3-Ac—Ph
552


170
d
NCONHEt
3-Ac—Ph
538


171
d
NCH2CH2OH
3-Ac—Ph
511


172
d
NCO2tBu
3-(1-Me-5-tetrazole)-Ph
607


173
d
NAc
3-(1-Me-5-tetrazole)-Ph
549


174
d
NCOtBu
3-(1-Me-5-tetrazole)-Ph
591


175
d
NMe
3-(1-Me-5-tetrazole)-Ph
520


176
d
NH
3-Me-5-(1-Me-5-tetrazole)-Ph
521


177
d
NCH2CH2OH
3-Me-5-(1-Me-5-tetrazole)-Ph
565


178
d
NH
3-Br-5-(1-Me-5-tetrazole)-Ph
584


179
d
NCH2CH2OH
3-Br-5-(1-Me-5-tetrazole)-Ph
629


180
d
NAc
3-(5-Me-1-tetrazole)-Ph
549


181
d
NAc
1-Me-pyrazol-3-yl
471


182
d
NAc
thiazol-2-yl
474


183
d
NAc
4-Me-5-CO2Et-thiazol-2-yl
560


184
d
NH
5-Ac-4-Me-2-thiazole
488


185
d
NCO2Me
5-Ac-4-Me-2-thiazole
546


186
d
NCO2tBu
5-Ac-4-Me-2-thiazole
588


187
d
NAc
5-Ac-4-Me-2-thiazole
530


188
d
NCOEt
5-Ac-4-Me-2-thiazole
544


189
d
NCOiPr
5-Ac-4-Me-2-thiazole
558


190
d
NCOtBu
5-Ac-4-Me-2-thiazole
572


191
d
NCO-cyclopropyl
5-Ac-4-Me-2-thiazole
556


192
d
NCO-cyclobutyl
5-Ac-4-Me-2-thiazole
570


193
d
NCO-cyclopentyl
5-Ac-4-Me-2-thiazole
584


194
d
NCO-cyclohexyl
5-Ac-4-Me-2-thiazole
598


195
d
NCO-4-tetrahydropyran
5-Ac-4-Me-2-thiazole
600


196
d
NCOCH2OMe
5-Ac-4-Me-2-thiazole
560


197
d
NCOCH2Me2
5-Ac-4-Me-2-thiazole
573


198
d
NCONHMe
5-Ac-4-Me-2-thiazole
545


199
d
NCONHEt
5-Ac-4-Me-2-thiazole
559


200
d
NCONHPr
5-Ac-4-Me-2-thiazole
573


201
d
NCONHiPr
5-Ac-4-Me-2-thiazole
573


202
d
NCONH-allyl
5-Ac-4-Me-2-thiazole
571


203
d
NCONH-(5-Ac-4-Me-thiazol-2-yl
5-Ac-4-Me-2-thiazole
670


204
d
NMe
5-Ac-4-Me-2-thiazole
502


205
d
N-4-piperidine
5-Ac-4-Me-2-thiazole
571


206
d
N-4-piperidinyl-Ac
5-Ac-4-Me-2-thiazole
613


207
d
N-4-piperidinyl-Me
5-Ac-4-Me-2-thiazole
585


208
d
NCH2-cyclopropyl
5-Ac-4-Me-2-thiazole
542


209
d
NCH2-2-tetrahydropyran
5-Ac-4-Me-2-thiazole
586


210
d
NCH2-2-furan
5-Ac-4-Me-2-thiazole
568


211
d
NCH2-3-furan
5-Ac-4-Me-2-thiazole
568


212
d
NCH2[1,2,4]oxadiazol-3-yl
5-Ac-4-Me-2-thiazole
570


213
6
NCH2CH2F
5-Ac-4-Me-2-thiazole
534


214
d
NCH2CH2OH
5-Ac-4-Me-2-thiazole
532


215
d
NCH2CH2SO2Et
5-Ac-4-Me-2-thiazole
608


216
d
NCH2CN
5-Ac-4-Me-2-thiazole
527


217
d
NCH2CH2CH2OH
5-Ac-4-Me-2-thiazole
546


218
6
(R)-NCH2CHMeCH2OH
5-Ac-4-Me-2-thiazole
560


219
6
(S)-NCH2CHMeCH2OH
5-Ac-4-Me-2-thiazole
560


220
d
NCH2COMe
5-Ac-4-Me-2-thiazole
544


221
d
NCH2CONMe2
5-Ac-4-Me-2-thiazole
573


222
a
NCOiPr
3-(5-Me-1-tetrazole)-Ph
591


223
a
NCOPh
3-(5-Me-1-tetrazole)-Ph
625


224
a
NSO2iPr
3-(5-Me-1-tetrazole)-Ph
627


225
d
NH
CH2CH2-morpholin-1-yl
462


226
6
NCO2Me
CH2CH2-morpholin-1-yl
520


227
6
NAc
CH2CH2-morpholin-1-yl
504


228
6
NCOEt
CH2CH2-morpholin-1-yl
518


229
d
NCOtBu
CH2CH2-morpholin-1-yl
546


230
d
NCO-cyclobutyl
CH2CH2-morpholin-1-yl
544


231
d
NCO-4-tetrahydropyran
CH2CH2-morpholin-1-yl
574


232
d
NCOCH2OMe
CH2CH2-morpholin-1-yl
534


233
d
NCONMe2
CH2CH2-morpholin-1-yl
533


234
d
NCONHEt
CH2CH2-morpholin-1-yl
533


235
d
NSO2Me
CH2CH2-morpholin-1-yl
540


236
d
NMe
CH2CH2-morpholin-1-yl
476


237
d
NEt
CH2CH2-morpholin-1-yl
490


238
d
NiPr
CH2CH2-morpholin-1-yl
504


239
d
NCH2cPr
CH2CH2-morpholin-1-yl
516


240
d
NCH2COMe
CH2CH2-morpholin-1-yl
518


241
6
O
3-(5-Me-1-tetrazole)-Ph
508


242
d
O
3-Me-5-(1-Me-5-tetrazole)-Ph
522


243
d
O
5-Ac-4-Me-2-thiazole
489


244
b
NCO2Me
4-F—Ph
501


245
b
COCH2NMe2
4-F—Ph
528


246
b
NSO2Me
4-F—Ph
521


247
b
NCH2-thiazol-2-yl
4-F—Ph
540


248
b
NCH2CH2OH
4-F—Ph
487


249
b
NCH2CH2OMe
4-F—Ph
501


250
b
NCH2CH2-morphohin-1-yl
4-F—Ph
556


251
b
NCH2CH2CH2OH
4-F—Ph
501


252
b
NCO2Me
3,5-diAc—Ph
567


253
b
COCH2NMe2
3,5-diAc—Ph
594


254
b
NSO2Me
3,5-diAc—Ph
587


255
b
N-4-THTP-dioxide
3,5-diAc—Ph
641


256
b
NCH2-thiazol-2-yl
3,5-diAc—Ph
606


257
b
NCH2CH2OH
3,5-diAc—Ph
553


258
b
NCH2CH2OMe
3,5-diAc—Ph
557


259
b
NCH2CH2-morpholin-1-yl
3,5-diAc—Ph
622


260
b
NCH2CH2CH2OH
3,5-diAc—Ph
567


261
b
NCO2Me
3-Me-5-(1-Me-5-tetrazole)-Ph
579


262
b
COCH2NNe2
3-Ne-5-(1-Me-5-tetrazole)-Ph
606


263
b
NSO2Me
3-Me-5-(1-Me-5-tetrazole)-Ph
599


264
b
NCH2-thiazol-2-yl
3-Me-5-(1-Me-5-tetrazole)-Ph
618


265
b
NCH2CH2OH
3-Me-5-(1-Me-5-tetrazole)-Ph
565


266
b
NCH2CH2OMe
3-Me-5-(1-Me-5-tetrazole)-Ph
579


267
b
NCH2CH2-morpholin-1-yl
3-Me-5-(1-Me-5-tetrazole)-Ph
634


268
b
NCH2CH2CH2OH
3-Me-5-(1-Me-5-tetrazole)-Ph
579


269
b
NCO2Me
3-Br-5-(1-Me-5-tetrazole)-Ph
643


270
b
COCH2NMe2
3-Br-5-(1-Me-5-tetrazole)-Ph
670


271
b
NSO2Me
3-Br-5-(1-Me-5-tetrazole)-Ph
663


272
b
N-4-THTP-dioxide
3-Br-5-(1-Me-5-tetrazole)-Ph
717


273
b
NCH2-thiazoi-2-yl
3-Br-5-(1-Me-5-tetrazole)-Ph
682


274
b
NCH2CH2OH
3-Br-5-(1-Me-5-tetrazole)-Ph
629


275
b
NCH2CH2OMe
3-Br-5-(1-Me-5-tetrazole)-Ph
643


276
b
NCH2CH2CH2OH
3-Br-5-(1-Me-5-tetrazole)-Ph
643


277
d
NBoc
benzyl
539


278
d
NH
benzyl
439


279
d
NEoc
THP-4-ylmethyl
547


280
d
NH
THP-4-ylmethyl
447


281
d
NBoc
THP-4-ylethyl
561


282
d
NH
THP-4-ylethyl
461


283
d
O
3-Me-5-(1-Me-5-tetrazole)-Ph
522


284
d
O
3-(1-Me-5-tetrazole)-Ph
508


285
d
O
5-Ac-4-Me-2-thiazole
489


286
d
O
3-Ac—Ph
468


287
d
O
CH2CH2-morpholin-1yl
463


288
h
SO2
5-Ac-4-Me-2-thiazole
523


289
h
SO2
3-(1-Me-5-tetrazole)-Ph
542


290
h
SO2
3-Ac—Ph
502


291
h
SO2
CH2CH2-morpholin-1yl
497


292
i
SO2
5-Ac-4-Me-2-thiazole
537


293
i
SO2
CH2CH2-morpholin-1yl
511


294
h
NBoc
3-Me-5-(1-Me-5-tetrazole)-Ph
607


295
h
NBoc
5-Ac-4-Me-2-thiazole
474









The following tables contain representative examples of the present invention, and may be prepared by procedures described above, or methods familiar to one skilled in the art. Each entry in each table is intended to be paired with each formulae at the start of the table. For example, Entry 1 in Table 2 is intended to be paired with each of formulae 1-12. (All stereocenters are (+/−) unless otherwise indicated)







TABLE 2































































































































Entry
R16
R9
R3





 1
2-F
H
Ph


2
2-F
H
3-CN—Ph


3
2-F
H
3-COMe—Ph


4
2-F
H
3-CO2Me—Ph


5
2-F
H
3-CONH2—Ph


6
2-F
H
3-CONHMe—Ph


7
2-F
H
3-F—Ph


8
2-F
H
3-Cl—Ph


9
2-F
H
3-Br—Ph


10
2-F
H
3-SO2NH2—Ph


11
2-F
H
3-SO2NHMe—Ph


12
2-F
H
3-CF3—Ph


13
2-F
H
3-OMe—Ph


14
2-F
H
3-SMe—Ph


15
2-F
H
3-SOMe—Ph


16
2-F
H
3-SO2Me—Ph


17
2-F
H
3-OH—Ph


18
2-F
H
3-CH2OH—Ph


19
2-F
H
3-CHOHMe—Ph


20
2-F
H
3-COH(Me)2—Ph


21
2-F
H
3-Me—Ph


22
2-F
H
3-Et—Ph


23
2-F
H
3-iPr—Ph


24
2-F
H
3-tBu—Ph


25
2-F
H
3-CH2CO2Me—Ph


26
2-F
H
3-(1-piperidinyl)-Ph


27
2-F
H
3-(1-pyrrolidinyl)-Ph


28
2-F
H
3-(2-imidazolyl)-Ph


29
2-F
H
3-(1-imidazolyl)-Ph


30
2-F
H
3-(2-thiazolyl)-Ph


31
2-F
H
3-(3-pyrazolyl)-Ph


32
2-F
H
3-(1-pyrazolyl)-Ph


33
2-F
H
3-(5-Me-1-tetrazolyl)-Ph


34
2-F
H
3-(1-Me-5-tetrazolyl)-Ph


35
2-F
H
3-(2-pyridyl)-Ph


36
2-F
H
3- (2-thienyl)-Ph


37
2-F
H
3-(2-furanyl)-Ph


38
2-F
H
4-CN—Ph


39
2-F
H
4-COMe—Ph


40
2-F
H
4-CO2Me—Ph


41
2-F
H
4-CONH2—Ph


42
2-F
H
4-CONHNe—Ph


43
2-F
H
4-CONHPh—Ph


44
2-F
H
4-F—Ph


45
2-F
H
4-Cl—Ph


46
2-F
H
4-Br—Ph


47
2-F
H
4-SO2NH2—Ph


48
2-F
H
4-SO2NHMe—Ph


49
2-F
H
4-CF3—Ph


50
2-F
H
4-OMe—Ph


51
2-F
H
4-SMe—Ph


52
2-F
H
4-SOMe—Ph


53
2-F
H
4-SO2Me—Ph


54
2-F
H
4-OH—Ph


55
2-F
H
4-CH2OH—Ph


56
2-F
H
4-CHOHMe—Ph


57
2-F
H
4-COH(Me)2—Ph


58
2-F
H
4-Me—Ph


59
2-F
H
4-Et—Ph


60
2-F
H
4-iPr—Ph


61
2-F
H
4-tBu—Ph


62
2-F
H
4-CH2CO2Me—Ph


63
2-F
H
4-(1-piperidinyl)-Ph


64
2-F
H
4-(1-pyrrolidinyl)-Ph


65
2-F
H
4-(2-imidazolyl)-Ph


66
2-F
H
4-(1-imidazolyl)-Ph


67
2-F
H
4-(2-thiazolyl)-Ph


68
2-F
H
4-(3-pyrazolyl)-Ph


69
2-F
H
4-(1-pyrazolyl)-Ph


70
2-F
H
4-(5-Me-1-tetrazolyl)-Ph


71
2-F
H
4-(1-Me-5-tetrazolyl)-Ph


72
2-F
H
4-(2-pyridyl)-Ph


73
2-F
H
4-(2-thienyl)-Ph


74
2-F
H
4-(2-furanyl)-Ph


75
2-F
H
2-CN—Ph


76
2-F
H
2-COMe—Ph


77
2-F
H
2-CO2Me—Ph


78
2-F
H
2-CONH2—Ph


79
2-F
H
2-CONHMe—Ph


80
2-F
H
2-F—Ph


81
2-F
H
2-Cl—Ph


82
2-F
H
2-Br—Ph


83
2-F
H
2-SO2NH2—Ph


84
2-F
H
2-SO2NHMe—Ph


85
2-F
H
2-CF3—Ph


86
2-F
H
2-OMe—Ph


87
2-F
H
2-SMe—Ph


88
2-F
H
2-SOMe—Ph


89
2-F
H
2-SO2Me—Ph


90
2-F
H
2-OH—Ph


91
2-F
H
2-CH2OH—Ph


92
2-F
H
2-CHOHMe—Ph


93
2-F
H
2-COH(Me)2—Ph


94
2-F
H
2-Me—Ph


95
2-F
H
2-Et—Ph


96
2-F
H
2-iPr—Ph


97
2-F
H
2-tBu—Ph


98
2-F
H
2-CH2CO2Me—Ph


99
2-F
H
2-(1-piperidinyl)-Ph


100
2-F
H
2-(1-pyrrolidinyl)-Ph


101
2-F
H
2-(2-imidazolyl)-Ph


102
2-F
H
2-(1-imidazolyl)-Ph


103
2-F
H
2-(2-thiazolyl)-Ph


104
2-F
H
2-(3-pyrazolyl)-Ph


105
2-F
H
2-(1-pyrazolyl)-Ph


106
2-F
H
2-(5-Me-1-tetrazolyl)-Ph


107
2-F
H
2-(1-Me-5-tetrazolyl)-Ph


108
2-F
H
2-(2-pyridyl)-Ph


109
2-F
H
2-(2-thienyl)-Ph


110
2-F
H
2-(2-furanyl)-Ph


111
2-F
H
2,4-diF—Ph


112
2-F
H
2,5-diF—Ph


113
2-F
H
2,6-diF—Ph


114
2-F
H
3,4-diF—Ph


115
2-F
H
3,5-diF—Ph


116
2-F
H
2,4-diCl—Ph


117
2-F
H
2,5-diCl—Ph


118
2-F
H
2,6-diCl—Ph


119
2-F
H
3,4-diCl—Ph


120
2-F
H
3,5-diCl—Ph


121
2-F
H
3,4-diCF3—Ph


122
2-F
H
3,5-diCF3—Ph


123
2-F
H
5-Cl-2-MeO—Ph


124
2-F
H
5-Cl-2-Me—Ph


125
2-F
H
2-F-5-Me—Ph


126
2-F
H
3-F-5-morpholino-Ph


127
2-F
H
3,4-OCH2O—Ph


128
2-F
H
3,4-OCH2CH2O—Ph


129
2-F
H
2-MeO-5-CONH2—Ph


130
2-F
H
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


131
2-F
H
2-MeO-5-(1-Me-5-tetrazolyl)-Ph


132
2-F
H
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


133
2-F
H
1-naphthyl


134
2-F
H
2-naphthyl


135
2-F
H
2-thienyl


136
2-F
H
3-thienyl


137
2-F
H
2-furanyl


138
2-F
H
3-furanyl


139
2-F
H
2-pyridyl


140
2-F
H
3-pyridyl


141
2-F
H
4-pyridyl


142
2-F
H
2-indolyl


143
2-F
H
3-indolyl


144
2-F
H
5-indolyl


145
2-F
H
6-indolyl


146
2-F
H
3-indazolyl


147
2-F
H
5-indazolyl


148
2-F
H
6-indazolyl


149
2-F
H
2-imidazolyl


150
2-F
H
3-isoxazoyl


151
2-F
H
3-pyrazolyl


152
2-F
H
2-thiadiazolyl


153
2-F
H
2-thiazolyl


154
2-F
H
5-Ac-4-Me-2-thiazolyl


155
2-F
H
5-tetrazolyl


156
2-F
H
2-benzimidazolyl


157
2-F
H
5-benzimidazolyl


158
2-F
H
2-benzothiazolyl


159
2-F
H
5-benzothiazolyl


160
2-F
H
2 -benzoxazolyl


161
2-F
H
5-benzoxazolyl


162
2-F
H
1-adamantyl


163
2-F
H
2-adamantyl


164
2-F
H
i-Pr


165
2-F
H
t-Bu


166
2-F
H
c-Hex


167
2-F
H
CH2CH2OMe


168
2-F
H
CH2CONH2


169
2-F
H
CH2CO2Me


170
2-F
H
CH(CH2Ph)CO2Me


171
2-F
H
CH2CH2NMe2


172
2-F
H
benzyl


173
2-F
H
phenethyl


174
2-F
H
2-(morpholin-1-yl)-Et


175
2-F
Me
Ph


176
2-F
Me
3-CN—Ph


177
2-F
Me
3-COMe—Ph


178
2-F
Me
3-CO2Me—Ph


179
2-F
Me
3-CONH2—Ph


180
2-F
Me
3-CONHMe—Ph


181
2-F
Me
3-F—Ph


182
2-F
Me
3-Cl—Ph


183
2-F
Me
3-Br—Ph


184
2-F
Me
3-SO2NH2—Ph


185
2-F
Me
3-SO2NHMe—Ph


186
2-F
Me
3-CF3—Ph


187
2-F
Me
3-OMe—Ph


188
2-F
Me
3-SMe—Ph


189
2-F
Me
3-SOMe—Ph


190
2-F
Me
3-SO2Me—Ph


191
2-F
Me
3-OH—Ph


192
2-F
Me
3-CH2OH—Ph


193
2-F
Me
3-CHOHMe—Ph


194
2-F
Me
3-COH(Me)2—Ph


195
2-F
Me
3-Me—Ph


196
2-F
Me
3-Et—Ph


197
2-F
Me
3-iPr—Ph


198
2-F
Me
3-tBu—Ph


199
2-F
Me
3-CH2CO2Me—Ph


200
2-F
Me
3-(1-piperidinyl)-Ph


201
2-F
Me
3-(1-pyrrolidinyl)-Ph


202
2-F
Me
3-(2-imidazolyl)-Ph


203
2-F
Me
3-(1-imidazolyl)-Ph


204
2-F
Me
3-(2-thiazolyl)-Ph


205
2-F
Me
3-(3-pyrazolyl)-Ph


206
2-F
Me
3-(1-pyrazolyl)-Ph


207
2-F
Me
3-(5-Me-1-tetrazolyl)-Ph


208
2-F
Me
3-(1-Me-5-tetrazolyl)-Ph


209
2-F
Me
3-(2-pyridyl)-Ph


210
2-F
Me
3-(2-thienyl)-Ph


211
2-F
Me
3-(2-furanyl)-Ph


212
2-F
Me
4-CN—Ph


213
2-F
Me
4-COMe—Ph


214
2-F
Me
4-CO2Me—Ph


215
2-F
Me
4-CONH2—Ph


216
2-F
Me
4-CONHMe—Ph


217
2-F
Me
4-CONHPh—Ph


218
2-F
Me
4-F—Ph


219
2-F
Me
4-Cl—Ph


220
2-F
Me
4-Br—Ph


221
2-F
Me
4-SO2NH2—Ph


222
2-F
Me
4-SO2NHMe—Ph


223
2-F
Me
4-CF3—Ph


224
2-F
Me
4-OMe—Ph


225
2-F
Me
4-SMe—Ph


226
2-F
Me
4-SOMe—Ph


227
2-F
Me
4-SO2Me—Ph


228
2-F
Me
4-OH—Ph


229
2-F
Me
4-CH2OH—Ph


230
2-F
Me
4-CHOHMe—Ph


231
2-F
Me
4-COH(Me)2—Ph


232
2-F
Me
4-Me—Ph


233
2-F
Me
4-Et—Ph


234
2-F
Me
4-iPr—Ph


235
2-F
Me
4-tBu—Ph


236
2-F
Me
4-CH2CO2Me—Ph


237
2-F
Me
4-(1-piperidinyl)-Ph


238
2-F
Me
4-(1-pyrrolidinyl)-Ph


239
2-F
Me
4-(2-imidazolyl)-Ph


240
2-F
Me
4-(1-imidazolyl)-Ph


241
2-F
Me
4-(2-thiazolyl)-Ph


242
2-F
Me
4-(3-pyrazolyl)-Ph


243
2-F
Me
4-(1-pyrazolyl)-Ph


244
2-F
Me
4-(5-Me-1-tetrazolyl)-Ph


245
2-F
Me
4-(1-Me-5-tetrazolyl)-Ph


246
2-F
Me
4-(2-pyridyl)-Ph


247
2-F
Me
4-(2-thienyl)-Ph


248
2-F
Me
4-(2-furanyl)-Ph


249
2-F
Me
2-CN—Ph


250
2-F
Me
2-COMe—Ph


251
2-F
Me
2-CO2Me—Ph


252
2-F
Me
2-CONH2—Ph


253
2-F
Me
2-CONHMe—Ph


254
2-F
Me
2-F—Ph


255
2-F
Me
2-Cl—Ph


256
2-F
Me
2-Br—Ph


257
2-F
Me
2-SO2NH2—Ph


258
2-F
Me
2-SO2NHMe—Ph


259
2-F
Me
2-CF3—Ph


260
2-F
Me
2-OMe—Ph


261
2-F
Me
2-SMe—Ph


262
2-F
Me
2-SOMe—Ph


263
2-F
Me
2-SO2Me—Ph


264
2-F
Me
2-OH—Ph


265
2-F
Me
2-CH2OH—Ph


266
2-F
Me
2-CHOHMe—Ph


267
2-F
Me
2-COH(Me)2—Ph


268
2-F
Me
2-Me—Ph


269
2-F
Me
2-Et—Ph


270
2-F
Me
2-iPr—Ph


271
2-F
Me
2-tBu—Ph


272
2-F
Me
2-CH2CO2Me—Ph


273
2-F
Me
2-(1-piperidinyl)-Ph


274
2-F
Me
2-(1-pyrrolidinyl)-Ph


275
2-F
Me
2-(2-imidazollyl)-Ph


276
2-F
Me
2-(1-imidazolyl)-Ph


277
2-F
Me
2-(2-thiazolyl)-Ph


278
2-F
Me
2-(3-pyrazolyl)-Ph


279
2-F
Me
2-(1-pyrazolyl)-Ph


280
2-F
Me
2-(5-Me-1-tetrazolyl)-Ph


281
2-F
Me
2-(1-Me-5-tetrazoyl)-Ph


282
2-F
Me
2-(2-pyridyl)-Ph


283
2-F
Me
2-(2-thienyl)-Ph


284
2-F
Me
2-(2-furanyl)-Ph


285
2-F
Me
2,4-diF—Ph


286
2-F
Me
2,5-diF—Ph


287
2-F
Me
2,6-diF—Ph


288
2-F
Me
3,4-diF—Ph


289
2-F
Me
3,5-diF—Ph


290
2-F
Me
2,4-diCl—Ph


291
2-F
Me
2,5-diCl—Ph


292
2-F
Me
2,6-diCl—Ph


293
2-F
Me
3,4-diCl—Ph


294
2-F
Me
3,5-diCl—Ph


295
2-F
Me
3,4-diCF3—Ph


296
2-F
Me
3,5-diCF3—Ph


297
2-F
Me
5-Cl-2-MeO—Ph


298
2-F
Me
5-Cl-2-Me—Ph


299
2-F
Me
2-F-5-Me—Ph


300
2-F
Me
3-F-5-morpholino-Ph


301
2-F
Me
3,4-OCH2O—Ph


302
2-F
Me
3,4-OCH2CH2O—Ph


303
2-F
Me
2-MeO-5-CONH2—Ph


304
2-F
Me
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


305
2-F
Me
2-MeO-5-(1-Me-5-tetrazolyl)-Ph


306
2-F
Me
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


307
2-F
Me
1-naphthyl


308
2-F
Me
2-naphthyl


309
2-F
Me
2-thienyl


310
2-F
Me
3-thienyl


311
2-F
Me
2-furanyl


312
2-F
Me
3-furanyl


313
2-F
Me
2-pyridyl


314
2-F
Me
3-pyridyl


315
2-F
Me
4-pyridyl


316
2-F
Me
2-indolyl


317
2-F
Me
3-indolyl


318
2-F
Me
5-indolyl


319
2-F
Me
6-indolyl


320
2-F
Me
3-indazolyl


321
2-F
Me
5-indazolyl


322
2-F
Me
6-indazolyl


323
2-F
Me
2-imidazolyl


324
2-F
Me
3-isoxazoyl


325
2-F
Me
3-pyrazolyl


326
2-F
Me
2-thiadiazolyl


327
2-F
Me
2-thiazolyl


328
2-F
Me
5-Ac-4-Me-2-thiazolyl


329
2-F
Me
5-tetrazolyl


330
2-F
Me
2-benzimidazolyl


331
2-F
Me
5-benzimidazolyl


332
2-F
Me
2-benzothiazolyl


333
2-F
Me
5-benzothiazolyl


334
2-F
Me
2-benzoxazolyl


335
2-F
Me
5-benzoxazolyl


336
2-F
Me
1-adamantyl


337
2-F
Me
2-adamantyl


338
2-F
Me
i-Pr


339
2-F
Me
t-Bu


340
2-F
Me
c-Hex


341
2-F
Me
CH2CH2OMe


342
2-F
Me
CH2CONH2


343
2-F
Me
CH2CO2Me


344
2-F
Me
CH(CH2Ph)CO2Me


345
2-F
Me
CH2CH2NMe2


346
2-F
Me
benzyl


347
2-F
Me
phenethyl


348
2-F
Me
2-(morpholin-1-yl)-Et


349
2-F
2-F—Et
Ph


350
2-F
2-F—Et
3-CN—Ph


351
2-F
2-F—Et
3-COMe—Ph


352
2-F
2-F—Et
3-CO2Me—Ph


353
2-F
2-F—Et
3-CONH2—Ph


354
2-F
2-F—Et
3-CONHMe—Ph


355
2-F
2-F—Et
3-F—Ph


356
2-F
2-F—Et
3-Cl—Ph


357
2-F
2-F—Et
3-Br—Ph


358
2-F
2-F—Et
3-SO2NH2—Ph


359
2-F
2-F—Et
3-SO2NHMe—Ph


360
2-F
2-F—Et
3-CF3—Ph


361
2-F
2-F—Et
3-OMe—Ph


362
2-F
2-F—Et
3-SMe—Ph


363
2-F
2-F—Et
3-SOMe—Ph


364
2-F
2-F—Et
3-SO2Me—Ph


365
2-F
2-F—Et
3-OH—Ph


366
2-F
2-F—Et
3-CH2OH—Ph


367
2-F
2-F—Et
3-CHOHMe—Ph


368
2-F
2-F—Et
3-COH(Me)2—Ph


369
2-F
2-F—Et
3-Me—Ph


370
2-F
2-F—Et
3-Et—Ph


371
2-F
2-F—Et
3-iPr—Ph


372
2-F
2-F—Et
3-tBu—Ph


373
2-F
2-F—Et
3-CH2CO2Me—Ph


374
2-F
2-F—Et
3-(1-piperidinyl)-Ph


375
2-F
2-F—Et
3-(1-pyrrolidinyl)-Ph


376
2-F
2-F—Et
3-(2-imidazolyl)-Ph


377
2-F
2-F—Et
3-(1-imidazolyl)-Ph


378
2-F
2-F—Et
3-(2-thiazolyl)-Ph


379
2-F
2-F—Et
3-(3-pyrazolyl)-Ph


380
2-F
2-F—Et
3-(1-pyrazolyl)-Ph


381
2-F
2-F—Et
3-(5-Me-1-tetrazolyl)-Ph


382
2-F
2-F—Et
3-(1-Me-5-tetrazolyl)-Ph


383
2-F
2-F—Et
3-(2-pyridyl)-Ph


384
2-F
2-F—Et
3-(2-thienyl)-Ph


385
2-F
2-F—Et
3-(2-furanyl)-Ph


386
2-F
2-F—Et
4-CN—Ph


387
2-F
2-F—Et
4-COMe—Ph


388
2-F
2-F—Et
4-CO2Me—Ph


389
2-F
2-F—Et
4-CONH2—Ph


390
2-F
2-F—Et
4-CONHMe—Ph


391
2-F
2-F—Et
4-CONHPh—Ph


392
2-F
2-F—Et
4-F—Ph


393
2-F
2-F—Et
4-Cl—Ph


394
2-F
2-F—Et
4-Br—Ph


395
2-F
2-F—Et
4-SO2NH2—Ph


396
2-F
2-F—Et
4-SO2NHMe—Ph


397
2-F
2-F—Et
4-CF3—Ph


398
2-F
2-F—Et
4-OMe—Ph


399
2-F
2-F—Et
4-SMe—Ph


400
2-F
2-F—Et
4-SOMe—Ph


401
2-F
2-F—Et
4-SO2Me—Ph


402
2-F
2-F—Et
4-OH—Ph


403
2-F
2-F—Et
4-CH2OH—Ph


404
2-F
2-F—Et
4-CHOHMe—Ph


405
2-F
2-F—Et
4-COH(Me)2—Ph


406
2-F
2-F—Et
4-Me—Ph


407
2-F
2-F—Et
4-Et—Ph


408
2-F
2-F—Et
4-iPr—Ph


409
2-F
2-F—Et
4-tBu—Ph


410
2-F
2-F—Et
4-CH2CO2Me—Ph


411
2-F
2-F—Et
4-(1-piperidinyl)-Ph


412
2-F
2-F—Et
4-(1-pyrrolidinyl)-Ph


413
2-F
2-F—Et
4-(2-imidazolyl)-Ph


414
2-F
2-F—Et
4-(1-imidazolyl)-Ph


415
2-F
2-F—Et
4-(2-thiazolyl)-Ph


416
2-F
2-F—Et
4-(3-pyrazolyl)-Ph


417
2-F
2-F—Et
4-(1-pyrazolyl)-Ph


418
2-F
2-F—Et
4-(5-Me-1-tetrazolyl)-Ph


419
2-F
2-F—Et
4-(1-Me-5-tetrazolyl)-Ph


420
2-F
2-F—Et
4-(2-pyridyl)-Ph


421
2-F
2-F—Et
4-(2-thienyl)-Ph


422
2-F
2-F—Et
4-(2-furanyl)-Ph


423
2-F
2-F—Et
2-CN—Ph


424
2-F
2-F—Et
2-COMe—Ph


425
2-F
2-F—Et
2-CO2Me—Ph


426
2-F
2-F—Et
2-CONH2—Ph


427
2-F
2-F—Et
2-CONHMe—Ph


428
2-F
2-F—Et
2-F—Ph


429
2-F
2-F—Et
2-Cl—Ph


430
2-F
2-F—Et
2-Br—Ph


431
2-F
2-F—Et
2-SO2NH2—Ph


432
2-F
2-F—Et
2-SO2NHMe—Ph


433
2-F
2-F—Et
2-CF3—Ph


434
2-F
2-F—Et
2-OMe—Ph


435
2-F
2-F—Et
2-SMe—Ph


436
2-F
2-F—Et
2-SOMe—Ph


437
2-F
2-F—Et
2-SO2Me—Ph


438
2-F
2-F—Et
2-OH—Ph


439
2-F
2-F—Et
2-CH2OH—Ph


440
2-F
2-F—Et
2-CHOHMe—Ph


441
2-F
2-F—Et
2-COH(Me)2—Ph


442
2-F
2-F—Et
2-Me—Ph


443
2-F
2-F—Et
2-EL—Ph


444
2-F
2-F—Et
2-iPr—Ph


445
2-F
2-F—Et
2-tBu—Ph


446
2-F
2-F—Et
2-CH2CO2Me—Ph


447
2-F
2-F—Et
2-(1-piperidinyl)-Ph


448
2-F
2-F—Et
2-(1-pyrrolidinyl)-Ph


449
2-F
2-F—Et
2-(2-imidazolyl)-Ph


450
2-F
2-F—Et
2-(1-imidazolyl)-Ph


451
2-F
2-F—Et
2-(2-thiazolyl)-Ph


452
2-F
2-F—Et
2-(3-pyrazolyl)-Ph


453
2-F
2-F—Et
2-(1-pyrazolyl)-Ph


454
2-F
2-F—Et
2-(5-Me-1-tetrazolyl)-Ph


455
2-F
2-F—Et
2-(1-Me-5-tetrazolyl)-Ph


456
2-F
2-F—Et
2-(2-pyridyl)-Ph


457
2-F
2-F—Et
2-(2-thienyl)-Ph


458
2-F
2-F—Et
2-(2-furanyl)-Ph


459
2-F
2-F—Et
2,4-diF—Ph


460
2-F
2-F—Et
2,5-diF—Ph


461
2-F
2-F—Et
2,6-diF—Ph


462
2-F
2-F—Et
3,4-diF—Ph


463
2-F
2-F—Et
3,5-diF—Ph


464
2-F
2-F—Et
2. 4-diCl—Ph


465
2-F
2-F—Et
2,5-diCl—Ph


466
2-F
2-F—Et
2,6-diCl—Ph


467
2-F
2-F—Et
3,4-diCl—Ph


468
2-F
2-F—Et
3,5-diCl—Ph


469
2-F
2-F—Et
3,4-diCF3—Ph


470
2-F
2-F—Et
3,5-diCF3—Ph


471
2-F
2-F—Et
5-Cl-2-MeO—Ph


472
2-F
2-F—Et
5-Cl-2-Me—Ph


473
2-F
2-F—Et
2-F-5-Me—Ph


474
2-F
2-F—Et
3-F-5-morpholino-Ph


475
2-F
2-F—Et
3,4-OCH2O—Ph


476
2-F
2-F—Et
3,4-OCH2CH2O—Ph


477
2-F
2-F—Et
2-MeO-5-CONH2—Ph


478
2-F
2-F—Et
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


479
2-F
2-F—Et
2-MeO-5-(1-Me-5-tetrazolyl)-Ph


480
2-F
2-F—Et
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


481
2-F
2-F—Et
1-napthyl


482
2-F
2-F—Et
2-napthyl


483
2-F
2-F—Et
2-thienyl


484
2-F
2-F—Et
3-thienyl


485
2-F
2-F—Et
2-furanyl


486
2-F
2-F—Et
3-furanyl


487
2-F
2-F—Et
2-pyridyl


488
2-F
2-F—Et
3-pyridyl


489
2-F
2-F—Et
4-pyridyl


490
2-F
2-F—Et
2-indolyl


491
2-F
2-F—Et
3-indolyl


492
2-F
2-F—Et
5-indolyl


493
2-F
2-F—Et
6-indolyl


494
2-F
2-F—Et
3-indazolyl


495
2-F
2-F—Et
5-indazolyl


496
2-F
2-F—Et
6-indazolyl


497
2-F
2-F—Et
2-imidazolyl


498
2-F
2-F—Et
3-isoxazoyl


499
2-F
2-F—Et
3-pyrazolyl


500
2-F
2-F—Et
2-thiadiazolyl


501
2-F
2-F—Et
2-thiazolyl


502
2-F
2-F—Et
5-Ac-4-Me-2-thiazolyl


503
2-F
2-F—Et
5-tetrazolyl


504
2-F
2-F—Et
2-benzimidazolyl


505
2-F
2-F—Et
5-benzimidazolyl


506
2-F
2-F—Et
2-benzothiazolyl


507
2-F
2-F—Et
5-benzothiazolyl


508
2-F
2-F—Et
2-benzoxazolyl


509
2-F
2-F—Et
5-benzoxazolyl


510
2-F
2-F—Et
1-adamantyl


511
2-F
2-F—Et
2-adamantyl


512
2-F
2-F—Et
i-Pr


513
2-F
2-F—Et
t-Bu


514
2-F
2-F—Et
c-Hex


515
2-F
2-F—Et
CH2CH2OMe


516
2-F
2-F—Et
CH2CONH2


517
2-F
2-F—Et
CH2CO2Me


518
2-F
2-F—Et
CH(CH2Ph)CO2Me


519
2-F
2-F—Et
CH2CH2NMe2


520
2-F
2-F—Et
benzyl


521
2-F
2-F—Et
phenethyl


522
2-F
2-F—Et
2-(morpholin-1-yl)-Et


523
2-F
CO2Me
Ph


524
2-F
CO2Me
3-CN—Ph


525
2-F
CO2Me
3-COMe—Ph


526
2-F
CO2Me
3-CO2Me—Ph


527
2-F
CO2Me
3-CONH2—Ph


528
2-F
CO2Me
3-CONHMe—Ph


529
2-F
CO2Me
3-F—Ph


530
2-F
CO2Me
3-Cl—Ph


531
2-F
CO2Me
3-Br—Ph


532
2-F
CO2Me
3-SO2NH2—Ph


533
2-F
CO2Me
3-SO2NhMe—Ph


534
2-F
CO2Me
3-CF3—Ph


535
2-F
CO2Me
3-OMe—Ph


536
2-F
CO2Me
3-SMe—Ph


537
2-F
CO2Me
3-SOMe—Ph


538
2-F
CO2Me
3-SO2Me—Ph


539
2-F
CO2Me
3-OH—Ph


540
2-F
CO2Me
3-CH2OH—Ph


541
2-F
CO2Me
3-CHOHMe—Ph


542
2-F
CO2Me
3-COH(Me)2—Ph


543
2-F
CO2Me
3-Me—Ph


544
2-F
CO2Me
3-Et—Ph


545
2-F
CO2Me
3-iPr—Ph


546
2-F
CO2Me
3-tBu—Ph


547
2-F
CO2Me
3-CH2CO2Me—Ph


548
2-F
CO2Me
3-(1-piperidinyl)-Ph


549
2-F
CO2Me
3-(1-pyrrolidinyl)-Ph


550
2-F
CO2Me
3-(2-imidazolyl)-Ph


551
2-F
CO2Me
3-(1-imidazolyl)-Ph


552
2-F
CO2Me
3-(2-thiazolyl)-Ph


553
2-F
CO2Me
3-(3-pyrazolyl)-Ph


554
2-F
CO2Me
3-(1-pyrazolyl)-Ph


555
2-F
CO2Me
3-(5-Me-1-tetrazolyl)-Ph


556
2-F
CO2Me
3-(1-Me-5-tetrazolyl)-Ph


557
2-F
CO2Me
3-(2-pyridyl)-Ph


558
2-F
CO2Me
3-(2-thienyl)-Ph


559
2-F
CO2Me
3-(2-furanyl)-Ph


560
2-F
CO2Me
4-CN—Ph


561
2-F
CO2Me
4-COMe—Ph


562
2-F
CO2Me
4-CO2Me—Ph


563
2-F
CO2Me
4-CONH2—Ph


564
2-F
CO2Me
4-CONHMe—Ph


565
2-F
CO2Me
4-CONHPh—Ph


566
2-F
CO2Me
4-F—Ph


567
2-F
CO2Me
4-Cl—Ph


568
2-F
CO2Me
4-Br—Ph


569
2-F
CO2Me
4-SO2NH2—Ph


570
2-F
CO2Me
4-SO2NHMe—Ph


571
2-F
CO2Me
4-CF3—Ph


572
2-F
CO2Me
4-OMe—Ph


573
2-F
CO2Me
4-SMe—Ph


574
2-F
CO2Me
4-SOMe—Ph


575
2-F
CO2Me
4-SO2Me—Ph


576
2-F
CO2Me
4-OH—Ph


577
2-F
CO2Me
4-CH2OH—Ph


578
2-F
CO2Me
4-CHOHMe—Ph


579
2-F
CO2Me
4-COH(Me)2—Ph


580
2-F
CO2Me
4-Me—Ph


581
2-F
CO2Me
4-Et—Ph


582
2-F
CO2Me
4-iPr—Ph


583
2-F
CO2Me
4-tBu—Ph


584
2-F
CO2Me
4-CH2CO2Me—Ph


585
2-F
CO2Me
4-(1-piperidinyl)-Ph


586
2-F
CO2Me
4-(1-pyrrolidinyl)-Ph


587
2-F
CO2Me
4-(2-imidazolyl)-Ph


588
2-F
CO2Me
4-(1-imidazolyl)-Ph


589
2-F
CO2Me
4-(2-thiazolyl)-Ph


590
2-F
CO2Me
4-(3-pyrazolyl)-Ph


591
2-F
CO2Me
4-(1-pyrazolyl)-Ph


592
2-F
CO2Me
4-(5-Me-1-tetrazolyl)-Ph


593
2-F
CO2Me
4-(1-Me-5-tetrazolyl)-Ph


594
2-F
CO2Me
4-(2-pyridyl)-Ph


595
2-F
CO2Me
4-(2-thienyl)-Ph


596
2-F
CO2Me
4-(2-furanyl)-Ph


597
2-F
CO2Me
2-CN—Ph


598
2-F
CO2Me
2-COMe—Ph


599
2-F
CO2Me
2-CO2Me—Ph


600
2-F
CO2Me
2-CONH2—Ph


601
2-F
CO2Me
2-CONHMe—Ph


602
2-F
CO2Me
2-F—Ph


603
2-F
CO2Me
2-Cl—Ph


604
2-F
CO2Me
2-Br—Ph


605
2-F
CO2Me
2-SO2NH2—Ph


606
2-F
CO2Me
2-SO2NHMe—Ph


607
2-F
CO2Me
2-CF3—Ph


608
2-F
CO2Me
2-OMe—Ph


609
2-F
CO2Me
2-SMe—Ph


610
2-F
CO2Me
2-SOMe—Ph


611
2-F
CO2Me
2-SO2Me—Ph


612
2-F
CO2Me
2-OH—Ph


613
2-F
CO2Me
2-CH2OH—Ph


614
2-F
CO2Me
2-CHOHMe—Ph


615
2-F
CO2Me
2-COH(Me)2—Ph


616
2-F
CO2Me
2-Me—Ph


617
2-F
CO2Me
2-Et—Ph


618
2-F
CO2Me
2-iPr—Ph


619
2-F
CO2Me
2-tBu—Ph


620
2-F
CO2Me
2-CH2CO2Me—Ph


621
2-F
CO2Me
2-(1-piperidinyl)-Ph


622
2-F
CO2Me
2-(1-pyrrolidinyl)—Ph


623
2-F
CO2Me
2-(2-imidazolyl)-Ph


624
2-F
CO2Me
2-(1-imidazolyl)-Ph


625
2-F
CO2Me
2-(2-thiazolyl)-Ph


626
2-F
CO2Me
2-(3-pyrazolyl)-Ph


627
2-F
CO2Me
2-(1-pyrazolyl)-Ph


628
2-F
CO2Me
2-(5-Me-1-tetrazolyl)-Ph


629
2-F
CO2Me
2-(1-Me-5-tetrazolyl)-Ph


630
2-F
CO2Me
2-(2-pyridyl)-Ph


631
2-F
CO2Me
2-(2-thienyl)-Ph


632
2-F
CO2Me
2-(2-furanyl)-Ph


633
2-F
CO2Me
2,4-diF—Ph


634
2-F
CO2Me
2,5-diF—Ph


635
2-F
CO2Me
2,6-diF—Ph


636
2-F
CO2Me
3,4-diF—Ph


637
2-F
CO2Me
3,5-diF—Ph


638
2-F
CO2Me
2,4-diCl—Ph


639
2-F
CO2Me
2,5-diCl—Ph


640
2-F
CO2Me
2,6-diCl—Ph


641
2-F
CO2Me
3,4-diCl—Ph


642
2-F
CO2Me
3,5-diCl—Ph


643
2-F
CO2Me
3,4-diCF3—Ph


644
2-F
CO2Me
3,5-diCF3—Ph


645
2-F
CO2Me
5-Cl-2-MeO—Ph


646
2-F
CO2Me
5-Cl-2-Me—Ph


647
2-F
CO2Me
2-F-5-Me—Ph


648
2-F
CO2Me
3-F-5-morpholino-Ph


649
2-F
CO2Me
3,4-OCH2O—Ph


650
2-F
CO2Me
3,4-OCH2CH2O—Ph


651
2-F
CO2Me
2-MeO-5-CONH2—Ph


652
2-F
CO2Me
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


653
2-F
CO2Me
2-MeO-5-(1-Me-5-tetrazolyl)-Ph


654
2-F
CO2Me
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


655
2-F
CO2Me
1-naphthyl


656
2-F
CO2Me
2-naphthyl


657
2-F
CO2Me
2-thienyl


658
2-F
CO2Me
3-thienyl


659
2-F
CO2Me
2-furanyl


660
2-F
CO2Me
3-furanyl


661
2-F
CO2Me
2-pyridyl


662
2-F
CO2Me
3-pyridyl


663
2-F
CO2Me
4-pyridyl


664
2-F
CO2Me
2-indolyl


665
2-F
CO2Me
3-indolyl


666
2-F
CO2Me
5-indolyl


667
2-F
CO2Me
6-indolyl


668
2-F
CO2Me
3-indazolyl


669
2-F
CO2Me
5-indazolyl


670
2-F
CO2Me
6-indazolyl


671
2-F
CO2Me
2-imidazolyl


672
2-F
CO2Me
3-isoxazoyl


673
2-F
CO2Me
3-pyrazolyl


674
2-F
CO2Me
2-thiadiazolyl


675
2-F
CO2Me
2-thiazolyl


676
2-F
CO2Me
5-Ac-4-Me-2-thiazolyl


677
2-F
CO2Me
5-tetrazolyl


678
2-F
CO2Me
2-benzimidazolyl


679
2-F
CO2Me
5-benzirnidazolyl


680
2-F
CO2Me
2-benzothiazolyl


681
2-F
CO2Me
5-benzothiazolyl


682
2-F
CO2Me
2-benzoxazolyl


683
2-F
CO2Me
5-benzoxazolyl


684
2-F
CO2Me
1-adamantyl


685
2-F
CO2Me
2-adamantyl


686
2-F
CO2Me
i-Pr


687
2-F
CO2Me
t-Bu


688
2-F
CO2Me
c-Hex


689
2-F
CO2Me
CH2CH2OMe


690
2-F
CO2Me
CH2CONH2


691
2-F
CO2Me
CH2CO2Me


692
2-F
CO2Me
CH(CH2Ph)CO2Me


693
2-F
CO2Me
CH2CH2NMe2


694
2-F
CO2Me
benzyl


695
2-F
CO2Me
phenethyl


696
2-F
CO2Me
2-(morpholin-1-yl)-Et


697
2-F
Ac
Ph


698
2-F
Ac
3-CN—Ph


699
2-F
Ac
3-COMe—Ph


700
2-F
Ac
3-CO2Me—Ph


701
2-F
Ac
3-CONH2—Ph


702
2-F
Ac
3-CONHMe—Ph


703
2-F
Ac
3-F—Ph


704
2-F
Ac
3-Cl—Ph


705
2-F
Ac
3-Br—Ph


706
2-F
Ac
3-SO2NH2—Ph


707
2-F
Ac
3-SO2NHMe—Ph


708
2-F
Ac
3-CF3—Ph


709
2-F
Ac
3-OMe—Ph


710
2-F
Ac
3-SMe—Ph


711
2-F
Ac
3-SOMe—Ph


712
2-F
Ac
3-SO2Me—Ph


713
2-F
Ac
3-OH—Ph


714
2-F
Ac
3-CH2OH—Ph


715
2-F
Ac
3-CHOHMe—Ph


716
2-F
Ac
3-COH(Me)2—Ph


717
2-F
Ac
3-Me—Ph


718
2-F
Ac
3-Et—Ph


719
2-F
Ac
3-iPr—Ph


720
2-F
Ac
3-tBu—Ph


721
2-F
Ac
3-CH2CO2Me—Ph


722
2-F
Ac
3-(1-piperidinyl)-Ph


723
2-F
Ac
3-(1-pyrrolidinyl)-Ph


724
2-F
Ac
3-(2-imidazolyl)-Ph


725
2-F
Ac
3-(1-imidazolyl)-Ph


726
2-F
Ac
3-(2-thiazolyl)-Ph


727
2-F
Ac
3-(3-pyrazolyl)-Ph


728
2-F
Ac
3-(1-pyrazolyl)-Ph


729
2-F
Ac
3-(5-Me-1-tetrazolyl)-Ph


730
2-F
Ac
3-(1-Me-5-tetrazolyl)-Ph


731
2-F
Ac
3-(2-pyridyl)-Ph


732
2-F
Ac
3-(2-thienyl)-Ph


733
2-F
Ac
3-(2-furanyl)-Ph


734
2-F
Ac
4-CN—Ph


735
2-F
Ac
4-COMe—Ph


736
2-F
Ac
4-CO2Me—Ph


737
2-F
Ac
4-CONH2—Ph


738
2-F
Ac
4-CONHMe—Ph


739
2-F
Ac
4-CONHPh—Ph


740
2-F
Ac
4-F—Ph


741
2-F
Ac
4-Cl—Ph


742
2-F
Ac
4-Br—Ph


743
2-F
Ac
4-SO2NH2—Ph


744
2-F
Ac
4-SO2NHMe—Ph


745
2-F
Ac
4-CF3—Ph


746
2-F
Ac
4-OMe—Ph


747
2-F
Ac
4-SMe—Ph


748
2-F
Ac
4-SOMe—Ph


749
2-F
Ac
4-SO2Me—Ph


750
2-F
Ac
4-OH—Ph


751
2-F
Ac
4-CH2OH—Ph


752
2-F
Ac
4-CHOHMe—Ph


753
2-F
Ac
4-COH(Me)2—Ph


754
2-F
Ac
4-Me—Ph


755
2-F
Ac
4-Et—Ph


756
2-F
Ac
4-iPr—Ph


757
2-F
Ac
4-tBu—Ph


758
2-F
Ac
4-CH2CO2Me—Ph


759
2-F
Ac
4-(1-piperidinyl)-Ph


760
2-F
Ac
4-(1-pyrrolidinyl)-Ph


761
2-F
Ac
4-(2-imidazolyl)-Ph


762
2-F
Ac
4-(1-imidazolyl)-Ph


763
2-F
Ac
4-(2-thiazolyl)-Ph


764
2-F
Ac
4-(3-pyrazolyl)-Ph


765
2-F
Ac
4-(1-pyrazolyl)-Ph


766
2-F
Ac
4-(5-Me-1-tetrazolyl)-Ph


767
2-F
Ac
4-(1-Me-5-tetrazolyl)-Ph


768
2-F
Ac
4-(2-pyridyl)-Ph


769
2-F
Ac
4-(2-thienyl)-Ph


770
2-F
Ac
4-(2-furanyl)-Ph


771
2-F
Ac
2-CN—Ph


772
2-F
Ac
2-COMe—Ph


773
2-F
Ac
2-CO2Me—Ph


774
2-F
Ac
2-CONH2—Ph


775
2-F
Ac
2-CONHMe—Ph


776
2-F
Ac
2-F—Ph


777
2-F
Ac
2-Cl—Ph


778
2-F
Ac
2-Br—Ph


779
2-F
Ac
2-SO2NH2—Ph


780
2-F
Ac
2-SO2NHMe—Ph


781
2-F
Ac
2-CF3—Ph


782
2-F
Ac
2-OMe—Ph


783
2-F
Ac
2-SMe—Ph


784
2-F
Ac
2-SOMe—Ph


785
2-F
Ac
2-SO2Me—Ph


786
2-F
Ac
2-OH—Ph


787
2-F
Ac
2-CH2OH—Ph


788
2-F
Ac
2-CHOHMe—Ph


789
2-F
Ac
2-COH(Me)2—Ph


790
2-F
Ac
2-Me—Ph


791
2-F
Ac
2-Et—Ph


792
2-F
Ac
2-iPr—Ph


793
2-F
Ac
2-tBu—Ph


794
2-F
Ac
2-CH2CO2Me—Ph


795
2-F
Ac
2-(1-piperidinyl)-Ph


796
2-F
Ac
2-(1-pyrrolidinyl)-Ph


797
2-F
Ac
2-(2-imidazolyl)-Ph


798
2-F
Ac
2-(1-imidazolyl)-Ph


799
2-F
Ac
2-(2-thiazolyl)-Ph


800
2-F
Ac
2-(3-pyrazolyl)-Ph


801
2-F
Ac
2-(1-pyrazolyl)-Ph


802
2-F
Ac
2-(5-Me-1-tetrazolyl)-Ph


803
2-F
Ac
2-(1-Me-5-tetrazolyl)-Ph


804
2-F
Ac
2-(2-pyridyl)-Ph


805
2-F
Ac
2-(2-thienyl)-Ph


806
2-F
Ac
2-(2-furanyl)-Ph


807
2-F
Ac
2,4-diF—Ph


808
2-F
Ac
2,5-diF—Ph


809
2-F
Ac
2,6-diF—Ph


810
2-F
Ac
3,4-diF—Ph


811
2-F
Ac
3,5-diF—Ph


812
2-F
Ac
2,4-diCl—Ph


813
2-F
Ac
2,5-diCl—Ph


814
2-F
Ac
2,6-diCl—Ph


815
2-F
Ac
3,4-diCl—Ph


816
2-F
Ac
3,5-diCl—Ph


817
2-F
Ac
3,4-diCF3—Ph


818
2-F
Ac
3,5-diCF3—Ph


819
2-F
Ac
5-Cl-2-MeO—Ph


820
2-F
Ac
5-Cl-2-Me—Ph


821
2-F
Ac
2-F-5-Me—Ph


822
2-F
Ac
3-F-5-morpholino-Ph


823
2-F
Ac
3,4-OCH2O—Ph


824
2-F
Ac
3,4-OCH2CH2O—Ph


825
2-F
Ac
2-MeO-5-CONH2—Ph


826
2-F
Ac
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


827
2-F
Ac
2-MeO-5-(1-Me-5-tetrazolyl)-Ph


828
2-F
Ac
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


829
2-F
Ac
1-naphthyl


830
2-F
Ac
2-naphthyl


831
2-F
Ac
2-thienyl


832
2-F
Ac
3-thienyl


833
2-F
Ac
2-furanyl


834
2-F
Ac
3-furanyl


835
2-F
Ac
2-pyridyl


836
2-F
Ac
3-pyridyl


837
2-F
Ac
4-pyridyl


838
2-F
Ac
2-indolyl


839
2-F
Ac
3-indolyl


840
2-F
Ac
5-indolyl


841
2-F
Ac
6-indolyl


842
2-F
Ac
3-indazolyl


843
2-F
Ac
5-iridazolyl


844
2-F
Ac
6-indazolyl


845
2-F
Ac
2-imidazolyl


846
2-F
Ac
3-isoxazoyl


847
2-F
Ac
3-pyrazolyl


848
2-F
Ac
2-thiadiazolyl


849
2-F
Ac
2-thiazolyl


850
2-F
Ac
5-Ac-4-Me-2-thiazolyl


851
2-F
Ac
5-tetrazolyl


852
2-F
Ac
2-benzimidazolyl


853
2-F
Ac
5-benzimidazolyl


854
2-F
Ac
2-benzothiazolyl


855
2-F
Ac
5-benzothiazolyl


856
2-F
Ac
2-benzoxazolyl


857
2-F
Ac
5-benzoxazolyl


858
2-F
Ac
1-adamantyl


859
2-F
Ac
2-adamantyl


860
2-F
Ac
i-Pr


861
2-F
Ac
t-Bu


862
2-F
Ac
c-Hex


863
2-F
Ac
CH2CH2OMe


864
2-F
Ac
CH2CONH2


865
2-F
Ac
CH2CO2Me


866
2-F
Ac
CH(CH2Ph)CO2Me


867
2-F
Ac
CH2CH2NMe2


868
2-F
Ac
benzyl


869
2-F
Ac
phenethyl


870
2-F
Ac
2-(morpholin-1-yl)-Et


871
2-F
COtBu
Ph


872
2-F
COtBu
3-CN—Ph


873
2-F
COtBu
3-COMe—Ph


874
2-F
COtBu
3-CO2Me—Ph


875
2-F
COtBu
3-CONH2—Ph


876
2-F
COtBu
3-CONFiNe—Ph


877
2-F
COtBu
3-F—Ph


878
2-F
COtBu
3-Cl—Ph


879
2-F
COtBu
3-Br—Ph


880
2-F
COtBu
3-SO2NH2—Ph


881
2-F
COtBu
3-SO2NHMe—Ph


882
2-F
COtBu
3-CF3—Ph


883
2-F
COtBu
3-OMe—Ph


884
2-F
COtBu
3-SMe—Ph


885
2-F
COtBu
3-SOMe—Ph


886
2-F
COtBu
3-SO2Me—Ph


887
2-F
COtBu
3-OH—Ph


888
2-F
COtBu
3-CH2OH—Ph


889
2-F
COtBu
3-CHOHMe—Ph


890
2-F
COtBu
3-COH(Me)2—Ph


891
2-F
COtBu
3-Me—Ph


892
2-F
COtBu
3-Et—Ph


893
2-F
COtBu
3-iPr—Ph


894
2-F
COtBu
3-tBu—Ph


895
2-F
COtBu
3-CH2CO2Me—Ph


896
2-F
COtBu
3-(1-piperidinyl)-Ph


897
2-F
COtBu
3-(1-pyrrolidinyl)-Ph


898
2-F
COtBu
3-(2-imidazolyl)-Ph


899
2-F
COtBu
3-(1-iinidazolyl)-Ph


900
2-F
COtBu
3-(2-thiazolyl)-Ph


901
2-F
COtBu
3-(3-pyrazolyl)-Ph


902
2-F
COtBu
3-(1-pyrazolyl)-Ph


903
2-F
COtBu
3-(5-Me-1-tetrazolyl)-Ph


904
2-F
COtBu
3-(1-Me-5-tetrazolyl)-Ph


905
2-F
COtBu
3-(2-pyridyl)-Ph


906
2-F
COtBu
3-(2-thienyl)-Ph


907
2-F
COtBu
3-(2-furanyl)-Ph


908
2-F
COtBu
4-CN—Ph


909
2-F
COtBu
4-COMe—Ph


910
2-F
COtBu
4-CO2Me—Ph


911
2-F
COtBu
4-CONH2—Ph


912
2-F
COtBu
4-CONHNe—Ph


913
2-F
COtBu
4-CONHPh—Ph


914
2-F
COtBu
4-F—Ph


915
2-F
COtBu
4-Cl—Ph


916
2-F
COtBu
4-Br—Ph


917
2-F
COtBu
4-SO2NH2—Ph


918
2-F
COtBu
4-SO2NHMe—Ph


919
2-F
COtBu
4-CF3—Ph


920
2-F
COtBu
4-OMe—Ph


921
2-F
COtBu
4-SMe—Ph


922
2-F
COtBu
4-SOMe—Ph


923
2-F
COtBu
4-SO2Me—Ph


924
2-F
COtBu
4-OH—Ph


925
2-F
COtBu
4-CH2OH—Ph


926
2-F
COtBu
4-CHOHMe—Ph


927
2-F
COtBu
4-COH(Me)2—Ph


928
2-F
COtBu
4-Me—Ph


929
2-F
COtBu
4-Et—Ph


930
2-F
COtBu
4-iPr—Ph


931
2-F
COtBu
4-tBu—Ph


932
2-F
COtBu
4-CH2CO2Me—Ph


933
2-F
COtBu
4-(1-piperidinyl)-Ph


934
2-F
COtBu
4-(1-pyrrolidinyl)-Ph


935
2-F
COtBu
4-(2-imidazolyl)-Ph


936
2-F
COtBu
4-(1-imidazolyl)-Ph


937
2-F
COtBu
4-(2-thiazolyl)-Ph


938
2-F
COtBu
4-(3-pyrazolyl)-Ph


939
2-F
COtBu
4-(1-pyrazolyl)-Ph


940
2-F
COtBu
4-(5-Me-1-tetrazolyl)-Ph


941
2-F
COtBu
4-(1-Me-5-tetrazolyl)-Ph


942
2-F
COtBu
4-(2-pyridyl)-Ph


943
2-F
COtBu
4-(2-thienyl)-Ph


944
2-F
COtBu
4-(2-furanyl)-Ph


945
2-F
COtBu
2-CN—Ph


946
2-F
COtBu
2-COMe—Ph


947
2-F
COtBu
2-CO2Me—Ph


948
2-F
COtBu
2-CONH2—Ph


949
2-F
COtBu
2-CONHMe—Ph


950
2-F
COtBu
2-F—Ph


951
2-F
COtBu
2-Cl—Ph


952
2-F
COtBu
2-Br—Ph


953
2-F
COtBu
2-SO2NH2—Ph


954
2-F
COtBu
2-SO2NHMe—Ph


955
2-F
COtBu
2-CF3—Ph


956
2-F
COtBu
2-OMe—Ph


957
2-F
COtBu
2-SMe—Ph


958
2-F
COtBu
2-SOMe—Ph


959
2-F
COtBu
2-SO2Me—Ph


960
2-F
COtBu
2-OH—Ph


961
2-F
COtBu
2-CH2OH—Ph


962
2-F
COtBu
2-CHOHMe—Ph


963
2-F
COtBu
2-COH(Me)2—Ph


964
2-F
COtBu
2-Me—Ph


965
2-F
COtBu
2-Et—Ph


966
2-F
COtBu
2-iPr—Ph


967
2-F
COtBu
2-tBu—Ph


968
2-F
COtBu
2-CH2CO2Me—Ph


969
2-F
COtBu
2-(1-piperidinyl)-Ph


970
2-F
COtBu
2-(1-pyrrolidinyl)-Ph


971
2-F
COtBu
2-(2-imidazolyl)-Ph


972
2-F
COtBu
2-(1-imidazolyl)-Ph


973
2-F
COtBu
2-(2-thiazolyl)-Ph


974
2-F
COtBu
2-(3-pyrazolyl)-Ph


975
2-F
COtBu
2-(1-pyrazolyl)-Ph


976
2-F
COtBu
2-(5-Me-1-tetrazolyl)-Ph


977
2-F
COtBu
2-(1-Me-5-tetrazolyl)-Ph


978
2-F
COtBu
2-(2-pyridyl)-Ph


979
2-F
COtBu
2-(2-thienyl)-Ph


980
2-F
COtBu
2-(2-furanyl)-Ph


981
2-F
COtBu
2,4-diF—Ph


982
2-F
COtBu
2,5-diF—Ph


983
2-F
COtBu
2,6-diF—Ph


984
2-F
COtBu
3,4-diF—Ph


985
2-F
COtBu
3,5-diF—Ph


986
2-F
COtBu
2,4-diCl—Ph


987
2-F
COtBu
2,5-diCl—Ph


988
2-F
COtBu
2,6-diCl—Ph


989
2-F
COtBu
3,4-diCl—Ph


990
2-F
COtBu
3,5-diCl—Ph


991
2-F
COtBu
3,4-diCF3—Ph


992
2-F
COtBu
3,4-diCF3—Ph


993
2-F
COtBu
5-Cl-2-MeO—Ph


994
2-F
COtBu
5-Cl-2-Me—Ph


995
2-F
COtBu
2-F-5-Me—Ph


996
2-F
COtBu
3-F-5-morpholino-Ph


997
2-F
COtBu
3,4-OCH2O—Ph


998
2-F
COtBu
3,4-OCH2CH2O—Ph


999
2-F
COtBu
2-MeO-5-CONH2—Ph


1000
2-F
COtBu
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


1001
2-F
COtBu
2-MeO-5-(1-Me-5-tetrazolyl)-Ph


1002
2-F
COtBu
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


1003
2-F
COtBu
1-naphthyl


1004
2-F
COtBu
2-naphthyl


1005
2-F
COtBu
2-thienyl


1006
2-F
COtBu
3-thienyl


1007
2-F
COtBu
2-furanyl


1008
2-F
COtBu
3-furanyl


1009
2-F
COtBu
2-pyridyl


1010
2-F
COtBu
3-pyridyl


1011
2-F
COtBu
4-pyridyl


1012
2-F
COtBu
2-indolyl


1013
2-F
COtBu
3-indolyl


1014
2-F
COtBu
5-indolyl


1015
2-F
COtBu
6-iridolyl


1016
2-F
COtBu
3-indazolyl


1017
2-F
COtBu
5-indazolyl


1018
2-F
COtBu
6-indazolyl


1019
2-F
COtBu
2-imidazolyl


1020
2-F
COtBu
3-isoxazoyl


1021
2-F
COtBu
3-pyrazolyl


1022
2-F
COtBu
2-thiadiazolyl


1023
2-F
COtBu
2-thiazolyl


1024
2-F
COtBu
5-Ac-4-Me-2-thiazolyl


1025
2-F
COtBu
5-tetrazolyl


1026
2-F
COtBu
2-benzimidazolyl


1027
2-F
COtBu
5-benzimidazolyl


1028
2-F
COtBu
2-benzothiazolyl


1029
2-F
COtBu
5-benzothiazolyl


1030
2-F
COtBu
2-benzoxazolyl


1031
2-F
COtBu
5-benzoxazolyl


1032
2-F
COtBu
1-adamantyl


1033
2-F
COtBu
2-adamantyl


1034
2-F
COtBu
i-Pr


1035
2-F
COtBu
t-Bu


1036
2-F
COtBu
c-Hex


1037
2-F
COtBu
CH2CH2OMe


1038
2-F
COtBu
CH2CONH2


1039
2-F
COtBu
CH2CO2Me


1040
2-F
COtBu
CH(CH2Ph)CO2Me


1041
2-F
COtBu
CH2CH2NMe2


1042
2-F
COtBu
benzyl


1043
2-F
COtBu
phenethyl


1044
2-F
COtBu
2-(morpholin-1-yl)-Et


1045
2-F
SO2Me
Ph


1046
2-F
SO2Me
3-CN—Ph


1047
2-F
SO2Me
3-COMe—Ph


1048
2-F
SO2Me
3-CO2Me—Ph


1049
2-F
SO2Me
3-CONH2—Ph


1050
2-F
SO2Me
3-CONHMe—Ph


1051
2-F
SO2Me
3-F—Ph


1052
2-F
SO2Me
3-Cl—Ph


1053
2-F
SO2Me
3-Br—Ph


1054
2-F
SO2Me
3-SO2NH2—Ph


1055
2-F
SO2Me
3-SO2NHMe—Ph


1056
2-F
SO2Me
3-CF3—Ph


1057
2-F
SO2Me
3-OMe—Ph


1058
2-F
SO2Me
3-SMe—Ph


1059
2-F
SO2Me
3-SOMe—Ph


1060
2-F
SO2Me
3-SO2Me—Ph


1061
2-F
SO2Me
3-OH—Ph


1062
2-F
SO2Me
3-CH2OH—Ph


1063
2-F
SO2Me
3-CHOHMe—Ph


1064
2-F
SO2Me
3-COH(Me)2—Ph


1065
2-F
SO2Me
3-Me—Ph


1066
2-F
SO2Me
3-Et—Ph


1067
2-F
SO2Me
3-iPr—Ph


1068
2-F
SO2Me
3-tBu—Ph


1069
2-F
SO2Me
3-CH2CO2Me—Ph


1070
2-F
SO2Me
3-(1-piperidinyl)-Ph


1071
2-F
SO2Me
3-(1-pyrrolidinyl)-Ph


1072
2-F
SO2Me
3-(2-imidazolyl)-Ph


1073
2-F
SO2Me
3-(1-imidazolyl)-Ph


1074
2-F
SO2Me
3-(2-thiazolyl)-Ph


1075
2-F
SO2Me
3-(3-pyrazolyl)-Ph


1076
2-F
SO2Me
3-(1-pyrazolyl)-Ph


1077
2-F
SO2Me
3-(5-Me-1-tetrazolyl)-Ph


1078
2-F
SO2Me
3-(1-Me-5-tetrazolyl)-Ph


1079
2-F
SO2Me
3-(2-pyridyl)-Ph


1080
2-F
SO2Me
3-(2-thienyl)-Ph


1081
2-F
SO2Me
3-(2-furanyl)-Ph


1082
2-F
SO2Me
4-CN—Ph


1083
2-F
SO2Me
4-COMe—Ph


1084
2-F
SO2Me
4-CO2Me—Ph


1085
2-F
SO2Me
4-CONH2—Ph


1086
2-F
SO2Me
4-CONHMe—Ph


1087
2-F
SO2Me
4-CONHPh—Ph


1088
2-F
SO2Me
4-F—Ph


1089
2-F
SO2Me
4-Cl—Ph


1090
2-F
SO2Me
4-Br—Ph


1091
2-F
SO2Me
4-SO2NH2—Ph


1092
2-F
SO2Me
4-SO2NHMe—Ph


1093
2-F
SO2Me
4-CF3—Ph


1094
2-F
SO2Me
4-OMe—Ph


1095
2-F
SO2Me
4-SMe—Ph


1096
2-F
SO2Me
4-SOMe—Ph


1097
2-F
SO2Me
4-SO2Me—Ph


1098
2-F
SO2Me
4-OH—Ph


1099
2-F
SO2Me
4-CH2OH—Ph


1100
2-F
SO2Me
4-CHOHMe—Ph


1101
2-F
SO2Me
4-COH(Me)2—Ph


1102
2-F
SO2Me
4-Me—Ph


1103
2-F
SO2Me
4-Et—Ph


1104
2-F
SO2Me
4-iPr—Ph


1105
2-F
SO2Me
4-tBu—Ph


1106
2-F
SO2Me
4-CH2CO2Me—Ph


1107
2-F
SO2Me
4-(1-piperidinyl)-Ph


1108
2-F
SO2Me
4-(1-pyrrolidinyl)-Ph


1109
2-F
SO2Me
4-(2-imidazolyl)-Ph


1110
2-F
SO2Me
4-(1-imidazolyl)-Ph


1111
2-F
SO2Me
4-(2-thiazolyl)-Ph


1112
2-F
SO2Me
4-(3-pyrazolyl)-Ph


1113
2-F
SO2Me
4-(1-pyrazolyl)-Ph


1114
2-F
SO2Me
4-(5-Me-1-tetrazolyl)-Ph


1115
2-F
SO2Me
4-(1-Me-5-tetrazolyl)-Ph


1116
2-F
SO2Me
4-(2-pyridyl)-Ph


1117
2-F
SO2Me
4-(2-thienyl)-Ph


1118
2-F
SO2Me
4-(2-furanyl)-Ph


1119
2-F
SO2Me
2-CN—Ph


1120
2-F
SO2Me
2-COMe—Ph


1121
2-F
SO2Me
2-CO2Me—Ph


1122
2-F
SO2Me
2-CONH2—Ph


1123
2-F
SO2Me
2-CONHMe—Ph


1124
2-F
SO2Me
2-F—Ph


1125
2-F
SO2Me
2-Cl—Ph


1126
2-F
SO2Me
2-Br—Ph


1127
2-F
SO2Me
2-SO2NH2—Ph


1128
2-F
SO2Me
2-SO2NHMe—Ph


1129
2-F
SO2Me
2-CF3—Ph


1130
2-F
SO2Me
2-OMe—Ph


1131
2-F
SO2Me
2-SMe—Ph


1132
2-F
SO2Me
2-SOMe—Ph


1133
2-F
SO2Me
2-SO2Me—Ph


1134
2-F
SO2Me
2-OH—Ph


1135
2-F
SO2Me
2-CH2OH—Ph


1136
2-F
SO2Me
2-CHOHMe—Ph


1137
2-F
SO2Me
2-COH(Me)2—Ph


1138
2-F
SO2Me
2-Me—Ph


1139
2-F
SO2Me
2-Et—Ph


1140
2-F
SO2Me
2-iPr—Ph


1141
2-F
SO2Me
2-tBu—Ph


1142
2-F
SO2Me
2-CH2CO2Me—Ph


1143
2-F
SO2Me
2-(1-piperidinyl)-Ph


1144
2-F
SO2Me
2-(1-pyrrolidinyl)-Ph


1145
2-F
SO2Me
2-(2-imidazolyl)-Ph


1146
2-F
SO2Me
2-(1-imidazolyl)-Ph


1147
2-F
SO2Me
2-(2-thiazolyl)-Ph


1148
2-F
SO2Me
2-(3-pyrazolyl)-Ph


1149
2-F
SO2Me
2-(1-pyrazolyl)-Ph


1150
2-F
SO2Me
2-(5-Me-1-tetrazolyl)-Ph


1151
2-F
SO2Me
2-(1-Me-5-tetrazolyl)-Ph


1152
2-F
SO2Me
2-(2-pyridyl)-Ph


1153
2-F
SO2Me
2-(2-thienyl)-Ph


1154
2-F
SO2Me
2-(2-furanyl)-Ph


1155
2-F
SO2Me
2,4-diF—Ph


1156
2-F
SO2Me
2,5-diF—Ph


1157
2-F
SO2Me
2,6-diF—Ph


1158
2-F
SO2Me
3,4-diF—Ph


1159
2-F
SO2Me
3,5-diF—Ph


1160
2-F
SO2Me
2,4-diCl—Ph


1161
2-F
SO2Me
2,5-diCl—Ph


1162
2-F
SO2Me
2,6-diCl—Ph


1163
2-F
SO2Me
3,4-diCl—Ph


1164
2-F
SO2Me
3,5-diCl—Ph


1165
2-F
SO2Me
3,4-diCF3—Ph


1166
2-F
SO2Me
3,5-diCF3—Ph


1167
2-F
SO2Me
5-Cl-2-MeO—Ph


1168
2-F
SO2Me
5-Cl-2-Me—Ph


1169
2-F
SO2Me
2-F-5-Me—Ph


1170
2-F
SO2Me
3-F-5-morpholino-Ph


1171
2-F
SO2Me
3,4-OCH2O—Ph


1172
2-F
SO2Me
3,4-OCH2CH2O—Ph


1173
2-F
SO2Me
2-MeO-5-CONH2—Ph


1174
2-F
SO2Me
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


1175
2-F
SO2Me
2-NeO-5-(1-Me-5-tetrazolyl)-Ph


1176
2-F
SO2Me
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


1177
2-F
SO2Me
1-naphthyl


1178
2-F
SO2Me
2-naphthyl


1179
2-F
SO2Me
2-thienyl


1180
2-F
SO2Me
3-thienyl


1181
2-F
SO2Me
2-furanyl


1182
2-F
SO2Me
3-furanyl


1183
2-F
SO2Me
2-pyridyl


1184
2-F
SO2Me
3-pyridyl


1185
2-F
SO2Me
4-pyridyl


1186
2-F
SO2Me
2-indolyl


1187
2-F
SO2Me
3-indolyl


1188
2-F
SO2Me
5-indolyl


1189
2-F
SO2Me
6-indolyl


1190
2-F
SO2Me
3-indazolyl


1191
2-F
SO2Me
5-indazolyl


1192
2-F
SO2Me
6-indazolyl


1193
2-F
SO2Me
2-imidazolyl


1194
2-F
SO2Me
3-isoxazoyl


1195
2-F
SO2Me
3-pyrazolyl


1196
2-F
SO2Me
2-thiadiazolyl


1197
2-F
SO2Me
2-thiazolyl


1198
2-F
SO2Me
5-Ac-4-Me-2-thiazolyl


1199
2-F
SO2Me
5-tetrazolyl


1200
2-F
SO2Me
2-benzimidazolyl


1201
2-F
SO2Me
5-benzimidazolyl


1202
2-F
SO2Me
2-benzothiazolyl


1203
2-F
SO2Me
5-benzothiazolyl


1204
2-F
SO2Me
2-benzoxazolyl


1205
2-F
SO2Me
5-benzoxazolyl


1206
2-F
SO2Me
1-adamantyl


1207
2-F
SO2Me
2-adamantyl


1208
2-F
SO2Me
i-Pr


1209
2-F
SO2Me
t-Bu


1210
2-F
SO2Me
c-Hex


1211
2-F
SO2Me
CH2CH2OMe


1212
2-F
SO2Me
CH2CONH2


1213
2-F
SO2Me
CH2CO2Me


1214
2-F
SO2Me
CH(CH2Ph)CO2Me


1215
2-F
SO2Me
CH2CH2NMe2


1216
2-F
SO2Me
benzyl


1217
2-F
SO2Me
phenethyl


1218
2-F
SO2Me
2-(morpholin-1-yl)-Et


1219
2-F
CH2COMe
Ph


1220
2-F
CH2COMe
3-CN—Ph


1221
2-F
CH2COMe
3-COMe—Ph


1222
2-F
CH2COMe
3-CO2Me—Ph


1223
2-F
CH2COMe
3-CONH2—Ph


1224
2-F
CH2COMe
3-CONHMe—Ph


1225
2-F
CH2COMe
3-F—Ph


1226
2-F
CH2COMe
3-Cl—Ph


1227
2-F
CH2COMe
3-Br—Ph


1228
2-F
CH2COMe
3-SO2NH2—Ph


1229
2-F
CH2COMe
3-SO2NHMe—Ph


1230
2-F
CH2COMe
3-CF3—Ph


1231
2-F
CH2COMe
3-OMe—Ph


1232
2-F
CH2COMe
3-SMe—Ph


1233
2-F
CH2COMe
3-SOMe—Ph


1234
2-F
CH2COMe
3-SO2Me—Ph


1235
2-F
CH2COMe
3-OH—Ph


1236
2-F
CH2COMe
3-CH2OH—Ph


1237
2-F
CH2COMe
3-CHOHMe—Ph


1238
2-F
CH2COMe
3-COH(Me)2—Ph


1239
2-F
CH2COMe
3-Me—Ph


1240
2-F
CH2COMe
3-Et—Ph


1241
2-F
CH2COMe
3-iPr—Ph


1242
2-F
CH2COMe
3-tBu—Ph


1243
2-F
CH2COMe
3-CH2CO2Me—Ph


1244
2-F
CH2COMe
3-(1-piperidinyl)-Ph


1245
2-F
CH2COMe
3-(1-pyrrolidinyl)-Ph


1246
2-F
CH2COMe
3-(2-imidazolyl)-Ph


1247
2-F
CH2COMe
3-(1-imidazolyl)-Ph


1248
2-F
CH2COMe
3-(2-thiazolyl)-Ph


1249
2-F
CH2COMe
3-(3-pyrazolyl)-Ph


1250
2-F
CH2COMe
3-(1-pyrazolyl)-Ph


1251
2-F
CH2COMe
3-(5-Me-1-tetrazolyl)-Ph


1252
2-F
CH2COMe
3-(1-Me-5-tetrazolyl)-Ph


1253
2-F
CH2COMe
3-(2-pyridyl)-Ph


1254
2-F
CH2COMe
3-(2-thienyl)-Ph


1255
2-F
CH2COMe
3-(2-furanyl)-Ph


1256
2-F
CH2COMe
4-CN—Ph


1257
2-F
CH2COMe
4-COMe—Ph


1258
2-F
CH2COMe
4-CO2Me—Ph


1259
2-F
CH2COMe
4-CONH2—Ph


1260
2-F
CH2COMe
4-CONFINe—Ph


1261
2-F
CH2COMe
4-CONHPh—Ph


1262
2-F
CH2COMe
4-F—Ph


1263
2-F
CH2COMe
4-Cl—Ph


1264
2-F
CH2COMe
4-Br—Ph


1265
2-F
CH2COMe
4-SO2NH2—Ph


1266
2-F
CH2COMe
4-SO2NHMe—Ph


1267
2-F
CH2COMe
4-CF3—Ph


1268
2-F
CH2COMe
4-OMe—Ph


1269
2-F
CH2COMe
4-SMe—Ph


1270
2-F
CH2COMe
4-SOMe—Ph


1271
2-F
CH2COMe
4-SO2Me—Ph


1272
2-F
CH2COMe
4-OH—Ph


1273
2-F
CH2COMe
4-CH2OH—Ph


1274
2-F
CH2COMe
4-CHOHMe—Ph


1275
2-F
CH2COMe
4-COH(Me)2—Ph


1276
2-F
CH2COMe
4-Me—Ph


1277
2-F
CH2COMe
4-Et—Ph


1278
2-F
CH2COMe
4-iPr—Ph


1279
2-F
CH2COMe
4-tBu—Ph


1280
2-F
CH2COMe
4-CH2CO2Me—Ph


1281
2-F
CH2COMe
4-(1-piperidinyl)-Ph


1282
2-F
CH2COMe
4-(1-pyrrolidinyl)-Ph


1283
2-F
CH2COMe
4-(2-imidazolyl)-Ph


1284
2-F
CH2COMe
4-(1-imidazolyl)-Ph


1285
2-F
CH2COMe
4-(2-thiazolyl)-Ph


1286
2-F
CH2COMe
4-(3-pyrazolyl)-Ph


1287
2-F
CH2COMe
4-(1-pyrazolyl)-Ph


1288
2-F
CH2COMe
4-(5-Me-1-tetrazolyl)-Ph


1289
2-F
CH2COMe
4-(1-Me-5-tetrazolyl)-Ph


1290
2-F
CH2COMe
4-(2-pyridyl)-Ph


1291
2-F
CH2COMe
4-(2-thienyl)-Ph


1292
2-F
CH2COMe
4-(2-furanyl)-Ph


1293
2-F
CH2COMe
2-CN—Ph


1294
2-F
CH2COMe
2-COMe—Ph


1295
2-F
CH2COMe
2-CO2Me—Ph


1296
2-F
CH2COMe
2-CONH2—Ph


1297
2-F
CH2COMe
2-CONHMe—Ph


1298
2-F
CH2COMe
2-F—Ph


1299
2-F
CH2COMe
2-Cl—Ph


1300
2-F
CH2COMe
2-Br—Ph


1301
2-F
CH2COMe
2-SO2NH2—Ph


1302
2-F
CH2COMe
2-SO2NHMe—Ph


1303
2-F
CH2COMe
2-CF3—Ph


1304
2-F
CH2COMe
2-OMe—Ph


1305
2-F
CH2COMe
2-SMe—Ph


1306
2-F
CH2COMe
2-SOMe—Ph


1307
2-F
CH2COMe
2-SO2Me—Ph


1308
2-F
CH2COMe
2-OH—Ph


1309
2-F
CH2COMe
2-CH2OH—Ph


1310
2-F
CH2COMe
2-CHOHMe—Ph


1311
2-F
CH2COMe
2-COH(Me)2—Ph


1312
2-F
CH2COMe
2-Me—Ph


1313
2-F
CH2COMe
2-Et—Ph


1314
2-F
CH2COMe
2-iPr—Ph


1315
2-F
CH2COMe
2-tBu—Ph


1316
2-F
CH2COMe
2-CH2CO2Ne—Ph


1317
2-F
CH2COMe
2-(1-piperidinyl)-Ph


1318
2-F
CH2COMe
2-(1-pyrrolidinyl)-Ph


1319
2-F
CH2COMe
2-(2-imidazolyl)-Ph


1320
2-F
CH2COMe
2-(1-imidiazolyl)-Ph


1321
2-F
CH2COMe
2-(2-thiazolyl)-Ph


1322
2-F
CH2COMe
2-(3-pyrazolyl)-Ph


1323
2-F
CH2COMe
2-(1-pyrazolyl)-Ph


1324
2-F
CH2COMe
2-(5-Me-1-tetrazolyl)-Ph


1325
2-F
CH2COMe
2-(1-Me-5-tetrazolyl)-Ph


1326
2-F
CH2COMe
2-(2-pyridyl)-Ph


1327
2-F
CH2COMe
2-(2-thienyl)-Ph


1328
2-F
CH2COMe
2-(2-furanyl)-Ph


1329
2-F
CH2COMe
2,4-diF—Ph


1330
2-F
CH2COMe
2,5-diF—Ph


1331
2-F
CH2COMe
2,6-diF—Ph


1332
2-F
CH2COMe
3,4-diF—Ph


1333
2-F
CH2COMe
3,5-diF—Ph


1334
2-F
CH2COMe
2,4-diCl—Ph


1335
2-F
CH2COMe
2,5-diCl—Ph


1336
2-F
CH2COMe
2,6-diCl—Ph


1337
2-F
CH2COMe
3, 4-diCl—Ph


1338
2-F
CH2COMe
3,5-diCl—Ph


1339
2-F
CH2COMe
3,4-diCF3—Ph


1340
2-F
CH2COMe
3,5-diCF3—Ph


1341
2-F
CH2COMe
5-Cl-2-MeO—Ph


1342
2-F
CH2COMe
5-Cl-2-Me—Ph


1343
2-F
CH2COMe
2-F-5-Me—Ph


1344
2-F
CH2COMe
3-F-5-morpholino-Ph


1345
2-F
CH2COMe
3,4-OCH2O—Ph


1346
2-F
CH2COMe
3,4-OCH2CH2O—Ph


1347
2-F
CH2COMe
2-MeO-5-CONH2—Ph


1348
2-F
CH2COMe
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


1349
2-F
CH2COMe
2-MeO-5-(1-Me-5-tetrazolyl)-Ph


1350
2-F
CH2COMe
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


1351
2-F
CH2COMe
1-naphthyl


1352
2-F
CH2COMe
2-naphthyl


1353
2-F
CH2COMe
2-thienyl


1354
2-F
CH2COMe
3-thienyl


1355
2-F
CH2COMe
2-furanyl


1356
2-F
CH2COMe
3-furanyl


1357
2-F
CH2COMe
2-pyridyl


1358
2-F
CH2COMe
3-pyridyl


1359
2-F
CH2COMe
4-pyridyl


1360
2-F
CH2COMe
2-indolyl


1361
2-F
CH2COMe
3-indolyl


1362
2-F
CH2COMe
5-indolyl


1363
2-F
CH2COMe
6-indalyl


1364
2-F
CH2COMe
3-indazolyl


1365
2-F
CH2COMe
5-indazolyl


1366
2-F
CH2COMe
6-indazolyl


1367
2-F
CH2COMe
2-imidazolyl


1368
2-F
CH2COMe
3-isoxazoyl


1369
2-F
CH2COMe
3-pyrazolyl


1370
2-F
CH2COMe
2-thiadiazolyl


1371
2-F
CH2COMe
2-thiazolyl


1372
2-F
CH2COMe
5-Ac-4-Me-2-thiazolyl


1373
2-F
CH2COMe
5-tetrazolyl


1374
2-F
CH2COMe
2-benzimidazolyl


1375
2-F
CH2COMe
5-benzimidazolyl


1376
2-F
CH2COMe
2-benzothiazolyl


1377
2-F
CH2COMe
5-benzothiazolyl


1378
2-F
CH2COMe
2-benzoxazolyl


1379
2-F
CH2COMe
5-benzoxazolyl


1380
2-F
CH2COMe
1-adamantyl


1381
2-F
CH2COMe
2-adamantyl


1382
2-F
CH2COMe
i-Pr


1383
2-F
CH2COMe
t-Bu


1384
2-F
CH2COMe
c-Hex


1385
2-F
CH2COMe
CH2CH2OMe


1386
2-F
CH2COMe
CH2CONH2


1387
2-F
CH2COMe
CH2CO2Me


1388
2-F
CH2COMe
CH(CH2Ph)CO2Me


1389
2-F
CH2COMe
CH2CH2NMe2


1390
2-F
CH2COMe
benzyl


1391
2-F
CH2COMe
phenethyl


1392
2-F
CH2COMe
2-(morpholin-1-yl)-Et


1393
3-F
H
Ph


1394
3-F
H
3-CN—Ph


1395
3-F
H
3-COMe—Ph


1396
3-F
H
3-CO2Me—Ph


1397
3-F
H
3-CONH2—Ph


1398
3-F
H
3-CONHMe—Ph


1399
3-F
H
3-F—Ph


1400
3-F
H
3-Cl—Ph


1401
3-F
H
3-Br—Ph


1402
3-F
H
3-SO2NH2—Ph


1403
3-F
H
3-SO2NHMe—Ph


1404
3-F
H
3-CF3—Ph


1405
3-F
H
3-OMe—Ph


1406
3-F
H
3-SMe—Ph


1407
3-F
H
3-SOMe—Ph


1408
3-F
H
3-SO2Me—Ph


1409
3-F
H
3-OH—Ph


1410
3-F
H
3-CH2OH—Ph


1411
3-F
H
3-CHOHMe—Ph


1412
3-F
H
3-COH(Me)2—Ph


1413
3-F
H
3-Me—Ph


1414
3-F
H
3-Et—Ph


1415
3-F
H
3-iPr—Ph


1416
3-F
H
3-tBu—Ph


1417
3-F
H
3-CH2CO2Me—Ph


1418
3-F
H
3-(1-piperidinyl)-Ph


1419
3-F
H
3-(1-pyrrolidinyl)-Ph


1420
3-F
H
3-(2-imidazolyl)-Ph


1421
3-F
H
3-(1-imidazolyl)-Ph


1422
3-F
H
3-(2-thiazolyl)-Ph


1423
3-F
H
3-(3-pyrazolyl)-Ph


1424
3-F
H
3-(1-pyrazolyl)-Ph


1425
3-F
H
3-(5-Me-1-tetrazolyl)-Ph


1426
3-F
H
3-(1-Me-5-tetrazolyl)-Ph


1427
3-F
H
3-(2-pyridyl)-Ph


1428
3-F
H
3-(2-thienyl)-Ph


1429
3-F
H
3-(2-furanyl)-Ph


1430
3-F
H
4-CN—Ph


1431
3-F
H
4-COMe—Ph


1432
3-F
H
4-CO2Me—Ph


1433
3-F
H
4-CONH2—Ph


1434
3-F
H
4-CONHMe—Ph


1435
3-F
H
4-CONHPh—Ph


1436
3-F
H
4-F—Ph


1437
3-F
H
4-Cl—Ph


1438
3-F
H
4-Br—Ph


1439
3-F
H
4-SO2NH2—Ph


1440
3-F
H
4-SO2NHMe—Ph


1441
3-F
H
4-CF3—Ph


1442
3-F
H
4-OMe—Ph


1443
3-F
H
4-SMe—Ph


1444
3-F
H
4-SOMe—Ph


1445
3-F
H
4-SO2Me—Ph


1446
3-F
H
4-OH—Ph


1447
3-F
H
4-CH2OH—Ph


1448
3-F
H
4-CHOHMe—Ph


1449
3-F
H
4-COH(Me)2—Ph


1450
3-F
H
4-Me—Ph


1451
3-F
H
4-Et—Ph


1452
3-F
H
4-iPr—Ph


1453
3-F
H
4-tBu—Ph


1454
3-F
H
4-CH2CO2Me—Ph


1455
3-F
H
4-(1-piperidinyl)-Ph


1456
3-F
H
4-(1-pyrrolidinyl)-Ph


1457
3-F
H
4-(2-imidazolyl)-Ph


1458
3-F
H
4-(1-imidazolyl)-Ph


1459
3-F
H
4-(2-thiazolyl)-Ph


1460
3-F
H
4-(3-pyrazolyl)-Ph


1461
3-F
H
4-(1-pyrazolyl)-Ph


1462
3-F
H
4-(5-Me-1-tetrazolyl)-Ph


1463
3-F
H
4-(1-Me-5-tetrazolyl)-Ph


1464
3-F
H
4-(2-pyridyl)-Ph


1465
3-F
H
4-(2-thienyl)-Ph


1466
3-F
H
4-(2-furanyl)-Ph


1467
3-F
H
2-CN—Ph


1468
3-F
H
2-COMe—Ph


1469
3-F
H
2-CO2Me—Ph


1470
3-F
H
2-CONH2—Ph


1471
3-F
H
2-CONHMe—Ph


1472
3-F
H
2-F—Ph


1473
3-F
H
2-Cl—Ph


1474
3-F
H
2-Br—Ph


1475
3-F
H
2-SO2NH2—Ph


1476
3-F
H
2-SO2NHMe—Ph


1477
3-F
H
2-CF3—Ph


1478
3-F
H
2-OMe—Ph


1479
3-F
H
2-SMe—Ph


1480
3-F
H
2-SOMe—Ph


1481
3-F
H
2-SO2Me—Ph


1482
3-F
H
2-OH—Ph


1483
3-F
H
2-CH2OH—Ph


1484
3-F
H
2-CHOHMe—Ph


1485
3-F
H
2-COH(Me)2—Ph


1486
3-F
H
2-Me—Ph


1487
3-F
H
2-Et—Ph


1488
3-F
H
2-iPr—Ph


1489
3-F
H
2-tBu—Ph


1490
3-F
H
2-CH2CO2Me—Ph


1491
3-F
H
2-(1-piperidinyl)-Ph


1492
3-F
H
2-(1-pyrrolidinyl)-Ph


1493
3-F
H
2-(2-imidazolyl)-Ph


1494
3-F
H
2-(1-imidazolyl)-Ph


1495
3-F
H
2-(2-thiazolyl)-Ph


1496
3-F
H
2-(3-pyrazolyl)-Ph


1497
3-F
H
2-(1-pyrazolyl)-Ph


1498
3-F
H
2-(5-Me-1-tetrazolyl)-Ph


1499
3-F
H
2-(1-Me-5-tetrazolyl)-Ph


1500
3-F
H
2-(2-pyridyl)-Ph


1501
3-F
H
2-(2-thienyl)-Ph


1502
3-F
H
2-(2-furanyl)-Ph


1503
3-F
H
2,4-diF—Ph


1504
3-F
H
2,5-diF—Ph


1505
3-F
H
2,6-diF—Ph


1506
3-F
H
3,4-diF—Ph


1507
3-F
H
3,5-diF—Ph


1508
3-F
H
2,4-diCl—Ph


1509
3-F
H
2,5-diCl—Ph


1510
3-F
H
2,6-diCl—Ph


1511
3-F
H
3,4-diCl—Ph


1512
3-F
H
3,5-diCl—Ph


1513
3-F
H
3,4-diCF3—Ph


1514
3-F
H
3,5-diCF3—Ph


1515
3-F
H
5-Cl-2-MeO—Ph


1516
3-F
H
5-Cl-2-Me—Ph


1517
3-F
H
2-F-5-Me—Ph


1518
3-F
H
3-F-5-morpholino-Ph


1519
3-F
H
3,4-OCH2O—Ph


1520
3-F
H
3,4-OCH2CH2O—Ph


1521
3-F
H
2-MeO-5-CONH2—Ph


1522
3-F
H
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


1523
3-F
H
2-MeO-5-(1-Me-5-tetrazolyl)-Ph


1524
3-F
H
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


1525
3-F
H
1-naphthyl


1526
3-F
H
2-naphthyl


1527
3-F
H
2-thienyl


1528
3-F
H
3-thienyl


1529
3-F
H
2-furanyl


1530
3-F
H
3-furanyl


1531
3-F
H
2-pyridyl


1532
3-F
H
3-pyridyl


1533
3-F
H
4-pyridyl


1534
3-F
H
2-indolyl


1535
3-F
H
3-indolyl


1536
3-F
H
5-indolyl


1537
3-F
H
6-indolyl


1538
3-F
H
3-indazolyl


1539
3-F
H
5-indazolyl


1540
3-F
H
6-indazolyl


1541
3-F
H
2-imidazolyl


1542
3-F
H
3-isoxazoyl


1543
3-F
H
3-pyrazolyl


1544
3-F
H
2-thiadiazolyl


1545
3-F
H
2-thiazolyl


1546
3-F
H
5-Ac-4-Me-2-thiazolyl


1547
3-F
H
5-tetrazolyl


1548
3-F
H
2-benzimidazolyl


1549
3-F
H
5-benzimidazolyl


1550
3-F
H
2-benzothiazolyl


1551
3-F
H
5-benzothiazolyl


1552
3-F
H
2-benzoxazolyl


1553
3-F
H
5-benzoxazolyl


1554
3-F
H
1-adamantyl


1555
3-F
H
2-adamantyl


1556
3-F
H
i-Pr


1557
3-F
H
t-Bu


1558
3-F
H
c-Hex


1559
3-F
H
CH2CH2OMe


1560
3-F
H
CH2CONH2


1561
3-F
H
CH2CO2Me


1562
3-F
H
CH(CH2Ph)CO2Me


1563
3-F
H
CH2CH2NMe2


1564
3-F
H
benzyl


1565
3-F
H
phenethyl


1566
3-F
H
2-(morpholin-1-yl)-Et


1567
3-F
Me
Ph


1568
3-F
Me
3-CN—Ph


1569
3-F
Me
3-COMe—Ph


1570
3-F
Me
3-CO2Me—Ph


1571
3-F
Me
3-CONH2—Ph


1572
3-F
Me
3-CONHMe—Ph


1573
3-F
Me
3-F—Ph


1574
3-F
Me
3-Cl—Ph


1575
3-F
Me
3-Br—Ph


1576
3-F
Me
3-SO2NH2—Ph


1577
3-F
Me
3-SO2NHMe—Ph


1578
3-F
Me
3-CF3—Ph


1579
3-F
Me
3-OMe—Ph


1580
3-F
Me
3-SMe—Ph


1581
3-F
Me
3-SOMe—Ph


1582
3-F
Me
3-SO2Me—Ph


1583
3-F
Me
3-OH—Ph


1584
3-F
Me
3-CH2OH—Ph


1585
3-F
Me
3-CHOHMe—Ph


1586
3-F
Me
3-COH(Me)2—Ph


1587
3-F
Me
3-Me—Ph


1588
3-F
Me
3-Et—Ph


1589
3-F
Me
3-iPr—Ph


1590
3-F
Me
3-tBu—Ph


1591
3-F
Me
3-CH2CO2Me—Ph


1592
3-F
Me
3-(1-piperidinyl)-Ph


1593
3-F
Me
3-(1-pyrrolidinyl)-Ph


1594
3-F
Me
3-(2-imidazolyl)-Ph


1595
3-F
Me
3-(1-imidazolyl)-Ph


1596
3-F
Me
3-(2-thiazolyl)-Ph


1597
3-F
Me
3-(3-pyrazolyl)-Ph


1598
3-F
Me
3-(1-pyrazolyl)-Ph


1599
3-F
Me
3-(5-Me-1-tetrazolyl)-Ph


1600
3-F
Me
3-(1-Me-5-tetrazolyl)-Ph


1601
3-F
Me
3-(2-pyridyl)-Ph


1602
3-F
Me
3-(2-thienyl)-Ph


1603
3-F
Me
3-(2-furanyl)-Ph


1604
3-F
Me
4-CN—Ph


1605
3-F
Me
4-COMe—Ph


1606
3-F
Me
4-CO2Me—Ph


1607
3-F
Me
4-CONH2—Ph


1608
3-F
Me
4-CONHMe—Ph


1609
3-F
Me
4-CONHPh—Ph


1610
3-F
Me
4-F—Ph


1611
3-F
Me
4-Cl—Ph


1612
3-F
Me
4-Br—Ph


1613
3-F
Me
4-SO2NH2—Ph


1614
3-F
Me
4-SO2NHMe—Ph


1615
3-F
Me
4-CF3—Ph


1616
3-F
Me
4-OMe—Ph


1617
3-F
Me
4-SMe—Ph


1618
3-F
Me
4-SOMe—Ph


1619
3-F
Me
4-SO2Me—Ph


1620
3-F
Me
4-OH—Ph


1621
3-F
Me
4-CH2OH—Ph


1622
3-F
Me
4-CHOHMe—Ph


1623
3-F
Me
4-COH(Me)2—Ph


1624
3-F
Me
4-Me—Ph


1625
3-F
Me
4-Et—Ph


1626
3-F
Me
4-iPr—Ph


1627
3-F
Me
4-tBu—Ph


1628
3-F
Me
4-CH2CO2Me—Ph


1629
3-F
Me
4-(1-piperidinyl)-Ph


1630
3-F
Me
4-(1-pyrrolidinyl)-Ph


1631
3-F
Me
4-(2-imidazolyl)-Ph


1632
3-F
Me
4-(1-imidazolyl)-Ph


1633
3-F
Me
4-(2-thiazolyl)-Ph


1634
3-F
Me
4-(3-pyrazolyl)-Ph


1635
3-F
Me
4-(1-pyrazolyl)-Ph


1636
3-F
Me
4-(5-Me-1-tetrazolyl)-Ph


1637
3-F
Me
4-(1-Me-5-tetrazolyl)-Ph


1638
3-F
Me
4-(2-pyridyl)-Ph


1639
3-F
Me
4-(2-thienyl)-Ph


1640
3-F
Me
4-(2-furanyl)-Ph


1641
3-F
Me
2-CN—Ph


1642
3-F
Me
2-COMe—Ph


1643
3-F
Me
2-CO2Me—Ph


1644
3-F
Me
2-CONH2—Ph


1645
3-F
Me
2-CONHMe—Ph


1646
3-F
Me
2-F—Ph


1647
3-F
Me
2-Cl—Ph


1648
3-F
Me
2-Br—Ph


1649
3-F
Me
2-SO2NH2—Ph


1650
3-F
Me
2-SO2NHMe—Ph


1651
3-F
Me
2-CF3—Ph


1652
3-F
Me
2-OMe—Ph


1653
3-F
Me
2-SMe—Ph


1654
3-F
Me
2-SOMe—Ph


1655
3-F
Me
2-SO2Me—Ph


1656
3-F
Me
2-OH—Ph


1657
3-F
Me
2-CH2OH—Ph


1658
3-F
Me
2-CHOHMe—Ph


1659
3-F
Me
2-COH(Me)2—Ph


1660
3-F
Me
2-Me—Ph


1661
3-F
Me
2-Et—Ph


1662
3-F
Me
2-iPr—Ph


1663
3-F
Me
2-tBu—Ph


1664
3-F
Me
2-CH2CO2Me—Ph


1665
3-F
Me
2-(1-piperidinyl)-Ph


1666
3-F
Me
2-(1-pyrrolidinyl)-Ph


1667
3-F
Me
2-(2-imidazolyl)-Ph


1668
3-F
Me
2-(1-imidazolyl)-Ph


1669
3-F
Me
2-(2-thiazolyl)-Ph


1670
3-F
Me
2-(3-pyrazolyl)-Ph


1671
3-F
Me
2-(1-pyrazolyl)-Ph


1672
3-F
Me
2-(5-Me-1-tetrazolyl)-Ph


1673
3-F
Me
2-(1-Me-5-tetrazolyl)-Ph


1674
3-F
Me
2-(2-pyridyl)-Ph


1675
3-F
Me
2-(2-thienyl)-Ph


1676
3-F
Me
2-(2-furanyl)-Ph


1677
3-F
Me
2,4-diF—Ph


1678
3-F
Me
2,5-diF—Ph


1679
3-F
Me
2,6-diF—Ph


1680
3-F
Me
3,4-diF—Ph


1681
3-F
Me
3,5-diF—Ph


1682
3-F
Me
2,4-diCl—Ph


1683
3-F
Me
2,5-diCl—Ph


1684
3-F
Me
2,6-diCl—Ph


1685
3-F
Me
3,4-diCl—Ph


1686
3-F
Me
3,5-diCl—Ph


1687
3-F
Me
3,4-diCF3—Ph


1688
3-F
Me
3,5-diCF3—Ph


1689
3-F
Me
5-Cl-2-MeO—Ph


1690
3-F
Me
5-Cl-2-Me—Ph


1691
3-F
Me
2-F-5-Me—Ph


1692
3-F
Me
3-F-5-morpholino-Ph


1693
3-F
Me
3,4-OCH2O—Ph


1694
3-F
Me
3,4-OCH2CH2O—Ph


1695
3-F
Me
2-MeO-5-CONH2—Ph


1696
3-F
Me
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


1697
3-F
Me
2-MeO-5-(1-Me-5-tetrazolyl)-Ph


1698
3-F
Me
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


1699
3-F
Me
1-naphthyl


1700
3-F
Me
2-naphthyl


1701
3-F
Me
2-thienyl


1702
3-F
Me
3-thienyl


1703
3-F
Me
2-furanyl


1704
3-F
Me
3-furanyl


1705
3-F
Me
2-pyridyl


1706
3-F
Me
3-pyridyl


1707
3-F
Me
4-pyridyl


1708
3-F
Me
2-indolyl


1709
3-F
Me
3-indolyl


1710
3-F
Me
5-indolyl


1711
3-F
Me
6-indolyl


1712
3-F
Me
3-indazolyl


1713
3-F
Me
5-indazolyl


1714
3-F
Me
6-indazolyl


1715
3-F
Me
2-imidazolyl


1716
3-F
Me
3-isoxazoyl


1717
3-F
Me
3-pyrazolyl


1718
3-F
Me
2-thiadiazolyl


1719
3-F
Me
2-thiazolyl


1720
3-F
Me
5-Ac-4-Me-2-thiazolyl


1721
3-F
Me
5-tetrazolyl


1722
3-F
Me
2-benzimidazolyl


1723
3-F
Me
5-benzimidazolyl


1724
3-F
Me
2-benzothiazolyl


1725
3-F
Me
5-benzothiazolyl


1726
3-F
Me
2-benzoxazolyl


1727
3-F
Me
5-benzoxazolyl


1728
3-F
Me
1-adamantyl


1729
3-F
Me
2-adamantyl


1730
3-F
Me
i-Pr


1731
3-F
Me
t-Bu


1732
3-F
Me
c-Hex


1733
3-F
Me
CH2CH2OMe


1734
3-F
Me
CH2CONH2


1735
3-F
Me
CH2CO2Me


1736
3-F
Me
CH(CH2Ph)CO2Me


1737
3-F
Me
CH2CH2NMe2


1738
3-F
Me
benzyl


1739
3-F
Me
phenethyl


1740
3-F
Me
2-(morpholin-1-yl)-Et


1741
3-F
2-F—Et
Ph


1742
3-F
2-F—Et
3-CN—Ph


1743
3-F
2-F—Et
3-COMe—Ph


1744
3-F
2-F—Et
3-CO2Me—Ph


1745
3-F
2-F—Et
3-CONH2—Ph


1746
3-F
2-F—Et
3-CONHMe—Ph


1747
3-F
2-F—Et
3-F—Ph


1748
3-F
2-F—Et
3-Cl—Ph


1749
3-F
2-F—Et
3-Br—Ph


1750
3-F
2-F—Et
3-SO2NH2—Ph


1751
3-F
2-F—Et
3-SO2NHMe—Ph


1752
3-F
2-F—Et
3-CF3—Ph


1753
3-F
2-F—Et
3-OMe—Ph


1754
3-F
2-F—Et
3-SMe—Ph


1755
3-F
2-F—Et
3-SOMe—Ph


1756
3-F
2-F—Et
3-SO2Me—Ph


1757
3-F
2-F—Et
3-OH—Ph


1758
3-F
2-F—Et
3-CH2OH—Ph


1759
3-F
2-F—Et
3-CHOHMe—Ph


1760
3-F
2-F—Et
3-COH(Me)2—Ph


1761
3-F
2-F—Et
3-Me—Ph


1762
3-F
2-F—Et
3-Et—Ph


1763
3-F
2-F—Et
3-iPr—Ph


1764
3-F
2-F—Et
3-tBu—Ph


1765
3-F
2-F—Et
3-CH2CO2Me—Ph


1766
3-F
2-F—Et
3-(1-piperidinyl)-Ph


1767
3-F
2-F—Et
3-(1-pyrrolidinyl)-Ph


1768
3-F
2-F—Et
3-(2-imidazolyl)-Ph


1769
3-F
2-F—Et
3-(1-imidazolyl)-Ph


1770
3-F
2-F—Et
3-(2-thiazolyl)-Ph


1771
3-F
2-F—Et
3-(3-pyrazolyl)-Ph


1772
3-F
2-F—Et
3-(1-pyrazolyl)-Ph


1773
3-F
2-F—Et
3-(5-Me-1-tetrazolyl)-Ph


1774
3-F
2-F—Et
3-(1-Me-5-tetrazolyl)-Ph


1775
3-F
2-F—Et
3-(2-pyridyl)-Ph


1776
3-F
2-F—Et
3-(2-thienyl)-Ph


1777
3-F
2-F—Et
3-(2-furanyl)-Ph


1778
3-F
2-F—Et
4-CN—Ph


1779
3-F
2-F—Et
4-COMe—Ph


1780
3-F
2-F—Et
4-CO2Me—Ph


1781
3-F
2-F—Et
4-CONH2—Ph


1782
3-F
2-F—Et
4-CONHMe—Ph


1783
3-F
2-F—Et
4-CONHPh—Ph


1784
3-F
2-F—Et
4-F—Ph


1785
3-F
2-F—Et
4-Cl—Ph


1786
3-F
2-F—Et
4-Br—Ph


1787
3-F
2-F—Et
4-SO2NH2—Ph


1788
3-F
2-F—Et
4-SO2NHMe—Ph


1789
3-F
2-F—Et
4-CF3—Ph


1790
3-F
2-F—Et
4-OMe—Ph


1791
3-F
2-F—Et
4-SMe—Ph


1792
3-F
2-F—Et
4-SOMe—Ph


1793
3-F
2-F—Et
4-SO2Me—Ph


1794
3-F
2-F—Et
4-OH—Ph


1795
3-F
2-F—Et
4-CH2OH—Ph


1796
3-F
2-F—Et
4-CHOHMe—Ph


1797
3-F
2-F—Et
4-COH(Me)2—Ph


1798
3-F
2-F—Et
4-Me—Ph


1799
3-F
2-F—Et
4-Et—Ph


1800
3-F
2-F—Et
4-iPr—Ph


1801
3-F
2-F—Et
4-tBu—Ph


1802
3-F
2-F—Et
4-CH2CO2Me—Ph


1803
3-F
2-F—Et
4-(1-piperidinyl)-Ph


1804
3-F
2-F—Et
4-(1-pyrrolidinyl)-Ph


1805
3-F
2-F—Et
4-(2-imidazolyl)-Ph


1806
3-F
2-F—Et
4-(1-imidazolyl)-Ph


1807
3-F
2-F—Et
4-(2-thiazolyl)-Ph


1808
3-F
2-F—Et
4-(3-pyrazolyl)-Ph


1809
3-F
2-F—Et
4-(1-pyrazolyl)-Ph


1810
3-F
2-F—Et
4-(5-Me-1-tetrazolyl)-Ph


1811
3-F
2-F—Et
4-(1-Me-5-tetrazolyl)—Ph


1812
3-F
2-F—Et
4-(2-pyridyl)-Ph


1813
3-F
2-F—Et
4-(2-thienyl)-Ph


1814
3-F
2-F—Et
4-(2-furanyl)-Ph


1815
3-F
2-F—Et
2-CN—Ph


1816
3-F
2-F—Et
2-COMe—Ph


1817
3-F
2-F—Et
2-CO2Me—Ph


1818
3-F
2-F—Et
2-CONH2—Ph


1819
3-F
2-F—Et
2-CONHMe—Ph


1820
3-F
2-F—Et
2-F—Ph


1821
3-F
2-F—Et
2-Cl—Ph


1822
3-F
2-F—Et
2-Br—Ph


1823
3-F
2-F—Et
2-SO2NH2—Ph


1824
3-F
2-F—Et
2-SO2NHMe—Ph


1825
3-F
2-F—Et
2-CF3—Ph


1826
3-F
2-F—Et
2-OMe—Ph


1827
3-F
2-F—Et
2-SMe—Ph


1828
3-F
2-F—Et
2-SOMe—Ph


1829
3-F
2-F—Et
2-SO2Me—Ph


1830
3-F
2-F—Et
2-OH—Ph


1831
3-F
2-F—Et
2-CH2OH—Ph


1832
3-F
2-F—Et
2-CHOHMe—Ph


1833
3-F
2-F—Et
2-COH(Me)2—Ph


1834
3-F
2-F—Et
2-Me—Ph


1835
3-F
2-F—Et
2-Et—Ph


1836
3-F
2-F—Et
2-iPr—Ph


1837
3-F
2-F—Et
2-tBu—Ph


1838
3-F
2-F—Et
2-CH2CO2Me—Ph


1839
3-F
2-F—Et
2-(1-piperidinyl)-Ph


1840
3-F
2-F—Et
2-(1-pyrrolidinyl)-Ph


1841
3-F
2-F—Et
2-(2-imidazolyl)-Ph


1842
3-F
2-F—Et
2-(1-imidazolyl)-Ph


1843
3-F
2-F—Et
2-(2-thiazolyl)-Ph


1844
3-F
2-F—Et
2-(3-pyrazolyl)-Ph


1845
3-F
2-F—Et
2-(1-pyrazolyl)-Ph


1846
3-F
2-F—Et
2-(5-Me-1-tetrazolyl)-Ph


1847
3-F
2-F—Et
2-(1-Me-5-tetrazolyl)-Ph


1848
3-F
2-F—Et
2-(2-pyridyl)-Ph


1849
3-F
2-F—Et
2-(2-thienyl)-Ph


1850
3-F
2-F—Et
2-(2-furanyl)-Ph


1851
3-F
2-F—Et
2,4-diF—Ph


1852
3-F
2-F—Et
2,5-diF—Ph


1853
3-F
2-F—Et
2,6-diF—Ph


1854
3-F
2-F—Et
3,4-diF—Ph


1855
3-F
2-F—Et
3,5-diF—Ph


1856
3-F
2-F—Et
2,4-diCl—Ph


1857
3-F
2-F—Et
2,5-diCl—Ph


1858
3-F
2-F—Et
2,6-diCl—Ph


1859
3-F
2-F—Et
3,4-diCl—Ph


1860
3-F
2-F—Et
3,5-diCl—Ph


1861
3-F
2-F—Et
3,4-diCF3—Ph


1862
3-F
2-F—Et
3,5-diCF3—Ph


1863
3-F
2-F—Et
5-Cl-2-MeO—Ph


1864
3-F
2-F—Et
5-Cl-2-Me—Ph


1865
3-F
2-F—Et
2-F-5-Me—Ph


1866
3-F
2-F—Et
3-F-5-morpholino-Ph


1867
3-F
2-F—Et
3,4-OCH2O—Ph


1868
3-F
2-F—Et
3,4-OCH2CH2O—Ph


1869
3-F
2-F—Et
2-MeO-5-CONH2—Ph


1870
3-F
2-F—Et
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


1871
3-F
2-F—Et
2-MeO-5-(1-Me-5-tetrazolyl)-Ph


1872
3-F
2-F—Et
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


1873
3-F
2-F—Et
1-naphthyl


1874
3-F
2-F—Et
2-naphthyl


1875
3-F
2-F—Et
2-thienyl


1876
3-F
2-F—Et
3-thienyl


1877
3-F
2-F—Et
2-furanyl


1878
3-F
2-F—Et
3-furanyl


1879
3-F
2-F—Et
2-pyridyl


1880
3-F
2-F—Et
3-pyridyl


1881
3-F
2-F—Et
4-pyridyl


1882
3-F
2-F—Et
2-indolyl


1883
3-F
2-F—Et
3-indolyl


1884
3-F
2-F—Et
5-indolyl


1885
3-F
2-F—Et
6-indolyl


1886
3-F
2-F—Et
3-indazolyl


1887
3-F
2-F—Et
5-indazolyl


1888
3-F
2-F—Et
6-indazolyl


1889
3-F
2-F—Et
2-imidazolyl


1890
3-F
2-F—Et
3-isoxazoyl


1891
3-F
2-F—Et
3-pyrazolyl


1892
3-F
2-F—Et
2-thiadiazolyl


1893
3-F
2-F—Et
2-thiazolyl


1894
3-F
2-F—Et
5-Ac-4-Me-2-thiazolyl


1895
3-F
2-F—Et
5-tetrazolyl


1896
3-F
2-F—Et
2-benzimidazolyl


1897
3-F
2-F—Et
5-benzimidazolyl


1898
3-F
2-F—Et
2-benzothiazolyl


1899
3-F
2-F—Et
5-benzothiazolyl


1900
3-F
2-F—Et
2-benzoxazolyl


1901
3-F
2-F—Et
5-benzoxazolyl


1902
3-F
2-F—Et
1-adamantyl


1903
3-F
2-F—Et
2-adamantyl


1904
3-F
2-F—Et
i-Pr


1905
3-F
2-F—Et
t-Bu


1906
3-F
2-F—Et
c-Hex


1907
3-F
2-F—Et
CH2CH2OMe


1908
3-F
2-F—Et
CH2CONH2


1909
3-F
2-F—Et
CH2CO2Me


1910
3-F
2-F—Et
CH(CH2Ph)CO2Me


1911
3-F
2-F—Et
CH2CH2NMe2


1912
3-F
2-F—Et
benzyl


1913
3-F
2-F—Et
phenethyl


1914
3-F
2-F—Et
2-(morpholin-1-yl)-Et


1915
3-F
CO2Me
Ph


1916
3-F
CO2Me
3-CN—Ph


1917
3-F
CO2Me
3-COMe—Ph


1918
3-F
CO2Me
3-CO2Me—Ph


1919
3-F
CO2Me
3-CONH2—Ph


1920
3-F
CO2Me
3-CONHMe—Ph


1921
3-F
CO2Me
3-F—Ph


1922
3-F
CO2Me
3-Cl—Ph


1923
3-F
CO2Me
3-Br—Ph


1924
3-F
CO2Me
3-SO2NH2—Ph


1925
3-F
CO2Me
3-SO2NHMe—Ph


1926
3-F
CO2Me
3-CF3—Ph


1927
3-F
CO2Me
3-OMe—Ph


1928
3-F
CO2Me
3-SMe—Ph


1929
3-F
CO2Me
3-SOMe—Ph


1930
3-F
CO2Me
3-SO2Me—Ph


1931
3-F
CO2Me
3-OH—Ph


1932
3-F
CO2Me
3-CH2OH—Ph


1934
3-F
CO2Me
3-COH(Me)2—Ph


1935
3-F
CO2Me
3-Me—Ph


1936
3-F
CO2Me
3-Et—Ph


1937
3-F
CO2Me
3-iPr—Ph


1938
3-F
CO2Me
3-tBu—Ph


1939
3-F
CO2Me
3-CH2CO2Me—Ph


1940
3-F
CO2Me
3-(1-piperidinyl)-Ph


1941
3-F
CO2Me
3-(1-pyrrolidinyl)-Ph


1942
3-F
CO2Me
3-(2-imidazolyl)-Ph


1943
3-F
CO2Me
3-(1-imidazolyl)-Ph


1944
3-F
CO2Me
3-(2-thiazolyl)-Ph


1945
3-F
CO2Me
3-(3-pyrazolyl)-Ph


1946
3-F
CO2Me
3-(1-pyrazolyl)-Ph


1947
3-F
CO2Me
3-(5-Me-1-tetrazolyl)-Ph


1948
3-F
CO2Me
3-(1-Me-5-tetrazolyl)-Ph


1949
3-F
CO2Me
3-(2-pyridyl)-Ph


1950
3-F
CO2Me
3-(2-thienyl)-Ph


1951
3-F
CO2Me
3-(2-furanyl)-Ph


1952
3-F
CO2Me
4-CN—Ph


1953
3-F
CO2Me
4-COMe—Ph


1954
3-F
CO2Me
4-CO2Me—Ph


1955
3-F
CO2Me
4-CONH2—Ph


1956
3-F
CO2Me
4-CONHMe—Ph


1957
3-F
CO2Me
4-CONHPh—Ph


1958
3-F
CO2Me
4-F—Ph


1959
3-F
CO2Me
4-Cl—Ph


1960
3-F
CO2Me
4-Br—Ph


1961
3-F
CO2Me
4-SO2NH2—Ph


1962
3-F
CO2Me
4-SO2NHMe—Ph


1963
3-F
CO2Me
4-CF3—Ph


1964
3-F
CO2Me
4-OMe—Ph


1965
3-F
CO2Me
4-SMe—Ph


1966
3-F
CO2Me
4-SOMe—Ph


1967
3-F
CO2Me
4-SO2Me—Ph


1968
3-F
CO2Me
4-OH—Ph


1969
3-F
CO2Me
4-CH2OH—Ph


1970
3-F
CO2Me
4-CHOHMe—Ph


1971
3-F
CO2Me
4-COH(Me)2—Ph


1972
3-F
CO2Me
4-Me—Ph


1973
3-F
CO2Me
4-Et—Ph


1974
3-F
CO2Me
4-iPr—Ph


1975
3-F
CO2Me
4-tBu—Ph


1976
3-F
CO2Me
4-CH2CO2Me—Ph


1977
3-F
CO2Me
4-(1-piperidinyl)-Ph


1978
3-F
CO2Me
4-(1-pyrrolidinyl)-Ph


1979
3-F
CO2Me
4-(2-imidazolyl)-Ph


1980
3-F
CO2Me
4-(1-imidazolyl)-Ph


1981
3-F
CO2Me
4-(2-thiazolyl)-Ph


1982
3-F
CO2Me
4-(3-pyrazolyl)-Ph


1983
3-F
CO2Me
4-(1-pyrazolyl)-Ph


1984
3-F
CO2Me
4-(5-Me-1-tetrazolyl)-Ph


1985
3-F
CO2Me
4-(1-Me-5-tetrazolyl)-Ph


1986
3-F
CO2Me
4-(2-pyridyl)-Ph


1987
3-F
CO2Me
4-(2-thierayl)-Ph


1988
3-F
CO2Me
4-(2-furanyl)-Ph


1989
3-F
CO2Me
2-CN—Ph


1990
3-F
CO2Me
2-COMe—Ph


1991
3-F
CO2Me
2-CO2Me—Ph


1992
3-F
CO2Me
2-CONH2—Ph


1993
3-F
CO2Me
2-CONHMe—Ph


1994
3-F
CO2Me
2-F—Ph


1995
3-F
CO2Me
2-Cl—Ph


1996
3-F
CO2Me
2-Br—Ph


1997
3-F
CO2Me
2-SO2NH2—Ph


1998
3-F
CO2Me
2-SO2NHMe—Ph


1999
3-F
CO2Me
2-CF3—Ph


2000
3-F
CO2Me
2-OMe—Ph


2001
3-F
CO2Me
2-SMe—Ph


2002
3-F
CO2Me
2-SOMe—Ph


2003
3-F
CO2Me
2-SO2Me—Ph


2004
3-F
CO2Me
2-OH—Ph


2005
3-F
CO2Me
2-CH2OH—Ph


2006
3-F
CO2Me
2-CHOHMe—Ph


2007
3-F
CO2Me
2-COH(Me)2—Ph


2008
3-F
CO2Me
2-Me—Ph


2009
3-F
CO2Me
2-Et—Ph


2010
3-F
CO2Me
2-iPr—Ph


2011
3-F
CO2Me
2-tBu—Ph


2012
3-F
CO2Me
2-CH2CO2Me—Ph


2013
3-F
CO2Me
2-(1-piperidinyl)-Ph


2014
3-F
CO2Me
2-(1-pyrrolidinyl)-Ph


2015
3-F
CO2Me
2-(2-imidazolyl)-Ph


2016
3-F
CO2Me
2-(1-imidazolyl)-Ph


2017
3-F
CO2Me
2-(2-thiazolyl)-Ph


2018
3-F
CO2Me
2-(3-pyrazolyl)-Ph


2019
3-F
CO2Me
2-(1-pyrazolyl)-Ph


2020
3-F
CO2Me
2-(5-Me-1-tetrazolyl)-Ph


2021
3-F
CO2Me
2-(1-Me-5-tetrazolyl)-Ph


2022
3-F
CO2Me
2-(2-pyridyl)-Ph


2023
3-F
CO2Me
2-(2-thienyl)-Ph


2024
3-F
CO2Me
2-(2-furanyl)-Ph


2025
3-F
CO2Me
2,4-diF—Ph


2026
3-F
CO2Me
2,5-diF—Ph


2027
3-F
CO2Me
2,6-diF—Ph


2028
3-F
CO2Me
3,4-diF—Ph


2029
3-F
CO2Me
3,5-diF—Ph


2030
3-F
CO2Me
2,4-diCl—Ph


2031
3-F
CO2Me
2,5-diCl—Ph


2032
3-F
CO2Me
2,6-diCl—Ph


2033
3-F
CO2Me
3,4-diCl—Ph


2034
3-F
CO2Me
3,5-diCl—Ph


2035
3-F
CO2Me
3,4-diCF3—Ph


2036
3-F
CO2Me
3,5-diCF3—Ph


2037
3-F
CO2Me
5-Cl-2-MeO—Ph


2038
3-F
CO2Me
5-Cl-2-Me—Ph


2039
3-F
CO2Me
2-F-5-Me—Ph


2040
3-F
CO2Me
3-F-5-morpholino-Ph


2041
3-F
CO2Me
3,4-OCH2O—Ph


2042
3-F
CO2Me
3,4-OCH2CH2O—Ph


2043
3-F
CO2Me
2-MeO-5-CONH2—Ph


2044
3-F
CO2Me
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


2045
3-F
CO2Me
2-MeO-5-(1-Me-5-tetrazolyl)-Ph


2046
3-F
CO2Me
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


2053
3-F
CO2Me
2-pyridyl


2054
3-F
CO2Me
3-pyridyl


2055
3-F
CO2Me
4-pyridyl


2056
3-F
CO2Me
2-indolyl


2057
3-F
CO2Me
3-indolyl


2058
3-F
CO2Me
5-indolyl


2059
3-F
CO2Me
6-indolyl


2060
3-F
CO2Me
3-indazolyl


2061
3-F
CO2Me
5-indazolyl


2062
3-F
CO2Me
6-indazolyl


2063
3-F
CO2Me
2-imidazolyl


2064
3-F
CO2Me
3-isoxazoyl


2065
3-F
CO2Me
3-pyrazolyl


2066
3-F
CO2Me
2-thiadiazolyl


2067
3-F
CO2Me
2-thiazolyl


2068
3-F
CO2Me
5-Ac-4-Me-2-thiazolyl


2069
3-F
CO2Me
5-tetrazolyl


2070
3-F
CO2Me
2-benzimidazolyl


2071
3-F
CO2Me
5-benzimidazolyl


2072
3-F
CO2Me
2-benzothiazolyl


2073
3-F
CO2Me
5-benzothiazolyl


2074
3-F
CO2Me
2-benzoxazolyl


2075
3-F
CO2Me
5-benzoxazolyl


2076
3-F
CO2Me
1-adamantyl


2077
3-F
CO2Me
2-adamantyl


2078
3-F
CO2Me
i-Pr


2079
3-F
CO2Me
t-Bu


2080
3-F
CO2Me
c-Hex


2081
3-F
CO2Ne
CH2CH2OMe


2082
3-F
CO2Me
CH2CONH2


2083
3-F
CO2Me
CH2CO2Me


2084
3-F
CO2Me
CH(CH2Ph)CO2Me


2085
3-F
CO2Me
CH2CH2NMe2


2086
3-F
CO2Me
benzyl


2087
3-F
CO2Me
phenethyl


2088
3-F
CO2Me
2-(morpholin-1-yl)-Et


2089
3-F
Ac
Ph


2090
3-F
Ac
3-CN—Ph


2091
3-F
Ac
3-COMe—Ph


2092
3-F
Ac
3-CO2Me—Ph


2093
3-F
Ac
3-CONH2—Ph


2094
3-F
Ac
3-CONHMe—Ph


2095
3-F
Ac
3-F—Ph


2096
3-F
Ac
3-Cl—Ph


2097
3-F
Ac
3-Br—Ph


2098
3-F
Ac
3-SO2NH2—Ph


2099
3-F
Ac
3-SO2NHMe—Ph


2100
3-F
Ac
3-CF3—Ph


2101
3-F
Ac
3-OMe—Ph


2102
3-F
Ac
3-SMe—Ph


2103
3-F
Ac
3-SOMe—Ph


2104
3-F
Ac
3-SO2Me—Ph


2105
3-F
Ac
3-OH—Ph


2106
3-F
Ac
3-CH2OH—Ph


2107
3-F
Ac
3-CHOHMe—Ph


2108
3-F
Ac
3-COH(Me)2—Ph


2109
3-F
Ac
3-Me—Ph


2110
3-F
Ac
3-Et—Ph


2111
3-F
Ac
3-iPr—Ph


2112
3-F
Ac
3-tBu—Ph


2113
3-F
Ac
3-CH2CO2Me—Ph


2114
3-F
Ac
3-(1-piperidinyl)-Ph


2115
3-F
Ac
3-(pyrrolidinyl)-Ph


2116
3-F
Ac
3-(2-imidazolyl)-Ph


2117
3-F
Ac
3-(1-imidazolyl)-Ph


2118
3-F
Ac
3-(2-thiazolyl)-Ph


2119
3-F
Ac
3-(3-pyrazolyl)-Ph


2120
3-F
Ac
3-(1-pyrazolyl)-Ph


2121
3-F
Ac
3-(5-Me-1-tetrazolyl)-Ph


2122
3-F
Ac
3-(1-Me-5-tetrazolyl)-Ph


2123
3-F
Ac
3-(2-pyridyl)-Ph


2124
3-F
Ac
3-(2-thienyl)-Ph


2125
3-F
Ac
3-(2-furanyl)-Ph


2126
3-F
Ac
4-CN—Ph


2127
3-F
Ac
4-COMe—Ph


2128
3-F
Ac
4-CO2Me—Ph


2129
3-F
Ac
4-CONH2—Ph


2130
3-F
Ac
4-CONHMe—Ph


2131
3-F
Ac
4-CONHPh—Ph


2132
3-F
Ac
4-F—Ph


2133
3-F
Ac
4-Cl—Ph


2134
3-F
Ac
4-Br—Ph


2135
3-F
Ac
4-SO2NH2—Ph


2136
3-F
Ac
4-SO2NHMe—Ph


2137
3-F
Ac
4-CF3—Ph


2138
3-F
Ac
4-OMe—Ph


2139
3-F
Ac
4-SMe—Ph


2140
3-F
Ac
4-SOMe—Ph


2141
3-F
Ac
4-SO2Me—Ph


2142
3-F
Ac
4-OH—Ph


2143
3-F
Ac
4-CH2OH—Ph


2144
3-F
Ac
4-CHOHMe—Ph


2145
3-F
Ac
4-COH(Me)2—Ph


2146
3-F
Ac
4-Me—Ph


2147
3-F
Ac
4-Et—Ph


2148
3-F
Ac
4-iPr—Ph


2149
3-F
Ac
4-tBu—Ph


2150
3-F
Ac
4-CH2CO2Me—Ph


2151
3-F
Ac
4-(1-piperidinyl)-Ph


2152
3-F
Ac
4-(1-pyrrolidinyl)-Ph


2153
3-F
Ac
4-(2-imidazolyl)-Ph


2154
3-F
Ac
4-(1-imidazolyl)-Ph


2155
3-F
Ac
4-(2-thiazolyl)-Ph


2156
3-F
Ac
4-(3-pyrazolyl)-Ph


2157
3-F
Ac
4-(1-pyrazolyl)-Ph


2158
3-F
Ac
4-(5-Me-1-tetrazolyl)-Ph


2159
3-F
Ac
4-(1-Me-5-tetrazolyl)-Ph


2160
3-F
Ac
4-(2-pyridyl)-Ph


2161
3-F
Ac
4-(2-thienyl)-Ph


2162
3-F
Ac
4-(2-furanyl)-Ph


2163
3-F
Ac
2-CN—Ph


2164
3-F
Ac
2-COMe—Ph


2165
3-F
Ac
2-CO2Me—Ph


2166
3-F
Ac
2-CONH2—Ph


2167
3-F
Ac
2-CONHMe—Ph


2168
3-F
Ac
2-F—Ph


2169
3-F
Ac
2-Cl—Ph


2170
3-F
Ac
2-Br—Ph


2171
3-F
Ac
2-SO2NH2—Ph


2172
3-F
Ac
2-SO2NHMe—Ph


2173
3-F
Ac
2-CF3—Ph


2174
3-F
Ac
2-OMe—Ph


2175
3-F
Ac
2-SMe—Ph


2176
3-F
Ac
2-SOMe—Ph


2177
3-F
Ac
2-SO2Me—Ph


2178
3-F
Ac
2-OH—Ph


2179
3-F
Ac
2-CH2OH—Ph


2180
3-F
Ac
2-CHOHMe—Ph


2181
3-F
Ac
2-COH(Me)2—Ph


2182
3-F
Ac
2-Me—Ph


2183
3-F
Ac
2-Et—Ph


2184
3-F
Ac
2-iPr—Ph


2185
3-F
Ac
2-tBu—Ph


2186
3-F
Ac
2-CH2CO2Me—Ph


2187
3-F
Ac
2-(1-piperidinyl)-Ph


2188
3-F
Ac
2-(1-pyrrolidinyl)-Ph


2189
3-F
Ac
2-(2-imidazolyl)-Ph


2190
3-F
Ac
2-(1-imidazolyl)-Ph


2191
3-F
Ac
2-(2-thiazolyl)-Ph


2192
3-F
Ac
2-(3-pyrazolyl)-Ph


2193
3-F
Ac
2-(1-pyrazolyl)-Ph


2194
3-F
Ac
2-(5-Me-1-tetrazolyl)-Ph


2195
3-F
Ac
2-(1-Me-5-tetrazolyl)-Ph


2196
3-F
Ac
2-(2-pyridyl)-Ph


2197
3-F
Ac
2-(2-thienyl)-Ph


2198
3-F
Ac
2-(2-furanyl)-Ph


2199
3-F
Ac
2,4-diF—Ph


2200
3-F
Ac
2,5-diF—Ph


2201
3-F
Ac
2,6-diF—Ph


2202
3-F
Ac
3,4-diF—Ph


2203
3-F
Ac
3,5-diF—Ph


2204
3-F
Ac
2,4-diCl—Ph


2205
3-F
Ac
2,5-diCl—Ph


2206
3-F
Ac
2,6-diCl—Ph


2207
3-F
Ac
3,4-diCl—Ph


2208
3-F
Ac
3,5-diCl—Ph


2209
3-F
Ac
3,4-diCF3—Ph


2210
3-F
Ac
3,5-diCF3—Ph


2211
3-F
Ac
5-Cl-2-MeO—Ph


2212
3-F
Ac
5-Cl-2-Me—Ph


2213
3-F
Ac
2-F-5-Me—Ph


2214
3-F
Ac
3-F-5-morpholino-Ph


2215
3-F
Ac
3,4-OCH2O—Ph


2216
3-F
Ac
3,4-OCH2CH2O—Ph


2217
3-F
Ac
2-MeO-5-CONH2—Ph


2218
3-F
Ac
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


2219
3-F
Ac
2-MeO-5-(1-Me-5-tetrazolyl)-Ph


2220
3-F
Ac
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


2221
3-F
Ac
1-naphthyl


2222
3-F
Ac
2-naphthyl


2223
3-F
Ac
2-thienyl


2224
3-F
Ac
3-thienyl


2225
3-F
Ac
2-furanyl


2226
3-F
Ac
3-furanyl


2227
3-F
Ac
2-pyridyl


2228
3-F
Ac
3-pyridyl


2229
3-F
Ac
4-pyridyl


2230
3-F
Ac
2-indolyl


2231
3-F
Ac
3-indolyl


2232
3-F
Ac
5-indolyl


2233
3-F
Ac
6-indolyl


2234
3-F
Ac
3-indazolyl


2235
3-F
Ac
5-indazolyl


2236
3-F
Ac
6-indazolyl


2237
3-F
Ac
2-imidazolyl


2238
3-F
Ac
3-isoxazoyl


2239
3-F
Ac
3-pyrazolyl


2240
3-F
Ac
2-thiadiazolyl


2241
3-F
Ac
2-thiazolyl


2242
3-F
Ac
5-Ac-4-Me-2-thiazolyl


2243
3-F
Ac
5-tetrazolyl


2244
3-F
Ac
2-benzimidazolyl


2245
3-F
Ac
5-benzimidazolyl


2246
3-F
Ac
2-benzothiazolyl


2247
3-F
Ac
5-benzothiazolyl


2248
3-F
Ac
2-benzoxazolyl


2249
3-F
Ac
5-benzoxazolyl


2250
3-F
Ac
1-adamantyl


2251
3-F
Ac
2-adamantyl


2252
3-F
Ac
i-Pr


2253
3-F
Ac
t-Bu


2254
3-F
Ac
c-Hex


2255
3-F
Ac
CH2CH2OMe


2256
3-F
Ac
CH2CONH2


2257
3-F
Ac
CH2CO2Me


2258
3-F
Ac
CR(CH2Ph)CO2Me


2259
3-F
Ac
CH2CH2NMe2


2260
3-F
Ac
benzyl


2261
3-F
Ac
phenethyl


2262
3-F
Ac
2-(morpholin-1-yl)-Et


2263
3-F
COtBu
Ph


2264
3-F
COtBu
3-CN—Ph


2265
3-F
COtBu
3-COMe—Ph


2266
3-F
COtBu
3-CO2Me—Ph


2267
3-F
COtBu
3-CONH2—Ph


2268
3-F
COtBu
3-CONHMe—Ph


2269
3-F
COtBu
3-F—Ph


2270
3-F
COtBu
3-Cl—Ph


2271
3-F
COtBu
3-Br—Ph


2272
3-F
COtBu
3-SO2NH2—Ph


2273
3-F
COtBu
3-SO2NHMe—Ph


2274
3-F
COtBu
3-CF3—Ph


2275
3-F
COtBu
3-OMe—Ph


2276
3-F
COtBu
3-SMe—Ph


2277
3-F
COtBu
3-SOMe—Ph


2278
3-F
COtBu
3-SO2Me—Ph


2279
3-F
COtBu
3-OH—Ph


2280
3-F
COtBu
3-CH2OH—Ph


2281
3-F
COtBu
3-CHOHMe—Ph


2282
3-F
COtBu
3-COH(Me)2—Ph


2283
3-F
COtBu
3-Me—Ph


2284
3-F
COtBu
3-Et—Ph


2285
3-F
COtBu
3-iPr—Ph


2286
3-F
COtBu
3-tBu—Ph


2287
3-F
COtBu
3-CH2CO2Me—Ph


2288
3-F
COtBu
3-(1-piperidinyl)-Ph


2289
3-F
COtBu
3-(1-pyrrolidinyl)-Ph


2290
3-F
COtBu
3-(2-imidazolyl)-Ph


2291
3-F
COtBu
3-(1-imidazolyl)-Ph


2292
3-F
COtBu
3-(2-thiazolyl)-Ph


2293
3-F
COtBu
3-(3-pyrazolyl)-Ph


2294
3-F
COtBu
3-(1-pyrazolyl)-Ph


2295
3-F
COtBu
3-(5-Me-1-tetrazolyl)-Ph


2296
3-F
COtBu
3-(1-Me-5-tetrazolyl)-Ph


2297
3-F
COtBu
3-(2-pyridyl)-Ph


2298
3-F
COtBu
3-(2-thienyl)-Ph


2299
3-F
COtBu
3-(2-furanyl)-Ph


2300
3-F
COtBu
4-CN—Ph


2301
3-F
COtBu
4-COMe—Ph


2302
3-F
COtBu
4-CO2Me—Ph


2303
3-F
COtBu
4-CONH2—Ph


2304
3-F
COtBu
4-CONHMe—Ph


2305
3-F
COtBu
4-CONHPh—Ph


2306
3-F
COtBu
4-F—Ph


2307
3-F
COtBu
4-Cl—Ph


2308
3-F
COtBu
4-Br—Ph


2309
3-F
COtBu
4-SO2NH2—Ph


2310
3-F
COtBu
4-SO2NHMe—Ph


2311
3-F
COtBu
4-CF3—Ph


2312
3-F
COtBu
4-OMe—Ph


2313
3-F
COtBu
4-SMe—Ph


2314
3-F
COtBu
4-SOMe—Ph


2315
3-F
COtBu
4-SO2Me—Ph


2316
3-F
COtBu
4-OH—Ph


2317
3-F
COtBu
4-CH2OH—Ph


2318
3-F
COtBu
4-CHOHMe—Ph


2319
3-F
COtBu
4-COH(Me)2—Ph


2320
3-F
COtBu
4-Me—Ph


2321
3-F
COtBu
4-Et—Ph


2322
3-F
COtBu
4-iPr—Ph


2323
3-F
COtBu
4-tBu—Ph


2324
3-F
COtBu
4-CH2CO2Me—Ph


2325
3-F
COtBu
4-(1-piperidinyl)-Ph


2326
3-F
COtBu
4-(1-pyrrolidinyl)-Ph


2327
3-F
COtBu
4-(2-imidazolyl)-Ph


2328
3-F
COtBu
4-(1-imidazolyl)-Ph


2329
3-F
COtBu
4-(2-thiazolyl)-Ph


2330
3-F
COtBu
4-(3-pyrazolyl)-Ph


2331
3-F
COtBu
4-(1-pyrazolyl)-Ph


2332
3-F
COtBu
4-(5-Me-1-tetrazolyl)-Ph


2333
3-F
COtBu
4-(1-Me-5-tetrazolyl)-Ph


2334
3-F
COtBu
4-(2-pyridyl)-Ph


2335
3-F
COtBu
4-(2-thienyl)-Ph


2336
3-F
COtBu
4-(2-furanyl)-Ph


2337
3-F
COtBu
2-CN—Ph


2338
3-F
COtBu
2-COMe—Ph


2339
3-F
COtBu
2-CO2Me—Ph


2340
3-F
COtBu
2-CONH2—Ph


2341
3-F
COtBu
2-CONHNe—Ph


2342
3-F
COtBu
2-F—Ph


2343
3-F
COtBu
2-Cl—Ph


2344
3-F
COtBu
2-Br—Ph


2345
3-F
COtBu
2-SO2NH2—Ph


2346
3-F
COtBu
2-SO2NHMe—Ph


2347
3-F
COtBu
2-CF3—Ph


2348
3-F
COtBu
2-OMe—Ph


2349
3-F
COtBu
2-SMe—Ph


2350
3-F
COtBu
2-SOMe—Ph


2351
3-F
COtBu
2-SO2Me—Ph


2352
3-F
COtBu
2-OH—Ph


2353
3-F
COtBu
2-CH2OH—Ph


2354
3-F
COtBu
2-CHOHMe—Ph


2355
3-F
COtBu
2-COH(Me)2—Ph


2356
3-F
COtBu
2-Me—Ph


2357
3-F
COtBu
2-Et—Ph


2358
3-F
COtBu
2-iPr—Ph


2359
3-F
COtBu
2-tBu—Ph


2360
3-F
COtBu
2-CH2CO2Me—Ph


2361
3-F
COtBu
2-(1-piperidinyl)-Ph


2362
3-F
COtBu
2-(1-pyrrolidinyl)-Ph


2363
3-F
COtBu
2-(2-imidazolyl)-Ph


2364
3-F
COtBu
2-(1-imidazolyl)-Ph


2365
3-F
COtBu
2-(2-thiazolyl)-Ph


2366
3-F
COtBu
2-(3-pyrazolyl)-Ph


2367
3-F
COtBu
2-(1-pyrazolyl)-Ph


2368
3-F
COtBu
2-(5-Me-1-tetrazolyl)-Ph


2369
3-F
COtBu
2-(1-Me-5-tetrazolyl)-Ph


2370
3-F
COtBu
2-(2-pyridyl)-Ph


2371
3-F
COtBu
2-(2-thienyl)-Ph


2372
3-F
COtBu
2-(2-furanyl)-Ph


2373
3-F
COtBu
2,4-diF—Ph


2374
3-F
COtBu
2,5-diF—Ph


2375
3-F
COtBu
2,6-diF—Ph


2376
3-F
COtBu
3,4-diF—Ph


2377
3-F
COtBu
3,5-diF—Ph


2378
3-F
COtBu
2,4-diCl—Ph


2379
3-F
COtBu
2,5-diCl—Ph


2380
3-F
COtBu
2,6-diCl—Ph


2381
3-F
COtBu
3,4-diCl—Ph


2382
3-F
COtBu
3,5-diCl—Ph


2383
3-F
COtBu
3,4-diCF3—Ph


2384
3-F
COtBu
3,5-diCF3—Ph


2385
3-F
COtBu
5-Cl-2-MeO—Ph


2386
3-F
COtBu
5-Cl-2-Me—Ph


2387
3-F
COtBu
2-F-5-Me—Ph


2388
3-F
COtBu
3-F-5-morpholino-Ph


2389
3-F
COtBu
3,4-OCH2O—Ph


2390
3-F
COtBu
3,4-OCH2CH2O—Ph


2391
3-F
COtBu
2-MeO-5-CONH2—Ph


2392
3-F
COtBu
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


2393
3-F
COtBu
2-MeO-5-(1-Me-5-tetrazolyl)-Ph


2394
3-F
COtBu
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


2395
3-F
COtBu
1-naphthyl


2396
3-F
COtBu
2-naphthyl


2397
3-F
COtBu
2-thienyl


2398
3-F
COtBu
3-thienyl


2399
3-F
COtBu
2-furanyl


2400
3-F
COtBu
3-furanyl


2401
3-F
COtBu
2-pyridyl


2402
3-F
COtBu
3-pyridyl


2403
3-F
COtBu
4-pyridyl


2404
3-F
COtBu
2-indolyl


2405
3-F
COtBu
3-indolyl


2406
3-F
COtBu
5-indolyl


2407
3-F
COtBu
6-indolyl


2408
3-F
COtBu
3-indazolyl


2409
3-F
COtBu
5-indazolyl


2410
3-F
COtBu
6-indazolyl


2411
3-F
COtBu
2-imidazolyl


2412
3-F
COtBu
3-isoxazoyl


2413
3-F
COtBu
3-pyrazolyl


2414
3-F
COtBu
2-thiadiazolyl


2415
3-F
COtBu
2-thiazolyl


2416
3-F
COtBu
5-Ac-4-Me-2-thiazolyl


2417
3-F
COtBu
5-tetrazolyl


2418
3-F
COtBu
2-benzimidazolyl


2419
3-F
COtBu
5-benzimidazolyl


2420
3-F
COtBu
2-benzothiazolyl


2421
3-F
COtBu
5-benzothiazolyl


2422
3-F
COtBu
2-benzoxazolyl


2423
3-F
COtBu
5-benzoxazolyl


2424
3-F
COtBu
1-adamantyl


2425
3-F
COtBu
2-adamantyl


2426
3-F
COtBu
i-Pr


2427
3-F
COtBu
t-Bu


2428
3-F
COtBu
c-Hex


2429
3-F
COtBu
CH2CH2OMe


2430
3-F
COtBu
CH2CONH2


2431
3-F
COtBu
CH2CO2Me


2432
3-F
COtBu
CH(CH2Ph)CO2Me


2433
3-F
COtBu
CH2CH2NMe2


2434
3-F
COtBu
benzyl


2435
3-F
COtBu
phenethyl


2436
3-F
COtBu
2-(morpholin-1-yl)-Et


2437
3-F
SO2Me
Ph


2438
3-F
SO2Me
3-CN—Ph


2439
3-F
SO2Me
3-COMe—Ph


2440
3-F
SO2Me
3-CO2Me—Ph


2441
3-F
SO2Me
3-CONH2—Ph


2442
3-F
SO2Me
3-CONHMe—Ph


2443
3-F
SO2Me
3-F—Ph


2444
3-F
SO2Me
3-Cl—Ph


2445
3-F
SO2Me
3-Br—Ph


2446
3-F
SO2Me
3-SO2NH2—Ph


2447
3-F
SO2Me
3-SO2NHMe—Ph


2448
3-F
SO2Me
3-CF3—Ph


2449
3-F
SO2Me
3-OMe—Ph


2450
3-F
SO2Me
3-SMe—Ph


2451
3-F
SO2Me
3-SOMe—Ph


2452
3-F
SO2Me
3-SO2Me—Ph


2453
3-F
SO2Me
3-OH—Ph


2454
3-F
SO2Me
3-CH2OH—Ph


2455
3-F
SO2Me
3-CHOHMe—Ph


2456
3-F
SO2Me
3-COH(Me)2—Ph


2457
3-F
SO2Me
3-Me—Ph


2458
3-F
SO2Me
3-Et—Ph


2459
3-F
SO2Me
3-ipr—Ph


2460
3-F
SO2Me
3-tBu—Ph


2461
3-F
SO2Me
3-CH2CO2Me—Ph


2462
3-F
SO2Me
3-(1-piperidinyl)-Ph


2463
3-F
SO2Me
3-(1-pyrrolidinyl)-Ph


2464
3-F
SO2Me
3-(2-iniidazolyl)-Ph


2465
3-F
SO2Me
3-(1-imidazolyl)-Ph


2466
3-F
SO2Me
3-(2-thiazolyl)-Ph


2467
3-F
SO2Me
3-(3-pyrazolyl)-Ph


2468
3-F
SO2Me
3-(1-pyrazolyl)-Ph


2469
3-F
SO2Me
3-(5-Me-1-tetrazolyl)-Ph


2470
3-F
SO2Me
3-(1-Me-5-tetrazolyl)-Ph


2471
3-F
SO2Me
3-(2-pyridyl)-Ph


2472
3-F
SO2Me
3-(2-thienyl)-Ph


2473
3-F
SO2Me
3-(2-furanyl)-Ph


2474
3-F
SO2Me
4-CN—Ph


2475
3-F
SO2Me
4-COMe—Ph


2476
3-F
SO2Me
4-CO2Me—Ph


2477
3-F
SO2Me
4-CONH2—Ph


2478
3-F
SO2Me
4-CONHMe—Ph


2479
3-F
SO2Me
4-CONHPh—Ph


2480
3-F
SO2Me
4-F—Ph


2481
3-F
SO2Me
4-Cl—Ph


2482
3-F
SO2Me
4-Br—Ph


2483
3-F
SO2Me
4-SO2NH2—Ph


2484
3-F
SO2Me
4-SO2NHMe—Ph


2485
3-F
SO2Me
4-CF3—Ph


2486
3-F
SO2Me
4-OMe—Ph


2487
3-F
SO2Me
4-SMe—Ph


2488
3-F
SO2Me
4-SOMe—Ph


2489
3-F
SO2Me
4-SO2Me—Ph


2490
3-F
SO2Me
4-OH—Ph


2491
3-F
SO2Me
4-CH2OH—Ph


2492
3-F
SO2Me
4-CHOHMe—Ph


2493
3-F
SO2Me
4-COH(Me)2—Ph


2494
3-F
SO2Me
4-Me—Ph


2495
3-F
SO2Me
4-Et—Ph


2496
3-F
SO2Me
4-iPr—Ph


2497
3-F
SO2Me
4-tBu—Ph


2498
3-F
SO2Me
4-CH2CO2Me—Ph


2499
3-F
SO2Me
4-(1-piperidinyl)-Ph


2500
3-F
SO2Me
4-(1-pyrrolidinyl)-Ph


2501
3-F
SO2Me
4-(2-imidazolyl)-Ph


2502
3-F
SO2Me
4-(1-imidazolyl)-Ph


2503
3-F
SO2Me
4-(2-thiazolyl)-Ph


2504
3-F
SO2Me
4-(3-pyrazolyl)-Ph


2505
3-F
SO2Me
4-(1-pyrazolyl)-Ph


2506
3-F
SO2Me
4-(5-Me-1-tetrazolyl)-Ph


2507
3-F
SO2Me
4-(1-Me-5-tetrazalyl)-Ph


2508
3-F
SO2Me
4-(2-pyridyl)-Ph


2509
3-F
SO2Me
4-(2-thienyl)-Ph


2510
3-F
SO2Me
4-(2-furanyl)-Ph


2511
3-F
SO2Me
2-CN—Ph


2512
3-F
SO2Me
2-COMe—Ph


2513
3-F
SO2Me
2-CO2Me—Ph


2514
3-F
SO2Me
2-CONH2—Ph


2515
3-F
SO2Me
2-CONHMe—Ph


2516
3-F
SO2Me
2-F—Ph


2517
3-F
SO2Me
2-Cl—Ph


2518
3-F
SO2Me
2-Br—Ph


2519
3-F
SO2Me
2-SO2NH2—Ph


2520
3-F
SO2Me
2-SO2NHMe—Ph


2521
3-F
SO2Me
2-CF3—Ph


2522
3-F
SO2Me
2-OMe—Ph


2523
3-F
SO2Me
2-SMe—Ph


2524
3-F
SO2Me
2-SOMe—Ph


2525
3-F
SO2Me
2-SO2Me—Ph


2526
3-F
SO2Me
2-OH—Ph


2527
3-F
SO2Me
2-CH2OH—Ph


2528
3-F
SO2Me
2-CHOHMe—Ph


2529
3-F
SO2Me
2-COH(Me)2—Ph


2530
3-F
SO2Me
2-Me—Ph


2531
3-F
SO2Me
2-Et—Ph


2532
3-F
SO2Me
2-iPr—Ph


2533
3-F
SO2Me
2-tBu—Ph


2534
3-F
SO2Me
2-CH2CO2Me—Ph


2535
3-F
SO2Me
2-(1-piperidinyl)-Ph


2536
3-F
SO2Me
2-(1-pyrrolidinyl)-Ph


2537
3-F
SO2Me
2-(2-imidazolyl)-Ph


2538
3-F
SO2Me
2-(1-imidazolyl)-Ph


2539
3-F
SO2Me
2-(2-thiazolyl)-Ph


2540
3-F
SO2Me
2-(3-pyrazolyl)-Ph


2541
3-F
SO2Me
2-(1-pyrazolyl)-Ph


2542
3-F
SO2Me
2-(5-Me-1-tetrazolyl)-Ph


2543
3-F
SO2Me
2-(1-Me-5-tetrazolyl)-Ph


2544
3-F
SO2Me
2-(2-pyridyl)-Ph


2545
3-F
SO2Me
2-(2-thienyl)-Ph


2546
3-F
SO2Me
2-(2-furanyl)-Ph


2547
3-F
SO2Me
2,4-diF—Ph


2548
3-F
SO2Me
2,5-diF—Ph


2549
3-F
SO2Me
2,6-diF—Ph


2550
3-F
SO2Me
3,4-diF—Ph


2551
3-F
SO2Me
3,5-diF—Ph


2552
3-F
SO2Me
2,4-diCl—Ph


2553
3-F
SO2Me
2,5-diCl—Ph


2554
3-F
SO2Me
2,6-diCl—Ph


2555
3-F
SO2Me
3,4-diCl—Ph


2556
3-F
SO2Me
3,5-diCl—Ph


2557
3-F
SO2Me
3,4-diCF3—Ph


2558
3-F
SO2Me
3,5-diCF3—Ph


2559
3-F
SO2Me
5-Cl-2-MeO—Ph


2560
3-F
SO2Me
5-Cl-2-Me—Ph


2561
3-F
SO2Me
2-F-5-Me—Ph


2562
3-F
SO2Me
3-F-5-morpholino-Ph


2563
3-F
SO2Me
3,4-OCH2O—Ph


2564
3-F
SO2Me
3,4-OCH2CH2O—Ph


2565
3-F
SO2Me
2-MeO-5-CONH2—Ph


2566
3-F
SO2Me
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


2567
3-F
SO2Me
2-MeO-5-(1-Me-5-tetrazolyl)-Ph


2568
3-F
SO2Me
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


2569
3-F
SO2Me
1-naphthyl


2570
3-F
SO2Me
2-naphthyl


2571
3-F
SO2Me
2-thienyl


2572
3-F
SO2Me
3-thienyl


2573
3-F
SO2Me
2-furanyl


2574
3-F
SO2Me
3-furanyl


2575
3-F
SO2Me
2-pyridyl


2576
3-F
SO2Me
3-pyridyl


2577
3-F
SO2Me
4-pyridyl


2578
3-F
SO2Me
2-indolyl


2579
3-F
SO2Me
3-indolyl


2580
3-F
SO2Me
5-indolyl


2581
3-F
SO2Me
6-indolyl


2582
3-F
SO2Me
3-indazolyl


2583
3-F
SO2Me
5-indazolyl


2584
3-F
SO2Me
6-indazolyl


2585
3-F
SO2Me
2-imidazolyl


2586
3-F
SO2Me
3-isoxazoyl


2587
3-F
SO2Me
3-pyrazolyl


2588
3-F
SO2Me
2-thiadiazolyl


2589
3-F
SO2Me
2-thiazolyl


2590
3-F
SO2Me
5-Ac-4-Me-2-thiazolyl


2591
3-F
SO2Me
5-tetrazolyl


2592
3-F
SO2Me
2-benzimidazolyl


2593
3-F
SO2Me
5-benzimidazolyl


2594
3-F
SO2Me
2-benzothiazolyl


2595
3-F
SO2Me
5-benzothiazolyl


2596
3-F
SO2Me
2-benzoxazolyl


2597
3-F
SO2Me
5-benzoxazolyl


2598
3-F
SO2Me
1-adamantyl


2599
3-F
SO2Me
2-adarnantyl


2600
3-F
SO2Me
i-Pr


2601
3-F
SO2Me
t-Bu


2602
3-F
SO2Me
c-Hex


2603
3-F
SO2Me
CH2CH2OMe


2604
3-F
SO2Me
CH2CONH2


2605
3-F
SO2Me
CH2CO2Me


2606
3-F
SO2Me
CH(CH2Ph)CO2Me


2607
3-F
SO2Me
CH2CH2NMe2


2608
3-F
SO2Me
benzyl


2609
3-F
SO2Me
phenethyl


2610
3-F
SO2Me
2-(morpholin-1-yl)-Et


2611
3-F
CH2COMe
Ph


2612
3-F
CH2COMe
3-CN—Ph


2613
3-F
CH2COMe
3-COMe—Ph


2614
3-F
CH2COMe
3-CO2Me—Ph


2615
3-F
CH2COMe
3-CONH2—Ph


2616
3-F
CH2COMe
3-CONHMe—Ph


2617
3-F
CH2COMe
3-F—Ph


2618
3-F
CH2COMe
3-Cl—Ph


2619
3-F
CH2COMe
3-Br—Ph


2620
3-F
CH2COMe
3-SO2NH2—Ph


2621
3-F
CH2COMe
3-SO2NHMe—Ph


2622
3-F
CH2COMe
3-CF3—Ph


2623
3-F
CH2COMe
3-OMe—Ph


2624
3-F
CH2COMe
3-SMe—Ph


2625
3-F
CH2COMe
3-SOMe—Ph


2626
3-F
CH2COMe
3-SO2Me—Ph


2627
3-F
CH2COMe
3-OH—Ph


2628
3-F
CH2COMe
3-CH2OH—Ph


2629
3-F
CH2COMe
3-CHOHMe—Ph


2630
3-F
CH2COMe
3-COH(Me)2—Ph


2631
3-F
CH2COMe
3-Me—Ph


2632
3-F
CH2COMe
3-Et—Ph


2633
3-F
CH2COMe
3-iPr—Ph


2634
3-F
CH2COMe
3-tBu—Ph


2635
3-F
CH2COMe
3-CH2CO2Me—Ph


2636
3-F
CH2COMe
3-(1-piperidinyl)-Ph


2637
3-F
CH2COMe
3-(1-pyrrolidinyl)-Ph


2638
3-F
CH2COMe
3-(2-imidazolyl)-Ph


2639
3-F
CH2COMe
3-(1-imidazolyl)-Ph


2640
3-F
CH2COMe
3-(2-thiazolyl)-Ph


2641
3-F
CH2COMe
3-(3-pyrazolyl)-Ph


2642
3-F
CH2COMe
3-(1-pyrazolyl)-Ph


2643
3-F
CH2COMe
3-(5-Me-1-tetrazolyl)-Ph


2644
3-F
CH2COMe
3-(1-Me-5-tetrazolyl)-Ph


2645
3-F
CH2COMe
3-(2-pyridyl)-Ph


2646
3-F
CH2COMe
3-(2-thienyl)-Ph


2647
3-F
CH2COMe
3-(2-furanyl)-Ph


2648
3-F
CH2COMe
4-CN—Ph


2649
3-F
CH2COMe
4-COMe—Ph


2650
3-F
CH2COMe
4-CO2Me—Ph


2651
3-F
CH2COMe
4-CONH2—Ph


2652
3-F
CH2COMe
4-CONHMe—Ph


2653
3-F
CH2COMe
4-CONHPh—Ph


2654
3-F
CH2COMe
4-F—Ph


2655
3-F
CH2COMe
4-Cl—Ph


2656
3-F
CH2COMe
4-Br—Ph


2657
3-F
CH2COMe
4-SO2NH2—Ph


2658
3-F
CH2COMe
4-SO2NHMe—Ph


2659
3-F
CH2COMe
4-CF3—Ph


2660
3-F
CH2COMe
4-OMe—Ph


2661
3-F
CH2COMe
4-SMe—Ph


2662
3-F
CH2COMe
4-SOMe—Ph


2663
3-F
CH2COMe
4-SO2Me—Ph


2664
3-F
CH2COMe
4-OH—Ph


2665
3-F
CH2COMe
4-CH2OH—Ph


2666
3-F
CH2COMe
4-CHOHMe—Ph


2667
3-F
CH2COMe
4-COH(Me)2—Ph


2668
3-F
CH2CONe
4-Me—Ph


2669
3-F
CH2COMe
4-Et—Ph


2670
3-F
CH2COMe
4-iPr—Ph


2671
3-F
CH2COMe
4-tBu—Ph


2672
3-F
CH2COMe
4-CH2CO2Me—Ph


2673
3-F
CH2COMe
4-(1-piperidinyl)-Ph


2674
3-F
CH2COMe
4-(1-rrolidinyl)-Ph


2675
3-F
CH2COMe
4-(2-imidazolyl)-Ph


2676
3-F
CH2COMe
4-(1-imidazolyl)-Ph


2677
3-F
CH2COMe
4-(2-thiazolyl)-Ph


2678
3-F
CH2COMe
4-(3-pyrazolyl)-Ph


2679
3-F
CH2COMe
4-(1-pyrazolyl)-Ph


2680
3-F
CH2COMe
4-(5-Me-1-tetrazolyl)-Ph


2681
3-F
CH2COMe
4-(1-Me-5-tetrazolyl)-Ph


2682
3-F
CH2COMe
4-(2-pyridyl)-Ph


2683
3-F
CH2CONe
4-(2-thienyl)-Ph


2684
3-F
CH2COMe
4-(2-furanyl)-Ph


2685
3-F
CH2COMe
2-CN—Ph


2686
3-F
CH2COMe
2-COMe—Ph


2687
3-F
CH2COMe
2-CO2Me—Ph


2688
3-F
CH2CONe
2-CONH2—Ph


2689
3-F
CH2CONe
2-CONHMe—Ph


2690
3-F
CH2COMe
2-F—Ph


2691
3-F
CH2COMe
2-Cl—Ph


2692
3-F
CH2COMe
2-Br—Ph


2693
3-F
CH2CONe
2-SO2NH2—Ph


2694
3-F
CH2COMe
2-SO2NHMe—Ph


2695
3-F
CH2COMe
2-CF3—Ph


2696
3-F
CH2COMe
2-OMe—Ph


2697
3-F
CH2COMe
2-SMe—Ph


2698
3-F
CH2COMe
2-SOMe—Ph


2699
3-F
CH2COMe
2-SO2Me—Ph


2700
3-F
CH2COMe
2-OH—Ph


2701
3-F
CH2COMe
2-CH2OH—Ph


2702
3-F
CH2COMe
2-CHOHMe—Ph


2703
3-F
CH2COMe
2-COH(Me)2—Ph


2704
3-F
CH2COMe
2-Me—Ph


2705
3-F
CH2COMe
2-Et—Ph


2706
3-F
CH2COMe
2-iPr—Ph


2707
3-F
CH2COMe
2-tBu—Ph


2708
3-F
CH2COMe
2-CH2CO2Me—Ph


2709
3-F
CH2COMe
2-(1-piperidinyl)-Ph


2710
3-F
CH2COMe
2-(1-pyrrolidinyl)-Ph


2711
3-F
CH2COMe
2-(2-imidazolyl)-Ph


2712
3-F
CH2COMe
2-(1-imidazolyl)-Ph


2713
3-F
CH2COMe
2-(2-thiazolyl)-Ph


2714
3-F
CH2COMe
2-(3-pyrazolyl)-Ph


2715
3-F
CH2COMe
2-(1-pyrazolyl)-Ph


2716
3-F
CH2COMe
2-(5-Me-1-tetrazolyl)-Ph


2717
3-F
CH2COMe
2-(1-Me-5-tetrazolyl)-Ph


2718
3-F
CH2COMe
2-(2-pyridyl)-Ph


2719
3-F
CH2COMe
2-(2-thienyl)-Ph


2720
3-F
CH2COMe
2-(2-furanyl)-Ph


2721
3-F
CH2COMe
2,4-diF—Ph


2722
3-F
CH2COMe
2,5-diF—Ph


2723
3-F
CH2COMe
2,6-diF—Ph


2724
3-F
CH2COMe
3,4-diF—Ph


2725
3-F
CH2COMe
3,5-diF—Ph


2726
3-F
CH2COMe
2,4-diCl—Ph


2727
3-F
CH2COMe
2,5-diCl—Ph


2728
3-F
CH2COMe
2,6-diCl—Ph


2729
3-F
CH2COMe
3,4-diCl—Ph


2730
3-F
CH2COMe
3,5-diCl—Ph


2731
3-F
CH2COMe
3,4-diCF3—Ph


2732
3-F
CH2COMe
3,5-diCF3—Ph


2733
3-F
CH2COMe
5-Cl-2-MeO—Ph


2734
3-F
CH2COMe
5-Cl-2-Me—Ph


2735
3-F
CH2COMe
2-F-5-Me—Ph


2736
3-F
CH2COMe
3-F-5-morpholino-Ph


2737
3-F
CH2COMe
3,4-OCH2O—Ph


2738
3-F
CH2COMe
3,4-OCH2CH2O—Ph


2739
3-F
CH2COMe
2-MeO-5-CONH2—Ph


2740
3-F
CH2COMe
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


2741
3-F
CH2COMe
2-MeO-5-(1-Me-5-tetrazolyl)-Ph


2742
3-F
CH2COMe
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


2743
3-F
CH2COMe
1-naphthyl


2744
3-F
CH2COMe
2-naphthyl


2745
3-F
CH2COMe
2-thienyl


2746
3-F
CH2COMe
3-thienyl


2747
3-F
CH2COMe
2-furanyl


2748
3-F
CH2COMe
3-furanyl


2749
3-F
CH2COMe
2-pyridyl


2750
3-F
CH2COMe
3-pyridyl


2751
3-F
CH2COMe
4-pyridyl


2752
3-F
CH2COMe
2-indolyl


2753
3-F
CH2COMe
3-indolyl


2754
3-F
CH2COMe
5-indolyl


2755
3-F
CH2COMe
6-indolyl


2756
3-F
CH2COMe
3-indazolyl


2757
3-F
CH2COMe
5-indazolyl


2758
3-F
CH2COMe
6-indazolyl


2759
3-F
CH2COMe
2-imidazolyl


2760
3-F
CH2COMe
3-isoxazoyl


2761
3-F
CH2COMe
3-pyrazolyl


2762
3-F
CH2COMe
2-thiadiazolyl


2763
3-F
CH2COMe
2-thiazolyl


2764
3-F
CH2COMe
5-Ac-4-Me-2-thiazolyl


2765
3-F
CH2COMe
5-tetrazolyl


2766
3-F
CH2COMe
2-benzimidazolyl


2767
3-F
CH2COMe
5-benzimidazolyl


2768
3-F
CH2COMe
2-benzothiazolyl


2769
3-F
CH2COMe
5-benzothiazolyl


2770
3-F
CH2COMe
2-benzoxazolyl


2771
3-F
CH2COMe
5-benzoxazolyl


2772
3-F
CH2COMe
1-adamantyl


2773
3-F
CH2COMe
2-adamantyl


2774
3-F
CH2COMe
i-Pr


2775
3-F
CH2COMe
t-Bu


2776
3-F
CH2COMe
c-Hex


2777
3-F
CH2COMe
CH2CH2OMe


2778
3-F
CH2COMe
CH2CONH2


2779
3-F
CH2COMe
CH2CO2Me


2780
3-F
CH2COMe
CH(CH2Ph)CO2Me


2781
3-F
CH2COMe
CH2CH2NMe2


2782
3-F
CH2COMe
benzyl


2783
3-F
CH2COMe
phenethyl


2784
3-F
CH2COMe
2-(morpholin-1-yl)-Et


2785
4-F
H
Ph


2786
4-F
H
3-CN—Ph


2787
4-F
H
3-COMe—Ph


2788
4-F
H
3-CO2Me—Ph


2789
4-F
H
3-CONH2—Ph


2790
4-F
H
3-CONHMe—Ph


2791
4-F
H
3-F—Ph


2792
4-F
H
3-Cl—Ph


2793
4-F
H
3-Br—Ph


2794
4-F
H
3-SO2NH2—Ph


2795
4-F
H
3-SO2NHMe—Ph


2796
4-F
H
3-CF3—Ph


2797
4-F
H
3-OMe—Ph


2798
4-F
H
3-SMe—Ph


2799
4-F
H
3-SOMe—Ph


2800
4-F
H
3-SO2Me—Ph


2801
4-F
H
3-OH—Ph


2802
4-F
H
3-CH2OH—Ph


2803
4-F
H
3-CHOHMe—Ph


2804
4-F
H
3-COH(Me)2—Ph


2805
4-F
H
3-Me—Ph


2806
4-F
H
3-Et—Ph


2807
4-F
H
3-iPr—Ph


2808
4-F
H
3-tBu—Ph


2809
4-F
H
3-CH2CO2Me—Ph


2810
4-F
H
3-(1-piperidinyl)-Ph


2811
4-F
H
3-(1-pyrrolidinyl)-Ph


2812
4-F
H
3-(2-imidazolyl)-Ph


2813
4-F
H
3-(1-imidazolyl)-Ph


2814
4-F
H
3-(2-thiazolyl)-Ph


2815
4-F
H
3-(3-pyrazolyl)-Ph


2816
4-F
H
3-(1-pyrazolyl)-Ph


2817
4-F
H
3-(5-Me-1-tetrazolyl)-Ph


2818
4-F
H
3-(1-Me-5-tetrazolyl)-Ph


2819
4-F
H
3-(2-pyridyl)-Ph


2820
4-F
H
3-(2-thienyl)-Ph


2821
4-F
H
3-(2-furanyl)-Ph


2822
4-F
H
4-CN—Ph


2823
4-F
H
4-COMe—Ph


2824
4-F
H
4-CO2Me—Ph


2825
4-F
H
4-CONH2—Ph


2826
4-F
H
4-CONHMe—Ph


2827
4-F
H
4-CONHPh—Ph


2828
4-F
H
4-F—Ph


2829
4-F
H
4-Cl—Ph


2830
4-F
H
4-Br—Ph


2831
4-F
H
4-SO2NH2—Ph


2832
4-F
H
4-SO2NHMe—Ph


2833
4-F
H
4-CF3—Ph


2834
4-F
H
4-OMe—Ph


2835
4-F
H
4-SMe—Ph


2836
4-F
H
4-SOMe—Ph


2837
4-F
H
4-SO2Me—Ph


2838
4-F
H
4-OH—Ph


2839
4-F
H
4-CH2OH—Ph


2840
4-F
H
4-CHOHMe—Ph


2841
4-F
H
4-COH(Me)2—Ph


2842
4-F
H
4-Me—Ph


2843
4-F
H
4-Et—Ph


2844
4-F
H
4-iPr—Ph


2845
4-F
H
4-tBu—Ph


2846
4-F
H
4-CH2CO2Me—Ph


2847
4-F
H
4-(1-piperidinyl)-Ph


2848
4-F
H
4-(1-pyrrolidinyl)-Ph


2849
4-F
H
4-(2-imidazolyl)-Ph


2850
4-F
H
4-(1-imidazolyl)-Ph


2851
4-F
H
4-(2-thiazolyl)-Ph


2852
4-F
H
4-(3-pyrazolyl)-Ph


2853
4-F
H
4-(1-pyrazolyl)-Ph


2854
4-F
H
4-(5-Me-1-tetrazolyl)-Ph


2855
4-F
H
4-(1-Me-5-tetrazolyl)-Ph


2856
4-F
H
4-(2-pyridyl)-Ph


2857
4-F
H
4-(2-thienyl)-Ph


2858
4-F
H
4-(2-furanyl)-Ph


2859
4-F
H
2-CN—Ph


2860
4-F
H
2-COMe—Ph


2861
4-F
H
2-CO2Me—Ph


2862
4-F
H
2-CONH2—Ph


2863
4-F
H
2-CONHMe—Ph


2864
4-F
H
2-F—Ph


2865
4-F
H
2-Cl—Ph


2866
4-F
H
2-Br—Ph


2867
4-F
H
2-SO2NH2—Ph


2868
4-F
H
2-SO2NHMe—Ph


2869
4-F
H
2-CF3—Ph


2870
4-F
H
2-OMe—Ph


2871
4-F
H
2-SMe—Ph


2872
4-F
H
2-SOMe—Ph


2873
4-F
H
2-SO2Me—Ph


2874
4-F
H
2-OH—Ph


2875
4-F
H
2-CH2OH—Ph


2876
4-F
H
2-CHOHMe—Ph


2877
4-F
H
2-COH(Me)2—Ph


2878
4-F
H
2-Me—Ph


2879
4-F
H
2-Et—Ph


2880
4-F
H
2-iPr—Ph


2881
4-F
H
2-tBu—Ph


2882
4-F
H
2-CH2CO2Me—Ph


2883
4-F
H
2-(1-piperidinyl)-Ph


2884
4-F
H
2-(1-pyrrolidinyl)-Ph


2885
4-F
H
2-(2-imidazolyl)-Ph


2886
4-F
H
2-(1-imidazolyl)-Ph


2887
4-F
H
2-(2-thiazolyl)-Ph


2888
4-F
H
2-(3-pyrazolyl)-Ph


2889
4-F
H
2-(1-pyrazolyl)-Ph


2890
4-F
H
2-(5-Me-1-tetrazolyl)-Ph


2891
4-F
H
2-(1-Me-5-tetrazolyl)-Ph


2892
4-F
H
2-(2-pyridyl)-Ph


2893
4-F
H
2-(2-thienyl)-Ph


2894
4-F
H
2-(2-furanyl)-Ph


2895
4-F
H
2,4-diF—Ph


2896
4-F
H
2,5-diF—Ph


2897
4-F
H
2,6-diF—Ph


2898
4-F
H
3,4-diF—Ph


2899
4-F
H
3,5-diF—Ph


2900
4-F
H
2,4-diCl—Ph


2901
4-F
H
2,5-diCl—Ph


2902
4-F
H
2,6-diCl—Ph


2903
4-F
H
3,4-diCl—Ph


2904
4-F
H
3,5-diCl—Ph


2905
4-F
H
3,4-diCF3—Ph


2906
4-F
H
3,5-diCF3—Ph


2907
4-F
H
5-Cl-2-MeO—Ph


2908
4-F
H
5-Cl-2-Me—Ph


2909
4-F
H
2-F-5-Me—Ph


2910
4-F
H
3-F-5-morpholino-Ph


2911
4-F
H
3,4-OCH2O—Ph


2912
4-F
H
3,4-OCH2CH2O—Ph


2913
4-F
H
2-MeO-5-CONH2—Ph


2914
4-F
H
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


2915
4-F
H
2-MeO-5-(1-Me-5-tetrazolyl)-Ph


2916
4-F
H
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


2917
4-F
H
1-naphthyl


2918
4-F
H
2-naphthyl


2919
4-F
H
2-thienyl


2920
4-F
H
3-thienyl


2921
4-F
H
2-furanyl


2922
4-F
H
3-furanyl


2923
4-F
H
2-pyridyl


2924
4-F
H
3-pyridyl


2925
4-F
H
4-pyridyl


2926
4-F
H
2-indolyl


2927
4-F
H
3-indolyl


2928
4-F
H
5-indolyl


2929
4-F
H
6-indolyl


2930
4-F
H
3-indazolyl


2931
4-F
H
5-indazolyl


2932
4-F
H
6-indazolyl


2933
4-F
H
2-imidazolyl


2934
4-F
H
3-isoxazoyl


2935
4-F
H
3-pyrazolyl


2936
4-F
H
2-thiadiazolyl


2937
4-F
H
2-thiazolyl


2938
4-F
H
5-Ac-4-Me-2-thiazolyl


2939
4-F
H
5-tetrazolyl


2940
4-F
H
2-benzimidazolyl


2941
4-F
H
5-benzimidazolyl


2942
4-F
H
2-benzothiazolyl


2943
4-F
H
5-benzothiazolyl


2944
4-F
H
2-benzoxazolyl


2945
4-F
H
5-benzoxazolyl


2946
4-F
H
1-adamantyl


2947
4-F
H
2-adamantyl


2948
4-F
H
i-Pr


2949
4-F
H
t-Bu


2950
4-F
H
c-Hex


2951
4-F
H
CH2CH2OMe


2952
4-F
H
CH2CONH2


2953
4-F
H
CH2CO2Me


2954
4-F
H
CH(CH2Ph)CO2Me


2955
4-F
H
CH2CH2NMe2


2956
4-F
H
benzyl


2957
4-F
H
phenethyl


2958
4-F
H
2-(morpholino-1-yl)-Et


2959
4-F
Me
Ph


2960
4-F
Me
3-CN—Ph


2961
4-F
Me
3-COMe—Ph


2962
4-F
Me
3-CO2Me—Ph


2963
4-F
Me
3-CONH2—Ph


2964
4-F
Me
3-CONHMe—Ph


2965
4-F
Me
3-F—Ph


2966
4-F
Me
3-Cl—Ph


2967
4-F
Me
3-Br—Ph


2968
4-F
Me
3-SO2NH2—Ph


2969
4-F
Me
3-SO2NHMe—Ph


2970
4-F
Me
3-CF3—Ph


2971
4-F
Me
3-OMe—Ph


2972
4-F
Me
3-SMe—Ph


2973
4-F
Me
3-SOMe—Ph


2974
4-F
Me
3-SO2Me—Ph


2975
4-F
Me
3-OH—Ph


2976
4-F
Me
3-CH2OH—Ph


2977
4-F
Me
3-CHOHMe—Ph


2978
4-F
Me
3-COH(Me)2—Ph


2979
4-F
Me
3-Me—Ph


2980
4-F
Me
3-Et—Ph


2981
4-F
Me
3-iPr—Ph


2982
4-F
Me
3-tBu—Ph


2983
4-F
Me
3-CH2CO2Me—Ph


2984
4-F
Me
3-(1-piperidinyl)-Ph


2985
4-F
Me
3-(1-pyrrolidinyl)-Ph


2986
4-F
Me
3-(2-imidazolyl)-Ph


2987
4-F
Me
3-(1-imidazolyl)-Ph


2988
4-F
Me
3-(2-thiazolyl)-Ph


2989
4-F
Me
3-(3-pyrazolyl)-Ph


2990
4-F
Me
3-(1-pyrazolyl)-Ph


2991
4-F
Me
3-(5-Me-1-tetrazolyl)-Ph


2992
4-F
Me
3-(1-Me-5-tetrazolyl)-Ph


2993
4-F
Me
3-(2-pyridyl)-Ph


2994
4-F
Me
3-(2-thienyl)-Ph


2995
4-F
Me
3-(2-furanyl)-Ph


2996
4-F
Me
4-CN—Ph


2997
4-F
Me
4-COMe—Ph


2998
4-F
Me
4-CO2Me—Ph


2999
4-F
Me
4-CONH2—Ph


3000
4-F
Me
4-CONHMe—Ph


3001
4-F
Me
4-CONHPh—Ph


3002
4-F
Me
4-F—Ph


3003
4-F
Me
4-Cl—Ph


3004
4-F
Me
4-Br—Ph


3005
4-F
Me
4-SO2NH2—Ph


3006
4-F
Me
4-SO2NHMe—Ph


3007
4-F
Me
4-CF3—Ph


3008
4-F
Me
4-OMe—Ph


3009
4-F
Me
4-SMe—Ph


3010
4-F
Me
4-SOMe—Ph


3011
4-F
Me
4-SO2Me—Ph


3012
4-F
Me
4-OH—Ph


3013
4-F
Me
4-CH2OH—Ph


3014
4-F
Me
4-CHOHMe—Ph


3015
4-F
Me
4-COH(Me)2—Ph


3016
4-F
Me
4-Me—Ph


3017
4-F
Me
4-Et—Ph


3018
4-F
Me
4-iPr—Ph


3019
4-F
Me
4-tBu—Ph


3020
4-F
Me
4-CH2CO2Me—Ph


3021
4-F
Me
4-(1-piperidinyl)-Ph


3022
4-F
Me
4-(1-pyrrolidinyl)-Ph


3023
4-F
Me
4-(2-imidazolyl)-Ph


3024
4-F
Me
4-(1-imidazolyl)-Ph


3025
4-F
Me
4-(2-thiazolyl)-Ph


3026
4-F
Me
4-(3-pyrazolyl)-Ph


3027
4-F
Me
4-(1-pyrazolyl)-Ph


3028
4-F
Me
4-(5-Me-1-tetrazolyl)-Ph


3029
4-F
Me
4-(1-Me-5-tetrazolyl)-Ph


3030
4-F
Me
4-(2-pyridyl)-Ph


3031
4-F
Me
4-(2-thienyl)-Ph


3032
4-F
Me
4-(2-furanyl)-Ph


3033
4-F
Me
2-CN—Ph


3034
4-F
Me
2-COMe—Ph


3035
4-F
Me
2-CO2Me—Ph


3036
4-F
Me
2-CONH2—Ph


3037
4-F
Me
2-CONHMe—Ph


3038
4-F
Me
2-F—Ph


3039
4-F
Me
2-Cl—Ph


3040
4-F
Me
2-Br—Ph


3041
4-F
Me
2-SO2NH2—Ph


3042
4-F
Me
2-SO2NHMe—Ph


3043
4-F
Me
2-CF3—Ph


3044
4-F
Me
2-OMe—Ph


3045
4-F
Me
2-SMe—Ph


3046
4-F
Me
2-SOMe—Ph


3047
4-F
Me
2-SO2Me—Ph


3048
4-F
Me
2-OH—Ph


3049
4-F
Me
2-CH2OH—Ph


3050
4-F
Me
2-CHOHMe—Ph


3051
4-F
Me
2-COH(Me)2—Ph


3052
4-F
Me
2-Me—Ph


3053
4-F
Me
2-Et—Ph


3054
4-F
Me
2-iPr—Ph


3055
4-F
Me
2-tBu—Ph


3056
4-F
Me
2-CH2CO2Me—Ph


3057
4-F
Me
2-(1-piperidinyl)-Ph


3058
4-F
Me
2-(1-pyrrolidinyl)-Ph


3059
4-F
Me
2-(2-imidazolyl)-Ph


3060
4-F
Me
2-(1-imidazolyl)-Ph


3061
4-F
Me
2-(2-thiazolyl)-Ph


3062
4-F
Me
2-(3-pyrazolyl)-Ph


3063
4-F
Me
2-(1-pyrazolyl)-Ph


3064
4-F
Me
2-(5-Me-1-tetrazolyl)-Ph


3065
4-F
Me
2-(1-Me-5-tetrazolyl)-Ph


3066
4-F
Me
2-(2-pyridyl)-Ph


3067
4-F
Me
2-(2-thienyl)-Ph


3068
4-F
Me
2-(2-furanyl)-Ph


3069
4-F
Me
2,4-diF—Ph


3070
4-F
Me
2,5-diF—Ph


3071
4-F
Me
2,6-diF—Ph


3072
4-F
Me
3,4-diF—Ph


3073
4-F
Me
3,5-diF—Ph


3074
4-F
Me
2,4-diCl—Ph


3075
4-F
Me
2,5-diCl—Ph


3076
4-F
Me
2,6—diCl—Ph


3077
4-F
Me
3,4-diCl—Ph


3078
4-F
Me
3,5-diCl—Ph


3079
4-F
Me
3,4-diCF3—Ph


3080
4-F
Me
3,5-diCF3—Ph


3081
4-F
Me
5-Cl-2-MeO—Ph


3082
4-F
Me
5-Cl-2-Me—Ph


3083
4-F
Me
2-F-5-Me—Ph


3084
4-F
Me
3-F-5-rnorpholino-Ph


3085
4-F
Me
3,4-OCH2O—Ph


3086
4-F
Me
3,4-OCH2CH2O—Ph


3087
4-F
Me
2-MeO-5-CONH2—Ph


3088
4-F
Me
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


3089
4-F
Me
2-MeO-5-(1-Me-5-tetrazolyl)-Ph


3090
4-F
Me
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


3091
4-F
Me
1-naphthyl


3092
4-F
Me
2-naphthyl


3093
4-F
Me
2-thienyl


3094
4-F
Me
3-thienyl


3095
4-F
Me
2-furanyl


3096
4-F
Me
3-furanyl


3097
4-F
Me
2-pyridyl


3098
4-F
Me
3-pyridyl


3099
4-F
Me
4-pyridyl


3100
4-F
Me
2-indolyl


3101
4-F
Me
3-indolyl


3102
4-F
Me
5-indolyl


3103
4-F
Me
6-indolyl


3104
4-F
Me
3-indazolyl


3105
4-F
Me
5-indazolyl


3106
4-F
Me
6-indazolyl


3107
4-F
Me
2-imidazolyl


3108
4-F
Me
3-isoxazoyl


3109
4-F
Me
3-pyrazolyl


3110
4-F
Me
2-thiadiazolyl


3111
4-F
Me
2-thiazolyl


3112
4-F
Me
5-Ac-4-Me-2-thiazolyl


3113
4-F
Me
5-tetrazolyl


3114
4-F
Me
2-benzimidazolyl


3115
4-F
Me
5-benzimidazolyl


3116
4-F
Me
2-benzothiazolyl


3117
4-F
Me
5-benzothiazolyl


3118
4-F
Me
2-benzoxazolyl


3119
4-F
Me
5-benzoxazolyl


3120
4-F
Me
1-adamantyl


3121
4-F
Me
2-adamantyl


3122
4-F
Me
i-Pr


3123
4-F
Me
t-Bu


3124
4-F
Me
c-Hex


3125
4-F
Me
CH2CH2OMe


3126
4-F
Me
CH2CONH2


3127
4-F
Me
CH2CO2Me


3128
4-F
Me
CH(CH2Ph)CO2Me


3129
4-F
Me
CH2CH2NMe2


3130
4-F
Me
benzyl


3131
4-F
Me
phenethyl


3132
4-F
Me
2-(morpholin-1-yl)-Et


3133
4-F
2-F—Et
Ph


3134
4-F
2-F—Et
3-CN—Ph


3135
4-F
2-F—Et
3-COMe—Ph


3136
4-F
2-F—Et
3-CO2Me—Ph


3137
4-F
2-F—Et
3-CONH2—Ph


3138
4-F
2-F—Et
3-CONHMe—Ph


3139
4-F
2-F—Et
3-F—Ph


3140
4-F
2-F—Et
3-Cl—Ph


3141
4-F
2-F—Et
3-Br—Ph


3142
4-F
2-F—Et
3-SO2NH2—Ph


3143
4-F
2-F—Et
3-SO2NHMe—Ph


3144
4-F
2-F—Et
3-CF3—Ph


3145
4-F
2-F—Et
3-OMe—Ph


3146
4-F
2-F—Et
3-SMe—Ph


3147
4-F
2-F—Et
3-SOMe—Ph


3148
4-F
2-F—Et
3-SO2Me—Ph


3149
4-F
2-F—Et
3-OH—Ph


3150
4-F
2-F—Et
3-CH2OH—Ph


3151
4-F
2-F—Et
3-CHOHMe—Ph


3152
4-F
2-F—Et
3-COH(Me)2—Ph


3153
4-F
2-F—Et
3-Me—Ph


3154
4-F
2-F—Et
3-Et—Ph


3155
4-F
2-F—Et
3-iPr—Ph


3156
4-F
2-F—Et
3-tBu—Ph


3157
4-F
2-F—Et
3-CH2CO2Me—Ph


3158
4-F
2-F—Et
3-(1-piperidinyl)-Ph


3159
4-F
2-F—Et
3-(1-pyrrolidinyl)-Ph


3160
4-F
2-F—Et
3-(2-imidazolyl)-Ph


3161
4-F
2-F—Et
3-(1-imidazolyl)-Ph


3162
4-F
2-F—Et
3-(2-thiazolyl)-Ph


3163
4-F
2-F—Et
3-(3-pyrazolyl)-Ph


3164
4-F
2-F—Et
3-(1-pyrazolyl)-Ph


3165
4-F
2-F—Et
3-(5-Me-1-tetrazolyl)-Ph


3166
4-F
2-F—Et
3-(1-Me-5-tetrazolyl)-Ph


3167
4-F
2-F—Et
3-(2-pyridyl)-Ph


3168
4-F
2-F—Et
3-(2-thienyl)-Ph


3169
4-F
2-F—Et
3-(2-furanyl)-Ph


3170
4-F
2-F—Et
4-CN—Ph


3171
4-F
2-F—Et
4-COMe—Ph


3172
4-F
2-F—Et
4-CO2Me—Ph


3173
4-F
2-F—Et
4-CONH2—Ph


3174
4-F
2-F—Et
4-CONHMe—Ph


3175
4-F
2-F—Et
4-CONHPh—Ph


3176
4-F
2-F—Et
4-F—Ph


3177
4-F
2-F—Et
4-Cl—Ph


3178
4-F
2-F—Et
4-Br—Ph


3179
4-F
2-F—Et
4-SO2NH2—Ph


3180
4-F
2-F—Et
4-SO2NHMe—Ph


3181
4-F
2-F—Et
4-CF3—Ph


3182
4-F
2-F—Et
4-OMe—Ph


3183
4-F
2-F—Et
4-SMe—Ph


3184
4-F
2-F—Et
4-SOMe—Ph


3185
4-F
2-F—Et
4-SO2Me—Ph


3186
4-F
2-F—Et
4-OH—Ph


3187
4-F
2-F—Et
4-CH2OH—Ph


3188
4-F
2-F—Et
4-CHOHMe—Ph


3189
4-F
2-F—Et
4-COH(Me)2—Ph


3190
4-F
2-F—Et
4-Me—Ph


3191
4-F
2-F—Et
4-Et—Ph


3192
4-F
2-F—Et
4-iPr—Ph


3193
4-F
2-F—Et
4-tBu—Ph


3194
4-F
2-F—Et
4-CH2CO2Me—Ph


3195
4-F
2-F—Et
4-(1-piperidinyl)-Ph


3196
4-F
2-F—Et
4-(1-pyrrolidinyl)-Ph


3197
4-F
2-F—Et
4-(2-imidazolyl)-Ph


3198
4-F
2-F—Et
4-(1-imidazolyl)-Ph


3199
4-F
2-F—Et
4-(2-thiazolyl)-Ph


3200
4-F
2-F—Et
4-(3-pyrazolyl)-Ph


3201
4-F
2-F—Et
4-(1-pyrazolyl)-Ph


3202
4-F
2-F—Et
4-(5-Me-1-tetrazolyl)-Ph


3203
4-F
2-F—Et
4-(1-Me-5-tetrazolyl)-Ph


3204
4-F
2-F—Et
4-(2-pyridyl)-Ph


3205
4-F
2-F—Et
4-(2-thienyl)-Ph


3206
4-F
2-F—Et
4-(2-furanyl)-Ph


3207
4-F
2-F—Et
2-CN—Ph


3208
4-F
2-F—Et
2-COMe—Ph


3209
4-F
2-F—Et
2-CO2Me—Ph


3210
4-F
2-F—Et
2-CONH2—Ph


3211
4-F
2-F—Et
2-CONHMe—Ph


3212
4-F
2-F—Et
2-F—Ph


3213
4-F
2-F—Et
2-Cl—Ph


3214
4-F
2-F—Et
2-Br—Ph


3215
4-F
2-F—Et
2-SO2NH2—Ph


3216
4-F
2-F—Et
2-SO2NHMe—Ph


3217
4-F
2-F—Et
2-CF3—Ph


3218
4-F
2-F—Et
2-OMe—Ph


3219
4-F
2-F—Et
2-SMe—Ph


3220
4-F
2-F—Et
2-SOMe—Ph


3221
4-F
2-F—Et
2-SO2Me—Ph


3222
4-F
2-F—Et
2-OH—Ph


3223
4-F
2-F—Et
2-CH2OH—Ph


3224
4-F
2-F—Et
2-CHOHMe—Ph


3225
4-F
2-F—Et
2-COH(Me)2—Ph


3226
4-F
2-F—Et
2-Me—Ph


3227
4-F
2-F—Et
2-Et—Ph


3228
4-F
2-F—Et
2-iPr—Ph


3229
4-F
2-F—Et
2-tBu—Ph


3230
4-F
2-F—Et
2-CH2CO2Me—Ph


3231
4-F
2-F—Et
2-(1-piperidinyl)-Ph


3232
4-F
2-F—Et
2-(1-pyrrolidinyl)-Ph


3233
4-F
2-F—Et
2-(2-imidazolyl)-Ph


3234
4-F
2-F—Et
2-(1-imidazolyl)-Ph


3235
4-F
2-F—Et
2-(2-thiazolyl)-Ph


3236
4-F
2-F—Et
2-(3-pyrazolyl)-Ph


3237
4-F
2-F—Et
2-(1-pyrazolyl)-Ph


3238
4-F
2-F—Et
2-(5-Me-1-tetrazolyl)-Ph


3239
4-F
2-F—Et
2-(1-Me-5-tetrazolyl)-Ph


3240
4-F
2-F—Et
2-(2-pyridyl)-Ph


3241
4-F
2-F—Et
2-(2-thienyl)-Ph


3242
4-F
2-F—Et
2-(2-furanyl)-Ph


3243
4-F
2-F—Et
2,4-diF—Ph


3244
4-F
2-F—Et
2,5-diF—Ph


3245
4-F
2-F—Et
2,6-diF—Ph


3246
4-F
2-F—Et
3,4-diF—Ph


3247
4-F
2-F—Et
3,5-diF—Ph


3248
4-F
2-F—Et
2,4-diCl—Ph


3249
4-F
2-F—Et
2,5-diCl—Ph


3250
4-F
2-F—Et
2,6-diCl—Ph


3251
4-F
2-F—Et
3,4-diCl—Ph


3252
4-F
2-F—Et
3,5-diCl—Ph


3253
4-F
2-F—Et
3,4-diCF3—Ph


3254
4-F
2-F—Et
3,5-diCF3—Ph


3255
4-F
2-F—Et
5-Cl-2-MeO—Ph


3256
4-F
2-F—Et
5-Cl-2-Me—Ph


3257
4-F
2-F—Et
2-F-5-Me—Ph


3258
4-F
2-F—Et
3-F-5-morpholino-Ph


3259
4-F
2-F—Et
3,4-OCH2O—Ph


3260
4-F
2-F—Et
3,4-OCH2CH2O—Ph


3261
4-F
2-F—Et
2-MeO-5-CONH2—Ph


3262
4-F
2-F—Et
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


3263
4-F
2-F—Et
2-MeO-5-(1-Me-5-tetrazolyl)-Ph


3264
4-F
2-F—Et
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


3265
4-F
2-F—Et
1-naphthyl


3266
4-F
2-F—Et
2-naphthyl


3267
4-F
2-F—Et
2-thienyl


3268
4-F
2-F—Et
3-thienyl


3269
4-F
2-F—Et
2-furanyl


3270
4-F
2-F—Et
3-furanyl


3271
4-F
2-F—Et
2-pyridyl


3272
4-F
2-F—Et
3-pyridyl


3273
4-F
2-F—Et
4-pyridyl


3274
4-F
2-F—Et
2-indolyl


3275
4-F
2-F—Et
3-indolyl


3276
4-F
2-F—Et
5-indolyl


3277
4-F
2-F—Et
6-indolyl


3278
4-F
2-F—Et
3-indazolyl


3279
4-F
2-F—Et
5-indazolyl


3280
4-F
2-F—Et
6-indazolyl


3281
4-F
2-F—Et
2-imidazolyl


3282
4-F
2-F—Et
3-isoxazoyl


3283
4-F
2-F—Et
3-pyrazolyl


3284
4-F
2-F—Et
2-thiadiazolyl


3285
4-F
2-F—Et
2-thiazolyl


3286
4-F
2-F—Et
5-Ac-4-Me-2-thiazolyl


3287
4-F
2-F—Et
5-tetrazolyl


3288
4-F
2-F—Et
2-benzimidazolyl


3289
4-F
2-F—Et
5-benzimidazolyl


3290
4-F
2-F—Et
2-benzothiazolyl


3291
4-F
2-F—Et
5-benzothiazolyl


3292
4-F
2-F—Et
2-benzoxazolyl


3293
4-F
2-F—Et
5-benzoxazolyl


3294
4-F
2-F—Et
1-adamanlyl


3295
4-F
2-F—Et
2-adamanlyl


3296
4-F
2-F—Et
i-Pr


3297
4-F
2-F—Et
t-Bu


3298
4-F
2-F—Et
c-Hex


3299
4-F
2-F—Et
CH2CH2OMe


3300
4-F
2-F—Et
CH2CONH2


3301
4-F
2-F—Et
CH2CO2Me


3302
4-F
2-F—Et
CH(CH2Ph)CO2Me


3303
4-F
2-F—Et
CH2CH2NMe2


3304
4-F
2-F—Et
benzyl


3305
4-F
2-F—Et
phenethyl


3306
4-F
2-F—Et
2-(morpholin-1-yl)-Et


3307
4-F
CO2Me
Ph


3308
4-F
CO2Me
3-CN—Ph


3309
4-F
CO2Me
3-COMe—Ph


3310
4-F
CO2Me
3-CO2Me—Ph


3311
4-F
CO2Me
3-CONH2—Ph


3312
4-F
CO2Me
3-CONHMe—Ph


3313
4-F
CO2Me
3-F—Ph


3314
4-F
CO2Me
3-Cl—Ph


3315
4-F
CO2Me
3-Br—Ph


3316
4-F
CO2Me
3-SO2NH2—Ph


3317
4-F
CO2Me
3-SO2NHMe—Ph


3318
4-F
CO2Me
3-CF3—Ph


3319
4-F
CO2Me
3-OMe—Ph


3320
4-F
CO2Me
3-SMe—Ph


3321
4-F
CO2Me
3-SOMe—Ph


3322
4-F
CO2Me
3-SO2Me—Ph


3323
4-F
CO2Me
3-OH—Ph


3324
4-F
CO2Me
3-CH2OH—Ph


3325
4-F
CO2Me
3-CHOHMe—Ph


3326
4-F
CO2Me
3-COH(Me)2—Ph


3327
4-F
CO2Me
3-Me—Ph


3328
4-F
CO2Me
3-Et—Ph


3329
4-F
CO2Me
3-iPr—Ph


3330
4-F
CO2Ne
3-tBu—Ph


3331
4-F
CO2Me
3-CH2CO2Me—Ph


3332
4-F
CO2Me
3-(1-piperidinyl)-Ph


3333
4-F
CO2Me
3-(1-pyrrolidinyl)-Ph


3334
4-F
CO2Me
3-(2-imidazolyl)-Ph


3335
4-F
CO2Me
3-(1-imidazolyl)-Ph


3336
4-F
CO2Me
3-(2-thiazolyl)-Ph


3337
4-F
CO2Me
3-(3-pyrazolyl)-Ph


3338
4-F
CO2Me
3-(1-pyrazolyl)-Ph


3339
4-F
CO2Me
3-(5-Me-1-tetrazolyl)-Ph


3340
4-F
CO2Me
3-(1-Me-5-tetrazolyl)-Ph


3341
4-F
CO2Me
3-(2-pyridyl)-Ph


3342
4-F
CO2Me
3-(2-thienyl)-Ph


3343
4-F
CO2Me
3-(2-furanyl)-Ph


3344
4-F
CO2Me
4-CN—Ph


3345
4-F
CO2Me
4-COMe—Ph


3346
4-F
CO2Me
4-CO2Me—Ph


3347
4-F
CO2Me
4-CONH2—Ph


3348
4-F
CO2Me
4-CONHMe—Ph


3349
4-F
CO2Me
4-CONHPh—Ph


3350
4-F
CO2Me
4-F—Ph


3351
4-F
CO2Me
4-Cl—Ph


3352
4-F
CO2Me
4-Br—Ph


3353
4-F
CO2Me
4-SO2NH2—Ph


3354
4-F
CO2Me
4-SO2NHMe—Ph


3355
4-F
CO2Me
4-CF3—Ph


3356
4-F
CO2Me
4-OMe—Ph


3357
4-F
CO2Me
4-SMe—Ph


3358
4-F
CO2Me
4-SOMe—Ph


3359
4-F
CO2Me
4-SO2Me—Ph


3360
4-F
CO2Me
4-OH—Ph


3361
4-F
CO2Me
4-CH2OH—Ph


3362
4-F
CO2Me
4-CHOHMe—Ph


3363
4-F
CO2Me
4-COH(Me)2—Ph


3364
4-F
CO2Me
4-Me—Ph


3365
4-F
CO2Me
4-Et—Ph


3366
4-F
CO2Me
4-iPr—Ph


3367
4-F
CO2Me
4-tBu—Ph


3368
4-F
CO2Me
4-CH2CO2Me—Ph


3369
4-F
CO2Me
4-(1-piperidinyl)-Ph


3370
4-F
CO2Me
4-(1-pyrrolidinyl)-Ph


3371
4-F
CO2Me
4-(2-imidazolyl)-Ph


3372
4-F
CO2Me
4-(1-imidazolyl)-Ph


3373
4-F
CO2Me
4-(2-thiazolyl)-Ph


3374
4-F
CO2Me
4-(3-pyrazolyl)-Ph


3375
4-F
CO2Me
4-(1-pyrazolyl)-Ph


3376
4-F
CO2Me
4-(5-Me-1-tetrazolyl)-Ph


3377
4-F
CO2Me
4-(1-Me-5-tetrazolyl)-Ph


3378
4-F
CO2Me
4-(2-pyridyl)-Ph


3379
4-F
CO2Me
4-(2-thienyl)-Ph


3380
4-F
CO2Me
4-(2-furanyl)-Ph


3381
4-F
CO2Me
2-CN—Ph


3382
4-F
CO2Me
2-COMe—Ph


3383
4-F
CO2Me
2-CO2Me—Ph


3384
4-F
CO2Me
2-CONH2—Ph


3385
4-F
CO2Me
2-CONHMe—Ph


3386
4-F
CO2Me
2-F—Ph


3387
4-F
CO2Me
2-Cl—Ph


3388
4-F
CO2Me
2-Br—Ph


3389
4-F
CO2Me
2-SO2NH2—Ph


3390
4-F
CO2Me
2-SO2NHMe—Ph


3391
4-F
CO2Me
2-CF3—Ph


3392
4-F
CO2Me
2-OMe—Ph


3393
4-F
CO2Me
2-SMe—Ph


3394
4-F
CO2Me
2-SOMe—Ph


3395
4-F
CO2Me
2-SO2Me—Ph


3396
4-F
CO2Me
2-OH—Ph


3397
4-F
CO2Me
2-CH2OH—Ph


3398
4-F
CO2Me
2-CHOHMe—Ph


3399
4-F
CO2Me
2-COH(Me)2—Ph


3400
4-F
CO2Me
2-Me—Ph


3401
4-F
CO2Me
2-Et—Ph


3402
4-F
CO2Me
2-iPr—Ph


3403
4-F
CO2Me
2-tBu—Ph


3404
4-F
CO2Me
2-CH2CO2Me—Ph


3405
4-F
CO2Me
2-(1-piperidinyl)-Ph


3406
4-F
CO2Me
2-(1-pyrrolidinyl)-Ph


3407
4-F
CO2Me
2-(2-imidazolyl)-Ph


3408
4-F
CO2Me
2-(1-irnidazolyl)-Ph


3409
4-F
CO2Me
2-(2-thiazolyl)-Ph


3410
4-F
CO2Me
2-(3-pyrazolyl)-Ph


3411
4-F
CO2Me
2-(1-pyrazolyl)-Ph


3412
4-F
CO2Me
2-(5-Me-1-tetrazolyl)-Ph


3413
4-F
CO2Me
2-(1-Me-5-tetrazolyl)-Ph


3414
4-F
CO2Me
2-(2-pyridyl)-Ph


3415
4-F
CO2Me
2-(2-thienyl)-Ph


3416
4-F
CO2Me
2-(2-furanyl)-Ph


3417
4-F
CO2Me
2,4-diF—Ph


3418
4-F
CO2Me
2,5-diF—Ph


3419
4-F
CO2Me
2,6-diF—Ph


3420
4-F
CO2Me
3,4-diF—Ph


3421
4-F
CO2Me
3,5-diF—Ph


3422
4-F
CO2Me
2,4-diCl—Ph


3423
4-F
CO2Me
2,5-diCl—Ph


3424
4-F
CO2Me
2,6-diCl—Ph


3425
4-F
CO2Me
3,4-diCl—Ph


3426
4-F
CO2Me
3,5-diCl—Ph


3427
4-F
CO2Me
3,4-diCF3—Ph


3428
4-F
CO2Me
3,5-diCF3—Ph


3429
4-F
CO2Me
5-Cl-2-MeO—Ph


3430
4-F
CO2Me
5-Cl-2-Me—Ph


3431
4-F
CO2Me
2-F-5-Me—Ph


3432
4-F
CO2Me
3-F-5-morpholino-Ph


3433
4-F
CO2Me
3,4-OCH2O—Ph


3434
4-F
CO2Me
3,4-OCH2CH2O—Ph


3435
4-F
CO2Me
2-MeO-5-CONH2—Ph


3436
4-F
CO2Me
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


3437
4-F
CO2Me
2-MeO-5-(1-Me-5-tetrazolyl)-Ph


3438
4-F
CO2Me
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


3439
4-F
CO2Me
1-naphthyl


3440
4-F
CO2Me
2-naphthyl


3441
4-F
CO2Me
2-thienyl


3442
4-F
CO2Me
3-thienyl


3443
4-F
CO2Me
2-furanyl


3444
4-F
CO2Me
3-furanyl


3445
4-F
CO2Me
2-pyridyl


3446
4-F
CO2Me
3-pyridyl


3447
4-F
CO2Me
4-pyridyl


3448
4-F
CO2Me
2-indolyl


3449
4-F
CO2Me
3-indolyl


3450
4-F
CO2Me
5-indolyl


3451
4-F
CO2Me
6-indolyl


3452
4-F
CO2Me
3-indazolyl


3453
4-F
CO2Me
5-indazolyl


3454
4-F
CO2Me
6-indazolyl


3455
4-F
CO2Me
2-imidazolyl


3456
4-F
CO2Me
3-isoxazoyl


3457
4-F
CO2Me
3-pyrazolyl


3458
4-F
CO2Me
2-thiadiazolyl


3459
4-F
CO2Me
2-thiazolyl


3460
4-F
CO2Me
5-Ac-4-Me-2-thiazolyl


3461
4-F
CO2Me
5-tetrazolyl


3462
4-F
CO2Me
2-benzimidazolyl


3463
4-F
CO2Me
5-benzimidazolyl


3464
4-F
CO2Me
2-benzothiazolyl


3465
4-F
CO2Me
5-benzothiazolyl


3466
4-F
CO2Me
2-benzoxazolyl


3467
4-F
CO2Me
5-benzoxazolyl


3468
4-F
CO2Me
1-adamantyl


3469
4-F
CO2Me
2-adamantyl


3470
4-F
CO2Me
i-Pr


3471
4-F
CO2Me
t-Bu


3472
4-F
CO2Me
c-Hex


3473
4-F
CO2Me
CH2CH2OMe


3474
4-F
CO2Me
CH2CONH2


3475
4-F
CO2Me
CH2CO2Me


3476
4-F
CO2Me
CH(CH2Ph)CO2Me


3477
4-F
CO2Me
CH2CH2NMe2


3478
4-F
CO2Me
benzyl


3479
4-F
CO2Me
phenethyl


3480
4-F
CO2Me
2-(morpholin-1-yl)-Et


3481
4-F
Ac
Ph


3482
4-F
Ac
3-CN—Ph


3483
4-F
Ac
3-COMe—Ph


3484
4-F
Ac
3-CO2Me—Ph


3485
4-F
Ac
3-CONH2—Ph


3486
4-F
Ac
3-CONHMe—Ph


3487
4-F
Ac
3-F—Ph


3488
4-F
Ac
3-Cl—Ph


3489
4-F
Ac
3-Br—Ph


3490
4-F
Ac
3-SO2NH2—Ph


3491
4-F
Ac
3-SO2NHMe—Ph


3492
4-F
Ac
3-CF3—Ph


3493
4-F
Ac
3-OMe—Ph


3494
4-F
Ac
3-SMe—Ph


3495
4-F
Ac
3-SOMe—Ph


3496
4-F
Ac
3-SO2Me—Ph


3497
4-F
Ac
3-OH—Ph


3498
4-F
Ac
3-CH2OH—Ph


3499
4-F
Ac
3-CHOHMe—Ph


3500
4-F
Ac
3-COH(Me)2—Ph


3501
4-F
Ac
3-Me—Ph


3502
4-F
Ac
3-Et—Ph


3503
4-F
Ac
3-iPr—Ph


3504
4-F
Ac
3-tBu—Ph


3505
4-F
Ac
3-CH2CO2Me—Ph


3506
4-F
Ac
3-(1-piperidinyl)-Ph


3507
4-F
Ac
3-(1-pyrrolidinyl)-Ph


3508
4-F
Ac
3-(2-imidazolyl)-Ph


3509
4-F
Ac
3-(1-imidazolyl)-Ph


3510
4-F
Ac
3-(2-thiazolyl)-Ph


3511
4-F
Ac
3-(3-pyrazolyl)-Ph


3512
4-F
Ac
3-(1-pyrazolyl)-Ph


3513
4-F
Ac
3-(5-Me-1-tetrazolyl)—Ph


3514
4-F
Ac
3-(1-Me-5-tetrazolyl)-Ph


3515
4-F
Ac
3-(2-pyridyl)-Ph


3516
4-F
Ac
3-(2-thienyl)-Ph


3517
4-F
Ac
3-(2-furanyl)-Ph


3518
4-F
Ac
4-CN—Ph


3519
4-F
Ac
4-COMe—Ph


3520
4-F
Ac
4-CO2Me—Ph


3521
4-F
Ac
4-CONH2—Ph


3522
4-F
Ac
4-CONHMe—Ph


3523
4-F
Ac
4-CONHPh—Ph


3524
4-F
Ac
4-F—Ph


3525
4-F
Ac
4-Cl—Ph


3526
4-F
Ac
4-Br—Ph


3527
4-F
Ac
4-SO2NH2—Ph


3528
4-F
Ac
4-SO2NHMe—Ph


3529
4-F
Ac
4-CF3—Ph


3530
4-F
Ac
4-OMe—Ph


3531
4-F
Ac
4-SMe—Ph


3532
4-F
Ac
4-SOMe—Ph


3533
4-F
Ac
4-SO2Me—Ph


3534
4-F
Ac
4-OH—Ph


3535
4-F
Ac
4-CH2OH—Ph


3536
4-F
Ac
4-CHOHMe—Ph


3537
4-F
Ac
4-COH(Me)2—Ph


3538
4-F
Ac
4-Me—Ph


3539
4-F
Ac
4-Et—Ph


3540
4-F
Ac
4-iPr—Ph


3541
4-F
Ac
4-tBu—Ph


3542
4-F
Ac
4-CH2CO2Me—Ph


3543
4-F
Ac
4-(1-piperidnyl)-Ph


3544
4-F
Ac
4-(1-pyrrolidinyl)-Ph


3545
4-F
Ac
4-(2-imidazolyl)-Ph


3546
4-F
Ac
4-(1-imidazolyl)-Ph


3547
4-F
Ac
4-(2-thiazolyl)-Ph


3548
4-F
Ac
4-(3-pyrazolyl)-Ph


3549
4-F
Ac
4-(1-pyrazolyl)-Ph


3550
4-F
Ac
4-(5-Me-1-tetrazolyl)-Ph


3551
4-F
Ac
4-(1-Me-5-tetrazolyl)-Ph


3552
4-F
Ac
4-(2-pyridyl)-Ph


3553
4-F
Ac
4-(2-thienyl)-Ph


3554
4-F
Ac
4-(2-furanyl)-Ph


3555
4-F
Ac
2-CN—Ph


3556
4-F
Ac
2-COMe—Ph


3557
4-F
Ac
2-CO2Me—Ph


3558
4-F
Ac
2-CONH2—Ph


3559
4-F
Ac
2-CONHMe—Ph


3560
4-F
Ac
2-F—Ph


3561
4-F
Ac
2-Cl—Ph


3562
4-F
Ac
2-Br—Ph


3563
4-F
Ac
2-SO2NH2—Ph


3564
4-F
Ac
2-SO2NHMe—Ph


3565
4-F
Ac
2-CF3—Ph


3566
4-F
Ac
2-OMe—Ph


3567
4-F
Ac
2-SMe—Ph


3568
4-F
Ac
2-SOMe—Ph


3569
4-F
Ac
2-SO2Me—Ph


3570
4-F
Ac
2-OH—Ph


3571
4-F
Ac
2-CH2OH—Ph


3572
4-F
Ac
2-CHOHMe—Ph


3573
4-F
Ac
2-COH(Me)2—Ph


3574
4-F
Ac
2-Me—Ph


3575
4-F
Ac
2-Et—Ph


3576
4-F
Ac
2-iPr—Ph


3577
4-F
Ac
2-tBu—Ph


3578
4-F
Ac
2-CH2CO2Me—Ph


3579
4-F
Ac
2-(1-piperidinyl)-Ph


3580
4-F
Ac
2-(1-pyrrolidinyl)-Ph


3581
4-F
Ac
2-(2-imidazolyl)-Ph


3582
4-F
Ac
2-(1-imidazolyl)-Ph


3583
4-F
Ac
2-(2-thiazolyl) -Ph


3584
4-F
Ac
2-(3-pyrazolyl)-Ph


3585
4-F
Ac
2-(1-pyrazolyl)-Ph


3586
4-F
Ac
2-(5-Me-1-tetrazolyl)-Ph


3587
4-F
Ac
2-(1-Me-5-tetrazolyl)-Ph


3588
4-F
Ac
2-(2-pyridyl)-Ph


3589
4-F
Ac
2-(2-thienyl)-Ph


3590
4-F
Ac
2-(2-furanyl)-Ph


3591
4-F
Ac
2,4-diF—Ph


3592
4-F
Ac
2,5-diF—Ph


3593
4-F
Ac
2,6-diF—Ph


3594
4-F
Ac
3,4-diF—Ph


3595
4-F
Ac
3,5-diF—Ph


3596
4-F
Ac
2,4-diCl—Ph


3597
4-F
Ac
2,5-diCl—Ph


3598
4-F
Ac
2,6-diCl—Ph


3599
4-F
Ac
3,4-diCl—Ph


3600
4-F
Ac
3,5-diCl—Ph


3601
4-F
Ac
3,4-diCF3—Ph


3602
4-F
Ac
3,5-diCF3—Ph


3603
4-F
Ac
5-Cl-2-MeO—Ph


3604
4-F
Ac
5-Cl-2-Me—Ph


3605
4-F
Ac
2-F-5-Me—Ph


3606
4-F
Ac
3-F-5-morpholino-Ph


3607
4-F
Ac
3,4-OCH2O—Ph


3608
4-F
Ac
3,4-OCH2CH2O—Ph


3609
4-F
Ac
2-MeO-5-CONH2—Ph


3610
4-F
Ac
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


3611
4-F
Ac
2-MeO-5-(1-Me-5-tetrazolyl)-Ph


3612
4-F
Ac
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


3613
4-F
Ac
1-naphthyl


3614
4-F
Ac
2-naphthyl


3615
4-F
Ac
2-thienyl


3616
4-F
Ac
3-thienyl


3617
4-F
Ac
2-furanyl


3618
4-F
Ac
3-furanyl


3619
4-F
Ac
2-pyridyl


3620
4-F
Ac
3-pyridyl


3621
4-F
Ac
4-pyridyl


3622
4-F
Ac
2-indolyl


3623
4-F
Ac
3-indolyl


3624
4-F
Ac
5-indolyl


3625
4-F
Ac
6-indolyl


3626
4-F
Ac
3-indazolyl


3627
4-F
Ac
5-indazolyl


3628
4-F
Ac
6-indazolyl


3629
4-F
Ac
2-imidazolyl


3630
4-F
Ac
3-isoxazoyl


3631
4-F
Ac
3-pyrazolyl


3632
4-F
Ac
2-thiadiazolyl


3633
4-F
Ac
2-thiazolyl


3634
4-F
Ac
5-Ac-4-Me-2-thiazolyl


3635
4-F
Ac
5-tetrazolyl


3636
4-F
Ac
2-benzimidazolyl


3637
4-F
Ac
5-benzimidazolyl


3638
4-F
Ac
2-benzothiazolyl


3639
4-F
Ac
5-benzothiazolyl


3640
4-F
Ac
2-benzoxazolyl


3641
4-F
Ac
5-benzoxazolyl


3642
4-F
Ac
1-adamantyl


3643
4-F
Ac
2-adamantyl


3644
4-F
Ac
i-Pr


3645
4-F
Ac
t-Bu


3646
4-F
Ac
c-Hex


3647
4-F
Ac
CH2CH2OMe


3648
4-F
Ac
CH2CONH2


3649
4-F
Ac
CH2CO2Me


3650
4-F
Ac
CH(CH2Ph)CO2Me


3651
4-F
Ac
CH2CH2NMe2


3652
4-F
Ac
benzyl


3653
4-F
Ac
phenethyl


3654
4-F
Ac
2-(morpholin-1-yl)-Et


3655
4-F
COtBu
Ph


3656
4-F
COtBu
3-CN—Ph


3657
4-F
COtBu
3-COMe—Ph


3658
4-F
COtBu
3-CO2Me—Ph


3659
4-F
COtBu
3-CONH2—Ph


3660
4-F
COtBu
3-CONHMe—Ph


3661
4-F
COtBu
3-F—Ph


3662
4-F
COtBu
3-Cl—Ph


3663
4-F
COtBu
3-Br—Ph


3664
4-F
COtBu
3-SO2NH2—Ph


3665
4-F
COtBu
3-SO2NHMe—Ph


3666
4-F
COtBu
3-CF3—Ph


3667
4-F
COtBu
3-OMe—Ph


3668
4-F
COtBu
3-SMe—Ph


3669
4-F
COtBu
3-SOMe—Ph


3670
4-F
COtBu
3-SO2Me—Ph


3671
4-F
COtBu
3-OH—Ph


3672
4-F
COtBu
3-CH2OH—Ph


3673
4-F
COtBu
3-CHOHMe—Ph


3674
4-F
COtBu
3-COH(Me)2—Ph


3675
4-F
COtBu
3-Me—Ph


3676
4-F
COtBu
3-Et—Ph


3677
4-F
COtBu
3-iPr—Ph


3678
4-F
COtBu
3-tBu—Ph


3679
4-F
COtBu
3-CH2CO2Me—Ph


3680
4-F
COtBu
3-(1-piperidinyl)—Ph


3681
4-F
COtBu
3-(1-pyrrolidinyl)-Ph


3682
4-F
COtBu
3-(2-imidazolyl)-Ph


3683
4-F
COtBu
3-(1-imidazolyl)-Ph


3684
4-F
COtBu
3-(2-thiazolyl)-Ph


3685
4-F
COtBu
3-(3-pyrazolyl)-Ph


3686
4-F
COtBu
3-(1-pyrazolyl)-Ph


3687
4-F
COtBu
3-(5-Me-1-tetrazolyl)-Ph


3688
4-F
COtBu
3-(1-Me-5-tetrazolyl)-Ph


3689
4-F
COtBu
3-(2-pyridyl)-Ph


3690
4-F
COtBu
3-(2-thienyl)-Ph


3691
4-F
COtBu
3-(2-furanyl)-Ph


3692
4-F
COtBu
4-CN—Ph


3693
4-F
COtBu
4-COMe—Ph


3694
4-F
COtBu
4-CO2Me—Ph


3695
4-F
COtBu
4-CONH2—Ph


3696
4-F
COtBu
4-CONHMe—Ph


3697
4-F
COtBu
4-CONHPh—Ph


3698
4-F
COtBu
4-F—Ph


3699
4-F
COtBu
4-Cl—Ph


3700
4-F
COtBu
4-Br—Ph


3701
4-F
COtBu
4-SO2NH2—Ph


3702
4-F
COtBu
4-SO2NHMe—Ph


3703
4-F
COtBu
4-CF3—Ph


3704
4-F
COtBu
4-ONe—Ph


3705
4-F
COtBu
4-SMe—Ph


3706
4-F
COtBu
4-SOMe—Ph


3707
4-F
COtBu
4-SO2Me—Ph


3708
4-F
COtBu
4-OH—Ph


3709
4-F
COtBu
4-CH2OH—Ph


3710
4-F
COtBu
4-CHOHMe—Ph


3711
4-F
COtBu
4-COH(Me)2—Ph


3712
4-F
COtBu
4-Me—Ph


3713
4-F
COtBu
4-Et—Ph


3714
4-F
COtBu
4-iPr—Ph


3715
4-F
COtBu
4-tBu—Ph


3716
4-F
COtBu
4-CH2CO2Me—Ph


3717
4-F
COtBu
4-(1-piperidinyl)-Ph


3718
4-F
COtBu
4-(1-pyrrolidinyl)-Ph


3719
4-F
COtBu
4-(2-imidazolyl)-Ph


3720
4-F
COtBu
4-(1-imidazolyl)-Ph


3721
4-F
COtBu
4-(2-thiazolyl)-Ph


3722
4-F
COtBu
4-(3-pyrazolyl)-Ph


3723
4-F
COtBu
4-(1-pyrazolyl)-Ph


3724
4-F
COtBu
4-(5-Me-1-tetrazolyl)—Ph


3725
4-F
COtBu
4-(1-Me-5-tetrazolyl)-Ph


3726
4-F
COtBu
4-(2-pyridyl)-Ph


3727
4-F
COtBu
4-(2-thienyl)-Ph


3728
4-F
COtBu
4-(2-furanyl)-Ph


3729
4-F
COtBu
2-CN—Ph


3730
4-F
COtBu
2-COMe—Ph


3731
4-F
COtBu
2-CO2Me—Ph


3732
4-F
COtBu
2-CONH2—Ph


3733
4-F
COtBu
2-CONHNe—Ph


3734
4-F
COtBu
2-F—Ph


3735
4-F
COtBu
2-Cl—Ph


3736
4-F
COtBu
2-Br—Ph


3737
4-F
COtBu
2-SO2NH2—Ph


3738
4-F
COtBu
2-SO2NHMe—Ph


3739
4-F
COtBu
2-CF3—Ph


3740
4-F
COtBu
2-ONe—Ph


3741
4-F
COtBu
2-SMe—Ph


3742
4-F
COtBu
2-SOMe—Ph


3743
4-F
COtBu
2-SO2Me—Ph


3744
4-F
COtBu
2-OH—Ph


3745
4-F
COtBu
2-CH2OH—Ph


3746
4-F
COtBu
2-CHOHMe—Ph


3747
4-F
COtBu
2-COH(Me)2—Ph


3748
4-F
COtBu
2-Me—Ph


3749
4-F
COtBu
2-Et—Ph


3750
4-F
COtBu
2-iPr—Ph


3751
4-F
COtBu
2-tBu—Ph


3752
4-F
COtBu
2-CH2CO2Me—Ph


3753
4-F
COtBu
2-(1-piperidinyl)-Ph


3754
4-F
COtBu
2-(1-pyrrolidinyl)-Ph


3755
4-F
COtBu
2-(2-imidazolyl)-Ph


3756
4-F
COtBu
2-(1-imidazolyl)-Ph


3757
4-F
COtBu
2-(2-thiazolyl)-Ph


3758
4-F
COtBu
2-(3-pyrazolyl)-Ph


3759
4-F
COtBu
2-(1-pyrazolyl)-Ph


3760
4-F
COtBu
2-(5-Me-1-tetrazolyl)-Ph


3761
4-F
COtBu
2-(1-Me-5-tetrazolyl)-Ph


3762
4-F
COtBu
2-(2-pyridyl)-Ph


3763
4-F
COtBu
2-(2-thienyl)-Ph


3764
4-F
COtBu
2-(2-furanyl)-Ph


3765
4-F
COtBu
2,4-diF—Ph


3766
4-F
COtBu
2,5-diF—Ph


3767
4-F
COtBu
2,6-diF—Ph


3768
4-F
COtBu
3,4-diF—Ph


3769
4-F
COtBu
3,5-diF—Ph


3770
4-F
COtBu
2,4-diCl—Ph


3771
4-F
COtBu
2,5-diCl—Ph


3772
4-F
COtBu
2,6-diCl—Ph


3773
4-F
COtBu
3,4-diCl—Ph


3774
4-F
COtBu
3,5-diCl—Ph


3776
4-F
COtBu
3,5-diCF3—Ph


3778
4-F
COtBu
5-Cl-2-Me—Ph


3779
4-F
COtBu
2-F-5-Me—Ph


3780
4-F
COtBu
3-F-5-morpholino-Ph


3781
4-F
COtBu
3,4-OCH2O—Ph


3782
4-F
COtBu
3,4-OCH2CH2O—Ph


3783
4-F
COtBu
2-MeO-5-CONH2—Ph


3784
4-F
COtBu
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


3785
4-F
COtBu
2-MeO-5-(1-Me-5-tetrazolyl)-Ph


3786
4-F
COtBu
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


3787
4-F
COtBu
1-naphthyl


3788
4-F
COtBu
2-naphthyl


3789
4-F
COtBu
2-thienyl


3790
4-F
COtEu
3-thienyl


3791
4-F
COtBu
2-furanyl


3792
4-F
COtBu
3-furanyl


3793
4-F
COtBu
2-pyridyl


3794
4-F
COtBu
3-pyridyl


3795
4-F
COtBu
4-pyridyl


3796
4-F
COtBu
2-indolyl


3797
4-F
COtBu
3-indolyl


3798
4-F
COtBu
5-indolyl


3799
4-F
COtBu
6-indolyl


3800
4-F
COtBu
3-indazolyl


3801
4-F
COtBu
5-indazolyl


3802
4-F
COtBu
6-indazolyl


3803
4-F
COtBu
2-imidazolyl


3804
4-F
COtBu
3-isoxazoyl


3805
4-F
COtBu
3-pyrazolyl


3806
4-F
COtBu
2-thiadiazolyl


3807
4-F
COtBu
2-thiazolyl


3808
4-F
COtBu
5-Ac-4-Me-2-thiazolyl


3809
4-F
COtBu
5-tetrazolyl


3810
4-F
COtBu
2-benzimidazolyl


3811
4-F
COtBu
5-benzimidazolyl


3812
4-F
COtBu
2-benzothiazolyl


3813
4-F
COtBu
5-benzothiazolyl


3814
4-F
COtBu
2-benzoxazolyl


3815
4-F
COtBu
5-benzoxazolyl


3816
4-F
COtBu
1-adamantyl


3817
4-F
COtBu
2-adamantyl


3818
4-F
COtBu
i-Pr


3819
4-F
COtBu
t-Bu


3820
4-F
COtBu
c-Hex


3821
4-F
COtBu
CH2CH2OMe


3822
4-F
COtBu
CH2CONH2


3823
4-F
COtBu
CH2CO2Me


3824
4-F
COtBu
CH(CH2Ph)CO2Me


3825
4-F
COtBu
CH2CH2NMe2


3826
4-F
COtBu
benzyl


3827
4-F
COtBu
phenethyl


3828
4-F
COtBu
2-(morpholin-1-yl)-Et


3829
4-F
SO2Me
Ph


3830
4-F
SO2Me
3-CN—Ph


3831
4-F
SO2Me
3-COMe—Ph


3832
4-F
SO2Me
3-CO2Me—Ph


3833
4-F
SO2Me
3-CONH2—Ph


3834
4-F
SO2Me
3-CONHMe—Ph


3835
4-F
SO2Me
3-F—Ph


3836
4-F
SO2Me
3-Cl—Ph


3837
4-F
SO2Me
3-Br—Ph


3838
4-F
SO2Me
3-SO2NH2—Ph


3839
4-F
SO2Me
3-SO2NHMe—Ph


3840
4-F
SO2Me
3-CF3—Ph


3841
4-F
SO2Me
3-OMe—Ph


3842
4-F
SO2Me
3-SMe—Ph


3843
4-F
SO2Me
3-SOMe—Ph


3844
4-F
SO2Me
3-SO2Me—Ph


3845
4-F
SO2Me
3-OH—Ph


3846
4-F
SO2Me
3-CH2OH—Ph


3847
4-F
SO2Me
3-CHOHMe—Ph


3848
4-F
SO2Me
3-COH(Me)2—Ph


3849
4-F
SO2Me
3-Me—Ph


3850
4-F
SO2Me
3-Et—Ph


3851
4-F
SO2Me
3-iPr—Ph


3852
4-F
SO2Me
3-tBu—Ph


3853
4-F
SO2Me
3-CH2CO2Me—Ph


3854
4-F
SO2Me
3-(1-piperidinyl)-Ph


3855
4-F
SO2Me
3-(1-pyrrolidinyl)-Ph


3856
4-F
SO2Me
3-(2-imidazolyl)-Ph


3857
4-F
SO2Me
3-(1-imidazolyl)-Ph


3858
4-F
SO2Me
3-(2-thiazolyl)-Ph


3859
4-F
SO2Me
3-(3-pyrazolyl)-Ph


3860
4-F
SO2Me
3-(1-pyrazolyl)-Ph


3861
4-F
SO2Me
3-(5-Me-1-tetrazolyl)-Ph


3862
4-F
SO2Me
3-(1-Me-5-tetrazolyl)-Ph


3863
4-F
SO2Me
3-(2-pyridyl)-Ph


3864
4-F
SO2Me
3-(2-thienyl)-Ph


3865
4-F
SO2Me
3-(2-furanyl)-Ph


3866
4-F
SO2Me
4-CN—Ph


3867
4-F
SO2Me
4-COMe—Ph


3868
4-F
SO2Me
4-CO2Me—Ph


3869
4-F
SO2Me
4-CONH2—Ph


3870
4-F
SO2Me
4-CONHMe—Ph


3871
4-F
SO2Me
4-CONHPh—Ph


3872
4-F
SO2Me
4-F—Ph


3873
4-F
SO2Me
4-Cl—Ph


3874
4-F
SO2Me
4-Br—Ph


3875
4-F
SO2Me
4-SO2NH2—Ph


3876
4-F
SO2Me
4-SO2NHMe—Ph


3877
4-F
SO2Me
4-CF3—Ph


3878
4-F
SO2Me
4-OMe—Ph


3879
4-F
SO2Me
4-SMe—Ph


3880
4-F
SO2Me
4-SOMe—Ph


3881
4-F
SO2Me
4-SO2Me—Ph


3882
4-F
SO2Me
4-OH—Ph


3883
4-F
SO2Me
4-CH2OH—Ph


3884
4-F
SO2Me
4-CHOliNe—Ph


3885
4-F
SO2Me
4-COH(Me)2—Ph


3886
4-F
SO2Me
4-Me—Ph


3887
4-F
SO2Me
4-Et—Ph


3888
4-F
SO2Me
4-iPr—Ph


3889
4-F
SO2Me
4-tBu—Ph


3890
4-F
SO2Me
4-CH2CO2Me—Ph


3891
4-F
SO2Me
4-(1-piperidinyl)-Ph


3892
4-F
SO2Me
4-(1-pyrrolidinyl)-Ph


3893
4-F
SO2Me
4-(2-imidazolyl)-Ph


3894
4-F
SO2Me
4-(1-imidazolyl)-Ph


3895
4-F
SO2Me
4-(2-thiazolyl)-Ph


3896
4-F
SO2Me
4-(3-pyrazolyl)-Ph


3897
4-F
SO2Me
4-(1-pyrazolyl)-Ph


3898
4-F
SO2Me
4-(5-Me-1-tetrazolyl)-Ph


3899
4-F
SO2Me
4-(1-Me-5-tetrazolyl)-Ph


3900
4-F
SO2Me
4-(2-pyridyl)-Ph


3901
4-F
SO2Me
4-(2-thienyl)-Ph


3902
4-F
SO2Me
4-(2-furanyl)-Ph


3903
4-F
SO2Me
2-CN—Ph


3904
4-F
SO2Me
2-COMe—Ph


3905
4-F
SO2Me
2-CO2Me—Ph


3906
4-F
SO2Me
2-CONH2—Ph


3907
4-F
SO2Me
2-CONHMe—Ph


3908
4-F
SO2Me
2-F—Ph


3909
4-F
SO2Me
2-Cl—Ph


3910
4-F
SO2Me
2-Br—Ph


3911
4-F
SO2Me
2-SO2NH2—Ph


3912
4-F
SO2Me
2-SO2NHMe—Ph


3913
4-F
SO2Me
2-CF3—Ph


3914
4-F
SO2Me
2-OMe—Ph


3915
4-F
SO2Me
2-SMe—Ph


3916
4-F
SO2Me
2-SOMe—Ph


3917
4-F
SO2Me
2-SO2Me—Ph


3918
4-F
SO2Me
2-OH—Ph


3919
4-F
SO2Me
2-CH2OH—Ph


3920
4-F
SO2Me
2-CHOHIMe—Ph


3921
4-F
SO2Me
2-COH(Me)2—Ph


3922
4-F
SO2Me
2-Me—Ph


3923
4-F
SO2Me
2-Et—Ph


3924
4-F
SO2Me
2-iPr—Ph


3925
4-F
SO2Me
2-tBu—Ph


3926
4-F
SO2Me
2-CH2CO2Me—Ph


3927
4-F
SO2Me
2-(1-piperidinyl)-Ph


3928
4-F
SO2Me
2-(1-pyrrolidinyl)-Ph


3929
4-F
SO2Me
2-(2-imidazolyl)-Ph


3930
4-F
SO2Me
2-(1-imidazolyl)-Ph


3931
4-F
SO2Me
2-(2-thiazolyl)-Ph


3932
4-F
SO2Me
2-(3-pyrazolyl)-Ph


3933
4-F
SO2Me
2-(1-pyrazolyl)-Ph


3934
4-F
SO2Me
2-(5-Me-1-tetrazolyl)-Ph


3935
4-F
SO2Me
2-(1-Me-5-tetrazolyl)-Ph


3936
4-F
SO2Me
2-(2-pyridyl)-Ph


3937
4-F
SO2Me
2-(2-thienyl)-Ph


3938
4-F
SO2Me
2-(2-furanyl)-Ph


3939
4-F
SO2Me
2,4-diF—Ph


3940
4-F
SO2Me
2,5-diF—Ph


3941
4-F
SO2Me
2,6-diF—Ph


3942
4-F
SO2Me
3,4-diF—Ph


3943
4-F
SO2Me
3,5-diF—Ph


3944
4-F
SO2Me
2,4-diCl—Ph


3945
4-F
SO2Me
2,5-diCl—Ph


3946
4-F
SO2Me
2,6-diCl—Ph


3947
4-F
SO2Me
3,4-diCl—Ph


3948
4-F
SO2Me
3,5-diCl—Ph


3949
4-F
SO2Me
3,4-diCF3—Ph


3950
4-F
SO2Me
3,5-diCF3—Ph


3951
4-F
SO2Me
5-Cl-2-MeO—Ph


3952
4-F
SO2Me
5-Cl-2-Me—Ph


3953
4-F
SO2Me
2-F-5-Me—Ph


3954
4-F
SO2Me
3-F-5-morpholino-Ph


3955
4-F
SO2Me
3,4-OCH2O—Ph


3956
4-F
SO2Me
3,4-OCH2CH2O—Ph


3957
4-F
SO2Me
2-MeO-5-CONH2—Ph


3958
4-F
SO2Me
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


3959
4-F
SO2Me
2-MeO-5-(1-Me-5-tetrazolyl)-Ph


3960
4-F
SO2Me
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


3961
4-F
SO2Me
1-naphthyl


3962
4-F
SO2Me
2-naphthyl


3963
4-F
SO2Me
2-thienyl


3964
4-F
SO2Me
3-thienyl


3965
4-F
SO2Me
2-furanyl


3966
4-F
SO2Me
3-furanyl


3967
4-F
SO2Me
2-pyridyl


3968
4-F
SO2Me
3-pyridyl


3969
4-F
SO2Me
4-pyridyl


3970
4-F
SO2Me
2-indolyl


3971
4-F
SO2Me
3-indolyl


3972
4-F
SO2Me
5-indolyl


3973
4-F
SO2Me
6-indolyl


3974
4-F
SO2Me
3-indazolyl


3975
4-F
SO2Me
5-indazolyl


3976
4-F
SO2Me
6-indazolyl


3977
4-F
SO2Me
2-imidazolyl


3978
4-F
SO2Me
3-isoxazoyl


3979
4-F
SO2Me
3-pyrazolyl


3980
4-F
SO2Me
2-thiadiazolyl


3981
4-F
SO2Me
2-thiazolyl


3982
4-F
SO2Me
5-Ac-4-Me-2-thiazolyl


3983
4-F
SO2Me
5-tetrazolyl


3984
4-F
SO2Me
2-benzimidazolyl


3985
4-F
SO2Me
5-benzimidazolyl


3986
4-F
SO2Me
2-benzothiazolyl


3987
4-F
SO2Me
5-benzothiazolyl


3988
4-F
SO2Me
2-benzoxazolyl


3989
4-F
SO2Me
5-benzoxazolyl


3990
4-F
SO2Me
1-adarnantyl


3991
4-F
SO2Me
2-adamantyl


3992
4-F
SO2Me
i-Pr


3993
4-F
SO2Me
t-Bu


3994
4-F
SO2Me
c-Hex


3995
4-F
SO2Me
CH2CH2OMe


3996
4-F
SO2Me
CH2CONH2


3997
4-F
SO2Me
CH2CO2Me


3998
4-F
SO2Me
CH(CH2Ph)CO2Me


3999
4-F
SO2Me
CH2CH2NMe2


4000
4-F
SO2Me
benzyl


4001
4-F
SO2Me
phenethyl


4002
4-F
SO2Me
2-(morpholin-1-yl)-Et


4003
4-F
CH2COMe
Ph


4004
4-F
CH2COMe
3-CN—Ph


4005
4-F
CH2COMe
3-COMe—Ph


4006
4-F
CH2COMe
3-CO2Me—Ph


4007
4-F
CH2COMe
3-CONH2—Ph


4008
4-F
CH2COMe
3-CONHMe—Ph


4009
4-F
CH2COMe
3-F—Ph


4010
4-F
CH2COMe
3-Cl—Ph


4011
4-F
CH2COMe
3-Br—Ph


4012
4-F
CH2COMe
3-SO2NH2—Ph


4013
4-F
CH2COMe
3-SO2NHMe—Ph


4014
4-F
CH2COMe
3-CF3—Ph


4015
4-F
CH2COMe
3-OMe—Ph


4016
4-F
CH2COMe
3-SMe—Ph


4017
4-F
CH2COMe
3-SOMe—Ph


4018
4-F
CH2COMe
3-SO2Me—Ph


4019
4-F
CH2COMe
3-OH—Ph


4020
4-F
CH2COMe
3-CH2OH—Ph


4021
4-F
CH2COMe
3-CHOHMe—Ph


4022
4-F
CH2COMe
3-COH(Me)2—Ph


4023
4-F
CH2COMe
3-Me—Ph


4024
4-F
CH2COMe
3-Et—Ph


4025
4-F
CH2COMe
3-iPr—Ph


4026
4-F
CH2COMe
3-tBu—Ph


4027
4-F
CH2COMe
3-CH2CO2Me—Ph


4028
4-F
CH2COMe
3-(1-piperidinyl)-Ph


4029
4-F
CH2COMe
3-(1-pyrrolidinyl)-Ph


4030
4-F
CH2COMe
3-(2-imidazolyl)-Ph


4031
4-F
CH2COMe
3-(1-imidazolyi)—Ph


4032
4-F
CH2COMe
3-(2-thiazolyl)-Ph


4033
4-F
CH2COMe
3-(3-pyrazolyl)-Ph


4034
4-F
CH2COMe
3-(1-pyrazolyl)-Ph


4035
4-F
CH2COMe
3-(5-Me-1-tetrazolyl)-Ph


4036
4-F
CH2COMe
3-(1-Me-5-tetrazolyl)-Ph


4037
4-F
CH2COMe
3-(2-pyridyl)-Ph


4038
4-F
CH2COMe
3-(2-thienyl)-Ph


4039
4-F
CH2COMe
3-(2-furanyl)-Ph


4040
4-F
CH2COMe
4-CN—Ph


4041
4-F
CH2COMe
4-COMe—Ph


4042
4-F
CH2COMe
4-CO2Me—Ph


4043
4-F
CH2COMe
4-CONH2—Ph


4044
4-F
CH2COMe
4-CONHMe—Ph


4045
4-F
CH2COMe
4-CONHPh—Ph


4046
4-F
CH2COMe
4-F—Ph


4047
4-F
CH2COMe
4-Cl—Ph


4048
4-F
CH2COMe
4-Br—Ph


4049
4-F
CH2COMe
4-SO2NH2—Ph


4050
4-F
CH2COMe
4-SO2NHMe—Ph


4051
4-F
CH2COMe
4-CF3—Ph


4052
4-F
CH2COMe
4-OMe—Ph


4053
4-F
CH2COMe
4-SMe—Ph


4054
4-F
CH2COMe
4-SOMe—Ph


4055
4-F
CH2COMe
4-SO2Me—Ph


4056
4-F
CH2COMe
4-OH—Ph


4057
4-F
CH2COMe
4-CH2OH—Ph


4058
4-F
CH2COMe
4-CHOHMe—Ph


4059
4-F
CH2COMe
4-COH(Me)2—Ph


4060
4-F
CH2COMe
4-Me—Ph


4061
4-F
CH2COMe
4-Et—Ph


4062
4-F
CH2COMe
4-iPr—Ph


4063
4-F
CH2COMe
4-4-tBu—Ph


4064
4-F
CH2COMe
4-CH2CO2Me—Ph


4065
4-F
CH2COMe
4-(1-piperidinyl)-Ph


4066
4-F
CH2COMe
4-(1-pyrrolidinyl)-Ph


4067
4-F
CH2COMe
4-(2-imidazolyl)-Ph


4068
4-F
CH2COMe
4-(1-irnidazolyl)-Ph


4069
4-F
CH2COMe
4-(2-thiazolyl)-Ph


4070
4-F
CH2COMe
4-(3-pyrazolyl)-Ph


4071
4-F
CH2COMe
4-(1-pyrazolyl)-Ph


4072
4-F
CH2COMe
4-(5-Me-1-tetrazolyl)-Ph


4073
4-F
CH2COMe
4-(1-Me-5-tetrazolyl)-Ph


4074
4-F
CH2COMe
4-(2-pyridyl)-Ph


4075
4-F
CH2COMe
4-(2-thienyl)-Ph


4076
4-F
CH2COMe
4-(2-furanyl)-Ph


4077
4-F
CH2COMe
2-CN—Ph


4078
4-F
CH2COMe
2-COMe—Ph


4079
4-F
CH2COMe
2-CO2Me—Ph


4080
4-F
CH2COMe
2-CONH2—Ph


4081
4-F
CH2COMe
2-CONHMe—Ph


4082
4-F
CH2COMe
2-F—Ph


4083
4-F
CH2COMe
2-Cl—Ph


4084
4-F
CH2COMe
2-Br—Ph


4085
4-F
CH2COMe
2-SO2NH2—Ph


4086
4-F
CH2COMe
2-SO2NHMe—Ph


4087
4-F
CH2COMe
2-CF3—Ph


4088
4-F
CH2COMe
2-OMe—Ph


4089
4-F
CH2COMe
2-SMe—Ph


4090
4-F
CH2COMe
2-SOMe—Ph


4091
4-F
CH2COMe
2-SO2Me—Ph


4092
4-F
CH2COMe
2-OH—Ph


4093
4-F
CH2COMe
2-CH2OH—Ph


4094
4-F
CH2COMe
2-CHOHMe—Ph


4095
4-F
CH2COMe
2-COH(Me)2—Ph


4096
4-F
CH2COMe
2-Me—Ph


4097
4-F
CH2COMe
2-Et—Ph


4098
4-F
CH2COMe
2-iPr—Ph


4099
4-F
CH2COMe
2-tBu—Ph


4100
4-F
CH2COMe
2-CH2CO2Me—Ph


4101
4-F
CH2COMe
2-(1-piperidinyl)-Ph


4102
4-F
CH2COMe
2-(1-pyrrolidinyl)-Ph


4103
4-F
CH2COMe
2-(2-imidazolyl)-Ph


4104
4-F
CH2COMe
2-(1-imidazolyl)-Ph


4105
4-F
CH2COMe
2-(2-thiazolyl)-Ph


4106
4-F
CH2COMe
2-(3-pyrazolyl)-Ph


4107
4-F
CH2COMe
2-(1-pyrazolyl)-Ph


4108
4-F
CH2COMe
2-(5-Me-1-tetrazolyl)-Ph


4109
4-F
CH2COMe
2-(1-Me-5-tetrazolyl)-Ph


4110
4-F
CH2COMe
2-(2-pyridyl)-Ph


4111
4-F
CH2COMe
2-(2-thienyl)-Ph


4112
4-F
CH2COMe
2-(2-furanyl)-Ph


4113
4-F
CH2COMe
2,4-diF—Ph


4114
4-F
CH2COMe
2,5-diF—Ph


4115
4-F
CH2COMe
2,6-diF—Ph


4116
4-F
CH2COMe
3,4-diF—Ph


4117
4-F
CH2COMe
3,5-diF—Ph


4118
4-F
CH2COMe
2,4-diCl—Ph


4119
4-F
CH2COMe
2,5-diCl—Ph


4120
4-F
CH2COMe
2,6-diCl—Ph


4121
4-F
CH2COMe
3,4-diCl—Ph


4122
4-F
CH2COMe
3,5-diCl—Ph


4123
4-F
CH2COMe
3,4-diCF3—Ph


4124
4-F
CH2COMe
3,5-diCF3—Ph


4125
4-F
CH2COMe
5-Cl-2-MeO—Ph


4126
4-F
CH2COMe
5-Cl-2-Me—Ph


4127
4-F
CH2COMe
2-F-5-Me—Ph


4128
4-F
CH2COMe
3-F-5-morpholino-Ph


4129
4-F
CH2COMe
3,4-OCH2O—Ph


4130
4-F
CH2COMe
3,4-OCH2CH2O—Ph


4131
4-F
CH2COMe
2-MeO-5-CONH2—Ph


4132
4-F
CH2COMe
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


4133
4-F
CH2COMe
2-MeO-5-(1-Me-5-tetrazolyl)-Ph


4134
4-F
CH2COMe
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


4135
4-F
CH2COMe
1-naphthyl


4136
4-F
CH2COMe
2-naphthyl


4137
4-F
CH2COMe
2-thienyl


4138
4-F
CH2COMe
3-thienyl


4139
4-F
CH2COMe
2-furanyl


4140
4-F
CH2COMe
3-furanyl


4141
4-F
CH2COMe
2-pyridyl


4142
4-F
CH2COMe
3-pyridyl


4143
4-F
CH2COMe
4-pyridyl


4144
4-F
CH2COMe
2-indolyl


4145
4-F
CH2COMe
3-indolyl


4146
4-F
CH2COMe
5-indolyl


4147
4-F
CH2COMe
6-indolyl


4148
4-F
CH2COMe
3-indazolyl


4149
4-F
CH2COMe
5-indazolyl


4150
4-F
CH2COMe
6-indazolyl


4151
4-F
CH2COMe
2-imidazolyl


4152
4-F
CH2COMe
3-isoxazoyl


4153
4-F
CH2COMe
3-pyrazolyl


4154
4-F
CH2COMe
2-thiadiazolyl


4155
4-F
CH2COMe
2-thiazolyl


4156
4-F
CH2COMe
5-Ac-4-Me-2-thiazolyl


4157
4-F
CH2COMe
5-tetrazolyl


4158
4-F
CH2COMe
2-benzimidazolyl


4159
4-F
CH2COMe
5-benzimidazolyl


4160
4-F
CH2COMe
2-benzothiazolyl


4161
4-F
CH2COMe
5-benzothiazolyl


4162
4-F
CH2COMe
2-benzoxazolyl


4163
4-F
CH2COMe
5-benzoxazolyl


4164
4-F
CH2COMe
1-adamantyl


4165
4-F
CH2COMe
2-adamantyl


4166
4-F
CH2COMe
i-Pr


4167
4-F
CH2COMe
t-Bu


4168
4-F
CH2COMe
c-Hex


4169
4-F
CH2COMe
CH2CH2OMe


4170
4-F
CH2COMe
CH2CONH2


4171
4-F
CH2COMe
CH2CO2Me


4172
4-F
CH2COMe
CH(CH2Ph)CO2Me


4173
4-F
CH2COMe
CH2CH2NMe2


4174
4-F
CH2COMe
benzyl


4175
4-F
CH2COMe
phenethyl


4176
4-F
CH2COMe
2-(morpholin-1-yl)-Et


4177
4-Cl
H
Ph


4178
4-Cl
H
3-CN—Ph


4179
4-Cl
H
3-COMe—Ph


4180
4-Cl
H
3-CO2Me—Ph


4181
4-Cl
H
3-CONH2—Ph


4182
4-Cl
H
3-CONHMe—Ph


4183
4-Cl
H
3-F—Ph


4184
4-Cl
H
3-Cl—Ph


4185
4-Cl
H
3-Br—Ph


4186
4-Cl
H
3-SO2NH2—Ph


4187
4-Cl
H
3-SO2NHMe—Ph


4188
4-Cl
H
3-CF3—Ph


4189
4-Cl
H
3-OMe—Ph


4190
4-Cl
H
3-SMe—Ph


4191
4-Cl
H
3-SOMe—Ph


4192
4-Cl
H
3-SO2Me—Ph


4193
4-Cl
H
3-OH—Ph


4194
4-Cl
H
3-CH2OH—Ph


4195
4-Cl
H
3-CHOHMe—Ph


4196
4-Cl
H
3-COH(Me)2—Ph


4197
4-Cl
H
3-Me—Ph


4198
4-Cl
H
3-Et—Ph


4199
4-Cl
H
3-iPr—Ph


4200
4-Cl
H
3-tBu—Ph


4201
4-Cl
H
3-CH2CO2Me—Ph


4202
4-Cl
H
3-(1-piperidinyl)-Ph


4203
4-Cl
H
3-(1-pyrrolidinyl)-Ph


4204
4-Cl
H
3-(2-imidazolyl)-Ph


4205
4-Cl
H
3-(1-imidazolyl)-Ph


4206
4-Cl
H
3-(2-thiazolyl)-Ph


4207
4-Cl
H
3-(3-pyrazolyl)-Ph


4208
4-Cl
H
3-(1-pyrazolyl)-Ph


4209
4-Cl
H
3-(5-Me-1-tetrazolyl)-Ph


4210
4-Cl
H
3-(1-Me-5-tetrazolyl)-Ph


4211
4-Cl
H
3-(2-pyridyl)-Ph


4212
4-Cl
H
3-(2-thienyl)-Ph


4213
4-Cl
H
3-(2-furanyl)-Ph


4214
4-Cl
H
4-CN—Ph


4215
4-Cl
H
4-COMe—Ph


4216
4-Cl
H
4-CO2Me—Ph


4217
4-Cl
H
4-CONH2—Ph


4218
4-Cl
H
4-CONHMe—Ph


4219
4-Cl
H
4-CONHPh—Ph


4220
4-Cl
H
4-F—Ph


4221
4-Cl
H
4-Cl—Ph


4222
4-Cl
H
4-Br—Ph


4223
4-Cl
H
4-SO2NH2—Ph


4224
4-Cl
H
4-SO2NHMe—Ph


4225
4-Cl
H
4-CF3—Ph


4226
4-Cl
H
4-OMe—Ph


4227
4-Cl
H
4-SMe—Ph


4228
4-Cl
H
4-SOMe—Ph


4229
4-Cl
H
4-SO2Me—Ph


4230
4-Cl
H
4-OH—Ph


4231
4-Cl
H
4-CH2OH—Ph


4232
4-Cl
H
4-CHOHMe—Ph


4233
4-Cl
H
4-COH(Me)2—Ph


4234
4-Cl
H
4-Me—Ph


4235
4-Cl
H
4-Et—Ph


4236
4-Cl
H
4-iPr—Ph


4237
4-Cl
H
4-tBu—Ph


4238
4-Cl
H
4-CH2CO2Me—Ph


4239
4-Cl
H
4-(1-piperidinyl)-Ph


4240
4-Cl
H
4-(1-pyrrolidinyl)-Ph


4241
4-Cl
H
4-(2-imidazolyl)-Ph


4242
4-Cl
H
4-(1-imidazolyl)-Ph


4243
4-Cl
H
4-(2-thiazolyl)-Ph


4244
4-Cl
H
4-(3-pyrazolyl)-Ph


4245
4-Cl
H
4-(1-pyrazolyl)-Ph


4246
4-Cl
H
4-(5-Me-1-tetrazolyl)-Ph


4247
4-Cl
H
4-(1-Me-5-tetrazolyl)—Ph


4248
4-Cl
H
4-(2-pyridyl)-Ph


4249
4-Cl
H
4-(2-thienyl)-Ph


4250
4-Cl
H
4-(2-furanyl)-Ph


4251
4-Cl
H
2-CN—Ph


4252
4-Cl
H
2-COMe—Ph


4253
4-Cl
H
2-CO2Me—Ph


4254
4-Cl
H
2-CONH2—Ph


4255
4-Cl
H
2-CONHMe—Ph


4256
4-Cl
H
2-F—Ph


4257
4-Cl
H
2-Cl—Ph


4258
4-Cl
H
2-Br—Ph


4259
4-Cl
H
2-SO2NH2—Ph


4260
4-Cl
H
2-SO2NHMe—Ph


4261
4-Cl
H
2-CF3—Ph


4262
4-Cl
H
2-OMe—Ph


4263
4-Cl
H
2-SMe—Ph


4264
4-Cl
H
2-SOMe—Ph


4265
4-Cl
H
2-SO2Me—Ph


4266
4-Cl
H
2-OH—Ph


4267
4-Cl
H
2-CH2OH—Ph


4268
4-Cl
H
2-CHOHMe—Ph


4269
4-Cl
H
2-COH(Me)2-Ph


4270
4-Cl
H
2-Me—Ph


4271
4-Cl
H
2-Et—Ph


4272
4-Cl
H
2-iPr—Ph


4273
4-Cl
H
2-tBu—Ph


4274
4-Cl
H
2-CH2CO2Me—Ph


4275
4-Cl
H
2-(1-piperidinyl)-Ph


4276
4-Cl
H
2-(1-pyrrolidinyl)-Ph


4277
4-Cl
H
2-(2-imidazolyl)-Ph


4278
4-Cl
H
2-(1-imidazolyl)-Ph


4279
4-Cl
H
2-(2-thiazolyl)-Ph


4280
4-Cl
H
2-(3-pyrazolyl)-Ph


4281
4-Cl
H
2-(1-pyrazolyl)-Ph


4282
4-Cl
H
2-(5-Me-1-tetrazolyl)-Ph


4283
4-Cl
H
2-(1-Me-5-tetrazolyl)-Ph


4284
4-Cl
H
2-(2-pyridyl)-Ph


4285
4-Cl
H
2-(2-thienyl)-Ph


4286
4-Cl
H
2-(2-furanyl)-Ph


4287
4-Cl
H
2,4-diF—Ph


4288
4-Cl
H
2,5-diF—Ph


4289
4-Cl
H
2,6-diF—Ph


4290
4-Cl
H
3,4-diF—Ph


4291
4-Cl
H
3,5-diF—Ph


4292
4-Cl
H
2,4-diCl—Ph


4293
4-Cl
H
2,5-diCl—Ph


4294
4-Cl
H
2,6-diCl—Ph


4295
4-Cl
H
3,4-diCl—Ph


4296
4-Cl
H
3,5-diCl—Ph


4297
4-Cl
H
3,4-diCF3—Ph


4298
4-Cl
H
3,5-diCF3—Ph


4299
4-Cl
H
5-Cl-2-MeO—Ph


4300
4-Cl
H
5-Cl-2-Me—Ph


4301
4-Cl
H
2-F-5-Me—Ph


4302
4-Cl
H
3-F-5-morpholino-Ph


4303
4-Cl
H
3,4-OCH2O—Ph


4304
4-Cl
H
3,4-OCH2CH2O—Ph


4305
4-Cl
H
2-MeO-5-CONH2—Ph


4306
4-Cl
H
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


4307
4-Cl
H
2-MeO-5-(1-Me-5-tetrazolyl)-Ph


4308
4-Cl
H
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


4309
4-Cl
H
1-naphthyl


4310
4-Cl
H
2-napthyl


4311
4-Cl
H
2-thienyl


4312
4-Cl
H
3-thienyl


4313
4-Cl
H
2-furanyl


4314
4-Cl
H
3-furanyl


4315
4-Cl
H
2-pyridyl


4316
4-Cl
H
3-pyridyl


4317
4-Cl
H
4-pyridyl


4318
4-Cl
H
2-indolyl


4319
4-Cl
H
3-indolyl


4320
4-Cl
H
5-indolyl


4321
4-Cl
H
6-indolyl


4322
4-Cl
H
3-indazolyl


4323
4-Cl
H
5-indazolyl


4324
4-Cl
H
6-indazolyl


4325
4-Cl
H
2-imidazolyl


4326
4-Cl
H
3-isoxazoyl


4327
4-Cl
H
3-pyrazolyl


4328
4-Cl
H
2-thiadiazolyl


4329
4-Cl
H
2-thiazolyl


4330
4-Cl
H
5-Ac-4-Me-2-thiazolyl


4331
4-Cl
H
5-tetrazolyl


4332
4-Cl
H
2-benzimidazolyl


4333
4-Cl
H
5-benzimidazolyl


4334
4-Cl
H
2-benzothiazolyl


4335
4-Cl
H
5-benzothiazolyl


4336
4-Cl
H
2-benzoxazolyl


4337
4-Cl
H
5-benzoxazolyl


4338
4-Cl
H
1-adamantyl


4339
4-Cl
H
2-adamantyl


4340
4-Cl
H
i-Pr


4341
4-Cl
H
t-Bu


4342
4-Cl
H
c-Hex


4343
4-Cl
H
CH2CH2OMe


4344
4-Cl
H
CH2CONH2


4345
4-Cl
H
CH2CO2Me


4346
4-Cl
H
CH(CH2Ph)CO2Me


4347
4-Cl
H
CH2CH2NMe2


4348
4-Cl
H
benzyl


4349
4-Cl
H
phenethyl


4350
4-Cl
H
2-(morpholin-1-yl)-Et


4351
4-Cl
Me
Ph


4352
4-Cl
Me
3-CN—Ph


4353
4-Cl
Me
3-COMe—Ph


4354
4-Cl
Me
3-CO2Me—Ph


4355
4-Cl
Me
3-CONH2—Ph


4356
4-Cl
Me
3-CONHMe—Ph


4357
4-Cl
Me
3-F—Ph


4358
4-Cl
Me
3-Cl—Ph


4359
4-Cl
Me
3-Br—Ph


4360
4-Cl
Me
3-SO2NH2—Ph


4361
4-Cl
Me
3-SO2NHMe—Ph


4362
4-Cl
Me
3-CF3—Ph


4363
4-Cl
Me
3-OMe—Ph


4364
4-Cl
Me
3-SMe—Ph


4365
4-Cl
Me
3-SOMe—Ph


4366
4-Cl
Me
3-SO2Me—Ph


4367
4-Cl
Me
3-OH—Ph


4368
4-Cl
Me
3-CH2OH—Ph


4369
4-Cl
Me
3-CHOHMe—Ph


4370
4-Cl
Me
3-COH(Me)2—Ph


4371
4-Cl
Me
3-Me—Ph


4372
4-Cl
Me
3-Et—Ph


4373
4-Cl
Me
3-iPr—Ph


4374
4-Cl
Me
3-tBu—Ph


4375
4-Cl
Me
3-CH2CO2Me—Ph


4376
4-Cl
Me
3-(1-piperidinyl)-Ph


4377
4-Cl
Me
3-(1-pyrrolidinyl)-Ph


4378
4-Cl
Me
3-(2-irnidazolyl)-Ph


4379
4-Cl
Me
3-(1-imidazolyl)-Ph


4380
4-Cl
Me
3-(2-thiazolyl)-Ph


4381
4-Cl
Me
3-(3-pyrazolyl)-Ph


4382
4-Cl
Me
3-(1-pyrazolyl)-Ph


4383
4-Cl
Me
3-(5-Me-1-tetrazolyl)-Ph


4384
4-Cl
Me
3-(1-Me-5-tetrazolyl)-Ph


4385
4-Cl
Me
3-(2-pyridyl)-Ph


4386
4-Cl
Me
3-(2-thienyl)-Ph


4387
4-Cl
Me
3-(2-furanyl)-Ph


4388
4-Cl
Me
4-CN—Ph


4389
4-Cl
Me
4-COMe—Ph


4390
4-Cl
Me
4-CO2Me—Ph


4391
4-Cl
Me
4-CONH2-Ph


4392
4-Cl
Me
4-CONHMe—Ph


4393
4-Cl
Me
4-CONHPh—Ph


4394
4-Cl
Me
4-F—Ph


4395
4-Cl
Me
4-Cl—Ph


4396
4-Cl
Me
4-Br—Ph


4397
4-Cl
Me
4-SO2NH2-Ph


4398
4-Cl
Me
4-SO2NHMe—Ph


4399
4-Cl
Me
4-CF3—Ph


4400
4-Cl
Me
4-OMe—Ph


4401
4-Cl
Me
4-SMe—Ph


4402
4-Cl
Me
4-SOMe—Ph


4403
4-Cl
Me
4-SO2Me—Ph


4404
4-Cl
Me
4-OH—Ph


4405
4-Cl
Me
4-CH2OH—Ph


4406
4-Cl
Me
4-CHOHMe—Ph


4407
4-Cl
Me
4-COH(Me)2—Ph


4408
4-Cl
Me
4-Me—Ph


4409
4-Cl
Me
4-Et—Ph


4410
4-Cl
Me
4-iPr—Ph


4411
4-Cl
Me
4-tBu—Ph


4412
4-Cl
Me
4-CH2CO2Me—Ph


4413
4-Cl
Me
4-(1-piperidinyl)-Ph


4414
4-Cl
Me
4-(1-pyrrolidinyl)-Ph


4415
4-Cl
Me
4-(2-imidazolyl)-Ph


4416
4-Cl
Me
4-(1-imidazolyl)-Ph


4417
4-Cl
Me
4-(2-thiazolyl)-Ph


4418
4-Cl
Me
4-(3-pyrazolyl)-Ph


4419
4-Cl
Me
4-(1-pyrazolyl)-Ph


4420
4-Cl
Me
4-(5-Me-1-tetrazolyl)-Ph


4421
4-Cl
Me
4-(1-Me-5-tetrazolyl)-Ph


4422
4-Cl
Me
4-(2-pyridyl)-Ph


4423
4-Cl
Me
4-(2-thienyl)-Ph


4424
4-Cl
Me
4-(2-furanyl)-Ph


4425
4-Cl
Me
2-CN—Ph


4426
4-Cl
Me
2-COMe—Ph


4427
4-Cl
Me
2-CO2Me—Ph


4428
4-Cl
Me
2-CONH2-Ph


4429
4-Cl
Me
2-CONHMe—Ph


4430
4-Cl
Me
2-F—Ph


4431
4-Cl
Me
2-Cl—Ph


4432
4-Cl
Me
2-Br—Ph


4433
4-Cl
Me
2-SO2NH2-Ph


4434
4-Cl
Me
2-SO2NHMe—Ph


4435
4-Cl
Me
2-CF3—Ph


4436
4-Cl
Me
2-OMe—Ph


4437
4-Cl
Me
2-SMe—Ph


4438
4-Cl
Me
2-SOMe—Ph


4439
4-Cl
Me
2-SO2Me—Ph


4440
4-Cl
Me
2-OH—Ph


4441
4-Cl
Me
2-CH2OH—Ph


4442
4-Cl
Me
2-CHOHMe—Ph


4443
4-Cl
Me
2-COH(Me)2—Ph


4444
4-Cl
Me
2-Me—Ph


4445
4-Cl
Me
2-Et—Ph


4446
4-Cl
Me
2-iPr—Ph


4447
4-Cl
Me
2-tBu—Ph


4448
4-Cl
Me
2-CH2CO2Me—Ph


4449
4-Cl
Me
2-(1-piperidinyl)-Ph


4450
4-Cl
Me
2-(1-pyrrolidinyl)-Ph


4451
4-Cl
Me
2-(2-imidazolyl)-Ph


4452
4-Cl
Me
2-(1-imidazolyl)-Ph


4453
4-Cl
Me
2-(2-thiazolyl)-Ph


4454
4-Cl
Me
2-(3-pyrazolyl)-Ph


4455
4-Cl
Me
2-(1-pyrazolyl)-Ph


4456
4-Cl
Me
2-(5-Me-1-tetrazolyl)-Ph


4457
4-Cl
Me
2-(1-Me-5-tetrazolyl)-Ph


4458
4-Cl
Me
2-(2-pyridyl)-Ph


4459
4-Cl
Me
2-(2-thienyl)-Ph


4460
4-Cl
Me
2-(2-furanyl)-Ph


4461
4-Cl
Me
2,4-diF—Ph


4462
4-Cl
Me
2,5-diF—Ph


4463
4-Cl
Me
2,6-diF—Ph


4464
4-Cl
Me
3,4-diF—Ph


4465
4-Cl
Me
3,5-diF—Ph


4466
4-Cl
Me
2,4-diCl—Ph


4467
4-Cl
Me
2,5-diCl—Ph


4468
4-Cl
Me
2,6-diCl—Ph


4469
4-Cl
Me
3,4-diCl—Ph


4470
4-Cl
Me
3,5-diCl—Ph


4471
4-Cl
Me
3,4-diCF3—Ph


4472
4-Cl
Me
3,5-diCF3—Ph


4473
4-Cl
Me
5-Cl-2-MeO—Ph


4474
4-Cl
Me
5-Cl-2-Me—Ph


4475
4-Cl
Me
2-F-5-Me—Ph


4476
4-Cl
Me
3-F-5-morpholino-Ph


4477
4-Cl
Me
3,4-OCH2O—Ph


4478
4-Cl
Me
3,4-OCH2CH2O—Ph


4479
4-Cl
Me
2-MeO-5-CONH2—Ph


4480
4-Cl
Me
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


4481
4-Cl
Me
2-MeO-5-(1-Me-5-tetrazolyl)-Ph


4482
4-Cl
Me
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


4483
4-Cl
Me
1-naphthyl


4484
4-Cl
Me
2-naphthyl


4485
4-Cl
Me
2-thienyl


4486
4-Cl
Me
3-thienyl


4487
4-Cl
Me
2-furanyl


4488
4-Cl
Me
3-furanyl


4489
4-Cl
Me
2-pyridyl


4490
4-Cl
Me
3-pyridyl


4491
4-Cl
Me
4-pyridyl


4492
4-Cl
Me
2-indolyl


4493
4-Cl
Me
3-indolyl


4494
4-Cl
Me
5-indolyl


4495
4-Cl
Me
6-indolyl


4496
4-Cl
Me
3-indazolyl


4497
4-Cl
Me
5-indazolyl


4498
4-Cl
Me
6-indazolyl


4499
4-Cl
Me
2-irnidazolyl


4500
4-Cl
Me
3-isoxazoyl


4501
4-Cl
Me
3-pyrazolyl


4502
4-Cl
Me
2-thiadiazolyl


4503
4-Cl
Me
2-thiazolyl


4504
4-Cl
Me
5-Ac-4-Me-2-thiazolyl


4505
4-Cl
Me
5-tetrazolyl


4506
4-Cl
Me
2-benzimidazolyl


4507
4-Cl
Me
5-benzimidazolyl


4508
4-Cl
Me
2-benzothiazolyl


4509
4-Cl
Me
5-benzothiazolyl


4510
4-Cl
Me
2-benzoxazolyl


4511
4-Cl
Me
5-benzoxazolyl


4512
4-Cl
Me
1-adamantyl


4513
4-Cl
Me
2-adamantyl


4514
4-Cl
Me
i-Pr


4515
4-Cl
Me
t-Bu


4516
4-Cl
Me
c-Hex


4517
4-Cl
Me
CH2CH2OMe


4518
4-Cl
Me
CH2CONH2


4519
4-Cl
Me
CH2CO2Me


4520
4-Cl
Me
CH(CH2Ph)CO2Me


4521
4-Cl
Me
CH2CH2NMe2


4522
4-Cl
Me
benzyl


4523
4-Cl
Me
phenethyl


4524
4-Cl
Me
2-(morpholin-1-yl)-Et


4525
4-Cl
2-F—Et
Ph


4526
4-Cl
2-F—Et
3-CN—Ph


4527
4-Cl
2-F—Et
3-COMe—Ph


4528
4-Cl
2-F—Et
3-CO2Me—Ph


4529
4-Cl
2-F—Et
3-CONH2—Ph


4530
4-Cl
2-F—Et
3-CONHMe—Ph


4531
4-Cl
2-F—Et
3-F—Ph


4532
4-Cl
2-F—Et
3-Cl—Ph


4533
4-Cl
2-F—Et
3-Br—Ph


4534
4-Cl
2-F—Et
3-SO2NH2—Ph


4535
4-Cl
2-F—Et
3-SO2NHMe—Ph


4536
4-Cl
2-F—Et
3-CF3—Ph


4537
4-Cl
2-F—Et
3-OMe—Ph


4538
4-Cl
2-F—Et
3-SMe—Ph


4539
4-Cl
2-F—Et
3-SOMe—Ph


4540
4-Cl
2-F—Et
3-SO2Me—Ph


4541
4-Cl
2-F—Et
3-OH—Ph


4542
4-Cl
2-F—Et
3-CH2OH—Ph


4543
4-Cl
2-F—Et
3-CHOHMe—Ph


4544
4-Cl
2-F—Et
3-COH(Me)2—Ph


4545
4-Cl
2-F—Et
3-Me—Ph


4546
4-Cl
2-F—Et
3-Et—Ph


4547
4-Cl
2-F—Et
3-iPr—Ph


4548
4-Cl
2-F—Et
3-tBu—Ph


4549
4-Cl
2-F—Et
3-CH2CO2Me—Ph


4550
4-Cl
2-F—Et
3-(1-piperidinyl)-Ph


4551
4-Cl
2-F—Et
3-(1-pyrrolidinyl)-Ph


4552
4-Cl
2-F—Et
3-(2-imidazolyl)-Ph


4553
4-Cl
2-F—Et
3-(1-imidazolyl)-Ph


4554
4-Cl
2-F—Et
3-(2-thiazolyl)-Ph


4555
4-Cl
2-F—Et
3-(3-pyrazolyl)-Ph


4556
4-Cl
2-F—Et
3-(1-pyrazolyl)-Ph


4557
4-Cl
2-F—Et
3-(5-Me-1-tetrazolyl)-Ph


4558
4-Cl
2-F—Et
3-(1-Me-5-tetrazolyl)-Ph


4559
4-Cl
2-F—Et
3-(2-pyridyl)-Ph


4560
4-Cl
2-F—Et
3-(2-thienyl)-Ph


4561
4-Cl
2-F—Et
3-(2-furanyl)-Ph


4562
4-Cl
2-F—Et
4-CN—Ph


4563
4-Cl
2-F—Et
4-COMe—Ph


4564
4-Cl
2-F—Et
4-CO2Me—Ph


4565
4-Cl
2-F—Et
4-CONH2—Ph


4566
4-Cl
2-F—Et
4-CONHMe—Ph


4567
4-Cl
2-F—Et
4-CONHPh—Ph


4568
4-Cl
2-F—Et
4-F—Ph


4569
4-Cl
2-F—Et
4-Cl—Ph


4570
4-Cl
2-F—Et
4-Br—Ph


4571
4-Cl
2-F—Et
4-SO2NH2—Ph


4572
4-Cl
2-F—Et
4-SO2NHMe—Ph


4573
4-Cl
2-F—Et
4-CF3—Ph


4574
4-Cl
2-F—Et
4-OMe—Ph


4575
4-Cl
2-F—Et
4-SMe—Ph


4576
4-Cl
2-F—Et
4-SOMe—Ph


4577
4-Cl
2-F—Et
4-SO2Me—Ph


4578
4-Cl
2-F—Et
4-OH—Ph


4579
4-Cl
2-F—Et
4-CH2OH—Ph


4580
4-Cl
2-F—Et
4-CHOHMe—Ph


4581
4-Cl
2-F—Et
4-COH(Me)2—Ph


4582
4-Cl
2-F—Et
4-Me—Ph


4583
4-Cl
2-F—Et
4-Et—Ph


4584
4-Cl
2-F—Et
4-iPr—Ph


4585
4-Cl
2-F—Et
4-tBu—Ph


4586
4-Cl
2-F—Et
4-CH2CO2Me—Ph


4587
4-Cl
2-F—Et
4-(1-piperidinyl)-Ph


4588
4-Cl
2-F—Et
4-(1-pyrrolidinyl)-Ph


4589
4-Cl
2-F—Et
4-(2-imidazolyl)-Ph


4590
4-Cl
2-F—Et
4-(1-imidazolyl)-Ph


4591
4-Cl
2-F—Et
4-(2-thiazolyl)-Ph


4592
4-Cl
2-F—Et
4-(3-pyrazolyl)-Ph


4593
4-Cl
2-F—Et
4-(1-pyrazolyl)-Ph


4594
4-Cl
2-F—Et
4-(5-Me-1-tetrazolyl)-Ph


4595
4-Cl
2-F—Et
4-(1-Me-5-tetrazol-Ph


4596
4-Cl
2-F—Et
4-(2-pyridyl)-Ph


4597
4-Cl
2-F—Et
4-(2-thienyl)-Ph


4598
4-Cl
2-F—Et
4-(2-furanyl)-Ph


4599
4-Cl
2-F—Et
2-CN—Ph


4600
4-Cl
2-F—Et
2-COMe—Ph


4601
4-Cl
2-F—Et
2-CO2Me—Ph


4602
4-Cl
2-F—Et
2-CONH2-Ph


4603
4-Cl
2-F—Et
2-CONHMe—Ph


4604
4-Cl
2-F—Et
2-F—Ph


4605
4-Cl
2-F—Et
2-Cl—Ph


4606
4-Cl
2-F—Et
2-Br—Ph


4607
4-Cl
2-F—Et
2-SO2NH2—Ph


4608
4-Cl
2-F—Et
2-SO2NHMe—Ph


4609
4-Cl
2-F—Et
2-CF3—Ph


4610
4-Cl
2-F—Et
2-OMe—Ph


4611
4-Cl
2-F—Et
2-SMe—Ph


4612
4-Cl
2-F—Et
2-SOMe—Ph


4613
4-Cl
2-F—Et
2-SO2Me—Ph


4614
4-Cl
2-F—Et
2-OH—Ph


4615
4-Cl
2-F—Et
2-CH2OH—Ph


4616
4-Cl
2-F—Et
2-CHOHMe—Ph


4617
4-Cl
2-F—Et
2-COH(Me)2—Ph


4618
4-Cl
2-F—Et
2-Me—Ph


4619
4-Cl
2-F—Et
2-Et—Ph


4620
4-Cl
2-F—Et
2-iPr—Ph


4621
4-Cl
2-F—Et
2-tBu—Ph


4622
4-Cl
2-F—Et
2-CH2CO2Me—Ph


4623
4-Cl
2-F—Et
2-(1-piperidinyl)-Ph


4624
4-Cl
2-F—Et
2-(1-pyrrolidinyl)-Ph


4625
4-Cl
2-F—Et
2-(2-imidazolyl)-Ph


4626
4-Cl
2-F—Et
2-(1-imidazolyl)-Ph


4627
4-Cl
2-F—Et
2-(2-thiazolyl)-Ph


4628
4-Cl
2-F—Et
2-(3-pyrazolyl)-Ph


4629
4-Cl
2-F—Et
2-(1-pyrazolyl)-Ph


4630
4-Cl
2-F—Et
2-(5-Me-1-tetrazolyl)-Ph


4631
4-Cl
2-F—Et
2-(1-Me-5-tetrazolyl)-Ph


4632
4-Cl
2-F—Et
2-(2-pyridyl)-Ph


4633
4-Cl
2-F—Et
2-(thienyl)-Ph


4634
4-Cl
2-F—Et
2-(2-furanyl)-Ph


4635
4-Cl
2-F—Et
2,4-diF—Ph


4636
4-Cl
2-F—Et
2,5-diF—Ph


4637
4-Cl
2-F—Et
2,6-diF—Ph


4638
4-Cl
2-F—Et
3,4-diF—Ph


4639
4-Cl
2-F—Et
3,5-diF—Ph


4640
4-Cl
2-F—Et
2,4-diCl—Ph


4641
4-Cl
2-F—Et
2,5-diCl—Ph


4642
4-Cl
2-F—Et
2,6-diCl—Ph


4643
4-Cl
2-F—Et
3,4-diCl—Ph


4644
4-Cl
2-F—Et
3,5-diCl—Ph


4645
4-Cl
2-F—Et
3,4-diCF3—Ph


4646
4-Cl
2-F—Et
3,5-diCF3—Ph


4647
4-Cl
2-F—Et
5-Cl-2-MeO—Ph


4648
4-Cl
2-F—Et
5-Cl-2-Me—Ph


4649
4-Cl
2-F—Et
2-F-5-Me—Ph


4650
4-Cl
2-F—Et
3-F-5-morpholino-Ph


4651
4-Cl
2-F—Et
3,4-OCH2O—Ph


4652
4-Cl
2-F—Et
3,4-OCH2CH2O—Ph


4653
4-Cl
2-F—Et
2-MeO-5-CONH2—Ph


4654
4-Cl
2-F—Et
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


4655
4-Cl
2-F—Et
2-MeO-5-(1-Me-5-tetrazolyl)-Ph


4656
4-Cl
2-F—Et
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


4657
4-Cl
2-F—Et
1-naphthyl


4658
4-Cl
2-F—Et
2-naphthyl


4659
4-Cl
2-F—Et
2-thienyl


4660
4-Cl
2-F—Et
3-thienyl


4661
4-Cl
2-F—Et
2-furanyl


4662
4-Cl
2-F—Et
3-furanyl


4663
4-Cl
2-F—Et
2-pyridyl


4664
4-Cl
2-F—Et
3-pyridyl


4665
4-Cl
2-F—Et
4-pyridyl


4666
4-Cl
2-F—Et
2-indolyl


4667
4-Cl
2-F—Et
3-indolyl


4668
4-Cl
2-F—Et
5-indolyl


4669
4-Cl
2-F—Et
6-indolyl


4670
4-Cl
2-F—Et
3-indazolyl


4671
4-Cl
2-F—Et
5-indazolyl


4672
4-Cl
2-F—Et
6-indazolyl


4673
4-Cl
2-F—Et
2-imidazolyl


4674
4-Cl
2-F—Et
3-isoxazoyl


4675
4-Cl
2-F—Et
3-pyrazolyl


4676
4-Cl
2-F—Et
2-thiadiazolyl


4677
4-Cl
2-F—Et
2-thiazolyl


4678
4-Cl
2-F—Et
5-Ac-4-Me-2-thiazolyl


4679
4-Cl
2-F—Et
5-tetrazolyl


4680
4-Cl
2-F—Et
2-benzimidazolyl


4681
4-Cl
2-F—Et
5-benzimidazolyl


4682
4-Cl
2-F—Et
2-benzothiazolyl


4683
4-Cl
2-F—Et
5-benzothiazolyl


4684
4-Cl
2-F—Et
2-benzoxazolyl


4685
4-Cl
2-F—Et
5-benzoxazolyl


4686
4-Cl
2-F—Et
1-adamantyl


4687
4-Cl
2-F—Et
2-adamantyl


4688
4-Cl
2-F—Et
i-Pr


4689
4-Cl
2-F—Et
t-Bu


4690
4-Cl
2-F—Et
c-Hex


4691
4-Cl
2-F—Et
CH2CH2OMe


4692
4-Cl
2-F—Et
CH2CONH2


4693
4-Cl
2-F—Et
CH2CO2Me


4694
4-Cl
2-F—Et
CH(CH2Ph)CO2Me


4695
4-Cl
2-F—Et
CH2CH2NMe2


4696
4-Cl
2-F—Et
benzyl


4697
4-Cl
2-F—Et
phenethyl


4698
4-Cl
2-F—Et
2-(morpholin-1-yl)-Et


4699
4-Cl
CO2Me
Ph


4700
4-Cl
CO2Me
3-CN—Ph


4701
4-Cl
CO2Me
3-COMe—Ph


4702
4-Cl
CO2Me
3-CO2Me—Ph


4703
4-Cl
CO2Me
3-CONH2—Ph


4704
4-Cl
CO2Me
3-CONHMe—Ph


4705
4-Cl
CO2Me
3-F—Ph


4706
4-Cl
CO2Me
3-Cl—Ph


4707
4-Cl
CO2Me
3-Br—Ph


4708
4-Cl
CO2Me
3-SO2NH2—Ph


4709
4-Cl
CO2Me
3-SO2NHMe—Ph


4710
4-Cl
CO2Me
3-CF3—Ph


4711
4-Cl
CO2Me
3-OMe—Ph


4712
4-Cl
CO2Me
3-SMe—Ph


4713
4-Cl
CO2Me
3-SOMe—Ph


4714
4-Cl
CO2Me
3-SO2Me—Ph


4715
4-Cl
CO2Me
3-OH—Ph


4716
4-Cl
CO2Me
3-CH2OH—Ph


4717
4-Cl
CO2Me
3-CHOHMe—Ph


4718
4-Cl
CO2Me
3-COH(Me)2—Ph


4719
4-Cl
CO2Me
3-Me—Ph


4720
4-Cl
CO2Me
3-Et—Ph


4721
4-Cl
CO2Me
3-iPr—Ph


4722
4-Cl
CO2Me
3-tBu—Ph


4723
4-Cl
CO2Me
3-CH2CO2Me—Ph


4724
4-Cl
CO2Me
3-(1-piperidinyl)-Ph


4725
4-Cl
CO2Me
3-(1-pyrrolidinyl)-Ph


4726
4-Cl
CO2Me
3-(2-imidazolyl)-Ph


4727
4-Cl
CO2Me
3-(1-imidazolyl)-Ph


4728
4-Cl
CO2Me
3-(2-thiazolyl)-Ph


4729
4-Cl
CO2Me
3-(3-pyrazolyl)-Ph


4730
4-Cl
CO2Me
3-(1-pyrazolyl)-Ph


4731
4-Cl
CO2Me
3-(5-Me-1-tetrazolyl)-Ph


4732
4-Cl
CO2Me
3-(1-Me-5-tetrazolyl)-Ph


4733
4-Cl
CO2Me
3-(2-pyridyl)-Ph


4734
4-Cl
CO2Me
3-(2-thienyl)-Ph


4735
4-Cl
CO2Me
3-(2-furanyl)-Ph


4736
4-Cl
CO2Me
4-CN—Ph


4737
4-Cl
CO2Me
4-COMe—Ph


4738
4-Cl
CO2Me
4-CO2Me—Ph


4739
4-Cl
CO2Me
4-CONH2-Ph


4740
4-Cl
CO2Me
4-CONHMe—Ph


4741
4-Cl
CO2Me
4-CONHPh—Ph


4742
4-Cl
CO2Me
4-F—Ph


4743
4-Cl
CO2Me
4-Cl—Ph


4744
4-Cl
CO2Me
4-Br—Ph


4745
4-Cl
CO2Me
4-SO2NH2—Ph


4746
4-Cl
CO2Me
4-SO2NHMe—Ph


4747
4-Cl
CO2Me
4-CF3—Ph


4748
4-Cl
CO2Me
4-OMe—Ph


4749
4-Cl
CO2Ne
4-SMe—Ph


4750
4-Cl
CO2Me
4-SOMe—Ph


4751
4-Cl
CO2Me
4-SO2Me—Ph


4752
4-Cl
CO2Me
4-OH—Ph


4753
4-Cl
CO2Me
4-CH2OH—Ph


4754
4-Cl
CO2Me
4-CHOHMe—Ph


4755
4-Cl
CO2Me
4-COH(Me)2—Ph


4756
4-Cl
CO2Me
4-Me—Ph


4757
4-Cl
CO2Me
4-Et—Ph


4758
4-Cl
CO2Me
4-iPr—Ph


4759
4-Cl
CO2Me
4-tBu—Ph


4760
4-Cl
CO2Me
4-CH2CO2Me—Ph


4761
4-Cl
CO2Me
4-(1-piperidinyl)-Ph


4762
4-Cl
CO2Me
4-(1-pyrrolidinyl)-Ph


4763
4-Cl
CO2Me
4-(2-imidazolyl)-Ph


4764
4-Cl
CO2Me
4-(1-imidazolyl)-Ph


4765
4-Cl
CO2Me
4-(2-thiazolyl)-Ph


4766
4-Cl
CO2Me
4-(3-pyrazolyl)-Ph


4767
4-Cl
CO2Me
4-(1-pyrazolyl)-Ph


4768
4-Cl
CO2Me
4-(5-Me-1-tetrazolyl)-Ph


4769
4-Cl
CO2Me
4-(1-Me-5-tetrazolyl)-Ph


4770
4-Cl
CO2Me
4-(2-pyridyl)-Ph


4771
4-Cl
CO2Me
4-(2-thienyl)-Ph


4772
4-Cl
CO2Me
4-(2-furanyl)-Ph


4773
4-Cl
CO2Me
2-CN—Ph


4774
4-Cl
CO2Me
2-COMe—Ph


4775
4-Cl
CO2Me
2-CO2Me—Ph


4776
4-Cl
CO2Me
2-CONH2-Ph


4777
4-Cl
CO2Me
2-CONHMe—Ph


4778
4-Cl
CO2Me
2-F—Ph


4779
4-Cl
CO2Me
2-Cl—Ph


4780
4-Cl
CO2Me
2-Br—Ph


4781
4-Cl
CO2Me
2-SO2NH2—Ph


4782
4-Cl
CO2Me
2-SO2NHMe—Ph


4783
4-Cl
CO2Me
2-CF3—Ph


4784
4-Cl
CO2Me
2-OMe—Ph


4785
4-Cl
CO2Me
2-SMe—Ph


4786
4-Cl
CO2Me
2-SOMe—Ph


4787
4-Cl
CO2Me
2-SO2Me—Ph


4788
4-Cl
CO2Me
2-OH—Ph


4789
4-Cl
CO2Me
2-CH2OH—Ph


4790
4-Cl
CO2Me
2-CHOHMe—Ph


4791
4-Cl
CO2Me
2-COH(Me)2—Ph


4792
4-Cl
CO2Me
2-Me—Ph


4793
4-Cl
CO2Me
2-Et—Ph


4794
4-Cl
CO2Me
2-iPr—Ph


4795
4-Cl
CO2Me
2-tBu—Ph


4796
4-Cl
CO2Me
2-CH2CO2Me—Ph


4797
4-Cl
CO2Me
2-(1-piperidinyl)-Ph


4798
4-Cl
CO2Me
2-(1-pyrrolidinyl)-Ph


4799
4-Cl
CO2Me
2-(2-imidazolyl)-Ph


4800
4-Cl
CO2Me
2-(1-imidazolyl)-Ph


4801
4-Cl
CO2Me
2-(2-thiazolyl)-Ph


4802
4-Cl
CO2Me
2-(3-pyrazolyl)-Ph


4803
4-Cl
CO2Me
2-(1-pyrazolyl)-Ph


4804
4-Cl
CO2Me
2-(5-Me-1-tetrazolyl)-Ph


4805
4-Cl
CO2Me
2-(1-Me-5-tetrazolyl)-Ph


4806
4-Cl
CO2Me
2-(2-pyridyl)-Ph


4807
4-Cl
CO2Me
2-(2-thienyl)-Ph


4808
4-Cl
CO2Me
2-(2-furanyl)-Ph


4820
4-Cl
CO2Me
3,5-diCF3—Ph


4821
4-Cl
CO2Me
5-Cl-2-MeO—Ph


4822
4-Cl
CO2Me
5-Cl-2-Me—Ph


4823
4-Cl
CO2Me
2-F-5-Me—Ph


4824
4-Cl
CO2Me
3-F-5-morpholino-Ph


4825
4-Cl
CO2Me
3,4-OCH2O—Ph


4826
4-Cl
CO2Me
3,4-OCH2CH2O—Ph


4827
4-Cl
CO2Me
2-MeO-5-CONH2-Ph


4828
4-Cl
CO2Me
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


4829
4-Cl
CO2Me
2-MeO-5-(1-Me-5-tetrazolyl)-Ph


4830
4-Cl
CO2Me
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


4831
4-Cl
CO2Me
1-naphthyl


4832
4-Cl
CO2Me
2-naphthyl


4833
4-Cl
CO2Me
2-thienyl


4834
4-Cl
CO2Me
3-thienyl


4835
4-Cl
CO2Me
2-furanyl


4836
4-Cl
CO2Me
3-furanyl


4837
4-Cl
CO2Me
2-pyridyl


4838
4-Cl
CO2Me
3-pyridyl


4839
4-Cl
CO2Me
4-pyridyl


4840
4-Cl
CO2Me
2-indolyl


4841
4-Cl
CO2Me
3-indolyl


4842
4-Cl
CO2Me
5-indolyl


4843
4-Cl
CO2Me
6-indolyl


4844
4-Cl
CO2Me
3-indazolyl


4845
4-Cl
CO2Me
5-indazolyl


4846
4-Cl
CO2Me
6-indazolyl


4847
4-Cl
CO2Me
2-imidazolyl


4848
4-Cl
CO2Me
3-isoxazoyl


4849
4-Cl
CO2Me
3-pyrazolyl


4850
4-Cl
CO2Me
2-thiadiazolyl


4851
4-Cl
CO2Me
2-thiazolyl


4852
4-Cl
CO2Me
5-Ac-4-Me-2-thiazolyl


4853
4-Cl
CO2Me
5-tetrazolyl


4854
4-Cl
CO2Me
2-benzimidazolyl


4855
4-Cl
CO2Me
5-benzimidazolyl


4856
4-Cl
CO2Me
2-benzothiazolyl


4857
4-Cl
CO2Me
5-benzothiazolyl


4858
4-Cl
CO2Me
2-benzoxazolyl


4859
4-Cl
CO2Me
5-benzoxazolyl


4860
4-Cl
CO2Me
1-adamantyl


4861
4-Cl
CO2Me
2-adamantyl


4862
4-Cl
CO2Me
i-Pr


4863
4-Cl
CO2Me
t-Bu


4864
4-Cl
CO2Me
c-Hex


4865
4-Cl
CO2Me
CH2CH2OMe


4866
4-Cl
CO2Me
CH2CONH2


4867
4-Cl
CO2Me
CH2CO2Me


4868
4-Cl
CO2Me
CH(CH2Ph)CO2Me


4869
4-Cl
CO2Me
CH2CH2NMe2


4870
4-Cl
CO2Me
benzyl


4871
4-Cl
CO2Me
phenethyl


4872
4-Cl
CO2Me
2-(morpholin-1-yl)-Et


4873
4-Cl
Ac
Ph


4874
4-Cl
Ac
3-CN—Ph


4876
4-Cl
Ac
3-CO2Me—Ph


4877
4-Cl
Ac
3-CONH2—Ph


4879
4-Cl
Ac
3-F—Ph


4880
4-Cl
Ac
3-Cl—Ph


4882
4-Cl
Ac
3-SO2NH2—Ph


4883
4-Cl
Ac
3-SO2NHMe—Ph


4884
4-Cl
Ac
3-CF3—Ph


4885
4-Cl
Ac
3-OMe—Ph


4886
4-Cl
Ac
3-SMe—Ph


4887
4-Cl
Ac
3-SOMe—Ph


4888
4-Cl
Ac
3-SO2Me—Ph


4889
4-Cl
Ac
3-OH—Ph


4890
4-Cl
Ac
3-CH2OH—Ph


4891
4-Cl
Ac
3-CHOHMe—Ph


4892
4-Cl
Ac
3-COH(Me)2—Ph


4893
4-Cl
Ac
3-Me—Ph


4894
4-Cl
Ac
3-Et—Ph


4895
4-Cl
Ac
3-iPr—Ph


4896
4-Cl
Ac
3-tBu—Ph


4897
4-Cl
Ac
3-CH2CO2Me—Ph


4898
4-Cl
Ac
3-(1-piperidinyl)-Ph


4899
4-Cl
Ac
3-(1-pyrrolidinyl)-Ph


4900
4-Cl
Ac
3-(2-imidazolyl)-Ph


4901
4-Cl
Ac
3-(1-imidazolyl)-Ph


4902
4-Cl
Ac
3-(2-thiazolyl)-Ph


4903
4-Cl
Ac
3-(3-pyrazolyl)-Ph


4904
4-Cl
Ac
3-(1-pyrazolyl)-Ph


4905
4-Cl
Ac
3-(5-Me-1-tetrazolyl)-Ph


4906
4-Cl
Ac
3-(1-Me-5-tetrazolyl)-Ph


4907
4-Cl
Ac
3-(2-pyridyl)-Ph


4908
4-Cl
Ac
3-(2-thienyl)-Ph


4909
4-Cl
Ac
3-(2-furanyl)-Ph


4910
4-Cl
Ac
4-CN—Ph


4911
4-Cl
Ac
4-COMe—Ph


4912
4-Cl
Ac
4-CO2Me—Ph


4913
4-Cl
Ac
4-CONH2—Ph


4914
4-Cl
Ac
4-CONHMe—Ph


4915
4-Cl
Ac
4-CONHPh—Ph


4916
4-Cl
Ac
4-F—Ph


4917
4-Cl
Ac
4-Cl—Ph


4918
4-Cl
Ac
4-Br—Ph


4919
4-Cl
Ac
4-SO2NH2—Ph


4920
4-Cl
Ac
4-SO2NHMe—Ph


4921
4-Cl
Ac
4-CF3—Ph


4922
4-Cl
Ac
4-OMe—Ph


4923
4-Cl
Ac
4-SMe—Ph


4924
4-Cl
Ac
4-SOMe—Ph


4925
4-Cl
Ac
4-SO2Me—Ph


4926
4-Cl
Ac
4-OH—Ph


4927
4-Cl
Ac
4-CH2OH—Ph


4928
4-Cl
Ac
4-CHOHMe—Ph


4929
4-Cl
Ac
4-COH(Me)2—Ph


4930
4-Cl
Ac
4-Me—Ph


4931
4-Cl
Ac
4-Et—Ph


4932
4-Cl
Ac
4-iPr—Ph


4933
4-Cl
Ac
4-tBu—Ph


4934
4-Cl
Ac
4-CH2CO2Me—Ph


4935
4-Cl
Ac
4-(1-piperidinyl)-Ph


4936
4-Cl
Ac
4-(1-pyrrolidinyl)-Ph


4937
4-Cl
Ac
4-(2-imidazolyl)-Ph


4938
4-Cl
Ac
4-(1-imidazolyl)-Ph


4939
4-Cl
Ac
4-(2-thiazolyl)-Ph


4940
4-Cl
Ac
4-(3-pyrazolyl)-Ph


4941
4-Cl
Ac
4-(1-pyrazolyl)-Ph


4942
4-Cl
Ac
4-(5-Me-1-tetrazolyl)-Ph


4943
4-Cl
Ac
4-(1-Me-5-tetrazolyl)-Ph


4944
4-Cl
Ac
4-(2-pyridyl)-Ph


4945
4-Cl
Ac
4-(2-thienyl)-Ph


4946
4-Cl
Ac
4-(2-furanyl)-Ph


4947
4-Cl
Ac
2-CN—Ph


4948
4-Cl
Ac
2-COMe—Ph


4949
4-Cl
Ac
2-CO2Me—Ph


4950
4-Cl
Ac
2-CONH2—Ph


4951
4-Cl
Ac
2-CONHMe—Ph


4952
4-Cl
Ac
2-F—Ph


4953
4-Cl
Ac
2-Cl—Ph


4954
4-Cl
Ac
2-Br—Ph


4955
4-Cl
Ac
2-SO2NH2—Ph


4956
4-Cl
Ac
2-SO2NHMe—Ph


4957
4-Cl
Ac
2-CF3—Ph


4958
4-Cl
Ac
2-OMe—Ph


4959
4-Cl
Ac
2-SMe—Ph


4960
4-Cl
Ac
2-SOMe—Ph


4961
4-Cl
Ac
2-SO2Me—Ph


4962
4-Cl
Ac
2-OH—Ph


4963
4-Cl
Ac
2-CH2OH—Ph


4964
4-Cl
Ac
2-CHOHNe—Ph


4965
4-Cl
Ac
2-COH(Me)2—Ph


4966
4-Cl
Ac
2-Me—Ph


4967
4-Cl
Ac
2-Et—Ph


4968
4-Cl
Ac
2-iPr—Ph


4969
4-Cl
Ac
2-tBu—Ph


4970
4-Cl
Ac
2-CH2CO2Me—Ph


4971
4-Cl
Ac
2-(1-piperidinyl)-Ph


4972
4-Cl
Ac
2-(1-pyrrolidinyl)-Ph


4973
4-Cl
Ac
2-(2-imidazolyl)-Ph


4974
4-Cl
Ac
2-(1-imidazolyl)-Ph


4975
4-Cl
Ac
2-(2-thiazolyl)-Ph


4976
4-Cl
Ac
2-(3-pyrazolyl)-Ph


4977
4-Cl
Ac
2-(1-pyrazolyl)-Ph


4978
4-Cl
Ac
2-(5-Me-1-tetrazolyl)-Ph


4979
4-Cl
Ac
2-(1-Me-5-tetrazolyl)-Ph


4980
4-Cl
Ac
2-(2-pyridyl)-Ph


4981
4-Cl
Ac
2-(2-thienyl)-Ph


4982
4-Cl
Ac
2-(2-furanyl)-Ph


4983
4-Cl
Ac
2,4-diF—Ph


4984
4-Cl
Ac
2,5-diF—Ph


4985
4-Cl
Ac
2,6-diF—Ph


4986
4-Cl
Ac
3,4-diF—Ph


4987
4-Cl
Ac
3,5-diF—Ph


4988
4-Cl
Ac
2,4-diCl—Ph


4989
4-Cl
Ac
2,5-diCl—Ph


4990
4-Cl
Ac
2,6-diCl—Ph


4991
4-Cl
Ac
3,4-diCl—Ph


4992
4-Cl
Ac
3,5-diCl—Ph


4993
4-Cl
Ac
3,4-diCF3—Ph


4994
4-Cl
Ac
3,5-diCF3—Ph


4995
4-Cl
Ac
5-Cl-2-MeO—Ph


4996
4-Cl
Ac
5-Cl-2-Me—Ph


4997
4-Cl
Ac
2-F-5-Me—Ph


4998
4-Cl
Ac
3-F-5-morpholino-Ph


4999
4-Cl
Ac
3,4-OCH2O—Ph


5000
4-Cl
Ac
3,4-OCH2CH2O—Ph


5001
4-Cl
Ac
2-MeO-5-CONH2—Ph


5002
4-Cl
Ac
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


5003
4-Cl
Ac
2-MeO-5-(1-Me-5-tetrazolyl)-Ph


5004
4-Cl
Ac
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


5005
4-Cl
Ac
1-naphthyl


5006
4-Cl
Ac
2-naphthyl


5007
4-Cl
Ac
2-thienyl


5008
4-Cl
Ac
3-thienyl


5009
4-Cl
Ac
2-furanyl


5010
4-Cl
Ac
3-furanyl


5011
4-Cl
Ac
2-pyridyl


5012
4-Cl
Ac
3-pyridyl


5013
4-Cl
Ac
4-pyridyl


5014
4-Cl
Ac
2-indolyl


5015
4-Cl
Ac
3-indolyl


5016
4-Cl
Ac
5-indolyl


5017
4-Cl
Ac
6-indolyl


5018
4-Cl
Ac
3-indazolyl


5019
4-Cl
Ac
5-indazolyl


5020
4-Cl
Ac
6-indazolyl


5021
4-Cl
Ac
2-imidazolyl


5022
4-Cl
Ac
3-isoxazoyl


5023
4-Cl
Ac
3-pyrazolyl


5024
4-Cl
Ac
2-thiadiazolyl


5025
4-Cl
Ac
2-thiazolyl


5026
4-Cl
Ac
5-Ac-4-Me-2-thiazolyl


5027
4-Cl
Ac
5-tetrazolyl


5028
4-Cl
Ac
2-benzirnidazolyl


5029
4-Cl
Ac
5-benzimidazolyl


5030
4-Cl
Ac
2-benzothiazolyl


5031
4-Cl
Ac
5-benzothiazolyl


5032
4-Cl
Ac
2-benzoxazolyl


5033
4-Cl
Ac
5-benzoxazolyl


5034
4-Cl
Ac
1-adamantyl


5035
4-Cl
Ac
2-adamantyl


5036
4-Cl
Ac
i-Pr


5037
4-Cl
Ac
t-Bu


5038
4-Cl
Ac
c-Hex


5039
4-Cl
Ac
CH2CH2OMe


5040
4-Cl
Ac
CH2CONH2


5041
4-Cl
Ac
CH2CO2Me


5042
4-Cl
Ac
CH(CH2Ph)CO2Me


5043
4-Cl
Ac
CH2CH2NMe2


5044
4-Cl
Ac
benzyl


5045
4-Cl
Ac
phenethyl


5046
4-Cl
Ac
2-(morpholin-1-yl)-Et


5047
4-Cl
COtBu
Ph


5048
4-Cl
COtBu
3-CN—Ph


5049
4-Cl
COtBu
3-COMe—Ph


5050
4-Cl
COtBu
3-CO2Me—Ph


5051
4-Cl
COtBu
3-CONH2—Ph


5052
4-Cl
COtBu
3-CONHMe—Ph


5053
4-Cl
COtBu
3-F—Ph


5054
4-Cl
COtBu
3-Cl—Ph


5055
4-Cl
COtBu
3-Br—Ph


5056
4-Cl
COtBu
3-SO2NH2—Ph


5057
4-Cl
COtBu
3-SO2NHMe—Ph


5058
4-Cl
COtBu
3-CF3—Ph


5059
4-Cl
COtEu
3-OMe—Ph


5060
4-Cl
COtBu
3-SMe—Ph


5061
4-Cl
COtBu
3-SOMe—Ph


5062
4-Cl
COtBu
3-SO2Me—Ph


5063
4-Cl
COtBu
3-OH—Ph


5064
4-Cl
COtBu
3-CH2OH—Ph


5065
4-Cl
COtBu
3-CHOHMe—Ph


5066
4-Cl
COtBu
3-COH(Me)2-Ph


5067
4-Cl
COtBu
3-Me—Ph


5068
4-Cl
COtBu
3-Et—Ph


5069
4-Cl
COtBu
3-iPr—Ph


5070
4-Cl
COtBu
3-tBu—Ph


5071
4-Cl
COtBu
3-CH2CO2Me—Ph


5072
4-Cl
COtBu
3-(1-piperidinyl)-Ph


5073
4-Cl
COtBu
3-(1-pyrrolidinyl)-Ph


5074
4-Cl
COtBu
3-(2-imidazolyl)-Ph


5075
4-Cl
COtBu
3-(1-imidazolyl)-Ph


5076
4-Cl
COtBu
3-(2-thiazolyl)-Ph


5077
4-Cl
COtBu
3-(3-pyrazolyl)-Ph


5078
4-Cl
COtBu
3-(1-pyrazolyl)-Ph


5079
4-Cl
COtBu
3-(5-Me-1-tetrazolyl)-Ph


5080
4-Cl
COtBu
3-(1-Me-5-tetrazolyl)-Ph


5081
4-Cl
COtBu
3-(2-pyridyl)-Ph


5082
4-Cl
COtBu
3-(2-thienyl)-Ph


5083
4-Cl
COtBu
3-(2-furanyl)-Ph 


5084
4-Cl
COtBu
4-CN—Ph


5085
4-Cl
COtBu
4-COMe—Ph


5086
4-Cl
COtBu
4-CO2Me—Ph


5087
4-Cl
COtBu
4-CONH2—Ph


5088
4-Cl
COtBu
4-CONHMe—Ph


5089
4-Cl
COtBu
4-CONHPh—Ph


5090
4-Cl
COtBu
4-F—Ph


5091
4-Cl
COtBu
4-Cl—Ph


5092
4-Cl
COtBu
4-Br—Ph


5093
4-Cl
COtBu
4-SO2NH2—Ph


5094
4-Cl
COtBu
4-SO2NHMe—Ph


5095
4-Cl
COtBu
4-CF3—Ph


5096
4-Cl
COtBu
4-OMe—Ph


5097
4-Cl
COtBu
4-SMe—Ph


5098
4-Cl
COtBu
4-SOMe—Ph


5099
4-Cl
COtBu
4-SO2Me—Ph


5100
4-Cl
COtBu
4-OH—Ph


5101
4-Cl
COtBu
4-CH2OH—Ph


5102
4-Cl
COtBu
4-CHOHMe—Ph


5103
4-Cl
COtBu
4-COH(Me)2—Ph


5104
4-Cl
COtBu
4-Me—Ph


5105
4-Cl
COtBu
4-Et—Ph


5106
4-Cl
COtBu
4-iPr—Ph


5107
4-Cl
COtBu
4-tBu—Ph


5108
4-Cl
COtBu
4-CH2CO2Me—Ph


5109
4-Cl
COtBu
4-(1-piperidinyl)-Ph


5110
4-Cl
COtBu
4-(1-pyrrolidinyl)-Ph


5111
4-Cl
COtBu
4-(2-imidazolyl)-Ph


5112
4-Cl
COtBu
4-(1-imidazolyl)-Ph


5113
4-Cl
COtBu
4-(2-thiazolyl)-Ph


5114
4-Cl
COtBu
4-(3-pyrazolyl)-Ph


5115
4-Cl
COtBu
4-(1-pyrazolyl)-Ph


5116
4-Cl
COtBu
4-(5-Me-1-tetrazolyl)-Ph


5117
4-Cl
COtBu
4-(1-Me-5-tetrazolyl)-Ph


5118
4-Cl
COtBu
4-(2-pyridyl)-Ph


5119
4-Cl
COtBu
4-(2-thienyl)-Ph


5120
4-Cl
COtBu
4-(2-furanyl)-Ph


5121
4-Cl
COtBu
2-CN—Ph


5122
4-Cl
COtBu
2-COMe—Ph


5123
4-Cl
COtBu
2-CO2Me—Ph


5124
4-Cl
COtBu
2-CONH2—Ph


5125
4-Cl
COtBu
2-CONHMe—Ph


5126
4-Cl
COtBu
2-F—Ph


5127
4-Cl
COtBu
2-Cl—Ph


5128
4-Cl
COtBu
2-Br—Ph


5129
4-Cl
COtBu
2-SO2NH2—Ph


5130
4-Cl
COtBu
2-SO2NHMe—Ph


5131
4-Cl
COtBu
2-CF3—Ph


5132
4-Cl
COtBu
2-OMe—Ph


5133
4-Cl
COtBu
2-SMe—Ph


5134
4-Cl
COtBu
2-SOMe—Ph


5135
4-Cl
COtBu
2-SO2Me—Ph


5136
4-Cl
COtBu
2-OH—Ph


5137
4-Cl
COtBu
2-CH2OH—Ph


5138
4-Cl
COtBu
2-CHOHMe—Ph


5139
4-Cl
COtBu
2-COH(Me)2—Ph


5140
4-Cl
COtBu
2-Me—Ph


5141
4-Cl
COtBu
2-Et—Ph


5142
4-Cl
COtBu
2-iPr—Ph


5143
4-Cl
COtBu
2-tBu—Ph


5144
4-Cl
COtBu
2-CH2CO2Me—Ph


5145
4-Cl
COtBu
2-(1-piperidinyl)-Ph


5146
4-Cl
COtBu
2-(1-pyrrolidinyl)-Ph


5147
4-Cl
COtBu
2-(2-imidazolyl)-Ph


5148
4-Cl
COtBu
2-(1-imidazolyl)-Ph


5149
4-Cl
COtBu
2-(2-thiazolyl)-Ph


5150
4-Cl
COtBu
2-(3-pyrazolyl)-Ph


5151
4-Cl
COtBu
2-(1-pyrazolyl)-Ph


5152
4-Cl
COtBu
2-(5-Me-1-tetrazolyl)-Ph


5153
4-Cl
COtBu
2-(1-Me-5-tetrazolyl)-Ph


5154
4-Cl
COtBu
2-(2-pyridyl)-Ph


5155
4-Cl
COtBu
2-(2-thienyl)-Ph


5156
4-Cl
COtBu
2-(2-furanyl)-Ph


5157
4-Cl
COtBu
2,4-diF—Ph


5158
4-Cl
COtBu
2,5-diF—Ph


5159
4-Cl
COtBu
2,6-diF—Ph


5160
4-Cl
COtBu
3,4-diF—Ph


5161
4-Cl
COtBu
3,5-diF—Ph


5162
4-Cl
COtBu
2,4-diCl—Ph


5163
4-Cl
COtBu
2,5-diCl—Ph


5164
4-Cl
COtBu
2,6-diCl—Ph


5165
4-Cl
COtBu
3,4-diCl—Ph


5166
4-Cl
COtBu
3,5-diCl—Ph


5167
4-Cl
COtBu
3,4-diCF3—Ph


5168
4-Cl
COtBu
3,5-diCF3—Ph


5169
4-Cl
COtBu
5-Cl-2-MeO—Ph


5170
4-Cl
COtBu
5-Cl-2-Me—Ph


5171
4-Cl
COtBu
2-F-5-Me—Ph


5172
4-Cl
COtBu
3-F-5-morpholino-Ph


5173
4-Cl
COtBu
3,4-OCH2O—Ph


5174
4-Cl
COtBu
3,4-OCH2CH2O—Ph


5175
4-Cl
COtBu
2-MeO-5-CONH2—Ph


5176
4-Cl
COtBu
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


5177
4-Cl
COtBu
2-MeO-5-(1-Me-5-tetrazalyl)-Ph


5178
4-Cl
COtBu
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


5179
4-Cl
COtBu
1-naphthyl


5180
4-Cl
COtBu
2-naphthyl


5181
4-Cl
COtBu
2-thienyl


5182
4-Cl
COtBu
3-thienyl


5183
4-Cl
COtBu
2-furanyl


5184
4-Cl
COtBu
3-furanyl


5185
4-Cl
COtBu
2-pyridyl


5186
4-Cl
COtBu
3-pyridyl


5187
4-Cl
COtBu
4-pyridyl


5188
4-Cl
COtBu
2-indolyl


5189
4-Cl
COtBu
3-indolyl


5190
4-Cl
COtBu
5-indolyl


5191
4-Cl
COtBu
6-indolyl


5192
4-Cl
COtBu
3-indazolyl


5193
4-Cl
COtBu
5-indazolyl


5194
4-Cl
COtBu
6-indazolyl


5195
4-Cl
COtBu
2-imidazolyl


5196
4-Cl
COtBu
3-isoxazoyl


5197
4-Cl
COtBu
3-pyrazolyl


5198
4-Cl
COtBu
2-thiadiazolyl


5199
4-Cl
COtBu
2-thiazolyl


5200
4-Cl
COtBu
5-Ac-4-Me-2-thiazolyl


5201
4-Cl
COtBu
5-tetrazolyl


5202
4-Cl
COtBu
2-benzimidazolyl


5203
4-Cl
COtBu
5-benzimidazolyl


5204
4-Cl
COtBu
2-benzothiazolyl


5205
4-Cl
COtBu
5-benzothiazolyl


5206
4-Cl
COtBu
2-benzoxazolyl


5207
4-Cl
COtBu
5-benzoxazolyl


5208
4-Cl
COtBu
1-adamantyl


5209
4-Cl
COtBu
2-adamantyl


5210
4-Cl
COtBu
i-Pr


5211
4-Cl
COtBu
t-Bu


5212
4-Cl
COtBu
c-Hex


5213
4-Cl
COtBu
CH2CH2OMe


5214
4-Cl
COtBu
CH2CONH2


5215
4-Cl
COtBu
CH2CO2Me


5216
4-Cl
COtBu
CH(CH2Ph)CO2Me


5217
4-Cl
COtBu
CH2CH2NMe


5218
4-Cl
COtBu
benzyl


5219
4-Cl
COtBu
phenethyl


5220
4-Cl
COtBu
2-(morpholin-1-yl)-Et


5221
4-Cl
SO2Me
Ph


5222
4-Cl
SO2Me
3-CN—Ph


5223
4-Cl
SO2Me
3-COMe—Ph


5224
4-Cl
SO2Me
3-CO2Me—Ph


5225
4-Cl
SO2Me
3-CONH2—Ph


5226
4-Cl
SO2Me
3-CONHMe—Ph


5227
4-Cl
SO2Me
3-F—Ph


5228
4-Cl
SO2Me
3-Cl—Ph


5229
4-Cl
SO2Me
3-Br—Ph


5230
4-Cl
SO2Me
3-SO2NH2—Ph


5231
4-Cl
SO2Me
3-SO2NHMe—Ph


5232
4-Cl
SO2Me
3-CF3—Ph


5233
4-Cl
SO2Me
3-OMe—Ph


5234
4-Cl
SO2Me
3-SMe—Ph


5235
4-Cl
SO2Me
3-SOMe—Ph


5236
4-Cl
SO2Me
3-SO2Me—Ph


5237
4-Cl
SO2Me
3-OH—Ph


5238
4-Cl
SO2Me
3-CH2OH—Ph


5239
4-Cl
SO2Me
3-CHOHMe—Ph


5240
4-Cl
SO2Me
3-COH(Me)2—Ph


5241
4-Cl
SO2Me
3-Me—Ph


5242
4-Cl
SO2Me
3-Et—Ph


5243
4-Cl
SO2Me
3-iPr—Ph


5244
4-Cl
SO2Me
3-tBu—Ph


5245
4-Cl
SO2Me
3-CH2CO2Me—Ph


5246
4-Cl
SO2Me
3-(1-piperidinyl)-Ph


5247
4-Cl
SO2Me
3-(1-pyrrolidinyl)-Ph


5248
4-Cl
SO2Me
3-(2-imidazolyl)-Ph


5249
4-Cl
SO2Me
3-(1-imidazolyl)-Ph


5250
4-Cl
SO2Me
3-(2-thiazolyl)-Ph


5251
4-Cl
SO2Me
3-(3-pyrazolyl)-Ph


5252
4-Cl
SO2Me
3-(1-pyrazolyl)-Ph


5253
4-Cl
SO2Me
3-(5-Me-1-tetrazolyl)-Ph


5254
4-Cl
SO2Me
3-(1-Me-5-tetrazolyl)-Ph


5255
4-Cl
SO2Me
3-(2-pyridyl)-Ph


5256
4-Cl
SO2Me
3-(2-thienyl)-Ph


5257
4-Cl
SO2Me
3-(2-furanyl)-Ph


5258
4-Cl
SO2Me
4-CN—Ph


5259
4-Cl
SO2Me
4-COMe—Ph


5260
4-Cl
SO2Me
4-CO2Me—Ph


5261
4-Cl
SO2Me
4-CONH2—Ph


5262
4-Cl
SO2Me
4-CONHMe—Ph


5263
4-Cl
SO2Me
4-CONHPh—Ph


5264
4-Cl
SO2Me
4-F—Ph


5265
4-Cl
SO2Me
4-Cl—Ph


5266
4-Cl
SO2Me
4-Br—Ph


5267
4-Cl
SO2Me
4-SO2NH2—Ph


5268
4-Cl
SO2Me
4-SO2NHMe—Ph


5269
4-Cl
SO2Me
4-CF3—Ph


5270
4-Cl
SO2Me
4-OMe—Ph


5271
4-Cl
SO2Me
4-SMe—Ph


5272
4-Cl
SO2Me
4-SOMe—Ph


5273
4-Cl
SO2Me
4-SO2Me—Ph


5274
4-Cl
SO2Me
4-OH—Ph


5275
4-Cl
SO2Me
4-CH2OH—Ph


5276
4-Cl
SO2Me
4-CHOHMe—Ph


5277
4-Cl
SO2Me
4-COH(Me)2—Ph


5278
4-Cl
SO2Me
4-Me—Ph


5279
4-Cl
SO2Me
4-Et—Ph


5280
4-Cl
SO2Me
4-iPr—Ph


5281
4-Cl
SO2Me
4-tBu—Ph


5282
4-Cl
SO2Me
4-CH2CO2Me—Ph


5283
4-Cl
SO2Me
4-(1-piperidinyl)-Ph


5284
4-Cl
SO2Me
4-(1-pyrrolidinyl)-Ph


5285
4-Cl
SO2Me
4-(2-imidazolyl)-Ph


5286
4-Cl
SO2Me
4-(1-imidazolyl)-Ph


5287
4-Cl
SO2Me
4-(2-thiazolyl)-Ph


5288
4-Cl
SO2Me
4-(3-pyrazolyl)-Ph


5289
4-Cl
SO2Me
4-(1-pyrazolyl)-Ph


5290
4-Cl
SO2Me
4-(5-Me-1-tetrazolyl)-Ph


5291
4-Cl
SO2Me
4-(1-Me-5-tetrazolyl)-Ph


5292
4-Cl
SO2Me
4-(2-pyridyl)-Ph


5293
4-Cl
SO2Me
4-(2-thienyl)-Ph


5294
4-Cl
SO2Me
4-(2-furanyl)-Ph


5295
4-Cl
SO2Me
2-CN—Ph


5296
4-Cl
SO2Me
2-COMe—Ph


5297
4-Cl
SO2Me
2-CO2Me—Ph


5298
4-Cl
SO2Me
2-CONH2—Ph


5299
4-Cl
SO2Me
2-CONHMe—Ph


5300
4-Cl
SO2Me
2-F—Ph


5301
4-Cl
SO2Me
2-Cl—Ph


5302
4-Cl
SO2Me
2-Br—Ph


5303
4-Cl
SO2Me
2-SO2NH2—Ph


5304
4-Cl
SO2Me
2-SO2NHMe—Ph


5305
4-Cl
SO2Me
2-CF3—Ph


5306
4-Cl
SO2Me
2-OMe—Ph


5307
4-Cl
SO2Me
2-SMe—Ph


5308
4-Cl
SO2Me
2-SOMe—Ph


5309
4-Cl
SO2Me
2-SO2Me—Ph


5310
4-Cl
SO2Me
2-OH—Ph


5311
4-Cl
SO2Me
2-CH2OH—Ph


5312
4-Cl
SO2Me
2-CHOHMe—Ph


5313
4-Cl
SO2Me
2-COH(Ne)2—Ph


5314
4-Cl
SO2Me
2-2-Me—Ph


5315
4-Cl
SO2Me
2-Et—Ph


5316
4-Cl
SO2Me
2-iPr—Ph


5317
4-Cl
SO2Me
2-tBu—Ph


5318
4-Cl
SO2Me
2-CH2CO2Me—Ph


5319
4-Cl
SO2Me
2-(1-piperidinyl)-Ph


5320
4-Cl
SO2Me
2-(1-pyrrolidinyl)-Ph


5321
4-Cl
SO2Me
2-(2-imidazolyl)-Ph


5322
4-Cl
SO2Me
2-(1-imidazolyl)-Ph


5323
4-Cl
SO2Me
2-(2-thiazolyl)-Ph


5324
4-Cl
SO2Me
2-(3-pyrazolyl)-Ph


5325
4-Cl
SO2Me
2-(1-pyrazolyl)-Ph


5326
4-Cl
SO2Me
2-(5-Me-1-tetrazolyl)-Ph


5327
4-Cl
SO2Me
2-(1-Me-5-tetrazolyl)-Ph


5328
4-Cl
SO2Me
2-(2-pyridyl)-Ph


5329
4-Cl
SO2Me
2-(2-thienyl)-Ph


5330
4-Cl
SO2Me
2-(2-furanyl)-Ph


5331
4-Cl
SO2Me
2,4-diF—Ph


5332
4-Cl
SO2Me
2,5-diF—Ph


5333
4-Cl
SO2Me
2,6-diF—Ph


5334
4-Cl
SO2Me
3,4-diF—Ph


5335
4-Cl
SO2Me
3,5-diF—Ph


5336
4-Cl
SO2Me
2,4-diCl—Ph


5337
4-Cl
SO2Me
2,5-diCl—Ph


5338
4-Cl
SO2Me
2,6-diCl—Ph


5339
4-Cl
SO2Me
3,4-diCl—Ph


5340
4-Cl
SO2Me
3,5-diCl—Ph


5341
4-Cl
SO2Me
3,4-diCF3—Ph


5342
4-Cl
SO2Me
3,5-diCF3—Ph


5343
4-Cl
SO2Me
5-Cl-2-MeO—Ph


5344
4-Cl
SO2Me
5-Cl-2-Me—Ph


5345
4-Cl
SO2Me
2-F-5-Me—Ph


5346
4-Cl
SO2Me
3-F-5-morpholino-Ph


5347
4-Cl
SO2Me
3,4-OCH2O—Ph


5348
4-Cl
SO2Me
3,4-OCH2CH2O—Ph


5349
4-Cl
SO2Me
2-MeO-5-CONH2—Ph


5350
4-Cl
SO2Me
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


5351
4-Cl
SO2Me
2-MeO-5-(1-Me-5-tetrazolyl)-Ph


5352
4-Cl
SO2Me
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


5353
4-Cl
SO2Me
1-naphthyl


5354
4-Cl
SO2Me
2-naphthyl


5355
4-Cl
SO2Me
2-thienyl


5356
4-Cl
SO2Me
3-thienyl


5357
4-Cl
SO2Me
2-furanyl


5358
4-Cl
SO2Me
3-furanyl


5359
4-Cl
SO2Me
2-pyridyl


5360
4-Cl
SO2Me
3-pyridyl


5361
4-Cl
SO2Me
4-pyridyl


5362
4-Cl
SO2Me
2-indolyl


5363
4-Cl
SO2Me
3-indolyl


5364
4-Cl
SO2Me
5-indolyl


5365
4-Cl
SO2Me
6-indolyl


5366
4-Cl
SO2Me
3-indazolyl


5367
4-Cl
SO2Me
5-indazolyl


5368
4-Cl
SO2Me
6-indazolyl


5369
4-Cl
SO2Me
2-imidazolyl


5370
4-Cl
SO2Me
3-isoxazoyl


5371
4-Cl
SO2Me
3-pyrazolyl


5372
4-Cl
SO2Me
2-thiadiazolyl


5373
4-Cl
SO2Me
2-thiazolyl


5374
4-Cl
SO2Me
5-Ac-4-Me-2-thiazolyl


5375
4-Cl
SO2Me
5-tetrazolyl


5376
4-Cl
SO2Me
2-benzimidazolyl


5377
4-Cl
SO2Me
5-benzimidazolyl


5378
4-Cl
SO2Me
2-benzothiazolyl


5379
4-Cl
SO2Me
5-benzothiazolyl


5380
4-Cl
SO2Me
2-benzoxazolyl


5381
4-Cl
SO2Me
5-benzoxazolyl


5382
4-Cl
SO2Me
1-adamantyl


5383
4-Cl
SO2Me
2-adamantyl


5384
4-Cl
SO2Me
i-Pr


5385
4-Cl
SO2Me
t-Bu


5386
4-Cl
SO2Me
c-Hex


5387
4-Cl
SO2Me
CH2CH2OMe


5388
4-Cl
SO2Me
CH2CONH2


5389
4-Cl
SO2Me
CH2CO2Me


5390
4-Cl
SO2Me
CH(CH2Ph)CO2Me


5391
4-Cl
SO2Me
CH2CH2NMe2


5392
4-Cl
SO2Me
benzyl


5393
4-Cl
SO2Me
phenethyl


5394
4-Cl
SO2Me
2-(morpholin-1-yl)-Et


5395
4-Cl
CH2COMe
Ph


5396
4-Cl
CH2COMe
3-CN—Ph


5397
4-Cl
CH2COMe
3-COMe—Ph


5398
4-Cl
CH2COMe
3-CO2Me—Ph


5399
4-Cl
CH2COMe
3-CONH2—Ph


5400
4-Cl
CH2COMe
3-CONHMe—Ph


5401
4-Cl
CH2COMe
3-F—Ph


5402
4-Cl
CH2COMe
3-Cl—Ph


5403
4-Cl
CH2COMe
3-Br—Ph


5404
4-Cl
CH2COMe
3-SO2NH2—Ph


5405
4-Cl
CH2COMe
3-SO2NHMe—Ph


5406
4-Cl
CH2COMe
3-CF3—Ph


5407
4-Cl
CH2COMe
3-OMe—Ph


5408
4-Cl
CH2COMe
3-SMe—Ph


5409
4-Cl
CH2COMe
3-SOMe—Ph


5410
4-Cl
CH2COMe
3-SO2Me—Ph


5411
4-Cl
CH2COMe
3-OH—Ph


5412
4-Cl
CH2COMe
3-CH2OH—Ph


5413
4-Cl
CH2COMe
3-CHOHMe—Ph


5414
4-Cl
CH2COMe
3-COH(Me)2—Ph


5415
4-Cl
CH2COMe
3-Me—Ph


5416
4-Cl
CH2COMe
3-Et—Ph


5417
4-Cl
CH2COMe
3-iPr—Ph


5418
4-Cl
CH2COMe
3-tBu—Ph


5419
4-Cl
CH2COMe
3-CH2CO2Me—Ph


5420
4-Cl
CH2COMe
3-(1-piperidinyl)-Ph


5421
4-Cl
CH2COMe
3-(1-pyrrolidinyl)-Ph


5422
4-Cl
CH2COMe
3-(2-imidazolyl)-Ph


5423
4-Cl
CH2COMe
3-(1-imidazolyl)-Ph


5424
4-Cl
CH2COMe
3-(2-thiazolyl)-Ph


5425
4-Cl
CH2COMe
3-(3-pyrazolyl)-Ph


5426
4-Cl
CH2COMe
3-(1-pyrazolyl)-Ph


5427
4-Cl
CH2COMe
3-(5-Me-1-tetrazolyl)-Ph


5428
4-Cl
CH2COMe
3-(1-Me-5-tetrazolyl)-Ph


5429
4-Cl
CH2COMe
3-(2-pyridyl)-Ph


5430
4-Cl
CH2COMe
3-(2-thienyl)-Ph


5431
4-Cl
CH2COMe
3-(2-furanyl)-Ph


5432
4-Cl
CH2COMe
4-CN—Ph


5433
4-Cl
CH2COMe
4-COMe—Ph


5434
4-Cl
CH2COMe
4-CO2Me—Ph


5435
4-Cl
CH2COMe
4-CONH2—Ph


5436
4-Cl
CH2COMe
4-CONHMe—Ph


5437
4-Cl
CH2COMe
4-CONHPh—Ph


5438
4-Cl
CH2COMe
4-F—Ph


5439
4-Cl
CH2COMe
4-Cl—Ph


5440
4-Cl
CH2COMe
4-Br—Ph


5441
4-Cl
CH2COMe
4-SO2NH2—Ph


5442
4-Cl
CH2COMe
4-SO2NHMe—Ph


5443
4-Cl
CH2COMe
4-CF3—Ph


5444
4-Cl
CH2COMe
4-OMe—Ph


5445
4-Cl
CH2COMe
4-SMe—Ph


5446
4-Cl
CH2COMe
4-SOMe—Ph


5447
4-Cl
CH2COMe
4-SO2Me—Ph


5448
4-Cl
CH2COMe
4-OH—Ph


5449
4-Cl
CH2COMe
4-CH2OH—Ph


5450
4-Cl
CH2COMe
4-CHOHMe—Ph


5451
4-Cl
CH2COMe
4-COH(Me)2—Ph


5452
4-Cl
CH2COMe
4-Me—Ph


5453
4-Cl
CH2COMe
4-Et—Ph


5454
4-Cl
CH2COMe
4-iPr—Ph


5455
4-Cl
CH2COMe
4-tBu—Ph


5456
4-Cl
CH2COMe
4-CH2CO2Me—Ph


5457
4-Cl
CH2COMe
4-(1-piperidinyl)-Ph


5458
4-Cl
CH2COMe
4-(1-pyrrolidinyl)-Ph


5459
4-Cl
CH2COMe
4-(2-imidazolyl)-Ph


5460
4-Cl
CH2COMe
4-(1-imidazolyl)-Ph


5461
4-Cl
CH2COMe
4-(2-thiazolyl)-Ph


5462
4-Cl
CH2COMe
4-(3-pyrazolyl)-Ph


5463
4-Cl
CH2COMe
4-(1-pyrazolyl)-Ph


5464
4-Cl
CH2COMe
4-(5-Me-1-tetrazolyl)-Ph


5465
4-Cl
CH2COMe
4-(1-Me-5-tetrazolyl)-Ph


5466
4-Cl
CH2COMe
4-(2-pyridyl)-Ph


5467
4-Cl
CH2COMe
4-(2-thienyl)-Ph


5468
4-Cl
CH2COMe
4-(2-furanyl)-Ph


5469
4-Cl
CH2COMe
2-CN—Ph


5470
4-Cl
CH2COMe
2-COMe—Ph


5471
4-Cl
CH2COMe
2-CO2Me—Ph


5472
4-Cl
CH2COMe
2-CONH2—Ph


5473
4-Cl
CH2COMe
2-CONHMe—Ph


5474
4-Cl
CH2COMe
2-F—Ph


5475
4-Cl
CH2COMe
2-Cl—Ph


5476
4-Cl
CH2COMe
2-Br—Ph


5477
4-Cl
CH2COMe
2-SO2NH2—Ph


5478
4-Cl
CH2COMe
2-SO2NHMe—Ph


5479
4-Cl
CH2COMe
2-CF3—Ph


5480
4-Cl
CH2COMe
2-OMe—Ph


5481
4-Cl
CH2COMe
2-SMe—Ph


5482
4-Cl
CH2COMe
2-SOMe—Ph


5483
4-Cl
CH2COMe
2-SO2Me—Ph


5484
4-Cl
CH2COMe
2-OH—Ph


5485
4-Cl
CH2COMe
2-CH2OH—Ph


5486
4-Cl
CH2COMe
2-CHOHMe—Ph


5487
4-Cl
CH2COMe
2-COH(Me)2—Ph


5488
4-Cl
CH2COMe
2-Me—Ph


5489
4-Cl
CH2COMe
2-Et—Ph


5490
4-Cl
CH2COMe
2-iPr-Ph


5491
4-Cl
CH2COMe
2-tBu—Ph


5492
4-Cl
CH2COMe
2-CH2CO2Me—Ph


5493
4-Cl
CH2COMe
2-(1-piperidinyl)-Ph


5494
4-Cl
CH2COMe
2-(1-pyrrolidinyl)-Ph


5495
4-Cl
CH2COMe
2-(2-imidazolyl)-Ph


5496
4-Cl
CH2COMe
2-(1-imidazolyl)-Ph


5497
4-Cl
CH2COMe
2-(2-thiazolyl)-Ph


5498
4-Cl
CH2COMe
2-(3-pyrazolyl)-Ph


5499
4-Cl
CH2COMe
2-(1-pyrazolyl)-Ph


5500
4-Cl
CH2COMe
2-(5-Me-1-tetrazolyl)-Ph


5501
4-Cl
CH2COMe
2-(1-Me-5-tetrazolyl)-Ph


5502
4-Cl
CH2COMe
2-(2-pyridyl)-Ph


5503
4-Cl
CH2COMe
2-(2-thienyl)-Ph


5504
4-Cl
CH2COMe
2-(2-furanyl)-Ph


5505
4-Cl
CH2COMe
2,4-diF—Ph


5506
4-Cl
CH2COMe
2,5-diF—Ph


5507
4-Cl
CH2COMe
2,6-diF—Ph


5508
4-Cl
CH2COMe
3,4-diF—Ph


5509
4-Cl
CH2COMe
3,5-diF—Ph


5510
4-Cl
CH2COMe
2,4-diCl—Ph


5511
4-Cl
CH2COMe
2,5-diCl—Ph


5512
4-Cl
CH2COMe
2,6-diCl—Ph


5513
4-Cl
CH2COMe
3,4-diCl—Ph


5514
4-Cl
CH2COMe
3,5-diCl—Ph


5515
4-Cl
CH2COMe
3,4-diCF3—Ph


5516
4-Cl
CH2COMe
3,5-diCF3—Ph


5517
4-Cl
CH2COMe
5-Cl-2-MeO—Ph


5518
4-Cl
CH2COMe
5-Cl-2-Me—Ph


5519
4-Cl
CH2COMe
2-F-5-Me—Ph


5520
4-Cl
CH2COMe
3-F-5-morpholino-Ph


5521
4-Cl
CH2COMe
3,4-OCH2O—Ph


5522
4-Cl
CH2COMe
3,4-OCH2CH2O—Ph


5523
4-Cl
CH2COMe
2-MeO-5-CONH2—Ph


5524
4-Cl
CH2COMe
2-MeO-4-(1-Me-5-tetrazolyl)-Ph


5525
4-Cl
CH2COMe
2-MeO-5-(1-Me-5-tetrazolyl)-Ph


5526
4-Cl
CH2COMe
3-CONH2-5-(1-Me-5-tetrazolyl)-Ph


5527
4-Cl
CH2COMe
1-naphthyl


5528
4-Cl
CH2COMe
2-naphthyl


5529
4-Cl
CH2COMe
2-thienyl


5530
4-Cl
CH2COMe
3-thienyl


5531
4-Cl
CH2COMe
2-furanyl


5532
4-Cl
CH2COMe
3-furanyl


5533
4-Cl
CH2COMe
2-pyridyl


5534
4-Cl
CH2COMe
3-pyridyl


5535
4-Cl
CH2COMe
4-pyridyl


5536
4-Cl
CH2COMe
2-indolyl


5537
4-Cl
CH2COMe
3-indolyl


5538
4-Cl
CH2COMe
5-indolyl


5539
4-Cl
CH2COMe
6-indolyl


5540
4-Cl
CH2COMe
3-indazolyl


5541
4-Cl
CH2COMe
5-indazolyl


5542
4-Cl
CH2COMe
6-indazolyl


5543
4-Cl
CH2COMe
2-imidazolyl


5544
4-Cl
CH2COMe
3-isoxazoyl


5545
4-Cl
CH2COMe
3-pyrazolyl


5546
4-Cl
CH2COMe
2-thiadiazolyl


5547
4-Cl
CH2COMe
2-thiazolyl


5548
4-Cl
CH2COMe
5-Ac-4-Me-2-thiazolyl


5549
4-Cl
CH2COMe
5-tetrazolyl


5550
4-Cl
CH2COMe
2-benzimidazolyl


5551
4-Cl
CH2COMe
5-benzimidazolyl


5552
4-Cl
CH2COMe
2-benzothiazolyl


5553
4-Cl
CH2COMe
5-benzothiazolyl


5554
4-Cl
CH2COMe
2-benzoxazolyl


5555
4-Cl
CH2COMe
5-benzoxazolyl


5556
4-Cl
CH2COMe
1-adamantyl


5557
4-Cl
CH2COMe
2-adamantyl


5558
4-Cl
CH2COMe
i-Pr


5559
4-Cl
CH2COMe
t-Bu


5560
4-Cl
CH2COMe
c-Hex


5561
4-Cl
CH2COMe
CH2CH2OMe


5562
4-Cl
CH2COMe
CH2CONH2


5563
4-Cl
CH2COMe
CH2CO2Me


5564
4-Cl
CH2COMe
CH(CH2Ph)CO2Me


5565
4-Cl
CH2COMe
CH2CH2NMe2


5566
4-Cl
CH2COMe
benzyl


5567
4-Cl
CH2COMe
phenethyl


5568
4-Cl
CH2COMe
2-(morpholin-1-yl)-Et
















TABLE 3














13









14









15









16









17









18









19









20









21









22









23









24









25









26









27









28









29









30









31









32









33









34









35









36









37









38









39









40









41









42









43









44









45









46





























































































Entry
R16
R3





1
2-F
Ph


2
2-F
3-CN—Ph


3
2-F
3-COMe—Ph


4
2-F
3-CO2Me—Ph


5
2-F
3-CONH2—Ph


6
2-F
3-CONHMe—Ph


7
2-F
3-F—Ph


8
2-F
3-Cl—Ph


9
2-F
3-Br—Ph


10
2-F
3-SO2NH2—Ph


11
2-F
3-SO2NHMe—Ph


12
2-F
3-CF3—Ph


13
2-F
3-ONe—Ph


14
2-F
3-SMe—Ph


15
2-F
3-SOMe—Ph


16
2-F
3-SO2OH—Ph


17
2-F
3-OH—Ph


18
2-F
3-CH2OH—Ph


19
2-F
3-CHOHMe—Ph


20
2-F
3-COH(Me)2—Ph


21
2-F
3-Me—Ph


22
2-F
3-Et—Ph


23
2-F
3-iPr—Ph


24
2-F
3-tBu—Ph


25
2-F
3 -CH2CO2Me—Ph


26
2-F
3-(1-piperidinyl)—Ph


27
2-F
3-(1-pyrrolidinyl)—Ph


28
2-F
3-(2-imidazolyl)—Ph


29
2-F
3-(1-imidazolyl)—Ph


30
2-F
3-(2-thiazolyl)—Ph


31
2-F
3-(3-pyrazolyl)—Ph


32
2-F
3-(1-pyrazolyl)—Ph


33
2-F
3-(5-Me-1-tetrazolyl)—Ph


34
2-F
3-(1-Me-5-tetrazolyl)—Ph


35
2-F
3-(2-pyridyl)—Ph


36
2-F
3-(2-thienyl)—Ph


37
2-F
3-(2-furanyl)—Ph


38
2-F
4-CN—Ph


39
2-F
4-COMe—Ph


40
2-F
4-CO2Me—Ph


41
2-F
4-CONH2—Ph


42
2-F
4-CONIIMe—Ph


43
2-F
4-CONHPh—Ph


44
2-F
4-F—Ph


45
2-F
4-Cl—Ph


46
2-F
4-Br—Ph


47
2-F
4-SO2NH2—Ph


48
2-F
4-SO2NHMe—Ph


49
2-F
4-CF3—Ph


50
2-F
4-OMe—Ph


51
2-F
4-SMe—Ph


52
2-F
4-SOMe—Ph


53
2-F
4-SO2Me—Ph


54
2-F
4-OH—Ph


55
2-F
4-CH2OH—Ph


56
2-F
4-CHOHMe—Ph


57
2-F
4-COH(Me)2—Ph


58
2-F
4-Me—Ph


59
2-F
4-Et—Ph


60
2-F
4-iPr—Ph


61
2-F
4-tBu—Ph


62
2-F
4-CH2CO2Me—Ph


63
2-F
4-(1-piperidinyl)—Ph


64
2-F
4-(1-pyrrolidinyl)—Ph


65
2-F
4-(2-imidazolyl)—Ph


66
2-F
4-(1-imidazolyl)—Ph


67
2-F
4-(2-thiazolyl)—Ph


68
2-F
4-(3-pyrazolyl)—Ph


69
2-F
4-(1-pyrazolyl)—Ph


70
2-F
4-(5-Me-1-tetrazolyl)—Ph


71
2-F
4-(1-Me-5-tetrazolyl)—Ph


72
2-F
4-(2-pyridyl)—Ph


73
2-F
4-(2-thieny1)—Ph


74
2-F
4-(2-furanyl)—Ph


75
2-F
2-CN—Ph


76
2-F
2-COMe—Ph


77
2-F
2-CO2Me—Ph


78
2-F
2-CONH2—Ph


79
2-F
2-CONHMe—Ph


80
2-F
2-F—Ph


81
2-F
2-Cl—Ph


82
2-F
2-Br—Ph


83
2-F
2-SO2NH2—Ph


84
2-F
2-SO2NHMe—Ph


85
2-F
2-CF3—Ph


86
2-F
2-OMe—Ph


87
2-F
2-SMe—Ph


88
2-F
2-SOMe—Ph


89
2-F
2-SO2Me—Ph


90
2-F
2-OH—Ph


91
2-F
2-CH2OH—Ph


92
2-F
2-CHOlINe—Ph


93
2-F
2-COH(Me)2—Ph


94
2-F
2-Me—Ph


95
2-F
2-Et—Ph


96
2-F
2-iPr—Ph


97
2-F
2-tBu—Ph


98
2-F
2-CH2CO2Me—Ph


99
2-F
2-(1-piperidinyl)—Ph


100
2-F
2-(1-pyrrolidinyl)—Ph


101
2-F
2-(2-imidazolyl)—Ph


102
2-F
2-(1-imidazolyi)—Ph


103
2-F
2-(2-thiazolyl)—Ph


104
2-F
2-(3-pyrazolyl)—Ph


105
2-F
2-(1-pyrazolyl)—Ph


106
2-F
2-(5-Me-1-tetrazol 1)—Ph


107
2-F
2-(1-Me-5-tetrazolyl)—Ph


108
2-F
2-(2-pyridyl)—Ph


109
2-F
2-(2-thienyl)—Ph


110
2-F
2-(2-furanyl)—Ph


111
2-F
2,4-diF—Ph


112
2-F
2,5-diF—Ph


113
2-F
2,6-diF—Ph


114
2-F
3,4-diF—Ph


115
2-F
3,5-diF—Ph


116
2-F
2,4-diCl—Ph


117
2-F
2,5-diCl—Ph


118
2-F
2,6-diCl—Ph


119
2-F
3,4-diCl—Ph


120
2-F
3,5-diCl—Ph


121
2-F
3,4-diCF3—Ph


122
2-F
3,5-diCF3—Ph


123
2-F
5-Cl-2-MeO—Ph


124
2-F
5-Cl-2-Me—Ph


125
2-F
2-F-S-Me—Ph


126
2-F
3-F-5-morpholino—Ph


127
2-F
3,4-OCH2O—Ph


128
2-F
3,4-OCH2CH2O—Ph


129
2-F
2-MeO-5-CONH2—Ph


130
2-F
2-MeO-4-(1-Me-5-tetrazol 1)—Ph


131
2-F
2-MeO-5-(1-Me-5-tetrazolyl)—Ph


132
2-F
3-CONH2-5-(1-Me-5-tetrazolyl)—Ph


133
2-F
1-naphthyl


134
2-F
2-naphthyl


135
2-F
2-thienyl


136
2-F
3-thienyl


137
2-F
2-furanyl


138
2-F
3-furanyl


139
2-F
2-pyridyl


140
2-F
3-pyridyl


141
2-F
4-pyridyl


142
2-F
2-indolyl


143
2-F
3-indolyl


144
2-F
5-indolyl


145
2-F
6-indolyl


146
2-F
3-indazolyl


147
2-F
5-indazolyl


148
2-F
6-indazolyl


149
2-F
2-imidazolyl


150
2-F
3-isoxazoyl


151
2-F
3-pyrazolyl


152
2-F
2-thiadiazolyl


153
2-F
2-thiazolyl


154
2-F
5-Ac-4-Me-2-thiazolyl


155
2-F
5-tetrazolyl


156
2-F
2-benzimidazolyl


157
2-F
5-benzimidazolyl


158
2-F
2-benzothiazolyl


159
2-F
5-benzothiazolyl


160
2-F
2-benzoxazolyl


161
2-F
5-benzoxazolyl


162
2-F
1-adamantyl


163
2-F
2-adamantyl


164
2-F
i-Pr


165
2-F
t-Bu


166
2-F
c-Hex


167
2-F
CH2CH2OMe


168
2-F
CH2CONH2


169
2-F
CH2CO2Me


170
2-F
CH(CH2Ph)CO2Me


171
2-F
CH2CH2NMe2


172
2-F
benzyl


173
2-F
phenethyl


174
2-F
2-(morpholin-1-yl)-Et


175
3-F
Ph


176
3-F
3-CN—Ph


177
3-F
3-COMe—Ph


178
3-F
3-CO2Me—Ph


179
3-F
3-CONH2—Ph


180
3-F
3-CONHMe—Ph


181
3-F
3-F—Ph


182
3-F
3-Cl—Ph


183
3-F
3-Br—Ph


184
3-F
3-SO2NH2—Ph


185
3-F
3-SO2NHMe—Ph


186
3-F
3-CF3—Ph


187
3-F
3-OMe—Ph


188
3-F
3-SMe—Ph


189
3-F
3-SOMe—Ph


190
3-F
3-SO2Me—Ph


191
3-F
3-OH—Ph


192
3-F
3-CH2OH—Ph


193
3-F
3-CHOHMe—Ph


194
3-F
3-COH(Me)2—Ph


195
3-F
3-Me—Ph


196
3-F
3-Et—Ph


197
3-F
3-iPr—Ph


198
3-F
3-tBu—Ph


199
3-F
3-CH2CO2Me—Ph


200
3-F
3-(1-piperidinyl)—Ph


201
3-F
3-(1-pyrrolidinyl)—Ph


202
3-F
3-(2-imidazolyl)—Ph


203
3-F
3-(1-imidazolyl)—Ph


204
3-F
3-(2-thiazolyl)—Ph


205
3-F
3-(3-pyrazolyl)—Ph


206
3-F
3-(1-pyrazolyl)—Ph


207
3-F
3-(5-Me-1-tetrazolyl)—Ph


208
3-F
3-(1-Me-5-tetrazolyl)—Ph


209
3-F
3-(2-pyrid 1)—Ph


210
3-F
3-(2-thienyl)—Ph


211
3-F
3-(2-furanyl)—Ph


212
3-F
4-CN—Ph


213
3-F
4-COMe—Ph


214
3-F
4-CO2Me—Ph


215
3-F
4-CONH2—Ph


216
3-F
4-CONHMe—Ph


217
3-F
4-CONHPh—Ph


218
3-F
4-F—Ph


219
3-F
4-Cl—Ph


220
3-F
4-Br—Ph


221
3-F
4-SO2NH2—Ph


222
3-F
4-SO2NHMe—Ph


223
3-F
4-CF3—Ph


224
3-F
4-OMe—Ph


225
3-F
4-SMe—Ph


226
3-F
4-SOMe—Ph


227
3-F
4-SO2Me—Ph


228
3-F
4-OH—Ph


229
3-F
4-CH2OH—Ph


230
3-F
4-CHOHMe—Ph


231
3-F
4-COH(Me)2—Ph


232
3-F
4-Me—Ph


233
3-F
4-Et—Ph


234
3-F
4-iPr—Ph


235
3-F
4-t.Bu—Ph


236
3-F
4-CH2CO2Me—Ph


237
3-F
4-(1-piperidinyl)—Ph


238
3-F
4-(1-pyrrolidinyl)—Ph


239
3-F
4-(2-imidazolyl)—Ph


240
3-F
4-(1-imidazolyl)—Ph


241
3-F
4-(2-thiazolyl)—Ph


242
3-F
4-(3-pyrazolyl)—Ph


243
3-F
4-(1-pyrazolyl)—Ph


244
3-F
4-(5-Me-1-tetrazolyl)—Ph


245
3-F
4-(1-Me-5-tetrazolyl)—Ph


246
3-F
4-(2-pyridyl)—Ph


247
3-F
4-(2-thienyl)—Ph


248
3-F
4-(2-furanyl)—Ph


249
3-F
2-CN—Ph


250
3-F
2-COMe—Ph


251
3-F
2-CO2Me—Ph


252
3-F
2-CONH2—Ph


253
3-F
2-CONHMe—Ph


254
3-F
2-F—Ph


255
3-F
2-Cl—Ph


256
3-F
2-Br—Ph


257
3-F
2-SO2NH2—Ph


258
3-F
2-SO2NHMe—Ph


259
3-F
2-CF3—Ph


260
3-F
2-OMe—Ph


261
3-F
2-SMe—Ph


262
3-F
2-SOMe—Ph


263
3-F
2-SO2Me—Ph


264
3-F
2-OH—Ph


265
3-F
2-CH2OH—Ph


266
3-F
2-CHOHMe—Ph


267
3-F
2-COH(Me)2—Ph


268
3-F
2-Me—Ph


269
3-F
2-Et—Ph


270
3-F
2-iPr—Ph


271
3-F
2-tBu—Ph


272
3-F
2-CH2CO2Me—Ph


273
3-F
2-(1-piperidinyl)—Ph


274
3-F
2-(1-pyrrolidinyl)—Ph


275
3-F
2-(2-imidazolyl)—Ph


276
3-F
2-(1-imidazolyi)—Ph


277
3-F
2-(2-thiazolyl)—Ph


278
3-F
2-(3-pyrazolyl)—Ph


279
3-F
2-(1-pyrazolyl)—Ph


280
3-F
2-(5-Me-1-tetrazolyl)—Ph


281
3-F
2-(1-Me-5-tetrazolyl)—Ph


282
3-F
2-(2-pyridyl)—Ph


283
3-F
2-(2-thienyl)—Ph


284
3-F
2-(2-furanyl)—Ph


285
3-F
2,4-diF—Ph


286
3-F
2,5-diF—Ph


287
3-F
2,6-diF—Ph


288
3-F
3,4-diF—Ph


289
3-F
3,5-diF—Ph


290
3-F
2,4-diCl—Ph


291
3-F
2,5-diCl—Ph


292
3-F
2,6-diCl—Ph


293
3-F
3,4-diCl—Ph


294
3-F
3,5-diCl—Ph


295
3-F
3,4-diCF3—Ph


296
3-F
3,5-diCF3—Ph


297
3-F
5-Cl-2-MeO—Ph


298
3-F
5-Cl-2-Me—Ph


299
3-F
2-F-5-Me—Ph


300
3-F
3-F-5-morpholino—Ph


301
3-F
3,4-OCH2O—Ph


302
3-F
3,4-OCH2CH2O—Ph


303
3-F
2-MeO-5-CONH2—Ph


304
3-F
2-MeO-4-(1-Me-5-tetrazolyl)—Ph


305
3-F
2-MeO-5-(1-Me-5-tetrazolyl)—Ph


306
3-F
3-CONH2-5-(1-Me-5-tetrazolyl)—Ph


307
3-F
1-naphthyl


308
3-F
2-naphthyl


309
3-F
2-thienyl


310
3-F
3-thienyl


311
3-F
2-furanyl


312
3-F
3-furanyl


313
3-F
2-pyridyl


314
3-F
3-pyridyl


315
3-F
4-pyridyl


316
3-F
2-indolyl


317
3-F
3-indolyl


318
3-F
5-indolyl


319
3-F
6-indolyl


320
3-F
3-indazolyl


321
3-F
5-indazolyl


322
3-F
6-indazolyl


323
3-F
2-imidazolyl


324
3-F
3-isoxazoyl


325
3-F
3-pyrazolyl


326
3-F
2-thiadiazolyl


327
3-F
2-thiazolyl


328
3-F
5-Ac-4-Me-2-thiazolyl


329
3-F
5-tetrazolyl


330
3-F
2-benzimidazolyl


331
3-F
5-benzimidazoly


332
3-F
2-benzothiazolyl


333
3-F
5-benzothiazolyl


334
3-F
2-benzoxazolyl


335
3-F
5-benzoxazolyl


336
3-F
1-adamantyl


337
3-F
2-adamantyl


338
3-F
i-Pr


339
3-F
t-Bu


340
3-F
c-Hex


341
3-F
CH2CH2OMe


342
3-F
CH2CONH2


343
3-F
CH2CO2Me


344
3-F
CH(CH2Ph)CO2Ne


345
3-F
CH2CH2NMe2


346
3-F
benzyl


347
3-F
phenethyl


348
3-F
2-(morpholin-1-yl)-Et


349
4-F
Ph


350
4-F
3-CN—Ph


351
4-F
3-COMe—Ph


352
4-F
3-CO2Me—Ph


353
4-F
3-CONH2—Ph


354
4-F
3-CONHMe—Ph


355
4-F
3-F—Ph


356
4-F
3-Cl—Ph


357
4-F
3-Br—Ph


358
4-F
3-SO2NH2—Ph


359
4-F
3-SO2NHMe—Ph


360
4-F
3-CF3—Ph


361
4-F
3-OMe—Ph


362
4-F
3-SMe—Ph


363
4-F
3-SOMe—Ph


364
4-F
3-SO2Me—Ph


365
4-F
3-OH—Ph


366
4-F
3-CH2OH—Ph


367
4-F
3-CHOHMe—Ph


368
4-F
3-COH(Me)2—Ph


369
4-F
3-Me—Ph


370
4-F
3-Et—Ph


371
4-F
3-iPr—Ph


372
4-F
3-tBu—Ph


373
4-F
3-CH2CO2Me—Ph


374
4-F
3-(1-piperidinyl)—Ph


375
4-F
3-(1-pyrrolidinyl)—Ph


376
4-F
3-(2-imidazolyl)—Ph


377
4-F
3-(1-imidazolyl)—Ph


378
4-F
3-(2-thiazolyl)—Ph


379
4-F
3-(3-pyrazolyl)—Ph


380
4-F
3-(1-pyrazolyl)—Ph


381
4-F
3-(5-Me-1-tetrazolyl)—Ph


382
4-F
3-(1-Me-5-tetrazolyl)—Ph


383
4-F
3-(2-pyridyl)—Ph


384
4-F
3-(2-thienyl)—Ph


385
4-F
3-(2-furanyl)—Ph


386
4-F
4-CN—Ph


387
4-F
4-COMe—Ph


388
4-F
4-CO2Me—Ph


389
4-F
4-CONH2—Ph


390
4-F
4-CONHMe—Ph


391
4-F
4-CONHPh—Ph


392
4-F
4-F—Ph


393
4-F
4-Cl—Ph


394
4-F
4-Br—Ph


395
4-F
4-SO2NH2—Ph


396
4-F
4-SO2NHMe—Ph


397
4-F
4-CF3—Ph


398
4-F
4-ONe—Ph


399
4-F
4-SMe—Ph


400
4-F
4-SOMe—Ph


401
4-F
4-SO2Me—Ph


402
4-F
4-OH—Ph


403
4-F
4-CH2OH—Ph


404
4-F
4-CHOHMe—Ph


405
4-F
4-COH(Me)2—Ph


406
4-F
4-Me—Ph


407
4-F
4-Et—Ph


408
4-F
4-iPr—Ph


409
4-F
4-tBu—Ph


410
4-F
4-CH2CO2Me—Ph


411
4-F
4-(1-piperidinyl)—Ph


412
4-F
4-(1-pyrrolidinyl)—Ph


413
4-F
4-(2-imidazolyl)—Ph


414
4-F
4-(1-imidazolyl)—Ph


415
4-F
4-(2-thiazolyl)—Ph


416
4-F
4-(3-pyrazolyl)—Ph


417
4-F
4-(1-pyrazolyl)—Ph


418
4-F
4-(5-Me-1-tetrazolyl)—Ph


419
4-F
4-(1-Me-5-tetrazolyl)—Ph


420
4-F
4-(2-pyridyl)—Ph


421
4-F
4-(2-thienyl)—Ph


422
4-F
4-(2-furanyl)—Ph


423
4-F
2-CN—Ph


424
4-F
2-COMe—Ph


425
4-F
2-CO2Me—Ph


426
4-F
2-CONH2—Ph


427
4-F
2-CONHMe—Ph


428
4-F
2-F—Ph


429
4-F
2-Cl—Ph


430
4-F
2-Br—Ph


431
4-F
2-SO2NH2—Ph


432
4-F
2-SO2NHMe—Ph


433
4-F
2-CF3—Ph


434
4-F
2-OMe—Ph


435
4-F
2-SMe—Ph


436
4-F
2-SOMe—Ph


437
4-F
2-SO2Me—Ph


438
4-F
2-OH—Ph


439
4-F
2-CH2OH—Ph


440
4-F
2-CHOHMe—Ph


441
4-F
2-COH(Me)2—Ph


442
4-F
2-Me—Ph


443
4-F
2-Et—Ph


444
4-F
2-iPr—Ph


445
4-F
2-tBu—Ph


446
4-F
2-CH2CO2Me—Ph


447
4-F
2-(1-piperidinyl)—Ph


448
4-F
2-(1-pyrrolidinyl)—Ph


449
4-F
2-(2-imidazolyl)—Ph


450
4-F
2-(1-imidazolyl)—Ph


451
4-F
2-(2-thiazoly1)—Ph


452
4-F
2-(3-pyrazolyl)—Ph


453
4-F
2-(1-pyrazolyl)—Ph


454
4-F
2-(S-Me-1-tetrazolyl)—Ph


455
4-F
2-(1-Me-S-tetrazolyl)—Ph


456
4-F
2-(2-pyridyl)—Ph


457
4-F
2-(2-thienyl)—Ph


458
4-F
2-(2-furanyl)—Ph


459
4-F
2,4-diF—Ph


460
4-F
2,5-diF—Ph


461
4-F
2,6-diF—Ph


462
4-F
3,4-diF—Ph


463
4-F
3,5-diF—Ph


464
4-F
2,4-diCl—Ph


465
4-F
2,5-diCl—Ph


466
4-F
2,6-diCl—Ph


467
4-F
3,4-diCl—Ph


468
4-F
3,5-diCl—Ph


469
4-F
3,4-diCF3—Ph


470
4-F
3,5-diCF3—Ph


471
4-F
5-Cl-2-MeO—Ph


472
4-F
5-Cl-2-Me—Ph


473
4-F
2-F-S-Me—Ph


474
4-F
3-F-5-morpholino—Ph


475
4-F
3,4-OCH2O—Ph


476
4-F
3,4-OCH2CH2O—Ph


477
4-F
2-MeO-5-CONH2—Ph


478
4-F
2-MeO-4-(1-Me-5-tetrazolyl)—Ph


479
4-F
2-MeO-5-(1-Me-5-tetrazolyl)—Ph


480
4-F
3-CONH2-5-(1-Me-5-tetrazolyl)—Ph


481
4-F
1-naphthyl


482
4-F
2-naphthyl


483
4-F
2-thienyl


484
4-F
3-thienyl


485
4-F
2-furanyl


486
4-F
3-furanyl


487
4-F
2-pyridyl


488
4-F
3-pyridyl


489
4-F
4-pyridyl


490
4-F
2-indolyl


491
4-F
3-indolyl


492
4-F
5-indolyl


493
4-F
6-indolyl


494
4-F
3-indazolyl


495
4-F
5-indazolyl


496
4-F
6-indazolyl


497
4-F
2-imidazolyl


498
4-F
3-isoxazolyl


499
4-F
3-pyrazolyl


500
4-F
2-thiadiazolyl


501
4-F
2-thiazolyl


502
4-F
5-Ac-4-Me-2-thiazolyl


503
4-F
5-tetrazolyl


504
4-F
2-benzimidazolyl


505
4-F
5-benzimidazolyl


506
4-F
2-benzothiazolyl


507
4-F
5-benzothiazolyl


508
4-F
2-benzoxazolyl


509
4-F
5-benzoxazolyl


510
4-F
1-adamantyl


511
4-F
2-adamantyl


512
4-F
i-Pr


513
4-F
t-Bu


514
4-F
c-Hex


515
4-F
CH2CH2OMe


516
4-F
CH2CONH2


517
4-F
CH2CO2Me


518
4-F
CH(CH2Ph)CO2Me


519
4-F
CH2CH2NMe2


520
4-F
benzyl


521
4-F
phenethyl


522
4-F
2-(morpholin-1-yl)-Et


523
3-Cl
Ph


524
3-Cl
3-CN—Ph


525
3-Cl
3-COMe—Ph


526
3-Cl
3-CO2Me—Ph


527
3-Cl
3-CONH2—Ph


528
3-Cl
3-CONHMe—Ph


529
3-Cl
3-F—Ph


530
3-Cl
3-Cl—Ph


531
3-Cl
3-Br—Ph


532
3-Cl
3-SO2NH2—Ph


533
3-Cl
3-SO2NHMe—Ph


534
3-Cl
3-CF3—Ph


535
3-Cl
3-OMe—Ph


536
3-Cl
3-SMe—Ph


537
3-Cl
3-SOMe—Ph


538
3-Cl
3-SO2Me—Ph


539
3-Cl
3-OH—Ph


540
3-Cl
3-CH2OH—Ph


541
3-Cl
3-CHOHMe—Ph


542
3-Cl
3-COH(Me)2—Ph


543
3-Cl
3-Me—Ph


544
3-Cl
3-Et—Ph


545
3-Cl
3-iPr—Ph


546
3-Cl
3-tBu—Ph


547
3-Cl
3-CH2CO2Me—Ph


548
3-Cl
3-(1-piperidinyl)—Ph


549
3-Cl
3-(1-pyrrolidinyl)—Ph


550
3-Cl
3-(2-imidazolyl)—Ph


551
3-Cl
3-(1-imidazolyl)—Ph


552
3-Cl
3-(2-thiazolyl)—Ph


553
3-Cl
3-(3-pyrazolyl)—Ph


554
3-Cl
3-(1-pyrazolyl)—Ph


555
3-Cl
3-(5-Me-l-tetrazolyl)—Ph


556
3-Cl
3-(1-Me-5-tetrazolyl)—Ph


557
3-Cl
3-(2-pyridyl)—Ph


558
3-Cl
3-(2-thienyl)—Ph


559
3-Cl
3-(2-furanyl)—Ph


560
3-Cl
4-CN—Ph


561
3-Cl
4-COMe—Ph


562
3-Cl
4-CO2Me—Ph


563
3-Cl
4-CONH2—Ph


564
3-Cl
4-CONHMe—Ph


565
3-Cl
4-CONHPh—Ph


566
3-Cl
4-F—Ph


567
3-Cl
4-Cl—Ph


568
3-Cl
4-Br—Ph


569
3-Cl
4-SO2NH2—Ph


570
3-Cl
4-SO2NHMe—Ph


571
3-Cl
4-CF3—Ph


572
3-Cl
4-OMe—Ph


573
3-Cl
4-SMe—Ph


574
3-Cl
4-SOMe—Ph


575
3-Cl
4-SO2Me—Ph


576
3-Cl
4-OH—Ph


577
3-Cl
4-CH2OH—Ph


578
3-Cl
4-CHOHMe—Ph


579
3-Cl
4-COH(Me)2—Ph


580
3-Cl
4-Me—Ph


581
3-Cl
4-Et—Ph


582
3-Cl
4-iPr—Ph


583
3-Cl
4-tBu—Ph


584
3-Cl
4-CH2CO2Me—Ph


585
3-Cl
4-(1-piperidinyl)—Ph


586
3-Cl
4-(1-pyrrolidinyl)—Ph


587
3-Cl
4-(2-imidazolyl)—Ph


588
3-Cl
4-(1-imidazolyl)—Ph


589
3-Cl
4-(2-thiazolyl)—Ph


590
3-Cl
4-(3-pyrazolyl)—Ph


591
3-Cl
4-(1-pyrazolyl)—Ph


592
3-Cl
4-(5-Me-l-tetrazolyl)—Ph


593
3-Cl
4-(1-Me-5-tetrazolyl)—Ph


594
3-Cl
4-(2-pyridyl)—Ph


595
3-Cl
4-(2-thienyl)—Ph


596
3-Cl
4-(2-furanyl)—Ph


597
3-Cl
2-CN—Ph


598
3-Cl
2-COMe—Ph


599
3-Cl
2-CO2Me—Ph


600
3-Cl
2-CONH2—Ph


601
3-Cl
2-CONHMe—Ph


602
3-Cl
2-F—Ph


603
3-Cl
2-Cl—Ph


604
3-Cl
2-Br—Ph


605
3-Cl
2-SO2NH2—Ph


606
3-Cl
2-SO2NHMe—Ph


607
3-Cl
2-CF3—Ph


608
3-Cl
2-OMe—Ph


609
3-Cl
2-SMe—Ph


610
3-Cl
2-SOMe—Ph


611
3-Cl
2-SO2Me—Ph


612
3-Cl
2-OH—Ph


613
3-Cl
2-CH2OH—Ph


614
3-Cl
2-CHOHMe—Ph


615
3-Cl
2-COH(Me)2—Ph


616
3-Cl
2-Me—Ph


617
3-Cl
2-Et—Ph


618
3-Cl
2-iPr—Ph


619
3-Cl
2-tBu—Ph


620
3-Cl
2-CH2CO2Me—Ph


621
3-Cl
2-(1-piperidinyl)—Ph


622
3-Cl
2-(1-pyrrolidinyl)—Ph


623
3-Cl
2-(2-imidazolyl)—Ph


624
3-Cl
2-(1-imidazolyl)—Ph


625
3-Cl
2-(2-thiazolyl)—Ph


626
3-Cl
2-(3-pyrazolyl)—Ph


627
3-Cl
2-(1-pyrazolyl)—Ph


628
3-Cl
2-(5-Me-1-tetrazolyl)—Ph


629
3-Cl
2-(1-Me-5-tetrazolyl)—Ph


630
3-Cl
2-(2-pyridyl)—Ph


631
3-Cl
2-(2-thienyl)—Ph


632
3-Cl
2-(2-pyridyl)—Ph


633
3-Cl
2,4-diF—Ph


634
3-Cl
2,5-diF—Ph


635
3-Cl
2,6-diF—Ph


636
3-Cl
3,4-diE—Ph


637
3-Cl
3,5-diF—Ph


638
3-Cl
2,4-diCl—Ph


639
3-Cl
2,5-diCl—Ph


640
3-Cl
2,6-diCl—Ph


641
3-Cl
3,4-diCl—Ph


642
3-Cl
3,5-diCl—Ph


643
3-Cl
3,4-diCF3—Ph


644
3-Cl
3,5-diCF3—Ph


645
3-Cl
5-Cl-2-MeO—Ph


646
3-Cl
5-Cl-2-Me—Ph


647
3-Cl
2-F-5-Me—Ph


648
3-Cl
3-F-S-morpholino—Ph


649
3-Cl
3,4-OCH2O—Ph


650
3-Cl
3,4-OCH2CH2O—Ph


651
3-Cl
2-MeO-5-CONH2—Ph


652
3-Cl
2-MeO-4-(1-Me-5-tetrazolyl)—Ph


653
3-Cl
2-MeO-5-(1-Me-5-tetrazolyl)—Ph


654
3-Cl
3-CONH2-5-(1-Me-5-tetrazolyl)—Ph


655
3-Cl
1-naphthyl


656
3-Cl
2-naphthyl


657
3-Cl
2-thienyl


658
3-Cl
3-thienyl


659
3-Cl
2-furanyl


660
3-Cl
3-furanyl


661
3-Cl
2-pyridyl


662
3-Cl
3-pyridyl


663
3-Cl
4-pyridyl


664
3-Cl
2-indolyl


665
3-Cl
3-indolyl


666
3-Cl
5-indolyl


667
3-Cl
6-indolyl


668
3-Cl
3-indazolyl


669
3-Cl
5-indazolyl


670
3-Cl
6-indazolyl


671
3-Cl
2-imidazolyl


672
3-Cl
3-isoxazoyl


673
3-Cl
3-pyrazolyl


674
3-Cl
2-thiadiazolyl


675
3-Cl
2-thiazolyl


676
3-Cl
5-Ac-4-Me-2-thiazolyl


677
3-Cl
5-tetrazolyl


678
3-Cl
2-benzimidazolyl


679
3-Cl
5-benzimidazolyl


680
3-Cl
2-benzothiazolyl


681
3-Cl
5-benzothiazolyl


682
3-Cl
2-benzoxazolyl


683
3-Cl
5-benzoxazolyl


684
3-Cl
1-adamantyl


685
3-Cl
2-adamantyl


686
3-Cl
i-Pr


687
3-Cl
t-Bu


688
3-Cl
c-Hex


689
3-Cl
CH2CH2OMe


690
3-Cl
CH2CONH2


691
3-Cl
CH2CO2Me


692
3-Cl
CH(CH2Ph)CO2Me


696
3-Cl
2-(morpholin-1-yl)-Et


697
4-Cl
Ph


698
4-Cl
3-CN—Ph


699
4-Cl
3-COMe—Ph


700
4-Cl
3-CO2Me—Ph


701
4-Cl
3-CONH2—Ph


702
4-Cl
3-CONHMe—Ph


703
4-Cl
3-F—Ph


704
4-Cl
3-Cl—Ph


705
4-Cl
3-Br—Ph


706
4-Cl
3-SO2NH2—Ph


707
4-Cl
3-SO2NHMe—Ph


708
4-Cl
3-CF3—Ph


709
4-Cl
3-OMe—Ph


710
4-Cl
3-SMe—Ph


711
4-Cl
3-SOMe—Ph


712
4-Cl
3-SO2Me—Ph


713
4-Cl
3-OH—Ph


714
4-Cl
3-CH2OH—Ph


715
4-Cl
3-CHOHI4e—Ph


716
4-Cl
3-COH(Me)2—Ph


717
4-Cl
3-Me—Ph


718
4-Cl
3-Et—Ph


719
4-Cl
3-iPr—Ph


720
4-Cl
3-tBu—Ph


721
4-Cl
3-CH2CO2Me—Ph


722
4-Cl
3-(1-piperidinyl)—Ph


723
4-Cl
3-(1-pyrrolidinyl)—Ph


724
4-Cl
3-(2-imidazolyl)—Ph


725
4-Cl
3-(1-imidazolyl)—Ph


726
4-Cl
3-(2-thiazolyl)—Ph


727
4-Cl
3-(3-pyrazolyl)—Ph


728
4-Cl
3-(1-pyrazolyl)—Ph


729
4-Cl
3-(5-Me-1-tetrazolyl)—Ph


730
4-Cl
3-(1-Me-5-tetrazolyl)—Ph


731
4-Cl
3-(2-pyridyl)—Ph


732
4-Cl
3-(2-thienyl)—Ph


733
4-Cl
3-(2-furanyl)—Ph


734
4-Cl
4-CN—Ph


735
4-Cl
4-COMe—Ph


736
4-Cl
4-CO2Me—Ph


737
4-Cl
4-CONH2—Ph


738
4-Cl
4-CONHMe—Ph


739
4-Cl
4-CONHPh—Ph


740
4-Cl
4-F—Ph


741
4-Cl
4-Cl—Ph


742
4-Cl
4-Br—Ph


743
4-Cl
4-SO2NH2—Ph


744
4-Cl
4-SO2NHMe—Ph


745
4-Cl
4-CF3—Ph


746
4-Cl
4-OMe—Ph


747
4-Cl
4-SMe—Ph


748
4-Cl
4-SOMe—Ph


749
4-Cl
4-SO2Me—Ph


750
4-Cl
4-OH—Ph


751
4-Cl
4-CH2OH—Ph


752
4-Cl
4-CHOHMe—Ph


753
4-Cl
4-COH(Me)2—Ph


754
4-Cl
4-Me—Ph


755
4-Cl
4-Et—Ph


756
4-Cl
4-iPr—Ph


757
4-Cl
4-tBu—Ph


758
4-Cl
4-CH2CO2Me—Ph


759
4-Cl
4-(1-piperidinyl)—Ph


760
4-Cl
4-(1-pyrrolidinyl)—Ph


761
4-Cl
4-(2-imidazolyl)—Ph


762
4-Cl
4-(1-imidazolyl)—Ph


763
4-Cl
4-(2-thiazoly1)—Ph


764
4-Cl
4-(3-pyrazolyl)—Ph


765
4-Cl
4-(1-pyrazolyl)—Ph


766
4-Cl
4-(5-Me-1-tetrazolyl)—Ph


767
4-Cl
4-(1-Me-5-tetrazolyl)—Ph


768
4-Cl
4-(2-pyridyl)—Ph


769
4-Cl
4-(2-thienyl)—Ph


770
4-Cl
4-(2-furanyl)—Ph


771
4-Cl
2-CN—Ph


772
4-Cl
2-COMe—Ph


773
4-Cl
2-CO2Me—Ph


774
4-Cl
2-CONH2—Ph


775
4-Cl
2-CONHMe—Ph


776
4-Cl
2-F—Ph


777
4-Cl
2-Cl—Ph


778
4-Cl
2-Br—Ph


779
4-Cl
2-SO2NH2—Ph


780
4-Cl
2-SO2NHMe—Ph


781
4-Cl
2-CF3—Ph


782
4-Cl
2-OMe—Ph


783
4-Cl
2-SMe—Ph


784
4-Cl
2-SOMe—Ph


785
4-Cl
2-SO2Me—Ph


786
4-Cl
2-OH—Ph


787
4-Cl
2-CH2OH—Ph


788
4-Cl
2-CHOHMe—Ph


789
4-Cl
2-COH(Me)2—Ph


790
4-Cl
2-Me—Ph


791
4-Cl
2-Et—Ph


792
4-Cl
2-iPr—Ph


793
4-Cl
2-tBu—Ph


794
4-Cl
2-CH2CO2Me—Ph


795
4-Cl
2-(1-piperidinyl)—Ph


796
4-Cl
2-(1-pyrrolidinyl)—Ph


797
4-Cl
2-(2-imidazolyl)—Ph


798
4-Cl
2-(1-imidazolyl)—Ph


799
4-Cl
2-(2-thiazolyl)—Ph


800
4-Cl
2-(3-pyrazolyl)—Ph


801
4-Cl
2-(1-pyrazolyl)—Ph


802
4-Cl
2-(5-Me-1-tetrazolyl)—Ph


803
4-Cl
2-(1-Me-5-tetrazolyl)—Ph


804
4-Cl
2-(2-pyridyl)—Ph


805
4-Cl
2-(2-thienyl)—Ph


806
4-Cl
2-(2-furanyl)—Ph


807
4-Cl
2,4-diF—Ph


808
4-Cl
2,5-diF—Ph


809
4-Cl
2,6-diF—Ph


810
4-Cl
3,4-diF—Ph


811
4-Cl
3,5-diF—Ph


812
4-Cl
2,4-diCl—Ph


813
4-Cl
2,5-diCl—Ph


814
4-Cl
2,6-diCl—Ph


815
4-Cl
3,4-diCl—Ph


816
4-Cl
3,5-diCl—Ph


817
4-Cl
3,4-diCF3—Ph


818
4-Cl
3,5-diCF3—Ph


819
4-Cl
5-Cl-2-MeO—Ph


820
4-Cl
5-Cl-2-Me—Ph


821
4-Cl
2-F-5-Me—Ph


822
4-Cl
3-F-5-morpholino—Ph


823
4-Cl
3,4-OCH2O—Ph


824
4-Cl
3,4-OCH2CH2O—Ph


825
4-Cl
2-MeO-5-CONH2—Ph


826
4-Cl
2-MeO-4-(1-Me-5-tetrazolyl)—Ph


827
4-Cl
2-MeO-5-(1-Me-5-tetrazolyl)—Ph


828
4-Cl
3-CONH2-5-(1-Me-5-tetrazolyl)—Ph


829
4-Cl
1-naphthyl


830
4-Cl
2-naphthyl


831
4-Cl
2-thienyl


832
4-Cl
3-thienyl


833
4-Cl
2-furanyl


834
4-Cl
3-furanyl


835
4-Cl
2-pyridyl


836
4-Cl
3-pyridyl


837
4-Cl
4-pyridyl


838
4-Cl
2-indolyl


839
4-Cl
3-indolyl


840
4-Cl
5-indolyl


841
4-Cl
6-indolyl


842
4-Cl
3-indazolyl


843
4-Cl
5-indazolyl


844
4-Cl
6-indazolyl


845
4-Cl
2-imidazolyl


850
4-Cl
5-Ac-4-Me-2-thiazolyl


851
4-Cl
5-tetrazolyl


852
4-Cl
2-benzimidazolyl


853
4-Cl
5-benzimidazolyl


854
4-Cl
2-benzothiazolyl


855
4-Cl
5-benzothiazolyl


856
4-Cl
2-benzoxazolyl


857
4-Cl
5-benzoxazolyl


858
4-Cl
1-adamantyl


859
4-Cl
2-adamantyl


860
4-Cl
i-Pr


861
4-Cl
t-Bu


862
4-Cl
c-Hex


863
4-Cl
CH2CH2OMe


864
4-Cl
CH2CONH2


865
4-Cl
CH2CO2Me


866
4-Cl
CH(CH2Ph)CO2Me


867
4-Cl
CH2CH2NMe2


868
4-Cl
benzyl


869
4-Cl
phenethyl


870
4-Cl
2-(morpholin-1-yl)-Et
















TABLE 4














47 









48









49









50









51









52









53









54









55









56









57









58









59









60









61









62









63









64









65









66










Entry
R16
R9d
R3





            1
2-F
H
Ph


2
2-F
H
3-CN—Ph


3
2-F
H
3-COMe—Ph


4
2-F
H
3-CO2Me—Ph


5
2-F
H
3-CONH2—Ph


6
2-F
H
3-CONHMe—Ph


7
2-F
H
3-F—Ph


8
2-F
H
3-Cl—Ph


9
2-F
H
3-Br—Ph


10
2-F
H
3-SO2NH2—Ph


11
2-F
H
3-SO2NHMe—Ph


12
2-F
H
3-CF3—Ph


13
2-F
H
3-OMe—Ph


14
2-F
H
3-SMe—Ph


15
2-F
H
3-SOMe—Ph


16
2-F
H
3-SO2Me—Ph


17
2-F
H
3-OH—Ph


18
2-F
H
3-CH2OH—Ph


19
2-F
H
3-CHOHMe—Ph


20
2-F
H
3-COH(Me)2—Ph


21
2-F
H
3-Me—Ph


22
2-F
H
3-Et—Ph


23
2-F
H
3-iPr—Ph


24
2-F
H
3-tBu—Ph


25
2-F
H
3-CH2CO2Me—Ph


26
2-F
H
3-(1-piperidinyl)—Ph


27
2-F
H
3-(1-pyrrolidinyl)—Ph


28
2-F
H
3-(2-imidazolyl)—Ph


29
2-F
H
3-(1-imidazolyl)—Ph


30
2-F
H
3-(2-thiazolyl)—Ph


31
2-F
H
3-(3-pyrazolyl)—Ph


32
2-F
H
3-(1-pyrazolyl)—Ph


33
2-F
H
3-(5-Me-1-tetrazolyl)—Ph


34
2-F
H
3-(1-Me-5-tetrazolyl)—Ph


35
2-F
H
3-(2-pyridyl)—Ph


36
2-F
H
3-(2-thienyl)—Ph


37
2-F
H
3-(2-furanyl)—Ph


38
2-F
H
4-CN—Ph


39
2-F
H
4-COMe—Ph


40
2-F
H
4-CO2Me—Ph


41
2-F
H
4-CONH2—Ph


42
2-F
H
4-CONHMe—Ph


43
2-F
H
4-CONHPh—Ph


44
2-F
H
4-F—Ph


45
2-F
H
4-Cl—Ph


46
2-F
H
4-Br—Ph


47
2-F
H
4-SO2NH2—Ph


48
2-F
H
4-SO2NHMe—Ph


49
2-F
H
4-CF3—Ph


50
2-F
H
4-OMe—Ph


51
2-F
H
4-SMe—Ph


52
2-F
H
4-SOMe—Ph


53
2-F
H
4-SO2Me—Ph


54
2-F
H
4-OH—Ph


55
2-F
H
4-CH2OH—Ph


56
2-F
H
4-CHOHMe—Ph


57
2-F
H
4-COH(Me)2—Ph


58
2-F
H
4-Me—Ph


59
2-F
H
4-Et—Ph


60
2-F
H
4-iPr—Ph


61
2-F
H
4-tBu—Ph


62
2-F
H
4-CH2CO2Me—Ph


63
2-F
H
4-(1-piperidinyl)—Ph


64
2-F
H
4-(1-pyrrolidinyl)—Ph


65
2-F
H
4-(2-imidazolyl)—Ph


66
2-F
H
4-(1-imidazolyl)—Ph


67
2-F
H
4-(2-thiazolyl)—Ph


68
2-F
H
4-(3-pyrazol)—Ph


69
2-F
H
4-(1-pyrazolyl)—Ph


70
2-F
H
4-(5-Me-1-tetrazolyl)—Ph


71
2-F
H
4-(1-Me-5-tetrazolyl)—Ph


72
2-F
H
4-(2-pyridyl)—Ph


73
2-F
H
4-(2-thienyl)—Ph


74
2-F
H
4-(2-furanyl)—Ph


75
2-F
H
2-CN—Ph


76
2-F
H
2-COMe—Ph


77
2-F
H
2-CO2Me—Ph


78
2-F
H
2-CONH2—Ph


79
2-F
H
2-CONHMe—Ph


80
2-F
H
2-F—Ph


81
2-F
H
2-Cl—Ph


82
2-F
H
2-Br—Ph


83
2-F
H
2-SO2NH2—Ph


84
2-F
H
2-SO2NHMe—Ph


85
2-F
H
2-CF3—Ph


86
2-F
H
2-OMe—Ph


87
2-F
H
2-SMe—Ph


88
2-F
H
2-SOMe—Ph


89
2-F
H
2-SO2Me—Ph


90
2-F
H
2-OH—Ph


91
2-F
H
2-CH2OH—Ph


92
2-F
H
2-CHOHMe—Ph


93
2-F
H
2-COH(Me)2—Ph


94
2-F
H
2-Me—Ph


95
2-F
H
2-Et—Ph


96
2-F
H
2-iPr—Ph


97
2-F
H
2-tBu—Ph


98
2-F
H
2-CH2CO2Me—Ph


99
2-F
H
2-(1-piperidinyl)—Ph


100
2-F
H
2-(1-pyrrolidinyl)—Ph


101
2-F
H
2-(2-imidazolyl)—Ph


102
2-F
H
2-(1-imidazolyl)—Ph


103
2-F
H
2-(2-thiazolyl)—Ph


104
2-F
H
2-(3-pyrazolyl)—Ph


105
2-F
H
2-(1-pyrazolyl)—Ph


106
2-F
H
2-(5-Me-1-tetrazolyl)—Ph


107
2-F
H
2-(1-Me-5-tetrazolyl)—Ph


108
2-F
H
2-(2-pyridyl)—Ph


109
2-F
H
2-(2-thienyl)—Ph


110
2-F
H
2-(2-furanyl)—Ph


111
2-F
H
2,4-diF—Ph


112
2-F
H
2,5-diF—Ph


113
2-F
H
2,6-diF—Ph


114
2-F
H
3,4-diF—Ph


115
2-F
H
3,5-diF—Ph


116
2-F
H
2,4-diCl—Ph


117
2-F
H
2,5-diCl—Ph


118
2-F
H
2,6-diCl—Ph


119
2-F
H
3,4-diCl—Ph


120
2-F
H
3,5-diCl—Ph


121
2-F
H
3,4-diCF3—Ph


122
2-F
H
3, 5-diCF3—Ph


123
2-F
H
5-Cl-2-MeO—Ph


124
2-F
H
5-Cl-2-Me—Ph


125
2-F
H
2-F-5-Me—Ph


126
2-F
H
3-F-5-morpholino—Ph


127
2-F
H
3,4-OCH2O—Ph


128
2-F
H
3,4-OCH2CH2O—Ph


129
2-F
H
2-MeO-5-CONH2—Ph


130
2-F
H
2-MeO-4-(1-Me-5-tetrazolyl)—Ph


131
2-F
H
2-MeO-5-(1-Me-5-tetrazolyl)—Ph


132
2-F
H
3-CONH2-5-(1-Me-5-tetrazolyl)—Ph


133
2-F
H
1-naphthyl


134
2-F
H
2-naphthyl


135
2-F
H
2-thienyl


136
2-F
H
3-thienyl


137
2-F
H
2-furanyl


138
2-F
H
3-furanyl


139
2-F
H
2-pyridyl


140
2-F
H
3-pyridyl


141
2-F
H
4-pyridyl


142
2-F
H
2-indolyl


143
2-F
H
3-indolyl


144
2-F
H
5-indolyl


145
2-F
H
6-indolyl


146
2-F
H
3-indazolyl


147
2-F
H
5-indazolyl


148
2-F
H
6-indazolyl


149
2-F
H
2-imidazolyl


150
2-F
H
3-isoxazolyl


151
2-F
H
3-pyrazolyl


152
2-F
H
2-thiadiazolyl


153
2-F
H
2-thiazolyl


154
2-F
H
5-Ac-4-Me-2-thiazolyl


155
2-F
H
5-tetrazolyl


156
2-F
H
2-benzimidazolyl


157
2-F
H
5-benzimidazolyl


158
2-F
H
2-benzothiazolyl


159
2-F
H
5-benzothiazolyl


160
2-F
H
2-benzoxazolyl


161
2-F
H
5-benzoxazolyl


162
2-F
H
1-adarnantyl


163
2-F
H
2-adamantyl


164
2-F
H
i-Pr


165
2-F
H
t-Bu


166
2-F
H
c-Hex


167
2-F
H
CH2CH2OMe


168
2-F
H
CH2CONH2


169
2-F
H
CH2CO2Me


170
2-F
H
CH(CH2Ph)CO2Me


171
2-F
H
CH2CH2NMe2


172
2-F
H
benzyl


173
2-F
H
phenethyl


174
2-F
H
2-(morpholin-1-yl)-Et


175
3-F
H
Ph


176
3-F
H
3-CN—Ph


177
3-F
H
3-COMe—Ph


178
3-F
H
3-CO2Me—Ph


179
3-F
H
3-CONH2—Ph


180
3-F
H
3-CONHMe—Ph


181
3-F
H
3-F—Ph


182
3-F
H
3-Cl—Ph


183
3-F
H
3-Br—Ph


184
3-F
H
3-SO2NH2—Ph


185
3-F
H
3-SO2NHMe—Ph


186
3-F
H
3-CF3—Ph


187
3-F
H
3-OMe—Ph


188
3-F
H
3-SMe—Ph


189
3-F
H
3-SOMe—Ph


190
3-F
H
3-SO2Me—Ph


191
3-F
H
3-OH—Ph


192
3-F
H
3-CH2OH—Ph


193
3-F
H
3-CHOHMe—Ph


194
3-F
H
3-COH(Me)2—Ph


195
3-F
H
3-Me—Ph


196
3-F
H
3-Et—Ph


197
3-F
H
3-iPr—Ph


198
3-F
H
3-tBu—Ph


199
3-F
H
3-CH2CO2Me—Ph


200
3-F
H
3-(1-piperidinyl)—Ph


201
3-F
H
3-(1-pyrrolidinyl)—Ph


202
3-F
H
3-(2-imidazolyl)—Ph


203
3-F
H
3-(1-imidazolyl)—Ph


204
3-F
H
3-(2-thiazolyl)—Ph


205
3-F
H
3-(3-pyrazolyl)—Ph


206
3-F
H
3-(1-pyrazolyl)—Ph


207
3-F
H
3-(5-Me-1-tetrazolyl)—Ph


208
3-F
H
3-(1-Me-5-tetrazol 1)—Ph


209
3-F
H
3-(2-pyridyl)—Ph


210
3-F
H
3-(2-thienyl)—Ph


211
3-F
H
3-(2-furanyl)—Ph


212
3-F
H
4-CN—Ph


213
3-F
H
4-COMe—Ph


214
3-F
H
4-CO2Me—Ph


215
3-F
H
4-CONH2—Ph


216
3-F
H
4-CONHMe—Ph


217
3-F
H
4-CONHPh—Ph


218
3-F
H
4-F—Ph


219
3-F
H
4-Cl—Ph


220
3-F
H
4-Br—Ph


221
3-F
H
4-SO2NH2—Ph


222
3-F
H
4-SO2NHMe—Ph


223
3-F
H
4-CF3—Ph


224
3-F
H
4-OMe—Ph


225
3-F
H
4-SMe—Ph


226
3-F
H
4-SOMe—Ph


227
3-F
H
4-SO2Me—Ph


228
3-F
H
4-OH—Ph


229
3-F
H
4-CH2OH—Ph


230
3-F
H
4-CHOHMe—Ph


231
3-F
H
4-COH(Me)2—Ph


232
3-F
H
4-Me—Ph


233
3-F
H
4-Et—Ph


234
3-F
H
4-iPr—Ph


235
3-F
H
4-tBu—Ph


236
3-F
H
4-CH2CO2Me—Ph


237
3-F
H
4-(1-piperidinyl)—Ph


238
3-F
H
4-(1-pyrrolidinyl)—Ph


239
3-F
H
4-(2-imidazolyl)—Ph


240
3-F
H
4-(1-imidazolyl)—Ph


241
3-F
H
4-(2-thiazolyl)—Ph


242
3-F
H
4-(3-pyrazolyl)—Ph


243
3-F
H
4-(1-pyrazolyl)—Ph


244
3-F
H
4-(5-Me-1-tetrazolyl)—Ph


245
3-F
H
4-(1-Me-5-tetrazolyl)—Ph


246
3-F
H
4-(2-pyridyl)—Ph


247
3-F
H
4-(2-thienyl)—Ph


248
3-F
H
4-(2-furanyl)—Ph


249
3-F
H
2-CN—Ph


250
3-F
H
2-COMe—Ph


251
3-F
H
2-CO2Me—Ph


252
3-F
H
2-CONH2—Ph


253
3-F
H
2-CONHMe—Ph


254
3-F
H
2-F—Ph


255
3-F
H
2-Cl—Ph


256
3-F
H
2-Br—Ph


257
3-F
H
2-SO2NH2—Ph


258
3-F
H
2-SO2NHMe—Ph


259
3-F
H
2-CF3—Ph


260
3-F
H
2-OMe—Ph


261
3-F
H
2-SMe—Ph


262
3-F
H
2-SOMe—Ph


263
3-F
H
2-SO2Me—Ph


264
3-F
H
2-OH—Ph


265
3-F
H
2-CH2OH—Ph


266
3-F
H
2-CHOHMe—Ph


267
3-F
H
2-COH(Me)2—Ph


268
3-F
H
2-Me—Ph


269
3-F
H
2-Et—Ph


270
3-F
H
2-iPr—Ph


271
3-F
H
2-tBu—Ph


272
3-F
H
2-CH2CO2Me—Ph


273
3-F
H
2-(1-piperidinyl)—Ph


274
3-F
H
2-(1-pyrrolidinyl)—Ph


275
3-F
H
2-(2-imidazolyl)—Ph


276
3-F
H
2-(1-imidazolyl)—Ph


277
3-F
H
2-(2-thiazolyl)—Ph


278
3-F
H
2-(3-pyrazolyl)—Ph


279
3-F
H
2-(1-pyrazolyl)—Ph


280
3-F
H
2-(5-Me-1-tetrazolyl)—Ph


281
3-F
H
2- (1-Me-5-tetrazolyl) —Ph


282
3-F
H
2-(2-pyridyl)—Ph


283
3-F
H
2-(2-thienyl)—Ph


284
3-F
H
2-(2-furanyl)—Ph


285
3-F
H
2,4-diF—Ph


286
3-F
H
2,5-diF—Ph


287
3-F
H
2,6-diF—Ph


288
3-F
H
3,4-diF—Ph


289
3-F
H
3,5-diF—Ph


290
3-F
H
2,4-diCl—Ph


291
3-F
H
2,5-diCl—Ph


292
3-F
H
2,6-diCl—Ph


293
3-F
H
3,4-diCl—Ph


294
3-F
H
3,5-diCl—Ph


295
3-F
H
3,4-diCF3—Ph


296
3-F
H
3,5-diCF3—Ph


297
3-F
H
5-Cl-2-MeO—Ph


298
3-F
H
5-Cl-2-Me—Ph


299
3-F
H
2-F-5-Me—Ph


300
3-F
H
3-F-5-morpholino—Ph


301
3-F
H
3,4-OCH2O—Ph


302
3-F
H
3,4-OCH2CH2O—Ph


303
3-F
H
2-MeO-5-CONH2—Ph


304
3-F
H
2-MeO-4-(1-Me-5-tetrazolyl)—Ph


305
3-F
H
2-MeO-5-(1-Me-5-tetrazolyl)—Ph


306
3-F
H
3-CONH2-5-(1-Me-5-tetrazolyl)—Ph


307
3-F
H
1-naphthyl


308
3-F
H
2-naphthyl


309
3-F
H
2-thienyl


310
3-F
H
3-thienyl


311
3-F
H
2-furanyl


312
3-F
H
3-furanyl


313
3-F
H
2-pyridyl


314
3-F
H
3-pyridyl


315
3-F
H
4-pyridyl


316
3-F
H
2-indolyl


317
3-F
H
3-indolyl


318
3-F
H
5-indolyl


319
3-F
H
6-indolyl


320
3-F
H
3-indazolyl


321
3-F
H
5-indazolyl


322
3-F
H
6-indazolyl


323
3-F
H
2-imidazolyl


324
3-F
H
3-isoxazoyl


325
3-F
H
3-pyrazolyl


326
3-F
H
2-thiadiazolyl


327
3-F
H
2-thiazolyl


328
3-F
H
5-Ac-4-Me-2-thiazolyl


329
3-F
H
5-tetrazolyl


330
3-F
H
2-benzimidazolyl


331
3-F
H
5-benzimidazolyl


332
3-F
H
2-benzothiazolyl


333
3-F
H
5-benzothiazolyl


334
3-F
H
2-benzoxazolyl


335
3-F
H
5-benzoxazolyl


336
3-F
H
1-adamantyl


337
3-F
H
2-adamantyl


338
3-F
H
i-Pr


339
3-F
H
t-Bu


340
3-F
H
c-Hex


341
3-F
H
CH2CH2OMe


342
3-F
H
CH2CONH2


343
3-F
H
CH2CO2Me


344
3-F
H
CH(CH2Ph)CO2Me


345
3-F
H
CH2CH2NMe2


346
3-F
H
benzyl


347
3-F
H
phenethyl


348
3-F
H
2-(morpholin-1-yl)-Et


349
4-F
H
Ph


350
4-F
H
3-CN—Ph


351
4-F
H
3-COMe—Ph


352
4-F
H
3-CO2Me—Ph


353
4-F
H
3-CONH2—Ph


354
4-F
H
3-CONHMe—Ph


355
4-F
H
3-F—Ph


356
4-F
H
3-Cl—Ph


357
4-F
H
3-Br—Ph


358
4-F
H
3-SO2NH2—Ph


359
4-F
H
3-SO2NHMe—Ph


360
4-F
H
3-CF3—Ph


361
4-F
H
3-OMe—Ph


362
4-F
H
3-SMe—Ph


363
4-F
H
3-SOMe—Ph


364
4-F
H
3-SO2Me—Ph


365
4-F
H
3-OH—Ph


366
4-F
H
3-CH2OH—Ph


367
4-F
H
3-CHOHMe—Ph


368
4-F
H
3-COH(Me)2—Ph


369
4-F
H
3-Me—Ph


370
4-F
H
3-Et—Ph


371
4-F
H
3-iPr—Ph


372
4-F
H
3-tBu—Ph


373
4-F
H
3-CH2CO2Me—Ph


374
4-F
H
3-(1-piperidinyl)—Ph


375
4-F
H
3-(1-pyrrolidinyl)—Ph


376
4-F
H
3-(2-imidazolyl)—Ph


377
4-F
H
3-(1-irnidazolyl)—Ph


378
4-F
H
3-(2-thiazolyl)—Ph


379
4-F
H
3-(3-pyrazolyl)—Ph


380
4-F
H
3-(1-pyrazolyl)—Ph


381
4-F
H
3-(5-Me-1-tetrazolyl)—Ph


382
4-F
H
3-(l-Me-5-tetrazolyl)—Ph


383
4-F
H
3-(2-pyridyl)—Ph


384
4-F
H
3-(2-thienyl)—Ph


385
4-F
H
3-(2-furanyl)—Ph


386
4-F
H
4-CN—Ph


387
4-F
H
4-COMe—Ph


388
4-F
H
4-CO2Me—Ph


389
4-F
H
4-CONH2—Ph


390
4-F
H
4-CONHMe—Ph


391
4-F
H
4-CONHPh—Ph


392
4-F
H
4-F—Ph


393
4-F
H
4-Cl—Ph


394
4-F
H
4-Br—Ph


395
4-F
H
4-SO2NH2—Ph


396
4-F
H
4-SO2NHMe—Ph


397
4-F
H
4-CF3—Ph


398
4-F
H
4-OMe—Ph


399
4-F
H
4-SMe—Ph


400
4-F
H
4-SOMe—Ph


401
4-F
H
4-SO2Me—Ph


402
4-F
H
4-OH—Ph


403
4-F
H
4-CH2OH—Ph


404
4-F
H
4-CHOHMe—Ph


405
4-F
H
4-COH(Me)2—Ph


406
4-F
H
4-Me—Ph


407
4-F
H
4-Et—Ph


408
4-F
H
4-iPr—Ph


409
4-F
H
4-tBu—Ph


410
4-F
H
4-CH2CO2Me—Ph


411
4-F
H
4-(1-piperidinyl)—Ph


412
4-F
H
4-(1-pyrrolidinyl)—Ph


413
4-F
H
4-(2-imidazolyl)—Ph


414
4-F
H
4-(1-imidazolyl)—Ph


415
4-F
H
4-(2-thiazolyl)—Ph


416
4-F
H
4-(3-pyrazolyl)—Ph


417
4-F
H
4-(1-pyrazolyl)—Ph


418
4-F
H
4-(5-Me-1-tetrazolyl)—Ph


419
4-F
H
4-(1-Me-5-tetrazolyl)—Ph


420
4-F
H
4-(2-pyridyl)—Ph


421
4-F
H
4-(2-thieriyl)—Ph


422
4-F
H
4-(2-furanyl)—Ph


423
4-F
H
2-CN—Ph


424
4-F
H
2-COMe—Ph


425
4-F
H
2-CO2Me—Ph


426
4-F
H
2-CONH2—Ph


427
4-F
H
2-CONHMe—Ph


428
4-F
H
2-F—Ph


429
4-F
H
2-Cl—Ph


430
4-F
H
2-Br—Ph


431
4-F
H
2-SO2NH2—Ph


432
4-F
H
2-SO2NHMe—Ph


433
4-F
H
2-CF3—Ph


434
4-F
H
2-OMe—Ph


435
4-F
H
2-SMe—Ph


436
4-F
H
2-SOMe—Ph


437
4-F
H
2-SO2Me—Ph


438
4-F
H
2-OH—Ph


439
4-F
H
2-CH2OH—Ph


440
4-F
H
2-CHOHMe—Ph


441
4-F
H
2-COH(Me)2—Ph


442
4-F
H
2-Me—Ph


443
4-F
H
2-Et—Ph


444
4-F
H
2-iPr—Ph


445
4-F
H
2-tBu—Ph


446
4-F
H
2-CH2CO2Me—Ph


447
4-F
H
2-(1-piperidinyl)—Ph


448
4-F
H
2-(1-pyrrolidinyl)—Ph


449
4-F
H
2-(2-imidazolyl)—Ph


450
4-F
H
2-(1-imidazolyl)—Ph


451
4-F
H
2-(2-thiazolyl)—Ph


452
4-F
H
2-(3-pyrazolyl)—Ph


453
4-F
H
2-(1-pyrazolyl)—Ph


454
4-F
H
2-(5-Me-1-tetrazolyl)—Ph


455
4-F
H
2-(1-Me-5-tetrazolyl)—Ph


456
4-F
H
2-(2-pyridyl)—Ph


457
4-F
H
2-(2-thieriyl)—Ph


458
4-F
H
2-(2-furanyl)—Ph


459
4-F
H
2,4-diF—Ph


460
4-F
H
2,5-diF—Ph


461
4-F
H
2,6-diF—Ph


462
4-F
H
3,4-diF—Ph


463
4-F
H
3,5-diF—Ph


464
4-F
H
2,4-diCl—Ph


465
4-F
H
2,5-diCl—Ph


466
4-F
H
2,6-diCl—Ph


467
4-F
H
3,4-diCl—Ph


468
4-F
H
3,5-diCl—Ph


469
4-F
H
3,4-diCF3—Ph


470
4-F
H
3,5-diCF3—Ph


471
4-F
H
5-Cl-2-MeO—Ph


472
4-F
H
5-Cl-2-Me—Ph


473
4-F
H
2-F-5-Me—Ph


474
4-F
H
3-F-5-morpholino—Ph


475
4-F
H
3,4-OCH2O—Ph


476
4-F
H
3,4-OCH2CH2O—Ph


477
4-F
H
2-MeO-5-CONH2—Ph


478
4-F
H
2-MeO-4-(1-Me-5-tetrazolyl)—Ph


479
4-F
H
2-MeO-5-(1-Me-5-tetrazolyl)—Ph


480
4-F
H
3-CONH2-5-(1-Me-5-tetrazolyl)—Ph


481
4-F
H
1-naphthyl


482
4-F
H
2-naphthyl


483
4-F
H
2-thienyl


484
4-F
H
3-thienyl


485
4-F
H
2-furanyl


494
4-F
H
3-indazolyl


495
4-F
H
5-indazolyl


496
4-F
H
6-indazolyl


497
4-F
H
2-imidazolyl


498
4-F
H
3-isoxazoyl


499
4-F
H
3-pyrazolyl


500
4-F
H
2-thiadiazolyl


501
4-F
H
2-thiazolyl


502
4-F
H
5-Ac-4-Me-2-thiazolyl


503
4-F
H
5-tetrazolyl


504
4-F
H
2-benzimidazolyl


505
4-F
H
5-benzimidazolyl


506
4-F
H
2-benzothiazolyl


507
4-F
H
5-benzothiazolyl


508
4-F
H
2-benzoxazolyl


509
4-F
H
5-benzoxazolyl


510
4-F
H
1-adamantyl


511
4-F
H
2-adamantyl


512
4-F
H
i-Pr


513
4-F
H
t-Bu


514
4-F
H
c-Hex


515
4-F
H
CH2CH2OMe


516
4-F
H
CH2CONH2


517
4-F
H
CH2CO2Me


518
4-F
H
CH(CH2Ph)CO2Me


519
4-F
H
CH2CH2NMe2


520
4-F
H
benzyl


521
4-F
H
phenethyl


522
4-F
H
2-(morpholin-1-yl)-Et


523
3-Cl
H
Ph


524
3-Cl
H
3-CN—Ph


525
3-Cl
H
3-COMe—Ph


526
3-Cl
H
3-CO2Me—Ph


527
3-Cl
H
3-CONH2—Ph


528
3-Cl
H
3-CONHMe—Ph


529
3-Cl
H
3-F—Ph


530
3-Cl
H
3-Cl—Ph


531
3-Cl
H
3-Br—Ph


532
3-Cl
H
3-SO2NH2—Ph


533
3-Cl
H
3-SO2NHMe—Ph


534
3-Cl
H
3-CF3—Ph


535
3-Cl
H
3-OMe—Ph


536
3-Cl
H
3-SMe—Ph


537
3-Cl
H
3-SOMe—Ph


538
3-Cl
H
3-SO2Me—Ph


539
3-Cl
H
3-OH—Ph


540
3-Cl
H
3-CH2OH—Ph


541
3-Cl
H
3-CHOHNe—Ph


542
3-Cl
H
3-COH(Me)2—Ph


543
3-Cl
H
3-Me—Ph


544
3-Cl
H
3-Et—Ph


545
3-Cl
H
3-iPr—Ph


546
3-Cl
H
3-tBu—Ph


547
3-Cl
H
3-CH2CO2Me—Ph


548
3-Cl
H
3-(1-piperidinyl)—Ph


549
3-Cl
H
3-(1-pyrrolidinyl)—Ph


550
3-Cl
H
3-(2-imidazolyl)—Ph


551
3-Cl
H
3-(1-imidazolyl)—Ph


552
3-Cl
H
3-(2-thiazolyl)—Ph


553
3-Cl
H
3-(3-pyrazolyl)—Ph


554
3-Cl
H
3-(1-pyrazolyl)—Ph


555
3-Cl
H
3-(5-Me-1-tetrazolyl)—Ph


556
3-Cl
H
3-(1-Me-5-tetrazolyl)—Ph


557
3-Cl
H
3-(2-pyridyl)—Ph


558
3-Cl
H
3-(2-thienyl)—Ph


559
3-Cl
H
3-(2-furanyl)—Ph


560
3-Cl
H
4-CN—Ph


561
3-Cl
H
4-COMe—Ph


562
3-Cl
H
4-CO2Me—Ph


563
3-Cl
H
4-CONH2—Ph


564
3-Cl
H
4-CONHMe—Ph


565
3-Cl
H
4-CONHPh—Ph


566
3-Cl
H
4-F—Ph


567
3-Cl
H
4-Cl—Ph


568
3-Cl
H
4-Br—Ph


569
3-Cl
H
4-SO2NH2—Ph


570
3-Cl
H
4-SO2NHMe—Ph


571
3-Cl
H
4-CF3—Ph


572
3-Cl
H
4-OMe—Ph


573
3-Cl
H
4-SMe—Ph


574
3-Cl
H
4-SOMe—Ph


575
3-Cl
H
4-SO2Me—Ph


576
3-Cl
H
4-OH—Ph


577
3-Cl
H
4-CH2OH—Ph


578
3-Cl
H
4-CHOHMe—Ph


579
3-Cl
H
4-COH(Me)2—Ph


580
3-Cl
H
4-Me—Ph


581
3-Cl
H
4-Et—Ph


582
3-Cl
H
4-iPr—Ph


583
3-Cl
H
4-tBu—Ph


584
3-Cl
H
4-CH2CO2Me—Ph


585
3-Cl
H
4-(l-piperidinyl)—Ph


586
3-Cl
H
4-(1-pyrrolidinyl)—Ph


587
3-Cl
H
4-(2-imidazolyl)—Ph


588
3-Cl
H
4-(1-imidazolyl)—Ph


589
3-Cl
H
4-(2-thiazolyl)—Ph


590
3-Cl
H
4-(3-pyrazolyl)—Ph


591
3-Cl
H
4-(1-pyrazolyl)—Ph


592
3-Cl
H
4-(5-Me-1-tetrazolyl)—Ph


593
3-Cl
H
4-(1-Me-5-tetrazolyl)—Ph


594
3-Cl
H
4-(2-pyridyl)—Ph


595
3-Cl
H
4-(2-thienyl)—Ph


596
3-Cl
H
4-(2-furanyl)—Ph


597
3-Cl
H
2-CN—Ph


605
3-Cl
H
2-SO2NH2—Ph


606
3-Cl
H
2-SO2NHMe—Ph


607
3-Cl
H
2-CF3—Ph


608
3-Cl
H
2-OMe—Ph


609
3-Cl
H
2-SMe—Ph


610
3-Cl
H
2-SOMe—Ph


611
3-Cl
H
2-SO2Me—Ph


612
3-Cl
H
2-OH—Ph


613
3-Cl
H
2-CH2OH—Ph


614
3-Cl
H
2-CHOHNe—Ph


615
3-Cl
H
2-COH(Me)2—Ph


616
3-Cl
H
2-Me—Ph


617
3-Cl
H
2-Et—Ph


618
3-Cl
H
2-iPr—Ph


619
3-Cl
H
2-tBu—Ph


620
3-Cl
H
2-CH2CO2Me—Ph


621
3-Cl
H
2-(1-piperidinyl)—Ph


622
3-Cl
H
2-(l-pyrrolidinyl)—Ph


623
3-Cl
H
2-(2-imidazolyl)—Ph


624
3-Cl
H
2-(1-imidazolyl)—Ph


625
3-Cl
H
2-(2-thiazolyl)—Ph


626
3-Cl
H
2-(3-pyrazolyl)—Ph


627
3-Cl
H
2-(1-pyrazolyl)—Ph


628
3-Cl
H
2-(5-Me-1-tetrazolyl)—Ph


629
3-Cl
H
2-(1-Me-5-tetrazolyl)—Ph


630
3-Cl
H
2-(2-pyridyl)—Ph


631
3-Cl
H
2-(2-thienyl)—Ph


632
3-Cl
H
2-(2-furanyl)—Ph


633
3-Cl
H
2,4-diF—Ph


634
3-Cl
H
2,5-diF—Ph


635
3-Cl
H
2,6-diF—Ph


636
3-Cl
H
3,4-diF—Ph


637
3-Cl
H
3,5-diF—Ph


638
3-Cl
H
2,4-diCl—Ph


639
3-Cl
H
2,5-diCl—Ph


640
3-Cl
H
2,6-diCl—Ph


641
3-Cl
H
3,4-diCl—Ph


642
3-Cl
H
3,5-diCl—Ph


643
3-Cl
H
3,4-diCF3—Ph


644
3-Cl
H
3,5-diCF3—Ph


645
3-Cl
H
5-Cl-2-MeO—Ph


646
3-Cl
H
5-Cl-2-Me—Ph


647
3-Cl
H
2-F-S-Me—Ph


648
3-Cl
H
3-F-5-morpholino—Ph


649
3-Cl
H
3,4-OCH2O—Ph


650
3-Cl
H
3,4-OCH2CH2O—Ph


651
3-Cl
H
2-MeO-5-CONH2—Ph


652
3-Cl
H
2-MeO-4-(1-Me-5-tetrazolyl)—Ph


653
3-Cl
H
2-MeO-5-(1-Me-5-tetrazolyl)—Ph


654
3-Cl
H
3-CONH2-5-(1-Me-5-tetrazolyl)—Ph


655
3-Cl
H
1-naphthyl


656
3-Cl
H
2-naphthyl


657
3-Cl
H
2-thienyl


658
3-Cl
H
3-thienyl


659
3-Cl
H
2-furanyl


660
3-Cl
H
3-furanyl


661
3-Cl
H
2-pyridyl


662
3-Cl
H
3-pyridyl


663
3-Cl
H
4-pyridyl


664
3-Cl
H
2-indolyl


665
3-Cl
H
3-indolyl


666
3-Cl
H
5-indolyl


667
3-Cl
H
6-indolyl


668
3-Cl
H
3-indazolyl


669
3-Cl
H
5-indazolyl


670
3-Cl
H
6-indazolyl


671
3-Cl
H
2-imidazol 1


672
3-Cl
H
3-isoxazoyl


673
3-Cl
H
3-pyrazolyl


674
3-Cl
H
2-thiadiazolyl


675
3-Cl
H
2-thiazolyl


676
3-Cl
H
5-Ac-4-Me-2-thiazolyl


677
3-Cl
H
5-tetrazolyl


678
3-Cl
H
2-benzimidazolyl


679
3-Cl
H
5-benzimidazolyl


680
3-Cl
H
2-benzothiazolyl


681
3-Cl
H
5-benzothiazolyl


682
3-Cl
H
2-benzoxazolyl


683
3-Cl
H
5-benzoxazolyl


684
3-Cl
H
1-adamantyl


685
3-Cl
H
2-adamantyl


686
3-Cl
H
i-Pr


687
3-Cl
H
t-Bu


688
3-Cl
H
c-Hex


689
3-Cl
H
CH2CH2OMe


690
3-Cl
H
CH2CONH2


691
3-Cl
H
CH2CO2Me


692
3-Cl
H
CH(CH2Ph)CO2Me


693
3-Cl
H
CH2CH2NMe2


694
3-Cl
H
benzyl


695
3-Cl
H
phenethyl


696
3-Cl
H
2-(morpholin-1-yl)-Et


697
4-Cl
H
Ph


698
4-Cl
H
3-CN—Ph


699
4-Cl
H
3-COMe—Ph


700
4-Cl
H
3-CO2Me—Ph


701
4-Cl
H
3-CONH2—Ph


702
4-Cl
H
3-CONHMe—Ph


703
4-Cl
H
3-F—Ph


704
4-Cl
H
3-Cl—Ph


705
4-Cl
H
3-Br—Ph


706
4-Cl
H
3-SO2NH2—Ph


707
4-Cl
H
3-SO2NHMe—Ph


708
4-Cl
H
3-CF3—Ph


709
4-Cl
H
3-OMe—Ph


710
4-Cl
H
3-SMe—Ph


711
4-Cl
H
3-SOMe—Ph


712
4-Cl
H
3-SO2Me—Ph


713
4-Cl
H
3-OH—Ph


714
4-Cl
H
3-CH2OH—Ph


715
4-Cl
H
3-CHOHMe—Ph


716
4-Cl
H
3-COH(Me)2—Ph


717
4-Cl
H
3-Me—Ph


718
4-Cl
H
3-Et—Ph


719
4-Cl
H
3-iPr—Ph


720
4-Cl
H
3-tBu—Ph


721
4-Cl
H
3-CH2CO2Me—Ph


722
4-Cl
H
3-(1-piperidinyl)—Ph


723
4-Cl
H
3-(1-pyrrolidinyl)—Ph


724
4-Cl
H
3-(2-imidazolyl)—Ph


725
4-Cl
H
3-(1-imidazolyl)—Ph


726
4-Cl
H
3-(2-thiazolyl)—Ph


727
4-Cl
H
3-(3-pyrazolyl)—Ph


728
4-Cl
H
3-(1-pyrazolyl)—Ph


729
4-Cl
H
3-(5-Me-1-tetrazolyl)—Ph


730
4-Cl
H
3-(1-Me-5-tetrazolyl)—Ph


731
4-Cl
H
3-(2-pyridyl)—Ph


732
4-Cl
H
3-(2-thienyl)—Ph


733
4-Cl
H
3-(2-furariyl)—Ph


734
4-Cl
H
4-CN—Ph


735
4-Cl
H
4-COMe—Ph


736
4-Cl
H
4-CO2Me—Ph


737
4-Cl
H
4-CONH2—Ph


738
4-Cl
H
4-CONHMe—Ph


739
4-Cl
H
4-CONHPh—Ph


740
4-Cl
H
4-F—Ph


741
4-Cl
H
4-Cl—Ph


742
4-Cl
H
4-Br—Ph


743
4-Cl
H
4-SO2NH2—Ph


744
4-Cl
H
4-SO2NHMe—Ph


745
4-Cl
H
4-CF3—Ph


746
4-Cl
H
4-OMe—Ph


747
4-Cl
H
4-SMe—Ph


748
4-Cl
H
4-SOMe—Ph


749
4-Cl
H
4-SO2Me—Ph


750
4-Cl
H
4-OH—Ph


751
4-Cl
H
4-CH2OH—Ph


752
4-Cl
H
4-CHOHMe—Ph


753
4-Cl
H
4-COH(Me)2—Ph


754
4-Cl
H
4-Me—Ph


755
4-Cl
H
4-Et—Ph


756
4-Cl
H
4-iPr—Ph


757
4-Cl
H
4-tBu—Ph


758
4-Cl
H
4-CH2cC2Me—Ph


759
4-Cl
H
4-(1-piperidinyl)—Ph


760
4-Cl
H
4-(1-pyrrolidinyl)—Ph


761
4-Cl
H
4-(2-imidazolyl)—Ph


762
4-Cl
H
4-(1-imidazolyl)—Ph


763
4-Cl
H
4-(2-thiazolyl)—Ph


764
4-Cl
H
4-(3-pyrazolyl)—Ph


765
4-Cl
H
4-(1-pyrazolyl)—Ph


766
4-Cl
H
4-(5-Me-1-tetrazolyl)—Ph


767
4-Cl
H
4-(1-Me-5-tetrazolyl)—Ph


768
4-Cl
H
4-(2-pyridyl)—Ph


769
4-Cl
H
4-(2-thienyl)—Ph


770
4-Cl
H
4-(2-furanyl)—Ph


771
4-Cl
H
2-CN—Ph


772
4-Cl
H
2-COMe—Ph


773
4-Cl
H
2-CO2Me—Ph


774
4-Cl
H
2-CONH2—Ph


775
4-Cl
H
2-CONHMe—Ph


776
4-Cl
H
2-F—Ph


777
4-Cl
H
2-Cl—Ph


778
4-Cl
H
2-Br—Ph


779
4-Cl
H
2-SO2NH2—Ph


780
4-Cl
H
2-SO2NHMe—Ph


781
4-Cl
H
2-CF3—Ph


782
4-Cl
H
2-OMe—Ph


783
4-Cl
H
2-SMe—Ph


784
4-Cl
H
2-SOMe—Ph


785
4-Cl
H
2-SO2Me—Ph


786
4-Cl
H
2-OH—Ph


787
4-Cl
H
2-CH2OH—Ph


788
4-Cl
H
2-CHOHMe—Ph


789
4-Cl
H
2-COH(Me)2—Ph


790
4-Cl
H
2-Me—Ph


791
4-Cl
H
2-Et—Ph


792
4-Cl
H
2-iPr—Ph


793
4-Cl
H
2-tBu—Ph


794
4-Cl
H
2-CH2CO2Me—Ph


795
4-Cl
H
2-(1-piperidinyl)—Ph


796
4-Cl
H
2-(1-pyrrolidinyl)—Ph


797
4-Cl
H
2-(2-imidazolyl)—Ph


798
4-Cl
H
2-(1-imidazolyl)—Ph


799
4-Cl
H
2-(2-thiazolyl)—Ph


800
4-Cl
H
2-(3-pyrazolyl)—Ph


801
4-Cl
H
2-(1-pyrazolyl)—Ph


802
4-Cl
H
2-(5-Me-1-tetrazolyl)—Ph


803
4-Cl
H
2-(1-Me-5-tetrazolyl)—Ph


804
4-Cl
H
2-(2-pyridyl)—Ph


805
4-Cl
H
2-(2-thienyl)—Ph


806
4-Cl
H
2-(2-furanyl)—Ph


807
4-Cl
H
2,4-diF—Ph


808
4-Cl
H
2,5-diF—Ph


809
4-Cl
H
2,6-diF—Ph


810
4-Cl
H
3,4-diF—Ph


811
4-Cl
H
3,5-diF—Ph


812
4-Cl
H
2,4-diCl—Ph


813
4-Cl
H
2,5-diCl—Ph


814
4-Cl
H
2,6-diCl—Ph


815
4-Cl
H
3,4-diCl—Ph


816
4-Cl
H
3,5-diCl—Ph


817
4-Cl
H
3,4-diCF3—Ph


818
4-Cl
H
3,5-diCF3—Ph


819
4-Cl
H
5-Cl-2-MeO—Ph


820
4-Cl
H
5-Cl-2-Me—Ph


821
4-Cl
H
2-F-5-Me—Ph


822
4-Cl
H
3-F-5-morpholino—Ph


823
4-Cl
H
3,4-OCH2O—Ph


824
4-Cl
H
3,4-OCH2CH2O—Ph


825
4-Cl
H
2-MeO-5-CONH2—Ph


826
4-Cl
H
2-MeO-4-(1-Me-5-tetrazolyl)—Ph


827
4-Cl
H
2-MeO-5-(1-Me-5-tetrazolyl)—Ph


828
4-Cl
H
3-CONH2-5-(1-Me-5-tetrazolyl)—Ph


829
4-Cl
H
1-naphthyl


830
4-Cl
H
2-naphthyl


831
4-Cl
H
2-thienyl


832
4-Cl
H
3-thienyl


833
4-Cl
H
2-furanyl


834
4-Cl
H
3-furanyl


835
4-Cl
H
2-pyridyl


836
4-Cl
H
3-pyridyl


837
4-Cl
H
4-pyridyl


838
4-Cl
H
2-indolyl


839
4-Cl
H
3-indolyl


840
4-Cl
H
5-indolyl


841
4-Cl
H
6-iridolyl


842
4-Cl
H
3-indazolyl


843
4-Cl
H
5-indazolyl


844
4-Cl
H
6-indazolyl


845
4-Cl
H
2-imidazolyl


846
4-Cl
H
3-isoxazoyl


847
4-Cl
H
3-pyrazolyl


848
4-Cl
H
2-thiadiazolyl


849
4-Cl
H
2-thiazolyl


850
4-Cl
H
5-Ac-4-Me-2-thiazolyl


851
4-Cl
H
5-tetrazolyl


852
4-Cl
H
2-benzimidazolyl


853
4-Cl
H
5-benzimidazolyl


854
4-Cl
H
2-benzothiazolyl


855
4-Cl
H
5-benzothiazolyl


856
4-Cl
H
2-benzoxazolyl


857
4-Cl
H
5-benzoxazolyl


858
4-Cl
H
1-adamantyl


859
4-Cl
H
2-adamantyl


860
4-Cl
H
i-Pr


861
4-Cl
H
t-Bu


862
4-Cl
H
c-Hex


863
4-Cl
H
CH2CH2OMe


864
4-Cl
H
CH2CONH2


865
4-Cl
H
CH2CO2Me


866
4-Cl
H
CH(CH2Ph)CO2Me


867
4-Cl
H
CH2CH2NMe2


868
4-Cl
H
benzyl


869
4-Cl
H
phenethyl


870
4-Cl
H
2-(morpholin-1-yl)-Et


871
2-F
Me
Ph


872
2-F
Me
3-CN—Ph


880
2-F
Me
3-SO2NH2—Ph


881
2-F
Me
3-SO2NHMe—Ph


882
2-F
Me
3-CF3—Ph


883
2-F
Me
3-OMe—Ph


884
2-F
Me
3-SMe—Ph


885
2-F
Me
3-SOMe—Ph


886
2-F
Me
3-SO2Me—Ph


887
2-F
Me
3-OH—Ph


888
2-F
Me
3-CH2OH—Ph


889
2-F
Me
3-CHOHMe—Ph


890
2-F
Me
3-COH(Me)2—Ph


891
2-F
Me
3-Me—Ph


892
2-F
Me
3-Et—Ph


893
2-F
Me
3-iPr—Ph


894
2-F
Me
3-tBu—Ph


895
2-F
Me
3-CH2CO2Me—Ph


896
2-F
Me
3-(1-piperidinyl)—Ph


897
2-F
Me
3-(1-pyrrolidinyl)—Ph


898
2-F
Me
3-(2-imidazolyl)—Ph


899
2-F
Me
3-(1-imidazolyl)—Ph


900
2-F
Me
3-(2-thiazolyl)—Ph


901
2-F
Me
3-(3-pyrazolyl)—Ph


902
2-F
Me
3-(1-pyrazolyl)—Ph


903
2-F
Me
3-(5-Me-1-tetrazolyl)—Ph


904
2-F
Me
3-(1-Me-5-tetrazolyl)—Ph


905
2-F
Me
3-(2-pyridyl)—Ph


906
2-F
Me
3-(2-thienyl)—Ph


907
2-F
Me
3-(2-furanyl)—Ph


908
2-F
Me
4-CN—Ph


909
2-F
Me
4-COMe—Ph


910
2-F
Me
4-CO2Me—Ph


911
2-F
Me
4-CONH2—Ph


912
2-F
Me
4-CONHMe—Ph


913
2-F
Me
4-CONHPh—Ph


914
2-F
Me
4-F—Ph


915
2-F
Me
4-Cl—Ph


916
2-F
Me
4-Br—Ph


917
2-F
Me
4-SO2NH2—Ph


918
2-F
Me
4-SO2NHMe—Ph


919
2-F
Me
4-CF3—Ph


920
2-F
Me
4-OMe—Ph


921
2-F
Me
4-SMe—Ph


922
2-F
Me
4-SOMe—Ph


923
2-F
Me
4-SO2Me—Ph


924
2-F
Me
4-OH—Ph


925
2-F
Me
4-CH2OH—Ph


926
2-F
Me
4-CHOHMe—Ph


927
2-F
Me
4-COH(Me)2—Ph


928
2-F
Me
4-Me—Ph


929
2-F
Me
4-Et—Ph


930
2-F
Me
4-ipr—Ph


931
2-F
Me
4-tBu—Ph


932
2-F
Me
4-CH2CO2Me—Ph


933
2-F
Me
4-(1-piperidinyl)—Ph


934
2-F
Me
4-(1-pyrrolidinyl)—Ph


935
2-F
Me
4-(2-imidazolyl)—Ph


936
2-F
Me
4-(1-imidazolyl)—Ph


937
2-F
Me
4-(2-thiazolyl)—Ph


938
2-F
Me
4-(3-pyrazolyl)—Ph


939
2-F
Me
4-(1-pyrazolyl)—Ph


940
2-F
Me
4-(5-Me-1-tetrazolyl)—Ph


941
2-F
Me
4-(1-Me-5-tetrazolyl)—Ph


942
2-F
Me
4-(2-pyridyl)—Ph


943
2-F
Me
4-(2-thienyl)—Ph


944
2-F
Me
4-(2-furanyl)—Ph


945
2-F
Me
2-CN—Ph


946
2-F
Me
2-COMe—Ph


947
2-F
Me
2-CO2Me—Ph


948
2-F
Me
2-CONH2—Ph


949
2-F
Me
2-CONHMe—Ph


950
2-F
Me
2-F—Ph


951
2-F
Me
2-Cl—Ph


952
2-F
Me
2-Br—Ph


953
2-F
Me
2-SO2NH2—Ph


954
2-F
Me
2-SO2NHMe—Ph


955
2-F
Me
2-CF3—Ph


956
2-F
Me
2-OMe—Ph


957
2-F
Me
2-SMe—Ph


958
2-F
Me
2-SOMe—Ph


959
2-F
Me
2-SO2Me—Ph


960
2-F
Me
2-OH—Ph


961
2-F
Me
2-CH2OH—Ph


962
2-F
Me
2-CHOHMe—Ph


963
2-F
Me
2-COH(Me)2—Ph


964
2-F
Me
2-Me—Ph


965
2-F
Me
2-Et—Ph


966
2-F
Me
2-iPr—Ph


967
2-F
Me
2-tBu—Ph


968
2-F
Me
2-CH2CO2Me—Ph


969
2-F
Me
2-(1-piperidinyl)—Ph


970
2-F
Me
2-(1-pyrrolidinyl)—Ph


971
2-F
Me
2-(2-imidazolyl)—Ph


972
2-F
Me
2-(1-imidazolyl)—Ph


973
2-F
Me
2-(2-thiazolyl)—Ph


974
2-F
Me
2-(3-pyrazolyl)—Ph


975
2-F
Me
2-(1-pyrazolyl)—Ph


976
2-F
Me
2-(5-Me-1-tetrazolyl)—Ph


977
2-F
Me
2-(1-Me-5-tetrazolyl)—Ph


978
2-F
Me
2-(2-pyridyl)—Ph


979
2-F
Me
2-(2-thienyl)—Ph


980
2-F
Me
2-(2-furanyl)—Ph


981
2-F
Me
2,4-diF—Ph


982
2-F
Me
2,5-diF—Ph


983
2-F
Me
2,6-diF—Ph


984
2-F
Me
3,4-diF—Ph


985
2-F
Me
3,5-diF—Ph


986
2-F
Me
2,4-diCl—Ph


987
2-F
Me
2,5-diCl—Ph


988
2-F
Me
2,6-diCl—Ph


989
2-F
Me
3,4-diCl—Ph


990
2-F
Me
3,5-diCl—Ph


991
2-F
Me
3,4-diCF3—Ph


992
2-F
Me
3,5-diCF3—Ph


993
2-F
Me
5-Cl-2-MeO—Ph


994
2-F
Me
5-Cl-2-Me—Ph


995
2-F
Me
2-F-5-Me—Ph


996
2-F
Me
3-F-5-morpholino—Ph


997
2-F
Me
3,4-OCH2O—Ph


998
2-F
Me
3,4-OCH2CH2O—Ph


999
2-F
Me
2-MeO-5-CONH2—Ph


1000
2-F
Me
2-MeO-4-(1-Me-5-tetrazolyl)—Ph


1001
2-F
Me
2-MeO-5-(1-Me-5-tetrazolyl)—Ph


1002
2-F
Me
3-CONH2-5-(1-Me-5-tetrazolyl)—Ph


1003
2-F
Me
1-naphthyl


1004
2-F
Me
2-naphthyl


1005
2-F
Me
2-thienyl


1006
2-F
Me
3-thienyl


1007
2-F
Me
2-furanyl


1008
2-F
Me
3-furanyl


1009
2-F
Me
2-pyridyl


1010
2-F
Me
3-pyridyl


1011
2-F
Me
4-pyridyl


1012
2-F
Me
2-indolyl


1013
2-F
Me
3-indolyl


1014
2-F
Me
5-indolyl


1015
2-F
Me
6-indolyl


1016
2-F
Me
3-indazolyl


1017
2-F
Me
5-indazolyl


1018
2-F
Me
6-indazolyl


1019
2-F
Me
2-imidazolyl


1020
2-F
Me
3-isoxazoyl


1021
2-F
Me
3-pyrazolyl


1022
2-F
Me
2-thiadiazolyl


1023
2-F
Me
2-thiazolyl


1024
2-F
Me
5-Ac-4-Me-2-thiazolyl


1025
2-F
Me
5-tetrazolyl


1026
2-F
Me
2-benzimidazolyl


1027
2-F
Me
5-benzimidazolyl


1028
2-F
Me
2-benzothiazolyl


1029
2-F
Me
5-benzothiazolyl


1030
2-F
Me
2-benzoxazolyl


1031
2-F
Me
5-benzoxazolyl


1032
2-F
Me
1-adamantyl


1033
2-F
Me
2-adamantyl


1034
2-F
Me
i-Pr


1035
2-F
Me
t-Bu


1036
2-F
Me
c-Hex


1037
2-F
Me
CH2CH2OMe


1038
2-F
Me
CH2CONH2


1039
2-F
Me
CH2CO2Me


1040
2-F
Me
CH(CH2Ph)CO2Me


1041
2-F
Me
CH2CH2NMe2


1042
2-F
Me
benzyl


1043
2-F
Me
phenethyl


1044
2-F
Me
2-(morpholin-1-yl)-Et


1045
3-F
Me
Ph


1046
3-F
Me
3-CN—Ph


1047
3-F
Me
3-COMe—Ph


1048
3-F
Me
3-CO2Me—Ph


1049
3-F
Me
3-CONH2—Ph


1050
3-F
Me
3-CONHMe—Ph


1051
3-F
Me
3-F—Ph


1052
3-F
Me
3-Cl—Ph


1053
3-F
Me
3-Br—Ph


1054
3-F
Me
3-SO2NH2—Ph


1055
3-F
Me
3-SO2NHMe—Ph


1056
3-F
Me
3-CF3—Ph


1057
3-F
Me
3-OMe—Ph


1058
3-F
Me
3-SMe—Ph


1059
3-F
Me
3-SOMe—Ph


1060
3-F
Me
3-SO2Me—Ph


1061
3-F
Me
3-OH—Ph


1062
3-F
Me
3-CH2OH—Ph


1063
3-F
Me
3-CHOHMe—Ph


1064
3-F
Me
3-COH(Me)2—Ph


1065
3-F
Me
3-Me—Ph


1066
3-F
Me
3-Et—Ph


1067
3-F
Me
3-iPr—Ph


1068
3-F
Me
3-tBu—Ph


1069
3-F
Me
3-CH2CO2Me—Ph


1070
3-F
Me
3-(1-piperidinyl)—Ph


1071
3-F
Me
3-(1-pyrrolidinyl)—Ph


1072
3-F
Me
3-(2-imiClazolyl)—Ph


1073
3-F
Me
3-(1-imidazolyl)—Ph


1074
3-F
Me
3-(2-thiazolyl)—Ph


1075
3-F
Me
3-(3-pyrazolyl)—Ph


1076
3-F
Me
3-(1-pyrazolyl)—Ph


1077
3-F
Me
3-(5-Me-1-tetrazolyl)—Ph


1078
3-F
Me
3-(1-Me-5-tetrazolyl)—Ph


1079
3-F
Me
3-(2-pyridyl)—Ph


1080
3-F
Me
3-(2-thienyl)—Ph


1081
3-F
Me
3-(2-furanyl)—Ph


1082
3-F
Me
4-CN—Ph


1083
3-F
Me
4-COMe—Ph


1084
3-F
Me
4-CO2Me—Ph


1085
3-F
Me
4-CONH2—Ph


1086
3-F
Me
4-CONHMe—Ph


1087
3-F
Me
4-CONHPh—Ph


1088
3-F
Me
4-F—Ph


1089
3-F
Me
4-Cl—Ph


1090
3-F
Me
4-Br—Ph


1091
3-F
Me
4-SO2NH2—Ph


1092
3-F
Me
4-SO2NHMe—Ph


1093
3-F
Me
4-CF3—Ph


1094
3-F
Me
4-ONe—Ph


1095
3-F
Me
4-SMe—Ph


1096
3-F
Me
4-SOMe—Ph


1097
3-F
Me
4-SO2Me—Ph


1098
3-F
Me
4-OH—Ph


1099
3-F
Me
4-CH2OH—Ph


1100
3-F
Me
4-CHOHMe—Ph


1101
3-F
Me
4-COH(Me)2—Ph


1102
3-F
Me
4-Me—Ph


1103
3-F
Me
4-Et—Ph


1104
3-F
Me
4-iPr—Ph


1105
3-F
Me
4-tBu—Ph


1106
3-F
Me
4-CH2CO2Me—Ph


1107
3-F
Me
4-(1-piperidinyl)—Ph


1108
3-F
Me
4-(1-pyrrolidinyl)—Ph


1109
3-F
Me
4-(2-imidazolyl)—Ph


1110
3-F
Me
4-(1-imidazolyl)—Ph


1111
3-F
Me
4-(2-thiazolyl)—Ph


1112
3-F
Me
4-(3-pyrazolyl)—Ph


1113
3-F
Me
4-(1-pyrazolyl)—Ph


1114
3-F
Me
4-(5-Me-1-tetrazolyl)—Ph


1115
3-F
Me
4-(1-Me-5-tetrazolyl)—Ph


1116
3-F
Me
4-(2-pyridyl)—Ph


1117
3-F
Me
4-(2-thienyl)—Ph


1118
3-F
Me
4-(2-furanyl)—Ph


1119
3-F
Me
2-CN—Ph


1120
3-F
Me
2-COMe—Ph


1121
3-F
Me
2-CO2Me—Ph


1122
3-F
Me
2-CONH2—Ph


1123
3-F
Me
2-CONHMe—Ph


1124
3-F
Me
2-F—Ph


1125
3-F
Me
2-Cl—Ph


1126
3-F
Me
2-Br—Ph


1127
3-F
Me
2-SO2NH2—Ph


1128
3-F
Me
2-SO2NHMe—Ph


1129
3-F
Me
2-CF3—Ph


1130
3-F
Me
2-OMe—Ph


1131
3-F
Me
2-SMe—Ph


1132
3-F
Me
2-SOMe—Ph


1133
3-F
Me
2-SO2Me—Ph


1134
3-F
Me
2-OH—Ph


1135
3-F
Me
2-CH2OH—Ph


1136
3-F
Me
2-CHOHMe—Ph


1137
3-F
Me
2-COH(Me)2—Ph


1138
3-F
Me
2-Me—Ph


1139
3-F
Me
2-Et—Ph


1140
3-F
Me
2-iPr—Ph


1141
3-F
Me
2-tBu—Ph


1142
3-F
Me
2-CH2CO2Me—Ph


1143
3-F
Me
2-(1-piperidinyl)—Ph


1144
3-F
Me
2-(1-pyrrolidinyl)—Ph


1145
3-F
Me
2-(2-imidazolyl)—Ph


1146
3-F
Me
2-(1-imidazolyl)—Ph


1147
3-F
Me
2-(2-thiazolyl)—Ph


1148
3-F
Me
2-(3-pyrazolyl)—Ph


1149
3-F
Me
2-(1-pyrazolyl)—Ph


1150
3-F
Me
2-(5-Me-1-tetrazolyl)—Ph


1151
3-F
Me
2-(1-Me-5-tetrazolyl)—Ph


1152
3-F
Me
2-(2-pyridyl)—Ph


1153
3-F
Me
2-(2-thienyl)—Ph


1154
3-F
Me
2-(2-furanyl)—Ph


1155
3-F
Me
2,4-diF—Ph


1156
3-F
Me
2,5-diF—Ph


1157
3-F
Me
2,6-diF—Ph


1158
3-F
Me
3,4-diF—Ph


1159
3-F
Me
3,5-diF—Ph


1160
3-F
Me
2,4-diCl—Ph


1161
3-F
Me
2,5-diCl—Ph


1162
3-F
Me
2,6-diCl—Ph


1163
3-F
Me
3,4-diCl—Ph


1164
3-F
Me
3,5-diCl—Ph


1165
3-F
Me
3,4-diCF3—Ph


1166
3-F
Me
3,5-diCF3—Ph


1167
3-F
Me
5-Cl-2-MeO—Ph


1168
3-F
Me
5-Cl-2-Me—Ph


1169
3-F
Me
2-F-5-Me—Ph


1170
3-F
Me
3-F-5-morpholino—Ph


1171
3-F
Me
3,4-OCH2O—Ph


1172
3-F
Me
3,4-OCH2CH2O—Ph


1173
3-F
Me
2-MeO-5-CONH2—Ph


1174
3-F
Me
2-MeO-4-(1-Me-5-tetrazolyl)—Ph


1175
3-F
Me
2-MeO-5-(1-Me-5-tetrazolyl)—Ph


1176
3-F
Me
3-CONH2-5-(1-Me-5-tetrazolyl)—Ph


1177
3-F
Me
1-naphthyl


1178
3-F
Me
2-naphthyl


1179
3-F
Me
2-thienyl


1180
3-F
Me
3-thienyl


1181
3-F
Me
2-furanyl


1182
3-F
Me
3-furanyl


1183
3-F
Me
2-pyridyl


1184
3-F
Me
3-pyridyl


1185
3-F
Me
4-pyridyl


1186
3-F
Me
2-indolyl


1187
3-F
Me
3-indolyl


1188
3-F
Me
5-indolyl


1189
3-F
Me
6-indolyl


1190
3-F
Me
3-indazolyl


1191
3-F
Me
5-indazolyl


1192
3-F
Me
6-indazolyl


1193
3-F
Me
2-imidazolyl


1194
3-F
Me
3-isoxazoyl


1195
3-F
Me
3-pyrazolyl


1196
3-F
Me
2-thiadiazolyl


1197
3-F
Me
2-thiazolyl


1198
3-F
Me
5-Ac-4-Me-2-thiazolyl


1199
3-F
Me
5-tetrazolyl


1200
3-F
Me
2-benziinidazolyl


1201
3-F
Me
5-benzimidazolyl


1202
3-F
Me
2-benzothiazolyl


1203
3-F
Me
5-benzothiazolyl


1204
3-F
Me
2-benzoxazolyl


1205
3-F
Me
5-benzoxazolyl


1206
3-F
Me
1-adamantyl


1207
3-F
Me
2-adamantyl


1208
3-F
Me
i-Pr


1209
3-F
Me
t-Bu


1210
3-F
Me
c-Hex


1211
3-F
Me
CH2CH2OMe


1212
3-F
Me
CH2CONH2


1213
3-F
Me
CH2CO2Me


1214
3-F
Me
CH(CH2Ph)CO2Me


1215
3-F
Me
CH2CH2NMe2


1216
3-F
Me
benzyl


1217
3-F
Me
phenethyl


1218
3-F
Me
2-(morpholin-1-yl)-Et


1219
4-F
Me
Ph


1220
4-F
Me
3-CN—Ph


1221
4-F
Me
3-COMe—Ph


1222
4-F
Me
3-CO2Me—Ph


1223
4-F
Me
3-CONH2—Ph


1224
4-F
Me
3-CONHMe—Ph


1225
4-F
Me
3-F—Ph


1226
4-F
Me
3-Cl—Ph


1227
4-F
Me
3-Br—Ph


1228
4-F
Me
3-SO2NH2—Ph


1229
4-F
Me
3-SO2NHMe—Ph


1230
4-F
Me
3-CF3—Ph


1231
4-F
Me
3-OMe—Ph


1232
4-F
Me
3-SMe—Ph


1233
4-F
Me
3-SOMe—Ph


1234
4-F
Me
3-SO2Me—Ph


1235
4-F
Me
3-OH—Ph


1236
4-F
Me
3-CH2OH—Ph


1237
4-F
Me
3-CHOHMe—Ph


1238
4-F
Me
3-COH(Me)2—Ph


1239
4-F
Me
3-Me—Ph


1240
4-F
Me
3-Et—Ph


1241
4-F
Me
3-iPr—Ph


1242
4-F
Me
3-tBu—Ph


1243
4-F
Me
3-CH2CO2Me—Ph


1244
4-F
Me
3-(1-piperidinyl)—Ph


1245
4-F
Me
3-(1-pyrrolidinyl)—Ph


1246
4-F
Me
3-(2-imidazolyl)—Ph


1247
4-F
Me
3-(1-imidazolyl)—Ph


1248
4-F
Me
3-(2-thiazolyl)—Ph


1249
4-F
Me
3-(3-pyrazolyl)—Ph


1250
4-F
Me
3-(1-pyrazolyl)—Ph


1251
4-F
Me
3-(5-Me-1-tetrazolyl)—Ph


1252
4-F
Me
3-(1-Me-5-tetrazolyl)—Ph


1253
4-F
Me
3-(2-pyridyl)—Ph


1254
4-F
Me
3-(2-thienyl)—Ph


1255
4-F
Me
3-(2-furanyl)—Ph


1256
4-F
Me
4-CN—Ph


1257
4-F
Me
4-COMe—Ph


1258
4-F
Me
4-CO2Me—Ph


1259
4-F
Me
4-CONH2—Ph


1260
4-F
Me
4-CONHMe—Ph


1261
4-F
Me
4-CONHPh—Ph


1262
4-F
Me
4-F—Ph


1263
4-F
Me
4-Cl—Ph


1264
4-F
Me
4-Br—Ph


1265
4-F
Me
4-SO2NH2—Ph


1266
4-F
Me
4-SO2NHMe—Ph


1267
4-F
Me
4-CF3—Ph


1268
4-F
Me
4-OMe—Ph


1269
4-F
Me
4-SMe—Ph


1270
4-F
Me
4-SOMe—Ph


1271
4-F
Me
4-SO2Me—Ph


1272
4-F
Me
4-OH—Ph


1273
4-F
Me
4-CH2OH—Ph


1274
4-F
Me
4-CHOHMe—Ph


1275
4-F
Me
4-COH(Me)2—Ph


1276
4-F
Me
4-Me—Ph


1277
4-F
Me
4-EL—Ph


1278
4-F
Me
4-iPr—Ph


1279
4-F
Me
4-tBu—Ph


1280
4-F
Me
4-CH2CO2Me—Ph


1281
4-F
Me
4-(1-piperidinyl)—Ph


1282
4-F
Me
4-(1-pyrrolidinyl)—Ph


1283
4-F
Me
4-(2-imidazolyl)—Ph


1284
4-F
Me
4-(1-imidazolyl)—Ph


1285
4-F
Me
4-(2-thiazolyl)—Ph


1286
4-F
Me
4-(3-pyrazolyl)—Ph


1287
4-F
Me
4-(1-pyrazolyl)—Ph


1288
4-F
Me
4-(5-Me-1-tetrazolyl)—Ph


1289
4-F
Me
4-(1-Me-5-tetrazolyl)—Ph


1290
4-F
Me
4-(2-pyridyl)—Ph


1291
4-F
Me
4-(2-thienyl)—Ph


1292
4-F
Me
4-(2-furanyl)—Ph


1293
4-F
Me
2-CN—Ph


1294
4-F
Me
2-COMe—Ph


1295
4-F
Me
2-CO2Me—Ph


1296
4-F
Me
2-CONH2—Ph


1297
4-F
Me
2-CONHMe—Ph


1298
4-F
Me
2-F—Ph


1299
4-F
Me
2-Cl—Ph


1300
4-F
Me
2-Br—Ph


1301
4-F
Me
2-SO2NH2—Ph


1302
4-F
Me
2-SO2NHMe—Ph


1303
4-F
Me
2-CF3—Ph


1304
4-F
Me
2-OMe—Ph


1305
4-F
Me
2-SMe—Ph


1306
4-F
Me
2-SOMe—Ph


1307
4-F
Me
2-SO2Me—Ph


1308
4-F
Me
2-OH—Ph


1309
4-F
Me
2-CH2OH—Ph


1310
4-F
Me
2-CHOHMe—Ph


1311
4-F
Me
2-COH(Me)2—Ph


1312
4-F
Me
2-Me—Ph


1313
4-F
Me
2-Et—Ph


1314
4-F
Me
2-iPr—Ph


1315
4-F
Me
2-tBu—Ph


1316
4-F
Me
2-CH2CO2Me—Ph


1317
4-F
Me
2-(1-piperidinyl)—Ph


1318
4-F
Me
2-(1-pyrrolidinyl)—Ph


1319
4-F
Me
2-(2-imidazolyl)—Ph


1320
4-F
Me
2-(1-imidazolyl)—Ph


1321
4-F
Me
2-(2-thiazolyl)—Ph


1322
4-F
Me
2-(3-pyrazolyl)—Ph


1323
4-F
Me
2-(1-pyrazolyl)—Ph


1324
4-F
Me
2-(5-Me-1-tetrazolyl)—Ph


1325
4-F
Me
2-(1-Me-5-tetrazolyl)—Ph


1326
4-F
Me
2-(2-pyridyl)—Ph


1327
4-F
Me
2-(2-thieriyl)—Ph


1328
4-F
Me
2-(2-furanyl)—Ph


1329
4-F
Me
2,4-diF—Ph


1330
4-F
Me
2,5-diF—Ph


1331
4-F
Me
2,6-diF—Ph


1332
4-F
Me
3,4-diF—Ph


1333
4-F
Me
3,5-diF—Ph


1334
4-F
Me
2,4-diCl—Ph


1335
4-F
Me
2,5-diCl—Ph


1336
4-F
Me
2,6-diCl—Ph


1337
4-F
Me
3,4-diCl—Ph


1338
4-F
Me
3,5-diCl—Ph


1339
4-F
Me
3,4-diCF3—Ph


1340
4-F
Me
3,5-diCF3—Ph


1341
4-F
Me
5-Cl-2-MeO—Ph


1342
4-F
Me
5-Cl-2-Me—Ph


1343
4-F
Me
2-F-5-Me—Ph


1344
4-F
Me
3-F-5-morpholino—Ph


1345
4-F
Me
3,4-OCH2O—Ph


1346
4-F
Me
3,4-OCH2CH2O—Ph


1347
4-F
Me
2-MeO-5-CONH2—Ph


1348
4-F
Me
2-MeO-4-(1-Me-5-tetrazolyl)—Ph


1349
4-F
Me
2-MeO-5-(1-Me-5-tetrazolyl)—Ph


1350
4-F
Me
3-CONH2-5-(1-Me-5-tetrazolyl)—Ph


1351
4-F
Me
1-naphthyl


1352
4-F
Me
2-naphthyl


1353
4-F
Me
2-thienyl


1354
4-F
Me
3-thienyl


1355
4-F
Me
2-furanyl


1356
4-F
Me
3-furanyl


1357
4-F
Me
2-pyridyl


1358
4-F
Me
3-pyridyl


1359
4-F
Me
4-pyridyl


1360
4-F
Me
2-indolyl


1361
4-F
Me
3-indolyl


1362
4-F
Me
5-indolyl


1363
4-F
Me
6-indolyl


1364
4-F
Me
3-indazolyl


1365
4-F
Me
5-indazolyl


1366
4-F
Me
6-indazolyl


1367
4-F
Me
2-imidazolyl


1368
4-F
Me
3-isoxazoyl


1369
4-F
Me
3-pyrazolyl


1370
4-F
Me
2-thiadiazolyl


1371
4-F
Me
2-thiazolyl


1372
4-F
Me
5-Ac-4-Me-2-thiazolyl


1373
4-F
Me
5-tetrazolyl


1374
4-F
Me
2-benzimidazolyl


1375
4-F
Me
5-benzimidazolyl


1376
4-F
Me
2-benzothiazolyl


1377
4-F
Me
5-benzothiazolyl


1378
4-F
Me
2-benzoxazolyl


1379
4-F
Me
5-benzoxazolyl


1380
4-F
Me
1-adamantyl


1381
4-F
Me
2-adamantyl


1382
4-F
Me
i-Pr


1383
4-F
Me
t-Bu


1384
4-F
Me
c-Hex


1385
4-F
Me
CH2CH2OMe


1386
4-F
Me
CH2CONH2


1387
4-F
Me
CH2CO2Me


1388
4-F
Me
CH(CH2Ph)CO2Me


1389
4-F
Me
CH2CH2NMe2


1390
4-F
Me
benzyl


1391
4-F
Me
phenethyl


1392
4-F
Me
2-(morpholin-1-yl)-Et


1393
3-Cl
Me
Ph


1394
3-Cl
Me
3-CN—Ph


1395
3-Cl
Me
3-COMe—Ph


1396
3-Cl
Me
3-CO2Me—Ph


1397
3-Cl
Me
3-CONH2—Ph


1398
3-Cl
Me
3-CONHMe—Ph


1399
3-Cl
Me
3-F—Ph


1400
3-Cl
Me
3-Cl—Ph


1401
3-Cl
Me
3-Br—Ph


1402
3-Cl
Me
3-SO2NH2—Ph


1403
3-Cl
Me
3-SO2NHMe—Ph


1404
3-Cl
Me
3-CF3—Ph


1405
3-Cl
Me
3-OMe—Ph


1406
3-Cl
Me
3-SMe—Ph


1407
3-Cl
Me
3-SOMe—Ph


1408
3-Cl
Me
3-SO2Me—Ph


1409
3-Cl
Me
3-OH—Ph


1410
3-Cl
Me
3-CH2OH—Ph


1411
3-Cl
Me
3-CHOHMe—Ph


1412
3-Cl
Me
3-COH(Me)2—Ph


1413
3-Cl
Me
3-Me—Ph


1414
3-Cl
Me
3-Et—Ph


1415
3-Cl
Me
3-iPr—Ph


1416
3-Cl
Me
3-tBu—Ph


1417
3-Cl
Me
3-CH2CO2Me—Ph


1418
3-Cl
Me
3-(1-piperidinyl)—Ph


1419
3-Cl
Me
3-(1-pyrrolidinyl)—Ph


1420
3-Cl
Me
3-(2-imidazolyl)—Ph


1421
3-Cl
Me
3-(1-imidazolyl)—Ph


1422
3-Cl
Me
3-(2-thiazolyl)—Ph


1423
3-Cl
Me
3-(3-pyrazolyl)—Ph


1424
3-Cl
Me
3-(1-pyrazolyl)—Ph


1425
3-Cl
Me
3-(5-Me-1-tetrazolyl)—Ph


1426
3-Cl
Me
3-(1-Me-5-tetrazolyl)—Ph


1427
3-Cl
Me
3-(2-pyridyl)—Ph


1428
3-Cl
Me
3-(2-thienyl)—Ph


1429
3-Cl
Me
3-(2-furanyl)—Ph


1430
3-Cl
Me
4-CN—Ph


1431
3-Cl
Me
4-COMe—Ph


1432
3-Cl
Me
4-CO2Me—Ph


1433
3-Cl
Me
4-CONH2—Ph


1434
3-Cl
Me
4-CONHMe—Ph


1435
3-Cl
Me
4-CONHPh—Ph


1436
3-Cl
Me
4-F—Ph


1437
3-Cl
Me
4-Cl—Ph


1438
3-Cl
Me
4-Br—Ph


1439
3-Cl
Me
4-SO2NH2—Ph


1440
3-Cl
Me
4-SO2NHMe—Ph


1441
3-Cl
Me
4-CF3—Ph


1442
3-Cl
Me
4-OMe—Ph


1443
3-Cl
Me
4-SMe—Ph


1444
3-Cl
Me
4-SOMe—Ph


1445
3-Cl
Me
4-SO2Me—Ph


1446
3-Cl
Me
4-OH—Ph


1447
3-Cl
Me
4-CH2OH—Ph


1448
3-Cl
Me
4-CHOHMe—Ph


1449
3-Cl
Me
4-COH(Me)2—Ph


1450
3-Cl
Me
4-Me—Ph


1451
3-Cl
Me
4-Et—Ph


1452
3-Cl
Me
4-iPr—Ph


1453
3-Cl
Me
4-tBu—Ph


1454
3-Cl
Me
4-CH2CO2Me—Ph


1455
3-Cl
Me
4-(1-piperidinyl)—Ph


1456
3-Cl
Me
4-(1-pyrrolidinyl)—Ph


1457
3-Cl
Me
4-(2-imidazolyl)—Ph


1458
3-Cl
Me
4-(1-imidazolyl)—Ph


1459
3-Cl
Me
4-(2-thiazolyl)—Ph


1460
3-Cl
Me
4-(3-pyrazolyl)—Ph


1461
3-Cl
Me
4-(1-pyrazolyl)—Ph


1462
3-Cl
Me
4-(5-Me-1-tetrazolyl)—Ph


1463
3-Cl
Me
4-(1-Me-5-tetrazolyl)—Ph


1464
3-Cl
Me
4-(2-pyridyl)—Ph


1465
3-Cl
Me
4-(2-thienyl)—Ph


1466
3-Cl
Me
4-(2-furanyl)—Ph


1467
3-Cl
Me
2-CN—Ph


1468
3-Cl
Me
2-COMe—Ph


1469
3-Cl
Me
2-CO2Me—Ph


1470
3-Cl
Me
2-CONH2—Ph


1471
3-Cl
Me
2-CONHMe—Ph


1472
3-Cl
Me
2-F—Ph


1473
3-Cl
Me
2-Cl—Ph


1474
3-Cl
Me
2-Br—Ph


1475
3-Cl
Me
2-SO2NH2—Ph


1476
3-Cl
Me
2-SO2NHMe—Ph


1477
3-Cl
Me
2-CF3—Ph


1478
3-Cl
Me
2-OMe—Ph


1479
3-Cl
Me
2-SMe—Ph


1480
3-Cl
Me
2-SOMe—Ph


1481
3-Cl
Me
2-SO2Me—Ph


1482
3-Cl
Me
2-OH—Ph


1483
3-Cl
Me
2-CH2OH—Ph


1484
3-Cl
Me
2-CHOHNe—Ph


1485
3-Cl
Me
2-COH(Me)2—Ph


1486
3-Cl
Me
2-Me—Ph


1487
3-Cl
Me
2-Et—Ph


1488
3-Cl
Me
2-iPr—Ph


1489
3-Cl
Me
2-tBu—Ph


1490
3-Cl
Me
2-CH2CO2Me—Ph


1491
3-Cl
Me
2-(1-piperidinyl)—Ph


1492
3-Cl
Me
2-(1-pyrrolidinyl)—Ph


1493
3-Cl
Me
2-(2-imidazolyl)—Ph


1494
3-Cl
Me
2-(1-imidazolyl)—Ph


1495
3-Cl
Me
2-(2-thiazolyl)—Ph


1496
3-Cl
Me
2-(3-pyrazolyl)—Ph


1497
3-Cl
Me
2-(1-pyrazolyl)—Ph


1498
3-Cl
Me
2-(5-Me-1-tetrazolyl)—Ph


1499
3-Cl
Me
2-(1-Me-5-tetrazolyl)—Ph


1500
3-Cl
Me
2-(2-pyridyl)—Ph


1501
3-Cl
Me
2-(2-thienyl)—Ph


1502
3-Cl
Me
2-(2-furanyl)—Ph


1503
3-Cl
Me
2,4-diF—Ph


1504
3-Cl
Me
2,5-diF—Ph


1505
3-Cl
Me
2,6-diF—Ph


1506
3-Cl
Me
3,4-diF—Ph


1507
3-Cl
Me
3,5-diF—Ph


1508
3-Cl
Me
2,4-diCl—Ph


1509
3-Cl
Me
2,5-diCl—Ph


1510
3-Cl
Me
2,6-diCl—Ph


1511
3-Cl
Me
3,4-diCl—Ph


1512
3-Cl
Me
3,5-diCl—Ph


1513
3-Cl
Me
3,4-diCF3—Ph


1514
3-Cl
Me
3,5-diCF3—Ph


1515
3-Cl
Me
5-Cl-2-MeO-Fh


1516
3-Cl
Me
5-Cl-2-Me—Ph


1517
3-Cl
Me
2-F-S-Me—Ph


1518
3-Cl
Me
3-F-5-morpholino—Ph


1519
3-Cl
Me
3,4-OCH2O—Ph


1520
3-Cl
Me
3,4-OCH2CH2O—Ph


1521
3-Cl
Me
2-MeO-5-CONH2—Ph


1522
3-Cl
Me
2-MeO-4-(1-Me-5-tetrazolyl)—Ph


1523
3-Cl
Me
2-MeO-5-(1-Me-5-tetrazolyl)—Ph


1524
3-Cl
Me
3-CONH2-5-(1-Me-5-tetrazolyl)—Ph


1525
3-Cl
Me
1-naphthyl


1526
3-Cl
Me
2-naphthyl


1527
3-Cl
Me
2-thienyl


1528
3-Cl
Me
3-thienyl


1529
3-Cl
Me
2-furanyl


1530
3-Cl
Me
3-furanyl


1531
3-Cl
Me
2-pyridyl


1532
3-Cl
Me
3-pyridyl


1533
3-Cl
Me
4-pyridyl


1534
3-Cl
Me
2-indolyl


1535
3-Cl
Me
3-indolyl


1536
3-Cl
Me
5-indolyl


1537
3-Cl
Me
6-indolyl


1538
3-Cl
Me
3-indazolyl


1539
3-Cl
Me
5-indazolyl


1540
3-Cl
Me
6-indazolyl


1541
3-Cl
Me
2-imidazolyl


1542
3-Cl
Me
3-isoxazoyl


1543
3-Cl
Me
3-pyrazolyl


1544
3-Cl
Me
2-thiadiazolyl


1545
3-Cl
Me
2-thiazolyl


1546
3-Cl
Me
5-Ac-4-Me-2-thiazolyl


1547
3-Cl
Me
5-tetrazolyl


1548
3-Cl
Me
2-benzimidazolyl


1549
3-Cl
Me
5-berazimidazolyl


1550
3-Cl
Me
2-benzothiazolyl


1551
3-Cl
Me
5-benzothiazolyl


1552
3-Cl
Me
2-benzoxazolyl


1553
3-Cl
Me
5-benzoxazolyl


1554
3-Cl
Me
1-adamantyl


1555
3-Cl
Me
2-adamantyl


1556
3-Cl
Me
i-Pr


1557
3-Cl
Me
t-Bu


1558
3-Cl
Me
c-Hex


1559
3-Cl
Me
CH2CH2OMe


1560
3-Cl
Me
CH2CONU2


1561
3-Cl
Me
CH2CO2Me


1562
3-Cl
Me
CH(CH2Ph)CO2Me


1563
3-Cl
Me
CH2CH2NNe2


1564
3-Cl
Me
benzyl


1565
3-Cl
Me
phenethyl


1566
3-Cl
Me
2-(morpholin-1-yl)-Et


1567
4-Cl
Me
Ph


1568
4-Cl
Me
3-CN—Ph


1569
4-Cl
Me
3-COMe—Ph


1570
4-Cl
Me
3-CO2Me—Ph


1571
4-Cl
Me
3-CONH2—Ph


1572
4-Cl
Me
3-CONHNe—Ph


1573
4-Cl
Me
3-F—Ph


1574
4-Cl
Me
3-Cl—Ph


1575
4-Cl
Me
3-Br—Ph


1576
4-Cl
Me
3-SO2NH2—Ph


1577
4-Cl
Me
3-SO2NHMe—Ph


1578
4-Cl
Me
3-CF3—Ph


1579
4-Cl
Me
3-OMe—Ph


1580
4-Cl
Me
3-SMe—Ph


1581
4-Cl
Me
3-SOMe—Ph


1582
4-Cl
Me
3-SO2Me—Ph


1583
4-Cl
Me
3-OH—Ph


1584
4-Cl
Me
3-CH2OH—Ph


1585
4-Cl
Me
3-CHOHMe—Ph


1586
4-Cl
Me
3-COH(Me)2—Ph


1587
4-Cl
Me
3-Me—Ph


1588
4-Cl
Me
3-Et—Ph


1589
4-Cl
Me
3-iPr—Ph


1590
4-Cl
Me
3-tBu—Ph


1591
4-Cl
Me
3-CH2CO2Me—Ph


1592
4-Cl
Me
3-(1-piperidinyl)—Ph


1593
4-Cl
Me
3-(1-pyrrolidinyl)—Ph


1594
4-Cl
Me
3-(2-imidazolyl)—Ph


1595
4-Cl
Me
3-(1-imidazolyl)—Ph


1596
4-Cl
Me
3-(2-thiazolyl)—Ph


1597
4-Cl
Me
3-(3-pyrazolyl)—Ph


1598
4-Cl
Me
3-(1-pyrazolyl)—Ph


1599
4-Cl
Me
3-(5-Me-1-tetrazolyl)—Ph


1600
4-Cl
Me
3-(1-Me-5-tetrazolyl)—Ph


1601
4-Cl
Me
3-(2-pyridyl)—Ph


1602
4-Cl
Me
3-(2-thienyl)—Ph


1603
4-Cl
Me
3-(2-furanyl)—Ph


1604
4-Cl
Me
4-CN—Ph


1605
4-Cl
Me
4-COMe—Ph


1606
4-Cl
Me
4-CO2Me—Ph


1607
4-Cl
Me
4-CONH2—Ph


1608
4-Cl
Me
4-CONHMe—Ph


1609
4-Cl
Me
4-CONHPh—Ph


1610
4-Cl
Me
4-F—Ph


1611
4-Cl
Me
4-Cl—Ph


1612
4-Cl
Me
4-Br—Ph


1613
4-Cl
Me
4-SO2NH2—Ph


1614
4-Cl
Me
4-SO2NHMe—Ph


1615
4-Cl
Me
4-CF3—Ph


1616
4-Cl
Me
4-OMe—Ph


1617
4-Cl
Me
4-SMe—Ph


1618
4-Cl
Me
4-SOMe—Ph


1619
4-Cl
Me
4-SO2Me—Ph


1620
4-Cl
Me
4-OH—Ph


1621
4-Cl
Me
4-CH2OH—Ph


1622
4-Cl
Me
4-CHOHMe—Ph


1623
4-Cl
Me
4-COH(Me)2—Ph


1624
4-Cl
Me
4-Me—Ph


1625
4-Cl
Me
4-Et—Ph


1626
4-Cl
Me
4-iPr—Ph


1627
4-Cl
Me
4-tBu—Ph


1628
4-Cl
Me
4-CH2CO2Me—Ph


1629
4-Cl
Me
4-(1-piperidinyl)—Ph


1630
4-Cl
Me
4-(1-pyrrolidinyl)—Ph


1631
4-Cl
Me
4-(2-imidazolyl)—Ph


1632
4-Cl
Me
4-(1-imidazolyl)—Ph


1633
4-Cl
Me
4-(2-thiazolyl)—Ph


1634
4-Cl
Me
4-(3-pyrazolyl)—Ph


1635
4-Cl
Me
4-(1-pyrazolyl)—Ph


1636
4-Cl
Me
4-(5-Me-1-tetrazolyl)—Ph


1637
4-Cl
Me
4-(1-Me-5-tetrazolyl)—Ph


1638
4-Cl
Me
4-(2-pyridyl)—Ph


1639
4-Cl
Me
4-(2-thienyl)—Ph


1640
4-Cl
Me
4-(2-furanyl)—Ph


1641
4-Cl
Me
2-CN—Ph


1642
4-Cl
Me
2-COMe—Ph


1643
4-Cl
Me
2-CO2Me—Ph


1644
4-Cl
Me
2-CONH2—Ph


1645
4-Cl
Me
2-CONHMe—Ph


1646
4-Cl
Me
2-F—Ph


1647
4-Cl
Me
2-Cl—Ph


1648
4-Cl
Me
2-Br—Ph


1649
4-Cl
Me
2-SO2NH2—Ph


1650
4-Cl
Me
2-SO2NHMe—Ph


1651
4-Cl
Me
2-CF3—Ph


1652
4-Cl
Me
2-OMe—Ph


1653
4-Cl
Me
2-SMe—Ph


1654
4-Cl
Me
2-SOMe—Ph


1655
4-Cl
Me
2-SO2Me—Ph


1656
4-Cl
Me
2-OH—Ph


1657
4-Cl
Me
2-CH2OH—Ph


1658
4-Cl
Me
2-CHOHMe—Ph


1659
4-Cl
Me
2-COH(Me)2—Ph


1660
4-Cl
Me
2-Me—Ph


1661
4-Cl
Me
2-Et—Ph


1662
4-Cl
Me
2-iPr—Ph


1663
4-Cl
Me
2-tBu—Ph


1664
4-Cl
Me
2-CH2CO2Me—Ph


1665
4-Cl
Me
2-(1-piperidinyl)—Ph


1666
4-Cl
Me
2-(1-pyrrolidinyl)—Ph


1667
4-Cl
Me
2-(2-imidazolyl)—Ph


1668
4-Cl
Me
2-(1-imidazolyl)—Ph


1669
4-Cl
Me
2-(2-thiazolyl)—Ph


1670
4-Cl
Me
2-(3-pyrazolyl)—Ph


1671
4-Cl
Me
2-(1-pyrazolyl)—Ph


1672
4-Cl
Me
2-(5-Me-1-tetrazolyl)—Ph


1673
4-Cl
Me
2-(1-Me-5-tetrazolyl)—Ph


1674
4-Cl
Me
2-(2-pyridyl)—Ph


1675
4-Cl
Me
2-(2-thienyl)—Ph


1676
4-Cl
Me
2-(2-furanyl)—Ph


1677
4-Cl
Me
2,4-diF—Ph


1678
4-Cl
Me
2,5-diF—Ph


1679
4-Cl
Me
2,6-diF—Ph


1680
4-Cl
Me
3,4-diF—Ph


1681
4-Cl
Me
3,5-diF—Ph


1682
4-Cl
Me
2,4-diCl—Ph


1683
4-Cl
Me
2,5-diCl—Ph


1684
4-Cl
Me
2,6-diCl—Ph


1685
4-Cl
Me
3,4-did—Ph


1686
4-Cl
Me
3,5-diCl—Ph


1687
4-Cl
Me
3,4-diCF3—Ph


1688
4-Cl
Me
3,5-diCF3—Ph


1689
4-Cl
Me
5-Cl-2-MeO—Ph


1690
4-Cl
Me
5-Cl-2-Me—Ph


1691
4-Cl
Me
2-F-5-Me—Ph


1692
4-Cl
Me
3-F-5-morpholino—Ph


1693
4-Cl
Me
3,4-OCH2O—Ph


1694
4-Cl
Me
3,4-OCH2CH2O—Ph


1695
4-Cl
Me
2-MeO-5-CONH2—Ph


1696
4-Cl
Me
2-MeO-4-(1-Me-5-tetrazolyl)—Ph


1697
4-Cl
Me
2-MeO-5-(1-Me-5-tetrazolyl)—Ph


1698
4-Cl
Me
3-CONH2-5-(1-Me-5-tetrazolyl)—Ph


1699
4-Cl
Me
1-naphthyl


1704
4-Cl
Me
3-furanyl


1705
4-Cl
Me
2-pyridyl


1706
4-Cl
Me
3-pyridyl


1707
4-Cl
Me
4-pyridyl


1708
4-Cl
Me
2-indolyl


1709
4-Cl
Me
3-indolyl


1710
4-Cl
Me
5-indolyl


1711
4-Cl
Me
6-indolyl


1712
4-Cl
Me
3-indazolyl


1713
4-Cl
Me
5-indazolyl


1714
4-Cl
Me
6-indazolyl


1715
4-Cl
Me
2-imidazolyl


1716
4-Cl
Me
3-isoxazoyl


1717
4-Cl
Me
3-pyrazolyl


1718
4-Cl
Me
2-thiadiazolyl


1719
4-Cl
Me
2-thiazolyl


1720
4-Cl
Me
5-Ac-4-Me-2-thiazolyl


1721
4-Cl
Me
5-tetrazolyl


1722
4-Cl
Me
2-benzimidazolyl


1723
4-Cl
Me
5-benzimidazolyl


1724
4-Cl
Me
2-benzothiazolyl


1725
4-Cl
Me
5-benzothiazolyl


1726
4-Cl
Me
2-benzoxazolyl


1727
4-Cl
Me
5-benzoxazolyl


1728
4-Cl
Me
1-adamantyl


1729
4-Cl
Me
2-adamantyl


1730
4-Cl
Me
i-Pr


1731
4-Cl
Me
t-Bu


1732
4-Cl
Me
c-Hex


1733
4-Cl
Me
CH2CH2OMe


1734
4-Cl
Me
CH2CONH2


1735
4-Cl
Me
CH2CO2Me


1736
4-Cl
Me
CH(CH2Ph)CO2Me


1737
4-Cl
Me
CH2CH2NMe2


1738
4-Cl
Me
benzyl


1739
4-Cl
Me
phenethyl


1740
4-Cl
Me
2-(morpholin-1-yl)-Et









Utility
The utility of the compounds in accordance with the present invention as modulators of chemokine receptor activity may be demonstrated by methodology known in the art, such as the assays for CCR-2 and CCR-3 ligand binding, as disclosed by Ponath et al., J. Exp. Med., 183, 2437-2448 (1996) and Uguccioni et al., J. Clin. Invest., 100, 1137-1143 (1997). Cell lines for expressing the receptor of interest include those naturally expressing the chemokine receptor, such as EOL-3 or THP-1, those induced to express the chemokine receptor by the addition of chemical or protein agents, such as HL-60 or AML14.3D10 cells treated with, for example, butyric acid with interleukin-5 present, or a cell engineered to express a recombinant chemokine receptor, such as CHO or HEK-293. Finally, blood or tissue cells, for example human peripheral blood eosinophils, isolated using methods as described by Hansel et al., J. Immunol. Methods, 145, 105-110 (1991), can be utilized in such assays. In particular, the compound of the present invention have activity in binding to the CCR-3 receptor in the aforementioned assays. As used herein, “activity” is intended to mean a compound demonstrating an IC50 of 10 μM or lower in concentration when measured in the aforementioned assays. Such a result is indicative of the intrinsic activity of the compounds as modulators of chemokine receptor activity. A general binding protocol is described below.
CCR3-Receptor Binding Protocol
Millipore filter plates (#MABVN1250) are treated with 5 μg/ml protamine in phosphate buffered saline, pH 7.2, for ten minutes at room temperature. Plates are washed three times with phosphate buffered saline and incubated with phosphate buffered saline for thirty minutes at room temperature. For binding, 50 μl of binding buffer (0.5% bovine serum albumen, 20 mM HEPES buffer and 5 mM magnesium chloride in RPMI 1640 media) with or without a test concentration of a compound present at a known concentration is combined with 50 μl of 125-I labeled human eotaxin (to give a final concentration of 150 pM radioligand) and 50 μl of cell suspension in binding buffer containing 5×105 total cells. Cells used for such binding assays can include cell lines transfected with a gene expressing CCR3 such as that described by Daugherty et al. (1996), isolated human eosinophils such as described by Hansel et al. (1991) or the AML14.3D10 cell line after differentiation with butyric acid as described by Tiffany et al. (1998). The mixture of compound, cells and radioligand are incubated at room temperature for thirty minutes. Plates are placed onto a vacuum manifold, vacuum applied, and plates washed three times with binding buffer with 0.5M NaCl added. The plastic skirt is removed from the plate, the plate allowed to air dry, the wells punch out and CPM counted. The percent inhibition of binding is calculated using the total count obtained in the absence of any competing compound or chemokine ligand and the background binding determined by addition of 100 nM eotaxin in place of the test compound.
The utility of the compounds in accordance with the present invention as inhibitors of the migration of eosinophils or cell lines expressing the chemokine receptors may be demonstrated by methodology known in the art, such as the chemotaxis assay disclosed by Bacon et al., Brit. J. Pharmacol., 95, 966-974 (1988). In particular, the compound of the present invention have activity in inhibition of the migration of eosinophils in the aforementioned assays. As used herein, “activity” is intended to mean a compound demonstrating an IC50 of 10 μM or lower in concentration when measured in the aforementioned assays. Such a result is indicative of the intrinsic activity of the compounds as modulators of chemokine receptor activity. A human eosinophil chemotaxis assay protocol is described below.
Human Eosinophil Chemotaxis Assay
Neuroprobe MBA96 96-well chemotaxis chambers with Neuroprobe polyvinylpyrrolidone-free polycarbonate PFD5 5-micron filters in place are warmed in a 37° C. incubator prior to assay. Freshly isolated human eosinophils, isolated according to a method such as that described by Hansel et al. (1991), are suspended in RPMI 1640 with 0.1% bovine serum albumin at 1×106 cells/ml and warmed in a 37° C. incubator prior to assay. A 20 nM solution of human eotaxin in RPMI 1640 with 0.1% bovine serum albumin is warmed in a 37° C. incubator prior to assay. The eosinophil suspension and the 20 nM eotaxin solution are each mixed 1:1 with prewarmed RPMI 1640 with 0.1% bovine serum albumin with or without a dilution of a test compound that is at two fold the desired final concentration. These mixtures are warmed in a 37° C. incubator prior to assay. The filter is separated from the prewarmed Neuroprobe chemotaxis chamber and the eotaxin/compound mixture is placed into a Polyfiltronics MPC 96 well plate that has been placed in the bottom part of the Neuro Probe chemotaxis chamber. The approximate volume is 370 microliters and there should be a positive meniscus after dispensing. The filter is replaced above the 96 well plate, the rubber gasket is attached to the bottom of the upper chamber, and the chamber assembled. A 200 μl volume of the cell suspension/compound mixture is added to the appropriate wells of the upper chamber. The upper chamber is covered with a plate sealer, and the assembled unit placed in a 37° C. incubator for 45 minutes. After incubation, the plate sealer is removed and all remaining cell suspension is aspirated off. The chamber is disassembled and, while holding the filter by the sides at a 90-degree angle, unmigrated cells are washed away using a gentle stream of phosphate buffered saline dispensed from a squirt bottle and then the filter wiped with a rubber tipped squeegee. The filter is allowed to completely dry and immersed completely in Wright Giemsa stain for 30-45 seconds. The filter is rinsed with distilled water for 7 minutes, rinsed once with water briefly, and allowed to dry. Migrated cells are enumerated by microscopy.
Mammalian chemokine receptors provide a target for interfering with or promoting immune cell function in a mammal, such as a human. Compounds that inhibit or promote chemokine receptor function are particularly useful for modulating immune cell function for therapeutic purposes. Accordingly, the present invention is directed to compounds which are useful in the prevention and/or treatment of a wide variety of inflammatory, infectious, and immunoregulatory disorders and diseases, including asthma and allergic diseases, infection by pathogenic microbes (which, by definition, includes viruses), as well as autoimmune pathologies such as the rheumatoid arthritis and atherosclerosis.
For example, an instant compound which inhibits one or more functions of a mammalian chemokine receptor (e.g., a human chemokine receptor) may be administered to inhibit (i.e., reduce or prevent) inflammation or infectious disease. As a result, one or more inflammatory process, such as leukocyte emigration, adhesion, chemotaxis, exocytosis (e.g., of enzymes, histamine) or inflammatory mediator release, is inhibited. For example, eosinophilic infiltration to inflammatory sites (e.g., in asthma or allergic rhinitis) can be inhibited according to the present method. In particular, the compound of the following examples has activity in blocking the migration of cells expressing the CCR-3 receptor using the appropriate chemokines in the aforementioned assays. As used herein, “activity” is intended to mean a compound demonstrating an IC50 of 10 μM or lower in concentration when measured in the aforementioned assays. Such a result is also indicative of the intrinsic activity of the compounds as modulators of chemokine receptor activity.
Similarly, an instant compound which promotes one or more functions of the mammalian chemokine receptor (e.g., a human chemokine) as administered to stimulate (induce or enhance) an immune or inflammatory response, such as leukocyte emigration, adhesion, chemotaxis, exocytosis (e.g., of enzymes, histamine) or inflammatory mediator release, resulting in the beneficial stimulation of inflammatory processes. For example, eosinophils can be recruited to combat parasitic infections. In addition, treatment of the aforementioned inflammatory, allergic and autoimmune diseases can also be contemplated for an instant compound which promotes one or more functions of the mammalian chemokine receptor if one contemplates the delivery of sufficient compound to cause the loss of receptor expression on cells through the induction of chemokine receptor internalization or the delivery of compound in a manner that results in the misdirection of the migration of cells.
In addition to primates, such as humans, a variety of other mammals can be treated according to the method of the present invention. For instance, mammals, including but not limited to, cows, sheep, goats, horses, dogs, cats, guinea pigs, rats or other bovine, ovine, equine, canine, feline, rodent or murine species can be treated. However, the method can also be practiced in other species, such as avian species. The subject treated in the methods above is a mammal, male or female, in whom modulation of chemokine receptor activity is desired. “Modulation” as used herein is intended to encompass antagonism, agonism, partial antagonism and/or partial agonism.
Diseases or conditions of human or other species which can be treated with inhibitors of chemokine receptor function, include, but are not limited to: inflammatory or allergic diseases and conditions, including respiratory allergic diseases such as asthma, allergic rhinitis, hypersensitivity lung diseases, hypersensitivity pneumonitis, eosinophilic cellulitis (e.g., Well's syndrome), eosinophilic pneumonias (e.g., Loeffler's syndrome, chronic eosinophilic pneumonia), eosinophilic fasciitis (e.g., Shulman's syndrome), delayed-type hypersensitivity, interstitial lung diseases (ILD) (e.g., idiopathic pulmonary fibrosis, or ILD associated with rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, systemic sclerosis, Sjogren's syndrome, polymyositis or dermatomyositis); systemic anaphylaxis or hypersensitivity responses, drug allergies (e.g., to penicillin, cephalosporins), eosinophilia-myalgia syndrome due to the ingestion of contaminated tryptophan, insect sting allergies; autoimmune diseases, such as rheumatoid arthritis, psoriatic arthritis, multiple sclerosis, systemic lupus erythematosus, myasthenia gravis, juvenile onset diabetes; glomerulonephritis, autoimmune thyroiditis, Behcet's disease; graft rejection (e.g., in transplantation), including allograft rejection or graft-versus-host disease; inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis; spondyloarthropathies; scleroderma; psoriasis (including T-cell mediated psoriasis) and inflammatory dermatoses such as an dermatitis, eczema, atopic dermatitis, allergic contact dermatitis, urticaria; vasculitis (e.g., necrotizing, cutaneous, and hypersensitivity vasculitis); eosinophilic myositis, eosinophilic fasciitis; cancers with leukocyte infiltration of the skin or organs. Other diseases or conditions in which undesirable inflammatory responses are to be inhibited can be treated, including, but not limited to, reperfusion injury, atherosclerosis, certain hematologic malignancies, cytokine-induced toxicity (e.g., septic shock, endotoxic shock), polymyositis, dermatomyositis. Infectious diseases or conditions of human or other species which can be treated with inhibitors of chemokine receptor function, include, but are not limited to, HIV.
Diseases or conditions of humans or other species which can be treated with promoters of chemokine receptor function, include, but are not limited to: immunosuppression, such as that in individuals with immunodeficiency syndromes such as AIDS or other viral infections, individuals undergoing radiation therapy, chemotherapy, therapy for autoimmune disease or drug therapy (e.g., corticosteroid therapy), which causes immunosuppression; immunosuppression due to congenital deficiency in receptor function or other causes; and infections diseases, such as parasitic diseases, including, but not limited to helminth infections, such as nematodes (round worms); (Trichuriasis, Enterobiasis, Ascariasis, Hookworm, Strongyloidiasis, Trichinosis, filariasis); trematodes (flukes) (Schistosomiasis, Clonorchiasis), cestodes (tape worms) (Echinococcosis, Taeniasis saginata, Cysticercosis); visceral worms, visceral larva migraines (e.g., Toxocara), eosinophilic gastroenteritis (e.g., Anisaki sp., Phocanema sp.), cutaneous larva migraines (Ancylostona braziliense, Ancylostoma caninum). The compounds of the present invention are accordingly useful in the prevention and treatment of a wide variety of inflammatory, infectious and immunoregulatory disorders and diseases. In addition, treatment of the aforementioned inflammatory, allergic and autoimmune diseases can also be contemplated for promoters of chemokine receptor function if one contemplates the delivery of sufficient compound to cause the loss of receptor expression on cells through the induction of chemokine receptor internalization or delivery of compound in a manner that results in the misdirection of the migration of cells.
In another aspect, the instant invention may be used to evaluate the putative specific agonists or antagonists of a G protein coupled receptor. The present invention is directed to the use of these compounds in the preparation and execution of screening assays for compounds that modulate the activity of chemokine receptors. Furthermore, the compounds of this invention are useful in establishing or determining the binding site of other compounds to chemokine receptors, e.g., by competitive inhibition or as a reference in an assay to compare its known activity to a compound with an unknown activity. When developing new assays or protocols, compounds according to the present invention could be used to test their effectiveness. Specifically, such compounds may be provided in a commercial kit, for example, for use in pharmaceutical research involving the aforementioned diseases. The compounds of the instant invention are also useful for the evaluation of putative specific modulators of the chemokine receptors. In addition, one could utilize compounds of this invention to examine the specificity of G protein coupled receptors that are not thought to be chemokine receptors, either by serving as examples of compounds which do not bind or as structural variants of compounds active on these receptors which may help define specific sites of interaction.
Combined therapy to prevent and treat inflammatory, infectious and immunoregulatory disorders and diseases, including asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis, and those pathologies noted above is illustrated by the combination of the compounds of this invention and other compounds which are known for such utilities. For example, in the treatment or prevention of inflammation, the present compounds may be used in conjunction with an anti-inflammatory or analgesic agent such as an opiate agonist, a lipoxygenase inhibitor, a cyclooxygenase-2 inhibitor, an interleukin inhibitor, such as an interleukin-1 inhibitor, a tumor necrosis factor inhibitor, an NMDA antagonist, an inhibitor or nitric oxide or an inhibitor of the synthesis of nitric oxide, a non-steroidal anti-inflammatory agent, a phosphodiesterase inhibitor, or a cytokine-suppressing anti-inflammatory agent, for example with a compound such as acetaminophen, aspirin, codeine, fentaynl, ibuprofen, indomethacin, ketorolac, morphine, naproxen, phenacetin, piroxicam, a steroidal analgesic, sufentanyl, sunlindac, interferon alpha and the like. Similarly, the instant compounds may be administered with a pain reliever; a potentiator such as caffeine, an H2-antagonist, simethicone, aluminum or magnesium hydroxide; a decongestant such as phenylephrine, phenylpropanolamine, pseudophedrine, oxymetazoline, ephinephrine, naphazoline, xylometazoline, propylhexedrine, or levodesoxy-ephedrine; and antitussive such as codeine, hydrocodone, caramiphen, carbetapentane, or dextramethorphan; a diuretic; and a sedating or non-sedating antihistamine. Likewise, compounds of the present invention may be used in combination with other drugs that are used in the treatment/prevention/suppression or amelioration of the diseases or conditions for which compound of the present invention are useful. Such other drugs may be administered, by a route and in an amount commonly used therefore, contemporaneously or sequentially with a compound of the present invention. When a compound of the present invention is used contemporaneously with one or more other drugs, a pharmaceutical composition containing such other drugs in addition to the compound of the present invention is preferred. Accordingly, the pharmaceutical compositions of the present invention include those that also contain one or more other active ingredients, in addition to a compound of the present invention. Examples of other active ingredients that may be combined with a compound of the present invention, either administered separately or in the same pharmaceutical compositions, include, but are not limited to: (a) integrin antagonists such as those for selectins, ICAMs and VLA-4; (b) steroids such as beclomethasone, methylprednisolone, betamethasone, prednisone, dexamethasone, and hydrocortisone; (c) immunosuppressants such as cyclosporin, tacrolimus, rapamycin and other FK-506 type immunosuppressants; (d) antihistamines (H1-histamine antagonists) such as bromopheniramine, chlorpheniramine, dexchlorpheniramine, triprolidine, clemastine, diphenhydramine, diphenylpyraline, tripelennamine, hydroxyzine, methdilazine, promethazine, trimeprazine, azatadine, cyproheptadine, antazoline, pheniramine pyrilamine, astemizole, terfenadine, loratadine, cetirizine, fexofenadine, descarboethoxyloratadine, and the like; (e) non-steroidal anti-asthmatics such as b2-agonists (terbutaline, metaproterenol, fenoterol, isoetharine, albuteral, bitolterol, and pirbuterol), theophylline, cromolyn sodium, atropine, ipratropium bromide, leukotriene antagonists (zafirlukast, montelukast, pranlukast, iralukast, pobilukast, SKB-102,203), leukotriene biosynthesis inhibitors (zileuton, BAY-1005); (f) non-steroidal antiinflammatory agents (NSAIDs) such as propionic acid derivatives (alminoprofen, benxaprofen, bucloxic acid, carprofen, fenbufen, fenoprofen, fluprofen, flurbiprofen, ibuprofen, indoprofen, ketoprofen, miroprofen, naproxen, oxaprozin, pirprofen, pranoprofen, suprofen, tiaprofenic acid, and tioxaprofen), acetic acid derivatives (indomethacin, acemetacin, alclofenac, clidanac, diclofenac, fenclofenac, fenclozic acid, fentiazac, furofenac, ibufenac, isoxepac, oxpinac, sulindac, tiopinac, tolmetin, zidometacin, and zomepirac), fenamic acid derivatives (flufenamic acid, meclofenamic acid, mefenamic acid, niflumic acid and tolfenamic acid), biphenylcarboxylic acid derivatives (diflunisal and flufenisal), oxicams (isoxicam, piroxicam, sudoxicam and tenoxican), salicylates (acetyl salicylic acid, sulfasalazine) and the pyrazolones (apazone, bezpiperylon, feprazone, mofebutazone, oxyphenbutazone, phenylbutazone); (g) cyclooxygenase-2 (COX-2) inhibitors; (h) inhibitors of phosphodiesterase type IV (PDE-IV); (I) other antagonists of the chemokine receptors; (j) cholesterol lowering agents such as HMG-COA reductase inhibitors (lovastatin, simvastatin and pravastatin, fluvastatin, atorvsatatin, and other statins), sequestrants (cholestyramine and colestipol), nicotonic acid, fenofibric acid derivatives (gemfibrozil, clofibrat, fenofibrate and benzafibrate), and probucol; (k) anti-diabetic agents such as insulin, sulfonylureas, biguamides (metformin), a-glucosidase inhibitors (acarbose) and glitazones (troglitazone ad pioglitazone); (l) preparations of interferons (interferon alpha-2a, interferon-2b, interferon alpha-N3, interferon beta-1a, interferon beta-1b, interferon gamma-1b); (m) antiviral compounds such as efavirenz, nevirapine, indinavir, ganciclovir, lamivudine, famciclovir, and zalcitabine; (o) other compound such as 5-aminosalicylic acid an prodrugs thereof, antimetabolites such as azathioprine and 6-mercaptopurine, and cytotoxic cancer chemotherapeutic agents. The weight ratio of the compound of the present invention to the second active ingredient may be varied and will depend upon the effective doses of each ingredient. Generally, an effective dose of each will be used. Thus, for example, when a compound of the present invention is combined with an NSAID the weight ratio of the compound of the present invention to the NSAID will generally range from about 1000:1 to about 1:1000, preferably about 200:1 to about 1:200. Combinations of a compound of the present invention and other active ingredients will generally also be within the aforementioned range, but in each case, an effective dose of each active ingredient should be used.
The compounds are administered to a mammal in a therapeutically effective amount. By “therapeutically effective amount” it is meant an amount of a compound of Formula I that, when administered alone or in combination with an additional therapeutic agent to a mammal, is effective to prevent or ameliorate the thromboembolic disease condition or the progression of the disease.
Dosage and Formulation
The compounds of this invention can be administered in such oral dosage forms as tablets, capsules (each of which includes sustained release or timed release formulations), pills, powders, granules, elixirs, tinctures, suspensions, syrups, and emulsions. They may also be administered in intravenous (bolus or infusion), intraperitoneal, subcutaneous, or intramuscular form, all using dosage forms well known to those of ordinary skill in the pharmaceutical arts. They can be administered alone, but generally will be administered with a pharmaceutical carrier selected on the basis of the chosen route of administration and standard pharmaceutical practice.
The dosage regimen for the compounds of the present invention will, of course, vary depending upon known factors, such as the pharmacodynamic characteristics of the particular agent and its mode and route of administration; the species, age, sex, health, medical condition, and weight of the recipient; the nature and extent of the symptoms; the kind of concurrent treatment; the frequency of treatment; the route of administration, the renal and hepatic function of the patient, and the effect desired. A physician or veterinarian can determine and prescribe the effective amount of the drug required to prevent, counter, or arrest the progress of the thromboembolic disorder.
By way of general guidance, the daily oral dosage of each active ingredient, when used for the indicated effects, will range between about 0.001 to 1000 mg/kg of body weight, preferably between about 0.01 to 100 mg/kg of body weight per day, and most preferably between about 1.0 to 20 mg/kg/day. Intravenously, the most preferred doses will range from about 1 to about 10 mg/kg/minute during a constant rate infusion. Compounds of this invention may be administered in a single daily dose, or the total daily dosage may be administered in divided doses of two, three, or four times daily.
Compounds of this invention can be administered in intranasal form via topical use of suitable intranasal vehicles, or via transdermal routes, using transdermal skin patches. When administered in the form of a transdermal delivery system, the dosage administration will, of course, be continuous rather than intermittent throughout the dosage regimen.
The compounds are typically administered in admixture with suitable pharmaceutical diluents, excipients, or carriers (collectively referred to herein as pharmaceutical carriers) suitably selected with respect to the intended form of administration, that is, oral tablets, capsules, elixirs, syrups and the like, and consistent with conventional pharmaceutical practices.
For instance, for oral administration in the form of a tablet or capsule, the active drug component can be combined with an oral, non-toxic, pharmaceutically acceptable, inert carrier such as lactose, starch, sucrose, glucose, methyl callulose, magnesium stearate, dicalcium phosphate, calcium sulfate, mannitol, sorbitol and the like; for oral administration in liquid form, the oral drug components can be combined with any oral, non-toxic, pharmaceutically acceptable inert carrier such as ethanol, glycerol, water, and the like. Moreover, when desired or necessary, suitable binders, lubricants, disintegrating agents, and coloring agents can also be incorporated into the mixture. Suitable binders include starch, gelatin, natural sugars such as glucose or beta-lactose, corn sweeteners, natural and synthetic gums such as acacia, tragacanth, or sodium alginate, carboxymethylcellulose, polyethylene glycol, waxes, and the like. Lubricants used in these dosage forms include sodium oleate, sodium stearate, magnesium stearate, sodium benzoate, sodium acetate, sodium chloride, and the like. Disintegrators include, without limitation, starch, methyl cellulose, agar, bentonite, xanthan gum, and the like.
The compounds of the present invention can also be administered in the form of liposome delivery systems, such as small unilamellar vesicles, large unilamellar vesicles, and multilamellar vesicles. Liposomes can be formed from a variety of phospholipids, such as cholesterol, stearylamine, or phosphatidylcholines.
Compounds of the present invention may also be coupled with soluble polymers as targetable drug carriers. Such polymers can include polyvinylpyrrolidone, pyran copolymer, polyhydroxypropylmethacrylamide-phenol, polyhydroxyethylaspartamidephenol, or polyethyleneoxide-polylysine substituted with palmitoyl residues. Furthermore, the compounds of the present invention may be coupled to a class of biodegradable polymers useful in achieving controlled release of a drug, for example, polylactic acid, polyglycolic acid, copolymers of polylactic and polyglycolic acid, polyepsilon caprolactone, polyhydroxy butyric acid, polyorthoesters, polyacetals, polydihydropyrans, polycyanoacylates, and crosslinked or amphipathic block copolymers of hydrogels.
Dosage forms (pharmaceutical compositions) suitable for administration may contain from about 1 milligram to about 100 milligrams of active ingredient per dosage unit. In these pharmaceutical compositions the active ingredient will ordinarily be present in an amount of about 0.5-95% by weight based on the total weight of the composition.
Gelatin capsules may contain the active ingredient and powdered carriers, such as lactose, starch, cellulose derivatives, magnesium stearate, stearic acid, and the like. Similar diluents can be used to make compressed tablets. Both tablets and capsules can be manufactured as sustained release products to provide for continuous release of medication over a period of hours. Compressed tablets can be sugar coated or film coated to mask any unpleasant taste and protect the tablet from the atmosphere, or enteric coated for selective disintegration in the gastrointestinal tract.
Liquid dosage forms for oral administration can contain coloring and flavoring to increase patient acceptance.
In general, water, a suitable oil, saline, aqueous dextrose (glucose), and related sugar solutions and glycols such as propylene glycol or polyethylene glycols are suitable carriers for parenteral solutions. Solutions for parenteral administration preferably contain a water soluble salt of the active ingredient, suitable stabilizing agents, and if necessary, buffer substances. Antioxidizing agents such as sodium bisulfite, sodium sulfite, or ascorbic acid, either alone or combined, are suitable stabilizing agents. Also used are citric acid and its salts and sodium EDTA. In addition, parenteral solutions can contain preservatives, such as benzalkonium chloride, methyl- or propyl-paraben, and chlorobutanol.
Suitable pharmaceutical carriers are described in Remington's Pharmaceutical Sciences, Mack Publishing Company, a standard reference text in this field.
Representative useful pharmaceutical dosage-forms for administration of the compounds of this invention can be illustrated as follows:
Capsules
A large number of unit capsules can be prepared by filling standard two-piece hard gelatin capsules each with 100 milligrams of powdered active ingredient, 150 milligrams of lactose, 50 milligrams of cellulose, and 6 milligrams magnesium stearate.
Soft Gelatin Capsules
A mixture of active ingredient in a digestable oil such as soybean oil, cottonseed oil or olive oil may be prepared and injected by means of a positive displacement pump into gelatin to form soft gelatin capsules containing 100 milligrams of the active ingredient. The capsules should be washed and dried.
Tablets
Tablets may be prepared by conventional procedures so that the dosage unit is 100 milligrams of active ingredient, 0.2 milligrams of colloidal silicon dioxide, 5 milligrams of magnesium stearate, 275 milligrams of microcrystalline cellulose, 11 milligrams of starch and 98.8 milligrams of lactose. Appropriate coatings may be applied to increase palatability or delay absorption.
Injectable
A parenteral composition suitable for administration by injection may be prepared by stirring 1.5% by weight of active ingredient in 10% by volume propylene glycol and water. The solution should be made isotonic with sodium chloride and sterilized.
Suspension
An aqueous suspension can be prepared for oral administration so that each 5 mL contain 100 mg of finely divided active ingredient, 200 mg of sodium carboxymethyl cellulose, 5 mg of sodium benzoate, 1.0 g of sorbitol solution, U.S.P., and 0.025 mL of vanillin.
Where the compounds of this invention are combined with other anticoagulant agents, for example, a daily dosage may be about 0.1 to 100 milligrams of the compound of Formula I and about 1 to 7.5 milligrams of the second anticoagulant, per kilogram of patient body weight. For a tablet dosage form, the compounds of this invention generally may be present in an amount of about 5 to 10 milligrams per dosage unit, and the second anti-coagulant in an amount of about 1 to 5 milligrams per dosage unit.
Where two or more of the foregoing second therapeutic agents are administered with the compound of Formula I, generally the amount of each component in a typical daily dosage and typical dosage form may be reduced relative to the usual dosage of the agent when administered alone, in view of the additive or synergistic effect of the therapeutic agents when administered in combination.
Particularly when provided as a single dosage unit, the potential exists for a chemical interaction between the combined active ingredients. For this reason, when the compound of Formula I and a second therapeutic agent are combined in a single dosage unit they are formulated such that although the active ingredients are combined in a single dosage unit, the physical contact between the active ingredients is minimized (that is, reduced). For example, one active ingredient may be enteric coated. By enteric coating one of the active ingredients, it is possible not only to minimize the contact between the combined active ingredients, but also, it is possible to control the release of one of these components in the gastrointestinal tract such that one of these components is not released in the stomach but rather is released in the intestines. One of the active ingredients may also be coated with a material which effects a sustained-release throughout the gastrointestinal tract and also serves to minimize physical contact between the combined active ingredients. Furthermore, the sustained-released component can be additionally enteric coated such that the release of this component occurs only in the intestine. Still another approach would involve the formulation of a combination product in which the one component is coated with a sustained and/or enteric release polymer, and the other component is also coated with a polymer such as a lowviscosity grade of hydroxypropyl methylcellulose (HPMC) or other appropriate materials as known in the art, in order to further separate the active components. The polymer coating serves to form an additional barrier to interaction with the other component.
These as well as other ways of minimizing contact between the components of combination products of the present invention, whether administered in a single dosage form or administered in separate forms but at the same time by the same manner, will be readily apparent to those skilled in the art, once armed with the present disclosure.
As will be apparent to one skilled in the art, numerous modifications and variations of the present invention are possible in light of the above teachings. It is therefore to be understood that within the scope of the appended claims, the invention may be practiced otherwise than as specifically described herein.

## Claims

1. A compound of formula (I): 



or stereoisomers or pharmaceutically acceptable salts thereof, wherein: 
M is absent; 
Q is selected from CH2, CHR5, CHR13, CR13R13, and CR5R13; 
K is selected from CH2, CHR5, CHR6, CR6R6 and CR5R6; 
L is selected from CHR5 and CR5R6; 
J is selected from CH2, CHR5, CHR13, and CR5R13; 
Z is selected from O, S, NR1a, C(CN)2, CH(NO2), and CHCN; 
R1a is selected from H, C1-6 alkyl, C3-6 cycloalkyl, CONR1bR1b, OR1b, CN, NO2, and (CH2)wphenyl; 
R1b is independently selected from H, C1-3 alkyl, C3-6 cycloalkyl, and phenyl; 




G is selected from a bond, C═O, and SO2; 
Ring B is a 5, 6, or 7 membered saturated heterocyclic ring wherein the heterocycle ring includes —NR9—, —O—, —S(O)p—, —NR9dC(O)—, —C(O)NR9d—, —C(O)O—, —OC(O)—, —NR9dC(O)NR9d, —NR9dC(O)O—, —NR9dS(O)2—, —S(O)2NR9d, or —OC(O)NR9d—, the heterocycle ring being optionally substituted by 0-2 R8; 
R1 and R2 are independently selected from H, C1-8 alkyl, C3-8 alkenyl, C3-8 alkynyl, and (CH2)rC3-6 cycloalkyl; 
R3 is selected from methyl substituted with 0-1 R10, C2-8 alkyl substituted with 0-3 R7, C3-8 alkenyl substituted with 0-3 R7, C3-8 alkynyl substituted with 0-3 R7, C2 fluoroalkyl, C3-8 haloalkyl, a (CR3′R3′′)r—C3-10 carbocyclic residue substituted with 0-5 R15 and a (CR3′R3′′)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R15; 
R3′ and R3′′, at each occurrence, are selected from H, C1-6alkyl, (CH2)rC3-6 cycloalkyl, and phenyl; 
R4 is absent, taken with the nitrogen to which it is attached to form an N-oxide, or selected from C1-8 alkyl, C3-8 alkenyl, C3-8 alkynyl, (CH2)rC3-6 cycloalkyl, (CH2)qC(O)R4b, (CH2)qC(O)NR4aR4a′, (CH2)qC(O)OR4b, and a (CH2)r—C3-10 carbocyclic residue substituted with 0-3 R4c; 
R4a and R4a′, at each occurrence, are selected from H, C1-6 alkyl, (CH2)rC3-6 cycloalkyl, and phenyl; 
R4b, at each occurrence, is selected from C1-6 alkyl, C3-8 alkenyl, (CH2)rC3-6 cycloalkyl, C3-8 alkynyl, and phenyl; 
R4c, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)rOH, (CH2)rSC1-5 alkyl, (CH2)rNR4aR4a′, and (CH2)rphenyl; 
R5 is selected from a (CR5′R5′′)t—C3-10 carbocyclic residue substituted with 0-5 R16 and a (CR5′R5′′)t-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R16; 
R5′ and R5′′, at each occurrence, are selected from H, C1-6alkyl, (CH2)rC3-6 cycloalkyl, and phenyl; 
R6, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, (CF2)rCF3, CN, (CH2)rNR6aR6a′, (CH2)rOH, (CH2)rOR6b, (CH2)rSH, (CH2)rSR6b, (CH2)rC(O)OH, (CH2)rC(O)R6b, (CH2)rC(O)NR6aR6a′, (CH2)rNR6dC(O)R6a, (CH2)rC(O)OR6b, (CH2)rOC(O)R6b, (CH2)rS(O)pR6b, (CH2)rS(O)2NR6aR6a′, (CH2)rNR6dS(O)2R6b, and (CH2)tphenyl substituted with 0-3 R6c; 
R6a and R6a′, at each occurrence, are selected from H, C1-6alkyl, C3-6 cycloalkyl, and phenyl substituted with 0-3 R6c; 
R6b, at each occurrence, is selected from C1-6 alkyl, C3-6cycloalkyl, and phenyl substituted with 0-3 R6c; 
R6c, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)rOH, (CH2)rSC1-5 alkyl, and (CH2)rNR6dR6d; 
R6d, at each occurrence1 is selected from H, C1-6 alkyl, and C3-6 cycloalkyl; 
with the proviso that when any of J or K is CR6R6 and R6 is cyano, or bonded to the carbon to which it is attached through a heteroatom, the other R6 is not cyano, or bonded to the carbon to which it is attached through a heteroatom; 
R7 is selected from NO2, CN, NR7aR7a′, OH, OR7d, C(O)H, C(O)OH, C(O)R7b, C(O)NR7aR7a′, NR7fC(O)OR7d, OC(O)NR7aR7a′, NR7fC(O)R7b, NR7fC(O)NR7fR7f, C(O)OR7d, OC(O)R7b, C(═NR7f)NR7aR7a′, NHC(═NR7f)NR7fR7f, S(O)pR7b, S(O)2NR7aR7a′, NR7fS(O)2R7b, C1-6 haloalkyl; 
R7a and R7a′, at each occurrence, are selected from H, C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)r—C3-10 carbocyclic residue substituted with 0-5 R7e, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R7e; 
alternatively, R7a and R7a′, along with the N to which they are attached, join to form a 5-6 membered heterocyclic system containing 1-2 heteroatoms selected from NR7h, O, and S and optionally fused with a benzene ring or a 6-membered aromatic heterocycle; 
R7b, at each occurrence, is selected from H, C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)r—C3-6 carbocyclic residue substituted with 0-3 R7e, and (CH2)r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R7e; 
R7d, at each occurrence, is selected from C3-8 alkenyl, C3-8 alkynyl, methyl, CF3, C2-6 alkyl substituted with 0-3 R7e, a (CH2)r—C3-10 carbocyclic residue substituted with 0-3 R7e, and a (CH2)r5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R7e; 
R7e, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, C(O)C1-6 alkyl, C(O)OC1-6 alkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, OH, SH, (CH2)rSC1-5 alkyl, (CH2)rNR7fR7f, (CH2)rphenyl, and a heterocycle substituted with 0-1 R7g, wherein the heterocycle is selected from imidazole, thiazole, oxazole, pyrazole, 1,2,4-triazole, 1,2,3-triazole, isoxazole, and tetrazole,; 
R7f, at each occurrence, is selected from H, C1-6 alkyl, C3-6 cycloalkyl, and phenyl; 
R7g is selected from methyl, ethyl, acetyl, and CF3; 
R7h is selected from H, C1-6 alkyl, C3-6 cycloalkyl, (CH2)rphenyl, C(O)R7f, C(O)OR7i, and SO2R7i; 
R7i, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl; 
R8 is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, C1-6 haloalkyl, a (CH2)r—C3-10 carbocyclic residue substituted with 0-3 R8c, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R8c; 
R8a, at each occurrence, are selected from H, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, a (CH2)r—C3-10 carbocyclic residue substituted with 0-5 R8e, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R8e; 
R8b, at each occurrence, is selected from C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)r—C3-6 carbocyclic residue substituted with 0-2 R8e, and a (CH2)r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R8e; 
R8c, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, Cl, Br, I, F, (CF2)rCF3, NO2, CN, (CH2)rNR8fR8f, (CH2)rOH, (CH2)rOC1-4 alkyl, (CH2)rSC1-4 alkyl, (CH2)rC(O)OH, (CH2)rC(O)R8a, (CH2)rC(O)NR8fR8f, (CH2)rNR8fC(O)R8a, (CH2)rC(O)OC1-4 alkyl, (CH2)rOC(O)R8b, (CH2)rS(O)pR8b, (CH2)rS(O)2NR8fR8f, (CH2)rNR8fS(O)2R8b, and (CH2)rphenyl substituted with 0-3 R8e; 
R8e, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)rOH, (CH2)rSH, (CH2)rSC1-5 alkyl, (CH2)rNR8fR8f, and (CH2)rphenyl; 
R8f, at each occurrence, is selected from H, C1-6 alkyl, and C3-6 cycloalkyl; 
R9 is selected from H, CH3, C2-6 alkyl substituted with 0-3 R9a, C3-8 alkenyl, C3-8 alkynyl, C1-6 haloalkyl, (CHR′)rC(O)C1-6 alkyl substituted with 0-3 R9j, (CHR′)rC(O)OC1-6 alkyl substituted with 0-3 R9b, (CHR′)rC(O)NR9dR9d′, (CHR′)rS(O)2C1-6 alkyl, S(O)2C1-6 haloalkyl, (CHR′)rS(O)2NR9dR9d, R9′, (CHR′)rC(O)R9′, (CHR′)rC(O)NR9dR9′, (CHR′)rS(O)2R9′, and (CHR′)rS(O)2NR9dR9′; 
R9′, at each occurrence, is independently selected from (CHR′)rC3-6 cycloalkyl substituted with 0-3 R9e, (CHR′)rphenyl substituted with 0-3 R9c, (CHR′)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R9c, 
R9a, at each occurrence, is selected from CN, NO2, OC1-5 alkyl, CF3, OH, OC1-5 alkyl, OC(O)C1-5 alkyl, SC1-5 alkyl, S(O)pC1-5 alkyl, and NR9dR9d′; 
R9b, at each occurrence, is selected from C3-6 cycloalkyl, CN, (CF2)rCF3, (CH2)qOC1-5 alkyl, (CH2)qOH, (CH2)qSC1-5 alkyl, (CH2)rS(O)pC1-5 alkyl, and (CH2)qNR9dR9d′; 
R9c, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CHR′)rC(O)C1-5 alkyl, (CHR′)rC(O)OC1-5 alkyl, (CHR′)rC(O)NR9dR9d′, (CH2)rOH, (CH2)rSC1-5 alkyl, (CH2)rS(O)pC1-5 alkyl, and (CH2)rNR9dR9d′; 
provided that if R9c is attached to a carbon attached to the nitrogen on Ring B, then R9c is selected from (CH2)qOH, (CH2)qOC1-5 alkyl, (CH2)qSC1-5 alkyl, (CH2)qS(O)qC1-5 alkyl, and (CH2)qNR9dR9d′; 
R9d and R9d′, at each occurrence, are independently selected from H, C1-6 alkyl, C3-6 cycloalkyl, and phenyl; 
alternatively, R9d and R9d′, along with the N to which they are attached, join to form a 5-6 membered heterocyclic system containing 1-2 heteroatoms selected from NR9h, O, and S and optionally fused with a benzene ring or a 6-membered aromatic heterocycle; 
R9e, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5alkyl, (CHR′)rC(O)OC1-5 alkyl, (CHR′)rC(O)NR9dR9d′, (CH2)rOH, (CH2)rSC1-5 alkyl, (CH2)rS(O)pC1-5 alkyl, and (CH2)rNR9dR9d′, or alternatively, two R9e on the same carbon atom form ═O; 
R9h is selected from H, C1-5 alkyl, C3-6 cycloalkyl, (CH2)rphenyl, C(O)R9f, C(O)OR9i, and SO2R9i; 
R9i, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl; 
R9j, at each occurrence, is selected from C3-6 cycloalkyl, CN, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)rOH, (CH2)rSC1-5 alkyl, (CH2)rS(O)pC1-5 alkyl, and (CH2)rNR9dR9d′; 
R10 is selected from C(O)H, C(O)OH, C(O)R10b, C(O)NR10aR10a′, C(O)OR10d, C(═NR10f) NR10aR10a′, S(O)R10b, S(O)2R10b, S(O)2NR10aR10a′; 
R10a and R10a′, at each occurrence, are selected from H, C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)r—C3-10 carbocyclic residue substituted with 0-5 R10e, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R10e; 
alternatively, R10a and R10a′, along with the N to which they are attached, join to form a 5-6 membered heterocyclic system containing 1-2 heteroatoms selected from NR10h, O, and S and optionally fused with a benzene ring or a 6-membered aromatic heterocycle; 
R10b, at each occurrence, is selected from C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)r—C3-6 carbocyclic residue substituted with 0-3 R10e, and (CH2)r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R10e; 
R10d, at each occurrence, is selected from C3-8 alkenyl, C3-8 alkynyl, methyl, CF3, C2-6 alkyl substituted with 0-3 R10e, a (CH2)r—C3-10 carbocyclic residue substituted with 0-3 R10e, and a (CH2)r5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R10e; 
R10a, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, C(O)C1-6 alkyl, C(O)OC1-6 alkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, OH, SH, (CH2)rSC1-5 alkyl, (CH2)rNR10fR10f, (CH2)rphenyl, and a heterocycle substituted with 0-1 R10g, wherein the heterocycle is selected from imidazole, thiazole, oxazole, pyrazole, 1,2,4-triazole, 1,2,3-triazole, isoxazole, and tetrazole,; 
R10f, at each occurrence, is selected from H, C1-6 alkyl, C3-6 cycloalkyl, and phenyl; 
R10g is selected from methyl, ethyl, acetyl, and CF3; 
R10h is selected from H, C1-6 alkyl, C3-6 cycloalkyl, (CH2)rphenyl, C(O)R10f, C(O)OR10i, and SO2R10i; 
R10i, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl; 
R13, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-6 cycloalkyl, (CF2)wCF3, (CH2)qNR13aR13a′, (CH2)qOH, (CH2)qOR13b, (CH2)qSH, (CH2)qSR13b, (CH2)wC(O)OH, (CH2)wC(O)R13b, (CH2)wC(O)NR13aR13a′, (CH2)qNR13dC(O)R13a, (CH2)wC(O)OR13b, (CH2)qOC(O)R13b, (CH2)wS(O)pR13b, (CH2)wS(O)2NR13aR13a′, (CH2)qNR13dS(O)2R13b, and (CH2)w-phenyl substituted with 0-3 R13c; 
R13a and R13a′, at each occurrence, are selected from H, C1-6 alkyl, C3-6 cycloalkyl, and phenyl substituted with 0-3 R13c; 
R13b, at each occurrence, is selected from C1-6 alkyl, C3-6cycloalkyl, and phenyl substituted with 0-3 R13c; 
R13c, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)rOH, (CH2)rSC1-5 alkyl, and (CH2)rNR13dR13d; 
R13d, at each occurrence, is selected from H, C1-6 alkyl, and C3-6 cycloalkyl; 
R15, at each occurrence, is selected from ═O, C1-8 alkyl, (CH2)rC3-6 cycloalkyl, Cl, Br, I, F, NO2, CN, (CHR′)rNR15aR15a′, (CHR′)rOH, (CHR′)rO(CHR′)rR15d, (CHR′)rSH, (CHR′)rC(O)H, (CHR′)rC(O)OH, (CHR′)rC(O)(CHR′)rR15b, (CHR′)rC(O)NR15aR15a′, (CHR′)rNR15fC(O)O(CHR′)rR15d, (CHR′)rOC(O)NR15aR15a′, (CHR′)rNR15fC(O)(CHR′)rR15b, (CHR′)rNR15fC(O)NR15fR15f, (CHR′)rC(O)O(CHR′)rR15d, (CHR′)rOC(O)(CHR′)rR15b, (CHR′)rC(═NR15f)NR15aR15a′, (CHR′)rNHC(═NR15f)NR15fR15f, (CHR′)rS(O)p(CHR′)rR15b, (CHR′)rS(O)2NR15aR15a′, (CHR′)rNR15fS(O)2(CHR′)rR15b, C1-6 haloalkyl, C2-8 alkenyl substituted with 0-3 R′, C2-8 alkynyl substituted with 0-3 R′, (CHR′)rphenyl substituted with 0-3 R15e, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R15e; 
R′, at each occurrence, is independently selected from H, C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, (CH2)rC3-6 cycloalkyl, and (CH2)rphenyl substituted with R15e; 
R15a and R15a′, at each occurrence, are selected from H, C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)r—C3-10 carbocyclic residue substituted with 0-5 R15e, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R15e; 
alternatively, R15a and R15a′, along with the N to which they are attached, join to form a 5-6 membered heterocyclic system containing 1-2 heteroatoms selected from NR15h, O, and S and optionally fused with a benzene ring or a 6-membered aromatic heterocycle; 
R15b, at each occurrence, is selected from C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)r—C3-6 carbocyclic residue substituted with 0-3 R15e, and (CH2)r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R15e; 
R15d, at each occurrence, is selected from C3-8 alkenyl, C3-8 alkynyl, methyl, CF3, C2-6 alkyl substituted with 0-3 R15e, a (CH2)r—C3-10 carbocyclic residue substituted with 0-3 R15e, and a (CH2)r5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R15e; 
R15e, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, C(O)C1-6 alkyl, C(O)OC1-6 alkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, OH, SH, (CH2)rSC1-5 alkyl, (CH2)rNR15fR15f, (CH2)rphenyl, and a heterocycle substituted with 0-1 R15g, wherein the heterocycle is selected from imidazole, thiazole, oxazole, pyrazole, 1,2,4-triazole, 1,2,3-triazole, isoxazole, and tetrazole,; 
R15f, at each occurrence, is selected from H, C1-6 alkyl, C3-6 cycloalkyl, and phenyl; 
R15g is selected from methyl, ethyl, acetyl, and CF3; 
R15h is selected from H, C1-6 alkyl, C3-6 cycloalkyl, (CH2)rphenyl, C(O)R15f, C(O)OR15i, and SO2R15i; 
R15i, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl; 
R16, at each occurrence, is selected from C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, Cl, Br, I, F, NO2, CN, (CHR′)rNR16aR16a′, (CHR′)rOH, (CHR′)rO(CHR′)rR16d, (CHR′)rSH, (CHR′)rC(O)H, (CHR′)rC(O)OH, (CHR′)rC(O)(CHR′)rR16b, (CHR′)rC(O)NR16aR16a′, (CHR′)rNR16fC(O)(CHR′)rR16b, (CHR′)rC(O)O(CHR′)rR16d, (CHR′)rOC(O)(CHR′)rR16b, (CHR′)rC(═NR16f)NR16aR16a′, (CHR′)rNHC(=NR16f)NR16fR16f, (CHR′)rS(O)p(CHR′)rR16b, (CHR′)rS(O)2NR16aR16a′, (CHR′)rNR16fS(O)2(CHR′)rR16b, C1-6 haloalkyl, C2-8 alkenyl substituted with 0-3 R′, C2-8 alkynyl substituted with 0-3 R′, and (CHR′)rphenyl substituted with 0-3 R16e; 
R16a and R16a′, at each occurrence, are selected from H, C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)r—C3-10 carbocyclic residue substituted with 0-5 R16e, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R16e; 
alternatively, R16a and R16a′, along with the N to which they are attached, join to form a 5-6 membered heterocyclic system containing 1-2 heteroatoms selected from NR16h, O, and S and optionally fused with a benzene ring or a 6-membered aromatic heterocycle; 
R16b, at each occurrence, is selected from C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)rC3-6 carbocyclic residue substituted with 0-3 R16e, and a (CH2)r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R16e; 
R16d, at each occurrence, is selected from C3-8 alkenyl, C3-8 alkynyl, C1-6 alkyl substituted with 0-3 R16e, a (CH2)r—C3-10 carbocyclic residue substituted with 0-3 R16e, and a (CH2)r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R16e; 
R16e, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, OH, SH, (CH2)rSC1-5 alkyl, (CH2)rNR16fR16f, and (CH2)rphenyl; 
R16f, at each occurrence, is selected from H, C1-5 alkyl, and C3-6 cycloalkyl, and phenyl; 
R16h is selected from H, C1-6 alkyl, C3-6 cycloalkyl, (CH2)rphenyl, C(O)R16f, C(O)OR16i, and SO2R16i; 
R16i, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl; 
m, at each occurrence, is independently selected from 0, 1, and 2; 
t, at each occurrence, is independently selected from 1 and 2; 
w, at each occurrence, is independently selected from 0 and 1; 
r, at each occurrence, is independently selected from 0, 1, 2, 3, 4, and 5; 
q, at each occurrence, is independently selected from 1, 2, 3, 4, and 5; and 
p, at each occurrence, is independently selected from 0, 1, and 2.

2. The compound of claim 1, wherein:
R4 is absent, taken with the nitrogen to which it is attached to form an N-oxide, or selected from C1-8 alkyl, (CH2)rC3-6 cycloalkyl, and (CH2)r-phenyl substituted with 0-3 R4c; 
R4c, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)rOH, (CH2)rSC1-5 alkyl, (CH2)rNR4aR4a′, and (CH2)rphenyl; 
R1 and R2 are independently selected from H and C1-4 alkyl; 
R6, at each occurrence, is selected from C1-4 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, (CF2)rCF3, CN, (CH2)rOH, (CH2)rOR6b, (CH2)rC(O)R6b, (CH2)rC(O)NR6aR6a′, (CH2)rNR6dC(O)R6a, and (CH2)tphenyl substituted with 0-3 R6c; 
R6a and R6a′, at each occurrence, are selected from H, C1-6alkyl, C3-6 cycloalkyl, and phenyl substituted with 0-3 R6c; 
R6b, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl, and phenyl substituted with 0-3 R6c; 
R6c, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)rOH, (CH2)rSC1-5 alkyl, and (CH2)rNR6dR6d; 
R6d, at each occurrence, is selected from H, C1-6 alkyl, and C3-6 cycloalkyl; 
R13, at each occurrence, is selected from C1-4 alkyl, C3-6 cycloalkyl, (CH2)NR13aR13a′, (CH2)OH, (CH2)OR13b, (CH2)wC(O)R13b, (CH2)wC(O)NR13aR13a′, (CH2)NR13dC(O)R13a, (CH2)wS(O)2NR13aR13a′, (CH2)NR13dS(O)2R13b, and (CH2)w-phenyl substituted with 0-3 R13c; 
R13a and R13a′, at each occurrence, are selected from H, C1-6 alkyl, C3-6 cycloalkyl, and phenyl substituted with 0-3 R13c; 
R13b, at each occurrence, is selected from C1-6 alkyl, C3-6cycloalkyl, and phenyl substituted with 0-3 R13c; 
R13c, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)rOH, and (CH2)rNR13dR13d; 
R13d, at each occurrence, is selected from H, C1-6 alkyl, and C3-6 cycloalkyl; 
q is selected from 1, 2, and 3; and 
r is selected from 0, 1, 2, and 3.

3. The compound of claim 2, wherein:
R3 is selected from a methyl substituted with 0-1 R10, C2-8 alkyl substituted with 0-3 R7, a (CR3′H)r-carbocyclic residue substituted with 0-5 R15, wherein the carbocyclic residue is selected from phenyl, C3-6 cycloalkyl, naphthyl, and adamantyl; and a (CR3′H)r-heterocyclic system substituted with 0-3 R15, wherein the heterocyclic system is selected from pyridinyl, thiophenyl, furanyl, indazolyl, benzothiazolyl, benzimidazolyl, benzothiophenyl, benzofuranyl, benzoxazolyl, benzisoxazolyl, quinolinyl, isoquinolinyl, imidazolyl, indazolyl, isoxazolinyl, morpholinyl, pyrrolidinyl, tetrahydropyranyl, tetrahycrofuranyl, indolyl, indolinyl, isoindolyl, isothiadiazolyl, isoxazolyl, piperidinyl, pyrrazolyl, 1,2,4-triazolyl, 1,2,3-triazolyl, tetrazolyl, thiadiazolyl, thiazolyl, oxazolyl, pyrazinyl, and pyrimidinyl; and 
R5 is selected from (CR5′H)t-phenyl substituted with 0-5 R16; and a (CR5′H)t-heterocyclic system substituted with 0-3 R16, wherein the heterocyclic system is selected from pyridinyl, thiophenyl, furanyl, indazolyl, benzothiazolyl, benzimidazolyl, benzothiophenyl, benzofuranyl, benzoxazolyl, benzisoxazolyl, quinolinyl, isoquinolinyl, imidazolyl, indolyl, indolinyl, isoindolyl, isothiadiazolyl, isoxazolyl, piperidinyl, pyrrazolyl, 1,2,4-triazolyl, 1,2,3-triazolyl, tetrazolyl, thiadiazolyl, thiazolyl, oxazolyl, pyrazinyl, and pyrimidinyl.

4. The compound of claim 3, wherein
Ring B is a 5 or 6 membered heterocycle ring wherein the heterocycle ring includes —NR9—, —O—, —S(O)p—, —NR9dC(O)—, —C(O)NR9d—, —C(O)O—, —OC(O)—, —NR9dC(O)NR9d, —NR9dC(O)O—, —OC(O)NR9d—, —NR9dS(O)2—, or —S(O)2NR9d, the heterocycle ring being optionally substituted by 0-2 R8; 
R9 is selected from H, CH3, C2-6 alkyl substituted with 0-3 R9a, C3-8 alkenyl, C3-8 alkynyl, C1-3 haloalkyl, (CH2)rC(O)C1-6 alkyl substituted with 0-2 R9j, (CH2)rC(O)OC1-6 alkyl substituted with 0-3 R9b, (CH2)rC(O)NR9dR9d′, (CH2)rS(O)2C1-6 alkyl, S(O)2C1-6 trifluoromethyl, (CH2)rC(O)R9′, (CH2)rC(O)NR9dR9′, (CH2)rS(O)2R9′, R9′, and (CH2)rS(O)2NR9dR9′; 
R9′, at each occurrence, is independently selected from (CHR′)rC3-6 cycloalkyl substituted with 0-3 R9e, wherein the cycloalkyl is selected from cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl, (CHR′)rphenyl substituted with 0-3 R9c, (CHR′)r5-6 membered heterocycle system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R9c, wherein the heterocycle is selected from oxadiazolyl, morpholinyl, piperidinyl, tetrahydropyranyl, tetrahydrothiopyranyl, tetrahydrothiopyranyl dioxide, thiophene, imidazolyl, pyrrolidinyl, pyrrolyl, thiazolyl, and furanyl, and (CHR′)rphenyl substituted with 0-3 R9c; 
R9a, at each occurrence, is selected from CN, O-methyl, O-ethyl, CF3, OH, OC(O)-methyl, S-methyl, S-ethyl, S-propyl, S(O)p-methyl, S(O)p-ethyl, S(O)p-propyl, and NR9dR9d′; 
R9b, at each occurrence, is selected from cyclopropyl, cyclbutyl, cyclpentyl, CN, CF3, OH2—OC1-5 alkyl, CH2—OH, CH2—SC1-5 alkyl, and CH2—NR9dR9d′; 
R9c, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)rC(O)OC1-5 alkyl, (CH2)rC(O)C1-5 alkyl, (CH2)rC(O)NR9dR9d′, (CH2)rOH, (CH2)rSC1-5 alkyl, (CH2)rS(O)pC1-5 alkyl, and (CH2)rNR9dR9d′; 
provided that if R9c is attached to a carbon attached to the nitrogen on Ring B, then R9c is selected from (CH2)qOH, (CH2)qOC1-5 alkyl, (CH2)qSC1-5 alkyl, (CH2)qS(O)qC1-5 alkyl, and (CH2)qNR9dR9d′; 
R9d and R9d′, at each occurrence, are independently selected from H, methyl, ethyl, propyl, i-propyl, butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and phenyl; 
R9e, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)rC(O)OC1-5 alkyl, (CH2)rC(O)NR9dR9d′, (CH2)rOH, (CH2)rSC1-5 alkyl, (CH2)rS(O)pC1-5 alkyl, and (CH2)rNR9dR9d′, or alternatively, two R9e on the same carbon atom form ═O; and 
R9j, at each occurrence, is selected from cyclpropyl, cyclobutyl, cyclopentyl, CN, CF3, O-methyl, O-ethyl, O-propyl, O-i-propyl, O-butyl, OH, S-methyl, S-ethyl, and NR9dR9d′.

5. The compound of claim 4, wherein the compound of formula (I) is: 



Z is selected from O, S, NCN, and NCONH2; 
R16, at each occurrence, is selected from C1-8 alkyl, (CH2)rC3-6 cycloalkyl, CF3, Cl, Br, I, F, (CH2)rNR16aR16a′, NO2, CN, OH, (CH2)rOR16d, (CH2)rC(O)R16b, (CH2)rC(O)NR16aR16a′, (CH2)rNR16fC(O)R16b, (CH2)rS(O)pR16b, (CH2)rS(O)2NR16aR16a′, (CH2)rNR16fS(O)2R16b, and (CH2)rphenyl substituted with 0-3 R16e; 
R16a and R16a′, at each occurrence, are selected from H, C1-6 alkyl, C3-6 cycloalkyl, and (CH2)rphenyl substituted with 0-3 R16e; 
R16b, at each occurrence, is selected from H, C1-6 alkyl, C3-6 cycloalkyl, and (CH2)rphenyl substituted with 0-3 R16e; 
R16d, at each occurrence, is selected from C1-6 alkyl and phenyl; 
R16e, at each occurrence, is selected from C1-6 alkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, OH, and (CH2)rOC1-5 alkyl; and 
R16f, at each occurrence, is selected from H, and C1-5 alkyl.

6. The compound of claim 5, wherein:
Ring B is a 5 or 6 membered saturated heterocycle ring, wherein the heterocycle ring is selected from piperidine, tetrahydropyran, tetrahydrothiopyran, tetrahydrothiopyran 1,1-dioxide, tetrahydrothiopyran 1-monooxide, piperidin-2-one, tetrahydropyran-2-one, [1,2]thiazinane 1,1-dioxide, pyrrolidine, tetrahydrofuran, tetrahydrothiophene, pyrrolidin-2-one, dihydrofuran-2-one, and isothiazolidine 1,1-dioxide, the heterocycle ring being optionally substituted by 0-2 R8; 
R5 is CH2phenyl substituted with 0-3 R16; and 
r is selected from 0, 1, and 2.

7. The compound of claim 6, wherein:
K is selected from CH2 and CHR5; 
L is CHR5; 
R3 is selected from a C3-10 carbocyclic residue substituted with 0-3 R15, wherein the carbocyclic residue is selected from cyclopropyl, cyclopentyl, cyclohexyl, phenyl, naphthyl and adamantyl, and a (CR3′H)rheterocyclic system substituted with 0-3 R15, wherein the heterocyclic system is selected from pyridinyl, thiophenyl, furanyl, indazolyl, benzothiazolyl, benzimidazolyl, benzothiophenyl, benzofuranyl, benzoxazolyl, benzisoxazolyl, quinolinyl, isoquinolinyl, imidazolyl, indazolyl, isoxazolinyl, morpholinyl, pyrrolidinyl, tetrahydropyranyl, tetrahydrofuranyl, indolyl, indolinyl, isoindolyl, isothiadiazolyl, isoxazolyl, piperidinyl, pyrrazolyl, 1,2,4-triazolyl, 1,2,3-triazolyl, tetrazolyl, thiadiazolyl, thiazolyl, oxazolyl, pyrazinyl, and pyrimidinyl; and 
R15, at each occurrence, is selected from C1-8 alkyl, (CH2)rC3-6 cycloalkyl, CF3, Cl, Br, I, F, (CH2)rNR15aR15a′, NO2, CN, OH, (CH2)rOR15d, (CH2)rC(O)R15b, (CH2)rC(O)NR15aR15a′, (CH2)rNR15fC(O)R15b, (CH2)rNR15fC(O)O(CHR′)rR15d, (CH2)rOC(O)NR15aR15a′, (CH2)rS(O)pR15b, (CH2)rS(O)2NR15aR15a′, (CH2)rNR15fS(O)2R15b, (CH2)rphenyl substituted with 0-3 R15e, and a (CH2)r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R15e, wherein the heterocyclic system is selected from tetrazolyl, piperidinyl, pyrrolidinyl, imidazolyl, thiazolyl, pyrazolyl, pyridyl, thienyl, furanyl, pyrrolyl, oxazolyl, isoxazolyl, triazolyl, pyridazinyl, pyrimidinyl, pyrazinyl, morpholinyl, oxadiazolyl, and thiadiazolyl; 
R15a and R15a′, at each occurrence, are selected from H, C1-6 alkyl, C3-6 cycloalkyl, and (CH2)rphenyl substituted with 0-3 R15e; 
alternatively, R15a and R15a′, along with the N to which they are attached, join to form a 5-6 membered heterocyclic system containing 1-2 heteroatoms selected from NR15h, O, and S and optionally fused with a benzene ring or a 6-membered aromatic heterocycle; 
R15b, at each occurrence, is selected from H, C1-6 alkyl, C3-6 cycloalkyl, and (CH2)rphenyl substituted with 0-3 R15e; 
R15d, at each occurrence, is selected from C1-6 alkyl and phenyl; 
R15e, at each occurrence, is selected from C1-6 alkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, OH, and (CH2)rOC1-5 alkyl; and 
R15f, at each occurrence, is selected from H, and C1-5 alkyl.

8. The compound of claim 7, wherein
G is selected from CH2 and C═O; 
L is CHR5; 
B is selected from piperidine, tetrahydropyran, tetrahydrothiopyran, pyrrolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, tetrahydrothiophene 1-oxide, and tetrahydrothiophene 1,1-dioxide; 
R3 is selected from phenyl substituted with 1-2 R15, —CH2—CH2-morpholin-1-yl substituted with 1-2 R15, indazolyl substituted with 1-2 R15, pyrazolyl substituted with 1-2 R15 or thiazolyl substituted with 1-2 R15; 
R5 is selected from a CH2-phenyl substituted with 1-2 R16; 
R9 is selected from H, C2-6 alkyl substituted with 0-3 R9a, wherein the alkyl is selected from methyl, ethyl, propyl, i-propyl, butyl, i-butyl, s-butyl, t-butyl, neo-pentyl; —CH2CH═CH2; 13 CH2C≡CH; 2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, (CH2)rC(O)C1-6 alkyl substituted with 0-2 R9j, wherein the alkyl is selected from methyl, ethyl, propyl, i-propyl, butyl, t-butyl; C(O)Omethyl, C(O)Ot-butyl, SO2methyl, SO2ethyl, SO2propyl, SO2i-propyl, SO2t-butyl, SO2CF3, (CH2)rC(O)NR9dR9d′; (CH2)rC(O)R9′, (CH2)rC(O)NR9dR9′, (CH2)rS(O)2R9′, R9′, and (CH2)rS(O)2NR9dR9′; 
R9′, at each occurrence, is independently selected from (CHR′)rC3-6 cycloalkyl, wherein the cycloalkyl is selected from cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl, (CHR′)rphenyl substituted with 0-3 R9c, (CHR′)r5-6 membered heterocycle system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R9c, wherein the heterocycle is selected from oxadiazolyl, morpholinyl, piperidinyl, tetrahydropyranyl, tetrahydrothiopyranyl, tetrahydrothiopyranyl dioxide, thiophene, imidazolyl, pyrrolidinyl, pyrrolyl, thiazolyl, and furanyl, and (CHR′)rphenyl substituted with 0-3 R9c; 
R9a, at each occurrence, is selected from CN, O-methyl, O-ethyl, CF3, OH, OC(O)-methyl, S-methyl, S-ethyl, S-propyl, S(O)p-methyl, S(O)p-ethyl, S(O)p-propyl, and NR9dR9d′; 
R9c, at each occurrence, is selected from methyl, ethyl, propyl, C(O)-methyl, C(O)O-t-butyl; 
R9d and R9d′, at each occurrence, are independently selected from H, methyl, ethyl, propyl, i-propyl, butyl, t-butyl; 
R9j, at each occurrence, is selected from O-methyl, O-ethyl, and NR9dR9d′; 
R15 is selected from Me, CF3, OMe, OCF3, F, Cl, Br, OH, OMe, C(O)Me, CH(OH)Me, CN, CO2Me, CO2Et, SO2NH2, NHC(O)Me, C(O)NH2, C(O)NHMe, C(O)NHCH2CH2OMe, C(O)piperidinyl, C(O)pyrrolidinyl, C(O)morpholinyl, and a 5-6 membered heterocyclic system, wherein the heterocyclic system is selected from tetrazolyl, indazolyl, pyrazolyl, triazolyl, morpholinyl, and thiazolyl, the heterocyclic system substituted with 0-2 R15e; 
R15e is selected from methyl, ethyl, propyl, i-propyl, cyclopropyl, cyclopropylmethyl, acetyl, and t-butoxycarbonyl; 
R16 is selected from F, Cl, Br, and I.

9. A pharmaceutical composition, comprising a pharmaceutically, acceptable carrier and a therapeutically effective amount of a compound according to claim 1.

10. A method for treating asthma, comprising administering to a patient in need thereof a therapeutically effective amount of a compound according to claim 1.

11. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound according to claim 7, or a pharmaceutically acceptable salt, thereof.

12. A method for treating inflammation in disorders comprising administering to a patient in need thereof a therapeutically effective amount of a compound according to claim 1, or a pharmaceutically acceptable salt thereof, wherein the disorder is selected from asthma, allergic rhinitis, atopic dermatitis, inflammatory bowel diseases, idiopathic pulmonary fibrosis, ulcerative colitis, eczema, transplantation, eosinophilic cellulitis, eosinophilic pneumonias, and eosinophilic fasciitis.

13. The method according to claim 12, wherein the disorder is selected from asthma, allergic rhinitis, atopic dermatitis, and inflammatory bowel diseases.

14. The method according to claim 13, wherein the disorder is asthma.

15. A method for treating inflammation in disorders comprising administering to a patient in need thereof a therapeutically effective amount of a compound according to claim 8, or a pharmaceutically acceptable salt thereof, wherein the disorder is selected from asthma, allergic rhinitis, atopic dermatitis, inflammatory bowel diseases, idiopathic pulmonary fibrosis, ulcerative colitis, eczema, transplantation, eosinophilic cellulitis, eosinophilic pneumonias, and eosinophilic, fasciitis.