### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF CHEMICAL SAFETY AND

POLLUTION PREVENTION



### MEMORANDUM

Date: Apr i l 2, 2013

SUBJECT: Trifluralin: Acu te

, Chronic

, and Cancer Aggregate Dietary (Food and Drinkin g

Water) Exposure and Ri s k Assessme n t s for the Section 3 Re gi s tration Action on

Oil s eed Crop Gro up 20.

PC Code: 036101

Decision No.: 463234

Petition No.: NA DP Barcode: D41 0618

Registration No

. : NA

Regulatory Action: Sectio n 

### 3 Registration

CaseNo.: NA Risk Assessment Typ e: Dietary

TXR No.: NA CAS No .: 158 2

- 09-8

40 CFR: §180.207 MRIDNo.: NA

FROM:

THROUGH :

TO: Sheila Piper,

# emist**~~~** Risk Asses s ment Branch VI

Health Effects Division (7509P)

Julie L. 

### Van Alstine,

# PH,_E**vir~_»e~th****-*i""~****VCVV!..:A-0~** Th ur s ton G. Morton, Che mt st

# /~**q ;;:?'x;Y~~** **-----_** Dietary Expo s ure S c ien ce A d v i sory Counc il ( DES AC)

Feleci:;:rt

, Bra n ch Chi e f

# ~ce~c/-~ Risk Asses s ment Bran ch VI, HED (7509P)

And rew Ertman

, Risk Manager R eviewe r

B a rb ara Madden

, R isk Manager

Registration Division (7505C)

Exec uti ve Summary

Acute

, c hron ic, and cancer aggregate dietary (food and drinkin g water) ex po sure a nd ri sk

a ss e s sment s for the herbicide trifl ura lin were co ndu cted us ing the Dietary Expo s ure Evaluation

Model s oftware wi th the Food Commo d ity Intake Databa s e ( DE EM

- FC ID ) Ver s i on 3.16. T hi s

Page I of27Trinura lin Dietary E xposure and Ri s k A ss e s sment DP Number: 410618



### softwa re uses 2003-2008 food consum ption data from the U.S. Department of Agriculture's

(USDA's) National Hea lth and N utrition Examinat ion Survey, What We Eat in Ame rica,

(NHANESIWWEIA). The analyses were conducted in suppo rt of a human health risk

assessment for th e proposed Section 3 request to add the remaining crops for an Oilseed Crop

Group 20. This memorandum was reviewed by two peer reviewers of the DESAC per the current

DESAC Standard Operating Procedure (SOP).



### Acute Dietary Exposure Assessment

An unrefined, acute dietary exposure assessment using tolerance level s

, default DEEM

processing factors, and assuming 100% crop treated (CT) for the proposed commod itie s was

co ndu cte d for various population subgroups

. . The estimate d drinking water concen trat ion of

trifluralin was provided by the E nvironm e nt al Fate and Effects Division (EFED) and

incorporated directly into the acute assessment. The est imat ed drinking water concentration

(EDWC) for trifluralin and its major d egradate s (TR-4, TR-6 and TR-15) wa s based on the use

of triflura lin on LA s ugarcane. The acute drinking water concentration in s urface water i s 23

. 83

ppb.

There were no appropriate toxicological effect s attributable t o a single expo s ure (dose) for the

genera l population or any ot h er population subgroups excep t females 13-49 years o ld; th erefore,

these population s ub groups were not included in this assessment. For food and drinking water,

th e acute dietary risk estimate i s below HED' s l eve l of co nc ern ( 

### < 100% of the acu t e population

adjus t ed dose (aPAD)) at the 95th percentile of exposure. The acute dietary exposure estimate for

females 13 -49 year s old i s l ess than 1% of the aPAD.



### Ch ronic Dietary Exposure Assess ment

The chronic d ietary expo s ure and ri sk estimate s are somewhat refined s ince they assume

tolerance le ve l s, %CT data, an d DE EM default processing factors. Pe s ticide Data Program

(P DP) monitoring data were used fo r carrot, orange, orange ju ice, pepper, potato, and tomato

which had a signif i cant impact on the cancer exposure. The chronic EDWC in s urfac e water for

trifl uralin i s 1.97 ppb.

Combined chronic dietary exposure estimate s for food a nd drinking wa t er are we ll below HED 's

level o f concern. U s ing the DEE M-FC ID s oftware

, dietary expo s ure i s le ss than 1 % for the U.S.

population and all in fant s the most highly expo s ed population subgro up

.



### Cancer Dietary Exposure Asses sment

The Agency cla ssified triflura lin as a Group C

- "poss ible" human carcinogen. The 

## Q

1 

### *is 2.96 X

10· 3 

### (mglkg/day) : 1 

### The cancer chronic EDWC in s urface wate r for trifluralin is 1.59 ppb. For

food and drinking water, the cancer dietary expo s ure estimate for the U.S. population is 2.1 xl0

- 7



### I. Int roducti on

Pa g e 2 o f27Trifluralin Dietary Exposure and Risk Assessment DP Number: 4 10618

Page 3 of 27 

### I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose

(i.e., the dose that HED has concluded will result in no unreasonab le adverse health effects).

This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to the

point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety

factors.

For acute and non

- cancer chronic exposures, HED is concerned when estimated dietary risk

exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in

more detail are available on the EPA/pesticides web site: “Available Information on Assessing

Exposure fro m Pesticides, A User’s Guide,” 21

- JUN

- 2000, web link:

http://www.epa.gov/fedrgstr/EPA

- PEST/2000/July/Day

- 12/6061.pdf ; or see SOP 99.6 (20

- AUG

1999).

The most recent dietary risk assessment for trifluralin was conducted by S. Piper ( 08/10/2004

, D 296628 ).

II. Residue Information

Trifluralin is a selective, pre

- emergence, dinitroaniline herbicide registered for the control of

annual grasses and certain broadleaf weeds. Tolerances for residues of trifluralin (α,α, α

trifluoro

- 2,6

- dinitro

- N. N

- dipropyl

- p

- toluidine) in/o n plant and processed commodities are

currently expressed in terms of the residues of trifluralin . Permanent tolerances are established

for plant commodities under 40 CFR §180. 207 and tolerances range from 0.05 ppm to 2.0 ppm

.

The residue of concern for both the tolerance expression and risk assessment in plants is

trifluralin

. No livestock tolerances have been established.

IR

- 4 is requesting permanent tolerances for trifluralin use on Oilseed CG 20. Tolerances at 0.05

ppm for canola/rapeseed, seeds of flax, mustard, sunflower, safflower, and cottonseed have

already been established. The proposed use pattern for all members of the rapeseed subgroup

20A, sunflower subgroup 20B, and cottonseed subgroup 20C, ha s the same use p attern ;

therefore, HED is recommending a tolerance of 0.05 ppm for CG 20

.

Residue Data used for the Acute Dietary Assessment:

An unrefined, acute dietary exposure assessment using tolerance levels, default DEEM

proc essing factors (except for orange juice and tomato paste used PDP data) , and assuming

100 % CT for the proposed commodities.Trifluralin Dietary Exposure and Risk Assessment DP Number: 4 10618

Page 4 of 27 

### Residue Data used for the Chronic and Cancer Dietary Assessment:

The chronic dietary exposure and risk estimates are somewhat refined since they assume

tolerance levels, %CT , and DEEM default processing factors. PDP monitoring data were used

for carrot, orange, orange juice, pepper, potato, and tomato which had a significant impact on the

cancer exposure. See table 1 below for calculations.

Table 1 : Trifluralin Summary of Data and Residue Estimates Used for Chronic Dietary E xposure

Analysis

Commodity Data Source No. of

Samples No. of

Detects 1⁄2 LOD

(ppm) % Crop

Treated

(avg.) Anticipated

Residues

(Chronic /Cancer )

Carrots PDP data

2006

- 07 1487 796 0.0085 40 0.0 22

Orange PDP data

2009

- 10 1488 0 0.015 1 0.015

Orange Juice PDP data

2010 191 0 0.0005 1 0.0005

Pepper PDP 2010 277 0 0.001 25 0.001

Potato PDP data

2009

- 08 1488 4 0.0085 2.5 0.009

Tomato PDP data

2008

- 07 1481 0 0.0 1 60 0.01

Tomato Paste PDP data

2010 742 0 0.0 475 6 0 0.0 475



### I I I. Percent Crop Treated Information

The Biological and Economic Analysis Division (BEAD) has provided an updated Screening

Level Usage Analysis (SLUA) for trifluralin (D 406856

, J. Alsadek

, 12/12/2012 ) which includes

both an average and maximum P CT for the established uses.

For the acute d ietary exposure assessment, 100 %CT was assumed for all commodities. The

following average percent crop treated estimates were used in the chronic and cancer dietary risk

assessments for the following crops that are currently registered for trifluralin : a lmonds : 1 %;

asparagus: 2 0%; barley: 1 %; g reen bean : 2 5%; broccoli : 10%; cabbage: 40% ; canola : 2.5 %;

c a ntaloupe : 25 %; c a rrot: 40 %; cauliflower : 10%; celery: 12.5%; corn: 1% ; cotton : 30%;

cucumber: 2.5 %; dry bean /pea : 1 0%; garlic: 5%; grapefruit: 1 %; grape : 2.5% ; honeydew : 20 %;

l emon : 1%; onion : 2 .5 %; orange : 1 %; peac h : 1 %; p eanut : 5% ; pecan : 1 %; p epper : 25%;

pistachio : 2.5 %; p otato : 2. 5%; pumpkin: 5 %; sorghum: 1 % ; soybean : 5 %; squash : 5 %;Trifluralin Dietary Exposure and Risk Assessment DP Number: 4 10618

Page 5 of 27 

### sugarbeet: 2.5%; sugarcane: 5%; sunflower : 10 %; tomato : 60 % ; walnut : 1%; watermelon : 10%;

and wheat: 1 %. See Attachment 7

.

IV. Drinking Water Data

References: Drinking Water Assessment to Establish Tolerances of Parent Trifluralin and its

Degradates for Oilseed Crop Group 20, D 401006

, Faruque Khan

, 07 / 02 /2012.

A screening level drinking water assessment was conducted to support the human health risk

assessment to expand canola/rapeseed, sunflower seed and cottonseed tolerance s of trifluralin

herbicide to include oilseed CG 20. This is an abbreviated drinking water assessment to provide

EDWC of trifluralin and its major degradates in surface water and ground water in support of

human health risk assessment. The assessment is based on drinking water assessment previously

performed for the Tolerance Reassessment Eligibility Decision (TRED) (D296624, December 3,

2003). The EDWCs for oilseed crops are based on the maximum proposed application rates for

aerial and ground applications specified in the proposed product labels (Treflan ® 

### HFP, an d

Treflan ® 

### TR

- 10)

. Water residues were incorporated in the DEEM

- FCID into the food categories

“water, direct, all sources” and “water, indirect, all sources .”

T he EECs for trifluralin and its major degradates TR

- 4 ( α

, α

, α

- trifluoro

- 5

- nitro

- N4,N4

- dipropyl

toluene

- 3,4

- diamine) , TR

- 6 ( 5

- trifluoromethyl

- 3

- nitro

- 1,2

- benzenediamine) and TR

- 15 ( 2

- ethyl

7

- nitro

- 5

- (trifluoromethyl) benzimidazole) are the residues of concern in drinking water. The

EDWCs of total toxic trifluralin residue for various crops were gene rated with the coupled

models PRZM and EXAMS for surface water and SCI

- GROW for ground water. The upper

bound EDWCs for trifluralin and its major degradates are provided in Table 2 for the human

health risk assessment.

The most conservative estimates were obtained from aerial application of trifluralin to LA

s ugarcane as a surrogate scenario for Hawaii at the maximum labeled annual application rate of 4

lbs a.i./acre, applied twice annually at 2 lbs a.i./acre. The update d EDWCs for sugarcane are

lower than the previously reported EDWCs in the TRED (U.S. EPA 2003) due to two

applications at 2.0 lbs a.i./A as prescribed in current labels instead of 1 application at 4.0 lbs/A

per year used in the previous assessment. Based on the results of current modeling , EFED

recommends an acute EDWC of 23.83 μg/L

, a chronic EDWC of 1.97 μg/L

, and a cancer chronic

EDWC of 1. 59 μg/L for surface water be use d in the human health risk assessment. The model

and its description are available at the EPA internet site:

http://www.epa.gov/oppefed1/models/water/

.

Table 2 . Estimated Drinking Water Concentrations (EDWCs) of Trifluralin and its

Degradates for Surface Water using PRZM/EXAMS and Groundwater using SCIGROW

Drinking Water

Source (model) Use

Scenario

(modeled rate) 1

- in

- 10 year acute

( 

### μg/L ) 1

- in

- 10 year chronic

( 

### μg/L ) 30

- year average

( 

### μg/L )

Surface Water

(PRZM/EXAMS) Sugarcane :

FL Sugarcane STD

( 2 app. X 1.0 lbs ai/acre ) 3.89 (A) 1 0.74(A) 0.59(A)Trifluralin Dietary Exposure and Risk Assessment DP Number: 4 10618

Page 6 of 27 

### Table 2 . Estimated Drinking Water Concentrations (EDWCs) of Trifluralin and its

Degradates for Surface Water using PRZM/EXAMS and Groundwater using SCIGROW

Drinking Water

Source (model) Use

Scenario

(modeled rate) 1

- in

- 10 year acute

( 

### μg/L ) 1

- in

- 10 year chronic

( 

### μg/L ) 30

- year average

( 

### μg/L )

Sugarcane :

LA Sugarcane STD ( 2 app.

X 1.0 lbs ai/acre )

LA Sugercane STD 2 app.

X 2.0 lbs ai/acre ) 2 11.92(A)

23.83 (A) 3

19.37 (G) 4 0.99(A)

1.97(A) 3

1.76 (G) 4 0.80(A)

1.59(A) 3

1.35 (G) 4

Oilseed:

CA Cotton STD

1 app. X 2.0 lbs ai/acre ) 3 12.82 (A) 0.35 (A) 0.33 (A)

Oilseed:

MS Cotton STD

1 app. X 2.0 lbs ai/acre ) 3 21.35 (A) 1.08 (A) 0.84 (A)

Oilseed:

NC Cotton STD

1 app. X 2.0 lbs ai/acre ) 3 19.63 (A) 0.99 (A) 0.88 (A)

Oilseed:

ND Canola STD

1 app. X 1.25 lbs ai/acre ) 3 8.16 (A) 0.30 (A) 0.25 (A)

Groundwater

(SCI

- GROW) For sugarcane

( 2 app. X 2.0 lbs a

. i

. /acre)

Cottonseed

1 app. X 2.0 lbs/Acre

Oil Seed

1 app. X 1.25 lbs a.i./acre 2.75E

- 02 5

1.37E

- 02

8.58 E

- 03 2.75

- 02 5

1.37E

- 02

8.58 E

- 03 2.75E

- 02 5

1.37E

- 02

8.58 E

- 03

1

= Aerial application

2 = LA Sugarcane STD scenario was used as a surrogate scenario to calculate EDWCs for trifluralin uses in Hawaii

3 = Bolded EDWCs are recommended exposure values for surface water sources for human health risk assessment

4

= Ground application. Exposure from ground application of trifluralin is compared with aerial application for the

highest exposure scenario ( LA S ugarcane STD ) for sugarcane at 4.0.lbs/a.i./A.

5 = Groundwater EDWC can be used for acute, chronic and cancer chronic concerns



### V. DEEM

- FCID Program and Consumption Information

Trifluralin acute, chronic

, and cancer dietary exposure assessments were conducted using the

DEEM

- FCID, Version 3.16 , which incorporates 2003

- 2008 consumption data from USDA’s

NHANES/WWEIA. The data are based on the reported consumption of more than 20,000

individuals over two non

- consecutive survey days. Foods “as consumed” (e.g., apple pie) are

linked to EPA

- defined food commodities (e.g.

, apples, peeled fruit

- cooked; fresh or N/S; baked;

or wheat flour

- cooked; fresh or N/S, baked) using publicly available recipe translation files

develo ped jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data

are averaged for the entire U.S. population and within population subgroups . However , for acute

exposure assessment

, consumption data are retained as individual consumptio n events. Based on

analysis of the 2003

- 2008 WWEIA consumption data, which took into account dietary patternsTrifluralin Dietary Exposure and Risk Assessment DP Number: 4 10618

Page 7 of 27 

### and survey respondents, HED concluded that it is most appropriate to report risk for the

following population subgroups: the general U.S. populat ion, all infants (<1 year old), children

1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19, adults 20

- 49, females 13

- 49, and adults 50

- 99

years old.

For a chronic dietary exposure assessment, an estimate of the residue level in each food or food

form (e.g., o range or orange juice) on the food commodity residue list is multiplied by the

average daily consumption estimate for that food/food form to produce a residue intake estimate.

The resulting residue intake estimate for each food/food form is summed with th e residue intake

estimates for all other food/food forms on the commodity residue list to arrive at the total

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent

of the cPAD. This procedure is performed for each po pulation subgroup.

For an acute exposure assessment, individual one

- day food consumption data are used on an

individual

- by

- individual basis. The reported consumption amounts of each food item can be

multiplied by a residue point estimate and summed to ob tain a total daily pesticide exposure for a

deterministic exposure assessment, or “matched” in multiple random pairings with residue values

and then summed in a probabilistic assessment. The resulting distribution of exposures is

expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating

relevant commodities/food forms) and a per

- capita (i.e., those who reported eating the relevant

commodities as well as those who did not) basis. In accordance with HED policy, per capita

ex posure and risk are reported for a nalyses performed at all levels of refinement . However, for

deterministic assessments , any significant differences in user vs. per capita exposure and risk are

specifically identified and noted in the risk assessment.

V I. Toxicological Information

HED evaluated the toxicology database for trifluralin and selected the following doses and

endpoints for the dietary risk assessment (Hazard Identification Assessment Review Committee

04/17/2003). The Q 1 * 

### of 5.79 X 10

- 3 

### (mg/ kg/day)

- 1 

### was updated to 2.96 x 10

- 3 

### (mg/kg/day)

- 1 

### in

2004 based on the Fischer 344 Rat Dietary 3⁄4’s scaling factor (May 11, 2004, TXR No.

0052534) and is still based on the incidence of male rat thyroid follicular cell combined

adenoma, papillary adenoma, cystadenoma, and carcinoma tumors. It has been classified as a

Group C (“Possible” Human Carcinogen). Table 3 provides a summary of the toxicological

doses and endpoints for trifluralin for use in the dietary exposure assessment.

Table 3 : Summary of Toxicological Points of Departure and En dpoints for Trifluralin for Use in

Dietary Human Health Risk Assessments

Exposure/

Scenario Point of

Departure Uncertainty

Factors Level of Concern for

Risk Assessment Study and Toxicological Effects

Acute Dietary

(Females 13

- 50

years of age) NOAEL = 100

mg/kg/day UF A =10x

UF H =10x

FQPA SF

=1 100 mg/kg/day NOAEL

100 (UF)

aRfD = 1.0 mg/kg/day Developmental Toxicity Study

– Rat

LOAEL = 500 mg/kg/day, based

on increased total litter

resorptionsTrifluralin Dietary Exposure and Risk Assessment DP Number: 4 10618

Page 8 of 27 

### Table 3 : Summary of Toxicological Points of Departure and En dpoints for Trifluralin for Use in

Dietary Human Health Risk Assessments

Acute Dietary

(General

population,

including infants

and children) No endpoints identified from the available developments toxicity studies (rat and rabbit) appropriate for

an acute dietary assessment for trifluralin.

Chronic Dietary

(All populations) NOAEL =

2.4 mg/kg/day UF A =10x

UF H =10x

FQPA SF

=1 2 .4mg/kg/day NOAEL

100 (UF)

cRfD = 0.024 mg/kg/day Chronic (capsule) Toxicity

– Dog

LOAEL = 40 mg/kg/day, based on

increased frequency of abnormal

stool, decreased body weights and

body weight gains, and decreased

erythrocytes and hemoglobin and

increased thrombocytes (males)

Cancer (oral,

dermal, inhalation) Classification: Group C (“Possible” Human Carcinogen)

Q 1 * = 2.96 X 10

- 3 (mg/kg/day)

- 1 (TXR No. 00052534)

1 Explanation of Abbreviations: Point of Departure (PoD) = A data point or an estimated point that is

derived from observed dose

- response data and used to mark the beginning of extrapolation to determine

risk associated with lower environmentally relevant human exposures. NOAEL = no observed adverse

effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A = extrapolation

from anima l to human (interspecies). UF A = extrapolation from animal to human (interspecies). UF H = potential variation in sensitivity among members of the human population (intraspecies). UF DB = database

uncertainty, lack of neurotoxicity (acute and subchronic) and immunotoxicity studies,



### VII. Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds

100% of the PAD. The DEEM

- FCID analyses estimate the dietary exposure of the U.S.

population and variou s population subgroups. The results reported in Table 4 are for the general

U.S. Population, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19,

females 13

- 49, adults 20

- 49, and adults 50

- 99 years. Cancer risk is determined for the general

U.S. population only.

Acute Dietary Exposure A nalysis

There were no appropriate toxicological effects attributable to a single exposure (dose) for the

general population or any other population subgroups except females 13

- 49 years old ; t herefore

, these population subgroups were not included in this assessment. For food and drinking water,

the acute dietary risk estimate is below HED’s level of concern (<100% of the aPAD ) at the 95 th



### percentile of exposure. The acute dietary exposure estimate for females 13

- 49 years old is less

than 1 % of the aPAD

.Trifluralin Dietary Exposure and Risk Assessment DP Number: 4 10618

Page 9 of 27 

### Chronic Dietary Exposure A nalysis

C ombined chronic dietary exposure estimates for food and drinking water are well below HED’s

level of concern. Using the DEEM

- FCI D software, dietary exposure is less than 1% for the U.S.

population and all infants

, the most highly exposed population subgroup.

Cancer Dietary Exposure A nalysis

The Agency classified trifluralin as a Group C

- “possible” human carcinogen. The Q 1 * 

### is 2.96 X

10

- 3 

### (mg/kg/day)

. - 1 

### The cancer chronic EDWC in surface water for trifluralin is 1. 59 ppb. For

food and drinking water, the cancer dietary exposure estimate for the U.S. population is 2.1 x10

-

7



### .

Table 4 . Summary of Dietary (Food and Drinking Water ) Exposure and Risk for Trifluralin

Population Subgroup Acute Dietary

(95 th 

### Percentile) Chronic Dietary Cancer

Dietary

Exposure

(mg/kg/day) %

aPAD Dietary

Exposure

(mg/kg/day) %

cPAD Dietary

Exposure

(mg/kg/day) Risk

General U.S. Population

N/A 0.0000 78 <1 0.000070 2.1 E

- 07

All Infants (<1 year old) 0.0002 13 <1

N/A N/A Children 1

- 2 years old 0.000 158 <1

Children 3

- 5 years old 0.0001 28 <1

Children 6

- 12 years old 0.000 082 <1

Youth 13

- 19 years old 0.0000 55 <1

Adults 20

- 49 years old 0.0000 70 <1

Adults 50

- 99 years old 0.0000 74 <1

Females 13

- 49 years old 0.002 305 <1 0.0000 70 <1



### VIII. Characterization of Inputs/Outputs

The assumptions made in this acute assessment are conservative; tolerance level residues and

assuming 100% crop treated. For chronic and cancer assessment s

, monitoring data (PDP) and

percent crop treated were used for carrots, orange, orange juice, pepper, potato, and tomato since

they had a significant impact on exposure . More highly refined analyses are not needed at this

time since the risk estimates are below HED’s level of concern.

IX. Conclusions

This somewhat refine analysis demonstrates that the requested uses for trifluralin will not result

in an acute

, chronic and cancer dietary risk estimates that exceed HED’s level of concern for any

of the regulated populated subgroups, including those comprised of infants and children.Trifluralin Dietary Exposure and Risk Assessment DP Number: 4 10618

Page 10 of 27 

### X. List of Attachments

Attachment 1: Acute Food plus Water Residue Input File

Attachment 2: Acute Results File

Attachment 3: Chronic Food plus Water Residue Input File

Attachment 4: Chronic Results File

Attachment 5: Cancer Food plus Water Residue Input File

Attachment 6: Cancer Results File

Attachment 7 : Trifluralin Screening Level Usage Analysis ( SLUA )

Attachment 1: Acute Food plus Water Residue Input File

Filename: C: \ Documents and

Settings \ spiper \ Desktop \ Trifluralin \ Dietary \ Trifluralin_acute_tolerance.r08

Chemical: Trifluralin

RfD(Chronic): .024 mg/kg bw/day NOEL(Chronic): 2.4 mg/kg bw/day

RfD(Acute): 1 mg/kg bw/day NOEL(Acute): 100 mg/kg bw/day Q*= .0058

Date created/last modified: 01

- 31

- 2013/11:52:33 Program ver. 3.16, 03

- 08

- d

Comment: Females 13

- 50 yrs only (acute)

- ---------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment

Code Grp Commodity Name (ppm) #1 #2

---------- --- - ------------------------------- ---------- ------ ------ ------- 9500019000 O Asparagus 0.050000 1.000 1.000

9500177000 O Grape, leaves 0.050000 1.000 1.000

9500178000 O Grape, raisin 0.050000 4.300 1.000

9500188000 O Hop 0.050000 1.000 1.000

9500263000 O Peanut 0.050000 1.000 1.000

9500264000 O Peanut, butter 0.0500 00 1.890 1.000

9500265000 O Peanut, oil 0.050000 1.000 1.000

9500275000 O Peppermint 0.050000 1.000 1.000

9500276000 O Peppermint, oil 2.000000 1.000 1.000

9500352000 O Spearmint 0.050000 1.000 1.000

9500353000 O Spearmint, oil 2.000000 1.000 1.000

9500363000 O Sugarcane, molasses 0.050000 1.000 1.000

9500363001 O Sugarcane , molasses

- babyfood 0.050000 1.000 1.000

9500362000 O Sugarcane, sugar 0.050000 1.000 1.000

9500362001 O Sugarcane, sugar

- babyfood 0.050000 1.000 1.000

0103015000 1CD Arrowroot, flour 0.050000 1.000 1.000

0103015001 1CD Arrowroot, flour

- babyfood 0.050000 1.000 1.000

0103017000 1CD Artichoke, Jerusalem 0.050000 1.000 1.000

0101050000 1AB Beet, garden, roots 0.050000 1.000 1.000

0101050001 1AB Beet, garden, roots

- babyfood 0.050000 1.000 1.000

0101052000 1A Beet, sugar 0.050000 1.000 1.000

0101053000 1A Beet, sugar, molasses 0.050000 1.000 1.000

0101053001 1A Beet, s ugar, molasses

- babyfood 0.050000 1.000 1.000

0101052001 1A Beet, sugar

- babyfood 0.050000 1.000 1.000

0101067000 1AB Burdock 0.050000 1.000 1.000

0101078000 1AB Carrot 1.000000 1.000 1.000

0101079000 1AB Carrot, juice 1.000000 1.000 1.000

0101078001 1AB Carrot

- babyfood 1.000000 1.000 1.000

0103082000 1CD Cassava 0.050000 1.000 1.00 0

0103082001 1CD Cassava

- babyfood 0.050000 1.000 1.000

0101084000 1AB Celeriac 0.050000 1.000 1.000

0101100000 1AB Chicory, roots 0.050000 1.000 1.000

0103139000 1CD Dashe en, corm 0.050000 1.000 1.000

0103166000 1CD Ginger 0.050000 1.000 1.000

0103167000 1CD Ginger, dried 0.050000 1.000 1.000Trifluralin Dietary Exposure and Risk Assessment DP Number: 4 10618

Page 11 of 27 0103166001 1CD Ginger

- babyfood 0.050000 1.000 1.000

0101168000 1AB Ginseng, dried 0.050000 1.000 1.000

0101190000 1AB Horseradish 0.050000 1.000 1.000

0101250000 1AB Parsley, turnip rooted 0.050000 1.000 1.000

0101251000 1AB Parsnip 0.050000 1.000 1.000

0101251001 1AB Parsnip

- babyfood 0.050000 1.000 1.000

0103296000 1C Potato, c hips 0.050000 1.000 1.000

0103297000 1C Potato, dry (granules/ flakes) 0.050000 6.500 1.000

0103297001 1C Potato, dry (granules/ flakes)

- b 0.050000 6.500 1.000

0103298000 1C Potato, flour 0.050000 1.000 1.000

0103298001 1C Potato, flour

- babyfood 0.050000 1.000 1.000

0103300000 1C Potato, tuber, w/o peel 0.050000 1.000 1.000

0103300001 1C Potato, tuber, w/o peel

- babyfood 0.050000 1.000 1.000

0103299000 1C Potato, tuber, w/peel 0.050000 1.000 1.000

0103299001 1C Potato, tuber, w/peel

- babyfood 0.050000 1.000 1.000

0101316000 1AB Radish, Oriental, roots 0.050000 1.000 1.000

0101314000 1AB Radish, roots 0.050000 1.000 1.000

0101327000 1AB Rutabaga 0.050000 1.000 1.000

0101331000 1AB Salsify, roots 0.050000 1.000 1.000

0103366000 1CD Sweet potato 0.050000 1.000 1.000

0103366001 1CD Sweet potato

- babyfood 0.050000 1.000 1.000

0103371000 1CD Tanier, corm 0.050000 1.000 1.000

0103387000 1CD Turmeric 0.050000 1.000 1.00 0

0101388000 1AB Turnip, roots 0.050000 1.000 1.000

0103407000 1CD Yam bean 0.050000 1.000 1.000

0103406000 1CD Yam, true 0.050000 1.000 1.000

0200051000 2 Beet, garden, tops 0.050000 1.000 1.000

0200101000 2 Chicory, tops 0.050000 1.000 1.000

0200140000 2 Dasheen, leaves 0.050000 1.000 1.000

0200317000 2 Radish, Oriental, tops 0.050000 1.000 1.000

0200315000 2 Radish, tops 0.050000 1.000 1.000

0200332000 2 Salsify, tops 0.050000 1.000 1.000

0302103000 3B Chive, fr esh leaves 0.050000 1.000 1.000

0301165000 3A Garlic, bulb 0.050000 1.000 1.000

0301165001 3A Garlic, bulb

- babyfood 0.050000 1.000 1.000

0302198000 3B Leek 0.050000 1.000 1.000

0301237000 3A Onion, bulb 0.050000 1.000 1.000

0301238000 3A Onion, bulb, dried 0.050000 9.000 1.000

0301238001 3A Onion, bulb, dried

- babyfood 0.050000 9.000 1.000

0301237001 3A Onion, bulb

- babyfood 0.050000 1.000 1.000

0302239000 3B Onion, green 0.050000 1.000 1.000

0301338000 3A Shallot, bulb 0.050000 1.000 1.000

0302338500 3B Shallot , fresh leaves 0.050000 1.000 1.000

0402085000 4B Celery 0.050000 1.000 1.000

0402086000 4B Celery, juice 0.050000 1.000 1.000

0402085001 4B Celery

- babyfood 0.050000 1.000 1.000

0401150000 4A Endive 0.050000 1.000 1.000

0501061000 5A Broccoli 0.050000 1.000 1.000

0502063000 5B Broccoli raab 0.050000 1.000 1.00 0

0501062000 5A Broccoli, Chinese 0.050000 1.000 1.000

0501061001 5A Broccoli

- babyfood 0.050000 1.000 1.000

0501064000 5A Brussels sprouts 0.050000 1.000 1.000

0501069000 5A Cabba ge 0.050000 1.000 1.000

0502070000 5B Cabbage, Chinese, bok choy 0.050000 1.000 1.000

0501072000 5A Cabbage, Chinese, mustard 0.050000 1.000 1.000

0501071000 5A Cabbage, Chinese, napa 0.050000 1.000 1.000

0501083000 5A Cauliflower 0.050000 1.000 1.000

0502117000 5B Collards 0.050000 1.000 1.000

0502194000 5B Kale 0.050000 1.000 1.000

0501196000 5A Kohlrabi 0.050000 1.000 1.000

0502229000 5B Mustard greens 0.050000 1.000 1.000

0502318000 5B Rape gree ns 0.050000 1.000 1.000

0502389000 5B Turnip, greens 0.050000 1.000 1.000

0603035000 6C Bean, great northern, seed 0.050000 1.000 1.000

0603030000 6C Bean, black, seed 0.050000 1.000 1.000

0603032000 6C Bean, broad, seed 0.050000 1.000 1.000Trifluralin Dietary Exposure and Risk Assessment DP Number: 4 10618

Page 12 of 27 0602031000 6B Bean, broad, succulent 0.050000 1.000 1.000

0603034000 6C Bean, cowpea, seed 0.050000 1.000 1.000

0602033000 6B Bean, cowpea, succulent 0.050000 1.000 1.000

0603036000 6C Bean, kidney, seed 0.050000 1.000 1.000

0603038000 6C Bean, lima, seed 0.050000 1.000 1.000

0602037000 6B Bean, l ima, succulent 0.050000 1.000 1.000

0603039000 6C Bean, mung, seed 0.050000 1.000 1.000

0603040000 6C Bean, navy, seed 0.050000 1.000 1.000

0603041000 6C Bean, pink, seed 0.050000 1.000 1.000

0603042000 6C Bean, pinto, seed 0.050000 1.000 1.000

0601043000 6A Bean, snap, succulent 0.050000 1.000 1.000

0601043001 6A Bean, snap, succulent

- babyfood 0.050000 1.000 1.00 0

0603099000 6C Chickpea, flour 0.050000 1.000 1.000

0603098000 6C Chickpea, seed 0.050000 1.000 1.000

0603098001 6C Chickpea, seed

- babyfood 0.050000 1.000 1.000

0603182000 6C Guar, seed 0.050000 1.000 1.000

0603182001 6C Guar, seed

- babyfood 0.050000 1.000 1.000

0603203000 6C Lentil, seed 0.050000 1.000 1.000

0603256000 6C Pea, dry 0.050000 1.000 1.000

0603256001 6C Pea, dry

- babyfood 0.050000 1.000 1.000

0601257000 6A Pea, edible podded, succulent 0.050000 1.000 1.000

0603258000 6C Pea, pigeon, seed 0.050000 1.000 1.000

0602259000 6B Pea, pigeon, succulent 0.050000 1.000 1.000

0602255000 6B Pea, succulent 0.050000 1.000 1.000

0602255001 6B Pea, succ ulent

- babyfood 0.050000 1.000 1.000

0603348000 6C Soybean, flour 0.050000 1.000 1.000

0603348001 6C Soybean, flour

- babyfood 0.050000 1.000 1.000

0600350000 6 Soybean, oil 0.050000 1.000 1.000

0600350001 6 Soybean, oil

- babyfood 0.050000 1.000 1.000

0600347000 6 Soybean, seed 0.050000 1.000 1.000

0600349000 6 Soybean, soy milk 0.050000 1.000 1.000

0600349001 6 Soybean, soy milk

- babyfood or in 0.050000 1.000 1.000

0601349500 6AB Soybean, vegetable 0.050000 1.000 1.000

0802148000 8BC Eggplant 0.050000 1.000 1.000

0802234000 8BC Okra 0.050000 1.000 1.000

0802270000 8B Pepper, bell 0.050000 1.000 1.000

0802271000 8B Pepper, bell, dried 0.050000 1.000 1.000

0802271001 8B Pepper, bell, dried

- babyfood 0.050000 1.000 1.000

0802270001 8B Pepper, bell

- babyfood 0.050000 1.000 1.000

0802272000 8BC Pepper, nonbell 0.050000 1.000 1.000

0802273000 8BC Pepper, nonbell, dried 0.050000 1.000 1.00 0

0802272001 8BC Pepper, nonbell

- babyfood 0.050000 1.000 1.000

0801374000 8A Tomatillo 0.050000 1.000 1.000

0801375000 8A Tomato 0.050000 1.000 1.000

0801380000 8A Tomat o, Tree 0.050000 1.000 1.000

0801378000 8A Tomato, dried 0.050000 14.300 1.000

0801378001 8A Tomato, dried

- babyfood 0.050000 14.300 1.000

0801379000 8A Tomato, juice 0.050000 1.500 1.000

0801376000 8A Tomato, paste 0.050000 5.400 1.000

0801376001 8A Tomato, paste

- babyfood 0.050000 5.400 1.000

0801377000 8A Tomato, p uree 0.050000 3.300 1.000

0801377001 8A Tomato, puree

- babyfood 0.050000 3.300 1.000

0801375001 8A Tomato

- babyfood 0.050000 1.000 1.000

0902021000 9B Balsam pear 0.050000 1.000 1.000

0901075000 9A Cantaloupe 0.050000 1.000 1.000

0902088000 9B Chayote, fruit 0.050000 1.000 1.000

0902102000 9B Chinese waxgourd 0.050000 1.000 1.000

0902135000 9B Cucumber 0.050000 1.000 1.000

0901187000 9A Honeydew melon 0.050000 1.000 1.000

0902308000 9B Pumpkin 0.050000 1.000 1.000

0902309000 9B Pumpkin , seed 0.050000 1.000 1.000

0902356000 9B Squash, summer 0.050000 1.000 1.000

0902356001 9B Squash, summer

- babyfood 0.050000 1.000 1.000

0902357000 9B Squash, winter 0.050000 1.000 1.000

0902357001 9B Squash, winter

- babyfood 0.050000 1.000 1.000

0901399000 9A Watermelon 0.050000 1.000 1.000Trifluralin Dietary Exposure and Risk Assessment DP Number: 4 10618

Page 13 of 27 0901400000 9A Watermelon, juice 0.050000 1.000 1.00 0

1001106000 10A Citron 0.050000 1.000 1.000

1001107000 10A Citrus hybrids 0.050000 1.000 1.000

1001108000 10A Citrus, oil 0.050000 1.000 1.000

1003180000 10C Grape fruit 0.050000 1.000 1.000

1003181000 10C Grapefruit, juice 0.050000 2.100 1.000

1002197000 10B Kumquat 0.050000 1.000 1.000

1002199000 10B Lemon 0.050000 1.000 1.000

1002200000 10B Lemon, juice 0.050000 2.000 1.000

1002200001 10B Lemon, juice

- babyfood 0.050000 2.000 1.000

1002201000 10B Lemon, peel 0.050000 1.000 1.000

1002206000 10B Lime 0.050000 1.000 1.000

1002207000 10B Lime, juice 0.050000 2.000 1.000

1002207001 10B Lime, jui ce

- babyfood 0.050000 2.000 1.000

1001240000 10A Orange 0.050000 1.000 1.000

1001241000 10A Orange, juice 0.050000 1.800 1.000

1001241001 10A Orange, juice

- babyfood 0.050000 1.800 1.000

1001242000 10A Orange, peel 0.050000 1.000 1.000

1003307000 10C Pummelo 0.050000 1.000 1.000

1001369000 10A Tangerine 0.050000 1.000 1.000

1001370000 10A Tangerine, juice 0.050000 2.300 1.000

1202012000 12B Apricot 0.050000 1.000 1.000

1202013000 12B Apricot, dried 0.050000 6.000 1.000

1202014000 12B Apricot , juice 0.050000 1.000 1.000

1202014001 12B Apricot, juice

- babyfood 0.050000 1.000 1.000

1202012001 12B Apricot

- babyfood 0.050000 1.000 1.000

1201090000 12A Cherry 0.050000 1.000 1.000

1201091000 12A Cherry, juice 0.050000 1.500 1.000

1201091001 12A Cherry, juice

- babyfood 0.050000 1.500 1.000

1201090001 12A Cherry

- babyfood 0.050000 1.000 1.00 0

1202230000 12B Nectarine 0.050000 1.000 1.000

1202260000 12B Peach 0.050000 1.000 1.000

1202261000 12B Peach, dried 0.050000 7.000 1.000

1202261001 12B Peach , dried

- babyfood 0.050000 7.000 1.000

1202262000 12B Peach, juice 0.050000 1.000 1.000

1202262001 12B Peach, juice

- babyfood 0.050000 1.000 1.000

1202260001 12B Peach

- babyfood 0.050000 1.000 1.000

1203285000 12C Plum 0.050000 1.000 1.000

1203287000 12C Plum, prune, dried 0.050000 5.000 1.000

1203287001 12C Plum, prune, dried

- babyfood 0.050000 5.000 1.000

1203286000 12C Plum, prune, fresh 0.050000 1.000 1.000

1203286001 12C Plum, prune, fresh

- babyfood 0.050000 1.000 1.000

1203288000 12C Plum, pru ne, juice 0.050000 1.400 1.000

1203288001 12C Plum, prune, juice

- babyfood 0.050000 1.400 1.000

1203285001 12C Plum

- babyfood 0.050000 1.000 1.000

1304175000 13D Grape 0.050000 1.000 1.000

1304176000 13D Grape, juice 0.050000 2.100 1.000

1304176001 13D Grape, juice

- babyfood 0.050000 2.100 1.000

1304179000 13D Grape, wine and sherry 0.050000 1.000 1.000

1400003000 14 Almond 0.050000 1.000 1.000

1400004000 14 Almond, oil 0.050000 1.000 1.000

1400004001 14 Almond, oil

- babyfood 0.050000 1.000 1.000

1400003001 14 Almond

- babyfood 0.050000 1.000 1.000

1400059000 14 Brazil nut 0.050000 1.000 1.000

1400068000 14 Butternut 0.050000 1.000 1.000

1400081000 14 Cashew 0.050000 1.000 1.000

1400092000 14 Chestnut 0.050000 1.000 1.000

1400155000 14 Hazelnut 0.050000 1.000 1.000

1400156000 14 Hazelnut, oil 0.050000 1.000 1.00 0

1400185000 14 Hickory nut 0.050000 1.000 1.000

1400213000 14 Macadamia nut 0.050000 1.000 1.000

1400269000 14 Pecan 0.050000 1.000 1.000

1400278000 14 Pine nut 0.050000 1.000 1.000

1400282000 14 Pistachio 0.050000 1.000 1.000

1400391000 14 Walnut 0.050000 1.000 1.000

1500027000 15 Barley, bran 0.050000 1.000 1.000Trifluralin Dietary Exposure and Risk Assessment DP Number: 4 10618

Page 14 of 27 1500026000 15 Barley, flour 0.050000 1.000 1.000

1500026001 15 Barley, flour

- babyfood 0.050000 1.000 1.000

1500025000 15 Barley, p earled barley 0.050000 1.000 1.000

1500025001 15 Barley, pearled barley

- babyfood 0.050000 1.000 1.000

1500122000 15 Corn, field, bran 0.050000 1.000 1.000

1500120000 15 Corn, field, flour 0.050000 1.000 1.000

1500120001 15 Corn, field, flour

- babyfood 0.050000 1.000 1.000

1500121000 15 Corn, field, meal 0.050000 1.000 1.000

1500121001 15 Corn, field, meal

- babyfood 0.050000 1.000 1.000

1500125000 15 Corn, field, oil 0.050000 1.000 1.000

1500125001 15 Corn, field, oil

- babyfood 0.050000 1.000 1.000

1500123000 15 Corn, field, starch 0.050000 1.000 1.000

1500123001 15 Corn, f ield, starch

- babyfood 0.050000 1.000 1.000

1500124000 15 Corn, field, syrup 0.050000 1.500 1.000

1500124001 15 Corn, field, syrup

- babyfood 0.050000 1.500 1.000

1500344000 15 Sorghum, grain 0.050000 1.000 1.000

1500345000 15 Sorghum, syrup 0.050000 1.000 1.000

1500401000 15 Wheat, grain 0.050000 1.000 1.000

1500401001 15 Wheat, grain

- babyfood 0.050000 1.000 1.00 0

2003114001 20C Coconut, oil

- babyfood 0.050000 1.000 1.000

2003128000 20C Cottonseed, oil 0.050000 1.000 1.000

2003128001 20C Cottonseed, oil

- babyfood 0.050000 1.000 1.000

2001163000 20A Flax seed, oil 0.050000 1.000 1.000

2001319000 20A Rapeseed, oil 0.050000 1.000 1.000

2001319001 20A Rapeseed, oil

- babyfood 0.050000 1.000 1.000

2002330000 20B Safflower, oil 0.050000 1.000 1.000

2002330001 20B Safflower, oil

- babyfood 0.050000 1.000 1.000

2001337000 20A Sesame, oil 0.050000 1.000 1.000

2001337001 20A Sesame, oil

- babyfood 0.050000 1.000 1.000

2001336000 20A Sesame, seed 0.050000 1.000 1.000

2001336001 20A Sesame, seed

- babyfood 0.050000 1.000 1.000

2002365000 20B Sunflower , oil 0.050000 1.000 1.000

2002365001 20B Sunflower, oil

- babyfood 0.050000 1.000 1.000

2002364000 20B Sunflower, seed 0.050000 1.000 1.000

8601000000 86A Water, direct, all sources 0.023800 1.000 1.000

8602000000 86B Water, indirect, all sources 0.023800 1.000 1.000



### Attachment 2: Acute Results File

US EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for TRIFLURALIN NHANES 2003

- 2008 2

- Day

Residue file: Trifluralin_acute_tolerance.r08 Adjustment factor #2 used.

Analysis Date: 01

- 31

- 2013/11:54:56 Residue file dated: 01

- 31

- 2013/11:52:33

NOEL (Acute) = 100.000000 mg/kg body

- wt/day

RAC/FF intake summed over 24 hours

Run Comment: "Females 13

- 50 yrs only (acute)"

===============================================================================

Summary calculations

-- per capita:

--- 95th Percentile

---- --- 99th Percentile

---- - -- 99.9th Percentile

----

Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- --------

Female 13

- 50:

0.002305 0.23 43390 0.003286 0.33 3 0427 0.005321 0.53 18793



### Attachment 3: Chronic Food plus Water Residue Input File

Filename: C: \ Documents and

Settings \ spiper \ Desktop \ Trifluralin \ Dietary \ Trifluralin_chronic_refined.r08

Chemical: TrifluralinTrifluralin Dietary Exposure and Risk Assessment DP Number: 4 10618

Page 15 of 27 RfD(Chronic): .024 mg/kg bw/day NOEL(Chronic): 2.4 mg/kg bw/day

RfD(Acute): 1 mg/kg bw/day NOEL(Acute): 100 mg/kg bw/day Q*= .0027

Date created/last modified: 01

- 31

- 2013/16:03:07 Program ver. 3.16, 03

- 08

- d

-------------------------------------------------------------------------- --------- EPA Crop Def Res Adj.Factors Comment

Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ -------

950 0019000 O Asparagus 0.050000 1.000 0.200

9500177000 O Grape, leaves 0.050000 1.000 0.025

9500178000 O Grape, raisin 0.050000 4.300 0.025

9500188000 O Hop 0.050000 1.000 1.000

9500263000 O Peanut 0.050000 1.000 0.050

9500264000 O Peanut, butter 0.050000 1.890 0.050

9500265000 O Peanut, oil 0. 050000 1.000 0.050

9500275000 O Peppermint 0.050000 1.000 1.000

9500276000 O Peppermint, oil 2.000000 1.000 1.000

9500352000 O Spearmint 0.050000 1.000 1.000

9 500353000 O Spearmint, oil 2.000000 1.000 1.000

9500363000 O Sugarcane, molasses 0.050000 1.000 0.050

9500363001 O Sugarcane, molasses

- babyfood 0.050000 1.000 0.050

9500362000 O Sugarcane, sugar 0.050000 1.000 0.050

9500362001 O Sugarcane, sugar

- babyfood 0.050000 1.000 0.050

0103015000 1CD Arrowroot, flour 0.050000 1.000 1.000

0103015001 1CD Arrowroot, flour

- babyfood 0.050000 1.000 1.000

0103017000 1CD Artichoke, Jerusalem 0.050000 1.000 1.000

0101050000 1AB Beet, garden, roots 0.050000 1.000 1.000

0101050001 1AB Beet, garden, roots

- babyfood 0.050000 1.000 1.000

0101052000 1A Beet, sugar 0.050000 1.000 0.025

0101053000 1A Beet, sugar, molasses 0.050000 1.000 0.025

0101053001 1A Beet, sugar, molasses

- babyfood 0.050000 1.000 0.025

0101052001 1A Beet, sugar

- babyfood 0.050000 1.000 0.025

0101067000 1AB Burdock 0.050000 1.000 1.000

0101078000 1AB Carrot 0.022000 1.000 0.400 PDP da

Full co mment: PDP data

0101079000 1AB Carrot, juice 0.022000 1.000 0.400 PDP da

Full comment: PDP data

0101078001 1AB Carrot

- babyfood 0.022000 1.000 0.400 PDP da

Full comment: PDP data

0103 082000 1CD Cassava 0.050000 1.000 1.000

0103082001 1CD Cassava

- babyfood 0.050000 1.000 1.000

0101084000 1AB Celeriac 0.050000 1.000 1.000

0101100000 1AB Chicory, root s 0.050000 1.000 1.000

0103139000 1CD Dasheen, corm 0.050000 1.000 1.000

0103166000 1CD Ginger 0.050000 1.000 1.000

0103167000 1CD Ginger, dried 0.0 50000 1.000 1.000

0103166001 1CD Ginger

- babyfood 0.050000 1.000 1.000

0101168000 1AB Ginseng, dried 0.050000 1.000 1.000

0101190000 1AB Horseradish 0.050000 1.000 1.000

01 01250000 1AB Parsley, turnip rooted 0.050000 1.000 1.000

0101251000 1AB Parsnip 0.050000 1.000 1.000

0101251001 1AB Parsnip

- babyfood 0.050000 1.000 1.000

0103296000 1C Potato, chi ps 0.009000 1.000 0.025 PDP da

Full comment: PDP data

0103297000 1C Potato, dry (granules/ flakes) 0.009000 6.500 0.025 PDP da

Full comment: PDP data

0103297001 1C Potato, dry (granules/ flakes)

- b 0.009000 6.500 0.025 PDP da

Full comment: PDP data

0103298000 1C Potato, flour 0.009000 1.000 0.025 PDP da

Full comment: PDP data

0103298001 1C Potato, flour

- babyfood 0.009000 1.000 0.025 PDP da

Full comment: PDP data

0103300000 1C Potato, tuber, w/o peel 0.009000 1.000 0.025 PDP da

Full comment: PDP data

0103300001 1C Potato, tuber, w/o peel

- babyfood 0.009000 1.000 0.025 PDP da

Full comment: PDP data

0103299000 1C Potato, tuber, w/peel 0.009000 1.000 0.025 PDP daTrifluralin Dietary Exposure and Risk Assessment DP Number: 4 10618

Page 16 of 27 Full comment: PDP data

0103299001 1C Potato, tuber, w/peel

- babyfood 0.009000 1.000 0.025 PDP da

Full comment : PDP data

0101316000 1AB Radish, Oriental, roots 0.050000 1.000 1.000

0101314000 1AB Radish, roots 0.050000 1.000 1.000

0101327000 1AB Rutabaga 0.050000 1.000 1.000

0101331000 1AB Salsify, roots 0.050000 1.000 1.000

0103366000 1CD Sweet potato 0.050000 1.000 1.000

0103366001 1CD Sweet potato

- babyfood 0.050000 1.000 1.000

0103371000 1CD Tanier, corm 0.050000 1.000 1.000

0103387000 1CD Turmeric 0.050000 1.000 1.000

0101388000 1AB Turnip, roots 0.050000 1.000 1.000

0103407000 1CD Yam bean 0.050000 1. 000 1.000

0103406000 1CD Yam, true 0.050000 1.000 1.000

0200051000 2 Beet, garden, tops 0.050000 1.000 1.000

0200101000 2 Chicory, tops 0.050000 1.000 1.000

0200140000 2 Dasheen, leaves 0.050000 1.000 1.000

0200317000 2 Radish, Oriental, tops 0.050000 1.000 1.000

0200315000 2 Radish, tops 0.050000 1.000 1.000

0200332000 2 Salsify, tops 0.050000 1.000 1.000

0302103000 3B Chive, fresh leaves 0.050000 1.000 1.000

0301165000 3A Garlic, bulb 0.050000 1.000 0.050

0301165001 3A Garlic, b ulb

- babyfood 0.050000 1.000 0.050

0302198000 3B Leek 0.050000 1.000 1.000

0301237000 3A Onion, bulb 0.050000 1.000 0.025

0301238000 3A Onion, bulb, dried 0.050000 9.000 0.025

0301238001 3A Onion, bulb, dried

- babyfood 0.050000 9.000 0.025

0301237001 3A Onion, bulb

- babyfood 0.050000 1.000 0.025

0302239000 3B Onion, green 0.050000 1.000 0.025

0301338000 3A Shallot, bulb 0.050000 1.000 1.000

0302338500 3B Shallot, fresh leaves 0.050000 1.000 1.000

0402085000 4B Celery 0.050000 1.000 0.025

0402086000 4B Celery, juice 0.050000 1.000 0.025

0402085001 4B Celery

- babyfood 0.050000 1.000 0.025

0401150000 4A Endive 0.050000 1.000 1.000

0501061000 5A Broccoli 0.050000 1.000 0.100

0502063000 5B Broccoli raab 0.050000 1.000 1.000

0501062000 5A Broccoli, Chinese 0.050000 1.000 1.000

0501061001 5A Broccoli

- babyfood 0.050000 1.000 0.10 0

0501064000 5A Brussels sprouts 0.050000 1.000 1.000

0501069000 5A Cabbage 0.050000 1.000 0.400

0502070000 5B Cabbage, Chinese, bok choy 0.050000 1.000 1.000

0501072000 5A Cabba ge, Chinese, mustard 0.050000 1.000 1.000

0501071000 5A Cabbage, Chinese, napa 0.050000 1.000 1.000

0501083000 5A Cauliflower 0.050000 1.000 0.100

0502117000 5B Collards 0.050000 1.000 1.000

0502194000 5B Kale 0.050000 1.000 1.000

0501196000 5A Kohlrabi 0.050000 1.000 1.000

0502229000 5B Mustard greens 0.050000 1.000 1.000

0502318000 5B Rape greens 0.050000 1.000 1.000

0502389000 5B Turnip, greens 0.050000 1.000 1.000

0603035000 6C Bean, gr eat northern, seed 0.050000 1.000 0.100

0603030000 6C Bean, black, seed 0.050000 1.000 0.100

0603032000 6C Bean, broad, seed 0.050000 1.000 0.100

0602031000 6B Bean, broad, succulent 0.050000 1.000 0.250

0603034000 6C Bean, cowpea, seed 0.050000 1.000 0.100

0602033000 6B Bean, cowpea, succulent 0.050000 1.000 0.250

0603036000 6C Bean, kidney, seed 0.050000 1.000 0.100

0603038000 6C Bean, lima, seed 0.050000 1.000 0.100

0602037000 6B Bean, lima, succulent 0.050000 1.000 0.250

0603039000 6C Bean, mung, seed 0.050000 1.000 0.100

0603040000 6C Bean, n avy, seed 0.050000 1.000 0.100

0603041000 6C Bean, pink, seed 0.050000 1.000 0.100

0603042000 6C Bean, pinto, seed 0.050000 1.000 0.100

0601043000 6A Bean, snap, succulent 0.050000 1.000 0.250

0601043001 6A Bean, snap, succulent

- babyfood 0.050000 1.000 0.250Trifluralin Dietary Exposure and Risk Assessment DP Number: 4 10618

Page 17 of 27 0603099000 6C Chickpea, flour 0.050000 1.000 1.000

0603098000 6C Chickpea, seed 0.050000 1.000 1.00 0

0603098001 6C Chickpea, seed

- babyfood 0.050000 1.000 1.000

0603182000 6C Guar, seed 0.050000 1.000 1.000

0603182001 6C Guar, seed

- babyfood 0.050000 1.000 1.000

0603203000 6C Lenti l, seed 0.050000 1.000 1.000

0603256000 6C Pea, dry 0.050000 1.000 0.100

0603256001 6C Pea, dry

- babyfood 0.050000 1.000 0.100

0601257000 6A Pea, edible podded, succulent 0.050000 1.000 0.100

0603258000 6C Pea, pigeon, seed 0.050000 1.000 0.100

0602259000 6B Pea, pigeon, succulent 0.050000 1.000 0.100

0602255000 6B Pea, succ ulent 0.050000 1.000 0.100

0602255001 6B Pea, succulent

- babyfood 0.050000 1.000 0.100

0603348000 6C Soybean, flour 0.050000 1.000 0.050

0603348001 6C Soybean, flour

- babyfood 0.050000 1.000 0.050

0600350000 6 Soybean, oil 0.050000 1.000 0.050

0600350001 6 Soybean, oil

- babyfood 0.050000 1.000 0.050

0600347000 6 Soybean, seed 0.050000 1.000 0.050

0600349000 6 Soybean, soy milk 0.050000 1.000 0.050

0600349001 6 Soybean, soy milk

- babyfood or in 0.050000 1.000 0.050

0601349500 6AB Soybean, vegetable 0.050000 1.000 0.050

0802148000 8BC Eggplan t 0.050000 1.000 1.000

0802234000 8BC Okra 0.050000 1.000 1.000

0802270000 8B Pepper, bell 0.001000 1.000 0.250 PDP da

Full comment: PDP data

0802271 000 8B Pepper, bell, dried 0.001000 1.000 0.250 PDP da

Full comment: PDP data

0802271001 8B Pepper, bell, dried

- babyfood 0.001000 1.000 0.250 PDP da

Full comment: PDP data

0802270001 8B Pepper, bel l

- babyfood 0.001000 1.000 0.250 PDP da

Full comment: PDP data

0802272000 8BC Pepper, nonbell 0.001000 1.000 0.250 PDP da

Full comment: PDP data

0802273000 8BC Pepper, nonbell, dried 0.001000 1.000 0.250 PDP da

Full comment: PDP data

0802272001 8BC Pepper, nonbell

- babyfood 0.001000 1.000 0.250 PDP da

Full comment: PDP data

0801374000 8A Tomatillo 0.010000 1.000 0.600 PDP da

Full comment: PDP data

0801375000 8A Tomato 0.010000 1.000 0.600 PDP da

Full comment: PDP data

0801380000 8A Tomato, Tree 0.010000 1.000 0.600 PDP da

Full comment: PDP data

0801378000 8A Tomato, dried 0.010000 14.300 0.600 PDP da

Full comment: PDP data

0801378001 8A Tomato, dried

- babyfood 0.010000 14.300 0.600 PDP da

Full comment : PDP data

0801379000 8A Tomato, juice 0.010000 1.500 0.600 PDP da

Full comment: PDP data

0801376000 8A Tomato, paste 0.047500 1.000 0.600 PDP da

Full comment: PDP data

080137600 1 8A Tomato, paste

- babyfood 0.047500 1.000 0.600 PDP da

Full comment: PDP data

0801377000 8A Tomato, puree 0.010000 3.300 0.600 PDP da

Full comment: PDP data

0801377001 8A Tomato, puree

- babyfood 0.010000 3.300 0.600 PDP da

Full comment: PDP data

0801375001 8A Tomato

- babyfood 0.010000 1.000 0.600 PDP da

Full comment: PDP data

0902021000 9B Balsam pear 0.050000 1.000 1.000

0901075000 9A Cantaloupe 0.022000 1.000 0.250 PDP da

Full comment: PDP data

0902088000 9B Chayote, fruit 0.050000 1.000 1.000

0902102000 9B Chinese waxgourd 0.050000 1.000 1.000

0902135000 9B Cucumber 0.050000 1.000 0.025

0901187000 9A Honeydew melon 0.050000 1.000 0.200Trifluralin Dietary Exposure and Risk Assessment DP Number: 4 10618

Page 18 of 27 0902308000 9B Pumpkin 0.050000 1.000 0.050

0902309000 9B Pumpkin, seed 0.050000 1.000 0.050

0902356000 9B Squash, summer 0.050000 1.000 0.050

0902356001 9B Squash, s ummer

- babyfood 0.050000 1.000 0.050

0902357000 9B Squash, winter 0.050000 1.000 0.050

0902357001 9B Squash, winter

- babyfood 0.050000 1.000 0.050

0901399000 9A Watermelon 0.050000 1.000 0.100

0901400000 9A Watermelon, juice 0.050000 1.000 0.100

1001106000 10A Citron 0.050000 1.000 1.000

1001107000 10A Citrus hybrids 0.050000 1.000 1.000

1001108000 10A Citrus, oil 0.050000 1.000 1.000

1003180000 10C Grapefruit 0.050000 1.000 0.010

1003181000 10C Grapefruit, juice 0.050000 1.200 0.010

1002197000 10B Kumquat 0.050000 1.000 1.000

1002199000 10B Lemon 0.050000 1.000 0.010

1002200000 10B Lemon, juice 0.050000 2.000 0.010

1002200001 10B Lemon, juice

- babyfood 0.050000 2.000 0.010

1002201000 10B Lemon, peel 0.050000 1.000 0.010

1002206000 10B Lime 0.050000 1.000 1.000

1002207000 10B Lime, juice 0.050000 2.000 1.00 0

1002207001 10B Lime, juice

- babyfood 0.050000 2.000 1.000

1001240000 10A Orange 0.015000 1.000 0.010 PDP da

Full comment: PDP data

1001241000 10A Orange, juice 0.0005 00 1.000 0.010 PDP da

Full comment: PDP data

1001241001 10A Orange, juice

- babyfood 0.000500 1.000 0.010 PDP da

Full comment: PDP data

1001242000 10A Orange, peel 0.015000 1.000 0.010 PDP da

Full comment: PDP data

1003307000 10C Pummelo 0.050000 1.000 1.000

1001369000 10A Tangerine 0.050000 1.000 1.000

1001370000 10A Tangerine, juice 0.050000 2.300 1.000

1202012000 12B Apricot 0.050000 1.000 1.000

1202013000 12B Apricot, dried 0.050000 6.000 1.000

1202014000 12B Apricot, juice 0.050000 1.000 1.000

12020140 01 12B Apricot, juice

- babyfood 0.050000 1.000 1.000

1202012001 12B Apricot

- babyfood 0.050000 1.000 1.000

1201090000 12A Cherry 0.050000 1.000 1.000

1201091000 12A Cherry, juice 0.050000 1.500 1.000

1201091001 12A Cherry, juice

- babyfood 0.050000 1.500 1.000

1201090001 12A Cherry

- babyfood 0.050000 1.000 1.000

1202230000 12B Nectarine 0.05000 0 1.000 1.000

1202260000 12B Peach 0.050000 1.000 0.010

1202261000 12B Peach, dried 0.050000 7.000 0.010

1202261001 12B Peach, dried

- babyfood 0.050000 7.000 0.010

120226 2000 12B Peach, juice 0.050000 1.000 0.010

1202262001 12B Peach, juice

- babyfood 0.050000 1.000 0.010

1202260001 12B Peach

- babyfood 0.050000 1.000 0.010

1203285000 12C Plum 0.050000 1.000 1.000

1203287000 12C Plum, prune, dried 0.050000 5.000 1.000

1203287001 12C Plum, prune, dried

- babyfood 0.050000 5.000 1.000

1203286000 12C Plum, prune, fresh 0.050 000 1.000 1.000

1203286001 12C Plum, prune, fresh

- babyfood 0.050000 1.000 1.000

1203288000 12C Plum, prune, juice 0.050000 1.400 1.000

1203288001 12C Plum, prune, juice

- babyfood 0.050000 1.400 1.000

1203285001 12C Plum

- babyfood 0.050000 1.000 1.000

1304175000 13D Grape 0.050000 1.000 0.025

1304176000 13D Grape, juice 0.050000 1.200 0.025

1304176001 13D Grape, ju ice

- babyfood 0.050000 1.200 0.025

1304179000 13D Grape, wine and sherry 0.050000 1.000 0.025

1400003000 14 Almond 0.050000 1.000 0.010

1400004000 14 Almond, oil 0.050000 1.000 0.010

1400004001 14 Almond, oil

- babyfood 0.050000 1.000 0.010

1400003001 14 Almond

- babyfood 0.050000 1.000 0.010

1400059000 14 Brazil nut 0.050000 1.000 1.000

1400068000 14 Butternut 0.050000 1.000 1.000Trifluralin Dietary Exposure and Risk Assessment DP Number: 4 10618

Page 19 of 27 1400081000 14 Cashew 0.050000 1.000 1.000

1400092000 14 Chestnut 0.050000 1.000 1.000

1400155000 14 Hazelnu t 0.050000 1.000 1.000

1400156000 14 Hazelnut, oil 0.050000 1.000 1.000

1400185000 14 Hickory nut 0.050000 1.000 1.000

1400213000 14 Macadamia nut 0.050000 1.000 1.000

1400269000 14 Pecan 0.050000 1.000 0.010

1400278000 14 Pine nut 0.050000 1.000 1.000

1400282000 14 Pistachio 0.050000 1.000 0.02 5

1400391000 14 Walnut 0.050000 1.000 0.010

1500027000 15 Barley, bran 0.050000 1.000 0.010

1500026000 15 Barley, flour 0.050000 1.000 0.010

1500026001 15 Barle y, flour

- babyfood 0.050000 1.000 0.010

1500025000 15 Barley, pearled barley 0.050000 1.000 0.010

1500025001 15 Barley, pearled barley

- babyfood 0.050000 1.000 0.010

1500122000 15 Corn, field, bran 0.050000 1.000 0.010

1500120000 15 Corn, field, flour 0.050000 1.000 0.010

1500120001 15 Corn, field, flour

- babyfood 0.050000 1.000 0.010

1500121000 15 Corn, field, meal 0.050000 1.000 0.010

1500121001 15 Corn, field, meal

- babyfood 0.050000 1.000 0.010

1500125000 15 Corn, field, oil 0.050000 1.000 0.010

1500125001 15 Corn, fie ld, oil

- babyfood 0.050000 1.000 0.010

1500123000 15 Corn, field, starch 0.050000 1.000 0.010

1500123001 15 Corn, field, starch

- babyfood 0.050000 1.000 0.010

1500124000 15 Corn, field, syrup 0.050000 1.500 0.010

1500124001 15 Corn, field, syrup

- babyfood 0.050000 1.500 0.010

1500344000 15 Sorghum, grain 0.050000 1.000 0.010

1500345000 15 Sorghum, syrup 0.050000 1.000 0.010

1500401000 15 Wheat, grain 0.050000 1.000 0.010

1500401001 15 Wheat, grain

- babyfood 0.050000 1.000 0.010

2003114001 20C Coconut, oil

- babyfood 0.050000 1.000 1.000

2003128000 20C Cottons eed, oil 0.050000 1.000 0.300

2003128001 20C Cottonseed, oil

- babyfood 0.050000 1.000 0.300

2001163000 20A Flax seed, oil 0.050000 1.000 1.000

2001319000 20A Rapeseed, oil 0.050000 1.000 0.025

2001319001 20A Rapeseed, oil

- babyfood 0.050000 1.000 0.025

2002330000 20B Safflower, oil 0.050000 1.000 1.000

2002330001 20B Safflower, oil

- babyfood 0.050000 1.000 1.00 0

2001337000 20A Sesame, oil 0.050000 1.000 1.000

2001337001 20A Sesame, oil

- babyfood 0.050000 1.000 1.000

2001336000 20A Sesame, seed 0.050000 1.000 1.000

2001336001 20A Sesam e, seed

- babyfood 0.050000 1.000 1.000

2002365000 20B Sunflower, oil 0.050000 1.000 0.100

2002365001 20B Sunflower, oil

- babyfood 0.050000 1.000 0.100

2002364000 20B Sunflower, seed 0.050000 1.000 0.100

8601000000 86A Water, direct, all sources 0.001970 1.000 1.000

8602000000 86B Water, indirect, all sources 0.001970 1.000 1.000



### Attachment 4: Chronic Results File

US EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID Chronic analysis for TRIFLURALIN NHANES 2003

- 2008 2

- day

Residue file name: C: \ Documents and

Settings \ spiper \ Desktop \ Trifluralin \ Dieta ry \ Trifluralin_chronic_refined.r08

Adjustment factor #2 used.

Analysis Date 01

- 31

- 2013/16:07:33 Residue file dated: 01

- 31

- 2013/16:03:07

Reference dose (RfD, Chronic) = .024 mg/kg bw/day

============= ==================================================================

Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Percent of

Subgroup body wt/day RfdTrifluralin Dietary Exposure and Risk Assessment DP Number: 4 10618

Page 20 of 27 -------------------------------------- ------------- ----------------

Total US Population 0.000078 0.3%

Hispanic 0.000077 0.3%

Non

- Hisp

- White 0.000078 0.3%

Non

- Hisp

- Black 0.000071 0.3%

Non

- Hisp

- Other 0.000093 0.4%

Nursing Infants 0.000115 0.5%

Non

- Nursing Infants 0.000257 1.1%

Female 13+ PREG 0.000074 0.3%

Children 1

- 6 0.000136 0.6%

Children 7

- 12 0.000077 0.3%

Male 13

- 19 0.000053 0.2%

Female 13

- 19/NP 0.000057 0.2%

Male 20+ 0.000067 0.3%

Female 20+/NP 0.000075 0.3%

Seniors 55+ 0.000074 0.3%

All Infants 0.000213 0.9%

Female 13

- 50 0.000070 0.3%

Children 1

- 2 0.000158 0.7%

Children 3

- 5 0.000128 0.5%

Children 6

- 12 0.000082 0.3%

Youth 13

- 19 0.000055 0.2%

Adults 20

- 49 0.000070 0.3%

Adults 50

- 99 0.000074 0.3%

Female 13

- 49 0.000070 0.3%

-------------------------------------------------------------------------------



### Attachment 3: C ancer Food plus Water Residue Input File

Filename: C: \ Documents and

Settings \ spiper \ Desktop \ Trifluralin \ Dietary \ Trifluralin_cancer_refined.r08

Chemical: Trifluralin

RfD(Chronic): .024 mg/kg bw/day NOEL(Chronic): 2.4 mg/kg bw/day

RfD(Acute): 1 mg/kg bw/day NOEL(Acute): 100 mg/kg bw/day Q*= .00296

Date created/last modifi ed: 01

- 31

- 2013/16:13:57 Program ver. 3.16, 03

- 08

- d

Comment: Cancer

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment

Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 9500019000 O Asparagus 0.050000 1.000 0.200

9500177000 O Grape, leaves 0.050000 1.000 0.025

9500178000 O Grape, raisin 0.050000 4.300 0.025

9500188000 O Hop 0.050000 1.000 1.000

9500263000 O Peanut 0.050000 1.000 0.050

9500264000 O Peanut, butter 0.050000 1.890 0.050

9500265000 O Peanut, oil 0.050000 1.000 0.050

9500275000 O Peppermin t 0.050000 1.000 1.000

9500276000 O Peppermint, oil 2.000000 1.000 1.000

9500352000 O Spearmint 0.050000 1.000 1.000

9500353000 O Spearmint, oil 2.000000 1.000 1.000

9500363000 O Sugarcane, molasses 0.050000 1.000 0.050

9500363001 O Sugarcane, molasses

- babyfood 0.050000 1.000 0.050

9500362000 O Sugarcane, sugar 0.050000 1.000 0.050

9500362001 O Sugarcane, sugar

- babyfood 0.050000 1.000 0.050

0103015000 1CD Arrowroot, flour 0.050000 1.000 1.000

0103015001 1CD Arrowroot, flour

- babyfood 0.050000 1.000 1.000

0103017000 1CD Articho ke, Jerusalem 0.050000 1.000 1.000

0101050000 1AB Beet, garden, roots 0.050000 1.000 1.000

0101050001 1AB Beet, garden, roots

- babyfood 0.050000 1.000 1.000

0101052000 1A Beet, sugar 0.050000 1.000 0.025

0101053000 1A Beet, sugar, molasses 0.050000 1.000 0.025

0101053001 1A Beet, sugar, molasses

- babyfood 0.050000 1.000 0.025

0101052001 1A Beet, sugar

- babyfood 0.050000 1.000 0.02 5Trifluralin Dietary Exposure and Risk Assessment DP Number: 4 10618

Page 21 of 27 0101067000 1AB Burdock 0.050000 1.000 1.000

0101078000 1AB Carrot 0.022000 1.000 0.400 PDP da

Full comment: PDP data

0101079000 1AB Carrot, juice 0.0220 00 1.000 0.400 PDP da

Full comment: PDP data

0101078001 1AB Carrot

- babyfood 0.022000 1.000 0.400 PDP da

Full comment: PDP data

0103082000 1CD Cassava 0.050000 1.000 1.000

0103082001 1CD Cassava

- babyfood 0.050000 1.000 1.000

0101084000 1AB Celeriac 0.050000 1.000 1.000

0101100000 1AB Chicory, roots 0.050000 1.000 1.000

0103139000 1CD Dasheen, corm 0.050000 1.000 1.000

0103166000 1CD Ginger 0.050000 1.000 1.000

0103167000 1CD Ginger, dried 0.050000 1.000 1.000

0103166001 1CD Ginger

- babyfood 0.050000 1.000 1.000

0101168000 1AB Ginseng, dried 0.050000 1.000 1.000

0101190000 1AB Horseradish 0.050000 1.000 1.000

0101250000 1AB Parsley, turnip rooted 0.050000 1.000 1.000

0101251000 1AB Parsnip 0.050000 1.000 1.000

0101251001 1AB Parsnip

- babyfood 0.050000 1.000 1.000

0103296000 1C Potato, chips 0.009000 1.000 0.025 PDP da

Full comment: PDP data

0103297000 1C Potato, dry (granules/ flakes) 0.009000 6.500 0.025 PDP da

Full comment: PDP data

0103297001 1C Potato, dry (granules/ flakes)

- b 0.009000 6.500 0.025 PDP da

Full comment: PDP data

01 03298000 1C Potato, flour 0.009000 1.000 0.025 PDP da

Full comment: PDP data

0103298001 1C Potato, flour

- babyfood 0.009000 1.000 0.025 PDP da

Full comment: PDP data

0103300000 1C Potato , tuber, w/o peel 0.009000 1.000 0.025 PDP da

Full comment: PDP data

0103300001 1C Potato, tuber, w/o peel

- babyfood 0.009000 1.000 0.025 PDP da

Full comment: PDP data

0103299000 1C Potato, tuber, w/peel 0.009000 1.000 0.025 PDP da

Full comment: PDP data

0103299001 1C Potato, tuber, w/peel

- babyfood 0.009000 1.000 0.025 PDP da

Full comment: PDP data

0101316000 1AB Radish, Oriental, roots 0.050000 1.000 1.000

0101314000 1AB Radish, roots 0.050000 1.000 1.000

0101327000 1AB Rutabaga 0.050000 1.000 1.000

0101331000 1AB Salsify, roots 0.050000 1.000 1.000

0103366000 1CD Sweet potato 0.050000 1.000 1.000

0103366001 1CD Sweet potato

- babyfood 0.050000 1.000 1.000

0103371000 1CD Tanier, corm 0.050000 1.000 1.000

0103387000 1CD Turmeric 0.050000 1.000 1.000

0101388000 1AB Turnip, roots 0.050000 1.000 1.000

0103407000 1CD Yam bean 0.050000 1.000 1.000

0103406000 1CD Yam, true 0.050000 1.000 1.000

0200051000 2 Beet, garden, tops 0.050000 1.000 1.000

0200101000 2 Chicory, tops 0.050000 1.000 1.000

0200140000 2 Dasheen , leaves 0.050000 1.000 1.000

0200317000 2 Radish, Oriental, tops 0.050000 1.000 1.000

0200315000 2 Radish, tops 0.050000 1.000 1.000

0200332000 2 Salsify, tops 0.050000 1.000 1.000

0302103000 3B Chive, fresh leaves 0.050000 1.000 1.000

0301165000 3A Garlic, bulb 0.050000 1.000 0.050

0301165001 3A Garlic, bulb

- babyfood 0.050000 1.000 0.05 0

0302198000 3B Leek 0.050000 1.000 1.000

0301237000 3A Onion, bulb 0.050000 1.000 0.025

0301238000 3A Onion, bulb, dried 0.050000 9.000 0.025

0301238001 3A Onion , bulb, dried

- babyfood 0.050000 9.000 0.025

0301237001 3A Onion, bulb

- babyfood 0.050000 1.000 0.025

0302239000 3B Onion, green 0.050000 1.000 0.025

0301338000 3A Shallot, bulb 0.050000 1.000 1.000

0302338500 3B Shallot, fresh leaves 0.050000 1.000 1.000Trifluralin Dietary Exposure and Risk Assessment DP Number: 4 10618

Page 22 of 27 0402085000 4B Celery 0.050000 1.000 0.025

0402086000 4B Celery, j uice 0.050000 1.000 0.025

0402085001 4B Celery

- babyfood 0.050000 1.000 0.025

0401150000 4A Endive 0.050000 1.000 1.000

0501061000 5A Broccoli 0.050000 1.000 0.100

0502063000 5B Broccoli raab 0.050000 1.000 1.000

0501062000 5A Broccoli, Chinese 0.050000 1.000 1.000

0501061001 5A Broccoli

- babyfood 0.050000 1.000 0.100

0501064000 5A Brussels sprouts 0.050000 1.000 1.000

0501069000 5A Cabbage 0.050000 1.000 0.400

0502070000 5B Cabbage, Chinese, bok choy 0.050000 1.000 1.000

0501072000 5A Cabbage , Chinese, mustard 0.050000 1.000 1.000

0501071000 5A Cabbage, Chinese, napa 0.050000 1.000 1.000

0501083000 5A Cauliflower 0.050000 1.000 0.100

0502117000 5B Collards 0.050000 1.000 1.000

0502194000 5B Kale 0.050000 1.000 1.000

0501196000 5A Kohlrabi 0.050000 1.000 1.000

0502229000 5B Mustard greens 0.050000 1.000 1.00 0

0502318000 5B Rape greens 0.050000 1.000 1.000

0502389000 5B Turnip, greens 0.050000 1.000 1.000

0603035000 6C Bean, great northern, seed 0.050000 1.000 0.100

0603030000 6C Bean, black, seed 0.050000 1.000 0.100

0603032000 6C Bean, broad, seed 0.050000 1.000 0.100

0602031000 6B Bean, broad, succulent 0.050000 1.000 0.250

0603034000 6C Bean, cowpea, seed 0.050000 1.000 0.100

0602033000 6B Bean, cowpea, succulent 0.050000 1.000 0.250

0603036000 6C Bean, kidney, seed 0.050000 1.000 0.100

0603038000 6C Bean, lima, seed 0.050000 1.000 0.100

0602037000 6B Bean, lima, succulent 0.050000 1.000 0.250

0603039000 6C Bean, mung, seed 0.050000 1.000 0.100

0603040000 6C Bean, nav y, seed 0.050000 1.000 0.100

0603041000 6C Bean, pink, seed 0.050000 1.000 0.100

0603042000 6C Bean, pinto, seed 0.050000 1.000 0.100

0601043000 6A Bean, snap, succulent 0.050000 1.000 0.250

0601043001 6A Bean, snap, succulent

- babyfood 0.050000 1.000 0.250

0603099000 6C Chickpea, flour 0.050000 1.000 1.000

0603098000 6C Chickpea, seed 0.050000 1.000 1.000

0603098001 6C Chickpea, seed

- babyfood 0.050000 1.000 1.000

0603182000 6C Guar, seed 0.050000 1.000 1.000

0603182001 6C Guar, seed

- babyfood 0.050000 1.000 1.000

0603203000 6C Lentil, seed 0.050000 1.000 1.000

0603256000 6C Pea, dry 0.050000 1.000 0.100

0603256001 6C Pea, dry

- babyfood 0.050000 1.000 0.100

0601257000 6A Pea, edible podded, succulent 0.050000 1.000 0.100

0603258000 6C Pea, pigeon, seed 0.050000 1.000 0.100

0602259000 6B Pea, pigeon, succulent 0.050000 1.000 0.100

0602255000 6B Pea, succulent 0.050000 1.000 0.10 0

0602255001 6B Pea, succulent

- babyfood 0.050000 1.000 0.100

0603348000 6C Soybean, flour 0.050000 1.000 0.050

0603348001 6C Soybean, flour

- babyfood 0.050000 1.000 0.050

0600350000 6 Soybe an, oil 0.050000 1.000 0.050

0600350001 6 Soybean, oil

- babyfood 0.050000 1.000 0.050

0600347000 6 Soybean, seed 0.050000 1.000 0.050

0600349000 6 Soybean, soy milk 0.050000 1.000 0.050

0600349001 6 Soybean, soy milk

- babyfood or in 0.050000 1.000 0.050

0601349500 6AB Soybean, vegetable 0.050000 1.000 0.050

0802148000 8BC Eggplant 0.050000 1.000 1.000

0802234000 8BC Okra 0.050000 1.000 1.000

0802270000 8B Pepper, bell 0.001000 1.000 0.250 PDP da

Full comment: PDP data

080227100 0 8B Pepper, bell, dried 0.001000 1.000 0.250 PDP da

Full comment: PDP data

0802271001 8B Pepper, bell, dried

- babyfood 0.001000 1.000 0.250 PDP da

Full comment: PDP data

0802270001 8B Pepper, bell

- babyfood 0.001000 1.000 0.250 PDP da

Full comment: PDP dataTrifluralin Dietary Exposure and Risk Assessment DP Number: 4 10618

Page 23 of 27 0802272000 8BC Pepper, nonbell 0.001000 1.000 0.250 PDP da

Full comment: PDP data

0802273000 8BC Pepper, nonbell, dried 0.001000 1.000 0.250 PDP da

Full comment: PDP data

0802272001 8BC Pepper, nonbell

- babyfood 0.001000 1.000 0.250 PDP da

Full comment: PDP data

0801374000 8A Tomatillo 0.010000 1.000 0.600 PDP da

Full comment: PDP data

0801375000 8A Tomato 0.010000 1.000 0.600 PDP da

Full comment: PDP data

0801380000 8A Tomato, Tree 0.010000 1.000 0.600 PDP da

Full comment: PDP data

0801378000 8A Tomato, dried 0.010000 14.300 0.600 PDP da

Full comment: PDP data

0801378001 8A Tomato, dried

- babyfood 0.010000 14.300 0.600 PDP da

Full comment: PDP data

0801379000 8A Tomato, juice 0.010000 1.500 0.600 PDP da

Full comment: PDP data

0801376000 8A Tomato, paste 0.047500 1.000 0.600 PDP da

Full com ment: PDP data

0801376001 8A Tomato, paste

- babyfood 0.047500 1.000 0.600 PDP da

Full comment: PDP data

0801377000 8A Tomato, puree 0.010000 3.300 0.600 PDP da

Full comment: PDP data

08013 77001 8A Tomato, puree

- babyfood 0.010000 3.300 0.600 PDP da

Full comment: PDP data

0801375001 8A Tomato

- babyfood 0.010000 1.000 0.600 PDP da

Full comment: PDP data

0902021000 9B Balsam pe ar 0.050000 1.000 1.000

0901075000 9A Cantaloupe 0.022000 1.000 0.250 PDP da

Full comment: PDP data

0902088000 9B Chayote, fruit 0.050000 1.000 1.000

090210200 0 9B Chinese waxgourd 0.050000 1.000 1.000

0902135000 9B Cucumber 0.050000 1.000 0.025

0901187000 9A Honeydew melon 0.050000 1.000 0.200

0902308000 9B Pumpkin 0.050000 1.000 0.050

0902309000 9B Pumpkin, seed 0.050000 1.000 0.050

0902356000 9B Squash, summer 0.050000 1.000 0.050

0902356001 9B Squash, summer

- babyfood 0.050000 1.000 0.050

0902357000 9B Squash, winter 0.050000 1.000 0.050

0902357001 9B Squash, winter

- babyfood 0.050000 1.000 0.050

0901399000 9A Watermelon 0.050000 1.000 0.100

0901400 000 9A Watermelon, juice 0.050000 1.000 0.100

1001106000 10A Citron 0.050000 1.000 1.000

1001107000 10A Citrus hybrids 0.050000 1.000 1.000

1001108000 10A Citrus, oil 0.050000 1.000 1.000

1003180000 10C Grapefruit 0.050000 1.000 0.010

1003181000 10C Grapefruit, juice 0.050000 1.200 0.010

1002197000 10B Kumquat 0.050000 1.000 1.000

1002199000 10B Lemon 0.050000 1.000 0.010

1002200000 10B Lemon, juice 0.050000 2.000 0.010

1002200001 10B Lemon, juice

- babyfood 0.050000 2.000 0.010

1002201000 10B Lemon, peel 0.050000 1.000 0.010

1002206000 10B Lime 0.050000 1.000 1.000

1002207000 10B Lime, juice 0.050000 2.000 1.000

1002207001 10B Lime, juice

- babyfood 0.050000 2.000 1.000

1001240000 10A Orange 0.015000 1.000 0.010 PDP da

Full comment: PDP data

1001241000 10A Orange, juice 0.000500 1.000 0.010 PDP da

Full comment: PDP data

1001241001 10A Orange, juice

- babyfood 0.000500 1.000 0.010 PDP da

Full comment: PDP data

1001242000 10A Orange, peel 0.015000 1.000 0.010 PDP da

Full comment: PDP data

1003307000 10C Pummelo 0.050000 1.000 1.000

1001369000 10A Tangerine 0.050000 1.000 1.000Trifluralin Dietary Exposure and Risk Assessment DP Number: 4 10618

Page 24 of 27 1001370000 10A Tangerine, juice 0.050000 2 .300 1.000

1202012000 12B Apricot 0.050000 1.000 1.000

1202013000 12B Apricot, dried 0.050000 6.000 1.000

1202014000 12B Apricot, juice 0.050000 1.000 1.000

1202014001 12B Apricot, juice

- babyfood 0.050000 1.000 1.000

1202012001 12B Apricot

- babyfood 0.050000 1.000 1.000

1201090000 12A Cherry 0.050000 1.000 1.000

1201091000 12A Cherry, juice 0.050000 1.500 1.000

1201091001 12A Cherry, juice

- babyfood 0.050000 1.500 1.000

1201090001 12A Cherry

- babyfood 0.050000 1.000 1.000

1202230000 12B Nectarine 0.050000 1.000 1.000

1202260000 12B Peach 0.050000 1.000 0.010

1202261000 12B Peach, dried 0.050000 7.000 0.010

1202261001 12B Peach, dried

- babyfood 0.050000 7.000 0.010

1202262000 12B Peach, juice 0.050000 1.000 0.010

1202262001 12B Peach, juice

- babyfood 0.050000 1.000 0.010

1202260001 12B Peach

- babyfood 0.050000 1.000 0.010

1203285000 12C Plum 0.050000 1.000 1.000

1203287000 12C Plum, prune, dried 0.050000 5.000 1.000

1203287001 12C Plum, prune, dried

- babyfood 0.050000 5.000 1.000

1203286000 12C Plum, p rune, fresh 0.050000 1.000 1.000

1203286001 12C Plum, prune, fresh

- babyfood 0.050000 1.000 1.000

1203288000 12C Plum, prune, juice 0.050000 1.400 1.000

1203288001 12C Plum, prune, juice

- babyfood 0.050000 1.400 1.000

1203285001 12C Plum

- babyfood 0.050000 1.000 1.000

1304175000 13D Grape 0.050000 1.000 0.025

1304176000 13D Grape, juice 0.050000 1.200 0.02 5

1304176001 13D Grape, juice

- babyfood 0.050000 1.200 0.025

1304179000 13D Grape, wine and sherry 0.050000 1.000 0.025

1400003000 14 Almond 0.050000 1.000 0.010

1400004000 14 Almon d, oil 0.050000 1.000 0.010

1400004001 14 Almond, oil

- babyfood 0.050000 1.000 0.010

1400003001 14 Almond

- babyfood 0.050000 1.000 0.010

1400059000 14 Brazil nut 0.050000 1.000 1.000

1400068000 14 Butternut 0.050000 1.000 1.000

1400081000 14 Cashew 0.050000 1.000 1.000

1400092000 14 Chestnut 0.050000 1.000 1.000

1400155000 14 Hazelnut 0.050000 1.000 1.000

1400156000 14 Hazelnut, oil 0.050000 1.000 1.000

1400185000 14 Hickory nut 0.050000 1.000 1.000

1400213000 14 Macadamia nut 0.050000 1.000 1.000

1400269000 14 Pecan 0.050000 1.000 0.010

1400278000 14 Pine nut 0.050000 1.000 1.000

1400282000 14 Pistachio 0.050000 1.000 0.025

1400391000 14 Walnut 0.050000 1.000 0.010

1500027000 15 Barley, bran 0.050000 1.000 0.010

1500026000 15 Barley, flour 0.050000 1.000 0.010

1500026001 15 Barley, flour

- babyfood 0.050000 1.000 0.010

1500025000 15 Barley, pearled barley 0.050000 1.000 0.010

1500025001 15 Barley, pearled barley

- babyfood 0.050000 1.000 0.010

1500122000 15 Corn, field, bran 0.050000 1.000 0.010

1500120000 15 Corn, field, flour 0.050000 1.000 0.010

1500120001 15 Corn, field, flour

- babyfood 0.050000 1.000 0.01 0

1500121000 15 Corn, field, meal 0.050000 1.000 0.010

1500121001 15 Corn, field, meal

- babyfood 0.050000 1.000 0.010

1500125000 15 Corn, field, oil 0.050000 1.000 0.010

1500125001 15 Corn, field, oil

- babyfood 0.050000 1.000 0.010

1500123000 15 Corn, field, starch 0.050000 1.000 0.010

1500123001 15 Corn, field, starch

- babyfood 0.050000 1.000 0.010

1500124000 15 Corn, field, syrup 0.050000 1.500 0.010

1500124001 15 Corn, field, syrup

- babyfood 0.050000 1.500 0.010

1500344000 15 Sorghum, grain 0.050000 1.000 0.010

1500345000 15 Sorghum, syrup 0.050000 1.000 0.010

1500401000 15 Wheat, grain 0.050000 1.000 0.010

1500401001 15 Wheat, grain

- babyfood 0.050000 1.000 0.010

2003114001 20C Coconut, oil

- babyfood 0.050000 1.000 1.000Trifluralin Dietary Exposure and Risk Assessment DP Number: 4 10618

Page 25 of 27 2003128000 20C Cottonseed, oil 0.050000 1.000 0.300

2003128001 20C Cottonseed, oil

- babyfood 0.050000 1.000 0.300

2001163000 20A Flax seed, oil 0.050000 1.000 1.000

2001319000 20A Rapeseed, oil 0.050000 1.000 0.025

2001319001 20A Rapeseed, oil

- babyfood 0.050000 1.000 0.025

2002330000 20B Safflower, oil 0.050000 1.000 1.000

2002330001 20B Safflower, oil

- babyfood 0.050000 1.000 1.000

2001337000 20A Sesame, oil 0.050000 1.000 1.000

2001337001 20A Sesame, oil

- babyfood 0.050000 1.000 1.000

2001336000 20A Sesame, seed 0.050000 1.000 1.000

2001336001 20A Sesame, seed

- babyfood 0.050000 1.000 1.000

2002365000 20B Sunflower, oil 0.050000 1.000 0.100

2002365001 20B Sunflower, oil

- babyfood 0.050000 1.000 0.100

2002364000 20B Sunflower, seed 0.050000 1.000 0.100

8601000000 86A Water, direct, all sources 0.001590 1.000 1.000 30 yr

Full comment: 30 yr avg

8602000000 86B Water, indirect , all sources 0.001590 1.000 1.000 30 yr

Full comment: 30 yr avg



### Attachment 4 : C ancer Food plus Water Results

US EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID Chronic analysis for TRIFLURALIN NHANES 2003

- 2008 2

- day

Residue file name: C: \ Documents and

Settings \ spiper \ Desktop \ Trifluralin \ Dietary \ Trifluralin_cancer_refined.r08

Adjustment factor #2 used.

Analysis Date 01

- 31

- 2013/16:14:39 Residue file dated: 01

- 31

- 2013/16:13:57

Q* = 0.00296

COMMENT 1: Cancer

===============================================================================

Total exposure by population subgroup

---------------------- ---------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Lifetime risk

Subgroup body wt/day (Q*= .00296)

-------------------------------------- ------------- -------------- Total US Population 0.000070 2.07E

- 07

Hispanic 0.000070 2.06E

- 07

Non

- Hisp

- White 0.000070 2.07E

- 07

Non

- Hisp

- Black 0.000064 1.90E

- 07

Non

- Hisp

- Other 0.000084 2.47 E

- 07

Nursing Infants 0.000108 3.20E

- 07

Non

- Nursing Infants 0.000231 6.83E

- 07

Female 13+ PREG 0.000067 1.97E

- 07

Children 1

- 6 0.000126 3.73E

- 07

Children 7

- 12 0.000070 2.08E

- 07

Male 13

- 19 0.000048 1.42E

- 07

Female 13

- 19/NP 0.000051 1.50E

- 07

Male 20+ 0.000060 1.78E

- 07

Female 20+/NP 0.000067 1.98E

- 07

Seniors 55+ 0.000066 1.96E

- 07

All Infants 0.000193 5. 71E

- 07

Female 13

- 50 0.000062 1.84E

- 07

Children 1

- 2 0.000147 4.34E

- 07

Children 3

- 5 0.000119 3.52E

- 07

Children 6

- 12 0.000075 2.22E

- 07

Youth 13

- 19 0.000049 1.46E

- 07

Adults 20

- 49 0.000062 1.83E

- 07

Adults 50

- 99 0.000066 1.96E

- 07

Female 13

- 49 0.000062 1.83E

- 07Trifluralin Dietary Exposure and Risk Assessment DP Number: 4 10618

Page 26 of 27 -------------------------------------------------------------------------------



### Attachment 5: Trifluralin Screening Level Usage Analysis (SLUA)

December 7, 2012

Screening Level Estimates of Agricultural Uses of Trifluralin ( 036101 )

Sorted Alphabetically

Reporting Years: 2004

- 201 1

Percent Crop T reated

Crop Lbs. A.I. Avg. Max.

1 Alfalfa 400,000 <2.5 <2.5

2 Almonds 7,000 <1 <2.5

3 Apples <500 <1 <2.5

4 Apricots * <500 NC NC

5 Asparagus 10,000 20 30

6 Barley 4,000 <1 <2.5

7 Beans, Green 40,000 25 35

8 Broccoli 6,000 10 25

9 Brussels Sprouts * <500 NC NC

10 Cabbage 20,000 40 60

11 Canola 9,000 <2.5 <2.5

12 Cantaloupes 10,000 25 45

13 Carrots 30,000 40 65

14 Cauliflower 2,000 10 20

15 Celery <500 <2.5 5

16 Chicory * <500 NC NC

17 Corn 80,000 <1 <2.5

18 Cotton 3,200,000 30 35

19 Cucumbers 3,000 <2.5 10

20 Dry Beans/Peas 200,000 10 20

21 Fallow 40,000 <1 <2.5

22 Garlic 1,000 5 10

23 Grapefruit 1,000 <1 <2.5

24 Grapes 20,000 <2.5 <2.5

25 Honeydews 3,000 20 35

26 Lemons <500 <1 <2.5

27 Lettuce 4,000 <2.5 <2.5

28 Nectarines * <500 NC NC

29 Onions 1,000 <2.5 5Trifluralin Dietary Exposure and Risk Assessment DP Number: 4 10618

Page 27 of 27 

### 30 Oranges 10,000 <1 <2.5

31 Peaches <500 <1 <2.5

32 Peanuts 30,000 5 10

33 Peas, Green 9,000 10 20

34 Pecans 2,000 <1 <2.5

35 Peppers 10,000 25 40

36 Pistachios 1,000 <2.5 <2.5

37 Plums/Prunes * <500 NC NC

38 Potatoes 10,000 <2.5 5

39 Pumpkins 3,000 5 10

40 Sorghum 30,000 <1 <2.5

41 Soybeans 1,700,000 5 10

42 Spinach <500 <1 <2.5

43 Squash 1,000 5 10

44 Strawberries <500 <1 <2.5

45 Sugar Beets 10,000 <2.5 5

46 Sugarcane 100,000 5 10

47 Sunflowers 200,000 10 20

48 Sweet Corn 1,000 <1 <2.5

49 Tobacco+ 1,000 <1 <2.5

50 Tomatoes 100,000 60 70

51 Walnuts 2,000 <1 <2.5

52 Watermelons 20,000 10 20

53 Wheat 60,000 <1 <2.5

All numbers are rounded.

<500 : indicates less than 500 pounds of active ingredient.

<2.5 : indicates less than 2.5 percent of crop is treated.

<1 : indicates less than 1 percent of crop is treated.

* Based on CA DPR data only (80% or more of U.S. acres grown are in California)

NC: not calculated, only pounds a.i. available.

+ Crops not known to be listed on active end use product registrations or as Section 18 emergency exemptions when this

report was run

SLUA data sources include:

USDA

- NASS (United States Department of Agriculture's National Agricultural Statistics Service)

Private Pesticide Market Research

California DPR (Department of Pesticide Regulation)

These results reflect amalgamated data developed by the Agency and are releasable to the public.