## FINAL **REPORT**

Contents : Volume 1 of 4 Text , S ummary Tables, and Appendices A - F

Study Title : An Inhalation Reproduction/Developmental Toxicity

Screening Study

of 2

- Bromo -3,3,3

- Triflu oropropene in Rats

Laboratory

Project ID : WI L-65501

Author: Tammy e L. Edwards, BS

Test Guideline : OECD Guideline 421

Study Completion Date : 21 March 2014

Performing Laboratory : WI L Research 1407 George Road Ashland, OH 44805

- 8946

Sponsor : American Pacific Corporation 3883 Howard Hughes Parkway , Suite 700 Las Vegas, NV 89169

Total Number of Pages : 1 107

**Page 1 of 1107**

## WIL-65501 American Pacific Corporation



# COMPLIANCE STATEMENT

The following is a detailed descriptio n of all differences betwe en the pr actices used in this study,

WIL-65501, and those required by the United States EPA GLP Standards 40 CFR Part 792
(1 

## 8 

## September 1989); the OECD Principles of GLP [C(97) 186/Final] (26 November 1997); WIL

Research’s SOPS; 

## and the study protocol as approved by the Sponsor:

A Certificate of Analysis for the test substance was provided by the Sponsor (presented in Appendix B); the characterization analyses were not compliant with

GLP standards.

This protocol was designed in general accordance with the OECD Guidelines for the Testing of
Chemicals, Guideline 42 I, ReproductiodDevelopmental 

## Toxicity Screening Test, 27 July 1995.

Typed Name of Signer: Tarnmye L. Edwards, BS

Typed Name of 

## Laboratory: WIL Research

Sponsor: Signature

Typed Name of Signer: Bradford Colton

Typed Name of Company: American Pacific Corporation Date

Submitter: Signature Date

Typed Name of 

## Signer:

Typed Name of 

## Company:

Page 2 

## of 

## 1107

## WI L-65501 2

- Bromo -3,3,3- Trifluoropropene

American Pacific Corporation



# T **ABLE O**  **F** 

# C **ONTENTS**



## VOLUME 1 Page

**Compliance Statement**

**................................ ................................**  **............... 2** 

**Table of Contents**

**................................ ................................**  **....................... 3** 

**Index of Tables**

**................................ ................................**  **........................... 7** 

**I ndex of Appendices** 

**................................ ................................**  **................. 10** 

**1**

**. Summary** 

**................................ ................................**  **................................ ...**  **14**

1.1

. Objective

................................ ................................ ................................ .... 14

1.2

. Study

Design

................................ ................................ .............................. 14

1.3

. Results

................................ ................................ ................................ ........ 15

1.4

. Conclusion

................................ ................................ ................................ . 18

**2 . Introduction................................** 

**................................ ..............................**  **20**

2.1

. General Study

I nformation

................................ ................................ ........ 20

2.2

. Key Study Dates

................................ ................................ ........................ 20

2.3

. Participating Scientists

................................ ................................ ............... 21

2.4

. Contributing Scientists and Test Sites

................................ ....................... 21

2.5

. Principal I nvestigators and Test Sites

................................ ........................ 21

2.6

. WI L Research Key

Study Personnel

................................ .......................... 21

**3**

**. Study Design** 

**................................ ................................**  **............................. 22** 

**4**

**. Experimental Procedures**  **- Materials and Met hods** 

**............................. 24** 

4.1

. Test Substance and Control Substance

................................ ...................... 24

4.1.1

. Test Substance

................................ ................................ ........................... 24

4.1.2

. Control Substance

................................ ................................ ...................... 24

4.2

. Exposure Methods

................................ ................................ ..................... 25

4.3

. Test Atmosphere Generation Methods

................................ ...................... 25

4.3.1

. Exposure Chambers 2, 3, and 4

................................ ................................ . 25

4.3.2 . Exposure Chamber 5B (10,000 ppm) ................................

........................ 27

4.4

. Me thods for Characterization of Exposure Atmospheres

.......................... 27

4.4.1

. Nominal Concentrations

................................ ................................ ............ 27

**Page 3 of 1107**

## WI L-65501 2

- Bromo -3,3,3- Trifluoropropene

American Pacific Corporation

**VOLUME 1 (continued)** Page

4.4.2

. Analy zed Exposure Concentrations

................................ ........................... 28

4.5

. Test Sy stem, Animal Receipt, and Acclimation Period

............................. 28

4.6

. Animal Housing (Non

- Exposure Periods)

................................ ................. 29

4.7

. Diet, Drinking Water, and Maintenance

................................ .................... 30

4.8

. En vironmental Conditions (Non

- Exposure Periods)

................................ . 30

4.9

. Assignment of Animals to Treatment Groups

................................ ........... 31

4.10

. Organization of Test Groups, Dosage Levels, and Treatment Regimen

................................ ................................ ................................ ..... 31

**5**

**. Parameters Evaluated** 

**................................ ................................**  **............. 34** 

5.1 . Clinical Observations and Survival ................................

........................... 34

5.2

. Bod y Weights

................................ ................................ ............................. 34

5.3

. Food Consumption

................................ ................................ ..................... 35

5.4

. Water Consumption

................................ ................................ ................... 35

5.5

. Estrous Cy cles

................................ ................................ ............................ 35

5.6

. Breeding Procedures

................................ ................................ .................. 36

5.7

. Parturition

................................ ................................ ................................ .. 37

5.8

. Spermatogenic Endpoint Evaluations

................................ ........................ 37

5.9

. Anatomic Pathology

................................ ................................ ................... 38

5.9.1

. Macroscopic Examination

................................ ................................ ......... 38

5.9.2

. Organ Weights

................................ ................................ ........................... 39

5.9.3

. Histology

and Microscopic Examination s................................................. 40

5.10 . F 1 

## Li tter Parameters

................................ ................................ ................... 40

5.10.1

. Litter Viability and Deaths

................................ ......................................... 40

5.10.2

. Clinical Observations

................................ ................................ ................. 41

5.10.3

. Bod y Weights

................................ ................................ ............................. 41

5.10.4

. Sex Determination

................................ ................................ ..................... 41

5.10.5

. Calculation of L itter Parameters

................................ ................................ 42

5.10.6

. Scheduled Euthanasia

................................ ................................ ................ 42

5.11

. Data Acquisition and A naly sis

................................ ................................ ... 42

**Page 4 of 1107**

## WI L-65501 2

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American Pacific Corporation

**VOLUME 1 (continued)** Page

5.11.1 . Acquisition and Reporting ................................

................................ ......... 42

5.11.2

. Statistical Analy ses

................................ ................................ .................... 43

**6**

**. Results** 

**................................ ................................**  **................................ .......**  **45**

6 .1

. Analy zed Exposure Concentrations

................................ ........................... 45

6.2 . F 0 

## Generation

................................ ................................ ............................. 45

6.2.1 . Clinical Observations and Survival ................................

........................... 45

6.2.2

. Bod y Weights

................................ ................................ ............................. 46

6. 2.2.1

. Males

................................ ................................ ................................ .......... 46

6.2.2.2

. Females

................................ ................................ ................................ ...... 47

6.2.2.2.1

. Pre

- Mating

................................ ................................ ................................ 47

6.2.2.2.2

. Gestation

................................ ................................ ................................ ... 47

6.2.2.2.3

. Lactation

................................ ................................ ................................ ... 48

6.2.3

. Food Consumption

................................ ................................ ..................... 48

6.2.3.1

. Males

................................ ................................ ................................ .......... 48

6.2.3.2

. Females

................................ ................................ ................................ ...... 49

6.2.3.2.1

. Pre

- Mating

................................ ................................ ................................ 49

6.2.3.2.2

. Gestation

................................ ................................ ................................ ... 49

6.2.3.2.3

. Lactation

................................ ................................ ................................ ... 50

6.2.4

. Water Consumption

................................ ................................ ................... 50

6.2.4.1

. Males

................................ ................................ ................................ .......... 50

6.2.4.2

. Females

................................ ................................ ................................ ...... 50

6.2.4.2.1

. Pre

- Mating

................................ ................................ ................................ 50

6.2.4.2.2

. Gestation

................................ ................................ ................................ ... 51

6.2.4.2.3

. Lactation

................................ ................................ ................................ ... 51

6.2.5

. Reproductive Performance

................................ ................................ ......... 52

6.2.6

. Gestation Length and Parturition

................................ ............................... 53

6.2.7

. Spermatogenic Endpoint Evaluations

................................ ........................ 53

6.2.8

. Anatomic Pathology

................................ ................................ ................... 54

6.2.8.1

. Macroscopic Examinations

................................ ................................ ........ 54

**Page 5 of 1107**

## WI L-65501 2

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**VOLUME 1 (continued)** Page

6.2.8.2

. Organ Weights

................................ ................................ ........................... 54

6.2.8.3 . Microscopic Examinations................................

................................ ......... 55

6.3 . F 1 

## Li tter Data

................................ ................................ .............................. 56

6.3.1

. PND 0 L itter Data and Postnatal Survival

................................ ................. 56

6.3.2

. General Phy sical Condition

................................ ................................ ....... 57

6.3.3

. Offspring Bod y Weights

................................ ................................ ............ 57

6.3.4

. Necropsies of Pups Found Dead

................................ ................................ 58

**7**

**. Discussion** 

**................................ ................................**  **................................ ..**  **59**

**8**

**. Conclusions** 

**................................ ................................**  **............................... 62** 

**9 . Report Review and Approval ................................** 

**................................ .**  **63**

**10**

**. Quality Assurance Statement** 

**................................ ................................**  **.. 64** 

**11**

**. References** 

**................................ ................................**  **................................ .**  **67**

**12**

**. Data Reten**  **tion**

**................................ ................................**  **.......................... 69** 

**13**

**. Abbreviations** 

**................................ ................................**  **........................... 70** 

**Page 6 of 1107**

## WI L-65501 2

- Bromo -3,3,3- Trifluoropropene

American Pacific Corporation



# I **NDEX O**  **F** 

# T **AB LES**  

## VOLUME 1 (continued) Page



# S **UMMARY** 

# D **ATA** 

# - F **0** 

# G **ENERATION**



## S1. Summary

of Clinical Findings (F 0 

## Males

- Detailed Physical Examinations)

.......... 72

S2. Summary

of Clinical Findings (F 0 

## Males

- 15 Minutes Post

- Exposure

- Group 5)

.................................................... 73

S3. Summary

of Clinical Findings (F 0 

## Males

- 1 Hour Post

- Exposure

- Group 5)

......... 75

S4. Summary

of Clinical Findings (F 0 

## Males

- 1 Hour Following 6

- Hour Exposure Period)

.......................................... 76

S5. Summary

of Clinical Findings (F 0 

## Females

- Detailed Physical Examinations)

......................................................... 77

S6. Summary

of Clinical Findings (F 0 

## Females

- 15 Minutes Post

- Ex posure

- Group 5)

................................................. 78

S7. Summary

of Clinical Fin dings (F 0 

## Females

- 1 Hour Post

- Exposure

- Group 5)

........................................................ 80

S8. Summary

of Clinical Findings (F 0 

## Females

- 1 Hour Followi ng 6

- Hour Exposure Period)

....................................... 81

S9. Summary

of Body Weights [g] (F 0 

## Males)

................................ ................................ 82

S10. Summary

of Body Weight Changes [g] (F 0 

## Males)

................................................... 83

S11. Summary

of Body We ights [g] (F 0 

## Females)

............................................................. 85

S12. Summary

of Body Weight Changes [g] (F 0 

## Females)

............................................... 86

S13. Summary

of Body Weights during Gestation [g] (F 0 

## Females)

................................ . 87

S14. Summary

of Body Weig ht Changes during Gestation [g] (F 0 

## Females)

................... 89

S15. Summary

of Body Weights during Lactation [g] (F 0 

## Females)

................................ . 91

S16. Summary

of Body Weight Changes during Lactation [g] (F 0 

## Females)

................... 92

S17. Summary

of Food Consumption [g/animal/day ] (F 0 

## Males)

..................................... 93

**Page 7 of 1107**

## WI L-65501 2

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American Pacific Corporation

**VOLUME 1 (continued)** Page

S18. Summary

of Food Consumption [g/kg/day ] (F 0 

## Males)

............................................ 94

S19. Summary

of Food Consumption [g/animal/day ] (F 0 

## Females)

.................................. 95

S20. Summary

of Food Consumption [g/kg/day ] (F 0 

## Females)

......................................... 96

S21. Summary

of Food Consumption during Gestation [g/animal/day ] (F 0 

## Females)

................................ ................................ ................................................ 97

S22. Summa

ry of Food Consumption during Gestation [g/kg/day ] (F 0 

## Females)

............ 99

S23. Summary

of Food Consumption during Lactation [g/ani mal/day ] (F 0 

## Females)

................................ ............................................................... ............... 101

S24. Summary

of Food Consumption during Lactation [g/kg/day ] (F 0 

## Females)

........... 102

S25. Summary

of Water Consumption [g/animal/day ] (F 0 

## Males)

.................................. 103

S26. Summary

of Water Consumption [g/kg/day ] (F 0 

## Males)

......................................... 104

S27. Summary

of Water Consumption [ g/animal/day ] (F 0 

## Females)

.............................. 105

S28. Summary

of Water Consumption [g/kg/day ] (F 0 

## Females)

..................................... 106

S29. Summary

of Water Consumption during Gestation [g/animal/day ] (F 0 

## Females)

................................ ............................................................... ............... 107

S30. Summary

of Water Consumption during Gestation [g/kg/day ] (F 0 

## Females)

......... 109

S3 1. Summary

of Water Consumption during Lactation [g/animal/day ] (F 0 

## Females)

................................ ............................................................... ............... 111

S32. Summary

of Water Consumption du ring Lactation [g/kg/day ] (F 0 

## Females)

......... 112

S33. Summary

of Estrous Cy

cle Data (F 0 

## Females)

........................................................ 113

S34. Summary

of Reproductive Performance (F 0 

## )

........................................................... 114

S35. Summary

of Gesta tion Lengths [day s] (F 0 

## Females)

............................................... 117

S36. Summary

of Parturition Findings: Total Occurrence/No. of Females (F 0 

## Females)

................................ ............................................................... ............... 118

S37. Summary

of Sperm Motility

and Concentration (F 0 

## Males)

.................................... 119

**Page 8 of 1107**

## WI L-65501 2

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American Pacific Corporation

**VOLUME 1 (continued)** Page

S38. Summary

of Sperm Morphology

Differential Count [percentage] (F 0 

## Males)

....... 121

S39. Summary

of Macroscopic Findings (F 0 

## Males)

....................................................... 123

S40. Summary

of Macroscopic Findings (F 0 

## Females

- Failed to Deliver)

..................... 124

S41. Summary

of Macroscopic Findings (F 0 

## Females

- Total Litter Loss)

..................... 125

S42

. Summary

of Macroscopic Findings (F 0 

## Females

- Lactation Day 4) ...................... 126

S43

. Summary

of Corpora L

utea and I mplantation Sites (F 0 

## Females)

........................... 127

S44

. Summary

of Organ Weig hts and Relative Organ Weights (F 0 

## Males)

.................... 128

S45

. Summary

of Organ Weights and Relative Organ Weights (F 0 

## Females

- Lactation D ay 4) ................................................................................ 137

S46

. Summary

of Microscopic Findings (F 0 

## Males)

........................................................ 143

S47. Summary

of Microscopic Findings (F 0 

## Females

- Failed to Deliver)

..................... 146

S48. Summary

of Microscopic Findings (F 0 

## Females

- Total Litter Loss)

...................... 148

S49

. Summary

of Microscopic Findings (F 0 

## Femal es

- La ctation Day 4)....................... 150

S50

. Summary

of Primordial Follicle Counts (F 0 

## Females)

............................................ 152



# S **UMMARY** 

# D **ATA** 

# - F **1** 

# L **ITTERS**



## S51

. Summary

of PND 0 L itter Data (F 1 

## )

............................................................... ......... 153

S52

. Summ ary

of Postnatal Survival [% per litter] (F 1 

## )

................................................... 154

S53

. Summary

of Clinical Findings: Total Occurrence/No. of Pups (F 1 

## )

....................... 155

S54

. Summary

of Offspring Weights [g] (F 1 

## )

............................................................... ... 15 7

S55

. Summary

of Offspring Weight Changes [g] (F 1 

## )

..................................................... 158

S56

. Summary

of Pup Necropsy Findings (F 1 

## - Unscheduled Deaths)

........................... 159

**Page 9 of 1107**

## WI L-65501 2

- Bromo -3,3,3- Trifluoropropene

American Pacific Corporation



# I **NDEX O**  **F** 

# A **PPENDICES**



## VOLUME 1 **(continued)** Page

A. Study Protocol and Deviations

............................................................... .................. 160

B. Certificate o f Analy sis ( Sponsor

- Provided Data)

.................................................... 200

C. E xposure Atmosphere Generation Report ( WIL Research )

.................................... 203

D. Animal Room Environmental Condit ions

............................................................... . 26 9

E. Pathology

Report ( WIL Research )

............................................................... ............ 2 76

F. WIL Research Reproductive Historical Control Data [Crl:CD(SD) Rats]

.............. 2 88

**VOLUME 2**

G. Individual Animal Data

............................................................... ............................. 29 9



# F **0** 

# G **ENERATION**



## A1. In dividual Clinical Observations (F 0 

## Males

- Detailed Phy si cal Examinations)

.................................................. 300

A2. In dividual Clinical Observations (F 0 

## Males

- 15 Minutes Post

- Exposure

- Group 5)

.......................................... 3 15

A3. In dividual Clinical Observations (F 0 

## Males

- 1 Hour Post

- Exposure

- Group 5)

................................................. 3 34

A4. In dividual Clinical Observations (F 0 

## Males

- 1 Hour Following 6

- Hour Exposure Period)

................................ 3 47

A5. In dividual Clinical Observations (F 0 

## Females

- Detailed Phy sical Examinations)

............................................... 407

A6. In dividual Clinical Observations (F 0 

## Females

- 15 Minutes Post

- Ex posure

- Group 5)

....................................... 4 27

A7. In dividual Clinical Observations (F 0 

## Females

- 1 Hour Post

- Exposure

- Group 5)

.............................................. 44 9

A8. In dividual Clinical Observations (F 0 

## Females

- 1 Hour Following 6

- Hour Exposure Period )

............................. 4 66

**Page 10 of 1107**

## WI L-65501 2

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American Pacific Corporation

**VOLUME 2 (continued)** Page

A9. In dividual Body

Weights [g ] (F 0 

## Males)

.......................................................... 5 43

A10. In divid

ual Body Weight Changes [g] (F 0 

## Males)

.......................................... 5 48

A11. In dividual Body

Weights [g] (F 0 

## Females)

.................................................... 5 53

A12. In dividual Body

Weight Changes [g] (F 0 

## Females)

....................................... 5 58

A13. In dividual Body

Weights during Ge station [g] (F 0 

## Females)

........................ 5 63

A14. In dividual Body

Weight Changes during Gestation [g] (F 0 

## Females)

........... 5 68

A15. In dividual Body

Weights during Lactation [g] (F 0 

## Females)

........................ 5 73

A16. In dividual Body

Weight Changes during Lactation [g] (F 0 

## Females)

........... 5 78

A17. In dividual Food Consu mption [g/animal/day ] (F 0 

## Males)

............................. 5 83

A18. In dividual Food Consumption [g/kg/day ] (F 0 

## Males)

.................................... 5 88

**VOLUME 3**

A19. In dividual Food Consumption [g/animal/day ] (F 0 

## Females)

......................... 5 95

A20. In dividual Food Consumption [g/kg/day ] (F 0 

## Females)

................................ 600

A21. In dividual Food Consumption during Gestation [g/animal /day ] (F 0 

## Females)

................................ ............................................................... ..... 605

A22. In dividual Food Consumption during Gestation [g/kg/day ] (F 0 

## Fema les)

................................ ............................................................... ..... 6 10

A23. In dividual Food Consumption during Lactation [g/animal/day ] (F 0 

## Females)

................................ ............................................................... ..... 6 15

A24. In dividual Food Consumption during Lactation [g/kg/day ] (F 0 

## Females)

................................ ............................................................... ..... 6 20

A25. In dividual Water Consumption [g/animal/day] (F 0 

## Males)

........................... 6 25

A26. In dividual Water Consumption [g/kg/day ] (F 0 

## Males)

.................................. 6 35

A27. In dividual Water Consumption [g/animal/day ] (F 0 

## Females)

........................ 6 40

**Page 11 of 1107**

## WI L-65501 2

- Bromo -3,3,3- Trifluoropropene

American Pacific Corporation

**VOLUME 3 (continued)** Page

A28. In dividual Water Consumption [g/kg/day ] (F 0 

## Females)

............................... 6 60

A29. In dividual Water Consumption during Gestation [g/animal/day ] (F 0 

## Females)

................................ ............................................................... ..... 6 65

A30. In dividual Water Consumption during Gestation [g/kg/day ] (F 0 

## Females)

................................ ............................................................... ..... 6 85

A31. In dividual Water Consumption during Lactation [g/animal/day ] (F 0 

## Females)

................................ ............................................................... ..... 6 90

A32. In dividual Water Consumption during Lactation [g/kg/day ] (F 0 

## Females)

................................ ............................................................... ..... 6 95

A33. In dividual Estrous Cy cle Data (F 0 

## Females)

.................................................. 700

A34. In dividual Reproductive Performance (F 0 

## )

.................................................... 705

A35. In dividual Gestation Lengths [day s] (F 0 

## Females)

......................................... 7 10

A36. In dividual Dam Observations during Parturition (F 0 

## Females)

..................... 7 11

A37. In dividual Sperm Motility and Concentration (F 0 

## Males)

............................. 7 27

A38. I ndividual Sperm Morphology Differential Count [percentage] (F 0 

## Males)

................................ ............................................................... ....... 7 32

A39. In dividual Macroscopic and Microscopic Findings (F 0 

## Males)

..................... 7 37

A40. In dividual Macroscopic and Microscopic Findings (F 0 

## Females

- Failed to Deliver)

............................................................... ...... 79 9

A41. I ndividual Macroscopic and Microscopic Findings (F 0 

## Females

- Total Litter Loss)

............................................................... ...... 800

**VOLUME 4**

A42

. In dividual Macroscopic and Microscopic Findings (F 0 

## Females

- Lactation Day 4) ...................................................................... 803

A43

. In dividual Corpora Lutea and Im plantation Sites (F 0 

## Females)

.................... 8 61

A44

. In dividual Organ Weig hts and Final Body Weights [g] (F 0 

## Males)

.............. 8 66

**Page 12 of 1107**

## WI L-65501 2

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American Pacific Corporation

**VOLUME 4 (continued)** Page

A45

. In dividual Organ Wts. Relative to Final Body Wt s. [g/100 g] (F 0 

## Males)

................................ ............................................................... ........ 8 76

A46 . I ndividual Organ Weights Relative to Brain Weights [g/100 g] (F 0 

## Males)

................................ ............................................................... ........ 8 86

A47

. In dividual Organ Weights and Final Body Weights [g] (F 0 

## Females

- Lactation Day 4) ...................................................................... 8 96

A48

. In dividual Organ Wts. Relative to Final Body Wts. [g/100 g] (F 0 

## Females

- Lactation Day 4) ...................................................................... 901

A49

. In dividual Organ Weights Relative to Brain Weights [g/100 g] (F 0 

## Fem ales

- Lactati on Day 4) ...................................................................... 906

A50

. In dividual Ovarian Primordial Follicle Counts (F 0 

## Females)

........................ 9 11



# F **1** 

# L **ITTER** 

# G **ENERATION**



## A51

. In dividual L itter Viability (F 1 

## )

............................................................... ........ 9 14

A52

. In dividual Pup Viability (F 1 

## )

............................................................... ........... 9 24

A 53. In dividual Postnatal Survival (% per Litter) (F 1 

## )

........................................... 9 34

A54

. In dividual Pup Clinical Observations (F 1 

## )

..................................................... 93 9

A55

. In dividual Offspring We ights [g] (F 1 

## )

.......................................................... 1018

A56

. In dividual Offspring Weight Changes [g] (F 1 

## )

............................................ 1060

A57

. In dividual Pup Necropsy Findings (F 1 

## - Unscheduled Deaths)

................... 1 100

**Page 13 of 1107**

## WI L-65501 2

- Bromo -3,3,3- Trifluoropropene

American Pacific Corporation



# 1. S **UMMAR**

**Y**


# 1.1. **O BJECTIVE**  

## This study

wa s designed to provide information on the potential adverse effects of the test

substance on male and female reproduction within the scope of a screening study

. T his
encompassed gonadal function, mating behavior, conception, parturition, and lactation of

t he F 0 

## generation and the development of offspring from conception through day 4 o f
postnatal life. The test substance is currently i ntended for use as a fire extinguishing

agent and a special acute exposure group was included in the study t o mimic the

maximum ex posure to the test substance as discharged from a fire extinguisher in all
known environments where clean agents are used, including aviation

.



# 1.2. **S TUDY**  

# D **ESIGN**



## The test substance , 2

- Bromo -3,3,3

- Trifluoropropene

, was administered via whole- body

inhalat ion exposure for 6 hours per day to 3 groups (Groups 2

- 4) and for 5 minutes per day t o 1 group (Group 5) of Crl:CD(SD) rats ; animals in Group 5 were exposed to

filtered air for the remainder of the 6

- hour exposure period. E ach group consisted of

12 males and 12 females. Target exposure concentrations were 50, 100, 175, and
10,000 ppm. A c oncurrent control group of 12 rats/sex was exposed to filtered air for

6 hours per day

. Males and females were approximately 10 weeks of age at the
beginning of test su bstance exposure

. Males were exposed to the test substance for

14 day s prior to mating and throughout the mating period until 1 day p rior to euthanasia

for a total of 28-29 days of exposure

. F emales were exposed to the test substance for

14 day s prior to pairing and throughout the mating period until gestation day 2 0 for a
total of 35 -46 d ay s of exposure ; females that failed to deliver were dosed through the day
prior to euthanasia (post- cohabitation day 2 5 ) for a total of 52 day s of exposure

. All

animal s were observed twice daily f or mortality

a nd moribundity

. C linical observations,
body w eights

, and food and water consumption were recorded at appropriate intervals.

All F 0 

## females were allowed to deliver and rear their pups until lactation day 4

. F 1 

## c linical observations and body w eights were recorded on PND 1 and 4. P ups were
euthanized on PND 4. F 0 

## males were euthanized following completion of the mating
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period and F 0 

## females were euthanized on lactation day 4

. Spermatogenic endpoint

evaluations w ere conducted on all F 0 

## males. Complete necropsies were conducted on all

F 0 

## animals, and selected organs were weighed. S elected tissues were examined
microscopicall y from all F 0 

## anim als in the control, 175, and 10,000 ppm groups.



# 1.3. **R ESULTS** 



## There were no ef

fects on F 0 

## parental survival at an y exposure concentration. T est

substance -related clinical findings noted at 15 minutes following exposure for males and

females in the 10,000 ppm group included hy poacti vity

, decreased respiration,
completely

s hut ey elid s , and lacrimation

. H owever, these findings were only n oted on
the first day

o f exposure (study

d ay 0 ) and were resolved by 1 h our following exposure.

In addition, salivation and red and/or clear material around the mouth and/or nose were
noted for males and females in the 10,000 ppm group throughout the respective exposure periods at 15 minutes and/or 1 hour followi ng exposure. N o other test substance

- related

clinical findings were noted for males or females in the 50, 100, 175, and 10,000 ppm

groups

. At the scheduled necrops y, no noteworthy m acroscopic findings were noted for

F 0 

## males and females at any exposure concentration.

In the 10,000 ppm group F 0 

## males, lower mean body weight gains were noted throughout

the exposure period and resulted in a lowe r mean body w eight on study day 28. I n addition, corresponding lower mean food consumption was noted for the 10,000 ppm

group males compared to the control group during the pre

- ma ting period (study
day s 0- 13). T he aforementioned body w eight and food cons umption effects for F 0 

## males

were considered test substance -related and adverse within the context of a toxicology
study

. H owever, given that the 10,000 ppm exposure level was intended to mimic and

assess a single maximum exposure in humans analogous to t hat which might occur during fire fighter usage , the changes noted in mean body w eight gain and food
consumption that led to a reduction in mean body w eight onl y after 28 day s of exposure
would not be relevant to a single exposure scenario at the same expo sure level. Mean body w eights, body

w eight gains, and food consumption in the 10,000 ppm group

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F 0 

## females were generally s imilar to the control group during the pre

- mating period,
gestation, and lactation. In a ddition, mean water consumption for F 0 

## males and females
at 10,000 ppm was unaffected b y test substance exposure.

Mean body

w eight gains for F 0 

## males in the 100 and 175 ppm groups were similar to the

control group during the pre

- mating period (study d ay s 0

- 13), but lower mean body
weight gains were noted in these groups compared to the control group during study
day s 21-28. H owever, the aforementioned changes for F 0 

## males at 100 and 175 ppm

were not of sufficient magnitude to a ffect mean body w eights in these groups, and

therefore were considered te st substance

- related but non adverse. Mean body weight s and
body w eight gain s at 50 ppm, and mean food and water consumption at 50, 100, and 175

ppm were similar to the control group during the exposure period.

Mean body weights, body w eight gains, and food consumption in the 50, 100, and

175 ppm group F 0 

## females were unaffected by test substance exposure. In addition, m ean

water consumption during the pre

- mating period for F 0 

## females in the 50, 100, and

175 ppm groups was similar to the control group. During gestation

, test

substance -related, higher mean maternal water consumption was noted in the 175 ppm

group F 0 

## females compared to the control group throughout gestation and was considered

adverse. I n the 100 ppm group, higher mean water consumption w as noted during
gestation day s 4 -7 compared to the control group ; h owever, mean water consumption in

this group was similar to the control group for the remaind er of gestation (gestation
day s 7- 20) and when the entire gestation exposure period (gest ation d ays 0

- 20) was
evaluated. T herefore, the higher mean water consumption noted for F 0 

## females at

100 ppm was considered test substance -related, but non adverse. During lactation, lower

mean water consumption was noted for the 50, 100, and 175 ppm group F 0 

## fe males
compared to the control group. H owever, no corresponding effects on body w eight or
food consumption parameters were noted for F 0 

## females in these groups during lactation;
therefore, the lower mean water consumption noted during lactation was attribu ted to biological variation and not considered test substance -related.

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F 0 

## male and female mating and fertility

, male copulation and female conception indices,

estrous cy clicit y, and the process of parturition were unaffected by t est substance

exposure a t all exposure levels. No exposure -related effects were observed on

F 0 

## spermatogenesis endpoints (mean testicular and epididy mal sperm numbers and sperm production rate, motility , progressive motility , and morphology ) in males at any e xposure
concentratio n. A test substance -related, adverse, higher mean pre

- coital interval and
longer mean gestation length were noted in the 175 ppm group F 0 

## females compared to

the control group. A lthough a longer mean gestation length was also noted at 100 ppm

and conside red test substance

- related, the value was within the range of values in the

WI L Research historical control data

, and therefore was not considered adverse. The

mean number of day s between pairing and coitus for F 0 

## females at 50, 100

, and
10,000 ppm and me an gestation length at 50 and 10,000 ppm were similar to the control

group values. The mean numbers of corpora lutea, implantation sites

, and

unaccounted

- for sites in the test substance

- exposed groups were similar to those in the
control group.

There were no test substance -related gross pathologic changes, microscopic changes, or

organ weight effects at any e xposure concentration. There were no test substance -related
effects on primordial/primary follicle counts in the 175 and 10,000 ppm groups.

The mean numbers of F 1 

## pups born, the pup sex ratio, and live litter size in the 50, 100,
175, and 10,000 ppm groups were unaffected by pa rental test substance exposure. In the

100 and 175 ppm groups, test substance

- related, lower postnatal survival was noted

duri ng PND 0 -1, 1-4, and from birth to PND 4 compared to the control group; the values

in the 175 ppm group were below the minimum mean values in the WI L Research

historical control data

, and therefore were considered adverse. The postnatal survival

values in the 100 ppm group were within the range of values in the WI L Research

historical control data, an d therefore were considered non adverse. Postnatal survival in

the 50 and 10,000 ppm groups was similar to the control group. No remarkable findings
regardin g the general phy sical condition of the F 1 

## pups were noted at any e xposure

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concentration. No adverse effects on m ean F 1 

## male and female pup body w eights and
body w eight gains were noted during PND 1 -4 at 50 , 100, 175, and 10,000 ppm. At the

necrops y for F 1 

## pups that were found dead, an increased incidence of interventricular
septal defect was noted in the 175 ppm group and was considered test substance -related

and adverse

.



# 1.4. **C ONCLUSION** 



## In t he 10,000 ppm group, adverse clinical signs (h ypoacti vity

, decrea sed respiration,
completely

s hut ey elids

, and lacrimation ) were noted for all F 0 

## males and females on the

first day o f test substance exposure. These findings were noted at approximately

15 minutes following test substance exposure and were resolved by ap proximately 1 hour
following exposure. In a ddition, lower mean F 0 

## male body w eights, body

w eight gains,

and food consumption were noted at this exposure level; no test substance -related effects

on body w eight or food consumption parameters were noted for F 0 

## females. The

aforementioned body

w eight and food consumption effects for F 0 

## males were considered

test substance -related and adverse within the context of a toxicology s tudy

. H owever, given that the 10,000 ppm exposure level was intended to mimic and assess a single

maximum ex posure in humans, the changes noted in mean body w eight gain and food
consumption that led to a reduction in mean body w eight onl y after 28 day s of exposure
would not be relevant to a single exposure scenario at the same exposure level. N o
effects on F 0 

## reproductive performance and F 1 

## offspring were noted at 10,000 ppm when

2

- Bromo -3,3,3- Trifluoropropene was administered as a daily 5

- minute whole- body
inhalation exposure.

Under the conditions of this screening study

, an exposure l evel of 100 ppm was
considered to be the no- observed -adverse- effect level (NOAEL) for female sy stemic
toxicity

, reproductive toxicity

, and neonatal toxicity based on the increase in mean water consumption for females during gestation, longer mean pre

- coita l interval, longer mean gestation length

, and the reduced postnatal survival noted in the 175 ppm group. The

NOAEL for F 0 

## male sy stemic t oxicity w as considered to be 175 ppm , the highest

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exposure concentration tested, based on the lack of adverse effects on sy stemic toxicity

for males at an y 6

- hour exposure regimen or at the 10,000 ppm 5

- minute exposure

.

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# 2. I **NTRODUCTION**


# 2.1. **G ENERAL**  

# S **TUDY** 

# I **NFORMATION**



## This report presents the data from “ An Inhalation Reproduction/Developmental Toxicity
Screening Study

o f 2

- Bromo -3,3,3

- Trifluoropropene in Rats

. ” D ue to software spacing
constraints, t

he study t itle is presented as “ Rat In hal Repro/ Dev/Tox Study o f

2

- Brom -3,3,3- Trifluoropropene ” on the report tables. For clarification of terminology

used to differentiate the gener ations in the report text, the offspring of the F 0 

## generation

were defined as the F 1 

## litters.

The study pr otocol and deviations from the protocol are presented in Appendix A

. A list
of abbreviations potentially used in this report is presented in Section 13

.

For the data collection process, each phase of the study w as separated into what were
termed WI L Research computer protocols. T he computer protocol reference numbers
and ty pes of data collected were identified as follows:

**Computer Protocol Type of Data Collected** 

WIL

- 65501M.......................................... F 0 

## male data WIL

- 65501F........................................... F 0 

## female data and F 1 

## litter data



# 2.2. **K EY**  

# S **TUDY** 

# D **ATES** 

## Date(s) **1** 

## Event(s) 25 September 2013

................................ . Study initiation date (date protocol signed by Study D irector) 26 September 2013

................................ . Experimental starting date (animal receipt) 14 October 2013

..................................... Experimental start date (initiation of F 0 

## test substance e xposure ) 14 October

- 11 November 2013

............ Test substance ex posure (F 0 

## males) 14 October

- 04 December 2013 ............ Test substance ex posure (F 0 

## females) 27 October

- 10 November 2013............ F 0 

## Mating period 12 November 2013

................................ . Last F 0 

## male necropsy 05 December 2013

.................................. Last F 0 

## fema le necropsy 21 February

2014.................................... Experimental termination/completion date (last skeletal examination )

1 

### D ate ran ges represent the first and last dates of evaluation.


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# 2.3. **P ARTICIPATING**  

# S **CIENTIST S**  

## Inhalation Exposure Analy sis Arthur J. Stephens, BA WI L Research



# 2.4. **C ONTRIBUTING**  

# S **CIENTISTS AND** 

# T **EST** 

# S **ITES** 

## Study Pathologist and Ovar ian Primordial Follicle Evaluation Catherine A. Picut, VMD, DACVP, DABT WI L Research



# 2.5. **P RINCIPAL**  

# I **NVESTIGATORS AND** 

# T **EST** 

# S **ITES** 

## Ovarian Histology Sirena Hudgins, HT (ASCP) WI L Research



# 2.6. **WIL R**  **ESEARCH** 

# K **EY** 

# S **TUDY** 

# P **ERSONNEL** 

## Susan C. Haley , BS Senior Laboratory Operations Manager Heather L. Johnson, BS, RQAP

- GL P Assistant Director, Quality and Regulatory Compliance Sally A. Keets, AS Senior Operations Manager, Central Scheduling Carol A. Kopp, BS, LAT Fetal Morphologist, Manager, Developmental Toxicology L ab oratory Erica L. Lashley , BS, LAT Senior Animal Operations Manager Gwendal yn M. Maginnis, DVM Attending Veterinarian George A. Parker, DVM, PhD, DACVP, DABT Vice President, Global Pathology

Theresa M. Rafeld, CPhT Night Manager, Nonclinical Operations Andrew J. Smith, BS Group Manager, Inhalation Toxicology Andrew M. Vick, PhD Senior Director, Anal yt ical Services Robert A. Wally , BS Operations Manager, Reporting & Technical Support Services

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# 3. S **TUDY** 

# D **ESIGN**



## Acclimation period

12 F 0 

## animals/se x/group exposed to the test substance or filtered air for 6 hours dail y (Groups 1 -4) at least 14 day s prior to mating. 12 F 0 

## animals/sex in Group 5 exposed to the test substance for 5 minutes and filtered air for the remainder of the 6

- hour exposure perio d daily at least 14 day s prior to mating

.
Clinical observation s , body weights

, and food and water consumption recorded at appropriate intervals

F 0 

## animals paired to produce F 1 

## litters

F 0 

## males exposed to the test substance or filt ered air daily

throughout mating and through the day prior to necrops y. F 0 

## females exposed to the test substance or filtered air daily through out mating and until gestation day 20 (females with evidence of mating) or through the day prior to necrops y (fem ale that failed to

deliver)

F 0 

## females allowed to deliver and rear their

pups to PND 4

Necropsies performed on F 1 

## pups found dead Necrops y performed on F 0 

## female with total litter loss

F 1 

## pup clinical observations and body weig hts recorded at appropriate intervals

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F 0 

## adults necropsied following completion of the mating period (males) or on post

- cohabitation day

25 or lactation day

4 (females); sperma togenic endpoints evaluated ( males ) ; selected organs weighed ; histopathological evaluation of selected tissues

F 1 

## pups euthanized and discarded on PND 4

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# 4. E **XPERIMENT**

**AL** 

# P **ROCEDURES** 

# - M **AT ERIALS**  **A ND**  

# M **ETHODS**


# 4.1. **T EST**  

# S **UBSTANCE A**  **ND** 

# C **ONTROL** 

# S **UBSTANCE**


# 4.1.1. **T EST**  

# S **UBSTANCE**



## The test substance

, 2 -Bromo -3,3,3

- Trifluoropropene , was received as follows:

Id entification Phy sical Description Date of Receipt Supplier

2

- Bromo -3,3,3- Trifluoropropene Lot no. WNCC

- BTP111128 Retest date: 22 October 2014 CAS no. 1514 -82-5 [WIL ID no. 130241] Pale y ellow liquid 19 September 2013 Sponsor

2

- Bromo -3,3,3- Trifluoropropene Lot no. WNCC

- BTP111128 Retest date: 22 October 2014 CAS no. 1514 -82-5 [ WIL ID no . 130263] Pale y ellow liquid 27 September 2013 Sponsor

Documentation regarding the purit y and stability of the test substance is on file with the
Sponsor and WIL Research

. A Certificate of Analy sis for the test substance was provided by

the Sponsor and is presented in Appendix B

. The purity of the test substance

was >99.4 %. The test substance contained small amounts of the following stabilizing

additives:

The test substance was stored at

room temperature and w as considered stable under this condition

. A reserve sample of

each shipment of the test substance was collect ed and stored in the WI L Research

Archives

.



# 4.1.2. **C ONTROL**  

# S **UBSTANCE**



## The control item used for exposure to the control group (Group 1) was filtered air.

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# 4.2. **E XPOSURE**  

# M **ETHODS** 

## Exposures for Groups 1 -4 were conducted in 1.0 -m 3 

## stainless steel and glass whole- body

inhalation exposure chambers and exposures for Group 5 were conducted in two 0.5 -m 3



## stainless steel and glass whole- body i nhalation exposure chamber s. F our chambers were
dedicated to the control, 50, 100, and 175 ppm groups while 2 cha mber s were dedicated

to Group 5 (1 chamber for test substance exposure and 1 chamber for filtered air
exposure). A ll chambers were op erated under dy namic conditions, at a slight negative

pr essure (ca. 0.5 in. of water) with at least 12 to 15 air changes p er hour

. Ox ygen content

of the exposure atmosphere was at least 19.0 % and was documented during the pre

- study

methods development phase. T emperature and relative humidity d uring exposures were
measured at least once every h our for each chamber and the da ily a verage was between

19°C and 25°C and 30% to 70%, respectively

. E xposure methods and chamber
environmental conditions are presented in Appendix C

.

All animals were housed in a normal animal colony r oom during non

- exposure hours.

For each day ’s exposure, the animals were transferred to exposure caging, transported to

the exposure chambe r room (Exposure Room 3 for Groups 1, 2, 3, and 4 and Exposure

Room 5 for Group 5), exposed for the requisite duration, and returned to their home

cages. Food and water were withheld during the exposure period. Animal cage batteries
were rotated through the various possible chamber locations on a daily basis.



# 4.3. **T EST**  

# A **TMOSPHERE** 

# G **ENERATION** 

# M **ETHODS**


# 4.3.1. **E XPOSURE**  

# C **HAMBERS** 

# 2, 3, **AND** 

# 4

A single vapor generator was used to produce a vapor and a distribution sy stem was used

to deliver a controlled amount of test substance to each chamber. T he single generator

consisted of a sealable 4

- neck reaction flask (1000 mL ) that was filled with an appropriate volume of test substance and heated to 29 ° C to 41 ° C using a mantle

- ty pe
heater (Glas

- Col, LLC, Terre Haute, IN) controlle d using a Powerstat variable

transformer (model no. 3PN116C, Superior Electric, Farmington, CT). Using a regulator
(Coilhose Pneumatics, In c., East Brunswick, NJ) and an Omega ® 

## digital mass flowmeter

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(model no

. FMA182 0), compressed nitrogen was metered to 1 port of the reaction flask

. Two ports were used to measure both the liquid and vapor temperatures separatel y within

the flask. T he temperatures were monitored using separate probes and Omega ® 

## PI D temperature controller s and process monitors (model no. CNi1654). The outlet port was
used to del iver test substance vapor to a stainless steel mixing

- tee through a 3

- way v alve
(by pass valve). With the 3

- way v alve in the “EXPOSURE” position, test substance

vapor was directed to the mixing tee where dilution air was added

. Using a Coilhose
regulator (model no. 8802K) and an Omega ® 

## digital mass flowmeter (model

no

. FMA 1820), compressed air was added to the mixing tee. The test substance
atmosphere was directed from the mixing tee to a stainless steel manifold where it was
distributed to each exposure chamber using compressed air

- powered, adjustable
transvector air pumps.

The vapor generator, distribution manifold, by pass valve and interconnecting Teflon ® 

## or
stainless steel tubing, and fittings were contained within a vented safet y cabinet. T he air
exiting the cabinet w as connected to the facility exhaust.

Using Coilhose regulator s (model no. 8802K), compressed air was supplied to each

transvector (VDF -100, Vaccon Company

, Inc., Medway

, MA) to control the po rtion of

test substance atmosphere pulled fro m the manifold. A metal orifice (O’Keefe Controls
Co., Trumbull, CT) w as placed in

- line after the manifold to restrict the flow directed to

each transvector. T est substance atmosphere was delivered to each cha mber inlet via 3 

## / 8 

## - inch poly eth yl ene line s. C hamber supply a ir was added to the chamber inlet where it

mixed with the test substance atmosphere to produce the desired exposure concentration
prior to entering the chamber.

A detailed description of the te st atmosphere generation method is presented in
Appendix C.

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# 4.3.2. **E XPOSURE**  

# C **HAMBER** 

# 5B **(10,000 PP**  **M** 

# )

A single vapor generator was used to produce a vapor atmosphere. A 5 00

- mL g as washing bottle, filled with an initial appropriate amount of test sub stance, was heated in

an oil bath. T he oil bath (Fisher Scientific Is otemp [model no. 102, Fisher Scient ific,
Waltham, MA]) was heated to between 63 ° C and 86 ° C monitored with a J- Ty pe thermocouple, and controlled using an Omega ® 

## PI D temperature controller and process
monitor (model no. CNi1654) (read

- out only ). Using an FMI Lab pump (model no. QG
20, Fluid Metering, Inc., Sy osset, NY)

, additional test substance was delivered at a

constant rate from the reservoir to the gas washing bottle. U sing a Co ilhose Pneumatics
regulator (model no. 8802K) and a rotameter

- ty pe flowmeter (model no. PMR1 -010649,

Cole

- Parm er, Vernon Hills, IL), compressed nitrogen was metered through a tube heater

to the inlet of the gas washing bottle. T he tube heater was heated to 89°C to 114°C,

monitored using a J- Ty pe thermocouple

, and controlled using an Omega ® 

## PI D

temperature control ler and process monitor (model no. CNi1654). Nitrogen was metered

into the inlet stem of the gas washing bottle where it passed through a fritted disk and

bubbled through the liquid test substance to produce vapors of the test substance

. Test

substance v apor from the gas washing bottle was delivered to the chamber inlet via 1⁄4-

inch poly eth yl ene line. C hamber supply a ir was added to the chamber inlet where it

mixed w ith the test substance vapor to produce the desired exposure concentration prior

to enterin g the chamber. The vapor generator and test atmosphere exposure chamber was

contained within a vented hood

.

A detailed description of the test atmosphere generation method is presented in
Appendix C.



# 4.4. **M ETHODS FOR**  

# C **HARACTERIZATION OF** 

# E **XPOSURE** 

# A **TMOSPHERES**


# 4.4.1. **N OMINAL**  

# C **ONCENTRATIONS**



## Because single vapor generation was used to produce a vapor and a di stribution sy stem

was used to deliver a controlled amount of test material to each chamber

, it was not

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possible to calculate nominal concentrations. T est substance usage was documented
daily

.



# 4.4.2. **A NALYZED**  

# E **XPOSURE** 

# C **ONCENTRATIONS** 

## Analy zed exposure concentrati ons were determined at approximately 6 0

- minute intervals
using a gas chromatograph (GC) under the control of the WI NH data acquisition software
application (Groups 1, 2, 3, and 4). Test atmosphere samples were collected
automatically

u sing a heated extern al multi

- position valve. For Chambers 5A and 5B,

anal yt ical samples were manually c ollected approximately h ourl y and twice during the

test substance exposure, respectivel y, using an external multi

- position valve (Model E16,

Valco Instruments Co., In c., Ho uston, TX) that permits sequential sampling from the

exposure room and each exposure chamber. Samples were collected from the
approximate animal

- breathing zone of the inhalation exposure chambers via heated

stainless steel sampling lines. G as sample inje ction onto the chromatograph y column

occurred via an internal gas

- sampling valve with sample loop. F or each sample, the
chromatograph was display ed and the area under the sample peak was calculated and
stored. The concentration in parts per million (ppm) was calculated using an ln

- quadratic
equation based on the GC calibration curve. A dditional details of the methods for

characterization of exposure atmospheres are presented in Appendix C and the results are
summarized in Section 6.1

.



# 4.5. **T EST**  

# S **YSTEM** 

# , A **NIMAL** 

# R **ECEIPT** 

# , **AND** 

# A **CCLIMATION** 

# P **ERIOD** 

## Sexually mature male and virgin female Sprague Dawley [ Crl:CD(SD) ] rats were used as
the test sy stem on this study

. The animal model, the Crl:CD(SD) rat, is recognized as appropriate for reproduction studies. WI L Research has reprodu ctive historical control

data for the Crl:CD(S D) rat

. This animal model has been proven to be susceptible to the

effects of reproductive toxicants. The number of animals selected for this study (see

Section 4.10. ) was based on the OECD Guidelines for the Testing of Chemicals,

Guideline 421, Reproduction/Developmental Toxicity S creening Test, 27 July 1 995,

which recommends evaluation of at least 8 pregnant females per group. G iven the

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possibility

o f nongravid animals, unexpected deaths, t otal litter losses, or

exposu re

- related moribundity a nd/or mortality

, this was an appropriate number of
animals to obtain a sample size of 8 animals per group at termination.

Crl:CD( SD) rats (66 males and 66 females) were received in good health from Charles

River Laboratories, In c., Portage, MI on 26 September 2013

. The animals were approximately 55 day s old upon receipt. E ach animal was examined by a q ualified
biologist on the day

o f receipt. The day

f ollowing receipt, all animals were weighed and

clinical observations were recor ded. Each rat was uniquely i dentified by

a M onel ® 

## metal

ear tag display ing the animal number. T he animals were housed for an acclimation
period of 18 day s prior to the first day o f treatment. D uring the acclimation period, the

animals were observed twic e daily f or mortality

a nd general changes in appearance and

behavior

, and the testes were palpated at least once for all males

.



# 4.6. **A NIMAL**  

# H **OUSING** 

# (N **ON** 

# -E **XP OSURE**  

# P **ERIODS** 

# )
Following receipt and until pairing, all F 0 

## animals were housed individually i n clean,

sta inless steel wire

- mesh cages suspended above cage

- board. T he cage

- board was changed at least 3 times per week. T he rats were paired for mating in the home cage of

the male. The animals were paired continuously d uring the mating period, except during

the exposure period. A nimals were individually h oused in stainless steel wire

- mesh
caging during the exposures, and then returned to their home cages in the animal colon y

room. Following positive evidence of mating, the males were housed in suspended

wire -m esh cages until the scheduled necrops y, and the females were transferred to plastic
maternity c ages with nesting material, ground corncob bedding (Bed

- O'Cobs ® 

## ; The
Andersons, Cob Products Division, Maumee, OH ). T he nesting material is periodicall y
anal yz ed by

t he manufacturer for contaminants. No contaminants were present in the
bedding at concentrations sufficient to interfere with the outcome of the study

. T he

results of these anal ys es are maintained at WIL Research . The dams and their litters were
ho used in these cages until euthanasia on lactation day 4

. Females with no evidence of
mating were housed in plastic maternity c ages until post

- cohabitation day 2 5. Animals

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were maintained in accordance with the Guide for the Care and Use of Laboratory

Ani mals ( National Research Council, 1996 ). T he animal facilities at WI L Research are
accredited by

A AALAC International. Enrichment devices were provided to all animals

as appropriate throughout the study f or environmental enrichment and to aid in
maintaining the animals’ oral health, and were sanitized weekly

.



# 4.7. **D IET**  

# , D **RINKING** 

# W **ATER** 

# , **A ND**  

# M **AINTENANCE**



## The basal diet used in this study

, PMI Nutrition In ternational, LLC Certified Rodent

LabDiet ® 

## 5002, wa s a certified feed with ap propriate analy ses performed by t he

manufacturer and provided to WIL Research

. Feed lots used during the study we re
documented in the study records. Feeders were changed and sanitized once per week.
Municipal water suppl yi ng the facility wa s regularly s ampled for contaminants according

to WI L Research’s SOP s. T he results of the diet and water anal ys es a re maintained at

WI L Research

. N o contaminants were present in animal feed or water at concentrations

sufficient to interfere with the objectives of thi s study

. R everse osmosis

- purified
(on

- site) drinking water, delivered by water bottles attached to the cages, and the basal

diet were provided ad libitum throughout the acclimation period and during the study

, with the following exception. Feed and water were withheld during the exposure periods.



# 4.8. **E NVIRONMENTAL**  

# C **ONDITIONS** 

# (N **ON** 

# -E **XPOSURE** 

# P **ERIODS** 

# )

All rats were housed throughout the acclimation period and during the study i n an environmentally

c ontrolled room. The room temperature and relative humidity c on trols

were set to maintain environmental conditions of 71 ° F ± 5 ° F (22 ° C ± 3 ° C) and
50% ± 20%, respectively

. Room temperature and relative humidity d ata were monitored
continuously

a nd were scheduled for automatic collection on an hourly basis. These data

are summarized in Appendix D

. Actual mean daily t emperature ranged from 70.3 ° F to

72.5 ° F ( 21. 3 ° C to 22.5 ° C) and mean daily r elative humidity ranged from 38.6 % to 49.7 % during the study

. Fluorescent lighting provided illumination for a 12

- hour light
(0600 hours to 1800 hours)/12

- hour dark photoperiod. The light status (on or off) was

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recorded onc e every

1 5 minutes. Air handling units were set to provide a minimum of

10 fresh air changes per hour.



# 4.9. **A SSIGNMENT**  **O F**  

# A **NIMALS T**  **O** 

# T **REATMENT** 

# G **ROUPS**



## At the conclusion of the acclimation period, all available males and females were weighed and examined in deta il for phy sical abnormalities. At the discretion of the Study

Director

, each animal judged to be in good health and meeting acceptable body w eight
requirements was selected for use in the compute rized randomization procedure based on
body w eight stratific ation in a block design. A t that time, the individual body w eights

and corresponding animal identification numbers were entered into WTDMS TM



## . A printout containing the animal numbers, corresponding body w eights, and individual
group assignments was genera ted

. The animals then were arranged into groups according

to the printout

. Animals not assigned to study w ere transferred to the WI L Research
stock colony

.

The experimental design consisted of 4 test substance

- exposed groups and 1 control
group composed of 12 rats/sex/group. A t the initiation of test substance exposure (study
day 0 ), the males and females were approximately 10 weeks old

. M ale b ody w eights
ranged from 338 g to 413 g and female body w eights ranged from 220 g to 273 g on study d ay 0

. T he animals were approximately 12 weeks old when paired on study
day 13 ; female body

weights ranged from 244 g to 325 g on gestation day 0.



# 4.10. **O RGANIZATION**  **O F**  

# T **EST** 

# G **ROUPS** 

# , D **OSAGE** 

# L **EVELS** 

# , **A ND**  

# T **REATMENT** 

# R **EGIMEN**



## The test substance or filtered air was administered via a dail y 6- hour whole- body

exposure for Groups 1

- 4. A nimals in Group 5 were administered the test substance via a daily 5

- minute whole

- body

exposure and were exposed to filtered air for the remainder of

the 6

- hour exposure period. The F 0 

## males were ex posed during study d ay 0 through
study d ay 2 7 or 28 (14 day s prior to pairing through the mating period up to 1 day p rior

to scheduled euthanasia) for a total of 28 -29 d ay s. The F 0 

## females were exposed during
study d ay s 0 through the day p rior to euthanas ia (14 day s prior to pairing through

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gestation day

20 ) for a total of 3 5

- 46 day s

. The female that failed to deliver was exposed
through the day

p rior to euthanasia (post

- cohabitat ion day 2 5) for a total of 52 day s. A ll

animals were exposed at approximate ly the same time each day

.
The following table presents the study group assignment:

Group Number Treatment Target Exposure Level (ppm) Number of

Males Number of

Females 1 Filtered Air 0 12 12

2 2

- Bromo -3,3,3-

Trifluoropropene 50 12 12

3 2

- Bromo -3,3 ,3-

Trifluoropropene 100 12 12

4 2

- Bromo -3,3,3-

Trifluoropropene 175 12 12

5 2

- Bromo -3,3,3-

Trifluoropropene 10,000 12 12

Exposure concentrations were determined from the results of a previous reproductiv e toxicity s creening study ( Brooker, 2013 ). I n that study

, rats were exposed to the test

substance daily

f or 6 hours for 15 day s prior to mating through lactation day 1 0 at

exposure levels of 200, 500, and 3000 ppm. E strous cy cles, pre

- coital intervals, and
gestation per iods were increased in a dose

- related manner and postnatal survival and litter

sizes were decreased. A no -observed -adverse- effect level (NOAEL) could not be

established based on the aforementioned findings. Based on these observations, the
highest exposu re level selected for the current study was 175 ppm for the 6

- hour

exposure and the lower exposure levels w ere selected to assess the dose

- response relationship. T he exposure level selected for the s hort 5

- minute ex posure period was
intended to mimic an a ctual expo sure from a complete discharge of a fire exti nguisher

within the space ty

pically e ncountered in an aircraft or a confined space representative
(according to the Sponsor) of the worst case for broader industrial, commercial, and other
applications found in fire protection

. I ndustry g uidelines for halon alternatives either

allow a 5- minute concentration at the lowest -observed -adverse- effect level ( LOAEL ) for

cardiac sensitization or 5- minute maximum concentration based on phy siologically based

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phar macokinetic ( PBPK ) modeling. T he cardiac sensitization LOAEL of

2

- Bromo -3,3,3-T rifluoropropene is 1% volume ( Horrell, 2002 ). T he exposure level

tested was equivalent to the test substance obtaining a 1% concentration in the
atmosphere of the enclosed aircraft or similar space. T he potential effects on reproduction and development have not been tested previously f or this exposure level and
duration, which is highly conservative based on the short exposure period that woul d be
expected in humans based on an actual exposure

.

The selected route of administration for this study was whole body i nhalation exposure
because the intended use of the test substance indicated that this would be a likel y route of human exposure.

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# 5. P **AR AMETERS**  

# E **VA LUA** 

**TED**


# 5.1. **C LINICAL**  

# O **BSERVATIONS A**  **ND** 

# S **URVIVAL**



## All F 0 

## rats were observed twice daily

, once in the morning and once in the afternoon, for
moribundity

a nd mortality . D etailed phy sical examinations were conducted weekly.

Each male and female was also observed for signs of toxicity approximately 1 hour
following the 6

- hour exposure period

. In addition, e ach male and female in Group 5 was

observed approximately

1 5 minutes and approximately 1 hour following the 5

- minute

exposure period. The absence or presence of findings w as recorded for all animals

. Females expected to deliver were also observed twice daily during the period of expected
parturition and at parturition for dy stocia (prolonged labor, delay ed labor) or other

difficulties.



# 5.2. **B ODY**  

# W **EIGHTS**



## Individual F 0 

## male body

w eights were recorded weekl y throughout the study

, beginning

on the first day

o f exposure, until the scheduled euthanasia. I ndividual F 0 

## female body
weights were recorded weekl y until evidence of copulation was observed. M ean weekl y body w eights and body weight changes are presented for each interval. I n addition,

cumulative mean body

w eight changes are presented for the pre

- mating period (males

and females) and for the entire generation (males only ). Once evidence of mating was

o bserved, female body

w eights were recorded on gestation day s 0, 4, 7, 11, 14, 17

, and

20 and on lactation day s 1 and 4. Mean gestation body w eights and corresponding mean body w eight changes are presented for these intervals and for the overall gestation

interval (day s 0 -20 ); mean lactation body weight changes a re presented for lactation
day s 1-4

. Weekl y body

w eights for females with no evidence of mating are presented o n
the individual report tables until necropsy. When body w eights could not be determi ned

for an animal during a given interval (as f emales enter gestation

, weighing error, etc .),

group mean values were calculated for that interval using the available data. The time
periods when body

w eight values were unavailable for a given animal were l eft blank or designated as “NA” on the individual report tables.

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# 5.3. **F OOD**  

# C **ONSUMPTION**



## Individual food consumption was recorded on the corresponding weekly b ody weight
day s until pairing. F ood intake was not recorded during the breeding period. O nce
evidence of mating was observed, F 0 

## female food consumption was recorded on gestation
day s 0, 4, 7, 11, 14, 17

, and 20 and on lactation day s 1 and 4. Following the breeding
period

, food consumption for females with no evidence of mating was measured on a
weekl y basis until the scheduled euthanasia. Weekly f ood consumption for females with

no e vidence of mating is presented o n the individual report tables until necrops y. Food
consumption was reported as g/animal/day a nd g/kg/day

f or the corresponding body
weight change intervals. C alculation of the comprehensive intervals excludes all
erroneous values such as total food spillage.

When food consumption could not be determined for an animal during a given interval
(due to a weighing error, food spillage, etc .), gro up mean values were calculated for that

interval using the available data. T he time periods when food consumption values were
unavailable for a given animal were left blank or designated as “NA” on the individual
report tables.



# 5.4. **W ATER**  

# C **ONSUMPTION**



## Individua l F 0 

## male and female water consumption was recorded on a daily b asis
beginning on the first day o f exposure until euthanasia and was reported on weekly basis.

Water intake was not recorded during the mating period. Once evidence of mating was observed, F 0 

## female water consumption was reported for the corresponding body w eight

intervals. Daily

w ater consumption for females with no e vidence of mating is presented

o n the individual report tables until necropsy. Water consumption was reported as g/animal/d ay

and g/kg/day

for the corresponding body weight change intervals.



# 5.5. **E STROUS**  

# C **YCLES** 

## Vaginal lavages were performed dail y and the slides were evaluated microscopically t o
determine the stage of the estrous cy cle of each female for 10 day s prior to test su bstance

administration and continuing until evidence of copulation was observed or until

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termination of the mating period for females with no evidence of mating. T he average

cy cle length was calculated and reported for complete estrous cy cles ( i.e.
, the t otal

number of returns to metestrus [M] or diestrus [D] from estrus [E] or proestrus [P] until

the detection of evidence of mating), beginning with the first day o f dose administration.

Estrous cy cle length was determined by c ounting the number of day s fr om the first M or

D in a cy cle to the first M or D in a subsequent cy cle. T he cy cle during which evidence

of mating was observed for a given animal was not included in the mean individual

estrous cy cle length calculation.



# 5.6. **B REEDING**  

# P **ROCEDURES**



## The animals were paired on a 1:1 basis within each treatment group following 14 day s of

exposure for the males and females. A b reeding record containing the male and female

identification numbers and the start date of cohabitation was maintained

. E ach female

was hou sed in the home cage of the male during cohabitation

. P ositive evidence of
mating was confirmed by t he presence of a vaginal copulatory p lug or the presence of

sperm following a vaginal lavage and verified by a s econd biologist

. E ach mating pair

was exam ined dail y. T he day w hen evidence of mating was identified was termed
gestation day

0

. I f evidence of copulation was not detected after 14 day s of pairing, an y females that had not shown evidence of mating were placed in plastic maternity cages.

For the purpose of calculating pre

- coital intervals, rats paired over a 12

- hour dark cy cle
were considered to have been paired for 1 day

.
Mating, fertility

, and copulation/conception indices were calculated as follows:

Male (Female) Mating Index (%) = No. of Males (Fem ales) with Evidence o f Mating (or Confirmed Pregnant ) x 100 Total No. of Males (Females) Used for Mating

Male Fertility Index (%) = No. of Males Siring a Litter x 100 Total No. of Males Used for Mating

Male Copulation Index (%) = No. of Males Siring a Litter x 100 No. of Males with Evidence of Mating (or Females with Confirmed Pregnancy)


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Fem ale Fertility Index (%) = No. of Females with Confirmed Pregnancy x 100 Total No. of Females Used for Mating

Fem ale Conception In dex (%) = No. of Females with Confirmed Pregnancy x 100

No. of Females with Evidence of Mating (or

Confirmed Pregnancy)



# 5.7. **P ARTURITION** 



## All females were allowed to deliver naturall y and rear their young to PND 4. D uring the
period of expected partu rition, the females were observed twice dail y for initiation and
completion of parturition and for signs of dy stocia. O n the day p arturition was initiated
(PND 0), pups were sexed and examined for gross malformations, and the numbers of

stillborn and live pups were recorded. I ndividual gestation length was calculated using
the date delivery

started.



# 5.8. **S PERMATOGENIC**  

# E **NDPOINT** 

# E **VALUATIONS** 

## Immediately

u pon euthanasia, the reproductive tract of each F 0 

## male was exposed via a
ventral mid

- line incision. T he righ t epididymis was excised and weighed. A n incision

was made in the distal region of the right cauda epididy mis. T he right cauda epididy mis

was then placed in Dulbecco's phosphate

- buffered saline (maintained at approximately

37 ° C) with 10 mg/mL B SA. A fter a minimum 10

- minute incubation period, a sample of

sperm was loaded o nto a slide with a 100

- μm chamber depth for determination of sperm motility

. B ecause sperm motility c an be affected by

t emperature shock, all pipettes,
slides, and diluents were warmed in an incubator, and motility d eterminations were performed under constant temperature (approximately 3 7 ° C). A nal ys is of a minimum of

200 motile and nonmotile spermatozoa per animal (if possible) in all groups was performed by

t he anal yzer. T he motility score (percent) for motile (showing motion
only ) and progressively

motile (showing net forward motion) sperm was reported:

Percent Motile (or Progressively

Motile) Sperm = Number of Motile (or Progressively Motile) Sperm x 100 Total Number of Sperm Coun ted



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The right testis and epididymis were then placed in modified Davidson’s solution for
subsequent microscopic examination. S perm morphology w as evaluated by

l ight
microscop y via a modification of the wet

- mount evaluation technique ( Linder et al.

, 1992 )

. A bnormal forms of sperm (double heads, double tails, microcephalic or megacephalic, etc .) from a differential count of 200 spermatozoa per animal, if possible,

were recorded.

The left testis and cauda epididy mis from e ach male were weighed

, stored frozen,
homogenized, and analy zed for determination of homogenization

- resistant spermatid

count and calculation of sperm production rate ( Blazak et al. , 1985 ). An aliquot of each
sample was a dded to a solution containing a DNA

- specific fluorescent dy e (the dy e stains

DNA that is present in the head of the sperm). For analy sis, each sample was mixed, and
an aliquot was placed on a slide with a 20

- μm chamber depth. Illumination from a xenon

la mp within the analy zer allowed for the visualization and quantitation of the sperm. A

minimum of 200 cells, if possible, or up to 20 fields were counted for each sample. T he
sperm production rate was calculated as follows:

Sperm Production Rate = No. of Sperm Per Gram of Tissue 6.1 Days

6.1 Days = The rate of turnover of the germinal epithelium



# 5.9. **A NATOMIC**  

# P **ATHOLOGY**


# 5.9.1. **M ACROSCOPIC**  

# E **XAMINATION**



## A complete necrops y was conducted on all F 0 

## parental animals at the scheduled

termination. All F 0 

## adults were e uthanized by carbon dioxide inhalation

. M ales were
euthanized following completion of the mating period. Females that delivered were
euthanized on lactation day 4 ; the number of former implantation sites and corpora lutea

were recorded. The female that failed to deliver was euthanized on post

- cohabitation
day 25

. Uteri with no macroscopic evidence of implantation were opened and
subsequently

p laced in 10 % ammonium sulfide solution for detection of earl y

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implantation loss ( Salewski, 1964 ). The female with total litter loss was euthanized

within 24 hours of litter loss. Necrops y included examination of the external surface, all

orifices

, the external surface of the brain, and the cranial, thoracic, abdominal

, and pelvic
cavities, including viscera. Clinical findings that were verified at necrops y were designated CEO ( correlates with externally o bserved ). At the time of necrops y, the
following tissues and organs were placed in 10% neutral

- buffe red formalin (except as

not ed):

Brain Pituitary gland Coagulating glands Prostate gland Kidney s Seminal vesicles (2) Li ver (sections of 2 lobes) Spleen Lungs Testes with epididy mides (2) b 

## and vas deferens Mammary

glands (females only

) Uterus c 

## with cervix and vagina Ovaries a 

## and oviducts (2) All gross lesions d

a 

## = Ovaries were fixed in 10% neutral

- buffere d formalin for approximately 48 hours following which all ovaries were transferred to 70% ethanol.
b



## = Testis (right) and epididymis (right and remainder of left) were pl aced in modified Davidson’s solution ; care was taken to ensure separation between the left and right organs.

c 

## = Any uterus stained in 10% ammonium sulfide solution for detection of implantation sites was discarded and not preserved in 10% neutral

- buffere d formalin.
d



## = Representative sections of corresponding organs from a sufficient number of control animals were retained for comparison, if possible.



# 5.9.2. **O RGAN**  

# W **EIGHTS** 

## The following organs were weighed from all F 0 

## animals at the scheduled necropsies:

Brain Lungs Epididy mides (total and caudal) a 

## Ovaries (without oviducts) Kidney s Pituitary gland Li ver Spleen Testes a

a 

## = These paired organs were weighed separ ately ; care was taken to ensure separation between the left and right organs.

Except a s noted, paired organs were weigh ed together. A bsolute weights and organ to final body

weight and organ to brain weight ratios were reported.

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# 5.9.3. **H ISTOLOGY AND**  

# M **ICROSCOPIC** 

# E **XAMINATIONS** 

## Microscopic evaluations were performed on the following tissues for all F 0 

## parental

animals from the contr ol, 175, and 10,000 ppm groups.

Cervix Coagulating gland Epididy mides a 

## Lungs Mammary

glands (female only ) Ovaries b 

## Pituitary gland Prostate gland Seminal vesicles Spleen Testis a 

## Uterus Vagina Vas deferens All gross (intern al) lesions (all groups)

a 

## = Transverse sections of 2-4 microns of the testes and longitudinal sections of the epididy mides were stained in PAS and hematox yl in in addition to routine hematox yl in and eosin staining.
b



## = All ovaries were paraffin embedded. Five sectio ns were taken approximately 100 μm apart from the inner third of each ovary from all of the F 0 

## females in the control, 175, and 10,000 ppm groups at the scheduled necropsy a nd for any

f emales suspected of reduced fertility

. I n addition, a sin gle section was taken for a qualitative bilateral evaluation of each ovary

. A q uantitative histopathologic evaluation of multiple sections was conducted. T his examination included enumeration of the total number of primordial follicles according to the m ethods of Bolon et al . (1997)

, Bucci et al . (1997) , and Picut et al . (2008)

.

After fixation, protocol

- specified tissues were shipped to WIL Research Hill sborough for
processing. T he tissues were trimmed according to the WI L Research Hillsborough

SOPs and the protocol. T rimmed tissues were processed into para ffin blocks, sectioned
according to WIL Research’s SOPs , mounted on glass microscope slides

, and s tained

with hematox yl in and eosin

.
The pathology

report is presented in Appendix E.



# 5.10. **F 1**  

# L **ITTER** 

# P **ARAMETERS**


# 5.10.1. L **ITTER** 

# V **IABILITY A**  **ND** 

# D **EATHS**



## Each litter was exa mined daily f or survival, and all deaths were recorded. A ll pups were individually

i dentified by

a pplication of tattoo markings on the digits following
completion of parturition. A d aily r ecord of litter size was maintained. I ntact offspring

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that were found dead were necropsied using a fresh dissection technique

, which included

examination of the heart and major vessels ( Stuckhardt and Poppe, 1984 ). Pups with
suspected skeletal anomalies were eviscerated and stained ( Dawson, 1926 ) for
subsequent skeletal evaluation. Findings were recorded as either developmental

variations (alterations in anatomic structure that are considered to have no significant
biological effect on animal health or body c onformity

a nd/or occur at high incidence,
representing slight deviations from normal) or malformations (those structural anomalies

that alter general body

c onformity

, disrupt, or interfere with normal body f unction, or

may b e incompatible with life) as appropriate. Specimens with malformations were preserved in 10% neutral

- buffered formalin for possible future histopathologic
examination. The carcass of each pup was then discarded.



# 5.10.2. C **LINICAL** 

# O **BSERVATIONS**



## Litters were examined daily f or survival an d any

a dverse changes in appearance or
behavior. E ach pup received a detailed phy sical examination on PND 1 and 4. An y
abnormalities in nesting and nursing behavior were recorded.



# 5.10.3. B **ODY** 

# W **EIGHTS** 

## Pups were individuall y weighed on PND 1 and 4. M ean pup weig hts were presented by

sex for each litter and by dose group. When body weights could not be determined for a

pup during a given interval (due to an unscheduled death, weighing error, etc .), group mean values were calculated for that interval using the ava ilable data. The time periods a
given pup was not weighed were left blank or designated as “NA” on the individual
report tables.



# 5.10.4. S **EX** 

# D **ETERMINATION** 

## Pups were individually

sexed on PND 0 and 4.

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# 5.10.5. C **ALCULATION O**  **F** 

# L **ITTER** 

# P **ARAMETERS** 

## Litter parameters were defin ed as follows:

Mean Live Litter Size = Total No. of Viable Pups on PND 0 No. of Litters with Viable Pups PND 0

Postnatal Survival Between Birth and

PND 0 or PND 4 (% Per Litter) = Sum of (Viable Pups Per Litter on PND 0 or PND 4/No. of Pups Born P er Litter) No. of Litters Per Group x 100

Postnatal Survival for All Other Intervals (% Per Litter) = Sum of (Viable Pups Per Litter at End of Interval N/Viable Pups Per Litter at Start of Interval N) No. of Litters Per Group x 100

Where N = PN D 0

- 1 and 1

- 4



## Total litter loss was determined when the last pup in the litter was found dead prior to the

scheduled euthanasia.



# 5.10.6. S **CHEDULED** 

# E **UTHANASIA**



## On PND 4, surviving F 1 

## rats were euthanized via an intraperitoneal inj ection of sodium
pentobarbital an d discarded without examination.



# 5.11. **D ATA**  

# A **CQUISITION AND** 

# A **NALYSIS**


# 5.11.1. A **CQUISITION AND** 

# R **EPORTING**
Program/System Description Archive Management System (AMS) In

- house developed application for storage, maintenance, and retrieval of information for archived material s ( e.g. , lab books, study data, wet tissues, slides, etc .)

Hamilton

- Thorne Integrated Visual Optical System (IVOS) Sperm Analyzer Optical computer combination unit (Hamilton Thorne Research) designed to analyze the motion, concentration, and fluorescent behavior of sperm from experimental animals. Inhalation Exposure Data Collection System (WINH) Monitors and records inhalation chamber temperature, relative humidity, ventilation rate, and negative pressure

InSi ght ® 

## Publisher Electronic publishing system (output is Adobe Acrobat, PDF)

Master Schedule Maintains the master schedule for the company.



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Program/System Description Metasys DDC Electronic Environmental Control System Controls and monitors animal room environmental conditions.

Microsoft ® 

## Office 2007 Used in conjunction wi th the publishing software to generate study reports.

WIL Metasys In

- house developed system used to record and report animal room environmental conditions. WIL Toxicology Data Management SystemTM (WTDMSTM) In

- house developed system used for collection an d reporting of in

- life and postmortem data.
Note: Version numbers of WTDMSTM programs used for the study are presented on the report data tables (reporting programs); version numbers and release dates are otherwise maintained in the study records and/or fa cility records.



# 5.11.2. S **TATISTICAL** 

# A **NALYS ES** 



## All statistical tests were performed using WTDMSTM unless otherwise noted. A naly ses

were conducted using two

- tailed tests (except as noted otherwise) for minimum
significance levels of 1% and 5%, comparing each test substance

- exposed group to the

control group by sex. Each mean was presented with the standard deviation (S.D.),

standard error (S.E.), and the number of animals (N) used to calculate the mean. Due to

the use of significant figures and the different roun ding conventions inherent in the ty pes of software used, the means, standard deviations , and standard errors on the summary and

individual tables may

d iffer slightl y. T herefore, the use of reported individual values to

calculate subsequent parameters or m eans will, in some instances, yi eld minor variations

from those listed in the report data tables. Data obtained from nongravid females were
excluded from statistical analy ses following the mating period. W here applicable, the
litter was used as the exper imental unit.

Parental mating, fertility, conception

, and copulation indices were analy zed using the

Chi

- square test with Yates’ correction factor ( Hollander and Wolfe, 1999 ). P arental body
weights (weekl y, gestation, and lactation), body weight changes

, and food and water consumption, offspring body w eights and body

w eight changes, gestation length, estrous

cy cle length, numbers of former implantation sites and corpora lutea

, number of pups born, live litter size on PND 0, unaccounted

- for sites, absolute and relative organ
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weights, pre

- coital intervals, sperm production rates, epididy mal and testicular sperm numbers, and ovarian primordial follicle counts were subjected to a parametric one- way

ANOVA ( Snedecor and Cochran, 1980 ) to determine intergroup differences. I f the

ANOVA revealed significant (p<0.05) intergroup variance, Dunnett's test ( Dunnett,

1964 ) was used to co mpare the test substance

- exposed groups to the control group. Mean

litter proportions (percent per litter) of males at birth and postnatal survival

, percentages of

motile and progressively m otile sperm, and percentages of sperm with normal
morphology were subjected to the Kruskal -Wallis nonparametric ANOVA ( Kruskal and
Wallis, 1952 ) to determine intergroup differences. I f the nonparametric ANOVA

revealed significant (p<0.05) intergroup variance, Dunn’s test ( Dunn

, 1964 ) was used to

compare the test substance

- exposed groups to the control group. H istopathological
findings in the test substance

- exposed groups were compared to the control group using a

two -tailed Fisher’s Exact test ( Steel a nd Torrie, 1980 ).

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# 6. R **ESUL**

**TS**


# 6.1. **A NALYZED**  

# E **XPOSURE** 

# C **ONCENTRATIONS** 

## Exposure Atmosphere Generation Report: Appendix C

Daily m ean test atmosphere concentrations for each exposure are presented in
Appendix C. T he overall mean anal yz ed concentrations are presented in the f ollowing

table

.

**Text Table 1.**  **Overall Mean Exposure Concentrations**

Exposure Chamber: 1 2 3 4 5A 5B*
Target Concentration

(ppm ): 0 50 100 175 0 10,000

Mean Concentration

(ppm ): 0 50 101 174 0 10,076

Standard Deviation: 0.0 3.2 4.8 10.7 0.0 607.9

N: 38 39 40 52 38 38
* = Mean obtained from T=4 minutes and T=9 minutes; the animals were present in the exposure chambers for 4 minutes prior to the first concentration sampling.



# 6.2. **F 0**  

# G **ENERATION**


# 6.2.1. **C LINICAL**  

# O **BSERVATIONS A**  **ND** 

# S **URVIVAL** 

## Summary Data: Table S1

, Table S2

, Table S3

, Table S4

, Table S5

, Table S6

, Table S7

, Table S8

Individual Data: Table A1

, Table A2

, Table A3

, Table A4

, Table A5

, Table A6

,

Table A7

, Table A8

All males and females in the control, 50, 100, 175, and 10,000 ppm groups survived to

the scheduled necropsies. One female (no. 91654) in the 175 ppm group had total litter
loss on lactation day

2 and was subsequentl y euthanized.

In the 10,000 ppm group, test substance

- related clinical findings of hy poactivity

, decreased respiration, completely s hut ey elids

, and lacrimation were noted for all males

and females at 15 minutes following test substance exposure on the f irst day o f exposure

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(study day 0). These findings did not persist to 1 hour following exposure and were only

noted on study

d ay 0

. Salivation and red and/or clear material around the mouth and/or

nose were noted for males and females in the 10,000 ppm g roup throughout the
respective exposure periods at approximately 15 minutes and/or 1 hour following

exposure and were considered test substance

- related.

No other test substance -related clinical findings were noted at an y exposure level at the

weekl y deta iled phy sical examinations or 1 hour following the 6 -hour exposure period

. Red material around the nose was noted for males and females in all groups, including

the control group, at 1 hour following the 6 -hour exposure period generally t hroughout

the res pective exposure periods

. Other clinical findings noted in the test

substance

- exposed groups, including hair loss on various body s urfaces, occurred
infrequentl y, at similar frequencies in the control group, and/or in a manner that was not

exposure

- relate d.



# 6.2.2. **B ODY**  

# W **EIGHTS**


# 6.2.2.1. **M ALES**  

## Summary Data: Table S9

, Table S10

Individual Data: Table A9

, Table A10

In the 10,000 ppm group, lower mean body w eight gains were noted throughout the

exposure period compared to the control group and resulted in lower mean body w eight
gains when the pre

- mating period (study day s 0

- 13) and the entire exposure period (study
day s 0

- 28) were evaluated; differences were generally significant (p<0.05 or p<0.01). In
addition, mean body

w eight s were 6.7% lower than the control group on study d ay 2 8 ;
the difference was significant (p<0.05)

. The aforementioned changes were considered

te st substance -related and adverse within the context of a toxicology s tudy

. H owever, given that the 10,000 ppm exposure level was intended to mimic and assess a single

maximum ex posure in humans, the changes noted in mean body w eight gain that led to a
red uction in mean body

w eight onl y after 28 days of exposure would not be relevant to a single exposure scenario at the same exposure level.

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Mean body

w eight gains for males in the 100 and 175 ppm groups were similar to the

control group during study d ay s 0 -2 1 and when the pre

- mating period (study d ay s 0

- 13)

was evaluated. L ower mean body w eight gains were noted in these groups compared to

the control group during study d ay s 21 -28 and resulted in slightly lower mean body
weight gains in the 100 and 175 ppm gr oups when the ent ire exposure period (study
day s 0- 28) was evaluated ; the differences were generall y significant (p<0.05)

, but were

not dose

- responsive

. T he changes in mean body w eigh t gain noted in the 100 and

175 ppm groups during the latter half of the exposure period were not of sufficient
magnitude to a ffect mean body w eights in these groups, and therefore were considered
likely test substance

- related but non

- adverse.

Mean body

w eights and body

w eight gains in the 50 ppm group males were unaffected
by t est substance exposure throughout the study

. N one of the differences from the
control group were statistically significant.



# 6.2.2.2. **F EMALES** 


# 6.2.2.2.1. **P RE**  

# -M **ATING** 

## Summary Data: Table S11

, Table S12

Individual Data: Table A11

, Table A12

Mean body

w eights and body

w eight gains in the 50, 100, 175, and 10,000 ppm group
females were unaffected by t est substan ce exposure during the pre

- mating period (study
day s 0 -13) . None of the differences from the control group were statistically significant.



# 6.2.2.2.2. **G ESTATION**  

## Summary Data: Table S13

, Table S14

Individual Data: Table A13

, Table A14

Mean body

w eights and body

w eight gains in the 50, 100, 175, and 10,000 ppm groups

were unaffected by

t est substance exposure during gestation. N one of the differences

from the control group were statisticall y significant

, with the following exceptions

. Significantl y (p<0.05 or p<0.01) lower mean body w ei ght gains were noted in the

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175 ppm group during gestation day s 0-4 and 11 -14 and in the 10,000 ppm group durin g

g estation day s 11

- 14. These differences were transient and not of sufficient magnitude to

a ffect the overall gestation exposure period (gesta tion day s 0

- 20) or mean body w eights
in these groups, and therefore were not considered test substance -related.



# 6.2.2.2.3. **L ACTATION**  

## Summary Data: Table S15

, Table S16

Individual Data: Table A15

, Table A16

Mean body

w eights and body

w eight gains in the 50, 100, 175, and 10,000 ppm gro ups

were unaffected by

t est substance exposure during lactation. N one of the differences
from the control group were statisticall y significant.



# 6.2.3. **F OOD**  

# C **ONSUMPTION**


# 6.2.3.1. **M ALES**  

## Summary Data: Table S17

, Table S18

Individual Data: Table A17

, Table A18

Mean food consumption, evaluated as g/animal/day a nd g/kg/day

, in the 1 0,000 ppm

group was lower throughout the pre

- mating period (study d ay s 0- 13) compared to the

control group; differences were generall y significant (p<0.05 or p<0.01). The lower

mean food consumption noted in this group corresponded with the lower mean bod y weight gains noted during the pre

- mating period in this group. The aforementioned
changes were considered test substance -related and adverse within the context of a toxicology

study . However, given that the 10,000 ppm exposure level was used to mimic

and assess a single maximum exposure in humans, the changes noted in mean food
consumption following 13 day s of exposure would not be relevant to a single exposure scenario at the same exposure level.

Mean food consumption in the 50, 100, and 175 ppm group males was similar to that in

the control group during the pre

- mating period (study d ay s 0 -13). Differences from the

control group were slight and not statistically s ignifican t, with the following exception:

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S ignificantl y (p<0.05) lower mean g/kg/day f ood consumption was noted in the 100 ppm

group compared to the control group during study d ay s 7-13. There was no effect on g/animal/day

f ood consumption or mean body weights in this group and this slight

difference did not occur in an exposure

- related manner

. T herefore, the lower mean food
consumption noted in the 100 ppm group was not considered test substance

- related.



# 6.2.3.2. **F EMALES** 


# 6.2.3.2.1. **P RE**  

# -M **ATING** 

## Summary Data: Table S19

, Table S20

Individual Data: Table A19

, Table A20

Mean food consumption, evaluated as g/animal/day and g/kg/day

, in the 50, 100, 175,

and 10,000 ppm group females was unaffected by t est substance exposure during the

pre

- mating period (study day s 0 -13). Differences from the control group were slight and

not statistically

s ig nificant, with the following exception s : S ignificantly ( p<0.05 o r p<0.01) lower mean food consumption was noted in the 175 and 10,000 ppm groups compared to the control group during study d ay s 0 -7. H owever, these differences were
transient and not of sufficient magnitude to affect mean body w eights in these groups and

were not considered test substance -related.



# 6.2.3.2.2. **G ESTATION**  

## Summary Data: Table S21

, Table S22

Individual Data: Table A21

, Table A22

Mean maternal food consumption, evaluated as g/animal/day a nd g/kg/day

, in the 50,
100, 175, and 10,000 ppm groups was unaffected by t est substance exposure during
gestation. Differences from the control group were slight and not statistically sig nifican t,

with the following exception: Significantly ( p<0.05 or p<0.01) lower mean food
consumption w as noted in the 175 ppm group compared to the control group during
gestation day s 0 -4. T his difference was not of sufficient magnitude to affect the overall

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gestation exposure period (gestation day s 0- 20) or mean body w eights in this group; therefore, it was not considered test substance

- related.



# 6.2.3.2.3. **L ACTATION**  

## Summary Data: Table S23

, Table S24

Individual Data: Table A23

, Table A24

Mean maternal food consumption

, evaluated as g/animal/day a nd g/kg/day

, in the 50,
100, 175, an d 10,000 ppm groups was unaffected by t est substance exposure during
lactation. None of the differences from the control group were statistically significant.



# 6.2.4. **W ATER**  

# C **ONSUMPTION**


# 6.2.4.1. **M ALES**  

## Summary Data: Table S25

, Table S26

Individual Data: Table A25

, Table A26

Mean water consumption, evaluated as g/ animal/day a nd g/kg/day

, in the 50, 100, 175,

and 10,000 ppm group males was similar to that in the control group throughout the

pre

- mating period (study d ay s 0 -13)

. N o statistically s ignificant differences were
observed.



# 6.2.4.2. **F EMALES** 


# 6.2.4.2.1. **P RE**  

# -M **ATING** 

## Summary Data: Table S27

, Table S28

Individual Data: Table A27

, Table A28

Mean water consumption, evaluated as g/animal/day a nd g/kg/day

, in the 50, 100, 175,

and 10,000 ppm group females was unaffected by t est substance exposure during th e

pre

- mating period (study d ay s 0

- 13)

. N one of the differences from the control group
were statisticall y significant.

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# 6.2.4.2.2. **G ESTATION**  

## Summary Data: Table S29

, Table S30

Individual Data: Table A29

, Table A30

Test substance -related, higher mean maternal water consumption

, evaluated as g/an imal/day

a nd g/kg/day

, was noted in the 175 ppm group compared to the control

group generall y throughout the gestation exposure period and resulted in higher mean

water consumption in this group when the entire gestation exposure period (gestation
day s 0 -2 0) was evaluated; differences were generall y significant (p<0.01) and were
considered adverse. In the 100 ppm group, mean water consumption was similar to the

control group during gestation day s 0 -4. D uring gestation day s 4

- 7, significantl y (p<0.01) high er mean water consumption was noted in the 100 ppm group compared to

the control group and was considered test substance -related. H owever, mean water consumption was similar to the control group or only s lightl y higher (not statistically
significant) for the remainder of the gestation exposure period (gestation day s 7

- 20) and

when the entire gestation exposure period (gestation day s 0

- 20) was evaluated.
Therefore, the higher mean water consumption at 100 ppm during gestation day s 4

- 7 was

considered likel y test substance -related, but non adverse.

M ean maternal water consumption in the 50 and 10,000 ppm groups was unaffected by

test substance exposure during gestation. N one of the differences from the control group
were statisticall y significant.



# 6.2.4.2.3. **L ACTATION** 



## S ummary Data: Table S31

, Table S32

Individual Data: Table A31

, Table A32

Mean maternal water consumption, evaluated as g/animal/day a nd g/kg/day, in the 50,
100, 175, and 10,000 ppm groups was unaffected by t est substance exposure during

lactation

. L ower m ean maternal water consumption was noted in the 50, 100, and
175 ppm groups during lactation day s 1 -4 compared to the control group; differences

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were generall y s ignificant (p<0.05 or p<0.01)

. However, mean body w eights, body
weight gains, and food consumption were unaffected during lactation at these exposure levels. Therefore, the lower mean water consumption noted at 50, 100, and 175 ppm was
attributed to biological variation and not considered test substance

- related.



# 6.2.5. **R EPRODUCTIVE**  

# P **ERFORMANCE** 

## Summary Data: Table S33

, Table S34

Individual Data: Table A33

, Table A34

Historical Control Data: Appendix F

F 0 

## ma le and female reproductive parameters are presented in the followi ng table.

**Text Table 2**  **. Results of Reproductive Performance** 
Dosage Level (ppm) WIL HC a



### Parameter 0 50 100 175 10,000 Mean (Range) Male Mating Index 100.0 100.0 100.0 91.7 100.0 95.5 (86.7

- 100.0)
Fem ale Mating Index 100.0 100.0 100.0 91.7 100.0 96.3 (8 6.7

- 100.0) Male Fertility Index 100.0 100.0 100.0 91.7 100.0 87.5 (70.0

- 100.0)
Fem ale Fertility Index 100.0 100.0 100.0 91.7 100.0 88.0 (70.0

- 100.0) Male Copulation Index 100.0 100.0 100.0 100.0 100.0 92.4 (70.0

- 100.0)
Fem ale Conception Index 100.0 100 .0 100.0 100.0 100.0 92.3 (70.0

- 100.0) Estrous Cycle Length (days) 5.2 4.6 4.9 5.0 5.1 4.5 (4.0

- 5.8)
Pre

- Coital Interval (days) 2.9 2.9 2.4 4.5 2.0 3.0 (1.8

- 4.7)

a 

### = WIL historical control data



## No exposure -related effects on male and female reproducti ve indices were observed at

any exposure concentration

. No statistically s ig nificant differences were noted between

the control and test substance

- exposed groups. With the exception of 1 male in the

175 ppm group, all males sired a litter.

A higher (no t statistically s ig nificant) mean pre

- coital interval was noted in the 175 ppm

group compared to the control group; 4 of the 1 1 pairs of mated animals in this group had

pre

- coital intervals greater than 5 day s in length. T herefore, the higher pre

- coital i nterval
in the 175 ppm group was considered test substance

- related and adverse.

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The mean numbers of day s between pairing and coitus in the 50, 100, and 10,000 ppm

groups were similar to the control group value. T he mean lengths of estrous cy cles in all

te st substance

- exposed groups were similar to the control group value. N one of these
differences were statistically significant.



# 6.2.6. **G ESTATION**  

# L **ENGTH A**  **ND** 

# P **ARTURITION** 

## Summary Data: Table S35

, Table S36

Individual Data: Table A35

, Table A36

Historical Control Data: Appendix F

Test substance -related, significantl y (p<0.01) longer mean gestation lengths were noted

in the 100 (22.3 day s) and 175 ppm (22 .6 day s) groups compared to the control group (21.7 day s). Although there were no signs of dy stocia at an y exposure level in the study

, the gestation length in the 175 ppm group exceeded the maximum mean value in the WIL

Research historical control data (22.3 day s) and 7 of the 11 females that delivered had a gestation length of 23 day s versus 0 of 12 females in the control group; therefore, this
change was considered adverse. T he mean gestation length at 100 ppm, although
statistically significantly incr eased, was within the range of values in the WI L Research
historical control data (21.5

- 22.3 day s), a nd therefore was considered non adverse.

Mean gestation lengths in the 50 and 10,000 ppm groups were similar to those in the
control group. No statisticall y significant differences were noted.



# 6.2.7. **S PERMATOGENIC**  

# E **NDPOINT** 

# E **VALUATIONS** 

## Summary Data: Table S37

, Table S38

Individual Data: Table A37

, Table A38

Historical Control Data: Appendix F

No exposure

- related effects were observed on F 0 

## spermatogenesis endpoints (mean
testicular and epididymal sperm numbers and sperm production rate, motility , progressive
motility

, and morphology ) in males at an y exposure concentration. D ifferences from the
control group were slight and were not statistically significant.

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# 6.2.8. **A NATOMIC**  

# P **ATHOLOGY**


# 6.2.8.1. **M ACROSCOPIC**  

# E **XAMINATIONS** 

## Summary Data: Table S39

, Table S40

, Table S41

, Table S42

, Table S43

Individual Data: Table A39

, Table A40

, Table A41

, Table A42

, Table A43
Pathology

Report: Appendix E

All F 0 

## males and females survived to the scheduled necropsies. No test substance -related

internal findings were observed at an y exposure level in the female that failed to deliver,

the female with total litter loss

, or males and females at the scheduled necrops y. Macroscopic findings observed in the tes t substance

- exposed groups occurred
infrequentl y in single animals and/or in a manner that was not dose -related.

The mean numbers of corpora lutea, unaccounted

- for sites

, and implantation sites in the
50, 100, 175, and 10,000 ppm groups were similar to the control group values.



# 6.2.8.2. **O RGAN**  

# W **EIGHTS** 

## Summary Data: Table S44

, Table S45

Individual Data: Table A44

, Table A45

, Table A46

, Table A47

, Table A48

, Table A49
Pathology

Report: Ap pendix E

There was a test substance -related lower (7.1%, p<0.05) final body weight in the
10,000 ppm group males. T here were no test substance -related alterations in organ weights.

Some organ weight differences were statistically s ig nificant whe n compared to the

control group, however, these changes were considered secondary to the test

substance -related effect on final body w eight. Th ere was a significant ly ( p<0.01) higher

left epididymis weight relative to final body w eight in the 10,000 ppm group males.

Since the change did not correlate to histologic findings and the mean absolute weight

was not affected, the change was considered to be due to the lower mean final body
weight. There was a significant ly (p<0.01) higher right testis weight relative to body

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weight in the 10,000 ppm group males. This change was also a result of a low mean final
body weight in this dose group, and was not test substance -related.

Some statistically

s ig nificant differences were observed when the control and test

substance

- treated groups were compared, but the changes were not considered test

substance -related. There was a significantl y (p<0.01) higher me an lung weight relative to
body w eight and a significantly ( p<0.01) higher mean lung w eight relative to brain
weight in the 175 ppm group males compared to the control group

. Because the mean
absolute lung weight was not affected, the relative weights wer e within the WIL Research

historical control data range s, and there were no histopathologic correlates, the changes in
relative weights were not considered toxicologically significant. There were significant ly
(p<0.05 or p<0.01) lower pituitary w eights (a

bsolute and relative) in 100, 175, and /or
10,000 ppm group males and females; however, because the changes did not follow a
dose

- response profile, were within the WIL Research historical control range, and did not

correlate to histologic findings at 175 or 10,000 ppm, the statistically s ignificant changes

were consid ered spurious.



# 6.2.8.3. **M ICROSCOPIC**  

# E **XAMINATIONS** 

## Summary Data: Table S46

, Table S47

, Table S48

, Table S49

, Table S50

Individual Data: Table A39

, Table A40

, Table A41

, Table A42

, Table A50 Pathology

Report: Appendix E

There were no test substance -related microscopic findings. A ll histologic changes were
consi dered to be incidental findings or related to some aspect of experimental
manipulation other than administration of the test substance

. T here was no test

substance -related alteration in the prevalence, severity

, or histologi c character of those

incidental tissue alterations.

There was n o apparent test substance -related effect on the counts of primordial and
primary follicles from ovaries in the control, 175, and 10,000 ppm group females.

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# 6.3. **F 1**  

# L **ITTER** 

# D **ATA**


# 6.3.1. **PND 0 L**  **ITTER** 

# D **ATA A**  **ND** 

# P **OSTNATAL** 

# S **URVIVAL** 

## Summary Data: Table S51

, Table S52

Individual Data: Table A51

, Table A52

, Table A53

Historical Control Data: Appendix F

The mean number of pups born, live litter size

, and the percentage of males at birth in the
50, 100, 175, and 10,000 ppm groups were similar to the control group values.

Postnatal survival on PND 0 (relative to number born) in all test substance

- exposed

groups was similar to the control group. Test s ubstance -related, lower (not statistically
significant) p ostnatal survival was noted in the 100 and 175 ppm groups compared to the
concurrent control group during PND 0

- 1, 1

- 4, and from birth to PND 4 ; the values in the

175 ppm group were below the minimum mean values in the WIL Research historical

control data

, and 1 female in this group (no. 91654) had a total litter loss on PND 2.
Therefore, the postnatal survival at this exposure level was considered adverse. The
postnatal survival values in the 100 p pm group were within the range of values in the

WI L Research historical control data, an d therefore were considered within normal limits

and not adverse

. Postnatal survival values for all groups are presented in the following

table.

**Text Table 3.**  **Summar y of Postnatal Survival (% per litter)** 
Dosage Level (ppm) WIL HC a



### Parameter 0 50 100 175 10,000 Mean (Range) PND 0 (relative to number born) 96.5 98.0 95.2 95.4 97.0 98.0 (93.3

- 100.0)
PND 0 to PND 1 99.2 98.1 96.1 91.7 99.4 98.7 (94.6

- 100.0)
PND 1 to PND 4 97.1 95.9 91.7 76.5 99.3 98.4 (87.0

- 99.8)
Birth to PND 4 92.8 92.1 84.1 67.9 95.7 95.3 (83.8

- 98.7)

a 

### = WIL historical control data



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# 6.3.2. **G ENERAL**  

# P **HYSICAL** 

# C **ONDITION** 

## Summary Data: Table S53

Individual Data: Table A54

The general phy sical condition (defined as the occurrence and severity o f clinical
findings) of all F 1 

## pups in this study was unaffected by parental administration of the test

substance

. P ups (litters) that were found dead numbered 11(8), 11(6), 16(9), 33(10), and
7(4) in the control, 50, 100, 175, and 10,000 ppm groups, respectively

. One (1), 2(2),
7(5), and 18(5) pups (litters) in the control, 50, 100, and 175 ppm groups , respectively

,

were missing during PND 1 -4 and presumed to have been cannibalized.



# 6.3.3. **O FFSPRING**  

# B **ODY** 

# W **EIGHTS** 

## Summary Data: Table S54

, Table S55

Individual Data: Table A55

, Table A56

Historical Control Data: Appendix F

Mean male and female pup body w eights and body

w eight changes during PND 1 -4 in

the 50, 100, 175, and 10,000 ppm groups were unaffected by p aren tal administration of

the test substance

. H igher mean male and female pup birth weights (PND 1) were noted

for males and females in the 50, 100, and 10,000 ppm groups compared to the control
group; differences were significant (p<0.01) for male pup body w eights only

i n these

groups. However, mean body w eights on PND 4 and mean body w eight gains during

PND 1 -4 in these groups were similar to the control group. T herefore, the higher mean
male and female pup birth weights on PND 1 were not considered advers e (see

Section 7. )

. I n the 175 ppm group, mean pup birth weights (PND 1) were similar to the
control group.

**Page 57 of 1107**

## WI L-65501 2

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# 6.3.4. **N ECROPSIES**  **O F**  

# P **UPS** 

# F **OUND** 

# D **EAD** 

## Summary Data: Table S56

Individual Data: Table A57

The numbers of pups (litters) that were found dead numbered 11(8), 11(6), 16(9), 33(10),

and 7(4) in the control, 50, 100, 175, and 10,000 ppm groups, respectively

. One (no. 91631 -08 ) and 5 (nos. 91654 -05, 91654 -07, 91654 -08, 91654 -12, and

91681 -08) pups in the 100 and 175 ppm group s, respecti vel y, were noted with an
interventricular septal defect (a 1 or 2 mm in diameter opening in the anterior portion of

the septum) ; this malformation was considered test substance

- related at 175 ppm. A t

100 ppm, only

a s ingle pup was affected and postnatal s urvival was within the WIL

Research historical control data ranges; therefore, the incidence was not considered test

substance -related.

No other test substance -related malformations or developmental variations were noted at

any e xposure level. I n the 175 ppm group, 1 pup (no. 91682

- 01) was noted with

vertebral agenesis

, anal atresia, and fused kidneys; this pup was also noted with a major

blood vessel variation (retroesophageal right subclavian artery ; right subclavian artery

coursed retroesophageal and j oined aortic arch adjacent to the ductus arteriosus [no
brachiocephalic trunk]). Dark red con tents in the thoracic cavity w ere observed for pup

no. 91622 -01 in the 175 ppm group. B ecause the aforementioned malformations and
developmental variation s were noted in single pup s, they w ere not considered test

substance -related. A conjoined twin was noted in the control group.

**Page 58 of 1107**

## WI L-65501 2

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# 7. D **ISCUSSION** 

## This study

was designed to provide information on the potential adverse effects of the test

substance on male and female reproduction within the scope of a screening study

. T his
encompassed gonadal function, mating behavior, conception, parturition, and lactation of

the F 0 

## generation and the development of offspring from conception through day 4 o f
postnatal life.

No tes t substance

- related effects on survival were noted in the 10,000 ppm group

F 0 

## males and females. T est substance -related clinical findings of hy poactivity

, decreased
respiration, completel y shut ey elids

, and lacrimation were noted for males and females at
10,000 ppm on the first day o f exposure (study day 0 ); however, these findings were
resolved by approximately 1 hour following exposure. S alivation and red and/or clear

material around the mouth and/or nose were noted for F 0 

## males and females in this grou p throughout the respective exposure periods at approximately 15 minutes and/or 1 hour
following the 5

- minute exposure. T here were no remarkable macroscopic findings or

organ weight changes noted for F 0 

## males and females in the 10,000 ppm group at the

sch eduled necrops y. I n the 10,000 ppm group F 0 

## males, lower mean body w eight gains

were noted throughout the exposure period and corresponding lower mean food
consumption was noted during the pre

- mating period (study d ay s 0

- 13). T hese

differences resulted in a lower mean body w eight in this group compared to the control

group on study

d ay 2 8. T he aforementioned body w eight and food consumption effects

for F 0 

## males were considered test substance -related and adverse within the context of a toxicology

s tudy

. However, given that the 10,000 ppm exposure level was intended to

mimic and assess a single maximum exposure in humans, the changes noted in mean body w eight gain and food consumption that led to a reduction in mean body w eight onl y
after 28 day s of exposu re would not be relevant to a single exposure scenario at the same

exposure level. T here were no test substance -related effects on mean water consumption

for F 0 

## males at 10,000 ppm or on mean body w eight, body

w eight gain, and food and

water consumption f

or F 0 

## females at 10,000 ppm. Furthermore, no effects on F 0 

## reproductive performance or F 1 

## offspring were noted in the 10,000 ppm group.

**Page 59 of 1107**

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All F 0 

## males and females in the control, 50, 100, and 175 ppm groups survived to the

scheduled necropsies. N o test su bstance

- related clinical or macroscopic findings were noted in the 50, 100, and 175 ppm groups. No adverse test substance

- related effects were

noted on mean body

w eights, body

w eight changes, and food consumption for F 0 

## males

and females at these exposure concentrations during the respective exposure periods.

Test substance

- related, higher mean maternal water consumption was noted in the

175 ppm group females compared to the control group throughout gestation and was
considered adverse. M ean water consum ption was generally s imilar to the control group
for F 0 

## males throughout the exposure period and for F 0 

## females during the pre

- mating
period and lactation.

In the 175 ppm group females, a higher mean pre

- coital interval and longer mean gestation length wer e noted compared to the control group; these differences were
considered test substance -related and adverse. In addition, test substance -related, lower
postnatal survival was noted in the 175 ppm group compared to the control group during

PND 0 -1, 1- 4, an d from birth to PND 4 and was considered adverse.

Higher mean male and female pup birth weights (PND 1) were noted for males and

females in the 50, 100, and 10,000 ppm groups compared to the control group

. T his was likely due to the slight increases in m ean gestation length noted in these groups compared

to the control group. F etal weight gain occurs rapidl y during late gestation and
immediately

p rior to delivery

. A lthough not adverse and within WIL Research historical

control data, there was a 0.4 to 0 .6 day i ncrease in the gestation length noted in these

groups compared to the control group, which may h ave attributed to the increased pup weights noted. H owever, mean body w eights on PND 4 and mean body weight gains
during PND 1 -4 in these groups were s imilar to the control group. T herefore, the higher

mean male and female pup birth weights on PND 1 may h ave been secondary

t o the
slightly i ncre ased gestation length and were not considered adverse. I n the 175 ppm

group, mean pup birth weights (PND 1) we re similar to the control group. I t would be
expected that the longer gestation length would produce higher mean birth weights in

**Page 60 of 1107**

## WI L-65501 2

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pups, as mentioned previously

. A n increased gestation length that was outside of the

WI L Research historical control values and considered adverse was noted at 175 ppm. The lack of a statistical increase in the mean pup body weights at 175 ppm was likely due

to a potential developmental delay o r a reduction in mean pup body w eights that was
masked b y the increased gestation pe riod.

At the necrops y for F 1 

## pups that were found dead, an increased incidence of

interventricular septal defect was noted in the 175 ppm group

. Experimentally i nduced

interventricular defects have been shown to close during postnatal development and ca n
be considered a developmental delay i n the cardiac sy stem that may o r may n ot be

considered adverse depending on the size of the opening and the impact on viability a nd
growth of the pups ( Fleeman

, et al. , 2004 ). T he in terventricular defects in this study

were noted in pups that were found dead. T herefore, while these observations may h ave
been related to the apparent developmental delay n oted in the 175 ppm group, they w ere
considered test substance -related and adverse when coupled with the reduction in
postnatal survival noted in this group.

F 0 

## male and female reproductive indices

, spermatogenic endpoints, and the mean
numbers of corpora lutea, impl antation sites, and unaccounted

- for sites were similar to

the control group value s at 50, 100, and 175 ppm. The number of day s between pairing

and coitus and mean gestation lengths were unaffected by t est substanc e exposure at

50 and 100 ppm. No noteworthy findings were observed during the process of parturition

and no re markable organ weight changes were noted for parental animals at exposure
levels of 50, 100, and 175 ppm. In F 1 

## pups, mean numbers of pups born, live litter size,

and percentage of males per litter at birth in the 50, 100, and 175 ppm groups were
similar to the control group values. I n the 50 and 100 ppm groups, postnatal survival was

unaffected b y test substance exposure. No noteworthy findings were noted on the general
phy sical condition of F 1 

## pups at 50, 100, and 175 ppm and at necrops y for F 1 

## pups fo und
dead at 50 and 100 ppm.

**Page 61 of 1107**

## WI L-65501 2

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# 8. C **ONCLUSIONS**



## In t he 10,000 ppm group, adverse clinical signs (h ypoactivity, decreased respiration,
completely

s hut ey elids, and lacrimation) were noted for all F 0 

## males and females on the

first day o f test substance exposu re. T hese findings were noted at approximately

15 minutes following test substance exposure and were resolved by a pproximately

1 hour
following exposure. I n addition, lower mean F 0 

## male body w eights, body

w eight gains,

and food consumption were noted at this exposure level; no test substance -related effects

on body w eight or food consumption parameters were noted for F 0 

## females. The

aforementioned body

w eight and food consumption effects for F 0 

## males were considered

test substance -related and adverse wit hin the context of a toxicology s tudy

. H owever, given that the 10,000 ppm exposure level was intended to mimic and assess a single

maximum ex posure in humans, the changes noted in mean body w eight gain and food
consumption that led to a reduction in mean body w eight onl y after 28 day s of exposure
would not be relevant to a single exposure scenario at the same exposure level. N o
effects on F 0 

## reproductive performance and F 1 

## offspring were noted at 10,000 ppm when

2

- Bromo -3,3,3- Trifluoropropene was administ ered as a daily 5

- minute whole- body
inhalation exposure.

Under the conditions of this screening study

, an exposure level of 100 ppm was
considered to be the no- observed -adverse- effect level (NOAEL) for female sy stemic
toxicity

, reproductive toxicity

, and n eonatal toxicity b ased on the increase in mean water consumption for females during gestation, longer mean pre

- coital interval, longer mean gestation length, and the reduced postnatal survival noted in the 175 ppm group. The

NOAEL for F 0 

## male sy stemic tox icity w as considered to be 175 ppm, the highest

exposure concentration tested, based on the lack of adverse effects on sy stemic toxicity

for males at an y 6

- hour exposure regimen or at the 10,000 ppm 5

- minute exposure.

**Page 62 of 1107**

# WIL-6550 1 American Pacific Corporation



# 9. REPORT REVIEW AND 

# APPROVAL

Report Authored and Approved 

# By: 

# ---I&* 

# A CCLLd,.. cL> 

## Tadye 

# L. Edwards, 

# BS Senior Toxicologist, Developmental and Reproductive Toxicology Study Director

Report Prepared 

# By:
A



## Study Aglyst

Report Reviewed 

# By:

n

, 

# -y

Jaime 

# L. Mesnard, 

## MS

Group Supervisor, Reporting & Technical Support Services

Eddie 

## D. Slo’Eer, PhD Associate Director, Developmental and Reproductive Toxicology Date



# =ua/y

Date

Page 

## 63 of 1107

## WI L-65501 2

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American Pacific Corporation



# 10. **Q UALITY**  

# A **SSURANCE** 

# S **TAT EMENT** 

Date(s) of Inspection(s) Phase Inspected Date(s) Findings Reported to Study Director and Management

25 -Sep- 2013 P rotocol 25 -Sep- 2013

14

- Oct

- 2013, 15

- Oct

- 2013 Test Article Exposure 15

- Oct

- 2013

22

- Oct

- 2013 Protocol Amendment 1 22

- Oct

- 2013

20

- Nov

- 2013 Parturition 20

- Nov

- 2013

25

- Nov

- 2013 Necropsy 25

- Nov

- 2013

18

- Dec

- 2013 Trimming of Tissues 18 -D ec

- 2013

03

- Jan

- 2014 Protocol Amendment 2 03

- Jan

- 2014

29

- Jan

- 2014, 11 -Feb- 2014 Study Records (I

- 1) 11 -Feb- 2014

31

- Jan

- 2014 Study Records (Ex

- 2) 31

- Jan

- 2014

31

- Jan

- 2014, 07 -Feb- 2014 Study Records (Ex

- 1) 07 -Feb- 2014

06 -Feb- 2014, 07-Feb- 2014 Study Records (Ex

- 3) 07 -Feb- 2014

07 -Feb- 2014 Exposure Atmosphere Generation Report 07 -Feb- 2014

07 -Feb- 2014 Study Records (Ex

- 4) 07 -Feb- 2014

07 -Feb- 2014 Study Records (Ex

- 5) 07 -Feb- 2014

07 -Feb- 2014 Study Records (Ex

- 6) 07

- Fe b- 2014

07 -Feb- 2014 Study Records (Ex

- 1) Supplemental 07 -Feb- 2014

10 -Feb- 2014 Study Records (N

- 1) 10 -Feb- 2014

10 -Feb- 2014 Study Records (N

- 2) 10 -Feb- 2014

10 -Feb- 2014 Study Records (H

- 1) 10 -Feb- 2014

10 -Feb- 2014 Study Records (Patholo gy Data) 10 -Feb- 2014



## Page 64 of 1107

## WIL-65501 American Pacific Corporation 2-Bromo-3,3,3 -Trifluoropropene

Date(s) 

### of Inspection(s) Phase Inspected

1 1

-Feb-20 14 Pathology Report Date(s) Findings Reported to Study Director and Manapement



### 1 1 -Feb-20 14

1 1 

### -Feb-2014 Study Records (1-2) 1 1 

### -Feb-20 14

1 1 

### -Feb-2014 Study Records 

### (1-3) 1 1 

### -Feb-20 14

1 1 

### -Feb-2014 Study Records (1-4) 1 1 

### -Feb-20 14

1 

### 1 -Feb-20 14 Study Records (1-5) 1 1 -Feb-20 14



### 1 1 

### -Feb-2014 Study Records (1-6) 1 1 -Feb-20 14

13-Feb-2014 Report (without Inhalation or Pathology Appendices) 13-Feb-20 14

13-Mar-20 14 Final Inhalation Report 13-Mar-201 4

17-Mar-20 14 Final Pathology Report 17-Mar-201 4

1 

### 8-Mar-20 14 Study Records (N-2) Supplemental 18-Mar-20 14

19-Mar-20 14 Amendment to the Final Inhalation Report 1 9-Mar-20 1 4

19-Mar-20 14 Final Report 19-Mar-201 4



## This study was inspected in accordance with the applicable GLP Regulations, WIL

Research’s SOPs, and the protocol and protocol amendments, with the following
exception: The data located in Appendix B (Certificate 

## of Analysis) were the
responsibility of the Sponsor. A yearly internal facility inspection is conducted by the

WIL Research Quality Assurance Department.

This report accurately reflects the data generated during the study. The methods and
procedures used in the study were those specified in the protocol, its amendments, and

WIL Research’s SOPs.

Alan 

## D. Deppe, 

## BA 

# ’ Quality Assurance Representative I



## Page 

## 65 of 

## 1107

# WIL Research Hillsborough 

# 3 10 Millstone Drive Hillsborough, NC 27278 WIL-65501 American Pacific Corporation

Date(s) Findings Date(s) Reported Reported To Date (s) Findings To Study Date(s) of Principal Reported To Test Director and Inspection Phase Inspected Investigator Site Management Testing Facility

27-Dec-20 13 Automated IHC 

## Staining 27-Dec-2013 27-Dec-2013 02-Jan-20 14 and Coverslipping



## I O& 12-Mar- Histology Documentation 12-Mar-20 14 12-Mar-20 14 1 8-Mar-20 14 

## 2014



# The portions of this study conducted at WIL Research Hillsborough were inspected in

accordance with the applicable Good Laboratory Practice Regulations, SOPs and
protocol and protocol amendments. A yearly internal facility inspection is conducted by

the Quality Assurance Department.

The methods and procedures used in the portions of this study conducted at WIL
Research Hillsborough were those specified in the protocol, its amendments, and SOPs.



# /B 

# JYdv 

# 2014

Date

**Page 66 of 1107**

## WI L-65501 2

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# 11. **R EFERENCES** 



## Blazak, W.F.; Ernst, T.L .; Stewart, B.E. Potential indicators of reproductive toxicity : testicular s perm production and epididy mal sperm number, transit time and motility in Fischer 344 rats. Fundamental and Applied Toxicology **1985** , 5, 1097

- 1103.

Bolon, B.; Bucci, T.J .; Warbritton, A.R.; Chen, J.J.; Mattison, D.R.; Heindel, J.J. Differential follicle counts as a screen for chemically i nduced ovarian toxicity i n mice: results from continuous breeding bioassays. Fundamental and Applied Toxicology **1997**

, 39(1) , 1

- 10.

Brooker, A.J. 2

- bromo

- 3,3,3

- trifluoropropene: Reproductive/Developmental Toxicity S cree ning Study

i n the CD Rat by

I nhalation Administration (Study No. WAG0015) . Hunting don Life Sciences

. **2013**

. Bucci, T.J.; Bolon, B.; Warbritton, A.R.; Chen, J.J. ; Heindel, J. J. In fluence of sampling on the reproducibility of ovarian follicle counts in mou se toxicity s tudies. Reproductive Toxicology **1997**

, 11(5) , 689

- 696.

Dawson, A.B. A n ote on the staining of the skeleton of cleared specimens with Alizarin Red S. Stain Technology **1926**

, 1 , 123

- 124.

Dunn, O.J

. Multiple comparisons using rank sums. Techn ometrics **1964**

, 6(3)

, 241

- 252.

Dunnett, C.W. N ew tables for multiple comparisons with a control. Biometrics **1964**

, 20 , 482

- 491.

Fleeman, T.L .; Cappon, G.D.; and Hurtt, M.E. P ostnatal Closure of Membranous Ventricular Septal Defects in Sprague

- Dawley R at Pups After Maternal Exposure With Trimethadione Birth Defects Research (Part B) **2004**

, 71 :185

- 190.

Hollander, M.; Wolfe, D.A. Nonparametric Statistical Methods , 2nd ed.; Hollander, M., Wolfe, D.A., Eds.; John Wiley and Sons, I

nc.: New York, NY, **199 9**  ; p 468.

Horrell, P.J. Agent 873: An I nhalation Study

to Investigate the Cardiac Sensitisation Potential in the Beagle (Study N o. AAS 001/014630)

. H unti ngdon Li fe Sciences, Lt d

. **2002**

. Kruskal, W.H.; Wallis, W.A. U se of ranks in one

- criterion varia nce analy sis. Journal of the American Statistical Association **1952**

, 47 , 583

- 621.

**Page 67 of 1107**

## WI L-65501 2

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Li nder, R.E.; Strader, L.F.; Slott, V.L .; Suarez, J.D. Endpoints of spermatotoxicity in the rat after short duration ex posures to fourteen reproductive toxicants. Reproduc tive Toxicology **1992**

, 6 , 491

- 505.

National Research Council. Guide for the Care and Use of Laboratory Animals

, Institute of Laboratory Animal Resources, Commission on Li fe Sciences; National Academy Press: Washington, DC, **1996**

. Picut, C.A.; Swanson, C.L .; Scully

, K.L .; Roseman, V.C.; Parker, R.F.; Remick, A.K. Ovarian Follicle Counts Using Proliferating Cell Nuclear Antigen (PCNA) and Semi

- Automated I

mage Analy sis in Rats. Toxicologic Pathology **2008**

, May 8

. Salewski, E. Färbemethode zum makroskopisc hen Nachweis von Implantationsstellen am Uterus der Ratte. [ Staining method for a macroscopic test for implantation sites in the uterus of the rat]. Naunyn

- Schmiedebergs Archiv für Experimentelle Pathologie und Pharmakologie **1964**

, 247 , 367.

Snedecor, G.W.; Cochran, W.G. O ne

- Way C lassifications; Analy sis of Variance. In Statistical Methods

, 7th ed.; The Io wa State University P ress: A

mes, IA

, **1980** ; pp 215

- 237.

Steel, R.G.D.; Torrie, J.H. Principles and Procedures of Statistics, A Biometrical Appro ach

, 2nd ed.; McGraw

- Hill Book Company : N ew York, NY, **1980** ; pp 504

- 506.

Stuckhardt, J.L .; Poppe, S.M. F resh visceral examination of rat and rabbit fetuses used in teratogenicity

t esting. Teratogenesis, Carcinogenesis and Mutagenesis **1984**

, 4 , 181

- 188.

**Page 68 of 1107**

## WI L-65501 2

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# 12. **D ATA**  

# R **ETENTION**



## The Sponsor has title to all documentation records, raw data, specimens, or other work
product generated during the performance of the study . A ll remaining work product
generated by

W IL Research

, including raw paper data and spe cimens, are retained in the

WI L Research Archives as specified in the study protocol. All work product generated at

WI L Research Hillsborough will be returned to WIL Research Ashland.

Reserve samples of the test substance , pertinent electronic storage media, and th e original

f inal report are retained in the WIL Research Archives in compliance with regulatory
requirements

.

**Page 69 of 1107**

## WI L-65501 2

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# 13. **A BBREVIA** 

**TIONS** 

## The following abbreviations may apply to this report:

μ

- micro AAALAC

- Association for Assessment and Accreditation of Laboratory

Animal Care ANOVA

- anal ys is of variance BSA

- Bovine serum albumin CEO

- correlates with externally observed

cm

- centimeter dL

- deciliter DNA

- deox yribonucleic acid EPA

- Environmental Protection Agency
exp.

- expiration
g

- gram GC

- gas ch romatograph GL P

- Good Laboratory Practices hr

- hour(s) kg

- kilogram L

- liter M

- molar
mg

- milligram mL

- milliliter

mm

- millimeter

ms

- milliseconds mM

- millimolar NA

- not applicable

no (s)

. - number (s) OECD

- Organisation for Economic Cooperation and Development PAS

- Periodic Acid Schiff PND

- Postnatal day
ppm

- parts per million SOP

- standard operating procedure TSCA

- Toxic Substances Control Act WTDMSTM

- WI L Toxicology Data Management S ys tem
wt (s)

. - weight (s)

**Page 70 of 1107**

## WI L

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene

American Pacific Corporation



# SUMMARY **TABLES**

**Page 71 of 1107**TABLE S1 (F0 MALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS

----- M A L E -----

----------------------------------------------------------------------------------------------------------------------------------- TABLE RANGE: 10-14-13 TO 11-12-13 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NORMAL -NO SIGNIFICANT CLINICAL OBSERVATIONS 51/11 45/11 42/10 40/10 54/11

DISPOSITION -SCHEDULED EUTHANASIA 12/12 12/12 12/12 12/12 12/12

BODY/INTEGUMENT -HAIR LOSS RIGHT FORELIMB 9/ 2 11/ 4 16/ 4 18/ 5 6/ 2 -HAIR LOSS LEFT FORELIMB 9/ 2 11/ 4 16/ 4 20/ 6 5/ 1 -HAIR LOSS LEFT INGUINAL AREA 0/ 0 3/ 1 0/ 0 0/ 0 0/ 0

EYES/EARS/NOSE -DRIED RED MATERIAL AROUND LEFT EYE 0/ 0 0/ 0 3/ 1 0/ 0 0/ 0 -DRIED RED MATERIAL AROUND RIGHT EYE 0/ 0 0/ 0 2/ 1 0/ 0 0/ 0

ORAL/DENTAL -UPPER INCISORS MALALIGNED 0/ 0 0/ 0 3/ 1 0/ 0 0/ 0 -TEETH LONG; TRIMMED 0/ 0 0/ 0 2/ 1 0/ 0 0/ 0

----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM PCSUv4.07 11/25/2013**Page 72 of 1107**TABLE S2 (F0 MALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS

----- M A L E -----

----------------------------------------------------------------------------------------------------------------------------------- TABLE RANGE: 10-14-13 TO 11-11-13 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NORMAL -NO SIGNIFICANT CLINICAL OBSERVATIONS 0/ 0 0/ 0 0/ 0 0/ 0 53/11

BEHAVIOR/CNS -HYPOACTIVITY 0/ 0 0/ 0 0/ 0 0/ 0 12/12

BODY/INTEGUMENT -WET CLEAR MATERIAL RIGHT FORELIMB 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1 -WET CLEAR MATERIAL LEFT FORELIMB 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1

CARDIO-PULMONARY -DECREASED RESPIRATION 0/ 0 0/ 0 0/ 0 0/ 0 12/12

EYES/EARS/NOSE -DRIED RED MATERIAL AROUND NOSE 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1 -WET RED MATERIAL AROUND NOSE 0/ 0 0/ 0 0/ 0 0/ 0 12/ 6 -EYELIDS COMPLETELY SHUT 0/ 0 0/ 0 0/ 0 0/ 0 12/12 -LACRIMATION 0/ 0 0/ 0 0/ 0 0/ 0 12/12 -DRIED RED MATERIAL AROUND LEFT EYE 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1

ORAL/DENTAL -WET CLEAR MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 0/ 0 162/12

----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM**Page 73 of 1107**TABLE S2 (F0 MALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS

----- M A L E -----

----------------------------------------------------------------------------------------------------------------------------------- TABLE RANGE: 10-14-13 TO 11-11-13 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

ORAL/DENTAL -SALIVATION 0/ 0 0/ 0 0/ 0 0/ 0 254/12 -WET RED MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 0/ 0 11/ 3

----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM PCSUv4.07 11/25/2013 R:01/20/2014**Page 74 of 1107**TABLE S3 (F0 MALES - 1 HOUR POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS

----- M A L E -----

----------------------------------------------------------------------------------------------------------------------------------- TABLE RANGE: 10-14-13 TO 11-11-13 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NORMAL -NO SIGNIFICANT CLINICAL OBSERVATIONS 0/ 0 0/ 0 0/ 0 0/ 0 261/12

EYES/EARS/NOSE -DRIED RED MATERIAL AROUND NOSE 0/ 0 0/ 0 0/ 0 0/ 0 14/ 5 -WET RED MATERIAL AROUND NOSE 0/ 0 0/ 0 0/ 0 0/ 0 10/ 6 -DRIED RED MATERIAL AROUND LEFT EYE 0/ 0 0/ 0 0/ 0 0/ 0 2/ 1

ORAL/DENTAL -WET CLEAR MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 0/ 0 40/11 -SALIVATION 0/ 0 0/ 0 0/ 0 0/ 0 2/ 2 -WET RED MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 0/ 0 24/ 6 -DRIED RED MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 0/ 0 8/ 4

----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM PCSUv4.07 11/25/2013 R:01/20/2014**Page 75 of 1107**TABLE S4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS

----- M A L E -----

----------------------------------------------------------------------------------------------------------------------------------- TABLE RANGE: 10-14-13 TO 11-11-13 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NORMAL -NO SIGNIFICANT CLINICAL OBSERVATIONS 327/12 314/12 324/12 318/12 333/12

EYES/EARS/NOSE -DRIED RED MATERIAL AROUND NOSE 15/ 4 28/11 15/ 7 21/10 7/ 4 -WET RED MATERIAL AROUND NOSE 0/ 0 0/ 0 1/ 1 0/ 0 0/ 0 -DRIED RED MATERIAL AROUND LEFT EYE 0/ 0 0/ 0 3/ 1 0/ 0 2/ 1 -DRIED RED MATERIAL AROUND RIGHT EYE 0/ 0 0/ 0 3/ 1 0/ 0 1/ 1

ORAL/DENTAL -WET CLEAR MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 2/ 2 0/ 0 -WET RED MATERIAL AROUND MOUTH 0/ 0 1/ 1 0/ 0 1/ 1 0/ 0 -DRIED RED MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0

----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM PCSUv4.07 11/25/2013 R:01/20/2014**Page 76 of 1107**TABLE S5 (F0 FEMALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS

----- F E M A L E -----

----------------------------------------------------------------------------------------------------------------------------------- TABLE RANGE: 10-14-13 TO 12-05-13 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NORMAL -NO SIGNIFICANT CLINICAL OBSERVATIONS 71/12 84/12 79/12 87/12 58/11

DISPOSITION -SCHEDULED EUTHANASIA; LACTATION DAY 4 12/12 12/12 12/12 10/10 12/12 -SCHEDULED EUTHANASIA; TOTAL LITTER LOSS 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0 -SCHEDULED EUTHANASIA; POST-COHABITATION 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0 DAY 25

BODY/INTEGUMENT -HAIR LOSS RIGHT FORELIMB 11/ 3 3/ 2 7/ 4 9/ 2 22/ 4 -HAIR LOSS LEFT FORELIMB 9/ 2 3/ 2 8/ 4 9/ 2 23/ 5 -HAIR LOSS VENTRAL ABDOMINAL AREA 6/ 2 0/ 0 0/ 0 0/ 0 5/ 1 -HAIR LOSS RIGHT INGUINAL AREA 1/ 1 0/ 0 0/ 0 0/ 0 4/ 1 -HAIR LOSS LEFT INGUINAL AREA 0/ 0 0/ 0 0/ 0 0/ 0 4/ 1 -HAIR LOSS LEFT HINDLIMB 0/ 0 0/ 0 0/ 0 0/ 0 5/ 1 -HAIR LOSS RIGHT HINDLIMB 0/ 0 0/ 0 0/ 0 0/ 0 3/ 2

EYES/EARS/NOSE -DRIED RED MATERIAL AROUND NOSE 0/ 0 1/ 1 1/ 1 1/ 1 0/ 0

SPECIAL II -BREEDING PERIOD COMPLETE; FEMALE 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0 SEPARATED FROM MALE AND PLACED INTO CLEAN CAGING

----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM PCSUv4.07 01/29/2014**Page 77 of 1107**TABLE S6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS

----- F E M A L E -----

----------------------------------------------------------------------------------------------------------------------------------- TABLE RANGE: 10-14-13 TO 11-20-13 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NORMAL -NO SIGNIFICANT CLINICAL OBSERVATIONS 0/ 0 0/ 0 0/ 0 0/ 0 176/12

BEHAVIOR/CNS -HYPOACTIVITY 0/ 0 0/ 0 0/ 0 0/ 0 12/12

BODY/INTEGUMENT -WET CLEAR MATERIAL RIGHT FORELIMB 0/ 0 0/ 0 0/ 0 0/ 0 13/ 2 -WET CLEAR MATERIAL LEFT FORELIMB 0/ 0 0/ 0 0/ 0 0/ 0 12/ 2 -WET CLEAR MATERIAL VENTRAL NECK 0/ 0 0/ 0 0/ 0 0/ 0 14/ 2

CARDIO-PULMONARY -DECREASED RESPIRATION 0/ 0 0/ 0 0/ 0 0/ 0 12/12

EYES/EARS/NOSE -DRIED RED MATERIAL AROUND NOSE 0/ 0 0/ 0 0/ 0 0/ 0 11/ 7 -WET RED MATERIAL AROUND NOSE 0/ 0 0/ 0 0/ 0 0/ 0 26/10 -EYELIDS COMPLETELY SHUT 0/ 0 0/ 0 0/ 0 0/ 0 12/12 -LACRIMATION RIGHT EYE 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1 -LACRIMATION 0/ 0 0/ 0 0/ 0 0/ 0 12/12

ORAL/DENTAL -WET CLEAR MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 0/ 0 180/12

----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM**Page 78 of 1107**TABLE S6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS

----- F E M A L E -----

----------------------------------------------------------------------------------------------------------------------------------- TABLE RANGE: 10-14-13 TO 11-20-13 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

ORAL/DENTAL -SALIVATION 0/ 0 0/ 0 0/ 0 0/ 0 127/12 -WET RED MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 0/ 0 19/ 7 -DRIED RED MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 0/ 0 6/ 3

----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM PCSUv4.07 01/24/2014 R:01/24/2014**Page 79 of 1107**TABLE S7 (F0 FEMALES - 1 HOUR POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS

----- F E M A L E -----

----------------------------------------------------------------------------------------------------------------------------------- TABLE RANGE: 10-14-13 TO 11-20-13 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NORMAL -NO SIGNIFICANT CLINICAL OBSERVATIONS 0/ 0 0/ 0 0/ 0 0/ 0 392/12

BODY/INTEGUMENT -WET CLEAR MATERIAL RIGHT FORELIMB 0/ 0 0/ 0 0/ 0 0/ 0 16/ 1 -WET CLEAR MATERIAL LEFT FORELIMB 0/ 0 0/ 0 0/ 0 0/ 0 17/ 1 -WET CLEAR MATERIAL VENTRAL NECK 0/ 0 0/ 0 0/ 0 0/ 0 18/ 1 -WET CLEAR MATERIAL VENTRAL ABDOMINAL 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1
AREA

EYES/EARS/NOSE -DRIED RED MATERIAL AROUND NOSE 0/ 0 0/ 0 0/ 0 0/ 0 13/ 7 -WET RED MATERIAL AROUND NOSE 0/ 0 0/ 0 0/ 0 0/ 0 2/ 1

ORAL/DENTAL -WET CLEAR MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 0/ 0 17/ 2 -WET RED MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 0/ 0 2/ 1 -DRIED RED MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 0/ 0 6/ 5

----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM PCSUv4.07 01/20/2014 R:01/20/2014**Page 80 of 1107**TABLE S8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS

----- F E M A L E -----

----------------------------------------------------------------------------------------------------------------------------------- TABLE RANGE: 10-14-13 TO 12-04-13 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NORMAL -NO SIGNIFICANT CLINICAL OBSERVATIONS 440/12 415/12 414/12 429/12 421/12

EYES/EARS/NOSE -DRIED RED MATERIAL AROUND NOSE 3/ 3 28/ 9 23/11 47/12 10/ 6 -WET RED MATERIAL AROUND NOSE 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0

ORAL/DENTAL -DRIED RED MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 0/ 0 2/ 2

----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM PCSUv4.07 01/20/2014 R:01/20/2014**Page 81 of 1107**TABLE S9 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF BODY WEIGHTS [G]

----------------------------------------------------------------------------------------------------------------------------------- MALES GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 0 MEAN 371. 372. 374. 370. 370. % DIFFERENCE 0.3 0.8 -0.3 -0.3 S.D. 16.0 19.9 17.7 16.5 18.6 S.E. 4.6 5.8 5.1 4.8 5.4 N 12 12 12 12 12

DAY 7 MEAN 387. 393. 386. 384. 375. % DIFFERENCE 1.6 -0.3 -0.8 -3.1 S.D. 17.3 22.2 13.7 20.0 19.1 S.E. 5.0 6.4 4.0 5.8 5.5 N 12 12 12 12 12

DAY 13 MEAN 407. 417. 401. 406. 387. % DIFFERENCE 2.5 -1.5 -0.2 -4.9 S.D. 21.2 23.2 16.0 19.8 23.3 S.E. 6.1 6.7 4.6 5.7 6.7 N 12 12 12 12 12

DAY 21 MEAN 424. 436. 415. 423. 404. % DIFFERENCE 2.8 -2.1 -0.2 -4.7 S.D. 25.1 28.2 16.0 17.1 23.6 S.E. 7.3 8.1 4.6 4.9 6.8 N 12 12 12 12 12

DAY 28 MEAN 448. 456. 431. 438. 418.* % DIFFERENCE 1.8 -3.8 -2.2 -6.7 S.D. 26.8 32.1 18.1 21.9 24.9 S.E. 7.7 9.3 5.2 6.3 7.2 N 12 12 12 12 12

----------------------------------------------------------------------------------------------------------------------------------- * = Significantly different from the control group at 0.05 using Dunnett's test PJTBWSUv5.20 11/25/2013**Page 82 of 1107**TABLE S10 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF BODY WEIGHT CHANGES [G]

----------------------------------------------------------------------------------------------------------------------------------- MALES GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 0- 7 MEAN 16. 20. 12. 14. 5.* S.D. 6.8 9.7 10.8 13.2 8.0 S.E. 2.0 2.8 3.1 3.8 2.3 N 12 12 12 12 12

DAY 7- 13 MEAN 20. 24. 16. 22. 12.* S.D. 6.7 5.3 9.2 6.3 7.5 S.E. 1.9 1.5 2.7 1.8 2.2 N 12 12 12 12 12

DAY 13- 21 MEAN 18. 20. 14. 17. 17. S.D. 8.9 6.2 6.9 10.1 6.4 S.E. 2.6 1.8 2.0 2.9 1.8 N 12 12 12 12 12

DAY 21- 28 MEAN 24. 20. 16.* 15.* 13.** S.D. 6.4 5.5 7.6 9.9 6.6 S.E. 1.8 1.6 2.2 2.9 1.9 N 12 12 12 12 12

DAY 0- 13 (PRE-MATING PERIOD) MEAN 36. 44. 27. 36. 17.** S.D. 10.1 12.8 16.9 15.1 10.1 S.E. 2.9 3.7 4.9 4.3 2.9 N 12 12 12 12 12

----------------------------------------------------------------------------------------------------------------------------------- * = Significantly different from the control group at 0.05 using Dunnett's test ** = Significantly different from the control group at 0.01 using Dunnett's test MEAN DIFFERENCES CALCULATED FROM INDIVIDUAL DIFFERENCES**Page 83 of 1107**TABLE S10 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF BODY WEIGHT CHANGES [G]

----------------------------------------------------------------------------------------------------------------------------------- MALES GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 0- 28 (ENTIRE TREATMENT PERIOD) MEAN 78. 84. 57.* 68. 48.** S.D. 17.5 19.1 15.1 19.7 12.4 S.E. 5.0 5.5 4.3 5.7 3.6 N 12 12 12 12 12

----------------------------------------------------------------------------------------------------------------------------------- * = Significantly different from the control group at 0.05 using Dunnett's test ** = Significantly different from the control group at 0.01 using Dunnett's test MEAN DIFFERENCES CALCULATED FROM INDIVIDUAL DIFFERENCES PJTBWSUv5.20 11/25/2013 R:01/07/2014**Page 84 of 1107**TABLE S11 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF BODY WEIGHTS [G]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 0 MEAN 252. 246. 243. 252. 246. % DIFFERENCE -2.4 -3.6 0.0 -2.4 S.D. 11.7 12.8 15.1 15.8 12.8 S.E. 3.4 3.7 4.4 4.6 3.7 N 12 12 12 12 12

DAY 7 MEAN 265. 262. 261. 264. 257. % DIFFERENCE -1.1 -1.5 -0.4 -3.0 S.D. 14.7 14.3 16.6 17.6 10.6 S.E. 4.2 4.1 4.8 5.1 3.1 N 12 12 12 12 12

DAY 13 MEAN 276. 275. 278. 282. 269. % DIFFERENCE -0.4 0.7 2.2 -2.5 S.D. 16.1 17.6 18.1 19.0 9.1 S.E. 4.7 5.1 5.2 5.5 2.6 N 12 12 12 12 12

----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group PJTBWSUv5.20 01/07/2014**Page 85 of 1107**TABLE S12 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF BODY WEIGHT CHANGES [G]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 0- 7 MEAN 14. 16. 18. 12. 12. S.D. 11.4 5.1 8.2 9.6 7.8 S.E. 3.3 1.5 2.4 2.8 2.3 N 12 12 12 12 12

DAY 7- 13 MEAN 10. 13. 16. 18. 11. S.D. 8.3 13.1 7.8 4.4 4.9 S.E. 2.4 3.8 2.2 1.3 1.4 N 12 12 12 12 12

DAY 0- 13 (PRE-MATING PERIOD) MEAN 24. 29. 35. 31. 23. S.D. 11.7 12.5 9.4 11.1 9.5 S.E. 3.4 3.6 2.7 3.2 2.7 N 12 12 12 12 12

----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group MEAN DIFFERENCES CALCULATED FROM INDIVIDUAL DIFFERENCES PJTBWSUv5.20 01/07/2014 R:01/07/2014**Page 86 of 1107**TABLE S13 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF BODY WEIGHTS DURING GESTATION [G]

GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 0 MEAN 277. 276. 279. 289. 269. % DIFFERENCE -0.4 0.7 4.3 -2.9 S.D. 18.1 15.7 21.5 27.1 8.5 S.E. 5.2 4.5 6.2 8.2 2.5 N 12 12 12 11 12

DAY 4 MEAN 302. 301. 302. 306. 292. % DIFFERENCE -0.3 0.0 1.3 -3.3 S.D. 16.4 12.9 21.5 23.7 9.9 S.E. 4.7 3.7 6.2 7.1 2.8 N 12 12 12 11 12

DAY 7 MEAN 314. 314. 314. 318. 303. % DIFFERENCE 0.0 0.0 1.3 -3.5 S.D. 18.3 14.9 22.6 27.7 11.8 S.E. 5.3 4.3 6.5 8.3 3.4 N 12 12 12 11 12

DAY 11 MEAN 336. 332. 332. 338. 323. % DIFFERENCE -1.2 -1.2 0.6 -3.9 S.D. 20.9 15.4 22.2 28.2 14.7 S.E. 6.0 4.4 6.4 8.5 4.2 N 12 12 12 11 12

DAY 14 MEAN 354. 346. 348. 349. 336. % DIFFERENCE -2.3 -1.7 -1.4 -5.1 S.D. 20.3 15.2 23.3 28.1 15.8 S.E. 5.9 4.4 6.7 8.5 4.6 N 12 12 12 11 12

----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group NONGRAVID WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 87 of 1107**TABLE S13 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF BODY WEIGHTS DURING GESTATION [G]

GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 17 MEAN 385. 378. 378. 380. 369. % DIFFERENCE -1.8 -1.8 -1.3 -4.2 S.D. 22.2 19.7 22.8 29.7 17.7 S.E. 6.4 5.7 6.6 9.0 5.1 N 12 12 12 11 12

DAY 20 MEAN 427. 425. 427. 430. 415. % DIFFERENCE -0.5 0.0 0.7 -2.8 S.D. 25.6 23.1 28.0 31.4 17.9 S.E. 7.4 6.7 8.1 9.5 5.2 N 12 12 12 11 12

----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group NONGRAVID WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN PGBWSUv5.10 01/07/2014**Page 88 of 1107**TABLE S14 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF BODY WEIGHT CHANGES DURING GESTATION [G]

GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 0- 4 MEAN 25. 24. 22. 17.* 24. S.D. 7.4 5.8 8.4 5.1 7.4 S.E. 2.1 1.7 2.4 1.6 2.1 N 12 12 12 11 12

DAY 4- 7 MEAN 12. 13. 12. 12. 10. S.D. 4.9 3.8 5.6 5.8 4.1 S.E. 1.4 1.1 1.6 1.7 1.2 N 12 12 12 11 12

DAY 7- 11 MEAN 21. 18. 18. 19. 20. S.D. 5.4 4.4 7.3 4.2 5.2 S.E. 1.6 1.3 2.1 1.3 1.5 N 12 12 12 11 12

DAY 11- 14 MEAN 18. 14. 16. 12.** 14.* S.D. 4.4 4.8 3.5 3.3 3.3 S.E. 1.3 1.4 1.0 1.0 0.9 N 12 12 12 11 12

DAY 14- 17 MEAN 32. 31. 31. 31. 33. S.D. 4.8 8.3 6.4 5.4 6.7 S.E. 1.4 2.4 1.9 1.6 1.9 N 12 12 12 11 12

----------------------------------------------------------------------------------------------------------------------------------- * = Significantly different from the control group at 0.05 using Dunnett's test ** = Significantly different from the control group at 0.01 using Dunnett's test MEAN DIFFERENCES CALCULATED FROM INDIVIDUAL DIFFERENCES NONGRAVID WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 89 of 1107**TABLE S14 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF BODY WEIGHT CHANGES DURING GESTATION [G]

GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 17- 20 MEAN 42. 48. 49. 51. 46. S.D. 5.3 6.5 12.2 6.8 5.0 S.E. 1.5 1.9 3.5 2.1 1.4 N 12 12 12 11 12

DAY 0- 20 MEAN 150. 149. 147. 141. 146. S.D. 17.9 12.9 22.1 10.2 16.6 S.E. 5.2 3.7 6.4 3.1 4.8 N 12 12 12 11 12

----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group MEAN DIFFERENCES CALCULATED FROM INDIVIDUAL DIFFERENCES NONGRAVID WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN PGBWSUv5.10 01/07/2014**Page 90 of 1107**TABLE S15 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF BODY WEIGHTS DURING LACTATION [G]

GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 1 MEAN 326. 316. 317. 326. 307. % DIFFERENCE -3.1 -2.8 0.0 -5.8 S.D. 28.2 23.7 26.0 29.1 18.7 S.E. 8.1 6.8 7.5 8.8 5.4 N 12 12 12 11 12

DAY 4 MEAN 342. 327. 326. 337. 326. % DIFFERENCE -4.4 -4.7 -1.5 -4.7 S.D. 22.6 23.5 28.3 33.2 17.9 S.E. 6.5 6.8 8.2 10.5 5.2 N 12 12 12 10 12

----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group PLBWSUv5.08 01/07/2014**Page 91 of 1107**TABLE S16 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF BODY WEIGHT CHANGES DURING LACTATION [G]

GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 1- 4 MEAN 16. 11. 8. 10. 20. S.D. 13.0 12.0 7.2 10.6 12.9 S.E. 3.8 3.5 2.1 3.4 3.7 N 12 12 12 10 12

----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group MEAN DIFFERENCES CALCULATED FROM INDIVIDUAL DIFFERENCES PLBWSUv5.08 01/07/2014**Page 92 of 1107**TABLE S17 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF FOOD CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- MALES GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 0- 7 MEAN 24. 24. 23. 22. 22.* S.D. 1.6 2.4 1.7 2.2 1.4 S.E. 0.5 0.7 0.5 0.6 0.4 N 12 12 12 12 12

DAY 7- 13 MEAN 23. 24. 22. 23. 21.** S.D. 1.4 2.3 1.9 1.9 1.7 S.E. 0.4 0.7 0.5 0.6 0.5 N 12 12 12 12 12

----------------------------------------------------------------------------------------------------------------------------------- * = Significantly different from the control group at 0.05 using Dunnett's test ** = Significantly different from the control group at 0.01 using Dunnett's test PJTFWSUv5.23 11/25/2013**Page 93 of 1107**TABLE S18 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF FOOD CONSUMPTION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- MALES GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 0- 7 MEAN 63. 62. 60. 59. 59. S.D. 4.2 3.7 4.8 4.6 2.9 S.E. 1.2 1.1 1.4 1.3 0.8 N 12 12 12 12 12

DAY 7- 13 MEAN 59. 59. 55.* 58. 54.** S.D. 2.5 3.4 4.2 3.1 2.4 S.E. 0.7 1.0 1.2 0.9 0.7 N 12 12 12 12 12

----------------------------------------------------------------------------------------------------------------------------------- * = Significantly different from the control group at 0.05 using Dunnett's test ** = Significantly different from the control group at 0.01 using Dunnett's test PJTFWSUv5.23 11/25/2013**Page 94 of 1107**TABLE S19 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF FOOD CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 0- 7 MEAN 18. 17. 17. 17.* 16.* S.D. 1.8 1.2 1.9 1.6 0.9 S.E. 0.5 0.3 0.5 0.5 0.3 N 12 12 12 12 12

DAY 7- 13 MEAN 19. 18. 19. 19. 18. S.D. 1.6 1.7 1.8 1.8 1.2 S.E. 0.5 0.5 0.5 0.5 0.3 N 12 12 12 12 12

----------------------------------------------------------------------------------------------------------------------------------- * = Significantly different from the control group at 0.05 using Dunnett's test PJTFWSUv5.23 01/07/2014**Page 95 of 1107**TABLE S20 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF FOOD CONSUMPTION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 0- 7 MEAN 71. 68. 68. 64.** 65.* S.D. 5.5 2.3 5.1 7.0 3.5 S.E. 1.6 0.7 1.5 2.0 1.0 N 12 12 12 12 12

DAY 7- 13 MEAN 70. 67. 70. 68. 67. S.D. 4.0 5.1 3.4 4.6 4.3 S.E. 1.2 1.5 1.0 1.3 1.2 N 12 12 12 12 12

----------------------------------------------------------------------------------------------------------------------------------- * = Significantly different from the control group at 0.05 using Dunnett's test ** = Significantly different from the control group at 0.01 using Dunnett's test PJTFWSUv5.23 01/07/2014**Page 96 of 1107**TABLE S21 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF FOOD CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 0- 4 MEAN 20. 20. 19. 18.* 19. S.D. 1.7 1.6 2.6 1.8 2.5 S.E. 0.5 0.5 0.7 0.5 0.7 N 12 12 12 11 12

DAY 4- 7 MEAN 22. 22. 22. 21. 21. S.D. 2.2 1.5 2.6 2.6 2.6 S.E. 0.6 0.4 0.7 0.8 0.7 N 12 12 12 11 12

DAY 7- 11 MEAN 24. 23. 23. 22. 21. S.D. 2.3 2.1 2.0 2.7 2.3 S.E. 0.7 0.6 0.6 0.8 0.7 N 12 12 12 11 12

DAY 11- 14 MEAN 25. 24. 23. 23. 22. S.D. 2.2 0.7 2.6 2.3 2.2 S.E. 0.6 0.2 0.7 0.7 0.6 N 12 12 12 11 12

DAY 14- 17 MEAN 26. 25. 25. 25. 25. S.D. 2.4 1.9 2.6 2.1 2.4 S.E. 0.7 0.5 0.7 0.6 0.7 N 12 12 12 11 12

----------------------------------------------------------------------------------------------------------------------------------- * = Significantly different from the control group at 0.05 using Dunnett's test NONGRAVID WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 97 of 1107**TABLE S21 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF FOOD CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 17- 20 MEAN 26. 26. 26. 27. 25. S.D. 2.3 2.4 2.6 2.5 2.5 S.E. 0.7 0.7 0.7 0.7 0.7 N 12 12 12 11 12

DAY 0- 20 MEAN 24. 23. 23. 22. 22. S.D. 1.8 1.2 2.0 2.2 2.3 S.E. 0.5 0.3 0.6 0.7 0.7 N 12 12 12 11 12

----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group NONGRAVID WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN PGFWSUv5.16 01/07/2014**Page 98 of 1107**TABLE S22 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF FOOD CONSUMPTION DURING GESTATION [G/KG/DAY]

GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 0- 4 MEAN 70. 69. 66. 60.** 66. S.D. 6.9 6.3 8.7 5.7 8.3 S.E. 2.0 1.8 2.5 1.7 2.4 N 12 12 12 11 12

DAY 4- 7 MEAN 72. 71. 73. 68. 70. S.D. 5.1 5.1 6.6 5.7 7.0 S.E. 1.5 1.5 1.9 1.7 2.0 N 12 12 12 11 12

DAY 7- 11 MEAN 73. 70. 70. 67. 68. S.D. 3.4 5.6 4.1 4.8 5.1 S.E. 1.0 1.6 1.2 1.5 1.5 N 12 12 12 11 12

DAY 11- 14 MEAN 71. 70. 68. 67. 68. S.D. 3.6 3.1 5.1 4.1 4.6 S.E. 1.0 0.9 1.5 1.2 1.3 N 12 12 12 11 12

DAY 14- 17 MEAN 71. 70. 70. 68. 71. S.D. 4.5 3.5 4.9 3.9 5.3 S.E. 1.3 1.0 1.4 1.2 1.5 N 12 12 12 11 12

----------------------------------------------------------------------------------------------------------------------------------- ** = Significantly different from the control group at 0.01 using Dunnett's test NONGRAVID WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 99 of 1107**TABLE S22 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF FOOD CONSUMPTION DURING GESTATION [G/KG/DAY]

GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 17- 20 MEAN 63. 66. 65. 67. 64. S.D. 3.5 4.1 4.5 4.2 5.6 S.E. 1.0 1.2 1.3 1.3 1.6 N 12 12 12 11 12

DAY 0- 20 MEAN 69. 68. 67. 65. 67. S.D. 3.2 2.7 4.0 4.3 5.6 S.E. 0.9 0.8 1.2 1.3 1.6 N 12 12 12 11 12

----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group NONGRAVID WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN PGFWSUv5.16 01/07/2014**Page 100 of 1107**TABLE S23 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF FOOD CONSUMPTION DURING LACTATION [G/ANIMAL/DAY]

GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 1- 4 MEAN 32. 30. 29. 28. 36. S.D. 6.7 5.1 8.1 6.4 4.7 S.E. 1.9 1.5 2.3 2.0 1.4 N 12 12 12 10 12

----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group PLFWSUv5.22 01/07/2014**Page 101 of 1107**TABLE S24 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF FOOD CONSUMPTION DURING LACTATION [G/KG/DAY]

GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 1- 4 MEAN 96. 92. 91. 83. 112. S.D. 19.1 14.0 22.2 16.5 15.6 S.E. 5.5 4.0 6.4 5.2 4.5 N 12 12 12 10 12

----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group PLFWSUv5.22 01/07/2014**Page 102 of 1107**TABLE S25 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- MALES GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 0- 7 MEAN 42. 40. 38. 45. 39. S.D. 8.6 7.9 6.0 11.2 7.6 S.E. 2.5 2.3 1.7 3.2 2.2 N 12 12 12 12 12

DAY 7- 13 MEAN 37. 38. 36. 41. 38. S.D. 4.7 4.2 4.4 7.4 6.9 S.E. 1.4 1.2 1.3 2.1 2.0 N 12 12 12 12 12

----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group PJTFWSUv5.23 01/20/2014**Page 103 of 1107**TABLE S26 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF WATER CONSUMPTION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- MALES GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 0- 7 MEAN 111. 104. 101. 119. 103. S.D. 21.9 19.1 16.4 31.3 18.0 S.E. 6.3 5.5 4.7 9.0 5.2 N 12 12 12 12 12

DAY 7- 13 MEAN 94. 93. 92. 105. 98. S.D. 11.6 9.6 11.5 19.6 14.7 S.E. 3.4 2.8 3.3 5.7 4.3 N 12 12 12 12 12

----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group PJTFWSUv5.23 01/20/2014**Page 104 of 1107**TABLE S27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 0- 7 MEAN 33. 33. 35. 37. 31. S.D. 6.1 7.4 5.7 7.0 4.8 S.E. 1.7 2.1 1.6 2.0 1.4 N 12 12 12 12 12

DAY 7- 13 MEAN 35. 35. 40. 38. 33. S.D. 6.6 8.9 7.2 5.4 3.9 S.E. 1.9 2.6 2.1 1.6 1.1 N 12 12 12 12 12

----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group PJTFWSUv5.23 01/16/2014**Page 105 of 1107**TABLE S28 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF WATER CONSUMPTION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 0- 7 MEAN 129. 132. 140. 143. 123. S.D. 23.5 32.9 24.3 26.6 21.7 S.E. 6.8 9.5 7.0 7.7 6.3 N 12 12 12 12 12

DAY 7- 13 MEAN 131. 130. 147. 138. 125. S.D. 26.3 37.8 28.8 17.4 17.7 S.E. 7.6 10.9 8.3 5.0 5.1 N 12 12 12 12 12

----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group PJTFWSUv5.23 01/16/2014**Page 106 of 1107**TABLE S29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 0- 4 MEAN 32. 34. 37. 38. 32. S.D. 3.1 5.3 7.8 5.8 3.5 S.E. 0.9 1.5 2.2 1.7 1.0 N 12 12 12 11 12

DAY 4- 7 MEAN 35. 36. 43.** 43.** 35. S.D. 3.1 6.0 6.9 5.9 3.9 S.E. 0.9 1.7 2.0 1.8 1.1 N 12 12 12 11 12

DAY 7- 11 MEAN 39. 37. 43. 46. 35. S.D. 7.0 6.3 6.9 7.7 3.6 S.E. 2.0 1.8 2.0 2.3 1.0 N 12 12 12 11 12

DAY 11- 14 MEAN 42. 42. 48. 52.** 41. S.D. 7.8 6.5 6.3 6.8 4.0 S.E. 2.2 1.9 1.8 2.1 1.2 N 12 12 12 11 12

DAY 14- 17 MEAN 47. 47. 53. 58.** 46. S.D. 8.9 7.9 6.4 8.3 5.1 S.E. 2.6 2.3 1.8 2.5 1.5 N 12 12 12 11 12

----------------------------------------------------------------------------------------------------------------------------------- ** = Significantly different from the control group at 0.01 using Dunnett's test NONGRAVID WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 107 of 1107**TABLE S29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 17- 20 MEAN 46. 47. 51. 58.** 45. S.D. 5.9 6.9 5.3 9.0 4.0 S.E. 1.7 2.0 1.5 2.7 1.2 N 12 12 12 11 12

DAY 0- 20 MEAN 40. 40. 45. 48.** 39. S.D. 4.3 5.9 6.1 6.6 3.4 S.E. 1.3 1.7 1.8 2.0 1.0 N 12 12 12 11 12

----------------------------------------------------------------------------------------------------------------------------------- ** = Significantly different from the control group at 0.01 using Dunnett's test NONGRAVID WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN PGFWSUv5.16 01/16/2014**Page 108 of 1107**TABLE S30 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF WATER CONSUMPTION DURING GESTATION [G/KG/DAY]

GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 0- 4 MEAN 112. 118. 128. 126. 114. S.D. 13.6 21.9 31.1 18.0 13.6 S.E. 3.9 6.3 9.0 5.4 3.9 N 12 12 12 11 12

DAY 4- 7 MEAN 114. 119. 140.** 139.** 116. S.D. 11.7 23.0 25.3 14.7 13.9 S.E. 3.4 6.6 7.3 4.4 4.0 N 12 12 12 11 12

DAY 7- 11 MEAN 121. 115. 133. 139. 113. S.D. 23.4 22.3 22.4 17.7 13.4 S.E. 6.8 6.4 6.5 5.3 3.9 N 12 12 12 11 12

DAY 11- 14 MEAN 123. 124. 143. 152.** 126. S.D. 25.2 22.4 17.9 16.3 15.3 S.E. 7.3 6.5 5.2 4.9 4.4 N 12 12 12 11 12

DAY 14- 17 MEAN 129. 130. 147. 160.** 130. S.D. 23.8 23.9 17.5 18.8 17.7 S.E. 6.9 6.9 5.0 5.7 5.1 N 12 12 12 11 12

----------------------------------------------------------------------------------------------------------------------------------- ** = Significantly different from the control group at 0.01 using Dunnett's test NONGRAVID WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 109 of 1107**TABLE S30 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF WATER CONSUMPTION DURING GESTATION [G/KG/DAY]

GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 17- 20 MEAN 113. 118. 126. 143.** 116. S.D. 15.0 18.8 14.1 17.1 11.9 S.E. 4.3 5.4 4.1 5.1 3.4 N 12 12 12 11 12

DAY 0- 20 MEAN 117. 119. 133. 140.** 117. S.D. 14.5 20.2 19.9 14.3 12.6 S.E. 4.2 5.8 5.7 4.3 3.6 N 12 12 12 11 12

----------------------------------------------------------------------------------------------------------------------------------- ** = Significantly different from the control group at 0.01 using Dunnett's test NONGRAVID WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN PGFWSUv5.16 01/16/2014**Page 110 of 1107**TABLE S31 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF WATER CONSUMPTION DURING LACTATION [G/ANIMAL/DAY]

GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 1- 4 MEAN 61. 48.* 48.* 46.** 51. S.D. 15.1 6.7 9.1 13.5 5.9 S.E. 4.3 1.9 2.6 4.3 1.7 N 12 12 12 10 12

----------------------------------------------------------------------------------------------------------------------------------- * = Significantly different from the control group at 0.05 using Dunnett's test ** = Significantly different from the control group at 0.01 using Dunnett's test PLFWSUv5.22 01/16/2014**Page 111 of 1107**TABLE S32 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF WATER CONSUMPTION DURING LACTATION [G/KG/DAY]

GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAY 1- 4 MEAN 183. 150. 148.* 139.** 160. S.D. 48.9 19.8 22.2 36.8 21.5 S.E. 14.1 5.7 6.4 11.6 6.2 N 12 12 12 10 12

----------------------------------------------------------------------------------------------------------------------------------- * = Significantly different from the control group at 0.05 using Dunnett's test ** = Significantly different from the control group at 0.01 using Dunnett's test PLFWSUv5.22 01/16/2014**Page 112 of 1107**TABLE S33 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ESTROUS CYCLE DATA

----------------------------------------------------------------------------------------------------------------------------------- FEMALES GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

ESTROUS CYCLE LENGTH (DAYS) MEAN 5.2 4.6 4.9 5.0 5.1 S.D. 2.41 0.50 0.42 1.05 1.67 S.E. 0.70 0.14 0.12 0.30 0.50 N 12 12 12 12 11

----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group ESTROUS CYCLE LENGTH CALCULATED FOR FEMALES HAVING ONE FULL ESTROUS CYCLE PCYCv5.29 01/07/2014**Page 113 of 1107**TABLE S34 (F0)

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROMO-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF REPRODUCTIVE PERFORMANCE

---------------------------------------------------------------------------------------------------------------------------------- DOSE GROUP 1 2 3 4 5

---------------------------------------------------------------------------------------------------------------------------------- NO. % NO. % NO. % NO. % NO. %

MALES ON STUDY 12 12 12 12 12

MALES THAT DIED 0 0 0 0 0

MALES PAIRED FOR MATING 12 12 12 12 12

MALES WITH EVIDENCE OF MATING 12 100.0 12 100.0 12 100.0 11 91.7 12 100.0 NO. THAT SIRED A LITTER 12 100.0 12 100.0 12 100.0 11 100.0 12 100.0 NO. THAT DID NOT SIRE A LITTER 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0

MALES WITH NO EVIDENCE OF MATING 0 0.0 0 0.0 0 0.0 1 8.3 0 0.0 NO. THAT SIRED A LITTER NA NA NA 0 0.0 NA NO. THAT DID NOT SIRE A LITTER NA NA NA 1 100.0 NA

---------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM NOTE: MALES WERE CONSIDERED TO HAVE SIRED A LITTER IF THE PAIRED FEMALE WAS GRAVID NOTE: POSITIVE EVIDENCE OF MATING DURING THE BREEDING PERIOD WAS CONFIRMED BY THE PRESENCE OF SPERM IN A VAGINAL LAVAGE OR A VAGINAL COPULATORY PLUG NA = NOT APPLICABLE**Page 114 of 1107**TABLE S34 (F0)

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROMO-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF REPRODUCTIVE PERFORMANCE

---------------------------------------------------------------------------------------------------------------------------------- DOSE GROUP 1 2 3 4 5

---------------------------------------------------------------------------------------------------------------------------------- NO. % NO. % NO. % NO. % NO. %

FEMALES ON STUDY 12 12 12 12 12

FEMALES THAT DIED 0 0 0 0 0

FEMALES PAIRED FOR MATING 12 12 12 12 12 NONGRAVID 0 0.0 0 0.0 0 0.0 1 8.3 0 0.0 GRAVID 12 100.0 12 100.0 12 100.0 11 91.7 12 100.0 DELIVERED 12 100.0 12 100.0 12 100.0 11 100.0 12 100.0 FEMALES WITH TOTAL LITTER LOSS 0 0.0 0 0.0 0 0.0 1 9.1 0 0.0 FEMALES WITH VIABLE PUPS 12 100.0 12 100.0 12 100.0 10 90.9 12 100.0 FAILED TO DELIVER 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0

FEMALES WITH EVIDENCE OF MATING 12 100.0 12 100.0 12 100.0 11 91.7 12 100.0 NO. GRAVID 12 100.0 12 100.0 12 100.0 11 100.0 12 100.0 NO. NONGRAVID 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0

FEMALES WITH NO EVIDENCE OF MATING 0 0.0 0 0.0 0 0.0 1 8.3 0 0.0 NO. GRAVID NA NA NA 0 0.0 NA NO. NONGRAVID NA NA NA 1 100.0 NA

TOTAL FEMALES GRAVID 12 100.0 12 100.0 12 100.0 11 91.7 12 100.0

---------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM NOTE: POSITIVE EVIDENCE OF MATING DURING THE BREEDING PERIOD WAS CONFIRMED BY THE PRESENCE OF SPERM IN A VAGINAL LAVAGE OR A VAGINAL COPULATORY PLUG. NA = NOT APPLICABLE**Page 115 of 1107**TABLE S34 (F0)

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROMO-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF REPRODUCTIVE PERFORMANCE

---------------------------------------------------------------------------------------------------------------------------------- DOSE GROUP 1 2 3 4 5

---------------------------------------------------------------------------------------------------------------------------------- NO. % NO. % NO. % NO. % NO. %

MALE MATING INDEX 12/12 100.0 12/12 100.0 12/12 100.0 11/12 91.7 12/12 100.0 FEMALE MATING INDEX 12/12 100.0 12/12 100.0 12/12 100.0 11/12 91.7 12/12 100.0

MALE FERTILITY INDEX 12/12 100.0 12/12 100.0 12/12 100.0 11/12 91.7 12/12 100.0 FEMALE FERTILITY INDEX 12/12 100.0 12/12 100.0 12/12 100.0 11/12 91.7 12/12 100.0

MALE COPULATION INDEX 12/12 100.0 12/12 100.0 12/12 100.0 11/11 100.0 12/12 100.0 FEMALE CONCEPTION INDEX 12/12 100.0 12/12 100.0 12/12 100.0 11/11 100.0 12/12 100.0

MEAN PRE-COITAL INTERVALS DAYS 2.9 NA 2.9 NA 2.4 NA 4.5 NA 2.0 NA S.D. 1.16 NA 1.62 NA 1.62 NA 3.78 NA 1.04 NA S.E. 0.34 NA 0.47 NA 0.47 NA 1.14 NA 0.30 NA N 12 NA 12 NA 12 NA 11 NA 12 NA

NO. OF MALES (FEMALES) WITH EVIDENCE OF MATING (OR CONFIRMED PREGNANCY) MALE (FEMALE) MATING INDEX (%) = ---------------------------------------------------------------------- X 100 TOTAL NO. OF MALES (FEMALES) USED FOR MATING

NO. OF MALES SIRING A LITTER MALE FERTILITY INDEX (%) = ----------------------------------------- X 100 TOTAL NO. OF MALES USED FOR MATING

NO. OF FEMALES WITH CONFIRMED PREGNANCY FEMALE FERTILITY INDEX (%) = ---------------------------------------- X 100 TOTAL NO. OF FEMALES USED FOR MATING

NO. OF MALES SIRING A LITTER MALE COPULATION INDEX (%) = ---------------------------------------------------------------------- X 100 NO. OF MALES WITH EVIDENCE OF MATING (OR FEMALES CONFIRMED PREGNANT)

NO. OF FEMALES WITH CONFIRMED PREGNANCY FEMALE CONCEPTION INDEX (%) = ----------------------------------------------------------------- X 100 NO. OF FEMALES WITH EVIDENCE OF MATING (OR CONFIRMED PREGNANCY)

--------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM PRE-COITAL INTERVALS NOT SIGNIFICANTLY DIFFERENT FROM CONTROL GROUP USING DUNNETT'S TEST MATING, FERTILITY AND COPULATION/CONCEPTION INDICES NOT SIGNIFICANTLY DIFFERENT FROM CONTROL GROUP USING CHI-SQUARE TEST NA = NOT APPLICABLE MANUALv1.0 12/13/2013 R:01/20/2014**Page 116 of 1107**TABLE S35 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF GESTATION LENGTHS [DAYS]

GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- GESTATION LENGTH (DAYS) MEAN 21.7 22.1 22.3** 22.6** 22.1 S.D. 0.49 0.29 0.49 0.50 0.29 S.E. 0.14 0.08 0.14 0.15 0.08 N 12 12 12 11 12

----------------------------------------------------------------------------------------------------------------------------------- ** = Significantly different from the control group at 0.01 using Dunnett's test PGLv5.10 01/07/2014**Page 117 of 1107**TABLE S36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF PARTURITION FINDINGS: TOTAL OCCURRENCE/NO. OF FEMALES

CATEGORY FINDING GROUP: 1 2 3 4 5

----------------------------------------------------------------------------------------------------------------------------------- PARTURITION OBS NO PRE-DELIVERY FINDINGS 47/ 12 60/ 12 62/ 12 99/ 12 58/ 12 VAGINAL DISCHARGE/MATERIAL 0/ 0 0/ 0 2/ 2 2/ 2 0/ 0 PUPS PRESENT IN NESTING BOX 12/ 12 12/ 12 12/ 12 11/ 11 12/ 12 NO SIGNIFICANT FINDINGS DURING PARTURITION 17/ 12 16/ 12 14/ 12 15/ 11 13/ 12

----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM PPOCRDv1.05 01/07/2014**Page 118 of 1107**TABLE S37 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF SPERM MOTILITY AND CONCENTRATION

GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- MOTILITY (%) MEAN 77. 75. 74. 80. 77. S.D. 6.5 5.5 7.8 4.9 9.8 S.E. 1.9 1.6 2.2 1.4 2.8 N 12 12 12 12 12

PROGRESSIVE MOTILITY (%) MEAN 59. 60. 59. 63. 61. S.D. 7.6 6.4 7.7 5.6 9.4 S.E. 2.2 1.8 2.2 1.6 2.7 N 12 12 12 12 12

CAUDA EPID, LT WEIGHT (GRAMS) MEAN 0.2824 0.2950 0.2784 0.2789 0.2791 S.D. 0.01902 0.02576 0.02161 0.02832 0.02835 S.E. 0.00549 0.00744 0.00624 0.00817 0.00819 N 12 12 12 12 12

CAUDA EPID, LT CONCENTRATION (MILLIONS/GRAM) MEAN 663.7 635.8 647.6 596.0 627.5 S.D. 165.40 161.90 140.33 191.92 207.96 S.E. 47.75 46.74 40.51 55.40 60.03 N 12 12 12 12 12

TESTIS, LT WEIGHT (GRAMS) MEAN 1.65 1.69 1.66 1.66 1.67 S.D. 0.076 0.119 0.136 0.115 0.140 S.E. 0.022 0.034 0.039 0.033 0.040 N 12 12 12 12 12

TESTIS, LT CONCENTRATION (MILLIONS/GRAM) MEAN 100.3 100.0 103.5 105.5 97.9 S.D. 13.34 22.38 15.80 17.04 12.00 S.E. 3.85 6.46 4.56 4.92 3.46 N 12 12 12 12 12

----------------------------------------------------------------------------------------------------------------------------------- MODIFIED STATISTICS USED. * INDICATES PARAMETRIC ANALYSIS AND + INDICATES NON-PARAMETRIC ANALYSIS. None significantly different from control group**Page 119 of 1107**TABLE S37 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF SPERM MOTILITY AND CONCENTRATION

GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- SPERM PRODUCTION RATE (MILLIONS/GRAM/DAY) MEAN 16.4 16.4 17.0 17.3 16.1 S.D. 2.19 3.67 2.59 2.79 1.97 S.E. 0.63 1.06 0.75 0.81 0.57 N 12 12 12 12 12

----------------------------------------------------------------------------------------------------------------------------------- MODIFIED STATISTICS USED. * INDICATES PARAMETRIC ANALYSIS AND + INDICATES NON-PARAMETRIC ANALYSIS. None significantly different from control group PDIVOSv4.30 01/20/2014**Page 120 of 1107**TABLE S38 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF SPERM MORPHOLOGY DIFFERENTIAL COUNTS [PERCENTAGE]

----------------------------------------------------------------------------------------------------------------------------------- ----- M A L E ----- GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- NORMAL MEAN 99.0 100.0 99.3 99.9 99.4 S.D. 1.75 0.14 1.34 0.23 0.83 S.E. 0.51 0.04 0.39 0.07 0.24 N 12 12 12 12 12

NORMALLY SHAPED HEAD SEPARATED FROM FLAGELLUM MEAN 0.7 0.0 0.4 0.0 0.3 S.D. 1.45 0.14 0.74 0.00 0.62 S.E. 0.42 0.04 0.21 0.00 0.18 N 12 12 12 12 12

HEAD ABSENT WITH NORMAL FLAGELLUM MEAN 0.3 0.0 0.3 0.1 0.3 S.D. 0.45 0.00 0.62 0.23 0.49 S.E. 0.13 0.00 0.18 0.07 0.14 N 12 12 12 12 12

HEAD ABSENT WITH ABNORMAL FLAGELLUM MEAN 0.0 0.0 0.0 0.0 0.0 S.D. 0.00 0.00 0.00 0.00 0.00 S.E. 0.00 0.00 0.00 0.00 0.00 N 12 12 12 12 12

MISSHAPEN HEAD WITH NORMAL FLAGELLUM MEAN 0.0 0.0 0.0 0.0 0.0 S.D. 0.00 0.00 0.00 0.00 0.00 S.E. 0.00 0.00 0.00 0.00 0.00 N 12 12 12 12 12

----------------------------------------------------------------------------------------------------------------------------------- MODIFIED STATISTICS USED. Percent of normal sperm not significantly different from control group**Page 121 of 1107**TABLE S38 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF SPERM MORPHOLOGY DIFFERENTIAL COUNTS [PERCENTAGE]

----------------------------------------------------------------------------------------------------------------------------------- ----- M A L E ----- GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- MISSHAPEN HEAD WITH ABNORMAL FLAGELLUM MEAN 0.0 0.0 0.0 0.0 0.0 S.D. 0.00 0.00 0.00 0.00 0.00 S.E. 0.00 0.00 0.00 0.00 0.00 N 12 12 12 12 12

FLAGELLAR DEFECTS WITH NORMAL HEAD MEAN 0.0 0.0 0.0 0.0 0.0 S.D. 0.00 0.00 0.00 0.00 0.00 S.E. 0.00 0.00 0.00 0.00 0.00 N 12 12 12 12 12

-----------------------------------------------------------------------------------------------------------------------------------

MANUALv1.0 11/14/2013 R:01/20/2014**Page 122 of 1107**TABLE S39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF MACROSCOPIC FINDINGS

SCHEDULED NECROPSY

----------------------------------------------------------------------------------------------------------------------------------- ----- M A L E ----- GROUP: 1 2 3 4 5

----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 12 12 12 12 12

KIDNEYS -DILATED PELVIS 1 1 0 0 1 -AREA(S), DEPRESSED 0 0 0 1 1

LN, MANDIBULAR -ENLARGED 0 0 0 0 1

SKIN -MATTING, RED 0 0 1 0 0

SPLEEN -AREA(S), WHITE 0 0 0 1 0

TEETH -MALALIGNED 0 0 1 0 0

NO SIGNIFICANT CHANGES OBSERVED - ALL EXAMINED TISSUES 11 11 11 10 9

----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM PGRSI2v4.11 02/18/2014**Page 123 of 1107**TABLE S40 (F0 FEMALES - FAILED TO DELIVER)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF MACROSCOPIC FINDINGS

SCHEDULED NECROPSY

----------------------------------------------------------------------------------------------------------------------------------- ----- F E M A L E ----- GROUP: 1 2 3 4 5

----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 0 0 0 1 0

UTERUS -CONTENTS, CLEAR FLUID 0 0 0 1 0

----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM PGRSI2v4.11 02/18/2014**Page 124 of 1107**TABLE S41 (F0 FEMALES - TOTAL LITTER LOSS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF MACROSCOPIC FINDINGS

SCHEDULED NECROPSY

----------------------------------------------------------------------------------------------------------------------------------- ----- F E M A L E ----- GROUP: 1 2 3 4 5

----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 0 0 0 1 0

NO SIGNIFICANT CHANGES OBSERVED - ALL EXAMINED TISSUES 0 0 0 1 0

----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM PGRSI2v4.11 02/18/2014**Page 125 of 1107**TABLE S42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF MACROSCOPIC FINDINGS

SCHEDULED NECROPSY

----------------------------------------------------------------------------------------------------------------------------------- ----- F E M A L E ----- GROUP: 1 2 3 4 5

----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 12 12 12 10 12

KIDNEYS -PALE 0 1 0 0 0

SPLEEN -ADHESIONS 0 0 1 1 0

NO SIGNIFICANT CHANGES OBSERVED - ALL EXAMINED TISSUES 12 11 11 9 12

----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM PGRSI2v4.11 02/18/2014**Page 126 of 1107**TABLE S43 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF CORPORA LUTEA AND IMPLANTATION SITES

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- IMPLANTATION SITES MEAN 15.8 14.3 14.4 15.3 15.1 S.D. 1.19 1.83 2.75 1.74 0.94 S.E. 0.34 0.53 0.79 0.52 0.28 N 12 12 12 11 11-A

NUMBER BORN MEAN 14.3 13.8 13.7 13.3 13.9 S.D. 1.78 2.12 2.96 2.10 1.24 S.E. 0.51 0.61 0.86 0.63 0.36 N 12 12 12 11 12

UNACCOUNTED SITES MEAN 1.5 0.5 0.8 2.0 1.1 S.D. 1.93 0.80 1.14 1.26 1.30 S.E. 0.56 0.23 0.33 0.38 0.39 N 12 12 12 11 11-A

CORPORA LUTEA MEAN 16.5 15.3 15.8 16.2 16.4 S.D. 1.62 1.30 1.29 1.89 1.63 S.E. 0.47 0.38 0.37 0.57 0.49 N 12 12 12 11 11-A

----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group NOTE: ONLY DAMS THAT HAVE DELIVERED ONE OR MORE PUPS ARE INCLUDED IN CALCULATION OF MEAN. A = NUMBER OF PUPS BORN EXCEEDED NUMBER OF IMPLANTATION SITES FOR 1 FEMALE; NOT INCLUDED IN CALCULATION OF MEAN. PISSUv5.12 01/07/2014 R:01/21/2014**Page 127 of 1107**TABLE S44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS

----------------------------------------------------------------------------------------------------------------------------------- MALES GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- FINAL BODY WT (G) MEAN 450. 456. 431. 438. 418.* % DIFFERENCE 1.3 -4.2 -2.7 -7.1 S.D. 27.2 32.3 18.1 21.4 23.8 S.E. 7.9 9.3 5.2 6.2 6.9 N 12 12 12 12 12

BRAIN (G) MEAN 2.12 2.04 2.05 2.02 2.05 % DIFFERENCE -3.8 -3.3 -4.7 -3.3 S.D. 0.104 0.107 0.069 0.073 0.107 S.E. 0.030 0.031 0.020 0.021 0.031 N 12 12 12 12 12

BRAIN (G/100 G FINAL BODY WEIGHT) MEAN 0.472 0.449 0.476 0.461 0.490 S.D. 0.0173 0.0329 0.0240 0.0244 0.0331 S.E. 0.0050 0.0095 0.0069 0.0070 0.0096 N 12 12 12 12 12

CAUDA EPID, LT (G) MEAN 0.2824 0.2950 0.2784 0.2789 0.2791 % DIFFERENCE 4.5 -1.4 -1.2 -1.2 S.D. 0.01902 0.02576 0.02161 0.02832 0.02835 S.E. 0.00549 0.00744 0.00624 0.00817 0.00819 N 12 12 12 12 12

----------------------------------------------------------------------------------------------------------------------------------- * = Significantly different from the control group at 0.05 using Dunnett's test**Page 128 of 1107**TABLE S44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS

----------------------------------------------------------------------------------------------------------------------------------- MALES GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- CAUDA EPID, LT (G/100 G FINAL BODY WEIGHT) MEAN 0.063 0.065 0.065 0.064 0.067 S.D. 0.0045 0.0053 0.0049 0.0054 0.0083 S.E. 0.0013 0.0015 0.0014 0.0016 0.0024 N 12 12 12 12 12

CAUDA EPID, LT (G/100 G BRAIN) MEAN 13.318 14.483 13.629 13.851 13.697 S.D. 0.8245 1.1513 1.1505 1.4427 1.6613 S.E. 0.2380 0.3324 0.3321 0.4165 0.4796 N 12 12 12 12 12

CAUDA EPID, RT (G) MEAN 0.2741 0.2825 0.2679 0.2679 0.2640 % DIFFERENCE 3.1 -2.3 -2.3 -3.7 S.D. 0.01689 0.02346 0.02547 0.02396 0.02522 S.E. 0.00488 0.00677 0.00735 0.00692 0.00728 N 12 12 12 12 12

CAUDA EPID, RT (G/100 G FINAL BODY WEIGHT) MEAN 0.061 0.062 0.062 0.061 0.063 S.D. 0.0057 0.0056 0.0063 0.0049 0.0057 S.E. 0.0016 0.0016 0.0018 0.0014 0.0016 N 12 12 12 12 12

----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group**Page 129 of 1107**TABLE S44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS

----------------------------------------------------------------------------------------------------------------------------------- MALES GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- CAUDA EPID, RT (G/100 G BRAIN) MEAN 12.944 13.878 13.097 13.305 12.918 S.D. 1.0209 1.1520 1.1461 1.2467 1.1101 S.E. 0.2947 0.3326 0.3309 0.3599 0.3204 N 12 12 12 12 12

EPIDIDYMIS, LT (G) MEAN 0.59 0.62 0.59 0.61 0.60 % DIFFERENCE 5.1 0.0 3.4 1.7 S.D. 0.043 0.046 0.041 0.043 0.046 S.E. 0.012 0.013 0.012 0.012 0.013 N 12 12 12 12 12

EPIDIDYMIS, LT (G/100 G FINAL BODY WEIGHT) MEAN 0.131 0.135 0.137 0.139 0.144** S.D. 0.0090 0.0090 0.0104 0.0078 0.0131 S.E. 0.0026 0.0026 0.0030 0.0023 0.0038 N 12 12 12 12 12

EPIDIDYMIS, LT (G/100 G BRAIN) MEAN 27.809 30.280 28.804 30.271 29.501 S.D. 1.6660 2.6216 2.3345 2.4427 2.8392 S.E. 0.4809 0.7568 0.6739 0.7051 0.8196 N 12 12 12 12 12

----------------------------------------------------------------------------------------------------------------------------------- ** = Significantly different from the control group at 0.01 using Dunnett's test**Page 130 of 1107**TABLE S44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS

----------------------------------------------------------------------------------------------------------------------------------- MALES GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- EPIDIDYMIS, RT (G) MEAN 0.64 0.65 0.63 0.64 0.64 % DIFFERENCE 1.6 -1.6 0.0 0.0 S.D. 0.037 0.045 0.047 0.044 0.061 S.E. 0.011 0.013 0.013 0.013 0.018 N 12 12 12 12 12

EPIDIDYMIS, RT (G/100 G FINAL BODY WEIGHT) MEAN 0.142 0.143 0.147 0.145 0.153 S.D. 0.0107 0.0089 0.0119 0.0066 0.0157 S.E. 0.0031 0.0026 0.0034 0.0019 0.0045 N 12 12 12 12 12

EPIDIDYMIS, RT (G/100 G BRAIN) MEAN 30.121 32.081 30.897 31.584 31.224 S.D. 1.9371 2.6131 2.1427 2.3623 3.0796 S.E. 0.5592 0.7543 0.6186 0.6819 0.8890 N 12 12 12 12 12

KIDNEYS (G) MEAN 3.39 3.38 3.24 3.34 3.17 % DIFFERENCE -0.3 -4.4 -1.5 -6.5 S.D. 0.118 0.353 0.212 0.258 0.278 S.E. 0.034 0.102 0.061 0.075 0.080 N 12 12 12 12 12

----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group**Page 131 of 1107**TABLE S44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS

----------------------------------------------------------------------------------------------------------------------------------- MALES GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- KIDNEYS (G/100 G FINAL BODY WEIGHT) MEAN 0.755 0.743 0.754 0.764 0.759 S.D. 0.0484 0.0584 0.0470 0.0496 0.0709 S.E. 0.0140 0.0169 0.0136 0.0143 0.0205 N 12 12 12 12 12

KIDNEYS (G/100 G BRAIN) MEAN 159.754 166.352 158.858 166.229 154.983 S.D. 7.0004 18.7974 13.0893 15.4138 13.8028 S.E. 2.0209 5.4263 3.7786 4.4496 3.9845 N 12 12 12 12 12

LIVER (G) MEAN 15.81 16.38 15.30 15.57 14.44 % DIFFERENCE 3.6 -3.2 -1.5 -8.7 S.D. 1.142 2.090 1.107 1.142 1.426 S.E. 0.330 0.603 0.320 0.330 0.412 N 12 12 12 12 12

LIVER (G/100 G FINAL BODY WEIGHT) MEAN 3.519 3.585 3.552 3.558 3.459 S.D. 0.2123 0.2602 0.2047 0.1560 0.3457 S.E. 0.0613 0.0751 0.0591 0.0450 0.0998 N 12 12 12 12 12

----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group**Page 132 of 1107**TABLE S44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS

----------------------------------------------------------------------------------------------------------------------------------- MALES GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- LIVER (G/100 G BRAIN) MEAN 746.024 803.905 748.759 773.142 708.137 S.D. 56.6688 98.5677 60.6455 54.1115 83.4066 S.E. 16.3589 28.4540 17.5068 15.6206 24.0774 N 12 12 12 12 12

LUNGS (G) MEAN 1.66 1.71 1.69 1.80 1.64 % DIFFERENCE 3.0 1.8 8.4 -1.2 S.D. 0.165 0.170 0.102 0.162 0.153 S.E. 0.048 0.049 0.029 0.047 0.044 N 12 12 12 12 12

LUNGS (G/100 G FINAL BODY WEIGHT) MEAN 0.369 0.377 0.393 0.412** 0.392 S.D. 0.0283 0.0392 0.0288 0.0381 0.0260 S.E. 0.0082 0.0113 0.0083 0.0110 0.0075 N 12 12 12 12 12

LUNGS (G/100 G BRAIN) MEAN 78.054 84.096 82.718 89.466** 80.426 S.D. 5.7074 8.5177 6.6306 8.6495 7.8793 S.E. 1.6476 2.4588 1.9141 2.4969 2.2746 N 12 12 12 12 12

----------------------------------------------------------------------------------------------------------------------------------- ** = Significantly different from the control group at 0.01 using Dunnett's test**Page 133 of 1107**TABLE S44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS

----------------------------------------------------------------------------------------------------------------------------------- MALES GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- PITUITARY (G) MEAN 0.0156 0.0146 0.0126** 0.0127** 0.0133* % DIFFERENCE -6.4 -19.2 -18.6 -14.7 S.D. 0.00314 0.00203 0.00139 0.00113 0.00151 S.E. 0.00091 0.00059 0.00040 0.00033 0.00044 N 12 12 12 12 12

PITUITARY (G/100 G FINAL BODY WEIGHT) MEAN 0.003 0.003 0.003** 0.003** 0.003 S.D. 0.0007 0.0004 0.0003 0.0002 0.0004 S.E. 0.0002 0.0001 0.0001 0.0001 0.0001 N 12 12 12 12 12

PITUITARY (G/100 G BRAIN) MEAN 0.735 0.713 0.615** 0.632* 0.651 S.D. 0.1383 0.0795 0.0629 0.0595 0.0694 S.E. 0.0399 0.0230 0.0182 0.0172 0.0200 N 12 12 12 12 12

SPLEEN (G) MEAN 0.82 0.84 0.76 0.77 0.74 % DIFFERENCE 2.4 -7.3 -6.1 -9.8 S.D. 0.114 0.125 0.053 0.109 0.087 S.E. 0.033 0.036 0.015 0.031 0.025 N 12 12 12 12 12

----------------------------------------------------------------------------------------------------------------------------------- * = Significantly different from the control group at 0.05 using Dunnett's test ** = Significantly different from the control group at 0.01 using Dunnett's test**Page 134 of 1107**TABLE S44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS

----------------------------------------------------------------------------------------------------------------------------------- MALES GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- SPLEEN (G/100 G FINAL BODY WEIGHT) MEAN 0.181 0.183 0.177 0.177 0.176 S.D. 0.0170 0.0199 0.0130 0.0217 0.0156 S.E. 0.0049 0.0057 0.0037 0.0063 0.0045 N 12 12 12 12 12

SPLEEN (G/100 G BRAIN) MEAN 38.470 40.976 37.175 38.388 35.910 S.D. 4.5124 5.1303 2.4830 5.2915 3.3728 S.E. 1.3026 1.4810 0.7168 1.5275 0.9736 N 12 12 12 12 12

TESTIS, LT (G) MEAN 1.65 1.69 1.66 1.66 1.67 % DIFFERENCE 2.4 0.6 0.6 1.2 S.D. 0.076 0.119 0.136 0.115 0.140 S.E. 0.022 0.034 0.039 0.033 0.040 N 12 12 12 12 12

TESTIS, LT (G/100 G FINAL BODY WEIGHT) MEAN 0.368 0.371 0.387 0.380 0.401 S.D. 0.0224 0.0274 0.0315 0.0256 0.0382 S.E. 0.0065 0.0079 0.0091 0.0074 0.0110 N 12 12 12 12 12

----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group**Page 135 of 1107**TABLE S44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS

----------------------------------------------------------------------------------------------------------------------------------- MALES GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- TESTIS, LT (G/100 G BRAIN) MEAN 77.837 82.964 81.410 82.467 81.976 S.D. 3.8177 8.2986 7.0243 6.7831 7.3653 S.E. 1.1021 2.3956 2.0278 1.9581 2.1262 N 12 12 12 12 12

TESTIS, RT (G) MEAN 1.67 1.69 1.67 1.69 1.71 % DIFFERENCE 1.2 0.0 1.2 2.4 S.D. 0.092 0.125 0.123 0.111 0.133 S.E. 0.027 0.036 0.035 0.032 0.038 N 12 12 12 12 12

TESTIS, RT (G/100 G FINAL BODY WEIGHT) MEAN 0.372 0.371 0.388 0.385 0.409** S.D. 0.0267 0.0295 0.0289 0.0215 0.0347 S.E. 0.0077 0.0085 0.0083 0.0062 0.0100 N 12 12 12 12 12

TESTIS, RT (G/100 G BRAIN) MEAN 78.699 83.086 81.818 83.698 83.594 S.D. 4.4258 8.3680 6.4261 5.9026 6.8837 S.E. 1.2776 2.4156 1.8551 1.7039 1.9871 N 12 12 12 12 12

----------------------------------------------------------------------------------------------------------------------------------- ** = Significantly different from the control group at 0.01 using Dunnett's test POFBSTv5.26 11/25/2013 R:01/17/2014**Page 136 of 1107**TABLE S45 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS

----------------------------------------------------------------------------------------------------------------------------------- FEMALES GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- FINAL BODY WT (G) MEAN 342. 327. 326. 337. 326. % DIFFERENCE -4.4 -4.7 -1.5 -4.7 S.D. 22.6 23.5 28.3 33.2 17.9 S.E. 6.5 6.8 8.2 10.5 5.2 N 12 12 12 10 12

BRAIN (G) MEAN 1.98 1.96 1.92 1.99 1.97 % DIFFERENCE -1.0 -3.0 0.5 -0.5 S.D. 0.056 0.094 0.060 0.085 0.081 S.E. 0.016 0.027 0.017 0.027 0.023 N 12 12 12 10 12

BRAIN (G/100 G FINAL BODY WEIGHT) MEAN 0.580 0.600 0.595 0.594 0.606 S.D. 0.0307 0.0424 0.0550 0.0452 0.0335 S.E. 0.0089 0.0122 0.0159 0.0143 0.0097 N 12 12 12 10 12

KIDNEYS (G) MEAN 2.31 2.30 2.25 2.33 2.25 % DIFFERENCE -0.4 -2.6 0.9 -2.6 S.D. 0.094 0.194 0.254 0.186 0.282 S.E. 0.027 0.056 0.073 0.059 0.081 N 12 12 12 10 12

----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group**Page 137 of 1107**TABLE S45 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS

----------------------------------------------------------------------------------------------------------------------------------- FEMALES GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- KIDNEYS (G/100 G FINAL BODY WEIGHT) MEAN 0.675 0.704 0.690 0.694 0.689 S.D. 0.0460 0.0411 0.0463 0.0564 0.0745 S.E. 0.0133 0.0119 0.0134 0.0178 0.0215 N 12 12 12 10 12

KIDNEYS (G/100 G BRAIN) MEAN 116.444 117.941 116.960 117.325 114.155 S.D. 4.4814 10.8749 14.2743 11.2889 14.4209 S.E. 1.2937 3.1393 4.1206 3.5699 4.1630 N 12 12 12 10 12

LIVER (G) MEAN 14.57 13.81 13.58 14.44 13.66 % DIFFERENCE -5.2 -6.8 -0.9 -6.2 S.D. 1.569 1.384 1.366 1.153 0.922 S.E. 0.453 0.399 0.394 0.365 0.266 N 12 12 12 10 12

LIVER (G/100 G FINAL BODY WEIGHT) MEAN 4.254 4.217 4.173 4.296 4.185 S.D. 0.3456 0.2451 0.2540 0.1690 0.1934 S.E. 0.0998 0.0708 0.0733 0.0535 0.0558 N 12 12 12 10 12

----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group**Page 138 of 1107**TABLE S45 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS

----------------------------------------------------------------------------------------------------------------------------------- FEMALES GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- LIVER (G/100 G BRAIN) MEAN 735.127 706.773 706.734 725.824 692.981 S.D. 67.2134 66.6586 77.3444 42.2679 52.1833 S.E. 19.4028 19.2427 22.3274 13.3663 15.0640 N 12 12 12 10 12

LUNGS (G) MEAN 1.46 1.53 1.50 1.54 1.44 % DIFFERENCE 4.8 2.7 5.5 -1.4 S.D. 0.152 0.145 0.146 0.087 0.118 S.E. 0.044 0.042 0.042 0.027 0.034 N 12 12 12 10 12

LUNGS (G/100 G FINAL BODY WEIGHT) MEAN 0.429 0.469 0.462 0.461 0.441 S.D. 0.0471 0.0375 0.0470 0.0430 0.0323 S.E. 0.0136 0.0108 0.0136 0.0136 0.0093 N 12 12 12 10 12

LUNGS (G/100 G BRAIN) MEAN 73.944 78.495 77.949 77.709 72.862 S.D. 7.3575 7.0716 7.5488 4.9928 4.9068 S.E. 2.1239 2.0414 2.1791 1.5789 1.4165 N 12 12 12 10 12

----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group**Page 139 of 1107**TABLE S45 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS

----------------------------------------------------------------------------------------------------------------------------------- FEMALES GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- OVARIES (G) MEAN 0.1258 0.1142 0.1192 0.1176 0.1221 % DIFFERENCE -9.2 -5.2 -6.5 -2.9 S.D. 0.02109 0.01667 0.01521 0.01819 0.02475 S.E. 0.00609 0.00481 0.00439 0.00575 0.00715 N 12 12 12 10 12

OVARIES (G/100 G FINAL BODY WEIGHT) MEAN 0.037 0.035 0.037 0.035 0.037 S.D. 0.0046 0.0059 0.0046 0.0042 0.0071 S.E. 0.0013 0.0017 0.0013 0.0013 0.0020 N 12 12 12 10 12

OVARIES (G/100 G BRAIN) MEAN 6.345 5.825 6.196 5.915 6.191 S.D. 0.9988 0.6364 0.7677 0.9187 1.2287 S.E. 0.2883 0.1837 0.2216 0.2905 0.3547 N 12 12 12 10 12

PITUITARY (G) MEAN 0.0207 0.0190 0.0156** 0.0175* 0.0175* % DIFFERENCE -8.2 -24.6 -15.5 -15.5 S.D. 0.00310 0.00164 0.00257 0.00403 0.00177 S.E. 0.00089 0.00047 0.00074 0.00127 0.00051 N 12 12 12 10 12

----------------------------------------------------------------------------------------------------------------------------------- * = Significantly different from the control group at 0.05 using Dunnett's test ** = Significantly different from the control group at 0.01 using Dunnett's test**Page 140 of 1107**TABLE S45 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS

----------------------------------------------------------------------------------------------------------------------------------- FEMALES GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- PITUITARY (G/100 G FINAL BODY WEIGHT) MEAN 0.006 0.006 0.005** 0.005* 0.005 S.D. 0.0006 0.0006 0.0008 0.0010 0.0008 S.E. 0.0002 0.0002 0.0002 0.0003 0.0002 N 12 12 12 10 12

PITUITARY (G/100 G BRAIN) MEAN 1.044 0.971 0.811** 0.873* 0.891* S.D. 0.1420 0.0904 0.1476 0.1684 0.1088 S.E. 0.0410 0.0261 0.0426 0.0533 0.0314 N 12 12 12 10 12

SPLEEN (G) MEAN 0.70 0.72 0.83 0.87 0.74 % DIFFERENCE 2.9 18.6 24.3 5.7 S.D. 0.099 0.153 0.218 0.151 0.223 S.E. 0.028 0.044 0.063 0.048 0.064 N 12 12 12 10 12

SPLEEN (G/100 G FINAL BODY WEIGHT) MEAN 0.204 0.217 0.252* 0.259* 0.227 S.D. 0.0214 0.0345 0.0549 0.0462 0.0619 S.E. 0.0062 0.0100 0.0158 0.0146 0.0179 N 12 12 12 10 12

----------------------------------------------------------------------------------------------------------------------------------- * = Significantly different from the control group at 0.05 using Dunnett's test ** = Significantly different from the control group at 0.01 using Dunnett's test**Page 141 of 1107**TABLE S45 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS

----------------------------------------------------------------------------------------------------------------------------------- FEMALES GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- SPLEEN (G/100 G BRAIN) MEAN 35.238 36.526 43.048 43.611 37.527 S.D. 4.5542 7.0224 11.5808 7.2738 10.6020 S.E. 1.3147 2.0272 3.3431 2.3002 3.0605 N 12 12 12 10 12

----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group POFBSTv5.26 01/20/2014**Page 142 of 1107**TABLE S46 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF MICROSCOPIC FINDINGS

----- MALE -----

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5

----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 12 1 0 12 12

COAGULATING GL TOTAL NUMBER EXAMINED 12 NA NA 12 12 EXAMINED, UNREMARKABLE 12 NA NA 12 12

EPIDIDYMIS, LT TOTAL NUMBER EXAMINED 12 NA NA 12 12 EXAMINED, UNREMARKABLE 12 NA NA 12 12

EPIDIDYMIS, RT TOTAL NUMBER EXAMINED 12 NA NA 12 12 EXAMINED, UNREMARKABLE 12 NA NA 12 12

KIDNEYS TOTAL NUMBER EXAMINED 1 1 NA 1 2 EXAMINED, UNREMARKABLE 0 0 NA 0 0 -CONGESTION 1 0 NA 0 0 -DEGENERATION, TUBULAR 0 0 NA 0 1 -DILATATION, PELVIS 1 1 NA 0 1 -INDENTATION, CAPSULAR 0 0 NA 1 0

LN, MANDIBULAR TOTAL NUMBER EXAMINED NA NA NA NA 1 EXAMINED, UNREMARKABLE NA NA NA NA 0 -HYPERPLASIA, LYMPHOID NA NA NA NA 1

----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROL GROUP USING 2-TAILED FISHER'S EXACT TEST. NA = NOT APPLICABLE**Page 143 of 1107**TABLE S46 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF MICROSCOPIC FINDINGS

----- MALE -----

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5

----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 12 1 NA 12 12

LUNGS TOTAL NUMBER EXAMINED 12 NA NA 12 12 EXAMINED, UNREMARKABLE 4 NA NA 7 5 -ATELECTASIS 3 NA NA 2 3 -CONGESTION 0 NA NA 0 1 -HEMORRHAGE 0 NA NA 0 1 -INFLAMMATION, SUBACUTE 0 NA NA 1 0 -MINERALIZATION, VASCULAR 5 NA NA 2 4

PITUITARY TOTAL NUMBER EXAMINED 12 NA NA 12 12 EXAMINED, UNREMARKABLE 12 NA NA 12 12

PROSTATE TOTAL NUMBER EXAMINED 12 NA NA 12 12 EXAMINED, UNREMARKABLE 12 NA NA 10 11 -INFLAMMATION, SUBACUTE 0 NA NA 2 1

SEMINAL VESICLES TOTAL NUMBER EXAMINED 12 NA NA 12 12 EXAMINED, UNREMARKABLE 12 NA NA 12 12

----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROL GROUP USING 2-TAILED FISHER'S EXACT TEST. NA = NOT APPLICABLE**Page 144 of 1107**TABLE S46 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF MICROSCOPIC FINDINGS

----- MALE -----

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5

----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 12 1 NA 12 12

SPLEEN TOTAL NUMBER EXAMINED 12 NA NA 12 12 EXAMINED, UNREMARKABLE 12 NA NA 11 12 -FIBROSIS, CAPSULAR 0 NA NA 1 0 -INFLAMMATION, CHRONIC 0 NA NA 1 0

TESTIS, RT TOTAL NUMBER EXAMINED 12 NA NA 12 12 EXAMINED, UNREMARKABLE 12 NA NA 12 12

URETERS TOTAL NUMBER EXAMINED 1 1 NA NA NA EXAMINED, UNREMARKABLE 0 0 NA NA NA NOT PRESENT FOR EXAMINATION 0 0 NA NA 1 -DILATATION 1 1 NA NA NA

VAS DEFERENS TOTAL NUMBER EXAMINED 12 NA NA 12 12 EXAMINED, UNREMARKABLE 12 NA NA 12 12

----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROL GROUP USING 2-TAILED FISHER'S EXACT TEST. NA = NOT APPLICABLE PHSI2v4.37 02/18/2014**Page 145 of 1107**TABLE S47 (F0 FEMALES - FAILED TO DELIVER)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF MICROSCOPIC FINDINGS

----- FEMALE -----

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5

----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 0 0 0 1 0

CERVIX TOTAL NUMBER EXAMINED 0 NA NA 1 0 EXAMINED, UNREMARKABLE 0 NA NA 1 0

LUNGS TOTAL NUMBER EXAMINED 0 NA NA 1 0 EXAMINED, UNREMARKABLE 0 NA NA 1 0

MAMMARY GLAND TOTAL NUMBER EXAMINED 0 NA NA 1 0 EXAMINED, UNREMARKABLE 0 NA NA 1 0

OVARIES TOTAL NUMBER EXAMINED 0 NA NA 1 0 EXAMINED, UNREMARKABLE 0 NA NA 1 0

PITUITARY TOTAL NUMBER EXAMINED 0 NA NA 1 0 EXAMINED, UNREMARKABLE 0 NA NA 1 0

SPLEEN TOTAL NUMBER EXAMINED 0 NA NA 1 0 EXAMINED, UNREMARKABLE 0 NA NA 1 0

----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM NA = NOT APPLICABLE**Page 146 of 1107**TABLE S47 (F0 FEMALES - FAILED TO DELIVER)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF MICROSCOPIC FINDINGS

----- FEMALE -----

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5

----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 0 NA NA 1 0

UTERUS TOTAL NUMBER EXAMINED 0 NA NA 0 0 EXAMINED, UNREMARKABLE 0 NA NA 0 0 NOT PRESENT FOR EXAMINATION 0 NA NA 1 0

VAGINA TOTAL NUMBER EXAMINED 0 NA NA 1 0 EXAMINED, UNREMARKABLE 0 NA NA 1 0

----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM NA = NOT APPLICABLE PHSI2v4.37 02/18/2014**Page 147 of 1107**TABLE S48 (F0 FEMALES - TOTAL LITTER LOSS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF MICROSCOPIC FINDINGS

----- FEMALE -----

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5

----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 0 0 0 1 0

CERVIX TOTAL NUMBER EXAMINED 0 NA NA 1 0 EXAMINED, UNREMARKABLE 0 NA NA 1 0

LUNGS TOTAL NUMBER EXAMINED 0 NA NA 1 0 EXAMINED, UNREMARKABLE 0 NA NA 1 0

MAMMARY GLAND TOTAL NUMBER EXAMINED 0 NA NA 1 0 EXAMINED, UNREMARKABLE 0 NA NA 1 0

OVARIES TOTAL NUMBER EXAMINED 0 NA NA 1 0 EXAMINED, UNREMARKABLE 0 NA NA 1 0

PITUITARY TOTAL NUMBER EXAMINED 0 NA NA 1 0 EXAMINED, UNREMARKABLE 0 NA NA 0 0 -CYST, PARS DISTALIS 0 NA NA 1 0

SPLEEN TOTAL NUMBER EXAMINED 0 NA NA 1 0 EXAMINED, UNREMARKABLE 0 NA NA 1 0

----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM NA = NOT APPLICABLE**Page 148 of 1107**TABLE S48 (F0 FEMALES - TOTAL LITTER LOSS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF MICROSCOPIC FINDINGS

----- FEMALE -----

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5

----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 0 NA NA 1 0

SPLEEN - CONTINUED

UTERUS TOTAL NUMBER EXAMINED 0 NA NA 1 0 EXAMINED, UNREMARKABLE 0 NA NA 0 0 -EXUDATE, INFLAMMATORY 0 NA NA 1 0 -IMPLANTATION SITE 0 NA NA 1 0

VAGINA TOTAL NUMBER EXAMINED 0 NA NA 1 0 EXAMINED, UNREMARKABLE 0 NA NA 1 0

----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM NA = NOT APPLICABLE PHSI2v4.37 02/18/2014**Page 149 of 1107**TABLE S49 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF MICROSCOPIC FINDINGS

----- FEMALE -----

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5

----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 12 1 1 10 12

CERVIX TOTAL NUMBER EXAMINED 12 NA NA 10 12 EXAMINED, UNREMARKABLE 12 NA NA 10 12

KIDNEYS TOTAL NUMBER EXAMINED NA 1 NA NA NA EXAMINED, UNREMARKABLE NA 1 NA NA NA

LUNGS TOTAL NUMBER EXAMINED 12 NA NA 10 12 EXAMINED, UNREMARKABLE 7 NA NA 10 7 -ATELECTASIS 2 NA NA 0 2 -MINERALIZATION, VASCULAR 3 NA NA 0 3

MAMMARY GLAND TOTAL NUMBER EXAMINED 12 NA NA 10 12 EXAMINED, UNREMARKABLE 12 NA NA 10 11 -INFLAMMATION, SUPPURATIVE 0 NA NA 0 1

OVARIES TOTAL NUMBER EXAMINED 12 NA NA 10 12 EXAMINED, UNREMARKABLE 11 NA NA 9 12 -CYST, FOLLICULAR 1 NA NA 0 0 -HEMORRHAGE 0 NA NA 1 0

----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROL GROUP USING 2-TAILED FISHER'S EXACT TEST. NA = NOT APPLICABLE**Page 150 of 1107**TABLE S49 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF MICROSCOPIC FINDINGS

----- FEMALE -----

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5

----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 12 1 1 10 12

PITUITARY TOTAL NUMBER EXAMINED 12 NA NA 10 12 EXAMINED, UNREMARKABLE 12 NA NA 10 12

SPLEEN TOTAL NUMBER EXAMINED 12 NA 1 10 12 EXAMINED, UNREMARKABLE 12 NA 0 9 11 -FIBROSIS, CAPSULAR 0 NA 1 1 0 -HEMATOPOIESIS, EXTRAMEDULLARY, INCREASED 0 NA 0 0 1

UTERUS TOTAL NUMBER EXAMINED 12 NA NA 10 12 EXAMINED, UNREMARKABLE 0 NA NA 1 0 -IMPLANTATION SITE 12 NA NA 9 12

VAGINA TOTAL NUMBER EXAMINED 12 NA NA 10 12 EXAMINED, UNREMARKABLE 12 NA NA 10 12

----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROL GROUP USING 2-TAILED FISHER'S EXACT TEST. NA = NOT APPLICABLE PHSI2v4.37 02/18/2014**Page 151 of 1107**TABLE S50 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF OVARIAN PRIMORDIAL FOLLICLE COUNTS

FEMALES

GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- PRIMORDIAL FOLLICLES MEAN 49.3 NA NA 43.1 68.0 S.D. 21.93 17.31 51.94 S.E. 6.33 5.00 14.99 N 12 12 12

----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group MANUALv1.0 01/21/2014 R:01/21/2014**Page 152 of 1107**TABLE S51 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF PND 0 LITTER DATA

GROUP : 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NUMBER BORN MEAN 14.3 13.8 13.7 13.3 13.9 S.D. 1.78 2.12 2.96 2.10 1.24 S.E. 0.51 0.61 0.86 0.63 0.36 N 12 12 12 11 12

SEX AT BIRTH (% MALES PER LITTER) MEAN 57.3 47.7 48.9 54.6 52.6 S.D. 12.61 11.09 11.29 14.17 14.79 S.E. 3.64 3.20 3.26 4.27 4.27 N 12 12 12 11 12

LIVE LITTER SIZE (PND 0) MEAN 13.9 13.6 13.0 12.7 13.5 S.D. 1.98 2.39 2.98 1.74 1.51 S.E. 0.57 0.69 0.86 0.52 0.44 N 12 12 12 11 12

----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM SEX COMPARED USING DUNN'S TEST, NUMBER BORN, AND LIVE LITTER SIZE COMPARED USING DUNNETT'S MODIFIED STATISTICS USED. * INDICATES PARAMETRIC ANALYSIS AND + INDICATES NON-PARAMETRIC ANALYSIS. None significantly different from control group PPVIASv5.12 02/18/2014 R:02/18/2014**Page 153 of 1107**TABLE S52 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF POSTNATAL SURVIVAL [% PER LITTER]

GROUP : 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

PND 0 (RELATIVE TO NUMBER BORN) MEAN 96.5 98.0 95.2 95.4 97.0 S.D. 4.76 5.11 5.80 6.79 5.75 S.E. 1.37 1.48 1.67 2.05 1.66 N 12 12 12 11 12

PND 0 TO PND 1 MEAN 99.2 98.1 96.1 91.7 99.4 S.D. 2.89 3.44 6.10 6.70 2.22 S.E. 0.83 0.99 1.76 2.02 0.64 N 12 12 12 11 12

PND 1 TO PND 4 MEAN 97.1 95.9 91.7 76.5 99.3 S.D. 4.92 7.52 12.64 31.21 2.41 S.E. 1.42 2.17 3.65 9.41 0.69 N 12 12 12 11 12

BIRTH TO PND 4 MEAN 92.8 92.1 84.1 67.9 95.7 S.D. 6.18 8.38 15.11 29.19 6.65 S.E. 1.78 2.42 4.36 8.80 1.92 N 12 12 12 11 12

----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM STATISTICS PERFORMED USING DUNN'S TEST MODIFIED STATISTICS USED. None significantly different from control group PPVIASv5.12 02/18/2014 R:02/18/2014**Page 154 of 1107**TABLE S53 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF PUPS

CATEGORY FINDING GROUP: 1 2 3 4 5

----------------------------------------------------------------------------------------------------------------------------------- NORMAL NO SIGNIFICANT CLINICAL OBSERVATIONS 323/164 308/158 286/148 213/121 319/161 LITTERS: 12 12 12 11 12

DISPOSITION FOUND DEAD; PARTIALLY CANNIBALIZED 0/ 0 0/ 0 0/ 0 0/ 0 2/ 2 LITTERS: 0 0 0 0 2

FOUND DEAD 11/ 11 11/ 11 16/ 16 33/ 33 5/ 5 LITTERS: 8 6 9 10 4

SCHEDULED EUTHANASIA 160/160 153/153 141/141 95/ 95 160/160 LITTERS: 12 12 12 10 12

MISSING 1/ 1 2/ 2 7/ 7 18/ 18 0/ 0 LITTERS: 1 2 5 5 0

BODY/INTEGUMENT SMALL STATURE 1/ 1 6/ 3 3/ 2 2/ 2 1/ 1 LITTERS: 1 3 2 2 1

CYANOTIC 0/ 0 0/ 0 1/ 1 5/ 5 0/ 0 LITTERS: 0 0 1 4 0

SUBCUTANEOUS HEMORRHAGE DORSAL HEAD 0/ 0 0/ 0 0/ 0 2/ 2 0/ 0 LITTERS: 0 0 0 2 0

SUBCUTANEOUS HEMORRHAGE FACIAL AREA 0/ 0 0/ 0 2/ 1 5/ 5 1/ 1 LITTERS: 0 0 1 4 1

----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM**Page 155 of 1107**TABLE S53 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF PUPS

CATEGORY FINDING GROUP: 1 2 3 4 5

----------------------------------------------------------------------------------------------------------------------------------- BODY PALE 2/ 2 0/ 0 1/ 1 0/ 0 0/ 0 LITTERS: 2 0 1 0 0

BODY COOL 1/ 1 1/ 1 0/ 0 0/ 0 0/ 0 LITTERS: 1 1 0 0 0

FILAMENTOUS TAIL 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0 LITTERS: 0 0 0 1 0

TAIL MISSING 0/ 0 0/ 0 0/ 0 4/ 2 0/ 0 LITTERS: 0 0 0 2 0

CARDIO-PULMONARY GASPING 1/ 1 1/ 1 0/ 0 1/ 1 0/ 0 LITTERS: 1 1 0 1 0

----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM PPOCRDv1.05 01/07/2014 R:01/17/2014**Page 156 of 1107**TABLE S54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF OFFSPRING WEIGHTS [G]

(LITTER AS EXPERIMENTAL UNIT) GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- PND 1 MALES MEAN 6.8 7.9** 7.6** 7.3 7.8** % DIFFERENCE 16.2 11.8 7.4 14.7 S.D. 0.87 0.60 0.33 0.58 0.59 S.E. 0.25 0.17 0.10 0.18 0.17 N 12 12 12 11 12

FEMALES MEAN 6.6 7.3 7.2 6.9 7.2 % DIFFERENCE 10.6 9.1 4.5 9.1 S.D. 0.77 0.74 0.40 0.73 0.60 S.E. 0.22 0.22 0.11 0.22 0.17 N 12 12 12 11 12

PND 4 MALES MEAN 9.6 10.2 9.7 9.7 10.2 % DIFFERENCE 6.3 1.0 1.0 6.3 S.D. 1.60 0.87 0.88 1.17 0.88 S.E. 0.46 0.25 0.25 0.37 0.26 N 12 12 12 10 12

FEMALES MEAN 9.1 9.5 9.4 9.3 9.5 % DIFFERENCE 4.4 3.3 2.2 4.4 S.D. 1.48 0.88 0.75 1.29 0.62 S.E. 0.43 0.25 0.22 0.41 0.18 N 12 12 12 10 12

----------------------------------------------------------------------------------------------------------------------------------- PND = POSTNATAL DAY ** = Significantly different from the control group at 0.01 using Dunnett's test PPWSUSNv5.17 01/07/2014 R:01/17/2014**Page 157 of 1107**TABLE S55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF OFFSPRING WEIGHT CHANGES [G]

(LITTER AS EXPERIMENTAL UNIT) GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- PND 1 TO 4 MALES MEAN 2.7 2.3 2.0 2.3 2.5 S.D. 0.88 0.53 0.68 0.85 0.56 S.E. 0.25 0.15 0.20 0.27 0.16 N 12 12 12 10 12

FEMALES MEAN 2.5 2.2 2.1 2.3 2.3 S.D. 0.80 0.49 0.58 0.62 0.39 S.E. 0.23 0.14 0.17 0.20 0.11 N 12 12 12 10 12

----------------------------------------------------------------------------------------------------------------------------------- PND = POSTNATAL DAY None significantly different from control group PPWSUSNv5.17 01/07/2014 R:01/17/2014**Page 158 of 1107**TABLE S56 (F1 - UNSCHEDULED DEATHS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF PUP NECROPSY FINDINGS

FOUND DEAD OR EUTHANIZED MORIBUND OR IN EXTREMIS

----------------------------------------------------------------------------------------------------------------------------------- P U P S L I T T E R S DOSE GROUP: 1 2 3 4 5 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NUMBER EXAMINED VISCERALLY 11 11 16 33 7 8 6 9 10 4

STOMACH MILK NOT PRESENT 3 3 8 10 3 3 2 6 6 3 MILK PRESENT 1 0 0 2 0 1 0 0 2 0

MALFORMATION INTERVENTRICULAR SEPTAL DEFECT 0 0 1 5 0 0 0 1 2 0 VERTEBRAL AGENESIS 0 0 0 1 0 0 0 0 1 0 ANAL ATRESIA 0 0 0 1 0 0 0 0 1 0 KIDNEY(S)- FUSED 0 0 0 1 0 0 0 0 1 0 CONJOINED TWIN 1 0 0 0 0 1 0 0 0 0

VARIATION MAJOR BLOOD VESSEL VARIATION 0 0 0 1 0 0 0 0 1 0 THORACIC CAVITY- CONTENTS, DARK RED 0 0 0 1 0 0 0 0 1 0

----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- PPNSIv4.06 02/24/2014**Page 159 of 1107**

## WI L

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene

American Pacific Corporation



# APPENDIX **A**

Study Protocol and Deviations

**Page 160 of 1107**

## WI L

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene

American Pac ific Corporation



# D **EVIATIONS F**  **ROM THE** 

# P **ROTOCOL**



## This study

w as conducted in accordance with the protocol and protocol amendments,
except for the following.



# • **Protocol Section**  **5.7** states that individual cage cards will be affixed to each cage and will display

t he animal number

, group number, study n umber, dosage level, and

sex of the animal. O n 25 November 2013, animals were sent to necropsy w ith pretest cage cards affixed to the animals’ cages. T hese labels did not include the group number or dosage level.

**Impact Assessment:**  The slight deviation did not impact the study

, as the animals were still identifiable b y necrops y staff and were necropsied per protocol.



# • **Protocol Section 7.4.3** states that the test and control items will be administered as a daily 6

- hour whole

- body

inh alation exposure for Groups 1, 2, 3, and 4. The test item will be administered as a dail y 5

- minute exposure for Group 5. O n 09 November 2013, no end of exposure time was recorded for Chamber 5 (filtered air).

**Impact Assessment:**  The lack of documentation of the end of exposure occurred in the filtered air chamber, and therefore had no impact on the quality or integrit y of the study

.



# • **Protocol Section 7.4.3** states that the test and control items will be administered as a daily 6

- hour whole

- body

i nhalation e xposure fo r Groups 1, 2, 3, and 4. O n 10 November 2013, the exposure for Groups 2, 3, and 4 was ex tended. I t was not documented that Chamber 1 (filtered air) was extended nor what time Chamber 1

was opened. S ince generation was terminated at 1608 hours and the first animal from Chamber 1 was not unloaded until 1613 hours

, it is believed that Chamber 1 was opened at 1608 hours, and therefore received an exposure of 6 hours 30 minutes.

**Impact Assessment:**  The lack of documentation of the extended exposure occurred in the filtered air chamber, and therefore had no impact on the quality or in tegrit y of the study

.

**Page 161 of 1107**

## WI L

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene

American Pac ific Corporation



# • **Protocol Section**  **7.4.4** states that the dail y average relative humidity f or each
exposure chamber will be between 30% to 70%. O n 18, 23

, and 24 October 2013

, the mean relative humidity f or Chamber 5 (filtered air) was 28%, 29%

, and 23%, respectivel y. O n 02 November, 2013, the mean relative humidity f or Chamber 5 (10,000 ppm) was 76%. On 23 November 2013, the mean relative humidity f or Chamber 4 (175 ppm) was 29 .1 %.

**Impact Assessment:**  The slight deviation in humidity o n these day s had no impact on the study

a s there were no apparent effects on the animals based on post

- exposure observations.



# • **Protocol Section**  **7.4.4** states that the chambers will be operated under dy namic conditions, at a slight negative p ressure (ca. 0.5 in. of water) with at least 12 to 15 air changes per hour. On 20 and 22 October 2013, Chamber 5 (10,000 ppm) was operated with more than 15 air changes per hour. On 26 October, 07 November, and 08 November 2013, Chamber 5 (10,000 ppm) was operated with less than 12 air changes per hour.

**Impact Assessment:**  These deviation s had no impact because animals were onl y in the 10,000 ppm exposure chamber for approximately 9 m inutes an d the variation in air changes per hour had no apparent effect on the animals based on post

- exposure observations.



# • **Protocol Section**  **7.4.4** states that the chambers will be operated under dy namic conditions, at a slight negative p ressure (ca. 0.5 in. of wate r) with at least 12 to 15 air changes per hour. On 07, 08, 24, 25

, 26, and 27 October 2013 and 12 November 2013 , Chamber 5 (filtered air) was operated with less than 12 air changes per hour.

**Impact Assessment:**  These deviation s had no impact on the stud y as the chamber was filtered air onl y.



# • **Protocol Section**  **7.4.4** states that the chambers will be operated under dy namic conditions, at a slight negative p ressure (ca. 0.5 in. of water) with at least 12 to 15 air changes per hour. On 24 October 2013, Chambe r 1 (filtered air) and Chamber 2 (50 ppm) were not operated at a slight negative pressure during the second round of sampling. O n 27 October 2013, Chamber 1 (filtered air) and Chamber 3 (100 ppm)

were not operated at a slight negative pressure during fift h and first round of sampling, respectivel y. On 05 November 2013, Chamber 1 (filtered air) was not operated at a slight negative pressure during the sixth sampling round. On 20 November 2013, Chamber 3 (100 ppm) and Chamber 4 (175 ppm) were not operated at a slight negative pressure during the first and second sampling rounds.

**Impact Assessment:**  This deviation had no impact on the study a s the chamber air was sampled throughout exposure and no test substance was detected.

**Page 162 of 1107**

## WI L

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene

American Pac ific Corporation



# • **Protocol Section**  **7.6** does not st ate that homogeneity o f exposure atmospheres will be performed. H owever, homogeneit y was performed on Chamber 2 (50 ppm), Chamber 3 (100 ppm), Chamber 4 (175 ppm), and Chamber 5 (10,000 ppm).

**Impact Assessment:**  The addition of homogeneity analy sis ensure s appropriate
exposure to the test substance regardless of chamber location

, and therefore did not impact the study

.



# • **Protocol Section**  **7.6.2** states that actual concentrations of the test substance in the
exposure atmospheres will be determined at least at h ourly i ntervals for each chamber. O n 14

- 21 October, 23

- 26 October, 29

- 30 October, 01 November, 10 November, and 12 November 2013, the Chamber 5 (filtered air) concentrations were not determined at hourly intervals.

**Impact Assessment:**  The filtered air c oncentrations that were taken on these day s

were 0 ppm; therefore, this deviation had no impact on the quality o r integrit y of the study

.



# • **Protocol Section**  **7.6.2** states that actual concentrations of the test substance in the
exposure atmospheres will be det ermined at least at hourly i ntervals for each chamber. O n 17 October 2013, Chamber 3 (100 ppm) and Chamber 4 (175 ppm) concentrations were not determined at hourl y intervals. O n 04 and 07 November 2013, concentrations for Chamber 1 (filtered air), Chambe r 2 (50 ppm), Chamber 3 (100 ppm), and Chamber 4 (175 ppm) were not determined at hourly i ntervals. On 28 November 2013, the concentration for Chamber 4 (175 ppm) was not determined at hourly intervals.

**Impact Assessment**  **:** This deviation had no impact o n the study b ecause sufficient sampling was performed to determine average concentrations for these day s and the daily means were within 10% of the target concentration.



# • **Protocol Section**  **7.6.2** states that all chamber concentration data will be collected

au tomatically

t hrough the use of the Inhalation Exposure Data Collection Sy stem (WI NH) and a personal computer. C hamber 5 (filtered air and 10,000 ppm) concentration data was manually collected throughout the course of the study

. **Impact Assessment**  **:** This de viation had no impact on the study b ecause the chamber concentrations were collected.

**Page 163 of 1107**

## WI L

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene

American Pac ific Corporation



# • **Protocol Section**  **7.6.3** states that the control and high

- concentration chambers will be monitored for aerosol formation during method development. H owever, only t he

co ntrol (filtered air) and Chamber 4 (175 ppm) were monitored for aerosol formation during method development.

**Impact Assessment**  **:** Chamber 4 (175 ppm) was the highest exposure concentration for the full 6

- hour dail y test substance exposure; therefore, aeroso l formation was monitored as appropriate for this study design and this deviation had no impact on the qual ity

and integrity

of the study

.



# • **Protocol Section 7.7** states that daily vaginal lavages will be performed to determine the stage of estrus beginning 1 0 day s prior to treatment and continuing until evidence of mating is observed. T he cy tology s lide for female no. 91672 in the control group

was unable to be anal yzed at the time of the determination of stage of estrous because the slide was inadvertentl y discarded. T he slide was broken when it was discarded and, therefore, determination of estrous stage was not possible.

**Impact Assessment**  **:** The loss of a single data point of estrous cy cle data for a control animal had no impact on the study

, as there was sufficient cy cle data for this female.



# • **Protocol Section 7.7** states that daily vaginal lavages will be performed to determine the stage of estrus beginning 10 day s prior to treatment and continuing until evidence of mating is observed. Lavaging will contin ue for those females with no evidence of mating until termination of the mating period. Upon review of raw data, it was noted that female no. 91623 in the 175 ppm group had a slide present for determination of stage of estrous 1 day

a fter the scheduled co mpletion date of determination of stage of estrous.

**Impact Assessment**  **:** This deviation has no impact on the study

, as the female was determined to be nongravid as appropriate.



# • **Protocol Section**  **7.11.1** states that each animal w ill be observed approximately 1 hour following each exposure for findings that are potentiall y related to treatment

or that might change before the next scheduled observation. B ased on the unscheduled observations noted on the first day of exposure for Group 5 (10,000 ppm), post

- expo sure observations were also conducted at approximately 15 mi nutes and approximately 1 hour following the 5

- minute test substance exposure period for Group 5 (10,000 ppm) for the remainder of the exposure period.
**Impact Assessment :**  The addition of observ ation time points to allow for capture of adverse clinical observations for Group 5 (10,000 ppm) had no impact on the quality or integrity

of the study

.

**Page 164 of 1107**

## WI L

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene

American Pac ific Corporation



# • **Protocol Section**  **7.11.1** states that all animals will be observed on the day o f
necrops y and findings wi ll be recorded. However

, 6 males and 4 females in the control group, 6 males and 3 females in the 50 ppm group, 6 males and 3 f emales in the 100 ppm group, 6 males and 1 female in the 175 ppm group, and 6 males and 5 females in the 10,000 ppm group did no t receive a clinical observation prior to being sent to necrops y.
**Impact Assessment**  **:** The lack of single observation for each animal did not affect data interpretation for this study

.



# • **Protocol Section**  **7.11.1** states that a detailed phy sical examination would be conducted weekl y. F emale no. 91637 in the control group received a detailed phy sical examination on the 18 and 19 November 2013

. **Impact Assessment**  **:** Additional observations for a single animal had no impact on the quality

or integrity

of the study

.



# • **Protocol Section**  **8.3** states that sections of 2

- 4 microns of the testis (transverse) will be stained in PAS and hematox yl in in addition to routine hematoxy lin and eosin staining. At the time of trimming, it was discovered that 5 males from the 10,00 0 ppm group (nos. 91600, 91557, 91554, 91571, 91575, and 91558) had incorrectly

t rimmed testes. T estes for each animal were trimmed longitudinally instead of transverse. T he wet tissue remnants for each animal were pieced together so that a transverse se ction could be submitted for each animal.

**Impact Assessment**  **:** This deviation had no impact on the study a s the longitudinal sections were corrected and a transverse view was examined.

**Page 165 of 1107**

## PROTOCOL AMENDMENT 2

Study Number: WIL

- 65501

Sponsor: American Pacific Corporation

Title of Study :

An Inhalation Reproduction/Developmental Toxicity Screening Study of 2

- Bromo

- 3,3,3

- Triflouropropene in Rats

Protocol Modifications :

1) 8.3 Microscopic Examination :

The first sentence of this section is changed to the following:

Microscopic examination will be performed on the following tissues from all F 0 

## parental animals from the control and 175 ppm and 10,000 ppm dose groups and from all parental animals dying spontaneously or euthanized in extremis

. All g ross lesions will be examined microscopically, irrespective of group.

Reasons for Protocol Modification :

1) Addition of 175 ppm exposure level for histopathological examination. The 175 ppm group was the high dose for the full 6 hour exposure duration.

**Page 166 of 1107**

## Page 

## 2 of' 

## 2



## Sponsor's approval was obtained 

## via cmail on 02 

## January 2014.



## WTL Research



## Study Director

American Pacific Corpora tiot



## Sponsor Representative



## Page 167 of 1107

## PROTOCOL AMENDMENT 1

Study Number: WIL

- 65501

Sponsor: American Pacific Corporation

Title of Study :

An Inhalation Reproduction/Developmental Toxicity Screening Study of 2

- Bromo

- 3,3,3

- Triflouropropene in Rats

Protocol Modifications :

1) 2.4 Contributing Scientist, Study Pathologist:

The following personnel added:

Catherine A. Picut , VM D , DACVP , DABT Senior Pathologist WIL Research 310 Millstone Dr. Hillsborough, NC 27278 Tel: (919) 245

- 3114 x 106 Fax: (919) 245

- 3115 Email: catherine.picut @wilresearch.com

2 ) 7.11.2.2 Females:

The second paragraph is removed from this section as noted below:

Recorded individually on a weekly basis, beginning on the first day of exposure until evidence of copulation is observed or until euthanasia (for females without evidence of mating) 

## . Following evidence of copulation, body weights will be recorded on gestat ion days 0, 4, 7, 11, 14, 17 and 20 and lactation days 1 and 4. For females with evidence of mating that do not deliver, body weights will have been recorded on the presumed gestation days indicated above and then on the day of scheduled euthanasia (post

- m ating day 25).

If a female is determined to have completed parturition at the morning parturition examinations, a lactation day 0 weight will be recorded for the female, and the weight

**Page 168 of 1107**

## WIL

- 65501 Page 2 of 3 Protocol Amendment 1

will be used for calculation of dose volume. The lactation day 0 weights will not be summarized or analyzed statistically but will be included on the individual animal data tables.

3 ) 7.12.1.2 Female Which Fail to Deliver :

The following is added to this section:

If the females are determined to be pregnant by macrosc opic examination or ammonium sulfide staining, the number of implantation sites and corpora lutea will be recorded. Any products of conception will be discarded without further examination.

4) 8.1 Macroscopic Examination:

The mammary glands will be coll ected from the females only. For the liver, sections of 2 lobes will be retained.

5 ) 10.1 Parental In

- life Data :

The first sentence is changed to the following:

Continuous data variables [mean b ody weights, body weight gains, food consumption and water consumption at each interval], pre

- coital intervals, mean estrous cycle length, gestation length, former implantation sites, corpora lutea and unaccounted

- for sites will be subjected to a parametric one

- way analysis of variance (ANOVA) (Snedecor and Cochran, 1980) to determine intergroup difference.

Reasons for Protocol Modification :

1) Addition of Study Pathologist.

2) Removal of typographical error; not required as exposure is via inhalation.

3) Addition of examination of the uterus in the event of pre gnancy for females which fail to deliver.

4) Clarification that mammary glands are to be collected from females only.

5) Addition of statistical analysis on the water consumption data being collected.

**Page 169 of 1107**

## Page 3 of 3 

## WIL-65503 Protocol Amendment 

## I

sponsor's approval was 

## obtained via 

## email 

## an 21 October 

## 2013.



## WL Research



# 0cT 7Ct3

mye 

## L. 

## Edwards, BS Date 

## Study Director

American 

## Pacific Corpora 

## tion A



## V 

# ~radford Colton Date Sponsor Representative



## Page 170 of 1107WIL

- 65501 Page 1 of 29 25 September 2013



## PROTOCOL

An Inhalation Reproduction/Developmental Toxicity Screening Study o f 2

- Bromo

- 3,3,3

- Trifluoropropene i n Rats

[ OECD Guideline 421 ]

WIL Study Number: WIL

- 65501

Submitted To:

American Pacific Corporation 3883 Howard Hughes Parkway, Suite 700 Las Vegas, NV 89169

WIL Research 1407 George Road Ashland, OH 44805

- 8946

**Page 171 of 1107**WIL 65501 Page 2 of 29 25 September 2013



## 1 OBJECTIVE:

To provide preliminary information on the potential adverse effects of the test item on male and female reproduction within the scope of a screening study. This will encompass gonadal function, mating behavior, conception, parturition and lactation of the F 0 

## generation and the development of offspring from conception through day 4 of
pos tnatal life.

This study will be conducted in accordance with the Organisation for Economic Cooperation and Development (OECD) Guideline for Testing of Chemicals, Guideline 421, Reproduction/Development Toxicity Screening Test, July 27, 1995.

This study wi ll be conducted in compliance with the EPA/TSCA (40 CFR Part 792 ) Good Laboratory Practice Standards and the OECD [C(97) 186/Final] Principles of Good Laboratory Practice

.

2 PERSONNEL INVOLVED I N THE STUDY:

2.1 Sponsor Representative:

Bradford Colton American Pacific Corporation 3883 Howard Hughes Parkway, Suite 700 Las Vegas, NV USA 89169 Tel: (702) 699

- 4131 Fax: (702) 735

- 4876 Email: bcolton @apfc.com

2.2 Sponsor Monitor :
Stephanie Skaggs Universal Technical Services, Inc. Tel: (505) 856

- 1847 Cell: 505) 681

- 5585 Fax: (505) 212

- 0491 Email:srskaggs@msn.com

2.3 WIL Study Director:

Tammye L. Edwards, BS Senior Toxicologist, Developmental and Reproductive Toxicology Tel: (419) 289

- 8700 Fax: (419) 289

- 3650 Email: tammye.edwards@wilresearch.com

**Page 172 of 1107**WIL 65501 Page 3 of 29 25 September 2013



## 2.4 Contributing Scientist, Study Pathologist:

To be added by amendment

2.5 Contributing Scientist, Ovarian Primordial Follicle Evaluation:

Catherine A. Picut, VMD, DACVP, DABT Senior Pathologist WIL Research 310 Millstone Dr. Hillsborough, NC 27278 Tel: (919) 245

- 3114 x106 Fax: (919) 245

- 3115 Email: catherine.picut@wilresearch.com

2.6 Principal Investigator (Ovarian Histology):

Sirena Hudgins, HT (ASCP) Supervisor , Histology WIL Research 310 Millstone Dr. Hillsborough, NC 27278 Tel: (919) 245

- 3114 x114 Fax: (919) 245

- 3115 Email: s irena. h u dgins@wilresearch.com

2.7 Test Site Quality Assurance:

For histology conducted at WIL Research at Hillsborough:

Janice Jackson

- Freeman Compliance Specialist, Quality Assurance WIL Research 310 Millstone Dr. Hillsborough, NC 27278 Tel: (919) 245

- 3114 x119 Fax: (919) 245

- 3115 Email: janice. freeman@wilresearch.com

**Page 173 of 1107**WIL 65501 Page 4 of 29 25 September 2013



## 2.8 WIL Departmental Responsibilities:

Prägati Sawhney

- Coder, PhD, DABT Senior Toxicologist, Developmental and

Reproductive Toxicology Emergency Contact Tel: (419) 289

- 8700 Fax: (419) 289

- 3650 Email: Pragati.Sawhney.Coder@wilresearch.com

Donald G. Stump, PhD, DABT Vice Pre sident, Nonclinical Safety Science, US

Eddie D. Sloter, PhD Associate Director, Developmental

and Reproductive Toxicology

Erica L. Lashley, BS, LAT Senior Operations Manage r, Animal Operations

Gwendalyn M. Maginnis, DVM Clinical Veterinarian

Carol A. Kopp, BS, LAT Manager, Developmental Toxicology Laboratory

Andrew M. Vick, PhD Senior Director, Analytical Services

George A. Parker, DVM, PhD, DACVP, DABT Vice President, Global Pathology

Heather L. Johnson, BS RQAP

- GLP Assistant Director, Quality and Regulatory Compliance

Robert A. Wally, BS Operations Manager, Reporting &

Technical Support Services

**Page 174 of 1107**WIL 65501 Page 5 of 29 25 September 2013



## 3 STUDY SCHEDULE:

Proposed Experimental Starting (Animal Receipt) Date: 26 September 2013

Proposed Experimental Start (First Day of Exposure ) Date: 14 October 2013

Proposed Completion of In- life Phase Date: 06 December 2013

Proposed Experimental Completion/ Termination (Last Pathological Examination) Date: To be added by Amendment

Proposed Unaudited Draft Report: 29 January 2014

Proposed Audited Report Date: 28 February 2014

4 TEST ITEM DATA:

4.1 Test Item Shipment:

Test item and applicable documentation, including a Certificate of Analysis, will be shipped under Sponsor’s responsibility to:

Tammye Edwards (WIL -65501) Attn: Formulations Laboratory WIL Research 1407 George Road Ashland, Ohio 44805-8946 Tel: (419) 289-8700 Fax: (419) 289-3650 Email: tammye.edwards@wilresearch.com

4.2 Identification:

2- Bromo -3,3,3-Trifluoropropene, CAS:1514-82-5

This material contains stabilizer additives:

**Page 175 of 1107**WIL 65501 Page 6 of 29 25 September 2013



## 4.3 Lot Number:

WNCC

- BTP111128

4.4 Expiration/Retest Date:

10/1/2014

4.5 Purity:

≥ 99.6%

4.6 Storage Conditions:

Store room temperature or cooler. Store in closed container which is free of air and moisture.

4.7 Stability:

The test item is considered to be stable under the st orage conditions provided by the Sponsor. This material is susceptible to degradation when exposed to air and moisture. All connections, hoses, and headspace of cylinders material is transferred into should be under vacuum or purged with nitrogen or argo n.

4.8 Reserve Samples:

Reserve samples of the test item will be taken in accordance with WIL Standard Operating Procedures and stored in the WIL Research Archives indefinitely, unless otherwise specified.

4.9 Personnel Safety Data:

To be provided by the Sponsor. It is the responsibility of the Sponsor to notify the testing facility of any special handling requirements for the test item. A Material Safety Data Sheet (MSDS) should accompany the test item upon arrival at the laboratory.

4.10 Test Item Disposition:

With the exception of the reserve sample for each batch of test item, all neat test item remaining at study completion will be returned to the Sponsor. The test item will be shipped under ambient conditions to the following:

**Page 176 of 1107**WIL 65501 Page 7 of 29 25 September 2013 

## Clay Heyborne Halotron Division A merican Pacific Corporation 10622 West 6400 North Cedar City, Utah 84721

- 9016 Tel: (435) 865

- 5000 Email: cheyborne@apfc.com

5 TEST SYSTEM:

5.1 Species:

Rat

5.2 Strain:

Sprague Dawley Crl:CD(SD)

5.3 Source:

Charles River Laboratories, Inc. (Facility to be documented in the study records).

5.4 Number on Study:

60 males and 60 females (minimum of 66 males and 66 females purchased; males and females will be ordered from separate barrier rooms to ensure avoidance of sibling mating). Animals not assigned to study will be transferred to the stock animal colony or will be euthanized by carbon dioxide inhalation and t he carcasses discarded.

The number of animals is based on the OECD Gui deline for Testing of Chemicals: Guideline 42 1

, Reproduction/Development Toxicity Screening Test, July 27, 1995 , which recommends evaluation of at least 8 pregnant females per
group

. Gi ven the possibility of non

- gravid animals, unexpected deaths, total litter losses, or treatment

- related moribundity and/or mortality, this is an appropriate number of animals to obtain a sample size of 8 at termination

.

5.5 Body Weight Range:

At randomization: Males 250

- 5 00 g Females 170

- 280 g

5.6 Approximate Age:

Males: 71

- 85 days at the start of dosing

**Page 177 of 1107**WIL 65501 Page 8 of 2 9 25 September 2013



## Females: 61

- 75 days at the start of estrous cycle determination All rats will be a minimum of 85 days of age at the start of the breeding period.

5.7 Identific ation System:

The F 0 

## animals will be uniquely identified by a Monel ® 

## metal ear tag displaying the animal number. Individual cage cards will be affixed to each cage and will display the animal number, group number, study number, dosage level, and sex of the animal.

5.8 Justification for Selection:

This species and strain of ani mal is recognized as appropriate for reproduction studies. WIL Research has reproductive historical control data in the Crl:CD(SD) rat. This animal model has been proven to be susceptible to the effects of reproductive toxicants.

6 SPECIFIC MAINTENANCE SCH EDULE:

6.1 Animal Housing:

All males will be individually housed in clean suspended wire

- mesh cages in an environmentally controlled room during acclimation and continuing until euthanasia. All females will be individually housed in clean suspended wire

- mesh cages in an environmentally controlled room during acclimation and continuing until mating. The cages will be elevated above cage

- board or other suitable material, which will be changed at least three times each week. During cohabitation, the females wil l be paired (1:1) with a male from the same treatment group in a suspended wire

- mesh cage (home cage of the male). Following successful mating, the females will be housed individually in a plastic cage containing ground corncob nesting material (Bed

- O'Cob s ® 

## ) and will remain in these cages until euthanasia on lactation day 4. Nylabone ® 

## (or a similar enrichment device) will be provided to each animal for environmental enrichment and to aid in maintaining the animal's oral health, beginning during acclimatio n and continuing throughout the course of the study. The cages will be subjected to routine cleaning at a frequency consistent with maintaining good animal health and WIL Standard Operating Procedures. The facilities at WIL Research are accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC International).

6.2 Environmental Conditions:

Controls will be set to maintain temperature at 71 ± 5°F (22 ± 3°C) and relative humidity at 50 ± 20%. Temperature and relative humidity will be monitored continuously. Data for these two parameters will be scheduled for automatic

**Page 178 of 1107**WIL 65501 Page 9 of 29 25 September 2013 

## collection on an hourly basis. Fluorescent lighting controlled by light timers will provide illumination for a 12

- hour light/dark photoperiod. The ventilation rate will be set at a minimum of 10 room air changes per hour, 100% fresh air.

6.3 Drinking Water:

Reverse osmosis

- purified water will be available ad libitu m except during test item exposure from water bottles attached the cages. Water consu mption will be recorded during the study; therefore, the cages will not be attached the automatic watering system. The municipal water supplying the laboratory is analyzed according to WIL Standard Operating Procedures on a routine basis to ensure that con taminants are not present in concentrations that would be expected to affect the outcome of the study.

Water restriction during the exposure period is necessary to avoid any contamination with the test item during the inhalation exposure. This restriction has been performed in this type of study historically at WIL Research and there have been no adverse consequences of the daily temporary water restriction during exposure. In addition, the health of the animal will be monitored through collection of dail y body weights and food consumption throughout the exposure period.

6.4 Basal Diet:

PMI Nutrition International, LLC Certified Rodent LabDiet ® 

## 5002 will be offered ad libitum during the study except during test item exposure. Periodic analyses of the certified feed are performed by the manufacturer to ensure that heavy metals and pesticides are not present at concentrations that would be expected to affect the outcome of the study. Results of the analyses are provided to WIL Research by the manufacturer. Feeders will be changed and sanitized once per week.

Diet restriction during the exposure period is necessary to avoid contamination of the diet with the test material during the inhalation exposure. This restriction has b een performed in this type of study historically at WIL Research and there have been no adverse consequences of the daily temporary food restriction during exposure. In addition, the health of the animal will be monitored through collection of daily body weights and food consumption through the exposure period.

7 EXPERIMENTAL DESIGN:

7.1 Animal Receipt and Quarantine:

Each animal will be inspected by a qualified technician upon receipt. Rats judged to be in good health and suitable as test animals will be immed iately

**Page 179 of 1107**WIL 65501 Page 10 of 29 25 September 2013 

## placed in quarantine for a minimum of 7 days. All rats will be initially weighed, permanently identified with a metal ear tag and receive a clinical observation. During the quarantine period, each rat will be observed twice daily for changes in ge neral appearance and behavior. For all males, the testes will be palpated at least once during the quarantine period. Prior to the start of the in

life phase, those animals judged to be suitable test subjects will be identified and receive a detailed phy sical examination.

7.2 Randomization:

At the conclusion of the quarantine period, animals judged to be suitable test subjects and meeting acceptable body weight requirements, will be assigned at random using a computer program. At that time, the animal number s and corresponding body weights will be entered into the WIL Toxicology Data Management System (WTDMS  ). A printout containing the animal numbers and individual group assignments will be generated based on body weight stratification into a block design. Animals will then be arranged into the groups according to the printout. The control group and four test item groups will consist of 12 males and 12 females each.

Any animal assigned to the study that is found dead, euthanized in extremis or exhibits abnormal clinical signs, reduced food consumption or body weight losses prior to the start of dosing may be replaced by an animal of appropriate age when possible. Replacement animals will be arbitrarily assigned (not computer randomized) to the study based on comparable body weights (if possible) with respect to the animal that was replaced.

7.3 Route and Rationale of Test Item Administration:

The route of administration will be whole body inhalation exposure because the intended use of the test item indicated that this would be a likely route of human
exposure.

7.4 Organization of Test Groups, Dosage Levels and Treatment Regimen:

7.4.1 Rationale for Dose Selection:

The dosage levels will be determined from results of a previous reproductive toxicity screen ing study ( Brooker, 2013 ). Rats were exposed to the test item for 6

- hours daily, 7 days a week from 15 days
pre

- mating through Lactation Day 10 at levels of 200, 500 and 3000 ppm. A no

- observed

- adverse

- effect level could not be established based on dose

- r elated clinical observations of underactivity, unresponsiveness, piloerection and partially closed eyelids and reduced body weight and food consumption. In addition, estrous cycles, pre

- coital intervals and

**Page 180 of 1107**WIL 65501 Page 11 of 29 25 September 2013 

## gestation periods were increased in a dose

- relate d manner and post

- natal survival and litter sizes were decreased. Based on these observations, the highest dose level selected was 175 ppm for the 6

- hour exposure and the lower dose levels were selected to assess the dose

- response relationship. The dose le vel selected for the short 5

- mintue exposure period is expected to mimic an actual exposure from a complete discharge of a fire extinguisher within the space of an aircraft, or confined space. Industry guidelines for halon alternatives either allow a 5

- min ute concentration at the cardiotox LOAEL or 5

- minute maximum concentration based on PBPK modeling

. The LOAEL of 2

- bromo

3,3,3

- trifluoropropene is 1% vol ume (Horrell , 2002). The exposure level tested will be equivalent to the test item obtaining a 1%

conc entration in the atmosphere of the enclosed aircraft or similar space. The potential effects on reproduction and development have not been tested previously for this exposure level and time.

7.4.2 Organization of Test Groups:

The following table presents the st udy group arrangement

.

Group/Number Test Item Exposure Level (ppm) Number of Animals
Males Females
1 Control Filtered Air 12 12
2 CAS:1514

- 82

- 5 50 12 12 3 CAS:1514

- 82

- 5 100 12 12 4 CAS:1514

- 82

- 5 175 12 12 5 CAS:1514

- 82

- 5 10,000 12 12



## 7.4.3 F 0 

## Treatment Regimen:

The test and control items will be administered as a daily 6

- hour whole

body inhalation exposure for Groups 1, 2, 3, and 4. The test item w ill be administered as a daily 5

- minute whole

- body exposure for Group 5. All animals will be ex posed at approximately the same time each day as follows:

7.4.3.1 Males:

F 0 

## males will be exposed for a minimum of 14 days prior to mating and continuing until the day prior to the scheduled euthanasia. The total exposure period for the F 0 

## males will encompass at least 28 consecutive days.

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## 7.4.3.2 Females:

F 0 

## females will be exposed for a minimum of 14 days prior to mating an d continuing throughout mating until gestation day 20, inclusively. F 0 

## females w i th no evidence of mating or that do not deliver will be exposed until one day prior to schedu led euthanasia on either post

- cohabitation day 25 or post

- mating day 25 , respectively.

7.4.4 Exposure Methods:

Control and t est item exposures for Groups 1, 2, 3 and 4 will be conducted in 1.0

- m 3 

## stainless

- steel and glass exposure chamb ers and Group 5 will be exposed in a 0.5

- m 3 

## stainless

- steel and glass exposure chamber

. Four chambers will be dedicated to each of the four test item exposure groups, while the f ifth chamber will be dedicated to the control group. The chambers will be op erated under dynamic conditions, at a slight negative pressure (ca. 0.5 in. of water) with at least 12 to 15 air changes per hour. Oxygen content of the exposure atmosphere will be at least 19% and will be documented during the pre

- st udy methods developme nt phase. Temperature and relative humidity during exposures will be measured at least once every hour for each chamber and the daily average will be between 19oC and 25 oC, and 30% to 70%, respectively.

All animals will be housed in normal animal colony ro oms during

non

- exposure hours. For each day’s exposure, the animals will be transferred to exposure caging, transported to the exposure chamber room, exposed for the requisite duration and returned to their home cages. Animal cage batteries will be rotat ed through the various possible chamber locations on a daily basis.

7.5 Generation of Exposure Atmospheres:

Appropriate equipment and procedures for generation of test substance atmospheres at the required concentrations will be determined during the
pre

- study method development. If appropriate for the test substance and the selected exposure levels, vapors will be generated by bubbling nitrogen through minimally heated test substance in an appropriate flask. A suitable heating element (tape or mantle) will be used to provide a stable temperature, if heating is required. Additional vaporization approaches, such as a heated glass

- bead column type vaporization system are available, and may be used, if required. Test substance and vaporization nitrogen are metered to the column, and nitrogen enters below the glass beads while test substance is deposited on the beads. Vaporization occurs as the test substance flows down over the beads and nitrogen moves up through the beads. The concentrated vapors will be piped t o

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## the chamber inlet where the concentration will be reduced to the desired level by mixing with chamber ventilation air. The atmosphere for the control chamber will be generated using the same procedure except that no test substance will be added. The det ails of the selected and validated method will be included in the final report.

7.6 Characterization of Exposure Atmospheres:

7.6.1 Nominal Exposure Concentrations:

Nominal exposure concentrations will be calculated for each day’s exposure using the following formul a:

ppm = Wt. • Mol. Vol. • 10 6 

## MW • Ch. Flow • Exp. Dur.

Where: Wt. = the weight of test substance used during a given day’s exposure, grams Mol. Vol. = Molar volume at 730 mm Hg and 21oC 10 6


## = ppm conversion factor MW = molecular weight Ch. Flow = Daily average chamber flowrate for a given day, in L/min Exp. Dur. = Duration of a given days’ exposure, in minutes

7.6.2 Actual Exposure Concentrations:

Actual concentrations of the test substance in the exposure atmospheres will be determined at least at hourly intervals for each chamber using an appropriate auto mated gas chromatography method.

A ll chamber concentration data will be collected automatically through the use of the Inhalation Exposure Data Collection System (WINH) and a personal computer

. Measurements of test substance concentration will commence after the t 9 9 

## start

- up period. At each sampling, chamber temperature, relative humidity and airflow will be recorded. Daily results will show the mean analyzed concentration ± the standard deviatio n.

7.6.3 Aerosol Monitoring:

The control and high

- concentration chambers will be monitored for aerosol formation during method development. A light

- scattering

**Page 183 of 1107**WIL 65501 Page 14 of 29 25 September 2013 

## aerosol photometer (MIE, Inc., Billerica, MA, or equivalent) will be used for this evaluation

.

7.7 Determi nation of Estrous Cycles:

Daily vaginal lavages will be performed to determine the stage of estrus beginning 10 days prior to treatment and continuing until evidence of mating is observed. Lavaging will continue for those females with no evidence of matin g until termination of the mating period. Estrous cycle determination will be conducted on all females, including stock, during the pretest period in the event animal replacement is necessary.

7.8 F 0 

## Breeding:

After a minimum of 14 days of exposure, one female will be cohabitated with one male rat of the same treatment group, avoiding sibling mating (Charles River Laboratories will supply non litter mates), in a suspended wire mesh cage for mating. Detection of mating will be confirmed by the appearance of a v aginal copulatory plug or by evidence of sperm in a vaginal lavage

. Vaginal lavages will be performed daily during the mating period until evidence of mating is observed. After confirmation of mating, the female will be returned to an individual plastic m aternity cage and the day will be designated as day 0 of gestation.

A maximum of 14 days will be allowed for mating. After 14 days of mating, any females who have not shown evidence of breeding will be placed in a plastic maternity cage containing nesting material.

7.9 F 0 

## Parturition and Lactation and F 1 

## Litters:

The day parturition is initiated will be designated as day 0 of lactation. Any difficulties at the time of parturition will be recorded. When parturition is judged to be complete, the sex of each pu p will be determined, pups will be examined for gross malformations and the number of stillbirths and live pups will be recorded. Any changes or abnormalities in nesting and nursing behavior will be recorded. The dam and litter will remain together until postnatal day (PND) 4.

7.10 Identification of F 1 

## Litters:

Upon completion of delivery, all pups will be individually identified by tattoo markings applied to the digits. Standardization for litter size will not be performed.

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## 7.11 General Observations During the Experimental Period:

7.11.1 Parental Appearance and Behavior:

Each parental rat (F 0 

## ) will be observed twice daily for moribundity and mortality, once in the morning and once in the afternoon. A detailed physical examination will be conducted weekly. Mortality a nd all signs of overt toxicity will be recorded on the day observed. The Observations shall include, but are not limited to, evaluations for changes in appearance of the skin and fur, eyes and mucous membranes, respiratory, circulatory, autonomic and cent ral nervous systems,
somatom otor activity and behavior. During the period of expected parturition, the dams will be observed twice daily for dystocia, prolonged labor, delayed labor or other difficulties at parturition. All animals will also be observed on the day of necropsy and findings will be recorded.

During the exposure period, each animal will be observed approximately 1 hour following each exposure for findings that are potentially related to treatment or that might change before the next schedule d observation. Additional post

- exposure observations may be necessary and will be do cumented in the study records.

7.11.2 Parental Body Weights:

All animals will have a final body weight recorded on the day of euthanasia

.

7.11.2.1 Males:

Recorded individually on a weekly basis, beginning on the first day of exposure , until euthanasia.

7.11.2.2 Females:

Recorded individually on a weekly basis, beginning on the first day of exposure until evidence of copulation is observed or until euthanasia (for f emales without evidence of mating) 

## . Following evidence of copulation, body weights will be recorded on gestation days 0, 4, 7, 11, 14, 17 and 20 and lactation days 1 and 4. For females with evidence of mating that do not deliver, body weights will have bee n recorded on the presumed gestation days indicated above and then on the day of scheduled euthanasia (post

- mating day 25).

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## If a female is determined to have completed parturition at the morning parturition examinations, a lactation day 0 weight will be r ecorded for the female, and the weight will be used for calculation of dose volume. The lactation day 0 weights will not be summarized or analyzed statistically but will be included on the individual animal data tables.

7.11.3 Parental Food Consumption :

Individu al food consumption will not be recorded during the breeding period because the animals are cohabitated at that time.

7.11.3.1 Males:

Recorded individually on a weekly basis, beginning on the first day of exposure , until euthanasia.

7.11.3.2 Females:

Recorded individually o n a weekly basis beginning on the first day of exposure , until the start of the mating period. Individual food consumption will be recorded on the day evidence of copulation is observed (GD 0) and on gestation days 4, 7, 11, 14, 17 and 20 and lactation da ys 1 and 4.

For females with no evidence of mating, individual food consumption will continue to be recorded on a weekly basis following the end of the mating period until euthanasia. For females that do not deliver, individual food consumption will have been recorded on the presumed gestation days and on the day of scheduled euthanasia (post

- mating day 25).

7.11.4 Parental Water Consumption:

Individual water consumption will not be recorded during the breeding period because the animals are cohabitated at that t ime.

7.11.4.1 Males:

Recorded individually on a daily basis beginning on the first day of exposure , until euthanasia for all males

. Water consumption will be reported on a weekly basis.

**Page 186 of 1107**WIL 65501 Page 17 of 29 25 September 2013



## 7.11.4.2 Females:

Recorded individually on a daily basis beginning on the first day of exposure, until euthanasia for all females. For females with evidence of mating and delivery, water consumption will be reported on a weekly basis during the pre

- mating period and on gestation days 4, 7, 11, 14, 17 and 20 and lactation days 1 and 4.

For females with no evidence of mating , water consumption will be reported on a weekly basis and females that do not deliver will have water consumption recorded throughout presumed gestation as indicated above and on the day of scheduled euthanasia (post

mati ng day 25).

7.11.5 Examination of Offspring:

7.11.5.1 Appearance and Behavior:

All pups will be observed daily for general appearance and behavior and survival during lactation. A detailed physical examination will be recorded for each pup on PND 1 and 4. Any abnormali ties in nesting and nursing behavior will be recorded and pups will be sexed on PND 0 and 4.

7.11.5.2 Body Weights:

Each pup will be weighed on PND day 1 and 4.

7.11.5.3 Pup Deaths:

Moribund pups will be euthanized by an intraperitoneal injection of sodium pentobarbital. S tillborn pups, pups found dead, and any pups that are euthanized in extremis will be dissected (including the heart and the brain examined by a mid

- coronal slice) by a technique described by Stuckhardt and Poppe (1984). If a skeletal anomaly is suspected, the pup will be eviscerated, cleared and stained with Alizarin Red S as described by Dawson (1926) and examined. Any findings will be recorded as either developmental variations or malformations. Representative specimens with malformations may be preser ved in 10% neutral buffered for malin at the discretion of the Study D irector.

**Page 187 of 1107**WIL 65501 Page 18 of 29 25 September 2013



## 7.12 Euthanasia of F 0 

## Generation:

7.12.1 Females:

7.12.1.1 Females Which Deliver:

On lactation day 4, all F 0 

## females that delivered will be euthanized by carbon dioxide inhalation. The abdominal, pelvic and thoracic cavities will be opened and the contents examined. The number of former implantation sites and corpora lutea will be recorded. Organ weights will be collected and tissues preserved as described in Section 8.

7.12.1.2 Females Which Fail to Deli ver:

On post

- mating day 25 (females with evidence of copulation) or post

- cohabitation day 25 (females without evidence of copulation), the F 0 

## females which fail to deliver will be euthanized by carbon dioxide inhalation. The abdominal, pelvic and thoracic cavities will be opened and the contents examined. Uteri which appear nongravid by macroscopic examination will be opened and placed in a 10% ammonium sulfide solution (Salewski, 1964) for detection of early implantation loss. Organ weights will be c ollected and tissues preserved as described in Section 8 with the exception of any ammonium sulfide stained uterus, which will be discarded.

7.12.1.3 Females with Total Litter Loss:

Females with total litter loss will be euthanized by carbon dioxide inhalation on the same day. The number of former implantation sites and corpora lutea will be recorded. Organ weights will be collected and tissues preserved as d escribed in Section 8

.

7.12.1.4 F 0 

## Deaths and Animals Euthanized in Extremis :
Females not surviving until the sch eduled euthanasia will be necropsied as described in Section 8. Animals not expected to survive to the next observation period (moribund) will be euthanized by carbon dioxide inhalation and necropsied as described in Section 8, with the following exceptio ns: Organ weights will not be collected and t he number and location of implantation sites or scars and corpora lutea will be recorded for females dying or euthanized during gestation and lactation. Tissues will be preserved as described in Section 8. Vi able

**Page 188 of 1107**WIL 65501 Page 19 of 29 25 September 2013 

## fetuses will be euthanized by a subcutaneous injection of sodium pentobarbital in the scapular region. Recognizable fetuses will be examined externally for gross abnormalities. Representative specimens with malformations may be preserved in 10% neut ral

buffered formalin, at the discretion of the study director. For females found dead or euthanized in extremis during lactation, all pups will be examined externally, euthanized by an intraperitoneal injection of sodium pentobarbital and necropsied

acco rding to Section 7.11 .5 .3.

7.12.2 Males:

Following completion of the mating period (minimum of 28 daily doses), all F 0 

## males will be euthanized by carbon dioxide inhalation

, assessed for spermatogenesis, and subjected to a gross necropsy and tissues preserved as described in Section 8.

Males not surviving until the scheduled euthanasia will be necropsied as described in Section 8. Any males not expected to survive to the next observation period (moribund) will be euthanized by carbon dioxide inhalation and also necropsied as described in Section 8. Organ weights will not be collected and spermatogenesis will not be performed on found dead or euthanized early animals.

7.13 Euthanasia of F 1 

## Generation:

On PND 4, the F 1 

## pups will be euthanized via an intraperitoneal inj ection of sodium pentobarbital and discarded.

7.14 Spermatogenesis Evaluations:

The following quantitative assessment of the process of spermatogenesis will be performed on all males at study termination.

If the left testis or epididymis is noted with a gross l esion, these organs will not be homogenized. Instead, the right testis and epididymis will be used for enumeration of cauda epididymal and testicular sperm and sperm production rate and the left testis and epididymis will be used for motility/viability and morphology assessments as well as for preservation in modified Davidson’s solution for subsequent microscopic examination.

7.14.1 Motility/Viability Assessment:

Immediately after euthanasia, the reproductive tract of the male will be exposed via a ventral mid

- li ne incision. The right epididymis will be excised and weighed separately. An incision will be made in the distal

**Page 189 of 1107**WIL 65501 Page 20 of 29 25 September 2013 

## region of the right cauda epididymis, and the cauda will be placed in a beaker containing Dulbecco's phosphate

- buffered saline (maintained at approximately 37oC) with 10 mg/mL Bovine Serum Albumin (BSA). A small sample of the diluted sperm will be loaded into a 100

- μm chamber for determination of motility. Because sperm motility can be affected by temperature shock, all slides and diluents wi ll be warmed prior to use in an incubator, and motility determinations will be performed under constant temperature (approximately 37oC) using the Hamilton

- Thorne HTM

- IVOS Version 14 (or higher) computer

- assisted sperm analysis (CASA) system. Analysis of at least 200 motile and nonmotile spermatozoa (if possible) per animal in all exposure groups will be performed by the analyzer. The percent motile and percent progressively motile will be reported. The right epididymis will then be preserved in accordanc e with Section 8.1.

7.14.2 Morphology Assessment:

Sperm morphology will be evaluated by a modification of the
wet

- mount evaluation technique (Linder et al, 1992). Abnormal forms of sperm (double heads, double tails, microcephalic or megacephalic,

etc. ) from a di fferential count of 200 spermatozoa (if possible) per animal in all groups will be recorded.

7.14.3 Enumeration of Epididymal and Testicular Sperm and Sperm Production Rate (SPR):

The left testis and cauda epididymis will be weighed, homogenized and evaluated for sperm numbers and the sperm production rate will be calculated (Blazak et al, 1985) utilizing the Hamilton

- Thorne CASA system. The homogenized sample will be mixed with a DNA

- specific fluorescent dye to allow identification of the sperm under fluorescent illumination. The right testis and epididymis , and the remainder of the left epididymis, will be preserved in modified Davidson’s fixative for subsequent microscopic examination as described in Section 8.3.

8 ANATOMIC PATHOLOGY:

8.1 Macroscopic Examination:

A complete necropsy will be conducted on all F 0 

## parental animals dying spontaneously, euthanized in extremis (by carbon dioxide inhalation) or at termination. This will include examination of the external surface, all orifices, the cranial cavity, the exte rnal surface of the brain and the thoracic, abdominal and pelvic cavities including viscera. For F 0 

## females, the number of former implantation sites and corpora lutea will be recorded.

**Page 190 of 1107**WIL 65501 Page 21 of 29 25 September 2013 

## At the time of necropsy, the following tissues and organs will be coll ected and placed in 10% neutral

- buffered formalin (except as noted):

Brain Coagulating gland Kidneys Liver Lungs Mammary glands Ovaries a 

## and oviduct (2) Pituitary gland Prostate gland Seminal vesicles (2) Spleen Testes with epididymides (2) b,c



## and vas deferens Uterus d 

## with cervix and vagina All gross lesions e



### a

- Ovaries will be fixed in 10% neutral

- buffered formalin for approximately 48 hours following which all ovaries will be transferred to 70% Ethanol. b

- Testis (right) and epididymis (right and remainder of left) will be fixed in modified Davidson’s solution. Both testes and epididymides from males found dead or euthanized in extremis will be fixed in modified Davidson’s solution. Care will be taken to ensure separation be tween the left and right organs.

c

- If the left testis or epididymis is noted with a gross lesion, the left testis and epididymis will be fixed in modified Davidson’s solution and the right testis and epididymis will be homogenized according to section 7.18.3. d

- Any uterus stained in 10% ammonium solution for detection of implantation sites will be discarded and not preserved in 10% neutral buffered formalin.

e

- Representative sections of corresponding organs from a sufficient number of

co ntrols will be retained for comparison, if possible.



## 8.2 Organ Weights:

The following organs will be weighed from all F 0 

## parental animals euthanized at scheduled termination. Organ

- to

- final

- body weight and organ

- to

- brain weight ratios will be evaluated.

Brain Epididymides* (total and caudal) Kidneys Liver Lungs Ovaries (with out oviducts) Pituitary gland Spleen Testes*
*

- These paired organs will be weighed separately. Care will be taken to ensure separation be tween the left and right organs

.



## 8.3 Microscopic Examination:

Microscopic examination will be performed on the following tissues from all F 0 

## parental animals from the control and high

- dose groups and from all parental animals dying spontaneously or euthanized in extremis

. All g ross lesions will be exami ned microscopically, irrespective of group.

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## T issues and organs fixed in 10% neutral

- buffered formalin, or other fixatives (as noted in Section 8.1) from animals scheduled for microscopic examination (as noted above) will be embedded in paraffin, sectioned and stained with hematoxylin and eosin (H&E) for microscopic evaluation

. Sections of the testes and epididymides will also be stained with Periodic Acid

- Schiff’s stain (PAS) and hematoxylin. Tissues and organs from all other animals will be maintained in the appropriate fixatives in the event that additional histopathology is requested by the Sponsor.

Cervix Coagulating gland Epididymides a ,b 

## Lungs Mammary glands (female only) Ovaries c,d 

## Pituitary gland Prostate gland Seminal vesicles Spleen Testes a ,b


## Uterus Vagina Vas deferens All gross (internal) lesions

a

- Sections of 2

- 4 microns of the testis (transverse) and epididymis (longitudinal) will be stained in PAS and hematoxylin in addition to routine hematoxylin and eosin staining. b

- If the left testis or epididymis is noted with a gross lesion, the left testis and epididymis will be fixed in modified Davidson’s solution and the right testis and epididymis will be homog enized according to section 7.14 .3.

c

- All ovaries will be paraffi n embedded. Five (5) sections will be taken approximately 100 μ m apart from the inner third of each ovary from all the F 0 

### females in the control and high dose groups at scheduled termination and for any females suspected of reduced fertility. In addition, a single section will be taken for a qualitative bilateral evaluation of each ovary. A quantitative histopathologic evaluation of multiple sections will be conducted. This examination will include enumeration of the total number of primordial follicles according to the methods of Bolon et al (1997), Bucci et al (1997) and Picut et al (2008). d

– For females found dead, or euthanized in extremis , a single section from each ovary will be qualitatively evaluated.



## Microscopic examination may be extended t o other organs/tissues, groups if a potential target organ is noted based on histopathological examination of tissues from the high

- dose group or other parameters after approval of the Sponsor and at additional cost)

. Ovarian tissues will be shipped to the attention of the Principal Investigator (Ovarian Histology) at the address provided in Section 2. This is a WIL

designated test site. Histology slide preparation will be conducted following the Standard Operating Procedures of WIL Research at Hillsborough, and in accordance with the Protocol and applicable GLPs. The Principal Investigator (Ovarian Histology), will be responsible for all delegated

- phase activities. Any

**Page 192 of 1107**WIL 65501 Page 23 of 29 25 September 2013 

## deviations from the GLPs or Protocol and any study specific S OP deviations will be reported to the Study Director.

9 DURATION OF STUDY:

The two generations to be studied (parental animals and first generation offspring) will be termed F 0 

## and F 1 

## , respectively. The conduct of this study will require approximately 10 we eks for acclimation, mating, gestation and lactation of the F 0 

## generation.

10 STATISTICAL METHODS:

All analyses will be two

- tailed for significance levels of 5% and 1%. All means will be presented with standard deviations. All statistical tests will be perf ormed by a computer with appropriate programming as referenced below. Following completion of the mating period, d ata from nongravid females will be excluded from calculation of means and from comparative statistics. The litter, rather than the pup, will be considered as the experimental unit.

10.1 Parental In

- Life Data:

Continuous data variables [mean body weights, body weight gains and food consumption at each interval], pre

- coital intervals, mean estrous cycle length, gestation length, former implantation si tes, corpora lutea and unaccounted

- for sites will be subjected to a parametric one

- way analysis of variance (ANOVA) (Snedecor and Cochran, 1980) to determine intergroup difference. If the results of the ANOVA are significant (p<0.05), Dunnett's test (Dunn ett, 1964) will be applied to the data to compare the treated groups to the control group.

Male and female mating, fertility, copulation and conception indices of the treated groups will be compared to the control group using the Chi

- square test with Yates ' correction factor (Hollander and Wolfe, 1999).

10.2 Litter Data:

The mean litter proportions (% per litter) of pup viability during the postnatal period and sex ratio at birth will be subjected to the Kruskal

- Wallis nonparametric ANOVA test (Kruskal and Walli s, 1952) to determine intergroup difference. If the results of the ANOVA are significant (p<0.05), the Dunn’s Test (Dunn, 1964) will be applied to the data to compare the treated groups to the control group. Mean litter weights, live litter size, mean pu p body weights and mean pup body weight gains and number of pups born will be subjected to the parametric ANOVA test (Snedecor and Cochran, 1980) and Dunnett's test (1964) as described above with the litter representing the experimental unit.

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## 10.3 Histopatholog y and Organ Weight Data:

Histopathological findings of each treated group will be compared to those of the control group by the Fisher’s Exact test (Steel and Torrie, 1980). Organ weights (absolute and relative to body weights and relative to brain weights) and mean number of ovarian primordial follicles will be subjected to a parametric ANOVA test (Snedecor and Cochran, 1980) and Dunnett's test (1964) as described above.

10.4 Spermatogenic Endpoint Evaluations:

The percentage of motile spermatozoa and pe rcentage of sperm with normal morphology will be subjected to the Kruskal

- Wallis nonparametric ANOVA test (1952) followed the Dunn’s Test (1964) as described above. Epididymal and testicular sperm numbers and sperm production rates will be subjected to a parametric ANOVA test (Snedecor and Cochran, 1980) and Dunnett's test (1964) as described above.

11 QUALITY ASSURANCE:

The study will be audited by the WIL Research Quality Assurance Department while in progress to assure compliance with Good Laboratory Pract ice Regulations, adherence to the protocol and to WIL Standard Operating Procedures. The protocol, protocol amendments, raw data, draft report and final report will be audited by the WIL Research Quality Assurance Department prior to submission to the Spo nsor to assure that the final report accurately describes the conduct and the findings of the study. This study will be conducted in compliance with the EPA/TSCA (40 CFR Part 792 ) Good Laboratory Practice Standards and the OECD [C(97) 186/Final] Principle s of Good Laboratory Practice

. Histology slide preparation for ovarian primordial follicle evaluation will be conducted following the Standard Operating Procedures of WIL Research at Hillsborough, and in accordance with the Protocol and GLPs. Quality Assurance monitoring of these analyses for Protocol, SOP and GLP compliance is the responsibility of WIL Research at Hillsborough . Inspection reports will be supplied to the Study Director. Upon completion of the prescribed activities, WIL Research at Hillsborough will provide a signed Quality Assurance Statement to the Study Director which will be included in the final report.

This study will be included on the WIL Research master list of regulated studies.

12 RECORDS TO BE MAINTA INED:

All or iginal raw data records, as defined by WIL Research SOPs and the applicable GLPs, will be stored as described in Section 13 in the WIL Research Archives

.

**Page 194 of 1107**WIL 65501 Page 25 of 29 25 September 2013



## 13 WORK PRODUCT:

The Sponsor will have title to all documentation records, raw data, specimens and other work product generated during the performance of the study. Any remaining samples ( e.g. formulation or blood/plasma/serum) will be discarded after issuance of the Final Report . All work product generated at WIL Research at Hillsborough will be returned t o WIL Research. All work product, including raw paper data, pertinent electronic storage media and specimens, will be retained at no charge for six months following issuance of the final report in the WIL Research Archives . Thereafter, WIL Research will charge a monthly archiving fee for retention of all work product. All work product will be stored in compliance with regulatory requirements.

Any work product, including documents, specimens, and samples, that are required by this protocol, its amendments , or other written instructions of the Sponsor, to be shipped by WIL Research to another location will be appropriately packaged and labeled as defined by WIL’s SOPs and delivered to a common carrier for shipment. WIL Research will not be responsible for shipment following delivery to the common carrier.

All work product generated at a performing laboratory will be retained at an appropriate archive facility as designated by the SOPs of the performing laboratory.

14 REPORTS:

The final report will contain a su mmary, test item information, methods and procedures, appropriate individual animal and summary data tables, WIL Research Historical Contro l Data, supporting sub

- reports, a copy of the protocol and amendment(s), if any, and an interpretation and discussion of the study results. The final report will be comprehensive and shall define level(s) inducing toxic effects as well as no

- effect level(s) under the conditions of this investigation. The report will contain all information necessary to conform to curre nt OECD specifications.

WIL Research will submit an electronic copy (PDF and MS Word copy of the report text for editing and comments) of the audited draft report in a timely manner upon completion of data collection prior to issuance of the final report. It is expected that the Sponsor will review the draft report and provide comments to WIL Research within a two

- month time frame following submission. WIL Research shall provide a revised draft report that incorporates the Sponsor's reasonable revisions and suggestions. One revision will be permitted as part of the cost of the study; additional changes or revisions may be made, at extra cost. WIL Research shall submit the final report within two weeks of receiving authorization to finalize the report from the Sponsor. If the Sponsor’s comments and/or authorization to finalize the report have not been received at WIL Research within one year following submission of the draft report, WIL Research may elect to finalize the report following appropriate written notification to the Sponsor. An electronic copy (bookmarked and hyperlinked PDF)

**Page 195 of 1107**WIL 65501 Page 26 of 29 25 September 2013 

## of the final report will be provided; requests for paper copies of the final report may result in additional charges

.

15 ANIMAL WELFARE ACT C OMPLIANCE:

This study will comply wi th all applicable sections of the Final Rules of the Animal Welfare Act (AWA) regulations (9 CFR). The protocol will be reviewed by the WIL Institutional Animal Care and Use Committee (IACUC) prior to commencement of study specific activities. The Sponso r should make particular note of the following:

• The Sponsor Representative's signature on this protocol documents for the Study Director the Sponsor's assurance that the study described in this protocol does not unnecessarily duplicate previous experiments

.

• Whenever possible, procedures used in this study have been designed to avoid or minimize discomfort, distress or pain to animals. All methods are described in this study protocol or in written laboratory Standard Operating Procedures.

• Animals that exper ience severe or chronic pain or distress that cannot be relieved will be painlessly euthanized as deemed appropriate by the veterinary staff and Study Director. The Sponsor will be advised by the Study Director of all circumstances which could lead to thi s action in as timely a manner as possible.

• Methods of euthanasia used during this study are in conformance with the above

- referenced regulation.

• The Sponsor/Study Director has considered alternatives to procedures that may cause more than momentary or sli ght pain or distress to the animals and has provided a written narrative description (AWA covered species) of the methods and sources used to determine that alternatives are not available.

16 PROTOCOL MODIFICATIO N:

Modification of the protocol may be accomplished during the course of this investigation. However, no changes will be made in the study design without the verbal or written permission of the Sponsor. In the event that the Sponsor verbally requests or approves a change in the protocol, such changes will be made by appropriate documentation in the form of protocol amendment. All alterations of the protocol and reasons for the modification(s) will be signed by the Study Director and the Sponsor Representative.

17 REFERENCES:

Blazak, W.F.; Ernst, T.L.; Stewart, B.E. Potential indicators of reproductive toxicity: testicular sperm production and epididymal sperm number, transit time and motility in Fischer 344 rats. Fundamental and Applied Toxicology 1985, 5 (6 Pt. 1), 1097

- 110 3.
**Page 196 of 1107**WIL 65501 Page 27 of 29 25 September 2013


## Bolon, B., Bucci, T.J., Warbritton, A.R., Chen, J.J., Mattison D.R. and Heindel, J.J. Differential follicle counts as a screen for chemically induced ovarian toxicity in mice: Results from continuous breeding bioassays. Fundam. Appl. Toxicol. 1997, 3 9, 1

- 10.

Brooker, A.J. 2

- bromo

- 3,3,3

- trifluoropropene: Reproductive/ Developmental Toxicity Screening Study in the CD Rat by Inhalation Administration. Huntingdon Life Sciences Study: WAG0015

. 2013

.
Bucci, T.J., Bolon, B., Warbritton, A.R., Chen, J.J., and Heindel, J.J. Influence of Sampling on the reproducibility of ovarian follicle counts in mouse toxicity studies. Reprod. Toxicol. 1997, 11(5), 689

- 696.

Dawson, A.B. A note on the staining of the skeleton of cleared specimens with Alizarin Red S. Stain Technology 1926, 1, 123

- 124.

Dunn, O.J. Multiple comparisons using rank sums. Technometrics 1964, 6(3), 241

- 252.

Dunnett, C.W. New tables for multiple comparisons with a control. Biometrics 1964, 20, 482

- 491

Hollander, M.; Wolfe, D.A. Nonparametric Statistical Methods, 2nd ed.; Hollander, M., Wolfe, D.A., Eds.; John Wiley and Sons, Inc.: New York, NY, 1999; p 468.

Horrell, P.J. Agent 873: An Inhalation Study to Investigate the Cardiac Sensitisation Potential in the Beagle. Huntingdon Life Sciences , Ltd. Study: AAS 001/014630. 2002.

Kruskal, W.H.; Wallis, W.A. Use of ranks in one

- criterion variance analysis. Journal of the American Statistical Association 1952, 47, 583

- 621.

Linder, R.E.; Strader, L.F.; Slott, V.L.; Suarez, J.D. Endpoints of sperma totoxicity in the rat after short duration exposures to fourteen reproductive toxicants. Reproductive Toxicology 1992, 6, 491

- 505.

Picut, C.A.; Swanson, C.L.; Scully, K.L.; Roseman, V.C.; Parker, R.F.; Remick, A.K. Ovarian Follicle Counts Using Prolifera ting Cell Nuclear Antigen (PCNA) and Semi

Automated Image Analysis in Rats. Toxicol Pathol. 2008 May 8.

Salewski, E. Färbemethode zum makroskopischen Nachweis von Implantationsstellen am Uterus der Ratte. [Staining method for a macroscopic test for impla ntation sites in the uterus of the rat]. Naunyn

- Schmiedebergs Archiv für Experimentelle Pathologie und Pharmakologie 1964, 247, 367.

Snedecor, G.W.; Cochran, W.G. One Way Classifications; Analysis of Variance. In Statistical Methods, 7th ed.; The Iowa State University Press: Ames, IA, 1980;
pp 215

- 237.

**Page 197 of 1107**WIL 65501 Page 28 of 29 25 September 2013


## Steel, R.G.D.; Torrie, J.H. Principles and Procedures of Statistics, A Biometrical Approach, 2nd ed.; McGraw

- Hill Book Company: New York, NY, 1980; pp 504

- 506.

Stuckhardt, J.L.; Poppe, S.M. Fresh visceral examination of rat and rabbit fetuses used in teratogenicity testing. Teratogenesis, Carcinogenesis and Mutagenesis 1984, 4, 181

- 188.

**Page 198 of 1107**

### WIIh5501 

### Page 29 of29 

### 25 

### September2013



# 18 

# PROTOCOL 

# APPROVAL:

Sponsor 

# approval 

# received via 

# email on 24 September 20 

# 1 

# 3.

%radfoxd 

# Colton Sponsor Representative



# WIL Resestrch

~adnye 

# L. 

# Edwards, 

# BS Study 

# Dktor 

# ad +t

Date



# a/Sepat3
Date

**Page 199 of 1107**

## WI L

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene

American Pacific Corporation



# APPENDIX **B**

Certificate of Analy sis (Sponsor

- Provided Data)

**Page 200 of 1107**

# AMPAC" 

# HALOTRON

Phone (435) 865 

# - 5000 AMEFUCAN PACIFIC CORPORATION 

# - UTAH OPERATIONS 10622 

### W 6400 

### N CEDAR CITY, UTAH 84720



### Fax (435) 865 

### - 5029



## CERTIFICATE OF ANALYSIS

MATERIAL:

CUSTOMER:

QUANTITY:

LOT #:



### P.O. 

### NUMBER:

O.I.D. 

### NUMBER:

LINE ITEM NUMBER:

SPECIFICATION:

DATE 

### OF MANUFACTURE;

DATE:



### PROPERTY Assay

Acidity (by weip,ht 

### as HBr)

Non Volatile Residue

Appearance (Color)

Appearance (Clarity) Stabilized 

### 2-Bromo-3,3,3-trifluoropropene (2-BTP)

WIL Research

180 Ib

WNCC-BTP111128

NA



### NA

NA

AMP-QSP-072, Rev 01

November 20 

### 1 1

22 October 2013



### CERTIFIED 

### VALUE >99.4

11



### <I

1400

Light Yellow, < 200



### < 15 15 

### ppm Max

3 pprn 

### Max

4000 ppm Max

200 Color Units 

### Max

15 NTU Max

The signing of this document by an 

### authorized representative of the Quality Assurance department indicates that the material is in conformance with specified requirements. Information contained in this report applies only to the material related to the specified lot number. This report shall not be reproduced, except in full, without written approval from AMPAC.

Where references to NELAC 

### accreditation is made on any 

### certificate or report, all requirements of the associated standard regarding information on the report will be 

### met.

Doc ID: 002910 HI-LAB-090-FM-06 

### Director Analvtical Laboratories Date Title

Rev: 00 Effective Date: 06 November Pag 

### 1 2007 of I



### CERTIFIED COPY



## Page 201 of 1107

# AMPAC" 

# HALOTRON

Phone (435) 865 

# - 5000 

### AMERICAN 

### PACIFIC CORPORATION 

# - UTAH 

### OPERATIONS 10622 

### W 6400 N 

### CEDAR CITY, UTAH 84720



### Fax (435) 865 

### - 5029



## CERTIFICATE OF ANALYSIS

CUSTOMER:

QUANmr:

LOT # :



### P.O. 

### NUMBER:

O.I.D. 

### NUMBER:

LINE ITEM 

### NUMBER:

SPECIFICATION:



### DATE OF MANUFACTLTRE:

DATE:



### PROPERTY Assay

Water-ppm

Acidity (by 

### weight as HBr)



### Non Volatile Residue

Appearance (Color)

Appearance (Clarity) Stabilized 2-Bromo-3,3,3-trifluoropropene 

### (2-BTP)

Huntingdon 

### Life Sciences Ltd.

2827 

### kg

WNCC-BTP1111 28

72032.2

170588

AMP-QSP-072, 

### Rev 00



### November 20 1 1

02 

### April 2012



### CERTIFIED 

### VALUE

960

Light Yellow, < 200 

### SPECITICATION 99.0% 

### Min



### 15 ppm 

### Max

3 

### ppm 

### Max

4000 

### ppm 

### Max

200 

### Color Units 

### Max

15 

### NTU Max

The signing of this document by 

### an authorized representative of the Quality Assurance 

### department indicates that 

### the material 

### is in 

### conformance with specifid 

### requ~~enp..Info,gation contgiqed in 

### this 

### repofl applies 

### only to 

### the 

### mateal related to 

## the specjfied 

### lot nqmbq. 

### This report shall not 

### be reproduced, except in 

### fill, without written approval from WAC. Where 

### references to NELAC 

### accreditation is made on any 

### certificate or report, 

### all requirements of the associated standard regarding information on the report will 

### be met.

Doc 

### ID: 002910 HI-LAB-090-FM-06 Rev: 00 

### Director 

### Analytical 

### Laboratories Title

Effective Date: 06 November 2007 Page 1 of 

### I



## Page 202 of 1107

## WI L

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene

American Pacific Corporation



# APPENDIX **C**

Exposure Atmosphere Generation Report (WIL Research)

**Page 203 of 1107**

## An Inhalation Reproduction/Developmental Toxicity Screening Study of 2

- Bromo

- 3,3,3

- Trifluoropropene in Rats

Exposure Atmosphere Generation Report

Date Issued

1 4 March 2014

Date Amendment Issued

19 March 2014

WI L Research Inhalation Departm ent WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Page 1 of 9
**Page 204 of 1107**

## WIL-65501 American Pacific Corporation

AMENDMENT TO THE 

# FINAL INHALATION REPORT

Inhalation Table 2, Inhalation Table 

## 4, and Inhalation Table 6 Original Report Pages: 27,28,31,32,35,36 Amendment to Final Inhalation Report Pages: 4,5,6,7,8,9


# m: Replaced Inhalation Table 2, Inhalation Table 4, 

## and Inhalation Table 6.



## Reason for Chanze: Updated Inhalation Table 2, 

## Inhalation Table 4, 

## and Inhalation Table 

# 6

were not included in the final inhalation report

The amendment did not entail generation of new data, revision of 

## calculations, 

## or modification of


## previously submitted data. The revisions to 

## the inhalation final report included in the

amendment may have resulted in changes in pagination in the inhalation final report; any potential changes in pagination are not addressed in this amendment.

The signature below certifies that the 

## revised pages have been reviewed and approved by the

Lead Technician.



# d.p.: l!! 

# *-

l4MkRLolY Arthur J. 

## Stephens, BA Date Biologist, Inhalation Toxicology Lead Technician



# - Page2of9



## Page 205 of 1107

# R **EV ISED**  

# P **AGES**



## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Page 3 of 9
**Page 206 of 1107**INHALATION TABLE 2

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN CHAMBER TEMPERATURE [DEGREES CELSIUS]

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 0 PPM 10000 PPM DATE CHAMBER: 5A 5B

----------------------------------------------------------------------------------------------------------------------------------- 10/14/13 23 22 10/15/13 23 22 10/16/13 23 23 10/17/13 25 25 10/18/13 23 22 10/19/13 23 22 10/20/13 22 22 10/21/13 23 23 10/22/13 23 22 10/23/13 23 23 10/24/13 25 23 10/25/13 24 23 10/26/13 24 22 10/27/13 24 23 10/28/13 23 23 10/29/13 23 23 10/30/13 23 23 10/31/13 23 24 11/01/13 24 23 11/02/13 24 22 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Page 4 of 9**Page 207 of 1107**INHALATION TABLE 2

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN CHAMBER TEMPERATURE [DEGREES CELSIUS]

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 0 PPM 10000 PPM DATE CHAMBER: 5A 5B

----------------------------------------------------------------------------------------------------------------------------------- 11/03/13 24 23 11/04/13 24 23 11/05/13 24 23 11/06/13 24 23 11/07/13 24 23 11/08/13 24 23 11/09/13 25 23 11/10/13 24 22 11/11/13 24 22 11/12/13 23 22 11/13/13 23 21 11/14/13 23 23 11/15/13 23 23 11/16/13 23 22 11/17/13 22 22 11/18/13 23 22 11/19/13 22 22 11/20/13 22 21

----------------------------------------------------------------------------------------------------------------------------------- GRAND MEAN 23 23 SD 0.8 0.8 CV(%) 3.48 3.48 N 38 38 MANUALv1.0 12/15/2013 R:02/07/2014 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Page 5 of 9**Page 208 of 1107**INHALATION TABLE 4

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN CHAMBER RELATIVE HUMIDITY [%]

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 0 PPM 10000 PPM DATE CHAMBER: 5A 5B

----------------------------------------------------------------------------------------------------------------------------------- 10/14/13 52 60 10/15/13 53 61 10/16/13 54 59 10/17/13 37 50 10/18/13 28 51 10/19/13 30 61 10/20/13 30 51 10/21/13 31 60 10/22/13 30 51 10/23/13 29 61 10/24/13 23 58 10/25/13 56 56 10/26/13 60 51 10/27/13 58 61 10/28/13 56 60 10/29/13 58 62 10/30/13 61 61 10/31/13 55 63 11/01/13 57 58 11/02/13 60 76 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Page 6 of 9**Page 209 of 1107**INHALATION TABLE 4

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN CHAMBER RELATIVE HUMIDITY [%]

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 0 PPM 10000 PPM DATE CHAMBER: 5A 5B

----------------------------------------------------------------------------------------------------------------------------------- 11/03/13 58 60 11/04/13 58 62 11/05/13 57 59 11/06/13 59 61 11/07/13 58 60 11/08/13 56 61 11/09/13 54 59 11/10/13 62 60 11/11/13 57 59 11/12/13 54 58 11/13/13 52 53 11/14/13 56 56 11/15/13 55 51 11/16/13 53 54 11/17/13 60 61 11/18/13 61 60 11/19/13 59 51 11/20/13 60 58

----------------------------------------------------------------------------------------------------------------------------------- GRAND MEAN 51 58 SD 11.6 4.9 CV(%) 22.75 8.45 N 38 38 MANUALv1.0 12/16/2013 R:02/07/2014 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Page 7 of 9**Page 210 of 1107**INHALATION TABLE 6

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN CHAMBER VENTILATION RATE [L/MIN]

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 0 PPM 10000 PPM DATE CHAMBER: 5A 5B

----------------------------------------------------------------------------------------------------------------------------------- 10/14/13 114 116 10/15/13 113 116 10/16/13 115 116 10/17/13 116 122 10/18/13 116 119 10/19/13 113 122 10/20/13 112 126 10/21/13 112 116 10/22/13 107 136 10/23/13 107 112 10/24/13 101 122 10/25/13 101 109 10/26/13 102 96 10/27/13 100 102 10/28/13 120 109 10/29/13 118 109 10/30/13 112 106 10/31/13 116 109 11/01/13 116 106 11/02/13 117 109 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Page 8 of 9**Page 211 of 1107**INHALATION TABLE 6

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN CHAMBER VENTILATION RATE [L/MIN]

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 0 PPM 10000 PPM DATE CHAMBER: 5A 5B

----------------------------------------------------------------------------------------------------------------------------------- 11/03/13 118 112 11/04/13 116 112 11/05/13 116 109 11/06/13 118 109 11/07/13 119 99 11/08/13 124 99 11/09/13 126 122 11/10/13 128 109 11/11/13 122 102 11/12/13 111 109 11/13/13 112 102 11/14/13 116 102 11/15/13 123 116 11/16/13 116 102 11/17/13 117 106 11/18/13 120 106 11/19/13 124 112 11/20/13 114 102

----------------------------------------------------------------------------------------------------------------------------------- GRAND MEAN 115 111 SD 6.7 8.5 CV(%) 5.83 7.66 N 38 38 MANUALv1.0 12/15/2013 R:02/07/2014 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Page 9 of 9**Page 212 of 1107**

## An Inhalation Reproduction/Developmental Toxicity Screening Study of 2

- Bromo

- 3,3,3

- Trifluoropropene in Rats

Exposure Atmosphere Generation Report

Date Issued

1 4 March 2014

WI L Research Inhalation Department WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 1 of 56

**Page 213 of 1107**

## WIL-65501 American Pacific Corporation

REPORT REVIEW AND 

## APPROVAL



# Report Approved 

## by: 

# fh==LR

Arthur 

## J. Stephens, BA Biologist, Inhalation Toxicology Lead Technician

Page 

## 2 of 56 

## Inhalation Report



## Page 214 of 1107

# L **IST OF** 

# A **BBREVIATIONS**



## The following abbreviations may apply to this report:

%RE

- percent rela tive error AL C

- approximate lethal

concentration btm

- bottom CNOS

- conventional nose

- onl y

sy stem

conc.

- concentration CP

- commercial product CVR

- chamber ventilation rate DI

- deionized ECD

- electron capture detection EtOH

- ethanol F

- fe male FID

- flame ionization detection GC

- gas chromatograph GSD

- geometric standard

deviation HEPA

- high efficiency particulate air HPL C

- high performance liquid

chromatograph y hr

- hour(s) IS

- internal standard LLOQ

- lower limit of quantitat ion L/min

- liters per minute LPM

- liters per minute M

- male MeOH

- methanol mg/m 3



## - milligram per meter cubed mid

- middle min

- minute MMAD

- mass median aerod yn amic

diameter N

- number NA

- not applicable ND

- not detected NOS

- nose

- only sy stem NQ

- not quantifiable NS

- no sample
ppm

- parts per million QC

- quality

control ref.

- reference RSD

- relative standard deviation SD

- standard deviation SE

- standard error

sec

- second ( s ) SL PM

- standard liters per minute SOP

- stand ard operating

procedure TCD

- thermal conductivity

detection theo.

- theoretical U H PL C

- ultra

- high performance

liquid chromatograph y ULOQ

- upper limit of quantitation UV

- ultraviolet

v

- volume

w

- weight WDF

- Wright Dust Feeder WI NH

- Inhalat ion Exposure Data

Collection Sy stem WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 3 of 56

**Page 215 of 1107**

# T **ABLE O F**  

# C **ONTENTS** 

## Page

**Report Review and Approval ................................**

**................................ ...............**  **2**

**List of Abbreviations**

**................................ ................................**  **............................. 3** 

**Table of Contents**

**................................ ................................**  **................................ ...**  **4 Index of Figures** 

**................................ ................................**  **................................ ......**  **5**

**Index of Tables**

**................................ ................................**  **................................ .......**  **5**

**1 . Introduction................................** 

**................................ ................................**  **............ 6** 

1.1

. WI L Research Key

Study Personnel

................................ ................................ ........ 6

1.2

. WI L R esearch Computer Sy stems

- Report Generation

................................ .......... 6

**2 . Exposure Methods ................................** 

**................................ ................................**  **. 7** 

2.1

. Exposure Regimen

................................ ................................ ................................ ... 7

2.2

. Inhalation Exposure Sy stem Description

................................ ................................ . 7

2.3

. Daily

Exposure Timing

................................ ................................ ............................ 8

2.4

. Animal Transport and Placement

................................ ................................ ............. 9

2.5

. Exposure Environmental Conditions

................................ ................................ ....... 9

**3 . Test Atmosphere Generation Methods ................................** 

**.............................. 11** 

3.1

. Exposure Chambers 2, 3, and 4

................................ ................................ ............. 11

3.2 . Exposure Chambers 5B (10,000 ppm)................................

................................ ... 12

**4 . Methods of Characterization of Exposure Atmospheres ................................** 

**. 14** 

4 .1

. Analy zed Exposure Concentrations

................................ ................................ ....... 14

4.1.1

. Analy

tical Methods

................................ ................................ ................................ 14

4.1.2 . Gas Chromatograph Calibration ................................

................................ ............ 16

4.1.3 . Calculation of Test Substance and Exposure Atmo sphere Concentrations

........... 17

4.1.4

. Determination of Homogeneity of Exposure Atmospheres

................................ ... 18

**5**

**. Results of Characterization of Actual Exposure Concentrations** 

**.................... 20** 

5.1

. Ex posure Concentrations

................................ ................................ ....................... 20 WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 4 of 56

**Page 216 of 1107**

# I **NDEX O F**  

# F **IGURES** 

## Page

1. Atmosphere Generation and Exposure Sy stem ( Chambers 2, 3, and 4)

............... . 2 2

2. Atmosphere Generation and Exposure Sy stem ( Chamber 5 B )

.............................. 23



# I **NDEX O F**  

# T **AB LES** 



## 1. Daily M ean Temper ature Values [° C ]

................................ ................................ ... 25

2. Daily Mean Chamber Temperature [ degrees C elsius ]

................................ ........... 27

3. Daily Mean Humidity Values [ % ]

................................ ................................ ........ . 29

4. Daily Mean Chamber Relative Humidity [ % ]

................................ ...................... . 31

5

. Daily Mea n CVR Values [ L/ min ]

................................ ................................ ......... . 33

6

. Daily Mea n Chamber Ventilation Rate [ L/ min ]

................................ .................... 35

7

. T est Atmosphere Homogeneity Determination

................................ ..................... 37

8

. Daily Mean Concentration Value s for 2

- Bromo

- 3,3,3

- Triflu (ppm)

.................... . 41

9

. Daily Mean Test Atmosphere Concentrations

................................ ....................... 49 WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 5 of 56

**Page 217 of 1107**

# 1. **I NTRODUCTION** 



## This report presents the inhalation study d esign, exposure atmosphere genera tion, and anal ys is
methods used during the conduct of this study

.



# 1.1. **WIL R**  **ESEARCH** 

# K **EY** 

# S **TUDY** 

# P **ERSONNEL** 

## Arthur J. Stephens , B A Biologist , Inhalation Toxicology Christine A. Heston, BA Quality Control Coordinator , Inhalation Toxicology Ja son M. Sny

der, B S Group Supervisor , Inhalation Toxicology Daniel T. Kirkpatrick, PhD, DABT Director, Inhalation Toxicology Andrew J. Smith, BS Group Manager, Inhalation Toxicology Sarah E. Brockway , BS Data Coordinator

, Reporting & Technical Support Services Gregory A. Hawks, AS Group Supervisor, Reporting & Technical Support Services Robert A. Wally , BS Operations Manager, Reporting & Technical Support Services



# 1.2. **WIL R**  **ESEARCH** 

# C **OMPUTER** 

# S **YSTEMS**



# - **R EPORT**  

# G **ENERATION**
Program/System Description Archive Man agement System (AMS) In

- house developed application for storage, maintenance, and retrieval of information for archived materials ( e.g. , lab books, study data, wet tissues, slides, etc. )

. InSi ght ® 

## Publisher Electronic publishing system (output is Adobe Ac robat, PDF)

. Master Schedule Maintains the m aster schedule for the company. Metasys DDC Electronic Environmental Control System Controls and monitors animal room environmental conditions.

Microsoft ® 

## Office 2007 Used in conjunction with the publishing so ftware to generate study reports. WIL Toxicology Data Management SystemTM (WTDMSTM) In

- house developed system used for collection and reporting of in

- life and postmortem data.
Note: Version numbers of WTDMSTM programs used for the study are presented on th e report data tables (reporting programs); version numbers and release dates are otherwise maintained in the study records and/or facility records. 

## WIL

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- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 6 of 56

**Page 218 of 1107**

# 2. **E XPOSURE**  

# M **ETHODS**



# 2.1. **E XPOSURE**  

# R **EGIMEN**



## The test substance, 2

- bromo

- 3,3,3

- t rifluoropropene or filtered air (co ntrol group) were
administered as dail y 6

- hour whole

- body inhalation exposure s for Groups 1, 2, 3, and 4

. The test

substance was administered as a daily 5

- minute whole body

e xposure for Group 5

. A d etailed
description of the study

d esign and exposure sch edule is presented in the main report. Table T1
presents the overall schedule for inhalation exposures:

**Table T1. Exposure Schedule** 
Study Day Date
First Exposure 0 14 October 2013
Last Exposure 51 04 December 2013



# 2.2. **I NHALA** 

**TION** 

# E **XPOSURE** 

# S **YST EM**  

# D **ESCRIPTION** 

## Exposures were conducted in four 1.0

- m 3 

## stainless steel and glass for Groups 1, 2, 3, and 4 and

two 0.5

- m 3 

## stainless steel and gl ass whole

- body inhalation chambers for Group 5

. Group 5

exposure animals were exposed to filtered air (Chamber 5A) prior to a dail y 5

- minute test

substance exposure (Chamber 5B). F ollowing the 5

- minute exposure, animals were returned to

Chamber 5A for the duration of the 6

- hour exposure period

. Chambers were dedicated for the

group s as shown in Table T2

.

**Table T2. Study De**  **sign**

Group: 1 2 3 4 5 5

Exposure Chamber : 1 2 3 4 5 A 5 B Target Exposure Concentration ( ppm ): 0 50 100 175 0 10,00 0

Chamber suppl y air was provided from a HEPA

- and charcoal

- filtered, temperature

- and
humidity

- co ntrolled source. T reatment of exhaust air consisted of charcoal

- and

HEPA

- filtration. WIL

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# 2.3. **D AILY**  

# E **XP OSURE**  

# T **IMING**



## For the 6

- hour test substance exposures (Chambers 2, 3, and 4), exposures were initiated when

the generation sy stem’s 3

- way v alve, which directed test substance vapor, was switched from
“By pass” to “Exposure” and ended after the valve had been in the “Exposure” position for

6

- hours and was switched back to “By pass” ( see Section 3)

.

The 5

- minute 10,000 ppm group exposures were performed as follows ( see schematic below). A

pre

- generation with concentration anal ys is was performed to insure that the exposure
concentration was appropriately t argeted. W hen successful pre

- generation was achieved, the

cage batteries with animals were transferred to Cham ber 5B (test substance), which was then

resealed (T = 0 minutes). S ince the concentration dropped rapidly d uring this transfer, a

4

- minute concentration build

- up period was allowed in order to re

- establish a suitable vapor concentration near 10,000 ppm. At T = 4 minutes, a GC sample was collected from Chamber 5B

and the exposure was started. A t the end of the 5

- minute exposure period (T = 9 minutes), a
second GC sample was collected and the batteries with animals were transferred back to

Chamber 5A (fil tered air) for the duration of the 6

- hour exposure. A ll transfers into and out of

Chamber 5B were performed by t echnicians equipped with appropriate personal protective
equipment. WIL

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- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 8 of 56

**Page 220 of 1107**

# 2.4. **A NIMAL**  

# T **RANSPOR T**  **A ND**  

# P **LACEMENT**



## Animals were housed in a normal animal c olony r oom during non

- exposure hours. For each

exposure, the animals were transferred to rat exposure caging, tra nsported to Exposure Room 3 (Groups 1, 2, 3, and 4) and Exposure Room 5 (G roup 5)

, exposed for the requisite duration, and

returned to their h ome cages in the animal colony room. A nimals were individually h oused in

stainless steel wire

- mesh caging during the exposures . F ood and water were withheld during the
animal exposure period.



# 2.5. **E XPOSURE**  

# E **NVIRONMENT AL**  

# C **ONDITIONS**



## For Chamber s 1, 2, 3, and 4, temperatur e , relative humidity

, and chamber ventilation rate were continually

m onitored and recorded at least hourly during exposure through the use of the

Inhalation Exposure Data Collection Sy stem (WI NH) and a personal computer. Chamber

temperature and relative humidity were monitored using an Omega ® 

## temperature and relati ve humidity t ransmitter probe (model n o. HX94C, Omega E ngineering, In c., Stamford, CT)

. T emperatur e, relative humidity

, and chamber ventilation rate were continually m onitored and

man ually recorded once during the 5

- minute exposure period for Chamber 5B and at least hourl y
for Chamber 5A during the exposure

. Chamber temperatur e and relative humidity were
monitored using an Omega ® 

## temperature and relati ve humidity t ransmitter probe (mo del

n o. HX94C, Omega E ngineering, Inc., Stamford, CT) and display b ox. The daily

m ean temperature and mean rela tive humidity were to be 19 ° C to 25 ° C and 30% to 70 %, respectively

.

Chambers were operated under dy namic conditions with at least 12 to 15 air changes per hour at

a slight negative pressure. Chamber airflow was monitored using a sharp edge orifice meter and
Dwy er Magnehelic ® 

## Indicating Transmitter pressure gauge (Dw ye r Instruments, In c., Michigan
City

, IN). E ach gauge was calibrated for conver sion from pressure to airflow in standard liters

per minute through the use of a Fox Gas Mass Flowmeter Transmitter (Model FT2, Fox Thermal
Instruments, Marina, CA). Chamber negative pressure was m onitored using a Dwy er Magnehelic ® 

## Indicating Transmitter pressure gauge (Dwy er Instruments, Inc., Michigan City

, IN ). Dail y means for chamber temperature, re lative humidity , and ventilation rate over the study WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 9 of 56

**Page 221 of 1107**

## period are pr esented in Table 1, Table 2, Table 3

, Table 4, Table 5

, and Table 6 of this appendix.

T a ble T3 summarizes the mean e nvironmental conditions for all chambers:

**Table T3. Mean Environmental**  **Conditions**

Exposure Chamber : 1 2 3 4 5A 5B
Temperature ( ° C ): 23 22 22 23 2 3 2 3

Standard Deviation: 0.7 0.8 0.6 0.7 0.8 0.8

R elative Humidity

(%): 59 52 55 54 51 5 8

Standard Deviation: 2.4 3.0 4.0 4.9 11.6 4.9

Ventilation Rate (L PM): 221 222 223 221 11 5 11 1

Standard Deviation: 6.8 6.7 6.4 5.8 6. 7 8. 5

N : 38 39 40 52 38 38

O xy gen conte nt of the exposure atmospheres was determined during the method development
phase using a Dräger PAC III calibrated oxy gen sensor (serial no. ERRH

- 0148, Draeger Safet y

In c., Pittsburgh, PA). The ox ygen content for all chambers was at least 19.0 %. WIL

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- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 10 of 56

**Page 222 of 1107**

# 3. **T EST**  

# A **TMOSPHERE** 

# G **ENERA TION**  

# M **ETHODS**


# 3.1. **E XPOSURE**  

# C **HAMBERS** 

# 2, **3, AND**  

# 4

A single vapor generator was used to produce a vapor and a distribution sy stem was used to

deliver a controlled amount of test substance to each chamber as shown in Figure 1

. T he single

generator consisted of a sealable 4

- neck reaction flask (1000 mL ) that was filled with an

appro priate volume of test substance and heated to 29 ° C to 41 ° C using a mantle

- ty pe heater
(Glas

- Col, LLC, Terre Haute, IN) controlled using a Powerstat variable transformer (m odel

no. 3PN116C, Superior Electric, Farmington, CT). Using a regulator (Coilhose Pneumatics , Inc.,

East Brunswick, NJ) and an Omega ® 

## digital mass flowmeter (model no

. FMA182 0 )

, compressed

n itrogen was metered to 1 port of the reaction flask

. Two ports w ere used to measure both the
liquid and vapor temperatures separatel y within the flask

. T he temperatures were monitored
using separate probe s and Omega ® 

## PI D temperature controller s and process monitor s (model

no. CNi1654). The outlet port was used to del iver test substance vapor to a stainless steel
mixing

- tee through a 3

- way v alve (b ypass valve)

. With the 3

- way v alve in the “EXPOSURE”
position, test substance vapor was directed to the mixing tee where dilution air was add ed

. Using

a C oilhose regulator (model no. 8802K) and an Omega ® 

## digital mass flowmeter (model

no

. FMA 1820)

, compressed air was added to the mixing tee. The test substance atmosphere was
directed from the mixing tee to a stainless steel manifold where it was distributed to each

exposure chamber using compressed air

- powered, adjustable transvector air pumps

. T able T4

summarizes the generation parameters for exposure:

**Table T4. Generation Parameters** 

Nitrogen F low Rate Dilution Airflow Rate (Indicated) (L PM)

0.14

- 0.80 10

- 12

The vapor generator, distribution manifold, bypass valve and interconnecting Teflon ® 

## or
stainless steel tubing, and fittings were contained within a vented safety c abinet. T he air exiting

the cabinet w as connected to the facility exhaust. WIL

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- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 11 of 56

**Page 223 of 1107**

## Using Coilhose regulator s (model no. 8802K), compressed air was supplied to each transvector

(VDF

- 100, Vaccon Company

, In c., Medway

, MA) to control the portion of test substance
atmosphere pulled fro m the manifold. A metal orifice (O’Keefe Controls Co., Trumbull, CT)

w as placed i n

- line after the manifold to restrict the flow directed to each transvector. T est

substance atmosphere was delivered to each chamber inlet via 3 

## / 8 

## - inch pol yeth yl ene line s

. Chamber supply

a ir was added to the chamber inlet where it mixed with the test sub stance atmosphere to produce the desired exposure concentration prior to entering the chamber

. T able T5 summarizes the transvector parameters settings for each test substance chamber:

**Table T5. Transvector Parameters** 

Chamber Orifice no. Transvector Setting ( psi)

2 35 10.5

- 14.0

3 63 6.5

- 12.0

4 73 10.0

- 16.0



# 3.2. **E XPOSURE**  

# C **HAMBERS** 

# 5B **(10,000 PPM**  

# )

A single vapor generator was used to produce a vapor atmosphere as shown in Figure 2

. A

500

- mL gas washing bottle

, filled with an initial appropria te amount of test sub stance, was
heated in an oil bath

. T he oil bath (Fisher Scientific Isotemp [model no. 102, Fisher Scientific,
Waltham, MA]) was heated to between 63 ° C and 86 ° C monitored with a J

- Ty pe thermocouple,

and controlled using an Omega ® 

## PI D t emperature controller and process monitor (model

no. CNi1654) (read

- out only )

. Using an FM I Lab pump (model no. QG 20, Fluid Metering, Inc.,
Sy osset, NY)

, additional test substance was delivered at a constant rate from the reservoir to the

gas washing bot tle. Using a Coilhose Pneumatics regulator (model no. 8802K) and a

rotameter

- ty

pe flowmeter (model no. PMR1

- 010649, Cole

- Parmer, Vernon Hills, IL),
compressed nitrogen was metered through a tube heate r to the inlet of the gas washing bottle.

The tube he ater was heated to 89°C to 114°C, monitored using a J

- Typ e thermocouple

, and

controlled using an Omega ® 

## PI D temperature controller and process monitor (model WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 12 of 56

**Page 224 of 1107**

## no. CNi1654). Nitrogen was metered into the inlet stem of the gas washing bottle where it

passed through a fritted disk and bubbled through the liquid test substance to produce vapors of

the test substance

. Test substance vapor from the gas washing bottle was delivered to the

chamber inlet via 1⁄4

- inch poly eth yl ene line. C hamber supply a ir was added t o the chamber inlet

where it mixed w ith the test substance vapor to produce the desired exposure concentration prior

to entering the chamber. T he vapor generator and test atmosphere exposure chamber was
contained within a vented hood

. T able T6 summarizes the generation parameters:

**Table T6. Generation Parameters** 

Nitrogen Flow Rate Test Substance Delivery Rate (L PM) (mL / m in ute )

8.9

- 13 5.2

- 7.6 WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 13 of 56

**Page 225 of 1107**

# 4. **M ETHODS O**  **F** 

# C **HARACTERIZA TION**  **OF** 

# E **XPOSURE** 

# A **TMOSPHERES**


# 4.1. **A NALYZED**  

# E **XPOSURE** 

# C **ONCENTRATIONS**


# 4.1.1. **A NALYTICAL**  

# M **ETHOD S** 



## Ana ly zed exposure concentrations were determined at approximately 60

- minute intervals using a

GC. S amples were collected from the approximate animal

- breathing zone of the inhalation

exposure chambers via 1⁄8

- inch stainless steel tubing

. For Chambers 1, 2, 3, and 4, samples were
collected under the control of the WI NH data acquisition software application and sampling and

anal ys es were performed as follows. T he program control led an external multi

- position valve
(Model E16, Valco Instruments Co., In c., Houston, TX) that permits sequential sampling from

the exposure room and each exposure chamber. G as sample injection onto the chromatograph y
column occurred via an internal gas

- sampling valve with sample loop ; the chromatograph wa s display ed and the area under the sample peak wa s calculated and stored. T he WINH program
then acquired the stored peak area data and used an ln

- quadratic equation based on the GC

calibration curve to calculate the measured concentr atio ns in parts per million (ppm). The
following table summarize s the operational parameters used for the GC methods for Chambers 1,
2, 3, and 4

.
**Equipment**

GC : Hewlett Packard 5890 Series II

GC Detector: FID

GC Column: Agilent DB

- 5 30 m × 0.5 30 mm I D, 1.5

- micron film

- thickness
Integrator: Agilent Model 3396 Series II

**GC Gases** Pressure Approximate Flow Rate (psig) (mL /minute)

Carrier

- Helium: 20 10 ± 1

Fuel

- Hy drogen: 15 32 ± 3

Air: 30 290 ± 10 WIL

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- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 14 of 56

**Page 226 of 1107**

## GC Temperatures **( °**  **C)**

Column: 25

Detector: 350
**Integrator Run Parameters**

Chart Zero Offset: 0

Chart Attenuation: 3
Chart Speed: 1.0 cm/minute
Peak Area Rejection Value: 0

Peak Threshold: 4

Peak Width: 0.05

Retentio n Time: Approximately 1.7 minutes

For Chambers 5A and 5B, analy tical samples were manually c ollected approximately

hourly a nd

twice during the test substance exposure, respectively

, using an external multi

- position valve
(Model E16, Valco Instruments Co.

, In c., Houston, TX) that permits sequential sampling from

the exposure room and each exposure chamber. G as sample injection onto the chromatograph y
column occurred via an internal gas

- sampling valve with sample loop, the chromatograph wa s display ed and t he area under the sample peak wa s calculated and stored. The ln

- quadratic
equation based on the GC calibration curve was used to calculate the measured concentratio ns in
parts per million (ppm). The following table summarize s the operational parameters u sed for the

GC methods for Chambers 5A and 5B

.
**Equipment**

GC : Hewlett Packard 5890 Series II

GC Detector: F ID

GC Column: Agilent DB

- 5 30 m × 0.530 mm I D, 1.5

- micron film

- thickness
Integrator: Agilent Model 3396 Series II WIL

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- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 15 of 56

**Page 227 of 1107**

## GC **Gases** Pressure Approximate Flow Rate (psig) (mL /minute)

Carrier

- Helium: 27.5 10 ± 1

Fuel

- Hy drogen: 30 32 ± 3

Air: 32.5 290 ± 10

**GC Temperatures**  **( °**  **C)**

Column: 25

Detector: 350
**Integrator Run Parameters** 

Chart Ze ro Offset: 0

Chart Attenuation: 10
Chart Speed: 1.0 cm/minute
Peak Area Rejection Value: 0

Peak Threshold: 6

Peak Width: 0.05

Retention Time: Approximately 1.6 minutes



# 4.1.2. **G AS**  

# C **HROMATOGRAPH** 

# C **ALIBRATION**



## The GC was calibrated using g as

- phase standards prepared to contain a known vapor
concentration of the test substance in 10

- L or 25

- L Tedlar ® 

## gas bags (SKC, In c., Eighty F our, PA). S tandard s were prepared by i njecting a known volume of liquid test substance into the

standard bag fill ed with the appropriate amount of compressed air

. A dry t est meter (DTM

- 200A, Elster American Meter Co., Nebraska City

, NE) was used to measure the total

volume of air. The standard bag was manually a gitated prior to sampling and then placed on the

appro priate valve position and sampled for 2 minutes prior to being anal yz ed by t he GC.
Concentrations of the gas

- phase standards were calculated as follows : WIL

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- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 16 of 56

**Page 228 of 1107**

## Concentration (ppm) = WT × MV × 10 6


## GMW × VOL × DEN Where:

WT = Injection volume from basis bag , mL

MV = Molar volume at 730 mmHg and 21oC, 25.11 L /mol

10 6



## = ppm conversion factor

GMW Gram molecular weight, 174.950 g/mol

VOL Volume of air injected into standard bag, L

DEN Density

, 1.686 g/mL



# 4.1.3. **C ALCULATION OF**  

# T **EST** 

# S **UBSTANC E AND**  

# E **XPOSURE** 

# A **TMOSPHERE** 

# C **ONCENTRATIONS**



## The GC was calibrated with standards prepared and anal yz ed in triplicate. One calibration curve

was prepared for Chambers 1, 2, 3, and 4 using 4 vapor concentrations spanning an appropriate

range relative to th e ta rget exposure concentration

. A second calibration curve was prepared for

Chambers 5A and 5B using 3 vapor concentrations spanning an appropriate range relative to th e
target exposure concentration

. T he peak area (y ) and the theoretical concentrations (x) of the

calibration standards were fit with least

- squares regression anal ys is to the ln

- quadratic function:

ln (y ) = a × [ln (x)] 2 

## + b × ln (x) + c

Prior to the initiation of the exposure, at least 1 standard was prepared and analy zed to perform a

calibra tion check of the GC. The GC was considered to be in calibration if the analy zed

concentration of the prepared standard was within ± 10% of the known concentration

. T able T7 lists the standards used for the Chamber 1, 2, 3, and 4 calibration curve (A) an d Chamber 5A and
5B calibration curve (B): WIL

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- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 17 of 56

**Page 229 of 1107**

## Table T7. **Calibration Curve Standards**

Calibration Curve Standard Concentration Test Substance Volume Dilution Air Volume (ppm) ( μL ) (L)

A 36 3 20

A 48 4 20

A 121 10 20

A 254 21 20

B 4,992 165 8

B 9,984 330 8

B 15,127 500 8



# 4.1.4. **D ETERMINATION OF**  

# H **OMOGENEITY OF** 

# E **XPOSURE** 

# A **TMOSPHERES**



## Hom ogeneity

of exposure concentrations was evaluated d uring the method development phase of

the study

. Two or 4 test locations and a reference location were used for these determinations.
Samples were collected and anal yz ed on the GC as rapidly a s possible by alternating from the

reference location and then to a test location. H omogeneity w as performed in triplicate for each

test substance exposure chamber. T he measured concentration was calculated as a percent

difference for each position from the reference location. The results of homogeneit y
determinat ion are presented in Table 7 of this appendix. T able T8 summarizes the mean data of
the replicates for the test substance chambers : WIL

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- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 18 of 56

**Page 230 of 1107**

## Table T8. **Mean Homo**  **geneity Determinations** 

Exposure Sy stem Test L ocation Mean % f rom Reference

2 Upper Front

- 2.7

Lower Front

- 1.3
Upper Rear

- 1.4

Lower Rear

- 2.8

3 Upper Front 0.3

Lower Front

- 0.7
Upper Rear

- 2.1

Lower Rear

- 1.0

4 Upper Front

- 0.4

Lower Front

- 1.2
Upper Rear

- 1.7

Lower Rear

- 1.7

5B Upper Front 1.0

Lower Rear 1.7 WIL

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**Page 231 of 1107**

# 5. **R ESUL**  **TS OF**  

# C **HARACTERIZA TION OF**  

# A **CTUAL** 

# E **XPOSURE** 

# C **ONCENTRA TIONS** 


# 5.1. **E XPOSURE**  

# C **ONCENTRATIONS**



## The anal yz ed concentrations for each chamber are presented in Table 8 and Table 9 of this
appendix. T able T9 summarizes the o verall mean anal yz ed concentrations of each chamber:

**Table T9. Overall**  **Mean Exposure Concentrations** 

Exposure Chamber: 1 2 3 4 5A 5B *
Target Concentration ( ppm ): 0 50 100 175 0 10,000

Mean Concentration ( ppm ): 0 50 101 174 0 10,076

Standard Deviation: 0.0 3.2 4.8 10.7 0.0 607.9

N : 38 39 40 52 38 38

* = Mean obtained from T=4 minutes and T=9 minutes. See Section 2.3 for clarification. WIL

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- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 20 of 56

**Page 232 of 1107**

# F IGURES



## W I L

- 65501 2

- B romo

- 3,3,3

- Tr ifluoro pr ope ne Ame ric a n P a c ific Cor

por a ti on

- - I nh a lation R e port

Page 21 of 56

**Page 233 of 1107**

## Figure 1. Atmosphere Generation a nd Exposure System (Chambers 2, 3, and 4)

WIL

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- - Inhalation Report Page 22 of 56

**Page 234 of 1107**

## Figure 2. Atmosphere Generation and Exposure System (Chamber 5B)

WIL

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- - Inhalation Report Page 23 of 56

**Page 235 of 1107**

# T ABLES a a a a a



## WIL

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- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 24 of 56

**Page 236 of 1107**PROJECT NO.:WIL-65501 PAGE 1 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE INHALATION TABLE 1

----------------------------------------------------------------------------------------------------------------------------------- DAILY MEAN TEMPERATURE VALUES (°C)

RUN DATE 0 PPM 50 PPM 100 PPM 175 PPM

------------------------------------------------------------------------------------------------------------------------------------

22.9 21.9 23.0 23.1 14-OCT-2013

22.0 21.0 21.8 21.8 15-OCT-2013

22.9 21.7 22.1 22.5 16-OCT-2013

23.1 22.0 23.0 23.0 17-OCT-2013

21.8 20.8 21.5 21.7 18-OCT-2013

23.0 21.7 22.2 22.4 19-OCT-2013

22.9 21.9 23.0 22.9 20-OCT-2013

22.4 21.5 21.9 22.4 21-OCT-2013

23.1 21.9 22.1 22.5 22-OCT-2013

23.3 22.2 23.3 23.3 23-OCT-2013

22.3 21.2 21.7 21.8 24-OCT-2013

23.2 21.8 22.1 22.4 25-OCT-2013

23.5 22.4 23.3 23.2 26-OCT-2013

22.5 21.3 21.9 21.9 27-OCT-2013

23.3 22.0 22.3 22.6 28-OCT-2013

23.3 22.3 23.3 23.2 29-OCT-2013

22.4 21.1 21.2 21.7 30-OCT-2013

23.2 21.9 22.2 22.6 31-OCT-2013

23.6 22.3 23.3 23.6 01-NOV-2013

22.9 21.7 22.3 22.5 02-NOV-2013

23.7 22.1 22.5 23.0 03-NOV-2013

23.7 22.4 23.3 23.4 04-NOV-2013

22.9 21.6 22.7 22.4 05-NOV-2013

23.4 22.1 22.3 23.0 06-NOV-2013

23.8 22.8 23.6 24.1 07-NOV-2013

22.9 21.7 22.1 22.4 08-NOV-2013

23.7 22.7 22.6 23.3 09-NOV-2013

23.9 22.9 23.8 24.1 10-NOV-2013

WIL Research Laboratories, LLC Report File: TemperatureSummary v1.09.rpt (04-10-13), WINH version 1.24 Printed On: 17-Dec-2013 15:16 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 25 of 56**Page 237 of 1107**PROJECT NO.:WIL-65501 PAGE 2 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE INHALATION TABLE 1

----------------------------------------------------------------------------------------------------------------------------------- DAILY MEAN TEMPERATURE VALUES (°C)

RUN DATE 0 PPM 50 PPM 100 PPM 175 PPM

------------------------------------------------------------------------------------------------------------------------------------

22.2 21.2 21.4 22.0 11-NOV-2013

23.4 22.3 22.3 22.9 12-NOV-2013

22.1 21.0 21.0 21.2 13-NOV-2013

21.8 20.7 20.8 21.2 14-NOV-2013

23.5 22.2 22.1 22.5 15-NOV-2013

22.2 21.3 21.5 21.9 16-NOV-2013

22.3 21.2 21.4 21.8 17-NOV-2013

23.7 22.3 22.4 23.0 18-NOV-2013

22.4 21.2 21.4 21.8 19-NOV-2013

21.8 20.7 20.7 21.2 20-NOV-2013

22.5 21.2 21.5 NA 21-NOV-2013

22.2 21.1 NA NA 22-NOV-2013

22.2 NA NA NA 23-NOV-2013

22.7 NA NA NA 24-NOV-2013

22.6 NA NA NA 25-NOV-2013

22.3 NA NA NA 26-NOV-2013

22.7 NA NA NA 27-NOV-2013

22.6 NA NA NA 28-NOV-2013

22.3 NA NA NA 29-NOV-2013

23.6 NA NA NA 30-NOV-2013

21.1 NA NA NA 01-DEC-2013

21.4 NA NA NA 02-DEC-2013

21.5 NA NA NA 03-DEC-2013

21.3 NA NA NA 04-DEC-2013

22.5 GRAND MEAN: 22.2 21.7 22.7
SD:
N: 0.74 0.79 0.59 0.71 38 39 40 52

WIL Research Laboratories, LLC Report File: TemperatureSummary v1.09.rpt (04-10-13), WINH version 1.24 Printed On: 17-Dec-2013 15:16 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 26 of 56**Page 238 of 1107**INHALATION TABLE 2

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN CHAMBER TEMPERATURE [DEGREES CELSIUS]

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 0 PPM 10000 PPM DATE CHAMBER: 5A 5B

----------------------------------------------------------------------------------------------------------------------------------- 10/14/13 23 22 10/15/13 23 21 10/16/13 23 23 10/17/13 25 25 10/18/13 23 28 10/19/13 23 22 10/20/13 22 22 10/21/13 23 23 10/22/13 23 22 10/23/13 23 23 10/24/13 25 23 10/25/13 24 23 10/26/13 24 22 10/27/13 24 23 10/28/13 23 23 10/29/13 23 23 10/30/13 23 23 10/31/13 23 24 11/01/13 24 23 11/02/13 24 22 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 27 of 56**Page 239 of 1107**INHALATION TABLE 2

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN CHAMBER TEMPERATURE [DEGREES CELSIUS]

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 0 PPM 10000 PPM DATE CHAMBER: 5A 5B

----------------------------------------------------------------------------------------------------------------------------------- 11/03/13 24 23 11/04/13 24 23 11/05/13 24 23 11/06/13 24 23 11/07/13 24 23 11/08/13 24 23 11/09/13 25 23 11/10/13 24 22 11/11/13 24 22 11/12/13 23 22 11/13/13 23 21 11/14/13 23 23 11/15/13 23 23 11/16/13 23 22 11/17/13 22 22 11/18/13 23 22 11/19/13 22 22 11/20/13 22 21

----------------------------------------------------------------------------------------------------------------------------------- GRAND MEAN 23 23 SD 0.8 1.2 CV(%) 3.48 5.22 N 38 38 MANUALv1.0 12/15/2013 R:12/16/2013 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 28 of 56**Page 240 of 1107**INHALATION TABLE 3 PROJECT NO.:WIL-65501 PAGE 1 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE

----------------------------------------------------------------------------------------------------------------------------------- DAILY MEAN HUMIDITY VALUES (%)

RUN DATE 0 PPM 50 PPM 100 PPM 175 PPM

-----------------------------------------------------------------------------------------------------------------------------------
53.8 53.3 48.0 63.8 14-OCT-2013

52.1 56.6 51.2 60.0 15-OCT-2013

52.0 54.5 49.8 58.4 16-OCT-2013

51.9 54.7 48.2 59.2 17-OCT-2013

52.3 56.8 51.5 60.3 18-OCT-2013

54.9 56.9 52.9 57.8 19-OCT-2013

50.3 52.5 45.9 56.4 20-OCT-2013

51.9 55.6 51.4 58.8 21-OCT-2013

52.7 53.9 51.7 55.6 22-OCT-2013

53.9 53.6 47.6 58.0 23-OCT-2013

52.0 53.2 50.3 57.0 24-OCT-2013

54.2 55.6 52.1 57.2 25-OCT-2013

52.8 53.7 48.5 57.7 26-OCT-2013

53.6 56.2 51.9 59.1 27-OCT-2013

53.0 54.9 50.4 56.2 28-OCT-2013

54.4 54.3 49.1 59.1 29-OCT-2013

60.9 53.1 56.8 63.6 30-OCT-2013

55.1 53.2 52.3 58.5 31-OCT-2013

55.1 43.3 48.4 57.3 01-NOV-2013

55.4 45.2 53.0 58.7 02-NOV-2013

53.8 41.4 52.7 55.7 03-NOV-2013

53.1 53.4 49.0 57.8 04-NOV-2013

55.4 55.6 53.6 58.8 05-NOV-2013

59.4 58.9 54.1 60.2 06-NOV-2013

55.2 53.5 48.6 58.4 07-NOV-2013

52.4 54.7 51.5 55.9 08-NOV-2013

52.6 54.2 50.9 55.4 09-NOV-2013

53.6 53.6 48.2 56.3 10-NOV-2013

55.2 56.4 52.6 57.8 11-NOV-2013

WIL Research Laboratories, LLC Report File: HumiditySummary v1.09.rpt (04-10-13), WINH version 1.24 Printed On: 17-Dec-2013 15:16 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 29 of 56**Page 241 of 1107**INHALATION TABLE 3 PROJECT NO.:WIL-65501 PAGE 2 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE

----------------------------------------------------------------------------------------------------------------------------------- DAILY MEAN HUMIDITY VALUES (%)

RUN DATE 0 PPM 50 PPM 100 PPM 175 PPM

----------------------------------------------------------------------------------------------------------------------------------- 53.0 54.6 50.8 56.0 12-NOV-2013

58.0 57.6 57.3 63.0 13-NOV-2013

59.3 59.4 57.1 61.6 14-NOV-2013

56.4 56.0 51.9 59.8 15-NOV-2013

56.7 56.7 53.6 59.0 16-NOV-2013

55.0 56.8 53.6 59.5 17-NOV-2013

56.6 57.1 53.4 59.5 18-NOV-2013

56.0 58.5 54.7 60.4 19-NOV-2013

62.7 62.8 60.3 65.6 20-NOV-2013

65.7 58.5 53.2 NA 21-NOV-2013

58.8 58.6 NA NA 22-NOV-2013

29.1 NA NA NA 23-NOV-2013

47.9 NA NA NA 24-NOV-2013

50.6 NA NA NA 25-NOV-2013

53.6 NA NA NA 26-NOV-2013

51.0 NA NA NA 27-NOV-2013

52.2 NA NA NA 28-NOV-2013

53.6 NA NA NA 29-NOV-2013

50.7 NA NA NA 30-NOV-2013

58.5 NA NA NA 01-DEC-2013

57.5 NA NA NA 02-DEC-2013

58.9 NA NA NA 03-DEC-2013

60.0 NA NA NA 04-DEC-2013

N: GRAND MEAN: 58.8 51.7 54.7 54.3
SD: CV (%): 2.38 2.99 3.96 4.89

38 39 40 52 4.048 5.783 7.239 9.006

WIL Research Laboratories, LLC Report File: HumiditySummary v1.09.rpt (04-10-13), WINH version 1.24 Printed On: 17-Dec-2013 15:16 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 30 of 56**Page 242 of 1107**INHALATION TABLE 4

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN CHAMBER RELATIVE HUMIDITY [%]

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 0 PPM 10000 PPM DATE CHAMBER: 5A 5B

----------------------------------------------------------------------------------------------------------------------------------- 10/14/13 52 60 10/15/13 53 56 10/16/13 54 59 10/17/13 37 50 10/18/13 28 51 10/19/13 30 61 10/20/13 30 51 10/21/13 31 60 10/22/13 30 51 10/23/13 29 61 10/24/13 23 58 10/25/13 56 56 10/26/13 60 51 10/27/13 58 61 10/28/13 56 60 10/29/13 58 62 10/30/13 61 61 10/31/13 55 63 11/01/13 57 58 11/02/13 60 76 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 31 of 56**Page 243 of 1107**INHALATION TABLE 4

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN CHAMBER RELATIVE HUMIDITY [%]

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 0 PPM 10000 PPM DATE CHAMBER: 5A 5B

----------------------------------------------------------------------------------------------------------------------------------- 11/03/13 58 60 11/04/13 58 62 11/05/13 57 59 11/06/13 59 61 11/07/13 58 60 11/08/13 56 61 11/09/13 54 59 11/10/13 62 60 11/11/13 57 59 11/12/13 54 58 11/13/13 52 53 11/14/13 56 56 11/15/13 55 51 11/16/13 53 54 11/17/13 60 61 11/18/13 61 60 11/19/13 59 51 11/20/13 60 58

----------------------------------------------------------------------------------------------------------------------------------- GRAND MEAN 51 58 SD 011.6 14.9 CV(%) 22.75 8.45 N 38 38 MANUALv1.0 12/16/2013 R:12/16/2013 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 32 of 56**Page 244 of 1107**PROJECT NO.:WIL-65501 PAGE 1 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE INHALATION TABLE 5

----------------------------------------------------------------------------------------------------------------------------------- DAILY MEAN CVR VALUES (L/MIN)

RUN DATE 0 PPM 50 PPM 100 PPM 175 PPM

----------------------------------------------------------------------------------------------------------------------------------- 224 222 227 212 14-OCT-2013

223 222 226 211 15-OCT-2013

222 223 226 212 16-OCT-2013

221 223 227 213 17-OCT-2013

219 223 227 212 18-OCT-2013

213 236 226 215 19-OCT-2013

219 228 225 217 20-OCT-2013

221 224 221 211 21-OCT-2013

219 225 213 216 22-OCT-2013

221 215 210 218 23-OCT-2013

218 234 211 211 24-OCT-2013

227 227 227 225 25-OCT-2013

222 219 219 230 26-OCT-2013

219 221 218 227 27-OCT-2013

222 229 222 224 28-OCT-2013

215 235 229 225 29-OCT-2013

224 224 222 215 30-OCT-2013

217 223 223 214 31-OCT-2013

226 226 225 218 01-NOV-2013

219 230 228 222 02-NOV-2013

224 236 227 226 03-NOV-2013

232 228 222 226 04-NOV-2013

224 221 215 220 05-NOV-2013

223 220 224 218 06-NOV-2013

225 220 226 220 07-NOV-2013

231 229 235 229 08-NOV-2013

232 234 240 234 09-NOV-2013

233 226 222 233 10-NOV-2013

233 221 220 228 11-NOV-2013

WIL Research Laboratories, LLC Report File: CVRSummary v1.07.rpt (06-06-12), WINH version 1.24 Printed On: 18-Dec-2013 8:25 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 33 of 56**Page 245 of 1107**PROJECT NO.:WIL-65501 PAGE 2 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE INHALATION TABLE 5

----------------------------------------------------------------------------------------------------------------------------------- DAILY MEAN CVR VALUES (L/MIN)

RUN DATE 0 PPM 50 PPM 100 PPM 175 PPM

----------------------------------------------------------------------------------------------------------------------------------- 233 222 220 230 12-NOV-2013

227 223 219 230 13-NOV-2013

221 219 216 225 14-NOV-2013

222 214 212 220 15-NOV-2013

224 218 215 226 16-NOV-2013

224 218 216 227 17-NOV-2013

221 215 213 225 18-NOV-2013

221 217 210 223 19-NOV-2013

221 219 219 223 20-NOV-2013

217 214 216 NA 21-NOV-2013

211 208 NA NA 22-NOV-2013

220 NA NA NA 23-NOV-2013

215 NA NA NA 24-NOV-2013

212 NA NA NA 25-NOV-2013

213 NA NA NA 26-NOV-2013

213 NA NA NA 27-NOV-2013

213 NA NA NA 28-NOV-2013

212 NA NA NA 29-NOV-2013

215 NA NA NA 30-NOV-2013

218 NA NA NA 01-DEC-2013

223 NA NA NA 02-DEC-2013

219 NA NA NA 03-DEC-2013

215 NA NA NA 04-DEC-2013

N: GRAND MEAN: 221 222 223 221
SD: CV (%): 6.8 6.7 6.4 5.8

38 39 40 52 3.08 3.02 2.87 2.62

WIL Research Laboratories, LLC Report File: CVRSummary v1.07.rpt (06-06-12), WINH version 1.24 Printed On: 18-Dec-2013 8:25 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 34 of 56**Page 246 of 1107**INHALATION TABLE 6

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN CHAMBER VENTILATION RATE [L/MIN]

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 0 PPM 10000 PPM DATE CHAMBER: 5A 5B

----------------------------------------------------------------------------------------------------------------------------------- 10/14/13 114 116 10/15/13 113 116 10/16/13 115 116 10/17/13 116 122 10/18/13 116 119 10/19/13 122 113 10/20/13 112 126 10/21/13 112 116 10/22/13 107 136 10/23/13 107 112 10/24/13 101 122 10/25/13 101 109 10/26/13 102 96 10/27/13 100 102 10/28/13 120 109 10/29/13 118 109 10/30/13 112 106 10/31/13 116 109 11/01/13 116 106 11/02/13 117 109 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 35 of 56**Page 247 of 1107**INHALATION TABLE 6

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN CHAMBER VENTILATION RATE [L/MIN]

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 0 PPM 10000 PPM DATE CHAMBER: 5A 5B

----------------------------------------------------------------------------------------------------------------------------------- 11/03/13 118 112 11/04/13 116 112 11/05/13 116 109 11/06/13 118 109 11/07/13 119 99 11/08/13 124 99 11/09/13 126 122 11/10/13 128 109 11/11/13 122 102 11/12/13 111 109 11/13/13 112 102 11/14/13 116 102 11/15/13 123 116 11/16/13 116 102 11/17/13 117 106 11/18/13 120 106 11/19/13 124 112 11/20/13 114 102

----------------------------------------------------------------------------------------------------------------------------------- GRAND MEAN 115 111 SD 6.8 8.3 CV(%) 35.91 7.48 N 38 38 MANUALv1.0 12/15/2013 R:12/16/2013 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 36 of 56**Page 248 of 1107**INHALATION TABLE 7

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. TEST ATMOSPHERE HOMOGENEITY DETERMINATION

--------------------------------------------------------------------------------------------------------------------------------- TARGET: 50 PPM CHAMBER 2

--------------------------------------------------------------------------------------------------------------------------------- DATE SAMPLING LOCATION CONCENTRATION (PPM) % FROM REFERENCE MEAN %

--------------------------------------------------------------------------------------------------------------------------------- 08 OCT 2013 REFERENCE PORT 51 UPPER FRONT 50 -2.0

REFERENCE PORT 49 UPPER FRONT 47 -4.1

REFERENCE PORT 47 UPPER FRONT 46 -2.1 -2.7

REFERENCE PORT 51 LOWER FRONT 50 -2.0

REFERENCE PORT 49 LOWER FRONT 47 -4.1

REFERENCE PORT 47 LOWER FRONT 48 2.1 -1.3

REFERENCE PORT 50 UPPER REAR 50 0.0

REFERENCE PORT 49 UPPER REAR 47 -4.1

REFERENCE PORT 47 UPPER REAR 47 0.0 -1.4

REFERENCE PORT 50 LOWER REAR 50 0.0

REFERENCE PORT 49 LOWER REAR 47 -4.1

REFERENCE PORT 47 LOWER REAR 45 -4.3 -2.8

-------------------------------------------------------------------------------------------------------------------------------- PPM = PARTS PER MILLION 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 37 of 56**Page 249 of 1107**INHALATION TABLE 7

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. TEST ATMOSPHERE HOMOGENEITY DETERMINATION

--------------------------------------------------------------------------------------------------------------------------------- TARGET: 100 PPM CHAMBER 3

--------------------------------------------------------------------------------------------------------------------------------- DATE SAMPLING LOCATION CONCENTRATION (PPM) % FROM REFERENCE MEAN %

--------------------------------------------------------------------------------------------------------------------------------- 08 OCT 2013 REFERENCE PORT 96 UPPER FRONT 97 1.0

REFERENCE PORT 91 UPPER FRONT 92 1.1

REFERENCE PORT 92 UPPER FRONT 91 -1.1 0.3

REFERENCE PORT 96 LOWER FRONT 96 0.0

REFERENCE PORT 91 LOWER FRONT 90 -1.1

REFERENCE PORT 92 LOWER FRONT 91 -1.1 -0.7

REFERENCE PORT 96 UPPER REAR 91 -5.2

REFERENCE PORT 89 UPPER REAR 90 1.1

REFERENCE PORT 94 UPPER REAR 92 -2.1 -2.1

REFERENCE PORT 96 LOWER REAR 93 -3.1

REFERENCE PORT 89 LOWER REAR 90 1.1

REFERENCE PORT 94 LOWER REAR 93 -1.1 -1.0

-------------------------------------------------------------------------------------------------------------------------------- PPM = PARTS PER MILLION 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 38 of 56**Page 250 of 1107**INHALATION TABLE 7

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. TEST ATMOSPHERE HOMOGENEITY DETERMINATION

--------------------------------------------------------------------------------------------------------------------------------- TARGET: 175 PPM CHAMBER 4

--------------------------------------------------------------------------------------------------------------------------------- DATE SAMPLING LOCATION CONCENTRATION (PPM) % FROM REFERENCE MEAN %

--------------------------------------------------------------------------------------------------------------------------------- 08 OCT 2013 REFERENCE PORT 163 UPPER FRONT 165 1.2

REFERENCE PORT 165 UPPER FRONT 163 -1.2

REFERENCE PORT 162 UPPER FRONT 160 -1.2 -0.4

REFERENCE PORT 163 LOWER FRONT 164 0.6

REFERENCE PORT 165 LOWER FRONT 162 -1.8

REFERENCE PORT 162 LOWER FRONT 158 -2.5 -1.2

REFERENCE PORT 163 UPPER REAR 162 -0.6

REFERENCE PORT 162 UPPER REAR 159 -1.9

REFERENCE PORT 161 UPPER REAR 157 -2.5 -1.7

REFERENCE PORT 163 LOWER REAR 162 -0.6

REFERENCE PORT 162 LOWER REAR 159 -1.9

REFERENCE PORT 161 LOWER REAR 157 -2.5 -1.7

-------------------------------------------------------------------------------------------------------------------------------- PPM = PARTS PER MILLION 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 39 of 56**Page 251 of 1107**INHALATION TABLE 7

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. TEST ATMOSPHERE HOMOGENEITY DETERMINATION

--------------------------------------------------------------------------------------------------------------------------------- TARGET: 10,000 PPM CHAMBER 5B

--------------------------------------------------------------------------------------------------------------------------------- DATE SAMPLING LOCATION CONCENTRATION (PPM) % FROM REFERENCE MEAN %

--------------------------------------------------------------------------------------------------------------------------------- 21 NOV 2013 REFERENCE PORT 10,206 UPPER FRONT 10,259 0.5

REFERENCE PORT 10,079 UPPER FRONT 10,155 0.8

REFERENCE PORT 9,942 UPPER FRONT 10,102 1.6 1.0

REFERENCE PORT 10,206 LOWER REAR 10,235 0.3

REFERENCE PORT 10,079 LOWER REAR 10,324 2.4

REFERENCE PORT 9,942 LOWER REAR 10,171 2.3 1.7

-------------------------------------------------------------------------------------------------------------------------------- PPM = PARTS PER MILLION MANUALv1.0 01/27/2014 R:01/27/2014 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 40 of 56**Page 252 of 1107**PROJECT NO.:WIL-65501 PAGE 1 INHALTION TABLE 8 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE

----------------------------------------------------------------------------------------------------------------------------------- DAILY MEAN CONCENTRATION VALUES FOR 2-BROMO-3,3,3-TRIFLU (PPM)

RUN DATE 0 PPM 50 PPM 100 PPM 175 PPM

-----------------------------------------------------------------------------------------------------------------------------------
171 100 49 0 14-OCT-2013
0.0 2.1 4.8 7.9
NA 4.29 4.80 4.62 6 6 6 6 SD CV
N

170 106 56 0 15-OCT-2013
0.0 4.2 7.8 12.1
NA 7.50 7.36 7.12 6 6 6 6 SD CV
N

183 107 55 0 16-OCT-2013
0.0 1.3 4.2 12.9
NA 2.36 3.93 7.05 6 6 6 6 SD CV
N

176 103 47 0 17-OCT-2013
0.0 4.1 6.6 12.0
NA 8.72 6.41 6.82 6 6 6 6 SD CV
N

180 100 49 0 18-OCT-2013
0.0 2.3 3.9 5.3
NA 4.69 3.90 2.94 6 6 6 6 SD CV
N

182 99 51 0 19-OCT-2013
0.0 3.7 8.3 11.5
NA 7.25 8.38 6.32 6 6 6 6 SD CV
N

163 102 50 0 20-OCT-2013
0.0 2.5 5.9 26.8
NA 5.00 5.78 16.44 6 6 6 6 SD CV
N

WIL Research Laboratories, LLC Report File: CncSummary v1.09.rpt (04-24-13), WINH version 1.24 Printed On: 17-Dec-2013 15:13 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 41 of 56**Page 253 of 1107**PROJECT NO.:WIL-65501 PAGE 2 INHALTION TABLE 8 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE

----------------------------------------------------------------------------------------------------------------------------------- DAILY MEAN CONCENTRATION VALUES FOR 2-BROMO-3,3,3-TRIFLU (PPM)

RUN DATE 0 PPM 50 PPM 100 PPM 175 PPM

----------------------------------------------------------------------------------------------------------------------------------- 183 104 53 0 21-OCT-2013
0.0 2.5 3.8 14.3
NA 4.72 3.65 7.81 6 6 6 6 SD CV
N

186 99 52 0 22-OCT-2013
0.0 3.5 6.0 7.7
NA 6.73 6.06 4.14 6 6 6 6 SD CV
N

185 110 54 0 23-OCT-2013
0.0 1.8 5.5 18.7
NA 3.33 5.00 10.11 6 6 6 6 SD CV
N

176 90 49 0 24-OCT-2013
0.0 2.1 5.4 12.6
NA 4.29 6.00 7.16 6 6 6 6 SD CV
N

157 98 45 0 25-OCT-2013
0.0 4.2 7.1 12.0
NA 9.33 7.24 7.64 6 6 6 6 SD CV
N

173 96 52 0 26-OCT-2013
0.0 4.6 8.0 14.0
NA 8.85 8.33 8.09 6 6 6 6 SD CV
N

192 103 52 0 27-OCT-2013
0.0 3.1 12.7 6.2
NA 5.96 12.33 3.23 6 6 6 6 SD CV
N

WIL Research Laboratories, LLC Report File: CncSummary v1.09.rpt (04-24-13), WINH version 1.24 Printed On: 17-Dec-2013 15:13 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 42 of 56**Page 254 of 1107**PROJECT NO.:WIL-65501 PAGE 3 INHALTION TABLE 8 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE

----------------------------------------------------------------------------------------------------------------------------------- DAILY MEAN CONCENTRATION VALUES FOR 2-BROMO-3,3,3-TRIFLU (PPM)

RUN DATE 0 PPM 50 PPM 100 PPM 175 PPM

-----------------------------------------------------------------------------------------------------------------------------------
174 95 49 0 28-OCT-2013
0.0 2.6 3.7 8.1
NA 5.31 3.89 4.66 6 6 6 6 SD CV
N

167 96 47 0 29-OCT-2013
0.0 1.9 8.9 8.7
NA 4.04 9.27 5.21 6 6 6 6 SD CV
N

182 100 49 0 30-OCT-2013
0.0 3.2 9.2 6.9
NA 6.53 9.20 3.79 6 6 6 6 SD CV
N

176 106 52 0 31-OCT-2013
0.0 4.2 5.6 10.9
NA 8.08 5.28 6.19 6 6 6 6 SD CV
N

174 106 52 0 01-NOV-2013
0.0 2.9 5.0 5.3
NA 5.58 4.72 3.05 6 6 6 6 SD CV
N

184 105 51 0 02-NOV-2013
0.0 2.1 4.9 8.8
NA 4.12 4.67 4.78 6 6 6 6 SD CV
N

167 96 47 0 03-NOV-2013
0.0 3.5 4.8 10.3
NA 7.45 5.00 6.17 6 6 6 6 SD CV
N

WIL Research Laboratories, LLC Report File: CncSummary v1.09.rpt (04-24-13), WINH version 1.24 Printed On: 17-Dec-2013 15:13 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 43 of 56**Page 255 of 1107**PROJECT NO.:WIL-65501 PAGE 4 INHALTION TABLE 8 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE

----------------------------------------------------------------------------------------------------------------------------------- DAILY MEAN CONCENTRATION VALUES FOR 2-BROMO-3,3,3-TRIFLU (PPM)

RUN DATE 0 PPM 50 PPM 100 PPM 175 PPM

----------------------------------------------------------------------------------------------------------------------------------- 163 105 49 0 04-NOV-2013
0.0 2.1 4.0 6.7
NA 4.29 3.81 4.11 6 6 6 6 SD CV
N

183 103 53 0 05-NOV-2013
0.0 5.0 9.9 14.3
NA 9.43 9.61 7.81 6 6 6 6 SD CV
N

184 104 55 0 06-NOV-2013
0.0 2.4 7.3 9.6
NA 4.36 7.02 5.22 6 6 6 6 SD CV
N

171 100 50 0 07-NOV-2013
0.0 5.6 11.4 17.9
NA 11.20 11.40 10.47 6 6 6 6 SD CV
N

173 94 45 0 08-NOV-2013
0.0 4.9 7.1 7.6
NA 10.89 7.55 4.39 6 6 6 6 SD CV
N

191 98 56 0 09-NOV-2013
0.0 2.0 3.2 5.0
NA 3.57 3.27 2.62 6 6 6 6 SD CV
N

155 106 52 0 10-NOV-2013
0.0 4.9 2.6 64.9
NA 9.42 2.45 41.87
7 6 5 6 SD CV
N

WIL Research Laboratories, LLC Report File: CncSummary v1.09.rpt (04-24-13), WINH version 1.24 Printed On: 17-Dec-2013 15:13 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 44 of 56**Page 256 of 1107**PROJECT NO.:WIL-65501 PAGE 5 INHALTION TABLE 8 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE

----------------------------------------------------------------------------------------------------------------------------------- DAILY MEAN CONCENTRATION VALUES FOR 2-BROMO-3,3,3-TRIFLU (PPM)

RUN DATE 0 PPM 50 PPM 100 PPM 175 PPM

----------------------------------------------------------------------------------------------------------------------------------- 172 96 47 0 11-NOV-2013
0.0 3.1 6.0 11.9
NA 6.60 6.25 6.92 6 6 6 6 SD CV
N

163 93 46 0 12-NOV-2013
0.0 5.6 13.0 24.2
NA 12.17 13.98 14.85 6 6 6 6 SD CV
N

173 97 49 0 13-NOV-2013
0.0 2.0 6.1 10.8
NA 4.08 6.29 6.24 6 6 6 6 SD CV
N

177 98 50 0 14-NOV-2013
0.0 4.5 9.4 19.5
NA 9.00 9.59 11.02 6 6 6 6 SD CV
N

184 106 54 0 15-NOV-2013
0.0 1.2 4.2 4.1
NA 2.22 3.96 2.23 6 6 6 6 SD CV
N

173 103 48 0 16-NOV-2013
0.0 5.5 9.3 15.8
NA 11.46 9.03 9.13 6 6 6 6 SD CV
N

187 108 54 0 17-NOV-2013
0.0 1.6 2.7 3.3
NA 2.96 2.50 1.76 6 6 6 6 SD CV
N

WIL Research Laboratories, LLC Report File: CncSummary v1.09.rpt (04-24-13), WINH version 1.24 Printed On: 17-Dec-2013 15:13 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 45 of 56**Page 257 of 1107**PROJECT NO.:WIL-65501 PAGE 6 INHALTION TABLE 8 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE

----------------------------------------------------------------------------------------------------------------------------------- DAILY MEAN CONCENTRATION VALUES FOR 2-BROMO-3,3,3-TRIFLU (PPM)

RUN DATE 0 PPM 50 PPM 100 PPM 175 PPM

----------------------------------------------------------------------------------------------------------------------------------- 182 107 54 0 18-NOV-2013
0.0 1.3 2.9 5.2
NA 2.41 2.71 2.86 6 6 6 6 SD CV
N

162 107 47 0 19-NOV-2013
0.0 2.1 12.5 12.2
NA 4.47 11.68 7.53 6 6 6 6 SD CV
N

153 96 44 0 20-NOV-2013
0.0 4.2 13.4 18.9
NA 9.55 13.96 12.35 6 6 6 6 SD CV
N

178 104 51 NA 21-NOV-2013

NA 3.4 4.7 15.4
NA 6.67 4.52 8.65 0 6 6 6 SD CV
N

183 105 NA NA 22-NOV-2013

NA NA 4.8 8.6
NA NA 4.57 4.70 0 0 6 6 SD CV
N

167 NA NA NA 23-NOV-2013

NA NA NA 8.0
NA NA NA 4.79 0 0 0 6 SD CV
N

170 NA NA NA 24-NOV-2013

NA NA NA 16.6
NA NA NA 9.76 0 0 0 6 SD CV
N

WIL Research Laboratories, LLC Report File: CncSummary v1.09.rpt (04-24-13), WINH version 1.24 Printed On: 17-Dec-2013 15:13 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 46 of 56**Page 258 of 1107**PROJECT NO.:WIL-65501 PAGE 7 INHALTION TABLE 8 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE

----------------------------------------------------------------------------------------------------------------------------------- DAILY MEAN CONCENTRATION VALUES FOR 2-BROMO-3,3,3-TRIFLU (PPM)

RUN DATE 0 PPM 50 PPM 100 PPM 175 PPM

----------------------------------------------------------------------------------------------------------------------------------- 178 NA NA NA 25-NOV-2013

NA NA NA 6.0
NA NA NA 3.37 0 0 0 6 SD CV
N

180 NA NA NA 26-NOV-2013

NA NA NA 12.3
NA NA NA 6.83 0 0 0 6 SD CV
N

195 NA NA NA 27-NOV-2013

NA NA NA 30.5
NA NA NA 15.64 0 0 0 5 SD CV
N

166 NA NA NA 28-NOV-2013

NA NA NA 11.9
NA NA NA 7.17 0 0 0 6 SD CV
N

176 NA NA NA 29-NOV-2013

NA NA NA 16.2
NA NA NA 9.20 0 0 0 6 SD CV
N

182 NA NA NA 30-NOV-2013

NA NA NA 20.9
NA NA NA 11.48 0 0 0 6 SD CV
N

164 NA NA NA 01-DEC-2013

NA NA NA 18.4
NA NA NA 11.22 0 0 0 6 SD CV
N

WIL Research Laboratories, LLC Report File: CncSummary v1.09.rpt (04-24-13), WINH version 1.24 Printed On: 17-Dec-2013 15:13 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 47 of 56**Page 259 of 1107**PROJECT NO.:WIL-65501 PAGE 8 INHALTION TABLE 8 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE

----------------------------------------------------------------------------------------------------------------------------------- DAILY MEAN CONCENTRATION VALUES FOR 2-BROMO-3,3,3-TRIFLU (PPM)

RUN DATE 0 PPM 50 PPM 100 PPM 175 PPM

----------------------------------------------------------------------------------------------------------------------------------- 166 NA NA NA 02-DEC-2013

NA NA NA 12.3
NA NA NA 7.41 0 0 0 6 SD CV
N

166 NA NA NA 03-DEC-2013

NA NA NA 14.1
NA NA NA 8.49 0 0 0 6 SD CV
N

138 NA NA NA 04-DEC-2013

NA NA NA 19.8
NA NA NA 14.35 0 0 0 6 SD CV
N

N: SD: CV (%): 0.0 3.2 4.8 10.7

38 39 40 52 NA 6.40 4.75 6.15 GRAND MEAN: 0 50 101 174

WIL Research Laboratories, LLC Report File: CncSummary v1.09.rpt (04-24-13), WINH version 1.24 Printed On: 17-Dec-2013 15:13 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 48 of 56**Page 260 of 1107**INHALATION TABLE 9

PROJECT NO.:WIL-65501I RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN TEST ATMOSPHERE CONCENTRATIONS

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 0 PPM 10000 PPM CHAMBER: 5A 5B

-----------------------------------------------------------------------------------------------------------------------------------

EXPOSURE ON 14-OCT-13 MEAN 0. 11046. SD 0.0 1654.6 CV(%) 0.00 14.98 N 5 2

EXPOSURE ON 15-OCT-13 MEAN 0. 9316. SD 0.0 1437.5 CV(%) 0.00 15.43 N 6 2

EXPOSURE ON 16-OCT-13 MEAN 0. 10272. SD 0.0 1399.4 CV(%) 0.00 13.62 N 5 2

EXPOSURE ON 17-OCT-13 MEAN 0. 9843. SD 0.0 982.2 CV(%) 0.00 9.98 N 5 2

EXPOSURE ON 18-OCT-13 MEAN 0. 10126. SD 0.0 1388.8 CV(%) 0.00 13.71 N 6 2

CV (%) = COEFFICIENT OF VARIATION CONCENTRATION IN: PPM 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 49 of 56**Page 261 of 1107**INHALATION TABLE 9

PROJECT NO.:WIL-65501I RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN TEST ATMOSPHERE CONCENTRATIONS

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 0 PPM 10000 PPM CHAMBER: 5A 5B

-----------------------------------------------------------------------------------------------------------------------------------

EXPOSURE ON 19-OCT-13 MEAN 0. 9763. SD 0.0 1517.5 CV(%) 0.00 15.54 N 6 2

EXPOSURE ON 20-OCT-13 MEAN 0. 9792. SD 0.0 1192.2 CV(%) 0.00 12.18 N 6 2

EXPOSURE ON 21-OCT-13 MEAN 0. 10272. SD 0.0 1349.9 CV(%) 0.00 13.14 N 6 2

EXPOSURE ON 22-OCT-13 MEAN 0. 10887. SD 0.0 1169.6 CV(%) 0.00 10.74 N 6 2

EXPOSURE ON 23-OCT-13 MEAN 0. 9637. SD 0.0 1453.8 CV(%) 0.00 15.09 N 6 2

CV (%) = COEFFICIENT OF VARIATION CONCENTRATION IN: PPM 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 50 of 56**Page 262 of 1107**INHALATION TABLE 9

PROJECT NO.:WIL-65501I RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN TEST ATMOSPHERE CONCENTRATIONS

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 0 PPM 10000 PPM CHAMBER: 5A 5B

-----------------------------------------------------------------------------------------------------------------------------------

EXPOSURE ON 24-OCT-13 MEAN 0. 10620. SD 0.0 604.6 CV(%) 0.00 5.69 N 5 2

EXPOSURE ON 25-OCT-13 MEAN 0. 9258. SD 0.0 1195.7 CV(%) 0.00 12.92 N 5 2

EXPOSURE ON 26-OCT-13 MEAN 0. 10821. SD 0.0 1497.7 CV(%) 0.00 13.84 N 6 2

EXPOSURE ON 27-OCT-13 MEAN 0. 10004. SD 0.0 1554.9 CV(%) 0.00 15.54 N 6 2

EXPOSURE ON 28-OCT-13 MEAN 0. 10602. SD 0.0 918.5 CV(%) 0.00 8.66 N 6 2

CV (%) = COEFFICIENT OF VARIATION CONCENTRATION IN: PPM 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 51 of 56**Page 263 of 1107**INHALATION TABLE 9

PROJECT NO.:WIL-65501I RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN TEST ATMOSPHERE CONCENTRATIONS

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 0 PPM 10000 PPM CHAMBER: 5A 5B

-----------------------------------------------------------------------------------------------------------------------------------

EXPOSURE ON 29-OCT-13 MEAN 0. 9315. SD 0.0 882.5 CV(%) 0.00 9.47 N 6 2

EXPOSURE ON 30-OCT-13 MEAN 0. 10609. SD 0.0 1139.1 CV(%) 0.00 10.74 N 6 2

EXPOSURE ON 31-OCT-13 MEAN 0. 10579. SD 0.0 1364.0 CV(%) 0.00 12.89 N 6 2

EXPOSURE ON 01-NOV-13 MEAN 0. 10839. SD 0.0 1433.3 CV(%) 0.00 13.22 N 6 2

EXPOSURE ON 02-NOV-13 MEAN 0. 9936. SD 0.0 978.6 CV(%) 0.00 9.85 N 6 2

CV (%) = COEFFICIENT OF VARIATION CONCENTRATION IN: PPM 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 52 of 56**Page 264 of 1107**INHALATION TABLE 9

PROJECT NO.:WIL-65501I RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN TEST ATMOSPHERE CONCENTRATIONS

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 0 PPM 10000 PPM CHAMBER: 5A 5B

-----------------------------------------------------------------------------------------------------------------------------------

EXPOSURE ON 03-NOV-13 MEAN 0. 11321. SD 0.0 1626.3 CV(%) 0.00 14.37 N 6 2

EXPOSURE ON 04-NOV-13 MEAN 0. 9710. SD 0.0 1056.4 CV(%) 0.00 10.88 N 5 2

EXPOSURE ON 05-NOV-13 MEAN 0. 10867. SD 0.0 987.8 CV(%) 0.00 9.09 N 6 2

EXPOSURE ON 06-NOV-13 MEAN 0. 10030. SD 0.0 892.4 CV(%) 0.00 8.90 N 6 2

EXPOSURE ON 07-NOV-13 MEAN 0. 9682. SD 0.0 1084.0 CV(%) 0.00 11.20 N 6 2

CV (%) = COEFFICIENT OF VARIATION CONCENTRATION IN: PPM 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 53 of 56**Page 265 of 1107**INHALATION TABLE 9

PROJECT NO.:WIL-65501I RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6 SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN TEST ATMOSPHERE CONCENTRATIONS

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 0 PPM 10000 PPM CHAMBER: 5A 5B

-----------------------------------------------------------------------------------------------------------------------------------

EXPOSURE ON 08-NOV-13 MEAN 0. 10189. SD 0.0 951.1 CV(%) 0.00 9.33 N 6 2

EXPOSURE ON 09-NOV-13 MEAN 0. 9015. SD 0.0 1420.6 CV(%) 0.00 15.76 N 6 2

EXPOSURE ON 10-NOV-13 MEAN 0. 10376. SD 0.0 1555.6 CV(%) 0.00 14.99 N 6 2

EXPOSURE ON 11-NOV-13 MEAN 0. 9829. SD 0.0 1076.9 CV(%) 0.00 10.96 N 6 2

EXPOSURE ON 12-NOV-13 MEAN 0. 9969. SD 0.0 520.4 CV(%) 0.00 5.22 N 6 2

CV (%) = COEFFICIENT OF VARIATION CONCENTRATION IN: PPM 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 54 of 56**Page 266 of 1107**INHALATION TABLE 9

PROJECT NO.:WIL-65501I RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7 SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN TEST ATMOSPHERE CONCENTRATIONS

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 0 PPM 10000 PPM CHAMBER: 5A 5B

-----------------------------------------------------------------------------------------------------------------------------------

EXPOSURE ON 13-NOV-13 MEAN 0. 10522. SD 0.0 606.7 CV(%) 0.00 5.77 N 6 2

EXPOSURE ON 14-NOV-13 MEAN 0. 9773. SD 0.0 493.6 CV(%) 0.00 5.05 N 6 2

EXPOSURE ON 15-NOV-13 MEAN 0. 9373. SD 0.0 751.7 CV(%) 0.00 8.02 N 6 2

EXPOSURE ON 16-NOV-13 MEAN 0. 8667. SD 0.0 533.2 CV(%) 0.00 6.15 N 6 2

EXPOSURE ON 17-NOV-13 MEAN 0. 10580. SD 0.0 686.6 CV(%) 0.00 6.49 N 6 2

CV (%) = COEFFICIENT OF VARIATION CONCENTRATION IN: PPM 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 55 of 56**Page 267 of 1107**INHALATION TABLE 9

PROJECT NO.:WIL-65501I RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8 SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN TEST ATMOSPHERE CONCENTRATIONS

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 0 PPM 10000 PPM CHAMBER: 5A 5B

-----------------------------------------------------------------------------------------------------------------------------------

EXPOSURE ON 18-NOV-13 MEAN 0. 10285. SD 0.0 610.9 CV(%) 0.00 5.94 N 6 2

EXPOSURE ON 19-NOV-13 MEAN 0. 9867. SD 0.0 516.9 CV(%) 0.00 5.24 N 6 2

EXPOSURE ON 20-NOV-13 MEAN 0. 9305. SD 0.0 947.5 CV(%) 0.00 10.18 N 6 2

ALL STUDY DAYS COMBINED MEAN 0. 10076. SD 0.0 607.9 CV(%) 0.00 6.03 N 38 38

-----------------------------------------------------------------------------------------------------------------------------------

CV (%) = COEFFICIENT OF VARIATION CONCENTRATION IN: PPM PCHCSUv4.06 01/27/2014 R:01/27/2014 

## WIL

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene American Pacific Corporation

- - Inhalation Report Page 56 of 56**Page 268 of 1107**

## WI L

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene

American Pacific Corporation



# APPENDIX **D**

Animal Room Environmental Conditions

**Page 269 of 1107**TEST SYSTEM: DATE IN TIME IN

DATE OUT TIME OUT 09/26/13 08:00

12/05/13 18:00

RAT HIGH HUMIDITY %RH: LOW HUMIDITY %RH: HIGH TEMPERATURE °F: LOW TEMPERATURE °F: ROOM SPECIFICATIONS: 66.0 76.0 30.0

70.0 STUDY SPECIFICATIONS:

HIGH TEMPERATURE °C: LOW TEMPERATURE °C: 18.9 24.4 65501

B ROOM 38

DATE SECONDARY TEMP PRIMARY HUM SECONDARY HUM PRIMARY TEMP

MEAN (°F) MEAN (°C) MEAN (°F) MEAN (°C) MEAN (%RH) MEAN (%RH)

09/26/13 71.5 44.7 71.9 45.8 21.9 22.2

09/27/13 70.8 44.3 71.5 45.1 21.6 21.9

09/28/13 70.9 44.5 71.6 45.3 21.6 22.0

09/29/13 70.9 46.3 71.7 46.9 21.6 22.1

09/30/13 70.8 46.9 71.5 47.5 21.6 21.9

10/01/13 71.2 46.0 71.8 46.6 21.8 22.1

10/02/13 71.0 47.7 71.5 48.4 21.7 21.9

10/03/13 71.4 47.6 71.9 48.1 21.9 22.2

10/04/13 71.1 48.6 71.5 49.2 21.7 21.9

10/05/13 70.9 49.7 71.5 50.2 21.6 21.9

10/06/13 71.0 49.0 71.5 49.6 21.7 21.9

10/07/13 71.0 44.2 71.7 44.7 21.7 22.1

10/08/13 70.5 43.2 71.3 43.9 21.4 21.8

10/09/13 70.9 42.6 71.6 43.4 21.6 22.0

10/10/13 70.9 41.8 71.6 42.6 21.6 22.0

10/11/13 70.9 43.6 71.5 44.5 21.6 21.9

10/12/13 71.2 44.5 71.7 45.2 21.8 22.1

10/13/13 70.9 46.2 71.5 46.7 21.6 21.9

10/14/13 71.5 45.1 72.1 45.9 21.9 22.3 

### RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE

65501

65 - AMERICAN PACIFIC CORP. Page 1 of 6 TEMPERATURE/HUMIDITY - STUDY SUMMARY REPORT PROJECT NO.:WIL-

SPONSOR:**Page 270 of 1107**DATE SECONDARY TEMP PRIMARY HUM SECONDARY HUM PRIMARY TEMP

MEAN (°F) MEAN (°C) MEAN (°F) MEAN (°C) MEAN (%RH) MEAN (%RH)

10/15/13 70.7 46.4 71.5 47.1 21.5 21.9

10/16/13 71.3 48.1 71.9 48.6 21.8 22.2

10/17/13 70.6 45.3 71.5 46.0 21.4 21.9

10/18/13 70.4 44.4 71.1 45.4 21.3 21.7

10/19/13 71.0 43.2 71.8 43.8 21.7 22.1

10/20/13 71.3 42.1 72.1 42.8 21.8 22.3

10/21/13 70.9 44.6 71.5 45.6 21.6 21.9

10/22/13 71.0 41.7 71.7 42.5 21.7 22.1

10/23/13 70.8 42.0 71.7 42.6 21.6 22.1

10/24/13 70.8 41.8 71.8 42.5 21.6 22.1

10/25/13 72.5 40.3 73.3 40.6 22.5 22.9

10/26/13 71.1 41.3 72.1 42.0 21.7 22.3

10/27/13 71.2 41.6 72.1 42.2 21.8 22.3

10/28/13 70.3 42.4 71.1 43.3 21.3 21.7

10/29/13 70.6 42.3 71.3 43.2 21.4 21.8

10/30/13 70.8 46.1 71.3 47.3 21.6 21.8

10/31/13 71.6 48.4 72.1 49.2 22.0 22.3

11/01/13 70.4 45.5 71.2 46.4 21.3 21.8

11/02/13 70.9 43.8 71.7 44.4 21.6 22.1

11/03/13 70.9 43.4 71.7 44.3 21.6 22.1

11/04/13 71.0 42.5 71.7 43.4 21.7 22.1

11/05/13 70.9 43.1 71.6 43.9 21.6 22.0

11/06/13 71.0 45.2 71.5 46.2 21.7 21.9 

### RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE

65501

65 - AMERICAN PACIFIC CORP. Page 2 of 6 TEMPERATURE/HUMIDITY - STUDY SUMMARY REPORT PROJECT NO.:WIL-

SPONSOR:**Page 271 of 1107**DATE SECONDARY TEMP PRIMARY HUM SECONDARY HUM PRIMARY TEMP

MEAN (°F) MEAN (°C) MEAN (°F) MEAN (°C) MEAN (%RH) MEAN (%RH)

11/07/13 71.0 42.9 71.7 43.9 21.7 22.1

11/08/13 70.9 42.2 71.7 43.1 21.6 22.1

11/09/13 71.9 41.2 72.5 41.9 22.2 22.5

11/10/13 72.1 41.0 72.7 41.4 22.3 22.6

11/11/13 70.6 41.8 71.4 42.6 21.4 21.9

11/12/13 71.2 40.6 72.0 41.2 21.8 22.2

11/13/13 70.8 41.6 71.6 42.3 21.6 22.0

11/14/13 71.6 40.9 72.3 41.6 22.0 22.4

11/15/13 71.6 41.1 72.2 42.0 22.0 22.3

11/16/13 71.6 43.6 72.2 44.4 22.0 22.3

11/17/13 71.5 47.8 72.0 48.5 21.9 22.2

11/18/13 71.2 41.9 72.0 42.5 21.8 22.2

11/19/13 71.0 41.3 71.8 42.0 21.7 22.1

11/20/13 70.8 41.0 71.6 42.0 21.6 22.0

11/21/13 71.2 41.6 71.8 42.4 21.8 22.1

11/22/13 70.8 42.8 71.4 43.5 21.6 21.9

11/23/13 70.9 40.3 71.7 41.2 21.6 22.1

11/24/13 71.5 39.1 72.4 39.8 21.9 22.4

11/25/13 70.6 39.9 71.5 40.8 21.4 21.9

11/26/13 70.8 39.5 71.8 40.1 21.6 22.1

11/27/13 70.7 39.3 71.8 39.8 21.5 22.1

11/28/13 70.7 38.9 71.8 39.5 21.5 22.1

11/29/13 70.8 38.6 71.8 39.3 21.6 22.1 

### RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE

65501

65 - AMERICAN PACIFIC CORP. Page 3 of 6 TEMPERATURE/HUMIDITY - STUDY SUMMARY REPORT PROJECT NO.:WIL-

SPONSOR:**Page 272 of 1107**DATE SECONDARY TEMP PRIMARY HUM SECONDARY HUM PRIMARY TEMP

MEAN (°F) MEAN (°C) MEAN (°F) MEAN (°C) MEAN (%RH) MEAN (%RH)

11/30/13 71.1 38.7 72.0 39.3 21.7 22.2

12/01/13 70.9 39.1 71.9 39.7 21.6 22.2

12/02/13 70.9 39.5 71.9 40.2 21.6 22.2

12/03/13 70.8 40.2 71.7 40.8 21.6 22.1

12/04/13 70.8 42.7 71.4 43.4 21.6 21.9

12/05/13 72.1 45.2 72.5 45.9 22.3 22.5

SUMMARY OF DAILY MEANS

71.0 70.3 72.5 MEAN MIN MAX

PRIMARY TEMP °F:

PRIMARY TEMP °C:

PRIMARY HUM %RH:

N DAYS 21.7 21.3 22.5

43.2 38.6 49.7 71.8

71 71.1 73.3 SECONDARY TEMP °F:

SECONDARY TEMP °C:

SECONDARY HUM %RH: 22.1 21.7 22.9

43.9 39.3 50.2



### RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE

65501

65 - AMERICAN PACIFIC CORP. Page 4 of 6 TEMPERATURE/HUMIDITY - STUDY SUMMARY REPORT PROJECT NO.:WIL-

SPONSOR:**Page 273 of 1107**N DAYS LAST DAY FIRST DAY MEAN

N SAMPLES SD MAX MIN B ROOM 38 SUMMARY OF HOURLY VALUES

71.0 43.2

64.1

76.3

1689 34.4

63.1

1689 1.82 3.91 PRIMARY TEMP PRIMARY HUM

09/26/13

12/05/13

71 71.8

66.5

76.2

1689 1.67 43.9

34.7

64.5

1689 4.20 °F

°F

°F °F

°F

°F SECONDARY TEMP SECONDARY HUM

%RH

%RH

%RH %RH

%RH

%RH

0.04 0.10 0.04 0.10 SE 21.7

17.8

24.6

1.01 °C

°C

°C

0.02 22.1

19.2

24.6

0.93 °C

°C

°C

0.02 

### RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE

65501

65 - AMERICAN PACIFIC CORP. Page 5 of 6 TEMPERATURE/HUMIDITY - STUDY SUMMARY REPORT PROJECT NO.:WIL-

SPONSOR:**Page 274 of 1107**STUDY 65501 SUMMARY OF HOURLY VALUES

PRIMARY TEMP

LAST DAY FIRST DAY MEAN

N SAMPLES SD MAX MIN 71.0 43.2

64.1

76.3

1689 34.4

63.1

1689 1.82 3.91 °F PRIMARY HUM

09/26/13

12/05/13

71 71.8

66.5

76.2

1689 1.67 43.9

34.7

64.5

1689 4.20 °F

°F

°F °F

°F

N DAYS SECONDARY TEMP SECONDARY HUM

%RH

%RH

%RH %RH

%RH

%RH

0.04 0.10 0.04 0.10 SE 21.7

17.8

24.6

1.01 °C

°C

°C

0.02 °C 22.1

19.2

24.6

0.93 °C

°C

0.02 

### RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE

65501

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SPONSOR:

WIL METASYS VERSION 2.27 09:28 24-Jan-14**Page 275 of 1107**

## WI L

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- Bromo

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- Trifluoropropene

American Pacific Corporation



# APPENDIX **E**

Pathology Report (WIL Research)

**Page 276 of 1107**

## WIL-65501 2-Bromo-3,3,3-Trifluoropropene American Pacific Corporation

-1- An Inhalation Reproduction/Developmental Toxicity Screening Study of 2-Br omo-3,3,3-Trifluoropropene in Rats

Pathology Report

WIL Research Pathology Department

**Page 277 of 1107**

## WIL-65501 2-Bromo-3,3,3-Trifluoropropene American Pacific Corporation

-2- 

# T ABLE OF 

# C ONTENTS


## Page

Table of Contents ....................................................................................... 2

1. Introduction ................................................................................................ 3 2. Study Design ............................................................................................... 3

3. Methods ....................................................................................................... 4 3.1. Anatomic Pathology..................................................................................... 4 3.1.1. Macroscopic Examination ........................................................................... 4 3.1.2. Organ Weights ............................................................................................. 5 3.1.3. Microscopic Examination ............................................................................ 5 3.2. Data Interpretation ....................................................................................... 7

4. Results ......................................................................................................... 8

4.1. Survival ........................................................................................................ 8

4.2. Gross Observations ...................................................................................... 8 4.3. Organ Weights ............................................................................................. 8 4.4. Histologic Changes ...................................................................................... 9

5. Conclusions ................................................................................................. 9

6. References ................................................................................................. 10 7. Report Submission ................................................................................... 11

**Page 278 of 1107**

## WIL-65501 2-Bromo-3,3,3-Trifluoropropene American Pacific Corporation

-3- 

# 1. I NTRODUCTION 

## The objective of this study was to provide preliminary information on the potential

adverse effects of the test substance on male and female reproduction within the scope of
a screening study. This encompassed gona dal function, mating behavior, conception,
parturition, and la ctation of the F 0 

## generation and the devel opment of offspring from
conception through day 4 of postnatal life . This pathology report addresses the
anatomical pathology e ndpoints of the study.



# 2. S TUDY 

# D ESIGN 

## Male and female Crl:CD(SD) rats were ad ministered filtered air or 2-Bromo-3,3,3-
Trifluoropropene atmospheres as a daily 6-hour whole-body inhalation exposure for
animals in Groups 1, 2, 3, and 4, as indicate d in the following table. 2-Bromo-3,3,3-
Trifluoropropene atmospheres were admini stered as a daily 5-minute whole-body
exposure for animals in Group 5.

F 0 

## males, 71-85 days of age at initiation of dosing, were exposed for a minimum of
14 days prior to mating and c ontinuing until the day prior to the scheduled euthanasia.
The total exposure period for the F 0 

## males encompassed 28-29 consecutive days.

F 0 

## females, 61-75 days at the start of estrous cycle determ ination, were exposed for a
minimum of 14 days prior to mating and c ontinuing throughout mating until gestation
day 20, inclusively. F 0 

## females that did not deliver were exposed until 1 day prior to
scheduled euthanasia on post-ma ting or post-cohabitation day 25.

Group Number Treatment Exposure Level (ppm) Number of Animals Males Females
1 Filtered Air 0 12 12 2 2-Bromo-3,3,3-Trifluoropropene 50 12 12 3 2-Bromo-3,3,3-Trifluoropropene 100 12 12 4 2-Bromo-3,3,3-Trifluoropropene 175 12 12 5 2-Bromo-3,3,3-Trifluoropropene 10,000 12 12

**Page 279 of 1107**

## WIL-65501 2-Bromo-3,3,3-Trifluoropropene American Pacific Corporation

-4- 

# 3. M ETHODS


# 3.1. A NATOMIC 

# P ATHOLOGY


# 3.1.1. M ACROSCOPIC 

# E XAMINATION 

## Complete postmortem examinations were performed on all animals euthanized at the
scheduled necropsy. Animals were euth anized by carbon dioxide inhalation and
exsanguinated. For F 0 

## females, the numbers of former implantation sites and corpora

lutea were recorded. At the time of necr opsy, the following tissues and organs were
collected and placed in 10% neutral-buffered formalin fixative unless otherwise noted:

Brain Coagulating glands Kidneys Liver (sections of 2 lobes) Lungs Mammary glands (females only) Ovaries a 

## and oviduct (2) Pituitary gland Prostate gland Seminal vesicles (2) Spleen Testes with epididymides (2) b


## and vas deferens Uterus c 

## with cervix and vagina All gross lesions d

a 

## - Ovaries were fixed in 10% neutral-buffe red formalin for appr oximately 48 hours following which all ov aries were transferred to 70% ethanol.
b 

## - Testis (right) and epididym is (right and remainder of le ft) were fixed in modified Davidson’s solution; care wa s taken to ensure separation between the left and right
organs.

c 

## - Any uterus stained in 10% ammonium solution for detect ion of implantation sites was discarded and not preserved in 10% neutral buffered formalin.
d 

## - Representative sections of corresponding or gans from a sufficient number of controls were retained for comp arison, if possible.

**Page 280 of 1107**

## WIL-65501 2-Bromo-3,3,3-Trifluoropropene American Pacific Corporation

-5- 

# 3.1.2. O RGAN 

# W EIGHTS 

## The following organs were weighed from all F 0 

## animals at the scheduled necropsies:

Brain Epididymides (total and caudal)* Kidneys Liver Lungs Ovaries (without oviducts) Pituitary gland Spleen Testes*

Paired organs were weighed together. De signated (*) paired organs were weighed
separately. Organ to final body weight and organ to brain wei ght ratios were calculated.



# 3.1.3. M ICROSCOPIC 

# E XAMINATION 

## Microscopic examination of routinely prepared hematoxy lin-eosin stained paraffin
sections was performed on the following tis sues collected at necropsy from all F 0 

## parental
animals from the control, 175, and 10,000 ppm groups. Sections of the testes and
epididymides were also stained with Periodi c Acid Schiff’s stain (PAS) and hematoxylin.

Gross lesions were examined from all animal s and correlated to microscopic findings if
possible.

**Page 281 of 1107**

## WIL-65501 2-Bromo-3,3,3-Trifluoropropene American Pacific Corporation

-6- Cervix Coagulating gland Epididymides a,b 

## Lungs Mammary glands (female only) Ovaries c 

## Pituitary gland Prostate gland Seminal vesicles Spleen Testes a,b


## Uterus Vagina Vas deferens All gross (internal) lesions

a 

## - Sections of 2-4 microns of the testis (transverse) and epididymis (longitudinal) were stained in PAS and hematoxylin in add ition to routine hematoxylin and eosin staining.
b 

## - If the left tes tis or epididymis was noted with a gross lesion, the left testis and epididymis were fixed in modified Davi dson’s solution and the right testis and epididymis were homogenized.

c 

## - All ovaries were paraffin embedded. Five (5) sections were taken approximately 100 μ m apart from the inner middle of each ovary from all the F 0 

## females in the control, 175, and 10,000 ppm groups at sche duled termination and for any females suspected of reduced fertility. In a ddition, a single section was taken for a qualitative bilateral eval uation of each ovary. A quantitative histopathologic evaluation of multiple sect ions was conducted. This examination included enumeration of the total number of primordi al follicles accordi ng to the methods of Bolon et al ., ( 1997 ), Bucci et al ., ( 1997 ), and Picut et al ., ( 2008 ).

Stained histologic sections were examined by light microscopy and observations were
entered in the WIL Toxicology Data Management System (WTDMSTM) by the
pathologist. Histologic sectio ns were of adequate size and quality for detailed evaluation,
and the number of tissues examined from each treatment group was sufficient to allow

detection of test substance -related histologic alterations.

Severity grades were assigned to non-neoplas tic histopathologic diagnoses in compliance
with the following general guidelines, as pr esented in the following table. Severity
grades were assigned based on the severity of alterations in the examined histologic
sections and may not reflect the overall severi ty of the pathologic process in the entire
tissue, organ, or animal. The WTDMSTM histopathology tables contain all of the

recorded data and serve as th e basis for this narrative report.

**Page 282 of 1107**

## WIL-65501 2-Bromo-3,3,3-Trifluoropropene American Pacific Corporation

-7- Unremarkable Tissue considered to be within normal limits, under the conditions of the study and considering the age, sex, and strain of the animal concerned. Present A non-gradable histologic change for which no additional information would be gained by assigning a severity grade ( e.g . cyst).

Grade 1 (Minimal) A histologic change that barely exceeds that which is considered to be within normal limits. This change is unlikely to produce any functional impairment.

Grade 2 (Mild) A histologic change that is easily identified but of limited severity. This change probably does not produce any functional impairment.

Grade 3 (Moderate) A histologic change that is a prominent feature of the tissue but not of maximal severity. Limite d tissue or organ dysfunction is possible.

Grade 4 (Severe) A histologic change that is an overwhelming feature of the tissue and that may cause significan t tissue or orga n dysfunction.



# 3.2. D ATA 

# I NTERPRETATION 

## In the discussion of organ weights and mean nu mber of ovarian primordial follicles, the
indication of higher or lower mean values re fers to a statistically significant [p<0.05 or
p<0.01 using Dunnett’s test ( Dunn ett, 1964 )] difference between test substance-treated
versus control group animals in the present st udy. In addition, historical control values
for this laboratory were consulted to refi ne data interpretation. The discussion of
individual parameters below refers to gr oup mean values unless stated otherwise

The WIL Research historical control da tabase, version 3.3, for Cr1:CD(SD) rats,
7-50 weeks of age male and female organ we ights, was consulted and referenced as
necessary for the interpretation of data.

**Page 283 of 1107**

## WIL-65501 2-Bromo-3,3,3-Trifluoropropene American Pacific Corporation

-8- 

# 4. R ESULTS


# 4.1. S URVIVAL



## There was no test substance-related effect on survival. All animals survived until

scheduled sacrifice.



# 4.2. G ROSS 

# O BSERVATIONS 

## Review of the gross necropsy observations reve aled no observations that were considered

to be associated with administ ration of the test substance.



# 4.3. O RGAN 

# W EIGHTS



## There was a test substance-related lower (7.1%, p<0.05) final body weight in the
10,000 ppm group males. There we re no test substance-rela ted alterations in organ
weights.

Some organ weight differences were statis tically significant when compared to the
control group but were considered to be a result of a test su bstance-related effect on final
body weight. There was a significantly (p<0.01) higher left epididymis weight relative to
final body weight in the 10,000 ppm group males. Since the change did not correlate to
histologic findings and the mean absolute weight was not affect ed, the change was

considered to be due to the lower mean final body weight. There was a significantly
(p<0.01) higher right testis weight rela tive to body weight in the 10,000 ppm group
males. This change was also a result of a low mean final body weight in this dose group,

and was not test substance-related.

Some statistically significant differences were observed when th e control and test
substance-treated groups were compared, but the changes were not considered test
substance-related. There was a significantly (p<0.01) higher mean lung weight relative to
body weight and a significantly (p<0.01) higher mean lung weight relative to brain
weight in the 175 ppm group males compared to the control group. Because the mean
absolute lung weight was not affected, the relative weights were within the WIL

**Page 284 of 1107**

## WIL-65501 2-Bromo-3,3,3-Trifluoropropene American Pacific Corporation

-9- Research historical control data ranges, and there were no histopathol ogic correlates, the
changes in relative weights were not considered toxicologically significant. There were
significantly (p<0.05 or p<0.01) lo wer pituitary weights (absol ute and relative) in 100,
175, and/or 10,000 ppm group males and females; however, because the changes did not
follow a dose-response profile, were within th e WIL Research historical control range,

and did not correlate to hi stologic findings at 175 or 10,000 ppm, the statistically
significant changes were considered spurious.



# 4.4. H ISTOLOGIC 

# C HANGES



## There were no test substance-related micros copic findings. All histologic changes were
considered to be incidental findings or related to some aspect of experimental
manipulation other than administration of th e test substance. There was no test
substance-related alteration in the prevalence , severity, or histologi c character of those

incidental tissue alterations.

There was no apparent test substance-relate d effect on the counts of primordial and
primary follicles from ovaries in th e control, 175, and 10,000 ppm group females.



# 5. C ONCLUSIONS 

## Whole body exposure of 2-Bromo-3,3,3-Trifl uoropropene atmospheres to male and
female Crl:CD(SD) rats as a daily 6-hour whole-body inhalation exposure (at 50, 100, or
175 ppm) or as a daily 5-minute whole- body exposure (at 10,000 ppm) was associated
with a slightly lower mean final body weight in 10,000 ppm males. There were no test

substance-related effects on survival and th ere were no test subs tance-related gross
pathologic changes, microscopic changes, or organ weight effects. There was no test
substance-related effect on prim ordial/primary follicle counts.

**Page 285 of 1107**

## WIL-65501 2-Bromo-3,3,3-Trifluoropropene American Pacific Corporation

-10- 

# 6. R EFERENCES


## Bolon, B.; Bucci, T.J.; Warbritton, A.R. ; Chen, J.J.; Mattison D. R.; Heindel; J.J. Differential follicle co unts as a screen fo r chemically induced ovarian toxicity in mice: Results from continuous breeding bioassays. Fundamentals of Applied Toxicology 1997, 39 , 1-10.

Bucci, T.J.; Bolon, B.; Warb ritton, A.R.; Chen, J.J.; Heindel, J.J. Influence of sampling on the reprod ucibility of ovarian fo llicle counts in mous e toxicity studies. Reproductive Toxicology 1997, 13 (5), 689-696.

Dunnett, C.W. New tables for mu ltiple comparisons with a control. Biometrics 1964

, 20, 482-491.

Picut, C.A.; Swanson, C.L.; Scully, K. L.; Roseman, V.C. ; Parker, R.F.; Remick, A.K. Ovarian follicle counts using pr oliferating cell nuclear antigen (PCNA) and semi-automated image analysis in rats. Toxicologic Pathology 2008

, 36 (5), 674-679.

**Page 286 of 1107**

# WIL-65501 American Pacific Corporation

WIL-65501 Pathology Report

1 

# Report Submitted By:



# Catherine A. Picut, VMD, 

# DACVP, DABT Date

**Page 287 of 1107**

## WI L

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene

American Pacific Corporation



# APPENDIX **F**

WIL Research Reproductive Historical Control Data [Crl:CD(SD) Rats]

**Page 288 of 1107**Sex: Species: 

## WIL Research Laboratories - Developmental and Reproductive Toxicology

Range of Study Dates: Number of Studies/Data Sets:
Study Type: 10/00 05/11

- /

Strain: Male/Female Rat
Crl:CD(SD) 1-/2-Gen 

## Historical Control Summary of Reproductive Performance

Mean Min/Max Value N S.D. Mean -/+ 2 S.D. Mean -/+ 3 S.D. Total 35 65

Male Copulation Index (%) Male Mating Index (%) 95.5 86.7 100.0 63 4.05 87.40 83.35 // /

87.5 70.0 100.0 63 7.30 72.90 65.60 Male Fertility Index (%)

92.4 70.0 100.0 49 6.72 78.96 72.24 /

/ /

/ /

/ Number of Males in Control Group

Number that did not Deliver Number of Females Selected to Deliver

Number that Delivered

Number with Dystocia Number with Total Litter Loss 96.3 86.7 100.0 65 3.80 88.70 84.90

88.0 70.0 100.0 65 7.25 73.50 66.25 / /

/ /

/ /

92.3 70.0 100.0 48 6.73 78.84 72.11 // / Female Conception Index (%) Female Mating Index (%)

Female Fertility Index (%) Number of Females in Control Group 1837

1903

1868

1624

225

14

2 100.00 100.00

100.00

100.00 100.00

100.00

100.00

100.00

100.00 100.00 100.00 100.00

Number that Died Prior to Delivery 7



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## Reproductive Data (1-/2-Gen Studi es) for Crl:CD(SD) Rats v. 2 .13m4 **Page 1 of 8**

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## WIL Research Laboratories - Developmental and Reproductive Toxicology

Range of Study Dates: Number of Studies/Control Groups:
Study Type: 10/00 05/11

- /

Strain: Female Rat
Crl:CD(SD) 1-/2-Gen 

## Historical Control Summary of Reproductive Performance

Mean Min/Max Value N S.D. Mean -/+ 2 S.D. Mean -/+ 3 S.D. 35 65

14.7 58 0.78 Mean No. of Former Implantation Sites at Weaning

Mean No. of Sites Unaccou nted for at Weaning 0.8 56 0.26 12.6 16.0

0.3 1.4 / / Mean Estrous Cycle Length (days) 4.5 4.0 5.8 65 0.39

3.0 1.8 4.7 65 0.50 /

/ /

Mean Viable Litter Size (PND 0) Mean Gestation Length (days) Mean Pre-Coital Interval (days)

Mean Number of Pups Born

Mean % Females/ Litter Mean % Males/ Litter 22.0 21.5 22.3 65 0.16

13.8 11.7 15.1 65 0.81 / /

13.6 11.6 15.0 65 0.82

50.4 44.2 57.3 65 2.78 / /

49.7 43.4 55.8 65 2.65 /

6.2 2 3.46 3.8 8.7 / Mean Post-Implantation Loss (%/Litter) /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ / 2.00

21.68

12.18

11.96

44.84

44.40

13.14

0.28

0.00 3.72

4.00

22.32

15.42

15.24

55.96

55.00

16.26

1.32

13.12 5.28

1.50

21.52

11.37

11.14

42.06

41.75

12.36

0.02

0.00 3.33

4.50

22.48

16.23

16.06

58.74

57.65

17.04

1.58

16.58 5.67

Mean Primordial Follicle Count of 10 Sections/Dam 121.7 30 36.37 50.4 184.4 / 48.96 / 194.44 12.59 / 230.81



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## WIL Research Laboratories - Developmental and Reproductive Toxicology

Range of Study Dates: Number of Studies/Data Sets:
Study Type: 10/00 05/11

- /

Age Range: Strain:
0 - 21 Days Male/Female Rat
Crl:CD(SD) 1-/2-Gen 

## Historical Control Summary of Pup Survival Indices (%)

Mean Min/Max Value N S.D. Mean -/+ 2 S.D. Mean -/+ 3 S.D. 35 65

PND 0 (Relative to No. Born) / /

PND 0 to PND 1 / /

PND 1 to PND 4 (Before Selection) / /

PND 4 (After Selection) to PND 7 / /

PND 7 to PND 14 / /

PND 14 to PND 21 / /

Birth to PND 4 (Before Selection) / /

PND 4 (After Selection) to PND 21 / / 

### Mean Number of Pups Born


## Survival (%)

98.0 60 1.95 98.0 65 1.34

98.7 65 1.25

98.4 65 1.93

98.9 65 1.29

99.4 65 1.18

99.6 65 0.92

95.3 65 2.63 96.20

94.54

96.32

97.04

97.76

90.04

94.10 95.32

94.95

92.61

95.03

95.86

96.84

87.41

92.15 93.98

91.1 100.0 / 93.3 100.0

94.6 100.0 / /

87.0 99.8

93.5 100.0 / /

93.5 100.0

94.7 100.0 / /

83.8 98.7 / / / 13.8 65 0.81 12.18 11.37 11.7 15.1 / 15.42 16.23

100.00

100.00

100.00 100.00

100.00 100.00

100.00

100.00

100.00

100.00 100.00

100.00

100.00

100.00

100.00

100.00



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## WIL Research Laboratories - Develo pmental and Reproductive Toxicology

Range of Study Dates: Number of Studies/Data Sets: Study Type: 10/00 05/11

- /

Age Range: Strain:
1 - 28 Days Male/Female Rat
Crl:CD(SD) 1-/2-Gen 

## Historical Control Summary of Pup Body Weights (g)

35 65

PND 7

PND 14

PND 21 PND 4 

# Males (g) PND



# Females (g) PND Mean Min/Max Value N S.D. Mean -/+ 2 S.D. Mean -/+ 3 S.D.

Mean Min/Max Value N S.D. Mean -/+ 2 S.D. Mean -/+ 3 S.D.

9.5 65 0.48

14.6 65 1.14 8.5 10.4

11.3 16.7 / / 10.0 9.1 11.0 65 0.49 /

15.4 11.9 17.6 65 1.20

30.9 20.2 36.4 63 3.28 / /

48.6 32.8 57.8 65 4.98

79.3 72.0 88.4 8 4.93 / /

73.4 8 4.58 66.7 82.4 / 29.7 63 3.10 20.3 34.8 /

46.5 65 4.55 32.8 54.9 / / /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ / 9.02

13.00

24.34

38.64

69.44

8.54

12.32

23.50

37.40

64.24 10.98

17.80

37.46

58.56

89.16

10.46

16.88

35.90

55.60

82.56 8.53

11.80

21.06

33.66

64.51

8.06

11.18

20.40

32.85

59.66 11.47

19.00

40.74

63.54

94.09

10.94

18.02

39.00

60.15

87.14 PND 7

PND 14

PND 21 PND 4 PND 11 23.1 22.0 25.3 3 1.88 / / / 19.34 26.86 17.46 28.74

PND 17 32.2 31.9 32.6 2 0.49 / / / 31.22 33.18 30.73 33.67

22.1 3 2.02 20.9 24.4 / / / 18.06 26.14 16.04 28.16 PND 11

30.9 2 0.64 30.5 31.4 / / / 29.62 32.18 28.98 32.82 PND 17 PND 1 7.1 6.7 7.6 65 0.23 / / / 6.64 7.56 6.41 7.79

6.7 6.4 7.1 65 0.22 / / / 6.26 7.14 6.04 7.36 PND 1 PND 28

PND 28



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## WIL Research Laboratories - Developmental and Reproductive Toxicology

Range of Study Dates: Number of Studies/Number Data Sets:
Study Type: 10/00 05/11

- /

Age: Strain:
21 Days Male/Female Rat
Crl:CD(SD) 1-/2-Gen 

## Historical Control Summary of Pup Organ Weights (PND 21)

35 65

Mean Min/Max Value N S.D. Mean -/+ 2 S.D.

Brain (g)

Thymus (g) Spleen (g) Mean -/+ 3 S.D. 

# Males

Females

Brain (g)

Thymus (g) Spleen (g) 1.4556 1.3451 1.5436 50 0.04067

0.2210 0.1471 0.3641 50 0.04129 /

/ /

0.2061 0.1617 0.3541 50 0.03452

1.4063 1.3142 1.5082 50 0.03764 / /

0.2161 0.1401 0.3099 50 0.03828

0.2079 0.1669 0.3483 50 0.03517 / / /

/ /

/ /

/ /

/ /

/ / 0.13842

0.13706

1.33102

0.13954

0.13756 1.37426

0.30358

0.27514

1.48158

0.29266

0.27824 1.53694

0.09713

0.10254

1.29338

0.10126

0.10239 1.33359

0.34487

0.30966

1.51922

0.33094

0.31341 1.57761



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Study Type: 10/00 05/11

- /

Strain: Male/Female Rat
Crl:CD(SD) 1-/2-Gen 

## Historical Control Summary of Developmental Landmarks

Mean Min/Max Value N S.D. Mean -/+ 2 S.D. Mean -/+ 3 S.D. 35 65

Mean Body Weight at Aquisition (g) Mean Female Anogenital Distance (PND1) (mm) Mean Male Anogenital Distance (PND1) (mm)

Mean Day of Balanopreputial Separation

Mean Body Weight at Aquisition (g) Mean Day of Vaginal Patency 4.23 3.5 4.7 12 0.364

2.30 1.8 2.6 12 0.218 /

/ /

45.3 43.0 49.0 31 1.29

229.9 203.7 251.7 31 12.85 / /

33.6 31.3 37.0 31 1.17

111.6 100.0 123.2 31 5.26 / / /

/ /

/ /

/ /

/ /

/ / 1.864

42.72

204.20

31.26

101.08 3.502

2.736

47.88

255.60

35.94

122.12 4.958

1.646

41.43

191.35

30.09

95.82 3.138

2.954

49.17

268.45

37.11

127.38 5.322

Males Females Males

Mean Day of Pinnal Detachment

Males Mean Day of Eye Opening Mean Day of Surface Righting Response

Females

Females

Males Mean Day of Hair Growth

Females Mean Day of Incisor Eruption
Males
Females 5.1 2 0.07

4.1 6 0.12

13.6 4 1.51

10.3 6 0.78 5.1 5.2

4.0 4.3 / /

11.8 15.2

9.3 11.4 / / 5.0 5.0 5.1 2 0.07 /

15.9 6 1.13 15.1 17.8 / 4.0 6 0.08 4.0 4.2 /

16.0 6 1.05 15.1 17.8 /

13.5 4 1.43 11.7 15.0 /

10.2 6 0.70 9.3 11.1 / / /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ / 4.86

4.96

3.86

3.84

13.90

13.64

10.64

10.58

8.74

8.80 5.14

5.24

4.34

4.16

18.10

18.16

16.36

16.62

11.86

11.60 4.79

4.89

3.74

3.76

12.85

12.51

9.21

9.07

7.96

8.10 5.21

5.31

4.46

4.24

19.15

19.29

17.79

18.13

12.64

12.30



### 11-Oct-11 

## Version 2.13m4 N = Count of study means from control groups


## Reproductive Data (1-/2-Gen Studi es) for Crl:CD(SD) Rats v. 2 .13m4 **Page 6 of 8**

**Wed Oct 12 2011 Page 294 of 1107** Sex: Species: 

## WIL Research Laboratories - Developmental and Reproductive Toxicology

Range of Study Dates: Number of Studies/Number Data Sets:
Study Type: 10/00 05/11

- /

Strain: Male/Female Rat
Crl:CD(SD) 1-/2-Gen 

## Historical Control Summary of Male and Female Organ Weights (Necropsy)

35 65

Mean Min/Max Value N S.D. Mean -/+ 2 S.D.

Mean Seminal Vesicle/Coagulating Gland Weight (g)

Mean Right Testis Weight (g) Mean Prostate Weight (g) Mean -/+ 3 S.D.

Mean Left Testis Weight (g)

Mean Left Epididymis Weight (g) Mean Right Epididymis Weight (g)

Mean Left Cauda Epididymis Weight (g) Mean Right Cauda Epididymis Weight (g) 

# Males

Females

Mean Combined Ovary/Oviduct Weight (g) Mean Age of Females at Necropsy (weeks) Mean Age of Males at Necropsy (weeks)

0.3439 58 0.02157

0.3348 58 0.01593 0.2972 0.3939

0.3028 0.3726 / / 24.4 17.0 31.0 63 2.62

2.26 1.88 2.59 51 0.152 /

/ /

1.07 0.85 1.29 61 0.095

1.82 1.67 1.96 59 0.062 / /

1.83 1.70 2.09 59 0.068

0.75 0.66 0.83 59 0.033 / /

0.72 0.63 0.77 59 0.030 /

24.5 63 2.45 17.0 31.0 /

0.1348 31 0.02491 0.0991 0.1705 / /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ / 1.956

0.880

1.696

1.694

0.684

0.660

0.30076

0.30294

19.60

0.08498

19.16

2.564

1.260

1.944

1.966

0.816

0.780

0.38704

0.36666

29.40

0.18462 29.64

1.804

0.785

1.634

1.626

0.651

0.630

0.27919

0.28701

17.15

0.06007

16.54

2.716

1.355

2.006

2.034

0.849

0.810

0.40861

0.38259

31.85

0.20953

32.26

Mean Combined Ovary w/o Oviduct Weight (g) 0.1192 22 0.01057 0.0957 0.1519 / / / 0.09806 0.14034 0.08749 0.15091 Mean Brain Weight (g) 2.15 59 0.036 2.06 2.22 / / / 2.078 2.222 2.042 2.258
Mean Pituitary Weight (g) 0.016 55 0.0013 0.0129 0.0219 / / / 0.0134 0.0186 0.0121 0.0199
Mean Adrenal Weight (g) 0.061 54 0.0040 0.0528 0.0776 / / / 0.0530 0.0690 0.0490 0.0730

Mean Brain Weight (g) 1.98 59 0.033 1.90 2.05 / / / 1.914 2.046 1.881 2.079
Mean Pituitary Weight (g) 0.021 55 0.0220 0.0138 0.1810 / / / 0 0.0650 0 0.0870
Mean Adrenal Weight (g) 0.087 54 0.0867 0.0581 0.7110 / / / 0 0.2604 0 0.3471



### 11-Oct-11 

## Version 2.13m4 N = Count of study means from control groups



## Reproductive Data (1-/2-Gen Studi es) for Crl:CD(SD) Rats v. 2 .13m4 **Page 7 of 8**

**Wed Oct 12 2011 Page 295 of 1107** Sex: Species: 

## WIL Research Laboratories - Developmental and Reproductive Toxicology

Range of Study Dates: Number of Studies/Control Groups:
Study Type: 10/00 05/11

- /

Strain: Male/Female Rat
Crl:CD(SD) 1-/2-Gen 

## Historical Control Summary of Sperm Concentration and Morphology

35 65

Mean Min/Max Value N S.D. Mean -/+ 2 S.D.

Mean Sperm Production Rate Left Epididymis Left Testis Mean -/+ 3 S.D.

Left Cauda Epididymis

Mean Progressive Sperm Motility (%) Mean Sperm Motility (%) Mean Sperm Concentration

(millions/ gram of tissue)

(millions/ gram of tissue/ day)

Misshapen Head w/ Normal Flagellum Head Absent w/ Normal Flagellum Normal Head Separated from Flagellum

Head Absent w/ Abnormal Flagellum

Other Flagellar Defects w/ Normal Head Degenerative Flagellar Defects w/ Normal Head Sperm Morphology Differential Count (%)

Normal

Misshapen Head w/ Abnormal Flagellum 0.3 58 0.28

0.3 58 0.35 0.0 1.6

0.0 2.3 / / 78.5 53.6 96.8 58 8.76

405.0 302.5 548.6 52 56.17 /

/ /

662.3 568.0 738.9 6 62.52

12.9 8.8 15.9 58 1.43 / /

87.3 79.0 93.0 58 2.82

74.5 62.0 81.0 49 3.79 / /

99.4 96.1 99.9 58 0.78 /

0.0 58 0.01 0.0 0.1 / 0.0 58 0.00 0.0 0.0 /

0.0 58 0.00 0.0 0.0 /

0.0 58 0.00 0.0 0.0 /

0.0 58 0.00 0.0 0.0 / /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ / 292.66

537.26

10.04

81.66

66.92

97.84

0.00

0.00

0.00

0.00

0.00

0.00

0.00 60.98

517.34

787.34

15.76

92.94

82.08

100.00

0.86

1.00

0.00

0.00

0.02

0.00

0.00 96.02

236.49

474.74

8.61

78.84

63.13

97.06

0.00

0.00

0.00

0.00

0.00

0.00

0.00 52.22

573.51

849.86

17.19

95.76

85.87

100.00

1.14

1.35

0.00

0.00

0.03

0.00

0.00 104.78



### 11-Oct-11 

## Version 2.13m4 N = Count of study means from control groups



## Reproductive Data (1-/2-Gen Studi es) for Crl:CD(SD) Rats v. 2 .13m4 **Page 8 of 8**

**Wed Oct 12 2011 Page 296 of 1107** Sex: Species: 

## WIL Research Laboratories - Developmental and Reproductive Toxicology

Range of Study Dates: Number of Studies/Control Groups:
Study Type: 12/11 12/12

- /

Strain: Male Rat
Crl:CD(SD) All 

## Historical Control Summary of Sperm Concentration and Morphology (IVOS v. 14)

9 9

Mean Min/Max Value N S.D. Mean -/+ 2 S.D.

Mean Sperm Production Rate Left Epididymis Left Testis Mean -/+ 3 S.D.

Mean Progressive Sperm Motility (%) Mean Sperm Motility (%) Mean Sperm Concentration

(millions/ gram of tissue)

(millions/ gram of tissue/ day) 121.9 80.5 147.9 9 20.08

554.6 307.1 786.5 9 135.60 /

/ /

20.0 13.2 24.2 9 3.28 /

82.6 78.0 90.0 9 3.75

72.0 68.0 79.0 3 6.08 / / /

/ /

/ /

/ /

/ / 283.40

13.44

75.10

59.84 81.74

825.80

26.56

90.10

84.16 162.06

147.80

10.16

71.35

53.76 61.66

961.40

29.84

93.85

90.24 182.14



### 28-Jan-13 

## Version 2.15m6 N = Count of study means from control groups**Page 297 of 1107**

## FINAL **REPORT**

Contents : Volume 2 of 4 Appendix G

Study Title : An Inhalation Reproduction/Developmental Toxicity

Screening Study

of 2

- Bromo

- 3,3,3

- Trifluoropropene in Rats

Laboratory

Project ID : WI L

- 65501

Author: Tammy e L. Edwards, BS

Test Guideline : OECD Guideline 421

Study Completion Date : 21 March 2014

Performing Laboratory : WI L Research 1407 George Road Ashland, OH 44805

- 8946

Sponsor : American Pacific Corporation 3883 Howard Hughes Parkway , Suite 700 Las Vegas, NV 89169

Total Number of Pages: 1 107

**Page 298 of 1107**

## WI L

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene

American Pacific Corporation



# APPENDIX **G**

Individual Animal Data

**Page 299 of 1107**TABLE A1 (F0 MALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

TABLE RANGE: 10-14-13 TO 11-12-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91555 M 0 PPM NORMAL 10-14-13 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91555 M 0 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA 91560 M 0 PPM NORMAL 10-14-13 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91560 M 0 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA 91562 M 0 PPM DISPOSITION 11-11-13 10:18 P SCHEDULED EUTHANASIA 91562 M 0 PPM BODY/INTEGUMENT 10-14-13 6:45 1 HAIR LOSS RIGHT FORELIMB 10-14-13 6:45 1 HAIR LOSS LEFT FORELIMB 10-21-13 7:16 1 HAIR LOSS RIGHT FORELIMB 10-21-13 7:16 1 HAIR LOSS LEFT FORELIMB 10-27-13 6:39 1 HAIR LOSS RIGHT FORELIMB 10-27-13 6:39 1 HAIR LOSS LEFT FORELIMB 11-04-13 6:30 1 HAIR LOSS RIGHT FORELIMB 11-04-13 6:30 1 HAIR LOSS LEFT FORELIMB 11-11-13 7:36 2 HAIR LOSS LEFT FORELIMB 11-11-13 7:36 2 HAIR LOSS RIGHT FORELIMB 91563 M 0 PPM NORMAL 10-14-13 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91563 M 0 PPM DISPOSITION 11-11-13 10:19 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 300 of 1107**TABLE A1 (F0 MALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

TABLE RANGE: 10-14-13 TO 11-12-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91564 M 0 PPM NORMAL 10-14-13 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91564 M 0 PPM DISPOSITION 11-12-13 10:34 P SCHEDULED EUTHANASIA 91567 M 0 PPM NORMAL 10-14-13 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91567 M 0 PPM DISPOSITION 11-11-13 10:18 P SCHEDULED EUTHANASIA 91579 M 0 PPM NORMAL 10-14-13 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91579 M 0 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA 91586 M 0 PPM NORMAL 10-14-13 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91586 M 0 PPM DISPOSITION 11-11-13 10:19 P SCHEDULED EUTHANASIA 91591 M 0 PPM NORMAL 10-14-13 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91591 M 0 PPM DISPOSITION 11-11-13 10:20 P SCHEDULED EUTHANASIA 91591 M 0 PPM BODY/INTEGUMENT 10-21-13 7:18 1 HAIR LOSS RIGHT FORELIMB 10-21-13 7:18 1 HAIR LOSS LEFT FORELIMB 10-27-13 6:40 1 HAIR LOSS RIGHT FORELIMB

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 301 of 1107**TABLE A1 (F0 MALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

TABLE RANGE: 10-14-13 TO 11-12-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91591 M 0 PPM BODY/INTEGUMENT 10-27-13 6:40 1 HAIR LOSS LEFT FORELIMB 11-04-13 6:32 1 HAIR LOSS RIGHT FORELIMB 11-04-13 6:32 1 HAIR LOSS LEFT FORELIMB 11-11-13 7:39 1 HAIR LOSS RIGHT FORELIMB 11-11-13 7:39 1 HAIR LOSS LEFT FORELIMB 91592 M 0 PPM NORMAL 10-14-13 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91592 M 0 PPM DISPOSITION 11-12-13 10:34 P SCHEDULED EUTHANASIA 91609 M 0 PPM NORMAL 10-14-13 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91609 M 0 PPM DISPOSITION 11-12-13 10:34 P SCHEDULED EUTHANASIA 91615 M 0 PPM NORMAL 10-14-13 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91615 M 0 PPM DISPOSITION 11-11-13 10:19 P SCHEDULED EUTHANASIA 91556 M 50 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA 91556 M 50 PPM BODY/INTEGUMENT 10-14-13 6:50 1 HAIR LOSS RIGHT FORELIMB 10-14-13 6:50 1 HAIR LOSS LEFT FORELIMB 10-21-13 7:21 1 HAIR LOSS RIGHT FORELIMB 10-21-13 7:21 1 HAIR LOSS LEFT FORELIMB 10-27-13 6:41 1 HAIR LOSS RIGHT FORELIMB

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 302 of 1107**TABLE A1 (F0 MALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

TABLE RANGE: 10-14-13 TO 11-12-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91556 M 50 PPM BODY/INTEGUMENT 10-27-13 6:41 1 HAIR LOSS LEFT FORELIMB 11-04-13 6:33 1 HAIR LOSS RIGHT FORELIMB 11-04-13 6:33 1 HAIR LOSS LEFT FORELIMB 11-11-13 7:42 2 HAIR LOSS RIGHT FORELIMB 11-11-13 7:42 2 HAIR LOSS LEFT FORELIMB 91559 M 50 PPM NORMAL 10-14-13 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91559 M 50 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA 91561 M 50 PPM NORMAL 10-14-13 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91561 M 50 PPM DISPOSITION 11-11-13 10:20 P SCHEDULED EUTHANASIA 91566 M 50 PPM NORMAL 10-14-13 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91566 M 50 PPM DISPOSITION 11-11-13 10:19 P SCHEDULED EUTHANASIA 91576 M 50 PPM NORMAL 10-14-13 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91576 M 50 PPM DISPOSITION 11-11-13 10:19 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 303 of 1107**TABLE A1 (F0 MALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

TABLE RANGE: 10-14-13 TO 11-12-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91582 M 50 PPM NORMAL 10-14-13 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91582 M 50 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA 91582 M 50 PPM BODY/INTEGUMENT 10-21-13 7:24 1 HAIR LOSS RIGHT FORELIMB 10-21-13 7:24 1 HAIR LOSS LEFT FORELIMB 91585 M 50 PPM NORMAL 10-14-13 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91585 M 50 PPM DISPOSITION 11-12-13 10:34 P SCHEDULED EUTHANASIA 91585 M 50 PPM BODY/INTEGUMENT 11-11-13 7:45 1 HAIR LOSS RIGHT FORELIMB 91589 M 50 PPM NORMAL 10-14-13 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91589 M 50 PPM DISPOSITION 11-11-13 10:19 P SCHEDULED EUTHANASIA 91589 M 50 PPM BODY/INTEGUMENT 10-21-13 7:25 1 HAIR LOSS RIGHT FORELIMB 10-21-13 7:25 1 HAIR LOSS LEFT FORELIMB 10-27-13 6:43 1 HAIR LOSS RIGHT FORELIMB 10-27-13 6:43 1 HAIR LOSS LEFT FORELIMB 11-04-13 6:35 1 HAIR LOSS RIGHT FORELIMB 11-04-13 6:35 1 HAIR LOSS LEFT FORELIMB 11-11-13 7:46 3 HAIR LOSS RIGHT FORELIMB 11-11-13 7:46 3 HAIR LOSS LEFT FORELIMB 91593 M 50 PPM NORMAL 10-14-13 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91593 M 50 PPM DISPOSITION 11-11-13 10:20 P SCHEDULED EUTHANASIA 91593 M 50 PPM BODY/INTEGUMENT 10-21-13 7:26 2 HAIR LOSS LEFT INGUINAL AREA 10-27-13 6:43 1 HAIR LOSS LEFT INGUINAL AREA 11-04-13 6:35 1 HAIR LOSS LEFT INGUINAL AREA 11-11-13 7:47 2 HAIR LOSS LEFT FORELIMB

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 304 of 1107**TABLE A1 (F0 MALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

TABLE RANGE: 10-14-13 TO 11-12-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91594 M 50 PPM NORMAL 10-14-13 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91594 M 50 PPM DISPOSITION 11-11-13 10:18 P SCHEDULED EUTHANASIA 91595 M 50 PPM NORMAL 10-14-13 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91595 M 50 PPM DISPOSITION 11-12-13 10:34 P SCHEDULED EUTHANASIA 91602 M 50 PPM NORMAL 10-14-13 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91602 M 50 PPM DISPOSITION 11-12-13 10:34 P SCHEDULED EUTHANASIA 91569 M 100 PPM NORMAL 10-14-13 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91569 M 100 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA 91569 M 100 PPM BODY/INTEGUMENT 10-21-13 7:28 1 HAIR LOSS RIGHT FORELIMB 10-21-13 7:28 1 HAIR LOSS LEFT FORELIMB 10-27-13 6:45 1 HAIR LOSS RIGHT FORELIMB 10-27-13 6:45 1 HAIR LOSS LEFT FORELIMB 11-04-13 6:38 1 HAIR LOSS RIGHT FORELIMB 11-04-13 6:38 1 HAIR LOSS LEFT FORELIMB 11-11-13 7:48 2 HAIR LOSS RIGHT FORELIMB 11-11-13 7:48 2 HAIR LOSS LEFT FORELIMB 91573 M 100 PPM DISPOSITION 11-11-13 10:19 P SCHEDULED EUTHANASIA

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TABLE RANGE: 10-14-13 TO 11-12-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91573 M 100 PPM BODY/INTEGUMENT 10-14-13 6:57 1 HAIR LOSS RIGHT FORELIMB 10-14-13 6:57 1 HAIR LOSS LEFT FORELIMB 10-21-13 7:29 1 HAIR LOSS RIGHT FORELIMB 10-21-13 7:29 1 HAIR LOSS LEFT FORELIMB 11-11-13 7:49 2 HAIR LOSS RIGHT FORELIMB 11-11-13 7:49 2 HAIR LOSS LEFT FORELIMB 91573 M 100 PPM EYES/EARS/NOSE 10-27-13 6:46 1 DRIED RED MATERIAL AROUND LEFT EYE 11-04-13 6:39 1 DRIED RED MATERIAL AROUND LEFT EYE 11-04-13 6:39 1 DRIED RED MATERIAL AROUND RIGHT EYE 11-11-13 7:49 2 DRIED RED MATERIAL AROUND LEFT EYE 11-11-13 7:49 2 DRIED RED MATERIAL AROUND RIGHT EYE 91573 M 100 PPM ORAL/DENTAL 10-27-13 6:46 P UPPER INCISORS MALALIGNED 10-27-13 6:46 P TEETH LONG; TRIMMED 11-04-13 6:39 P UPPER INCISORS MALALIGNED 11-04-13 6:39 P TEETH LONG; TRIMMED 11-11-13 7:49 P UPPER INCISORS MALALIGNED 91577 M 100 PPM NORMAL 10-14-13 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91577 M 100 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA 91581 M 100 PPM NORMAL 10-14-13 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91581 M 100 PPM DISPOSITION 11-11-13 10:20 P SCHEDULED EUTHANASIA 91583 M 100 PPM NORMAL 10-14-13 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-12-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91583 M 100 PPM DISPOSITION 11-11-13 10:18 P SCHEDULED EUTHANASIA 91583 M 100 PPM BODY/INTEGUMENT 10-21-13 7:30 1 HAIR LOSS RIGHT FORELIMB 10-21-13 7:30 1 HAIR LOSS LEFT FORELIMB 10-27-13 6:47 1 HAIR LOSS RIGHT FORELIMB 10-27-13 6:47 1 HAIR LOSS LEFT FORELIMB 11-04-13 6:40 1 HAIR LOSS RIGHT FORELIMB 11-04-13 6:40 1 HAIR LOSS LEFT FORELIMB 11-11-13 7:51 1 HAIR LOSS RIGHT FORELIMB 11-11-13 7:51 2 HAIR LOSS LEFT FORELIMB 91588 M 100 PPM NORMAL 10-14-13 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91588 M 100 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA 91590 M 100 PPM NORMAL 10-14-13 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91590 M 100 PPM DISPOSITION 11-11-13 10:18 P SCHEDULED EUTHANASIA 91598 M 100 PPM NORMAL 10-14-13 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91598 M 100 PPM DISPOSITION 11-12-13 10:34 P SCHEDULED EUTHANASIA 91599 M 100 PPM NORMAL 10-14-13 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-12-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91599 M 100 PPM NORMAL 10-27-13 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91599 M 100 PPM DISPOSITION 11-11-13 10:18 P SCHEDULED EUTHANASIA 91608 M 100 PPM NORMAL 10-14-13 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91608 M 100 PPM DISPOSITION 11-12-13 10:34 P SCHEDULED EUTHANASIA 91611 M 100 PPM NORMAL 10-14-13 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91611 M 100 PPM DISPOSITION 11-11-13 10:19 P SCHEDULED EUTHANASIA 91616 M 100 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA 91616 M 100 PPM BODY/INTEGUMENT 10-14-13 7:02 1 HAIR LOSS RIGHT FORELIMB 10-14-13 7:02 1 HAIR LOSS LEFT FORELIMB 10-21-13 7:33 1 HAIR LOSS RIGHT FORELIMB 10-21-13 7:33 1 HAIR LOSS LEFT FORELIMB 10-27-13 6:49 1 HAIR LOSS RIGHT FORELIMB 10-27-13 6:49 1 HAIR LOSS LEFT FORELIMB 11-04-13 6:42 1 HAIR LOSS RIGHT FORELIMB 11-04-13 6:42 1 HAIR LOSS LEFT FORELIMB 11-11-13 7:54 3 HAIR LOSS RIGHT FORELIMB 11-11-13 7:54 3 HAIR LOSS LEFT FORELIMB 91565 M 175 PPM NORMAL 10-14-13 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-12-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91565 M 175 PPM NORMAL 10-27-13 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91565 M 175 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA 91568 M 175 PPM NORMAL 10-14-13 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91568 M 175 PPM DISPOSITION 11-11-13 10:18 P SCHEDULED EUTHANASIA 91570 M 175 PPM NORMAL 10-14-13 7:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91570 M 175 PPM DISPOSITION 11-11-13 10:19 P SCHEDULED EUTHANASIA 91572 M 175 PPM NORMAL 10-14-13 7:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91572 M 175 PPM DISPOSITION 11-12-13 10:34 P SCHEDULED EUTHANASIA 91572 M 175 PPM BODY/INTEGUMENT 10-21-13 7:41 2 HAIR LOSS RIGHT FORELIMB 10-21-13 7:41 2 HAIR LOSS LEFT FORELIMB 10-27-13 6:50 1 HAIR LOSS RIGHT FORELIMB 10-27-13 6:50 1 HAIR LOSS LEFT FORELIMB 11-04-13 6:43 1 HAIR LOSS RIGHT FORELIMB 11-04-13 6:43 1 HAIR LOSS LEFT FORELIMB 11-11-13 7:56 3 HAIR LOSS RIGHT FORELIMB 11-11-13 7:56 3 HAIR LOSS LEFT FORELIMB 91580 M 175 PPM NORMAL 10-14-13 7:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-12-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91580 M 175 PPM NORMAL 11-04-13 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91580 M 175 PPM DISPOSITION 11-12-13 10:34 P SCHEDULED EUTHANASIA 91584 M 175 PPM NORMAL 10-14-13 7:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91584 M 175 PPM DISPOSITION 11-11-13 10:20 P SCHEDULED EUTHANASIA 91587 M 175 PPM DISPOSITION 11-11-13 10:18 P SCHEDULED EUTHANASIA 91587 M 175 PPM BODY/INTEGUMENT 10-14-13 7:06 1 HAIR LOSS LEFT FORELIMB 10-21-13 7:42 1 HAIR LOSS RIGHT FORELIMB 10-21-13 7:42 1 HAIR LOSS LEFT FORELIMB 10-27-13 6:50 1 HAIR LOSS RIGHT FORELIMB 10-27-13 6:50 1 HAIR LOSS LEFT FORELIMB 11-04-13 6:44 1 HAIR LOSS RIGHT FORELIMB 11-04-13 6:44 1 HAIR LOSS LEFT FORELIMB 11-11-13 7:58 3 HAIR LOSS RIGHT FORELIMB 11-11-13 7:58 3 HAIR LOSS LEFT FORELIMB 91597 M 175 PPM NORMAL 10-14-13 7:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91597 M 175 PPM DISPOSITION 11-12-13 10:34 P SCHEDULED EUTHANASIA 91597 M 175 PPM BODY/INTEGUMENT 10-21-13 7:43 1 HAIR LOSS LEFT FORELIMB 91601 M 175 PPM NORMAL 10-14-13 7:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-12-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91601 M 175 PPM DISPOSITION 11-11-13 10:19 P SCHEDULED EUTHANASIA 91601 M 175 PPM BODY/INTEGUMENT 11-11-13 7:59 1 HAIR LOSS RIGHT FORELIMB 11-11-13 7:59 1 HAIR LOSS LEFT FORELIMB 91607 M 175 PPM NORMAL 10-14-13 7:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91607 M 175 PPM DISPOSITION 11-11-13 10:18 P SCHEDULED EUTHANASIA 91607 M 175 PPM BODY/INTEGUMENT 10-21-13 7:44 1 HAIR LOSS RIGHT FORELIMB 10-21-13 7:44 1 HAIR LOSS LEFT FORELIMB 10-27-13 6:51 1 HAIR LOSS RIGHT FORELIMB 10-27-13 6:51 1 HAIR LOSS LEFT FORELIMB 11-04-13 6:45 1 HAIR LOSS RIGHT FORELIMB 11-04-13 6:45 1 HAIR LOSS LEFT FORELIMB 11-11-13 7:59 3 HAIR LOSS RIGHT FORELIMB 11-11-13 7:59 3 HAIR LOSS LEFT FORELIMB 91613 M 175 PPM NORMAL 10-14-13 7:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91613 M 175 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA 91614 M 175 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA 91614 M 175 PPM BODY/INTEGUMENT 10-14-13 7:09 2 HAIR LOSS RIGHT FORELIMB 10-14-13 7:09 2 HAIR LOSS LEFT FORELIMB 10-21-13 7:45 2 HAIR LOSS RIGHT FORELIMB 10-21-13 7:45 2 HAIR LOSS LEFT FORELIMB 10-27-13 6:52 2 HAIR LOSS RIGHT FORELIMB 10-27-13 6:52 2 HAIR LOSS LEFT FORELIMB 11-04-13 6:46 2 HAIR LOSS RIGHT FORELIMB 11-04-13 6:46 2 HAIR LOSS LEFT FORELIMB 11-11-13 8:00 3 HAIR LOSS RIGHT FORELIMB

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TABLE RANGE: 10-14-13 TO 11-12-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91614 M 175 PPM BODY/INTEGUMENT 11-11-13 8:00 3 HAIR LOSS LEFT FORELIMB 91554 M 10000 PPM NORMAL 10-14-13 7:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91554 M 10000 PPM DISPOSITION 11-11-13 10:20 P SCHEDULED EUTHANASIA 91557 M 10000 PPM NORMAL 10-14-13 7:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91557 M 10000 PPM DISPOSITION 11-11-13 10:19 P SCHEDULED EUTHANASIA 91558 M 10000 PPM NORMAL 10-14-13 7:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91558 M 10000 PPM DISPOSITION 11-11-13 10:18 P SCHEDULED EUTHANASIA 91571 M 10000 PPM NORMAL 10-14-13 7:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91571 M 10000 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA 91575 M 10000 PPM NORMAL 10-14-13 7:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-12-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91575 M 10000 PPM NORMAL 11-11-13 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91575 M 10000 PPM DISPOSITION 11-11-13 10:19 P SCHEDULED EUTHANASIA 91600 M 10000 PPM NORMAL 10-14-13 7:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 8:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91600 M 10000 PPM DISPOSITION 11-12-13 10:34 P SCHEDULED EUTHANASIA 91603 M 10000 PPM NORMAL 10-14-13 7:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 8:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91603 M 10000 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA 91604 M 10000 PPM NORMAL 10-14-13 7:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91604 M 10000 PPM DISPOSITION 11-11-13 10:18 P SCHEDULED EUTHANASIA 91604 M 10000 PPM BODY/INTEGUMENT 11-11-13 8:03 1 HAIR LOSS RIGHT FORELIMB 91605 M 10000 PPM NORMAL 10-14-13 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91605 M 10000 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA 91612 M 10000 PPM NORMAL 10-14-13 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-12-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91612 M 10000 PPM NORMAL 11-04-13 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91612 M 10000 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA 91618 M 10000 PPM DISPOSITION 11-12-13 10:34 P SCHEDULED EUTHANASIA 91618 M 10000 PPM BODY/INTEGUMENT 10-14-13 7:15 1 HAIR LOSS RIGHT FORELIMB 10-14-13 7:15 1 HAIR LOSS LEFT FORELIMB 10-21-13 7:50 1 HAIR LOSS RIGHT FORELIMB 10-21-13 7:50 1 HAIR LOSS LEFT FORELIMB 10-27-13 6:54 1 HAIR LOSS RIGHT FORELIMB 10-27-13 6:54 1 HAIR LOSS LEFT FORELIMB 11-04-13 6:49 1 HAIR LOSS RIGHT FORELIMB 11-04-13 6:49 1 HAIR LOSS LEFT FORELIMB 11-11-13 8:04 2 HAIR LOSS RIGHT FORELIMB 11-11-13 8:04 2 HAIR LOSS LEFT FORELIMB 91619 M 10000 PPM NORMAL 10-14-13 7:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 8:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91619 M 10000 PPM DISPOSITION 11-11-13 10:19 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PCRDv4.18 11/25/2013**Page 314 of 1107**TABLE A2 (F0 MALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91554 M 10000 PPM NORMAL 10-22-13 12:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 13:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 11:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91554 M 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY 91554 M 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION 91554 M 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT 10-14-13 13:26 P LACRIMATION 10-17-13 11:51 1 WET RED MATERIAL AROUND NOSE 91554 M 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION 10-15-13 12:23 1 SALIVATION 10-16-13 12:15 1 SALIVATION 10-17-13 11:51 1 SALIVATION 10-18-13 11:45 1 SALIVATION 10-19-13 11:22 1 SALIVATION 10-20-13 11:18 1 SALIVATION 10-21-13 12:32 2 SALIVATION 10-23-13 11:43 1 SALIVATION 10-23-13 11:43 2 WET CLEAR MATERIAL AROUND MOUTH 10-25-13 14:10 1 SALIVATION 10-26-13 11:52 1 SALIVATION 10-28-13 12:54 1 WET CLEAR MATERIAL AROUND MOUTH 10-28-13 12:54 2 SALIVATION 10-29-13 12:27 2 WET CLEAR MATERIAL AROUND MOUTH 10-29-13 12:27 2 SALIVATION 10-30-13 12:26 1 WET CLEAR MATERIAL AROUND MOUTH 10-31-13 11:50 2 SALIVATION 11-01-13 11:36 2 WET CLEAR MATERIAL AROUND MOUTH 11-01-13 11:36 2 SALIVATION 11-02-13 11:34 3 WET CLEAR MATERIAL AROUND MOUTH

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TABLE RANGE: 10-14-13 TO 11-11-13

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----------------------------------------------------------------------------------------------------------------------------------- 91554 M 10000 PPM ORAL/DENTAL 11-02-13 11:34 2 SALIVATION 11-03-13 11:15 2 SALIVATION 11-04-13 12:05 1 WET CLEAR MATERIAL AROUND MOUTH 11-04-13 12:05 2 SALIVATION 11-05-13 11:21 1 WET CLEAR MATERIAL AROUND MOUTH 11-05-13 11:21 1 SALIVATION 11-06-13 11:43 2 WET CLEAR MATERIAL AROUND MOUTH 11-06-13 11:43 2 SALIVATION 11-07-13 11:57 2 WET CLEAR MATERIAL AROUND MOUTH 11-07-13 11:57 2 SALIVATION 11-08-13 13:01 1 WET CLEAR MATERIAL AROUND MOUTH 11-08-13 13:01 1 SALIVATION 11-09-13 11:52 1 SALIVATION 11-10-13 13:11 1 SALIVATION 91557 M 10000 PPM NORMAL 10-17-13 11:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 11:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 11:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 12:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 13:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 11:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91557 M 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY 91557 M 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION 91557 M 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT 10-14-13 13:26 P LACRIMATION 10-26-13 11:52 1 DRIED RED MATERIAL AROUND LEFT EYE 11-01-13 11:36 2 WET RED MATERIAL AROUND NOSE 91557 M 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION 10-15-13 12:23 2 WET CLEAR MATERIAL AROUND MOUTH 10-16-13 12:14 1 SALIVATION

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TABLE RANGE: 10-14-13 TO 11-11-13

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----------------------------------------------------------------------------------------------------------------------------------- 91557 M 10000 PPM ORAL/DENTAL 10-19-13 11:22 1 SALIVATION 10-21-13 12:32 1 SALIVATION 10-23-13 11:42 1 SALIVATION 10-23-13 11:42 1 WET CLEAR MATERIAL AROUND MOUTH 10-25-13 14:10 1 SALIVATION 10-27-13 11:46 1 SALIVATION 10-28-13 12:54 3 WET CLEAR MATERIAL AROUND MOUTH 10-29-13 12:27 2 WET CLEAR MATERIAL AROUND MOUTH 10-29-13 12:27 2 SALIVATION 10-30-13 12:26 1 SALIVATION 10-31-13 11:50 2 WET CLEAR MATERIAL AROUND MOUTH 10-31-13 11:50 1 SALIVATION 11-01-13 11:37 2 WET CLEAR MATERIAL AROUND MOUTH 11-01-13 11:37 2 SALIVATION 11-02-13 11:34 3 WET CLEAR MATERIAL AROUND MOUTH 11-02-13 11:34 3 SALIVATION 11-03-13 11:15 3 WET CLEAR MATERIAL AROUND MOUTH 11-03-13 11:15 3 SALIVATION 11-04-13 12:05 3 WET CLEAR MATERIAL AROUND MOUTH 11-04-13 12:05 3 SALIVATION 11-05-13 11:22 3 WET CLEAR MATERIAL AROUND MOUTH 11-05-13 11:22 3 SALIVATION 11-07-13 11:58 3 WET CLEAR MATERIAL AROUND MOUTH 11-07-13 11:58 3 SALIVATION 11-08-13 13:02 3 WET CLEAR MATERIAL AROUND MOUTH 11-08-13 13:02 3 SALIVATION 11-09-13 11:52 2 SALIVATION 11-10-13 13:11 1 SALIVATION 91558 M 10000 PPM NORMAL 10-25-13 14:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91558 M 10000 PPM NORMAL 10-26-13 11:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91558 M 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY 91558 M 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION 91558 M 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT 10-14-13 13:26 P LACRIMATION 10-17-13 11:56 1 WET RED MATERIAL AROUND NOSE 91558 M 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION 10-15-13 12:19 1 SALIVATION 10-16-13 12:12 2 SALIVATION 10-17-13 11:56 1 SALIVATION 10-18-13 11:45 1 SALIVATION 10-18-13 11:45 2 WET CLEAR MATERIAL AROUND MOUTH 10-19-13 11:24 1 SALIVATION 10-20-13 11:20 1 SALIVATION 10-21-13 12:36 1 SALIVATION 10-22-13 12:03 1 SALIVATION 10-23-13 11:47 2 SALIVATION 10-24-13 13:40 1 SALIVATION 10-28-13 12:55 3 WET CLEAR MATERIAL AROUND MOUTH 10-28-13 12:55 3 SALIVATION 10-29-13 12:28 3 WET CLEAR MATERIAL AROUND MOUTH 10-29-13 12:28 3 SALIVATION 10-30-13 12:27 1 SALIVATION 10-31-13 11:51 2 WET CLEAR MATERIAL AROUND MOUTH 10-31-13 11:51 1 SALIVATION 11-01-13 11:38 3 WET CLEAR MATERIAL AROUND MOUTH 11-01-13 11:38 3 SALIVATION 11-02-13 11:36 3 WET CLEAR MATERIAL AROUND MOUTH

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91558 M 10000 PPM ORAL/DENTAL 11-02-13 11:36 3 SALIVATION 11-03-13 11:16 2 WET CLEAR MATERIAL AROUND MOUTH 11-03-13 11:16 1 SALIVATION 11-04-13 12:06 3 WET CLEAR MATERIAL AROUND MOUTH 11-04-13 12:06 3 SALIVATION 11-05-13 11:23 2 WET CLEAR MATERIAL AROUND MOUTH 11-05-13 11:23 1 SALIVATION 11-06-13 11:44 1 WET CLEAR MATERIAL AROUND MOUTH 11-06-13 11:44 1 SALIVATION 11-07-13 11:59 3 WET CLEAR MATERIAL AROUND MOUTH 11-07-13 11:59 3 SALIVATION 11-08-13 13:03 2 WET CLEAR MATERIAL AROUND MOUTH 11-08-13 13:03 2 SALIVATION 11-09-13 11:55 1 SALIVATION 11-10-13 13:12 2 SALIVATION 91571 M 10000 PPM NORMAL 10-16-13 12:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 11:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 13:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91571 M 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY 91571 M 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION 91571 M 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT 10-14-13 13:26 P LACRIMATION 91571 M 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION 10-15-13 12:24 1 SALIVATION 10-17-13 11:50 1 WET CLEAR MATERIAL AROUND MOUTH 10-19-13 11:21 1 SALIVATION 10-20-13 11:18 1 SALIVATION 10-21-13 12:33 1 SALIVATION 10-22-13 12:02 1 SALIVATION

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TABLE RANGE: 10-14-13 TO 11-11-13

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----------------------------------------------------------------------------------------------------------------------------------- 91571 M 10000 PPM ORAL/DENTAL 10-23-13 11:44 1 SALIVATION 10-25-13 14:10 1 SALIVATION 10-26-13 11:53 1 SALIVATION 10-27-13 11:47 1 SALIVATION 10-28-13 12:53 2 WET CLEAR MATERIAL AROUND MOUTH 10-28-13 12:53 2 SALIVATION 10-29-13 12:26 2 SALIVATION 10-29-13 12:26 2 WET CLEAR MATERIAL AROUND MOUTH 10-30-13 12:26 1 SALIVATION 10-31-13 11:49 3 WET CLEAR MATERIAL AROUND MOUTH 10-31-13 11:49 3 SALIVATION 11-01-13 11:36 2 WET CLEAR MATERIAL AROUND MOUTH 11-01-13 11:36 2 SALIVATION 11-02-13 11:33 3 WET CLEAR MATERIAL AROUND MOUTH 11-02-13 11:33 3 SALIVATION 11-03-13 11:14 3 WET CLEAR MATERIAL AROUND MOUTH 11-03-13 11:14 3 SALIVATION 11-04-13 12:04 1 WET CLEAR MATERIAL AROUND MOUTH 11-04-13 12:04 1 SALIVATION 11-05-13 11:21 1 WET CLEAR MATERIAL AROUND MOUTH 11-05-13 11:21 1 SALIVATION 11-06-13 11:42 2 WET CLEAR MATERIAL AROUND MOUTH 11-06-13 11:42 2 SALIVATION 11-07-13 11:57 3 WET CLEAR MATERIAL AROUND MOUTH 11-07-13 11:57 2 SALIVATION 11-08-13 13:01 3 WET CLEAR MATERIAL AROUND MOUTH 11-08-13 13:01 3 SALIVATION 11-09-13 11:51 1 SALIVATION 11-10-13 13:11 1 SALIVATION

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91571 M 10000 PPM ORAL/DENTAL 11-11-13 12:43 2 WET CLEAR MATERIAL AROUND MOUTH 11-11-13 12:43 2 SALIVATION 91575 M 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY 91575 M 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION 91575 M 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT 10-14-13 13:26 P LACRIMATION 91575 M 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION 10-15-13 12:21 1 WET CLEAR MATERIAL AROUND MOUTH 10-16-13 12:13 1 WET RED MATERIAL AROUND MOUTH 10-17-13 11:53 1 SALIVATION 10-18-13 11:47 1 WET RED MATERIAL AROUND MOUTH 10-19-13 11:23 1 WET RED MATERIAL AROUND MOUTH 10-20-13 11:16 1 SALIVATION 10-21-13 12:31 2 SALIVATION 10-22-13 12:00 1 SALIVATION 10-23-13 11:41 2 SALIVATION 10-23-13 11:41 1 WET CLEAR MATERIAL AROUND MOUTH 10-24-13 13:38 1 SALIVATION 10-25-13 14:09 1 SALIVATION 10-26-13 11:51 1 SALIVATION 10-27-13 11:46 1 SALIVATION 10-28-13 12:54 3 WET CLEAR MATERIAL AROUND MOUTH 10-28-13 12:55 2 SALIVATION 10-29-13 12:28 3 WET CLEAR MATERIAL AROUND MOUTH 10-29-13 12:28 3 SALIVATION 10-30-13 12:25 1 SALIVATION 10-31-13 11:51 2 WET CLEAR MATERIAL AROUND MOUTH 10-31-13 11:51 1 SALIVATION 11-01-13 11:37 2 WET CLEAR MATERIAL AROUND MOUTH

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91575 M 10000 PPM ORAL/DENTAL 11-01-13 11:37 1 SALIVATION 11-02-13 11:35 2 WET CLEAR MATERIAL AROUND MOUTH 11-02-13 11:35 1 SALIVATION 11-03-13 11:15 3 WET CLEAR MATERIAL AROUND MOUTH 11-03-13 11:15 3 SALIVATION 11-04-13 12:05 3 WET CLEAR MATERIAL AROUND MOUTH 11-04-13 12:05 3 SALIVATION 11-05-13 11:22 3 WET CLEAR MATERIAL AROUND MOUTH 11-05-13 11:22 3 SALIVATION 11-06-13 11:43 3 WET CLEAR MATERIAL AROUND MOUTH 11-06-13 11:43 2 SALIVATION 11-07-13 11:58 3 WET CLEAR MATERIAL AROUND MOUTH 11-07-13 11:58 3 SALIVATION 11-08-13 13:02 3 WET CLEAR MATERIAL AROUND MOUTH 11-08-13 13:02 3 SALIVATION 11-09-13 11:53 1 SALIVATION 11-10-13 13:12 2 SALIVATION 91600 M 10000 PPM NORMAL 10-24-13 13:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 11:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91600 M 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY 91600 M 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION 91600 M 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT 10-14-13 13:26 P LACRIMATION 91600 M 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION 10-15-13 12:24 1 SALIVATION 10-16-13 12:15 1 SALIVATION 10-17-13 11:52 1 SALIVATION 10-18-13 11:44 2 SALIVATION 10-18-13 11:44 2 WET CLEAR MATERIAL AROUND MOUTH

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91600 M 10000 PPM ORAL/DENTAL 10-19-13 11:21 1 SALIVATION 10-19-13 11:21 1 WET CLEAR MATERIAL AROUND MOUTH 10-20-13 11:18 2 SALIVATION 10-21-13 12:33 2 SALIVATION 10-22-13 12:01 2 SALIVATION 10-23-13 11:44 1 SALIVATION 10-23-13 11:44 1 WET CLEAR MATERIAL AROUND MOUTH 10-25-13 14:10 1 SALIVATION 10-26-13 11:53 1 SALIVATION 10-28-13 12:53 3 WET CLEAR MATERIAL AROUND MOUTH 10-29-13 12:26 3 WET CLEAR MATERIAL AROUND MOUTH 10-29-13 12:26 3 SALIVATION 10-30-13 12:26 1 WET CLEAR MATERIAL AROUND MOUTH 10-31-13 11:49 3 WET CLEAR MATERIAL AROUND MOUTH 10-31-13 11:49 3 SALIVATION 11-01-13 11:36 2 WET CLEAR MATERIAL AROUND MOUTH 11-01-13 11:36 2 SALIVATION 11-02-13 11:34 3 WET CLEAR MATERIAL AROUND MOUTH 11-02-13 11:34 2 SALIVATION 11-03-13 11:14 3 WET CLEAR MATERIAL AROUND MOUTH 11-03-13 11:14 3 SALIVATION 11-04-13 12:04 2 WET CLEAR MATERIAL AROUND MOUTH 11-04-13 12:04 2 SALIVATION 11-05-13 11:21 3 WET CLEAR MATERIAL AROUND MOUTH 11-05-13 11:21 3 SALIVATION 11-06-13 11:43 2 WET CLEAR MATERIAL AROUND MOUTH 11-06-13 11:43 2 SALIVATION 11-07-13 11:57 2 WET CLEAR MATERIAL AROUND MOUTH 11-07-13 11:57 2 SALIVATION

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TABLE RANGE: 10-14-13 TO 11-11-13

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----------------------------------------------------------------------------------------------------------------------------------- 91600 M 10000 PPM ORAL/DENTAL 11-08-13 13:01 3 WET CLEAR MATERIAL AROUND MOUTH 11-08-13 13:01 3 SALIVATION 11-09-13 11:51 2 SALIVATION 11-10-13 13:11 1 WET CLEAR MATERIAL AROUND MOUTH 11-11-13 12:43 3 WET CLEAR MATERIAL AROUND MOUTH 11-11-13 12:43 1 SALIVATION 91603 M 10000 PPM NORMAL 10-15-13 12:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 11:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 11:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 12:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 12:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 13:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 14:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 11:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 11:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 12:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 11:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 11:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 11:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 11:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 13:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 12:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91603 M 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY 91603 M 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION 91603 M 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT 10-14-13 13:26 P LACRIMATION 91603 M 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION 10-18-13 11:46 1 SALIVATION

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TABLE RANGE: 10-14-13 TO 11-11-13

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----------------------------------------------------------------------------------------------------------------------------------- 91603 M 10000 PPM ORAL/DENTAL 10-18-13 11:46 1 WET CLEAR MATERIAL AROUND MOUTH 10-19-13 11:22 1 WET CLEAR MATERIAL AROUND MOUTH 10-23-13 11:42 1 WET CLEAR MATERIAL AROUND MOUTH 10-28-13 12:54 3 WET CLEAR MATERIAL AROUND MOUTH 10-28-13 12:54 3 SALIVATION 10-29-13 12:27 2 WET CLEAR MATERIAL AROUND MOUTH 10-31-13 11:51 2 WET CLEAR MATERIAL AROUND MOUTH 10-31-13 11:51 1 SALIVATION 11-04-13 12:05 2 WET CLEAR MATERIAL AROUND MOUTH 11-06-13 11:43 3 WET CLEAR MATERIAL AROUND MOUTH 11-06-13 11:43 1 SALIVATION 11-07-13 11:58 2 WET CLEAR MATERIAL AROUND MOUTH 11-09-13 11:53 2 WET CLEAR MATERIAL AROUND MOUTH 11-10-13 13:12 1 SALIVATION 91604 M 10000 PPM NORMAL 10-18-13 11:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 13:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 11:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91604 M 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY 91604 M 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION 91604 M 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT 10-14-13 13:26 P LACRIMATION 91604 M 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION 10-15-13 12:21 1 WET CLEAR MATERIAL AROUND MOUTH 10-16-13 12:16 1 WET CLEAR MATERIAL AROUND MOUTH 10-16-13 12:16 2 SALIVATION 10-17-13 11:58 1 WET CLEAR MATERIAL AROUND MOUTH 10-19-13 11:23 1 SALIVATION 10-20-13 11:21 1 SALIVATION 10-21-13 12:38 1 SALIVATION

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TABLE RANGE: 10-14-13 TO 11-11-13

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----------------------------------------------------------------------------------------------------------------------------------- 91604 M 10000 PPM ORAL/DENTAL 10-22-13 12:04 1 SALIVATION 10-23-13 11:48 1 SALIVATION 10-23-13 11:48 1 WET CLEAR MATERIAL AROUND MOUTH 10-25-13 14:12 1 SALIVATION 10-27-13 11:48 1 WET CLEAR MATERIAL AROUND MOUTH 10-28-13 12:55 2 WET CLEAR MATERIAL AROUND MOUTH 10-29-13 12:28 2 WET CLEAR MATERIAL AROUND MOUTH 10-29-13 12:28 2 SALIVATION 10-30-13 12:27 1 SALIVATION 10-31-13 11:51 3 WET CLEAR MATERIAL AROUND MOUTH 10-31-13 11:51 3 SALIVATION 11-01-13 11:38 3 WET CLEAR MATERIAL AROUND MOUTH 11-01-13 11:38 3 SALIVATION 11-02-13 11:35 3 WET CLEAR MATERIAL AROUND MOUTH 11-02-13 11:35 3 SALIVATION 11-03-13 11:16 2 WET CLEAR MATERIAL AROUND MOUTH 11-03-13 11:16 2 SALIVATION 11-04-13 12:06 2 WET CLEAR MATERIAL AROUND MOUTH 11-04-13 12:06 2 SALIVATION 11-05-13 11:23 3 WET CLEAR MATERIAL AROUND MOUTH 11-05-13 11:23 3 SALIVATION 11-06-13 11:44 3 WET CLEAR MATERIAL AROUND MOUTH 11-06-13 11:44 3 SALIVATION 11-07-13 11:58 3 WET CLEAR MATERIAL AROUND MOUTH 11-07-13 11:58 3 SALIVATION 11-08-13 13:02 2 WET CLEAR MATERIAL AROUND MOUTH 11-08-13 13:02 2 SALIVATION 11-09-13 11:55 2 SALIVATION 11-10-13 13:12 2 SALIVATION

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91605 M 10000 PPM NORMAL 10-15-13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 12:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 12:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 13:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 14:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 11:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91605 M 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY 91605 M 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION 91605 M 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT 10-14-13 13:26 P LACRIMATION 10-17-13 11:55 1 WET RED MATERIAL AROUND NOSE 10-18-13 11:46 1 WET RED MATERIAL AROUND NOSE 10-28-13 12:56 2 WET RED MATERIAL AROUND NOSE 11-01-13 11:38 2 WET RED MATERIAL AROUND NOSE 91605 M 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION 10-17-13 11:55 1 WET RED MATERIAL AROUND MOUTH 10-18-13 11:46 1 SALIVATION 10-18-13 11:46 1 WET CLEAR MATERIAL AROUND MOUTH 10-19-13 11:24 1 WET CLEAR MATERIAL AROUND MOUTH 10-19-13 11:24 1 SALIVATION 10-20-13 11:19 1 SALIVATION 10-21-13 12:36 1 WET CLEAR MATERIAL AROUND MOUTH 10-23-13 11:46 1 SALIVATION 10-27-13 11:47 1 SALIVATION 10-28-13 12:56 2 WET RED MATERIAL AROUND MOUTH 10-28-13 12:56 3 SALIVATION 10-29-13 12:29 3 WET CLEAR MATERIAL AROUND MOUTH 10-29-13 12:29 3 SALIVATION 10-30-13 12:28 1 SALIVATION

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91605 M 10000 PPM ORAL/DENTAL 10-31-13 11:52 3 WET CLEAR MATERIAL AROUND MOUTH 10-31-13 11:52 3 SALIVATION 11-02-13 11:36 2 WET CLEAR MATERIAL AROUND MOUTH 11-02-13 11:36 2 SALIVATION 11-03-13 11:17 3 WET CLEAR MATERIAL AROUND MOUTH 11-03-13 11:17 3 SALIVATION 11-04-13 12:07 1 WET CLEAR MATERIAL AROUND MOUTH 11-04-13 12:07 1 SALIVATION 11-05-13 11:24 3 WET CLEAR MATERIAL AROUND MOUTH 11-05-13 11:24 3 SALIVATION 11-06-13 11:45 3 WET CLEAR MATERIAL AROUND MOUTH 11-06-13 11:45 2 SALIVATION 11-07-13 11:59 3 WET CLEAR MATERIAL AROUND MOUTH 11-07-13 11:59 3 SALIVATION 11-08-13 13:03 3 WET CLEAR MATERIAL AROUND MOUTH 11-08-13 13:03 3 SALIVATION 11-09-13 11:54 1 WET CLEAR MATERIAL AROUND MOUTH 11-10-13 13:13 2 SALIVATION 11-11-13 12:43 3 WET CLEAR MATERIAL AROUND MOUTH 11-11-13 12:43 1 SALIVATION 91612 M 10000 PPM NORMAL 10-24-13 13:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 11:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91612 M 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY 91612 M 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION 91612 M 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT 10-14-13 13:26 P LACRIMATION 91612 M 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION 10-15-13 12:18 1 SALIVATION 10-16-13 12:19 2 SALIVATION

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91612 M 10000 PPM ORAL/DENTAL 10-16-13 12:19 2 WET CLEAR MATERIAL AROUND MOUTH 10-17-13 11:54 2 SALIVATION 10-18-13 11:47 2 SALIVATION 10-18-13 11:47 1 WET CLEAR MATERIAL AROUND MOUTH 10-19-13 11:25 2 SALIVATION 10-19-13 11:25 2 WET CLEAR MATERIAL AROUND MOUTH 10-20-13 11:19 2 SALIVATION 10-21-13 12:34 1 SALIVATION 10-22-13 12:02 2 SALIVATION 10-23-13 11:45 2 SALIVATION 10-23-13 11:45 2 WET CLEAR MATERIAL AROUND MOUTH 10-25-13 14:11 1 SALIVATION 10-26-13 11:54 1 SALIVATION 10-27-13 11:47 1 SALIVATION 10-28-13 12:57 3 WET CLEAR MATERIAL AROUND MOUTH 10-28-13 12:57 3 SALIVATION 10-29-13 12:29 3 WET CLEAR MATERIAL AROUND MOUTH 10-29-13 12:29 3 SALIVATION 10-30-13 12:28 2 SALIVATION 10-31-13 11:52 3 WET CLEAR MATERIAL AROUND MOUTH 10-31-13 11:52 3 SALIVATION 11-01-13 11:39 3 WET CLEAR MATERIAL AROUND MOUTH 11-01-13 11:39 3 SALIVATION 11-02-13 11:36 2 WET CLEAR MATERIAL AROUND MOUTH 11-02-13 11:37 2 SALIVATION 11-03-13 11:17 3 WET CLEAR MATERIAL AROUND MOUTH 11-03-13 11:17 3 SALIVATION 11-04-13 12:07 3 WET CLEAR MATERIAL AROUND MOUTH 11-04-13 12:07 3 SALIVATION

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91612 M 10000 PPM ORAL/DENTAL 11-06-13 11:45 3 WET CLEAR MATERIAL AROUND MOUTH 11-06-13 11:45 2 SALIVATION 11-07-13 11:59 3 WET CLEAR MATERIAL AROUND MOUTH 11-07-13 11:59 3 SALIVATION 11-08-13 13:03 3 WET CLEAR MATERIAL AROUND MOUTH 11-08-13 13:03 3 SALIVATION 11-09-13 11:53 2 SALIVATION 11-10-13 13:13 2 SALIVATION 11-11-13 12:44 3 WET CLEAR MATERIAL AROUND MOUTH 11-11-13 12:44 3 SALIVATION 91618 M 10000 PPM NORMAL 10-16-13 12:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 11:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 13:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 11:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 11:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91618 M 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY 91618 M 10000 PPM BODY/INTEGUMENT 10-21-13 12:35 1 WET CLEAR MATERIAL RIGHT FORELIMB 10-21-13 12:35 1 WET CLEAR MATERIAL LEFT FORELIMB 91618 M 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION 91618 M 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT 10-14-13 13:26 P LACRIMATION 10-28-13 12:56 3 WET RED MATERIAL AROUND NOSE 91618 M 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION 10-15-13 12:18 1 SALIVATION 10-17-13 11:54 1 WET CLEAR MATERIAL AROUND MOUTH 10-18-13 11:46 2 SALIVATION 10-18-13 11:46 1 WET CLEAR MATERIAL AROUND MOUTH 10-19-13 11:25 1 SALIVATION

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91618 M 10000 PPM ORAL/DENTAL 10-20-13 11:19 1 SALIVATION 10-20-13 11:19 1 WET CLEAR MATERIAL AROUND MOUTH 10-21-13 12:34 1 SALIVATION 10-25-13 14:11 1 WET CLEAR MATERIAL AROUND MOUTH 10-28-13 12:56 2 SALIVATION 10-29-13 12:29 2 WET CLEAR MATERIAL AROUND MOUTH 10-29-13 12:29 2 SALIVATION 10-30-13 12:28 1 WET CLEAR MATERIAL AROUND MOUTH 10-31-13 11:52 3 WET CLEAR MATERIAL AROUND MOUTH 10-31-13 11:52 3 SALIVATION 11-01-13 11:39 3 WET CLEAR MATERIAL AROUND MOUTH 11-01-13 11:39 3 SALIVATION 11-02-13 11:36 3 WET CLEAR MATERIAL AROUND MOUTH 11-02-13 11:36 2 SALIVATION 11-03-13 11:17 3 WET CLEAR MATERIAL AROUND MOUTH 11-03-13 11:17 2 SALIVATION 11-04-13 12:07 3 WET CLEAR MATERIAL AROUND MOUTH 11-04-13 12:07 3 SALIVATION 11-05-13 11:24 3 WET CLEAR MATERIAL AROUND MOUTH 11-05-13 11:24 3 SALIVATION 11-06-13 11:45 3 WET CLEAR MATERIAL AROUND MOUTH 11-06-13 11:45 2 SALIVATION 11-07-13 11:59 3 WET CLEAR MATERIAL AROUND MOUTH 11-07-13 11:59 3 SALIVATION 11-08-13 13:03 2 WET CLEAR MATERIAL AROUND MOUTH 11-09-13 11:54 2 WET CLEAR MATERIAL AROUND MOUTH 11-10-13 13:13 2 SALIVATION 11-11-13 12:44 3 WET CLEAR MATERIAL AROUND MOUTH 91619 M 10000 PPM NORMAL 10-15-13 12:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91619 M 10000 PPM NORMAL 10-17-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91619 M 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY 91619 M 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION 91619 M 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT 10-14-13 13:26 P LACRIMATION 10-18-13 11:44 2 DRIED RED MATERIAL AROUND NOSE 10-19-13 11:24 1 WET RED MATERIAL AROUND NOSE 10-20-13 11:20 1 WET RED MATERIAL AROUND NOSE 10-21-13 12:37 1 WET RED MATERIAL AROUND NOSE 10-23-13 11:47 2 WET RED MATERIAL AROUND NOSE 91619 M 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION 10-16-13 12:17 1 WET RED MATERIAL AROUND MOUTH 10-18-13 11:44 2 WET RED MATERIAL AROUND MOUTH 10-19-13 11:23 1 SALIVATION 10-19-13 11:23 1 WET RED MATERIAL AROUND MOUTH 10-20-13 11:20 1 WET RED MATERIAL AROUND MOUTH 10-20-13 11:20 1 SALIVATION 10-21-13 12:37 1 WET RED MATERIAL AROUND MOUTH 10-21-13 12:37 1 SALIVATION 10-22-13 12:03 1 SALIVATION 10-23-13 11:47 1 SALIVATION 10-23-13 11:48 1 WET RED MATERIAL AROUND MOUTH 10-24-13 13:40 1 SALIVATION 10-25-13 14:12 1 SALIVATION 10-26-13 11:53 1 SALIVATION 10-27-13 11:48 1 SALIVATION 10-28-13 12:55 3 WET CLEAR MATERIAL AROUND MOUTH 10-28-13 12:55 2 SALIVATION 10-29-13 12:28 3 WET CLEAR MATERIAL AROUND MOUTH

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91619 M 10000 PPM ORAL/DENTAL 10-29-13 12:28 3 SALIVATION 10-30-13 12:27 1 WET CLEAR MATERIAL AROUND MOUTH 10-31-13 11:51 3 WET CLEAR MATERIAL AROUND MOUTH 10-31-13 11:51 3 SALIVATION 11-01-13 11:38 3 WET CLEAR MATERIAL AROUND MOUTH 11-01-13 11:38 3 SALIVATION 11-02-13 11:35 3 WET CLEAR MATERIAL AROUND MOUTH 11-02-13 11:35 3 SALIVATION 11-03-13 11:16 3 WET CLEAR MATERIAL AROUND MOUTH 11-03-13 11:16 3 SALIVATION 11-04-13 12:06 3 WET CLEAR MATERIAL AROUND MOUTH 11-04-13 12:06 3 SALIVATION 11-05-13 11:23 3 WET CLEAR MATERIAL AROUND MOUTH 11-05-13 11:23 3 SALIVATION 11-06-13 11:44 3 WET CLEAR MATERIAL AROUND MOUTH 11-06-13 11:44 3 SALIVATION 11-07-13 11:59 3 WET CLEAR MATERIAL AROUND MOUTH 11-07-13 11:59 3 SALIVATION 11-08-13 13:03 3 WET CLEAR MATERIAL AROUND MOUTH 11-08-13 13:03 3 SALIVATION 11-09-13 11:55 1 SALIVATION 11-10-13 13:12 1 SALIVATION

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PCRDv4.18 11/25/2013 R:01/20/2014**Page 333 of 1107**TABLE A3 (F0 MALES - 1 HOUR POST-EXPOSURE - GROUP 5)

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91554 M 10000 PPM NORMAL 10-15-13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 13:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 12:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 11:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 11:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 13:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 13:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 12:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 12:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 13:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 13:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 13:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 12:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 12:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 12:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 13:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 12:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 13:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91554 M 10000 PPM ORAL/DENTAL 10-14-13 14:11 2 SALIVATION 10-14-13 14:12 2 WET CLEAR MATERIAL AROUND MOUTH 10-23-13 12:16 1 WET CLEAR MATERIAL AROUND MOUTH 11-04-13 12:38 2 WET CLEAR MATERIAL AROUND MOUTH

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91557 M 10000 PPM NORMAL 10-15-13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 13:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 12:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 12:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 11:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 11:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 13:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 12:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 12:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 13:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 13:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 13:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 12:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 12:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 12:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 12:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 12:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 13:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 12:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 13:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91557 M 10000 PPM EYES/EARS/NOSE 10-25-13 14:51 2 DRIED RED MATERIAL AROUND LEFT EYE 10-26-13 12:31 1 DRIED RED MATERIAL AROUND LEFT EYE 91557 M 10000 PPM ORAL/DENTAL 10-14-13 14:11 1 WET CLEAR MATERIAL AROUND MOUTH 91558 M 10000 PPM NORMAL 10-15-13 13:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91558 M 10000 PPM NORMAL 10-16-13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 12:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 12:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 12:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 13:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 12:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 12:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 13:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91558 M 10000 PPM EYES/EARS/NOSE 10-25-13 14:51 2 DRIED RED MATERIAL AROUND NOSE 10-28-13 13:38 2 WET RED MATERIAL AROUND NOSE 10-29-13 13:06 2 WET RED MATERIAL AROUND NOSE 11-06-13 12:20 2 DRIED RED MATERIAL AROUND NOSE 11-07-13 12:35 2 DRIED RED MATERIAL AROUND NOSE 11-09-13 12:34 1 DRIED RED MATERIAL AROUND NOSE 91558 M 10000 PPM ORAL/DENTAL 10-14-13 14:14 2 WET CLEAR MATERIAL AROUND MOUTH 10-19-13 11:56 1 WET RED MATERIAL AROUND MOUTH 10-20-13 11:54 1 WET RED MATERIAL AROUND MOUTH 10-21-13 13:10 1 DRIED RED MATERIAL AROUND MOUTH 10-23-13 12:18 1 WET RED MATERIAL AROUND MOUTH 10-24-13 14:14 1 WET RED MATERIAL AROUND MOUTH 10-28-13 13:38 3 WET CLEAR MATERIAL AROUND MOUTH 10-29-13 13:06 2 WET RED MATERIAL AROUND MOUTH 10-31-13 12:33 1 WET CLEAR MATERIAL AROUND MOUTH 11-02-13 12:14 2 WET CLEAR MATERIAL AROUND MOUTH 11-04-13 12:40 1 WET CLEAR MATERIAL AROUND MOUTH 11-05-13 11:58 1 WET CLEAR MATERIAL AROUND MOUTH 11-06-13 12:20 1 DRIED RED MATERIAL AROUND MOUTH

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91558 M 10000 PPM ORAL/DENTAL 11-09-13 12:34 1 WET RED MATERIAL AROUND MOUTH 11-10-13 13:51 1 WET RED MATERIAL AROUND MOUTH 91571 M 10000 PPM NORMAL 10-15-13 13:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 13:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 12:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 12:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 11:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 11:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 13:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 13:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 12:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 12:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 12:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 13:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 13:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 12:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 12:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 12:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 12:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 13:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 12:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 13:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 13:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91571 M 10000 PPM EYES/EARS/NOSE 10-25-13 14:52 3 DRIED RED MATERIAL AROUND NOSE

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91571 M 10000 PPM EYES/EARS/NOSE 10-29-13 13:02 2 DRIED RED MATERIAL AROUND NOSE 91571 M 10000 PPM ORAL/DENTAL 10-14-13 14:12 1 WET CLEAR MATERIAL AROUND MOUTH 91575 M 10000 PPM NORMAL 10-15-13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 13:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 12:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 12:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 11:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 11:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 13:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 12:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 12:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 13:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 13:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 13:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 12:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 12:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 12:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 13:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 12:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91575 M 10000 PPM EYES/EARS/NOSE 10-14-13 14:09 1 DRIED RED MATERIAL AROUND NOSE 11-10-13 13:49 1 WET RED MATERIAL AROUND NOSE 91575 M 10000 PPM ORAL/DENTAL 11-03-13 12:00 2 WET RED MATERIAL AROUND MOUTH 11-04-13 12:39 1 WET CLEAR MATERIAL AROUND MOUTH

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91575 M 10000 PPM ORAL/DENTAL 11-06-13 12:19 2 WET CLEAR MATERIAL AROUND MOUTH 11-10-13 13:49 1 WET RED MATERIAL AROUND MOUTH 91600 M 10000 PPM NORMAL 10-14-13 14:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 13:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 12:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 11:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 13:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 12:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 12:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 13:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 13:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 13:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 12:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91600 M 10000 PPM EYES/EARS/NOSE 10-23-13 12:16 1 WET RED MATERIAL AROUND NOSE 11-09-13 12:32 1 WET RED MATERIAL AROUND NOSE 11-10-13 13:50 1 WET RED MATERIAL AROUND NOSE 91600 M 10000 PPM ORAL/DENTAL 10-19-13 11:54 1 WET CLEAR MATERIAL AROUND MOUTH 10-21-13 13:07 1 DRIED RED MATERIAL AROUND MOUTH 10-23-13 12:16 1 WET RED MATERIAL AROUND MOUTH 11-02-13 12:12 1 WET RED MATERIAL AROUND MOUTH 11-03-13 11:59 1 WET CLEAR MATERIAL AROUND MOUTH 11-04-13 12:38 1 WET CLEAR MATERIAL AROUND MOUTH 11-05-13 11:57 1 WET CLEAR MATERIAL AROUND MOUTH 11-06-13 12:19 2 WET CLEAR MATERIAL AROUND MOUTH

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91600 M 10000 PPM ORAL/DENTAL 11-07-13 12:33 2 WET CLEAR MATERIAL AROUND MOUTH 11-08-13 13:38 2 WET CLEAR MATERIAL AROUND MOUTH 11-09-13 12:32 1 WET RED MATERIAL AROUND MOUTH 11-10-13 13:50 1 WET RED MATERIAL AROUND MOUTH 11-11-13 13:18 2 WET CLEAR MATERIAL AROUND MOUTH 91603 M 10000 PPM NORMAL 10-14-13 14:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 13:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 12:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 12:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 11:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 11:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 13:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 12:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 12:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 12:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 13:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 13:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 13:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 12:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 12:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 12:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 12:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91603 M 10000 PPM NORMAL 11-07-13 12:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 13:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 12:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 13:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 13:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91604 M 10000 PPM NORMAL 10-14-13 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 13:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 12:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 12:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 11:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 11:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 13:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 12:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 12:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 13:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 12:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 12:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91604 M 10000 PPM EYES/EARS/NOSE 10-28-13 13:37 3 DRIED RED MATERIAL AROUND NOSE 10-29-13 13:04 2 WET RED MATERIAL AROUND NOSE 11-05-13 11:58 1 WET RED MATERIAL AROUND NOSE 11-06-13 12:20 2 DRIED RED MATERIAL AROUND NOSE 11-10-13 13:51 1 DRIED RED MATERIAL AROUND NOSE 91604 M 10000 PPM ORAL/DENTAL 10-23-13 12:19 1 WET RED MATERIAL AROUND MOUTH

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91604 M 10000 PPM ORAL/DENTAL 10-28-13 13:37 1 DRIED RED MATERIAL AROUND MOUTH 10-29-13 13:04 2 WET RED MATERIAL AROUND MOUTH 11-03-13 12:00 1 WET CLEAR MATERIAL AROUND MOUTH 11-04-13 12:40 1 WET CLEAR MATERIAL AROUND MOUTH 11-05-13 11:58 2 WET CLEAR MATERIAL AROUND MOUTH 11-07-13 12:34 2 WET CLEAR MATERIAL AROUND MOUTH 11-08-13 13:39 2 WET CLEAR MATERIAL AROUND MOUTH 11-10-13 13:51 1 DRIED RED MATERIAL AROUND MOUTH 91605 M 10000 PPM NORMAL 10-15-13 13:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 12:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 11:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 13:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 12:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 12:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 13:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 13:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 12:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 12:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 12:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 12:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91605 M 10000 PPM NORMAL 11-05-13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 12:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 13:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 12:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 13:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 13:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91605 M 10000 PPM ORAL/DENTAL 10-14-13 14:14 1 WET CLEAR MATERIAL AROUND MOUTH 91612 M 10000 PPM NORMAL 10-15-13 13:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 12:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 12:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 13:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 13:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 12:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 13:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 12:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 12:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 12:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 12:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91612 M 10000 PPM EYES/EARS/NOSE 11-10-13 13:50 1 WET RED MATERIAL AROUND NOSE 91612 M 10000 PPM ORAL/DENTAL 10-14-13 14:13 2 WET CLEAR MATERIAL AROUND MOUTH 10-14-13 14:13 1 SALIVATION 10-19-13 11:57 1 WET RED MATERIAL AROUND MOUTH

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91612 M 10000 PPM ORAL/DENTAL 10-20-13 11:53 1 WET RED MATERIAL AROUND MOUTH 10-23-13 12:17 1 WET RED MATERIAL AROUND MOUTH 10-24-13 14:13 2 WET CLEAR MATERIAL AROUND MOUTH 10-28-13 13:38 1 WET RED MATERIAL AROUND MOUTH 10-29-13 13:06 3 WET CLEAR MATERIAL AROUND MOUTH 10-31-13 12:34 1 WET CLEAR MATERIAL AROUND MOUTH 11-04-13 12:40 1 WET CLEAR MATERIAL AROUND MOUTH 11-08-13 13:40 2 WET CLEAR MATERIAL AROUND MOUTH 11-10-13 13:50 1 WET RED MATERIAL AROUND MOUTH 11-11-13 13:19 2 WET CLEAR MATERIAL AROUND MOUTH 91618 M 10000 PPM NORMAL 10-15-13 13:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 12:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 11:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 13:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 12:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 12:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 13:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 13:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 12:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 12:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91618 M 10000 PPM NORMAL 11-04-13 12:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 12:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 13:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 12:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 13:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 13:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91618 M 10000 PPM ORAL/DENTAL 10-14-13 14:13 2 WET CLEAR MATERIAL AROUND MOUTH 11-01-13 12:13 2 WET CLEAR MATERIAL AROUND MOUTH 91619 M 10000 PPM NORMAL 10-14-13 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 13:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 12:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 12:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 11:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 11:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 13:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 12:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 13:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 12:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91619 M 10000 PPM EYES/EARS/NOSE 10-23-13 12:19 1 DRIED RED MATERIAL AROUND NOSE 10-25-13 14:53 3 DRIED RED MATERIAL AROUND NOSE 10-29-13 13:05 2 DRIED RED MATERIAL AROUND NOSE

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91619 M 10000 PPM EYES/EARS/NOSE 11-07-13 12:35 2 DRIED RED MATERIAL AROUND NOSE 11-10-13 13:51 1 WET RED MATERIAL AROUND NOSE 91619 M 10000 PPM ORAL/DENTAL 10-23-13 12:19 1 DRIED RED MATERIAL AROUND MOUTH 10-28-13 13:37 1 DRIED RED MATERIAL AROUND MOUTH 10-29-13 13:05 1 DRIED RED MATERIAL AROUND MOUTH 11-01-13 12:13 1 WET RED MATERIAL AROUND MOUTH 11-04-13 12:40 1 WET CLEAR MATERIAL AROUND MOUTH 11-05-13 11:58 1 WET CLEAR MATERIAL AROUND MOUTH 11-06-13 12:20 1 WET CLEAR MATERIAL AROUND MOUTH 11-07-13 12:35 2 WET RED MATERIAL AROUND MOUTH 11-08-13 13:39 2 WET CLEAR MATERIAL AROUND MOUTH 11-09-13 12:34 1 WET RED MATERIAL AROUND MOUTH 11-10-13 13:51 1 WET RED MATERIAL AROUND MOUTH

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91555 M 0 PPM NORMAL 10-14-13 17:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91560 M 0 PPM NORMAL 10-14-13 17:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91562 M 0 PPM NORMAL 10-14-13 17:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91563 M 0 PPM NORMAL 10-17-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91563 M 0 PPM NORMAL 10-18-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91563 M 0 PPM EYES/EARS/NOSE 10-14-13 17:09 1 DRIED RED MATERIAL AROUND NOSE 10-15-13 15:40 2 DRIED RED MATERIAL AROUND NOSE 10-16-13 15:21 1 DRIED RED MATERIAL AROUND NOSE 10-21-13 15:58 1 DRIED RED MATERIAL AROUND NOSE 10-23-13 15:06 2 DRIED RED MATERIAL AROUND NOSE 10-24-13 14:56 1 DRIED RED MATERIAL AROUND NOSE 10-25-13 15:19 1 DRIED RED MATERIAL AROUND NOSE 10-29-13 15:40 1 DRIED RED MATERIAL AROUND NOSE 91564 M 0 PPM NORMAL 10-14-13 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91564 M 0 PPM NORMAL 10-16-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91567 M 0 PPM NORMAL 10-14-13 17:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91567 M 0 PPM NORMAL 10-16-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91579 M 0 PPM NORMAL 10-14-13 17:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91579 M 0 PPM NORMAL 10-17-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91586 M 0 PPM NORMAL 10-16-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91586 M 0 PPM NORMAL 10-19-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91586 M 0 PPM EYES/EARS/NOSE 10-14-13 17:10 3 DRIED RED MATERIAL AROUND NOSE 10-15-13 15:41 1 DRIED RED MATERIAL AROUND NOSE 10-20-13 14:44 1 DRIED RED MATERIAL AROUND NOSE 10-22-13 15:19 1 DRIED RED MATERIAL AROUND NOSE 11-08-13 14:57 1 DRIED RED MATERIAL AROUND NOSE 91591 M 0 PPM NORMAL 10-14-13 17:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91591 M 0 PPM NORMAL 10-18-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91592 M 0 PPM NORMAL 10-14-13 17:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91592 M 0 PPM NORMAL 10-20-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91592 M 0 PPM EYES/EARS/NOSE 10-15-13 15:41 1 DRIED RED MATERIAL AROUND NOSE 91609 M 0 PPM NORMAL 10-14-13 17:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91609 M 0 PPM NORMAL 10-19-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91615 M 0 PPM NORMAL 10-14-13 17:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91615 M 0 PPM NORMAL 10-20-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91615 M 0 PPM EYES/EARS/NOSE 10-18-13 15:11 1 DRIED RED MATERIAL AROUND NOSE 91556 M 50 PPM NORMAL 10-14-13 17:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91556 M 50 PPM NORMAL 10-20-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91559 M 50 PPM NORMAL 10-14-13 17:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91559 M 50 PPM NORMAL 10-20-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91559 M 50 PPM EYES/EARS/NOSE 10-21-13 15:59 1 DRIED RED MATERIAL AROUND NOSE 10-25-13 15:21 1 DRIED RED MATERIAL AROUND NOSE 91561 M 50 PPM NORMAL 10-14-13 17:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91561 M 50 PPM NORMAL 10-21-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91561 M 50 PPM EYES/EARS/NOSE 10-18-13 15:11 1 DRIED RED MATERIAL AROUND NOSE 91561 M 50 PPM ORAL/DENTAL 10-18-13 15:12 1 WET RED MATERIAL AROUND MOUTH 91566 M 50 PPM NORMAL 10-15-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91566 M 50 PPM NORMAL 10-21-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91566 M 50 PPM EYES/EARS/NOSE 10-14-13 17:13 1 DRIED RED MATERIAL AROUND NOSE 10-23-13 15:11 1 DRIED RED MATERIAL AROUND NOSE 11-02-13 14:55 1 DRIED RED MATERIAL AROUND NOSE 11-09-13 15:09 1 DRIED RED MATERIAL AROUND NOSE 91576 M 50 PPM NORMAL 10-14-13 17:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91576 M 50 PPM NORMAL 10-21-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91576 M 50 PPM EYES/EARS/NOSE 10-22-13 15:21 1 DRIED RED MATERIAL AROUND NOSE 11-01-13 15:03 1 DRIED RED MATERIAL AROUND NOSE 91582 M 50 PPM NORMAL 10-14-13 17:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91582 M 50 PPM NORMAL 10-23-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91582 M 50 PPM EYES/EARS/NOSE 10-21-13 16:00 1 DRIED RED MATERIAL AROUND NOSE 10-25-13 15:21 1 DRIED RED MATERIAL AROUND NOSE 10-29-13 15:43 1 DRIED RED MATERIAL AROUND NOSE 11-02-13 14:55 1 DRIED RED MATERIAL AROUND NOSE 91585 M 50 PPM NORMAL 10-15-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91585 M 50 PPM NORMAL 10-25-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91585 M 50 PPM EYES/EARS/NOSE 10-14-13 17:14 1 DRIED RED MATERIAL AROUND NOSE 10-18-13 15:13 2 DRIED RED MATERIAL AROUND NOSE 10-22-13 15:21 1 DRIED RED MATERIAL AROUND NOSE 91589 M 50 PPM NORMAL 10-14-13 17:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91589 M 50 PPM NORMAL 10-22-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91589 M 50 PPM EYES/EARS/NOSE 10-29-13 15:44 1 DRIED RED MATERIAL AROUND NOSE 91593 M 50 PPM NORMAL 10-14-13 17:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91593 M 50 PPM NORMAL 10-25-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91593 M 50 PPM EYES/EARS/NOSE 10-22-13 15:22 1 DRIED RED MATERIAL AROUND NOSE 10-24-13 14:59 1 DRIED RED MATERIAL AROUND NOSE 11-05-13 14:38 1 DRIED RED MATERIAL AROUND NOSE 91594 M 50 PPM NORMAL 10-14-13 17:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91594 M 50 PPM NORMAL 10-29-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91594 M 50 PPM EYES/EARS/NOSE 10-18-13 15:14 2 DRIED RED MATERIAL AROUND NOSE 10-20-13 14:47 1 DRIED RED MATERIAL AROUND NOSE 10-21-13 16:01 1 DRIED RED MATERIAL AROUND NOSE 10-24-13 14:59 1 DRIED RED MATERIAL AROUND NOSE 10-25-13 15:22 1 DRIED RED MATERIAL AROUND NOSE 91595 M 50 PPM NORMAL 10-14-13 17:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91595 M 50 PPM NORMAL 10-25-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91595 M 50 PPM EYES/EARS/NOSE 11-06-13 14:54 1 DRIED RED MATERIAL AROUND NOSE 11-08-13 14:59 1 DRIED RED MATERIAL AROUND NOSE 91602 M 50 PPM NORMAL 10-14-13 17:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91602 M 50 PPM NORMAL 10-26-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91602 M 50 PPM EYES/EARS/NOSE 10-21-13 16:01 2 DRIED RED MATERIAL AROUND NOSE 91569 M 100 PPM NORMAL 10-14-13 17:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91569 M 100 PPM NORMAL 10-25-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91573 M 100 PPM NORMAL 10-14-13 17:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91573 M 100 PPM NORMAL 10-30-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91573 M 100 PPM EYES/EARS/NOSE 10-18-13 15:15 1 DRIED RED MATERIAL AROUND NOSE 10-20-13 14:49 1 DRIED RED MATERIAL AROUND NOSE 10-22-13 15:23 2 DRIED RED MATERIAL AROUND NOSE 10-24-13 15:00 2 DRIED RED MATERIAL AROUND NOSE 10-25-13 15:24 1 DRIED RED MATERIAL AROUND LEFT EYE 10-25-13 15:24 1 DRIED RED MATERIAL AROUND RIGHT EYE 10-25-13 15:24 2 WET RED MATERIAL AROUND NOSE 11-09-13 15:12 1 DRIED RED MATERIAL AROUND LEFT EYE 11-09-13 15:12 1 DRIED RED MATERIAL AROUND RIGHT EYE 11-10-13 17:03 1 DRIED RED MATERIAL AROUND LEFT EYE 11-10-13 17:03 1 DRIED RED MATERIAL AROUND RIGHT EYE 91577 M 100 PPM NORMAL 10-14-13 17:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91577 M 100 PPM NORMAL 10-22-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91581 M 100 PPM NORMAL 10-14-13 17:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91581 M 100 PPM NORMAL 10-23-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91581 M 100 PPM EYES/EARS/NOSE 10-15-13 15:45 1 DRIED RED MATERIAL AROUND NOSE 91583 M 100 PPM NORMAL 10-14-13 17:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 29 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91583 M 100 PPM NORMAL 10-23-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91588 M 100 PPM NORMAL 10-14-13 17:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 30 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91588 M 100 PPM NORMAL 10-25-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91588 M 100 PPM EYES/EARS/NOSE 10-23-13 15:14 1 DRIED RED MATERIAL AROUND NOSE 91590 M 100 PPM NORMAL 10-14-13 17:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91590 M 100 PPM NORMAL 10-25-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91590 M 100 PPM EYES/EARS/NOSE 10-18-13 15:16 1 DRIED RED MATERIAL AROUND NOSE 91598 M 100 PPM NORMAL 10-14-13 17:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91598 M 100 PPM NORMAL 10-27-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91598 M 100 PPM EYES/EARS/NOSE 10-23-13 15:14 2 DRIED RED MATERIAL AROUND NOSE 10-24-13 15:01 1 DRIED RED MATERIAL AROUND NOSE 11-04-13 15:22 1 DRIED RED MATERIAL AROUND NOSE 91599 M 100 PPM NORMAL 10-14-13 17:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91599 M 100 PPM NORMAL 10-25-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91608 M 100 PPM NORMAL 10-14-13 17:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91608 M 100 PPM NORMAL 10-26-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91611 M 100 PPM NORMAL 10-14-13 17:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91611 M 100 PPM NORMAL 10-30-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91611 M 100 PPM EYES/EARS/NOSE 10-22-13 15:24 1 DRIED RED MATERIAL AROUND NOSE 10-23-13 15:14 1 DRIED RED MATERIAL AROUND NOSE 10-24-13 15:01 1 DRIED RED MATERIAL AROUND NOSE 10-29-13 15:47 1 DRIED RED MATERIAL AROUND NOSE 91616 M 100 PPM NORMAL 10-15-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91616 M 100 PPM NORMAL 10-28-13 16:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91616 M 100 PPM EYES/EARS/NOSE 10-14-13 17:19 1 DRIED RED MATERIAL AROUND NOSE 91565 M 175 PPM NORMAL 10-14-13 17:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91565 M 175 PPM NORMAL 10-28-13 16:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91565 M 175 PPM EYES/EARS/NOSE 10-24-13 15:02 1 DRIED RED MATERIAL AROUND NOSE 11-02-13 14:58 1 DRIED RED MATERIAL AROUND NOSE 91568 M 175 PPM NORMAL 10-14-13 17:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91568 M 175 PPM NORMAL 10-27-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91568 M 175 PPM EYES/EARS/NOSE 11-02-13 14:58 1 DRIED RED MATERIAL AROUND NOSE 91570 M 175 PPM NORMAL 10-14-13 17:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91570 M 175 PPM NORMAL 10-28-13 16:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91572 M 175 PPM NORMAL 10-14-13 17:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91572 M 175 PPM NORMAL 11-02-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91572 M 175 PPM EYES/EARS/NOSE 10-21-13 16:06 3 DRIED RED MATERIAL AROUND NOSE 10-22-13 15:25 2 DRIED RED MATERIAL AROUND NOSE 10-24-13 15:02 1 DRIED RED MATERIAL AROUND NOSE 11-01-13 15:07 1 DRIED RED MATERIAL AROUND NOSE 91580 M 175 PPM NORMAL 10-14-13 17:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91580 M 175 PPM NORMAL 11-02-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91580 M 175 PPM EYES/EARS/NOSE 10-20-13 14:51 1 DRIED RED MATERIAL AROUND NOSE 10-24-13 15:02 2 DRIED RED MATERIAL AROUND NOSE 10-25-13 15:26 1 DRIED RED MATERIAL AROUND NOSE 10-29-13 15:48 1 DRIED RED MATERIAL AROUND NOSE 91584 M 175 PPM NORMAL 10-15-13 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91584 M 175 PPM NORMAL 10-30-13 15:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91584 M 175 PPM EYES/EARS/NOSE 10-14-13 17:21 1 DRIED RED MATERIAL AROUND NOSE 91587 M 175 PPM NORMAL 10-15-13 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91587 M 175 PPM NORMAL 11-04-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91587 M 175 PPM EYES/EARS/NOSE 10-14-13 17:21 1 DRIED RED MATERIAL AROUND NOSE 10-24-13 15:03 1 DRIED RED MATERIAL AROUND NOSE 10-25-13 15:27 1 DRIED RED MATERIAL AROUND NOSE 91587 M 175 PPM ORAL/DENTAL 10-18-13 15:19 1 WET RED MATERIAL AROUND MOUTH 10-20-13 14:51 1 DRIED RED MATERIAL AROUND MOUTH 10-24-13 15:03 1 WET CLEAR MATERIAL AROUND MOUTH 91597 M 175 PPM NORMAL 10-14-13 17:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91597 M 175 PPM NORMAL 10-31-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91597 M 175 PPM EYES/EARS/NOSE 10-25-13 15:27 1 DRIED RED MATERIAL AROUND NOSE 91601 M 175 PPM NORMAL 10-14-13 17:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91601 M 175 PPM NORMAL 10-31-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91601 M 175 PPM EYES/EARS/NOSE 10-21-13 16:07 1 DRIED RED MATERIAL AROUND NOSE 91607 M 175 PPM NORMAL 10-14-13 17:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91607 M 175 PPM NORMAL 11-02-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91607 M 175 PPM EYES/EARS/NOSE 10-23-13 15:20 1 DRIED RED MATERIAL AROUND NOSE 10-24-13 15:04 1 DRIED RED MATERIAL AROUND NOSE 91613 M 175 PPM NORMAL 10-14-13 17:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91613 M 175 PPM NORMAL 11-03-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91613 M 175 PPM EYES/EARS/NOSE 10-18-13 15:19 1 DRIED RED MATERIAL AROUND NOSE 10-20-13 14:52 1 DRIED RED MATERIAL AROUND NOSE 91614 M 175 PPM NORMAL 10-14-13 17:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91614 M 175 PPM NORMAL 11-02-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91614 M 175 PPM ORAL/DENTAL 10-28-13 16:57 1 WET CLEAR MATERIAL AROUND MOUTH 91554 M 10000 PPM NORMAL 10-14-13 17:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91554 M 10000 PPM NORMAL 11-01-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91557 M 10000 PPM NORMAL 10-14-13 17:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91557 M 10000 PPM NORMAL 11-04-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91557 M 10000 PPM EYES/EARS/NOSE 10-25-13 15:28 1 DRIED RED MATERIAL AROUND LEFT EYE 10-25-13 15:28 1 DRIED RED MATERIAL AROUND RIGHT EYE 10-26-13 14:54 1 DRIED RED MATERIAL AROUND LEFT EYE 91558 M 10000 PPM NORMAL 10-14-13 17:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91558 M 10000 PPM NORMAL 11-04-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91558 M 10000 PPM EYES/EARS/NOSE 10-24-13 15:05 2 DRIED RED MATERIAL AROUND NOSE 10-29-13 15:51 1 DRIED RED MATERIAL AROUND NOSE 91571 M 10000 PPM NORMAL 10-14-13 17:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91571 M 10000 PPM NORMAL 11-06-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91571 M 10000 PPM EYES/EARS/NOSE 10-22-13 15:27 1 DRIED RED MATERIAL AROUND NOSE 10-23-13 15:21 1 DRIED RED MATERIAL AROUND NOSE 10-29-13 15:51 1 DRIED RED MATERIAL AROUND NOSE 91575 M 10000 PPM NORMAL 10-14-13 17:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91575 M 10000 PPM NORMAL 11-03-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91600 M 10000 PPM NORMAL 10-14-13 17:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91600 M 10000 PPM NORMAL 11-05-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91600 M 10000 PPM EYES/EARS/NOSE 10-18-13 15:22 1 DRIED RED MATERIAL AROUND NOSE 91603 M 10000 PPM NORMAL 10-14-13 17:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91603 M 10000 PPM NORMAL 11-04-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91604 M 10000 PPM NORMAL 10-14-13 17:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91604 M 10000 PPM NORMAL 11-04-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91605 M 10000 PPM NORMAL 10-14-13 17:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91605 M 10000 PPM NORMAL 11-05-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91612 M 10000 PPM NORMAL 10-14-13 17:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91612 M 10000 PPM NORMAL 11-05-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91618 M 10000 PPM NORMAL 10-14-13 17:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91618 M 10000 PPM NORMAL 11-06-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91618 M 10000 PPM EYES/EARS/NOSE 10-20-13 14:58 1 DRIED RED MATERIAL AROUND NOSE 91619 M 10000 PPM NORMAL 10-14-13 17:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-11-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91619 M 10000 PPM NORMAL 11-05-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PCRDv4.18 11/25/2013 R:01/20/2014**Page 406 of 1107**TABLE A5 (F0 FEMALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

TABLE RANGE: 10-14-13 TO 12-05-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91629 F 0 PPM NORMAL 10-14-13 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91629 F 0 PPM DISPOSITION 11-25-13 8:52 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91629 F 0 PPM BODY/INTEGUMENT 10-21-13 6:34 1 HAIR LOSS RIGHT FORELIMB 10-21-13 6:34 1 HAIR LOSS LEFT FORELIMB 10-27-13 6:19 1 HAIR LOSS RIGHT FORELIMB 10-27-13 6:19 1 HAIR LOSS LEFT FORELIMB 11-04-13 7:21 1 HAIR LOSS RIGHT FORELIMB 11-04-13 7:21 1 HAIR LOSS LEFT FORELIMB 11-10-13 7:22 1 HAIR LOSS RIGHT FORELIMB 11-10-13 7:22 1 HAIR LOSS LEFT FORELIMB 11-18-13 7:50 1 HAIR LOSS RIGHT FORELIMB 11-18-13 7:50 2 HAIR LOSS LEFT FORELIMB 11-25-13 7:37 2 HAIR LOSS RIGHT FORELIMB 11-25-13 7:37 2 HAIR LOSS LEFT FORELIMB 91630 F 0 PPM NORMAL 10-14-13 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-25-13 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-26-13 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91630 F 0 PPM DISPOSITION 11-26-13 8:40 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91633 F 0 PPM NORMAL 10-14-13 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91633 F 0 PPM DISPOSITION 11-23-13 10:44 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91637 F 0 PPM NORMAL 10-14-13 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 8:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91637 F 0 PPM DISPOSITION 11-22-13 8:51 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91637 F 0 PPM BODY/INTEGUMENT 11-10-13 7:25 1 HAIR LOSS RIGHT INGUINAL AREA 11-10-13 7:25 2 HAIR LOSS VENTRAL ABDOMINAL AREA 11-18-13 7:51 3 HAIR LOSS VENTRAL ABDOMINAL AREA 11-19-13 9:19 2 HAIR LOSS VENTRAL ABDOMINAL AREA 91639 F 0 PPM NORMAL 10-14-13 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-25-13 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91639 F 0 PPM DISPOSITION 11-25-13 8:52 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91644 F 0 PPM NORMAL 10-14-13 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91644 F 0 PPM DISPOSITION 11-23-13 10:45 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91645 F 0 PPM NORMAL 10-14-13 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-05-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91645 F 0 PPM NORMAL 11-04-13 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91645 F 0 PPM DISPOSITION 11-26-13 8:41 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91645 F 0 PPM BODY/INTEGUMENT 11-18-13 7:52 2 HAIR LOSS VENTRAL ABDOMINAL AREA 11-25-13 7:43 1 HAIR LOSS VENTRAL ABDOMINAL AREA 11-26-13 7:15 2 HAIR LOSS VENTRAL ABDOMINAL AREA 11-26-13 7:15 1 HAIR LOSS RIGHT FORELIMB 91648 F 0 PPM NORMAL 10-14-13 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 8:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91648 F 0 PPM DISPOSITION 11-23-13 10:45 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91653 F 0 PPM NORMAL 10-14-13 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-25-13 7:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91653 F 0 PPM DISPOSITION 11-25-13 8:52 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91660 F 0 PPM NORMAL 10-14-13 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-05-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91660 F 0 PPM NORMAL 11-25-13 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91660 F 0 PPM DISPOSITION 11-25-13 8:52 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91670 F 0 PPM NORMAL 10-14-13 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91670 F 0 PPM DISPOSITION 11-26-13 8:41 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91670 F 0 PPM BODY/INTEGUMENT 11-10-13 7:28 1 HAIR LOSS RIGHT FORELIMB 11-18-13 7:53 2 HAIR LOSS RIGHT FORELIMB 11-18-13 7:53 2 HAIR LOSS LEFT FORELIMB 11-25-13 7:46 1 HAIR LOSS LEFT FORELIMB 11-25-13 7:46 2 HAIR LOSS RIGHT FORELIMB 11-26-13 7:16 3 HAIR LOSS RIGHT FORELIMB 11-26-13 7:16 1 HAIR LOSS LEFT FORELIMB 91672 F 0 PPM NORMAL 10-14-13 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-25-13 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-26-13 7:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91672 F 0 PPM DISPOSITION 11-26-13 8:42 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91632 F 50 PPM NORMAL 10-14-13 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-05-13

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----------------------------------------------------------------------------------------------------------------------------------- 91632 F 50 PPM NORMAL 11-25-13 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-27-13 7:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91632 F 50 PPM DISPOSITION 11-27-13 8:26 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91640 F 50 PPM NORMAL 10-14-13 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-25-13 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-27-13 7:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91640 F 50 PPM DISPOSITION 11-27-13 8:26 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91642 F 50 PPM NORMAL 10-14-13 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-24-13 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91642 F 50 PPM DISPOSITION 11-24-13 9:00 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91642 F 50 PPM EYES/EARS/NOSE 11-10-13 7:29 1 DRIED RED MATERIAL AROUND NOSE 91647 F 50 PPM NORMAL 10-14-13 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-25-13 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-26-13 7:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91647 F 50 PPM DISPOSITION 11-26-13 8:43 P SCHEDULED EUTHANASIA; LACTATION DAY 4

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TABLE RANGE: 10-14-13 TO 12-05-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91651 F 50 PPM NORMAL 10-14-13 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-25-13 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91651 F 50 PPM DISPOSITION 11-25-13 8:52 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91659 F 50 PPM NORMAL 10-14-13 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-24-13 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91659 F 50 PPM DISPOSITION 11-24-13 9:00 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91661 F 50 PPM NORMAL 10-14-13 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 8:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91661 F 50 PPM DISPOSITION 11-23-13 10:45 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91663 F 50 PPM NORMAL 10-14-13 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-05-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91663 F 50 PPM NORMAL 11-18-13 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-25-13 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91663 F 50 PPM DISPOSITION 11-25-13 8:53 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91669 F 50 PPM NORMAL 10-14-13 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 8:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91669 F 50 PPM DISPOSITION 11-23-13 10:45 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91669 F 50 PPM BODY/INTEGUMENT 11-18-13 7:56 3 HAIR LOSS RIGHT FORELIMB 11-18-13 7:56 2 HAIR LOSS LEFT FORELIMB 91673 F 50 PPM NORMAL 10-21-13 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-25-13 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91673 F 50 PPM DISPOSITION 11-26-13 8:43 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91673 F 50 PPM BODY/INTEGUMENT 10-14-13 7:41 1 HAIR LOSS LEFT FORELIMB 11-10-13 7:31 1 HAIR LOSS RIGHT FORELIMB 11-26-13 7:18 1 HAIR LOSS RIGHT FORELIMB 11-26-13 7:18 2 HAIR LOSS LEFT FORELIMB 91683 F 50 PPM NORMAL 10-14-13 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-25-13 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-05-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91683 F 50 PPM NORMAL 11-27-13 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91683 F 50 PPM DISPOSITION 11-27-13 8:26 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91685 F 50 PPM NORMAL 10-14-13 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 8:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91685 F 50 PPM DISPOSITION 11-23-13 10:46 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91620 F 100 PPM NORMAL 10-14-13 7:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91620 F 100 PPM DISPOSITION 11-26-13 8:44 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91620 F 100 PPM BODY/INTEGUMENT 11-18-13 7:58 1 HAIR LOSS RIGHT FORELIMB 11-18-13 7:58 1 HAIR LOSS LEFT FORELIMB 11-25-13 7:52 2 HAIR LOSS RIGHT FORELIMB 11-25-13 7:52 1 HAIR LOSS LEFT FORELIMB 11-26-13 7:20 1 HAIR LOSS RIGHT FORELIMB 11-26-13 7:20 1 HAIR LOSS LEFT FORELIMB 91628 F 100 PPM NORMAL 10-14-13 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-24-13 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-05-13

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----------------------------------------------------------------------------------------------------------------------------------- 91628 F 100 PPM DISPOSITION 11-24-13 9:00 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91631 F 100 PPM NORMAL 10-14-13 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-24-13 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91631 F 100 PPM DISPOSITION 11-24-13 9:00 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91631 F 100 PPM BODY/INTEGUMENT 11-18-13 7:59 1 HAIR LOSS RIGHT FORELIMB 11-18-13 7:59 1 HAIR LOSS LEFT FORELIMB 91636 F 100 PPM NORMAL 10-14-13 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-25-13 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91636 F 100 PPM DISPOSITION 11-25-13 8:53 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91649 F 100 PPM NORMAL 10-14-13 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 8:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 8:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91649 F 100 PPM DISPOSITION 11-23-13 10:46 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91650 F 100 PPM NORMAL 10-14-13 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-05-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91650 F 100 PPM NORMAL 10-28-13 8:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 8:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91650 F 100 PPM DISPOSITION 11-23-13 10:46 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91656 F 100 PPM NORMAL 10-14-13 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 8:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91656 F 100 PPM DISPOSITION 11-28-13 8:36 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91656 F 100 PPM BODY/INTEGUMENT 11-25-13 7:54 1 HAIR LOSS LEFT FORELIMB 11-28-13 7:02 2 HAIR LOSS LEFT FORELIMB 11-28-13 7:02 1 HAIR LOSS RIGHT FORELIMB 91671 F 100 PPM NORMAL 10-14-13 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-25-13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-28-13 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91671 F 100 PPM DISPOSITION 11-28-13 8:37 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91675 F 100 PPM NORMAL 10-14-13 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 8:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-05-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91675 F 100 PPM NORMAL 11-18-13 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-24-13 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91675 F 100 PPM DISPOSITION 11-24-13 9:00 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91675 F 100 PPM EYES/EARS/NOSE 11-10-13 7:34 1 DRIED RED MATERIAL AROUND NOSE 91677 F 100 PPM NORMAL 10-14-13 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91677 F 100 PPM DISPOSITION 11-25-13 8:53 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91677 F 100 PPM BODY/INTEGUMENT 11-18-13 8:01 3 HAIR LOSS RIGHT FORELIMB 11-18-13 8:01 3 HAIR LOSS LEFT FORELIMB 11-25-13 7:56 3 HAIR LOSS RIGHT FORELIMB 11-25-13 7:56 3 HAIR LOSS LEFT FORELIMB 91679 F 100 PPM NORMAL 10-14-13 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 8:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91679 F 100 PPM DISPOSITION 11-23-13 10:47 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91684 F 100 PPM NORMAL 10-14-13 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-24-13 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-05-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91684 F 100 PPM DISPOSITION 11-24-13 9:01 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91622 F 175 PPM NORMAL 10-14-13 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91622 F 175 PPM DISPOSITION 11-23-13 10:47 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91622 F 175 PPM BODY/INTEGUMENT 10-21-13 6:54 2 HAIR LOSS RIGHT FORELIMB 10-21-13 6:54 2 HAIR LOSS LEFT FORELIMB 10-27-13 6:30 1 HAIR LOSS RIGHT FORELIMB 10-27-13 6:30 1 HAIR LOSS LEFT FORELIMB 10-28-13 9:00 1 HAIR LOSS RIGHT FORELIMB 10-28-13 9:00 1 HAIR LOSS LEFT FORELIMB 11-04-13 7:32 1 HAIR LOSS RIGHT FORELIMB 11-04-13 7:32 1 HAIR LOSS LEFT FORELIMB 11-10-13 7:36 1 HAIR LOSS RIGHT FORELIMB 11-10-13 7:36 1 HAIR LOSS LEFT FORELIMB 11-18-13 8:03 3 HAIR LOSS RIGHT FORELIMB 11-18-13 8:03 3 HAIR LOSS LEFT FORELIMB 91623 F 175 PPM NORMAL 10-14-13 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 8:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-25-13 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 12-02-13 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 12-05-13 8:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91623 F 175 PPM DISPOSITION 12-05-13 8:59 P SCHEDULED EUTHANASIA; POST-COHABITATION DAY 25 91623 F 175 PPM SPECIAL II 11-10-13 16:55 P BREEDING PERIOD COMPLETE; FEMALE SEPARATED FROM MALE AND PLACED INTO CLEAN CAGING 91626 F 175 PPM NORMAL 10-14-13 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-05-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91626 F 175 PPM NORMAL 10-27-13 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 8:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-25-13 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-26-13 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91626 F 175 PPM DISPOSITION 11-26-13 8:45 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91643 F 175 PPM NORMAL 10-14-13 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 8:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-25-13 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-29-13 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91643 F 175 PPM DISPOSITION 11-29-13 7:36 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91654 F 175 PPM NORMAL 10-14-13 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-25-13 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-27-13 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91654 F 175 PPM DISPOSITION 11-27-13 8:27 P SCHEDULED EUTHANASIA; TOTAL LITTER LOSS 91657 F 175 PPM NORMAL 10-14-13 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-05-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91657 F 175 PPM NORMAL 11-10-13 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-25-13 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 12-02-13 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 12-04-13 7:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91657 F 175 PPM DISPOSITION 12-04-13 10:01 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91662 F 175 PPM NORMAL 10-14-13 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-25-13 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-26-13 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91662 F 175 PPM DISPOSITION 11-26-13 8:46 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91666 F 175 PPM NORMAL 10-14-13 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 9:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-24-13 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91666 F 175 PPM DISPOSITION 11-24-13 9:01 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91676 F 175 PPM NORMAL 10-14-13 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-05-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91676 F 175 PPM NORMAL 11-18-13 8:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-25-13 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91676 F 175 PPM DISPOSITION 11-25-13 8:53 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91678 F 175 PPM NORMAL 10-14-13 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 9:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 8:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-24-13 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91678 F 175 PPM DISPOSITION 11-24-13 9:01 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91681 F 175 PPM NORMAL 10-14-13 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 8:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-25-13 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 12-02-13 7:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 12-03-13 7:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91681 F 175 PPM DISPOSITION 12-03-13 8:43 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91681 F 175 PPM EYES/EARS/NOSE 11-10-13 7:38 1 DRIED RED MATERIAL AROUND NOSE 91682 F 175 PPM NORMAL 10-14-13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91682 F 175 PPM DISPOSITION 11-26-13 8:46 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91682 F 175 PPM BODY/INTEGUMENT 11-18-13 8:06 2 HAIR LOSS RIGHT FORELIMB

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TABLE RANGE: 10-14-13 TO 12-05-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91682 F 175 PPM BODY/INTEGUMENT 11-18-13 8:06 3 HAIR LOSS LEFT FORELIMB 11-25-13 8:10 3 HAIR LOSS RIGHT FORELIMB 11-25-13 8:10 3 HAIR LOSS LEFT FORELIMB 11-26-13 7:25 3 HAIR LOSS RIGHT FORELIMB 11-26-13 7:25 3 HAIR LOSS LEFT FORELIMB 91624 F 10000 PPM NORMAL 10-14-13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 8:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-25-13 8:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91624 F 10000 PPM DISPOSITION 11-25-13 8:53 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91625 F 10000 PPM NORMAL 10-14-13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 8:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-25-13 8:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-26-13 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91625 F 10000 PPM DISPOSITION 11-26-13 8:47 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91627 F 10000 PPM NORMAL 10-14-13 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 9:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 8:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-05-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91627 F 10000 PPM DISPOSITION 11-23-13 10:47 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91634 F 10000 PPM NORMAL 10-14-13 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 8:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-25-13 8:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-26-13 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91634 F 10000 PPM DISPOSITION 11-26-13 8:48 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91635 F 10000 PPM DISPOSITION 11-23-13 10:48 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91635 F 10000 PPM BODY/INTEGUMENT 10-14-13 7:56 1 HAIR LOSS RIGHT FORELIMB 10-14-13 7:56 1 HAIR LOSS LEFT FORELIMB 10-21-13 7:02 1 HAIR LOSS RIGHT FORELIMB 10-21-13 7:02 1 HAIR LOSS LEFT FORELIMB 10-27-13 6:34 1 HAIR LOSS RIGHT FORELIMB 10-27-13 6:34 1 HAIR LOSS LEFT FORELIMB 10-28-13 9:01 1 HAIR LOSS RIGHT FORELIMB 10-28-13 9:01 1 HAIR LOSS LEFT FORELIMB 11-04-13 7:36 1 HAIR LOSS RIGHT FORELIMB 11-04-13 7:36 1 HAIR LOSS LEFT FORELIMB 11-10-13 7:40 1 HAIR LOSS RIGHT FORELIMB 11-10-13 7:40 1 HAIR LOSS LEFT FORELIMB 11-18-13 8:08 3 HAIR LOSS RIGHT FORELIMB 11-18-13 8:08 2 HAIR LOSS LEFT FORELIMB 91638 F 10000 PPM NORMAL 10-14-13 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-05-13

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----------------------------------------------------------------------------------------------------------------------------------- 91638 F 10000 PPM NORMAL 11-10-13 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 8:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91638 F 10000 PPM DISPOSITION 11-25-13 8:53 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91638 F 10000 PPM BODY/INTEGUMENT 11-25-13 8:15 1 HAIR LOSS LEFT FORELIMB 91652 F 10000 PPM NORMAL 10-14-13 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91652 F 10000 PPM DISPOSITION 11-23-13 10:48 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91652 F 10000 PPM BODY/INTEGUMENT 10-21-13 7:03 2 HAIR LOSS RIGHT FORELIMB 10-21-13 7:03 2 HAIR LOSS LEFT FORELIMB 10-27-13 6:34 1 HAIR LOSS RIGHT FORELIMB 10-27-13 6:34 1 HAIR LOSS LEFT FORELIMB 10-28-13 9:02 1 HAIR LOSS RIGHT FORELIMB 10-28-13 9:02 1 HAIR LOSS LEFT FORELIMB 11-04-13 7:36 2 HAIR LOSS RIGHT FORELIMB 11-04-13 7:36 1 HAIR LOSS LEFT FORELIMB 11-10-13 7:41 2 HAIR LOSS RIGHT FORELIMB 11-10-13 7:41 1 HAIR LOSS LEFT FORELIMB 11-18-13 8:09 3 HAIR LOSS RIGHT FORELIMB 11-18-13 8:09 3 HAIR LOSS LEFT FORELIMB 91655 F 10000 PPM NORMAL 10-14-13 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91655 F 10000 PPM DISPOSITION 11-23-13 10:48 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91655 F 10000 PPM BODY/INTEGUMENT 10-21-13 7:05 1 HAIR LOSS VENTRAL ABDOMINAL AREA 10-21-13 7:05 1 HAIR LOSS RIGHT INGUINAL AREA 10-21-13 7:05 1 HAIR LOSS LEFT INGUINAL AREA 10-21-13 7:05 1 HAIR LOSS LEFT HINDLIMB 10-27-13 6:35 1 HAIR LOSS VENTRAL ABDOMINAL AREA 10-27-13 6:35 1 HAIR LOSS RIGHT INGUINAL AREA 10-27-13 6:35 1 HAIR LOSS LEFT INGUINAL AREA 10-27-13 6:35 1 HAIR LOSS LEFT HINDLIMB

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TABLE RANGE: 10-14-13 TO 12-05-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91655 F 10000 PPM BODY/INTEGUMENT 10-28-13 9:02 1 HAIR LOSS LEFT HINDLIMB 10-28-13 9:02 1 HAIR LOSS VENTRAL ABDOMINAL AREA 10-28-13 9:03 1 HAIR LOSS LEFT INGUINAL AREA 10-28-13 9:03 1 HAIR LOSS RIGHT INGUINAL AREA 11-04-13 7:37 1 HAIR LOSS RIGHT INGUINAL AREA 11-04-13 7:37 1 HAIR LOSS LEFT INGUINAL AREA 11-04-13 7:37 1 HAIR LOSS LEFT HINDLIMB 11-04-13 7:37 1 HAIR LOSS RIGHT HINDLIMB 11-04-13 7:37 1 HAIR LOSS VENTRAL ABDOMINAL AREA 11-18-13 8:09 3 HAIR LOSS RIGHT HINDLIMB 11-18-13 8:09 2 HAIR LOSS LEFT HINDLIMB 11-18-13 8:10 2 HAIR LOSS VENTRAL ABDOMINAL AREA 91658 F 10000 PPM NORMAL 10-14-13 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91658 F 10000 PPM DISPOSITION 11-24-13 9:01 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91658 F 10000 PPM BODY/INTEGUMENT 11-10-13 7:42 2 HAIR LOSS RIGHT FORELIMB 11-10-13 7:42 2 HAIR LOSS LEFT FORELIMB 11-18-13 8:10 3 HAIR LOSS RIGHT FORELIMB 11-18-13 8:10 3 HAIR LOSS LEFT FORELIMB 11-24-13 7:26 3 HAIR LOSS RIGHT FORELIMB 11-24-13 7:26 3 HAIR LOSS LEFT FORELIMB 11-24-13 7:26 2 HAIR LOSS RIGHT HINDLIMB 91667 F 10000 PPM NORMAL 10-14-13 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 425 of 1107**TABLE A5 (F0 FEMALES - DETAILED PHYSICAL EXAMINATIONS)

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TABLE RANGE: 10-14-13 TO 12-05-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91667 F 10000 PPM NORMAL 11-18-13 8:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-24-13 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91667 F 10000 PPM DISPOSITION 11-24-13 9:02 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91668 F 10000 PPM NORMAL 10-14-13 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91668 F 10000 PPM DISPOSITION 11-24-13 9:02 P SCHEDULED EUTHANASIA; LACTATION DAY 4 91668 F 10000 PPM BODY/INTEGUMENT 10-21-13 7:06 1 HAIR LOSS RIGHT FORELIMB 10-21-13 7:06 1 HAIR LOSS LEFT FORELIMB 10-27-13 6:36 1 HAIR LOSS RIGHT FORELIMB 10-27-13 6:36 1 HAIR LOSS LEFT FORELIMB 11-04-13 7:38 1 HAIR LOSS RIGHT FORELIMB 11-04-13 7:38 1 HAIR LOSS LEFT FORELIMB 11-10-13 7:42 1 HAIR LOSS RIGHT FORELIMB 11-10-13 7:42 1 HAIR LOSS LEFT FORELIMB 11-18-13 8:11 3 HAIR LOSS RIGHT FORELIMB 11-18-13 8:11 3 HAIR LOSS LEFT FORELIMB 11-24-13 7:27 2 HAIR LOSS RIGHT FORELIMB 11-24-13 7:27 2 HAIR LOSS LEFT FORELIMB 91680 F 10000 PPM NORMAL 10-14-13 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 7:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 9:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 8:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91680 F 10000 PPM DISPOSITION 11-23-13 10:48 P SCHEDULED EUTHANASIA; LACTATION DAY 4

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PCRDv4.18 01/29/2014**Page 426 of 1107**TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91624 F 10000 PPM NORMAL 10-15-13 12:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 12:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 13:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91624 F 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY 91624 F 10000 PPM BODY/INTEGUMENT 10-17-13 11:46 1 WET CLEAR MATERIAL RIGHT FORELIMB 10-30-13 12:32 1 WET CLEAR MATERIAL RIGHT FORELIMB 10-30-13 12:32 1 WET CLEAR MATERIAL LEFT FORELIMB 10-30-13 12:32 1 WET CLEAR MATERIAL VENTRAL NECK 91624 F 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION 91624 F 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P LACRIMATION 10-14-13 13:26 P EYELIDS COMPLETELY SHUT 10-17-13 11:45 1 WET RED MATERIAL AROUND NOSE 10-31-13 11:56 2 WET RED MATERIAL AROUND NOSE 11-02-13 11:41 1 WET RED MATERIAL AROUND NOSE 11-17-13 11:48 1 DRIED RED MATERIAL AROUND NOSE 91624 F 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION 10-17-13 11:45 1 SALIVATION 10-17-13 11:45 1 WET CLEAR MATERIAL AROUND MOUTH 10-18-13 11:52 2 WET CLEAR MATERIAL AROUND MOUTH 10-19-13 11:29 2 SALIVATION 10-19-13 11:29 1 WET CLEAR MATERIAL AROUND MOUTH 10-20-13 11:23 2 SALIVATION 10-20-13 11:23 2 WET CLEAR MATERIAL AROUND MOUTH 10-21-13 12:42 1 SALIVATION 10-22-13 11:58 1 SALIVATION 10-23-13 11:53 2 SALIVATION 10-23-13 11:53 3 WET CLEAR MATERIAL AROUND MOUTH 10-24-13 13:43 1 SALIVATION 10-25-13 14:14 1 SALIVATION

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TABLE RANGE: 10-14-13 TO 11-20-13

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----------------------------------------------------------------------------------------------------------------------------------- 91624 F 10000 PPM ORAL/DENTAL 10-26-13 11:59 1 WET CLEAR MATERIAL AROUND MOUTH 10-27-13 11:50 1 SALIVATION 10-28-13 13:01 3 WET CLEAR MATERIAL AROUND MOUTH 10-28-13 13:01 3 SALIVATION 10-29-13 12:33 3 WET CLEAR MATERIAL AROUND MOUTH 10-29-13 12:33 2 SALIVATION 10-30-13 12:32 2 WET CLEAR MATERIAL AROUND MOUTH 10-31-13 11:56 2 SALIVATION 10-31-13 11:56 2 WET CLEAR MATERIAL AROUND MOUTH 11-01-13 11:43 2 WET CLEAR MATERIAL AROUND MOUTH 11-01-13 11:43 1 SALIVATION 11-02-13 11:41 2 SALIVATION 11-02-13 11:41 2 WET CLEAR MATERIAL AROUND MOUTH 11-03-13 11:22 2 WET CLEAR MATERIAL AROUND MOUTH 11-04-13 12:10 1 WET CLEAR MATERIAL AROUND MOUTH 11-04-13 12:10 1 SALIVATION 11-05-13 11:27 1 WET CLEAR MATERIAL AROUND MOUTH 11-06-13 11:49 1 WET CLEAR MATERIAL AROUND MOUTH 11-06-13 11:49 1 SALIVATION 11-07-13 12:03 1 WET CLEAR MATERIAL AROUND MOUTH 11-07-13 12:03 1 SALIVATION 11-08-13 13:07 1 SALIVATION 11-09-13 11:58 1 SALIVATION 11-11-13 12:47 1 WET CLEAR MATERIAL AROUND MOUTH 11-12-13 11:36 2 WET CLEAR MATERIAL AROUND MOUTH 11-12-13 11:36 1 SALIVATION 11-13-13 11:42 1 WET CLEAR MATERIAL AROUND MOUTH 11-13-13 11:42 1 SALIVATION 11-14-13 13:01 2 SALIVATION

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91624 F 10000 PPM ORAL/DENTAL 11-14-13 13:01 2 WET CLEAR MATERIAL AROUND MOUTH 11-15-13 12:00 2 WET CLEAR MATERIAL AROUND MOUTH 11-15-13 12:00 2 SALIVATION 11-16-13 11:44 P SALIVATION 11-17-13 11:48 1 SALIVATION 11-18-13 12:42 1 WET CLEAR MATERIAL AROUND MOUTH 11-18-13 12:42 1 SALIVATION 11-19-13 11:56 2 SALIVATION 11-19-13 11:56 1 WET CLEAR MATERIAL AROUND MOUTH 91625 F 10000 PPM NORMAL 10-22-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91625 F 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY 91625 F 10000 PPM BODY/INTEGUMENT 10-21-13 12:40 1 WET CLEAR MATERIAL RIGHT FORELIMB 10-21-13 12:40 1 WET CLEAR MATERIAL LEFT FORELIMB 10-29-13 12:31 3 WET CLEAR MATERIAL VENTRAL NECK 10-30-13 12:29 1 WET CLEAR MATERIAL RIGHT FORELIMB 10-30-13 12:29 2 WET CLEAR MATERIAL LEFT FORELIMB 10-30-13 12:29 2 WET CLEAR MATERIAL VENTRAL NECK 11-05-13 11:25 3 WET CLEAR MATERIAL VENTRAL NECK 11-05-13 11:25 3 WET CLEAR MATERIAL LEFT FORELIMB 11-05-13 11:25 3 WET CLEAR MATERIAL RIGHT FORELIMB 11-06-13 11:47 3 WET CLEAR MATERIAL VENTRAL NECK 11-06-13 11:47 2 WET CLEAR MATERIAL LEFT FORELIMB 11-06-13 11:47 2 WET CLEAR MATERIAL RIGHT FORELIMB 11-07-13 12:01 3 WET CLEAR MATERIAL VENTRAL NECK 11-07-13 12:01 3 WET CLEAR MATERIAL LEFT FORELIMB 11-07-13 12:01 3 WET CLEAR MATERIAL RIGHT FORELIMB 11-08-13 13:05 3 WET CLEAR MATERIAL VENTRAL NECK 11-10-13 13:08 1 WET CLEAR MATERIAL LEFT FORELIMB 11-10-13 13:08 1 WET CLEAR MATERIAL RIGHT FORELIMB

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91625 F 10000 PPM BODY/INTEGUMENT 11-11-13 12:45 3 WET CLEAR MATERIAL VENTRAL NECK 11-11-13 12:45 3 WET CLEAR MATERIAL LEFT FORELIMB 11-11-13 12:45 3 WET CLEAR MATERIAL RIGHT FORELIMB 11-12-13 11:33 3 WET CLEAR MATERIAL VENTRAL NECK 11-12-13 11:34 3 WET CLEAR MATERIAL LEFT FORELIMB 11-12-13 11:34 3 WET CLEAR MATERIAL RIGHT FORELIMB 11-13-13 11:40 2 WET CLEAR MATERIAL VENTRAL NECK 11-13-13 11:40 2 WET CLEAR MATERIAL LEFT FORELIMB 11-13-13 11:40 2 WET CLEAR MATERIAL RIGHT FORELIMB 11-14-13 12:59 2 WET CLEAR MATERIAL VENTRAL NECK 11-15-13 11:58 3 WET CLEAR MATERIAL VENTRAL NECK 11-15-13 11:58 2 WET CLEAR MATERIAL LEFT FORELIMB 11-15-13 11:58 2 WET CLEAR MATERIAL RIGHT FORELIMB 11-18-13 12:41 2 WET CLEAR MATERIAL VENTRAL NECK 11-19-13 11:55 3 WET CLEAR MATERIAL VENTRAL NECK 11-19-13 11:55 3 WET CLEAR MATERIAL RIGHT FORELIMB 11-19-13 11:55 3 WET CLEAR MATERIAL LEFT FORELIMB 91625 F 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION 91625 F 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT 10-14-13 13:26 P LACRIMATION 10-17-13 11:43 1 WET RED MATERIAL AROUND NOSE 10-18-13 11:50 3 WET RED MATERIAL AROUND NOSE 10-20-13 11:22 1 LACRIMATION RIGHT EYE 10-20-13 11:22 1 WET RED MATERIAL AROUND NOSE 11-03-13 11:19 2 WET RED MATERIAL AROUND NOSE 11-07-13 12:01 1 WET RED MATERIAL AROUND NOSE 11-17-13 11:46 1 WET RED MATERIAL AROUND NOSE 91625 F 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION 10-15-13 12:29 1 WET CLEAR MATERIAL AROUND MOUTH

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 430 of 1107**TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91625 F 10000 PPM ORAL/DENTAL 10-16-13 12:20 1 WET CLEAR MATERIAL AROUND MOUTH 10-17-13 11:42 2 WET CLEAR MATERIAL AROUND MOUTH 10-17-13 11:42 2 SALIVATION 10-18-13 11:50 3 SALIVATION 10-18-13 11:50 3 WET CLEAR MATERIAL AROUND MOUTH 10-19-13 11:27 1 SALIVATION 10-19-13 11:27 3 WET CLEAR MATERIAL AROUND MOUTH 10-20-13 11:22 1 SALIVATION 10-20-13 11:22 2 WET CLEAR MATERIAL AROUND MOUTH 10-21-13 12:39 2 SALIVATION 10-21-13 12:40 2 WET CLEAR MATERIAL AROUND MOUTH 10-23-13 11:51 2 SALIVATION 10-23-13 11:51 3 WET CLEAR MATERIAL AROUND MOUTH 10-24-13 13:42 1 WET CLEAR MATERIAL AROUND MOUTH 10-25-13 14:13 1 WET CLEAR MATERIAL AROUND MOUTH 10-26-13 11:56 2 WET CLEAR MATERIAL AROUND MOUTH 10-27-13 11:49 1 SALIVATION 10-28-13 12:58 3 WET CLEAR MATERIAL AROUND MOUTH 10-28-13 12:58 3 SALIVATION 10-29-13 12:31 3 WET CLEAR MATERIAL AROUND MOUTH 10-29-13 12:31 3 SALIVATION 10-30-13 12:29 3 WET CLEAR MATERIAL AROUND MOUTH 10-31-13 11:54 2 WET CLEAR MATERIAL AROUND MOUTH 10-31-13 11:54 2 SALIVATION 11-01-13 11:40 3 WET CLEAR MATERIAL AROUND MOUTH 11-01-13 11:40 1 SALIVATION 11-02-13 11:38 3 WET CLEAR MATERIAL AROUND MOUTH 11-02-13 11:38 1 SALIVATION 11-03-13 11:19 3 WET CLEAR MATERIAL AROUND MOUTH

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 431 of 1107**TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91625 F 10000 PPM ORAL/DENTAL 11-03-13 11:19 2 SALIVATION 11-04-13 12:08 3 WET CLEAR MATERIAL AROUND MOUTH 11-04-13 12:08 2 SALIVATION 11-05-13 11:25 3 WET CLEAR MATERIAL AROUND MOUTH 11-05-13 11:25 1 SALIVATION 11-06-13 11:47 3 WET CLEAR MATERIAL AROUND MOUTH 11-06-13 11:47 3 SALIVATION 11-07-13 12:01 3 WET CLEAR MATERIAL AROUND MOUTH 11-07-13 12:01 2 SALIVATION 11-08-13 13:05 3 WET CLEAR MATERIAL AROUND MOUTH 11-08-13 13:05 3 SALIVATION 11-09-13 11:56 2 SALIVATION 11-10-13 13:08 2 SALIVATION 11-10-13 13:08 2 WET CLEAR MATERIAL AROUND MOUTH 11-11-13 12:45 3 WET CLEAR MATERIAL AROUND MOUTH 11-11-13 12:45 3 SALIVATION 11-12-13 11:34 3 WET CLEAR MATERIAL AROUND MOUTH 11-13-13 11:40 3 WET CLEAR MATERIAL AROUND MOUTH 11-14-13 12:59 3 WET CLEAR MATERIAL AROUND MOUTH 11-14-13 12:59 1 SALIVATION 11-15-13 11:58 3 WET CLEAR MATERIAL AROUND MOUTH 11-15-13 11:58 1 SALIVATION 11-16-13 11:42 2 WET CLEAR MATERIAL AROUND MOUTH 11-17-13 11:46 2 WET CLEAR MATERIAL AROUND MOUTH 11-18-13 12:41 3 WET CLEAR MATERIAL AROUND MOUTH 11-18-13 12:41 3 SALIVATION 11-19-13 11:55 3 WET CLEAR MATERIAL AROUND MOUTH 11-19-13 11:55 2 SALIVATION 91627 F 10000 PPM NORMAL 10-15-13 12:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 432 of 1107**TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91627 F 10000 PPM NORMAL 10-16-13 12:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 11:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 11:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 11:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 11:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 12:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 13:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 11:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 13:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 11:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 11:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 11:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 12:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 11:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 11:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91627 F 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY 91627 F 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION 91627 F 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT 10-14-13 13:26 P LACRIMATION 91627 F 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION 10-23-13 11:54 1 WET RED MATERIAL AROUND MOUTH 10-30-13 12:31 1 WET CLEAR MATERIAL AROUND MOUTH 11-03-13 11:21 2 WET CLEAR MATERIAL AROUND MOUTH

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 433 of 1107**TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

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TABLE RANGE: 10-14-13 TO 11-20-13

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----------------------------------------------------------------------------------------------------------------------------------- 91627 F 10000 PPM ORAL/DENTAL 11-07-13 12:02 2 WET CLEAR MATERIAL AROUND MOUTH 11-09-13 11:57 1 WET CLEAR MATERIAL AROUND MOUTH 11-10-13 13:10 1 WET CLEAR MATERIAL AROUND MOUTH 11-11-13 12:46 3 WET CLEAR MATERIAL AROUND MOUTH 11-12-13 11:35 3 WET CLEAR MATERIAL AROUND MOUTH 11-13-13 11:41 1 WET CLEAR MATERIAL AROUND MOUTH 11-14-13 13:00 1 WET CLEAR MATERIAL AROUND MOUTH 11-15-13 11:59 2 WET CLEAR MATERIAL AROUND MOUTH 11-17-13 11:50 2 WET CLEAR MATERIAL AROUND MOUTH 91634 F 10000 PPM NORMAL 10-15-13 12:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 11:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 11:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 12:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 12:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 13:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 12:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91634 F 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY 91634 F 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION 91634 F 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT 10-14-13 13:26 P LACRIMATION 10-18-13 11:48 1 DRIED RED MATERIAL AROUND NOSE 11-17-13 11:51 1 WET RED MATERIAL AROUND NOSE 91634 F 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION 10-23-13 11:55 1 SALIVATION 10-23-13 11:55 2 WET CLEAR MATERIAL AROUND MOUTH 10-27-13 11:51 1 SALIVATION

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 434 of 1107**TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91634 F 10000 PPM ORAL/DENTAL 10-28-13 12:59 2 SALIVATION 10-28-13 12:59 2 WET CLEAR MATERIAL AROUND MOUTH 10-29-13 12:32 3 WET CLEAR MATERIAL AROUND MOUTH 10-29-13 12:32 2 SALIVATION 10-31-13 11:54 2 WET CLEAR MATERIAL AROUND MOUTH 11-01-13 11:41 1 WET CLEAR MATERIAL AROUND MOUTH 11-01-13 11:41 1 SALIVATION 11-02-13 11:39 3 WET CLEAR MATERIAL AROUND MOUTH 11-03-13 11:21 1 WET CLEAR MATERIAL AROUND MOUTH 11-04-13 12:09 1 WET CLEAR MATERIAL AROUND MOUTH 11-05-13 11:26 2 WET CLEAR MATERIAL AROUND MOUTH 11-06-13 11:48 1 WET RED MATERIAL AROUND MOUTH 11-07-13 12:02 2 WET CLEAR MATERIAL AROUND MOUTH 11-07-13 12:02 2 SALIVATION 11-08-13 13:06 1 WET CLEAR MATERIAL AROUND MOUTH 11-08-13 13:06 1 SALIVATION 11-09-13 11:57 1 WET RED MATERIAL AROUND MOUTH 11-10-13 13:09 1 SALIVATION 11-11-13 12:46 2 WET CLEAR MATERIAL AROUND MOUTH 11-11-13 12:46 1 SALIVATION 11-12-13 11:35 2 WET CLEAR MATERIAL AROUND MOUTH 11-13-13 11:41 2 WET CLEAR MATERIAL AROUND MOUTH 11-14-13 13:00 1 WET CLEAR MATERIAL AROUND MOUTH 11-15-13 11:59 1 WET CLEAR MATERIAL AROUND MOUTH 11-16-13 11:46 1 WET CLEAR MATERIAL AROUND MOUTH 11-17-13 11:51 1 WET CLEAR MATERIAL AROUND MOUTH 11-18-13 12:42 1 SALIVATION 11-18-13 12:42 1 WET CLEAR MATERIAL AROUND MOUTH 11-19-13 11:55 2 WET CLEAR MATERIAL AROUND MOUTH

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91634 F 10000 PPM ORAL/DENTAL 11-20-13 12:37 2 WET CLEAR MATERIAL AROUND MOUTH 11-20-13 12:37 2 SALIVATION 91635 F 10000 PPM NORMAL 10-15-13 12:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 12:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 11:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 11:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 11:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 11:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 12:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 13:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 14:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 11:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 12:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 11:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91635 F 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY 91635 F 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION 91635 F 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT 10-14-13 13:26 P LACRIMATION 11-01-13 11:41 2 WET RED MATERIAL AROUND NOSE 91635 F 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION 10-23-13 11:50 1 WET CLEAR MATERIAL AROUND MOUTH 10-27-13 11:49 1 WET CLEAR MATERIAL AROUND MOUTH 10-28-13 12:58 3 WET CLEAR MATERIAL AROUND MOUTH 10-28-13 12:58 3 SALIVATION 10-29-13 12:31 2 WET CLEAR MATERIAL AROUND MOUTH 10-31-13 11:54 2 WET CLEAR MATERIAL AROUND MOUTH 10-31-13 11:54 2 SALIVATION

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91635 F 10000 PPM ORAL/DENTAL 11-03-13 11:19 3 WET CLEAR MATERIAL AROUND MOUTH 11-03-13 11:19 1 SALIVATION 11-04-13 12:08 2 WET CLEAR MATERIAL AROUND MOUTH 11-04-13 12:08 1 SALIVATION 11-05-13 11:26 3 WET CLEAR MATERIAL AROUND MOUTH 11-06-13 11:47 2 WET CLEAR MATERIAL AROUND MOUTH 11-06-13 11:47 2 SALIVATION 11-07-13 12:01 2 WET CLEAR MATERIAL AROUND MOUTH 11-07-13 12:01 2 SALIVATION 11-08-13 13:05 3 WET CLEAR MATERIAL AROUND MOUTH 11-09-13 11:56 1 SALIVATION 11-10-13 13:08 1 SALIVATION 11-11-13 12:45 3 WET CLEAR MATERIAL AROUND MOUTH 11-11-13 12:45 2 SALIVATION 11-12-13 11:34 3 WET CLEAR MATERIAL AROUND MOUTH 11-13-13 11:40 3 WET CLEAR MATERIAL AROUND MOUTH 11-14-13 12:59 3 WET CLEAR MATERIAL AROUND MOUTH 11-16-13 11:42 1 WET CLEAR MATERIAL AROUND MOUTH 11-17-13 11:45 1 SALIVATION 91638 F 10000 PPM NORMAL 10-15-13 12:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 12:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 11:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 11:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 11:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 12:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 13:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 14:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 11:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91638 F 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY 91638 F 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION 91638 F 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT 10-14-13 13:26 P LACRIMATION 10-28-13 12:59 2 DRIED RED MATERIAL AROUND NOSE 10-29-13 12:31 2 DRIED RED MATERIAL AROUND NOSE 11-06-13 11:48 1 WET RED MATERIAL AROUND NOSE 11-10-13 13:07 1 WET RED MATERIAL AROUND NOSE 11-17-13 11:45 1 DRIED RED MATERIAL AROUND NOSE 91638 F 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION 10-20-13 11:21 1 WET CLEAR MATERIAL AROUND MOUTH 10-23-13 11:49 1 WET RED MATERIAL AROUND MOUTH 10-27-13 11:49 1 WET CLEAR MATERIAL AROUND MOUTH 10-28-13 12:59 1 SALIVATION 10-28-13 12:59 1 WET CLEAR MATERIAL AROUND MOUTH 10-30-13 12:29 1 WET CLEAR MATERIAL AROUND MOUTH 10-31-13 11:54 2 WET CLEAR MATERIAL AROUND MOUTH 10-31-13 11:54 2 SALIVATION 11-01-13 11:41 2 WET CLEAR MATERIAL AROUND MOUTH 11-01-13 11:41 1 SALIVATION 11-02-13 11:38 2 WET CLEAR MATERIAL AROUND MOUTH 11-02-13 11:39 1 SALIVATION 11-03-13 11:19 1 WET CLEAR MATERIAL AROUND MOUTH 11-04-13 12:09 2 WET CLEAR MATERIAL AROUND MOUTH 11-04-13 12:09 1 SALIVATION 11-05-13 11:26 3 WET CLEAR MATERIAL AROUND MOUTH 11-06-13 11:48 2 WET CLEAR MATERIAL AROUND MOUTH 11-06-13 11:48 1 SALIVATION 11-07-13 12:01 1 WET CLEAR MATERIAL AROUND MOUTH

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91638 F 10000 PPM ORAL/DENTAL 11-07-13 12:01 1 SALIVATION 11-08-13 13:05 3 WET CLEAR MATERIAL AROUND MOUTH 11-09-13 11:56 1 WET RED MATERIAL AROUND MOUTH 11-11-13 12:46 3 WET CLEAR MATERIAL AROUND MOUTH 11-12-13 11:34 3 WET CLEAR MATERIAL AROUND MOUTH 11-13-13 11:40 3 WET CLEAR MATERIAL AROUND MOUTH 11-13-13 11:40 1 SALIVATION 11-14-13 12:59 2 WET CLEAR MATERIAL AROUND MOUTH 11-15-13 11:58 2 WET CLEAR MATERIAL AROUND MOUTH 11-15-13 11:58 1 SALIVATION 11-16-13 11:42 1 WET CLEAR MATERIAL AROUND MOUTH 11-17-13 11:45 2 SALIVATION 11-18-13 12:41 2 WET CLEAR MATERIAL AROUND MOUTH 11-18-13 12:41 1 SALIVATION 11-19-13 11:55 3 WET CLEAR MATERIAL AROUND MOUTH 11-19-13 11:55 3 SALIVATION 91652 F 10000 PPM NORMAL 10-15-13 12:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 12:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 11:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 11:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 12:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 11:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 13:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 11:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 439 of 1107**TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91652 F 10000 PPM NORMAL 10-30-13 12:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 11:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 12:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 11:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 11:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 13:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 11:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 11:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91652 F 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY 91652 F 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION 91652 F 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT 10-14-13 13:26 P LACRIMATION 91652 F 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION 10-28-13 13:00 3 SALIVATION 10-28-13 13:00 3 WET CLEAR MATERIAL AROUND MOUTH 10-29-13 12:32 1 WET RED MATERIAL AROUND MOUTH 11-01-13 11:42 1 WET CLEAR MATERIAL AROUND MOUTH 11-02-13 11:40 2 WET CLEAR MATERIAL AROUND MOUTH 11-03-13 11:21 2 WET CLEAR MATERIAL AROUND MOUTH 11-05-13 11:26 1 WET CLEAR MATERIAL AROUND MOUTH 11-08-13 13:06 1 WET CLEAR MATERIAL AROUND MOUTH 11-09-13 11:57 1 WET RED MATERIAL AROUND MOUTH 11-10-13 13:10 1 SALIVATION 11-11-13 12:46 1 WET CLEAR MATERIAL AROUND MOUTH 91655 F 10000 PPM NORMAL 10-15-13 12:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 12:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 440 of 1107**TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91655 F 10000 PPM NORMAL 10-17-13 11:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 11:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 11:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 11:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 13:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 14:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 11:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 11:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 12:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 13:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 11:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 12:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91655 F 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY 91655 F 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION 91655 F 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT 10-14-13 13:26 P LACRIMATION 11-12-13 11:33 2 WET RED MATERIAL AROUND NOSE 11-13-13 11:39 1 DRIED RED MATERIAL AROUND NOSE 11-15-13 11:57 2 WET RED MATERIAL AROUND NOSE 11-17-13 11:47 2 WET RED MATERIAL AROUND NOSE 91655 F 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION 10-28-13 12:58 3 SALIVATION 10-28-13 12:58 3 WET CLEAR MATERIAL AROUND MOUTH 10-29-13 12:30 1 WET RED MATERIAL AROUND MOUTH 10-30-13 12:30 1 SALIVATION

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 441 of 1107**TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91655 F 10000 PPM ORAL/DENTAL 10-31-13 11:53 2 WET CLEAR MATERIAL AROUND MOUTH 10-31-13 11:53 2 SALIVATION 11-01-13 11:40 2 WET CLEAR MATERIAL AROUND MOUTH 11-01-13 11:40 1 SALIVATION 11-03-13 11:18 1 WET RED MATERIAL AROUND MOUTH 11-05-13 11:24 1 WET CLEAR MATERIAL AROUND MOUTH 11-05-13 11:24 1 SALIVATION 11-06-13 11:46 1 WET CLEAR MATERIAL AROUND MOUTH 11-06-13 11:46 1 SALIVATION 11-07-13 12:00 2 WET CLEAR MATERIAL AROUND MOUTH 11-07-13 12:00 2 SALIVATION 11-10-13 13:09 1 WET CLEAR MATERIAL AROUND MOUTH 11-11-13 12:45 1 WET CLEAR MATERIAL AROUND MOUTH 11-12-13 11:33 1 WET RED MATERIAL AROUND MOUTH 11-15-13 11:57 2 WET RED MATERIAL AROUND MOUTH 11-16-13 11:44 1 DRIED RED MATERIAL AROUND MOUTH 11-17-13 11:47 1 WET CLEAR MATERIAL AROUND MOUTH 91658 F 10000 PPM NORMAL 10-15-13 12:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 12:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 11:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 11:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 11:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 13:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 11:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 12:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 11:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 442 of 1107**TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91658 F 10000 PPM NORMAL 11-06-13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91658 F 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY 91658 F 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION 91658 F 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT 10-14-13 13:26 P LACRIMATION 10-21-13 12:43 1 WET RED MATERIAL AROUND NOSE 10-23-13 11:53 1 WET RED MATERIAL AROUND NOSE 10-31-13 11:55 3 WET RED MATERIAL AROUND NOSE 11-13-13 11:42 2 DRIED RED MATERIAL AROUND NOSE 11-15-13 12:00 2 DRIED RED MATERIAL AROUND NOSE 11-17-13 11:49 1 WET RED MATERIAL AROUND NOSE 11-18-13 12:42 2 WET RED MATERIAL AROUND NOSE 91658 F 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION 10-20-13 11:24 2 WET CLEAR MATERIAL AROUND MOUTH 10-23-13 11:54 1 WET RED MATERIAL AROUND MOUTH 10-28-13 13:00 2 SALIVATION 10-28-13 13:00 3 WET CLEAR MATERIAL AROUND MOUTH 10-29-13 12:33 1 WET RED MATERIAL AROUND MOUTH 10-30-13 12:31 2 WET CLEAR MATERIAL AROUND MOUTH 10-31-13 11:55 2 WET RED MATERIAL AROUND MOUTH 11-01-13 11:42 2 WET CLEAR MATERIAL AROUND MOUTH 11-02-13 11:41 2 WET CLEAR MATERIAL AROUND MOUTH 11-03-13 11:22 1 WET CLEAR MATERIAL AROUND MOUTH 11-07-13 12:03 2 WET CLEAR MATERIAL AROUND MOUTH 11-08-13 13:07 1 WET CLEAR MATERIAL AROUND MOUTH 11-09-13 11:57 1 WET RED MATERIAL AROUND MOUTH 11-10-13 13:10 1 WET CLEAR MATERIAL AROUND MOUTH 11-11-13 12:47 2 WET CLEAR MATERIAL AROUND MOUTH 11-12-13 11:35 1 WET CLEAR MATERIAL AROUND MOUTH

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 443 of 1107**TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91658 F 10000 PPM ORAL/DENTAL 11-13-13 11:42 2 DRIED RED MATERIAL AROUND MOUTH 11-14-13 13:01 1 WET CLEAR MATERIAL AROUND MOUTH 11-16-13 11:45 1 DRIED RED MATERIAL AROUND MOUTH 11-17-13 11:49 1 WET CLEAR MATERIAL AROUND MOUTH 11-18-13 12:42 2 WET RED MATERIAL AROUND MOUTH 91667 F 10000 PPM NORMAL 10-15-13 12:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 11:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 11:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 11:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 11:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 13:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 14:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 11:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 12:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 12:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 11:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 12:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 11:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 11:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 13:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 13:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 11:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 12:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 444 of 1107**TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91667 F 10000 PPM NORMAL 11-15-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 11:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91667 F 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY 91667 F 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION 91667 F 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT 10-14-13 13:26 P LACRIMATION 10-18-13 11:48 1 WET RED MATERIAL AROUND NOSE 10-28-13 12:57 1 DRIED RED MATERIAL AROUND NOSE 11-18-13 12:40 1 WET RED MATERIAL AROUND NOSE 91667 F 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION 10-31-13 11:53 1 WET CLEAR MATERIAL AROUND MOUTH 11-01-13 11:39 3 WET CLEAR MATERIAL AROUND MOUTH 11-01-13 11:39 2 SALIVATION 11-03-13 11:18 1 WET CLEAR MATERIAL AROUND MOUTH 11-07-13 12:00 2 WET CLEAR MATERIAL AROUND MOUTH 11-07-13 12:00 2 SALIVATION 11-11-13 12:44 2 WET CLEAR MATERIAL AROUND MOUTH 11-17-13 11:48 1 WET CLEAR MATERIAL AROUND MOUTH 91668 F 10000 PPM NORMAL 10-15-13 12:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 12:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 11:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 11:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 11:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 13:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 11:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 445 of 1107**TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91668 F 10000 PPM NORMAL 10-30-13 12:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91668 F 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY 91668 F 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION 91668 F 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT 10-14-13 13:26 P LACRIMATION 10-17-13 11:43 1 DRIED RED MATERIAL AROUND NOSE 11-06-13 11:46 1 WET RED MATERIAL AROUND NOSE 11-13-13 11:40 1 DRIED RED MATERIAL AROUND NOSE 91668 F 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION 10-25-13 14:14 1 SALIVATION 10-28-13 12:58 3 WET CLEAR MATERIAL AROUND MOUTH 10-28-13 12:58 3 SALIVATION 10-29-13 12:30 3 WET CLEAR MATERIAL AROUND MOUTH 10-29-13 12:30 3 SALIVATION 10-31-13 11:53 2 WET CLEAR MATERIAL AROUND MOUTH 10-31-13 11:54 2 SALIVATION 11-01-13 11:40 3 WET CLEAR MATERIAL AROUND MOUTH 11-01-13 11:40 3 SALIVATION 11-02-13 11:38 2 WET CLEAR MATERIAL AROUND MOUTH 11-02-13 11:38 1 SALIVATION 11-03-13 11:18 3 WET CLEAR MATERIAL AROUND MOUTH 11-03-13 11:18 3 SALIVATION 11-04-13 12:08 2 WET CLEAR MATERIAL AROUND MOUTH 11-05-13 11:24 2 WET CLEAR MATERIAL AROUND MOUTH 11-05-13 11:25 2 SALIVATION 11-06-13 11:46 2 WET CLEAR MATERIAL AROUND MOUTH 11-06-13 11:46 1 SALIVATION 11-07-13 12:00 3 WET CLEAR MATERIAL AROUND MOUTH 11-07-13 12:00 3 SALIVATION

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 446 of 1107**TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91668 F 10000 PPM ORAL/DENTAL 11-08-13 13:04 1 WET CLEAR MATERIAL AROUND MOUTH 11-08-13 13:04 2 SALIVATION 11-09-13 11:56 1 DRIED RED MATERIAL AROUND MOUTH 11-10-13 13:09 2 SALIVATION 11-11-13 12:45 3 WET CLEAR MATERIAL AROUND MOUTH 11-11-13 12:45 2 SALIVATION 11-12-13 11:33 1 WET CLEAR MATERIAL AROUND MOUTH 11-13-13 11:40 1 DRIED RED MATERIAL AROUND MOUTH 11-14-13 12:58 1 SALIVATION 11-15-13 11:58 1 WET CLEAR MATERIAL AROUND MOUTH 11-16-13 11:43 1 DRIED RED MATERIAL AROUND MOUTH 11-17-13 11:47 2 SALIVATION 11-18-13 12:40 2 SALIVATION 11-18-13 12:40 2 WET CLEAR MATERIAL AROUND MOUTH 91680 F 10000 PPM NORMAL 10-15-13 12:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 12:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 11:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 11:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 13:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 11:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 11:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 11:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 11:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 12:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 11:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91680 F 10000 PPM NORMAL 11-07-13 12:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 13:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 11:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 11:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 13:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 12:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 11:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91680 F 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY 91680 F 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION 91680 F 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT 10-14-13 13:26 P LACRIMATION 10-21-13 12:42 1 WET RED MATERIAL AROUND NOSE 11-01-13 11:43 1 WET RED MATERIAL AROUND NOSE 91680 F 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION 10-17-13 11:46 1 WET CLEAR MATERIAL AROUND MOUTH 10-20-13 11:24 2 SALIVATION 10-28-13 13:00 2 WET CLEAR MATERIAL AROUND MOUTH 10-29-13 12:33 1 WET RED MATERIAL AROUND MOUTH 10-30-13 12:32 1 SALIVATION 11-01-13 11:43 2 WET RED MATERIAL AROUND MOUTH 11-10-13 13:11 1 WET RED MATERIAL AROUND MOUTH 11-11-13 12:47 1 WET CLEAR MATERIAL AROUND MOUTH 11-17-13 11:49 2 WET CLEAR MATERIAL AROUND MOUTH

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PCRDv4.18 01/24/2014**Page 448 of 1107**TABLE A7 (F0 FEMALES - 1 HOUR POST-EXPOSURE - GROUP 5)

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91624 F 10000 PPM NORMAL 10-14-13 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 13:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 13:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 12:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 12:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 13:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 13:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 12:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 12:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 12:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 13:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 13:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 13:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 12:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 12:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 12:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 12:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 12:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 12:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 13:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 12:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 13:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 13:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91624 F 10000 PPM NORMAL 11-12-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 12:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 13:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 12:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 12:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 13:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-19-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91625 F 10000 PPM NORMAL 10-15-13 13:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 12:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 12:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 12:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 13:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 12:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 12:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 13:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 12:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 12:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 13:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91625 F 10000 PPM BODY/INTEGUMENT 10-28-13 13:41 3 WET CLEAR MATERIAL VENTRAL NECK 10-29-13 13:07 3 WET CLEAR MATERIAL VENTRAL NECK 10-29-13 13:08 2 WET CLEAR MATERIAL LEFT FORELIMB 10-29-13 13:08 2 WET CLEAR MATERIAL RIGHT FORELIMB 11-01-13 12:15 3 WET CLEAR MATERIAL VENTRAL NECK 11-01-13 12:15 2 WET CLEAR MATERIAL LEFT FORELIMB 11-01-13 12:15 2 WET CLEAR MATERIAL RIGHT FORELIMB 11-03-13 12:03 2 WET CLEAR MATERIAL VENTRAL NECK

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 450 of 1107**TABLE A7 (F0 FEMALES - 1 HOUR POST-EXPOSURE - GROUP 5)

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91625 F 10000 PPM BODY/INTEGUMENT 11-03-13 12:03 1 WET CLEAR MATERIAL LEFT FORELIMB 11-04-13 12:42 3 WET CLEAR MATERIAL VENTRAL NECK 11-04-13 12:42 2 WET CLEAR MATERIAL LEFT FORELIMB 11-04-13 12:42 2 WET CLEAR MATERIAL RIGHT FORELIMB 11-05-13 12:00 2 WET CLEAR MATERIAL VENTRAL NECK 11-05-13 12:00 2 WET CLEAR MATERIAL RIGHT FORELIMB 11-05-13 12:00 2 WET CLEAR MATERIAL LEFT FORELIMB 11-06-13 12:22 3 WET CLEAR MATERIAL VENTRAL NECK 11-06-13 12:22 2 WET CLEAR MATERIAL LEFT FORELIMB 11-06-13 12:22 2 WET CLEAR MATERIAL RIGHT FORELIMB 11-07-13 12:37 3 WET CLEAR MATERIAL VENTRAL NECK 11-07-13 12:37 3 WET CLEAR MATERIAL LEFT FORELIMB 11-07-13 12:37 3 WET CLEAR MATERIAL RIGHT FORELIMB 11-09-13 12:39 2 WET CLEAR MATERIAL RIGHT FORELIMB 11-09-13 12:40 2 WET CLEAR MATERIAL VENTRAL NECK 11-09-13 12:40 2 WET CLEAR MATERIAL LEFT FORELIMB 11-10-13 13:53 2 WET CLEAR MATERIAL VENTRAL NECK 11-10-13 13:53 1 WET CLEAR MATERIAL LEFT FORELIMB 11-10-13 13:54 1 WET CLEAR MATERIAL RIGHT FORELIMB 11-11-13 13:20 3 WET CLEAR MATERIAL VENTRAL NECK 11-11-13 13:20 3 WET CLEAR MATERIAL LEFT FORELIMB 11-11-13 13:20 3 WET CLEAR MATERIAL RIGHT FORELIMB 11-12-13 12:13 2 WET CLEAR MATERIAL VENTRAL NECK 11-12-13 12:13 2 WET CLEAR MATERIAL LEFT FORELIMB 11-12-13 12:13 2 WET CLEAR MATERIAL RIGHT FORELIMB 11-13-13 12:20 2 WET CLEAR MATERIAL VENTRAL NECK 11-13-13 12:20 2 WET CLEAR MATERIAL LEFT FORELIMB 11-13-13 12:20 2 WET CLEAR MATERIAL RIGHT FORELIMB 11-14-13 13:37 3 WET CLEAR MATERIAL VENTRAL NECK

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 451 of 1107**TABLE A7 (F0 FEMALES - 1 HOUR POST-EXPOSURE - GROUP 5)

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91625 F 10000 PPM BODY/INTEGUMENT 11-14-13 13:37 3 WET CLEAR MATERIAL LEFT FORELIMB 11-14-13 13:37 3 WET CLEAR MATERIAL RIGHT FORELIMB 11-15-13 12:32 2 WET CLEAR MATERIAL VENTRAL NECK 11-15-13 12:32 2 WET CLEAR MATERIAL LEFT FORELIMB 11-15-13 12:32 2 WET CLEAR MATERIAL RIGHT FORELIMB 11-17-13 12:35 1 WET CLEAR MATERIAL RIGHT FORELIMB 11-17-13 12:35 1 WET CLEAR MATERIAL LEFT FORELIMB 11-17-13 12:35 1 WET CLEAR MATERIAL VENTRAL NECK 11-18-13 13:14 3 WET CLEAR MATERIAL VENTRAL NECK 11-18-13 13:14 3 WET CLEAR MATERIAL LEFT FORELIMB 11-18-13 13:14 3 WET CLEAR MATERIAL RIGHT FORELIMB 11-19-13 12:34 3 WET CLEAR MATERIAL VENTRAL NECK 11-19-13 12:34 3 WET CLEAR MATERIAL LEFT FORELIMB 11-19-13 12:34 3 WET CLEAR MATERIAL RIGHT FORELIMB 11-19-13 12:35 3 WET CLEAR MATERIAL VENTRAL ABDOMINAL AREA 91625 F 10000 PPM EYES/EARS/NOSE 10-24-13 14:19 1 WET RED MATERIAL AROUND NOSE 11-07-13 12:37 2 DRIED RED MATERIAL AROUND NOSE 11-09-13 12:39 2 WET RED MATERIAL AROUND NOSE 91625 F 10000 PPM ORAL/DENTAL 10-14-13 14:17 1 WET CLEAR MATERIAL AROUND MOUTH 10-19-13 12:01 1 WET RED MATERIAL AROUND MOUTH 10-20-13 11:56 2 WET RED MATERIAL AROUND MOUTH 10-21-13 13:13 1 DRIED RED MATERIAL AROUND MOUTH 10-23-13 12:21 2 WET CLEAR MATERIAL AROUND MOUTH 10-24-13 14:18 2 WET CLEAR MATERIAL AROUND MOUTH 10-28-13 13:41 3 WET CLEAR MATERIAL AROUND MOUTH 10-29-13 13:08 3 WET CLEAR MATERIAL AROUND MOUTH 11-01-13 12:15 2 WET CLEAR MATERIAL AROUND MOUTH 11-04-13 12:42 1 WET CLEAR MATERIAL AROUND MOUTH 11-06-13 12:22 3 WET CLEAR MATERIAL AROUND MOUTH

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 452 of 1107**TABLE A7 (F0 FEMALES - 1 HOUR POST-EXPOSURE - GROUP 5)

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91625 F 10000 PPM ORAL/DENTAL 11-07-13 12:37 3 WET CLEAR MATERIAL AROUND MOUTH 11-09-13 12:39 2 WET CLEAR MATERIAL AROUND MOUTH 11-11-13 13:20 3 WET CLEAR MATERIAL AROUND MOUTH 11-12-13 12:13 2 WET CLEAR MATERIAL AROUND MOUTH 11-14-13 13:37 2 WET CLEAR MATERIAL AROUND MOUTH 11-15-13 12:32 1 WET CLEAR MATERIAL AROUND MOUTH 11-18-13 13:14 2 WET CLEAR MATERIAL AROUND MOUTH 11-19-13 12:35 3 WET CLEAR MATERIAL AROUND MOUTH 91627 F 10000 PPM NORMAL 10-14-13 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 13:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 13:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 12:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 12:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 13:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 13:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 12:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 13:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 13:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 13:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 12:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 12:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 12:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 12:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 453 of 1107**TABLE A7 (F0 FEMALES - 1 HOUR POST-EXPOSURE - GROUP 5)

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91627 F 10000 PPM NORMAL 11-05-13 12:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 12:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 13:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 12:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 13:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 13:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 12:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 13:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 12:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 12:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 12:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91627 F 10000 PPM ORAL/DENTAL 10-23-13 12:25 1 DRIED RED MATERIAL AROUND MOUTH 91634 F 10000 PPM NORMAL 10-14-13 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 13:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 13:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 12:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 13:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 13:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 12:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 12:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 13:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91634 F 10000 PPM NORMAL 10-30-13 13:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 12:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 12:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 12:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 12:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 12:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 12:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 13:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 12:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 13:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 12:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 13:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 12:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 13:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-19-13 12:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-20-13 13:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91634 F 10000 PPM EYES/EARS/NOSE 10-28-13 13:42 1 DRIED RED MATERIAL AROUND NOSE 91634 F 10000 PPM ORAL/DENTAL 11-10-13 13:55 1 DRIED RED MATERIAL AROUND MOUTH 91635 F 10000 PPM NORMAL 10-14-13 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 13:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 12:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 12:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 12:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 12:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91635 F 10000 PPM NORMAL 10-20-13 11:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 13:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 13:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 12:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 12:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 12:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 13:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 13:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 13:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 12:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 12:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 12:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 12:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 12:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 12:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 12:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 12:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 13:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 12:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 13:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 13:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 12:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 12:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 13:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 12:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91638 F 10000 PPM NORMAL 10-14-13 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 13:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 12:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 12:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 12:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 12:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 11:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 13:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 13:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 12:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 12:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 12:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 13:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 13:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 12:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 12:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 12:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 12:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 12:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 12:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 12:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 12:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 13:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 12:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 13:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 13:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 12:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91638 F 10000 PPM NORMAL 11-13-13 12:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 13:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 12:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 12:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 13:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-19-13 12:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91638 F 10000 PPM EYES/EARS/NOSE 10-28-13 13:42 2 DRIED RED MATERIAL AROUND NOSE 91652 F 10000 PPM NORMAL 10-14-13 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 13:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 13:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 12:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 13:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 13:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 12:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 12:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 13:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 12:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 12:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 12:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 12:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 12:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91652 F 10000 PPM NORMAL 11-06-13 12:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 13:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 12:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 13:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 13:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 12:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 13:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 12:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 12:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 12:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91652 F 10000 PPM EYES/EARS/NOSE 10-28-13 13:42 3 DRIED RED MATERIAL AROUND NOSE 10-29-13 13:09 2 DRIED RED MATERIAL AROUND NOSE 91655 F 10000 PPM NORMAL 10-14-13 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 13:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 12:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 12:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 12:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 12:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 11:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 13:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 13:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 12:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 12:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 12:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 13:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91655 F 10000 PPM NORMAL 10-30-13 13:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 12:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 12:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 12:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 13:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 13:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 13:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 12:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 13:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 12:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91655 F 10000 PPM EYES/EARS/NOSE 10-28-13 13:40 3 DRIED RED MATERIAL AROUND NOSE 91655 F 10000 PPM ORAL/DENTAL 11-16-13 12:39 1 DRIED RED MATERIAL AROUND MOUTH 91658 F 10000 PPM NORMAL 10-15-13 13:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 13:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 12:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 12:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 13:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 13:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 12:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 460 of 1107**TABLE A7 (F0 FEMALES - 1 HOUR POST-EXPOSURE - GROUP 5)

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91658 F 10000 PPM NORMAL 10-25-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 12:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 12:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 13:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 12:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 12:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 12:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 12:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 12:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 12:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 13:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 12:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 13:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 12:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 13:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 12:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 12:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 13:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91658 F 10000 PPM EYES/EARS/NOSE 10-24-13 14:17 1 DRIED RED MATERIAL AROUND NOSE 10-29-13 13:10 2 DRIED RED MATERIAL AROUND NOSE 10-30-13 13:20 1 DRIED RED MATERIAL AROUND NOSE 10-31-13 12:37 1 DRIED RED MATERIAL AROUND NOSE 11-11-13 13:22 3 DRIED RED MATERIAL AROUND NOSE 11-17-13 12:37 1 DRIED RED MATERIAL AROUND NOSE 91658 F 10000 PPM ORAL/DENTAL 10-14-13 14:19 1 WET CLEAR MATERIAL AROUND MOUTH 10-29-13 13:10 2 DRIED RED MATERIAL AROUND MOUTH 10-30-13 13:20 1 DRIED RED MATERIAL AROUND MOUTH

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 461 of 1107**TABLE A7 (F0 FEMALES - 1 HOUR POST-EXPOSURE - GROUP 5)

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91667 F 10000 PPM NORMAL 10-14-13 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 13:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 12:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 12:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 12:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 12:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 11:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 13:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 13:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 12:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 12:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 12:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 13:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 13:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 13:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 12:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 12:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 12:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 13:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 13:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 13:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 462 of 1107**TABLE A7 (F0 FEMALES - 1 HOUR POST-EXPOSURE - GROUP 5)

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91667 F 10000 PPM NORMAL 11-12-13 12:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 13:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 12:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 13:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91668 F 10000 PPM NORMAL 10-14-13 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 13:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 12:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 12:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 12:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 12:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 11:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 13:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 13:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 12:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 12:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 12:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 13:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 13:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 13:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 12:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 12:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 463 of 1107**TABLE A7 (F0 FEMALES - 1 HOUR POST-EXPOSURE - GROUP 5)

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91668 F 10000 PPM NORMAL 11-05-13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 12:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 13:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 13:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 13:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 12:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 13:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 12:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 13:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91680 F 10000 PPM NORMAL 10-14-13 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 13:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 13:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 12:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 12:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 13:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 13:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 12:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 12:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 12:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 13:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 464 of 1107**TABLE A7 (F0 FEMALES - 1 HOUR POST-EXPOSURE - GROUP 5)

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TABLE RANGE: 10-14-13 TO 11-20-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91680 F 10000 PPM NORMAL 10-30-13 13:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 12:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 12:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 12:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 12:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 12:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 12:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 13:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 12:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 13:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 13:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 12:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 13:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 12:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 12:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 12:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91680 F 10000 PPM EYES/EARS/NOSE 10-28-13 13:43 1 DRIED RED MATERIAL AROUND NOSE

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PCRDv4.18 01/20/2014**Page 465 of 1107**TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91629 F 0 PPM NORMAL 10-14-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91629 F 0 PPM NORMAL 11-12-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-19-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-20-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91630 F 0 PPM NORMAL 10-14-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91630 F 0 PPM NORMAL 11-04-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-19-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-20-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91630 F 0 PPM EYES/EARS/NOSE 10-28-13 16:55 1 DRIED RED MATERIAL AROUND NOSE 91633 F 0 PPM NORMAL 10-14-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91633 F 0 PPM NORMAL 10-25-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91637 F 0 PPM NORMAL 10-14-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91637 F 0 PPM NORMAL 10-18-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91637 F 0 PPM NORMAL 11-16-13 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91639 F 0 PPM NORMAL 10-14-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91639 F 0 PPM NORMAL 11-11-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-19-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91639 F 0 PPM EYES/EARS/NOSE 10-28-13 16:55 1 DRIED RED MATERIAL AROUND NOSE 91644 F 0 PPM NORMAL 10-14-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91644 F 0 PPM NORMAL 11-02-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91645 F 0 PPM NORMAL 10-14-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91645 F 0 PPM NORMAL 10-26-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-19-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-20-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91648 F 0 PPM NORMAL 10-14-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91648 F 0 PPM NORMAL 10-17-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91648 F 0 PPM NORMAL 11-15-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91653 F 0 PPM NORMAL 10-14-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91653 F 0 PPM NORMAL 11-09-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-19-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91660 F 0 PPM NORMAL 10-14-13 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91660 F 0 PPM NORMAL 11-01-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-19-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91670 F 0 PPM NORMAL 10-14-13 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91670 F 0 PPM NORMAL 10-25-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-19-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-20-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91670 F 0 PPM EYES/EARS/NOSE 10-18-13 15:09 1 DRIED RED MATERIAL AROUND NOSE 91672 F 0 PPM NORMAL 10-14-13 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91672 F 0 PPM NORMAL 10-15-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91672 F 0 PPM NORMAL 11-13-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-19-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-20-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91632 F 50 PPM NORMAL 10-14-13 17:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91632 F 50 PPM NORMAL 11-05-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-19-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-20-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-21-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91632 F 50 PPM EYES/EARS/NOSE 11-02-13 14:46 1 DRIED RED MATERIAL AROUND NOSE 91640 F 50 PPM NORMAL 10-14-13 17:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91640 F 50 PPM NORMAL 10-29-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91640 F 50 PPM EYES/EARS/NOSE 10-16-13 15:18 1 DRIED RED MATERIAL AROUND NOSE 10-18-13 15:10 1 DRIED RED MATERIAL AROUND NOSE 10-23-13 15:09 1 DRIED RED MATERIAL AROUND NOSE 10-28-13 16:57 1 DRIED RED MATERIAL AROUND NOSE 11-02-13 14:46 1 DRIED RED MATERIAL AROUND NOSE 11-11-13 16:00 1 DRIED RED MATERIAL AROUND NOSE 11-12-13 15:06 1 DRIED RED MATERIAL AROUND NOSE 11-13-13 15:08 1 DRIED RED MATERIAL AROUND NOSE 11-15-13 15:28 1 DRIED RED MATERIAL AROUND NOSE 11-16-13 14:33 1 DRIED RED MATERIAL AROUND NOSE 11-17-13 15:16 1 DRIED RED MATERIAL AROUND NOSE 11-18-13 15:40 2 DRIED RED MATERIAL AROUND NOSE 11-19-13 15:16 1 DRIED RED MATERIAL AROUND NOSE 11-20-13 15:31 1 DRIED RED MATERIAL AROUND NOSE 11-21-13 15:10 1 DRIED RED MATERIAL AROUND NOSE 91642 F 50 PPM NORMAL 10-14-13 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91642 F 50 PPM NORMAL 10-15-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91642 F 50 PPM NORMAL 11-14-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91642 F 50 PPM EYES/EARS/NOSE 10-28-13 16:57 2 DRIED RED MATERIAL AROUND NOSE 11-18-13 15:41 1 DRIED RED MATERIAL AROUND NOSE 91647 F 50 PPM NORMAL 10-14-13 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91647 F 50 PPM NORMAL 11-06-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-19-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-20-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91651 F 50 PPM NORMAL 10-14-13 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91651 F 50 PPM NORMAL 10-28-13 16:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91659 F 50 PPM NORMAL 10-14-13 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91659 F 50 PPM NORMAL 10-22-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91659 F 50 PPM EYES/EARS/NOSE 10-18-13 15:11 1 DRIED RED MATERIAL AROUND NOSE

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91661 F 50 PPM NORMAL 10-14-13 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91661 F 50 PPM NORMAL 11-13-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91661 F 50 PPM EYES/EARS/NOSE 10-28-13 16:59 2 DRIED RED MATERIAL AROUND NOSE 91663 F 50 PPM NORMAL 10-14-13 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91663 F 50 PPM NORMAL 11-07-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-19-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91663 F 50 PPM EYES/EARS/NOSE 10-28-13 16:59 1 DRIED RED MATERIAL AROUND NOSE 11-17-13 15:16 1 DRIED RED MATERIAL AROUND NOSE 91669 F 50 PPM NORMAL 10-14-13 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91669 F 50 PPM NORMAL 10-29-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91673 F 50 PPM NORMAL 10-14-13 17:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91673 F 50 PPM NORMAL 10-25-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-19-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-20-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91673 F 50 PPM EYES/EARS/NOSE 10-15-13 15:42 1 DRIED RED MATERIAL AROUND NOSE 10-23-13 15:10 1 DRIED RED MATERIAL AROUND NOSE 10-28-13 16:59 2 DRIED RED MATERIAL AROUND NOSE

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91683 F 50 PPM NORMAL 10-14-13 17:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91683 F 50 PPM NORMAL 11-14-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-19-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-20-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-21-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91683 F 50 PPM EYES/EARS/NOSE 10-28-13 17:00 1 DRIED RED MATERIAL AROUND NOSE 11-02-13 14:47 1 DRIED RED MATERIAL AROUND NOSE 91685 F 50 PPM NORMAL 10-14-13 17:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91685 F 50 PPM NORMAL 11-02-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91685 F 50 PPM EYES/EARS/NOSE 11-16-13 14:35 1 DRIED RED MATERIAL AROUND NOSE 91620 F 100 PPM NORMAL 10-15-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91620 F 100 PPM NORMAL 10-28-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-19-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91620 F 100 PPM EYES/EARS/NOSE 10-14-13 17:11 1 DRIED RED MATERIAL AROUND NOSE 91628 F 100 PPM NORMAL 10-14-13 17:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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----------------------------------------------------------------------------------------------------------------------------------- 91628 F 100 PPM NORMAL 10-19-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91628 F 100 PPM NORMAL 11-18-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91628 F 100 PPM EYES/EARS/NOSE 10-28-13 17:01 1 DRIED RED MATERIAL AROUND NOSE 91631 F 100 PPM NORMAL 10-14-13 17:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91631 F 100 PPM NORMAL 11-14-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91631 F 100 PPM EYES/EARS/NOSE 10-19-13 15:07 1 DRIED RED MATERIAL AROUND NOSE 10-21-13 15:57 1 DRIED RED MATERIAL AROUND NOSE 10-22-13 15:21 1 DRIED RED MATERIAL AROUND NOSE 10-23-13 15:15 1 DRIED RED MATERIAL AROUND NOSE 91636 F 100 PPM NORMAL 10-14-13 17:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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----------------------------------------------------------------------------------------------------------------------------------- 91636 F 100 PPM NORMAL 11-05-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-19-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91636 F 100 PPM EYES/EARS/NOSE 10-23-13 15:15 2 DRIED RED MATERIAL AROUND NOSE 11-02-13 14:48 1 DRIED RED MATERIAL AROUND NOSE 91649 F 100 PPM NORMAL 10-14-13 17:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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----------------------------------------------------------------------------------------------------------------------------------- 91649 F 100 PPM NORMAL 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91649 F 100 PPM EYES/EARS/NOSE 11-02-13 14:48 1 DRIED RED MATERIAL AROUND NOSE 91650 F 100 PPM NORMAL 10-14-13 17:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91650 F 100 PPM NORMAL 10-21-13 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91650 F 100 PPM EYES/EARS/NOSE 10-20-13 14:54 1 DRIED RED MATERIAL AROUND NOSE 11-16-13 14:36 1 DRIED RED MATERIAL AROUND NOSE

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91656 F 100 PPM NORMAL 10-14-13 17:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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----------------------------------------------------------------------------------------------------------------------------------- 91656 F 100 PPM NORMAL 11-13-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-19-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-20-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-21-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-22-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91656 F 100 PPM EYES/EARS/NOSE 10-23-13 15:16 1 DRIED RED MATERIAL AROUND NOSE 11-16-13 14:36 1 DRIED RED MATERIAL AROUND NOSE 91671 F 100 PPM NORMAL 10-14-13 17:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91671 F 100 PPM NORMAL 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-19-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-20-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-21-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91675 F 100 PPM NORMAL 10-14-13 17:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91675 F 100 PPM NORMAL 10-24-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91675 F 100 PPM EYES/EARS/NOSE 10-19-13 15:08 1 DRIED RED MATERIAL AROUND NOSE 10-23-13 15:16 1 DRIED RED MATERIAL AROUND NOSE 10-28-13 17:02 2 DRIED RED MATERIAL AROUND NOSE 10-29-13 15:47 1 DRIED RED MATERIAL AROUND NOSE 11-02-13 14:48 1 DRIED RED MATERIAL AROUND NOSE 11-11-13 16:03 1 DRIED RED MATERIAL AROUND NOSE 91677 F 100 PPM NORMAL 10-14-13 17:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91677 F 100 PPM NORMAL 10-16-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91677 F 100 PPM NORMAL 11-16-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91677 F 100 PPM EYES/EARS/NOSE 10-22-13 15:23 1 DRIED RED MATERIAL AROUND NOSE 10-23-13 15:16 1 DRIED RED MATERIAL AROUND NOSE 91679 F 100 PPM NORMAL 10-14-13 17:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91679 F 100 PPM NORMAL 11-07-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91679 F 100 PPM EYES/EARS/NOSE 11-12-13 15:09 1 DRIED RED MATERIAL AROUND NOSE 91684 F 100 PPM NORMAL 10-14-13 17:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91684 F 100 PPM NORMAL 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91684 F 100 PPM EYES/EARS/NOSE 11-16-13 14:37 1 DRIED RED MATERIAL AROUND NOSE 91622 F 175 PPM NORMAL 10-14-13 17:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91622 F 175 PPM NORMAL 10-29-13 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91622 F 175 PPM EYES/EARS/NOSE 10-20-13 14:55 1 DRIED RED MATERIAL AROUND NOSE 10-21-13 15:59 1 DRIED RED MATERIAL AROUND NOSE 10-23-13 15:17 2 DRIED RED MATERIAL AROUND NOSE 10-28-13 17:04 2 DRIED RED MATERIAL AROUND NOSE 11-03-13 14:50 1 DRIED RED MATERIAL AROUND NOSE 11-12-13 15:09 1 DRIED RED MATERIAL AROUND NOSE 11-16-13 14:37 1 DRIED RED MATERIAL AROUND NOSE 91623 F 175 PPM NORMAL 10-14-13 17:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91623 F 175 PPM NORMAL 10-19-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-19-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91623 F 175 PPM NORMAL 11-20-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-21-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-22-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-23-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-24-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-25-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-27-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-29-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-30-13 14:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 12-01-13 14:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 12-02-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 12-03-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 12-04-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91623 F 175 PPM EYES/EARS/NOSE 10-23-13 15:17 1 DRIED RED MATERIAL AROUND NOSE 11-11-13 16:04 1 DRIED RED MATERIAL AROUND NOSE 11-12-13 15:10 1 DRIED RED MATERIAL AROUND NOSE 11-26-13 15:02 1 DRIED RED MATERIAL AROUND NOSE 11-28-13 14:32 1 DRIED RED MATERIAL AROUND NOSE 91626 F 175 PPM NORMAL 10-14-13 17:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91626 F 175 PPM NORMAL 10-25-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-20-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91626 F 175 PPM EYES/EARS/NOSE 10-28-13 17:04 1 DRIED RED MATERIAL AROUND NOSE 10-29-13 15:48 1 DRIED RED MATERIAL AROUND NOSE 11-08-13 15:02 1 DRIED RED MATERIAL AROUND NOSE 11-10-13 17:04 1 DRIED RED MATERIAL AROUND NOSE 11-11-13 16:04 1 DRIED RED MATERIAL AROUND NOSE 11-13-13 15:13 1 DRIED RED MATERIAL AROUND NOSE 11-19-13 15:18 1 DRIED RED MATERIAL AROUND NOSE 91643 F 175 PPM NORMAL 10-14-13 17:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91643 F 175 PPM NORMAL 10-16-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91643 F 175 PPM NORMAL 11-15-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-19-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-20-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-21-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-22-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-23-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91643 F 175 PPM EYES/EARS/NOSE 10-22-13 15:24 1 DRIED RED MATERIAL AROUND NOSE 91654 F 175 PPM NORMAL 10-14-13 17:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91654 F 175 PPM NORMAL 11-05-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-19-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-21-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-22-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91654 F 175 PPM EYES/EARS/NOSE 10-24-13 15:04 1 DRIED RED MATERIAL AROUND NOSE 10-29-13 15:49 2 WET RED MATERIAL AROUND NOSE 10-29-13 15:49 1 DRIED RED MATERIAL AROUND NOSE 11-03-13 14:52 2 DRIED RED MATERIAL AROUND NOSE 11-11-13 16:05 1 DRIED RED MATERIAL AROUND NOSE 11-15-13 15:32 1 DRIED RED MATERIAL AROUND NOSE 11-16-13 14:38 1 DRIED RED MATERIAL AROUND NOSE 11-20-13 15:33 1 DRIED RED MATERIAL AROUND NOSE 91657 F 175 PPM NORMAL 10-14-13 17:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91657 F 175 PPM NORMAL 10-21-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-19-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91657 F 175 PPM NORMAL 11-20-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-21-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-22-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-23-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-24-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-25-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-26-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-27-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-28-13 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91657 F 175 PPM EYES/EARS/NOSE 11-02-13 14:50 1 DRIED RED MATERIAL AROUND NOSE 91662 F 175 PPM NORMAL 10-14-13 17:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91662 F 175 PPM NORMAL 11-02-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-19-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91662 F 175 PPM EYES/EARS/NOSE 11-11-13 16:05 1 DRIED RED MATERIAL AROUND NOSE 11-12-13 15:10 1 DRIED RED MATERIAL AROUND NOSE 11-15-13 15:32 1 DRIED RED MATERIAL AROUND NOSE 91666 F 175 PPM NORMAL 10-14-13 17:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91666 F 175 PPM NORMAL 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91666 F 175 PPM EYES/EARS/NOSE 11-02-13 14:51 1 DRIED RED MATERIAL AROUND NOSE 91676 F 175 PPM NORMAL 10-14-13 17:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91676 F 175 PPM NORMAL 10-19-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91676 F 175 PPM NORMAL 11-18-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91676 F 175 PPM EYES/EARS/NOSE 10-28-13 17:06 1 DRIED RED MATERIAL AROUND NOSE 91678 F 175 PPM NORMAL 10-14-13 17:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91678 F 175 PPM NORMAL 11-10-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91678 F 175 PPM EYES/EARS/NOSE 11-16-13 14:39 1 DRIED RED MATERIAL AROUND NOSE 91681 F 175 PPM NORMAL 10-14-13 17:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91681 F 175 PPM NORMAL 11-06-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-22-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-23-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-24-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-25-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91681 F 175 PPM EYES/EARS/NOSE 11-02-13 14:51 2 DRIED RED MATERIAL AROUND NOSE 11-03-13 14:53 1 DRIED RED MATERIAL AROUND NOSE 11-08-13 15:03 1 DRIED RED MATERIAL AROUND NOSE 11-13-13 15:14 1 DRIED RED MATERIAL AROUND NOSE 11-15-13 15:32 1 DRIED RED MATERIAL AROUND NOSE 11-18-13 15:45 1 DRIED RED MATERIAL AROUND NOSE 11-19-13 15:18 2 DRIED RED MATERIAL AROUND NOSE 11-20-13 15:33 1 DRIED RED MATERIAL AROUND NOSE 11-21-13 15:11 1 DRIED RED MATERIAL AROUND NOSE 11-26-13 15:02 1 DRIED RED MATERIAL AROUND NOSE 91682 F 175 PPM NORMAL 10-14-13 17:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91682 F 175 PPM NORMAL 10-20-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-19-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91682 F 175 PPM EYES/EARS/NOSE 10-22-13 15:26 1 DRIED RED MATERIAL AROUND NOSE

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91682 F 175 PPM EYES/EARS/NOSE 10-28-13 17:07 1 DRIED RED MATERIAL AROUND NOSE 11-02-13 14:51 1 DRIED RED MATERIAL AROUND NOSE 91624 F 10000 PPM NORMAL 10-14-13 17:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91624 F 10000 PPM NORMAL 11-10-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-19-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91625 F 10000 PPM NORMAL 10-14-13 17:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91625 F 10000 PPM NORMAL 11-03-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-19-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91625 F 10000 PPM ORAL/DENTAL 10-29-13 15:51 1 DRIED RED MATERIAL AROUND MOUTH 91627 F 10000 PPM NORMAL 10-14-13 17:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91627 F 10000 PPM NORMAL 10-26-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91627 F 10000 PPM EYES/EARS/NOSE 10-21-13 16:01 1 DRIED RED MATERIAL AROUND NOSE 91634 F 10000 PPM NORMAL 10-14-13 17:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91634 F 10000 PPM NORMAL 10-19-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91634 F 10000 PPM NORMAL 11-18-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-19-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-20-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91634 F 10000 PPM EYES/EARS/NOSE 11-16-13 14:41 1 DRIED RED MATERIAL AROUND NOSE 91635 F 10000 PPM NORMAL 10-14-13 17:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91635 F 10000 PPM NORMAL 11-08-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91638 F 10000 PPM NORMAL 10-14-13 17:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91638 F 10000 PPM NORMAL 11-04-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-19-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91638 F 10000 PPM EYES/EARS/NOSE 10-23-13 15:23 1 DRIED RED MATERIAL AROUND NOSE 10-29-13 15:52 1 DRIED RED MATERIAL AROUND NOSE 91652 F 10000 PPM NORMAL 10-14-13 17:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91652 F 10000 PPM NORMAL 10-25-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91652 F 10000 PPM EYES/EARS/NOSE 10-29-13 15:52 1 DRIED RED MATERIAL AROUND NOSE 91655 F 10000 PPM NORMAL 10-14-13 17:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91655 F 10000 PPM NORMAL 10-19-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91655 F 10000 PPM NORMAL 11-17-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91658 F 10000 PPM NORMAL 10-15-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91658 F 10000 PPM NORMAL 11-14-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91658 F 10000 PPM EYES/EARS/NOSE 10-14-13 17:17 1 DRIED RED MATERIAL AROUND NOSE 10-29-13 15:53 1 DRIED RED MATERIAL AROUND NOSE 11-01-13 15:09 1 DRIED RED MATERIAL AROUND NOSE 11-17-13 15:22 1 DRIED RED MATERIAL AROUND NOSE 91658 F 10000 PPM ORAL/DENTAL 10-29-13 15:53 1 DRIED RED MATERIAL AROUND MOUTH 91667 F 10000 PPM NORMAL 10-14-13 17:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 539 of 1107**TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91667 F 10000 PPM NORMAL 11-03-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91667 F 10000 PPM EYES/EARS/NOSE 11-17-13 15:22 1 DRIED RED MATERIAL AROUND NOSE 91668 F 10000 PPM NORMAL 10-14-13 17:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-20-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 540 of 1107**TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91668 F 10000 PPM NORMAL 10-27-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-18-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91680 F 10000 PPM NORMAL 10-14-13 17:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-15-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-16-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-17-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-18-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-19-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT**Page 541 of 1107**TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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TABLE RANGE: 10-14-13 TO 12-04-13

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91680 F 10000 PPM NORMAL 10-20-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-21-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-22-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-23-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-24-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-25-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-26-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-27-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-28-13 16:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-29-13 15:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-30-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 10-31-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-01-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-02-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-03-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-04-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-05-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-06-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-07-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-08-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-09-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-10-13 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-11-13 16:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-12-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-13-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-14-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-15-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-16-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 11-17-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PCRDv4.18 01/20/2014 R:01/21/2014**Page 542 of 1107**TABLE A9 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS [G]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 0 7 13 21 28

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 1: 0 PPM

------------------------------------------- 91555 384. 399. 422. 434. 460. 91560 364. 386. 407. 432. 458. 91562 371. 384. 392. 408. 430. 91563 353. 370. 388. 396. 414. 91564 368. 376. 397. 403. 416. 91567 347. 362. 371. 383. 411. 91579 386. 395. 419. 447. 469. 91586 364. 373. 401. 437. 458. 91591 384. 398. 412. 430. 456. 91592 403. 425. 455. 477. 499. 91609 359. 375. 400. 418. 440. 91615 366. 397. 419. 429. 469.

MEAN 371. 387. 407. 424. 448. S.D. 16.0 17.3 21.2 25.1 26.8 S.E. 4.6 5.0 6.1 7.3 7.7 N 12 12 12 12 12**Page 543 of 1107**TABLE A9 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS [G]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 0 7 13 21 28

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 2: 50 PPM

------------------------------------------- 91556 367. 396. 415. 436. 452. 91559 375. 379. 393. 410. 428. 91561 345. 379. 413. 437. 455. 91566 359. 377. 395. 410. 428. 91576 355. 367. 390. 398. 413. 91582 413. 427. 454. 477. 513. 91585 382. 416. 437. 460. 484. 91589 345. 356. 383. 398. 416. 91593 376. 395. 421. 436. 456. 91594 373. 391. 418. 435. 452. 91595 390. 416. 440. 462. 485. 91602 388. 415. 442. 475. 495.

MEAN 372. 393. 417. 436. 456. S.D. 19.9 22.2 23.2 28.2 32.1 S.E. 5.8 6.4 6.7 8.1 9.3 N 12 12 12 12 12**Page 544 of 1107**TABLE A9 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS [G]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 0 7 13 21 28

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 3: 100 PPM

------------------------------------------- 91569 368. 369. 389. 409. 430. 91573 363. 378. 380. 391. 414. 91577 354. 367. 387. 397. 413. 91581 410. 395. 392. 425. 439. 91583 377. 383. 391. 406. 407. 91588 391. 403. 420. 433. 456. 91590 387. 397. 421. 434. 448. 91598 355. 380. 391. 400. 410. 91599 350. 368. 390. 399. 416. 91608 367. 388. 411. 427. 447. 91611 386. 408. 422. 433. 441. 91616 379. 391. 419. 424. 452.

MEAN 374. 386. 401. 415. 431. S.D. 17.7 13.7 16.0 16.0 18.1 S.E. 5.1 4.0 4.6 4.6 5.2 N 12 12 12 12 12**Page 545 of 1107**TABLE A9 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS [G]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 0 7 13 21 28

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 4: 175 PPM

------------------------------------------- 91565 345. 351. 372. 395. 405. 91568 400. 427. 437. 441. 439. 91570 370. 387. 415. 419. 425. 91572 377. 374. 393. 410. 427. 91580 348. 367. 389. 404. 412. 91584 367. 377. 404. 417. 427. 91587 358. 396. 426. 450. 472. 91597 367. 384. 397. 419. 437. 91601 353. 368. 391. 410. 430. 91607 385. 384. 405. 437. 468. 91613 385. 380. 409. 439. 451. 91614 381. 408. 436. 436. 466.

MEAN 370. 384. 406. 423. 438. S.D. 16.5 20.0 19.8 17.1 21.9 S.E. 4.8 5.8 5.7 4.9 6.3 N 12 12 12 12 12**Page 546 of 1107**TABLE A9 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS [G]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 0 7 13 21 28

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 5: 10000 PPM

------------------------------------------- 91554 355. 369. 380. 398. 413. 91557 385. 397. 411. 440. 459. 91558 386. 382. 405. 409. 423. 91571 338. 354. 355. 371. 370. 91575 383. 391. 417. 438. 443. 91600 400. 409. 424. 438. 447. 91603 378. 375. 388. 402. 415. 91604 382. 390. 393. 408. 432. 91605 348. 353. 364. 388. 399. 91612 360. 348. 358. 379. 394. 91618 368. 370. 373. 388. 406. 91619 356. 364. 378. 391. 410.

MEAN 370. 375. 387. 404. 418. S.D. 18.6 19.1 23.3 23.6 24.9 S.E. 5.4 5.5 6.7 6.8 7.2 N 12 12 12 12 12 PJTBWv4.27 11/25/2013**Page 547 of 1107**TABLE A10 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES [G]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 0- 7 7- 13 13- 21 21- 28 0- 13 0- 28

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 1: 0 PPM

------------------------------------------- 91555 15. 23. 12. 27. 38. 76. 91560 22. 21. 25. 27. 43. 95. 91562 13. 9. 16. 23. 21. 59. 91563 17. 17. 8. 18. 35. 61. 91564 7. 21. 6. 13. 29. 47. 91567 15. 10. 12. 28. 24. 64. 91579 9. 24. 28. 23. 33. 83. 91586 9. 27. 36. 22. 36. 94. 91591 14. 14. 17. 26. 28. 72. 91592 22. 30. 22. 22. 53. 97. 91609 17. 25. 18. 22. 42. 82. 91615 32. 21. 11. 39. 53. 103.

MEAN 16. 20. 18. 24. 36. 78. S.D. 6.8 6.7 8.9 6.4 10.1 17.5 S.E. 2.0 1.9 2.6 1.8 2.9 5.0 N 12 12 12 12 12 12**Page 548 of 1107**TABLE A10 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES [G]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 0- 7 7- 13 13- 21 21- 28 0- 13 0- 28

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 2: 50 PPM

------------------------------------------- 91556 29. 19. 21. 16. 48. 86. 91559 4. 14. 16. 18. 18. 52. 91561 34. 34. 24. 18. 69. 111. 91566 17. 18. 15. 19. 36. 69. 91576 12. 23. 9. 15. 35. 58. 91582 14. 27. 23. 36. 41. 99. 91585 34. 21. 23. 24. 55. 102. 91589 11. 27. 15. 18. 38. 71. 91593 19. 26. 16. 19. 44. 79. 91594 18. 27. 18. 16. 45. 79. 91595 26. 24. 22. 23. 50. 95. 91602 28. 27. 33. 19. 55. 107.

MEAN 20. 24. 20. 20. 44. 84. S.D. 9.7 5.3 6.2 5.5 12.8 19.1 S.E. 2.8 1.5 1.8 1.6 3.7 5.5 N 12 12 12 12 12 12**Page 549 of 1107**TABLE A10 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES [G]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 0- 7 7- 13 13- 21 21- 28 0- 13 0- 28

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 3: 100 PPM

------------------------------------------- 91569 1. 20. 20. 21. 21. 62. 91573 15. 2. 11. 23. 17. 51. 91577 13. 19. 11. 16. 33. 59. 91581 -15. -2. 32. 14. -18. 29. 91583 6. 8. 15. 1. 14. 30. 91588 12. 17. 13. 23. 28. 65. 91590 11. 24. 13. 13. 35. 61. 91598 25. 11. 9. 10. 36. 56. 91599 18. 22. 9. 17. 39. 66. 91608 20. 23. 16. 20. 44. 80. 91611 22. 14. 11. 8. 37. 55. 91616 12. 28. 5. 28. 40. 73.

MEAN 12. 16. 14. 16. 27. 57. S.D. 10.8 9.2 6.9 7.6 16.9 15.1 S.E. 3.1 2.7 2.0 2.2 4.9 4.3 N 12 12 12 12 12 12**Page 550 of 1107**TABLE A10 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES [G]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 0- 7 7- 13 13- 21 21- 28 0- 13 0- 28

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 4: 175 PPM

------------------------------------------- 91565 6. 21. 23. 11. 26. 60. 91568 28. 10. 4. -2. 38. 39. 91570 17. 27. 5. 5. 45. 55. 91572 -3. 18. 18. 17. 15. 50. 91580 19. 21. 16. 7. 40. 63. 91584 10. 27. 13. 10. 37. 60. 91587 38. 31. 24. 22. 69. 114. 91597 17. 14. 21. 18. 30. 70. 91601 15. 24. 19. 20. 38. 77. 91607 0. 20. 32. 32. 20. 84. 91613 -5. 29. 30. 12. 24. 66. 91614 27. 28. 0. 30. 55. 85.

MEAN 14. 22. 17. 15. 36. 68. S.D. 13.2 6.3 10.1 9.9 15.1 19.7 S.E. 3.8 1.8 2.9 2.9 4.3 5.7 N 12 12 12 12 12 12**Page 551 of 1107**TABLE A10 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES [G]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 0- 7 7- 13 13- 21 21- 28 0- 13 0- 28

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 5: 10000 PPM

------------------------------------------- 91554 14. 11. 18. 15. 25. 58. 91557 12. 14. 29. 18. 26. 74. 91558 -4. 23. 4. 15. 19. 37. 91571 16. 2. 16. -1. 17. 33. 91575 8. 26. 21. 5. 34. 60. 91600 9. 16. 14. 9. 24. 48. 91603 -3. 12. 15. 13. 9. 37. 91604 8. 2. 16. 23. 10. 50. 91605 5. 11. 24. 11. 16. 51. 91612 -12. 10. 21. 15. -2. 34. 91618 1. 3. 15. 17. 5. 37. 91619 8. 13. 13. 19. 22. 54.

MEAN 5. 12. 17. 13. 17. 48. S.D. 8.0 7.5 6.4 6.6 10.1 12.4 S.E. 2.3 2.2 1.8 1.9 2.9 3.6 N 12 12 12 12 12 12 PJTBWv4.27 11/25/2013**Page 552 of 1107**TABLE A11 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS [G]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 0 7 13 21 27 35 42 49

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 1: 0 PPM

------------------------------------------- 91629 241. 240. 238. NA NA NA NA 91630 246. 262. 261. NA NA NA NA 91633 273. 283. 299. NA NA NA 91637 237. 254. 268. NA NA NA 91639 264. 276. 288. NA NA NA NA 91644 240. 245. 266. NA NA NA 91645 265. 277. 284. NA NA NA NA 91648 258. 264. 281. NA NA NA 91653 250. 253. 278. NA NA NA NA 91660 239. 281. 285. NA NA NA NA 91670 253. 269. 274. NA NA NA NA 91672 255. 282. 289. NA NA NA NA

MEAN 252. 265. 276. NA NA NA NA S.D. 11.7 14.7 16.1 S.E. 3.4 4.2 4.7 N 12 12 12

NA = NOT APPLICABLE**Page 553 of 1107**TABLE A11 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS [G]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 0 7 13 21 27 35 42 49

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 2: 50 PPM

------------------------------------------- 91632 245. 272. 279. NA NA NA NA 91640 264. 280. 286. NA NA NA NA 91642 253. 271. 288. NA NA NA 91647 228. 244. 241. NA NA NA NA 91651 254. 275. 284. NA NA NA NA 91659 263. 277. 304. NA NA NA 91661 241. 254. 271. NA NA NA 91663 228. 238. 282. NA NA NA NA 91669 245. 264. 286. NA NA NA 91673 260. 270. 273. NA NA NA NA 91683 235. 252. 256. NA NA NA NA 91685 236. 249. 254. NA NA NA

MEAN 246. 262. 275. NA NA NA NA S.D. 12.8 14.3 17.6 S.E. 3.7 4.1 5.1 N 12 12 12

NA = NOT APPLICABLE**Page 554 of 1107**TABLE A11 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS [G]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 0 7 13 21 27 35 42 49

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 3: 100 PPM

------------------------------------------- 91620 248. 266. 293. NA NA NA NA 91628 232. 237. 250. NA NA NA 91631 256. 276. 297. NA NA NA 91636 230. 235. 261. NA NA NA NA 91649 220. 240. 248. NA NA NA 91650 246. 269. 277. NA NA NA 91656 259. 272. 301. NA NA NA NA 91671 235. 267. 280. NA NA NA NA 91675 261. 280. 288. NA NA NA 91677 224. 255. 274. NA NA NA NA 91679 264. 283. 295. NA NA NA 91684 240. 258. 269. NA NA NA

MEAN 243. 261. 278. NA NA NA NA S.D. 15.1 16.6 18.1 S.E. 4.4 4.8 5.2 N 12 12 12

NA = NOT APPLICABLE**Page 555 of 1107**TABLE A11 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS [G]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 0 7 13 21 27 35 42 49

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 4: 175 PPM

------------------------------------------- 91622 250. 246. 257. NA NA NA 91623 255. 261. 274. 297. 313. 318. 313. 320. 91626 263. 272. 293. NA NA NA NA 91643 261. 271. 289. NA NA NA NA 91654 238. 246. 270. NA NA NA NA 91657 268. 275. 295. 325. NA NA NA NA 91662 255. 267. 293. NA NA NA NA 91666 226. 242. 256. NA NA NA 91676 221. 243. 259. NA NA NA NA 91678 263. 299. 317. NA NA NA 91681 251. 265. 286. 300. NA NA NA NA 91682 269. 283. 299. NA NA NA NA

MEAN 252. 264. 282. 307. 313. 318. 313. 320. S.D. 15.8 17.6 19.0 15.2 0.0 0.0 0.0 0.0 S.E. 4.6 5.1 5.5 8.8 0.0 0.0 0.0 0.0 N 12 12 12 3 1 1 1 1

NA = NOT APPLICABLE**Page 556 of 1107**TABLE A11 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS [G]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 0 7 13 21 27 35 42 49

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 5: 10000 PPM

------------------------------------------- 91624 228. 248. 269. NA NA NA NA 91625 239. 244. 257. NA NA NA NA 91627 251. 251. 256. NA NA NA 91634 238. 249. 262. NA NA NA NA 91635 268. 275. 283. NA NA NA 91638 242. 260. 270. NA NA NA NA 91652 241. 250. 265. NA NA NA 91655 239. 251. 265. NA NA NA 91658 239. 266. 273. NA NA NA 91667 272. 277. 286. NA NA NA 91668 249. 255. 271. NA NA NA 91680 243. 261. 266. NA NA NA

MEAN 246. 257. 269. NA NA NA NA S.D. 12.8 10.6 9.1 S.E. 3.7 3.1 2.6 N 12 12 12

NA = NOT APPLICABLE PJTBWv4.27 01/07/2014**Page 557 of 1107**TABLE A12 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES [G]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 0- 7 7- 13 13- 21 21- 27 27- 35 35- 42 42- 49 0- 13

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 1: 0 PPM

------------------------------------------- 91629 -1. -2. NA NA NA NA -3. 91630 16. -1. NA NA NA NA 16. 91633 10. 17. NA NA NA 26. 91637 17. 14. NA NA NA 31. 91639 12. 12. NA NA NA NA 24. 91644 6. 20. NA NA NA 26. 91645 12. 7. NA NA NA NA 19. 91648 6. 16. NA NA NA 22. 91653 4. 25. NA NA NA NA 29. 91660 42. 4. NA NA NA NA 46. 91670 15. 5. NA NA NA NA 21. 91672 27. 8. NA NA NA NA 34.

MEAN 14. 10. NA NA NA NA 24. S.D. 11.4 8.3 11.7 S.E. 3.3 2.4 3.4 N 12 12 12

NA = NOT APPLICABLE**Page 558 of 1107**TABLE A12 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES [G]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 0- 7 7- 13 13- 21 21- 27 27- 35 35- 42 42- 49 0- 13

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 2: 50 PPM

------------------------------------------- 91632 27. 7. NA NA NA NA 34. 91640 16. 6. NA NA NA NA 22. 91642 18. 16. NA NA NA 34. 91647 16. -3. NA NA NA NA 13. 91651 22. 9. NA NA NA NA 31. 91659 14. 27. NA NA NA 42. 91661 13. 17. NA NA NA 30. 91663 9. 44. NA NA NA NA 54. 91669 19. 22. NA NA NA 41. 91673 10. 3. NA NA NA NA 13. 91683 18. 3. NA NA NA NA 21. 91685 12. 6. NA NA NA 18.

MEAN 16. 13. NA NA NA NA 29. S.D. 5.1 13.1 12.5 S.E. 1.5 3.8 3.6 N 12 12 12

NA = NOT APPLICABLE**Page 559 of 1107**TABLE A12 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES [G]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 0- 7 7- 13 13- 21 21- 27 27- 35 35- 42 42- 49 0- 13

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 3: 100 PPM

------------------------------------------- 91620 18. 27. NA NA NA NA 45. 91628 5. 13. NA NA NA 18. 91631 20. 22. NA NA NA 41. 91636 5. 26. NA NA NA NA 31. 91649 20. 8. NA NA NA 28. 91650 23. 9. NA NA NA 31. 91656 13. 29. NA NA NA NA 41. 91671 31. 14. NA NA NA NA 45. 91675 19. 8. NA NA NA 27. 91677 31. 19. NA NA NA NA 50. 91679 19. 13. NA NA NA 31. 91684 18. 10. NA NA NA 28.

MEAN 18. 16. NA NA NA NA 35. S.D. 8.2 7.8 9.4 S.E. 2.4 2.2 2.7 N 12 12 12

NA = NOT APPLICABLE**Page 560 of 1107**TABLE A12 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES [G]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 0- 7 7- 13 13- 21 21- 27 27- 35 35- 42 42- 49 0- 13

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 4: 175 PPM

------------------------------------------- 91622 -4. 11. NA NA NA 7. 91623 5. 14. 23. 16. 5. -5. 7. 19. 91626 9. 21. NA NA NA NA 30. 91643 11. 17. NA NA NA NA 28. 91654 8. 24. NA NA NA NA 32. 91657 8. 20. 30. NA NA NA NA 27. 91662 12. 26. NA NA NA NA 38. 91666 17. 14. NA NA NA 31. 91676 22. 17. NA NA NA NA 39. 91678 36. 18. NA NA NA 54. 91681 14. 21. 15. NA NA NA NA 35. 91682 14. 16. NA NA NA NA 30.

MEAN 12. 18. 22. 16. 5. -5. 7. 31. S.D. 9.6 4.4 7.5 0.0 0.0 0.0 0.0 11.1 S.E. 2.8 1.3 4.3 0.0 0.0 0.0 0.0 3.2 N 12 12 3 1 1 1 1 12

NA = NOT APPLICABLE**Page 561 of 1107**TABLE A12 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES [G]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 0- 7 7- 13 13- 21 21- 27 27- 35 35- 42 42- 49 0- 13

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 5: 10000 PPM

------------------------------------------- 91624 20. 21. NA NA NA NA 41. 91625 6. 13. NA NA NA NA 18. 91627 0. 5. NA NA NA 5. 91634 12. 13. NA NA NA NA 25. 91635 7. 8. NA NA NA 15. 91638 18. 10. NA NA NA NA 28. 91652 10. 15. NA NA NA 24. 91655 13. 13. NA NA NA 26. 91658 27. 7. NA NA NA 34. 91667 5. 9. NA NA NA 14. 91668 6. 16. NA NA NA 22. 91680 19. 4. NA NA NA 23.

MEAN 12. 11. NA NA NA NA 23. S.D. 7.8 4.9 9.5 S.E. 2.3 1.4 2.7 N 12 12 12

NA = NOT APPLICABLE PJTBWv4.27 01/07/2014**Page 562 of 1107**TABLE A13 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS DURING GESTATION [G]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 0 4 7 11 14 17 20

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91629 G 250. 274. 281. 299. 316. 346. 387. 91630 G 261. 290. 308. 324. 343. 378. 424. 91633 G 289. 311. 323. 353. 368. 404. 446. 91637 G 265. 283. 293. 313. 328. 358. 392. 91639 G 289. 304. 321. 339. 364. 387. 419. 91644 G 253. 289. 296. 321. 337. 374. 415. 91645 G 293. 315. 327. 341. 357. 388. 433. 91648 G 279. 312. 333. 358. 380. 415. 464. 91653 G 262. 299. 304. 323. 348. 375. 418. 91660 G 292. 313. 323. 342. 361. 389. 428. 91670 G 288. 305. 320. 339. 355. 386. 428. 91672 G 305. 334. 344. 375. 385. 425. 475.

MEAN 277. 302. 314. 336. 354. 385. 427. S.D. 18.1 16.4 18.3 20.9 20.3 22.2 25.6 S.E. 5.2 4.7 5.3 6.0 5.9 6.4 7.4 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 563 of 1107**TABLE A13 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS DURING GESTATION [G]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 0 4 7 11 14 17 20

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91632 G 292. 309. 319. 335. 352. 382. 425. 91640 G 292. 313. 326. 341. 363. 387. 433. 91642 G 283. 308. 321. 340. 360. 395. 444. 91647 G 250. 274. 283. 301. 319. 339. 388. 91651 G 280. 299. 315. 327. 341. 372. 415. 91659 G 299. 319. 338. 363. 371. 412. 466. 91661 G 278. 298. 309. 324. 341. 385. 427. 91663 G 278. 305. 326. 340. 352. 387. 438. 91669 G 270. 303. 313. 339. 347. 380. 438. 91673 G 281. 301. 315. 332. 343. 381. 438. 91683 G 263. 298. 308. 329. 343. 359. 404. 91685 G 250. 279. 292. 314. 322. 352. 388.

MEAN 276. 301. 314. 332. 346. 378. 425. S.D. 15.7 12.9 14.9 15.4 15.2 19.7 23.1 S.E. 4.5 3.7 4.3 4.4 4.4 5.7 6.7 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 564 of 1107**TABLE A13 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS DURING GESTATION [G]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 0 4 7 11 14 17 20

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91620 G 292. 317. 333. 351. 367. 396. 445. 91628 G 251. 272. 280. 297. 314. 350. 403. 91631 G 293. 319. 332. 360. 374. 414. 461. 91636 G 244. 283. 294. 308. 323. 352. 394. 91649 G 255. 274. 283. 309. 321. 360. 422. 91650 G 276. 295. 316. 339. 355. 386. 443. 91656 G 313. 324. 325. 345. 359. 389. 432. 91671 G 303. 328. 343. 354. 372. 399. 459. 91675 G 288. 319. 328. 348. 360. 392. 441. 91677 G 276. 294. 314. 316. 333. 351. 367. 91679 G 293. 320. 334. 348. 372. 394. 440. 91684 G 269. 277. 285. 310. 321. 355. 413.

MEAN 279. 302. 314. 332. 348. 378. 427. S.D. 21.5 21.5 22.6 22.2 23.3 22.8 28.0 S.E. 6.2 6.2 6.5 6.4 6.7 6.6 8.1 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 565 of 1107**TABLE A13 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS DURING GESTATION [G]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 0 4 7 11 14 17 20

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 4: 175 PPM

--------------------------------------- 91622 G 253. 280. 287. 306. 320. 348. 397. 91626 G 291. 311. 322. 339. 356. 387. 444. 91643 G 310. 319. 331. 359. 367. 407. 456. 91654 G 279. 298. 310. 324. 338. 371. 428. 91657 G 325. 335. 348. 367. 377. 417. 461. 91662 G 295. 311. 322. 336. 344. 370. 426. 91666 G 249. 269. 273. 296. 305. 333. 370. 91676 G 256. 274. 290. 311. 323. 353. 401. 91678 G 324. 341. 368. 391. 402. 429. 479. 91681 G 292. 304. 315. 334. 342. 373. 434. 91682 G 305. 320. 333. 350. 366. 389. 438.

MEAN 289. 306. 318. 338. 349. 380. 430. S.D. 27.1 23.7 27.7 28.2 28.1 29.7 31.4 S.E. 8.2 7.1 8.3 8.5 8.5 9.0 9.5 N 11 11 11 11 11 11 11

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 566 of 1107**TABLE A13 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS DURING GESTATION [G]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 0 4 7 11 14 17 20

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91624 G 263. 294. 307. 321. 329. 367. 408. 91625 G 256. 273. 281. 299. 313. 338. 387. 91627 G 268. 279. 287. 303. 312. 347. 394. 91634 G 265. 287. 303. 318. 337. 363. 408. 91635 G 271. 296. 307. 330. 345. 383. 428. 91638 G 279. 304. 313. 331. 344. 371. 421. 91652 G 264. 303. 318. 351. 364. 391. 445. 91655 G 258. 289. 299. 316. 328. 365. 415. 91658 G 275. 294. 302. 322. 335. 358. 399. 91667 G 285. 305. 314. 333. 346. 390. 426. 91668 G 275. 297. 313. 337. 356. 394. 441. 91680 G 267. 287. 289. 312. 326. 360. 410.

MEAN 269. 292. 303. 323. 336. 369. 415. S.D. 8.5 9.9 11.8 14.7 15.8 17.7 17.9 S.E. 2.5 2.8 3.4 4.2 4.6 5.1 5.2 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN PGBWv4.09 01/07/2014**Page 567 of 1107**TABLE A14 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES DURING GESTATION [G]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 0- 4 4- 7 7- 11 11- 14 14- 17 17- 20 0- 20

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91629 G 24. 7. 18. 17. 30. 41. 137. 91630 G 29. 18. 16. 19. 35. 46. 163. 91633 G 22. 12. 30. 15. 36. 42. 157. 91637 G 18. 10. 20. 15. 30. 34. 127. 91639 G 15. 17. 18. 25. 23. 32. 130. 91644 G 36. 7. 25. 16. 37. 41. 162. 91645 G 22. 12. 14. 16. 31. 45. 140. 91648 G 33. 21. 25. 22. 35. 49. 185. 91653 G 37. 5. 19. 25. 27. 43. 156. 91660 G 21. 10. 19. 19. 28. 39. 136. 91670 G 17. 15. 19. 16. 31. 42. 140. 91672 G 29. 10. 31. 10. 40. 50. 170.

MEAN 25. 12. 21. 18. 32. 42. 150. S.D. 7.4 4.9 5.4 4.4 4.8 5.3 17.9 S.E. 2.1 1.4 1.6 1.3 1.4 1.5 5.2 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 568 of 1107**TABLE A14 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES DURING GESTATION [G]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 0- 4 4- 7 7- 11 11- 14 14- 17 17- 20 0- 20

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91632 G 17. 10. 16. 17. 30. 43. 133. 91640 G 21. 13. 15. 22. 24. 46. 141. 91642 G 25. 13. 19. 20. 35. 49. 161. 91647 G 24. 9. 18. 18. 20. 49. 138. 91651 G 19. 16. 12. 14. 31. 43. 135. 91659 G 20. 19. 25. 8. 41. 54. 167. 91661 G 20. 11. 15. 17. 44. 42. 149. 91663 G 27. 21. 14. 12. 35. 51. 160. 91669 G 33. 10. 26. 8. 33. 58. 168. 91673 G 20. 14. 17. 11. 38. 57. 157. 91683 G 35. 10. 21. 14. 16. 45. 141. 91685 G 29. 13. 22. 8. 30. 36. 138.

MEAN 24. 13. 18. 14. 31. 48. 149. S.D. 5.8 3.8 4.4 4.8 8.3 6.5 12.9 S.E. 1.7 1.1 1.3 1.4 2.4 1.9 3.7 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 569 of 1107**TABLE A14 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES DURING GESTATION [G]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 0- 4 4- 7 7- 11 11- 14 14- 17 17- 20 0- 20

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91620 G 25. 16. 18. 16. 29. 49. 153. 91628 G 21. 8. 17. 17. 36. 53. 152. 91631 G 26. 13. 28. 14. 40. 47. 168. 91636 G 39. 11. 14. 15. 29. 42. 150. 91649 G 19. 9. 26. 12. 39. 62. 167. 91650 G 19. 21. 23. 16. 31. 57. 167. 91656 G 11. 1. 20. 14. 30. 43. 119. 91671 G 25. 15. 11. 18. 27. 60. 156. 91675 G 31. 9. 20. 12. 32. 49. 153. 91677 G 18. 20. 2. 17. 18. 16. 91. 91679 G 27. 14. 14. 24. 22. 46. 147. 91684 G 8. 8. 25. 11. 34. 58. 144.

MEAN 22. 12. 18. 16. 31. 49. 147. S.D. 8.4 5.6 7.3 3.5 6.4 12.2 22.1 S.E. 2.4 1.6 2.1 1.0 1.9 3.5 6.4 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 570 of 1107**TABLE A14 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES DURING GESTATION [G]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 0- 4 4- 7 7- 11 11- 14 14- 17 17- 20 0- 20

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 4: 175 PPM

--------------------------------------- 91622 G 27. 7. 19. 14. 28. 49. 144. 91626 G 20. 11. 17. 17. 31. 57. 153. 91643 G 9. 12. 28. 8. 40. 49. 146. 91654 G 19. 12. 14. 14. 33. 57. 149. 91657 G 10. 13. 19. 10. 40. 44. 136. 91662 G 16. 11. 14. 8. 26. 56. 131. 91666 G 20. 4. 23. 9. 28. 37. 121. 91676 G 18. 16. 21. 12. 30. 48. 145. 91678 G 17. 27. 23. 11. 27. 50. 155. 91681 G 12. 11. 19. 8. 31. 61. 142. 91682 G 15. 13. 17. 16. 23. 49. 133.

MEAN 17. 12. 19. 12. 31. 51. 141. S.D. 5.1 5.8 4.2 3.3 5.4 6.8 10.2 S.E. 1.6 1.7 1.3 1.0 1.6 2.1 3.1 N 11 11 11 11 11 11 11

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 571 of 1107**TABLE A14 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES DURING GESTATION [G]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 0- 4 4- 7 7- 11 11- 14 14- 17 17- 20 0- 20

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91624 G 31. 13. 14. 8. 38. 41. 145. 91625 G 17. 8. 18. 14. 25. 49. 131. 91627 G 11. 8. 16. 9. 35. 47. 126. 91634 G 22. 16. 15. 19. 26. 45. 143. 91635 G 25. 11. 23. 15. 38. 45. 157. 91638 G 25. 9. 18. 13. 27. 50. 142. 91652 G 39. 15. 33. 13. 27. 54. 181. 91655 G 31. 10. 17. 12. 37. 50. 157. 91658 G 19. 8. 20. 13. 23. 41. 124. 91667 G 20. 9. 19. 13. 44. 36. 141. 91668 G 22. 16. 24. 19. 38. 47. 166. 91680 G 20. 2. 23. 14. 34. 50. 143.

MEAN 24. 10. 20. 14. 33. 46. 146. S.D. 7.4 4.1 5.2 3.3 6.7 5.0 16.6 S.E. 2.1 1.2 1.5 0.9 1.9 1.4 4.8 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN PGBWv4.09 01/07/2014**Page 572 of 1107**TABLE A15 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS DURING LACTATION [G]

-----------------------------------------------------------------------------------------------------------------------------------

DAY 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91629 279. 308. 91630 307. 324. 91633 344. 361. 91637 295. 320. 91639 349. 361. 91644 296. 313. 91645 334. 342. 91648 357. 359. 91653 319. 347. 91660 328. 368. 91670 335. 332. 91672 374. 374.

MEAN 326. 342. S.D. 28.2 22.6 S.E. 8.1 6.5 N 12 12**Page 573 of 1107**TABLE A15 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS DURING LACTATION [G]

-----------------------------------------------------------------------------------------------------------------------------------

DAY 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91632 302. 321. 91640 341. 362. 91642 338. 349. 91647 285. 296. 91651 322. 329. 91659 357. 371. 91661 306. 315. 91663 330. 324. 91669 284. 325. 91673 319. 321. 91683 319. 321. 91685 287. 292.

MEAN 316. 327. S.D. 23.7 23.5 S.E. 6.8 6.8 N 12 12**Page 574 of 1107**TABLE A15 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS DURING LACTATION [G]

-----------------------------------------------------------------------------------------------------------------------------------

DAY 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91620 343. 351. 91628 271. 289. 91631 347. 351. 91636 294. 289. 91649 294. 305. 91650 339. 355. 91656 326. 330. 91671 332. 346. 91675 343. 359. 91677 307. 309. 91679 327. 338. 91684 285. 286.

MEAN 317. 326. S.D. 26.0 28.3 S.E. 7.5 8.2 N 12 12**Page 575 of 1107**TABLE A15 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS DURING LACTATION [G]

-----------------------------------------------------------------------------------------------------------------------------------

DAY 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 4: 175 PPM

--------------------------------------- 91622 285. 301. 91626 335. 367. 91643 346. 360. 91654 316. NA 91657 356. 354. 91662 332. 330. 91666 278. 285. 91676 313. 317. 91678 378. 396. 91681 319. 320. 91682 330. 338.

MEAN 326. 337. S.D. 29.1 33.2 S.E. 8.8 10.5 N 11 10 NA = NOT APPLICABLE**Page 576 of 1107**TABLE A15 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS DURING LACTATION [G]

-----------------------------------------------------------------------------------------------------------------------------------

DAY 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91624 326. 321. 91625 278. 293. 91627 298. 303. 91634 307. 331. 91635 309. 338. 91638 303. 319. 91652 345. 355. 91655 303. 317. 91658 291. 325. 91667 321. 348. 91668 318. 342. 91680 284. 325.

MEAN 307. 326. S.D. 18.7 17.9 S.E. 5.4 5.2 N 12 12 PLBWv4.09 01/07/2014**Page 577 of 1107**TABLE A16 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES DURING LACTATION [G]

-----------------------------------------------------------------------------------------------------------------------------------

DAY 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91629 29. 91630 17. 91633 17. 91637 25. 91639 12. 91644 17. 91645 8. 91648 2. 91653 28. 91660 40. 91670 -3. 91672 0.

MEAN 16. S.D. 13.0 S.E. 3.8 N 12**Page 578 of 1107**TABLE A16 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES DURING LACTATION [G]

-----------------------------------------------------------------------------------------------------------------------------------

DAY 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91632 19. 91640 21. 91642 11. 91647 11. 91651 7. 91659 14. 91661 9. 91663 -6. 91669 41. 91673 2. 91683 2. 91685 5.

MEAN 11. S.D. 12.0 S.E. 3.5 N 12**Page 579 of 1107**TABLE A16 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES DURING LACTATION [G]

-----------------------------------------------------------------------------------------------------------------------------------

DAY 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91620 8. 91628 18. 91631 4. 91636 -5. 91649 11. 91650 16. 91656 4. 91671 14. 91675 16. 91677 2. 91679 11. 91684 1.

MEAN 8. S.D. 7.2 S.E. 2.1 N 12**Page 580 of 1107**TABLE A16 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES DURING LACTATION [G]

-----------------------------------------------------------------------------------------------------------------------------------

DAY 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 4: 175 PPM

--------------------------------------- 91622 16. 91626 32. 91643 14. 91657 -2. 91662 -2. 91666 7. 91676 4. 91678 18. 91681 1. 91682 8.

MEAN 10. S.D. 10.6 S.E. 3.4 N 10 NA = NOT APPLICABLE**Page 581 of 1107**TABLE A16 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES DURING LACTATION [G]

-----------------------------------------------------------------------------------------------------------------------------------

DAY 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91624 -5. 91625 15. 91627 5. 91634 24. 91635 29. 91638 16. 91652 10. 91655 14. 91658 34. 91667 27. 91668 24. 91680 41.

MEAN 20. S.D. 12.9 S.E. 3.7 N 12 PLBWv4.09 01/07/2014**Page 582 of 1107**TABLE A17 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 0- 7 7- 13

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 1: 0 PPM

------------------------------------------- 91555 24. 25. 91560 26. 26. 91562 20. 22. 91563 24. 22. 91564 22. 22. 91567 24. 22. 91579 24. 25. 91586 24. 23. 91591 25. 22. 91592 26. 25. 91609 23. 24. 91615 25. 24.

MEAN 24. 23. S.D. 1.6 1.4 S.E. 0.5 0.4 N 12 12**Page 583 of 1107**TABLE A17 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 0- 7 7- 13

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 2: 50 PPM

------------------------------------------- 91556 23. 23. 91559 21. 20. 91561 23. 25. 91566 24. 22. 91576 22. 23. 91582 29. 27. 91585 25. 25. 91589 20. 21. 91593 24. 24. 91594 23. 24. 91595 27. 26. 91602 25. 27.

MEAN 24. 24. S.D. 2.4 2.3 S.E. 0.7 0.7 N 12 12**Page 584 of 1107**TABLE A17 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 0- 7 7- 13

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 3: 100 PPM

------------------------------------------- 91569 19. 21. 91573 23. 19. 91577 23. 22. 91581 20. 18. 91583 23. 20. 91588 25. 24. 91590 23. 23. 91598 23. 21. 91599 23. 23. 91608 24. 23. 91611 23. 23. 91616 24. 24.

MEAN 23. 22. S.D. 1.7 1.9 S.E. 0.5 0.5 N 12 12**Page 585 of 1107**TABLE A17 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 0- 7 7- 13

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 4: 175 PPM

------------------------------------------- 91565 20. 20. 91568 24. 24. 91570 22. 22. 91572 19. 21. 91580 21. 21. 91584 23. 23. 91587 25. 25. 91597 24. 23. 91601 20. 22. 91607 22. 21. 91613 22. 24. 91614 26. 27.

MEAN 22. 23. S.D. 2.2 1.9 S.E. 0.6 0.6 N 12 12**Page 586 of 1107**TABLE A17 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 0- 7 7- 13

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 5: 10000 PPM

------------------------------------------- 91554 22. 21. 91557 23. 22. 91558 21. 21. 91571 22. 19. 91575 23. 24. 91600 24. 22. 91603 22. 20. 91604 22. 21. 91605 20. 19. 91612 19. 18. 91618 21. 20. 91619 23. 20.

MEAN 22. 21. S.D. 1.4 1.7 S.E. 0.4 0.5 N 12 12 PJTFWv4.26 11/25/2013**Page 587 of 1107**TABLE A18 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 0- 7 7- 13

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 1: 0 PPM

------------------------------------------- 91555 62. 60. 91560 68. 64. 91562 53. 57. 91563 66. 59. 91564 60. 57. 91567 68. 60. 91579 62. 61. 91586 65. 60. 91591 63. 54. 91592 62. 58. 91609 61. 61. 91615 66. 58.

MEAN 63. 59. S.D. 4.2 2.5 S.E. 1.2 0.7 N 12 12**Page 588 of 1107**TABLE A18 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 0- 7 7- 13

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 2: 50 PPM

------------------------------------------- 91556 60. 57. 91559 56. 51. 91561 64. 64. 91566 64. 57. 91576 62. 61. 91582 68. 62. 91585 63. 58. 91589 57. 56. 91593 62. 59. 91594 61. 59. 91595 68. 61. 91602 62. 62.

MEAN 62. 59. S.D. 3.7 3.4 S.E. 1.1 1.0 N 12 12**Page 589 of 1107**TABLE A18 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 0- 7 7- 13

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 3: 100 PPM

------------------------------------------- 91569 50. 55. 91573 63. 50. 91577 64. 58. 91581 51. 46. 91583 60. 53. 91588 64. 58. 91590 59. 55. 91598 62. 55. 91599 64. 61. 91608 63. 57. 91611 59. 54. 91616 63. 60.

MEAN 60. 55. S.D. 4.8 4.2 S.E. 1.4 1.2 N 12 12**Page 590 of 1107**TABLE A18 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 0- 7 7- 13

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 4: 175 PPM

------------------------------------------- 91565 57. 55. 91568 59. 54. 91570 58. 55. 91572 51. 55. 91580 59. 56. 91584 61. 58. 91587 67. 62. 91597 64. 58. 91601 56. 59. 91607 58. 54. 91613 58. 60. 91614 66. 64.

MEAN 59. 58. S.D. 4.6 3.1 S.E. 1.3 0.9 N 12 12**Page 591 of 1107**TABLE A18 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 0- 7 7- 13

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 5: 10000 PPM

------------------------------------------- 91554 61. 56. 91557 59. 54. 91558 55. 53. 91571 63. 53. 91575 59. 60. 91600 60. 53. 91603 59. 52. 91604 56. 54. 91605 56. 53. 91612 54. 51. 91618 58. 55. 91619 63. 55.

MEAN 59. 54. S.D. 2.9 2.4 S.E. 0.8 0.7 N 12 12 PJTFWv4.26 11/25/2013**Page 592 of 1107**

## FINAL **REPORT**

Contents : Volume 3 of 4 Appendix G (continued)

Study Title : An Inhalation Reproduction/Developmental Toxicity

Screening Study

of 2

- Bromo

- 3,3,3

- Trifluoropropene in Rats

Laboratory

Project ID : WI L

- 65501

Author: Tammy e L. Edwards, BS

Test Guideline : OECD Guideline 421

Study Completion Date : 21 March 2014

Performing Laboratory : WI L Research 1407 George Road Ashland, OH 44805

- 8946

Sponsor : American Pacific Corporation 3883 Howard Hughes Parkway , Suite 700 L as Vegas, NV 89169

Total Number of Pages: 1 107

**Page 593 of 1107**

## WI L

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene

American Pacific Corporation



# APPENDIX **G**

Individual Animal Data (continued)

**Page 594 of 1107**TABLE A19 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 0- 7 7- 13 13- 27 27- 35 35- 42 42- 49

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 1: 0 PPM

------------------------------------------- 91629 15. 15. NA NA NA 91630 16. 17. NA NA NA 91633 19. 20. NA NA 91637 19. 19. NA NA 91639 19. 20. NA NA NA 91644 17. 19. NA NA 91645 19. 20. NA NA NA 91648 17. 19. NA NA 91653 18. 21. NA NA NA 91660 20. 19. NA NA NA 91670 20. 18. NA NA NA 91672 21. 21. NA NA NA

MEAN 18. 19. NA NA NA S.D. 1.8 1.6 S.E. 0.5 0.5 N 12 12

NA = NOT APPLICABLE**Page 595 of 1107**TABLE A19 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 0- 7 7- 13 13- 27 27- 35 35- 42 42- 49

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 2: 50 PPM

------------------------------------------- 91632 18. 18. NA NA NA 91640 19. 17. NA NA NA 91642 18. 19. NA NA 91647 16. 15. NA NA NA 91651 19. 17. NA NA NA 91659 18. 21. NA NA 91661 17. 18. NA NA 91663 15. 20. NA NA NA 91669 18. 20. NA NA 91673 17. 18. NA NA NA 91683 17. 17. NA NA NA 91685 16. 17. NA NA

MEAN 17. 18. NA NA NA S.D. 1.2 1.7 S.E. 0.3 0.5 N 12 12

NA = NOT APPLICABLE**Page 596 of 1107**TABLE A19 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 0- 7 7- 13 13- 27 27- 35 35- 42 42- 49

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 3: 100 PPM

------------------------------------------- 91620 18. 20. NA NA NA 91628 14. 16. NA NA 91631 18. 22. NA NA 91636 14. 17. NA NA NA 91649 16. 17. NA NA 91650 19. 19. NA NA 91656 17. 21. NA NA NA 91671 19. 20. NA NA NA 91675 18. 19. NA NA 91677 18. 19. NA NA NA 91679 19. 20. NA NA 91684 16. 18. NA NA

MEAN 17. 19. NA NA NA S.D. 1.9 1.8 S.E. 0.5 0.5 N 12 12

NA = NOT APPLICABLE**Page 597 of 1107**TABLE A19 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 0- 7 7- 13 13- 27 27- 35 35- 42 42- 49

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 4: 175 PPM

------------------------------------------- 91622 15. 16. NA NA 91623 16. 17. NA 19. 16. 16. 91626 17. 19. NA NA NA 91643 18. 19. NA NA NA 91654 18. 21. NA NA NA 91657 17. 19. NA NA NA NA 91662 18. 20. NA NA NA 91666 15. 17. NA NA 91676 16. 17. NA NA NA 91678 13. 23. NA NA 91681 17. 18. NA NA NA NA 91682 18. 19. NA NA NA

MEAN 17. 19. NA 19. 16. 16. S.D. 1.6 1.8 0.0 0.0 0.0 S.E. 0.5 0.5 0.0 0.0 0.0 N 12 12 1 1 1

NA = NOT APPLICABLE**Page 598 of 1107**TABLE A19 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 0- 7 7- 13 13- 27 27- 35 35- 42 42- 49

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 5: 10000 PPM

------------------------------------------- 91624 16. 18. NA NA NA 91625 16. 16. NA NA NA 91627 15. 16. NA NA 91634 17. 17. NA NA NA 91635 16. 17. NA NA 91638 17. 19. NA NA NA 91652 16. 19. NA NA 91655 17. 18. NA NA 91658 17. 18. NA NA 91667 18. 19. NA NA 91668 18. 19. NA NA 91680 17. 17. NA NA

MEAN 16. 18. NA NA NA S.D. 0.9 1.2 S.E. 0.3 0.3 N 12 12

NA = NOT APPLICABLE PJTFWv4.26 01/07/2014**Page 599 of 1107**TABLE A20 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 0- 7 7- 13 13- 27 27- 35 35- 42 42- 49

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 1: 0 PPM

------------------------------------------- 91629 63. 62. NA NA NA 91630 62. 66. NA NA NA 91633 69. 69. NA NA 91637 78. 73. NA NA 91639 71. 71. NA NA NA 91644 70. 74. NA NA 91645 71. 70. NA NA NA 91648 65. 70. NA NA 91653 70. 78. NA NA NA 91660 77. 68. NA NA NA 91670 75. 68. NA NA NA 91672 78. 73. NA NA NA

MEAN 71. 70. NA NA NA S.D. 5.5 4.0 S.E. 1.6 1.2 N 12 12

NA = NOT APPLICABLE**Page 600 of 1107**TABLE A20 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 0- 7 7- 13 13- 27 27- 35 35- 42 42- 49

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 2: 50 PPM

------------------------------------------- 91632 69. 64. NA NA NA 91640 68. 61. NA NA NA 91642 69. 67. NA NA 91647 67. 61. NA NA NA 91651 71. 61. NA NA NA 91659 66. 71. NA NA 91661 70. 68. NA NA 91663 64. 78. NA NA NA 91669 70. 73. NA NA 91673 65. 66. NA NA NA 91683 70. 68. NA NA NA 91685 67. 68. NA NA

MEAN 68. 67. NA NA NA S.D. 2.3 5.1 S.E. 0.7 1.5 N 12 12

NA = NOT APPLICABLE**Page 601 of 1107**TABLE A20 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 0- 7 7- 13 13- 27 27- 35 35- 42 42- 49

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 3: 100 PPM

------------------------------------------- 91620 69. 71. NA NA NA 91628 59. 64. NA NA 91631 69. 76. NA NA 91636 59. 70. NA NA NA 91649 68. 70. NA NA 91650 72. 71. NA NA 91656 66. 73. NA NA NA 91671 75. 73. NA NA NA 91675 68. 67. NA NA 91677 74. 73. NA NA NA 91679 70. 68. NA NA 91684 65. 66. NA NA

MEAN 68. 70. NA NA NA S.D. 5.1 3.4 S.E. 1.5 1.0 N 12 12

NA = NOT APPLICABLE**Page 602 of 1107**TABLE A20 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 0- 7 7- 13 13- 27 27- 35 35- 42 42- 49

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 4: 175 PPM

------------------------------------------- 91622 59. 62. NA NA 91623 60. 65. NA 60. 52. 51. 91626 64. 67. NA NA NA 91643 67. 67. NA NA NA 91654 75. 80. NA NA NA 91657 63. 67. NA NA NA NA 91662 70. 70. NA NA NA 91666 63. 69. NA NA 91676 70. 69. NA NA NA 91678 47. 73. NA NA 91681 67. 66. NA NA NA NA 91682 64. 66. NA NA NA

MEAN 64. 68. NA 60. 52. 51. S.D. 7.0 4.6 0.0 0.0 0.0 S.E. 2.0 1.3 0.0 0.0 0.0 N 12 12 1 1 1

NA = NOT APPLICABLE**Page 603 of 1107**TABLE A20 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 0- 7 7- 13 13- 27 27- 35 35- 42 42- 49

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 5: 10000 PPM

------------------------------------------- 91624 66. 69. NA NA NA 91625 65. 62. NA NA NA 91627 58. 62. NA NA 91634 70. 67. NA NA NA 91635 60. 60. NA NA 91638 67. 70. NA NA NA 91652 64. 74. NA NA 91655 68. 69. NA NA 91658 65. 65. NA NA 91667 65. 66. NA NA 91668 70. 72. NA NA 91680 66. 64. NA NA

MEAN 65. 67. NA NA NA S.D. 3.5 4.3 S.E. 1.0 1.2 N 12 12

NA = NOT APPLICABLE PJTFWv4.26 01/07/2014**Page 604 of 1107**TABLE A21 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 0- 4 4- 7 7-11 11-14 14-17 17-20 0-20

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91629 G 20. 20. 20. 21. 23. 22. 21. 91630 G 20. 23. 23. 23. 26. 25. 23. 91633 G 17. 21. 25. 26. 28. 27. 24. 91637 G 20. 20. 21. 23. 25. 23. 22. 91639 G 19. 23. 24. 26. 26. 26. 24. 91644 G 22. 22. 22. 23. 27. 26. 24. 91645 G 20. 24. 25. 24. 23. 24. 23. 91648 G 22. 26. 26. 28. 30. 29. 27. 91653 G 22. 21. 23. 25. 24. 27. 24. 91660 G 20. 20. 22. 22. 24. 23. 22. 91670 G 19. 21. 25. 26. 27. 26. 24. 91672 G 23. 26. 28. 27. 30. 29. 27.

MEAN 20. 22. 24. 25. 26. 26. 24. S.D. 1.7 2.2 2.3 2.2 2.4 2.3 1.8 S.E. 0.5 0.6 0.7 0.6 0.7 0.7 0.5 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 605 of 1107**TABLE A21 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 0- 4 4- 7 7-11 11-14 14-17 17-20 0-20

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91632 G 19. 20. 21. 23. 24. 24. 22. 91640 G 19. 20. 21. 24. 27. 27. 23. 91642 G 21. 23. 25. 24. 26. 29. 24. 91647 G 17. 20. 19. 23. 22. 25. 21. 91651 G 19. 21. 20. 22. 23. 24. 21. 91659 G 19. 23. 25. 24. 29. 31. 25. 91661 G 21. 24. 22. 24. 26. 24. 23. 91663 G 22. 22. 25. 24. 26. 29. 24. 91669 G 22. 24. 24. 23. 25. 27. 24. 91673 G 18. 21. 22. 24. 27. 28. 23. 91683 G 20. 22. 23. 24. 25. 25. 23. 91685 G 21. 22. 24. 24. 25. 24. 23.

MEAN 20. 22. 23. 24. 25. 26. 23. S.D. 1.6 1.5 2.1 0.7 1.9 2.4 1.2 S.E. 0.5 0.4 0.6 0.2 0.5 0.7 0.3 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 606 of 1107**TABLE A21 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 0- 4 4- 7 7-11 11-14 14-17 17-20 0-20

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91620 G 22. 22. 24. 23. 25. 26. 23. 91628 G 17. 18. 19. 20. 23. 24. 20. 91631 G 22. 26. 25. 27. 31. 29. 26. 91636 G 21. 21. 22. 21. 23. 24. 22. 91649 G 20. 24. 22. 24. 25. 27. 23. 91650 G 18. 22. 24. 26. 25. 28. 23. 91656 G 18. 20. 20. 22. 23. 22. 21. 91671 G 22. 26. 24. 25. 27. 29. 25. 91675 G 19. 24. 23. 24. 29. 29. 24. 91677 G 19. 23. 23. 20. 24. 24. 22. 91679 G 19. 24. 25. 26. 26. 29. 24. 91684 G 13. 19. 20. 20. 23. 24. 19.

MEAN 19. 22. 23. 23. 25. 26. 23. S.D. 2.6 2.6 2.0 2.6 2.6 2.6 2.0 S.E. 0.7 0.7 0.6 0.7 0.7 0.7 0.6 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 607 of 1107**TABLE A21 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 0- 4 4- 7 7-11 11-14 14-17 17-20 0-20

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 4: 175 PPM

--------------------------------------- 91622 G 16. 20. 19. 21. 23. 24. 20. 91626 G 18. 21. 22. 24. 25. 28. 23. 91643 G 17. 22. 23. 24. 29. 31. 24. 91654 G 20. 22. 23. 22. 24. 29. 23. 91657 G 17. 22. 22. 23. 27. 28. 23. 91662 G 17. 22. 22. 21. 23. 25. 21. 91666 G 16. 17. 19. 21. 22. 23. 19. 91676 G 18. 22. 22. 23. 25. 28. 23. 91678 G 21. 27. 29. 29. 27. 29. 27. 91681 G 16. 18. 20. 21. 23. 26. 20. 91682 G 20. 22. 22. 23. 24. 29. 23.

MEAN 18. 21. 22. 23. 25. 27. 22. S.D. 1.8 2.6 2.7 2.3 2.1 2.5 2.2 S.E. 0.5 0.8 0.8 0.7 0.6 0.7 0.7 N 11 11 11 11 11 11 11

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 608 of 1107**TABLE A21 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 0- 4 4- 7 7-11 11-14 14-17 17-20 0-20

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91624 G 19. 22. 22. 22. 26. 25. 22. 91625 G 17. 19. 19. 20. 22. 22. 20. 91627 G 15. 17. 19. 21. 24. 24. 20. 91634 G 20. 22. 21. 22. 25. 27. 23. 91635 G 16. 19. 20. 22. 24. 24. 20. 91638 G 22. 23. 25. 23. 25. 25. 24. 91652 G 23. 25. 26. 28. 30. 30. 27. 91655 G 19. 22. 21. 23. 27. 28. 23. 91658 G 16. 20. 21. 20. 21. 22. 20. 91667 G 19. 21. 21. 21. 24. 22. 21. 91668 G 21. 24. 23. 25. 27. 26. 24. 91680 G 17. 17. 19. 22. 24. 25. 20.

MEAN 19. 21. 21. 22. 25. 25. 22. S.D. 2.5 2.6 2.3 2.2 2.4 2.5 2.3 S.E. 0.7 0.7 0.7 0.6 0.7 0.7 0.7 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN PGFWv4.11 01/07/2014**Page 609 of 1107**TABLE A22 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING GESTATION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 0- 4 4- 7 7-11 11-14 14-17 17-20 0-20

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91629 G 76. 72. 69. 68. 69. 60. 68. 91630 G 72. 77. 73. 69. 72. 62. 69. 91633 G 57. 66. 74. 72. 73. 64. 67. 91637 G 73. 69. 69. 72. 73. 61. 69. 91639 G 64. 73. 73. 74. 69. 65. 69. 91644 G 81. 75. 71. 70. 76. 66. 74. 91645 G 66. 75. 75. 69. 62. 58. 66. 91648 G 74. 80. 75. 76. 75. 66. 74. 91653 G 78. 70. 73. 74. 66. 68. 72. 91660 G 66. 63. 66. 63. 64. 56. 63. 91670 G 64. 67. 76. 75. 73. 64. 69. 91672 G 72. 77. 78. 71. 74. 64. 71.

MEAN 70. 72. 73. 71. 71. 63. 69. S.D. 6.9 5.1 3.4 3.6 4.5 3.5 3.2 S.E. 2.0 1.5 1.0 1.0 1.3 1.0 0.9 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 610 of 1107**TABLE A22 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING GESTATION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 0- 4 4- 7 7-11 11-14 14-17 17-20 0-20

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91632 G 63. 64. 64. 67. 65. 59. 64. 91640 G 63. 63. 63. 68. 72. 66. 66. 91642 G 71. 73. 76. 69. 69. 69. 69. 91647 G 65. 72. 65. 74. 67. 69. 68. 91651 G 66. 68. 62. 66. 64. 61. 63. 91659 G 61. 70. 71. 65. 74. 71. 68. 91661 G 73. 79. 69. 72. 72. 59. 68. 91663 G 75. 70. 75. 69. 70. 70. 69. 91669 G 77. 78. 74. 67. 69. 66. 70. 91673 G 62. 68. 68. 71. 75. 68. 67. 91683 G 71. 73. 72. 71. 71. 65. 70. 91685 G 79. 77. 79. 75. 74. 65. 73.

MEAN 69. 71. 70. 70. 70. 66. 68. S.D. 6.3 5.1 5.6 3.1 3.5 4.1 2.7 S.E. 1.8 1.5 1.6 0.9 1.0 1.2 0.8 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 611 of 1107**TABLE A22 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING GESTATION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 0- 4 4- 7 7-11 11-14 14-17 17-20 0-20

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91620 G 72. 68. 70. 64. 65. 62. 64. 91628 G 65. 65. 66. 65. 69. 64. 65. 91631 G 72. 80. 72. 74. 79. 66. 71. 91636 G 80. 73. 73. 66. 68. 64. 70. 91649 G 75. 86. 74. 76. 73. 69. 72. 91650 G 63. 72. 73. 75. 67. 67. 67. 91656 G 56. 62. 60. 63. 61. 54. 59. 91671 G 70. 77. 69. 69. 70. 68. 68. 91675 G 63. 74. 68. 68. 77. 70. 68. 91677 G 67. 76. 73. 62. 70. 67. 68. 91679 G 62. 73. 73. 72. 68. 70. 67. 91684 G 48. 68. 67. 63. 68. 63. 60.

MEAN 66. 73. 70. 68. 70. 65. 67. S.D. 8.7 6.6 4.1 5.1 4.9 4.5 4.0 S.E. 2.5 1.9 1.2 1.5 1.4 1.3 1.2 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 612 of 1107**TABLE A22 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING GESTATION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 0- 4 4- 7 7-11 11-14 14-17 17-20 0-20

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 4: 175 PPM

--------------------------------------- 91622 G 60. 70. 64. 67. 69. 64. 64. 91626 G 60. 66. 66. 69. 67. 67. 66. 91643 G 54. 68. 67. 66. 75. 72. 66. 91654 G 69. 72. 73. 66. 68. 73. 69. 91657 G 52. 64. 61. 62. 68. 64. 61. 91662 G 56. 69. 67. 62. 64. 63. 61. 91666 G 62. 63. 67. 70. 69. 65. 64. 91676 G 68. 78. 73. 73. 74. 74. 73. 91678 G 63. 76. 76. 73. 65. 64. 69. 91681 G 54. 58. 62. 62. 64. 64. 58. 91682 G 64. 67. 64. 64. 63. 70. 64.

MEAN 60. 68. 67. 67. 68. 67. 65. S.D. 5.7 5.7 4.8 4.1 3.9 4.2 4.3 S.E. 1.7 1.7 1.5 1.2 1.2 1.3 1.3 N 11 11 11 11 11 11 11

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 613 of 1107**TABLE A22 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING GESTATION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 0- 4 4- 7 7-11 11-14 14-17 17-20 0-20

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91624 G 68. 73. 70. 68. 75. 64. 67. 91625 G 64. 69. 66. 65. 67. 61. 65. 91627 G 55. 60. 64. 68. 73. 65. 64. 91634 G 72. 75. 68. 67. 71. 70. 71. 91635 G 56. 63. 63. 65. 66. 59. 59. 91638 G 75. 74. 78. 68. 70. 63. 71. 91652 G 81. 80. 78. 78. 79. 72. 78. 91655 G 69. 75. 68. 71. 78. 72. 71. 91658 G 56. 67. 67. 61. 61. 58. 61. 91667 G 64. 68. 65. 62. 65. 54. 61. 91668 G 73. 79. 71. 72. 72. 62. 70. 91680 G 61. 59. 63. 69. 70. 65. 62.

MEAN 66. 70. 68. 68. 71. 64. 67. S.D. 8.3 7.0 5.1 4.6 5.3 5.6 5.6 S.E. 2.4 2.0 1.5 1.3 1.5 1.6 1.6 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN PGFWv4.11 01/07/2014**Page 614 of 1107**TABLE A23 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING LACTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

DAY 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91629 29. 91630 29. 91633 29. 91637 30. 91639 30. 91644 23. 91645 35. 91648 29. 91653 50. 91660 34. 91670 31. 91672 37.

MEAN 32. S.D. 6.7 S.E. 1.9 N 12**Page 615 of 1107**TABLE A23 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING LACTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

DAY 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91632 29. 91640 32. 91642 33. 91647 21. 91651 39. 91659 30. 91661 32. 91663 33. 91669 32. 91673 25. 91683 28. 91685 22.

MEAN 30. S.D. 5.1 S.E. 1.5 N 12**Page 616 of 1107**TABLE A23 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING LACTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

DAY 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91620 46. 91628 27. 91631 35. 91636 24. 91649 37. 91650 32. 91656 29. 91671 28. 91675 34. 91677 16. 91679 26. 91684 19.

MEAN 29. S.D. 8.1 S.E. 2.3 N 12**Page 617 of 1107**TABLE A23 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING LACTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

DAY 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 4: 175 PPM

--------------------------------------- 91622 24. 91626 38. 91643 29. 91654 NA 91657 22. 91662 22. 91666 26. 91676 29. 91678 38. 91681 28. 91682 19.

MEAN 28. S.D. 6.4 S.E. 2.0 N 10 NA = NOT APPLICABLE**Page 618 of 1107**TABLE A23 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING LACTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

DAY 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91624 30. 91625 40. 91627 30. 91634 38. 91635 36. 91638 35. 91652 43. 91655 30. 91658 40. 91667 38. 91668 29. 91680 37.

MEAN 36. S.D. 4.7 S.E. 1.4 N 12 PLFWv4.13 01/07/2014**Page 619 of 1107**TABLE A24 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING LACTATION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

DAY 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91629 99. 91630 92. 91633 82. 91637 97. 91639 85. 91644 75. 91645 104. 91648 81. 91653 150. 91660 98. 91670 93. 91672 99.

MEAN 96. S.D. 19.1 S.E. 5.5 N 12**Page 620 of 1107**TABLE A24 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING LACTATION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

DAY 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91632 93. 91640 91. 91642 96. 91647 72. 91651 120. 91659 82. 91661 103. 91663 101. 91669 105. 91673 78. 91683 88. 91685 76.

MEAN 92. S.D. 14.0 S.E. 4.0 N 12**Page 621 of 1107**TABLE A24 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING LACTATION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

DAY 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91620 133. 91628 96. 91631 100. 91636 82. 91649 123. 91650 92. 91656 88. 91671 83. 91675 97. 91677 52. 91679 78. 91684 66.

MEAN 91. S.D. 22.2 S.E. 6.4 N 12**Page 622 of 1107**TABLE A24 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING LACTATION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

DAY 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 4: 175 PPM

--------------------------------------- 91622 82. 91626 108. 91643 82. 91654 NA 91657 62. 91662 66. 91666 92. 91676 92. 91678 98. 91681 88. 91682 57.

MEAN 83. S.D. 16.5 S.E. 5.2 N 10 NA = NOT APPLICABLE**Page 623 of 1107**TABLE A24 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING LACTATION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

DAY 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91624 93. 91625 140. 91627 100. 91634 119. 91635 111. 91638 113. 91652 123. 91655 97. 91658 130. 91667 113. 91668 88. 91680 121.

MEAN 112. S.D. 15.6 S.E. 4.5 N 12 PLFWv4.13 01/07/2014**Page 624 of 1107**TABLE A25 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 0- 1 1- 2 2- 3 3- 4 4- 5 5- 6 6- 7 7- 8 8- 9 9- 10 10- 11 11- 12

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 1: 0 PPM

------------------------------------------- 91555 50. 52. 77. 39. 36. 53. NA 37. 36. 38. 81. 29. 91560 41. 43. 60. 47. 44. 54. 99. 41. 44. 50. 38. 36. 91562 39. 44. 49. 40. 43. 47. 60. 54. 42. 34. 47. 46. 91563 33. 37. 44. 37. 33. 33. 37. 37. 33. 34. 46. 28. 91564 36. 36. 34. 32. 30. 29. 33. 32. 36. 34. 32. 35. 91567 32. 33. 32. 39. 31. 27. 33. 28. 27. 28. 31. 31. 91579 41. 52. 71. 51. 49. 69. NA 44. 48. 45. 41. 47. 91586 46. 45. 58. 39. 37. 45. 53. 48. 39. 35. 44. 34. 91591 42. 43. 51. 38. 35. 41. 43. 32. 33. 31. 39. 32. 91592 34. 35. 36. 39. 33. 33. 36. 32. 42. 31. 38. 37. 91609 35. 40. 35. 41. 33. 40. 37. 39. 38. 39. 38. 38. 91615 37. 35. 36. 32. 32. 36. 33. 37. 30. 29. 37. 21.

MEAN 39. 41. 49. 40. 36. 42. 46. 38. 37. 36. 43. 35. S.D. 5.5 6.4 15.2 5.4 6.0 12.0 20.7 7.4 6.1 6.7 12.9 7.1 S.E. 1.6 1.8 4.4 1.6 1.7 3.5 6.5 2.1 1.8 1.9 3.7 2.1 N 12 12 12 12 12 12 10 12 12 12 12 12

NA = NOT APPLICABLE**Page 625 of 1107**TABLE A25 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 12- 13 0- 7 0- 13

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 1: 0 PPM

------------------------------------------- 91555 32. 51. 47. 91560 34. 56. 49. 91562 36. 46. 45. 91563 31. 36. 36. 91564 34. 33. 33. 91567 31. 32. 31. 91579 37. 55. 50. 91586 34. 46. 43. 91591 32. 42. 38. 91592 36. 35. 36. 91609 37. 37. 38. 91615 37. 34. 33.

MEAN 34. 42. 40. S.D. 2.4 8.6 6.4 S.E. 0.7 2.5 1.9 N 12 12 12**Page 626 of 1107**TABLE A25 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 0- 1 1- 2 2- 3 3- 4 4- 5 5- 6 6- 7 7- 8 8- 9 9- 10 10- 11 11- 12

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 2: 50 PPM

------------------------------------------- 91556 44. 52. 73. 44. 49. 58. 80. 39. 56. 36. 34. 39. 91559 29. 35. 39. 30. 33. 26. 41. 28. 41. 29. 26. 25. 91561 27. 40. 34. 45. 35. 44. 55. 37. 39. 38. 38. 35. 91566 32. 37. 36. 36. 36. 33. 37. 33. 34. 31. 32. 34. 91576 29. 34. 34. 30. 30. 28. 33. 31. 36. 29. 31. 27. 91582 50. 44. 43. 42. 41. 38. 40. 37. 45. 35. 33. 40. 91585 35. 52. 74. 44. 41. 49. 81. 51. 35. 36. 39. 43. 91589 33. 37. 37. 36. 31. 32. 46. 49. 38. 32. 40. 53. 91593 41. 40. 41. 37. 37. 35. 46. 43. 37. 34. 40. 52. 91594 34. 40. 37. 37. 33. 32. 32. 34. 36. 31. 35. 36. 91595 38. 38. 38. 38. 38. 40. 40. 39. 41. 37. 38. 42. 91602 34. 41. 39. 38. 38. 36. 40. 40. 43. 35. 39. 46.

MEAN 35. 41. 44. 38. 37. 38. 47. 38. 40. 34. 35. 39. S.D. 6.7 5.8 14.0 5.0 5.1 9.3 16.4 6.9 5.8 3.1 4.3 8.6 S.E. 1.9 1.7 4.0 1.4 1.5 2.7 4.7 2.0 1.7 0.9 1.2 2.5 N 12 12 12 12 12 12 12 12 12 12 12 12**Page 627 of 1107**TABLE A25 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 12- 13 0- 7 0- 13

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 2: 50 PPM

------------------------------------------- 91556 47. 57. 50. 91559 28. 33. 32. 91561 39. 40. 39. 91566 33. 35. 34. 91576 37. 31. 32. 91582 43. 43. 41. 91585 48. 54. 48. 91589 38. 36. 39. 91593 33. 40. 40. 91594 37. 35. 35. 91595 38. 38. 39. 91602 39. 38. 39.

MEAN 39. 40. 39. S.D. 5.7 7.9 5.8 S.E. 1.6 2.3 1.7 N 12 12 12**Page 628 of 1107**TABLE A25 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 0- 1 1- 2 2- 3 3- 4 4- 5 5- 6 6- 7 7- 8 8- 9 9- 10 10- 11 11- 12

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 3: 100 PPM

------------------------------------------- 91569 29. 34. 37. 26. 29. 30. 41. 45. 34. 31. 47. 46. 91573 43. 42. 46. 42. 56. 55. 62. 56. 51. 41. 36. 30. 91577 36. 44. 39. 37. 33. 30. 38. 29. 35. 28. 34. 32. 91581 35. 39. 26. 32. 32. 37. 36. 36. 31. 33. 32. 34. 91583 42. 47. 40. 35. 35. 35. 31. 31. 35. 35. 33. 33. 91588 40. 37. 41. 35. 35. 30. 33. 32. 38. 36. 35. 26. 91590 44. 49. 32. 48. 48. 46. 39. 44. 32. 34. 36. 56. 91598 31. 38. 41. 35. 36. 37. 57. 40. 31. 29. 31. 29. 91599 30. 35. 35. 37. 35. 36. 40. 35. 35. 26. 34. 32. 91608 35. 33. 37. 36. 36. 33. 27. 33. 32. 37. 35. 38. 91611 27. 36. 28. 36. 39. 33. 38. 29. 33. 27. 35. 32. 91616 38. 58. 59. 44. 53. 42. 54. 55. 42. 40. 56. 39.

MEAN 36. 41. 38. 37. 39. 37. 41. 39. 36. 33. 37. 36. S.D. 5.7 7.3 8.8 5.8 8.5 7.5 10.9 9.4 5.8 4.9 7.2 8.3 S.E. 1.6 2.1 2.5 1.7 2.5 2.2 3.1 2.7 1.7 1.4 2.1 2.4 N 12 12 12 12 12 12 12 12 12 12 12 12**Page 629 of 1107**TABLE A25 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 12- 13 0- 7 0- 13

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 3: 100 PPM

------------------------------------------- 91569 29. 32. 35. 91573 38. 50. 46. 91577 32. 37. 34. 91581 32. 34. 33. 91583 31. 38. 36. 91588 37. 36. 35. 91590 35. 44. 42. 91598 48. 39. 37. 91599 44. 35. 35. 91608 39. 34. 35. 91611 36. 34. 33. 91616 44. 50. 48.

MEAN 37. 38. 37. S.D. 5.9 6.0 5.0 S.E. 1.7 1.7 1.5 N 12 12 12**Page 630 of 1107**TABLE A25 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 0- 1 1- 2 2- 3 3- 4 4- 5 5- 6 6- 7 7- 8 8- 9 9- 10 10- 11 11- 12

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 4: 175 PPM

------------------------------------------- 91565 32. 58. 79. 45. 44. 51. 70. 54. 37. 36. 39. 32. 91568 33. 41. 44. 35. 41. 44. 57. 43. 37. 28. 34. 36. 91570 38. 34. 42. 38. 37. 35. 42. 36. 38. 34. 36. 33. 91572 37. 39. 33. 37. 34. 34. 34. 35. 42. 31. 28. 30. 91580 33. 33. 34. 33. 33. 33. 36. 28. 36. 26. 36. 27. 91584 41. 51. 49. 51. 47. 41. 43. 38. 47. 50. 53. 40. 91587 49. 55. 64. 49. 54. 70. NA 52. 87. 40. 48. 43. 91597 59. 69. 81. 62. 65. 72. 83. 57. 58. 50. 53. 55. 91601 41. 45. 46. 46. 46. 47. 52. 45. 52. 54. 46. 43. 91607 31. 39. 32. 36. 34. 33. 36. 34. 35. 37. 35. 37. 91613 35. 36. 33. 32. 29. 32. 38. 32. 38. 34. 35. 36. 91614 31. 50. 45. 48. 51. 38. 51. 40. 42. 39. 43. 43.

MEAN 38. 46. 48. 43. 43. 44. 49. 41. 46. 38. 40. 38. S.D. 8.3 11.0 17.1 9.1 10.3 14.0 15.7 9.1 14.6 8.9 8.0 7.4 S.E. 2.4 3.2 4.9 2.6 3.0 4.0 4.7 2.6 4.2 2.6 2.3 2.1 N 12 12 12 12 12 12 11 12 12 12 12 12

NA = NOT APPLICABLE**Page 631 of 1107**TABLE A25 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 12- 13 0- 7 0- 13

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 4: 175 PPM

------------------------------------------- 91565 53. 54. 48. 91568 29. 42. 39. 91570 51. 38. 38. 91572 46. 35. 35. 91580 37. 34. 33. 91584 44. 46. 46. 91587 49. 57. 55. 91597 53. 70. 63. 91601 53. 46. 47. 91607 45. 34. 36. 91613 39. 34. 35. 91614 41. 45. 43.

MEAN 45. 45. 43. S.D. 7.5 11.2 9.2 S.E. 2.2 3.2 2.6 N 12 12 12**Page 632 of 1107**TABLE A25 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 0- 1 1- 2 2- 3 3- 4 4- 5 5- 6 6- 7 7- 8 8- 9 9- 10 10- 11 11- 12

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 5: 10000 PPM

------------------------------------------- 91554 36. 34. 43. 34. 35. 49. 72. 36. NA 28. 32. 33. 91557 40. 50. 60. 49. 42. 52. 53. 55. 51. 49. 45. 54. 91558 33. 40. 46. 35. 35. 38. 47. 42. 38. 38. 42. 42. 91571 31. 32. 28. 26. 29. 27. 27. 24. 27. 15. 27. 26. 91575 32. 38. 37. 34. 37. 37. 38. 40. 41. 36. 38. 40. 91600 40. 50. 46. 37. 39. 36. 38. 36. 40. 42. 36. 38. 91603 38. 52. 66. 40. 43. 52. 80. 59. 33. 27. 28. 56. 91604 36. 39. 46. 34. 39. 44. 64. 43. 52. 35. 47. 52. 91605 31. 31. 39. 33. 27. 32. 39. 34. 32. 26. 33. 37. 91612 33. 30. 33. 32. 29. 27. 31. 26. 30. 33. 31. 32. 91618 29. 37. 32. 30. 34. 27. 31. 30. 36. 23. 35. 34. 91619 32. 35. 37. 35. 38. 32. 33. 35. 34. 28. 32. 34.

MEAN 34. 39. 43. 35. 36. 38. 46. 38. 38. 32. 35. 40. S.D. 3.7 7.7 11.3 5.7 5.1 9.5 17.4 10.6 8.2 9.1 6.3 9.5 S.E. 1.1 2.2 3.2 1.7 1.5 2.7 5.0 3.1 2.5 2.6 1.8 2.7 N 12 12 12 12 12 12 12 12 11 12 12 12

NA = NOT APPLICABLE**Page 633 of 1107**TABLE A25 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 12- 13 0- 7 0- 13

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 5: 10000 PPM

------------------------------------------- 91554 63. 43. 41. 91557 41. 50. 49. 91558 51. 39. 40. 91571 32. 29. 27. 91575 38. 36. 37. 91600 43. 41. 40. 91603 65. 53. 49. 91604 39. 43. 44. 91605 38. 33. 33. 91612 39. 31. 31. 91618 33. 31. 32. 91619 34. 35. 34.

MEAN 43. 39. 38. S.D. 11.0 7.6 7.1 S.E. 3.2 2.2 2.1 N 12 12 12 PJTFWv4.26 01/20/2014**Page 634 of 1107**TABLE A26 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 0- 7 7- 13

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 1: 0 PPM

------------------------------------------- 91555 131. 102. 91560 148. 103. 91562 122. 111. 91563 100. 92. 91564 88. 88. 91567 91. 80. 91579 142. 107. 91586 125. 101. 91591 108. 82. 91592 86. 82. 91609 101. 99. 91615 90. 78.

MEAN 111. 94. S.D. 21.9 11.6 S.E. 6.3 3.4 N 12 12**Page 635 of 1107**TABLE A26 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 0- 7 7- 13

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 2: 50 PPM

------------------------------------------- 91556 150. 103. 91559 88. 77. 91561 110. 95. 91566 96. 86. 91576 87. 84. 91582 101. 88. 91585 134. 99. 91589 103. 113. 91593 102. 97. 91594 92. 87. 91595 95. 92. 91602 94. 94.

MEAN 104. 93. S.D. 19.1 9.6 S.E. 5.5 2.8 N 12 12**Page 636 of 1107**TABLE A26 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 0- 7 7- 13

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 3: 100 PPM

------------------------------------------- 91569 87. 102. 91573 134. 111. 91577 102. 84. 91581 84. 83. 91583 99. 86. 91588 90. 82. 91590 112. 97. 91598 107. 90. 91599 99. 91. 91608 90. 89. 91611 86. 77. 91616 129. 114.

MEAN 101. 92. S.D. 16.4 11.5 S.E. 4.7 3.3 N 12 12**Page 637 of 1107**TABLE A26 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 0- 7 7- 13

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 4: 175 PPM

------------------------------------------- 91565 155. 116. 91568 101. 80. 91570 100. 95. 91572 94. 92. 91580 94. 84. 91584 124. 116. 91587 151. 129. 91597 187. 139. 91601 128. 129. 91607 90. 94. 91613 88. 91. 91614 114. 98.

MEAN 119. 105. S.D. 31.3 19.6 S.E. 9.0 5.7 N 12 12**Page 638 of 1107**TABLE A26 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- MALES DAY 0- 7 7- 13

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 5: 10000 PPM

------------------------------------------- 91554 120. 103. 91557 127. 122. 91558 102. 107. 91571 83. 71. 91575 93. 95. 91600 101. 94. 91603 141. 117. 91604 111. 114. 91605 95. 93. 91612 87. 90. 91618 85. 86. 91619 96. 88.

MEAN 103. 98. S.D. 18.0 14.7 S.E. 5.2 4.3 N 12 12 PJTFWv4.26 01/20/2014**Page 639 of 1107**TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 0- 1 1- 2 2- 3 3- 4 4- 5 5- 6 6- 7 7- 8 8- 9 9- 10 10- 11 11- 12

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 1: 0 PPM

------------------------------------------- 91629 28. 32. 36. 49. 23. 28. 35. 35. 40. 23. 26. 25. 91630 12. 34. 32. 31. 28. 34. 0. 30. 45. 32. 30. 36. 91633 37. NA 33. 31. 34. 28. 31. 32. 34. 28. 35. 39. 91637 36. 33. 38. 57. 37. 33. 38. 36. 37. 33. 38. 41. 91639 29. 29. 26. 28. 24. 31. 27. 33. 38. 32. 54. 23. 91644 26. 50. 27. 41. 26. 27. 60. 26. 67. 19. 76. 58. 91645 50. 34. 40. 85. 29. 42. 54. 55. 35. 42. 34. 55. 91648 24. 26. 36. 32. 29. 16. 40. 34. 34. 16. 32. 27. 91653 28. 23. 34. 46. 25. 24. 28. 32. 39. 29. 26. 43. 91660 33. 32. 35. 33. 31. 31. 32. 31. 32. 27. 23. 25. 91670 22. 42. 32. 34. 29. 37. 37. 35. 39. 16. 39. 37. 91672 19. 37. 31. 37. 29. 49. 37. 42. 25. 31. 35. 36.

MEAN 29. 34. 33. 42. 29. 32. 35. 35. 39. 27. 37. 37. S.D. 9.8 7.3 4.2 16.2 4.2 8.6 14.8 7.2 10.1 7.7 14.6 11.3 S.E. 2.8 2.2 1.2 4.7 1.2 2.5 4.3 2.1 2.9 2.2 4.2 3.3 N 12 11 12 12 12 12 12 12 12 12 12 12

NA = NOT APPLICABLE**Page 640 of 1107**TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 12- 13 13- 27 27- 28 28- 29 29- 30 30- 31 31- 32 32- 33 33- 34 34- 35 35- 36 36- 37

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 1: 0 PPM

------------------------------------------- 91629 23. NA NA NA NA NA NA NA NA NA NA NA 91630 25. NA NA NA NA NA NA NA NA NA NA NA 91633 41. NA NA NA NA NA NA NA NA NA NA NA 91637 41. NA NA NA NA NA NA NA NA NA NA NA 91639 37. NA NA NA NA NA NA NA NA NA NA NA 91644 58. NA NA NA NA NA NA NA NA NA NA NA 91645 44. NA NA NA NA NA NA NA NA NA NA NA 91648 29. NA NA NA NA NA NA NA NA NA NA NA 91653 40. NA NA NA NA NA NA NA NA NA NA NA 91660 31. NA NA NA NA NA NA NA NA NA NA NA 91670 34. NA NA NA NA NA NA NA NA NA NA NA 91672 38. NA NA NA NA NA NA NA NA NA NA NA

MEAN 37. NA NA NA NA NA NA NA NA NA NA NA S.D. 9.5 S.E. 2.7 N 12

NA = NOT APPLICABLE**Page 641 of 1107**TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 37- 38 38- 39 39- 40 40- 41 41- 42 42- 43 43- 44 44- 45 45- 46 46- 47 47- 48 48- 49

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 1: 0 PPM

------------------------------------------- 91629 NA NA NA NA NA 91630 NA NA NA NA NA NA 91633 NA NA NA 91637 NA NA 91639 NA NA NA NA NA 91644 NA NA NA 91645 NA NA NA NA NA NA 91648 NA NA NA 91653 NA NA NA NA NA 91660 NA NA NA NA NA 91670 NA NA NA NA NA NA 91672 NA NA NA NA NA NA

MEAN NA NA NA NA NA NA S.D. S.E. N

NA = NOT APPLICABLE**Page 642 of 1107**TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 49- 50 50- 51 51- 52 0- 7 0- 13

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 1: 0 PPM

------------------------------------------- 91629 33. 31. 91630 24. 28. 91633 33. 34. 91637 39. 38. 91639 28. 32. 91644 37. 43. 91645 48. 46. 91648 29. 29. 91653 30. 32. 91660 33. 31. 91670 33. 33. 91672 34. 34.

MEAN 33. 34. S.D. 6.1 5.6 S.E. 1.7 1.6 N 12 12**Page 643 of 1107**TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 0- 1 1- 2 2- 3 3- 4 4- 5 5- 6 6- 7 7- 8 8- 9 9- 10 10- 11 11- 12

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 2: 50 PPM

------------------------------------------- 91632 28. 33. 31. 57. 24. 32. 39. 37. 50. 30. 31. 44. 91640 31. 26. 31. 69. 43. 38. 45. 36. 31. 30. 27. 29. 91642 17. 24. 33. 42. 19. 23. 34. 29. 28. 17. 32. 28. 91647 22. 44. 39. 51. 25. 41. 46. 41. 43. 45. 55. 61. 91651 25. 23. 26. 26. 24. 27. 27. 26. 20. 19. 28. 23. 91659 13. 32. 28. 36. 26. 22. 34. 31. 37. 21. 34. 33. 91661 38. 44. 64. 57. 41. 45. NA 57. 44. 35. 40. 50. 91663 38. 38. 28. 74. 37. 35. 49. 29. 39. 39. 52. 64. 91669 15. 28. 28. 42. 24. 19. 36. 29. 35. 35. 31. 25. 91673 19. 32. 32. 36. 25. 34. 37. 31. 30. 31. 30. 33. 91683 26. 25. 27. 34. 31. 33. 36. 24. 33. 33. 29. 34. 91685 20. 27. 27. 29. 23. 27. 35. 25. 29. 29. 24. 28.

MEAN 24. 31. 33. 46. 29. 31. 38. 33. 35. 30. 34. 38. S.D. 8.1 7.2 10.4 15.4 7.9 7.9 6.3 9.1 8.3 8.1 9.8 13.7 S.E. 2.3 2.1 3.0 4.4 2.3 2.3 1.9 2.6 2.4 2.3 2.8 4.0 N 12 12 12 12 12 12 11 12 12 12 12 12

NA = NOT APPLICABLE**Page 644 of 1107**TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 12- 13 13- 27 27- 28 28- 29 29- 30 30- 31 31- 32 32- 33 33- 34 34- 35 35- 36 36- 37

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 2: 50 PPM

------------------------------------------- 91632 52. NA NA NA NA NA NA NA NA NA NA NA 91640 27. NA NA NA NA NA NA NA NA NA NA NA 91642 27. NA NA NA NA NA NA NA NA NA NA NA 91647 35. NA NA NA NA NA NA NA NA NA NA NA 91651 24. NA NA NA NA NA NA NA NA NA NA NA 91659 31. NA NA NA NA NA NA NA NA NA NA NA 91661 70. NA NA NA NA NA NA NA NA NA NA NA 91663 62. NA NA NA NA NA NA NA NA NA NA NA 91669 32. NA NA NA NA NA NA NA NA NA NA NA 91673 26. NA NA NA NA NA NA NA NA NA NA NA 91683 31. NA NA NA NA NA NA NA NA NA NA NA 91685 30. NA NA NA NA NA NA NA NA NA NA NA

MEAN 37. NA NA NA NA NA NA NA NA NA NA NA S.D. 15.2 S.E. 4.4 N 12

NA = NOT APPLICABLE**Page 645 of 1107**TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 37- 38 38- 39 39- 40 40- 41 41- 42 42- 43 43- 44 44- 45 45- 46 46- 47 47- 48 48- 49

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 2: 50 PPM

------------------------------------------- 91632 NA NA NA NA NA NA NA 91640 NA NA NA NA NA NA NA 91642 NA NA NA NA 91647 NA NA NA NA NA NA 91651 NA NA NA NA NA 91659 NA NA NA NA 91661 NA NA NA 91663 NA NA NA NA NA 91669 NA NA NA 91673 NA NA NA NA NA NA 91683 NA NA NA NA NA NA NA 91685 NA NA NA

MEAN NA NA NA NA NA NA NA S.D. S.E. N

NA = NOT APPLICABLE**Page 646 of 1107**TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 49- 50 50- 51 51- 52 0- 7 0- 13

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 2: 50 PPM

------------------------------------------- 91632 35. 38. 91640 40. 36. 91642 28. 27. 91647 38. 42. 91651 25. 24. 91659 27. 29. 91661 48. 49. 91663 43. 45. 91669 28. 29. 91673 31. 30. 91683 30. 30. 91685 27. 27.

MEAN 33. 34. S.D. 7.4 7.8 S.E. 2.1 2.2 N 12 12**Page 647 of 1107**TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 0- 1 1- 2 2- 3 3- 4 4- 5 5- 6 6- 7 7- 8 8- 9 9- 10 10- 11 11- 12

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 3: 100 PPM

------------------------------------------- 91620 15. 36. 33. 65. 29. 24. 40. 64. 35. 29. 26. 41. 91628 33. 26. 42. 73. 40. 22. 44. 65. 32. 35. 33. 49. 91631 25. 39. 48. 79. 28. 30. 46. 52. 31. 25. 25. 49. 91636 36. 37. 36. 64. 46. 47. 41. 57. 47. 48. 42. 58. 91649 19. 27. 15. 31. 27. 28. 32. 22. 30. 27. 29. 32. 91650 26. 37. 30. 34. 36. 38. 48. 27. 30. 35. 41. 34. 91656 15. 35. 38. 64. 33. 28. 42. 40. 67. 34. 32. 48. 91671 37. 38. 46. 60. 26. 27. 42. 39. 65. 41. 39. 30. 91675 25. 29. 25. 41. 20. 31. 30. 26. 33. 49. 28. 29. 91677 28. 29. 33. 26. 19. 31. 34. 27. 35. 44. 33. 35. 91679 34. 32. 34. 36. 38. 41. 40. 31. 35. 41. 42. 41. 91684 33. 18. 37. 31. 29. 34. 42. 35. 35. 32. 25. 38.

MEAN 27. 32. 35. 50. 31. 32. 40. 40. 40. 37. 33. 40. S.D. 7.6 6.2 9.0 18.8 7.9 7.2 5.5 15.3 13.2 8.0 6.5 9.0 S.E. 2.2 1.8 2.6 5.4 2.3 2.1 1.6 4.4 3.8 2.3 1.9 2.6 N 12 12 12 12 12 12 12 12 12 12 12 12**Page 648 of 1107**TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 12- 13 13- 27 27- 28 28- 29 29- 30 30- 31 31- 32 32- 33 33- 34 34- 35 35- 36 36- 37

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 3: 100 PPM

------------------------------------------- 91620 43. NA NA NA NA NA NA NA NA NA NA NA 91628 52. NA NA NA NA NA NA NA NA NA NA NA 91631 67. NA NA NA NA NA NA NA NA NA NA NA 91636 55. NA NA NA NA NA NA NA NA NA NA NA 91649 33. NA NA NA NA NA NA NA NA NA NA NA 91650 34. NA NA NA NA NA NA NA NA NA NA NA 91656 85. NA NA NA NA NA NA NA NA NA NA NA 91671 53. NA NA NA NA NA NA NA NA NA NA NA 91675 31. NA NA NA NA NA NA NA NA NA NA NA 91677 33. NA NA NA NA NA NA NA NA NA NA NA 91679 39. NA NA NA NA NA NA NA NA NA NA NA 91684 43. NA NA NA NA NA NA NA NA NA NA NA

MEAN 47. NA NA NA NA NA NA NA NA NA NA NA S.D. 16.3 S.E. 4.7 N 12

NA = NOT APPLICABLE**Page 649 of 1107**TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 11 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 37- 38 38- 39 39- 40 40- 41 41- 42 42- 43 43- 44 44- 45 45- 46 46- 47 47- 48 48- 49

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 3: 100 PPM

------------------------------------------- 91620 NA NA NA NA NA NA 91628 NA NA NA NA 91631 NA NA NA NA 91636 NA NA NA NA NA 91649 NA NA NA 91650 NA NA NA 91656 NA NA NA NA NA NA NA NA 91671 NA NA NA NA NA NA NA NA 91675 NA NA NA NA 91677 NA NA NA NA NA 91679 NA NA NA 91684 NA NA NA NA

MEAN NA NA NA NA NA NA NA NA S.D. S.E. N

NA = NOT APPLICABLE**Page 650 of 1107**TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 12 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 49- 50 50- 51 51- 52 0- 7 0- 13

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 3: 100 PPM

------------------------------------------- 91620 35. 37. 91628 40. 42. 91631 42. 42. 91636 44. 47. 91649 26. 27. 91650 35. 35. 91656 37. 43. 91671 39. 42. 91675 29. 31. 91677 28. 31. 91679 36. 37. 91684 32. 33.

MEAN 35. 37. S.D. 5.7 6.1 S.E. 1.6 1.7 N 12 12**Page 651 of 1107**TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 13 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 0- 1 1- 2 2- 3 3- 4 4- 5 5- 6 6- 7 7- 8 8- 9 9- 10 10- 11 11- 12

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 4: 175 PPM

------------------------------------------- 91622 29. 46. 63. 83. 40. 42. 55. 47. 26. 34. 37. 37. 91623 21. 32. 39. 61. 31. 32. 41. 34. 45. 48. 40. 37. 91626 28. 33. 46. 54. 45. 37. 33. 42. 54. 43. 36. 32. 91643 28. 33. 29. 40. 38. 37. 34. 27. 34. 30. 35. 32. 91654 29. 38. 36. 41. 34. 42. 41. 42. 45. 40. 45. 39. 91657 25. 47. 49. 57. 41. 43. 45. 37. 44. 45. 44. 50. 91662 17. 31. 32. 53. 28. 39. 37. 30. 34. 33. 34. 32. 91666 31. 30. 22. 40. NA 35. 31. 24. 33. 31. 31. 36. 91676 22. 25. 26. 27. 18. 29. 29. 25. 38. 25. 25. 28. 91678 32. 32. 42. 35. 34. 10. 20. 25. 50. 49. 36. 37. 91681 50. 31. 45. 41. 34. 38. 31. 24. 36. 37. 36. 38. 91682 22. 48. 52. 54. 39. 40. 46. 45. 49. 42. 39. 46.

MEAN 28. 35. 40. 49. 35. 35. 37. 33. 41. 38. 37. 37. S.D. 8.3 7.4 12.1 14.8 7.2 8.7 9.2 8.6 8.4 7.6 5.4 6.2 S.E. 2.4 2.1 3.5 4.3 2.2 2.5 2.7 2.5 2.4 2.2 1.6 1.8 N 12 12 12 12 11 12 12 12 12 12 12 12

NA = NOT APPLICABLE**Page 652 of 1107**TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 14 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 12- 13 13- 27 27- 28 28- 29 29- 30 30- 31 31- 32 32- 33 33- 34 34- 35 35- 36 36- 37

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 4: 175 PPM

------------------------------------------- 91622 34. NA NA NA NA NA NA NA NA NA NA NA 91623 39. NA 46. 37. 48. 32. 33. 38. 32. 34. 30. 32. 91626 41. NA NA NA NA NA NA NA NA NA NA NA 91643 36. NA NA NA NA NA NA NA NA NA NA NA 91654 49. NA NA NA NA NA NA NA NA NA NA NA 91657 47. NA NA NA NA NA NA NA NA NA NA NA 91662 44. NA NA NA NA NA NA NA NA NA NA NA 91666 35. NA NA NA NA NA NA NA NA NA NA NA 91676 33. NA NA NA NA NA NA NA NA NA NA NA 91678 38. NA NA NA NA NA NA NA NA NA NA NA 91681 46. NA NA NA NA NA NA NA NA NA NA NA 91682 53. NA NA NA NA NA NA NA NA NA NA NA

MEAN 41. NA 46. 37. 48. 32. 33. 38. 32. 34. 30. 32. S.D. 6.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 S.E. 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 N 12 1 1 1 1 1 1 1 1 1 1

NA = NOT APPLICABLE**Page 653 of 1107**TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 15 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 37- 38 38- 39 39- 40 40- 41 41- 42 42- 43 43- 44 44- 45 45- 46 46- 47 47- 48 48- 49

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 4: 175 PPM

------------------------------------------- 91622 NA NA NA 91623 34. 30. 39. 32. 37. 33. 31. 33. 33. 33. 29. 31. 91626 NA NA NA NA NA NA 91643 NA NA NA NA NA NA NA NA NA 91654 NA NA NA NA NA NA NA 91657 NA NA NA NA NA NA NA NA NA NA NA NA 91662 NA NA NA NA NA NA 91666 NA NA NA NA 91676 NA NA NA NA NA 91678 NA NA NA NA 91681 NA NA NA NA NA NA NA NA NA NA NA NA 91682 NA NA NA NA NA NA

MEAN 34. 30. 39. 32. 37. 33. 31. 33. 33. 33. 29. 31. S.D. 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 S.E. 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 N 1 1 1 1 1 1 1 1 1 1 1 1

NA = NOT APPLICABLE**Page 654 of 1107**TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 16 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 49- 50 50- 51 51- 52 0- 7 0- 13

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 4: 175 PPM

------------------------------------------- 91622 51. 44. 91623 33. 33. 29. 37. 38. 91626 39. 40. 91643 34. 33. 91654 37. 40. 91657 NA NA 44. 44. 91662 34. 34. 91666 32. 32. 91676 25. 27. 91678 29. 34. 91681 NA 39. 37. 91682 43. 44.

MEAN 33. 33. 29. 37. 37. S.D. 0.0 0.0 0.0 7.0 5.5 S.E. 0.0 0.0 0.0 2.0 1.6 N 1 1 1 12 12

NA = NOT APPLICABLE**Page 655 of 1107**TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 17 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 0- 1 1- 2 2- 3 3- 4 4- 5 5- 6 6- 7 7- 8 8- 9 9- 10 10- 11 11- 12

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 5: 10000 PPM

------------------------------------------- 91624 27. 26. 30. 30. 30. 32. 37. 39. 50. 31. 33. 33. 91625 29. 29. 28. 39. 31. 31. 29. 32. 49. 33. 31. 27. 91627 28. 35. 37. 42. 29. 38. 39. 29. 35. 38. 36. 36. 91634 27. 33. 32. 36. 32. 33. 32. 27. 41. 30. 27. 29. 91635 11. 27. 23. 27. 24. 25. 31. 25. 29. 27. 29. 26. 91638 19. 29. 29. 33. 33. 28. 33. 26. 26. 25. 29. 32. 91652 31. 39. 45. 61. 29. 37. 45. 44. 30. 30. 28. 38. 91655 23. 30. 27. 38. 25. 28. 31. 33. 38. 27. 22. 27. 91658 27. 35. 38. 45. 37. 38. 38. 40. 40. 33. 23. 33. 91667 20. 31. 27. 24. 28. 29. 31. 26. 38. 27. 30. 30. 91668 19. 27. 28. 27. 26. 24. 29. 32. 34. 23. 21. 34. 91680 17. 31. 30. 30. 32. 26. 35. 27. 26. 24. 26. 26.

MEAN 23. 31. 31. 36. 30. 31. 34. 32. 36. 29. 28. 31. S.D. 6.1 3.9 5.9 10.1 3.5 4.9 4.6 6.4 8.0 4.5 4.5 4.1 S.E. 1.8 1.1 1.7 2.9 1.0 1.4 1.3 1.8 2.3 1.3 1.3 1.2 N 12 12 12 12 12 12 12 12 12 12 12 12**Page 656 of 1107**TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 18 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 12- 13 13- 27 27- 28 28- 29 29- 30 30- 31 31- 32 32- 33 33- 34 34- 35 35- 36 36- 37

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 5: 10000 PPM

------------------------------------------- 91624 48. NA NA NA NA NA NA NA NA NA NA NA 91625 53. NA NA NA NA NA NA NA NA NA NA NA 91627 40. NA NA NA NA NA NA NA NA NA NA NA 91634 48. NA NA NA NA NA NA NA NA NA NA NA 91635 33. NA NA NA NA NA NA NA NA NA NA NA 91638 32. NA NA NA NA NA NA NA NA NA NA NA 91652 47. NA NA NA NA NA NA NA NA NA NA NA 91655 37. NA NA NA NA NA NA NA NA NA NA NA 91658 34. NA NA NA NA NA NA NA NA NA NA NA 91667 43. NA NA NA NA NA NA NA NA NA NA NA 91668 40. NA NA NA NA NA NA NA NA NA NA NA 91680 32. NA NA NA NA NA NA NA NA NA NA NA

MEAN 40. NA NA NA NA NA NA NA NA NA NA NA S.D. 7.2 S.E. 2.1 N 12

NA = NOT APPLICABLE**Page 657 of 1107**TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 19 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 37- 38 38- 39 39- 40 40- 41 41- 42 42- 43 43- 44 44- 45 45- 46 46- 47 47- 48 48- 49

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 5: 10000 PPM

------------------------------------------- 91624 NA NA NA NA NA 91625 NA NA NA NA NA NA 91627 NA NA NA 91634 NA NA NA NA NA NA 91635 NA NA NA 91638 NA NA NA NA NA 91652 NA NA NA 91655 NA NA NA 91658 NA NA NA NA 91667 NA NA NA NA 91668 NA NA NA NA 91680 NA NA NA

MEAN NA NA NA NA NA NA S.D. S.E. N

NA = NOT APPLICABLE**Page 658 of 1107**TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 20 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 49- 50 50- 51 51- 52 0- 7 0- 13

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 5: 10000 PPM

------------------------------------------- 91624 30. 34. 91625 31. 34. 91627 36. 36. 91634 32. 33. 91635 24. 26. 91638 29. 29. 91652 41. 39. 91655 29. 30. 91658 37. 35. 91667 27. 30. 91668 26. 28. 91680 29. 28.

MEAN 31. 32. S.D. 4.8 3.9 S.E. 1.4 1.1 N 12 12 PJTFWv4.26 01/16/2014**Page 659 of 1107**TABLE A28 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 0- 7 7- 13 13- 27 27- 35 35- 42 42- 49

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 1: 0 PPM

------------------------------------------- 91629 136. 119. NA NA NA 91630 96. 126. NA NA NA 91633 117. 120. NA NA 91637 158. 145. NA NA 91639 102. 128. NA NA NA 91644 151. 198. NA NA 91645 177. 157. NA NA NA 91648 111. 105. NA NA 91653 118. 131. NA NA NA 91660 125. 99. NA NA NA 91670 127. 123. NA NA NA 91672 127. 120. NA NA NA

MEAN 129. 131. NA NA NA S.D. 23.5 26.3 S.E. 6.8 7.6 N 12 12

NA = NOT APPLICABLE**Page 660 of 1107**TABLE A28 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 0- 7 7- 13 13- 27 27- 35 35- 42 42- 49

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 2: 50 PPM

------------------------------------------- 91632 135. 147. NA NA NA 91640 148. 106. NA NA NA 91642 105. 97. NA NA 91647 162. 192. NA NA NA 91651 96. 84. NA NA NA 91659 102. 108. NA NA 91661 194. 187. NA NA 91663 183. 183. NA NA NA 91669 108. 113. NA NA 91673 116. 111. NA NA NA 91683 124. 121. NA NA NA 91685 111. 110. NA NA

MEAN 132. 130. NA NA NA S.D. 32.9 37.8 S.E. 9.5 10.9 N 12 12

NA = NOT APPLICABLE**Page 661 of 1107**TABLE A28 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 0- 7 7- 13 13- 27 27- 35 35- 42 42- 49

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 3: 100 PPM

------------------------------------------- 91620 135. 141. NA NA NA 91628 170. 182. NA NA 91631 159. 146. NA NA 91636 188. 206. NA NA NA 91649 111. 118. NA NA 91650 138. 123. NA NA 91656 138. 178. NA NA NA 91671 157. 163. NA NA NA 91675 106. 116. NA NA 91677 119. 130. NA NA NA 91679 133. 132. NA NA 91684 129. 131. NA NA

MEAN 140. 147. NA NA NA S.D. 24.3 28.8 S.E. 7.0 8.3 N 12 12

NA = NOT APPLICABLE**Page 662 of 1107**TABLE A28 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 0- 7 7- 13 13- 27 27- 35 35- 42 42- 49

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 4: 175 PPM

------------------------------------------- 91622 207. 142. NA NA 91623 142. 151. NA 119. 105. 100. 91626 147. 146. NA NA NA 91643 128. 115. NA NA NA 91654 153. 168. NA NA NA 91657 161. 156. NA NA NA NA 91662 129. 123. NA NA NA 91666 135. 127. NA NA 91676 109. 116. NA NA NA 91678 105. 128. NA NA 91681 149. 131. NA NA NA NA 91682 156. 157. NA NA NA

MEAN 143. 138. NA 119. 105. 100. S.D. 26.6 17.4 0.0 0.0 0.0 S.E. 7.7 5.0 0.0 0.0 0.0 N 12 12 1 1 1

NA = NOT APPLICABLE**Page 663 of 1107**TABLE A28 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- FEMALES DAY 0- 7 7- 13 13- 27 27- 35 35- 42 42- 49

----------------------------------------------------------------------------------------------------------------------------------- ANIMALS FROM GROUP 5: 10000 PPM

------------------------------------------- 91624 127. 150. NA NA NA 91625 127. 150. NA NA NA 91627 142. 141. NA NA 91634 131. 132. NA NA NA 91635 88. 101. NA NA 91638 116. 107. NA NA NA 91652 166. 140. NA NA 91655 119. 119. NA NA 91658 145. 125. NA NA 91667 99. 114. NA NA 91668 103. 116. NA NA 91680 114. 101. NA NA

MEAN 123. 125. NA NA NA S.D. 21.7 17.7 S.E. 6.3 5.1 N 12 12

NA = NOT APPLICABLE PJTFWv4.26 01/16/2014**Page 664 of 1107**TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 0- 1 1- 2 2- 3 3- 4 4- 5 5- 6 6- 7 7- 8 8- 9

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91629 G 29. 29. 34. 36. 31. 34. 34. 32. 35. 91630 G 27. 40. 37. 36. 35. 38. 37. 34. 40. 91633 G 19. 26. 31. 33. 27. 31. 30. 32. 33. 91637 G 32. 33. 37. 33. 31. 40. 41. 35. 32. 91639 G 23. 25. 33. 36. 44. 35. 42. 45. 43. 91644 G 30. 37. 37. 37. 34. 36. 34. 39. 65. 91645 G 26. 32. 34. 48. 34. 37. 39. 37. 50. 91648 G 26. 29. 31. 28. 33. 33. 37. 35. 33. 91653 G 29. 34. 35. 33. 29. 38. 34. 37. 25. 91660 G 25. 30. 32. 29. 32. 30. 32. 32. 32. 91670 G 28. 34. 38. 42. 36. 35. 43. 40. 40. 91672 G 32. 32. 30. 40. 34. 37. 39. 43. 40.

MEAN 27. 32. 34. 36. 33. 35. 37. 37. 39. S.D. 3.7 4.3 2.7 5.5 4.2 3.0 4.1 4.3 10.4 S.E. 1.1 1.2 0.8 1.6 1.2 0.9 1.2 1.2 3.0 N 12 12 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 665 of 1107**TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 9-10 10-11 11-12 12-13 13-14 14-15 15-16 16-17 17-18

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91629 G NA 35. 35. 39. 38. 36. 41. 39. 42. 91630 G NA 39. 40. 41. 42. 49. 55. 53. 61. 91633 G 33. 42. 37. 41. 40. 39. 50. 45. 42. 91637 G 38. 35. 39. 39. 40. 41. 42. 43. 41. 91639 G 44. 47. 49. 45. 45. 77. 81. 56. 65. 91644 G 76. 50. 78. NA 51. 67. 41. 59. 54. 91645 G 40. 38. 40. 44. 43. 44. 43. 44. 49. 91648 G 34. 36. 45. 41. 41. 46. 44. 48. 46. 91653 G 45. 33. 43. 35. 40. 40. 42. 43. 47. 91660 G 33. 33. 33. 33. 35. 38. 40. 39. 41. 91670 G 41. 40. 40. 45. 45. 43. 52. 47. 50. 91672 G 37. 47. 35. 47. 42. 47. 44. 48. 51.

MEAN 42. 40. 43. 41. 42. 47. 48. 47. 49. S.D. 12.7 5.8 12.0 4.3 4.0 12.4 11.5 6.3 7.8 S.E. 4.0 1.7 3.5 1.3 1.2 3.6 3.3 1.8 2.3 N 10 12 12 11 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN NA = NOT APPLICABLE**Page 666 of 1107**TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 18-19 19-20 20-21 21-22 22-23 23-24 24-25 0- 4 4- 7

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91629 G 38. 38. 37. NA NA NA NA 32. 33. 91630 G 56. 54. 47. NA NA NA NA 35. 37. 91633 G 43. 39. 42. NA NA NA NA 27. 29. 91637 G 42. 37. 50. NA NA NA NA 34. 37. 91639 G 50. 51. 48. 31. NA NA NA 29. 40. 91644 G 55. 37. 46. NA NA NA NA 35. 35. 91645 G 42. 42. 48. NA NA NA NA 35. 37. 91648 G 44. 45. 46. 39. NA NA NA 29. 34. 91653 G 50. 40. 48. NA NA NA NA 33. 34. 91660 G 43. 34. 42. 27. NA NA NA 29. 31. 91670 G 51. 45. 47. NA NA NA NA 36. 38. 91672 G 45. 45. 51. NA NA NA NA 34. 37.

MEAN 47. 42. 46. 32. NA NA NA 32. 35. S.D. 5.7 6.0 3.9 6.1 3.1 3.1 S.E. 1.6 1.7 1.1 3.5 0.9 0.9 N 12 12 12 3 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN NA = NOT APPLICABLE**Page 667 of 1107**TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 7-11 11-14 14-17 17-20 0-20

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91629 G 34. 37. 39. 39. 36. 91630 G 38. 41. 52. 57. 43. 91633 G 35. 39. 45. 41. 36. 91637 G 35. 39. 42. 40. 38. 91639 G 45. 46. 71. 55. 47. 91644 G 58. 65. 56. 49. 48. 91645 G 41. 42. 44. 44. 40. 91648 G 35. 42. 46. 45. 38. 91653 G 35. 39. 42. 46. 38. 91660 G 33. 34. 39. 39. 34. 91670 G 40. 43. 47. 49. 42. 91672 G 42. 41. 46. 47. 41.

MEAN 39. 42. 47. 46. 40. S.D. 7.0 7.8 8.9 5.9 4.3 S.E. 2.0 2.2 2.6 1.7 1.3 N 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 668 of 1107**TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 0- 1 1- 2 2- 3 3- 4 4- 5 5- 6 6- 7 7- 8 8- 9

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91632 G 23. 30. 31. 26. 26. 28. 28. 26. 30. 91640 G 28. 29. 30. 30. 29. 37. 39. 33. 35. 91642 G 25. 28. 30. 30. 31. 29. 27. 30. 26. 91647 G 32. 37. 46. 44. 45. 49. 40. 43. 46. 91651 G 27. 30. 32. 28. 30. 28. 31. 30. 24. 91659 G 37. 30. 35. 37. 37. 38. 34. 44. 41. 91661 G 41. 43. 42. 46. 42. 46. 46. 43. 45. 91663 G 34. 40. 40. 37. 44. 39. 39. 40. 43. 91669 G 32. 28. 37. 36. 42. 38. 42. 38. 31. 91673 G 29. 30. 27. 31. 33. 29. 36. 31. 29. 91683 G 34. 41. 40. 40. 36. 36. 34. 38. 40. 91685 G 28. 35. 38. 40. 36. 38. 42. 39. 38.

MEAN 31. 33. 36. 35. 36. 36. 37. 36. 36. S.D. 5.2 5.5 5.8 6.4 6.3 6.9 5.9 6.0 7.6 S.E. 1.5 1.6 1.7 1.9 1.8 2.0 1.7 1.7 2.2 N 12 12 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 669 of 1107**TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 9-10 10-11 11-12 12-13 13-14 14-15 15-16 16-17 17-18

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91632 G 31. 29. 35. 30. 32. 34. 34. 38. 39. 91640 G 35. 38. 44. 42. 47. 46. 47. 54. 51. 91642 G 28. 34. 35. 34. 35. 34. 42. 38. 45. 91647 G 48. 45. 49. 51. 48. 50. 50. 56. 58. 91651 G 29. 34. 34. 37. 33. 36. 34. 39. 41. 91659 G 38. 45. 41. 45. 47. 51. 53. 56. 60. 91661 G 44. 42. 50. 53. 55. 53. 60. 61. 54. 91663 G 46. 45. 45. 41. 43. 43. 44. 54. 46. 91669 G 31. 36. 32. 35. 40. 41. 41. 41. 45. 91673 G 34. 33. 38. 37. 39. 42. 47. 51. 54. 91683 G 38. 42. 46. 48. 46. 51. 56. 66. 58. 91685 G 38. 43. 43. 48. 46. 46. 49. 49. 42.

MEAN 37. 39. 41. 42. 43. 44. 46. 50. 49. S.D. 6.6 5.5 6.1 7.3 6.9 6.7 8.0 9.4 7.3 S.E. 1.9 1.6 1.8 2.1 2.0 1.9 2.3 2.7 2.1 N 12 12 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 670 of 1107**TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 18-19 19-20 20-21 21-22 22-23 23-24 24-25 0- 4 4- 7

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91632 G 40. 35. 35. NA NA NA NA 28. 27. 91640 G 46. 51. 45. NA NA NA NA 29. 35. 91642 G 41. 36. 43. 33. NA NA NA 28. 29. 91647 G 53. 49. 45. 39. NA NA NA 40. 45. 91651 G 38. 37. 38. 37. NA NA NA 29. 30. 91659 G 52. 53. 55. 52. NA NA NA 35. 36. 91661 G 56. 53. 56. NA NA NA NA 43. 45. 91663 G 47. 44. 46. 35. NA NA NA 38. 41. 91669 G 45. 36. 40. 19. NA NA NA 33. 41. 91673 G 49. 48. 44. 34. NA NA NA 29. 33. 91683 G 60. 55. 48. NA NA NA NA 39. 35. 91685 G 40. 41. 37. 30. NA NA NA 35. 39.

MEAN 47. 45. 44. 35. NA NA NA 34. 36. S.D. 7.0 7.6 6.5 9.2 5.3 6.0 S.E. 2.0 2.2 1.9 3.3 1.5 1.7 N 12 12 12 8 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN NA = NOT APPLICABLE**Page 671 of 1107**TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 7-11 11-14 14-17 17-20 0-20

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91632 G 29. 32. 35. 38. 31. 91640 G 35. 44. 49. 49. 40. 91642 G 30. 35. 38. 41. 33. 91647 G 46. 49. 52. 53. 47. 91651 G 29. 35. 36. 39. 33. 91659 G 42. 44. 53. 55. 44. 91661 G 44. 53. 58. 54. 49. 91663 G 44. 43. 47. 46. 43. 91669 G 34. 36. 41. 42. 37. 91673 G 32. 38. 47. 50. 37. 91683 G 40. 47. 58. 58. 45. 91685 G 40. 46. 48. 41. 41.

MEAN 37. 42. 47. 47. 40. S.D. 6.3 6.5 7.9 6.9 5.9 S.E. 1.8 1.9 2.3 2.0 1.7 N 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 672 of 1107**TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 0- 1 1- 2 2- 3 3- 4 4- 5 5- 6 6- 7 7- 8 8- 9

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91620 G 33. 28. 36. 33. 37. 38. 41. 37. 32. 91628 G 33. 37. 36. 38. 39. 36. 37. 38. 36. 91631 G 29. 35. 36. 41. 37. 49. 44. 42. 42. 91636 G 45. 56. 62. 63. 69. 58. 54. 58. 52. 91649 G 24. 29. 34. 30. 39. 34. 31. 33. 32. 91650 G 28. 35. 41. 40. 44. 47. 50. 45. 57. 91656 G 29. 39. 40. 34. 37. 39. 39. 39. 36. 91671 G 31. 38. 42. 33. 39. 41. 41. 47. 40. 91675 G 30. 31. 40. 34. 40. 40. 43. 35. 40. 91677 G 30. 26. 35. 33. 43. 41. 41. 45. 30. 91679 G 42. 48. 50. 53. 48. 49. 57. 56. 45. 91684 G 22. 30. 42. 40. 41. 46. 39. 40. 41.

MEAN 31. 36. 41. 39. 43. 43. 43. 43. 40. S.D. 6.6 8.7 7.9 9.6 8.9 6.8 7.3 7.8 8.1 S.E. 1.9 2.5 2.3 2.8 2.6 2.0 2.1 2.3 2.3 N 12 12 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 673 of 1107**TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 9-10 10-11 11-12 12-13 13-14 14-15 15-16 16-17 17-18

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91620 G 39. 40. 44. 37. 44. 47. 47. 49. 51. 91628 G 39. 39. 39. 42. 43. 46. 47. 47. 51. 91631 G 46. 49. 52. 53. 53. 57. 53. 52. 53. 91636 G 58. 54. 52. 58. 57. 57. 59. 63. 55. 91649 G 32. 33. 41. 38. 38. 37. 44. 45. 48. 91650 G 51. 50. 53. 54. 56. 58. 62. 65. 60. 91656 G 42. 44. 45. 42. 45. 45. 47. 47. 45. 91671 G 41. 42. 49. 52. 55. 56. 55. 61. 59. 91675 G 38. 44. 42. 43. 50. 53. 57. 55. 50. 91677 G 39. 41. 47. 49. 48. 54. 51. 57. 56. 91679 G 54. 54. 55. 60. 58. 59. 60. 65. 61. 91684 G 39. 44. 45. 54. 47. 53. 55. 46. 48.

MEAN 43. 45. 47. 49. 50. 52. 53. 54. 53. S.D. 7.6 6.3 5.2 7.8 6.4 6.7 5.9 7.7 5.2 S.E. 2.2 1.8 1.5 2.3 1.8 1.9 1.7 2.2 1.5 N 12 12 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 674 of 1107**TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 11 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 18-19 19-20 20-21 21-22 22-23 23-24 24-25 0- 4 4- 7

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91620 G 44. 45. 43. 44. NA NA NA 33. 39. 91628 G 49. 42. 44. 30. NA NA NA 36. 37. 91631 G 49. 49. 53. NA NA NA NA 35. 43. 91636 G 55. 51. 46. 29. NA NA NA 57. 60. 91649 G 45. 42. 40. 38. NA NA NA 29. 35. 91650 G 60. 57. 48. 51. NA NA NA 36. 47. 91656 G 47. 43. 43. 35. NA NA NA 36. 38. 91671 G 61. 53. 52. 44. 7. NA NA 36. 40. 91675 G 50. 46. 45. 37. NA NA NA 34. 41. 91677 G 53. 51. 45. 40. 31. NA NA 31. 42. 91679 G 60. 50. 56. 60. NA NA NA 48. 51. 91684 G 43. 44. 36. 24. NA NA NA 34. 42.

MEAN 51. 48. 46. 39. 19. NA NA 37. 43. S.D. 6.4 4.8 5.6 10.3 17.0 7.8 6.9 S.E. 1.9 1.4 1.6 3.1 12.0 2.2 2.0 N 12 12 12 11 2 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN NA = NOT APPLICABLE**Page 675 of 1107**TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 12 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 7-11 11-14 14-17 17-20 0-20

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91620 G 37. 42. 48. 47. 40. 91628 G 38. 41. 47. 47. 41. 91631 G 45. 53. 54. 50. 46. 91636 G 56. 56. 60. 54. 57. 91649 G 33. 39. 42. 45. 36. 91650 G 51. 54. 62. 59. 51. 91656 G 40. 44. 46. 45. 41. 91671 G 43. 52. 57. 58. 47. 91675 G 39. 45. 55. 49. 43. 91677 G 39. 48. 54. 53. 44. 91679 G 52. 58. 61. 57. 54. 91684 G 41. 49. 51. 45. 43.

MEAN 43. 48. 53. 51. 45. S.D. 6.9 6.3 6.4 5.3 6.1 S.E. 2.0 1.8 1.8 1.5 1.8 N 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 676 of 1107**TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 13 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 0- 1 1- 2 2- 3 3- 4 4- 5 5- 6 6- 7 7- 8 8- 9

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 4: 175 PPM

--------------------------------------- 91622 G 30. 39. 37. 41. 39. 38. 37. 34. 33. 91626 G 35. 37. 45. 48. 43. 43. 43. 39. 44. 91643 G 32. 33. 33. 31. 38. 38. 38. 37. 40. 91654 G 37. 45. 45. 51. 51. 48. 52. 52. 48. 91657 G 25. 41. 40. 41. 48. 46. 47. 47. 42. 91662 G 22. 37. 34. 43. 43. 41. 42. 43. 37. 91666 G 24. 29. 32. 32. 32. 36. 36. 33. 38. 91676 G 24. 31. 31. 34. 36. 40. 35. 32. 37. 91678 G 29. 45. 39. 48. 44. 45. 52. 47. 57. 91681 G 36. 40. 50. 49. 50. 45. 51. 47. 46. 91682 G 41. 43. 45. 47. 57. 46. 53. 59. 53.

MEAN 30. 38. 39. 42. 44. 42. 44. 43. 43. S.D. 6.3 5.4 6.4 7.2 7.3 4.0 7.1 8.6 7.3 S.E. 1.9 1.6 1.9 2.2 2.2 1.2 2.1 2.6 2.2 N 11 11 11 11 11 11 11 11 11

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 677 of 1107**TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 14 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 9-10 10-11 11-12 12-13 13-14 14-15 15-16 16-17 17-18

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 4: 175 PPM

--------------------------------------- 91622 G 36. 43. 50. 53. 52. 49. 57. 56. 46. 91626 G 43. 46. 44. 52. 54. 53. 60. 59. 61. 91643 G 41. 43. 43. 47. 48. 47. 50. 58. 53. 91654 G 52. 56. 52. 59. 54. 62. 52. 61. 61. 91657 G 47. 53. 53. 48. 58. 55. 57. 85. 59. 91662 G 47. 49. 48. 47. 56. 55. 60. 66. 65. 91666 G 38. 41. 41. 43. 46. 47. 53. 54. 50. 91676 G 34. 41. 42. 47. 41. 43. 48. 45. 53. 91678 G 60. 62. 56. 58. 70. 59. 65. 62. 77. 91681 G 54. 58. 56. 60. 62. 57. 60. 69. 62. 91682 G 56. 61. 62. 58. 69. 79. 70. 79. 78.

MEAN 46. 50. 50. 52. 55. 55. 57. 63. 60. S.D. 8.6 8.1 6.8 6.0 9.0 9.8 6.5 11.3 10.2 S.E. 2.6 2.4 2.0 1.8 2.7 2.9 2.0 3.4 3.1 N 11 11 11 11 11 11 11 11 11

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 678 of 1107**TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 15 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 18-19 19-20 20-21 21-22 22-23 23-24 24-25 0- 4 4- 7

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 4: 175 PPM

--------------------------------------- 91622 G 51. 47. 47. 52. NA NA NA 37. 38. 91626 G 60. 56. 51. 49. NA NA NA 41. 43. 91643 G 57. 49. 53. 49. NA NA NA 32. 38. 91654 G 58. 51. 54. 45. 46. NA NA 45. 50. 91657 G 71. 63. 51. 59. NA NA NA 37. 47. 91662 G 68. 56. 52. 42. NA NA NA 34. 42. 91666 G 49. 44. 42. 41. NA NA NA 29. 35. 91676 G 43. 40. 45. 40. NA NA NA 30. 37. 91678 G 65. 57. 70. 60. NA NA NA 40. 47. 91681 G 59. 56. 47. 48. 3. NA NA 44. 49. 91682 G 80. 66. 65. 55. 49. NA NA 44. 52.

MEAN 60. 53. 52. 49. 33. NA NA 38. 43. S.D. 10.6 7.9 8.3 6.9 25.7 5.8 5.9 S.E. 3.2 2.4 2.5 2.1 14.9 1.7 1.8 N 11 11 11 11 3 11 11

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN NA = NOT APPLICABLE**Page 679 of 1107**TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 16 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 7-11 11-14 14-17 17-20 0-20

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 4: 175 PPM

--------------------------------------- 91622 G 37. 52. 54. 48. 43. 91626 G 43. 50. 57. 59. 48. 91643 G 40. 46. 52. 53. 43. 91654 G 52. 55. 58. 57. 52. 91657 G 47. 53. 66. 64. 51. 91662 G 44. 50. 60. 63. 48. 91666 G 38. 43. 51. 48. 40. 91676 G 36. 43. 45. 45. 39. 91678 G 57. 61. 62. 66. 55. 91681 G 51. 59. 62. 59. 53. 91682 G 57. 63. 76. 75. 60.

MEAN 46. 52. 58. 58. 48. S.D. 7.7 6.8 8.3 9.0 6.6 S.E. 2.3 2.1 2.5 2.7 2.0 N 11 11 11 11 11

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 680 of 1107**TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 17 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 0- 1 1- 2 2- 3 3- 4 4- 5 5- 6 6- 7 7- 8 8- 9

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91624 G 31. 33. 37. 37. 44. 40. 38. 42. 39. 91625 G 29. 34. 33. 33. 38. 33. 34. 33. 31. 91627 G NA 38. 45. 40. 38. 38. 44. NA 42. 91634 G 28. 30. 31. 30. 30. 34. 33. 30. 35. 91635 G 21. 32. 30. 33. 34. 36. 34. 30. 32. 91638 G 30. 30. 31. 29. 32. 32. 29. 33. 33. 91652 G 29. 32. 38. 32. 32. 34. 34. 37. 35. 91655 G 23. 28. 31. 28. 31. 29. 32. 32. 29. 91658 G 25. 31. 35. 38. 37. 36. 32. 35. 32. 91667 G 29. 34. 36. 36. 41. 43. 34. 32. 37. 91668 G 27. 34. 29. 32. 35. 39. 35. 35. 33. 91680 G 27. 23. 34. 30. 28. 26. 31. 25. 28.

MEAN 27. 32. 34. 33. 35. 35. 34. 33. 34. S.D. 3.1 3.7 4.5 3.8 4.7 4.7 3.8 4.3 4.0 S.E. 0.9 1.1 1.3 1.1 1.4 1.4 1.1 1.3 1.2 N 11 12 12 12 12 12 12 11 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN NA = NOT APPLICABLE**Page 681 of 1107**TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 18 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 9-10 10-11 11-12 12-13 13-14 14-15 15-16 16-17 17-18

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91624 G 38. 44. 49. 41. 47. 47. 50. 52. 51. 91625 G 37. 37. 35. 40. 39. 42. 37. 46. 42. 91627 G 48. 39. 53. 52. 43. 56. 58. 56. 51. 91634 G 35. 37. 38. 39. 44. 40. 44. 51. 49. 91635 G 33. 35. 38. 40. 44. 38. 40. 41. 40. 91638 G 32. NA 35. 34. 38. 37. 39. 45. 45. 91652 G 36. 39. 41. 44. 45. 45. 49. 54. 49. 91655 G 36. 35. 44. 45. 50. 50. 50. 54. 50. 91658 G 33. 39. 37. 43. 42. 39. 42. 42. 48. 91667 G 33. 37. 37. 37. 37. 43. 43. 48. 47. 91668 G 32. 39. 37. 43. 36. 45. 41. 47. 48. 91680 G 31. 37. 33. 41. 43. 43. 49. 46. 47.

MEAN 35. 38. 40. 42. 42. 44. 45. 49. 47. S.D. 4.6 2.5 6.0 4.5 4.2 5.4 6.1 4.9 3.4 S.E. 1.3 0.8 1.7 1.3 1.2 1.6 1.8 1.4 1.0 N 12 11 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN NA = NOT APPLICABLE**Page 682 of 1107**TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 19 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 18-19 19-20 20-21 21-22 22-23 23-24 24-25 0- 4 4- 7

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91624 G 44. 47. 42. 36. NA NA NA 35. 41. 91625 G 45. 41. 37. 23. NA NA NA 32. 35. 91627 G 56. 50. 52. 44. NA NA NA 41. 40. 91634 G 49. 45. 39. 39. NA NA NA 30. 32. 91635 G 45. 39. 36. 32. NA NA NA 29. 35. 91638 G 43. 41. 42. 27. NA NA NA 30. 31. 91652 G 52. 50. 43. 47. NA NA NA 33. 33. 91655 G 54. 45. 45. 34. NA NA NA 28. 31. 91658 G 34. 40. 43. NA NA NA NA 32. 35. 91667 G 38. 36. 43. NA NA NA NA 34. 39. 91668 G 43. 43. 48. 39. NA NA NA 31. 36. 91680 G 43. 44. 32. NA NA NA NA 29. 28.

MEAN 46. 43. 42. 36. NA NA NA 32. 35. S.D. 6.4 4.3 5.4 7.7 3.5 3.9 S.E. 1.8 1.2 1.6 2.6 1.0 1.1 N 12 12 12 9 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN NA = NOT APPLICABLE**Page 683 of 1107**TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 20 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 7-11 11-14 14-17 17-20 0-20

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91624 G 41. 46. 50. 47. 43. 91625 G 35. 38. 42. 43. 37. 91627 G 43. 49. 57. 52. 47. 91634 G 34. 40. 45. 48. 38. 91635 G 33. 41. 40. 41. 36. 91638 G 33. 36. 40. 43. 35. 91652 G 37. 43. 49. 50. 40. 91655 G 33. 46. 51. 50. 39. 91658 G 35. 41. 41. 41. 37. 91667 G 35. 37. 45. 40. 38. 91668 G 35. 39. 44. 45. 38. 91680 G 30. 39. 46. 45. 35.

MEAN 35. 41. 46. 45. 39. S.D. 3.6 4.0 5.1 4.0 3.4 S.E. 1.0 1.2 1.5 1.2 1.0 N 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN PGFWv4.11 01/16/2014**Page 684 of 1107**TABLE A30 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 0- 4 4- 7 7-11 11-14 14-17 17-20 0-20

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91629 G 122. 119. 117. 120. 118. 106. 117. 91630 G 127. 124. 120. 123. 144. 142. 129. 91633 G 90. 91. 104. 108. 117. 96. 101. 91637 G 124. 128. 116. 121. 122. 107. 119. 91639 G 98. 128. 136. 131. 189. 136. 136. 91644 G 129. 119. 188. 198. 157. 124. 147. 91645 G 115. 115. 123. 120. 118. 107. 114. 91648 G 98. 105. 101. 114. 116. 102. 105. 91653 G 117. 113. 111. 116. 116. 116. 114. 91660 G 96. 97. 99. 97. 104. 95. 97. 91670 G 121. 121. 121. 124. 127. 120. 121. 91672 G 106. 109. 117. 108. 114. 104. 108.

MEAN 112. 114. 121. 123. 129. 113. 117. S.D. 13.6 11.7 23.4 25.2 23.8 15.0 14.5 S.E. 3.9 3.4 6.8 7.3 6.9 4.3 4.2 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 685 of 1107**TABLE A30 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 0- 4 4- 7 7-11 11-14 14-17 17-20 0-20

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91632 G 93. 86. 89. 93. 95. 94. 90. 91640 G 96. 109. 105. 125. 131. 120. 114. 91642 G 95. 92. 91. 100. 101. 98. 94. 91647 G 153. 161. 158. 158. 158. 146. 153. 91651 G 100. 98. 90. 105. 101. 99. 98. 91659 G 113. 109. 120. 120. 135. 125. 120. 91661 G 149. 148. 139. 159. 160. 133. 145. 91663 G 130. 130. 132. 124. 127. 111. 124. 91669 G 115. 133. 104. 105. 113. 103. 109. 91673 G 100. 107. 99. 112. 130. 122. 108. 91683 G 139. 116. 125. 140. 165. 152. 137. 91685 G 132. 136. 132. 145. 142. 111. 131.

MEAN 118. 119. 115. 124. 130. 118. 119. S.D. 21.9 23.0 22.3 22.4 23.9 18.8 20.2 S.E. 6.3 6.6 6.4 6.5 6.9 5.4 5.8 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 686 of 1107**TABLE A30 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 0- 4 4- 7 7-11 11-14 14-17 17-20 0-20

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91620 G 108. 120. 108. 117. 126. 112. 112. 91628 G 137. 134. 131. 134. 142. 125. 132. 91631 G 114. 132. 130. 144. 137. 114. 126. 91636 G 216. 208. 186. 177. 178. 145. 182. 91649 G 109. 125. 111. 124. 123. 115. 113. 91650 G 126. 154. 155. 156. 167. 142. 148. 91656 G 113. 117. 119. 125. 123. 109. 115. 91671 G 114. 119. 123. 143. 148. 135. 129. 91675 G 112. 127. 115. 127. 146. 118. 121. 91677 G 109. 138. 124. 148. 158. 148. 137. 91679 G 156. 156. 152. 161. 159. 137. 151. 91684 G 125. 149. 138. 155. 151. 117. 135.

MEAN 128. 140. 133. 143. 147. 126. 133. S.D. 31.1 25.3 22.4 17.9 17.5 14.1 19.9 S.E. 9.0 7.3 6.5 5.2 5.0 4.1 5.7 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 687 of 1107**TABLE A30 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 0- 4 4- 7 7-11 11-14 14-17 17-20 0-20

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 4: 175 PPM

--------------------------------------- 91622 G 139. 134. 125. 166. 162. 129. 137. 91626 G 136. 136. 130. 144. 153. 142. 137. 91643 G 102. 117. 116. 127. 134. 123. 118. 91654 G 156. 164. 164. 166. 163. 143. 155. 91657 G 112. 137. 131. 142. 166. 146. 136. 91662 G 112. 132. 134. 147. 168. 158. 140. 91666 G 112. 129. 133. 143. 160. 136. 134. 91676 G 113. 131. 120. 136. 133. 119. 124. 91678 G 120. 132. 150. 154. 149. 145. 141. 91681 G 148. 158. 157. 175. 173. 146. 155. 91682 G 141. 159. 167. 176. 201. 181. 168.

MEAN 126. 139. 139. 152. 160. 143. 140. S.D. 18.0 14.7 17.7 16.3 18.8 17.1 14.3 S.E. 5.4 4.4 5.3 4.9 5.7 5.1 4.3 N 11 11 11 11 11 11 11

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN**Page 688 of 1107**TABLE A30 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/KG/DAY]

----------------------------------------------------------------------------------------------------------------------------------- PREGNANCY STATUS DAY 0- 4 4- 7 7-11 11-14 14-17 17-20 0-20

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91624 G 125. 136. 131. 142. 144. 121. 131. 91625 G 121. 126. 121. 124. 129. 118. 121. 91627 G 150. 141. 146. 159. 173. 140. 150. 91634 G 109. 108. 109. 122. 129. 124. 117. 91635 G 102. 116. 103. 121. 110. 101. 107. 91638 G 103. 100. 102. 107. 112. 109. 104. 91652 G 116. 106. 110. 120. 130. 120. 115. 91655 G 102. 105. 107. 143. 147. 128. 120. 91658 G 112. 117. 112. 125. 118. 108. 113. 91667 G 115. 126. 108. 109. 122. 98. 111. 91668 G 108. 118. 108. 112. 117. 108. 110. 91680 G 105. 97. 100. 122. 134. 117. 109.

MEAN 114. 116. 113. 126. 130. 116. 117. S.D. 13.6 13.9 13.4 15.3 17.7 11.9 12.6 S.E. 3.9 4.0 3.9 4.4 5.1 3.4 3.6 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN PGFWv4.11 01/16/2014**Page 689 of 1107**TABLE A31 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING LACTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

DAY 0- 1 1- 2 2- 3 3- 4 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91629 NA 29. 52. 59. 47. 91630 34. 40. 55. 68. 54. 91633 NA 29. 47. 47. 41. 91637 NA 43. 55. 60. 53. 91639 NA 40. 56. 60. 52. 91644 NA 62. 88. 99. 83. 91645 38. 58. 67. 84. 70. 91648 NA 43. 65. 53. 54. 91653 38. 49. 58. 73. 60. 91660 NA 53. 65. 63. 60. 91670 54. 53. 98. 131. 94. 91672 41. 59. 65. 58. 61.

MEAN 41. 47. 64. 71. 61. S.D. 7.7 11.0 14.9 23.5 15.1 S.E. 3.4 3.2 4.3 6.8 4.3 N 5 12 12 12 12 NA = NOT APPLICABLE**Page 690 of 1107**TABLE A31 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING LACTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

DAY 0- 1 1- 2 2- 3 3- 4 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91632 NA 34. 44. 49. 42. 91640 NA 47. 54. 62. 54. 91642 NA 42. 52. 47. 47. 91647 NA 36. 46. 57. 46. 91651 39. 42. 60. 56. 53. 91659 NA 44. 51. 68. 54. 91661 39. 55. 65. 52. 57. 91663 NA 37. 52. 55. 48. 91669 NA 39. 69. 63. 57. 91673 NA 32. 47. NA 40. 91683 NA 29. 49. 57. 45. 91685 NA 25. 39. 47. 37.

MEAN 39. 39. 52. 56. 48. S.D. 0.0 8.2 8.7 6.8 6.7 S.E. 0.0 2.4 2.5 2.0 1.9 N 2 12 12 11 12 NA = NOT APPLICABLE**Page 691 of 1107**TABLE A31 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING LACTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

DAY 0- 1 1- 2 2- 3 3- 4 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91620 33. 54. 64. 65. 61. 91628 NA 44. 47. 51. 47. 91631 19. 44. 57. 64. 55. 91636 NA 31. 42. 48. 40. 91649 NA 44. 50. 49. 48. 91650 NA 45. 56. 75. 59. 91656 NA 41. 49. 48. 46. 91671 23. 37. 51. 57. 48. 91675 37. 42. 57. 63. 54. 91677 NA 22. 33. 31. 29. 91679 NA 42. 49. 47. 46. 91684 NA 31. 42. 40. 38.

MEAN 28. 40. 50. 53. 48. S.D. 8.4 8.4 8.3 12.1 9.1 S.E. 4.2 2.4 2.4 3.5 2.6 N 4 12 12 12 12 NA = NOT APPLICABLE**Page 692 of 1107**TABLE A31 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING LACTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

DAY 0- 1 1- 2 2- 3 3- 4 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 4: 175 PPM

--------------------------------------- 91622 NA 36. 47. 42. 42. 91626 NA 51. 60. 75. 62. 91643 NA 37. 51. 46. 45. 91654 NA 13. NA NA NA 91657 NA 23. 40. 36. 33. 91662 46. 34. 38. 41. 38. 91666 18. 37. 41. 43. 40. 91676 32. 46. 39. 49. 45. 91678 34. 51. 66. 84. 67. 91681 35. 51. 57. 81. 63. 91682 NA 15. 30. 35. 27.

MEAN 33. 36. 47. 53. 46. S.D. 10.0 13.9 11.4 19.1 13.5 S.E. 4.5 4.2 3.6 6.0 4.3 N 5 11 10 10 10 NA = NOT APPLICABLE**Page 693 of 1107**TABLE A31 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING LACTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

DAY 0- 1 1- 2 2- 3 3- 4 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91624 NA 39. 46. 50. 45. 91625 36. 48. 65. 60. 58. 91627 NA 41. 53. 48. 47. 91634 NA 45. 64. NA 55. 91635 NA 41. 57. 55. 51. 91638 NA 42. 57. 66. 55. 91652 NA 39. 56. 56. 50. 91655 NA 35. 34. 45. 38. 91658 23. 46. 50. 55. 50. 91667 34. 47. 59. 71. 59. 91668 NA 37. 50. 54. 47. 91680 29. 43. 51. 62. 52.

MEAN 31. 42. 54. 57. 51. S.D. 5.8 4.1 8.4 7.8 5.9 S.E. 2.9 1.2 2.4 2.3 1.7 N 4 12 12 11 12 NA = NOT APPLICABLE PLFWv4.13 01/16/2014**Page 694 of 1107**TABLE A32 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING LACTATION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

DAY 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91629 160. 91630 171. 91633 116. 91637 172. 91639 146. 91644 272. 91645 207. 91648 151. 91653 180. 91660 172. 91670 281. 91672 163.

MEAN 183. S.D. 48.9 S.E. 14.1 N 12**Page 695 of 1107**TABLE A32 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING LACTATION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

DAY 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91632 135. 91640 153. 91642 137. 91647 158. 91651 163. 91659 148. 91661 183. 91663 147. 91669 187. 91673 125. 91683 141. 91685 128.

MEAN 150. S.D. 19.8 S.E. 5.7 N 12**Page 696 of 1107**TABLE A32 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING LACTATION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

DAY 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91620 176. 91628 168. 91631 158. 91636 137. 91649 160. 91650 170. 91656 140. 91671 142. 91675 154. 91677 94. 91679 138. 91684 133.

MEAN 148. S.D. 22.2 S.E. 6.4 N 12**Page 697 of 1107**TABLE A32 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING LACTATION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

DAY 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 4: 175 PPM

--------------------------------------- 91622 143. 91626 177. 91643 127. 91654 NA 91657 93. 91662 115. 91666 142. 91676 143. 91678 173. 91681 197. 91682 81.

MEAN 139. S.D. 36.8 S.E. 11.6 N 10 NA = NOT APPLICABLE**Page 698 of 1107**TABLE A32 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING LACTATION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

DAY 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91624 139. 91625 203. 91627 156. 91634 172. 91635 157. 91638 177. 91652 143. 91655 123. 91658 162. 91667 176. 91668 142. 91680 170.

MEAN 160. S.D. 21.5 S.E. 6.2 N 12 PLFWv4.13 01/16/2014**Page 699 of 1107**TABLE A33 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ESTROUS CYCLE DATA

----------------------------------------------------------------------------------------------------------------------------------- FEMALES FROM GROUP 1: 0 PPM INDIVIDUAL -------------------------------------- MEAN LENGTH FEMALE DETERMINATION 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 OF ESTRUS NUMBER DAY: 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 CYCLE (DAYS)

----------------------------------------------------------------------------------------------------------------------------------- T B

----------------------------------------------------------------------------------------------------------------------------------- 91629 D D P E D D P E D D P E D D D E D D D E D D P E D D D + 4.0 91630 D D D E D D D E D D D E D D D E D D D E D D D E D D P C 4.0 91633 D E D D D D D E D D D P E D D D D D D D P D D D E C 8.0 91637 E D D D E D D D E D D D E D D D E D D D E M D D + 4.0 91639 D E D D D E D D D E D D D P E D D D E D D D E D D D C 4.3 91644 E D D P E D D P E D D D E D D D E D D P E E D D E C 4.5 91645 D D D E D D P E D D D E D D D E D D P E D D P E E D P C 4.3 91648 E D D D E D D D E D D D E D D D E D D P E E D D + 4.5 91653 D D D E D D P E E D D P E D D D D E D D P E E D D P C 5.0 91660 D D D D P E D D D P E D D D D D D D D D D D E D D D C 12.0 91670 D D D E D D P E D D D E D D D E D D P E D D D E D D D C 4.0 91672 D D D E D D D E D D D E D D D E D D D E D D D E - D D C 4.0

MEAN 5.2 S.D. 2.41 S.E. 0.70 N 12

----------------------------------------------------------------------------------------------------------------------------------- ESTROUS STAGE CODE: E = ESTRUS, D = DIESTRUS, M = METESTRUS, P = PROESTRUS T = FIRST DAY OF TREATMENT, B = FIRST DAY OF BREEDING PERIOD C = COPULATORY PLUG OBSERVED, + = SMEARED POSITIVE, - = SMEARED NEGATIVE**Page 700 of 1107**TABLE A33 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ESTROUS CYCLE DATA

----------------------------------------------------------------------------------------------------------------------------------- FEMALES FROM GROUP 2: 50 PPM INDIVIDUAL -------------------------------------- MEAN LENGTH FEMALE DETERMINATION 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 OF ESTRUS NUMBER DAY: 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 CYCLE (DAYS)

----------------------------------------------------------------------------------------------------------------------------------- T B

----------------------------------------------------------------------------------------------------------------------------------- 91632 D E D D D E D D D E E D D D P E D D P E D D D E E D D P C 4.7 91640 D D D E D D D P E D D D P D D D D D E D D D P E D D D P C 5.5 91642 D D D E D D D E D D D E D D D E D D D E E D D D E C 4.5 91647 D D D E D D D E D D D E D D D E D D D E D D D E D D D C 4.0 91651 D D E D D D E D D D E D D D P E D D D E E D D D E C 5.0 91659 D D D E D D D E D D D P D D D E E D D D E D D D E C 4.5 91661 E D D D E D D D E D D D E D D P E D D P E D D P C 4.0 91663 D E D D D E D D D E D D D E D D D E E D D D D D D D C 4.5 91669 D D D E D D P E D D D E D D D P E D D P D D D E C 4.0 91673 D D P E D D D E D D D E D D D E D D P E D D D E D D D + 4.0 91683 E D D D E D D D E D D D E E D D D P E D D D E E D D D E C 5.0 91685 D D E D D D E D D D E D D D P E D D D E E D D P C 5.0

MEAN 4.6 S.D. 0.50 S.E. 0.14 N 12

----------------------------------------------------------------------------------------------------------------------------------- ESTROUS STAGE CODE: E = ESTRUS, D = DIESTRUS, M = METESTRUS, P = PROESTRUS T = FIRST DAY OF TREATMENT, B = FIRST DAY OF BREEDING PERIOD C = COPULATORY PLUG OBSERVED, + = SMEARED POSITIVE**Page 701 of 1107**TABLE A33 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ESTROUS CYCLE DATA

----------------------------------------------------------------------------------------------------------------------------------- FEMALES FROM GROUP 3: 100 PPM INDIVIDUAL -------------------------------------- MEAN LENGTH FEMALE DETERMINATION 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 OF ESTRUS NUMBER DAY: 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 CYCLE (DAYS)

----------------------------------------------------------------------------------------------------------------------------------- T B

----------------------------------------------------------------------------------------------------------------------------------- 91620 D D D E D D D E D D D E D D D E E D D D P E D D D E C 5.0 91628 E D D D E D D D E D D D E D D D E D D D E E D D D C 4.5 91631 D D D E D D D E D D D E D D D E E D D D E E D D D C 5.0 91636 D E D D P E D D D E D D P E D D P E D D P E E D D P + 4.3 91649 D E D D D E D D D E D D D E D D D P E E D D D E + 5.0 91650 D E D D D E D D D E D D D P E D D D P E D D D E + 5.0 91656 D D D E D D D E D D D E D D D E E D D D D D D D D D D D P + 5.0 91671 E D D D P E D D D P E D D D P E E D D D D P E D D D P E C 6.0 91675 D E D D D E D D D E D D D P E D D D E E D D P E C 5.0 91677 D D E D D D E D D P E D D D E E D D D E E D D D E C 5.0 91679 P E D D D E D D D E D D D E E D D P E E D D P E C 5.0 91684 E D D D E D D D E D D D E D D D P D D D D E D D D C 4.5

MEAN 4.9 S.D. 0.42 S.E. 0.12 N 12

----------------------------------------------------------------------------------------------------------------------------------- ESTROUS STAGE CODE: E = ESTRUS, D = DIESTRUS, M = METESTRUS, P = PROESTRUS T = FIRST DAY OF TREATMENT, B = FIRST DAY OF BREEDING PERIOD C = COPULATORY PLUG OBSERVED, + = SMEARED POSITIVE**Page 702 of 1107**TABLE A33 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ESTROUS CYCLE DATA

----------------------------------------------------------------------------------------------------------------------------------- FEMALES FROM GROUP 4: 175 PPM INDIVIDUAL -------------------------------------- MEAN LENGTH FEMALE DETERMINATION 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 OF ESTRUS NUMBER DAY: 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 CYCLE (DAYS)

----------------------------------------------------------------------------------------------------------------------------------- T B

----------------------------------------------------------------------------------------------------------------------------------- 91622 P E D D D E D D D E D D D E E D D D E E D D D E C 5.0 91623 E D D D E D D D E D D D E D D D E E D D D E E D D D P E D D D D D D D D D D D 5.0 91626 E D D D E D D D E D D D E D D D E E D D D P E D D D E C 5.0 91643 E D D D E D D D E D D D E E D D D P E E D D D D E E E D D E C 6.5 91654 D D E D D P E D D D E D D D E E D D D D D D D D E D D D P C 7.0 91657 D D D E D D D E D D D E D D D P D D D D E E D D D D D D D D D D D D P C 5.0 91662 D D D E D D D E D D D E D D D E E D D D P E D D D D C 5.0 91666 D E D D D E D D D E D D D E D D D D E E D D D D C 5.0 91676 D D E D D D E D D D E D D D P E D D D P E D D D D C 5.0 91678 D P E D D D E D D D E D D D E E D D E E D D D E + 4.5 91681 E D D D E D D D E D D D E D D E E E E D P D P D D D D D D D D D P C 3.3 91682 D D P E D D P E D D D E D D D D E D P D P E D D P E C 3.3

MEAN 5.0 S.D. 1.05 S.E. 0.30 N 12

----------------------------------------------------------------------------------------------------------------------------------- ESTROUS STAGE CODE: E = ESTRUS, D = DIESTRUS, M = METESTRUS, P = PROESTRUS T = FIRST DAY OF TREATMENT, B = FIRST DAY OF BREEDING PERIOD C = COPULATORY PLUG OBSERVED, + = SMEARED POSITIVE**Page 703 of 1107**TABLE A33 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ESTROUS CYCLE DATA

----------------------------------------------------------------------------------------------------------------------------------- FEMALES FROM GROUP 5: 10000 PPM INDIVIDUAL -------------------------------------- MEAN LENGTH FEMALE DETERMINATION 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 OF ESTRUS NUMBER DAY: 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 CYCLE (DAYS)

----------------------------------------------------------------------------------------------------------------------------------- T B

----------------------------------------------------------------------------------------------------------------------------------- 91624 D D E D D P E D D D E D D D E D D D E D D D E D D P C 4.0 91625 E D D D E D D D E D D D E E D D D P E D D D E D D D C 4.5 91627 D E D D D E D D D E D D D P E D D D E E D D D E + 5.0 91634 E D D D E D D D E D D D E D D D D D D D D E E D D D E C 10.0 91635 D D D E D D D E D D D E D D D P E D D D E D D D C 4.5 91638 D D D E D D D E D D D E D D D E E D D P E E D D D P + 5.0 91652 D D D E D D D E D D D E D D D E E D D D E D D D + 4.5 91655 D D E D D D E D D D E D D D E D D D E E D D D E C 4.5 91658 D E D D D E D D D E D D D D D D D D D D D D D D P C A 91667 D D D E D D D E D D D E D D D E E D D D E E D D D C 5.0 91668 D D D E D D D E D D D E D D D E E D D D E E D D D C 5.0 91680 E D D D E D D D E D D D E D D D E D D D E D D D C 4.0

MEAN 5.1 S.D. 1.67 S.E. 0.50 N 11

----------------------------------------------------------------------------------------------------------------------------------- ESTROUS STAGE CODE: E = ESTRUS, D = DIESTRUS, M = METESTRUS, P = PROESTRUS T = FIRST DAY OF TREATMENT, B = FIRST DAY OF BREEDING PERIOD A = UNABLE TO DETERMINE LENGTH OF ESTROUS CYCLE C = COPULATORY PLUG OBSERVED, + = SMEARED POSITIVE PCYCv5.29 01/07/2014**Page 704 of 1107**TABLE A34 (F0)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL REPRODUCTIVE PERFORMANCE

----------------------------------------------------------------------------------------------------------------------------------- GROUP 1: 0 PPM FEMALE FIRST SECOND DAYS PREGNANCY NUMBER MALE DATE MALE DATE PRE-COITUS STATUS

----------------------------------------------------------------------------------------------------------------------------------- 91629 91555 10/27/13 4 G 91630 91560 10/27/13 4 G 91633 91562 10/27/13 2 G 91637 91563 10/27/13 1 G 91639 91564 10/27/13 3 G 91644 91567 10/27/13 2 G 91645 91579 10/27/13 4 G 91648 91586 10/27/13 1 G 91653 91591 10/27/13 3 G 91660 91592 10/27/13 3 G 91670 91609 10/27/13 4 G 91672 91615 10/27/13 4 G

----------------------------------------------------------------------------------------------------------------------------------- G = GRAVID**Page 705 of 1107**TABLE A34 (F0)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL REPRODUCTIVE PERFORMANCE

----------------------------------------------------------------------------------------------------------------------------------- GROUP 2: 50 PPM FEMALE FIRST SECOND DAYS PREGNANCY NUMBER MALE DATE MALE DATE PRE-COITUS STATUS

----------------------------------------------------------------------------------------------------------------------------------- 91632 91556 10/27/13 5 G 91640 91559 10/27/13 5 G 91642 91561 10/27/13 2 G 91647 91566 10/27/13 4 G 91651 91576 10/27/13 2 G 91659 91582 10/27/13 2 G 91661 91585 10/27/13 1 G 91663 91589 10/27/13 3 G 91669 91593 10/27/13 1 G 91673 91594 10/27/13 4 G 91683 91595 10/27/13 5 G 91685 91602 10/27/13 1 G

----------------------------------------------------------------------------------------------------------------------------------- G = GRAVID**Page 706 of 1107**TABLE A34 (F0)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL REPRODUCTIVE PERFORMANCE

----------------------------------------------------------------------------------------------------------------------------------- GROUP 3: 100 PPM FEMALE FIRST SECOND DAYS PREGNANCY NUMBER MALE DATE MALE DATE PRE-COITUS STATUS

----------------------------------------------------------------------------------------------------------------------------------- 91620 91569 10/27/13 3 G 91628 91573 10/27/13 2 G 91631 91577 10/27/13 2 G 91636 91581 10/27/13 3 G 91649 91583 10/27/13 1 G 91650 91588 10/27/13 1 G 91656 91590 10/27/13 6 G 91671 91598 10/27/13 5 G 91675 91599 10/27/13 1 G 91677 91608 10/27/13 2 G 91679 91611 10/27/13 1 G 91684 91616 10/27/13 2 G

----------------------------------------------------------------------------------------------------------------------------------- G = GRAVID**Page 707 of 1107**TABLE A34 (F0)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL REPRODUCTIVE PERFORMANCE

----------------------------------------------------------------------------------------------------------------------------------- GROUP 4: 175 PPM FEMALE FIRST SECOND DAYS PREGNANCY NUMBER MALE DATE MALE DATE PRE-COITUS STATUS

----------------------------------------------------------------------------------------------------------------------------------- 91622 91565 10/27/13 1 G 91623 91568 10/27/13 B NG 91626 91570 10/27/13 4 G 91643 91572 10/27/13 7 G 91654 91580 10/27/13 6 G 91657 91584 10/27/13 12 G 91662 91587 10/27/13 3 G 91666 91597 10/27/13 1 G 91676 91601 10/27/13 2 G 91678 91607 10/27/13 1 G 91681 91613 10/27/13 10 G 91682 91614 10/27/13 3 G

----------------------------------------------------------------------------------------------------------------------------------- B = NO EVIDENCE OF MATING, G = GRAVID, NG = NONGRAVID**Page 708 of 1107**TABLE A34 (F0)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL REPRODUCTIVE PERFORMANCE

----------------------------------------------------------------------------------------------------------------------------------- GROUP 5: 10000 PPM FEMALE FIRST SECOND DAYS PREGNANCY NUMBER MALE DATE MALE DATE PRE-COITUS STATUS

----------------------------------------------------------------------------------------------------------------------------------- 91624 91554 10/27/13 3 G 91625 91557 10/27/13 3 G 91627 91558 10/27/13 1 G 91634 91571 10/27/13 4 G 91635 91575 10/27/13 1 G 91638 91600 10/27/13 3 G 91652 91603 10/27/13 1 G 91655 91604 10/27/13 1 G 91658 91605 10/27/13 2 G 91667 91612 10/27/13 2 G 91668 91618 10/27/13 2 G 91680 91619 10/27/13 1 G

----------------------------------------------------------------------------------------------------------------------------------- G = GRAVID PPAIRv4.09 01/07/2014 R:01/07/2014**Page 709 of 1107**TABLE A35 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL GESTATION LENGTHS [DAYS]

----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5

----------------------------------------------------------------------------------------------------------------------------------- GESTATION GESTATION GESTATION GESTATION GESTATION ANIMAL LENGTH ANIMAL LENGTH ANIMAL LENGTH ANIMAL LENGTH ANIMAL LENGTH

----------------------------------------------------------------------------------------------------------------------------------- 91629 21. 91632 22. 91620 23. 91622 22. 91624 22. 91630 22. 91640 22. 91628 22. 91626 22. 91625 23. 91633 21. 91642 22. 91631 22. 91643 22. 91627 22. 91637 21. 91647 22. 91636 22. 91654 23. 91634 22. 91639 22. 91651 23. 91649 22. 91657 22. 91635 22. 91644 21. 91659 22. 91650 22. 91662 23. 91638 22. 91645 22. 91661 22. 91656 22. 91666 23. 91652 22. 91648 22. 91663 22. 91671 23. 91676 23. 91655 22. 91653 22. 91669 22. 91675 23. 91678 23. 91658 22. 91660 22. 91673 22. 91677 23. 91681 23. 91667 22. 91670 22. 91683 22. 91679 22. 91682 23. 91668 22. 91672 22. 91685 22. 91684 22. 91680 22.

----------------------------------------------------------------------------------------------------------------------------------- MEAN 21.7 22.1 22.3 22.6 22.1 S.D. 0.49 0.29 0.49 0.50 0.29 S.E. 0.14 0.08 0.14 0.15 0.08 N 12 12 12 11 12

----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM PGLv5.10 01/07/2014**Page 710 of 1107**TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91629 F 0 PPM PARTURITION OBS 20 11/20/13 7:30 P NO PRE-DELIVERY FINDINGS 20 11/20/13 15:04 P NO PRE-DELIVERY FINDINGS 21 11/21/13 7:30 P NO PRE-DELIVERY FINDINGS 21 11/21/13 13:34 P PUPS PRESENT IN NESTING BOX 21 11/21/13 13:41 P NO SIGNIFICANT FINDINGS DURING PARTURITION 22 11/22/13 8:09 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91630 F 0 PPM PARTURITION OBS 20 11/20/13 7:31 P NO PRE-DELIVERY FINDINGS 20 11/20/13 15:04 P NO PRE-DELIVERY FINDINGS 21 11/21/13 7:30 P NO PRE-DELIVERY FINDINGS 21 11/21/13 13:34 P NO PRE-DELIVERY FINDINGS 22 11/22/13 7:30 P PUPS PRESENT IN NESTING BOX 22 11/22/13 9:06 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91633 F 0 PPM PARTURITION OBS 20 11/18/13 7:30 P NO PRE-DELIVERY FINDINGS 20 11/18/13 15:27 P NO PRE-DELIVERY FINDINGS 21 11/19/13 7:31 P NO PRE-DELIVERY FINDINGS 21 11/19/13 13:32 P PUPS PRESENT IN NESTING BOX 21 11/19/13 13:42 P NO SIGNIFICANT FINDINGS DURING PARTURITION 22 11/20/13 6:29 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91637 F 0 PPM PARTURITION OBS 20 11/17/13 7:31 P NO PRE-DELIVERY FINDINGS 20 11/17/13 14:28 P NO PRE-DELIVERY FINDINGS 21 11/18/13 7:31 P NO PRE-DELIVERY FINDINGS 21 11/18/13 13:42 P PUPS PRESENT IN NESTING BOX 21 11/18/13 14:02 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91639 F 0 PPM PARTURITION OBS 20 11/19/13 7:32 P NO PRE-DELIVERY FINDINGS 20 11/19/13 14:38 P NO PRE-DELIVERY FINDINGS 21 11/20/13 7:31 P NO PRE-DELIVERY FINDINGS 21 11/20/13 13:39 P NO PRE-DELIVERY FINDINGS 22 11/21/13 7:31 P NO PRE-DELIVERY FINDINGS 22 11/21/13 13:34 P PUPS PRESENT IN NESTING BOX 22 11/21/13 13:49 P NO SIGNIFICANT FINDINGS DURING PARTURITION

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY**Page 711 of 1107**TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91644 F 0 PPM PARTURITION OBS 20 11/18/13 7:31 P NO PRE-DELIVERY FINDINGS 20 11/18/13 15:27 P NO PRE-DELIVERY FINDINGS 21 11/19/13 7:31 P NO PRE-DELIVERY FINDINGS 21 11/19/13 13:33 P PUPS PRESENT IN NESTING BOX 21 11/19/13 13:48 P NO SIGNIFICANT FINDINGS DURING PARTURITION 22 11/20/13 6:45 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91645 F 0 PPM PARTURITION OBS 20 11/20/13 7:31 P NO PRE-DELIVERY FINDINGS 20 11/20/13 15:04 P NO PRE-DELIVERY FINDINGS 21 11/21/13 7:31 P NO PRE-DELIVERY FINDINGS 21 11/21/13 13:34 P NO PRE-DELIVERY FINDINGS 22 11/22/13 7:30 P PUPS PRESENT IN NESTING BOX 22 11/22/13 9:14 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91648 F 0 PPM PARTURITION OBS 20 11/17/13 7:31 P NO PRE-DELIVERY FINDINGS 20 11/17/13 14:26 P NO PRE-DELIVERY FINDINGS 21 11/18/13 7:31 P NO PRE-DELIVERY FINDINGS 21 11/18/13 13:42 P NO PRE-DELIVERY FINDINGS 22 11/19/13 7:31 P NO PRE-DELIVERY FINDINGS 22 11/19/13 13:33 P PUPS PRESENT IN NESTING BOX 22 11/19/13 13:53 P NO SIGNIFICANT FINDINGS DURING PARTURITION 23 11/20/13 7:00 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91653 F 0 PPM PARTURITION OBS 20 11/19/13 7:31 P NO PRE-DELIVERY FINDINGS 20 11/19/13 14:39 P NO PRE-DELIVERY FINDINGS 21 11/20/13 7:31 P NO PRE-DELIVERY FINDINGS 21 11/20/13 13:39 P NO PRE-DELIVERY FINDINGS 22 11/21/13 7:31 P PUPS PRESENT IN NESTING BOX 22 11/21/13 8:26 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91660 F 0 PPM PARTURITION OBS 20 11/19/13 7:32 P NO PRE-DELIVERY FINDINGS 20 11/19/13 14:39 P NO PRE-DELIVERY FINDINGS 21 11/20/13 7:32 P NO PRE-DELIVERY FINDINGS 21 11/20/13 13:39 P NO PRE-DELIVERY FINDINGS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY**Page 712 of 1107**TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91660 F 0 PPM PARTURITION OBS 22 11/21/13 7:31 P NO PRE-DELIVERY FINDINGS 22 11/21/13 13:35 P PUPS PRESENT IN NESTING BOX 22 11/21/13 13:56 P NO SIGNIFICANT FINDINGS DURING PARTURITION 23 11/22/13 8:15 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91670 F 0 PPM PARTURITION OBS 20 11/20/13 7:32 P NO PRE-DELIVERY FINDINGS 20 11/20/13 15:04 P NO PRE-DELIVERY FINDINGS 21 11/21/13 7:31 P NO PRE-DELIVERY FINDINGS 21 11/21/13 13:35 P NO PRE-DELIVERY FINDINGS 22 11/22/13 7:31 P PUPS PRESENT IN NESTING BOX 22 11/22/13 9:18 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91672 F 0 PPM PARTURITION OBS 20 11/20/13 7:32 P NO PRE-DELIVERY FINDINGS 20 11/20/13 15:05 P NO PRE-DELIVERY FINDINGS 21 11/21/13 7:32 P NO PRE-DELIVERY FINDINGS 21 11/21/13 13:35 P NO PRE-DELIVERY FINDINGS 22 11/22/13 7:31 P PUPS PRESENT IN NESTING BOX 22 11/22/13 9:21 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91632 F 50 PPM PARTURITION OBS 20 11/21/13 7:32 P NO PRE-DELIVERY FINDINGS 20 11/21/13 14:48 P NO PRE-DELIVERY FINDINGS 21 11/22/13 7:31 P NO PRE-DELIVERY FINDINGS 21 11/22/13 13:40 P NO PRE-DELIVERY FINDINGS 22 11/23/13 7:30 P NO PRE-DELIVERY FINDINGS 22 11/23/13 13:31 P PUPS PRESENT IN NESTING BOX 22 11/23/13 13:33 P NO SIGNIFICANT FINDINGS DURING PARTURITION 23 11/24/13 7:46 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91640 F 50 PPM PARTURITION OBS 20 11/21/13 7:32 P NO PRE-DELIVERY FINDINGS 20 11/21/13 14:48 P NO PRE-DELIVERY FINDINGS 21 11/22/13 7:31 P NO PRE-DELIVERY FINDINGS 21 11/22/13 13:40 P NO PRE-DELIVERY FINDINGS 22 11/23/13 7:30 P NO PRE-DELIVERY FINDINGS 22 11/23/13 13:31 P PUPS PRESENT IN NESTING BOX

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY**Page 713 of 1107**TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91640 F 50 PPM PARTURITION OBS 22 11/23/13 13:35 P NO SIGNIFICANT FINDINGS DURING PARTURITION 23 11/24/13 7:50 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91642 F 50 PPM PARTURITION OBS 20 11/18/13 7:31 P NO PRE-DELIVERY FINDINGS 20 11/18/13 15:27 P NO PRE-DELIVERY FINDINGS 21 11/19/13 7:32 P NO PRE-DELIVERY FINDINGS 21 11/19/13 13:34 P NO PRE-DELIVERY FINDINGS 22 11/20/13 7:32 P NO PRE-DELIVERY FINDINGS 22 11/20/13 13:40 P PUPS PRESENT IN NESTING BOX 22 11/20/13 13:48 P NO SIGNIFICANT FINDINGS DURING PARTURITION 22 11/20/13 14:24 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91647 F 50 PPM PARTURITION OBS 20 11/20/13 7:32 P NO PRE-DELIVERY FINDINGS 20 11/20/13 15:07 P NO PRE-DELIVERY FINDINGS 21 11/21/13 7:32 P NO PRE-DELIVERY FINDINGS 21 11/21/13 13:35 P NO PRE-DELIVERY FINDINGS 22 11/22/13 7:32 P NO PRE-DELIVERY FINDINGS 22 11/22/13 13:41 P PUPS PRESENT IN NESTING BOX 22 11/22/13 13:47 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91651 F 50 PPM PARTURITION OBS 20 11/18/13 7:32 P NO PRE-DELIVERY FINDINGS 20 11/18/13 15:27 P NO PRE-DELIVERY FINDINGS 21 11/19/13 7:32 P NO PRE-DELIVERY FINDINGS 21 11/19/13 13:34 P NO PRE-DELIVERY FINDINGS 22 11/20/13 7:33 P NO PRE-DELIVERY FINDINGS 22 11/20/13 13:39 P NO PRE-DELIVERY FINDINGS 23 11/21/13 7:32 P PUPS PRESENT IN NESTING BOX 23 11/21/13 8:30 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91659 F 50 PPM PARTURITION OBS 20 11/18/13 7:32 P NO PRE-DELIVERY FINDINGS 20 11/18/13 15:28 P NO PRE-DELIVERY FINDINGS 21 11/19/13 7:33 P NO PRE-DELIVERY FINDINGS 21 11/19/13 13:34 P NO PRE-DELIVERY FINDINGS 22 11/20/13 7:33 P NO PRE-DELIVERY FINDINGS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY**Page 714 of 1107**TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91659 F 50 PPM PARTURITION OBS 22 11/20/13 13:40 P PUPS PRESENT IN NESTING BOX 22 11/20/13 13:57 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91661 F 50 PPM PARTURITION OBS 20 11/17/13 7:31 P NO PRE-DELIVERY FINDINGS 20 11/17/13 14:49 P NO PRE-DELIVERY FINDINGS 21 11/18/13 7:32 P NO PRE-DELIVERY FINDINGS 21 11/18/13 13:43 P NO PRE-DELIVERY FINDINGS 22 11/19/13 7:33 P PUPS PRESENT IN NESTING BOX 22 11/19/13 7:42 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91663 F 50 PPM PARTURITION OBS 20 11/19/13 7:33 P NO PRE-DELIVERY FINDINGS 20 11/19/13 14:57 P NO PRE-DELIVERY FINDINGS 21 11/20/13 7:33 P NO PRE-DELIVERY FINDINGS 21 11/20/13 13:40 P NO PRE-DELIVERY FINDINGS 22 11/21/13 7:32 P NO PRE-DELIVERY FINDINGS 22 11/21/13 13:36 P PUPS PRESENT IN NESTING BOX 22 11/21/13 13:57 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91669 F 50 PPM PARTURITION OBS 20 11/17/13 7:31 P NO PRE-DELIVERY FINDINGS 20 11/17/13 14:50 P NO PRE-DELIVERY FINDINGS 21 11/18/13 7:32 P NO PRE-DELIVERY FINDINGS 21 11/18/13 13:43 P NO PRE-DELIVERY FINDINGS 22 11/19/13 7:33 P NO PRE-DELIVERY FINDINGS 22 11/19/13 13:35 P PUPS PRESENT IN NESTING BOX 22 11/19/13 14:02 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91673 F 50 PPM PARTURITION OBS 20 11/20/13 7:33 P NO PRE-DELIVERY FINDINGS 20 11/20/13 15:08 P NO PRE-DELIVERY FINDINGS 21 11/21/13 7:33 P NO PRE-DELIVERY FINDINGS 21 11/21/13 13:36 P NO PRE-DELIVERY FINDINGS 22 11/22/13 7:32 P NO PRE-DELIVERY FINDINGS 22 11/22/13 13:41 P PUPS PRESENT IN NESTING BOX 22 11/22/13 13:58 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91683 F 50 PPM PARTURITION OBS 20 11/21/13 7:33 P NO PRE-DELIVERY FINDINGS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY**Page 715 of 1107**TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91683 F 50 PPM PARTURITION OBS 20 11/21/13 14:47 P NO PRE-DELIVERY FINDINGS 21 11/22/13 7:32 P NO PRE-DELIVERY FINDINGS 21 11/22/13 13:41 P NO PRE-DELIVERY FINDINGS 22 11/23/13 7:31 P NO PRE-DELIVERY FINDINGS 22 11/23/13 13:31 P PUPS PRESENT IN NESTING BOX 22 11/23/13 13:43 P NO SIGNIFICANT FINDINGS DURING PARTURITION 23 11/24/13 7:54 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91685 F 50 PPM PARTURITION OBS 20 11/17/13 7:31 P NO PRE-DELIVERY FINDINGS 20 11/17/13 14:49 P NO PRE-DELIVERY FINDINGS 21 11/18/13 7:33 P NO PRE-DELIVERY FINDINGS 21 11/18/13 13:44 P NO PRE-DELIVERY FINDINGS 22 11/19/13 7:34 P NO PRE-DELIVERY FINDINGS 22 11/19/13 13:35 P PUPS PRESENT IN NESTING BOX 22 11/19/13 14:09 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91620 F 100 PPM PARTURITION OBS 20 11/19/13 7:34 P NO PRE-DELIVERY FINDINGS 20 11/19/13 14:55 P NO PRE-DELIVERY FINDINGS 21 11/20/13 7:34 P NO PRE-DELIVERY FINDINGS 21 11/20/13 13:41 P NO PRE-DELIVERY FINDINGS 22 11/21/13 7:33 P NO PRE-DELIVERY FINDINGS 22 11/21/13 13:36 P VAGINAL DISCHARGE/MATERIAL 23 11/22/13 7:32 P PUPS PRESENT IN NESTING BOX 23 11/22/13 9:27 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91628 F 100 PPM PARTURITION OBS 20 11/18/13 7:33 P NO PRE-DELIVERY FINDINGS 20 11/18/13 15:28 P NO PRE-DELIVERY FINDINGS 21 11/19/13 7:34 P NO PRE-DELIVERY FINDINGS 21 11/19/13 13:35 P NO PRE-DELIVERY FINDINGS 22 11/20/13 7:34 P NO PRE-DELIVERY FINDINGS 22 11/20/13 13:41 P PUPS PRESENT IN NESTING BOX 22 11/20/13 14:02 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91631 F 100 PPM PARTURITION OBS 20 11/18/13 7:34 P NO PRE-DELIVERY FINDINGS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY**Page 716 of 1107**TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91631 F 100 PPM PARTURITION OBS 20 11/18/13 15:28 P NO PRE-DELIVERY FINDINGS 21 11/19/13 7:35 P NO PRE-DELIVERY FINDINGS 21 11/19/13 13:35 P NO PRE-DELIVERY FINDINGS 22 11/20/13 7:34 P PUPS PRESENT IN NESTING BOX 22 11/20/13 8:23 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91636 F 100 PPM PARTURITION OBS 20 11/19/13 7:35 P NO PRE-DELIVERY FINDINGS 20 11/19/13 14:56 P NO PRE-DELIVERY FINDINGS 21 11/20/13 7:34 P NO PRE-DELIVERY FINDINGS 21 11/20/13 13:41 P NO PRE-DELIVERY FINDINGS 22 11/21/13 7:33 P NO PRE-DELIVERY FINDINGS 22 11/21/13 13:36 P PUPS PRESENT IN NESTING BOX 22 11/21/13 13:41 P NO SIGNIFICANT FINDINGS DURING PARTURITION 23 11/22/13 8:19 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91649 F 100 PPM PARTURITION OBS 20 11/17/13 7:32 P NO PRE-DELIVERY FINDINGS 20 11/17/13 14:54 P NO PRE-DELIVERY FINDINGS 21 11/18/13 7:34 P NO PRE-DELIVERY FINDINGS 21 11/18/13 13:44 P NO PRE-DELIVERY FINDINGS 22 11/19/13 7:35 P NO PRE-DELIVERY FINDINGS 22 11/19/13 13:36 P PUPS PRESENT IN NESTING BOX 22 11/19/13 14:14 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91650 F 100 PPM PARTURITION OBS 20 11/17/13 7:32 P NO PRE-DELIVERY FINDINGS 20 11/17/13 14:56 P NO PRE-DELIVERY FINDINGS 21 11/18/13 7:34 P NO PRE-DELIVERY FINDINGS 21 11/18/13 13:45 P NO PRE-DELIVERY FINDINGS 22 11/19/13 7:35 P NO PRE-DELIVERY FINDINGS 22 11/19/13 13:36 P PUPS PRESENT IN NESTING BOX 22 11/19/13 14:22 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91656 F 100 PPM PARTURITION OBS 20 11/22/13 7:33 P NO PRE-DELIVERY FINDINGS 20 11/22/13 14:36 P NO PRE-DELIVERY FINDINGS 21 11/23/13 7:31 P NO PRE-DELIVERY FINDINGS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY**Page 717 of 1107**TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91656 F 100 PPM PARTURITION OBS 21 11/23/13 13:31 P NO PRE-DELIVERY FINDINGS 22 11/24/13 7:30 P NO PRE-DELIVERY FINDINGS 22 11/24/13 13:31 P PUPS PRESENT IN NESTING BOX 22 11/24/13 13:35 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91671 F 100 PPM PARTURITION OBS 20 11/21/13 7:33 P NO PRE-DELIVERY FINDINGS 20 11/21/13 14:54 P NO PRE-DELIVERY FINDINGS 21 11/22/13 7:33 P NO PRE-DELIVERY FINDINGS 21 11/22/13 13:41 P NO PRE-DELIVERY FINDINGS 22 11/23/13 7:31 P NO PRE-DELIVERY FINDINGS 22 11/23/13 13:32 P VAGINAL DISCHARGE/MATERIAL 23 11/24/13 7:30 P PUPS PRESENT IN NESTING BOX 23 11/24/13 7:57 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91675 F 100 PPM PARTURITION OBS 20 11/17/13 7:32 P NO PRE-DELIVERY FINDINGS 20 11/17/13 14:53 P NO PRE-DELIVERY FINDINGS 21 11/18/13 7:34 P NO PRE-DELIVERY FINDINGS 21 11/18/13 13:45 P NO PRE-DELIVERY FINDINGS 22 11/19/13 7:36 P NO PRE-DELIVERY FINDINGS 22 11/19/13 13:37 P NO PRE-DELIVERY FINDINGS 23 11/20/13 7:34 P PUPS PRESENT IN NESTING BOX 23 11/20/13 8:31 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91677 F 100 PPM PARTURITION OBS 20 11/18/13 7:34 P NO PRE-DELIVERY FINDINGS 20 11/18/13 15:28 P NO PRE-DELIVERY FINDINGS 21 11/19/13 7:36 P NO PRE-DELIVERY FINDINGS 21 11/19/13 13:37 P NO PRE-DELIVERY FINDINGS 22 11/20/13 7:35 P NO PRE-DELIVERY FINDINGS 22 11/20/13 13:42 P NO PRE-DELIVERY FINDINGS 23 11/21/13 7:33 P NO PRE-DELIVERY FINDINGS 23 11/21/13 13:37 P PUPS PRESENT IN NESTING BOX 23 11/21/13 13:46 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91679 F 100 PPM PARTURITION OBS 20 11/17/13 7:32 P NO PRE-DELIVERY FINDINGS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY**Page 718 of 1107**TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91679 F 100 PPM PARTURITION OBS 20 11/17/13 14:53 P NO PRE-DELIVERY FINDINGS 21 11/18/13 7:35 P NO PRE-DELIVERY FINDINGS 21 11/18/13 13:46 P NO PRE-DELIVERY FINDINGS 22 11/19/13 7:36 P NO PRE-DELIVERY FINDINGS 22 11/19/13 13:37 P PUPS PRESENT IN NESTING BOX 22 11/19/13 14:27 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91684 F 100 PPM PARTURITION OBS 20 11/18/13 7:35 P NO PRE-DELIVERY FINDINGS 20 11/18/13 15:29 P NO PRE-DELIVERY FINDINGS 21 11/19/13 7:36 P NO PRE-DELIVERY FINDINGS 21 11/19/13 13:37 P NO PRE-DELIVERY FINDINGS 22 11/20/13 7:35 P NO PRE-DELIVERY FINDINGS 22 11/20/13 13:42 P PUPS PRESENT IN NESTING BOX 22 11/20/13 14:14 P NO SIGNIFICANT FINDINGS DURING PARTURITION 23 11/21/13 8:18 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91622 F 175 PPM PARTURITION OBS 20 11/17/13 7:32 P NO PRE-DELIVERY FINDINGS 20 11/17/13 15:00 P NO PRE-DELIVERY FINDINGS 21 11/18/13 7:35 P NO PRE-DELIVERY FINDINGS 21 11/18/13 13:46 P VAGINAL DISCHARGE/MATERIAL 22 11/19/13 7:37 P NO PRE-DELIVERY FINDINGS 22 11/19/13 13:38 P PUPS PRESENT IN NESTING BOX 22 11/19/13 14:23 P NO SIGNIFICANT FINDINGS DURING PARTURITION 23 11/20/13 7:10 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91623 F 175 PPM PARTURITION OBS - 11/17/13 7:32 P NO PRE-DELIVERY FINDINGS - 11/17/13 14:57 P NO PRE-DELIVERY FINDINGS - 11/18/13 7:35 P NO PRE-DELIVERY FINDINGS - 11/18/13 15:29 P NO PRE-DELIVERY FINDINGS - 11/19/13 7:37 P NO PRE-DELIVERY FINDINGS - 11/19/13 14:53 P NO PRE-DELIVERY FINDINGS - 11/20/13 7:35 P NO PRE-DELIVERY FINDINGS - 11/20/13 15:10 P NO PRE-DELIVERY FINDINGS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY**Page 719 of 1107**TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91623 F 175 PPM PARTURITION OBS - 11/21/13 7:34 P NO PRE-DELIVERY FINDINGS - 11/21/13 14:49 P NO PRE-DELIVERY FINDINGS - 11/22/13 7:33 P NO PRE-DELIVERY FINDINGS - 11/22/13 14:36 P NO PRE-DELIVERY FINDINGS - 11/23/13 7:31 P NO PRE-DELIVERY FINDINGS - 11/23/13 14:30 P NO PRE-DELIVERY FINDINGS - 11/24/13 7:31 P NO PRE-DELIVERY FINDINGS - 11/24/13 14:38 P NO PRE-DELIVERY FINDINGS - 11/25/13 7:30 P NO PRE-DELIVERY FINDINGS - 11/25/13 14:39 P NO PRE-DELIVERY FINDINGS - 11/26/13 7:31 P NO PRE-DELIVERY FINDINGS - 11/26/13 14:46 P NO PRE-DELIVERY FINDINGS - 11/27/13 7:30 P NO PRE-DELIVERY FINDINGS - 11/27/13 14:20 P NO PRE-DELIVERY FINDINGS - 11/28/13 7:30 P NO PRE-DELIVERY FINDINGS - 11/28/13 14:16 P NO PRE-DELIVERY FINDINGS - 11/29/13 7:30 P NO PRE-DELIVERY FINDINGS - 11/29/13 14:12 P NO PRE-DELIVERY FINDINGS - 11/30/13 7:31 P NO PRE-DELIVERY FINDINGS - 11/30/13 14:03 P NO PRE-DELIVERY FINDINGS - 12/01/13 7:31 P NO PRE-DELIVERY FINDINGS - 12/01/13 14:02 P NO PRE-DELIVERY FINDINGS - 12/02/13 7:32 P NO PRE-DELIVERY FINDINGS - 12/02/13 14:23 P NO PRE-DELIVERY FINDINGS - 12/03/13 7:30 P NO PRE-DELIVERY FINDINGS - 12/03/13 14:25 P NO PRE-DELIVERY FINDINGS - 12/04/13 7:30 P NO PRE-DELIVERY FINDINGS - 12/04/13 14:41 P NO PRE-DELIVERY FINDINGS * - 12/05/13 8:15 P NO PRE-DELIVERY FINDINGS * 91626 F 175 PPM PARTURITION OBS 20 11/20/13 7:35 P NO PRE-DELIVERY FINDINGS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY * - LATE COMPUTER ENTRY OBSERVATIONS FOR ABOVE DATES**Page 720 of 1107**TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 11 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91626 F 175 PPM PARTURITION OBS 20 11/20/13 15:11 P NO PRE-DELIVERY FINDINGS 21 11/21/13 7:34 P NO PRE-DELIVERY FINDINGS 21 11/21/13 13:37 P NO PRE-DELIVERY FINDINGS 22 11/22/13 7:33 P NO PRE-DELIVERY FINDINGS 22 11/22/13 13:42 P PUPS PRESENT IN NESTING BOX 22 11/22/13 14:06 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91643 F 175 PPM PARTURITION OBS 20 11/23/13 7:31 P NO PRE-DELIVERY FINDINGS 20 11/23/13 14:30 P NO PRE-DELIVERY FINDINGS 21 11/24/13 7:31 P NO PRE-DELIVERY FINDINGS 21 11/24/13 13:32 P NO PRE-DELIVERY FINDINGS 22 11/25/13 7:30 P NO PRE-DELIVERY FINDINGS 22 11/25/13 13:33 P PUPS PRESENT IN NESTING BOX 22 11/25/13 13:33 P NO SIGNIFICANT FINDINGS DURING PARTURITION 23 11/26/13 7:55 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91654 F 175 PPM PARTURITION OBS 20 11/22/13 7:33 P NO PRE-DELIVERY FINDINGS 20 11/22/13 14:36 P NO PRE-DELIVERY FINDINGS 21 11/23/13 7:32 P NO PRE-DELIVERY FINDINGS 21 11/23/13 13:32 P NO PRE-DELIVERY FINDINGS 22 11/24/13 7:31 P NO PRE-DELIVERY FINDINGS 22 11/24/13 13:32 P NO PRE-DELIVERY FINDINGS 23 11/25/13 7:31 P NO PRE-DELIVERY FINDINGS 23 11/25/13 13:33 P PUPS PRESENT IN NESTING BOX 23 11/25/13 13:42 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91657 F 175 PPM PARTURITION OBS 20 11/28/13 7:30 P NO PRE-DELIVERY FINDINGS 20 11/28/13 14:17 P NO PRE-DELIVERY FINDINGS 21 11/29/13 7:30 P NO PRE-DELIVERY FINDINGS 21 11/29/13 14:12 P NO PRE-DELIVERY FINDINGS 22 11/30/13 7:31 P NO PRE-DELIVERY FINDINGS 22 11/30/13 13:37 P PUPS PRESENT IN NESTING BOX 22 11/30/13 14:04 P NO SIGNIFICANT FINDINGS DURING PARTURITION

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY**Page 721 of 1107**TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 12 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91657 F 175 PPM PARTURITION OBS 23 12/01/13 6:29 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91662 F 175 PPM PARTURITION OBS 20 11/19/13 7:37 P NO PRE-DELIVERY FINDINGS 20 11/19/13 14:53 P NO PRE-DELIVERY FINDINGS 21 11/20/13 7:35 P NO PRE-DELIVERY FINDINGS 21 11/20/13 13:42 P NO PRE-DELIVERY FINDINGS 22 11/21/13 7:34 P NO PRE-DELIVERY FINDINGS 22 11/21/13 13:37 P NO PRE-DELIVERY FINDINGS 23 11/22/13 7:34 P PUPS PRESENT IN NESTING BOX 23 11/22/13 9:32 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91666 F 175 PPM PARTURITION OBS 20 11/17/13 7:32 P NO PRE-DELIVERY FINDINGS 20 11/17/13 14:57 P NO PRE-DELIVERY FINDINGS 21 11/18/13 7:35 P NO PRE-DELIVERY FINDINGS 21 11/18/13 13:47 P NO PRE-DELIVERY FINDINGS 22 11/19/13 7:37 P NO PRE-DELIVERY FINDINGS 22 11/19/13 13:38 P NO PRE-DELIVERY FINDINGS 23 11/20/13 7:36 P PUPS PRESENT IN NESTING BOX 23 11/20/13 8:36 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91676 F 175 PPM PARTURITION OBS 20 11/18/13 7:36 P NO PRE-DELIVERY FINDINGS 20 11/18/13 15:30 P NO PRE-DELIVERY FINDINGS 21 11/19/13 7:38 P NO PRE-DELIVERY FINDINGS 21 11/19/13 13:38 P NO PRE-DELIVERY FINDINGS 22 11/20/13 7:36 P NO PRE-DELIVERY FINDINGS 22 11/20/13 13:43 P VAGINAL DISCHARGE/MATERIAL 23 11/21/13 7:34 P PUPS PRESENT IN NESTING BOX 23 11/21/13 8:35 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91678 F 175 PPM PARTURITION OBS 20 11/17/13 7:32 P NO PRE-DELIVERY FINDINGS 20 11/17/13 15:00 P NO PRE-DELIVERY FINDINGS 21 11/18/13 7:36 P NO PRE-DELIVERY FINDINGS 21 11/18/13 13:47 P NO PRE-DELIVERY FINDINGS 22 11/19/13 7:38 P NO PRE-DELIVERY FINDINGS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY**Page 722 of 1107**TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 13 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91678 F 175 PPM PARTURITION OBS 22 11/19/13 13:39 P NO PRE-DELIVERY FINDINGS 23 11/20/13 7:36 P PUPS PRESENT IN NESTING BOX 23 11/20/13 8:46 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91681 F 175 PPM PARTURITION OBS 20 11/26/13 7:31 P NO PRE-DELIVERY FINDINGS 20 11/26/13 14:46 P NO PRE-DELIVERY FINDINGS 21 11/27/13 7:30 P NO PRE-DELIVERY FINDINGS 21 11/27/13 14:00 P NO PRE-DELIVERY FINDINGS 22 11/28/13 7:30 P NO PRE-DELIVERY FINDINGS 22 11/28/13 14:24 P NO PRE-DELIVERY FINDINGS 23 11/29/13 7:30 P PUPS PRESENT IN NESTING BOX 23 11/29/13 7:38 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91682 F 175 PPM PARTURITION OBS 20 11/19/13 7:38 P NO PRE-DELIVERY FINDINGS 20 11/19/13 14:53 P NO PRE-DELIVERY FINDINGS 21 11/20/13 7:36 P NO PRE-DELIVERY FINDINGS 21 11/20/13 13:43 P NO PRE-DELIVERY FINDINGS 22 11/21/13 7:34 P NO PRE-DELIVERY FINDINGS 22 11/21/13 13:37 P NO PRE-DELIVERY FINDINGS 23 11/22/13 7:34 P NO PRE-DELIVERY FINDINGS 23 11/22/13 13:42 P PUPS PRESENT IN NESTING BOX 23 11/22/13 14:11 P NO SIGNIFICANT FINDINGS DURING PARTURITION 24 11/23/13 7:50 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91624 F 10000 PPM PARTURITION OBS 20 11/19/13 7:39 P NO PRE-DELIVERY FINDINGS 20 11/19/13 14:36 P NO PRE-DELIVERY FINDINGS 21 11/20/13 7:37 P NO PRE-DELIVERY FINDINGS 21 11/20/13 13:43 P NO PRE-DELIVERY FINDINGS 22 11/21/13 7:35 P NO PRE-DELIVERY FINDINGS 22 11/21/13 13:38 P PUPS PRESENT IN NESTING BOX 22 11/21/13 13:49 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91625 F 10000 PPM PARTURITION OBS 20 11/19/13 7:39 P NO PRE-DELIVERY FINDINGS 20 11/19/13 14:35 P NO PRE-DELIVERY FINDINGS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY**Page 723 of 1107**TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 14 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91625 F 10000 PPM PARTURITION OBS 21 11/20/13 7:37 P NO PRE-DELIVERY FINDINGS 21 11/20/13 13:44 P NO PRE-DELIVERY FINDINGS 22 11/21/13 7:35 P NO PRE-DELIVERY FINDINGS 22 11/21/13 13:38 P NO PRE-DELIVERY FINDINGS 23 11/22/13 7:34 P PUPS PRESENT IN NESTING BOX 23 11/22/13 9:41 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91627 F 10000 PPM PARTURITION OBS 20 11/17/13 7:33 P NO PRE-DELIVERY FINDINGS 20 11/17/13 14:34 P NO PRE-DELIVERY FINDINGS 21 11/18/13 7:36 P NO PRE-DELIVERY FINDINGS 21 11/18/13 13:48 P NO PRE-DELIVERY FINDINGS 22 11/19/13 7:39 P NO PRE-DELIVERY FINDINGS 22 11/19/13 13:39 P PUPS PRESENT IN NESTING BOX 22 11/19/13 13:50 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91634 F 10000 PPM PARTURITION OBS 20 11/20/13 7:37 P NO PRE-DELIVERY FINDINGS 20 11/20/13 15:05 P NO PRE-DELIVERY FINDINGS 21 11/21/13 7:35 P NO PRE-DELIVERY FINDINGS 21 11/21/13 13:39 P NO PRE-DELIVERY FINDINGS 22 11/22/13 7:34 P NO PRE-DELIVERY FINDINGS 22 11/22/13 13:42 P PUPS PRESENT IN NESTING BOX 22 11/22/13 14:22 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91635 F 10000 PPM PARTURITION OBS 20 11/17/13 7:33 P NO PRE-DELIVERY FINDINGS 20 11/17/13 14:32 P NO PRE-DELIVERY FINDINGS 21 11/18/13 7:36 P NO PRE-DELIVERY FINDINGS 21 11/18/13 13:48 P NO PRE-DELIVERY FINDINGS 22 11/19/13 7:39 P NO PRE-DELIVERY FINDINGS 22 11/19/13 13:40 P PUPS PRESENT IN NESTING BOX 22 11/19/13 13:56 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91638 F 10000 PPM PARTURITION OBS 20 11/19/13 7:40 P NO PRE-DELIVERY FINDINGS 20 11/19/13 14:36 P NO PRE-DELIVERY FINDINGS 21 11/20/13 7:37 P NO PRE-DELIVERY FINDINGS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY**Page 724 of 1107**TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 15 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91638 F 10000 PPM PARTURITION OBS 21 11/20/13 13:44 P NO PRE-DELIVERY FINDINGS 22 11/21/13 7:35 P NO PRE-DELIVERY FINDINGS 22 11/21/13 13:39 P PUPS PRESENT IN NESTING BOX 22 11/21/13 13:53 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91652 F 10000 PPM PARTURITION OBS 20 11/17/13 7:33 P NO PRE-DELIVERY FINDINGS 20 11/17/13 14:34 P NO PRE-DELIVERY FINDINGS 21 11/18/13 7:36 P NO PRE-DELIVERY FINDINGS 21 11/18/13 13:49 P NO PRE-DELIVERY FINDINGS 22 11/19/13 7:40 P NO PRE-DELIVERY FINDINGS 22 11/19/13 13:39 P PUPS PRESENT IN NESTING BOX 22 11/19/13 14:13 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91655 F 10000 PPM PARTURITION OBS 20 11/17/13 7:33 P NO PRE-DELIVERY FINDINGS 20 11/17/13 14:31 P NO PRE-DELIVERY FINDINGS 21 11/18/13 7:37 P NO PRE-DELIVERY FINDINGS 21 11/18/13 13:49 P NO PRE-DELIVERY FINDINGS 22 11/19/13 7:40 P NO PRE-DELIVERY FINDINGS 22 11/19/13 13:39 P PUPS PRESENT IN NESTING BOX 22 11/19/13 14:18 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91658 F 10000 PPM PARTURITION OBS 20 11/18/13 7:37 P NO PRE-DELIVERY FINDINGS 20 11/18/13 15:30 P NO PRE-DELIVERY FINDINGS 21 11/19/13 7:40 P NO PRE-DELIVERY FINDINGS 21 11/19/13 13:40 P NO PRE-DELIVERY FINDINGS 22 11/20/13 7:37 P PUPS PRESENT IN NESTING BOX 22 11/20/13 8:54 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91667 F 10000 PPM PARTURITION OBS 20 11/18/13 7:37 P NO PRE-DELIVERY FINDINGS 20 11/18/13 15:31 P NO PRE-DELIVERY FINDINGS 21 11/19/13 7:41 P NO PRE-DELIVERY FINDINGS 21 11/19/13 13:40 P NO PRE-DELIVERY FINDINGS 22 11/20/13 7:37 P PUPS PRESENT IN NESTING BOX 22 11/20/13 8:59 P NO SIGNIFICANT FINDINGS DURING PARTURITION

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY**Page 725 of 1107**TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 16 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91668 F 10000 PPM PARTURITION OBS 20 11/18/13 7:37 P NO PRE-DELIVERY FINDINGS 20 11/18/13 15:31 P NO PRE-DELIVERY FINDINGS 21 11/19/13 7:41 P NO PRE-DELIVERY FINDINGS 21 11/19/13 13:40 P NO PRE-DELIVERY FINDINGS 22 11/20/13 7:38 P NO PRE-DELIVERY FINDINGS 22 11/20/13 13:44 P PUPS PRESENT IN NESTING BOX 22 11/20/13 14:20 P NO SIGNIFICANT FINDINGS DURING PARTURITION 23 11/21/13 8:22 P NO SIGNIFICANT FINDINGS DURING PARTURITION 91680 F 10000 PPM PARTURITION OBS 20 11/17/13 7:33 P NO PRE-DELIVERY FINDINGS 20 11/17/13 14:35 P NO PRE-DELIVERY FINDINGS 21 11/18/13 7:37 P NO PRE-DELIVERY FINDINGS 21 11/18/13 13:49 P NO PRE-DELIVERY FINDINGS 22 11/19/13 7:41 P PUPS PRESENT IN NESTING BOX 22 11/19/13 7:54 P NO SIGNIFICANT FINDINGS DURING PARTURITION

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY PPOCRDv1.05 01/07/2014**Page 726 of 1107**TABLE A37 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL SPERM MOTILITY AND CONCENTRATION

0 PPM SPERM PROGRESSIVE CAUDA EPID, LT TESTIS, LT PRODUCTION ANIMAL MOTILITY MOTILITY WEIGHT CONC WEIGHT CONC RATE

----------------------------------------------------------------------------------------------------------------------------------- 91555 86. 70. 0.2512 769.8 1.52 98.9 16.2 91560 72. 48. 0.2944 390.3 1.69 98.3 16.1 91562 84. 72. 0.2560 775.0 1.56 125.4 20.6 91563 86. 66. 0.2791 467.2 1.65 113.1 18.5 91564 82. 61. 0.2773 677.4 1.64 85.3 14.0 91567 78. 63. 0.2696 819.7 1.59 97.3 15.9 91579 72. 55. 0.2849 842.2 1.66 75.0 12.3 91586 71. 57. 0.2795 524.5 1.61 102.5 16.8 91591 70. 49. 0.2775 857.6 1.70 106.0 17.4 91592 78. 60. 0.3003 529.3 1.76 92.1 15.1 91609 75. 59. 0.3171 782.7 1.78 113.3 18.6 91615 68. 53. 0.3024 528.2 1.64 96.9 15.9

MEAN 77. 59. 0.2824 663.7 1.65 100.3 16.4 S.D. 6.5 7.6 0.01902 165.40 0.076 13.34 2.19 S.E. 1.9 2.2 0.00549 47.75 0.022 3.85 0.63 N 12 12 12 12 12 12 12

UNITS: MOTILITY (%), WEIGHT (GRAMS), CONCENTRATION (MILLIONS/GRAM), PRODUCTION RATE (MILLIONS/GRAM/DAY)**Page 727 of 1107**TABLE A37 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL SPERM MOTILITY AND CONCENTRATION

50 PPM SPERM PROGRESSIVE CAUDA EPID, LT TESTIS, LT PRODUCTION ANIMAL MOTILITY MOTILITY WEIGHT CONC WEIGHT CONC RATE

----------------------------------------------------------------------------------------------------------------------------------- 91556 79. 62. 0.2826 547.4 1.67 103.9 17.0 91559 83. 69. 0.2970 760.6 1.79 88.8 14.6 91561 68. 52. 0.3222 792.6 1.61 84.2 13.8 91566 69. 59. 0.2596 428.5 1.73 93.7 15.4 91576 79. 64. 0.2934 795.7 1.67 82.9 13.6 91582 84. 71. 0.3067 494.8 1.90 66.7 10.9 91585 77. 62. 0.2929 684.1 1.72 92.1 15.1 91589 74. 61. 0.2590 557.5 1.53 105.9 17.4 91593 73. 55. 0.2649 897.8 1.47 130.3 21.4 91594 68. 50. 0.3126 370.0 1.62 148.4 24.3 91595 78. 64. 0.3439 607.8 1.70 89.3 14.6 91602 73. 56. 0.3050 693.5 1.81 114.5 18.8

MEAN 75. 60. 0.2950 635.8 1.69 100.0 16.4 S.D. 5.5 6.4 0.02576 161.90 0.119 22.38 3.67 S.E. 1.6 1.8 0.00744 46.74 0.034 6.46 1.06 N 12 12 12 12 12 12 12

UNITS: MOTILITY (%), WEIGHT (GRAMS), CONCENTRATION (MILLIONS/GRAM), PRODUCTION RATE (MILLIONS/GRAM/DAY)**Page 728 of 1107**TABLE A37 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL SPERM MOTILITY AND CONCENTRATION

100 PPM SPERM PROGRESSIVE CAUDA EPID, LT TESTIS, LT PRODUCTION ANIMAL MOTILITY MOTILITY WEIGHT CONC WEIGHT CONC RATE

----------------------------------------------------------------------------------------------------------------------------------- 91569 56. 45. 0.2398 442.4 1.48 109.0 17.9 91573 76. 58. 0.2993 848.2 1.86 97.4 16.0 91577 83. 69. 0.2611 710.3 1.57 85.4 14.0 91581 77. 58. 0.3040 508.9 1.59 100.0 16.4 91583 68. 58. 0.2789 784.8 1.74 111.1 18.2 91588 71. 58. 0.2997 467.0 1.85 79.6 13.1 91590 75. 60. 0.2844 661.3 1.55 131.8 21.6 91598 70. 47. 0.2715 599.8 1.55 105.0 17.2 91599 77. 64. 0.2566 496.6 1.52 93.0 15.3 91608 77. 61. 0.2618 776.6 1.76 88.7 14.5 91611 73. 61. 0.3093 711.1 1.68 120.6 19.8 91616 87. 72. 0.2749 764.6 1.81 120.5 19.7

MEAN 74. 59. 0.2784 647.6 1.66 103.5 17.0 S.D. 7.8 7.7 0.02161 140.33 0.136 15.80 2.59 S.E. 2.2 2.2 0.00624 40.51 0.039 4.56 0.75 N 12 12 12 12 12 12 12

UNITS: MOTILITY (%), WEIGHT (GRAMS), CONCENTRATION (MILLIONS/GRAM), PRODUCTION RATE (MILLIONS/GRAM/DAY)**Page 729 of 1107**TABLE A37 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL SPERM MOTILITY AND CONCENTRATION

175 PPM SPERM PROGRESSIVE CAUDA EPID, LT TESTIS, LT PRODUCTION ANIMAL MOTILITY MOTILITY WEIGHT CONC WEIGHT CONC RATE

----------------------------------------------------------------------------------------------------------------------------------- 91565 89. 69. 0.2525 542.6 1.41 115.5 18.9 91568 71. 54. 0.2921 428.7 1.60 127.1 20.8 91570 83. 65. 0.2583 459.2 1.68 117.5 19.3 91572 82. 65. 0.2723 776.8 1.65 91.5 15.0 91580 79. 60. 0.2866 560.3 1.72 89.5 14.7 91584 76. 55. 0.2757 816.8 1.74 100.1 16.4 91587 77. 66. 0.3195 657.9 1.87 135.0 22.1 91597 79. 55. 0.2668 1006.7 1.75 110.7 18.1 91601 84. 66. 0.2826 628.2 1.59 102.9 16.9 91607 86. 71. 0.2889 418.2 1.69 111.3 18.2 91613 78. 65. 0.2233 353.0 1.56 79.8 13.1 91614 78. 62. 0.3280 503.1 1.65 85.3 14.0

MEAN 80. 63. 0.2789 596.0 1.66 105.5 17.3 S.D. 4.9 5.6 0.02832 191.92 0.115 17.04 2.79 S.E. 1.4 1.6 0.00817 55.40 0.033 4.92 0.81 N 12 12 12 12 12 12 12

UNITS: MOTILITY (%), WEIGHT (GRAMS), CONCENTRATION (MILLIONS/GRAM), PRODUCTION RATE (MILLIONS/GRAM/DAY)**Page 730 of 1107**TABLE A37 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL SPERM MOTILITY AND CONCENTRATION

10000 PPM SPERM PROGRESSIVE CAUDA EPID, LT TESTIS, LT PRODUCTION ANIMAL MOTILITY MOTILITY WEIGHT CONC WEIGHT CONC RATE

----------------------------------------------------------------------------------------------------------------------------------- 91554 79. 61. 0.2980 755.7 1.52 94.5 15.5 91557 80. 64. 0.2711 733.7 1.88 91.0 14.9 91558 76. 55. 0.2771 573.7 1.58 120.6 19.8 91571 82. 67. 0.2693 391.2 1.50 77.1 12.6 91575 81. 66. 0.2104 556.7 1.55 94.1 15.4 91600 67. 57. 0.3179 1075.2 1.72 112.9 18.5 91603 81. 70. 0.2831 735.5 1.73 95.1 15.6 91604 49. 35. 0.2876 577.7 1.71 83.6 13.7 91605 84. 65. 0.3019 226.9 1.86 98.6 16.2 91612 85. 70. 0.3086 662.0 1.86 108.6 17.8 91618 77. 59. 0.2653 558.1 1.55 98.4 16.1 91619 77. 61. 0.2584 684.2 1.62 100.9 16.5

MEAN 77. 61. 0.2791 627.5 1.67 97.9 16.1 S.D. 9.8 9.4 0.02835 207.96 0.140 12.00 1.97 S.E. 2.8 2.7 0.00819 60.03 0.040 3.46 0.57 N 12 12 12 12 12 12 12

UNITS: MOTILITY (%), WEIGHT (GRAMS), CONCENTRATION (MILLIONS/GRAM), PRODUCTION RATE (MILLIONS/GRAM/DAY) PDIVOSv4.30 01/20/2014**Page 731 of 1107**TABLE A38 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL SPERM MORPHOLOGY DIFFERENTIAL COUNTS [PERCENTAGE]

MALE GROUP: 0 PPM

----------------------------------------------------------------------------------------------------------------------------------- NORMAL HEAD HEAD MISSHAPEN MISSHAPEN FLAGELLAR HEAD/ ABSENT/ ABSENT/ HEAD/ HEAD/ DEFECTS/ SEPARATED NORMAL ABNORMAL NORMAL ABNORMAL NORMAL ANIMAL NORMAL FLAGELLUM FLAGELLUM FLAGELLUM FLAGELLUM FLAGELLUM HEAD

----------------------------------------------------------------------------------------------------------------------------------- 91555 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91560 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91562 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91563 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91564 97.5 1.5 1.0 0.0 0.0 0.0 0.0 91567 99.0 0.0 1.0 0.0 0.0 0.0 0.0 91579 94.0 5.0 1.0 0.0 0.0 0.0 0.0 91586 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91591 99.0 1.0 0.0 0.0 0.0 0.0 0.0 91592 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91609 99.5 0.5 0.0 0.0 0.0 0.0 0.0 91615 99.5 0.0 0.5 0.0 0.0 0.0 0.0

----------------------------------------------------------------------------------------------------------------------------------- MEAN 99.0 0.7 0.3 0.0 0.0 0.0 0.0 S.D. 1.75 1.45 0.45 0.00 0.00 0.00 0.00 S.E. 0.51 0.42 0.13 0.00 0.00 0.00 0.00 N 12 12 12 12 12 12 12**Page 732 of 1107**TABLE A38 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL SPERM MORPHOLOGY DIFFERENTIAL COUNTS [PERCENTAGE]

MALE GROUP: 50 PPM

----------------------------------------------------------------------------------------------------------------------------------- NORMAL HEAD HEAD MISSHAPEN MISSHAPEN FLAGELLAR HEAD/ ABSENT/ ABSENT/ HEAD/ HEAD/ DEFECTS/ SEPARATED NORMAL ABNORMAL NORMAL ABNORMAL NORMAL ANIMAL NORMAL FLAGELLUM FLAGELLUM FLAGELLUM FLAGELLUM FLAGELLUM HEAD

----------------------------------------------------------------------------------------------------------------------------------- 91556 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91559 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91561 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91566 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91576 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91582 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91585 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91589 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91593 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91594 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91595 99.5 0.5 0.0 0.0 0.0 0.0 0.0 91602 100.0 0.0 0.0 0.0 0.0 0.0 0.0

----------------------------------------------------------------------------------------------------------------------------------- MEAN 100.0 0.0 0.0 0.0 0.0 0.0 0.0 S.D. 0.14 0.14 0.00 0.00 0.00 0.00 0.00 S.E. 0.04 0.04 0.00 0.00 0.00 0.00 0.00 N 12 12 12 12 12 12 12**Page 733 of 1107**TABLE A38 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL SPERM MORPHOLOGY DIFFERENTIAL COUNTS [PERCENTAGE]

MALE GROUP: 100 PPM

----------------------------------------------------------------------------------------------------------------------------------- NORMAL HEAD HEAD MISSHAPEN MISSHAPEN FLAGELLAR HEAD/ ABSENT/ ABSENT/ HEAD/ HEAD/ DEFECTS/ SEPARATED NORMAL ABNORMAL NORMAL ABNORMAL NORMAL ANIMAL NORMAL FLAGELLUM FLAGELLUM FLAGELLUM FLAGELLUM FLAGELLUM HEAD

----------------------------------------------------------------------------------------------------------------------------------- 91569 95.5 2.5 2.0 0.0 0.0 0.0 0.0 91573 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91577 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91581 98.5 1.0 0.5 0.0 0.0 0.0 0.0 91583 98.5 0.5 1.0 0.0 0.0 0.0 0.0 91588 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91590 99.5 0.5 0.0 0.0 0.0 0.0 0.0 91598 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91599 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91608 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91611 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91616 100.0 0.0 0.0 0.0 0.0 0.0 0.0

----------------------------------------------------------------------------------------------------------------------------------- MEAN 99.3 0.4 0.3 0.0 0.0 0.0 0.0 S.D. 1.34 0.74 0.62 0.00 0.00 0.00 0.00 S.E. 0.39 0.21 0.18 0.00 0.00 0.00 0.00 N 12 12 12 12 12 12 12**Page 734 of 1107**TABLE A38 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL SPERM MORPHOLOGY DIFFERENTIAL COUNTS [PERCENTAGE]

MALE GROUP: 175 PPM

----------------------------------------------------------------------------------------------------------------------------------- NORMAL HEAD HEAD MISSHAPEN MISSHAPEN FLAGELLAR HEAD/ ABSENT/ ABSENT/ HEAD/ HEAD/ DEFECTS/ SEPARATED NORMAL ABNORMAL NORMAL ABNORMAL NORMAL ANIMAL NORMAL FLAGELLUM FLAGELLUM FLAGELLUM FLAGELLUM FLAGELLUM HEAD

----------------------------------------------------------------------------------------------------------------------------------- 91565 99.5 0.0 0.5 0.0 0.0 0.0 0.0 91568 99.5 0.0 0.5 0.0 0.0 0.0 0.0 91570 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91572 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91580 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91584 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91587 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91597 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91601 99.5 0.0 0.5 0.0 0.0 0.0 0.0 91607 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91613 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91614 100.0 0.0 0.0 0.0 0.0 0.0 0.0

----------------------------------------------------------------------------------------------------------------------------------- MEAN 99.9 0.0 0.1 0.0 0.0 0.0 0.0 S.D. 0.23 0.00 0.23 0.00 0.00 0.00 0.00 S.E. 0.07 0.00 0.07 0.00 0.00 0.00 0.00 N 12 12 12 12 12 12 12**Page 735 of 1107**TABLE A38 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL SPERM MORPHOLOGY DIFFERENTIAL COUNTS [PERCENTAGE]

MALE GROUP: 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- NORMAL HEAD HEAD MISSHAPEN MISSHAPEN FLAGELLAR HEAD/ ABSENT/ ABSENT/ HEAD/ HEAD/ DEFECTS/ SEPARATED NORMAL ABNORMAL NORMAL ABNORMAL NORMAL ANIMAL NORMAL FLAGELLUM FLAGELLUM FLAGELLUM FLAGELLUM FLAGELLUM HEAD

----------------------------------------------------------------------------------------------------------------------------------- 91554 99.5 0.5 0.0 0.0 0.0 0.0 0.0 91557 98.5 1.0 0.5 0.0 0.0 0.0 0.0 91558 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91571 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91575 98.5 0.0 1.5 0.0 0.0 0.0 0.0 91600 99.5 0.0 0.5 0.0 0.0 0.0 0.0 91603 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91604 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91605 97.5 2.0 0.5 0.0 0.0 0.0 0.0 91612 100.0 0.0 0.0 0.0 0.0 0.0 0.0 91618 99.0 0.0 1.0 0.0 0.0 0.0 0.0 91619 100.0 0.0 0.0 0.0 0.0 0.0 0.0

----------------------------------------------------------------------------------------------------------------------------------- MEAN 99.4 0.3 0.3 0.0 0.0 0.0 0.0 S.D. 0.83 0.62 0.49 0.00 0.00 0.00 0.00 S.E. 0.24 0.18 0.14 0.00 0.00 0.00 0.00 N 12 12 12 12 12 12 12

MANUALv1.0 11/14/2013 R:11/14/2013**Page 736 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91555 GROUP 1: 0 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 2.16 0.470 PAS STAIN EXAMINED LIVER 14.72 3.200 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED KIDNEYS 3.45 0.750 PAS STAIN EXAMINED SPLEEN 0.85 0.185 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED LUNGS 1.62 0.352 PAS STAIN EXAMINED TESTIS, RT 1.50 0.326 NO SIGNIFICANT TESTIS, LT 1.52 0.330 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS EPIDIDYMIS, LT 0.58 0.126 EYES HEART INTESTINE KIDNEYS CAUDA EPID, LT 0.2512 0.055 LIVER LN, MESENTERIC LUNGS PANCREAS PITUITARY 0.0178 0.004 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND EPIDIDYMIS, RT 0.59 0.128 SKIN SPLEEN STOMACH SEMINAL VESICLES CAUDA EPID, RT 0.2510 0.055 TESTIS, RT THYMUS THYROID GLANDS TRACHEA FINAL BODY WT(G) 460. URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT LUNGS PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 737 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91560 GROUP 1: 0 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 2.23 0.487 PAS STAIN EXAMINED LIVER 15.81 3.452 LUNGS MICRO: MINERALIZATION, VASCULAR 1 KIDNEYS 3.54 0.773 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED SPLEEN 0.87 0.190 PAS STAIN EXAMINED LUNGS 1.88 0.410 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED TESTIS, RT 1.70 0.371 PAS STAIN EXAMINED TESTIS, LT 1.69 0.369 NO SIGNIFICANT EPIDIDYMIS, LT 0.60 0.131 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS CAUDA EPID, LT 0.2944 0.064 EYES HEART INTESTINE KIDNEYS PITUITARY 0.0149 0.003 LIVER LN, MESENTERIC LUNGS PANCREAS EPIDIDYMIS, RT 0.64 0.140 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND CAUDA EPID, RT 0.2717 0.059 SKIN SPLEEN STOMACH SEMINAL VESICLES FINAL BODY WT(G) 458. TESTIS, RT THYMUS THYROID GLANDS TRACHEA URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 738 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91562 GROUP 1: 0 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 2.05 0.476 PAS STAIN EXAMINED LIVER 16.66 3.872 KIDNEYS GROSS: DILATED PELVIS 2 KIDNEYS 3.28 0.762 RIGHT SPLEEN 0.82 0.191 ^==> KIDNEYS: DILATATION, PELVIS LUNGS 1.40 0.325 KIDNEYS MICRO: DILATATION, PELVIS 2 TESTIS, RT 1.62 0.376 ONE KIDNEY EXAMINED TESTIS, LT 1.56 0.363 CONGESTION 3 EPIDIDYMIS, LT 0.57 0.132 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED CAUDA EPID, LT 0.2560 0.059 PAS STAIN EXAMINED PITUITARY 0.0133 0.003 URETERS MICRO: DILATATION 1 EPIDIDYMIS, RT 0.62 0.144 UNILATERAL; BOTH URETERS EXAMINED CAUDA EPID, RT 0.2690 0.063 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED FINAL BODY WT(G) 430. PAS STAIN EXAMINED NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS EYES HEART INTESTINE LIVER LN, MESENTERIC LUNGS PANCREAS PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT THYMUS THYROID GLANDS TRACHEA URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT LUNGS PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 739 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91563 GROUP 1: 0 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 2.08 0.503 PAS STAIN EXAMINED LIVER 14.49 3.503 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED KIDNEYS 3.32 0.803 PAS STAIN EXAMINED SPLEEN 0.70 0.169 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED LUNGS 1.68 0.406 PAS STAIN EXAMINED TESTIS, RT 1.67 0.404 NO SIGNIFICANT TESTIS, LT 1.65 0.399 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS EPIDIDYMIS, LT 0.55 0.133 EYES HEART INTESTINE KIDNEYS CAUDA EPID, LT 0.2791 0.067 LIVER LN, MESENTERIC LUNGS PANCREAS PITUITARY 0.0142 0.003 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND EPIDIDYMIS, RT 0.64 0.155 SKIN SPLEEN STOMACH SEMINAL VESICLES CAUDA EPID, RT 0.2878 0.070 TESTIS, RT THYMUS THYROID GLANDS TRACHEA FINAL BODY WT(G) 414. URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT LUNGS PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 740 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91564 GROUP 1: 0 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 2.10 0.495 PAS STAIN EXAMINED LIVER 14.20 3.349 LUNGS MICRO: MINERALIZATION, VASCULAR 1 KIDNEYS 3.56 0.840 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED SPLEEN 0.66 0.156 PAS STAIN EXAMINED LUNGS 1.65 0.389 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED TESTIS, RT 1.68 0.396 PAS STAIN EXAMINED TESTIS, LT 1.64 0.387 NO SIGNIFICANT EPIDIDYMIS, LT 0.56 0.132 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS CAUDA EPID, LT 0.2773 0.065 EYES HEART INTESTINE KIDNEYS PITUITARY 0.0178 0.004 LIVER LN, MESENTERIC LUNGS PANCREAS EPIDIDYMIS, RT 0.62 0.146 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND CAUDA EPID, RT 0.2677 0.063 SKIN SPLEEN STOMACH SEMINAL VESICLES FINAL BODY WT(G) 424. TESTIS, RT THYMUS THYROID GLANDS TRACHEA URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 741 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91567 GROUP 1: 0 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 1.86 0.452 PAS STAIN EXAMINED LIVER 15.57 3.787 LUNGS MICRO: ATELECTASIS 3 KIDNEYS 3.23 0.786 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED SPLEEN 0.74 0.180 PAS STAIN EXAMINED LUNGS 1.41 0.343 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED TESTIS, RT 1.59 0.387 PAS STAIN EXAMINED TESTIS, LT 1.59 0.387 NO SIGNIFICANT EPIDIDYMIS, LT 0.55 0.134 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS CAUDA EPID, LT 0.2696 0.066 EYES HEART INTESTINE KIDNEYS PITUITARY 0.0102 0.002 LIVER LN, MESENTERIC LUNGS PANCREAS EPIDIDYMIS, RT 0.62 0.151 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND CAUDA EPID, RT 0.2710 0.066 SKIN SPLEEN STOMACH SEMINAL VESICLES FINAL BODY WT(G) 411. TESTIS, RT THYMUS THYROID GLANDS TRACHEA URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 742 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91579 GROUP 1: 0 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 2.17 0.464 PAS STAIN EXAMINED LIVER 17.75 3.793 LUNGS MICRO: MINERALIZATION, VASCULAR 1 KIDNEYS 3.26 0.697 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED SPLEEN 0.90 0.192 PAS STAIN EXAMINED LUNGS 1.78 0.380 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED TESTIS, RT 1.66 0.355 PAS STAIN EXAMINED TESTIS, LT 1.66 0.355 NO SIGNIFICANT EPIDIDYMIS, LT 0.63 0.135 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS CAUDA EPID, LT 0.2849 0.061 EYES HEART INTESTINE KIDNEYS PITUITARY 0.0179 0.004 LIVER LN, MESENTERIC LUNGS PANCREAS EPIDIDYMIS, RT 0.61 0.130 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND CAUDA EPID, RT 0.2482 0.053 SKIN SPLEEN STOMACH SEMINAL VESICLES FINAL BODY WT(G) 468. TESTIS, RT THYMUS THYROID GLANDS TRACHEA URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 743 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91586 GROUP 1: 0 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 2.12 0.463 PAS STAIN EXAMINED LIVER 16.47 3.594 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED KIDNEYS 3.42 0.746 PAS STAIN EXAMINED SPLEEN 0.94 0.205 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED LUNGS 1.75 0.382 PAS STAIN EXAMINED TESTIS, RT 1.63 0.356 NO SIGNIFICANT TESTIS, LT 1.61 0.351 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS EPIDIDYMIS, LT 0.57 0.124 EYES HEART INTESTINE KIDNEYS CAUDA EPID, LT 0.2795 0.061 LIVER LN, MESENTERIC LUNGS PANCREAS PITUITARY 0.0227 0.005 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND EPIDIDYMIS, RT 0.67 0.146 SKIN SPLEEN STOMACH SEMINAL VESICLES CAUDA EPID, RT 0.2952 0.064 TESTIS, RT THYMUS THYROID GLANDS TRACHEA FINAL BODY WT(G) 458. URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT LUNGS PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 744 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91591 GROUP 1: 0 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 2.11 0.463 PAS STAIN EXAMINED LIVER 14.86 3.260 LUNGS MICRO: ATELECTASIS 3 KIDNEYS 3.35 0.735 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED SPLEEN 0.77 0.169 PAS STAIN EXAMINED LUNGS 1.75 0.384 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED TESTIS, RT 1.69 0.371 PAS STAIN EXAMINED TESTIS, LT 1.70 0.373 NO SIGNIFICANT EPIDIDYMIS, LT 0.55 0.121 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS CAUDA EPID, LT 0.2775 0.061 EYES HEART INTESTINE KIDNEYS PITUITARY 0.0136 0.003 LIVER LN, MESENTERIC LUNGS PANCREAS EPIDIDYMIS, RT 0.60 0.132 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND CAUDA EPID, RT 0.2654 0.058 SKIN SPLEEN STOMACH SEMINAL VESICLES FINAL BODY WT(G) 456. TESTIS, RT THYMUS THYROID GLANDS TRACHEA URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 745 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91592 GROUP 1: 0 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 2.28 0.450 PAS STAIN EXAMINED LIVER 17.30 3.412 LUNGS MICRO: MINERALIZATION, VASCULAR 1 KIDNEYS 3.44 0.679 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED SPLEEN 1.06 0.209 PAS STAIN EXAMINED LUNGS 1.86 0.367 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED TESTIS, RT 1.79 0.353 PAS STAIN EXAMINED TESTIS, LT 1.76 0.347 NO SIGNIFICANT EPIDIDYMIS, LT 0.63 0.124 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS CAUDA EPID, LT 0.3003 0.059 EYES HEART INTESTINE KIDNEYS PITUITARY 0.0148 0.003 LIVER LN, MESENTERIC LUNGS PANCREAS EPIDIDYMIS, RT 0.67 0.132 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND CAUDA EPID, RT 0.2779 0.055 SKIN SPLEEN STOMACH SEMINAL VESICLES FINAL BODY WT(G) 507. TESTIS, RT THYMUS THYROID GLANDS TRACHEA URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 746 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 11 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91609 GROUP 1: 0 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 2.16 0.489 PAS STAIN EXAMINED LIVER 15.38 3.480 LUNGS MICRO: MINERALIZATION, VASCULAR 1 KIDNEYS 3.52 0.796 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED SPLEEN 0.71 0.161 PAS STAIN EXAMINED LUNGS 1.44 0.326 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED TESTIS, RT 1.86 0.421 PAS STAIN EXAMINED TESTIS, LT 1.78 0.403 NO SIGNIFICANT EPIDIDYMIS, LT 0.69 0.156 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS CAUDA EPID, LT 0.3171 0.072 EYES HEART INTESTINE KIDNEYS PITUITARY 0.0145 0.003 LIVER LN, MESENTERIC LUNGS PANCREAS EPIDIDYMIS, RT 0.72 0.163 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND CAUDA EPID, RT 0.3076 0.070 SKIN SPLEEN STOMACH SEMINAL VESICLES FINAL BODY WT(G) 442. TESTIS, RT THYMUS THYROID GLANDS TRACHEA URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 747 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 12 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91615 GROUP 1: 0 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 2.15 0.459 PAS STAIN EXAMINED LIVER 16.54 3.530 LUNGS MICRO: ATELECTASIS 3 KIDNEYS 3.26 0.696 POST-TERMINAL SPLEEN 0.79 0.169 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED LUNGS 1.68 0.359 PAS STAIN EXAMINED TESTIS, RT 1.63 0.348 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED TESTIS, LT 1.64 0.350 PAS STAIN EXAMINED EPIDIDYMIS, LT 0.60 0.128 NO SIGNIFICANT CAUDA EPID, LT 0.3024 0.065 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS PITUITARY 0.0159 0.003 EYES HEART INTESTINE KIDNEYS EPIDIDYMIS, RT 0.66 0.141 LIVER LN, MESENTERIC LUNGS PANCREAS CAUDA EPID, RT 0.2768 0.059 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND FINAL BODY WT(G) 469. SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT THYMUS THYROID GLANDS TRACHEA URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 748 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 13 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91556 GROUP 2: 50 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT BRAIN 1.94 0.434 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS LIVER 14.68 3.284 EYES HEART INTESTINE KIDNEYS KIDNEYS 3.07 0.687 LIVER LN, MESENTERIC LUNGS PANCREAS SPLEEN 0.67 0.150 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND LUNGS 1.57 0.351 SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT 1.68 0.376 TESTIS, RT THYMUS THYROID GLANDS TRACHEA TESTIS, LT 1.67 0.374 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT 0.64 0.143 EPIDIDYMIS, LT VAS DEFERENS CAUDA EPID, LT 0.2826 0.063 PITUITARY 0.0126 0.003 EPIDIDYMIS, RT 0.68 0.152 CAUDA EPID, RT 0.2840 0.064 FINAL BODY WT(G) 447.

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 749 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 14 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91559 GROUP 2: 50 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT BRAIN 1.95 0.456 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS LIVER 16.22 3.790 EYES HEART INTESTINE KIDNEYS KIDNEYS 3.46 0.808 LIVER LN, MESENTERIC LUNGS PANCREAS SPLEEN 0.85 0.199 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND LUNGS 1.89 0.442 SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT 1.77 0.414 TESTIS, RT THYMUS THYROID GLANDS TRACHEA TESTIS, LT 1.79 0.418 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT 0.59 0.138 EPIDIDYMIS, LT VAS DEFERENS CAUDA EPID, LT 0.2970 0.069 PITUITARY 0.0143 0.003 EPIDIDYMIS, RT 0.62 0.145 CAUDA EPID, RT 0.2438 0.057 FINAL BODY WT(G) 428.

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 750 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 15 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91561 GROUP 2: 50 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT BRAIN 2.09 0.459 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS LIVER 16.27 3.575 EYES HEART INTESTINE KIDNEYS KIDNEYS 3.46 0.760 LIVER LN, MESENTERIC LUNGS PANCREAS SPLEEN 0.86 0.189 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND LUNGS 1.80 0.396 SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT 1.68 0.369 TESTIS, RT THYMUS THYROID GLANDS TRACHEA TESTIS, LT 1.61 0.354 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT 0.68 0.149 EPIDIDYMIS, LT VAS DEFERENS CAUDA EPID, LT 0.3222 0.071 PITUITARY 0.0176 0.004 EPIDIDYMIS, RT 0.69 0.152 CAUDA EPID, RT 0.3183 0.070 FINAL BODY WT(G) 455.

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 751 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 16 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91566 GROUP 2: 50 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT BRAIN 1.87 0.437 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS LIVER 14.61 3.411 EYES HEART INTESTINE KIDNEYS KIDNEYS 3.24 0.756 LIVER LN, MESENTERIC LUNGS PANCREAS SPLEEN 0.72 0.168 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND LUNGS 1.48 0.346 SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT 1.71 0.399 TESTIS, RT THYMUS THYROID GLANDS TRACHEA TESTIS, LT 1.73 0.404 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT 0.61 0.142 EPIDIDYMIS, LT VAS DEFERENS CAUDA EPID, LT 0.2596 0.061 PITUITARY 0.0120 0.003 EPIDIDYMIS, RT 0.67 0.156 CAUDA EPID, RT 0.2544 0.059 FINAL BODY WT(G) 428.

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 752 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 17 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91576 GROUP 2: 50 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT BRAIN 2.09 0.506 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS LIVER 14.82 3.587 EYES HEART INTESTINE KIDNEYS KIDNEYS 3.37 0.816 LIVER LN, MESENTERIC LUNGS PANCREAS SPLEEN 0.79 0.191 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND LUNGS 1.42 0.344 SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT 1.66 0.402 TESTIS, RT THYMUS THYROID GLANDS TRACHEA TESTIS, LT 1.67 0.404 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT 0.60 0.145 EPIDIDYMIS, LT VAS DEFERENS CAUDA EPID, LT 0.2934 0.071 PITUITARY 0.0134 0.003 EPIDIDYMIS, RT 0.64 0.155 CAUDA EPID, RT 0.3055 0.074 FINAL BODY WT(G) 413.

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 753 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 18 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91582 GROUP 2: 50 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT BRAIN 2.14 0.417 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS LIVER 18.93 3.690 EYES HEART INTESTINE KIDNEYS KIDNEYS 3.94 0.768 LIVER LN, MESENTERIC LUNGS PANCREAS SPLEEN 1.01 0.197 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND LUNGS 1.70 0.331 SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT 1.94 0.378 TESTIS, RT THYMUS THYROID GLANDS TRACHEA TESTIS, LT 1.90 0.370 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT 0.64 0.125 EPIDIDYMIS, LT VAS DEFERENS CAUDA EPID, LT 0.3067 0.060 PITUITARY 0.0162 0.003 EPIDIDYMIS, RT 0.70 0.136 CAUDA EPID, RT 0.2774 0.054 FINAL BODY WT(G) 513.

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 754 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 19 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91585 GROUP 2: 50 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT BRAIN 2.04 0.408 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS LIVER 21.23 4.246 EYES HEART INTESTINE KIDNEYS KIDNEYS 3.98 0.796 LIVER LN, MESENTERIC LUNGS PANCREAS SPLEEN 1.04 0.208 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND LUNGS 1.79 0.358 SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT 1.67 0.334 TESTIS, RT THYMUS THYROID GLANDS TRACHEA TESTIS, LT 1.72 0.344 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT 0.67 0.134 EPIDIDYMIS, LT VAS DEFERENS CAUDA EPID, LT 0.2929 0.059 PITUITARY 0.0174 0.003 EPIDIDYMIS, RT 0.69 0.138 CAUDA EPID, RT 0.2850 0.057 FINAL BODY WT(G) 500.

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 755 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 20 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91589 GROUP 2: 50 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT BRAIN 2.02 0.486 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS LIVER 13.44 3.232 EYES HEART INTESTINE KIDNEYS KIDNEYS 2.92 0.702 LIVER LN, MESENTERIC LUNGS PANCREAS SPLEEN 0.69 0.166 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND LUNGS 1.72 0.414 SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT 1.60 0.385 TESTIS, RT THYMUS THYROID GLANDS TRACHEA TESTIS, LT 1.53 0.368 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT 0.54 0.130 EPIDIDYMIS, LT VAS DEFERENS CAUDA EPID, LT 0.2590 0.062 PITUITARY 0.0129 0.003 EPIDIDYMIS, RT 0.57 0.137 CAUDA EPID, RT 0.2568 0.062 FINAL BODY WT(G) 416.

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 756 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 21 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91593 GROUP 2: 50 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT BRAIN 2.17 0.476 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS LIVER 16.35 3.589 EYES HEART INTESTINE KIDNEYS KIDNEYS 3.49 0.766 LIVER LN, MESENTERIC LUNGS PANCREAS SPLEEN 0.96 0.211 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND LUNGS 1.63 0.358 SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT 1.41 0.309 TESTIS, RT THYMUS THYROID GLANDS TRACHEA TESTIS, LT 1.47 0.323 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT 0.55 0.121 EPIDIDYMIS, LT VAS DEFERENS CAUDA EPID, LT 0.2649 0.058 PITUITARY 0.0165 0.004 EPIDIDYMIS, RT 0.61 0.134 CAUDA EPID, RT 0.2732 0.060 FINAL BODY WT(G) 456.

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 757 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 22 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91594 GROUP 2: 50 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT BRAIN 2.07 0.458 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS LIVER 16.00 3.543 EYES HEART INTESTINE KIDNEYS KIDNEYS 2.98 0.660 LIVER LN, MESENTERIC LUNGS PANCREAS SPLEEN 0.74 0.164 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND LUNGS 2.02 0.447 SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT 1.67 0.370 TESTIS, RT THYMUS THYROID GLANDS TRACHEA TESTIS, LT 1.62 0.359 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT 0.58 0.128 EPIDIDYMIS, LT VAS DEFERENS CAUDA EPID, LT 0.3126 0.069 PITUITARY 0.0153 0.003 EPIDIDYMIS, RT 0.60 0.133 CAUDA EPID, RT 0.2789 0.062 FINAL BODY WT(G) 452.

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 758 of 1107**TABLE A39 (F0 MALES)

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ANIMAL NO. 91595 GROUP 2: 50 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. KIDNEYS GROSS: DILATED PELVIS 2 BRAIN 2.19 0.458 RIGHT LIVER 17.08 3.573 ^==> KIDNEYS: DILATATION, PELVIS KIDNEYS 3.04 0.636 KIDNEYS MICRO: DILATATION, PELVIS 2 SPLEEN 0.92 0.192 ONE KIDNEY EXAMINED LUNGS 1.82 0.381 URETERS MICRO: DILATATION 1 TESTIS, RT 1.66 0.347 ONE OF PAIR PRESENT TESTIS, LT 1.70 0.356 NO SIGNIFICANT EPIDIDYMIS, LT 0.67 0.140 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS CAUDA EPID, LT 0.3439 0.072 EYES HEART INTESTINE LIVER PITUITARY 0.0146 0.003 LN, MESENTERIC LUNGS PANCREAS PITUITARY EPIDIDYMIS, RT 0.71 0.149 PROSTATE SPINAL CORD SAL. GLAND MAND SKIN CAUDA EPID, RT 0.3060 0.064 SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT FINAL BODY WT(G) 478. THYMUS THYROID GLANDS TRACHEA URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 759 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 24 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91602 GROUP 2: 50 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT BRAIN 1.89 0.392 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS LIVER 16.87 3.500 EYES HEART INTESTINE KIDNEYS KIDNEYS 3.65 0.757 LIVER LN, MESENTERIC LUNGS PANCREAS SPLEEN 0.79 0.164 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND LUNGS 1.70 0.353 SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT 1.80 0.373 TESTIS, RT THYMUS THYROID GLANDS TRACHEA TESTIS, LT 1.81 0.376 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT 0.62 0.129 EPIDIDYMIS, LT VAS DEFERENS CAUDA EPID, LT 0.3050 0.063 PITUITARY 0.0120 0.002 EPIDIDYMIS, RT 0.65 0.135 CAUDA EPID, RT 0.3072 0.064 FINAL BODY WT(G) 482.

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 760 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 25 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91569 GROUP 3: 100 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT BRAIN 2.06 0.479 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS LIVER 14.10 3.279 EYES HEART INTESTINE KIDNEYS KIDNEYS 2.81 0.653 LIVER LN, MESENTERIC LUNGS PANCREAS SPLEEN 0.89 0.207 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND LUNGS 1.60 0.372 SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT 1.61 0.374 TESTIS, RT THYMUS THYROID GLANDS TRACHEA TESTIS, LT 1.48 0.344 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT 0.54 0.126 EPIDIDYMIS, LT VAS DEFERENS CAUDA EPID, LT 0.2398 0.056 PITUITARY 0.0103 0.002 EPIDIDYMIS, RT 0.56 0.130 CAUDA EPID, RT 0.2163 0.050 FINAL BODY WT(G) 430.

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 761 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 26 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91573 GROUP 3: 100 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT MICRO: NOT EXAMINED PER WIL SOP P BRAIN 2.16 0.522 SKIN GROSS: MATTING, RED P LIVER 15.39 3.718 OCULAR, BILATERAL KIDNEYS 3.27 0.790 ^==> GENERAL COMMENT: NOT EXAMINED PER WIL SOP SPLEEN 0.75 0.181 TEETH GROSS: MALALIGNED P LUNGS 1.47 0.355 UPPER INCISOR, BILATERAL; CEO MALALIGNED TESTIS, RT 1.86 0.449 ^==> GENERAL COMMENT: NOT EXAMINED PER WIL SOP TESTIS, LT 1.86 0.449 NO SIGNIFICANT EPIDIDYMIS, LT 0.65 0.157 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS CAUDA EPID, LT 0.2993 0.072 EYES HEART INTESTINE KIDNEYS PITUITARY 0.0134 0.003 LIVER LN, MESENTERIC LUNGS PANCREAS EPIDIDYMIS, RT 0.73 0.176 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND CAUDA EPID, RT 0.3138 0.076 SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT FINAL BODY WT(G) 414. THYMUS THYROID GLANDS TRACHEA URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 762 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 27 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91577 GROUP 3: 100 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT BRAIN 2.02 0.494 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS LIVER 14.70 3.594 EYES HEART INTESTINE KIDNEYS KIDNEYS 3.19 0.780 LIVER LN, MESENTERIC LUNGS PANCREAS SPLEEN 0.68 0.166 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND LUNGS 1.84 0.450 SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT 1.55 0.379 TESTIS, RT THYMUS THYROID GLANDS TRACHEA TESTIS, LT 1.57 0.384 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT 0.53 0.130 EPIDIDYMIS, LT VAS DEFERENS CAUDA EPID, LT 0.2611 0.064 PITUITARY 0.0105 0.003 EPIDIDYMIS, RT 0.57 0.139 CAUDA EPID, RT 0.2454 0.060 FINAL BODY WT(G) 409.

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 763 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 28 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91581 GROUP 3: 100 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT BRAIN 2.07 0.471 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS LIVER 15.67 3.569 EYES HEART INTESTINE KIDNEYS KIDNEYS 3.32 0.756 LIVER LN, MESENTERIC LUNGS PANCREAS SPLEEN 0.72 0.164 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND LUNGS 1.78 0.405 SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT 1.63 0.371 TESTIS, RT THYMUS THYROID GLANDS TRACHEA TESTIS, LT 1.59 0.362 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT 0.59 0.134 EPIDIDYMIS, LT VAS DEFERENS CAUDA EPID, LT 0.3040 0.069 PITUITARY 0.0125 0.003 EPIDIDYMIS, RT 0.64 0.146 CAUDA EPID, RT 0.2767 0.063 FINAL BODY WT(G) 439.

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 764 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 29 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91583 GROUP 3: 100 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT BRAIN 2.02 0.497 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS LIVER 14.21 3.495 EYES HEART INTESTINE KIDNEYS KIDNEYS 2.97 0.730 LIVER LN, MESENTERIC LUNGS PANCREAS SPLEEN 0.75 0.184 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND LUNGS 1.71 0.421 SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT 1.75 0.430 TESTIS, RT THYMUS THYROID GLANDS TRACHEA TESTIS, LT 1.74 0.428 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT 0.61 0.150 EPIDIDYMIS, LT VAS DEFERENS CAUDA EPID, LT 0.2789 0.069 PITUITARY 0.0119 0.003 EPIDIDYMIS, RT 0.66 0.162 CAUDA EPID, RT 0.2743 0.067 FINAL BODY WT(G) 407.

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 765 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 30 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91588 GROUP 3: 100 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT BRAIN 1.99 0.439 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS LIVER 17.58 3.881 EYES HEART INTESTINE KIDNEYS KIDNEYS 3.60 0.795 LIVER LN, MESENTERIC LUNGS PANCREAS SPLEEN 0.71 0.157 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND LUNGS 1.66 0.366 SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT 1.85 0.408 TESTIS, RT THYMUS THYROID GLANDS TRACHEA TESTIS, LT 1.85 0.408 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT 0.63 0.139 EPIDIDYMIS, LT VAS DEFERENS CAUDA EPID, LT 0.2997 0.066 PITUITARY 0.0125 0.003 EPIDIDYMIS, RT 0.64 0.141 CAUDA EPID, RT 0.3015 0.067 FINAL BODY WT(G) 453.

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 766 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 31 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91590 GROUP 3: 100 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT BRAIN 2.18 0.487 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS LIVER 15.06 3.365 EYES HEART INTESTINE KIDNEYS KIDNEYS 3.15 0.704 LIVER LN, MESENTERIC LUNGS PANCREAS SPLEEN 0.80 0.179 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND LUNGS 1.61 0.360 SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT 1.54 0.344 TESTIS, RT THYMUS THYROID GLANDS TRACHEA TESTIS, LT 1.55 0.346 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT 0.57 0.127 EPIDIDYMIS, LT VAS DEFERENS CAUDA EPID, LT 0.2844 0.064 PITUITARY 0.0151 0.003 EPIDIDYMIS, RT 0.63 0.141 CAUDA EPID, RT 0.2792 0.062 FINAL BODY WT(G) 448.

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 767 of 1107**TABLE A39 (F0 MALES)

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ANIMAL NO. 91598 GROUP 3: 100 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT BRAIN 1.97 0.478 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS LIVER 14.00 3.398 EYES HEART INTESTINE KIDNEYS KIDNEYS 3.45 0.837 LIVER LN, MESENTERIC LUNGS PANCREAS SPLEEN 0.74 0.180 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND LUNGS 1.74 0.422 SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT 1.54 0.374 TESTIS, RT THYMUS THYROID GLANDS TRACHEA TESTIS, LT 1.55 0.376 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT 0.57 0.138 EPIDIDYMIS, LT VAS DEFERENS CAUDA EPID, LT 0.2715 0.066 PITUITARY 0.0136 0.003 EPIDIDYMIS, RT 0.59 0.143 CAUDA EPID, RT 0.2539 0.062 FINAL BODY WT(G) 412.

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 768 of 1107**TABLE A39 (F0 MALES)

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ANIMAL NO. 91599 GROUP 3: 100 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT BRAIN 2.02 0.486 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS LIVER 15.92 3.829 EYES HEART INTESTINE KIDNEYS KIDNEYS 3.13 0.753 LIVER LN, MESENTERIC LUNGS PANCREAS SPLEEN 0.77 0.185 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND LUNGS 1.64 0.394 SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT 1.52 0.366 TESTIS, RT THYMUS THYROID GLANDS TRACHEA TESTIS, LT 1.52 0.366 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT 0.56 0.135 EPIDIDYMIS, LT VAS DEFERENS CAUDA EPID, LT 0.2566 0.062 PITUITARY 0.0123 0.003 EPIDIDYMIS, RT 0.60 0.144 CAUDA EPID, RT 0.2632 0.063 FINAL BODY WT(G) 416.

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 769 of 1107**TABLE A39 (F0 MALES)

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ANIMAL NO. 91608 GROUP 3: 100 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT BRAIN 2.03 0.456 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS LIVER 14.49 3.256 EYES HEART INTESTINE KIDNEYS KIDNEYS 3.35 0.753 LIVER LN, MESENTERIC LUNGS PANCREAS SPLEEN 0.79 0.178 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND LUNGS 1.80 0.404 SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT 1.75 0.393 TESTIS, RT THYMUS THYROID GLANDS TRACHEA TESTIS, LT 1.76 0.396 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT 0.57 0.128 EPIDIDYMIS, LT VAS DEFERENS CAUDA EPID, LT 0.2618 0.059 PITUITARY 0.0117 0.003 EPIDIDYMIS, RT 0.64 0.144 CAUDA EPID, RT 0.2603 0.058 FINAL BODY WT(G) 445.

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 770 of 1107**TABLE A39 (F0 MALES)

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ANIMAL NO. 91611 GROUP 3: 100 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT BRAIN 1.95 0.442 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS LIVER 15.63 3.547 EYES HEART INTESTINE KIDNEYS KIDNEYS 3.35 0.760 LIVER LN, MESENTERIC LUNGS PANCREAS SPLEEN 0.74 0.168 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND LUNGS 1.67 0.379 SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT 1.70 0.386 TESTIS, RT THYMUS THYROID GLANDS TRACHEA TESTIS, LT 1.68 0.381 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT 0.66 0.150 EPIDIDYMIS, LT VAS DEFERENS CAUDA EPID, LT 0.3093 0.070 PITUITARY 0.0130 0.003 EPIDIDYMIS, RT 0.66 0.150 CAUDA EPID, RT 0.2551 0.058 FINAL BODY WT(G) 441.

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 771 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 36 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91616 GROUP 3: 100 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT BRAIN 2.07 0.456 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS LIVER 16.80 3.700 EYES HEART INTESTINE KIDNEYS KIDNEYS 3.33 0.733 LIVER LN, MESENTERIC LUNGS PANCREAS SPLEEN 0.78 0.172 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND LUNGS 1.74 0.383 SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT 1.76 0.388 TESTIS, RT THYMUS THYROID GLANDS TRACHEA TESTIS, LT 1.81 0.399 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT 0.58 0.128 EPIDIDYMIS, LT VAS DEFERENS CAUDA EPID, LT 0.2749 0.061 PITUITARY 0.0141 0.003 EPIDIDYMIS, RT 0.66 0.145 CAUDA EPID, RT 0.2745 0.060 FINAL BODY WT(G) 454.

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 772 of 1107**TABLE A39 (F0 MALES)

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ANIMAL NO. 91565 GROUP 4: 175 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 2.06 0.505 PAS STAIN EXAMINED LIVER 14.18 3.475 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED KIDNEYS 2.94 0.721 PAS STAIN EXAMINED SPLEEN 0.68 0.167 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED LUNGS 1.67 0.409 PAS STAIN EXAMINED TESTIS, RT 1.47 0.360 NO SIGNIFICANT TESTIS, LT 1.41 0.346 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS EPIDIDYMIS, LT 0.53 0.130 EYES HEART INTESTINE KIDNEYS CAUDA EPID, LT 0.2525 0.062 LIVER LN, MESENTERIC LUNGS PANCREAS PITUITARY 0.0106 0.003 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND EPIDIDYMIS, RT 0.59 0.145 SKIN SPLEEN STOMACH SEMINAL VESICLES CAUDA EPID, RT 0.2524 0.062 TESTIS, RT THYMUS THYROID GLANDS TRACHEA FINAL BODY WT(G) 408. URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT LUNGS PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 773 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 38 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91568 GROUP 4: 175 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 1.99 0.454 PAS STAIN EXAMINED LIVER 16.32 3.719 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED KIDNEYS 3.81 0.868 PAS STAIN EXAMINED SPLEEN 0.68 0.155 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED LUNGS 1.70 0.387 PAS STAIN EXAMINED TESTIS, RT 1.63 0.371 NO SIGNIFICANT TESTIS, LT 1.60 0.365 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS EPIDIDYMIS, LT 0.62 0.141 EYES HEART INTESTINE KIDNEYS CAUDA EPID, LT 0.2921 0.067 LIVER LN, MESENTERIC LUNGS PANCREAS PITUITARY 0.0140 0.003 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND EPIDIDYMIS, RT 0.62 0.141 SKIN SPLEEN STOMACH SEMINAL VESICLES CAUDA EPID, RT 0.2490 0.057 TESTIS, RT THYMUS THYROID GLANDS TRACHEA FINAL BODY WT(G) 439. URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT LUNGS PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 774 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 39 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91570 GROUP 4: 175 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 1.91 0.450 PAS STAIN EXAMINED LIVER 14.48 3.409 KIDNEYS GROSS: AREA(S), DEPRESSED P KIDNEYS 3.20 0.753 FEW, PINPOINT, IN CORTEX, BILATERAL SPLEEN 0.86 0.202 ^==> KIDNEYS: INDENTATION, CAPSULAR LUNGS 1.67 0.393 KIDNEYS MICRO: INDENTATION, CAPSULAR 2 TESTIS, RT 1.64 0.386 FOCAL TESTIS, LT 1.68 0.395 LUNGS MICRO: ATELECTASIS 3 EPIDIDYMIS, LT 0.61 0.144 PROSTATE MICRO: INFLAMMATION, SUBACUTE 1 CAUDA EPID, LT 0.2583 0.061 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED PITUITARY 0.0124 0.003 PAS STAIN EXAMINED EPIDIDYMIS, RT 0.64 0.151 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED CAUDA EPID, RT 0.2848 0.067 PAS STAIN EXAMINED FINAL BODY WT(G) 425. NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS EYES HEART INTESTINE LIVER LN, MESENTERIC LUNGS PANCREAS PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT THYMUS THYROID GLANDS TRACHEA URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT PITUITARY SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 775 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 40 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91572 GROUP 4: 175 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 2.09 0.489 PAS STAIN EXAMINED LIVER 16.20 3.794 LUNGS MICRO: ATELECTASIS 3 KIDNEYS 3.26 0.763 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED SPLEEN 0.83 0.194 PAS STAIN EXAMINED LUNGS 1.91 0.447 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED TESTIS, RT 1.71 0.400 PAS STAIN EXAMINED TESTIS, LT 1.65 0.386 NO SIGNIFICANT EPIDIDYMIS, LT 0.60 0.141 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS CAUDA EPID, LT 0.2723 0.064 EYES HEART INTESTINE KIDNEYS PITUITARY 0.0121 0.003 LIVER LN, MESENTERIC LUNGS PANCREAS EPIDIDYMIS, RT 0.63 0.148 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND CAUDA EPID, RT 0.2798 0.066 SKIN SPLEEN STOMACH SEMINAL VESICLES FINAL BODY WT(G) 427. TESTIS, RT THYMUS THYROID GLANDS TRACHEA URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 776 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 41 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91580 GROUP 4: 175 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 2.00 0.483 PAS STAIN EXAMINED LIVER 14.26 3.444 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED KIDNEYS 3.32 0.802 PAS STAIN EXAMINED SPLEEN 0.60 0.145 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED LUNGS 1.87 0.452 PAS STAIN EXAMINED TESTIS, RT 1.71 0.413 NO SIGNIFICANT TESTIS, LT 1.72 0.415 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS EPIDIDYMIS, LT 0.58 0.140 EYES HEART INTESTINE KIDNEYS CAUDA EPID, LT 0.2866 0.069 LIVER LN, MESENTERIC LUNGS PANCREAS PITUITARY 0.0126 0.003 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND EPIDIDYMIS, RT 0.56 0.135 SKIN SPLEEN STOMACH SEMINAL VESICLES CAUDA EPID, RT 0.2404 0.058 TESTIS, RT THYMUS THYROID GLANDS TRACHEA FINAL BODY WT(G) 414. URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT LUNGS PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 777 of 1107**TABLE A39 (F0 MALES)

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ANIMAL NO. 91584 GROUP 4: 175 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 2.02 0.473 PAS STAIN EXAMINED LIVER 15.90 3.726 LUNGS MICRO: INFLAMMATION, SUBACUTE 1 KIDNEYS 3.19 0.748 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED SPLEEN 0.73 0.171 PAS STAIN EXAMINED LUNGS 1.73 0.405 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED TESTIS, RT 1.74 0.408 PAS STAIN EXAMINED TESTIS, LT 1.74 0.408 NO SIGNIFICANT EPIDIDYMIS, LT 0.66 0.155 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS CAUDA EPID, LT 0.2757 0.065 EYES HEART INTESTINE KIDNEYS PITUITARY 0.0138 0.003 LIVER LN, MESENTERIC LUNGS PANCREAS EPIDIDYMIS, RT 0.62 0.145 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND CAUDA EPID, RT 0.2533 0.059 SKIN SPLEEN STOMACH SEMINAL VESICLES FINAL BODY WT(G) 427. TESTIS, RT THYMUS THYROID GLANDS TRACHEA URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 778 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 43 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91587 GROUP 4: 175 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 2.03 0.430 PAS STAIN EXAMINED LIVER 17.64 3.737 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED KIDNEYS 3.65 0.773 PAS STAIN EXAMINED SPLEEN 0.99 0.210 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED LUNGS 2.01 0.426 PAS STAIN EXAMINED TESTIS, RT 1.90 0.403 NO SIGNIFICANT TESTIS, LT 1.87 0.396 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS EPIDIDYMIS, LT 0.66 0.140 EYES HEART INTESTINE KIDNEYS CAUDA EPID, LT 0.3195 0.068 LIVER LN, MESENTERIC LUNGS PANCREAS PITUITARY 0.0135 0.003 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND EPIDIDYMIS, RT 0.66 0.140 SKIN SPLEEN STOMACH SEMINAL VESICLES CAUDA EPID, RT 0.2723 0.058 TESTIS, RT THYMUS THYROID GLANDS TRACHEA FINAL BODY WT(G) 472. URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT LUNGS PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 779 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 44 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91597 GROUP 4: 175 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 1.91 0.449 PAS STAIN EXAMINED LIVER 14.18 3.336 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED KIDNEYS 3.31 0.779 PAS STAIN EXAMINED SPLEEN 0.77 0.181 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED LUNGS 2.01 0.473 PAS STAIN EXAMINED TESTIS, RT 1.74 0.409 NO SIGNIFICANT TESTIS, LT 1.75 0.412 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS EPIDIDYMIS, LT 0.59 0.139 EYES HEART INTESTINE KIDNEYS CAUDA EPID, LT 0.2668 0.063 LIVER LN, MESENTERIC LUNGS PANCREAS PITUITARY 0.0113 0.003 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND EPIDIDYMIS, RT 0.66 0.155 SKIN SPLEEN STOMACH SEMINAL VESICLES CAUDA EPID, RT 0.2745 0.065 TESTIS, RT THYMUS THYROID GLANDS TRACHEA FINAL BODY WT(G) 425. URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT LUNGS PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 780 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 45 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91601 GROUP 4: 175 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 2.04 0.475 PAS STAIN EXAMINED LIVER 15.22 3.540 LUNGS MICRO: MINERALIZATION, VASCULAR 1 KIDNEYS 3.32 0.772 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED SPLEEN 0.84 0.195 PAS STAIN EXAMINED LUNGS 1.61 0.375 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED TESTIS, RT 1.62 0.377 PAS STAIN EXAMINED TESTIS, LT 1.59 0.370 NO SIGNIFICANT EPIDIDYMIS, LT 0.60 0.140 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS CAUDA EPID, LT 0.2826 0.066 EYES HEART INTESTINE KIDNEYS PITUITARY 0.0119 0.003 LIVER LN, MESENTERIC LUNGS PANCREAS EPIDIDYMIS, RT 0.62 0.144 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND CAUDA EPID, RT 0.2693 0.063 SKIN SPLEEN STOMACH SEMINAL VESICLES FINAL BODY WT(G) 430. TESTIS, RT THYMUS THYROID GLANDS TRACHEA URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 781 of 1107**TABLE A39 (F0 MALES)

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ANIMAL NO. 91607 GROUP 4: 175 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 2.17 0.464 PAS STAIN EXAMINED LIVER 16.16 3.452 SPLEEN GROSS: AREA(S), WHITE P KIDNEYS 3.16 0.675 MULTIPLE, 1 TO 6 MM IN DIAMETER SPLEEN 0.86 0.184 ^==> SPLEEN: FIBROSIS, CAPSULAR LUNGS 1.85 0.395 SPLEEN MICRO: INFLAMMATION, CHRONIC 2 TESTIS, RT 1.79 0.382 FOCAL WITHIN RED PULP ADJACENT TO CAPSULE TESTIS, LT 1.69 0.361 FIBROSIS, CAPSULAR 2 EPIDIDYMIS, LT 0.62 0.132 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED CAUDA EPID, LT 0.2889 0.062 PAS STAIN EXAMINED PITUITARY 0.0132 0.003 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED EPIDIDYMIS, RT 0.71 0.152 PAS STAIN EXAMINED CAUDA EPID, RT 0.2990 0.064 NO SIGNIFICANT FINAL BODY WT(G) 468. CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS PANCREAS PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND SKIN STOMACH SEMINAL VESICLES TESTIS, RT THYMUS THYROID GLANDS TRACHEA URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT LUNGS PITUITARY PROSTATE SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 782 of 1107**TABLE A39 (F0 MALES)

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ANIMAL NO. 91613 GROUP 4: 175 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 1.99 0.441 PAS STAIN EXAMINED LIVER 15.45 3.426 LUNGS MICRO: MINERALIZATION, VASCULAR 2 KIDNEYS 3.22 0.714 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED SPLEEN 0.77 0.171 PAS STAIN EXAMINED LUNGS 2.01 0.446 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED TESTIS, RT 1.56 0.346 PAS STAIN EXAMINED TESTIS, LT 1.56 0.346 NO SIGNIFICANT EPIDIDYMIS, LT 0.56 0.124 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS CAUDA EPID, LT 0.2233 0.050 EYES HEART INTESTINE KIDNEYS PITUITARY 0.0144 0.003 LIVER LN, MESENTERIC LUNGS PANCREAS EPIDIDYMIS, RT 0.61 0.135 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND CAUDA EPID, RT 0.2292 0.051 SKIN SPLEEN STOMACH SEMINAL VESICLES FINAL BODY WT(G) 451. TESTIS, RT THYMUS THYROID GLANDS TRACHEA URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 783 of 1107**TABLE A39 (F0 MALES)

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ANIMAL NO. 91614 GROUP 4: 175 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 1.97 0.425 PAS STAIN EXAMINED LIVER 16.89 3.640 PITUITARY MICRO: NO SIGNIFICANT CHANGES OBSERVED KIDNEYS 3.74 0.806 PARS DISTALIS ONLY SPLEEN 0.67 0.144 PROSTATE MICRO: INFLAMMATION, SUBACUTE 2 LUNGS 1.57 0.338 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED TESTIS, RT 1.71 0.369 PAS STAIN EXAMINED TESTIS, LT 1.65 0.356 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED EPIDIDYMIS, LT 0.68 0.147 PAS STAIN EXAMINED CAUDA EPID, LT 0.3280 0.071 NO SIGNIFICANT PITUITARY 0.0128 0.003 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS EPIDIDYMIS, RT 0.71 0.153 EYES HEART INTESTINE KIDNEYS CAUDA EPID, RT 0.3102 0.067 LIVER LN, MESENTERIC LUNGS PANCREAS FINAL BODY WT(G) 464. PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT THYMUS THYROID GLANDS TRACHEA URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT LUNGS PITUITARY SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 784 of 1107**TABLE A39 (F0 MALES)

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ANIMAL NO. 91554 GROUP 5: 10000 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 1.97 0.477 PAS STAIN EXAMINED LIVER 12.74 3.083 LUNGS MICRO: ATELECTASIS 2 KIDNEYS 2.51 0.607 HEMORRHAGE 2 SPLEEN 0.74 0.179 PER-ACUTE LUNGS 1.53 0.370 PROSTATE MICRO: NO SIGNIFICANT CHANGES OBSERVED TESTIS, RT 1.62 0.392 MILD INTERSTITIAL EDEMA TESTIS, LT 1.52 0.368 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED EPIDIDYMIS, LT 0.63 0.152 PAS STAIN EXAMINED; MILD INTERSTITIAL EDEMA CAUDA EPID, LT 0.2980 0.072 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED PITUITARY 0.0130 0.003 PAS STAIN EXAMINED EPIDIDYMIS, RT 0.57 0.138 LN, MANDIBULAR GROSS: ENLARGED P CAUDA EPID, RT 0.2265 0.055 BILATERAL FINAL BODY WT(G) 413. ^==> LN, MANDIBULAR: HYPERPLASIA, LYMPHOID LN, MANDIBULAR MICRO: HYPERPLASIA, LYMPHOID 3 BILATERAL, PARACORTICAL MOSTLY NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS PANCREAS PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT THYMUS THYROID GLANDS TRACHEA URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN**Page 785 of 1107**TABLE A39 (F0 MALES)

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ANIMAL NO. 91554 GROUP 5: 10000 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 786 of 1107**TABLE A39 (F0 MALES)

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ANIMAL NO. 91557 GROUP 5: 10000 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 2.15 0.469 PAS STAIN EXAMINED LIVER 14.88 3.245 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED KIDNEYS 3.30 0.720 PAS STAIN EXAMINED SPLEEN 0.95 0.207 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED LUNGS 1.91 0.417 PAS STAIN EXAMINED TESTIS, RT 1.87 0.408 NO SIGNIFICANT TESTIS, LT 1.88 0.410 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS EPIDIDYMIS, LT 0.62 0.135 EYES HEART INTESTINE KIDNEYS CAUDA EPID, LT 0.2711 0.059 LIVER LN, MESENTERIC LUNGS PANCREAS PITUITARY 0.0159 0.003 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND EPIDIDYMIS, RT 0.66 0.144 SKIN SPLEEN STOMACH SEMINAL VESICLES CAUDA EPID, RT 0.2960 0.065 TESTIS, RT THYMUS THYROID GLANDS TRACHEA FINAL BODY WT(G) 459. URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT LUNGS PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 787 of 1107**TABLE A39 (F0 MALES)

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ANIMAL NO. 91558 GROUP 5: 10000 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 1.94 0.458 PAS STAIN EXAMINED LIVER 13.27 3.135 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED KIDNEYS 2.95 0.697 PAS STAIN EXAMINED SPLEEN 0.66 0.156 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED LUNGS 1.71 0.404 PAS STAIN EXAMINED TESTIS, RT 1.62 0.383 NO SIGNIFICANT TESTIS, LT 1.58 0.373 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS EPIDIDYMIS, LT 0.55 0.130 EYES HEART INTESTINE KIDNEYS CAUDA EPID, LT 0.2771 0.065 LIVER LN, MESENTERIC LUNGS PANCREAS PITUITARY 0.0107 0.003 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND EPIDIDYMIS, RT 0.62 0.146 SKIN SPLEEN STOMACH SEMINAL VESICLES CAUDA EPID, RT 0.2652 0.063 TESTIS, RT THYMUS THYROID GLANDS TRACHEA FINAL BODY WT(G) 423. URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT LUNGS PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 788 of 1107**TABLE A39 (F0 MALES)

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ANIMAL NO. 91571 GROUP 5: 10000 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 1.97 0.517 PAS STAIN EXAMINED LIVER 13.50 3.543 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED KIDNEYS 3.14 0.824 PAS STAIN EXAMINED SPLEEN 0.64 0.168 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED LUNGS 1.61 0.423 PAS STAIN EXAMINED TESTIS, RT 1.50 0.394 NO SIGNIFICANT TESTIS, LT 1.50 0.394 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS EPIDIDYMIS, LT 0.55 0.144 EYES HEART INTESTINE KIDNEYS CAUDA EPID, LT 0.2693 0.071 LIVER LN, MESENTERIC LUNGS PANCREAS PITUITARY 0.0125 0.003 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND EPIDIDYMIS, RT 0.58 0.152 SKIN SPLEEN STOMACH SEMINAL VESICLES CAUDA EPID, RT 0.2648 0.070 TESTIS, RT THYMUS THYROID GLANDS TRACHEA FINAL BODY WT(G) 381. URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT LUNGS PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 789 of 1107**TABLE A39 (F0 MALES)

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ANIMAL NO. 91575 GROUP 5: 10000 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 2.18 0.492 PAS STAIN EXAMINED LIVER 14.35 3.241 KIDNEYS GROSS: DILATED PELVIS 2 KIDNEYS 3.44 0.777 RIGHT SPLEEN 0.74 0.167 ^==> KIDNEYS: DILATATION, PELVIS LUNGS 1.85 0.418 KIDNEYS MICRO: DILATATION, PELVIS 2 TESTIS, RT 1.60 0.361 ONE KIDNEY EXAMINED TESTIS, LT 1.55 0.350 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED EPIDIDYMIS, LT 0.56 0.126 PAS STAIN EXAMINED CAUDA EPID, LT 0.2104 0.048 URETERS MICRO: NOT PRESENT FOR EXAMINATION PITUITARY 0.0122 0.003 NOT IN PLANE. FATTY TISSUE AND ARTERIOLES ONLY. EPIDIDYMIS, RT 0.59 0.133 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED CAUDA EPID, RT 0.2488 0.056 PAS STAIN EXAMINED FINAL BODY WT(G) 443. NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS EYES HEART INTESTINE LIVER LN, MESENTERIC LUNGS PANCREAS PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT THYMUS THYROID GLANDS TRACHEA URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT LUNGS PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

NOT PRESENT FOR EXAMINATION MICRO:URETERS**Page 790 of 1107**TABLE A39 (F0 MALES)

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ANIMAL NO. 91575 GROUP 5: 10000 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 791 of 1107**TABLE A39 (F0 MALES)

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ANIMAL NO. 91600 GROUP 5: 10000 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 2.13 0.475 PAS STAIN EXAMINED LIVER 15.48 3.455 LUNGS MICRO: MINERALIZATION, VASCULAR 1 KIDNEYS 3.24 0.723 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED SPLEEN 0.78 0.174 PAS STAIN EXAMINED LUNGS 1.63 0.364 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED TESTIS, RT 1.85 0.413 PAS STAIN EXAMINED TESTIS, LT 1.72 0.384 NO SIGNIFICANT EPIDIDYMIS, LT 0.64 0.143 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS CAUDA EPID, LT 0.3179 0.071 EYES HEART INTESTINE KIDNEYS PITUITARY 0.0132 0.003 LIVER LN, MESENTERIC LUNGS PANCREAS EPIDIDYMIS, RT 0.73 0.163 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND CAUDA EPID, RT 0.3173 0.071 SKIN SPLEEN STOMACH SEMINAL VESICLES FINAL BODY WT(G) 448. TESTIS, RT THYMUS THYROID GLANDS TRACHEA URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 792 of 1107**TABLE A39 (F0 MALES)

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ANIMAL NO. 91603 GROUP 5: 10000 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 1.93 0.468 PAS STAIN EXAMINED LIVER 18.11 4.396 LUNGS MICRO: ATELECTASIS 2 KIDNEYS 3.60 0.874 CONGESTION 2 SPLEEN 0.70 0.170 POST-TERMINAL LUNGS 1.72 0.417 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED TESTIS, RT 1.74 0.422 PAS STAIN EXAMINED TESTIS, LT 1.73 0.420 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED EPIDIDYMIS, LT 0.66 0.160 PAS STAIN EXAMINED CAUDA EPID, LT 0.2831 0.069 NO SIGNIFICANT PITUITARY 0.0123 0.003 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS EPIDIDYMIS, RT 0.68 0.165 EYES HEART INTESTINE KIDNEYS CAUDA EPID, RT 0.2552 0.062 LIVER LN, MESENTERIC LUNGS PANCREAS FINAL BODY WT(G) 412. PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT THYMUS THYROID GLANDS TRACHEA URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 793 of 1107**TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 58 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91604 GROUP 5: 10000 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 1.89 0.438 PAS STAIN EXAMINED LIVER 15.12 3.502 KIDNEYS GROSS: AREA(S), DEPRESSED P KIDNEYS 3.14 0.727 FEW, 2 MM IN DIAMETER, IN CORTEX, LEFT SPLEEN 0.70 0.162 ^==> KIDNEYS: DEGENERATION, TUBULAR LUNGS 1.64 0.380 KIDNEYS MICRO: DEGENERATION, TUBULAR 1 TESTIS, RT 1.75 0.405 FOCAL, SINGLE TUBULE DROPOUT TESTIS, LT 1.71 0.396 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED EPIDIDYMIS, LT 0.64 0.148 PAS STAIN EXAMINED CAUDA EPID, LT 0.2876 0.067 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED PITUITARY 0.0149 0.003 PAS STAIN EXAMINED EPIDIDYMIS, RT 0.68 0.157 NO SIGNIFICANT CAUDA EPID, RT 0.2619 0.061 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS FINAL BODY WT(G) 432. EYES HEART INTESTINE LIVER LN, MESENTERIC LUNGS PANCREAS PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT THYMUS THYROID GLANDS TRACHEA URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT LUNGS PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 794 of 1107**TABLE A39 (F0 MALES)

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ANIMAL NO. 91605 GROUP 5: 10000 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 2.00 0.500 PAS STAIN EXAMINED LIVER 13.23 3.307 LUNGS MICRO: MINERALIZATION, VASCULAR 1 KIDNEYS 2.96 0.740 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED SPLEEN 0.65 0.162 PAS STAIN EXAMINED LUNGS 1.41 0.352 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED TESTIS, RT 1.83 0.458 PAS STAIN EXAMINED TESTIS, LT 1.86 0.465 NO SIGNIFICANT EPIDIDYMIS, LT 0.60 0.150 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS CAUDA EPID, LT 0.3019 0.075 EYES HEART INTESTINE KIDNEYS PITUITARY 0.0127 0.003 LIVER LN, MESENTERIC LUNGS PANCREAS EPIDIDYMIS, RT 0.61 0.153 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND CAUDA EPID, RT 0.2506 0.063 SKIN SPLEEN STOMACH SEMINAL VESICLES FINAL BODY WT(G) 400. TESTIS, RT THYMUS THYROID GLANDS TRACHEA URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 795 of 1107**TABLE A39 (F0 MALES)

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ANIMAL NO. 91612 GROUP 5: 10000 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 2.16 0.557 PAS STAIN EXAMINED LIVER 14.21 3.662 LUNGS MICRO: MINERALIZATION, VASCULAR 1 KIDNEYS 3.12 0.804 PROSTATE MICRO: INFLAMMATION, SUBACUTE 2 SPLEEN 0.69 0.178 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED LUNGS 1.39 0.358 PAS STAIN EXAMINED TESTIS, RT 1.90 0.490 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED TESTIS, LT 1.86 0.479 PAS STAIN EXAMINED EPIDIDYMIS, LT 0.66 0.170 NO SIGNIFICANT CAUDA EPID, LT 0.3086 0.080 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS PITUITARY 0.0134 0.003 EYES HEART INTESTINE KIDNEYS EPIDIDYMIS, RT 0.74 0.191 LIVER LN, MESENTERIC LUNGS PANCREAS CAUDA EPID, RT 0.2796 0.072 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND FINAL BODY WT(G) 388. SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT THYMUS THYROID GLANDS TRACHEA URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT PITUITARY SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 796 of 1107**TABLE A39 (F0 MALES)

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ANIMAL NO. 91618 GROUP 5: 10000 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 2.17 0.531 PAS STAIN EXAMINED LIVER 14.65 3.582 LUNGS MICRO: MINERALIZATION, VASCULAR 1 KIDNEYS 3.35 0.819 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED SPLEEN 0.83 0.203 PAS STAIN EXAMINED LUNGS 1.62 0.396 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED TESTIS, RT 1.59 0.389 PAS STAIN EXAMINED TESTIS, LT 1.55 0.379 NO SIGNIFICANT EPIDIDYMIS, LT 0.58 0.142 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS CAUDA EPID, LT 0.2653 0.065 EYES HEART INTESTINE KIDNEYS PITUITARY 0.0157 0.004 LIVER LN, MESENTERIC LUNGS PANCREAS EPIDIDYMIS, RT 0.63 0.154 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND CAUDA EPID, RT 0.2693 0.066 SKIN SPLEEN STOMACH SEMINAL VESICLES FINAL BODY WT(G) 409. TESTIS, RT THYMUS THYROID GLANDS TRACHEA URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT**Page 797 of 1107**TABLE A39 (F0 MALES)

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ANIMAL NO. 91619 GROUP 5: 10000 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED BRAIN 2.05 0.500 PAS STAIN EXAMINED LIVER 13.77 3.359 LUNGS MICRO: ATELECTASIS 3 KIDNEYS 3.24 0.790 POST-TERMINAL SPLEEN 0.74 0.180 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED LUNGS 1.68 0.410 PAS STAIN EXAMINED TESTIS, RT 1.61 0.393 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED TESTIS, LT 1.62 0.395 PAS STAIN EXAMINED EPIDIDYMIS, LT 0.53 0.129 NO SIGNIFICANT CAUDA EPID, LT 0.2584 0.063 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS PITUITARY 0.0131 0.003 EYES HEART INTESTINE KIDNEYS EPIDIDYMIS, RT 0.56 0.137 LIVER LN, MESENTERIC LUNGS PANCREAS CAUDA EPID, RT 0.2330 0.057 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND FINAL BODY WT(G) 410. SKIN SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT THYMUS THYROID GLANDS TRACHEA URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT VAS DEFERENS MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT PGRHv4.68 02/18/2014**Page 798 of 1107**TABLE A40 (F0 FEMALES - FAILED TO DELIVER)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91623 GROUP 4: 175 PPM FEMALE SCHEDULED EUTH 12/05/13 DATE OF DEATH: 12/05/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: NONGRAVID- AMMONIUM SULFIDE NEGATIVE P BRAIN 1.88 0.608 ^==> GROSS UNCONFIRMED LIVER 11.03 3.565 UTERUS GROSS: CONTENTS, CLEAR FLUID P KIDNEYS 2.06 0.666 BOTH HORNS SPLEEN 0.59 0.191 ^==> GROSS UNCONFIRMED LUNGS 1.75 0.566 NO SIGNIFICANT OVARIES 0.1358 0.044 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES PITUITARY 0.0154 0.005 HEART INTESTINE KIDNEYS LIVER FINAL BODY WT(G) 309. LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER CERVIX VAGINA DIAPHRAGM MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY SPLEEN CERVIX VAGINA

NOT PRESENT FOR EXAMINATION MICRO:UTERUS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING PGRHv4.68 02/18/2014**Page 799 of 1107**TABLE A41 (F0 FEMALES - TOTAL LITTER LOSS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91654 GROUP 4: 175 PPM FEMALE SCHEDULED EUTH 11/27/13 DATE OF DEATH: 11/27/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 2.00 8,11 LIVER 16.62 ^==> GROSS UNCONFIRMED KIDNEYS 2.25 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.92 8,11 LUNGS 1.50 ^==> GROSS UNCONFIRMED OVARIES 0.1465 PITUITARY MICRO: CYST, PARS DISTALIS P PITUITARY 0.0167 UTERUS MICRO: IMPLANTATION SITE P
BILATERAL EXUDATE, INFLAMMATORY 2 WITHIN LUMEN OF UTERUS; NEUTROPHILS NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:LUNGS MAMMARY GLAND OVARIES SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING PGRHv4.68 02/18/2014**Page 800 of 1107**

## FINAL **REPORT**

Contents : Volume 4 of 4 Appendix G (continued)

Study Title : An Inhalation Reproduction/Developmental Toxicity

Screening Study

of 2

- Bromo

- 3,3,3

- Trifluoropropene in Rats

Laboratory

Project ID : WI L

- 65501

Author: Tammy e L. Edwards, BS

Test Guideline : OECD Guideline 421

Study Completion Date : 21 March 2014

Performing Laboratory : WI L Research 1407 George Road Ashland, OH 44805

- 8946

Sponsor : American Pacific Corporation 3883 Howard Hughes Parkway , Suite 700 L as Vegas, NV 89169

Total Number of Pages: 1 107

**Page 801 of 1107**

## WI L

- 65501 2

- Bromo

- 3,3,3

- Trifluoropropene

American Pacific Corporation



# APPENDIX **G**

Individual Animal Data (continued)

**Page 802 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91629 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 11/25/13 DATE OF DEATH: 11/25/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.96 0.636 8,8 LIVER 12.71 4.127 ^==> GROSS UNCONFIRMED KIDNEYS 2.16 0.701 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.67 0.218 8,8 LUNGS 1.47 0.477 ^==> GROSS UNCONFIRMED OVARIES 0.1023 0.033 LUNGS MICRO: MINERALIZATION, VASCULAR 1 PITUITARY 0.0143 0.005 UTERUS MICRO: IMPLANTATION SITE P FINAL BODY WT(G) 308. BILATERAL NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:MAMMARY GLAND OVARIES PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 803 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91630 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 11/26/13 DATE OF DEATH: 11/26/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.96 0.605 10,6 LIVER 15.97 4.929 ^==> GROSS UNCONFIRMED KIDNEYS 2.32 0.716 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.59 0.182 10,6 LUNGS 1.53 0.472 ^==> GROSS UNCONFIRMED OVARIES 0.0903 0.028 LUNGS MICRO: ATELECTASIS 3 PITUITARY 0.0198 0.006 POST-TERMINAL FINAL BODY WT(G) 324. UTERUS MICRO: IMPLANTATION SITE P
BILATERAL NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:MAMMARY GLAND OVARIES PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 804 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91633 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 11/23/13 DATE OF DEATH: 11/23/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 2.02 0.560 11,5 LIVER 14.39 3.986 ^==> GROSS UNCONFIRMED KIDNEYS 2.41 0.668 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.82 0.227 11,6 LUNGS 1.33 0.368 ^==> GROSS UNCONFIRMED OVARIES 0.1462 0.040 UTERUS MICRO: IMPLANTATION SITE P PITUITARY 0.0214 0.006 UNILATERAL FINAL BODY WT(G) 361. NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 805 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91637 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 11/22/13 DATE OF DEATH: 11/22/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.94 0.606 8,7 LIVER 12.77 3.991 ^==> GROSS UNCONFIRMED KIDNEYS 2.31 0.722 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.64 0.200 8,7 LUNGS 1.25 0.391 ^==> GROSS UNCONFIRMED OVARIES 0.1021 0.032 LUNGS MICRO: MINERALIZATION, VASCULAR 1 PITUITARY 0.0173 0.005 UTERUS MICRO: IMPLANTATION SITE P FINAL BODY WT(G) 320. UNILATERAL NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:MAMMARY GLAND OVARIES PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 806 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91639 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 11/25/13 DATE OF DEATH: 11/25/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.95 0.540 6,11 LIVER 14.15 3.920 ^==> GROSS UNCONFIRMED KIDNEYS 2.13 0.590 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.65 0.180 8,12 LUNGS 1.54 0.427 ^==> GROSS UNCONFIRMED OVARIES 0.1524 0.042 LUNGS MICRO: MINERALIZATION, VASCULAR 1 PITUITARY 0.0201 0.006 UTERUS MICRO: IMPLANTATION SITE P FINAL BODY WT(G) 361. UNILATERAL NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:MAMMARY GLAND OVARIES PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 807 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91644 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 11/23/13 DATE OF DEATH: 11/23/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.89 0.604 7,11 LIVER 13.08 4.179 ^==> GROSS UNCONFIRMED KIDNEYS 2.37 0.757 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.66 0.211 7,11 LUNGS 1.57 0.502 ^==> GROSS UNCONFIRMED OVARIES 0.1213 0.039 OVARIES MICRO: CYST, FOLLICULAR P PITUITARY 0.0225 0.007 SOLITARY, ON SLIDE 11A FINAL BODY WT(G) 313. UTERUS MICRO: IMPLANTATION SITE P UNILATERAL NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:LUNGS MAMMARY GLAND PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 808 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91645 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 11/26/13 DATE OF DEATH: 11/26/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.98 0.579 7,9 LIVER 15.82 4.626 ^==> GROSS UNCONFIRMED KIDNEYS 2.32 0.678 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.61 0.178 7,9 LUNGS 1.50 0.439 ^==> GROSS UNCONFIRMED OVARIES 0.1106 0.032 UTERUS MICRO: IMPLANTATION SITE P PITUITARY 0.0201 0.006 BILATERAL FINAL BODY WT(G) 342. NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 809 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91648 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 11/23/13 DATE OF DEATH: 11/23/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.95 0.543 6,8 LIVER 14.92 4.156 ^==> GROSS UNCONFIRMED KIDNEYS 2.34 0.652 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.77 0.214 6,9 LUNGS 1.47 0.409 ^==> GROSS UNCONFIRMED OVARIES 0.1255 0.035 UTERUS MICRO: IMPLANTATION SITE P PITUITARY 0.0203 0.006 BILATERAL FINAL BODY WT(G) 359. NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 810 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91653 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 11/25/13 DATE OF DEATH: 11/25/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.95 0.562 7,10 LIVER 13.47 3.882 ^==> GROSS UNCONFIRMED KIDNEYS 2.20 0.634 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.75 0.216 7,10 LUNGS 1.19 0.343 ^==> GROSS UNCONFIRMED OVARIES 0.1329 0.038 LUNGS MICRO: ATELECTASIS 2 PITUITARY 0.0220 0.006 UTERUS MICRO: IMPLANTATION SITE P FINAL BODY WT(G) 347. UNILATERAL NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:MAMMARY GLAND OVARIES PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 811 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91660 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 11/25/13 DATE OF DEATH: 11/25/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 2.09 0.568 7,8 LIVER 15.74 4.277 ^==> GROSS UNCONFIRMED KIDNEYS 2.42 0.658 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.72 0.196 8,10 LUNGS 1.53 0.416 ^==> GROSS UNCONFIRMED OVARIES 0.1325 0.036 UTERUS MICRO: IMPLANTATION SITE P PITUITARY 0.0271 0.007 BILATERAL FINAL BODY WT(G) 368. NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 812 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91670 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 11/26/13 DATE OF DEATH: 11/26/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 2.01 0.605 6,8 LIVER 13.90 4.187 ^==> GROSS UNCONFIRMED KIDNEYS 2.31 0.696 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.59 0.178 6,8 LUNGS 1.43 0.431 ^==> GROSS UNCONFIRMED OVARIES 0.1371 0.041 UTERUS MICRO: IMPLANTATION SITE P PITUITARY 0.0205 0.006 BILATERAL FINAL BODY WT(G) 332. NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 813 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91672 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 11/26/13 DATE OF DEATH: 11/26/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 2.06 0.551 6,10 LIVER 17.93 4.794 ^==> GROSS UNCONFIRMED KIDNEYS 2.37 0.634 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.91 0.243 6,10 LUNGS 1.76 0.471 ^==> GROSS UNCONFIRMED OVARIES 0.1561 0.042 UTERUS MICRO: IMPLANTATION SITE P PITUITARY 0.0229 0.006 BILATERAL FINAL BODY WT(G) 374. CERVIX MICRO: NO SIGNIFICANT CHANGES OBSERVED MULTIPLE IMPLANTATION SITES OBSERVED IN CERVIX SECTION NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 814 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91632 GROUP 2: 50 PPM FEMALE SCHEDULED EUTH 11/27/13 DATE OF DEATH: 11/27/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.87 0.583 6,9 LIVER 12.83 3.997 ^==> GROSS UNCONFIRMED KIDNEYS 2.39 0.745 GENERAL COMMENT GROSS: ORGAN DAMAGED AT NECROPSY P SPLEEN 0.59 0.184 BRAIN LUNGS 1.45 0.452 ^==> GROSS UNCONFIRMED OVARIES 0.1072 0.033 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P PITUITARY 0.0188 0.006 6,10 FINAL BODY WT(G) 321. ^==> GROSS UNCONFIRMED NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 815 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91640 GROUP 2: 50 PPM FEMALE SCHEDULED EUTH 11/27/13 DATE OF DEATH: 11/27/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 2.02 0.558 5,9 LIVER 15.05 4.157 ^==> GROSS UNCONFIRMED KIDNEYS 2.55 0.704 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 1.09 0.301 8,9 LUNGS 1.89 0.522 ^==> GROSS UNCONFIRMED OVARIES 0.1252 0.035 GENERAL COMMENT GROSS: ORGAN DAMAGED AT NECROPSY P PITUITARY 0.0206 0.006 BRAIN FINAL BODY WT(G) 362. ^==> GROSS UNCONFIRMED NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 816 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91642 GROUP 2: 50 PPM FEMALE SCHEDULED EUTH 11/24/13 DATE OF DEATH: 11/24/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.88 0.539 5,10 LIVER 14.48 4.149 ^==> GROSS UNCONFIRMED KIDNEYS 2.53 0.725 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.80 0.229 5,11 LUNGS 1.51 0.433 ^==> GROSS UNCONFIRMED OVARIES 0.0948 0.027 NO SIGNIFICANT PITUITARY 0.0212 0.006 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES FINAL BODY WT(G) 349. HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 817 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91647 GROUP 2: 50 PPM FEMALE SCHEDULED EUTH 11/26/13 DATE OF DEATH: 11/26/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.80 0.608 6,7 LIVER 12.87 4.348 ^==> GROSS UNCONFIRMED KIDNEYS 2.04 0.689 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.58 0.196 6,7 LUNGS 1.39 0.470 ^==> GROSS UNCONFIRMED OVARIES 0.0989 0.033 KIDNEYS GROSS: PALE P PITUITARY 0.0189 0.006 BILATERAL FINAL BODY WT(G) 296. ^==> GROSS UNCONFIRMED NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:KIDNEYS

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 818 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91651 GROUP 2: 50 PPM FEMALE SCHEDULED EUTH 11/25/13 DATE OF DEATH: 11/25/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.91 0.581 6,8 LIVER 14.86 4.517 ^==> GROSS UNCONFIRMED KIDNEYS 2.37 0.720 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.61 0.185 6,8 LUNGS 1.69 0.514 ^==> GROSS UNCONFIRMED OVARIES 0.0894 0.027 NO SIGNIFICANT PITUITARY 0.0168 0.005 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES FINAL BODY WT(G) 329. HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 819 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91659 GROUP 2: 50 PPM FEMALE SCHEDULED EUTH 11/24/13 DATE OF DEATH: 11/24/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 2.10 0.566 7,7 LIVER 16.38 4.415 ^==> GROSS UNCONFIRMED KIDNEYS 2.43 0.655 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.82 0.221 7,7 LUNGS 1.51 0.407 ^==> GROSS UNCONFIRMED OVARIES 0.1208 0.033 NO SIGNIFICANT PITUITARY 0.0205 0.006 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES FINAL BODY WT(G) 371. HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 820 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91661 GROUP 2: 50 PPM FEMALE SCHEDULED EUTH 11/23/13 DATE OF DEATH: 11/23/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.92 0.610 10,7 LIVER 13.20 4.190 ^==> GROSS UNCONFIRMED KIDNEYS 2.35 0.746 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.61 0.194 10,7 LUNGS 1.54 0.489 ^==> GROSS UNCONFIRMED OVARIES 0.1072 0.034 NO SIGNIFICANT PITUITARY 0.0160 0.005 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES FINAL BODY WT(G) 315. HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 821 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91663 GROUP 2: 50 PPM FEMALE SCHEDULED EUTH 11/25/13 DATE OF DEATH: 11/25/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.94 0.599 4,11 LIVER 12.37 3.818 ^==> GROSS UNCONFIRMED KIDNEYS 2.13 0.657 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.64 0.198 4,11 LUNGS 1.40 0.432 ^==> GROSS UNCONFIRMED OVARIES 0.1085 0.033 NO SIGNIFICANT PITUITARY 0.0183 0.006 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES FINAL BODY WT(G) 324. HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 822 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91669 GROUP 2: 50 PPM FEMALE SCHEDULED EUTH 11/23/13 DATE OF DEATH: 11/23/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 2.09 0.643 8,8 LIVER 13.48 4.148 ^==> GROSS UNCONFIRMED KIDNEYS 2.11 0.649 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.84 0.258 8,8 LUNGS 1.49 0.458 ^==> GROSS UNCONFIRMED OVARIES 0.1419 0.044 NO SIGNIFICANT PITUITARY 0.0171 0.005 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES FINAL BODY WT(G) 325. HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 823 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91673 GROUP 2: 50 PPM FEMALE SCHEDULED EUTH 11/26/13 DATE OF DEATH: 11/26/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 2.00 0.623 4,12 LIVER 14.97 4.664 ^==> GROSS UNCONFIRMED KIDNEYS 2.51 0.782 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.70 0.218 4,12 LUNGS 1.65 0.514 ^==> GROSS UNCONFIRMED OVARIES 0.1319 0.041 NO SIGNIFICANT PITUITARY 0.0200 0.006 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES FINAL BODY WT(G) 321. HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 824 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91683 GROUP 2: 50 PPM FEMALE SCHEDULED EUTH 11/27/13 DATE OF DEATH: 11/27/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.89 0.589 8,5 LIVER 13.75 4.283 ^==> GROSS UNCONFIRMED KIDNEYS 2.19 0.682 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.74 0.231 8,6 LUNGS 1.43 0.445 ^==> GROSS UNCONFIRMED OVARIES 0.1099 0.034 NO SIGNIFICANT PITUITARY 0.0194 0.006 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES FINAL BODY WT(G) 321. HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 825 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91685 GROUP 2: 50 PPM FEMALE SCHEDULED EUTH 11/23/13 DATE OF DEATH: 11/23/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 2.04 0.699 6,4 LIVER 11.44 3.918 ^==> GROSS UNCONFIRMED KIDNEYS 2.02 0.692 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.57 0.195 6,10 LUNGS 1.45 0.497 ^==> GROSS UNCONFIRMED OVARIES 0.1351 0.046 NO SIGNIFICANT PITUITARY 0.0198 0.007 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES FINAL BODY WT(G) 292. HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 826 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91620 GROUP 3: 100 PPM FEMALE SCHEDULED EUTH 11/26/13 DATE OF DEATH: 11/26/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.89 0.538 7,8 LIVER 13.72 3.909 ^==> GROSS UNCONFIRMED KIDNEYS 2.31 0.658 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.98 0.279 7,8 LUNGS 1.44 0.410 ^==> GROSS UNCONFIRMED OVARIES 0.1291 0.037 NO SIGNIFICANT PITUITARY 0.0166 0.005 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES FINAL BODY WT(G) 351. HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 827 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91628 GROUP 3: 100 PPM FEMALE SCHEDULED EUTH 11/24/13 DATE OF DEATH: 11/24/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.93 0.668 10,5 LIVER 12.30 4.256 ^==> GROSS UNCONFIRMED KIDNEYS 2.02 0.699 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.59 0.204 10,5 LUNGS 1.39 0.481 ^==> GROSS UNCONFIRMED OVARIES 0.1142 0.040 NO SIGNIFICANT PITUITARY 0.0161 0.006 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES FINAL BODY WT(G) 289. HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 828 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91631 GROUP 3: 100 PPM FEMALE SCHEDULED EUTH 11/24/13 DATE OF DEATH: 11/24/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.87 0.533 4,11 LIVER 15.89 4.527 ^==> GROSS UNCONFIRMED KIDNEYS 2.79 0.795 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.76 0.217 7,12 LUNGS 1.43 0.407 ^==> GROSS UNCONFIRMED OVARIES 0.1094 0.031 NO SIGNIFICANT PITUITARY 0.0159 0.005 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES FINAL BODY WT(G) 351. HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 829 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91636 GROUP 3: 100 PPM FEMALE SCHEDULED EUTH 11/25/13 DATE OF DEATH: 11/25/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.86 0.644 9,7 LIVER 12.10 4.187 ^==> GROSS UNCONFIRMED KIDNEYS 2.07 0.716 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.72 0.249 9,7 LUNGS 1.41 0.488 ^==> GROSS UNCONFIRMED OVARIES 0.1071 0.037 NO SIGNIFICANT PITUITARY 0.0176 0.006 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES FINAL BODY WT(G) 289. HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 830 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91649 GROUP 3: 100 PPM FEMALE SCHEDULED EUTH 11/23/13 DATE OF DEATH: 11/23/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.87 0.613 8,8 LIVER 13.32 4.367 ^==> GROSS UNCONFIRMED KIDNEYS 2.22 0.728 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.89 0.292 8,8 LUNGS 1.47 0.482 ^==> GROSS UNCONFIRMED OVARIES 0.1284 0.042 NO SIGNIFICANT PITUITARY 0.0121 0.004 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES FINAL BODY WT(G) 305. HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 831 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91650 GROUP 3: 100 PPM FEMALE SCHEDULED EUTH 11/23/13 DATE OF DEATH: 11/23/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.88 0.530 9,5 LIVER 14.91 4.200 ^==> GROSS UNCONFIRMED KIDNEYS 2.46 0.693 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.94 0.265 9,6 LUNGS 1.62 0.456 ^==> GROSS UNCONFIRMED OVARIES 0.1214 0.034 NO SIGNIFICANT PITUITARY 0.0210 0.006 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES FINAL BODY WT(G) 355. HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 832 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91656 GROUP 3: 100 PPM FEMALE SCHEDULED EUTH 11/28/13 DATE OF DEATH: 11/28/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.93 0.585 8,8 LIVER 13.29 4.027 ^==> GROSS UNCONFIRMED KIDNEYS 2.22 0.673 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.60 0.182 8,9 LUNGS 1.51 0.458 ^==> GROSS UNCONFIRMED OVARIES 0.0969 0.029 NO SIGNIFICANT PITUITARY 0.0159 0.005 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES FINAL BODY WT(G) 330. HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 833 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91671 GROUP 3: 100 PPM FEMALE SCHEDULED EUTH 11/28/13 DATE OF DEATH: 11/28/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.90 0.549 6,9 LIVER 14.61 4.223 ^==> GROSS UNCONFIRMED KIDNEYS 2.22 0.642 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 1.19 0.344 6,9 LUNGS 1.41 0.408 ^==> GROSS UNCONFIRMED OVARIES 0.1100 0.032 NO SIGNIFICANT PITUITARY 0.0179 0.005 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES FINAL BODY WT(G) 346. HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 834 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91675 GROUP 3: 100 PPM FEMALE SCHEDULED EUTH 11/24/13 DATE OF DEATH: 11/24/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 2.06 0.574 5,9 LIVER 14.93 4.159 ^==> GROSS UNCONFIRMED KIDNEYS 2.45 0.682 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.91 0.253 5, 9 LUNGS 1.56 0.435 ^==> GROSS UNCONFIRMED OVARIES 0.1321 0.037 GENERAL COMMENT GROSS: ORGAN DAMAGED AT NECROPSY P PITUITARY 0.0140 0.004 BRAIN FINAL BODY WT(G) 359. ^==> GROSS UNCONFIRMED NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 835 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91677 GROUP 3: 100 PPM FEMALE SCHEDULED EUTH 11/25/13 DATE OF DEATH: 11/25/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 2.00 0.647 5,1 LIVER 11.13 3.602 ^==> GROSS UNCONFIRMED KIDNEYS 2.20 0.712 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.66 0.214 5,11 LUNGS 1.37 0.443 ^==> GROSS UNCONFIRMED OVARIES 0.1184 0.038 SPLEEN GROSS: ADHESIONS P PITUITARY 0.0138 0.004 ATTACHED TO ADIPOSE TISSUE ADJACENT TO PANCREAS FINAL BODY WT(G) 309. ^==> SPLEEN: FIBROSIS, CAPSULAR SPLEEN MICRO: FIBROSIS, CAPSULAR 2 COMPATIBLE WITH ADHESION NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 836 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91679 GROUP 3: 100 PPM FEMALE SCHEDULED EUTH 11/23/13 DATE OF DEATH: 11/23/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.94 0.574 6,9 LIVER 13.87 4.104 ^==> GROSS UNCONFIRMED KIDNEYS 2.25 0.666 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 1.15 0.340 6,9 LUNGS 1.90 0.562 ^==> GROSS UNCONFIRMED OVARIES 0.1544 0.046 NO SIGNIFICANT PITUITARY 0.0126 0.004 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES FINAL BODY WT(G) 338. HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 837 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91684 GROUP 3: 100 PPM FEMALE SCHEDULED EUTH 11/24/13 DATE OF DEATH: 11/24/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.96 0.685 7,9 LIVER 12.90 4.510 ^==> GROSS UNCONFIRMED KIDNEYS 1.76 0.615 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.53 0.185 7,9 LUNGS 1.48 0.517 ^==> GROSS UNCONFIRMED OVARIES 0.1091 0.038 NO SIGNIFICANT PITUITARY 0.0132 0.005 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES FINAL BODY WT(G) 286. HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 838 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91622 GROUP 4: 175 PPM FEMALE SCHEDULED EUTH 11/23/13 DATE OF DEATH: 11/23/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.96 0.651 4,11 LIVER 14.01 4.654 ^==> GROSS UNCONFIRMED KIDNEYS 2.10 0.698 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.96 0.319 4,11 LUNGS 1.68 0.558 ^==> GROSS UNCONFIRMED OVARIES 0.1147 0.038 OVARIES MICRO: NO SIGNIFICANT CHANGES OBSERVED PITUITARY 0.0162 0.005 MINIMAL TISSUE OTHER THAN CORPORA LUTEA FINAL BODY WT(G) 301. UTERUS MICRO: IMPLANTATION SITE P NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 839 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91626 GROUP 4: 175 PPM FEMALE SCHEDULED EUTH 11/26/13 DATE OF DEATH: 11/26/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 2.14 0.583 8,7 LIVER 15.70 4.278 ^==> GROSS UNCONFIRMED KIDNEYS 2.26 0.616 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.77 0.210 8,7 LUNGS 1.54 0.420 ^==> GROSS UNCONFIRMED OVARIES 0.1211 0.033 UTERUS MICRO: IMPLANTATION SITE P PITUITARY 0.0247 0.007 BILATERAL FINAL BODY WT(G) 367. NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 840 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91643 GROUP 4: 175 PPM FEMALE SCHEDULED EUTH 11/29/13 DATE OF DEATH: 11/29/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 2.07 0.575 6,9 LIVER 15.14 4.206 ^==> GROSS UNCONFIRMED KIDNEYS 2.32 0.644 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 1.13 0.314 7,11 LUNGS 1.60 0.444 ^==> GROSS UNCONFIRMED OVARIES 0.1118 0.031 OVARIES MICRO: NO SIGNIFICANT CHANGES OBSERVED PITUITARY 0.0199 0.006 NO FOLLICLES IN THE SMALL AMOUNT OF STROMA PRESENT FINAL BODY WT(G) 360. PITUITARY MICRO: NO SIGNIFICANT CHANGES OBSERVED PARS DISTALIS ONLY UTERUS MICRO: IMPLANTATION SITE P BILATERAL NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 841 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91657 GROUP 4: 175 PPM FEMALE SCHEDULED EUTH 12/04/13 DATE OF DEATH: 12/04/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.89 0.534 9,7 LIVER 14.64 4.136 ^==> GROSS UNCONFIRMED KIDNEYS 2.70 0.763 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.77 0.218 9,8 LUNGS 1.64 0.463 ^==> GROSS UNCONFIRMED OVARIES 0.1375 0.039 UTERUS MICRO: IMPLANTATION SITE P PITUITARY 0.0174 0.005 BILATERAL FINAL BODY WT(G) 354. NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 842 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91662 GROUP 4: 175 PPM FEMALE SCHEDULED EUTH 11/26/13 DATE OF DEATH: 11/26/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.92 0.582 8,7 LIVER 14.66 4.442 ^==> GROSS UNCONFIRMED KIDNEYS 2.39 0.724 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.76 0.230 9,9 LUNGS 1.53 0.464 ^==> GROSS UNCONFIRMED OVARIES 0.1244 0.038 OVARIES MICRO: HEMORRHAGE 2 PITUITARY 0.0147 0.004 FOCAL, WITHIN CORPORA LUTEUM FINAL BODY WT(G) 330. UTERUS MICRO: IMPLANTATION SITE P
BILATERAL NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:LUNGS MAMMARY GLAND PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 843 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91666 GROUP 4: 175 PPM FEMALE SCHEDULED EUTH 11/24/13 DATE OF DEATH: 11/24/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.88 0.660 6,6 LIVER 11.95 4.193 ^==> GROSS UNCONFIRMED KIDNEYS 2.03 0.712 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.79 0.277 7,6 LUNGS 1.42 0.498 ^==> GROSS UNCONFIRMED OVARIES 0.0850 0.030 UTERUS MICRO: IMPLANTATION SITE P PITUITARY 0.0105 0.004 BILATERAL FINAL BODY WT(G) 285. NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 844 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91676 GROUP 4: 175 PPM FEMALE SCHEDULED EUTH 11/25/13 DATE OF DEATH: 11/25/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.97 0.621 5,9 LIVER 13.90 4.385 ^==> GROSS UNCONFIRMED KIDNEYS 2.42 0.763 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.80 0.252 5,9 LUNGS 1.46 0.461 ^==> GROSS UNCONFIRMED OVARIES 0.0890 0.028 UTERUS MICRO: IMPLANTATION SITE P PITUITARY 0.0174 0.005 BILATERAL FINAL BODY WT(G) 317. NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 845 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91678 GROUP 4: 175 PPM FEMALE SCHEDULED EUTH 11/24/13 DATE OF DEATH: 11/24/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 2.08 0.525 9,8 LIVER 16.10 4.066 ^==> GROSS UNCONFIRMED KIDNEYS 2.38 0.601 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.90 0.227 9,8 LUNGS 1.61 0.407 ^==> GROSS UNCONFIRMED OVARIES 0.1343 0.034 OVARIES MICRO: NO SIGNIFICANT CHANGES OBSERVED PITUITARY 0.0221 0.006 ONE OVARY HAS ONLY CORPORA LUTEA IN SECTION FINAL BODY WT(G) 396. UTERUS MICRO: IMPLANTATION SITE P
BILATERAL NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 846 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91681 GROUP 4: 175 PPM FEMALE SCHEDULED EUTH 12/03/13 DATE OF DEATH: 12/03/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 2.00 0.625 6,9 LIVER 13.84 4.325 ^==> GROSS UNCONFIRMED KIDNEYS 2.26 0.706 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.69 0.216 6,9 LUNGS 1.49 0.466 ^==> GROSS UNCONFIRMED OVARIES 0.1230 0.038 SPLEEN GROSS: ADHESIONS P PITUITARY 0.0170 0.005 ATTACHED TO PANCREAS FINAL BODY WT(G) 320. ^==> SPLEEN: FIBROSIS, CAPSULAR SPLEEN MICRO: FIBROSIS, CAPSULAR 2 COMPATIBLE WITH ADHESION NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY UTERUS CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 847 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91682 GROUP 4: 175 PPM FEMALE SCHEDULED EUTH 11/26/13 DATE OF DEATH: 11/26/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.97 0.583 8,7 LIVER 14.44 4.272 ^==> GROSS UNCONFIRMED KIDNEYS 2.42 0.716 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 1.10 0.325 9,8 LUNGS 1.46 0.432 ^==> GROSS UNCONFIRMED OVARIES 0.1347 0.040 UTERUS MICRO: IMPLANTATION SITE P PITUITARY 0.0146 0.004 BILATERAL FINAL BODY WT(G) 338. NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 848 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91624 GROUP 5: 10000 PPM FEMALE SCHEDULED EUTH 11/25/13 DATE OF DEATH: 11/25/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 2.03 0.632 5,12 LIVER 12.89 4.016 ^==> GROSS UNCONFIRMED KIDNEYS 2.18 0.679 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.75 0.234 6,12 LUNGS 1.47 0.458 ^==> GROSS UNCONFIRMED OVARIES 0.1124 0.035 MAMMARY GLAND MICRO: INFLAMMATION, SUPPURATIVE 2 PITUITARY 0.0161 0.005 UTERUS MICRO: IMPLANTATION SITE P FINAL BODY WT(G) 321. BILATERAL NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:LUNGS OVARIES PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 849 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91625 GROUP 5: 10000 PPM FEMALE SCHEDULED EUTH 11/26/13 DATE OF DEATH: 11/26/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.85 0.631 7,7 LIVER 12.81 4.372 ^==> GROSS UNCONFIRMED KIDNEYS 1.74 0.594 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.56 0.191 8,8 LUNGS 1.20 0.410 ^==> GROSS UNCONFIRMED OVARIES 0.1289 0.044 UTERUS MICRO: IMPLANTATION SITE P PITUITARY 0.0199 0.007 BILATERAL FINAL BODY WT(G) 293. NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 850 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91627 GROUP 5: 10000 PPM FEMALE SCHEDULED EUTH 11/23/13 DATE OF DEATH: 11/23/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.92 0.634 3,9 LIVER 12.77 4.215 ^==> GROSS UNCONFIRMED KIDNEYS 2.27 0.749 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.68 0.224 3,9 LUNGS 1.42 0.469 ^==> GROSS UNCONFIRMED OVARIES 0.1083 0.036 LUNGS MICRO: ATELECTASIS 3 PITUITARY 0.0189 0.006 UTERUS MICRO: IMPLANTATION SITE P FINAL BODY WT(G) 303. BILATERAL NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:MAMMARY GLAND OVARIES PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 851 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

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ANIMAL NO. 91634 GROUP 5: 10000 PPM FEMALE SCHEDULED EUTH 11/26/13 DATE OF DEATH: 11/26/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.95 0.589 6,9 LIVER 13.39 4.045 ^==> GROSS UNCONFIRMED KIDNEYS 2.60 0.785 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.64 0.193 6,11 LUNGS 1.42 0.429 ^==> GROSS UNCONFIRMED OVARIES 0.1248 0.038 LUNGS MICRO: ATELECTASIS 2 PITUITARY 0.0169 0.005 POST-TERMINAL FINAL BODY WT(G) 331. UTERUS MICRO: IMPLANTATION SITE P
BILATERAL NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:MAMMARY GLAND OVARIES PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 852 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 51 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91635 GROUP 5: 10000 PPM FEMALE SCHEDULED EUTH 11/23/13 DATE OF DEATH: 11/23/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 2.13 0.630 8,6 LIVER 14.56 4.308 ^==> GROSS UNCONFIRMED KIDNEYS 2.11 0.624 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.73 0.216 8,7 LUNGS 1.53 0.453 ^==> GROSS UNCONFIRMED OVARIES 0.1147 0.034 OVARIES MICRO: NO SIGNIFICANT CHANGES OBSERVED PITUITARY 0.0193 0.006 MINIMAL TISSUE OTHER THAN CORPORA LUTEA FINAL BODY WT(G) 338. UTERUS MICRO: IMPLANTATION SITE P
BILATERAL NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 853 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 52 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91638 GROUP 5: 10000 PPM FEMALE SCHEDULED EUTH 11/25/13 DATE OF DEATH: 11/25/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 2.06 0.646 4,12 LIVER 11.86 3.718 ^==> GROSS UNCONFIRMED KIDNEYS 1.95 0.611 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.57 0.179 5,12 LUNGS 1.43 0.448 ^==> GROSS UNCONFIRMED OVARIES 0.1067 0.033 LUNGS MICRO: MINERALIZATION, VASCULAR 1 PITUITARY 0.0169 0.005 UTERUS MICRO: IMPLANTATION SITE P FINAL BODY WT(G) 319. UNILATERAL NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:MAMMARY GLAND OVARIES PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 854 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 53 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91652 GROUP 5: 10000 PPM FEMALE SCHEDULED EUTH 11/23/13 DATE OF DEATH: 11/23/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.94 0.546 6,8 LIVER 14.76 4.158 ^==> GROSS UNCONFIRMED KIDNEYS 2.46 0.693 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.97 0.273 7,8 LUNGS 1.52 0.428 ^==> GROSS UNCONFIRMED OVARIES 0.1185 0.033 LUNGS MICRO: MINERALIZATION, VASCULAR 1 PITUITARY 0.0180 0.005 UTERUS MICRO: IMPLANTATION SITE P FINAL BODY WT(G) 355. BILATERAL NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:MAMMARY GLAND OVARIES PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 855 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 54 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91655 GROUP 5: 10000 PPM FEMALE SCHEDULED EUTH 11/23/13 DATE OF DEATH: 11/23/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.96 0.618 9,6 LIVER 14.16 4.467 ^==> GROSS UNCONFIRMED KIDNEYS 2.57 0.811 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.91 0.287 9,6 LUNGS 1.52 0.479 ^==> GROSS UNCONFIRMED OVARIES 0.1034 0.033 UTERUS MICRO: IMPLANTATION SITE P PITUITARY 0.0141 0.004 BILATERAL FINAL BODY WT(G) 317. NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 856 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 55 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91658 GROUP 5: 10000 PPM FEMALE SCHEDULED EUTH 11/24/13 DATE OF DEATH: 11/24/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P BRAIN 1.96 0.603 7,8 LIVER 13.86 4.265 ^==> GROSS UNCONFIRMED KIDNEYS 2.17 0.668 GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P SPLEEN 0.63 0.194 7,8 LUNGS 1.28 0.394 ^==> GROSS UNCONFIRMED OVARIES 0.0901 0.028 UTERUS MICRO: IMPLANTATION SITE P PITUITARY 0.0161 0.005 BILATERAL FINAL BODY WT(G) 325. NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 857 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 56 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91667 GROUP 5: 10000 PPM FEMALE SCHEDULED EUTH 11/24/13 DATE OF DEATH: 11/24/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.89 0.543 6,10 LIVER 14.53 4.175 ^==> GROSS UNCONFIRMED KIDNEYS 2.31 0.664 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.60 0.172 9,11 LUNGS 1.33 0.382 ^==> GROSS UNCONFIRMED OVARIES 0.1316 0.038 UTERUS MICRO: IMPLANTATION SITE P PITUITARY 0.0192 0.006 BILATERAL FINAL BODY WT(G) 348. NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 858 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 57 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91668 GROUP 5: 10000 PPM FEMALE SCHEDULED EUTH 11/24/13 DATE OF DEATH: 11/24/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 2.06 0.602 5,10 LIVER 14.59 4.266 ^==> GROSS UNCONFIRMED KIDNEYS 2.65 0.775 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 1.31 0.383 5,12 LUNGS 1.60 0.468 ^==> GROSS UNCONFIRMED OVARIES 0.1886 0.055 SPLEEN MICRO: HEMATOPOIESIS, EXTRAMEDULLARY, INCREASED 2 PITUITARY 0.0161 0.005 UTERUS MICRO: IMPLANTATION SITE P FINAL BODY WT(G) 342. BILATERAL NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING**Page 859 of 1107**TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 58 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91680 GROUP 5: 10000 PPM FEMALE SCHEDULED EUTH 11/23/13 DATE OF DEATH: 11/23/13 GRADE

----------------------------------------------------------------------------------------------------------------------------------- ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P BRAIN 1.93 0.594 8,7 LIVER 13.70 4.215 ^==> GROSS UNCONFIRMED KIDNEYS 2.00 0.615 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P SPLEEN 0.56 0.172 8,7 LUNGS 1.54 0.474 ^==> GROSS UNCONFIRMED OVARIES 0.1366 0.042 LUNGS MICRO: MINERALIZATION, VASCULAR 2 PITUITARY 0.0190 0.006 PITUITARY MICRO: NO SIGNIFICANT CHANGES OBSERVED FINAL BODY WT(G) 325. PARS DISTALIS ONLY SPLEEN MICRO: NO SIGNIFICANT CHANGES OBSERVED NORMAL, BUT LARGE ON SUBGROSS UTERUS MICRO: IMPLANTATION SITE P BILATERAL NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES HEART INTESTINE KIDNEYS LIVER LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS OVARIES PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND SKIN SPLEEN STOMACH THYMUS THYROID GLANDS TRACHEA URINARY BLADDER UTERUS CERVIX VAGINA DIAPHRAGM MICRO:MAMMARY GLAND OVARIES PITUITARY SPLEEN CERVIX VAGINA

GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING PGRHv4.68 02/18/2014**Page 860 of 1107**TABLE A43 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CORPORA LUTEA AND IMPLANTATION SITES

0 PPM DAM IMPLANTATION PUPS UNACCOUNTED CORPORA NO. SITES BORN SITES LUTEA

----------------------------------------------------------------------------------------------------------------------------------- 91629 16 16 0 16 91630 16 14 2 16 91633 16 15 1 17 91637 15 13 2 15 91639 17 10 7 20 91644 18 17 1 18 91645 16 16 0 16 91648 14 14 0 15 91653 17 15 2 17 91660 15 14 1 18 91670 14 14 0 14 91672 16 14 2 16

----------------------------------------------------------------------------------------------------------------------------------- MEAN 15.8 14.3 1.5 16.5 S.D. 1.19 1.78 1.93 1.62 S.E. 0.34 0.51 0.56 0.47 N 12 12 12 12 NOTE: ONLY DAMS THAT HAVE DELIVERED ONE OR MORE PUPS ARE INCLUDED IN CALCULATION OF MEAN.**Page 861 of 1107**TABLE A43 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CORPORA LUTEA AND IMPLANTATION SITES

50 PPM DAM IMPLANTATION PUPS UNACCOUNTED CORPORA NO. SITES BORN SITES LUTEA

----------------------------------------------------------------------------------------------------------------------------------- 91632 15 15 0 16 91640 14 12 2 17 91642 15 15 0 16 91647 13 13 0 13 91651 14 12 2 14 91659 14 13 1 14 91661 17 17 0 17 91663 15 15 0 15 91669 16 16 0 16 91673 16 16 0 16 91683 13 12 1 14 91685 10 10 0 16

----------------------------------------------------------------------------------------------------------------------------------- MEAN 14.3 13.8 0.5 15.3 S.D. 1.83 2.12 0.80 1.30 S.E. 0.53 0.61 0.23 0.38 N 12 12 12 12 NOTE: ONLY DAMS THAT HAVE DELIVERED ONE OR MORE PUPS ARE INCLUDED IN CALCULATION OF MEAN.**Page 862 of 1107**TABLE A43 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CORPORA LUTEA AND IMPLANTATION SITES

100 PPM DAM IMPLANTATION PUPS UNACCOUNTED CORPORA NO. SITES BORN SITES LUTEA

----------------------------------------------------------------------------------------------------------------------------------- 91620 15 14 1 15 91628 15 15 0 15 91631 15 15 0 19 91636 16 13 3 16 91649 16 16 0 16 91650 14 14 0 15 91656 16 15 1 17 91671 15 15 0 15 91675 14 14 0 14 91677 6 5 1 16 91679 15 12 3 15 91684 16 16 0 16

----------------------------------------------------------------------------------------------------------------------------------- MEAN 14.4 13.7 0.8 15.8 S.D. 2.75 2.96 1.14 1.29 S.E. 0.79 0.86 0.33 0.37 N 12 12 12 12 NOTE: ONLY DAMS THAT HAVE DELIVERED ONE OR MORE PUPS ARE INCLUDED IN CALCULATION OF MEAN.**Page 863 of 1107**TABLE A43 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CORPORA LUTEA AND IMPLANTATION SITES

175 PPM DAM IMPLANTATION PUPS UNACCOUNTED CORPORA NO. SITES BORN SITES LUTEA

----------------------------------------------------------------------------------------------------------------------------------- 91622 15 14 1 15 91626 15 14 1 15 91643 15 12 3 18 91654 19 18 1 19 91657 16 13 3 17 91662 15 11 4 18 91666 12 11 1 13 91676 14 11 3 14 91678 17 14 3 17 91681 15 15 0 15 91682 15 13 2 17

----------------------------------------------------------------------------------------------------------------------------------- MEAN 15.3 13.3 2.0 16.2 S.D. 1.74 2.10 1.26 1.89 S.E. 0.52 0.63 0.38 0.57 N 11 11 11 11 NOTE: ONLY DAMS THAT HAVE DELIVERED ONE OR MORE PUPS ARE INCLUDED IN CALCULATION OF MEAN.**Page 864 of 1107**TABLE A43 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CORPORA LUTEA AND IMPLANTATION SITES

10000 PPM DAM IMPLANTATION PUPS UNACCOUNTED CORPORA NO. SITES BORN SITES LUTEA

----------------------------------------------------------------------------------------------------------------------------------- 91624 17 13 4 18 91625 14 14 0 16 91627 12-A 13 A 12-A 91634 15 13 2 17 91635 14 13 1 15 91638 16 16 0 17 91652 14 13 1 15 91655 15 13 2 15 91658 15 13 2 15 91667 16 16 0 20 91668 15 15 0 17 91680 15 15 0 15

----------------------------------------------------------------------------------------------------------------------------------- MEAN 15.1 13.9 1.1 16.4 S.D. 0.94 1.24 1.30 1.63 S.E. 0.28 0.36 0.39 0.49 N 11 12 11 11 NOTE: ONLY DAMS THAT HAVE DELIVERED ONE OR MORE PUPS ARE INCLUDED IN CALCULATION OF MEAN. A = NUMBER OF PUPS BORN EXCEEDED NUMBER OF IMPLANTATION SITES; VALUE NOT INCLUDED IN CALCULATION OF MEAN PIISv4.12 01/07/2014 R:01/21/2014**Page 865 of 1107**TABLE A44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]

MALE GROUP: 0 PPM

----------------------------------------------------------------------------------------------------------------------------------- TESTI ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS S, RT

----------------------------------------------------------------------------------------------------------------------------------- 91555 460. 2.16 14.72 3.45 0.85 1.62 1.50 91560 458. 2.23 15.81 3.54 0.87 1.88 1.70 91562 430. 2.05 16.66 3.28 0.82 1.40 1.62 91563 414. 2.08 14.49 3.32 0.70 1.68 1.67 91564 424. 2.10 14.20 3.56 0.66 1.65 1.68 91567 411. 1.86 15.57 3.23 0.74 1.41 1.59 91579 468. 2.17 17.75 3.26 0.90 1.78 1.66 91586 458. 2.12 16.47 3.42 0.94 1.75 1.63 91591 456. 2.11 14.86 3.35 0.77 1.75 1.69 91592 507. 2.28 17.30 3.44 1.06 1.86 1.79 91609 442. 2.16 15.38 3.52 0.71 1.44 1.86 91615 469. 2.15 16.54 3.26 0.79 1.68 1.63

MEAN 450. 2.12 15.81 3.39 0.82 1.66 1.67 S.D. 27.2 0.104 1.142 0.118 0.114 0.165 0.092 S.E. 7.9 0.030 0.330 0.034 0.033 0.048 0.027 N 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT**Page 866 of 1107**TABLE A44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]

MALE GROUP: 50 PPM

----------------------------------------------------------------------------------------------------------------------------------- TESTI ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS S, RT

----------------------------------------------------------------------------------------------------------------------------------- 91556 447. 1.94 14.68 3.07 0.67 1.57 1.68 91559 428. 1.95 16.22 3.46 0.85 1.89 1.77 91561 455. 2.09 16.27 3.46 0.86 1.80 1.68 91566 428. 1.87 14.61 3.24 0.72 1.48 1.71 91576 413. 2.09 14.82 3.37 0.79 1.42 1.66 91582 513. 2.14 18.93 3.94 1.01 1.70 1.94 91585 500. 2.04 21.23 3.98 1.04 1.79 1.67 91589 416. 2.02 13.44 2.92 0.69 1.72 1.60 91593 456. 2.17 16.35 3.49 0.96 1.63 1.41 91594 452. 2.07 16.00 2.98 0.74 2.02 1.67 91595 478. 2.19 17.08 3.04 0.92 1.82 1.66 91602 482. 1.89 16.87 3.65 0.79 1.70 1.80

MEAN 456. 2.04 16.38 3.38 0.84 1.71 1.69 S.D. 32.3 0.107 2.090 0.353 0.125 0.170 0.125 S.E. 9.3 0.031 0.603 0.102 0.036 0.049 0.036 N 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT**Page 867 of 1107**TABLE A44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]

MALE GROUP: 100 PPM

----------------------------------------------------------------------------------------------------------------------------------- TESTI ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS S, RT

----------------------------------------------------------------------------------------------------------------------------------- 91569 430. 2.06 14.10 2.81 0.89 1.60 1.61 91573 414. 2.16 15.39 3.27 0.75 1.47 1.86 91577 409. 2.02 14.70 3.19 0.68 1.84 1.55 91581 439. 2.07 15.67 3.32 0.72 1.78 1.63 91583 407. 2.02 14.21 2.97 0.75 1.71 1.75 91588 453. 1.99 17.58 3.60 0.71 1.66 1.85 91590 448. 2.18 15.06 3.15 0.80 1.61 1.54 91598 412. 1.97 14.00 3.45 0.74 1.74 1.54 91599 416. 2.02 15.92 3.13 0.77 1.64 1.52 91608 445. 2.03 14.49 3.35 0.79 1.80 1.75 91611 441. 1.95 15.63 3.35 0.74 1.67 1.70 91616 454. 2.07 16.80 3.33 0.78 1.74 1.76

MEAN 431. 2.05 15.30 3.24 0.76 1.69 1.67 S.D. 18.1 0.069 1.107 0.212 0.053 0.102 0.123 S.E. 5.2 0.020 0.320 0.061 0.015 0.029 0.035 N 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT**Page 868 of 1107**TABLE A44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]

MALE GROUP: 175 PPM

----------------------------------------------------------------------------------------------------------------------------------- TESTI ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS S, RT

----------------------------------------------------------------------------------------------------------------------------------- 91565 408. 2.06 14.18 2.94 0.68 1.67 1.47 91568 439. 1.99 16.32 3.81 0.68 1.70 1.63 91570 425. 1.91 14.48 3.20 0.86 1.67 1.64 91572 427. 2.09 16.20 3.26 0.83 1.91 1.71 91580 414. 2.00 14.26 3.32 0.60 1.87 1.71 91584 427. 2.02 15.90 3.19 0.73 1.73 1.74 91587 472. 2.03 17.64 3.65 0.99 2.01 1.90 91597 425. 1.91 14.18 3.31 0.77 2.01 1.74 91601 430. 2.04 15.22 3.32 0.84 1.61 1.62 91607 468. 2.17 16.16 3.16 0.86 1.85 1.79 91613 451. 1.99 15.45 3.22 0.77 2.01 1.56 91614 464. 1.97 16.89 3.74 0.67 1.57 1.71

MEAN 438. 2.02 15.57 3.34 0.77 1.80 1.69 S.D. 21.4 0.073 1.142 0.258 0.109 0.162 0.111 S.E. 6.2 0.021 0.330 0.075 0.031 0.047 0.032 N 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT**Page 869 of 1107**TABLE A44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]

MALE GROUP: 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- TESTI ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS S, RT

----------------------------------------------------------------------------------------------------------------------------------- 91554 413. 1.97 12.74 2.51 0.74 1.53 1.62 91557 459. 2.15 14.88 3.30 0.95 1.91 1.87 91558 423. 1.94 13.27 2.95 0.66 1.71 1.62 91571 381. 1.97 13.50 3.14 0.64 1.61 1.50 91575 443. 2.18 14.35 3.44 0.74 1.85 1.60 91600 448. 2.13 15.48 3.24 0.78 1.63 1.85 91603 412. 1.93 18.11 3.60 0.70 1.72 1.74 91604 432. 1.89 15.12 3.14 0.70 1.64 1.75 91605 400. 2.00 13.23 2.96 0.65 1.41 1.83 91612 388. 2.16 14.21 3.12 0.69 1.39 1.90 91618 409. 2.17 14.65 3.35 0.83 1.62 1.59 91619 410. 2.05 13.77 3.24 0.74 1.68 1.61

MEAN 418. 2.05 14.44 3.17 0.74 1.64 1.71 S.D. 23.8 0.107 1.426 0.278 0.087 0.153 0.133 S.E. 6.9 0.031 0.412 0.080 0.025 0.044 0.038 N 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT**Page 870 of 1107**TABLE A44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]

MALE GROUP: 0 PPM

----------------------------------------------------------------------------------------------------------------------------------- TESTI EPIDIDY CAUDA E PITU EPIDIDY CAUDA E ANIMAL S, LT MIS, LT PID, LT ITARY MIS, RT PID, RT

----------------------------------------------------------------------------------------------------------------------------------- 91555 1.52 0.58 0.2512 0.0178 0.59 0.2510 91560 1.69 0.60 0.2944 0.0149 0.64 0.2717 91562 1.56 0.57 0.2560 0.0133 0.62 0.2690 91563 1.65 0.55 0.2791 0.0142 0.64 0.2878 91564 1.64 0.56 0.2773 0.0178 0.62 0.2677 91567 1.59 0.55 0.2696 0.0102 0.62 0.2710 91579 1.66 0.63 0.2849 0.0179 0.61 0.2482 91586 1.61 0.57 0.2795 0.0227 0.67 0.2952 91591 1.70 0.55 0.2775 0.0136 0.60 0.2654 91592 1.76 0.63 0.3003 0.0148 0.67 0.2779 91609 1.78 0.69 0.3171 0.0145 0.72 0.3076 91615 1.64 0.60 0.3024 0.0159 0.66 0.2768

MEAN 1.65 0.59 0.2824 0.0156 0.64 0.2741 S.D. 0.076 0.043 0.01902 0.00314 0.037 0.01689 S.E. 0.022 0.012 0.00549 0.00091 0.011 0.00488 N 12 12 12 12 12 12**Page 871 of 1107**TABLE A44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]

MALE GROUP: 50 PPM

----------------------------------------------------------------------------------------------------------------------------------- TESTI EPIDIDY CAUDA E PITU EPIDIDY CAUDA E ANIMAL S, LT MIS, LT PID, LT ITARY MIS, RT PID, RT

----------------------------------------------------------------------------------------------------------------------------------- 91556 1.67 0.64 0.2826 0.0126 0.68 0.2840 91559 1.79 0.59 0.2970 0.0143 0.62 0.2438 91561 1.61 0.68 0.3222 0.0176 0.69 0.3183 91566 1.73 0.61 0.2596 0.0120 0.67 0.2544 91576 1.67 0.60 0.2934 0.0134 0.64 0.3055 91582 1.90 0.64 0.3067 0.0162 0.70 0.2774 91585 1.72 0.67 0.2929 0.0174 0.69 0.2850 91589 1.53 0.54 0.2590 0.0129 0.57 0.2568 91593 1.47 0.55 0.2649 0.0165 0.61 0.2732 91594 1.62 0.58 0.3126 0.0153 0.60 0.2789 91595 1.70 0.67 0.3439 0.0146 0.71 0.3060 91602 1.81 0.62 0.3050 0.0120 0.65 0.3072

MEAN 1.69 0.62 0.2950 0.0146 0.65 0.2825 S.D. 0.119 0.046 0.02576 0.00203 0.045 0.02346 S.E. 0.034 0.013 0.00744 0.00059 0.013 0.00677 N 12 12 12 12 12 12**Page 872 of 1107**TABLE A44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]

MALE GROUP: 100 PPM

----------------------------------------------------------------------------------------------------------------------------------- TESTI EPIDIDY CAUDA E PITU EPIDIDY CAUDA E ANIMAL S, LT MIS, LT PID, LT ITARY MIS, RT PID, RT

----------------------------------------------------------------------------------------------------------------------------------- 91569 1.48 0.54 0.2398 0.0103 0.56 0.2163 91573 1.86 0.65 0.2993 0.0134 0.73 0.3138 91577 1.57 0.53 0.2611 0.0105 0.57 0.2454 91581 1.59 0.59 0.3040 0.0125 0.64 0.2767 91583 1.74 0.61 0.2789 0.0119 0.66 0.2743 91588 1.85 0.63 0.2997 0.0125 0.64 0.3015 91590 1.55 0.57 0.2844 0.0151 0.63 0.2792 91598 1.55 0.57 0.2715 0.0136 0.59 0.2539 91599 1.52 0.56 0.2566 0.0123 0.60 0.2632 91608 1.76 0.57 0.2618 0.0117 0.64 0.2603 91611 1.68 0.66 0.3093 0.0130 0.66 0.2551 91616 1.81 0.58 0.2749 0.0141 0.66 0.2745

MEAN 1.66 0.59 0.2784 0.0126 0.63 0.2679 S.D. 0.136 0.041 0.02161 0.00139 0.047 0.02547 S.E. 0.039 0.012 0.00624 0.00040 0.013 0.00735 N 12 12 12 12 12 12**Page 873 of 1107**TABLE A44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]

MALE GROUP: 175 PPM

----------------------------------------------------------------------------------------------------------------------------------- TESTI EPIDIDY CAUDA E PITU EPIDIDY CAUDA E ANIMAL S, LT MIS, LT PID, LT ITARY MIS, RT PID, RT

----------------------------------------------------------------------------------------------------------------------------------- 91565 1.41 0.53 0.2525 0.0106 0.59 0.2524 91568 1.60 0.62 0.2921 0.0140 0.62 0.2490 91570 1.68 0.61 0.2583 0.0124 0.64 0.2848 91572 1.65 0.60 0.2723 0.0121 0.63 0.2798 91580 1.72 0.58 0.2866 0.0126 0.56 0.2404 91584 1.74 0.66 0.2757 0.0138 0.62 0.2533 91587 1.87 0.66 0.3195 0.0135 0.66 0.2723 91597 1.75 0.59 0.2668 0.0113 0.66 0.2745 91601 1.59 0.60 0.2826 0.0119 0.62 0.2693 91607 1.69 0.62 0.2889 0.0132 0.71 0.2990 91613 1.56 0.56 0.2233 0.0144 0.61 0.2292 91614 1.65 0.68 0.3280 0.0128 0.71 0.3102

MEAN 1.66 0.61 0.2789 0.0127 0.64 0.2679 S.D. 0.115 0.043 0.02832 0.00113 0.044 0.02396 S.E. 0.033 0.012 0.00817 0.00033 0.013 0.00692 N 12 12 12 12 12 12**Page 874 of 1107**TABLE A44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]

MALE GROUP: 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- TESTI EPIDIDY CAUDA E PITU EPIDIDY CAUDA E ANIMAL S, LT MIS, LT PID, LT ITARY MIS, RT PID, RT

----------------------------------------------------------------------------------------------------------------------------------- 91554 1.52 0.63 0.2980 0.0130 0.57 0.2265 91557 1.88 0.62 0.2711 0.0159 0.66 0.2960 91558 1.58 0.55 0.2771 0.0107 0.62 0.2652 91571 1.50 0.55 0.2693 0.0125 0.58 0.2648 91575 1.55 0.56 0.2104 0.0122 0.59 0.2488 91600 1.72 0.64 0.3179 0.0132 0.73 0.3173 91603 1.73 0.66 0.2831 0.0123 0.68 0.2552 91604 1.71 0.64 0.2876 0.0149 0.68 0.2619 91605 1.86 0.60 0.3019 0.0127 0.61 0.2506 91612 1.86 0.66 0.3086 0.0134 0.74 0.2796 91618 1.55 0.58 0.2653 0.0157 0.63 0.2693 91619 1.62 0.53 0.2584 0.0131 0.56 0.2330

MEAN 1.67 0.60 0.2791 0.0133 0.64 0.2640 S.D. 0.140 0.046 0.02835 0.00151 0.061 0.02522 S.E. 0.040 0.013 0.00819 0.00044 0.018 0.00728 N 12 12 12 12 12 12

POFBWv4.31 11/25/2013 R:01/17/2014**Page 875 of 1107**TABLE A45 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]

MALE GROUP: 0 PPM

----------------------------------------------------------------------------------------------------------------------------------- TESTI ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS S, RT

----------------------------------------------------------------------------------------------------------------------------------- 91555 460. 0.470 3.200 0.750 0.185 0.352 0.326 91560 458. 0.487 3.452 0.773 0.190 0.410 0.371 91562 430. 0.477 3.874 0.763 0.191 0.326 0.377 91563 414. 0.502 3.500 0.802 0.169 0.406 0.403 91564 424. 0.495 3.349 0.840 0.156 0.389 0.396 91567 411. 0.453 3.788 0.786 0.180 0.343 0.387 91579 468. 0.464 3.793 0.697 0.192 0.380 0.355 91586 458. 0.463 3.596 0.747 0.205 0.382 0.356 91591 456. 0.463 3.259 0.735 0.169 0.384 0.371 91592 507. 0.450 3.412 0.679 0.209 0.367 0.353 91609 442. 0.489 3.480 0.796 0.161 0.326 0.421 91615 469. 0.458 3.527 0.695 0.168 0.358 0.348

MEAN 450. 0.472 3.519 0.755 0.181 0.369 0.372 S.D. 27.2 0.0173 0.2123 0.0484 0.0170 0.0283 0.0267 S.E. 7.9 0.0050 0.0613 0.0140 0.0049 0.0082 0.0077 N 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT**Page 876 of 1107**TABLE A45 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]

MALE GROUP: 50 PPM

----------------------------------------------------------------------------------------------------------------------------------- TESTI ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS S, RT

----------------------------------------------------------------------------------------------------------------------------------- 91556 447. 0.434 3.284 0.687 0.150 0.351 0.376 91559 428. 0.456 3.790 0.808 0.199 0.442 0.414 91561 455. 0.459 3.576 0.760 0.189 0.396 0.369 91566 428. 0.437 3.414 0.757 0.168 0.346 0.400 91576 413. 0.506 3.588 0.816 0.191 0.344 0.402 91582 513. 0.417 3.690 0.768 0.197 0.331 0.378 91585 500. 0.408 4.246 0.796 0.208 0.358 0.334 91589 416. 0.486 3.231 0.702 0.166 0.413 0.385 91593 456. 0.476 3.586 0.765 0.211 0.357 0.309 91594 452. 0.458 3.540 0.659 0.164 0.447 0.369 91595 478. 0.458 3.573 0.636 0.192 0.381 0.347 91602 482. 0.392 3.500 0.757 0.164 0.353 0.373

MEAN 456. 0.449 3.585 0.743 0.183 0.377 0.371 S.D. 32.3 0.0329 0.2602 0.0584 0.0199 0.0392 0.0295 S.E. 9.3 0.0095 0.0751 0.0169 0.0057 0.0113 0.0085 N 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT**Page 877 of 1107**TABLE A45 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]

MALE GROUP: 100 PPM

----------------------------------------------------------------------------------------------------------------------------------- TESTI ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS S, RT

----------------------------------------------------------------------------------------------------------------------------------- 91569 430. 0.479 3.279 0.653 0.207 0.372 0.374 91573 414. 0.522 3.717 0.790 0.181 0.355 0.449 91577 409. 0.494 3.594 0.780 0.166 0.450 0.379 91581 439. 0.472 3.569 0.756 0.164 0.405 0.371 91583 407. 0.496 3.491 0.730 0.184 0.420 0.430 91588 453. 0.439 3.881 0.795 0.157 0.366 0.408 91590 448. 0.487 3.362 0.703 0.179 0.359 0.344 91598 412. 0.478 3.398 0.837 0.180 0.422 0.374 91599 416. 0.486 3.827 0.752 0.185 0.394 0.365 91608 445. 0.456 3.256 0.753 0.178 0.404 0.393 91611 441. 0.442 3.544 0.760 0.168 0.379 0.385 91616 454. 0.456 3.700 0.733 0.172 0.383 0.388

MEAN 431. 0.476 3.552 0.754 0.177 0.393 0.388 S.D. 18.1 0.0240 0.2047 0.0470 0.0130 0.0288 0.0289 S.E. 5.2 0.0069 0.0591 0.0136 0.0037 0.0083 0.0083 N 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT**Page 878 of 1107**TABLE A45 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]

MALE GROUP: 175 PPM

----------------------------------------------------------------------------------------------------------------------------------- TESTI ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS S, RT

----------------------------------------------------------------------------------------------------------------------------------- 91565 408. 0.505 3.475 0.721 0.167 0.409 0.360 91568 439. 0.453 3.718 0.868 0.155 0.387 0.371 91570 425. 0.449 3.407 0.753 0.202 0.393 0.386 91572 427. 0.489 3.794 0.763 0.194 0.447 0.400 91580 414. 0.483 3.444 0.802 0.145 0.452 0.413 91584 427. 0.473 3.724 0.747 0.171 0.405 0.407 91587 472. 0.430 3.737 0.773 0.210 0.426 0.403 91597 425. 0.449 3.336 0.779 0.181 0.473 0.409 91601 430. 0.474 3.540 0.772 0.195 0.374 0.377 91607 468. 0.464 3.453 0.675 0.184 0.395 0.382 91613 451. 0.441 3.426 0.714 0.171 0.446 0.346 91614 464. 0.425 3.640 0.806 0.144 0.338 0.369

MEAN 438. 0.461 3.558 0.764 0.177 0.412 0.385 S.D. 21.4 0.0244 0.1560 0.0496 0.0217 0.0381 0.0215 S.E. 6.2 0.0070 0.0450 0.0143 0.0063 0.0110 0.0062 N 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT**Page 879 of 1107**TABLE A45 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]

MALE GROUP: 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- TESTI ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS S, RT

----------------------------------------------------------------------------------------------------------------------------------- 91554 413. 0.477 3.085 0.608 0.179 0.370 0.392 91557 459. 0.468 3.242 0.719 0.207 0.416 0.407 91558 423. 0.459 3.137 0.697 0.156 0.404 0.383 91571 381. 0.517 3.543 0.824 0.168 0.423 0.394 91575 443. 0.492 3.239 0.777 0.167 0.418 0.361 91600 448. 0.475 3.455 0.723 0.174 0.364 0.413 91603 412. 0.468 4.396 0.874 0.170 0.417 0.422 91604 432. 0.438 3.500 0.727 0.162 0.380 0.405 91605 400. 0.500 3.307 0.740 0.162 0.352 0.458 91612 388. 0.557 3.662 0.804 0.178 0.358 0.490 91618 409. 0.531 3.582 0.819 0.203 0.396 0.389 91619 410. 0.500 3.359 0.790 0.180 0.410 0.393

MEAN 418. 0.490 3.459 0.759 0.176 0.392 0.409 S.D. 23.8 0.0331 0.3457 0.0709 0.0156 0.0260 0.0347 S.E. 6.9 0.0096 0.0998 0.0205 0.0045 0.0075 0.0100 N 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT**Page 880 of 1107**TABLE A45 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]

MALE GROUP: 0 PPM

----------------------------------------------------------------------------------------------------------------------------------- TESTI EPIDIDY CAUDA E PITU EPIDIDY CAUDA E ANIMAL S, LT MIS, LT PID, LT ITARY MIS, RT PID, RT

----------------------------------------------------------------------------------------------------------------------------------- 91555 0.330 0.126 0.055 0.004 0.128 0.055 91560 0.369 0.131 0.064 0.003 0.140 0.059 91562 0.363 0.133 0.060 0.003 0.144 0.063 91563 0.399 0.133 0.067 0.003 0.155 0.070 91564 0.387 0.132 0.065 0.004 0.146 0.063 91567 0.387 0.134 0.066 0.002 0.151 0.066 91579 0.355 0.135 0.061 0.004 0.130 0.053 91586 0.352 0.124 0.061 0.005 0.146 0.064 91591 0.373 0.121 0.061 0.003 0.132 0.058 91592 0.347 0.124 0.059 0.003 0.132 0.055 91609 0.403 0.156 0.072 0.003 0.163 0.070 91615 0.350 0.128 0.064 0.003 0.141 0.059

MEAN 0.368 0.131 0.063 0.003 0.142 0.061 S.D. 0.0224 0.0090 0.0045 0.0007 0.0107 0.0057 S.E. 0.0065 0.0026 0.0013 0.0002 0.0031 0.0016 N 12 12 12 12 12 12**Page 881 of 1107**TABLE A45 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]

MALE GROUP: 50 PPM

----------------------------------------------------------------------------------------------------------------------------------- TESTI EPIDIDY CAUDA E PITU EPIDIDY CAUDA E ANIMAL S, LT MIS, LT PID, LT ITARY MIS, RT PID, RT

----------------------------------------------------------------------------------------------------------------------------------- 91556 0.374 0.143 0.063 0.003 0.152 0.064 91559 0.418 0.138 0.069 0.003 0.145 0.057 91561 0.354 0.149 0.071 0.004 0.152 0.070 91566 0.404 0.143 0.061 0.003 0.157 0.059 91576 0.404 0.145 0.071 0.003 0.155 0.074 91582 0.370 0.125 0.060 0.003 0.136 0.054 91585 0.344 0.134 0.059 0.003 0.138 0.057 91589 0.368 0.130 0.062 0.003 0.137 0.062 91593 0.322 0.121 0.058 0.004 0.134 0.060 91594 0.358 0.128 0.069 0.003 0.133 0.062 91595 0.356 0.140 0.072 0.003 0.149 0.064 91602 0.376 0.129 0.063 0.002 0.135 0.064

MEAN 0.371 0.135 0.065 0.003 0.143 0.062 S.D. 0.0274 0.0090 0.0053 0.0004 0.0089 0.0056 S.E. 0.0079 0.0026 0.0015 0.0001 0.0026 0.0016 N 12 12 12 12 12 12**Page 882 of 1107**TABLE A45 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]

MALE GROUP: 100 PPM

----------------------------------------------------------------------------------------------------------------------------------- TESTI EPIDIDY CAUDA E PITU EPIDIDY CAUDA E ANIMAL S, LT MIS, LT PID, LT ITARY MIS, RT PID, RT

----------------------------------------------------------------------------------------------------------------------------------- 91569 0.344 0.126 0.056 0.002 0.130 0.050 91573 0.449 0.157 0.072 0.003 0.176 0.076 91577 0.384 0.130 0.064 0.003 0.139 0.060 91581 0.362 0.134 0.069 0.003 0.146 0.063 91583 0.428 0.150 0.069 0.003 0.162 0.067 91588 0.408 0.139 0.066 0.003 0.141 0.067 91590 0.346 0.127 0.063 0.003 0.141 0.062 91598 0.376 0.138 0.066 0.003 0.143 0.062 91599 0.365 0.135 0.062 0.003 0.144 0.063 91608 0.396 0.128 0.059 0.003 0.144 0.058 91611 0.381 0.150 0.070 0.003 0.150 0.058 91616 0.399 0.128 0.061 0.003 0.145 0.060

MEAN 0.387 0.137 0.065 0.003 0.147 0.062 S.D. 0.0315 0.0104 0.0049 0.0003 0.0119 0.0063 S.E. 0.0091 0.0030 0.0014 0.0001 0.0034 0.0018 N 12 12 12 12 12 12**Page 883 of 1107**TABLE A45 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]

MALE GROUP: 175 PPM

----------------------------------------------------------------------------------------------------------------------------------- TESTI EPIDIDY CAUDA E PITU EPIDIDY CAUDA E ANIMAL S, LT MIS, LT PID, LT ITARY MIS, RT PID, RT

----------------------------------------------------------------------------------------------------------------------------------- 91565 0.346 0.130 0.062 0.003 0.145 0.062 91568 0.364 0.141 0.067 0.003 0.141 0.057 91570 0.395 0.144 0.061 0.003 0.151 0.067 91572 0.386 0.141 0.064 0.003 0.148 0.066 91580 0.415 0.140 0.069 0.003 0.135 0.058 91584 0.407 0.155 0.065 0.003 0.145 0.059 91587 0.396 0.140 0.068 0.003 0.140 0.058 91597 0.412 0.139 0.063 0.003 0.155 0.065 91601 0.370 0.140 0.066 0.003 0.144 0.063 91607 0.361 0.132 0.062 0.003 0.152 0.064 91613 0.346 0.124 0.050 0.003 0.135 0.051 91614 0.356 0.147 0.071 0.003 0.153 0.067

MEAN 0.380 0.139 0.064 0.003 0.145 0.061 S.D. 0.0256 0.0078 0.0054 0.0002 0.0066 0.0049 S.E. 0.0074 0.0023 0.0016 0.0001 0.0019 0.0014 N 12 12 12 12 12 12**Page 884 of 1107**TABLE A45 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]

MALE GROUP: 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- TESTI EPIDIDY CAUDA E PITU EPIDIDY CAUDA E ANIMAL S, LT MIS, LT PID, LT ITARY MIS, RT PID, RT

----------------------------------------------------------------------------------------------------------------------------------- 91554 0.368 0.153 0.072 0.003 0.138 0.055 91557 0.410 0.135 0.059 0.003 0.144 0.064 91558 0.374 0.130 0.066 0.003 0.147 0.063 91571 0.394 0.144 0.071 0.003 0.152 0.070 91575 0.350 0.126 0.047 0.003 0.133 0.056 91600 0.384 0.143 0.071 0.003 0.163 0.071 91603 0.420 0.160 0.069 0.003 0.165 0.062 91604 0.396 0.148 0.067 0.003 0.157 0.061 91605 0.465 0.150 0.075 0.003 0.153 0.063 91612 0.479 0.170 0.080 0.003 0.191 0.072 91618 0.379 0.142 0.065 0.004 0.154 0.066 91619 0.395 0.129 0.063 0.003 0.137 0.057

MEAN 0.401 0.144 0.067 0.003 0.153 0.063 S.D. 0.0382 0.0131 0.0083 0.0004 0.0157 0.0057 S.E. 0.0110 0.0038 0.0024 0.0001 0.0045 0.0016 N 12 12 12 12 12 12

POFBWv4.31 11/25/2013 R:01/17/2014**Page 885 of 1107**TABLE A46 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G]

MALE GROUP: 0 PPM

----------------------------------------------------------------------------------------------------------------------------------- BRAIN WT TESTI ANIMAL FBW(G) (GRAMS) LIVER KIDNEYS SPLEEN LUNGS S, RT

----------------------------------------------------------------------------------------------------------------------------------- 91555 460. 2.16 681.482 159.722 39.352 75.000 69.444 91560 458. 2.23 708.969 158.744 39.013 84.305 76.233 91562 430. 2.05 812.683 160.000 40.000 68.293 79.024 91563 414. 2.08 696.635 159.615 33.654 80.769 80.288 91564 424. 2.10 676.191 169.524 31.429 78.571 80.000 91567 411. 1.86 837.097 173.656 39.785 75.806 85.484 91579 468. 2.17 817.972 150.230 41.475 82.028 76.498 91586 458. 2.12 776.887 161.321 44.340 82.547 76.887 91591 456. 2.11 704.265 158.768 36.493 82.938 80.095 91592 507. 2.28 758.772 150.877 46.491 81.579 78.509 91609 442. 2.16 712.037 162.963 32.870 66.667 86.111 91615 469. 2.15 769.302 151.628 36.744 78.140 75.814

MEAN 450. 2.12 746.024 159.754 38.470 78.054 78.699 S.D. 27.2 0.104 56.6688 7.0004 4.5124 5.7074 4.4258 S.E. 7.9 0.030 16.3589 2.0209 1.3026 1.6476 1.2776 N 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT**Page 886 of 1107**TABLE A46 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G]

MALE GROUP: 50 PPM

----------------------------------------------------------------------------------------------------------------------------------- BRAIN WT TESTI ANIMAL FBW(G) (GRAMS) LIVER KIDNEYS SPLEEN LUNGS S, RT

----------------------------------------------------------------------------------------------------------------------------------- 91556 447. 1.94 756.701 158.247 34.536 80.928 86.598 91559 428. 1.95 831.795 177.436 43.590 96.923 90.769 91561 455. 2.09 778.469 165.550 41.148 86.124 80.383 91566 428. 1.87 781.283 173.262 38.503 79.144 91.444 91576 413. 2.09 709.091 161.244 37.799 67.943 79.426 91582 513. 2.14 884.579 184.112 47.196 79.439 90.654 91585 500. 2.04 1040.686 195.098 50.980 87.745 81.863 91589 416. 2.02 665.347 144.554 34.158 85.149 79.208 91593 456. 2.17 753.456 160.829 44.240 75.115 64.977 91594 452. 2.07 772.947 143.961 35.749 97.585 80.676 91595 478. 2.19 779.909 138.813 42.009 83.105 75.799 91602 482. 1.89 892.593 193.122 41.799 89.947 95.238

MEAN 456. 2.04 803.905 166.352 40.976 84.096 83.086 S.D. 32.3 0.107 98.5677 18.7974 5.1303 8.5177 8.3680 S.E. 9.3 0.031 28.4540 5.4263 1.4810 2.4588 2.4156 N 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT**Page 887 of 1107**TABLE A46 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G]

MALE GROUP: 100 PPM

----------------------------------------------------------------------------------------------------------------------------------- BRAIN WT TESTI ANIMAL FBW(G) (GRAMS) LIVER KIDNEYS SPLEEN LUNGS S, RT

----------------------------------------------------------------------------------------------------------------------------------- 91569 430. 2.06 684.466 136.408 43.204 77.670 78.155 91573 414. 2.16 712.500 151.389 34.722 68.056 86.111 91577 409. 2.02 727.723 157.921 33.663 91.089 76.733 91581 439. 2.07 757.005 160.386 34.783 85.990 78.744 91583 407. 2.02 703.465 147.030 37.129 84.653 86.634 91588 453. 1.99 883.417 180.905 35.678 83.417 92.965 91590 448. 2.18 690.826 144.495 36.697 73.853 70.642 91598 412. 1.97 710.660 175.127 37.563 88.325 78.173 91599 416. 2.02 788.119 154.951 38.119 81.188 75.248 91608 445. 2.03 713.793 165.025 38.916 88.670 86.207 91611 441. 1.95 801.538 171.795 37.949 85.641 87.179 91616 454. 2.07 811.594 160.870 37.681 84.058 85.024

MEAN 431. 2.05 748.759 158.858 37.175 82.718 81.818 S.D. 18.1 0.069 60.6455 13.0893 2.4830 6.6306 6.4261 S.E. 5.2 0.020 17.5068 3.7786 0.7168 1.9141 1.8551 N 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT**Page 888 of 1107**TABLE A46 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G]

MALE GROUP: 175 PPM

----------------------------------------------------------------------------------------------------------------------------------- BRAIN WT TESTI ANIMAL FBW(G) (GRAMS) LIVER KIDNEYS SPLEEN LUNGS S, RT

----------------------------------------------------------------------------------------------------------------------------------- 91565 408. 2.06 688.350 142.718 33.010 81.068 71.359 91568 439. 1.99 820.101 191.457 34.171 85.427 81.910 91570 425. 1.91 758.115 167.539 45.026 87.435 85.864 91572 427. 2.09 775.120 155.981 39.713 91.388 81.818 91580 414. 2.00 713.000 166.000 30.000 93.500 85.500 91584 427. 2.02 787.129 157.921 36.139 85.644 86.139 91587 472. 2.03 868.966 179.803 48.768 99.015 93.596 91597 425. 1.91 742.408 173.298 40.314 105.236 91.099 91601 430. 2.04 746.078 162.745 41.176 78.922 79.412 91607 468. 2.17 744.700 145.622 39.631 85.253 82.488 91613 451. 1.99 776.382 161.809 38.693 101.005 78.392 91614 464. 1.97 857.360 189.848 34.010 79.695 86.802

MEAN 438. 2.02 773.142 166.229 38.388 89.466 83.698 S.D. 21.4 0.073 54.1115 15.4138 5.2915 8.6495 5.9026 S.E. 6.2 0.021 15.6206 4.4496 1.5275 2.4969 1.7039 N 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT**Page 889 of 1107**TABLE A46 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G]

MALE GROUP: 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- BRAIN WT TESTI ANIMAL FBW(G) (GRAMS) LIVER KIDNEYS SPLEEN LUNGS S, RT

----------------------------------------------------------------------------------------------------------------------------------- 91554 413. 1.97 646.701 127.411 37.563 77.665 82.234 91557 459. 2.15 692.093 153.488 44.186 88.837 86.977 91558 423. 1.94 684.021 152.062 34.021 88.144 83.505 91571 381. 1.97 685.279 159.391 32.487 81.726 76.142 91575 443. 2.18 658.257 157.798 33.945 84.862 73.394 91600 448. 2.13 726.760 152.113 36.620 76.526 86.854 91603 412. 1.93 938.342 186.529 36.269 89.119 90.155 91604 432. 1.89 800.000 166.138 37.037 86.772 92.593 91605 400. 2.00 661.500 148.000 32.500 70.500 91.500 91612 388. 2.16 657.870 144.444 31.944 64.352 87.963 91618 409. 2.17 675.115 154.378 38.249 74.654 73.272 91619 410. 2.05 671.707 158.049 36.098 81.951 78.537

MEAN 418. 2.05 708.137 154.983 35.910 80.426 83.594 S.D. 23.8 0.107 83.4066 13.8028 3.3728 7.8793 6.8837 S.E. 6.9 0.031 24.0774 3.9845 0.9736 2.2746 1.9871 N 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT**Page 890 of 1107**TABLE A46 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G]

MALE GROUP: 0 PPM

----------------------------------------------------------------------------------------------------------------------------------- TESTI EPIDIDY CAUDA E PITU EPIDIDY CAUDA E ANIMAL S, LT MIS, LT PID, LT ITARY MIS, RT PID, RT

----------------------------------------------------------------------------------------------------------------------------------- 91555 70.370 26.852 11.630 0.824 27.315 11.620 91560 75.785 26.906 13.202 0.668 28.700 12.184 91562 76.098 27.805 12.488 0.649 30.244 13.122 91563 79.327 26.442 13.418 0.683 30.769 13.837 91564 78.095 26.667 13.205 0.848 29.524 12.748 91567 85.484 29.570 14.495 0.548 33.333 14.570 91579 76.498 29.032 13.129 0.825 28.111 11.438 91586 75.943 26.887 13.184 1.071 31.604 13.925 91591 80.569 26.066 13.152 0.645 28.436 12.578 91592 77.193 27.632 13.171 0.649 29.386 12.189 91609 82.407 31.944 14.681 0.671 33.333 14.241 91615 76.279 27.907 14.065 0.740 30.698 12.874

MEAN 77.837 27.809 13.318 0.735 30.121 12.944 S.D. 3.8177 1.6660 0.8245 0.1383 1.9371 1.0209 S.E. 1.1021 0.4809 0.2380 0.0399 0.5592 0.2947 N 12 12 12 12 12 12**Page 891 of 1107**TABLE A46 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G]

MALE GROUP: 50 PPM

----------------------------------------------------------------------------------------------------------------------------------- TESTI EPIDIDY CAUDA E PITU EPIDIDY CAUDA E ANIMAL S, LT MIS, LT PID, LT ITARY MIS, RT PID, RT

----------------------------------------------------------------------------------------------------------------------------------- 91556 86.082 32.990 14.567 0.649 35.052 14.639 91559 91.795 30.256 15.231 0.733 31.795 12.503 91561 77.034 32.536 15.416 0.842 33.014 15.230 91566 92.513 32.620 13.882 0.642 35.829 13.604 91576 79.904 28.708 14.038 0.641 30.622 14.617 91582 88.785 29.907 14.332 0.757 32.710 12.963 91585 84.314 32.843 14.358 0.853 33.824 13.971 91589 75.743 26.733 12.822 0.639 28.218 12.713 91593 67.742 25.346 12.207 0.760 28.111 12.590 91594 78.261 28.019 15.101 0.739 28.986 13.473 91595 77.626 30.594 15.703 0.667 32.420 13.973 91602 95.767 32.804 16.138 0.635 34.392 16.254

MEAN 82.964 30.280 14.483 0.713 32.081 13.878 S.D. 8.2986 2.6216 1.1513 0.0795 2.6131 1.1520 S.E. 2.3956 0.7568 0.3324 0.0230 0.7543 0.3326 N 12 12 12 12 12 12**Page 892 of 1107**TABLE A46 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G]

MALE GROUP: 100 PPM

----------------------------------------------------------------------------------------------------------------------------------- TESTI EPIDIDY CAUDA E PITU EPIDIDY CAUDA E ANIMAL S, LT MIS, LT PID, LT ITARY MIS, RT PID, RT

----------------------------------------------------------------------------------------------------------------------------------- 91569 71.845 26.214 11.641 0.500 27.184 10.500 91573 86.111 30.093 13.856 0.620 33.796 14.528 91577 77.723 26.238 12.926 0.520 28.218 12.149 91581 76.812 28.502 14.686 0.604 30.918 13.367 91583 86.139 30.198 13.807 0.589 32.673 13.579 91588 92.965 31.658 15.060 0.628 32.161 15.151 91590 71.101 26.147 13.046 0.693 28.899 12.807 91598 78.680 28.934 13.782 0.690 29.949 12.888 91599 75.248 27.723 12.703 0.609 29.703 13.030 91608 86.700 28.079 12.897 0.576 31.527 12.823 91611 86.154 33.846 15.862 0.667 33.846 13.082 91616 87.440 28.019 13.280 0.681 31.884 13.261

MEAN 81.410 28.804 13.629 0.615 30.897 13.097 S.D. 7.0243 2.3345 1.1505 0.0629 2.1427 1.1461 S.E. 2.0278 0.6739 0.3321 0.0182 0.6186 0.3309 N 12 12 12 12 12 12**Page 893 of 1107**TABLE A46 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G]

MALE GROUP: 175 PPM

----------------------------------------------------------------------------------------------------------------------------------- TESTI EPIDIDY CAUDA E PITU EPIDIDY CAUDA E ANIMAL S, LT MIS, LT PID, LT ITARY MIS, RT PID, RT

----------------------------------------------------------------------------------------------------------------------------------- 91565 68.447 25.728 12.257 0.515 28.641 12.252 91568 80.402 31.156 14.678 0.704 31.156 12.513 91570 87.958 31.937 13.524 0.649 33.508 14.911 91572 78.947 28.708 13.029 0.579 30.144 13.388 91580 86.000 29.000 14.330 0.630 28.000 12.020 91584 86.139 32.673 13.649 0.683 30.693 12.540 91587 92.118 32.512 15.739 0.665 32.512 13.414 91597 91.623 30.890 13.969 0.592 34.555 14.372 91601 77.941 29.412 13.853 0.583 30.392 13.201 91607 77.880 28.571 13.313 0.608 32.719 13.779 91613 78.392 28.141 11.221 0.724 30.653 11.518 91614 83.756 34.518 16.650 0.650 36.041 15.746

MEAN 82.467 30.271 13.851 0.632 31.584 13.305 S.D. 6.7831 2.4427 1.4427 0.0595 2.3623 1.2467 S.E. 1.9581 0.7051 0.4165 0.0172 0.6819 0.3599 N 12 12 12 12 12 12**Page 894 of 1107**TABLE A46 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G]

MALE GROUP: 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- TESTI EPIDIDY CAUDA E PITU EPIDIDY CAUDA E ANIMAL S, LT MIS, LT PID, LT ITARY MIS, RT PID, RT

----------------------------------------------------------------------------------------------------------------------------------- 91554 77.157 31.980 15.127 0.660 28.934 11.497 91557 87.442 28.837 12.609 0.740 30.698 13.767 91558 81.443 28.351 14.284 0.552 31.959 13.670 91571 76.142 27.919 13.670 0.635 29.442 13.442 91575 71.101 25.688 9.651 0.560 27.064 11.413 91600 80.751 30.047 14.925 0.620 34.272 14.897 91603 89.637 34.197 14.668 0.637 35.233 13.223 91604 90.476 33.862 15.217 0.788 35.979 13.857 91605 93.000 30.000 15.095 0.635 30.500 12.530 91612 86.111 30.556 14.287 0.620 34.259 12.944 91618 71.429 26.728 12.226 0.724 29.032 12.410 91619 79.024 25.854 12.605 0.639 27.317 11.366

MEAN 81.976 29.501 13.697 0.651 31.224 12.918 S.D. 7.3653 2.8392 1.6613 0.0694 3.0796 1.1101 S.E. 2.1262 0.8196 0.4796 0.0200 0.8890 0.3204 N 12 12 12 12 12 12

POFBWv4.31 11/25/2013 R:01/17/2014**Page 895 of 1107**TABLE A47 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]

FEMALE GROUP: 0 PPM

----------------------------------------------------------------------------------------------------------------------------------- PITU ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS OVARIES ITARY

----------------------------------------------------------------------------------------------------------------------------------- 91629 308. 1.96 12.71 2.16 0.67 1.47 0.1023 0.0143 91630 324. 1.96 15.97 2.32 0.59 1.53 0.0903 0.0198 91633 361. 2.02 14.39 2.41 0.82 1.33 0.1462 0.0214 91637 320. 1.94 12.77 2.31 0.64 1.25 0.1021 0.0173 91639 361. 1.95 14.15 2.13 0.65 1.54 0.1524 0.0201 91644 313. 1.89 13.08 2.37 0.66 1.57 0.1213 0.0225 91645 342. 1.98 15.82 2.32 0.61 1.50 0.1106 0.0201 91648 359. 1.95 14.92 2.34 0.77 1.47 0.1255 0.0203 91653 347. 1.95 13.47 2.20 0.75 1.19 0.1329 0.0220 91660 368. 2.09 15.74 2.42 0.72 1.53 0.1325 0.0271 91670 332. 2.01 13.90 2.31 0.59 1.43 0.1371 0.0205 91672 374. 2.06 17.93 2.37 0.91 1.76 0.1561 0.0229

MEAN 342. 1.98 14.57 2.31 0.70 1.46 0.1258 0.0207 S.D. 22.6 0.056 1.569 0.094 0.099 0.152 0.02109 0.00310 S.E. 6.5 0.016 0.453 0.027 0.028 0.044 0.00609 0.00089 N 12 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT**Page 896 of 1107**TABLE A47 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]

FEMALE GROUP: 50 PPM

----------------------------------------------------------------------------------------------------------------------------------- PITU ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS OVARIES ITARY

----------------------------------------------------------------------------------------------------------------------------------- 91632 321. 1.87 12.83 2.39 0.59 1.45 0.1072 0.0188 91640 362. 2.02 15.05 2.55 1.09 1.89 0.1252 0.0206 91642 349. 1.88 14.48 2.53 0.80 1.51 0.0948 0.0212 91647 296. 1.80 12.87 2.04 0.58 1.39 0.0989 0.0189 91651 329. 1.91 14.86 2.37 0.61 1.69 0.0894 0.0168 91659 371. 2.10 16.38 2.43 0.82 1.51 0.1208 0.0205 91661 315. 1.92 13.20 2.35 0.61 1.54 0.1072 0.0160 91663 324. 1.94 12.37 2.13 0.64 1.40 0.1085 0.0183 91669 325. 2.09 13.48 2.11 0.84 1.49 0.1419 0.0171 91673 321. 2.00 14.97 2.51 0.70 1.65 0.1319 0.0200 91683 321. 1.89 13.75 2.19 0.74 1.43 0.1099 0.0194 91685 292. 2.04 11.44 2.02 0.57 1.45 0.1351 0.0198

MEAN 327. 1.96 13.81 2.30 0.72 1.53 0.1142 0.0190 S.D. 23.5 0.094 1.384 0.194 0.153 0.145 0.01667 0.00164 S.E. 6.8 0.027 0.399 0.056 0.044 0.042 0.00481 0.00047 N 12 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT**Page 897 of 1107**TABLE A47 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]

FEMALE GROUP: 100 PPM

----------------------------------------------------------------------------------------------------------------------------------- PITU ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS OVARIES ITARY

----------------------------------------------------------------------------------------------------------------------------------- 91620 351. 1.89 13.72 2.31 0.98 1.44 0.1291 0.0166 91628 289. 1.93 12.30 2.02 0.59 1.39 0.1142 0.0161 91631 351. 1.87 15.89 2.79 0.76 1.43 0.1094 0.0159 91636 289. 1.86 12.10 2.07 0.72 1.41 0.1071 0.0176 91649 305. 1.87 13.32 2.22 0.89 1.47 0.1284 0.0121 91650 355. 1.88 14.91 2.46 0.94 1.62 0.1214 0.0210 91656 330. 1.93 13.29 2.22 0.60 1.51 0.0969 0.0159 91671 346. 1.90 14.61 2.22 1.19 1.41 0.1100 0.0179 91675 359. 2.06 14.93 2.45 0.91 1.56 0.1321 0.0140 91677 309. 2.00 11.13 2.20 0.66 1.37 0.1184 0.0138 91679 338. 1.94 13.87 2.25 1.15 1.90 0.1544 0.0126 91684 286. 1.96 12.90 1.76 0.53 1.48 0.1091 0.0132

MEAN 326. 1.92 13.58 2.25 0.83 1.50 0.1192 0.0156 S.D. 28.3 0.060 1.366 0.254 0.218 0.146 0.01521 0.00257 S.E. 8.2 0.017 0.394 0.073 0.063 0.042 0.00439 0.00074 N 12 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT**Page 898 of 1107**TABLE A47 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]

FEMALE GROUP: 175 PPM

----------------------------------------------------------------------------------------------------------------------------------- PITU ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS OVARIES ITARY

----------------------------------------------------------------------------------------------------------------------------------- 91622 301. 1.96 14.01 2.10 0.96 1.68 0.1147 0.0162 91626 367. 2.14 15.70 2.26 0.77 1.54 0.1211 0.0247 91643 360. 2.07 15.14 2.32 1.13 1.60 0.1118 0.0199 91657 354. 1.89 14.64 2.70 0.77 1.64 0.1375 0.0174 91662 330. 1.92 14.66 2.39 0.76 1.53 0.1244 0.0147 91666 285. 1.88 11.95 2.03 0.79 1.42 0.0850 0.0105 91676 317. 1.97 13.90 2.42 0.80 1.46 0.0890 0.0174 91678 396. 2.08 16.10 2.38 0.90 1.61 0.1343 0.0221 91681 320. 2.00 13.84 2.26 0.69 1.49 0.1230 0.0170 91682 338. 1.97 14.44 2.42 1.10 1.46 0.1347 0.0146

MEAN 337. 1.99 14.44 2.33 0.87 1.54 0.1176 0.0175 S.D. 33.2 0.085 1.153 0.186 0.151 0.087 0.01819 0.00403 S.E. 10.5 0.027 0.365 0.059 0.048 0.027 0.00575 0.00127 N 10 10 10 10 10 10 10 10

FBW = FINAL BODY WEIGHT**Page 899 of 1107**TABLE A47 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]

FEMALE GROUP: 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- PITU ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS OVARIES ITARY

----------------------------------------------------------------------------------------------------------------------------------- 91624 321. 2.03 12.89 2.18 0.75 1.47 0.1124 0.0161 91625 293. 1.85 12.81 1.74 0.56 1.20 0.1289 0.0199 91627 303. 1.92 12.77 2.27 0.68 1.42 0.1083 0.0189 91634 331. 1.95 13.39 2.60 0.64 1.42 0.1248 0.0169 91635 338. 2.13 14.56 2.11 0.73 1.53 0.1147 0.0193 91638 319. 2.06 11.86 1.95 0.57 1.43 0.1067 0.0169 91652 355. 1.94 14.76 2.46 0.97 1.52 0.1185 0.0180 91655 317. 1.96 14.16 2.57 0.91 1.52 0.1034 0.0141 91658 325. 1.96 13.86 2.17 0.63 1.28 0.0901 0.0161 91667 348. 1.89 14.53 2.31 0.60 1.33 0.1316 0.0192 91668 342. 2.06 14.59 2.65 1.31 1.60 0.1886 0.0161 91680 325. 1.93 13.70 2.00 0.56 1.54 0.1366 0.0190

MEAN 326. 1.97 13.66 2.25 0.74 1.44 0.1221 0.0175 S.D. 17.9 0.081 0.922 0.282 0.223 0.118 0.02475 0.00177 S.E. 5.2 0.023 0.266 0.081 0.064 0.034 0.00715 0.00051 N 12 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT

POFBWv4.31 01/20/2014**Page 900 of 1107**TABLE A48 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]

FEMALE GROUP: 0 PPM

----------------------------------------------------------------------------------------------------------------------------------- PITU ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS OVARIES ITARY

----------------------------------------------------------------------------------------------------------------------------------- 91629 308. 0.636 4.127 0.701 0.218 0.477 0.033 0.005 91630 324. 0.605 4.929 0.716 0.182 0.472 0.028 0.006 91633 361. 0.560 3.986 0.668 0.227 0.368 0.040 0.006 91637 320. 0.606 3.991 0.722 0.200 0.391 0.032 0.005 91639 361. 0.540 3.920 0.590 0.180 0.427 0.042 0.006 91644 313. 0.604 4.179 0.757 0.211 0.502 0.039 0.007 91645 342. 0.579 4.626 0.678 0.178 0.439 0.032 0.006 91648 359. 0.543 4.156 0.652 0.214 0.409 0.035 0.006 91653 347. 0.562 3.882 0.634 0.216 0.343 0.038 0.006 91660 368. 0.568 4.277 0.658 0.196 0.416 0.036 0.007 91670 332. 0.605 4.187 0.696 0.178 0.431 0.041 0.006 91672 374. 0.551 4.794 0.634 0.243 0.471 0.042 0.006

MEAN 342. 0.580 4.254 0.675 0.204 0.429 0.037 0.006 S.D. 22.6 0.0307 0.3456 0.0460 0.0214 0.0471 0.0046 0.0006 S.E. 6.5 0.0089 0.0998 0.0133 0.0062 0.0136 0.0013 0.0002 N 12 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT**Page 901 of 1107**TABLE A48 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]

FEMALE GROUP: 50 PPM

----------------------------------------------------------------------------------------------------------------------------------- PITU ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS OVARIES ITARY

----------------------------------------------------------------------------------------------------------------------------------- 91632 321. 0.583 3.997 0.745 0.184 0.452 0.033 0.006 91640 362. 0.558 4.157 0.704 0.301 0.522 0.035 0.006 91642 349. 0.539 4.149 0.725 0.229 0.433 0.027 0.006 91647 296. 0.608 4.348 0.689 0.196 0.470 0.033 0.006 91651 329. 0.581 4.517 0.720 0.185 0.514 0.027 0.005 91659 371. 0.566 4.415 0.655 0.221 0.407 0.033 0.006 91661 315. 0.610 4.190 0.746 0.194 0.489 0.034 0.005 91663 324. 0.599 3.818 0.657 0.198 0.432 0.033 0.006 91669 325. 0.643 4.148 0.649 0.258 0.458 0.044 0.005 91673 321. 0.623 4.664 0.782 0.218 0.514 0.041 0.006 91683 321. 0.589 4.283 0.682 0.231 0.445 0.034 0.006 91685 292. 0.699 3.918 0.692 0.195 0.497 0.046 0.007

MEAN 327. 0.600 4.217 0.704 0.217 0.469 0.035 0.006 S.D. 23.5 0.0424 0.2451 0.0411 0.0345 0.0375 0.0059 0.0006 S.E. 6.8 0.0122 0.0708 0.0119 0.0100 0.0108 0.0017 0.0002 N 12 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT**Page 902 of 1107**TABLE A48 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]

FEMALE GROUP: 100 PPM

----------------------------------------------------------------------------------------------------------------------------------- PITU ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS OVARIES ITARY

----------------------------------------------------------------------------------------------------------------------------------- 91620 351. 0.538 3.909 0.658 0.279 0.410 0.037 0.005 91628 289. 0.668 4.256 0.699 0.204 0.481 0.040 0.006 91631 351. 0.533 4.527 0.795 0.217 0.407 0.031 0.005 91636 289. 0.644 4.187 0.716 0.249 0.488 0.037 0.006 91649 305. 0.613 4.367 0.728 0.292 0.482 0.042 0.004 91650 355. 0.530 4.200 0.693 0.265 0.456 0.034 0.006 91656 330. 0.585 4.027 0.673 0.182 0.458 0.029 0.005 91671 346. 0.549 4.223 0.642 0.344 0.408 0.032 0.005 91675 359. 0.574 4.159 0.682 0.253 0.435 0.037 0.004 91677 309. 0.647 3.602 0.712 0.214 0.443 0.038 0.004 91679 338. 0.574 4.104 0.666 0.340 0.562 0.046 0.004 91684 286. 0.685 4.510 0.615 0.185 0.517 0.038 0.005

MEAN 326. 0.595 4.173 0.690 0.252 0.462 0.037 0.005 S.D. 28.3 0.0550 0.2540 0.0463 0.0549 0.0470 0.0046 0.0008 S.E. 8.2 0.0159 0.0733 0.0134 0.0158 0.0136 0.0013 0.0002 N 12 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT**Page 903 of 1107**TABLE A48 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]

FEMALE GROUP: 175 PPM

----------------------------------------------------------------------------------------------------------------------------------- PITU ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS OVARIES ITARY

----------------------------------------------------------------------------------------------------------------------------------- 91622 301. 0.651 4.654 0.698 0.319 0.558 0.038 0.005 91626 367. 0.583 4.278 0.616 0.210 0.420 0.033 0.007 91643 360. 0.575 4.206 0.644 0.314 0.444 0.031 0.006 91657 354. 0.534 4.136 0.763 0.218 0.463 0.039 0.005 91662 330. 0.582 4.442 0.724 0.230 0.464 0.038 0.004 91666 285. 0.660 4.193 0.712 0.277 0.498 0.030 0.004 91676 317. 0.621 4.385 0.763 0.252 0.461 0.028 0.005 91678 396. 0.525 4.066 0.601 0.227 0.407 0.034 0.006 91681 320. 0.625 4.325 0.706 0.216 0.466 0.038 0.005 91682 338. 0.583 4.272 0.716 0.325 0.432 0.040 0.004

MEAN 337. 0.594 4.296 0.694 0.259 0.461 0.035 0.005 S.D. 33.2 0.0452 0.1690 0.0564 0.0462 0.0430 0.0042 0.0010 S.E. 10.5 0.0143 0.0535 0.0178 0.0146 0.0136 0.0013 0.0003 N 10 10 10 10 10 10 10 10

FBW = FINAL BODY WEIGHT**Page 904 of 1107**TABLE A48 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]

FEMALE GROUP: 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- PITU ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS OVARIES ITARY

----------------------------------------------------------------------------------------------------------------------------------- 91624 321. 0.632 4.016 0.679 0.234 0.458 0.035 0.005 91625 293. 0.631 4.372 0.594 0.191 0.410 0.044 0.007 91627 303. 0.634 4.215 0.749 0.224 0.469 0.036 0.006 91634 331. 0.589 4.045 0.785 0.193 0.429 0.038 0.005 91635 338. 0.630 4.308 0.624 0.216 0.453 0.034 0.006 91638 319. 0.646 3.718 0.611 0.179 0.448 0.033 0.005 91652 355. 0.546 4.158 0.693 0.273 0.428 0.033 0.005 91655 317. 0.618 4.467 0.811 0.287 0.479 0.033 0.004 91658 325. 0.603 4.265 0.668 0.194 0.394 0.028 0.005 91667 348. 0.543 4.175 0.664 0.172 0.382 0.038 0.006 91668 342. 0.602 4.266 0.775 0.383 0.468 0.055 0.005 91680 325. 0.594 4.215 0.615 0.172 0.474 0.042 0.006

MEAN 326. 0.606 4.185 0.689 0.227 0.441 0.037 0.005 S.D. 17.9 0.0335 0.1934 0.0745 0.0619 0.0323 0.0071 0.0008 S.E. 5.2 0.0097 0.0558 0.0215 0.0179 0.0093 0.0020 0.0002 N 12 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT

POFBWv4.31 01/20/2014**Page 905 of 1107**TABLE A49 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G]

FEMALE GROUP: 0 PPM

----------------------------------------------------------------------------------------------------------------------------------- BRAIN WT PITU ANIMAL FBW(G) (GRAMS) LIVER KIDNEYS SPLEEN LUNGS OVARIES ITARY

----------------------------------------------------------------------------------------------------------------------------------- 91629 308. 1.96 648.469 110.204 34.184 75.000 5.219 0.730 91630 324. 1.96 814.796 118.367 30.102 78.061 4.607 1.010 91633 361. 2.02 712.376 119.307 40.594 65.842 7.238 1.059 91637 320. 1.94 658.247 119.072 32.990 64.433 5.263 0.892 91639 361. 1.95 725.641 109.231 33.333 78.974 7.815 1.031 91644 313. 1.89 692.063 125.397 34.921 83.069 6.418 1.190 91645 342. 1.98 798.990 117.172 30.808 75.758 5.586 1.015 91648 359. 1.95 765.128 120.000 39.487 75.385 6.436 1.041 91653 347. 1.95 690.769 112.821 38.462 61.026 6.815 1.128 91660 368. 2.09 753.110 115.789 34.450 73.206 6.340 1.297 91670 332. 2.01 691.542 114.925 29.353 71.144 6.821 1.020 91672 374. 2.06 870.388 115.049 44.175 85.437 7.578 1.112

MEAN 342. 1.98 735.127 116.444 35.238 73.944 6.345 1.044 S.D. 22.6 0.056 67.2134 4.4814 4.5542 7.3575 0.9988 0.1420 S.E. 6.5 0.016 19.4028 1.2937 1.3147 2.1239 0.2883 0.0410 N 12 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT**Page 906 of 1107**TABLE A49 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G]

FEMALE GROUP: 50 PPM

----------------------------------------------------------------------------------------------------------------------------------- BRAIN WT PITU ANIMAL FBW(G) (GRAMS) LIVER KIDNEYS SPLEEN LUNGS OVARIES ITARY

----------------------------------------------------------------------------------------------------------------------------------- 91632 321. 1.87 686.096 127.807 31.551 77.540 5.733 1.005 91640 362. 2.02 745.050 126.238 53.960 93.564 6.198 1.020 91642 349. 1.88 770.213 134.574 42.553 80.319 5.043 1.128 91647 296. 1.80 715.000 113.333 32.222 77.222 5.494 1.050 91651 329. 1.91 778.010 124.084 31.937 88.482 4.681 0.880 91659 371. 2.10 780.000 115.714 39.048 71.905 5.752 0.976 91661 315. 1.92 687.500 122.396 31.771 80.208 5.583 0.833 91663 324. 1.94 637.629 109.794 32.990 72.165 5.593 0.943 91669 325. 2.09 644.976 100.957 40.191 71.292 6.789 0.818 91673 321. 2.00 748.500 125.500 35.000 82.500 6.595 1.000 91683 321. 1.89 727.513 115.873 39.153 75.661 5.815 1.026 91685 292. 2.04 560.784 99.020 27.941 71.078 6.623 0.971

MEAN 327. 1.96 706.773 117.941 36.526 78.495 5.825 0.971 S.D. 23.5 0.094 66.6586 10.8749 7.0224 7.0716 0.6364 0.0904 S.E. 6.8 0.027 19.2427 3.1393 2.0272 2.0414 0.1837 0.0261 N 12 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT**Page 907 of 1107**TABLE A49 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G]

FEMALE GROUP: 100 PPM

----------------------------------------------------------------------------------------------------------------------------------- BRAIN WT PITU ANIMAL FBW(G) (GRAMS) LIVER KIDNEYS SPLEEN LUNGS OVARIES ITARY

----------------------------------------------------------------------------------------------------------------------------------- 91620 351. 1.89 725.926 122.222 51.852 76.190 6.831 0.878 91628 289. 1.93 637.306 104.663 30.570 72.021 5.917 0.834 91631 351. 1.87 849.733 149.198 40.642 76.471 5.850 0.850 91636 289. 1.86 650.538 111.290 38.710 75.806 5.758 0.946 91649 305. 1.87 712.299 118.717 47.594 78.610 6.866 0.647 91650 355. 1.88 793.085 130.851 50.000 86.170 6.457 1.117 91656 330. 1.93 688.601 115.026 31.088 78.238 5.021 0.824 91671 346. 1.90 768.947 116.842 62.632 74.211 5.789 0.942 91675 359. 2.06 724.757 118.932 44.175 75.728 6.413 0.680 91677 309. 2.00 556.500 110.000 33.000 68.500 5.920 0.690 91679 338. 1.94 714.948 115.979 59.278 97.938 7.959 0.649 91684 286. 1.96 658.163 89.796 27.041 75.510 5.566 0.673

MEAN 326. 1.92 706.734 116.960 43.048 77.949 6.196 0.811 S.D. 28.3 0.060 77.3444 14.2743 11.5808 7.5488 0.7677 0.1476 S.E. 8.2 0.017 22.3274 4.1206 3.3431 2.1791 0.2216 0.0426 N 12 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT**Page 908 of 1107**TABLE A49 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G]

FEMALE GROUP: 175 PPM

----------------------------------------------------------------------------------------------------------------------------------- BRAIN WT PITU ANIMAL FBW(G) (GRAMS) LIVER KIDNEYS SPLEEN LUNGS OVARIES ITARY

----------------------------------------------------------------------------------------------------------------------------------- 91622 301. 1.96 714.796 107.143 48.980 85.714 5.852 0.827 91626 367. 2.14 733.645 105.607 35.981 71.963 5.659 1.154 91643 360. 2.07 731.401 112.077 54.589 77.295 5.401 0.961 91657 354. 1.89 774.603 142.857 40.741 86.772 7.275 0.921 91662 330. 1.92 763.542 124.479 39.583 79.688 6.479 0.766 91666 285. 1.88 635.638 107.979 42.021 75.532 4.521 0.559 91676 317. 1.97 705.584 122.843 40.609 74.112 4.518 0.883 91678 396. 2.08 774.039 114.423 43.269 77.404 6.457 1.063 91681 320. 2.00 692.000 113.000 34.500 74.500 6.150 0.850 91682 338. 1.97 732.995 122.843 55.838 74.112 6.838 0.741

MEAN 337. 1.99 725.824 117.325 43.611 77.709 5.915 0.873 S.D. 33.2 0.085 42.2679 11.2889 7.2738 4.9928 0.9187 0.1684 S.E. 10.5 0.027 13.3663 3.5699 2.3002 1.5789 0.2905 0.0533 N 10 10 10 10 10 10 10 10

FBW = FINAL BODY WEIGHT**Page 909 of 1107**TABLE A49 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G]

FEMALE GROUP: 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- BRAIN WT PITU ANIMAL FBW(G) (GRAMS) LIVER KIDNEYS SPLEEN LUNGS OVARIES ITARY

----------------------------------------------------------------------------------------------------------------------------------- 91624 321. 2.03 634.975 107.389 36.946 72.414 5.537 0.793 91625 293. 1.85 692.432 94.054 30.270 64.865 6.968 1.076 91627 303. 1.92 665.104 118.229 35.417 73.958 5.641 0.984 91634 331. 1.95 686.667 133.333 32.821 72.821 6.400 0.867 91635 338. 2.13 683.568 99.061 34.272 71.831 5.385 0.906 91638 319. 2.06 575.728 94.660 27.670 69.417 5.180 0.820 91652 355. 1.94 760.825 126.804 50.000 78.351 6.108 0.928 91655 317. 1.96 722.449 131.122 46.429 77.551 5.276 0.719 91658 325. 1.96 707.143 110.714 32.143 65.306 4.597 0.821 91667 348. 1.89 768.783 122.222 31.746 70.370 6.963 1.016 91668 342. 2.06 708.253 128.641 63.592 77.670 9.155 0.782 91680 325. 1.93 709.845 103.627 29.016 79.793 7.078 0.984

MEAN 326. 1.97 692.981 114.155 37.527 72.862 6.191 0.891 S.D. 17.9 0.081 52.1833 14.4209 10.6020 4.9068 1.2287 0.1088 S.E. 5.2 0.023 15.0640 4.1630 3.0605 1.4165 0.3547 0.0314 N 12 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT

POFBWv4.31 01/20/2014**Page 910 of 1107**TABLE A50 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OVARIAN PRIMORDIAL FOLLICLE COUNTS

0 PPM PRIMORDIAL ANIMAL FOLLICLES

----------------------------------------------------------------------------------------------------------------------------------- 91629 85 91630 44 91633 42 91637 70 91639 58 91644 45 91645 48 91648 74 91653 38 91660 26 91670 58 91672 4

----------------------------------------------------------------------------------------------------------------------------------- MEAN 49.3 S.D. 21.93 S.E. 6.33 N 12**Page 911 of 1107**TABLE A50 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OVARIAN PRIMORDIAL FOLLICLE COUNTS

175 PPM PRIMORDIAL ANIMAL FOLLICLES

----------------------------------------------------------------------------------------------------------------------------------- 91623 36 91622 23 91626 62 91643 60 91654 54 91657 34 91662 26 91666 66 91676 19 91678 28 91681 62 91682 47

----------------------------------------------------------------------------------------------------------------------------------- MEAN 43.1 S.D. 17.31 S.E. 5.00 N 12**Page 912 of 1107**TABLE A50 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OVARIAN PRIMORDIAL FOLLICLE COUNTS

10000 PPM PRIMORDIAL ANIMAL FOLLICLES

----------------------------------------------------------------------------------------------------------------------------------- 91624 54 91625 63 91627 75 91634 42 91635 8 91638 51 91652 214 91655 57 91658 111 91667 59 91668 44 91680 38

----------------------------------------------------------------------------------------------------------------------------------- MEAN 68.0 S.D. 51.94 S.E. 14.99 N 12 MANUALv1.0 01/21/2014 R:01/24/2014**Page 913 of 1107**TABLE A51 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL LITTER VIABILITY

GROUP: 0 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAM # PND 0 1 2 3 4

----------------------------------------------------------------------------------------------------------------------------------- 91629 ALIVE 16 16 15 15 0 DEAD 1 SCHED. EUTH. 15

91630 ALIVE 12 12 12 12 0 DEAD 2 SCHED. EUTH. 12

91633 ALIVE 15 15 15 15 0 SCHED. EUTH. 15

91637 ALIVE 13 13 13 12 0 DEAD 1 SCHED. EUTH. 12

91639 ALIVE 10 9 9 9 0 DEAD 1 SCHED. EUTH. 9

91644 ALIVE 17 17 17 17 0 SCHED. EUTH. 16 MISSING 1

91645 ALIVE 15 15 15 15 0 DEAD 1 SCHED. EUTH. 15

91648 ALIVE 13 13 13 13 0 DEAD 1 SCHED. EUTH. 13

91653 ALIVE 15 15 15 15 0 SCHED. EUTH. 15

----------------------------------------------------------------------------------------------------------------------------------- DEAD= FOUND DEAD, SCHED. EUTH.= SCHEDULED EUTHANASIA**Page 914 of 1107**TABLE A51 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL LITTER VIABILITY

GROUP: 0 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAM # PND 0 1 2 3 4

----------------------------------------------------------------------------------------------------------------------------------- 91660 ALIVE 13 13 13 13 0 DEAD 1 SCHED. EUTH. 13

91670 ALIVE 14 14 14 14 0 SCHED. EUTH. 14

91672 ALIVE 13 13 12 12 0 DEAD 1 1 1 SCHED. EUTH. 11

----------------------------------------------------------------------------------------------------------------------------------- DEAD= FOUND DEAD, SCHED. EUTH.= SCHEDULED EUTHANASIA**Page 915 of 1107**TABLE A51 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL LITTER VIABILITY

GROUP: 50 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAM # PND 0 1 2 3 4

----------------------------------------------------------------------------------------------------------------------------------- 91632 ALIVE 15 15 14 14 0 DEAD 1 SCHED. EUTH. 14

91640 ALIVE 10 10 10 10 0 DEAD 2 SCHED. EUTH. 10

91642 ALIVE 15 15 15 15 0 SCHED. EUTH. 15

91647 ALIVE 12 11 11 11 0 DEAD 1 SCHED. EUTH. 11 MISSING 1

91651 ALIVE 12 12 12 12 0 SCHED. EUTH. 12

91659 ALIVE 13 12 12 12 0 DEAD 1 SCHED. EUTH. 12

91661 ALIVE 17 17 17 17 0 SCHED. EUTH. 17

91663 ALIVE 15 14 14 14 0 DEAD 1 1 SCHED. EUTH. 13

91669 ALIVE 16 16 16 15 0 DEAD 1 3 SCHED. EUTH. 12

91673 ALIVE 16 16 16 16 0 SCHED. EUTH. 16

----------------------------------------------------------------------------------------------------------------------------------- DEAD= FOUND DEAD, SCHED. EUTH.= SCHEDULED EUTHANASIA**Page 916 of 1107**TABLE A51 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL LITTER VIABILITY

GROUP: 50 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAM # PND 0 1 2 3 4

----------------------------------------------------------------------------------------------------------------------------------- 91683 ALIVE 12 12 12 12 0 SCHED. EUTH. 12

91685 ALIVE 10 10 9 9 0 SCHED. EUTH. 9 MISSING 1

----------------------------------------------------------------------------------------------------------------------------------- SCHED. EUTH.= SCHEDULED EUTHANASIA**Page 917 of 1107**TABLE A51 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL LITTER VIABILITY

GROUP: 100 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAM # PND 0 1 2 3 4

----------------------------------------------------------------------------------------------------------------------------------- 91620 ALIVE 13 13 13 13 0 DEAD 1 SCHED. EUTH. 13

91628 ALIVE 14 14 14 14 0 DEAD 1 SCHED. EUTH. 14

91631 ALIVE 15 15 14 13 0 DEAD 1 1 SCHED. EUTH. 13

91636 ALIVE 13 13 13 13 0 SCHED. EUTH. 13

91649 ALIVE 16 16 16 16 0 SCHED. EUTH. 16

91650 ALIVE 13 13 13 13 0 DEAD 1 SCHED. EUTH. 13

91656 ALIVE 14 12 12 11 0 DEAD 1 SCHED. EUTH. 11 MISSING 2 1

91671 ALIVE 13 11 11 11 0 DEAD 2 1 SCHED. EUTH. 11 MISSING 1

91675 ALIVE 14 13 12 12 0 DEAD 1 1 SCHED. EUTH. 11 MISSING 1

----------------------------------------------------------------------------------------------------------------------------------- DEAD= FOUND DEAD, SCHED. EUTH.= SCHEDULED EUTHANASIA**Page 918 of 1107**TABLE A51 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL LITTER VIABILITY

GROUP: 100 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAM # PND 0 1 2 3 4

----------------------------------------------------------------------------------------------------------------------------------- 91677 ALIVE 5 5 5 3 0 DEAD 1 SCHED. EUTH. 3 MISSING 1

91679 ALIVE 10 9 7 7 0 DEAD 2 1 1 SCHED. EUTH. 7 MISSING 1

91684 ALIVE 16 16 16 16 0 SCHED. EUTH. 16

----------------------------------------------------------------------------------------------------------------------------------- DEAD= FOUND DEAD, SCHED. EUTH.= SCHEDULED EUTHANASIA**Page 919 of 1107**TABLE A51 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL LITTER VIABILITY

GROUP: 175 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAM # PND 0 1 2 3 4

----------------------------------------------------------------------------------------------------------------------------------- 91622 ALIVE 14 11 9 8 0 DEAD 3 2 1 SCHED. EUTH. 8

91626 ALIVE 14 13 13 13 0 DEAD 1 SCHED. EUTH. 13

91643 ALIVE 12 11 11 11 0 DEAD 1 SCHED. EUTH. 11

91654 ALIVE 16 14 0 TOTAL LITTER LOSS DEAD 2 2 8 MISSING 6

91657 ALIVE 13 13 8 8 0 DEAD 5 SCHED. EUTH. 8

91662 ALIVE 9 9 8 7 0 DEAD 2 SCHED. EUTH. 7 MISSING 1 1

91666 ALIVE 11 10 10 10 0 DEAD 1 SCHED. EUTH. 10

91676 ALIVE 11 10 10 10 0 SCHED. EUTH. 10 MISSING 1

91678 ALIVE 14 14 14 14 0 DEAD 1 SCHED. EUTH. 13

----------------------------------------------------------------------------------------------------------------------------------- DEAD= FOUND DEAD, SCHED. EUTH.= SCHEDULED EUTHANASIA**Page 920 of 1107**TABLE A51 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL LITTER VIABILITY

GROUP: 175 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAM # PND 0 1 2 3 4

----------------------------------------------------------------------------------------------------------------------------------- 91681 ALIVE 13 11 10 10 0 DEAD 2 1 SCHED. EUTH. 10 MISSING 1 1

91682 ALIVE 12 11 7 5 0 DEAD 1 SCHED. EUTH. 5 MISSING 1 4 2

----------------------------------------------------------------------------------------------------------------------------------- DEAD= FOUND DEAD, SCHED. EUTH.= SCHEDULED EUTHANASIA**Page 921 of 1107**TABLE A51 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL LITTER VIABILITY

GROUP: 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAM # PND 0 1 2 3 4

----------------------------------------------------------------------------------------------------------------------------------- 91624 ALIVE 13 13 13 13 0 SCHED. EUTH. 13

91625 ALIVE 14 14 14 14 0 SCHED. EUTH. 14

91627 ALIVE 13 13 13 13 0 SCHED. EUTH. 13

91634 ALIVE 13 13 13 13 0 SCHED. EUTH. 13

91635 ALIVE 12 12 12 12 0 DEAD 1 SCHED. EUTH. 12

91638 ALIVE 16 16 16 16 0 SCHED. EUTH. 16

91652 ALIVE 11 11 11 11 0 DEAD; CANN. 1 DEAD 1 SCHED. EUTH. 11

91655 ALIVE 13 12 11 11 0 DEAD 1 1 SCHED. EUTH. 11

91658 ALIVE 13 13 13 13 0 SCHED. EUTH. 13

91667 ALIVE 16 16 16 16 0 SCHED. EUTH. 16

----------------------------------------------------------------------------------------------------------------------------------- DEAD; CANN.= FOUND DEAD; PARTIALLY CANNIBALIZED, DEAD= FOUND DEAD, SCHED. EUTH.= SCHEDULED EUTHANASIA**Page 922 of 1107**TABLE A51 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL LITTER VIABILITY

GROUP: 10000 PPM

----------------------------------------------------------------------------------------------------------------------------------- DAM # PND 0 1 2 3 4

----------------------------------------------------------------------------------------------------------------------------------- 91668 ALIVE 13 13 13 13 0 DEAD; CANN. 1 DEAD 1 SCHED. EUTH. 13

91680 ALIVE 15 15 15 15 0 SCHED. EUTH. 15

----------------------------------------------------------------------------------------------------------------------------------- DEAD; CANN.= FOUND DEAD; PARTIALLY CANNIBALIZED, DEAD= FOUND DEAD, SCHED. EUTH.= SCHEDULED EUTHANASIA PPVIAv4.04 02/18/2014**Page 923 of 1107**TABLE A52 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP VIABILITY

-------------------------------------------------------- LITTERS FROM GROUP 1: 0 PPM

-------------------------------------------------------- DAY OF DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

----------------------------------------------------------------------------------------------------------------------------------- 91629 21-NOV-13 m4 m4 m4 m4 m4 m4 e2 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M M M M M M M M M M M F F F F

91630 22-NOV-13 e0 e0 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M M M M M M M F F F F F F

91633 19-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M M M M M M F F F F F F F F

91637 18-NOV-13 m4 m4 m4 m4 e3 m4 m4 m4 m4 m4 m4 m4 m4
M M M M M F F F F F F F F

91639 21-NOV-13 e1 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M M M M M M M F F

91644 19-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 s4
M M M M M M M M M M F F F F F F F

91645 22-NOV-13 m4 m4 m4 m4 m4 m4 m4 e0 m4 m4 m4 m4 m4 m4 m4 m4
M M M M M M M M M F F F F F F F

91648 19-NOV-13 e0 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M M M M M M M M F F F F F

91653 21-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M M M M M F F F F F F F F F

----------------------------------------------------------------------------------------------------------------------------------- A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4, M = MALE, F = FEMALE, U = UNDETERMINED e = FOUND DEAD, m = SCHEDULED EUTHANASIA, s = MISSING**Page 924 of 1107**TABLE A52 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP VIABILITY

-------------------------------------------------------- LITTERS FROM GROUP 1: 0 PPM

-------------------------------------------------------- DAY OF DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

----------------------------------------------------------------------------------------------------------------------------------- 91660 21-NOV-13 e0 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M M M M M M M M F F F F F

91670 22-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M M M M M M M F F F F F F

91672 22-NOV-13 e0 m4 m4 m4 m4 m4 e4 m4 m4 m4 e2 m4 m4 m4
F M M M M M M M F F F F F F

----------------------------------------------------------------------------------------------------------------------------------- A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4, M = MALE, F = FEMALE, U = UNDETERMINED e = FOUND DEAD, m = SCHEDULED EUTHANASIA**Page 925 of 1107**TABLE A52 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP VIABILITY

-------------------------------------------------------- LITTERS FROM GROUP 2: 50 PPM

-------------------------------------------------------- DAY OF DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

----------------------------------------------------------------------------------------------------------------------------------- 91632 23-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 e2
M M M M F F F F F F F F F F F

91640 23-NOV-13 e0 e0 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M F M M M F F F F F F

91642 20-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M M M F F F F F F F F F F M

91647 22-NOV-13 e0 s1 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
F M M M M M M M F F F F F

91651 21-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M M M M M M F F F F F

91659 20-NOV-13 e1 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M M M M M M F F F F F F

91661 19-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M M M M M M M M M M F F F F F F

91663 21-NOV-13 m4 e1 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 e4 m4
M M M M M M M F F F F F F F F

91669 19-NOV-13 m4 m4 m4 m4 e4 m4 m4 m4 m4 m4 e4 m4 m4 m4 e4 e3
M M M M M M M M M F F F F F F F

----------------------------------------------------------------------------------------------------------------------------------- A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4, M = MALE, F = FEMALE, U = UNDETERMINED e = FOUND DEAD, m = SCHEDULED EUTHANASIA, s = MISSING**Page 926 of 1107**TABLE A52 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP VIABILITY

-------------------------------------------------------- LITTERS FROM GROUP 2: 50 PPM

-------------------------------------------------------- DAY OF DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

----------------------------------------------------------------------------------------------------------------------------------- 91673 22-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M M M M M F F F F F F F F F F

91683 23-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M M M M M F F F F F F

91685 19-NOV-13 m4 m4 m4 m4 m4 m4 m4 s2 m4 m4
M M M M M F F F F F

----------------------------------------------------------------------------------------------------------------------------------- A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4, M = MALE, F = FEMALE, U = UNDETERMINED m = SCHEDULED EUTHANASIA, s = MISSING**Page 927 of 1107**TABLE A52 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP VIABILITY

-------------------------------------------------------- LITTERS FROM GROUP 3: 100 PPM

-------------------------------------------------------- DAY OF DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

----------------------------------------------------------------------------------------------------------------------------------- 91620 22-NOV-13 e0 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M M M M M M M M F F F F F

91628 20-NOV-13 e0 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
M F M M M M M M M F F F F F F

91631 20-NOV-13 e3 m4 m4 m4 m4 m4 m4 e2 m4 m4 m4 m4 m4 m4 m4
M M M M M M M M M F F F F F F

91636 21-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M M M F F F F F F F F F

91649 19-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M M M M M F F F F F F F F F F

91650 19-NOV-13 e0 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M M M M M M M F F F F F F

91656 24-NOV-13 e0 s1 m4 m4 s1 m4 m4 m4 m4 m4 m4 m4 m4 s3 m4
F M M M M M M F F F F F F F F

91671 24-NOV-13 e0 e0 m4 m4 m4 m4 s1 m4 m4 m4 e1 m4 m4 m4 m4
M F M M M M M M M F F F F F F

91675 20-NOV-13 m4 m4 m4 e1 m4 m4 m4 m4 m4 m4 e4 m4 m4 s2
M M M M M F F F F F F F F F

----------------------------------------------------------------------------------------------------------------------------------- A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4, M = MALE, F = FEMALE, U = UNDETERMINED e = FOUND DEAD, m = SCHEDULED EUTHANASIA, s = MISSING**Page 928 of 1107**TABLE A52 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP VIABILITY

-------------------------------------------------------- LITTERS FROM GROUP 3: 100 PPM

-------------------------------------------------------- DAY OF DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

----------------------------------------------------------------------------------------------------------------------------------- 91677 21-NOV-13 e3 m4 m4 s3 m4
M M F F F

91679 19-NOV-13 e0 e0 m4 m4 m4 s2 m4 m4 m4 e2 e1 m4
M F M M M M M M F F F F

91684 20-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M M M M M M M M F F F F F F F

----------------------------------------------------------------------------------------------------------------------------------- A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4, M = MALE, F = FEMALE, U = UNDETERMINED e = FOUND DEAD, m = SCHEDULED EUTHANASIA, s = MISSING**Page 929 of 1107**TABLE A52 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP VIABILITY

-------------------------------------------------------- LITTERS FROM GROUP 4: 175 PPM

-------------------------------------------------------- DAY OF DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

----------------------------------------------------------------------------------------------------------------------------------- 91622 19-NOV-13 e1 e1 e1 m4 m4 m4 m4 e2 m4 m4 m4 m4 e2 e3
M M F M M M M M M M F F F F

91626 22-NOV-13 e1 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
F M M M M M M F F F F F F F

91643 25-NOV-13 e1 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M M M M M M M M F F F

91654 25-NOV-13 e0 e0 e1 e2 e2 s2 e2 e2 e2 e1 s2 e2 s2 e2 s2 s2 e2 s2
F M M M M M M M M M M M M F F F F F

91657 30-NOV-13 e2 e2 e2 m4 m4 m4 e2 e2 m4 m4 m4 m4 m4
F M M M M M M F F F F F F

91662 22-NOV-13 e0 e0 m4 m4 m4 m4 s2 s3 m4 m4 m4
M F M M M M F F F F F

91666 20-NOV-13 e1 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
F M M M M M M M F F F

91676 21-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 s1 m4
M M M M M F F F F F F

91678 20-NOV-13 m4 m4 m4 m4 e4 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M M M F F F F F F F F F F

----------------------------------------------------------------------------------------------------------------------------------- A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4, M = MALE, F = FEMALE, U = UNDETERMINED e = FOUND DEAD, m = SCHEDULED EUTHANASIA, s = MISSING**Page 930 of 1107**TABLE A52 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP VIABILITY

-------------------------------------------------------- LITTERS FROM GROUP 4: 175 PPM

-------------------------------------------------------- DAY OF DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

----------------------------------------------------------------------------------------------------------------------------------- 91681 29-NOV-13 e0 e0 s1 m4 m4 m4 s2 e1 m4 m4 m4 m4 m4 m4 m4
F F M M M M M M M M F F F F F

91682 22-NOV-13 e0 s3 s1 m4 s2 m4 s2 m4 s3 s2 m4 m4 s2
F F M M M M M M M M M F F

----------------------------------------------------------------------------------------------------------------------------------- A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4, M = MALE, F = FEMALE, U = UNDETERMINED e = FOUND DEAD, m = SCHEDULED EUTHANASIA, s = MISSING**Page 931 of 1107**TABLE A52 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP VIABILITY

-------------------------------------------------------- LITTERS FROM GROUP 5: 10000 PPM

-------------------------------------------------------- DAY OF DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

----------------------------------------------------------------------------------------------------------------------------------- 91624 21-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M M M M M M M F F F F F

91625 22-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M M M M F F F F F F F F F

91627 19-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M M M M M M M F F F F F

91634 22-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M M M M M F F F F F F F

91635 19-NOV-13 e0 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M M M M M M F F F F F F

91638 21-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M M M M M M M M F F F F F F F

91652 19-NOV-13 e0 a0 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 M U M M M M M M M M F F F

91655 19-NOV-13 m4 m4 m4 m4 m4 m4 m4 e2 m4 m4 m4 m4 e1
M M M M F F F F F F F F F

91658 20-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M M M M M M M F F F F F

----------------------------------------------------------------------------------------------------------------------------------- A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4, M = MALE, F = FEMALE, U = UNDETERMINED a = FOUND DEAD; PARTIALLY CANNIBALIZED, e = FOUND DEAD, m = SCHEDULED EUTHANASIA**Page 932 of 1107**TABLE A52 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP VIABILITY

-------------------------------------------------------- LITTERS FROM GROUP 5: 10000 PPM

-------------------------------------------------------- DAY OF DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

----------------------------------------------------------------------------------------------------------------------------------- 91667 20-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M M M M F F F F F F F F F F F

91668 20-NOV-13 a0 e0 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 U M M M M M M M M M M F F F F

91680 19-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4
M M M M M M M F F F F F F F F

----------------------------------------------------------------------------------------------------------------------------------- A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4, M = MALE, F = FEMALE, U = UNDETERMINED a = FOUND DEAD; PARTIALLY CANNIBALIZED, e = FOUND DEAD, m = SCHEDULED EUTHANASIA PLITRv4.05 02/18/2014**Page 933 of 1107**TABLE A53 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL POSTNATAL SURVIVAL (% PER LITTER)

-------------------------------------------- LITTERS FROM GROUP 1: 0 PPM

-------------------------------------------- ANIMAL B 0- 1 1- 4 B- 4

----------------------------------------------------------------------------------------------------------------------------------- 91629 100.0 100.0 93.8 93.8 91630 85.7 100.0 100.0 85.7 91633 100.0 100.0 100.0 100.0 91637 100.0 100.0 92.3 92.3 91639 100.0 90.0 100.0 90.0 91644 100.0 100.0 94.1 94.1 91645 93.8 100.0 100.0 93.8 91648 92.9 100.0 100.0 92.9 91653 100.0 100.0 100.0 100.0 91660 92.9 100.0 100.0 92.9 91670 100.0 100.0 100.0 100.0 91672 92.9 100.0 84.6 78.6

MEAN 96.5 99.2 97.1 92.8 S.D. 4.76 2.89 4.92 6.18 S.E. 1.37 0.83 1.42 1.78 N 12 12 12 12

B= BIRTH**Page 934 of 1107**TABLE A53 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL POSTNATAL SURVIVAL (% PER LITTER)

-------------------------------------------- LITTERS FROM GROUP 2: 50 PPM

-------------------------------------------- ANIMAL B 0- 1 1- 4 B- 4

----------------------------------------------------------------------------------------------------------------------------------- 91632 100.0 100.0 93.3 93.3 91640 83.3 100.0 100.0 83.3 91642 100.0 100.0 100.0 100.0 91647 92.3 91.7 100.0 84.6 91651 100.0 100.0 100.0 100.0 91659 100.0 92.3 100.0 92.3 91661 100.0 100.0 100.0 100.0 91663 100.0 93.3 92.9 86.7 91669 100.0 100.0 75.0 75.0 91673 100.0 100.0 100.0 100.0 91683 100.0 100.0 100.0 100.0 91685 100.0 100.0 90.0 90.0

MEAN 98.0 98.1 95.9 92.1 S.D. 5.11 3.44 7.52 8.38 S.E. 1.48 0.99 2.17 2.42 N 12 12 12 12

B= BIRTH**Page 935 of 1107**TABLE A53 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL POSTNATAL SURVIVAL (% PER LITTER)

-------------------------------------------- LITTERS FROM GROUP 3: 100 PPM

-------------------------------------------- ANIMAL B 0- 1 1- 4 B- 4

----------------------------------------------------------------------------------------------------------------------------------- 91620 92.9 100.0 100.0 92.9 91628 93.3 100.0 100.0 93.3 91631 100.0 100.0 86.7 86.7 91636 100.0 100.0 100.0 100.0 91649 100.0 100.0 100.0 100.0 91650 92.9 100.0 100.0 92.9 91656 93.3 85.7 91.7 73.3 91671 86.7 84.6 100.0 73.3 91675 100.0 92.9 84.6 78.6 91677 100.0 100.0 60.0 60.0 91679 83.3 90.0 77.8 58.3 91684 100.0 100.0 100.0 100.0

MEAN 95.2 96.1 91.7 84.1 S.D. 5.80 6.10 12.64 15.11 S.E. 1.67 1.76 3.65 4.36 N 12 12 12 12

B= BIRTH**Page 936 of 1107**TABLE A53 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL POSTNATAL SURVIVAL (% PER LITTER)

-------------------------------------------- LITTERS FROM GROUP 4: 175 PPM

-------------------------------------------- ANIMAL B 0- 1 1- 4 B- 4

----------------------------------------------------------------------------------------------------------------------------------- 91622 100.0 78.6 72.7 57.1 91626 100.0 92.9 100.0 92.9 91643 100.0 91.7 100.0 91.7 91654 88.9 87.5 0.0 0.0 91657 100.0 100.0 61.5 61.5 91662 81.8 100.0 77.8 63.6 91666 100.0 90.9 100.0 90.9 91676 100.0 90.9 100.0 90.9 91678 100.0 100.0 92.9 92.9 91681 86.7 84.6 90.9 66.7 91682 92.3 91.7 45.5 38.5

MEAN 95.4 91.7 76.5 67.9 S.D. 6.79 6.70 31.21 29.19 S.E. 2.05 2.02 9.41 8.80 N 11 11 11 11

B= BIRTH**Page 937 of 1107**TABLE A53 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL POSTNATAL SURVIVAL (% PER LITTER)

-------------------------------------------- LITTERS FROM GROUP 5: 10000 PPM

-------------------------------------------- ANIMAL B 0- 1 1- 4 B- 4

----------------------------------------------------------------------------------------------------------------------------------- 91624 100.0 100.0 100.0 100.0 91625 100.0 100.0 100.0 100.0 91627 100.0 100.0 100.0 100.0 91634 100.0 100.0 100.0 100.0 91635 92.3 100.0 100.0 92.3 91638 100.0 100.0 100.0 100.0 91652 84.6 100.0 100.0 84.6 91655 100.0 92.3 91.7 84.6 91658 100.0 100.0 100.0 100.0 91667 100.0 100.0 100.0 100.0 91668 86.7 100.0 100.0 86.7 91680 100.0 100.0 100.0 100.0

MEAN 97.0 99.4 99.3 95.7 S.D. 5.75 2.22 2.41 6.65 S.E. 1.66 0.64 0.69 1.92 N 12 12 12 12

B= BIRTH PPVIASv5.12 02/18/2014**Page 938 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91629-01 M 0 PPM NORMAL 1 11/22/13 12:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91629-01 M 0 PPM DISPOSITION 4 11/25/13 9:31 P SCHEDULED EUTHANASIA 91629-02 M 0 PPM NORMAL 1 11/22/13 12:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91629-02 M 0 PPM DISPOSITION 4 11/25/13 9:31 P SCHEDULED EUTHANASIA 91629-03 M 0 PPM NORMAL 1 11/22/13 12:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91629-03 M 0 PPM DISPOSITION 4 11/25/13 9:31 P SCHEDULED EUTHANASIA 91629-04 M 0 PPM NORMAL 1 11/22/13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91629-04 M 0 PPM DISPOSITION 4 11/25/13 9:31 P SCHEDULED EUTHANASIA 91629-05 M 0 PPM NORMAL 1 11/22/13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91629-05 M 0 PPM DISPOSITION 4 11/25/13 9:31 P SCHEDULED EUTHANASIA 91629-06 M 0 PPM NORMAL 1 11/22/13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91629-06 M 0 PPM DISPOSITION 4 11/25/13 9:31 P SCHEDULED EUTHANASIA 91629-07 M 0 PPM NORMAL 1 11/22/13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91629-07 M 0 PPM DISPOSITION 2 11/23/13 8:22 P FOUND DEAD 91629-08 M 0 PPM NORMAL 1 11/22/13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91629-08 M 0 PPM DISPOSITION 4 11/25/13 9:31 P SCHEDULED EUTHANASIA 91629-09 M 0 PPM NORMAL 1 11/22/13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91629-09 M 0 PPM DISPOSITION 4 11/25/13 9:31 P SCHEDULED EUTHANASIA 91629-10 M 0 PPM NORMAL 1 11/22/13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91629-10 M 0 PPM DISPOSITION 4 11/25/13 9:31 P SCHEDULED EUTHANASIA 91629-11 M 0 PPM NORMAL 1 11/22/13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 939 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91629-11 M 0 PPM NORMAL 4 11/25/13 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91629-11 M 0 PPM DISPOSITION 4 11/25/13 9:31 P SCHEDULED EUTHANASIA 91629-12 M 0 PPM NORMAL 1 11/22/13 12:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91629-12 M 0 PPM DISPOSITION 4 11/25/13 9:31 P SCHEDULED EUTHANASIA 91629-13 F 0 PPM NORMAL 1 11/22/13 12:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91629-13 F 0 PPM DISPOSITION 4 11/25/13 9:31 P SCHEDULED EUTHANASIA 91629-14 F 0 PPM NORMAL 1 11/22/13 12:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91629-14 F 0 PPM DISPOSITION 4 11/25/13 9:31 P SCHEDULED EUTHANASIA 91629-15 F 0 PPM NORMAL 1 11/22/13 12:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91629-15 F 0 PPM DISPOSITION 4 11/25/13 9:31 P SCHEDULED EUTHANASIA 91629-16 F 0 PPM NORMAL 1 11/22/13 12:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91629-16 F 0 PPM DISPOSITION 4 11/25/13 9:31 P SCHEDULED EUTHANASIA

91630-01 M 0 PPM DISPOSITION 0 11/22/13 9:07 P FOUND DEAD 91630-02 M 0 PPM DISPOSITION 0 11/22/13 9:08 P FOUND DEAD 91630-03 M 0 PPM NORMAL 1 11/23/13 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91630-03 M 0 PPM DISPOSITION 4 11/26/13 9:47 P SCHEDULED EUTHANASIA 91630-04 M 0 PPM NORMAL 1 11/23/13 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91630-04 M 0 PPM DISPOSITION 4 11/26/13 9:47 P SCHEDULED EUTHANASIA 91630-05 M 0 PPM NORMAL 1 11/23/13 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91630-05 M 0 PPM DISPOSITION 4 11/26/13 9:47 P SCHEDULED EUTHANASIA 91630-06 M 0 PPM NORMAL 1 11/23/13 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 940 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91630-06 M 0 PPM NORMAL 4 11/26/13 9:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91630-06 M 0 PPM DISPOSITION 4 11/26/13 9:47 P SCHEDULED EUTHANASIA 91630-07 M 0 PPM NORMAL 1 11/23/13 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91630-07 M 0 PPM DISPOSITION 4 11/26/13 9:47 P SCHEDULED EUTHANASIA 91630-08 M 0 PPM NORMAL 1 11/23/13 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91630-08 M 0 PPM DISPOSITION 4 11/26/13 9:47 P SCHEDULED EUTHANASIA 91630-09 F 0 PPM NORMAL 1 11/23/13 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91630-09 F 0 PPM DISPOSITION 4 11/26/13 9:47 P SCHEDULED EUTHANASIA 91630-10 F 0 PPM NORMAL 1 11/23/13 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91630-10 F 0 PPM DISPOSITION 4 11/26/13 9:47 P SCHEDULED EUTHANASIA 91630-11 F 0 PPM NORMAL 1 11/23/13 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91630-11 F 0 PPM DISPOSITION 4 11/26/13 9:47 P SCHEDULED EUTHANASIA 91630-12 F 0 PPM NORMAL 1 11/23/13 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91630-12 F 0 PPM DISPOSITION 4 11/26/13 9:48 P SCHEDULED EUTHANASIA 91630-13 F 0 PPM NORMAL 1 11/23/13 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91630-13 F 0 PPM DISPOSITION 4 11/26/13 9:48 P SCHEDULED EUTHANASIA 91630-14 F 0 PPM NORMAL 1 11/23/13 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91630-14 F 0 PPM DISPOSITION 4 11/26/13 9:48 P SCHEDULED EUTHANASIA

91633-01 M 0 PPM NORMAL 1 11/20/13 11:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91633-01 M 0 PPM DISPOSITION 4 11/23/13 11:59 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 941 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91633-02 M 0 PPM NORMAL 1 11/20/13 11:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91633-02 M 0 PPM DISPOSITION 4 11/23/13 11:59 P SCHEDULED EUTHANASIA 91633-03 M 0 PPM NORMAL 1 11/20/13 11:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91633-03 M 0 PPM DISPOSITION 4 11/23/13 11:59 P SCHEDULED EUTHANASIA 91633-04 M 0 PPM NORMAL 1 11/20/13 11:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91633-04 M 0 PPM DISPOSITION 4 11/23/13 11:59 P SCHEDULED EUTHANASIA 91633-05 M 0 PPM NORMAL 1 11/20/13 11:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91633-05 M 0 PPM DISPOSITION 4 11/23/13 12:00 P SCHEDULED EUTHANASIA 91633-06 M 0 PPM NORMAL 1 11/20/13 11:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91633-06 M 0 PPM DISPOSITION 4 11/23/13 12:00 P SCHEDULED EUTHANASIA 91633-07 M 0 PPM NORMAL 1 11/20/13 11:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91633-07 M 0 PPM DISPOSITION 4 11/23/13 12:00 P SCHEDULED EUTHANASIA 91633-08 F 0 PPM NORMAL 1 11/20/13 11:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91633-08 F 0 PPM DISPOSITION 4 11/23/13 12:00 P SCHEDULED EUTHANASIA 91633-09 F 0 PPM NORMAL 1 11/20/13 11:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91633-09 F 0 PPM DISPOSITION 4 11/23/13 12:00 P SCHEDULED EUTHANASIA 91633-10 F 0 PPM NORMAL 1 11/20/13 11:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91633-10 F 0 PPM DISPOSITION 4 11/23/13 12:00 P SCHEDULED EUTHANASIA 91633-11 F 0 PPM NORMAL 1 11/20/13 11:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91633-11 F 0 PPM DISPOSITION 4 11/23/13 12:01 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 942 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91633-12 F 0 PPM NORMAL 1 11/20/13 11:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91633-12 F 0 PPM DISPOSITION 4 11/23/13 12:01 P SCHEDULED EUTHANASIA 91633-13 F 0 PPM NORMAL 1 11/20/13 11:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91633-13 F 0 PPM DISPOSITION 4 11/23/13 12:01 P SCHEDULED EUTHANASIA 91633-14 F 0 PPM NORMAL 1 11/20/13 11:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91633-14 F 0 PPM DISPOSITION 4 11/23/13 12:01 P SCHEDULED EUTHANASIA 91633-15 F 0 PPM NORMAL 1 11/20/13 11:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91633-15 F 0 PPM DISPOSITION 4 11/23/13 12:01 P SCHEDULED EUTHANASIA

91637-01 M 0 PPM NORMAL 1 11/19/13 9:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/22/13 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91637-01 M 0 PPM DISPOSITION 4 11/22/13 12:44 P SCHEDULED EUTHANASIA 91637-02 M 0 PPM NORMAL 1 11/19/13 9:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/22/13 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91637-02 M 0 PPM DISPOSITION 4 11/22/13 12:45 P SCHEDULED EUTHANASIA 91637-03 M 0 PPM NORMAL 1 11/19/13 9:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/22/13 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91637-03 M 0 PPM DISPOSITION 4 11/22/13 12:45 P SCHEDULED EUTHANASIA 91637-04 M 0 PPM NORMAL 1 11/19/13 9:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS * 4 11/22/13 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91637-04 M 0 PPM DISPOSITION 4 11/22/13 12:45 P SCHEDULED EUTHANASIA 91637-05 M 0 PPM DISPOSITION 3 11/21/13 10:42 P FOUND DEAD 91637-05 M 0 PPM BODY/INTEGUMENT 1 11/19/13 9:29 P SMALL STATURE 91637-06 F 0 PPM NORMAL 1 11/19/13 9:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/22/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91637-06 F 0 PPM DISPOSITION 4 11/22/13 12:45 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY * - LATE COMPUTER ENTRY OBSERVATIONS FOR ABOVE DATES**Page 943 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91637-07 F 0 PPM NORMAL 1 11/19/13 9:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/22/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91637-07 F 0 PPM DISPOSITION 4 11/22/13 12:45 P SCHEDULED EUTHANASIA 91637-08 F 0 PPM NORMAL 1 11/19/13 9:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/22/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91637-08 F 0 PPM DISPOSITION 4 11/22/13 12:45 P SCHEDULED EUTHANASIA 91637-09 F 0 PPM NORMAL 1 11/19/13 9:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/22/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91637-09 F 0 PPM DISPOSITION 4 11/22/13 12:45 P SCHEDULED EUTHANASIA 91637-10 F 0 PPM NORMAL 1 11/19/13 9:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/22/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91637-10 F 0 PPM DISPOSITION 4 11/22/13 12:45 P SCHEDULED EUTHANASIA 91637-11 F 0 PPM NORMAL 1 11/19/13 9:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/22/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91637-11 F 0 PPM DISPOSITION 4 11/22/13 12:45 P SCHEDULED EUTHANASIA 91637-12 F 0 PPM NORMAL 1 11/19/13 9:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/22/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91637-12 F 0 PPM DISPOSITION 4 11/22/13 12:45 P SCHEDULED EUTHANASIA 91637-13 F 0 PPM NORMAL 1 11/19/13 9:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/22/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91637-13 F 0 PPM DISPOSITION 4 11/22/13 12:45 P SCHEDULED EUTHANASIA

91639-01 M 0 PPM DISPOSITION 1 11/22/13 12:47 P FOUND DEAD 91639-01 M 0 PPM BODY/INTEGUMENT 0 11/21/13 13:52 P BODY PALE 0 11/21/13 13:52 P BODY COOL 91639-01 M 0 PPM CARDIO-PULMONARY 0 11/21/13 13:52 P GASPING 91639-02 M 0 PPM NORMAL 1 11/22/13 12:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91639-02 M 0 PPM DISPOSITION 4 11/25/13 9:33 P SCHEDULED EUTHANASIA 91639-03 M 0 PPM NORMAL 1 11/22/13 12:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 944 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91639-03 M 0 PPM NORMAL 4 11/25/13 8:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91639-03 M 0 PPM DISPOSITION 4 11/25/13 9:33 P SCHEDULED EUTHANASIA 91639-04 M 0 PPM NORMAL 1 11/22/13 12:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91639-04 M 0 PPM DISPOSITION 4 11/25/13 9:33 P SCHEDULED EUTHANASIA 91639-05 M 0 PPM NORMAL 1 11/22/13 12:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91639-05 M 0 PPM DISPOSITION 4 11/25/13 9:33 P SCHEDULED EUTHANASIA 91639-06 M 0 PPM NORMAL 1 11/22/13 12:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91639-06 M 0 PPM DISPOSITION 4 11/25/13 9:33 P SCHEDULED EUTHANASIA 91639-07 M 0 PPM NORMAL 1 11/22/13 12:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91639-07 M 0 PPM DISPOSITION 4 11/25/13 9:33 P SCHEDULED EUTHANASIA 91639-08 M 0 PPM NORMAL 1 11/22/13 12:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91639-08 M 0 PPM DISPOSITION 4 11/25/13 9:33 P SCHEDULED EUTHANASIA 91639-09 F 0 PPM NORMAL 1 11/22/13 12:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91639-09 F 0 PPM DISPOSITION 4 11/25/13 9:33 P SCHEDULED EUTHANASIA 91639-10 F 0 PPM NORMAL 1 11/22/13 12:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91639-10 F 0 PPM DISPOSITION 4 11/25/13 9:33 P SCHEDULED EUTHANASIA

91644-01 M 0 PPM NORMAL 1 11/20/13 11:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91644-01 M 0 PPM DISPOSITION 4 11/23/13 12:06 P SCHEDULED EUTHANASIA 91644-02 M 0 PPM NORMAL 1 11/20/13 11:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91644-02 M 0 PPM DISPOSITION 4 11/23/13 12:06 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 945 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91644-03 M 0 PPM NORMAL 1 11/20/13 11:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91644-03 M 0 PPM DISPOSITION 4 11/23/13 12:06 P SCHEDULED EUTHANASIA 91644-04 M 0 PPM NORMAL 1 11/20/13 11:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91644-04 M 0 PPM DISPOSITION 4 11/23/13 12:06 P SCHEDULED EUTHANASIA 91644-05 M 0 PPM NORMAL 1 11/20/13 11:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91644-05 M 0 PPM DISPOSITION 4 11/23/13 12:06 P SCHEDULED EUTHANASIA 91644-06 M 0 PPM NORMAL 1 11/20/13 11:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91644-06 M 0 PPM DISPOSITION 4 11/23/13 12:06 P SCHEDULED EUTHANASIA 91644-07 M 0 PPM NORMAL 1 11/20/13 11:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91644-07 M 0 PPM DISPOSITION 4 11/23/13 12:06 P SCHEDULED EUTHANASIA 91644-08 M 0 PPM NORMAL 1 11/20/13 11:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91644-08 M 0 PPM DISPOSITION 4 11/23/13 12:06 P SCHEDULED EUTHANASIA 91644-09 M 0 PPM NORMAL 1 11/20/13 11:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91644-09 M 0 PPM DISPOSITION 4 11/23/13 12:07 P SCHEDULED EUTHANASIA 91644-10 M 0 PPM NORMAL 1 11/20/13 11:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91644-10 M 0 PPM DISPOSITION 4 11/23/13 12:07 P SCHEDULED EUTHANASIA 91644-11 F 0 PPM NORMAL 1 11/20/13 11:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91644-11 F 0 PPM DISPOSITION 4 11/23/13 12:07 P SCHEDULED EUTHANASIA 91644-12 F 0 PPM NORMAL 1 11/20/13 11:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91644-12 F 0 PPM DISPOSITION 4 11/23/13 12:07 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 946 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91644-13 F 0 PPM NORMAL 1 11/20/13 11:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91644-13 F 0 PPM DISPOSITION 4 11/23/13 12:07 P SCHEDULED EUTHANASIA 91644-14 F 0 PPM NORMAL 1 11/20/13 11:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91644-14 F 0 PPM DISPOSITION 4 11/23/13 12:07 P SCHEDULED EUTHANASIA 91644-15 F 0 PPM NORMAL 1 11/20/13 11:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91644-15 F 0 PPM DISPOSITION 4 11/23/13 12:07 P SCHEDULED EUTHANASIA 91644-16 F 0 PPM NORMAL 1 11/20/13 11:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91644-16 F 0 PPM DISPOSITION 4 11/23/13 12:10 P SCHEDULED EUTHANASIA 91644-17 F 0 PPM NORMAL 1 11/20/13 11:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91644-17 F 0 PPM DISPOSITION 4 11/23/13 8:33 P MISSING

91645-01 M 0 PPM NORMAL 1 11/23/13 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91645-01 M 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA 91645-02 M 0 PPM NORMAL 1 11/23/13 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91645-02 M 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA 91645-03 M 0 PPM NORMAL 1 11/23/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91645-03 M 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA 91645-04 M 0 PPM NORMAL 1 11/23/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91645-04 M 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA 91645-05 M 0 PPM NORMAL 1 11/23/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91645-05 M 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 947 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91645-06 M 0 PPM NORMAL 1 11/23/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91645-06 M 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA 91645-07 M 0 PPM NORMAL 1 11/23/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91645-07 M 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA 91645-08 M 0 PPM DISPOSITION 0 11/22/13 13:39 P FOUND DEAD-A 91645-09 M 0 PPM NORMAL 1 11/23/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91645-09 M 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA 91645-10 F 0 PPM NORMAL 1 11/23/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91645-10 F 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA 91645-11 F 0 PPM NORMAL 1 11/23/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91645-11 F 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA 91645-12 F 0 PPM NORMAL 1 11/23/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91645-12 F 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA 91645-13 F 0 PPM NORMAL 1 11/23/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91645-13 F 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA 91645-14 F 0 PPM NORMAL 1 11/23/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91645-14 F 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA 91645-15 F 0 PPM NORMAL 1 11/23/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91645-15 F 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA 91645-16 F 0 PPM NORMAL 1 11/23/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY A = PUP FOUND DEAD ON PND 0, BUT HAD MILK IN STOMACH; PUP CONSIDERED BORN ALIVE.**Page 948 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 11 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91645-16 F 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA

91648-01 M 0 PPM DISPOSITION 0 11/19/13 13:54 P FOUND DEAD 91648-02 M 0 PPM NORMAL 1 11/20/13 11:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91648-02 M 0 PPM DISPOSITION 4 11/23/13 12:13 P SCHEDULED EUTHANASIA 91648-03 M 0 PPM NORMAL 1 11/20/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91648-03 M 0 PPM DISPOSITION 4 11/23/13 12:13 P SCHEDULED EUTHANASIA 91648-04 M 0 PPM NORMAL 1 11/20/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91648-04 M 0 PPM DISPOSITION 4 11/23/13 12:13 P SCHEDULED EUTHANASIA 91648-05 M 0 PPM NORMAL 1 11/20/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91648-05 M 0 PPM DISPOSITION 4 11/23/13 12:13 P SCHEDULED EUTHANASIA 91648-06 M 0 PPM NORMAL 1 11/20/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91648-06 M 0 PPM DISPOSITION 4 11/23/13 12:13 P SCHEDULED EUTHANASIA 91648-07 M 0 PPM NORMAL 1 11/20/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91648-07 M 0 PPM DISPOSITION 4 11/23/13 12:13 P SCHEDULED EUTHANASIA 91648-08 M 0 PPM NORMAL 1 11/20/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91648-08 M 0 PPM DISPOSITION 4 11/23/13 12:13 P SCHEDULED EUTHANASIA 91648-09 M 0 PPM NORMAL 1 11/20/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91648-09 M 0 PPM DISPOSITION 4 11/23/13 12:13 P SCHEDULED EUTHANASIA 91648-10 F 0 PPM NORMAL 1 11/20/13 11:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91648-10 F 0 PPM DISPOSITION 4 11/23/13 12:13 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 949 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 12 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91648-11 F 0 PPM NORMAL 1 11/20/13 11:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91648-11 F 0 PPM DISPOSITION 4 11/23/13 12:13 P SCHEDULED EUTHANASIA 91648-12 F 0 PPM NORMAL 1 11/20/13 11:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91648-12 F 0 PPM DISPOSITION 4 11/23/13 12:13 P SCHEDULED EUTHANASIA 91648-13 F 0 PPM NORMAL 1 11/20/13 11:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91648-13 F 0 PPM DISPOSITION 4 11/23/13 12:13 P SCHEDULED EUTHANASIA 91648-14 F 0 PPM NORMAL 1 11/20/13 11:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91648-14 F 0 PPM DISPOSITION 4 11/23/13 12:13 P SCHEDULED EUTHANASIA

91653-01 M 0 PPM NORMAL 1 11/22/13 12:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91653-01 M 0 PPM DISPOSITION 4 11/25/13 9:35 P SCHEDULED EUTHANASIA 91653-02 M 0 PPM NORMAL 1 11/22/13 12:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91653-02 M 0 PPM DISPOSITION 4 11/25/13 9:35 P SCHEDULED EUTHANASIA 91653-03 M 0 PPM NORMAL 1 11/22/13 12:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91653-03 M 0 PPM DISPOSITION 4 11/25/13 9:35 P SCHEDULED EUTHANASIA 91653-04 M 0 PPM NORMAL 1 11/22/13 12:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91653-04 M 0 PPM DISPOSITION 4 11/25/13 9:35 P SCHEDULED EUTHANASIA 91653-05 M 0 PPM NORMAL 1 11/22/13 12:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91653-05 M 0 PPM DISPOSITION 4 11/25/13 9:35 P SCHEDULED EUTHANASIA 91653-06 M 0 PPM NORMAL 1 11/22/13 12:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 950 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 13 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91653-06 M 0 PPM DISPOSITION 4 11/25/13 9:35 P SCHEDULED EUTHANASIA 91653-07 F 0 PPM NORMAL 1 11/22/13 12:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91653-07 F 0 PPM DISPOSITION 4 11/25/13 9:35 P SCHEDULED EUTHANASIA 91653-08 F 0 PPM NORMAL 1 11/22/13 12:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91653-08 F 0 PPM DISPOSITION 4 11/25/13 9:35 P SCHEDULED EUTHANASIA 91653-09 F 0 PPM NORMAL 1 11/22/13 12:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91653-09 F 0 PPM DISPOSITION 4 11/25/13 9:35 P SCHEDULED EUTHANASIA 91653-10 F 0 PPM NORMAL 1 11/22/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91653-10 F 0 PPM DISPOSITION 4 11/25/13 9:35 P SCHEDULED EUTHANASIA 91653-11 F 0 PPM NORMAL 1 11/22/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91653-11 F 0 PPM DISPOSITION 4 11/25/13 9:35 P SCHEDULED EUTHANASIA 91653-12 F 0 PPM NORMAL 1 11/22/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91653-12 F 0 PPM DISPOSITION 4 11/25/13 9:35 P SCHEDULED EUTHANASIA 91653-13 F 0 PPM NORMAL 1 11/22/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91653-13 F 0 PPM DISPOSITION 4 11/25/13 9:35 P SCHEDULED EUTHANASIA 91653-14 F 0 PPM NORMAL 1 11/22/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91653-14 F 0 PPM DISPOSITION 4 11/25/13 9:35 P SCHEDULED EUTHANASIA 91653-15 F 0 PPM NORMAL 1 11/22/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91653-15 F 0 PPM DISPOSITION 4 11/25/13 9:35 P SCHEDULED EUTHANASIA

91660-01 M 0 PPM DISPOSITION 0 11/21/13 13:56 P FOUND DEAD

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 951 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 14 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91660-02 M 0 PPM NORMAL 1 11/22/13 12:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91660-02 M 0 PPM DISPOSITION 4 11/25/13 9:37 P SCHEDULED EUTHANASIA 91660-03 M 0 PPM NORMAL 1 11/22/13 12:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91660-03 M 0 PPM DISPOSITION 4 11/25/13 9:37 P SCHEDULED EUTHANASIA 91660-04 M 0 PPM NORMAL 1 11/22/13 12:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91660-04 M 0 PPM DISPOSITION 4 11/25/13 9:37 P SCHEDULED EUTHANASIA 91660-05 M 0 PPM NORMAL 1 11/22/13 12:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91660-05 M 0 PPM DISPOSITION 4 11/25/13 9:37 P SCHEDULED EUTHANASIA 91660-06 M 0 PPM NORMAL 1 11/22/13 12:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91660-06 M 0 PPM DISPOSITION 4 11/25/13 9:37 P SCHEDULED EUTHANASIA 91660-07 M 0 PPM NORMAL 1 11/22/13 12:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91660-07 M 0 PPM DISPOSITION 4 11/25/13 9:37 P SCHEDULED EUTHANASIA 91660-08 M 0 PPM NORMAL 1 11/22/13 12:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91660-08 M 0 PPM DISPOSITION 4 11/25/13 9:37 P SCHEDULED EUTHANASIA 91660-09 M 0 PPM NORMAL 1 11/22/13 12:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91660-09 M 0 PPM DISPOSITION 4 11/25/13 9:37 P SCHEDULED EUTHANASIA 91660-10 F 0 PPM NORMAL 1 11/22/13 12:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91660-10 F 0 PPM DISPOSITION 4 11/25/13 9:37 P SCHEDULED EUTHANASIA 91660-11 F 0 PPM NORMAL 1 11/22/13 12:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91660-11 F 0 PPM DISPOSITION 4 11/25/13 9:37 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 952 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 15 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91660-12 F 0 PPM NORMAL 1 11/22/13 12:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91660-12 F 0 PPM DISPOSITION 4 11/25/13 9:37 P SCHEDULED EUTHANASIA 91660-13 F 0 PPM NORMAL 1 11/22/13 12:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91660-13 F 0 PPM DISPOSITION 4 11/25/13 9:37 P SCHEDULED EUTHANASIA 91660-14 F 0 PPM NORMAL 1 11/22/13 12:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91660-14 F 0 PPM DISPOSITION 4 11/25/13 9:38 P SCHEDULED EUTHANASIA

91670-01 M 0 PPM NORMAL 1 11/23/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91670-01 M 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA 91670-02 M 0 PPM NORMAL 1 11/23/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91670-02 M 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA 91670-03 M 0 PPM NORMAL 1 11/23/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91670-03 M 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA 91670-04 M 0 PPM NORMAL 1 11/23/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91670-04 M 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA 91670-05 M 0 PPM NORMAL 1 11/23/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91670-05 M 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA 91670-06 M 0 PPM NORMAL 1 11/23/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91670-06 M 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA 91670-07 M 0 PPM NORMAL 1 11/23/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 953 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 16 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91670-07 M 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA 91670-08 M 0 PPM NORMAL 1 11/23/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91670-08 M 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA 91670-09 F 0 PPM NORMAL 1 11/23/13 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91670-09 F 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA 91670-10 F 0 PPM NORMAL 1 11/23/13 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91670-10 F 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA 91670-11 F 0 PPM NORMAL 1 11/23/13 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91670-11 F 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA 91670-12 F 0 PPM NORMAL 1 11/23/13 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91670-12 F 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA 91670-13 F 0 PPM NORMAL 1 11/23/13 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91670-13 F 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA 91670-14 F 0 PPM NORMAL 1 11/23/13 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91670-14 F 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA

91672-01 F 0 PPM DISPOSITION 0 11/22/13 9:22 P FOUND DEAD 91672-02 M 0 PPM NORMAL 1 11/23/13 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91672-02 M 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA 91672-03 M 0 PPM NORMAL 1 11/23/13 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91672-03 M 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 954 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 17 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91672-04 M 0 PPM NORMAL 1 11/23/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91672-04 M 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA 91672-05 M 0 PPM NORMAL 1 11/23/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91672-05 M 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA 91672-05 M 0 PPM BODY/INTEGUMENT 4 11/26/13 9:29 P BODY PALE 91672-06 M 0 PPM NORMAL 1 11/23/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91672-06 M 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA 91672-07 M 0 PPM NORMAL 1 11/23/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91672-07 M 0 PPM DISPOSITION 4 11/26/13 9:28 P FOUND DEAD 91672-08 M 0 PPM NORMAL 1 11/23/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91672-08 M 0 PPM DISPOSITION 4 11/26/13 9:51 P SCHEDULED EUTHANASIA 91672-09 F 0 PPM NORMAL 1 11/23/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91672-09 F 0 PPM DISPOSITION 4 11/26/13 9:51 P SCHEDULED EUTHANASIA 91672-10 F 0 PPM NORMAL 1 11/23/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91672-10 F 0 PPM DISPOSITION 4 11/26/13 9:51 P SCHEDULED EUTHANASIA 91672-11 F 0 PPM NORMAL 1 11/23/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91672-11 F 0 PPM DISPOSITION 2 11/24/13 9:37 P FOUND DEAD 91672-12 F 0 PPM NORMAL 1 11/23/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91672-12 F 0 PPM DISPOSITION 4 11/26/13 9:51 P SCHEDULED EUTHANASIA 91672-13 F 0 PPM NORMAL 1 11/23/13 8:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91672-13 F 0 PPM DISPOSITION 4 11/26/13 9:51 P SCHEDULED EUTHANASIA 91672-14 F 0 PPM NORMAL 1 11/23/13 8:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 955 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 18 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91672-14 F 0 PPM DISPOSITION 4 11/26/13 9:51 P SCHEDULED EUTHANASIA

91632-01 M 50 PPM NORMAL 1 11/24/13 10:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91632-01 M 50 PPM DISPOSITION 4 11/27/13 8:04 P SCHEDULED EUTHANASIA 91632-02 M 50 PPM NORMAL 1 11/24/13 10:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91632-02 M 50 PPM DISPOSITION 4 11/27/13 8:04 P SCHEDULED EUTHANASIA 91632-03 M 50 PPM NORMAL 1 11/24/13 10:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91632-03 M 50 PPM DISPOSITION 4 11/27/13 8:04 P SCHEDULED EUTHANASIA 91632-04 M 50 PPM NORMAL 1 11/24/13 10:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91632-04 M 50 PPM DISPOSITION 4 11/27/13 8:04 P SCHEDULED EUTHANASIA 91632-05 F 50 PPM NORMAL 1 11/24/13 10:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91632-05 F 50 PPM DISPOSITION 4 11/27/13 8:04 P SCHEDULED EUTHANASIA 91632-06 F 50 PPM NORMAL 1 11/24/13 10:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91632-06 F 50 PPM DISPOSITION 4 11/27/13 8:04 P SCHEDULED EUTHANASIA 91632-07 F 50 PPM NORMAL 1 11/24/13 10:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91632-07 F 50 PPM DISPOSITION 4 11/27/13 8:04 P SCHEDULED EUTHANASIA 91632-08 F 50 PPM NORMAL 1 11/24/13 10:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91632-08 F 50 PPM DISPOSITION 4 11/27/13 8:04 P SCHEDULED EUTHANASIA 91632-09 F 50 PPM NORMAL 1 11/24/13 10:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91632-09 F 50 PPM DISPOSITION 4 11/27/13 8:04 P SCHEDULED EUTHANASIA 91632-10 F 50 PPM NORMAL 1 11/24/13 10:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 956 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 19 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91632-10 F 50 PPM NORMAL 4 11/27/13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91632-10 F 50 PPM DISPOSITION 4 11/27/13 8:04 P SCHEDULED EUTHANASIA 91632-11 F 50 PPM NORMAL 1 11/24/13 10:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91632-11 F 50 PPM DISPOSITION 4 11/27/13 8:04 P SCHEDULED EUTHANASIA 91632-12 F 50 PPM NORMAL 1 11/24/13 10:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91632-12 F 50 PPM DISPOSITION 4 11/27/13 8:04 P SCHEDULED EUTHANASIA 91632-13 F 50 PPM NORMAL 1 11/24/13 10:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91632-13 F 50 PPM DISPOSITION 4 11/27/13 8:04 P SCHEDULED EUTHANASIA 91632-14 F 50 PPM NORMAL 1 11/24/13 10:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91632-14 F 50 PPM DISPOSITION 4 11/27/13 8:04 P SCHEDULED EUTHANASIA 91632-15 F 50 PPM NORMAL 1 11/24/13 10:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91632-15 F 50 PPM DISPOSITION 2 11/25/13 9:41 P FOUND DEAD

91640-01 M 50 PPM DISPOSITION 0 11/23/13 13:37 P FOUND DEAD 91640-02 M 50 PPM DISPOSITION 0 11/23/13 13:39 P FOUND DEAD 91640-03 F 50 PPM DISPOSITION 4 11/27/13 8:05 P SCHEDULED EUTHANASIA 91640-03 F 50 PPM BODY/INTEGUMENT 0 11/23/13 13:40 P SMALL STATURE 1 11/24/13 10:09 P SMALL STATURE 4 11/27/13 7:58 P SMALL STATURE 91640-04 M 50 PPM NORMAL 1 11/24/13 10:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91640-04 M 50 PPM DISPOSITION 4 11/27/13 8:05 P SCHEDULED EUTHANASIA 91640-05 M 50 PPM NORMAL 1 11/24/13 10:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91640-05 M 50 PPM DISPOSITION 4 11/27/13 8:05 P SCHEDULED EUTHANASIA 91640-06 M 50 PPM NORMAL 1 11/24/13 10:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 957 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 20 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91640-06 M 50 PPM NORMAL 4 11/27/13 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91640-06 M 50 PPM DISPOSITION 4 11/27/13 8:05 P SCHEDULED EUTHANASIA 91640-07 F 50 PPM NORMAL 1 11/24/13 10:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91640-07 F 50 PPM DISPOSITION 4 11/27/13 8:05 P SCHEDULED EUTHANASIA 91640-08 F 50 PPM NORMAL 1 11/24/13 10:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91640-08 F 50 PPM DISPOSITION 4 11/27/13 8:05 P SCHEDULED EUTHANASIA 91640-09 F 50 PPM NORMAL 1 11/24/13 10:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91640-09 F 50 PPM DISPOSITION 4 11/27/13 8:05 P SCHEDULED EUTHANASIA 91640-10 F 50 PPM NORMAL 1 11/24/13 10:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91640-10 F 50 PPM DISPOSITION 4 11/27/13 8:05 P SCHEDULED EUTHANASIA 91640-11 F 50 PPM NORMAL 1 11/24/13 10:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91640-11 F 50 PPM DISPOSITION 4 11/27/13 8:05 P SCHEDULED EUTHANASIA 91640-12 F 50 PPM NORMAL 1 11/24/13 10:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91640-12 F 50 PPM DISPOSITION 4 11/27/13 8:05 P SCHEDULED EUTHANASIA

91642-01 M 50 PPM NORMAL 1 11/21/13 10:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91642-01 M 50 PPM DISPOSITION 4 11/24/13 10:10 P SCHEDULED EUTHANASIA 91642-02 M 50 PPM NORMAL 1 11/21/13 10:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91642-02 M 50 PPM DISPOSITION 4 11/24/13 10:11 P SCHEDULED EUTHANASIA 91642-03 M 50 PPM NORMAL 1 11/21/13 10:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91642-03 M 50 PPM DISPOSITION 4 11/24/13 10:11 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 958 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 21 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91642-04 M 50 PPM NORMAL 1 11/21/13 10:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91642-04 M 50 PPM DISPOSITION 4 11/24/13 10:11 P SCHEDULED EUTHANASIA 91642-05 F 50 PPM NORMAL 1 11/21/13 10:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91642-05 F 50 PPM DISPOSITION 4 11/24/13 10:11 P SCHEDULED EUTHANASIA 91642-06 F 50 PPM NORMAL 1 11/21/13 10:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91642-06 F 50 PPM DISPOSITION 4 11/24/13 10:11 P SCHEDULED EUTHANASIA 91642-07 F 50 PPM NORMAL 1 11/21/13 10:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91642-07 F 50 PPM DISPOSITION 4 11/24/13 10:11 P SCHEDULED EUTHANASIA 91642-08 F 50 PPM NORMAL 1 11/21/13 10:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91642-08 F 50 PPM DISPOSITION 4 11/24/13 10:11 P SCHEDULED EUTHANASIA 91642-09 F 50 PPM NORMAL 1 11/21/13 10:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91642-09 F 50 PPM DISPOSITION 4 11/24/13 10:11 P SCHEDULED EUTHANASIA 91642-10 F 50 PPM NORMAL 1 11/21/13 10:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91642-10 F 50 PPM DISPOSITION 4 11/24/13 10:11 P SCHEDULED EUTHANASIA 91642-11 F 50 PPM NORMAL 1 11/21/13 10:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91642-11 F 50 PPM DISPOSITION 4 11/24/13 10:11 P SCHEDULED EUTHANASIA 91642-12 F 50 PPM NORMAL 1 11/21/13 10:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91642-12 F 50 PPM DISPOSITION 4 11/24/13 10:11 P SCHEDULED EUTHANASIA 91642-12 F 50 PPM BODY/INTEGUMENT 4 11/24/13 8:15 P SMALL STATURE 91642-13 F 50 PPM NORMAL 1 11/21/13 10:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91642-13 F 50 PPM DISPOSITION 4 11/24/13 10:11 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 959 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 22 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91642-14 F 50 PPM NORMAL 1 11/21/13 10:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91642-14 F 50 PPM DISPOSITION 4 11/24/13 10:11 P SCHEDULED EUTHANASIA 91642-15 M 50 PPM NORMAL 1 11/21/13 10:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91642-15 M 50 PPM DISPOSITION 4 11/24/13 10:11 P SCHEDULED EUTHANASIA

91647-01 M 50 PPM DISPOSITION 0 11/22/13 13:49 P FOUND DEAD 91647-02 M 50 PPM DISPOSITION 1 11/23/13 8:50 P MISSING 91647-02 M 50 PPM BODY/INTEGUMENT 0 11/22/13 13:50 P BODY COOL 91647-02 M 50 PPM CARDIO-PULMONARY 0 11/22/13 13:51 P GASPING 91647-03 M 50 PPM NORMAL 1 11/23/13 8:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91647-03 M 50 PPM DISPOSITION 4 11/26/13 9:52 P SCHEDULED EUTHANASIA 91647-04 M 50 PPM NORMAL 1 11/23/13 8:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91647-04 M 50 PPM DISPOSITION 4 11/26/13 9:52 P SCHEDULED EUTHANASIA 91647-05 M 50 PPM NORMAL 1 11/23/13 8:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91647-05 M 50 PPM DISPOSITION 4 11/26/13 9:52 P SCHEDULED EUTHANASIA 91647-06 M 50 PPM NORMAL 1 11/23/13 8:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91647-06 M 50 PPM DISPOSITION 4 11/26/13 9:52 P SCHEDULED EUTHANASIA 91647-07 M 50 PPM NORMAL 1 11/23/13 8:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91647-07 M 50 PPM DISPOSITION 4 11/26/13 9:52 P SCHEDULED EUTHANASIA 91647-08 M 50 PPM NORMAL 1 11/23/13 8:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91647-08 M 50 PPM DISPOSITION 4 11/26/13 9:52 P SCHEDULED EUTHANASIA 91647-09 F 50 PPM NORMAL 1 11/23/13 8:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 960 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 23 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91647-09 F 50 PPM NORMAL 4 11/26/13 9:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91647-09 F 50 PPM DISPOSITION 4 11/26/13 9:52 P SCHEDULED EUTHANASIA 91647-10 F 50 PPM NORMAL 1 11/23/13 8:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91647-10 F 50 PPM DISPOSITION 4 11/26/13 9:52 P SCHEDULED EUTHANASIA 91647-11 F 50 PPM NORMAL 1 11/23/13 8:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91647-11 F 50 PPM DISPOSITION 4 11/26/13 9:52 P SCHEDULED EUTHANASIA 91647-12 F 50 PPM NORMAL 1 11/23/13 8:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91647-12 F 50 PPM DISPOSITION 4 11/26/13 9:52 P SCHEDULED EUTHANASIA 91647-13 F 50 PPM NORMAL 1 11/23/13 8:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91647-13 F 50 PPM DISPOSITION 4 11/26/13 9:52 P SCHEDULED EUTHANASIA

91651-01 M 50 PPM NORMAL 1 11/22/13 13:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91651-01 M 50 PPM DISPOSITION 4 11/25/13 9:44 P SCHEDULED EUTHANASIA 91651-02 M 50 PPM NORMAL 1 11/22/13 13:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91651-02 M 50 PPM DISPOSITION 4 11/25/13 9:44 P SCHEDULED EUTHANASIA 91651-03 M 50 PPM NORMAL 1 11/22/13 13:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91651-03 M 50 PPM DISPOSITION 4 11/25/13 9:44 P SCHEDULED EUTHANASIA 91651-04 M 50 PPM NORMAL 1 11/22/13 13:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91651-04 M 50 PPM DISPOSITION 4 11/25/13 9:44 P SCHEDULED EUTHANASIA 91651-05 M 50 PPM NORMAL 1 11/22/13 13:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91651-05 M 50 PPM DISPOSITION 4 11/25/13 9:44 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 961 of 1107**TABLE A54 (F1)

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----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91651-06 M 50 PPM NORMAL 1 11/22/13 13:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91651-06 M 50 PPM DISPOSITION 4 11/25/13 9:44 P SCHEDULED EUTHANASIA 91651-07 M 50 PPM NORMAL 1 11/22/13 13:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91651-07 M 50 PPM DISPOSITION 4 11/25/13 9:44 P SCHEDULED EUTHANASIA 91651-08 F 50 PPM NORMAL 1 11/22/13 13:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91651-08 F 50 PPM DISPOSITION 4 11/25/13 9:44 P SCHEDULED EUTHANASIA 91651-09 F 50 PPM NORMAL 1 11/22/13 13:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91651-09 F 50 PPM DISPOSITION 4 11/25/13 9:44 P SCHEDULED EUTHANASIA 91651-10 F 50 PPM NORMAL 1 11/22/13 13:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91651-10 F 50 PPM DISPOSITION 4 11/25/13 9:44 P SCHEDULED EUTHANASIA 91651-11 F 50 PPM NORMAL 1 11/22/13 13:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91651-11 F 50 PPM DISPOSITION 4 11/25/13 9:44 P SCHEDULED EUTHANASIA 91651-12 F 50 PPM NORMAL 1 11/22/13 13:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91651-12 F 50 PPM DISPOSITION 4 11/25/13 9:44 P SCHEDULED EUTHANASIA

91659-01 M 50 PPM DISPOSITION 1 11/21/13 10:55 P FOUND DEAD 91659-02 M 50 PPM NORMAL 1 11/21/13 10:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91659-02 M 50 PPM DISPOSITION 4 11/24/13 10:12 P SCHEDULED EUTHANASIA 91659-03 M 50 PPM NORMAL 1 11/21/13 10:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91659-03 M 50 PPM DISPOSITION 4 11/24/13 10:12 P SCHEDULED EUTHANASIA 91659-04 M 50 PPM NORMAL 1 11/21/13 10:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 962 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 25 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91659-04 M 50 PPM NORMAL 4 11/24/13 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91659-04 M 50 PPM DISPOSITION 4 11/24/13 10:12 P SCHEDULED EUTHANASIA 91659-05 M 50 PPM NORMAL 1 11/21/13 10:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91659-05 M 50 PPM DISPOSITION 4 11/24/13 10:12 P SCHEDULED EUTHANASIA 91659-06 M 50 PPM NORMAL 1 11/21/13 10:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91659-06 M 50 PPM DISPOSITION 4 11/24/13 10:12 P SCHEDULED EUTHANASIA 91659-07 M 50 PPM NORMAL 1 11/21/13 10:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91659-07 M 50 PPM DISPOSITION 4 11/24/13 10:12 P SCHEDULED EUTHANASIA 91659-08 F 50 PPM NORMAL 1 11/21/13 10:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91659-08 F 50 PPM DISPOSITION 4 11/24/13 10:12 P SCHEDULED EUTHANASIA 91659-09 F 50 PPM NORMAL 1 11/21/13 10:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91659-09 F 50 PPM DISPOSITION 4 11/24/13 10:13 P SCHEDULED EUTHANASIA 91659-10 F 50 PPM NORMAL 1 11/21/13 10:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91659-10 F 50 PPM DISPOSITION 4 11/24/13 10:13 P SCHEDULED EUTHANASIA 91659-11 F 50 PPM NORMAL 1 11/21/13 10:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91659-11 F 50 PPM DISPOSITION 4 11/24/13 10:13 P SCHEDULED EUTHANASIA 91659-12 F 50 PPM NORMAL 1 11/21/13 10:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91659-12 F 50 PPM DISPOSITION 4 11/24/13 10:13 P SCHEDULED EUTHANASIA 91659-13 F 50 PPM NORMAL 1 11/21/13 10:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91659-13 F 50 PPM DISPOSITION 4 11/24/13 10:13 P SCHEDULED EUTHANASIA

91661-01 M 50 PPM NORMAL 1 11/20/13 11:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 963 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 26 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91661-01 M 50 PPM NORMAL 4 11/23/13 8:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91661-01 M 50 PPM DISPOSITION 4 11/23/13 12:17 P SCHEDULED EUTHANASIA 91661-02 M 50 PPM NORMAL 1 11/20/13 11:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91661-02 M 50 PPM DISPOSITION 4 11/23/13 12:17 P SCHEDULED EUTHANASIA 91661-03 M 50 PPM NORMAL 1 11/20/13 11:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91661-03 M 50 PPM DISPOSITION 4 11/23/13 12:17 P SCHEDULED EUTHANASIA 91661-04 M 50 PPM NORMAL 1 11/20/13 11:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91661-04 M 50 PPM DISPOSITION 4 11/23/13 12:17 P SCHEDULED EUTHANASIA 91661-05 M 50 PPM NORMAL 1 11/20/13 11:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91661-05 M 50 PPM DISPOSITION 4 11/23/13 12:17 P SCHEDULED EUTHANASIA 91661-06 M 50 PPM NORMAL 1 11/20/13 11:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91661-06 M 50 PPM DISPOSITION 4 11/23/13 12:17 P SCHEDULED EUTHANASIA 91661-07 M 50 PPM NORMAL 1 11/20/13 11:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91661-07 M 50 PPM DISPOSITION 4 11/23/13 12:17 P SCHEDULED EUTHANASIA 91661-08 M 50 PPM NORMAL 1 11/20/13 11:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91661-08 M 50 PPM DISPOSITION 4 11/23/13 12:17 P SCHEDULED EUTHANASIA 91661-09 M 50 PPM NORMAL 1 11/20/13 11:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91661-09 M 50 PPM DISPOSITION 4 11/23/13 12:17 P SCHEDULED EUTHANASIA 91661-10 M 50 PPM NORMAL 1 11/20/13 11:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91661-10 M 50 PPM DISPOSITION 4 11/23/13 12:17 P SCHEDULED EUTHANASIA 91661-11 M 50 PPM NORMAL 1 11/20/13 11:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 964 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 27 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91661-11 M 50 PPM NORMAL 4 11/23/13 8:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91661-11 M 50 PPM DISPOSITION 4 11/23/13 12:17 P SCHEDULED EUTHANASIA 91661-12 F 50 PPM NORMAL 1 11/20/13 11:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91661-12 F 50 PPM DISPOSITION 4 11/23/13 12:17 P SCHEDULED EUTHANASIA 91661-13 F 50 PPM DISPOSITION 4 11/23/13 12:17 P SCHEDULED EUTHANASIA 91661-13 F 50 PPM BODY/INTEGUMENT 1 11/20/13 11:40 P SMALL STATURE 4 11/23/13 8:55 P SMALL STATURE 91661-14 F 50 PPM NORMAL 1 11/20/13 11:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91661-14 F 50 PPM DISPOSITION 4 11/23/13 12:17 P SCHEDULED EUTHANASIA 91661-15 F 50 PPM NORMAL 1 11/20/13 11:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91661-15 F 50 PPM DISPOSITION 4 11/23/13 12:17 P SCHEDULED EUTHANASIA 91661-16 F 50 PPM NORMAL 1 11/20/13 11:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91661-16 F 50 PPM DISPOSITION 4 11/23/13 12:18 P SCHEDULED EUTHANASIA 91661-17 F 50 PPM NORMAL 1 11/20/13 11:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 8:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91661-17 F 50 PPM DISPOSITION 4 11/23/13 12:18 P SCHEDULED EUTHANASIA

91663-01 M 50 PPM NORMAL 1 11/22/13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91663-01 M 50 PPM DISPOSITION 4 11/25/13 9:45 P SCHEDULED EUTHANASIA 91663-02 M 50 PPM DISPOSITION 1 11/22/13 13:05 P FOUND DEAD 91663-03 M 50 PPM NORMAL 1 11/22/13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91663-03 M 50 PPM DISPOSITION 4 11/25/13 9:45 P SCHEDULED EUTHANASIA 91663-04 M 50 PPM NORMAL 1 11/22/13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 965 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 28 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91663-04 M 50 PPM DISPOSITION 4 11/25/13 9:45 P SCHEDULED EUTHANASIA 91663-05 M 50 PPM NORMAL 1 11/22/13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91663-05 M 50 PPM DISPOSITION 4 11/25/13 9:45 P SCHEDULED EUTHANASIA 91663-06 M 50 PPM NORMAL 1 11/22/13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91663-06 M 50 PPM DISPOSITION 4 11/25/13 9:45 P SCHEDULED EUTHANASIA 91663-07 M 50 PPM NORMAL 1 11/22/13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91663-07 M 50 PPM DISPOSITION 4 11/25/13 9:45 P SCHEDULED EUTHANASIA 91663-08 F 50 PPM NORMAL 1 11/22/13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91663-08 F 50 PPM DISPOSITION 4 11/25/13 9:45 P SCHEDULED EUTHANASIA 91663-09 F 50 PPM NORMAL 1 11/22/13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91663-09 F 50 PPM DISPOSITION 4 11/25/13 9:45 P SCHEDULED EUTHANASIA 91663-10 F 50 PPM NORMAL 1 11/22/13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91663-10 F 50 PPM DISPOSITION 4 11/25/13 9:45 P SCHEDULED EUTHANASIA 91663-11 F 50 PPM NORMAL 1 11/22/13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91663-11 F 50 PPM DISPOSITION 4 11/25/13 9:45 P SCHEDULED EUTHANASIA 91663-12 F 50 PPM NORMAL 1 11/22/13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91663-12 F 50 PPM DISPOSITION 4 11/25/13 9:45 P SCHEDULED EUTHANASIA 91663-13 F 50 PPM NORMAL 1 11/22/13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91663-13 F 50 PPM DISPOSITION 4 11/25/13 9:45 P SCHEDULED EUTHANASIA 91663-14 F 50 PPM NORMAL 1 11/22/13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91663-14 F 50 PPM DISPOSITION 4 11/25/13 8:34 P FOUND DEAD

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 966 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 29 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91663-15 F 50 PPM NORMAL 1 11/22/13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91663-15 F 50 PPM DISPOSITION 4 11/25/13 9:45 P SCHEDULED EUTHANASIA

91669-01 M 50 PPM NORMAL 1 11/20/13 11:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91669-01 M 50 PPM DISPOSITION 4 11/23/13 12:20 P SCHEDULED EUTHANASIA 91669-02 M 50 PPM NORMAL 1 11/20/13 11:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91669-02 M 50 PPM DISPOSITION 4 11/23/13 12:20 P SCHEDULED EUTHANASIA 91669-03 M 50 PPM NORMAL 1 11/20/13 11:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91669-03 M 50 PPM DISPOSITION 4 11/23/13 12:20 P SCHEDULED EUTHANASIA 91669-04 M 50 PPM NORMAL 1 11/20/13 11:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91669-04 M 50 PPM DISPOSITION 4 11/23/13 12:20 P SCHEDULED EUTHANASIA 91669-05 M 50 PPM NORMAL 1 11/20/13 11:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91669-05 M 50 PPM DISPOSITION 4 11/23/13 8:58 P FOUND DEAD 91669-06 M 50 PPM NORMAL 1 11/20/13 11:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91669-06 M 50 PPM DISPOSITION 4 11/23/13 12:21 P SCHEDULED EUTHANASIA 91669-07 M 50 PPM NORMAL 1 11/20/13 11:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91669-07 M 50 PPM DISPOSITION 4 11/23/13 12:21 P SCHEDULED EUTHANASIA 91669-08 M 50 PPM NORMAL 1 11/20/13 11:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91669-08 M 50 PPM DISPOSITION 4 11/23/13 12:21 P SCHEDULED EUTHANASIA 91669-09 M 50 PPM NORMAL 1 11/20/13 11:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91669-09 M 50 PPM DISPOSITION 4 11/23/13 12:21 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 967 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 30 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91669-10 F 50 PPM NORMAL 1 11/20/13 11:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91669-10 F 50 PPM DISPOSITION 4 11/23/13 12:21 P SCHEDULED EUTHANASIA 91669-11 F 50 PPM NORMAL 1 11/20/13 11:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91669-11 F 50 PPM DISPOSITION 4 11/23/13 8:58 P FOUND DEAD 91669-12 F 50 PPM NORMAL 1 11/20/13 11:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91669-12 F 50 PPM DISPOSITION 4 11/23/13 12:21 P SCHEDULED EUTHANASIA 91669-13 F 50 PPM NORMAL 1 11/20/13 11:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91669-13 F 50 PPM DISPOSITION 4 11/23/13 12:21 P SCHEDULED EUTHANASIA 91669-14 F 50 PPM NORMAL 1 11/20/13 11:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91669-14 F 50 PPM DISPOSITION 4 11/23/13 12:21 P SCHEDULED EUTHANASIA 91669-15 F 50 PPM NORMAL 1 11/20/13 11:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91669-15 F 50 PPM DISPOSITION 4 11/23/13 8:58 P FOUND DEAD 91669-16 F 50 PPM NORMAL 1 11/20/13 11:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91669-16 F 50 PPM DISPOSITION 3 11/22/13 13:08 P FOUND DEAD

91673-01 M 50 PPM NORMAL 1 11/23/13 9:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91673-01 M 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA 91673-02 M 50 PPM NORMAL 1 11/23/13 9:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91673-02 M 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA 91673-03 M 50 PPM NORMAL 1 11/23/13 9:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91673-03 M 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA 91673-04 M 50 PPM NORMAL 1 11/23/13 9:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 968 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 31 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91673-04 M 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA 91673-05 M 50 PPM NORMAL 1 11/23/13 9:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91673-05 M 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA 91673-06 M 50 PPM NORMAL 1 11/23/13 9:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91673-06 M 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA 91673-07 F 50 PPM NORMAL 1 11/23/13 9:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91673-07 F 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA 91673-08 F 50 PPM NORMAL 1 11/23/13 9:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91673-08 F 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA 91673-09 F 50 PPM NORMAL 1 11/23/13 9:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91673-09 F 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA 91673-10 F 50 PPM NORMAL 1 11/23/13 9:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91673-10 F 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA 91673-11 F 50 PPM NORMAL 1 11/23/13 9:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91673-11 F 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA 91673-12 F 50 PPM NORMAL 1 11/23/13 9:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91673-12 F 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA 91673-13 F 50 PPM NORMAL 1 11/23/13 9:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91673-13 F 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA 91673-14 F 50 PPM NORMAL 1 11/23/13 9:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 969 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 32 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91673-14 F 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA 91673-15 F 50 PPM NORMAL 1 11/23/13 9:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91673-15 F 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA 91673-16 F 50 PPM NORMAL 1 11/23/13 9:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91673-16 F 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA

91683-01 M 50 PPM NORMAL 1 11/24/13 10:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91683-01 M 50 PPM DISPOSITION 4 11/27/13 8:06 P SCHEDULED EUTHANASIA 91683-02 M 50 PPM NORMAL 1 11/24/13 10:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91683-02 M 50 PPM DISPOSITION 4 11/27/13 8:06 P SCHEDULED EUTHANASIA 91683-03 M 50 PPM NORMAL 1 11/24/13 10:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91683-03 M 50 PPM DISPOSITION 4 11/27/13 8:06 P SCHEDULED EUTHANASIA 91683-04 M 50 PPM NORMAL 1 11/24/13 10:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91683-04 M 50 PPM DISPOSITION 4 11/27/13 8:06 P SCHEDULED EUTHANASIA 91683-05 M 50 PPM NORMAL 1 11/24/13 10:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91683-05 M 50 PPM DISPOSITION 4 11/27/13 8:06 P SCHEDULED EUTHANASIA 91683-06 M 50 PPM NORMAL 1 11/24/13 10:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91683-06 M 50 PPM DISPOSITION 4 11/27/13 8:06 P SCHEDULED EUTHANASIA 91683-07 F 50 PPM NORMAL 1 11/24/13 10:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91683-07 F 50 PPM DISPOSITION 4 11/27/13 8:06 P SCHEDULED EUTHANASIA 91683-08 F 50 PPM NORMAL 1 11/24/13 10:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 970 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 33 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91683-08 F 50 PPM NORMAL 4 11/27/13 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91683-08 F 50 PPM DISPOSITION 4 11/27/13 8:06 P SCHEDULED EUTHANASIA 91683-09 F 50 PPM NORMAL 1 11/24/13 10:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91683-09 F 50 PPM DISPOSITION 4 11/27/13 8:06 P SCHEDULED EUTHANASIA 91683-10 F 50 PPM NORMAL 1 11/24/13 10:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91683-10 F 50 PPM DISPOSITION 4 11/27/13 8:06 P SCHEDULED EUTHANASIA 91683-11 F 50 PPM NORMAL 1 11/24/13 10:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91683-11 F 50 PPM DISPOSITION 4 11/27/13 8:06 P SCHEDULED EUTHANASIA 91683-12 F 50 PPM NORMAL 1 11/24/13 10:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/27/13 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91683-12 F 50 PPM DISPOSITION 4 11/27/13 8:06 P SCHEDULED EUTHANASIA

91685-01 M 50 PPM NORMAL 1 11/20/13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91685-01 M 50 PPM DISPOSITION 4 11/23/13 12:23 P SCHEDULED EUTHANASIA 91685-02 M 50 PPM NORMAL 1 11/20/13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91685-02 M 50 PPM DISPOSITION 4 11/23/13 12:23 P SCHEDULED EUTHANASIA 91685-03 M 50 PPM NORMAL 1 11/20/13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91685-03 M 50 PPM DISPOSITION 4 11/23/13 12:23 P SCHEDULED EUTHANASIA 91685-04 M 50 PPM NORMAL 1 11/20/13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91685-04 M 50 PPM DISPOSITION 4 11/23/13 12:23 P SCHEDULED EUTHANASIA 91685-05 M 50 PPM NORMAL 1 11/20/13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91685-05 M 50 PPM DISPOSITION 4 11/23/13 12:23 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 971 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 34 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91685-06 F 50 PPM NORMAL 1 11/20/13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91685-06 F 50 PPM DISPOSITION 4 11/23/13 12:23 P SCHEDULED EUTHANASIA 91685-07 F 50 PPM NORMAL 1 11/20/13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91685-07 F 50 PPM DISPOSITION 4 11/23/13 12:23 P SCHEDULED EUTHANASIA 91685-08 F 50 PPM NORMAL 1 11/20/13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91685-08 F 50 PPM DISPOSITION 2 11/21/13 11:06 P MISSING 91685-09 F 50 PPM NORMAL 1 11/20/13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91685-09 F 50 PPM DISPOSITION 4 11/23/13 12:24 P SCHEDULED EUTHANASIA 91685-10 F 50 PPM NORMAL 1 11/20/13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91685-10 F 50 PPM DISPOSITION 4 11/23/13 12:24 P SCHEDULED EUTHANASIA

91620-01 M 100 PPM DISPOSITION 0 11/22/13 9:29 P FOUND DEAD 91620-02 M 100 PPM NORMAL 1 11/23/13 9:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91620-02 M 100 PPM DISPOSITION 4 11/26/13 9:54 P SCHEDULED EUTHANASIA 91620-03 M 100 PPM NORMAL 1 11/23/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91620-03 M 100 PPM DISPOSITION 4 11/26/13 9:54 P SCHEDULED EUTHANASIA 91620-04 M 100 PPM NORMAL 1 11/23/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91620-04 M 100 PPM DISPOSITION 4 11/26/13 9:54 P SCHEDULED EUTHANASIA 91620-05 M 100 PPM NORMAL 1 11/23/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91620-05 M 100 PPM DISPOSITION 4 11/26/13 9:54 P SCHEDULED EUTHANASIA 91620-06 M 100 PPM NORMAL 1 11/23/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 972 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 35 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91620-06 M 100 PPM DISPOSITION 4 11/26/13 9:54 P SCHEDULED EUTHANASIA 91620-07 M 100 PPM NORMAL 1 11/23/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91620-07 M 100 PPM DISPOSITION 4 11/26/13 9:54 P SCHEDULED EUTHANASIA 91620-08 M 100 PPM NORMAL 1 11/23/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91620-08 M 100 PPM DISPOSITION 4 11/26/13 9:54 P SCHEDULED EUTHANASIA 91620-09 M 100 PPM NORMAL 1 11/23/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91620-09 M 100 PPM DISPOSITION 4 11/26/13 9:54 P SCHEDULED EUTHANASIA 91620-10 F 100 PPM NORMAL 1 11/23/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91620-10 F 100 PPM DISPOSITION 4 11/26/13 9:54 P SCHEDULED EUTHANASIA 91620-11 F 100 PPM NORMAL 1 11/23/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91620-11 F 100 PPM DISPOSITION 4 11/26/13 9:54 P SCHEDULED EUTHANASIA 91620-12 F 100 PPM NORMAL 1 11/23/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91620-12 F 100 PPM DISPOSITION 4 11/26/13 9:54 P SCHEDULED EUTHANASIA 91620-13 F 100 PPM NORMAL 1 11/23/13 9:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91620-13 F 100 PPM DISPOSITION 4 11/26/13 9:54 P SCHEDULED EUTHANASIA 91620-14 F 100 PPM NORMAL 1 11/23/13 9:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91620-14 F 100 PPM DISPOSITION 4 11/26/13 9:55 P SCHEDULED EUTHANASIA

91628-01 M 100 PPM DISPOSITION 0 11/20/13 14:07 P FOUND DEAD 91628-02 F 100 PPM NORMAL 4 11/24/13 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91628-02 F 100 PPM DISPOSITION 4 11/24/13 10:18 P SCHEDULED EUTHANASIA 91628-02 F 100 PPM BODY/INTEGUMENT 0 11/20/13 14:07 P SUBCUTANEOUS HEMORRHAGE FACIAL AREA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 973 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 36 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91628-02 F 100 PPM BODY/INTEGUMENT 1 11/21/13 11:09 P SUBCUTANEOUS HEMORRHAGE FACIAL AREA 91628-03 M 100 PPM NORMAL 1 11/21/13 11:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91628-03 M 100 PPM DISPOSITION 4 11/24/13 10:18 P SCHEDULED EUTHANASIA 91628-04 M 100 PPM NORMAL 1 11/21/13 11:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91628-04 M 100 PPM DISPOSITION 4 11/24/13 10:18 P SCHEDULED EUTHANASIA 91628-05 M 100 PPM NORMAL 1 11/21/13 11:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91628-05 M 100 PPM DISPOSITION 4 11/24/13 10:18 P SCHEDULED EUTHANASIA 91628-06 M 100 PPM NORMAL 1 11/21/13 11:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91628-06 M 100 PPM DISPOSITION 4 11/24/13 10:18 P SCHEDULED EUTHANASIA 91628-07 M 100 PPM NORMAL 1 11/21/13 11:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91628-07 M 100 PPM DISPOSITION 4 11/24/13 10:18 P SCHEDULED EUTHANASIA 91628-08 M 100 PPM NORMAL 1 11/21/13 11:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91628-08 M 100 PPM DISPOSITION 4 11/24/13 10:18 P SCHEDULED EUTHANASIA 91628-09 M 100 PPM NORMAL 1 11/21/13 11:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91628-09 M 100 PPM DISPOSITION 4 11/24/13 10:18 P SCHEDULED EUTHANASIA 91628-10 F 100 PPM NORMAL 1 11/21/13 11:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91628-10 F 100 PPM DISPOSITION 4 11/24/13 10:18 P SCHEDULED EUTHANASIA 91628-11 F 100 PPM NORMAL 1 11/21/13 11:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91628-11 F 100 PPM DISPOSITION 4 11/24/13 10:18 P SCHEDULED EUTHANASIA 91628-12 F 100 PPM NORMAL 1 11/21/13 11:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 974 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 37 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91628-12 F 100 PPM DISPOSITION 4 11/24/13 10:18 P SCHEDULED EUTHANASIA 91628-13 F 100 PPM NORMAL 1 11/21/13 11:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91628-13 F 100 PPM DISPOSITION 4 11/24/13 10:18 P SCHEDULED EUTHANASIA 91628-14 F 100 PPM NORMAL 1 11/21/13 11:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91628-14 F 100 PPM DISPOSITION 4 11/24/13 10:18 P SCHEDULED EUTHANASIA 91628-15 F 100 PPM NORMAL 1 11/21/13 11:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91628-15 F 100 PPM DISPOSITION 4 11/24/13 10:18 P SCHEDULED EUTHANASIA

91631-01 M 100 PPM NORMAL 1 11/21/13 11:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91631-01 M 100 PPM DISPOSITION 3 11/23/13 9:15 P FOUND DEAD 91631-02 M 100 PPM NORMAL 1 11/21/13 11:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91631-02 M 100 PPM DISPOSITION 4 11/24/13 10:19 P SCHEDULED EUTHANASIA 91631-03 M 100 PPM NORMAL 1 11/21/13 11:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91631-03 M 100 PPM DISPOSITION 4 11/24/13 10:19 P SCHEDULED EUTHANASIA 91631-04 M 100 PPM NORMAL 1 11/21/13 11:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91631-04 M 100 PPM DISPOSITION 4 11/24/13 10:19 P SCHEDULED EUTHANASIA 91631-05 M 100 PPM NORMAL 1 11/21/13 11:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91631-05 M 100 PPM DISPOSITION 4 11/24/13 10:19 P SCHEDULED EUTHANASIA 91631-06 M 100 PPM NORMAL 1 11/21/13 11:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91631-06 M 100 PPM DISPOSITION 4 11/24/13 10:19 P SCHEDULED EUTHANASIA 91631-07 M 100 PPM NORMAL 1 11/21/13 11:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 975 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 38 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91631-07 M 100 PPM DISPOSITION 4 11/24/13 10:19 P SCHEDULED EUTHANASIA 91631-08 M 100 PPM DISPOSITION 2 11/22/13 13:10 P FOUND DEAD 91631-08 M 100 PPM BODY/INTEGUMENT 1 11/21/13 11:14 P SMALL STATURE 91631-09 M 100 PPM NORMAL 1 11/21/13 11:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91631-09 M 100 PPM DISPOSITION 4 11/24/13 10:19 P SCHEDULED EUTHANASIA 91631-10 F 100 PPM NORMAL 1 11/21/13 11:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91631-10 F 100 PPM DISPOSITION 4 11/24/13 10:19 P SCHEDULED EUTHANASIA 91631-11 F 100 PPM NORMAL 1 11/21/13 11:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91631-11 F 100 PPM DISPOSITION 4 11/24/13 10:19 P SCHEDULED EUTHANASIA 91631-12 F 100 PPM NORMAL 1 11/21/13 11:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91631-12 F 100 PPM DISPOSITION 4 11/24/13 10:19 P SCHEDULED EUTHANASIA 91631-13 F 100 PPM NORMAL 1 11/21/13 11:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91631-13 F 100 PPM DISPOSITION 4 11/24/13 10:19 P SCHEDULED EUTHANASIA 91631-14 F 100 PPM NORMAL 1 11/21/13 11:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91631-14 F 100 PPM DISPOSITION 4 11/24/13 10:19 P SCHEDULED EUTHANASIA 91631-15 F 100 PPM NORMAL 1 11/21/13 11:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91631-15 F 100 PPM DISPOSITION 4 11/24/13 10:19 P SCHEDULED EUTHANASIA

91636-01 M 100 PPM NORMAL 1 11/22/13 13:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91636-01 M 100 PPM DISPOSITION 4 11/25/13 9:48 P SCHEDULED EUTHANASIA 91636-02 M 100 PPM NORMAL 1 11/22/13 13:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 976 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 39 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91636-02 M 100 PPM DISPOSITION 4 11/25/13 9:48 P SCHEDULED EUTHANASIA 91636-03 M 100 PPM NORMAL 1 11/22/13 13:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91636-03 M 100 PPM DISPOSITION 4 11/25/13 9:48 P SCHEDULED EUTHANASIA 91636-04 M 100 PPM NORMAL 1 11/22/13 13:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91636-04 M 100 PPM DISPOSITION 4 11/25/13 9:48 P SCHEDULED EUTHANASIA 91636-05 F 100 PPM NORMAL 1 11/22/13 13:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91636-05 F 100 PPM DISPOSITION 4 11/25/13 9:48 P SCHEDULED EUTHANASIA 91636-06 F 100 PPM NORMAL 1 11/22/13 13:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91636-06 F 100 PPM DISPOSITION 4 11/25/13 9:48 P SCHEDULED EUTHANASIA 91636-07 F 100 PPM NORMAL 1 11/22/13 13:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91636-07 F 100 PPM DISPOSITION 4 11/25/13 9:48 P SCHEDULED EUTHANASIA 91636-08 F 100 PPM NORMAL 1 11/22/13 13:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91636-08 F 100 PPM DISPOSITION 4 11/25/13 9:48 P SCHEDULED EUTHANASIA 91636-09 F 100 PPM NORMAL 1 11/22/13 13:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91636-09 F 100 PPM DISPOSITION 4 11/25/13 9:48 P SCHEDULED EUTHANASIA 91636-10 F 100 PPM NORMAL 1 11/22/13 13:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91636-10 F 100 PPM DISPOSITION 4 11/25/13 9:48 P SCHEDULED EUTHANASIA 91636-11 F 100 PPM NORMAL 1 11/22/13 13:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91636-11 F 100 PPM DISPOSITION 4 11/25/13 9:48 P SCHEDULED EUTHANASIA 91636-12 F 100 PPM NORMAL 1 11/22/13 13:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 977 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 40 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91636-12 F 100 PPM DISPOSITION 4 11/25/13 9:48 P SCHEDULED EUTHANASIA 91636-13 F 100 PPM NORMAL 1 11/22/13 13:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91636-13 F 100 PPM DISPOSITION 4 11/25/13 9:48 P SCHEDULED EUTHANASIA

91649-01 M 100 PPM NORMAL 1 11/20/13 11:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91649-01 M 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA 91649-02 M 100 PPM NORMAL 1 11/20/13 11:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91649-02 M 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA 91649-03 M 100 PPM NORMAL 1 11/20/13 11:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91649-03 M 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA 91649-04 M 100 PPM NORMAL 1 11/20/13 11:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91649-04 M 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA 91649-05 M 100 PPM NORMAL 1 11/20/13 11:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91649-05 M 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA 91649-06 M 100 PPM NORMAL 1 11/20/13 11:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91649-06 M 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA 91649-07 F 100 PPM NORMAL 1 11/20/13 11:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91649-07 F 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA 91649-08 F 100 PPM NORMAL 1 11/20/13 11:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91649-08 F 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA 91649-09 F 100 PPM NORMAL 1 11/20/13 11:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 978 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 41 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91649-09 F 100 PPM NORMAL 4 11/23/13 9:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91649-09 F 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA 91649-10 F 100 PPM NORMAL 1 11/20/13 11:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91649-10 F 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA 91649-11 F 100 PPM NORMAL 1 11/20/13 11:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91649-11 F 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA 91649-12 F 100 PPM NORMAL 1 11/20/13 11:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91649-12 F 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA 91649-13 F 100 PPM NORMAL 1 11/20/13 11:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91649-13 F 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA 91649-14 F 100 PPM NORMAL 1 11/20/13 11:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91649-14 F 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA * 91649-15 F 100 PPM NORMAL 1 11/20/13 11:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91649-15 F 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA 91649-16 F 100 PPM NORMAL 1 11/20/13 11:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91649-16 F 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA

91650-01 M 100 PPM DISPOSITION 0 11/19/13 14:25 P FOUND DEAD 91650-02 M 100 PPM NORMAL 1 11/20/13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91650-02 M 100 PPM DISPOSITION 4 11/23/13 12:31 P SCHEDULED EUTHANASIA 91650-03 M 100 PPM NORMAL 1 11/20/13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY * - LATE COMPUTER ENTRY OBSERVATIONS FOR ABOVE DATES**Page 979 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 42 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91650-03 M 100 PPM DISPOSITION 4 11/23/13 12:31 P SCHEDULED EUTHANASIA 91650-04 M 100 PPM NORMAL 1 11/20/13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91650-04 M 100 PPM DISPOSITION 4 11/23/13 12:31 P SCHEDULED EUTHANASIA 91650-05 M 100 PPM NORMAL 4 11/23/13 9:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91650-05 M 100 PPM DISPOSITION 4 11/23/13 12:31 P SCHEDULED EUTHANASIA 91650-05 M 100 PPM BODY/INTEGUMENT 1 11/20/13 11:57 P BODY PALE 91650-06 M 100 PPM NORMAL 1 11/20/13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91650-06 M 100 PPM DISPOSITION 4 11/23/13 12:31 P SCHEDULED EUTHANASIA 91650-07 M 100 PPM NORMAL 1 11/20/13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91650-07 M 100 PPM DISPOSITION 4 11/23/13 12:31 P SCHEDULED EUTHANASIA 91650-08 M 100 PPM NORMAL 1 11/20/13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91650-08 M 100 PPM DISPOSITION 4 11/23/13 12:31 P SCHEDULED EUTHANASIA 91650-09 F 100 PPM NORMAL 1 11/20/13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91650-09 F 100 PPM DISPOSITION 4 11/23/13 12:31 P SCHEDULED EUTHANASIA 91650-10 F 100 PPM NORMAL 1 11/20/13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91650-10 F 100 PPM DISPOSITION 4 11/23/13 12:31 P SCHEDULED EUTHANASIA 91650-11 F 100 PPM NORMAL 1 11/20/13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91650-11 F 100 PPM DISPOSITION 4 11/23/13 12:31 P SCHEDULED EUTHANASIA 91650-12 F 100 PPM DISPOSITION 4 11/23/13 12:31 P SCHEDULED EUTHANASIA 91650-12 F 100 PPM BODY/INTEGUMENT 1 11/20/13 11:59 P SMALL STATURE 4 11/23/13 9:23 P SMALL STATURE 91650-13 F 100 PPM NORMAL 1 11/20/13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 980 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 43 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91650-13 F 100 PPM DISPOSITION 4 11/23/13 12:32 P SCHEDULED EUTHANASIA 91650-14 F 100 PPM NORMAL 1 11/20/13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91650-14 F 100 PPM DISPOSITION 4 11/23/13 12:32 P SCHEDULED EUTHANASIA

91656-01 F 100 PPM DISPOSITION 0 11/24/13 13:38 P FOUND DEAD 91656-02 M 100 PPM DISPOSITION 1 11/25/13 9:58 P MISSING 91656-02 M 100 PPM BODY/INTEGUMENT 0 11/24/13 13:38 P CYANOTIC 91656-03 M 100 PPM NORMAL 1 11/25/13 9:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/28/13 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91656-03 M 100 PPM DISPOSITION 4 11/28/13 7:57 P SCHEDULED EUTHANASIA 91656-04 M 100 PPM NORMAL 1 11/25/13 9:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/28/13 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91656-04 M 100 PPM DISPOSITION 4 11/28/13 7:57 P SCHEDULED EUTHANASIA 91656-05 M 100 PPM DISPOSITION 1 11/25/13 10:00 P MISSING 91656-06 M 100 PPM NORMAL 1 11/25/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/28/13 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91656-06 M 100 PPM DISPOSITION 4 11/28/13 7:57 P SCHEDULED EUTHANASIA 91656-07 M 100 PPM NORMAL 1 11/25/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/28/13 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91656-07 M 100 PPM DISPOSITION 4 11/28/13 7:57 P SCHEDULED EUTHANASIA 91656-08 F 100 PPM NORMAL 1 11/25/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/28/13 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91656-08 F 100 PPM DISPOSITION 4 11/28/13 7:57 P SCHEDULED EUTHANASIA 91656-09 F 100 PPM NORMAL 1 11/25/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/28/13 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91656-09 F 100 PPM DISPOSITION 4 11/28/13 7:57 P SCHEDULED EUTHANASIA 91656-10 F 100 PPM NORMAL 1 11/25/13 10:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/28/13 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91656-10 F 100 PPM DISPOSITION 4 11/28/13 7:57 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 981 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 44 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91656-11 F 100 PPM NORMAL 1 11/25/13 10:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/28/13 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91656-11 F 100 PPM DISPOSITION 4 11/28/13 7:57 P SCHEDULED EUTHANASIA 91656-12 F 100 PPM NORMAL 1 11/25/13 10:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS * 4 11/28/13 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91656-12 F 100 PPM DISPOSITION 4 11/28/13 7:57 P SCHEDULED EUTHANASIA 91656-13 F 100 PPM NORMAL 1 11/25/13 10:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/28/13 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91656-13 F 100 PPM DISPOSITION 4 11/28/13 7:57 P SCHEDULED EUTHANASIA 91656-14 F 100 PPM NORMAL 1 11/25/13 10:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91656-14 F 100 PPM DISPOSITION 3 11/27/13 8:09 P MISSING 91656-15 F 100 PPM NORMAL 1 11/25/13 10:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS * 4 11/28/13 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91656-15 F 100 PPM DISPOSITION 4 11/28/13 7:57 P SCHEDULED EUTHANASIA

91671-01 M 100 PPM DISPOSITION 0 11/24/13 8:00 P FOUND DEAD 91671-02 F 100 PPM DISPOSITION 0 11/24/13 8:00 P FOUND DEAD 91671-03 M 100 PPM NORMAL 1 11/25/13 10:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/28/13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91671-03 M 100 PPM DISPOSITION 4 11/28/13 7:58 P SCHEDULED EUTHANASIA 91671-04 M 100 PPM NORMAL 1 11/25/13 10:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/28/13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91671-04 M 100 PPM DISPOSITION 4 11/28/13 7:58 P SCHEDULED EUTHANASIA 91671-05 M 100 PPM NORMAL 1 11/25/13 10:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/28/13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91671-05 M 100 PPM DISPOSITION 4 11/28/13 7:58 P SCHEDULED EUTHANASIA 91671-06 M 100 PPM NORMAL 1 11/25/13 10:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS * 4 11/28/13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91671-06 M 100 PPM DISPOSITION 4 11/28/13 7:58 P SCHEDULED EUTHANASIA 91671-07 M 100 PPM DISPOSITION 1 11/25/13 10:07 P MISSING *

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY * - LATE COMPUTER ENTRY OBSERVATIONS FOR ABOVE DATES**Page 982 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 45 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91671-08 M 100 PPM NORMAL 1 11/25/13 10:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/28/13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91671-08 M 100 PPM DISPOSITION 4 11/28/13 7:58 P SCHEDULED EUTHANASIA 91671-09 M 100 PPM NORMAL 1 11/25/13 10:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/28/13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91671-09 M 100 PPM DISPOSITION 4 11/28/13 7:59 P SCHEDULED EUTHANASIA 91671-10 F 100 PPM NORMAL 1 11/25/13 10:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/28/13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91671-10 F 100 PPM DISPOSITION 4 11/28/13 7:59 P SCHEDULED EUTHANASIA 91671-11 F 100 PPM DISPOSITION 1 11/25/13 10:07 P FOUND DEAD 91671-12 F 100 PPM NORMAL 1 11/25/13 10:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/28/13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91671-12 F 100 PPM DISPOSITION 4 11/28/13 7:59 P SCHEDULED EUTHANASIA 91671-13 F 100 PPM NORMAL 1 11/25/13 10:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/28/13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91671-13 F 100 PPM DISPOSITION 4 11/28/13 7:59 P SCHEDULED EUTHANASIA 91671-14 F 100 PPM NORMAL 1 11/25/13 10:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/28/13 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91671-14 F 100 PPM DISPOSITION 4 11/28/13 7:59 P SCHEDULED EUTHANASIA 91671-15 F 100 PPM NORMAL 1 11/25/13 10:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/28/13 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91671-15 F 100 PPM DISPOSITION 4 11/28/13 7:59 P SCHEDULED EUTHANASIA

91675-01 M 100 PPM NORMAL 1 11/21/13 11:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91675-01 M 100 PPM DISPOSITION 4 11/24/13 10:20 P SCHEDULED EUTHANASIA 91675-02 M 100 PPM NORMAL 1 11/21/13 11:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91675-02 M 100 PPM DISPOSITION 4 11/24/13 10:20 P SCHEDULED EUTHANASIA 91675-03 M 100 PPM NORMAL 1 11/21/13 11:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 983 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 46 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91675-03 M 100 PPM NORMAL 4 11/24/13 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91675-03 M 100 PPM DISPOSITION 4 11/24/13 10:20 P SCHEDULED EUTHANASIA 91675-04 M 100 PPM DISPOSITION 1 11/21/13 11:20 P FOUND DEAD 91675-05 M 100 PPM NORMAL 1 11/21/13 11:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91675-05 M 100 PPM DISPOSITION 4 11/24/13 10:20 P SCHEDULED EUTHANASIA 91675-06 F 100 PPM NORMAL 1 11/21/13 11:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91675-06 F 100 PPM DISPOSITION 4 11/24/13 10:20 P SCHEDULED EUTHANASIA 91675-07 F 100 PPM NORMAL 1 11/21/13 11:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91675-07 F 100 PPM DISPOSITION 4 11/24/13 10:20 P SCHEDULED EUTHANASIA 91675-08 F 100 PPM NORMAL 1 11/21/13 11:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91675-08 F 100 PPM DISPOSITION 4 11/24/13 10:21 P SCHEDULED EUTHANASIA 91675-09 F 100 PPM NORMAL 1 11/21/13 11:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91675-09 F 100 PPM DISPOSITION 4 11/24/13 10:21 P SCHEDULED EUTHANASIA 91675-10 F 100 PPM NORMAL 1 11/21/13 11:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91675-10 F 100 PPM DISPOSITION 4 11/24/13 10:21 P SCHEDULED EUTHANASIA 91675-11 F 100 PPM NORMAL 1 11/21/13 11:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91675-11 F 100 PPM DISPOSITION 4 11/24/13 8:31 P FOUND DEAD 91675-12 F 100 PPM NORMAL 1 11/21/13 11:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91675-12 F 100 PPM DISPOSITION 4 11/24/13 10:21 P SCHEDULED EUTHANASIA 91675-13 F 100 PPM NORMAL 1 11/21/13 11:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91675-13 F 100 PPM DISPOSITION 4 11/24/13 10:21 P SCHEDULED EUTHANASIA 91675-14 F 100 PPM NORMAL 1 11/21/13 11:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 984 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 47 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91675-14 F 100 PPM DISPOSITION 2 11/22/13 13:17 P MISSING

91677-01 M 100 PPM NORMAL 1 11/22/13 13:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91677-01 M 100 PPM DISPOSITION 3 11/24/13 10:22 P FOUND DEAD 91677-02 M 100 PPM NORMAL 1 11/22/13 13:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91677-02 M 100 PPM DISPOSITION 4 11/25/13 10:13 P SCHEDULED EUTHANASIA 91677-03 F 100 PPM NORMAL 1 11/22/13 13:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91677-03 F 100 PPM DISPOSITION 4 11/25/13 10:13 P SCHEDULED EUTHANASIA 91677-04 F 100 PPM NORMAL 1 11/22/13 13:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91677-04 F 100 PPM DISPOSITION 3 11/24/13 10:22 P MISSING 91677-05 F 100 PPM NORMAL 1 11/22/13 13:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91677-05 F 100 PPM DISPOSITION 4 11/25/13 10:13 P SCHEDULED EUTHANASIA

91679-01 M 100 PPM DISPOSITION 0 11/19/13 14:28 P FOUND DEAD 91679-02 F 100 PPM DISPOSITION 0 11/19/13 14:28 P FOUND DEAD 91679-03 M 100 PPM NORMAL 1 11/20/13 12:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91679-03 M 100 PPM DISPOSITION 4 11/23/13 12:34 P SCHEDULED EUTHANASIA 91679-04 M 100 PPM NORMAL 1 11/20/13 12:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91679-04 M 100 PPM DISPOSITION 4 11/23/13 12:34 P SCHEDULED EUTHANASIA 91679-05 M 100 PPM NORMAL 1 11/20/13 12:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91679-05 M 100 PPM DISPOSITION 4 11/23/13 12:34 P SCHEDULED EUTHANASIA 91679-06 M 100 PPM NORMAL 1 11/20/13 12:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91679-06 M 100 PPM DISPOSITION 2 11/21/13 11:28 P MISSING 91679-07 M 100 PPM NORMAL 1 11/20/13 12:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 985 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 48 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91679-07 M 100 PPM NORMAL 4 11/23/13 9:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91679-07 M 100 PPM DISPOSITION 4 11/23/13 12:34 P SCHEDULED EUTHANASIA 91679-08 M 100 PPM NORMAL 1 11/20/13 12:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91679-08 M 100 PPM DISPOSITION 4 11/23/13 12:34 P SCHEDULED EUTHANASIA 91679-09 F 100 PPM NORMAL 1 11/20/13 12:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91679-09 F 100 PPM DISPOSITION 4 11/23/13 12:34 P SCHEDULED EUTHANASIA 91679-10 F 100 PPM NORMAL 1 11/20/13 12:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91679-10 F 100 PPM DISPOSITION 2 11/21/13 11:28 P FOUND DEAD 91679-11 F 100 PPM DISPOSITION 1 11/20/13 12:06 P FOUND DEAD 91679-12 F 100 PPM NORMAL 1 11/20/13 12:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91679-12 F 100 PPM DISPOSITION 4 11/23/13 12:34 P SCHEDULED EUTHANASIA

91684-01 M 100 PPM NORMAL 1 11/21/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91684-01 M 100 PPM DISPOSITION 4 11/24/13 10:24 P SCHEDULED EUTHANASIA 91684-02 M 100 PPM NORMAL 1 11/21/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91684-02 M 100 PPM DISPOSITION 4 11/24/13 10:24 P SCHEDULED EUTHANASIA 91684-03 M 100 PPM NORMAL 1 11/21/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91684-03 M 100 PPM DISPOSITION 4 11/24/13 10:24 P SCHEDULED EUTHANASIA 91684-04 M 100 PPM NORMAL 1 11/21/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91684-04 M 100 PPM DISPOSITION 4 11/24/13 10:24 P SCHEDULED EUTHANASIA 91684-05 M 100 PPM NORMAL 1 11/21/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91684-05 M 100 PPM DISPOSITION 4 11/24/13 10:24 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 986 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 49 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91684-06 M 100 PPM NORMAL 1 11/21/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91684-06 M 100 PPM DISPOSITION 4 11/24/13 10:24 P SCHEDULED EUTHANASIA 91684-07 M 100 PPM NORMAL 1 11/21/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91684-07 M 100 PPM DISPOSITION 4 11/24/13 10:24 P SCHEDULED EUTHANASIA 91684-08 M 100 PPM NORMAL 1 11/21/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91684-08 M 100 PPM DISPOSITION 4 11/24/13 10:24 P SCHEDULED EUTHANASIA 91684-09 M 100 PPM NORMAL 1 11/21/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91684-09 M 100 PPM DISPOSITION 4 11/24/13 10:24 P SCHEDULED EUTHANASIA 91684-10 F 100 PPM NORMAL 1 11/21/13 11:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91684-10 F 100 PPM DISPOSITION 4 11/24/13 10:24 P SCHEDULED EUTHANASIA 91684-11 F 100 PPM NORMAL 1 11/21/13 11:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91684-11 F 100 PPM DISPOSITION 4 11/24/13 10:24 P SCHEDULED EUTHANASIA 91684-12 F 100 PPM NORMAL 1 11/21/13 11:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91684-12 F 100 PPM DISPOSITION 4 11/24/13 10:24 P SCHEDULED EUTHANASIA 91684-13 F 100 PPM NORMAL 1 11/21/13 11:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91684-13 F 100 PPM DISPOSITION 4 11/24/13 10:24 P SCHEDULED EUTHANASIA 91684-14 F 100 PPM NORMAL 1 11/21/13 11:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91684-14 F 100 PPM DISPOSITION 4 11/24/13 10:24 P SCHEDULED EUTHANASIA 91684-15 F 100 PPM NORMAL 1 11/21/13 11:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91684-15 F 100 PPM DISPOSITION 4 11/24/13 10:25 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 987 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 50 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91684-16 F 100 PPM NORMAL 1 11/21/13 11:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91684-16 F 100 PPM DISPOSITION 4 11/24/13 10:25 P SCHEDULED EUTHANASIA

91622-01 M 175 PPM DISPOSITION 1 11/20/13 7:12 P FOUND DEAD 91622-02 M 175 PPM DISPOSITION 1 11/20/13 7:12 P FOUND DEAD 91622-03 F 175 PPM DISPOSITION 1 11/20/13 7:12 P FOUND DEAD 91622-04 M 175 PPM NORMAL 1 11/20/13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91622-04 M 175 PPM DISPOSITION 4 11/23/13 12:37 P SCHEDULED EUTHANASIA 91622-05 M 175 PPM NORMAL 1 11/20/13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91622-05 M 175 PPM DISPOSITION 4 11/23/13 12:37 P SCHEDULED EUTHANASIA 91622-06 M 175 PPM NORMAL 4 11/23/13 9:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91622-06 M 175 PPM DISPOSITION 4 11/23/13 12:37 P SCHEDULED EUTHANASIA 91622-06 M 175 PPM BODY/INTEGUMENT 1 11/20/13 12:15 P SUBCUTANEOUS HEMORRHAGE FACIAL AREA 91622-07 M 175 PPM NORMAL 1 11/20/13 12:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91622-07 M 175 PPM DISPOSITION 4 11/23/13 12:37 P SCHEDULED EUTHANASIA 91622-08 M 175 PPM NORMAL 1 11/20/13 12:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91622-08 M 175 PPM DISPOSITION 2 11/21/13 11:36 P FOUND DEAD 91622-09 M 175 PPM NORMAL 1 11/20/13 12:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91622-09 M 175 PPM DISPOSITION 4 11/23/13 12:38 P SCHEDULED EUTHANASIA 91622-10 M 175 PPM NORMAL 1 11/20/13 12:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91622-10 M 175 PPM DISPOSITION 4 11/23/13 12:38 P SCHEDULED EUTHANASIA 91622-10 M 175 PPM BODY/INTEGUMENT 4 11/23/13 9:31 P SUBCUTANEOUS HEMORRHAGE DORSAL HEAD 91622-11 F 175 PPM NORMAL 1 11/20/13 12:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91622-11 F 175 PPM DISPOSITION 4 11/23/13 12:38 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 988 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 51 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91622-12 F 175 PPM NORMAL 1 11/20/13 12:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91622-12 F 175 PPM DISPOSITION 4 11/23/13 12:38 P SCHEDULED EUTHANASIA 91622-13 F 175 PPM NORMAL 1 11/20/13 12:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91622-13 F 175 PPM DISPOSITION 2 11/21/13 11:36 P FOUND DEAD 91622-14 F 175 PPM NORMAL 1 11/20/13 12:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91622-14 F 175 PPM DISPOSITION 3 11/22/13 13:22 P FOUND DEAD

91626-01 F 175 PPM DISPOSITION 1 11/23/13 9:33 P FOUND DEAD 91626-01 F 175 PPM BODY/INTEGUMENT 0 11/22/13 14:08 P SMALL STATURE 91626-02 M 175 PPM NORMAL 1 11/23/13 9:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91626-02 M 175 PPM DISPOSITION 4 11/26/13 9:56 P SCHEDULED EUTHANASIA 91626-03 M 175 PPM NORMAL 1 11/23/13 9:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91626-03 M 175 PPM DISPOSITION 4 11/26/13 9:56 P SCHEDULED EUTHANASIA 91626-04 M 175 PPM NORMAL 1 11/23/13 9:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91626-04 M 175 PPM DISPOSITION 4 11/26/13 9:56 P SCHEDULED EUTHANASIA 91626-05 M 175 PPM NORMAL 1 11/23/13 9:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91626-05 M 175 PPM DISPOSITION 4 11/26/13 9:56 P SCHEDULED EUTHANASIA 91626-06 M 175 PPM NORMAL 1 11/23/13 9:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91626-06 M 175 PPM DISPOSITION 4 11/26/13 9:56 P SCHEDULED EUTHANASIA 91626-07 M 175 PPM NORMAL 1 11/23/13 9:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91626-07 M 175 PPM DISPOSITION 4 11/26/13 9:56 P SCHEDULED EUTHANASIA 91626-08 F 175 PPM NORMAL 1 11/23/13 9:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 989 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 52 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91626-08 F 175 PPM DISPOSITION 4 11/26/13 9:56 P SCHEDULED EUTHANASIA 91626-09 F 175 PPM NORMAL 1 11/23/13 9:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91626-09 F 175 PPM DISPOSITION 4 11/26/13 9:56 P SCHEDULED EUTHANASIA 91626-10 F 175 PPM NORMAL 1 11/23/13 9:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91626-10 F 175 PPM DISPOSITION 4 11/26/13 9:56 P SCHEDULED EUTHANASIA 91626-11 F 175 PPM NORMAL 1 11/23/13 9:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91626-11 F 175 PPM DISPOSITION 4 11/26/13 9:56 P SCHEDULED EUTHANASIA 91626-12 F 175 PPM NORMAL 1 11/23/13 9:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91626-12 F 175 PPM DISPOSITION 4 11/26/13 9:56 P SCHEDULED EUTHANASIA 91626-13 F 175 PPM NORMAL 1 11/23/13 9:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91626-13 F 175 PPM DISPOSITION 4 11/26/13 9:56 P SCHEDULED EUTHANASIA 91626-14 F 175 PPM NORMAL 1 11/23/13 9:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91626-14 F 175 PPM DISPOSITION 4 11/26/13 9:56 P SCHEDULED EUTHANASIA

91643-01 M 175 PPM DISPOSITION 1 11/26/13 9:59 P FOUND DEAD 91643-01 M 175 PPM BODY/INTEGUMENT 1 11/26/13 7:57 P SUBCUTANEOUS HEMORRHAGE FACIAL AREA 91643-02 M 175 PPM NORMAL 1 11/26/13 9:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/29/13 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91643-02 M 175 PPM DISPOSITION 4 11/29/13 7:52 P SCHEDULED EUTHANASIA 91643-03 M 175 PPM NORMAL 1 11/26/13 9:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/29/13 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91643-03 M 175 PPM DISPOSITION 4 11/29/13 7:52 P SCHEDULED EUTHANASIA 91643-04 M 175 PPM NORMAL 1 11/26/13 9:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/29/13 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 990 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 53 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91643-04 M 175 PPM DISPOSITION 4 11/29/13 7:52 P SCHEDULED EUTHANASIA 91643-05 M 175 PPM NORMAL 1 11/26/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/29/13 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91643-05 M 175 PPM DISPOSITION 4 11/29/13 7:52 P SCHEDULED EUTHANASIA 91643-06 M 175 PPM NORMAL 1 11/26/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/29/13 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91643-06 M 175 PPM DISPOSITION 4 11/29/13 7:52 P SCHEDULED EUTHANASIA 91643-07 M 175 PPM NORMAL 1 11/26/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/29/13 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91643-07 M 175 PPM DISPOSITION 4 11/29/13 7:52 P SCHEDULED EUTHANASIA 91643-08 M 175 PPM NORMAL 1 11/26/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/29/13 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91643-08 M 175 PPM DISPOSITION 4 11/29/13 7:53 P SCHEDULED EUTHANASIA 91643-09 M 175 PPM NORMAL 1 11/26/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/29/13 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91643-09 M 175 PPM DISPOSITION 4 11/29/13 7:53 P SCHEDULED EUTHANASIA 91643-10 F 175 PPM NORMAL 1 11/26/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/29/13 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91643-10 F 175 PPM DISPOSITION 4 11/29/13 7:53 P SCHEDULED EUTHANASIA 91643-11 F 175 PPM NORMAL 1 11/26/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/29/13 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91643-11 F 175 PPM DISPOSITION 4 11/29/13 7:53 P SCHEDULED EUTHANASIA 91643-12 F 175 PPM NORMAL 1 11/26/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/29/13 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91643-12 F 175 PPM DISPOSITION 4 11/29/13 7:53 P SCHEDULED EUTHANASIA

91654-01 F 175 PPM DISPOSITION 0 11/25/13 13:44 P FOUND DEAD 91654-02 M 175 PPM DISPOSITION 0 11/25/13 13:44 P FOUND DEAD 91654-03 M 175 PPM DISPOSITION 1 11/26/13 10:04 P FOUND DEAD 91654-04 M 175 PPM NORMAL 1 11/26/13 10:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 991 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 54 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91654-04 M 175 PPM DISPOSITION 2 11/27/13 8:13 P FOUND DEAD 91654-05 M 175 PPM NORMAL 1 11/26/13 10:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91654-05 M 175 PPM DISPOSITION 2 11/27/13 8:13 P FOUND DEAD 91654-06 M 175 PPM NORMAL 1 11/26/13 10:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91654-06 M 175 PPM DISPOSITION 2 11/27/13 8:14 P MISSING 91654-07 M 175 PPM NORMAL 1 11/26/13 10:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91654-07 M 175 PPM DISPOSITION 2 11/27/13 8:13 P FOUND DEAD 91654-08 M 175 PPM NORMAL 1 11/26/13 10:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91654-08 M 175 PPM DISPOSITION 2 11/27/13 8:13 P FOUND DEAD 91654-09 M 175 PPM DISPOSITION 2 11/27/13 8:13 P FOUND DEAD 91654-09 M 175 PPM BODY/INTEGUMENT 1 11/26/13 10:05 P SUBCUTANEOUS HEMORRHAGE FACIAL AREA 91654-10 M 175 PPM DISPOSITION 1 11/26/13 10:04 P FOUND DEAD 91654-11 M 175 PPM NORMAL 1 11/26/13 10:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91654-11 M 175 PPM DISPOSITION 2 11/27/13 8:14 P MISSING 91654-12 M 175 PPM DISPOSITION 2 11/27/13 8:13 P FOUND DEAD 91654-12 M 175 PPM BODY/INTEGUMENT 1 11/26/13 10:05 P SUBCUTANEOUS HEMORRHAGE FACIAL AREA 91654-13 M 175 PPM NORMAL 1 11/26/13 10:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91654-13 M 175 PPM DISPOSITION 2 11/27/13 8:14 P MISSING 91654-14 F 175 PPM DISPOSITION 2 11/27/13 8:13 P FOUND DEAD 91654-14 F 175 PPM BODY/INTEGUMENT 1 11/26/13 10:07 P CYANOTIC 91654-15 F 175 PPM DISPOSITION 2 11/27/13 8:14 P MISSING 91654-15 F 175 PPM BODY/INTEGUMENT 1 11/26/13 10:07 P CYANOTIC 91654-16 F 175 PPM NORMAL 1 11/26/13 10:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91654-16 F 175 PPM DISPOSITION 2 11/27/13 8:14 P MISSING 91654-17 F 175 PPM NORMAL 1 11/26/13 10:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91654-17 F 175 PPM DISPOSITION 2 11/27/13 8:14 P FOUND DEAD 91654-18 F 175 PPM NORMAL 1 11/26/13 10:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91654-18 F 175 PPM DISPOSITION 2 11/27/13 8:14 P MISSING

91657-01 F 175 PPM DISPOSITION 2 12/02/13 7:24 P FOUND DEAD

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 992 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 55 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91657-01 F 175 PPM BODY/INTEGUMENT 1 12/01/13 6:32 P TAIL MISSING 1 12/01/13 6:34 P TAIL MISSING 91657-02 M 175 PPM NORMAL 1 12/01/13 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91657-02 M 175 PPM DISPOSITION 2 12/02/13 7:23 P FOUND DEAD 91657-03 M 175 PPM NORMAL 1 12/01/13 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91657-03 M 175 PPM DISPOSITION 2 12/02/13 7:24 P FOUND DEAD 91657-04 M 175 PPM NORMAL 1 12/01/13 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 12/04/13 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91657-04 M 175 PPM DISPOSITION 4 12/04/13 10:27 P SCHEDULED EUTHANASIA 91657-05 M 175 PPM NORMAL 1 12/01/13 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 12/04/13 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91657-05 M 175 PPM DISPOSITION 4 12/04/13 10:27 P SCHEDULED EUTHANASIA 91657-06 M 175 PPM NORMAL 1 12/01/13 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 12/04/13 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91657-06 M 175 PPM DISPOSITION 4 12/04/13 10:27 P SCHEDULED EUTHANASIA 91657-07 M 175 PPM NORMAL 1 12/01/13 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91657-07 M 175 PPM DISPOSITION 2 12/02/13 7:23 P FOUND DEAD 91657-08 F 175 PPM NORMAL 1 12/01/13 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91657-08 F 175 PPM DISPOSITION 2 12/02/13 7:24 P FOUND DEAD 91657-09 F 175 PPM NORMAL 1 12/01/13 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 12/04/13 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91657-09 F 175 PPM DISPOSITION 4 12/04/13 10:27 P SCHEDULED EUTHANASIA 91657-10 F 175 PPM NORMAL 1 12/01/13 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 12/04/13 7:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91657-10 F 175 PPM DISPOSITION 4 12/04/13 10:27 P SCHEDULED EUTHANASIA 91657-11 F 175 PPM NORMAL 1 12/01/13 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 12/04/13 7:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91657-11 F 175 PPM DISPOSITION 4 12/04/13 10:27 P SCHEDULED EUTHANASIA 91657-12 F 175 PPM NORMAL 1 12/01/13 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 12/04/13 7:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 993 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 56 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91657-12 F 175 PPM DISPOSITION 4 12/04/13 10:27 P SCHEDULED EUTHANASIA 91657-13 F 175 PPM NORMAL 1 12/01/13 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 12/04/13 7:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91657-13 F 175 PPM DISPOSITION 4 12/04/13 10:27 P SCHEDULED EUTHANASIA

91662-01 M 175 PPM DISPOSITION 0 11/22/13 9:35 P FOUND DEAD 91662-02 F 175 PPM DISPOSITION 0 11/22/13 9:36 P FOUND DEAD-A 91662-03 M 175 PPM NORMAL 1 11/23/13 9:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91662-03 M 175 PPM DISPOSITION 4 11/26/13 10:10 P SCHEDULED EUTHANASIA 91662-04 M 175 PPM NORMAL 1 11/23/13 9:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91662-04 M 175 PPM DISPOSITION 4 11/26/13 10:10 P SCHEDULED EUTHANASIA 91662-05 M 175 PPM NORMAL 1 11/23/13 9:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91662-05 M 175 PPM DISPOSITION 4 11/26/13 10:10 P SCHEDULED EUTHANASIA 91662-06 M 175 PPM NORMAL 1 11/23/13 9:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91662-06 M 175 PPM DISPOSITION 4 11/26/13 10:10 P SCHEDULED EUTHANASIA 91662-07 F 175 PPM NORMAL 1 11/23/13 9:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91662-07 F 175 PPM DISPOSITION 2 11/24/13 10:27 P MISSING 91662-08 F 175 PPM NORMAL 1 11/23/13 9:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91662-08 F 175 PPM DISPOSITION 3 11/25/13 10:18 P MISSING 91662-09 F 175 PPM NORMAL 1 11/23/13 9:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91662-09 F 175 PPM DISPOSITION 4 11/26/13 10:11 P SCHEDULED EUTHANASIA 91662-10 F 175 PPM NORMAL 1 11/23/13 9:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91662-10 F 175 PPM DISPOSITION 4 11/26/13 10:11 P SCHEDULED EUTHANASIA 91662-11 F 175 PPM NORMAL 1 11/23/13 9:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY A = PUP FOUND DEAD ON PND 0, BUT HAD MILK IN STOMACH; PUP CONSIDERED BORN ALIVE.**Page 994 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 57 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91662-11 F 175 PPM NORMAL 4 11/26/13 9:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91662-11 F 175 PPM DISPOSITION 4 11/26/13 10:11 P SCHEDULED EUTHANASIA

91666-01 F 175 PPM DISPOSITION 1 11/21/13 11:42 P FOUND DEAD 91666-01 F 175 PPM BODY/INTEGUMENT 0 11/20/13 8:42 P CYANOTIC 0 11/20/13 8:43 P SUBCUTANEOUS HEMORRHAGE DORSAL HEAD 91666-01 F 175 PPM CARDIO-PULMONARY 0 11/20/13 8:43 P GASPING 91666-02 M 175 PPM NORMAL 1 11/21/13 11:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 9:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91666-02 M 175 PPM DISPOSITION 4 11/24/13 10:28 P SCHEDULED EUTHANASIA 91666-03 M 175 PPM NORMAL 1 11/21/13 11:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 9:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91666-03 M 175 PPM DISPOSITION 4 11/24/13 10:28 P SCHEDULED EUTHANASIA 91666-04 M 175 PPM NORMAL 1 11/21/13 11:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 9:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91666-04 M 175 PPM DISPOSITION 4 11/24/13 10:28 P SCHEDULED EUTHANASIA 91666-05 M 175 PPM NORMAL 1 11/21/13 11:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 9:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91666-05 M 175 PPM DISPOSITION 4 11/24/13 10:28 P SCHEDULED EUTHANASIA 91666-06 M 175 PPM NORMAL 1 11/21/13 11:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 9:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91666-06 M 175 PPM DISPOSITION 4 11/24/13 10:28 P SCHEDULED EUTHANASIA 91666-07 M 175 PPM NORMAL 1 11/21/13 11:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 9:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91666-07 M 175 PPM DISPOSITION 4 11/24/13 10:28 P SCHEDULED EUTHANASIA 91666-08 M 175 PPM NORMAL 1 11/21/13 11:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 9:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91666-08 M 175 PPM DISPOSITION 4 11/24/13 10:28 P SCHEDULED EUTHANASIA 91666-09 F 175 PPM NORMAL 1 11/21/13 11:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 9:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 995 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 58 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91666-09 F 175 PPM DISPOSITION 4 11/24/13 10:28 P SCHEDULED EUTHANASIA 91666-10 F 175 PPM NORMAL 1 11/21/13 11:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 9:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91666-10 F 175 PPM DISPOSITION 4 11/24/13 10:28 P SCHEDULED EUTHANASIA 91666-11 F 175 PPM NORMAL 1 11/21/13 11:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 9:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91666-11 F 175 PPM DISPOSITION 4 11/24/13 10:28 P SCHEDULED EUTHANASIA

91676-01 M 175 PPM NORMAL 1 11/22/13 13:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91676-01 M 175 PPM DISPOSITION 4 11/25/13 10:18 P SCHEDULED EUTHANASIA 91676-02 M 175 PPM NORMAL 1 11/22/13 13:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91676-02 M 175 PPM DISPOSITION 4 11/25/13 10:18 P SCHEDULED EUTHANASIA 91676-03 M 175 PPM NORMAL 1 11/22/13 13:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91676-03 M 175 PPM DISPOSITION 4 11/25/13 10:18 P SCHEDULED EUTHANASIA 91676-04 M 175 PPM NORMAL 1 11/22/13 13:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91676-04 M 175 PPM DISPOSITION 4 11/25/13 10:18 P SCHEDULED EUTHANASIA 91676-05 M 175 PPM NORMAL 1 11/22/13 13:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91676-05 M 175 PPM DISPOSITION 4 11/25/13 10:18 P SCHEDULED EUTHANASIA 91676-06 F 175 PPM NORMAL 1 11/22/13 13:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91676-06 F 175 PPM DISPOSITION 4 11/25/13 10:18 P SCHEDULED EUTHANASIA 91676-07 F 175 PPM NORMAL 1 11/22/13 13:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91676-07 F 175 PPM DISPOSITION 4 11/25/13 10:18 P SCHEDULED EUTHANASIA 91676-08 F 175 PPM NORMAL 1 11/22/13 13:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 996 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 59 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91676-08 F 175 PPM NORMAL 4 11/25/13 8:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91676-08 F 175 PPM DISPOSITION 4 11/25/13 10:19 P SCHEDULED EUTHANASIA 91676-09 F 175 PPM NORMAL 1 11/22/13 13:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91676-09 F 175 PPM DISPOSITION 4 11/25/13 10:19 P SCHEDULED EUTHANASIA 91676-10 F 175 PPM DISPOSITION 1 11/22/13 13:25 P MISSING 91676-11 F 175 PPM NORMAL 1 11/22/13 13:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91676-11 F 175 PPM DISPOSITION 4 11/25/13 10:19 P SCHEDULED EUTHANASIA

91678-01 M 175 PPM NORMAL 1 11/21/13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91678-01 M 175 PPM DISPOSITION 4 11/24/13 10:29 P SCHEDULED EUTHANASIA 91678-01 M 175 PPM BODY/INTEGUMENT 0 11/20/13 8:52 P SUBCUTANEOUS HEMORRHAGE FACIAL AREA 91678-02 M 175 PPM NORMAL 1 11/21/13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91678-02 M 175 PPM DISPOSITION 4 11/24/13 10:29 P SCHEDULED EUTHANASIA 91678-03 M 175 PPM NORMAL 1 11/21/13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91678-03 M 175 PPM DISPOSITION 4 11/24/13 10:29 P SCHEDULED EUTHANASIA 91678-04 M 175 PPM NORMAL 1 11/21/13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91678-04 M 175 PPM DISPOSITION 4 11/24/13 10:29 P SCHEDULED EUTHANASIA 91678-05 F 175 PPM NORMAL 1 11/21/13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91678-05 F 175 PPM DISPOSITION 4 11/24/13 8:41 P FOUND DEAD 91678-06 F 175 PPM NORMAL 1 11/21/13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91678-06 F 175 PPM DISPOSITION 4 11/24/13 10:29 P SCHEDULED EUTHANASIA 91678-07 F 175 PPM NORMAL 1 11/21/13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 997 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 60 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91678-07 F 175 PPM DISPOSITION 4 11/24/13 10:29 P SCHEDULED EUTHANASIA 91678-08 F 175 PPM NORMAL 1 11/21/13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91678-08 F 175 PPM DISPOSITION 4 11/24/13 10:29 P SCHEDULED EUTHANASIA 91678-09 F 175 PPM NORMAL 1 11/21/13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91678-09 F 175 PPM DISPOSITION 4 11/24/13 10:29 P SCHEDULED EUTHANASIA 91678-10 F 175 PPM NORMAL 1 11/21/13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91678-10 F 175 PPM DISPOSITION 4 11/24/13 10:29 P SCHEDULED EUTHANASIA 91678-11 F 175 PPM NORMAL 1 11/21/13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91678-11 F 175 PPM DISPOSITION 4 11/24/13 10:29 P SCHEDULED EUTHANASIA 91678-12 F 175 PPM NORMAL 1 11/21/13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91678-12 F 175 PPM DISPOSITION 4 11/24/13 10:29 P SCHEDULED EUTHANASIA 91678-13 F 175 PPM NORMAL 1 11/21/13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91678-13 F 175 PPM DISPOSITION 4 11/24/13 10:29 P SCHEDULED EUTHANASIA 91678-14 F 175 PPM NORMAL 1 11/21/13 11:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91678-14 F 175 PPM DISPOSITION 4 11/24/13 10:29 P SCHEDULED EUTHANASIA

91681-01 F 175 PPM DISPOSITION 0 11/29/13 7:40 P FOUND DEAD 91681-02 F 175 PPM DISPOSITION 0 11/29/13 7:41 P FOUND DEAD 91681-03 M 175 PPM DISPOSITION 1 11/30/13 6:38 P MISSING 91681-03 M 175 PPM BODY/INTEGUMENT 0 11/29/13 7:41 P CYANOTIC 91681-04 M 175 PPM NORMAL 1 11/30/13 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 12/03/13 7:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91681-04 M 175 PPM DISPOSITION 4 12/03/13 7:15 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 998 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 61 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91681-05 M 175 PPM NORMAL 1 11/30/13 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 12/03/13 7:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91681-05 M 175 PPM DISPOSITION 4 12/03/13 7:15 P SCHEDULED EUTHANASIA 91681-06 M 175 PPM NORMAL 1 11/30/13 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 12/03/13 7:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91681-06 M 175 PPM DISPOSITION 4 12/03/13 7:15 P SCHEDULED EUTHANASIA 91681-07 M 175 PPM NORMAL 1 11/30/13 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91681-07 M 175 PPM DISPOSITION 2 12/01/13 6:39 P MISSING 91681-08 M 175 PPM DISPOSITION 1 11/30/13 6:38 P FOUND DEAD 91681-09 M 175 PPM NORMAL 1 11/30/13 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 12/03/13 7:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91681-09 M 175 PPM DISPOSITION 4 12/03/13 7:15 P SCHEDULED EUTHANASIA 91681-10 M 175 PPM NORMAL 1 11/30/13 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 12/03/13 7:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91681-10 M 175 PPM DISPOSITION 4 12/03/13 7:15 P SCHEDULED EUTHANASIA 91681-11 F 175 PPM NORMAL 1 11/30/13 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91681-11 F 175 PPM DISPOSITION 4 12/03/13 7:15 P SCHEDULED EUTHANASIA 91681-11 F 175 PPM BODY/INTEGUMENT 4 12/03/13 7:13 P SMALL STATURE 91681-12 F 175 PPM NORMAL 1 11/30/13 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 12/03/13 7:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91681-12 F 175 PPM DISPOSITION 4 12/03/13 7:15 P SCHEDULED EUTHANASIA 91681-13 F 175 PPM NORMAL 1 11/30/13 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 12/03/13 7:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91681-13 F 175 PPM DISPOSITION 4 12/03/13 7:15 P SCHEDULED EUTHANASIA 91681-14 F 175 PPM NORMAL 1 11/30/13 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 12/03/13 7:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91681-14 F 175 PPM DISPOSITION 4 12/03/13 7:15 P SCHEDULED EUTHANASIA 91681-15 F 175 PPM NORMAL 1 11/30/13 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 12/03/13 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91681-15 F 175 PPM DISPOSITION 4 12/03/13 7:15 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 999 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 62 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91682-01 M 175 PPM DISPOSITION 0 11/22/13 14:15 P FOUND DEAD 91682-02 F 175 PPM DISPOSITION 3 11/25/13 10:21 P MISSING 91682-02 F 175 PPM BODY/INTEGUMENT 0 11/22/13 14:17 P FILAMENTOUS TAIL 1 11/23/13 7:55 P TAIL MISSING 1 11/23/13 9:39 P TAIL MISSING 91682-03 M 175 PPM DISPOSITION 1 11/23/13 7:55 P MISSING 91682-03 M 175 PPM BODY/INTEGUMENT 0 11/22/13 14:17 P CYANOTIC 91682-04 M 175 PPM NORMAL 1 11/23/13 9:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91682-04 M 175 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA 91682-05 M 175 PPM NORMAL 1 11/23/13 9:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91682-05 M 175 PPM DISPOSITION 2 11/24/13 10:32 P MISSING 91682-06 M 175 PPM NORMAL 1 11/23/13 9:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91682-06 M 175 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA 91682-07 M 175 PPM NORMAL 1 11/23/13 9:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91682-07 M 175 PPM DISPOSITION 2 11/24/13 10:32 P MISSING 91682-08 M 175 PPM NORMAL 1 11/23/13 9:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91682-08 M 175 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA 91682-09 M 175 PPM NORMAL 1 11/23/13 9:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91682-09 M 175 PPM DISPOSITION 3 11/25/13 10:22 P MISSING 91682-10 M 175 PPM NORMAL 1 11/23/13 9:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91682-10 M 175 PPM DISPOSITION 2 11/24/13 10:32 P MISSING 91682-11 M 175 PPM NORMAL 1 11/23/13 9:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91682-11 M 175 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA 91682-12 F 175 PPM NORMAL 1 11/23/13 9:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91682-12 F 175 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 1000 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 63 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91682-13 F 175 PPM NORMAL 1 11/23/13 9:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91682-13 F 175 PPM DISPOSITION 2 11/24/13 10:32 P MISSING

91624-01 M 10000 PPM NORMAL 1 11/22/13 13:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91624-01 M 10000 PPM DISPOSITION 4 11/25/13 10:22 P SCHEDULED EUTHANASIA 91624-02 M 10000 PPM NORMAL 1 11/22/13 13:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91624-02 M 10000 PPM DISPOSITION 4 11/25/13 10:22 P SCHEDULED EUTHANASIA 91624-03 M 10000 PPM NORMAL 1 11/22/13 13:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91624-03 M 10000 PPM DISPOSITION 4 11/25/13 10:22 P SCHEDULED EUTHANASIA 91624-04 M 10000 PPM NORMAL 1 11/22/13 13:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91624-04 M 10000 PPM DISPOSITION 4 11/25/13 10:22 P SCHEDULED EUTHANASIA 91624-05 M 10000 PPM NORMAL 1 11/22/13 13:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91624-05 M 10000 PPM DISPOSITION 4 11/25/13 10:22 P SCHEDULED EUTHANASIA 91624-06 M 10000 PPM NORMAL 1 11/22/13 13:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91624-06 M 10000 PPM DISPOSITION 4 11/25/13 10:22 P SCHEDULED EUTHANASIA 91624-07 M 10000 PPM NORMAL 1 11/22/13 13:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91624-07 M 10000 PPM DISPOSITION 4 11/25/13 10:22 P SCHEDULED EUTHANASIA 91624-08 M 10000 PPM NORMAL 1 11/22/13 13:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91624-08 M 10000 PPM DISPOSITION 4 11/25/13 10:22 P SCHEDULED EUTHANASIA 91624-09 F 10000 PPM NORMAL 1 11/22/13 13:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91624-09 F 10000 PPM DISPOSITION 4 11/25/13 10:22 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 1001 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 64 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91624-10 F 10000 PPM NORMAL 1 11/22/13 13:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91624-10 F 10000 PPM DISPOSITION 4 11/25/13 10:22 P SCHEDULED EUTHANASIA 91624-11 F 10000 PPM NORMAL 1 11/22/13 13:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91624-11 F 10000 PPM DISPOSITION 4 11/25/13 10:22 P SCHEDULED EUTHANASIA 91624-12 F 10000 PPM NORMAL 1 11/22/13 13:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91624-12 F 10000 PPM DISPOSITION 4 11/25/13 10:23 P SCHEDULED EUTHANASIA 91624-13 F 10000 PPM NORMAL 1 11/22/13 13:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91624-13 F 10000 PPM DISPOSITION 4 11/25/13 10:23 P SCHEDULED EUTHANASIA

91625-01 M 10000 PPM NORMAL 1 11/23/13 9:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91625-01 M 10000 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA 91625-02 M 10000 PPM NORMAL 1 11/23/13 9:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91625-02 M 10000 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA 91625-03 M 10000 PPM NORMAL 1 11/23/13 9:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91625-03 M 10000 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA 91625-04 M 10000 PPM NORMAL 1 11/23/13 9:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91625-04 M 10000 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA 91625-05 M 10000 PPM NORMAL 1 11/23/13 9:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91625-05 M 10000 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA 91625-06 F 10000 PPM NORMAL 1 11/23/13 9:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 1002 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 65 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91625-06 F 10000 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA 91625-07 F 10000 PPM NORMAL 1 11/23/13 9:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91625-07 F 10000 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA 91625-08 F 10000 PPM NORMAL 1 11/23/13 9:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91625-08 F 10000 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA 91625-09 F 10000 PPM NORMAL 1 11/23/13 9:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91625-09 F 10000 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA 91625-10 F 10000 PPM NORMAL 1 11/23/13 9:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91625-10 F 10000 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA 91625-11 F 10000 PPM NORMAL 1 11/23/13 9:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91625-11 F 10000 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA 91625-12 F 10000 PPM NORMAL 1 11/23/13 9:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91625-12 F 10000 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA 91625-13 F 10000 PPM NORMAL 1 11/23/13 9:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91625-13 F 10000 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA 91625-14 F 10000 PPM NORMAL 1 11/23/13 9:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91625-14 F 10000 PPM DISPOSITION 4 11/26/13 10:13 P SCHEDULED EUTHANASIA

91627-01 M 10000 PPM NORMAL 1 11/20/13 12:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91627-01 M 10000 PPM DISPOSITION 4 11/23/13 12:42 P SCHEDULED EUTHANASIA 91627-02 M 10000 PPM NORMAL 1 11/20/13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 1003 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 66 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91627-02 M 10000 PPM NORMAL 4 11/23/13 9:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91627-02 M 10000 PPM DISPOSITION 4 11/23/13 12:42 P SCHEDULED EUTHANASIA 91627-03 M 10000 PPM NORMAL 1 11/20/13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91627-03 M 10000 PPM DISPOSITION 4 11/23/13 12:42 P SCHEDULED EUTHANASIA 91627-04 M 10000 PPM NORMAL 1 11/20/13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91627-04 M 10000 PPM DISPOSITION 4 11/23/13 12:42 P SCHEDULED EUTHANASIA 91627-05 M 10000 PPM NORMAL 1 11/20/13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91627-05 M 10000 PPM DISPOSITION 4 11/23/13 12:42 P SCHEDULED EUTHANASIA 91627-06 M 10000 PPM NORMAL 1 11/20/13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91627-06 M 10000 PPM DISPOSITION 4 11/23/13 12:42 P SCHEDULED EUTHANASIA 91627-07 M 10000 PPM NORMAL 1 11/20/13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91627-07 M 10000 PPM DISPOSITION 4 11/23/13 12:42 P SCHEDULED EUTHANASIA 91627-08 M 10000 PPM NORMAL 1 11/20/13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91627-08 M 10000 PPM DISPOSITION 4 11/23/13 12:42 P SCHEDULED EUTHANASIA 91627-09 F 10000 PPM NORMAL 1 11/20/13 12:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91627-09 F 10000 PPM DISPOSITION 4 11/23/13 12:42 P SCHEDULED EUTHANASIA 91627-10 F 10000 PPM NORMAL 1 11/20/13 12:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91627-10 F 10000 PPM DISPOSITION 4 11/23/13 12:42 P SCHEDULED EUTHANASIA 91627-11 F 10000 PPM NORMAL 1 11/20/13 12:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91627-11 F 10000 PPM DISPOSITION 4 11/23/13 12:42 P SCHEDULED EUTHANASIA 91627-12 F 10000 PPM NORMAL 1 11/20/13 12:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 1004 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 67 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91627-12 F 10000 PPM NORMAL 4 11/23/13 9:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91627-12 F 10000 PPM DISPOSITION 4 11/23/13 12:42 P SCHEDULED EUTHANASIA 91627-13 F 10000 PPM NORMAL 1 11/20/13 12:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91627-13 F 10000 PPM DISPOSITION 4 11/23/13 12:42 P SCHEDULED EUTHANASIA

91634-01 M 10000 PPM NORMAL 1 11/23/13 9:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91634-01 M 10000 PPM DISPOSITION 4 11/26/13 10:13 P SCHEDULED EUTHANASIA 91634-02 M 10000 PPM NORMAL 1 11/23/13 9:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91634-02 M 10000 PPM DISPOSITION 4 11/26/13 10:13 P SCHEDULED EUTHANASIA 91634-03 M 10000 PPM NORMAL 1 11/23/13 9:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91634-03 M 10000 PPM DISPOSITION 4 11/26/13 10:13 P SCHEDULED EUTHANASIA 91634-04 M 10000 PPM NORMAL 1 11/23/13 9:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91634-04 M 10000 PPM DISPOSITION 4 11/26/13 10:13 P SCHEDULED EUTHANASIA 91634-05 M 10000 PPM NORMAL 1 11/23/13 9:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91634-05 M 10000 PPM DISPOSITION 4 11/26/13 10:13 P SCHEDULED EUTHANASIA 91634-06 M 10000 PPM NORMAL 1 11/23/13 9:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91634-06 M 10000 PPM DISPOSITION 4 11/26/13 10:13 P SCHEDULED EUTHANASIA 91634-07 F 10000 PPM NORMAL 1 11/23/13 9:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91634-07 F 10000 PPM DISPOSITION 4 11/26/13 10:13 P SCHEDULED EUTHANASIA 91634-08 F 10000 PPM NORMAL 1 11/23/13 9:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91634-08 F 10000 PPM DISPOSITION 4 11/26/13 10:13 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 1005 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 68 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91634-09 F 10000 PPM NORMAL 1 11/23/13 9:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91634-09 F 10000 PPM DISPOSITION 4 11/26/13 10:13 P SCHEDULED EUTHANASIA 91634-10 F 10000 PPM NORMAL 1 11/23/13 9:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91634-10 F 10000 PPM DISPOSITION 4 11/26/13 10:13 P SCHEDULED EUTHANASIA 91634-11 F 10000 PPM NORMAL 1 11/23/13 9:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91634-11 F 10000 PPM DISPOSITION 4 11/26/13 10:13 P SCHEDULED EUTHANASIA 91634-12 F 10000 PPM NORMAL 1 11/23/13 9:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91634-12 F 10000 PPM DISPOSITION 4 11/26/13 10:13 P SCHEDULED EUTHANASIA 91634-13 F 10000 PPM NORMAL 1 11/23/13 9:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/26/13 9:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91634-13 F 10000 PPM DISPOSITION 4 11/26/13 10:13 P SCHEDULED EUTHANASIA

91635-01 M 10000 PPM DISPOSITION 0 11/19/13 14:03 P FOUND DEAD 91635-02 M 10000 PPM NORMAL 1 11/20/13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91635-02 M 10000 PPM DISPOSITION 4 11/23/13 13:23 P SCHEDULED EUTHANASIA 91635-03 M 10000 PPM NORMAL 1 11/20/13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91635-03 M 10000 PPM DISPOSITION 4 11/23/13 13:23 P SCHEDULED EUTHANASIA 91635-04 M 10000 PPM NORMAL 1 11/20/13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91635-04 M 10000 PPM DISPOSITION 4 11/23/13 13:23 P SCHEDULED EUTHANASIA 91635-05 M 10000 PPM NORMAL 1 11/20/13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91635-05 M 10000 PPM DISPOSITION 4 11/23/13 13:23 P SCHEDULED EUTHANASIA 91635-06 M 10000 PPM NORMAL 1 11/20/13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 1006 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 69 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91635-06 M 10000 PPM NORMAL 4 11/23/13 9:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91635-06 M 10000 PPM DISPOSITION 4 11/23/13 13:23 P SCHEDULED EUTHANASIA 91635-07 M 10000 PPM NORMAL 1 11/20/13 12:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91635-07 M 10000 PPM DISPOSITION 4 11/23/13 13:23 P SCHEDULED EUTHANASIA 91635-08 F 10000 PPM NORMAL 1 11/20/13 12:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91635-08 F 10000 PPM DISPOSITION 4 11/23/13 13:23 P SCHEDULED EUTHANASIA 91635-09 F 10000 PPM NORMAL 1 11/20/13 12:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91635-09 F 10000 PPM DISPOSITION 4 11/23/13 13:23 P SCHEDULED EUTHANASIA 91635-10 F 10000 PPM NORMAL 1 11/20/13 12:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91635-10 F 10000 PPM DISPOSITION 4 11/23/13 13:23 P SCHEDULED EUTHANASIA 91635-11 F 10000 PPM NORMAL 1 11/20/13 12:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91635-11 F 10000 PPM DISPOSITION 4 11/23/13 13:23 P SCHEDULED EUTHANASIA 91635-12 F 10000 PPM NORMAL 1 11/20/13 12:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91635-12 F 10000 PPM DISPOSITION 4 11/23/13 13:23 P SCHEDULED EUTHANASIA 91635-13 F 10000 PPM NORMAL 1 11/20/13 12:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91635-13 F 10000 PPM DISPOSITION 4 11/23/13 13:23 P SCHEDULED EUTHANASIA

91638-01 M 10000 PPM NORMAL 1 11/22/13 13:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91638-01 M 10000 PPM DISPOSITION 4 11/25/13 10:24 P SCHEDULED EUTHANASIA 91638-02 M 10000 PPM NORMAL 1 11/22/13 13:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91638-02 M 10000 PPM DISPOSITION 4 11/25/13 10:24 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 1007 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 70 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91638-03 M 10000 PPM NORMAL 1 11/22/13 13:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91638-03 M 10000 PPM DISPOSITION 4 11/25/13 10:24 P SCHEDULED EUTHANASIA 91638-04 M 10000 PPM NORMAL 1 11/22/13 13:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91638-04 M 10000 PPM DISPOSITION 4 11/25/13 10:24 P SCHEDULED EUTHANASIA 91638-05 M 10000 PPM NORMAL 1 11/22/13 13:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91638-05 M 10000 PPM DISPOSITION 4 11/25/13 10:24 P SCHEDULED EUTHANASIA 91638-06 M 10000 PPM NORMAL 1 11/22/13 13:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91638-06 M 10000 PPM DISPOSITION 4 11/25/13 10:24 P SCHEDULED EUTHANASIA 91638-07 M 10000 PPM NORMAL 1 11/22/13 13:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91638-07 M 10000 PPM DISPOSITION 4 11/25/13 10:24 P SCHEDULED EUTHANASIA 91638-08 M 10000 PPM NORMAL 1 11/22/13 13:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91638-08 M 10000 PPM DISPOSITION 4 11/25/13 10:24 P SCHEDULED EUTHANASIA 91638-09 M 10000 PPM NORMAL 1 11/22/13 13:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91638-09 M 10000 PPM DISPOSITION 4 11/25/13 10:24 P SCHEDULED EUTHANASIA 91638-10 F 10000 PPM NORMAL 1 11/22/13 13:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91638-10 F 10000 PPM DISPOSITION 4 11/25/13 10:24 P SCHEDULED EUTHANASIA 91638-11 F 10000 PPM NORMAL 1 11/22/13 13:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91638-11 F 10000 PPM DISPOSITION 4 11/25/13 10:24 P SCHEDULED EUTHANASIA 91638-12 F 10000 PPM NORMAL 1 11/22/13 13:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91638-12 F 10000 PPM DISPOSITION 4 11/25/13 10:25 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 1008 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 71 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91638-13 F 10000 PPM NORMAL 1 11/22/13 13:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91638-13 F 10000 PPM DISPOSITION 4 11/25/13 10:25 P SCHEDULED EUTHANASIA 91638-14 F 10000 PPM NORMAL 4 11/25/13 8:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91638-14 F 10000 PPM DISPOSITION 4 11/25/13 10:25 P SCHEDULED EUTHANASIA 91638-14 F 10000 PPM BODY/INTEGUMENT 1 11/22/13 13:32 P SUBCUTANEOUS HEMORRHAGE FACIAL AREA 91638-15 F 10000 PPM NORMAL 1 11/22/13 13:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91638-15 F 10000 PPM DISPOSITION 4 11/25/13 10:25 P SCHEDULED EUTHANASIA 91638-16 F 10000 PPM NORMAL 1 11/22/13 13:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/25/13 8:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91638-16 F 10000 PPM DISPOSITION 4 11/25/13 10:25 P SCHEDULED EUTHANASIA

91652-01 M 10000 PPM DISPOSITION 0 11/19/13 14:15 P FOUND DEAD 91652-02 U 10000 PPM DISPOSITION 0 11/19/13 14:15 P FOUND DEAD; PARTIALLY CANNIBALIZED 91652-03 M 10000 PPM NORMAL 1 11/20/13 12:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91652-03 M 10000 PPM DISPOSITION 4 11/23/13 13:24 P SCHEDULED EUTHANASIA 91652-04 M 10000 PPM NORMAL 1 11/20/13 12:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91652-04 M 10000 PPM DISPOSITION 4 11/23/13 13:24 P SCHEDULED EUTHANASIA 91652-05 M 10000 PPM NORMAL 1 11/20/13 12:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91652-05 M 10000 PPM DISPOSITION 4 11/23/13 13:24 P SCHEDULED EUTHANASIA 91652-06 M 10000 PPM NORMAL 1 11/20/13 12:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91652-06 M 10000 PPM DISPOSITION 4 11/23/13 13:24 P SCHEDULED EUTHANASIA 91652-07 M 10000 PPM NORMAL 1 11/20/13 12:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91652-07 M 10000 PPM DISPOSITION 4 11/23/13 13:24 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 1009 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 72 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91652-08 M 10000 PPM NORMAL 1 11/20/13 12:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91652-08 M 10000 PPM DISPOSITION 4 11/23/13 13:24 P SCHEDULED EUTHANASIA 91652-09 M 10000 PPM NORMAL 1 11/20/13 12:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91652-09 M 10000 PPM DISPOSITION 4 11/23/13 13:24 P SCHEDULED EUTHANASIA 91652-10 M 10000 PPM NORMAL 1 11/20/13 12:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91652-10 M 10000 PPM DISPOSITION 4 11/23/13 13:24 P SCHEDULED EUTHANASIA 91652-11 F 10000 PPM NORMAL 1 11/20/13 12:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91652-11 F 10000 PPM DISPOSITION 4 11/23/13 13:24 P SCHEDULED EUTHANASIA 91652-11 F 10000 PPM BODY/INTEGUMENT 4 11/23/13 9:55 P SMALL STATURE 91652-12 F 10000 PPM NORMAL 1 11/20/13 12:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91652-12 F 10000 PPM DISPOSITION 4 11/23/13 13:24 P SCHEDULED EUTHANASIA 91652-13 F 10000 PPM NORMAL 1 11/20/13 12:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91652-13 F 10000 PPM DISPOSITION 4 11/23/13 13:24 P SCHEDULED EUTHANASIA

91655-01 M 10000 PPM NORMAL 1 11/20/13 12:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91655-01 M 10000 PPM DISPOSITION 4 11/23/13 13:25 P SCHEDULED EUTHANASIA 91655-02 M 10000 PPM NORMAL 1 11/20/13 12:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91655-02 M 10000 PPM DISPOSITION 4 11/23/13 13:25 P SCHEDULED EUTHANASIA 91655-03 M 10000 PPM NORMAL 1 11/20/13 12:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91655-03 M 10000 PPM DISPOSITION 4 11/23/13 13:25 P SCHEDULED EUTHANASIA 91655-04 M 10000 PPM NORMAL 1 11/20/13 12:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 1010 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 73 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91655-04 M 10000 PPM DISPOSITION 4 11/23/13 13:25 P SCHEDULED EUTHANASIA 91655-05 F 10000 PPM NORMAL 1 11/20/13 12:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91655-05 F 10000 PPM DISPOSITION 4 11/23/13 13:25 P SCHEDULED EUTHANASIA 91655-06 F 10000 PPM NORMAL 1 11/20/13 12:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91655-06 F 10000 PPM DISPOSITION 4 11/23/13 13:25 P SCHEDULED EUTHANASIA 91655-07 F 10000 PPM NORMAL 1 11/20/13 12:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91655-07 F 10000 PPM DISPOSITION 4 11/23/13 13:25 P SCHEDULED EUTHANASIA 91655-08 F 10000 PPM NORMAL 1 11/20/13 12:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91655-08 F 10000 PPM DISPOSITION 2 11/21/13 11:56 P FOUND DEAD 91655-09 F 10000 PPM NORMAL 1 11/20/13 12:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91655-09 F 10000 PPM DISPOSITION 4 11/23/13 13:25 P SCHEDULED EUTHANASIA 91655-10 F 10000 PPM NORMAL 1 11/20/13 12:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91655-10 F 10000 PPM DISPOSITION 4 11/23/13 13:25 P SCHEDULED EUTHANASIA 91655-11 F 10000 PPM NORMAL 1 11/20/13 12:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91655-11 F 10000 PPM DISPOSITION 4 11/23/13 13:25 P SCHEDULED EUTHANASIA 91655-12 F 10000 PPM NORMAL 1 11/20/13 12:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91655-12 F 10000 PPM DISPOSITION 4 11/23/13 13:25 P SCHEDULED EUTHANASIA 91655-13 F 10000 PPM DISPOSITION 1 11/20/13 12:48 P FOUND DEAD

91658-01 M 10000 PPM NORMAL 1 11/21/13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91658-01 M 10000 PPM DISPOSITION 4 11/24/13 10:35 P SCHEDULED EUTHANASIA 91658-02 M 10000 PPM NORMAL 1 11/21/13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 1011 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 74 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91658-02 M 10000 PPM NORMAL 4 11/24/13 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91658-02 M 10000 PPM DISPOSITION 4 11/24/13 10:35 P SCHEDULED EUTHANASIA 91658-03 M 10000 PPM NORMAL 1 11/21/13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91658-03 M 10000 PPM DISPOSITION 4 11/24/13 10:35 P SCHEDULED EUTHANASIA 91658-04 M 10000 PPM NORMAL 1 11/21/13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91658-04 M 10000 PPM DISPOSITION 4 11/24/13 10:35 P SCHEDULED EUTHANASIA 91658-05 M 10000 PPM NORMAL 1 11/21/13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91658-05 M 10000 PPM DISPOSITION 4 11/24/13 10:35 P SCHEDULED EUTHANASIA 91658-06 M 10000 PPM NORMAL 1 11/21/13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91658-06 M 10000 PPM DISPOSITION 4 11/24/13 10:35 P SCHEDULED EUTHANASIA 91658-07 M 10000 PPM NORMAL 1 11/21/13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91658-07 M 10000 PPM DISPOSITION 4 11/24/13 10:35 P SCHEDULED EUTHANASIA 91658-08 M 10000 PPM NORMAL 1 11/21/13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91658-08 M 10000 PPM DISPOSITION 4 11/24/13 10:35 P SCHEDULED EUTHANASIA 91658-09 F 10000 PPM NORMAL 1 11/21/13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91658-09 F 10000 PPM DISPOSITION 4 11/24/13 10:35 P SCHEDULED EUTHANASIA 91658-10 F 10000 PPM NORMAL 1 11/21/13 12:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91658-10 F 10000 PPM DISPOSITION 4 11/24/13 10:35 P SCHEDULED EUTHANASIA 91658-11 F 10000 PPM NORMAL 1 11/21/13 12:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91658-11 F 10000 PPM DISPOSITION 4 11/24/13 10:35 P SCHEDULED EUTHANASIA 91658-12 F 10000 PPM NORMAL 1 11/21/13 12:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 1012 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 75 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91658-12 F 10000 PPM NORMAL 4 11/24/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91658-12 F 10000 PPM DISPOSITION 4 11/24/13 10:35 P SCHEDULED EUTHANASIA 91658-13 F 10000 PPM NORMAL 1 11/21/13 12:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91658-13 F 10000 PPM DISPOSITION 4 11/24/13 10:35 P SCHEDULED EUTHANASIA

91667-01 M 10000 PPM NORMAL 1 11/21/13 12:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91667-01 M 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA 91667-02 M 10000 PPM NORMAL 1 11/21/13 12:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91667-02 M 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA 91667-03 M 10000 PPM NORMAL 1 11/21/13 12:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91667-03 M 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA 91667-04 M 10000 PPM NORMAL 1 11/21/13 12:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91667-04 M 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA 91667-05 M 10000 PPM NORMAL 1 11/21/13 12:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91667-05 M 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA 91667-06 F 10000 PPM NORMAL 1 11/21/13 12:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91667-06 F 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA 91667-07 F 10000 PPM NORMAL 1 11/21/13 12:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91667-07 F 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA 91667-08 F 10000 PPM NORMAL 1 11/21/13 12:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91667-08 F 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 1013 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 76 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91667-09 F 10000 PPM NORMAL 1 11/21/13 12:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91667-09 F 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA 91667-10 F 10000 PPM NORMAL 1 11/21/13 12:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91667-10 F 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA 91667-11 F 10000 PPM NORMAL 1 11/21/13 12:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91667-11 F 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA 91667-12 F 10000 PPM NORMAL 1 11/21/13 12:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91667-12 F 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA 91667-13 F 10000 PPM NORMAL 1 11/21/13 12:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91667-13 F 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA 91667-14 F 10000 PPM NORMAL 1 11/21/13 12:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91667-14 F 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA 91667-15 F 10000 PPM NORMAL 1 11/21/13 12:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91667-15 F 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA 91667-16 F 10000 PPM NORMAL 1 11/21/13 12:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91667-16 F 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA

91668-01 U 10000 PPM DISPOSITION 0 11/20/13 14:25 P FOUND DEAD; PARTIALLY CANNIBALIZED 91668-02 F 10000 PPM DISPOSITION 0 11/20/13 14:25 P FOUND DEAD 91668-03 M 10000 PPM NORMAL 1 11/21/13 12:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91668-03 M 10000 PPM DISPOSITION 4 11/24/13 10:37 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 1014 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 77 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91668-04 M 10000 PPM NORMAL 1 11/21/13 12:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91668-04 M 10000 PPM DISPOSITION 4 11/24/13 10:37 P SCHEDULED EUTHANASIA 91668-05 M 10000 PPM NORMAL 1 11/21/13 12:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91668-05 M 10000 PPM DISPOSITION 4 11/24/13 10:37 P SCHEDULED EUTHANASIA 91668-06 M 10000 PPM NORMAL 1 11/21/13 12:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91668-06 M 10000 PPM DISPOSITION 4 11/24/13 10:37 P SCHEDULED EUTHANASIA 91668-07 M 10000 PPM NORMAL 1 11/21/13 12:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91668-07 M 10000 PPM DISPOSITION 4 11/24/13 10:37 P SCHEDULED EUTHANASIA 91668-08 M 10000 PPM NORMAL 1 11/21/13 12:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91668-08 M 10000 PPM DISPOSITION 4 11/24/13 10:37 P SCHEDULED EUTHANASIA 91668-09 M 10000 PPM NORMAL 1 11/21/13 12:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91668-09 M 10000 PPM DISPOSITION 4 11/24/13 10:37 P SCHEDULED EUTHANASIA 91668-10 M 10000 PPM NORMAL 1 11/21/13 12:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91668-10 M 10000 PPM DISPOSITION 4 11/24/13 10:37 P SCHEDULED EUTHANASIA 91668-11 M 10000 PPM NORMAL 1 11/21/13 12:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91668-11 M 10000 PPM DISPOSITION 4 11/24/13 10:37 P SCHEDULED EUTHANASIA 91668-12 F 10000 PPM NORMAL 1 11/21/13 12:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91668-12 F 10000 PPM DISPOSITION 4 11/24/13 10:37 P SCHEDULED EUTHANASIA 91668-13 F 10000 PPM NORMAL 1 11/21/13 12:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91668-13 F 10000 PPM DISPOSITION 4 11/24/13 10:37 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 1015 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 78 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91668-14 F 10000 PPM NORMAL 1 11/21/13 12:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91668-14 F 10000 PPM DISPOSITION 4 11/24/13 10:37 P SCHEDULED EUTHANASIA 91668-15 F 10000 PPM NORMAL 1 11/21/13 12:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/24/13 8:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91668-15 F 10000 PPM DISPOSITION 4 11/24/13 10:37 P SCHEDULED EUTHANASIA

91680-01 M 10000 PPM NORMAL 1 11/20/13 12:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91680-01 M 10000 PPM DISPOSITION 4 11/23/13 13:26 P SCHEDULED EUTHANASIA 91680-02 M 10000 PPM NORMAL 1 11/20/13 12:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91680-02 M 10000 PPM DISPOSITION 4 11/23/13 13:26 P SCHEDULED EUTHANASIA 91680-03 M 10000 PPM NORMAL 1 11/20/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 9:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91680-03 M 10000 PPM DISPOSITION 4 11/23/13 13:26 P SCHEDULED EUTHANASIA 91680-04 M 10000 PPM NORMAL 1 11/20/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91680-04 M 10000 PPM DISPOSITION 4 11/23/13 13:26 P SCHEDULED EUTHANASIA 91680-05 M 10000 PPM NORMAL 1 11/20/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91680-05 M 10000 PPM DISPOSITION 4 11/23/13 13:26 P SCHEDULED EUTHANASIA 91680-06 M 10000 PPM NORMAL 1 11/20/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91680-06 M 10000 PPM DISPOSITION 4 11/23/13 13:26 P SCHEDULED EUTHANASIA 91680-07 M 10000 PPM NORMAL 1 11/20/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91680-07 M 10000 PPM DISPOSITION 4 11/23/13 13:26 P SCHEDULED EUTHANASIA 91680-08 F 10000 PPM NORMAL 1 11/20/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY**Page 1016 of 1107**TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 79 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

----------------------------------------------------------------------------------------------------------------------------------- 91680-08 F 10000 PPM DISPOSITION 4 11/23/13 13:26 P SCHEDULED EUTHANASIA 91680-09 F 10000 PPM NORMAL 1 11/20/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91680-09 F 10000 PPM DISPOSITION 4 11/23/13 13:26 P SCHEDULED EUTHANASIA 91680-10 F 10000 PPM NORMAL 1 11/20/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91680-10 F 10000 PPM DISPOSITION 4 11/23/13 13:26 P SCHEDULED EUTHANASIA 91680-11 F 10000 PPM NORMAL 1 11/20/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 10:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91680-11 F 10000 PPM DISPOSITION 4 11/23/13 13:26 P SCHEDULED EUTHANASIA 91680-12 F 10000 PPM NORMAL 1 11/20/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 10:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91680-12 F 10000 PPM DISPOSITION 4 11/23/13 13:26 P SCHEDULED EUTHANASIA 91680-13 F 10000 PPM NORMAL 1 11/20/13 12:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 10:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91680-13 F 10000 PPM DISPOSITION 4 11/23/13 13:26 P SCHEDULED EUTHANASIA 91680-14 F 10000 PPM NORMAL 1 11/20/13 12:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 10:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91680-14 F 10000 PPM DISPOSITION 4 11/23/13 13:26 P SCHEDULED EUTHANASIA 91680-15 F 10000 PPM NORMAL 1 11/20/13 12:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 4 11/23/13 10:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 91680-15 F 10000 PPM DISPOSITION 4 11/23/13 13:27 P SCHEDULED EUTHANASIA

----------------------------------------------------------------------------------------------------------------------------------- GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY PPOCRDv1.05 01/07/2014 R:01/20/2014**Page 1017 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91629-01 M 5.9 7.5 91629-02 M 5.5 7.2 91629-03 M 5.5 7.5 91629-04 M 5.3 6.7 91629-05 M 5.4 7.0 91629-06 M 5.9 8.0 91629-07 M 4.2 NA 91629-08 M 4.7 6.1 91629-09 M 5.9 7.7 91629-10 M 5.7 7.4 91629-11 M 5.8 7.5 91629-12 M 5.9 7.8 91629-13 F 5.6 7.4 91629-14 F 5.8 7.7 91629-15 F 5.4 6.7 91629-16 F 5.7 7.6

MALES MEAN 5.5 7.3 FEMALES MEAN 5.6 7.4

91630-03 M 7.0 10.6 91630-04 M 7.0 10.5 91630-05 M 7.2 10.3 91630-06 M 6.8 10.0 91630-07 M 7.2 10.5 91630-08 M 7.0 10.4

NA = NOT APPLICABLE**Page 1018 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91630-09 F 6.6 9.6 91630-10 F 6.3 9.4 91630-11 F 7.0 10.2 91630-12 F 6.4 9.3 91630-13 F 6.9 10.3 91630-14 F 6.8 9.5

MALES MEAN 7.0 10.4 FEMALES MEAN 6.7 9.7

91633-01 M 6.5 8.0 91633-02 M 6.2 8.5 91633-03 M 6.8 8.9 91633-04 M 5.8 7.1 91633-05 M 6.6 8.0 91633-06 M 6.3 8.1 91633-07 M 6.1 7.1 91633-08 F 6.3 8.3 91633-09 F 5.9 6.9 91633-10 F 6.0 8.5 91633-11 F 5.4 7.4 91633-12 F 6.0 8.0 91633-13 F 5.6 6.3 91633-14 F 5.8 7.7**Page 1019 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91633-15 F 5.5 7.1

MALES MEAN 6.3 8.0 FEMALES MEAN 5.8 7.5

91637-01 M 6.4 8.8 91637-02 M 6.6 8.9 91637-03 M 6.6 8.4 91637-04 M 6.4 8.9 91637-05 M 3.2 NA 91637-06 F 5.9 8.7 91637-07 F 6.3 8.7 91637-08 F 6.3 8.7 91637-09 F 6.2 8.9 91637-10 F 6.0 7.7 91637-11 F 5.7 8.5 91637-12 F 5.9 8.5 91637-13 F 5.9 8.4

MALES MEAN 5.8 8.8 FEMALES MEAN 6.0 8.5

91639-02 M 7.6 11.2 91639-03 M 7.7 11.4 91639-04 M 7.6 11.2 91639-05 M 7.3 11.4

NA = NOT APPLICABLE**Page 1020 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91639-06 M 7.1 9.9 91639-07 M 8.6 12.3 91639-08 M 6.9 9.7 91639-09 F 7.3 10.4 91639-10 F 6.9 9.8

MALES MEAN 7.5 11.0 FEMALES MEAN 7.1 10.1

91644-01 M 5.5 7.2 91644-02 M 5.5 7.1 91644-03 M 5.5 7.2 91644-04 M 5.5 6.2 91644-05 M 5.7 7.2 91644-06 M 5.5 6.7 91644-07 M 5.5 7.3 91644-08 M 5.9 7.3 91644-09 M 5.6 6.9 91644-10 M 5.5 6.7 91644-11 F 5.1 6.4 91644-12 F 5.1 6.2 91644-13 F 4.6 5.6 91644-14 F 5.3 6.7 91644-15 F 5.4 6.6 91644-16 F 5.3 6.5**Page 1021 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91644-17 F 5.5 NA

MALES MEAN 5.6 7.0 FEMALES MEAN 5.2 6.3

91645-01 M 6.6 9.5 91645-02 M 6.6 9.4 91645-03 M 6.8 9.8 91645-04 M 6.4 9.6 91645-05 M 7.3 11.1 91645-06 M 6.4 9.3 91645-07 M 6.6 9.7 91645-09 M 6.7 10.3 91645-10 F 6.5 9.7 91645-11 F 6.1 8.3 91645-12 F 5.9 8.9 91645-13 F 6.2 9.3 91645-14 F 6.5 9.6 91645-15 F 6.7 9.6 91645-16 F 7.2 10.7

MALES MEAN 6.7 9.8 FEMALES MEAN 6.4 9.4

91648-02 M 7.7 11.2 91648-03 M 8.9 12.5

NA = NOT APPLICABLE**Page 1022 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91648-04 M 7.7 11.5 91648-05 M 7.7 11.4 91648-06 M 8.0 11.4 91648-07 M 6.9 10.2 91648-08 M 8.0 12.2 91648-09 M 7.7 11.3 91648-10 F 7.8 11.2 91648-11 F 7.8 10.8 91648-12 F 7.6 11.3 91648-13 F 7.0 10.5 91648-14 F 7.5 11.3

MALES MEAN 7.8 11.5 FEMALES MEAN 7.5 11.0

91653-01 M 7.9 9.8 91653-02 M 7.8 10.9 91653-03 M 6.1 7.3 91653-04 M 7.7 10.4 91653-05 M 7.9 10.3 91653-06 M 7.7 9.8 91653-07 F 7.1 9.1 91653-08 F 7.3 9.7 91653-09 F 7.7 10.0 91653-10 F 5.7 7.0 91653-11 F 7.0 9.7**Page 1023 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91653-12 F 7.8 9.6 91653-13 F 7.2 9.2 91653-14 F 7.3 9.7 91653-15 F 7.4 8.8

MALES MEAN 7.5 9.8 FEMALES MEAN 7.2 9.2

91660-02 M 8.4 11.8 91660-03 M 7.7 11.3 91660-04 M 7.3 10.3 91660-05 M 7.9 11.8 91660-06 M 8.6 12.4 91660-07 M 8.3 11.7 91660-08 M 8.3 12.1 91660-09 M 8.4 12.0 91660-10 F 7.6 10.6 91660-11 F 7.3 10.1 91660-12 F 7.6 10.2 91660-13 F 7.9 11.0 91660-14 F 6.7 9.7

MALES MEAN 8.1 11.7 FEMALES MEAN 7.4 10.3

91670-01 M 6.7 8.5**Page 1024 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91670-02 M 7.0 9.1 91670-03 M 6.8 9.1 91670-04 M 7.1 9.3 91670-05 M 7.8 10.5 91670-06 M 7.1 9.4 91670-07 M 5.7 7.9 91670-08 M 7.1 9.2 91670-09 F 6.5 8.8 91670-10 F 6.8 9.6 91670-11 F 6.7 7.9 91670-12 F 6.8 8.8 91670-13 F 7.1 9.7 91670-14 F 7.1 9.0

MALES MEAN 6.9 9.1 FEMALES MEAN 6.8 9.0

91672-02 M 7.2 10.7 91672-03 M 7.4 10.8 91672-04 M 7.0 11.2 91672-05 M 7.8 9.8 91672-06 M 7.4 12.2 91672-07 M 7.2 NA 91672-08 M 6.9 11.3 91672-09 F 7.5 12.3 91672-10 F 7.7 11.9

NA = NOT APPLICABLE**Page 1025 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91672-11 F 7.5 NA 91672-12 F 7.1 10.6 91672-13 F 7.0 11.1 91672-14 F 7.0 9.4

MALES MEAN 7.3 11.0 FEMALES MEAN 7.3 11.1

MALES MEAN 6.8 9.6 S.D. 0.87 1.60 S.E. 0.25 0.46 N 12 12

FEMALES MEAN 6.6 9.1 S.D. 0.77 1.48 S.E. 0.22 0.43 N 12 12

NA = NOT APPLICABLE**Page 1026 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91632-01 M 7.5 9.2 91632-02 M 7.6 8.5 91632-03 M 7.3 9.2 91632-04 M 7.6 9.7 91632-05 F 7.0 8.7 91632-06 F 7.0 8.7 91632-07 F 6.8 8.5 91632-08 F 7.3 8.7 91632-09 F 7.2 8.9 91632-10 F 6.5 8.6 91632-11 F 6.9 8.7 91632-12 F 7.8 9.5 91632-13 F 7.2 8.9 91632-14 F 7.8 9.2 91632-15 F 5.9 NA

MALES MEAN 7.5 9.2 FEMALES MEAN 7.0 8.8

91640-03 F 4.7 6.5 91640-04 M 8.2 12.0 91640-05 M 7.7 10.1 91640-06 M 7.9 11.2 91640-07 F 8.2 11.7 91640-08 F 8.2 11.7 91640-09 F 7.2 10.3

NA = NOT APPLICABLE**Page 1027 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 11 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91640-10 F 7.1 10.7 91640-11 F 7.4 9.9 91640-12 F 7.9 11.5

MALES MEAN 7.9 11.1 FEMALES MEAN 7.2 10.3

91642-01 M 7.7 9.2 91642-02 M 8.0 10.1 91642-03 M 7.4 9.4 91642-04 M 7.1 9.3 91642-05 F 7.6 9.6 91642-06 F 7.0 9.2 91642-07 F 7.3 9.6 91642-08 F 6.8 8.2 91642-09 F 7.6 9.0 91642-10 F 7.1 9.0 91642-11 F 7.8 9.4 91642-12 F 6.2 6.2 91642-13 F 7.0 8.6 91642-14 F 6.4 8.6**Page 1028 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 12 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91642-15 M 7.9 9.5

MALES MEAN 7.6 9.5 FEMALES MEAN 7.1 8.7

91647-03 M 8.0 10.3 91647-04 M 7.3 9.7 91647-05 M 7.9 9.8 91647-06 M 7.6 9.7 91647-07 M 7.2 9.3 91647-08 M 7.8 9.7 91647-09 F 7.4 9.8 91647-10 F 7.9 9.5 91647-11 F 7.0 8.8 91647-12 F 6.1 8.3 91647-13 F 5.5 7.5

MALES MEAN 7.6 9.8 FEMALES MEAN 6.8 8.8

91651-01 M 9.2 12.4 91651-02 M 8.9 11.5 91651-03 M 8.4 10.3 91651-04 M 8.9 11.8 91651-05 M 8.6 11.1 91651-06 M 8.1 9.7**Page 1029 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 13 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91651-07 M 8.9 11.4 91651-08 F 8.2 8.3 91651-09 F 8.2 10.2 91651-10 F 7.9 11.0 91651-11 F 8.7 10.7 91651-12 F 8.5 10.5

MALES MEAN 8.7 11.2 FEMALES MEAN 8.3 10.1

91659-02 M 8.5 9.6 91659-03 M 9.2 11.8 91659-04 M 8.8 11.0 91659-05 M 9.2 10.7 91659-06 M 8.6 11.4 91659-07 M 8.9 11.5 91659-08 F 8.8 11.0 91659-09 F 8.6 10.3 91659-10 F 8.4 10.5 91659-11 F 8.5 10.4 91659-12 F 8.2 10.2**Page 1030 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 14 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91659-13 F 8.1 10.5

MALES MEAN 8.9 11.0 FEMALES MEAN 8.4 10.5

91661-01 M 6.5 8.9 91661-02 M 7.4 9.5 91661-03 M 7.1 10.2 91661-04 M 6.6 9.8 91661-05 M 6.7 9.7 91661-06 M 7.0 10.2 91661-07 M 6.3 9.5 91661-08 M 6.6 9.2 91661-09 M 7.3 9.9 91661-10 M 6.6 9.6 91661-11 M 6.3 8.5 91661-12 F 6.1 8.8 91661-13 F 4.0 5.5 91661-14 F 5.5 7.3 91661-15 F 5.9 8.7 91661-16 F 6.7 9.0**Page 1031 of 1107**TABLE A55 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91661-17 F 6.5 9.4

MALES MEAN 6.8 9.5 FEMALES MEAN 5.8 8.1

91663-01 M 7.5 9.8 91663-03 M 8.1 10.4 91663-04 M 8.3 10.8 91663-05 M 8.3 8.4 91663-06 M 7.6 10.0 91663-07 M 8.2 10.5 91663-08 F 8.1 11.0 91663-09 F 8.4 10.3 91663-10 F 8.3 11.3 91663-11 F 7.2 9.4 91663-12 F 7.2 9.3 91663-13 F 8.1 10.6 91663-14 F 7.1 NA 91663-15 F 8.4 11.2

MALES MEAN 8.0 10.0 FEMALES MEAN 7.9 10.4

91669-01 M 7.3 9.9 91669-02 M 6.3 7.2 91669-03 M 6.9 7.1

NA = NOT APPLICABLE**Page 1032 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 16 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

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POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91669-04 M 7.7 10.1 91669-05 M 7.6 NA 91669-06 M 7.4 10.2 91669-07 M 7.8 10.7 91669-08 M 7.1 9.7 91669-09 M 7.3 8.9 91669-10 F 7.6 10.4 91669-11 F 6.5 NA 91669-12 F 6.7 9.3 91669-13 F 6.9 9.3 91669-14 F 6.6 9.1 91669-15 F 6.7 NA 91669-16 F 6.2 NA

MALES MEAN 7.3 9.2 FEMALES MEAN 6.7 9.5

91673-01 M 8.3 10.2 91673-02 M 7.5 8.9 91673-03 M 7.4 9.0 91673-04 M 7.8 9.7 91673-05 M 7.0 8.4 91673-06 M 7.8 9.5 91673-07 F 7.1 8.6 91673-08 F 7.0 8.9 91673-09 F 7.2 8.9

NA = NOT APPLICABLE**Page 1033 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 17 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

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POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91673-10 F 7.1 8.9 91673-11 F 6.7 8.7 91673-12 F 6.6 8.6 91673-13 F 6.4 8.4 91673-14 F 6.6 8.7 91673-15 F 7.2 8.3 91673-16 F 6.3 7.2

MALES MEAN 7.6 9.3 FEMALES MEAN 6.8 8.5

91683-01 M 8.3 11.6 91683-02 M 8.3 11.0 91683-03 M 7.8 11.1 91683-04 M 7.3 10.4 91683-05 M 8.2 11.0 91683-06 M 7.8 10.5 91683-07 F 7.7 10.8 91683-08 F 7.8 10.7 91683-09 F 7.8 10.9 91683-10 F 6.8 9.2 91683-11 F 7.6 10.5**Page 1034 of 1107**TABLE A55 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91683-12 F 7.2 9.9

MALES MEAN 8.0 10.9 FEMALES MEAN 7.5 10.3

91685-01 M 8.3 10.9 91685-02 M 8.4 11.8 91685-03 M 8.6 11.6 91685-04 M 8.3 11.2 91685-05 M 8.9 11.5 91685-06 F 8.3 11.4 91685-07 F 7.6 10.1 91685-08 F 8.5 NA 91685-09 F 7.8 9.4 91685-10 F 7.0 9.9

MALES MEAN 8.5 11.4 FEMALES MEAN 7.8 10.2

MALES MEAN 7.9 10.2 S.D. 0.60 0.87 S.E. 0.17 0.25 N 12 12

FEMALES MEAN 7.3 9.5 S.D. 0.74 0.88 S.E. 0.22 0.25 N 12 12

NA = NOT APPLICABLE**Page 1035 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 19 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

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POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91620-02 M 7.5 10.0 91620-03 M 7.2 9.8 91620-04 M 7.5 10.7 91620-05 M 7.1 8.9 91620-06 M 7.8 10.3 91620-07 M 7.8 10.4 91620-08 M 7.7 10.0 91620-09 M 8.2 10.5 91620-10 F 7.0 8.8 91620-11 F 6.6 9.2 91620-12 F 6.3 8.3 91620-13 F 7.2 9.7 91620-14 F 6.9 8.8

MALES MEAN 7.6 10.1 FEMALES MEAN 6.8 9.0

91628-02 F 8.0 9.7 91628-03 M 7.9 10.3 91628-04 M 7.7 9.5 91628-05 M 8.2 10.1 91628-06 M 8.2 9.8 91628-07 M 7.4 9.9 91628-08 M 7.1 8.4 91628-09 M 7.6 9.8 91628-10 F 7.0 9.2**Page 1036 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 20 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

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POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91628-11 F 7.4 9.3 91628-12 F 7.2 9.6 91628-13 F 7.7 9.2 91628-14 F 7.8 9.2 91628-15 F 7.5 9.7

MALES MEAN 7.7 9.7 FEMALES MEAN 7.5 9.4

91631-01 M 7.2 NA 91631-02 M 8.2 11.4 91631-03 M 6.8 9.9 91631-04 M 8.9 11.6 91631-05 M 8.3 10.6 91631-06 M 7.7 10.1 91631-07 M 8.1 11.0 91631-08 M 5.6 NA 91631-09 M 7.6 10.0 91631-10 F 7.2 9.3 91631-11 F 7.7 9.6 91631-12 F 8.1 10.5 91631-13 F 7.2 9.4 91631-14 F 6.9 9.1

NA = NOT APPLICABLE**Page 1037 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 21 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

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POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91631-15 F 7.3 10.3

MALES MEAN 7.6 10.7 FEMALES MEAN 7.4 9.7

91636-01 M 8.2 10.4 91636-02 M 8.0 9.9 91636-03 M 8.2 9.8 91636-04 M 7.3 9.7 91636-05 F 7.6 9.0 91636-06 F 8.0 9.8 91636-07 F 7.3 8.8 91636-08 F 7.6 9.2 91636-09 F 6.2 7.6 91636-10 F 5.9 7.7 91636-11 F 7.0 8.5 91636-12 F 6.8 8.4 91636-13 F 7.0 8.9

MALES MEAN 7.9 10.0 FEMALES MEAN 7.0 8.7

91649-01 M 6.8 8.0 91649-02 M 7.3 8.7 91649-03 M 8.1 8.9 91649-04 M 6.7 8.0**Page 1038 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 22 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

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POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91649-05 M 7.6 7.3 91649-06 M 7.9 6.6 91649-07 F 7.6 10.3 91649-08 F 7.4 9.0 91649-09 F 6.4 8.4 91649-10 F 7.3 7.9 91649-11 F 7.4 9.5 91649-12 F 7.5 9.7 91649-13 F 7.9 10.3 91649-14 F 6.2 6.8 91649-15 F 6.5 7.6 91649-16 F 7.5 9.7

MALES MEAN 7.4 7.9 FEMALES MEAN 7.2 8.9

91650-02 M 7.9 10.2 91650-03 M 6.9 9.6 91650-04 M 7.6 9.6 91650-05 M 6.7 7.9 91650-06 M 7.9 10.4 91650-07 M 7.6 9.9 91650-08 M 8.2 10.5 91650-09 F 7.1 9.6 91650-10 F 6.2 8.9 91650-11 F 7.9 10.9**Page 1039 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 23 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

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POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91650-12 F 4.9 6.6 91650-13 F 7.8 10.1 91650-14 F 7.7 10.4

MALES MEAN 7.5 9.7 FEMALES MEAN 6.9 9.4

91656-03 M 8.4 10.9 91656-04 M 7.2 10.1 91656-06 M 7.3 9.7 91656-07 M 7.3 9.3 91656-08 F 6.9 8.4 91656-09 F 7.3 9.5 91656-10 F 7.1 9.7 91656-11 F 7.7 9.9 91656-12 F 7.3 9.6 91656-13 F 7.4 9.4 91656-14 F 6.7 NA 91656-15 F 7.1 9.7

MALES MEAN 7.6 10.0 FEMALES MEAN 7.2 9.5

91671-03 M 7.0 9.8 91671-04 M 7.6 10.8 91671-05 M 7.7 8.7

NA = NOT APPLICABLE**Page 1040 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 24 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

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POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91671-06 M 7.4 9.9 91671-08 M 6.9 10.0 91671-09 M 6.9 10.0 91671-10 F 6.4 9.0 91671-12 F 6.8 10.2 91671-13 F 7.1 9.6 91671-14 F 6.9 9.6 91671-15 F 6.0 8.4

MALES MEAN 7.3 9.9 FEMALES MEAN 6.6 9.4

91675-01 M 7.0 8.4 91675-02 M 8.0 8.2 91675-03 M 7.0 8.6 91675-05 M 8.3 9.8 91675-06 F 8.5 10.8 91675-07 F 7.4 9.6 91675-08 F 8.1 10.3 91675-09 F 7.6 9.0 91675-10 F 7.3 8.8 91675-11 F 6.6 NA 91675-12 F 7.3 9.6 91675-13 F 8.0 9.6

NA = NOT APPLICABLE**Page 1041 of 1107**TABLE A55 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91675-14 F 5.9 NA

MALES MEAN 7.6 8.8 FEMALES MEAN 7.4 9.7

91677-01 M 8.3 NA 91677-02 M 7.8 10.5 91677-03 F 7.6 9.6 91677-04 F 7.3 NA 91677-05 F 8.1 9.8

MALES MEAN 8.1 10.5 FEMALES MEAN 7.7 9.7

91679-03 M 7.8 10.6 91679-04 M 8.3 11.4 91679-05 M 8.7 10.7 91679-06 M 6.9 NA 91679-07 M 8.8 8.9 91679-08 M 9.0 12.2 91679-09 F 8.0 11.4 91679-10 F 8.2 NA

NA = NOT APPLICABLE**Page 1042 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 26 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

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POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91679-12 F 7.5 10.6

MALES MEAN 8.3 10.8 FEMALES MEAN 7.9 11.0

91684-01 M 7.9 9.7 91684-02 M 7.3 8.6 91684-03 M 7.2 8.9 91684-04 M 7.2 8.4 91684-05 M 6.2 8.0 91684-06 M 6.1 7.5 91684-07 M 7.7 8.9 91684-08 M 7.4 8.8 91684-09 M 7.2 8.2 91684-10 F 7.0 8.1 91684-11 F 6.6 8.0 91684-12 F 7.0 8.0 91684-13 F 6.3 7.7 91684-14 F 6.7 6.3 91684-15 F 6.9 8.6 91684-16 F 6.8 7.9

MALES MEAN 7.1 8.6 FEMALES MEAN 6.8 7.8

MALES MEAN 7.6 9.7 S.D. 0.33 0.88 S.E. 0.10 0.25 N 12 12

FEMALES MEAN 7.2 9.4 S.D. 0.40 0.75 S.E. 0.11 0.22 N 12 12**Page 1043 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 27 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

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POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 4: 175 PPM

--------------------------------------- 91622-04 M 7.1 8.6 91622-05 M 7.0 8.1 91622-06 M 6.6 8.0 91622-07 M 6.7 7.7 91622-08 M 6.9 NA 91622-09 M 7.1 8.3 91622-10 M 6.8 7.1 91622-11 F 5.8 7.7 91622-12 F 6.6 8.1 91622-13 F 6.5 NA 91622-14 F 6.1 NA

MALES MEAN 6.9 8.0 FEMALES MEAN 6.3 7.9

91626-02 M 7.0 9.8 91626-03 M 7.0 9.9 91626-04 M 7.0 9.8 91626-05 M 7.3 10.5 91626-06 M 7.1 9.6 91626-07 M 7.0 9.6 91626-08 F 5.7 8.4 91626-09 F 6.3 9.4 91626-10 F 6.1 9.1 91626-11 F 6.0 7.9 91626-12 F 6.9 9.6

NA = NOT APPLICABLE**Page 1044 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 28 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

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POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 4: 175 PPM

--------------------------------------- 91626-13 F 6.5 9.4 91626-14 F 6.4 8.4

MALES MEAN 7.1 9.9 FEMALES MEAN 6.3 8.9

91643-02 M 7.3 9.3 91643-03 M 7.0 9.0 91643-04 M 7.1 9.4 91643-05 M 8.1 9.4 91643-06 M 7.3 9.4 91643-07 M 7.5 9.1 91643-08 M 7.6 9.7 91643-09 M 7.5 9.0 91643-10 F 7.5 9.5 91643-11 F 7.0 8.9 91643-12 F 7.2 9.5

MALES MEAN 7.4 9.3 FEMALES MEAN 7.2 9.3

91654-04 M 6.0 NA 91654-05 M 6.9 NA 91654-06 M 5.9 NA 91654-07 M 6.8 NA 91654-08 M 6.4 NA

NA = NOT APPLICABLE**Page 1045 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 29 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

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POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 4: 175 PPM

--------------------------------------- 91654-09 M 6.4 NA 91654-11 M 7.4 NA 91654-12 M 5.9 NA 91654-13 M 6.6 NA 91654-14 F 6.6 NA 91654-15 F 6.2 NA 91654-16 F 6.3 NA 91654-17 F 5.8 NA 91654-18 F 5.8 NA

MALES MEAN 6.5 FEMALES MEAN 6.1

91657-01 F 6.1 NA 91657-02 M 6.8 NA 91657-03 M 6.8 NA 91657-04 M 7.7 9.1 91657-05 M 6.9 8.4 91657-06 M 7.6 9.0 91657-07 M 7.2 NA 91657-08 F 5.6 NA 91657-09 F 7.0 9.0 91657-10 F 6.4 8.0 91657-11 F 7.3 9.3 91657-12 F 7.4 9.0

NA = NOT APPLICABLE**Page 1046 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 30 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

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POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 4: 175 PPM

--------------------------------------- 91657-13 F 6.9 8.3

MALES MEAN 7.2 8.8 FEMALES MEAN 6.7 8.7

91662-03 M 8.3 11.4 91662-04 M 8.0 11.2 91662-05 M 6.9 9.6 91662-06 M 8.0 11.1 91662-07 F 6.6 NA 91662-08 F 6.9 NA 91662-09 F 8.7 12.3 91662-10 F 7.7 9.9 91662-11 F 7.7 10.5

MALES MEAN 7.8 10.8 FEMALES MEAN 7.5 10.9

91666-02 M 7.6 11.8 91666-03 M 7.5 10.7 91666-04 M 8.1 10.9 91666-05 M 8.4 12.2 91666-06 M 7.6 11.6 91666-07 M 7.1 10.4 91666-08 M 8.1 11.4 91666-09 F 8.1 10.6

NA = NOT APPLICABLE**Page 1047 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 31 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

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POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 4: 175 PPM

--------------------------------------- 91666-10 F 7.0 10.1 91666-11 F 7.3 9.7

MALES MEAN 7.8 11.3 FEMALES MEAN 7.5 10.1

91676-01 M 9.8 12.8 91676-02 M 8.7 11.9 91676-03 M 7.7 10.5 91676-04 M 8.1 11.4 91676-05 M 8.5 11.0 91676-06 F 8.9 12.0 91676-07 F 7.4 10.4 91676-08 F 9.3 11.8 91676-09 F 9.2 12.2 91676-11 F 7.7 11.1

MALES MEAN 8.6 11.5 FEMALES MEAN 8.5 11.5

91678-01 M 7.7 11.4 91678-02 M 6.7 9.6 91678-03 M 6.8 9.1 91678-04 M 6.4 9.4 91678-05 F 5.8 NA 91678-06 F 7.5 10.8

NA = NOT APPLICABLE**Page 1048 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 32 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

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POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 4: 175 PPM

--------------------------------------- 91678-07 F 7.1 10.1 91678-08 F 7.5 10.7 91678-09 F 6.9 9.0 91678-10 F 6.8 8.3 91678-11 F 7.3 9.9 91678-12 F 7.1 10.4 91678-13 F 7.3 10.0 91678-14 F 7.5 10.6

MALES MEAN 6.9 9.9 FEMALES MEAN 7.1 10.0

91681-04 M 7.2 9.5 91681-05 M 7.0 7.8 91681-06 M 6.5 8.8 91681-07 M 6.2 NA 91681-09 M 7.5 9.9 91681-10 M 7.0 9.4 91681-11 F 5.7 5.2 91681-12 F 7.2 10.1 91681-13 F 6.3 7.7 91681-14 F 6.5 8.3

NA = NOT APPLICABLE**Page 1049 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 33 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

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POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 4: 175 PPM

--------------------------------------- 91681-15 F 7.2 10.0

MALES MEAN 6.9 9.1 FEMALES MEAN 6.6 8.3

91682-02 F 6.6 NA 91682-04 M 6.9 7.6 91682-05 M 7.2 NA 91682-06 M 7.8 9.9 91682-07 M 7.0 NA 91682-08 M 7.6 10.3 91682-09 M 6.1 NA 91682-10 M 7.5 NA 91682-11 M 6.6 6.8 91682-12 F 6.3 7.6 91682-13 F 6.0 NA

MALES MEAN 7.1 8.7 FEMALES MEAN 6.3 7.6

MALES MEAN 7.3 9.7 S.D. 0.58 1.17 S.E. 0.18 0.37 N 11 10

FEMALES MEAN 6.9 9.3 S.D. 0.73 1.29 S.E. 0.22 0.41 N 11 10

NA = NOT APPLICABLE**Page 1050 of 1107**TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 34 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

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POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91624-01 M 7.8 9.8 91624-02 M 8.0 9.7 91624-03 M 8.0 10.2 91624-04 M 7.1 8.7 91624-05 M 7.9 9.7 91624-06 M 7.7 9.0 91624-07 M 7.6 8.8 91624-08 M 7.4 9.7 91624-09 F 6.0 8.1 91624-10 F 6.8 9.2 91624-11 F 7.0 9.0 91624-12 F 7.2 8.7 91624-13 F 6.3 8.4

MALES MEAN 7.7 9.5 FEMALES MEAN 6.7 8.7

91625-01 M 7.6 11.0 91625-02 M 7.8 11.0 91625-03 M 7.4 11.4 91625-04 M 7.5 10.1 91625-05 M 8.5 11.9 91625-06 F 7.9 10.4 91625-07 F 7.4 10.6 91625-08 F 7.3 11.1 91625-09 F 6.9 9.9**Page 1051 of 1107**TABLE A55 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91625-10 F 7.9 11.8 91625-11 F 7.2 9.8 91625-12 F 7.3 10.3 91625-13 F 7.5 10.3 91625-14 F 7.6 10.4

MALES MEAN 7.8 11.1 FEMALES MEAN 7.4 10.5

91627-01 M 7.4 10.0 91627-02 M 9.2 9.8 91627-03 M 8.3 10.6 91627-04 M 8.6 10.9 91627-05 M 8.0 10.4 91627-06 M 7.7 9.9 91627-07 M 8.8 10.9 91627-08 M 8.0 10.2 91627-09 F 8.8 10.5 91627-10 F 7.7 9.8 91627-11 F 7.3 9.4 91627-12 F 7.5 9.7**Page 1052 of 1107**TABLE A55 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91627-13 F 8.2 9.6

MALES MEAN 8.3 10.3 FEMALES MEAN 7.9 9.8

91634-01 M 7.7 10.1 91634-02 M 7.9 9.8 91634-03 M 7.8 10.3 91634-04 M 8.0 10.4 91634-05 M 6.8 8.6 91634-06 M 7.7 10.1 91634-07 F 7.4 9.9 91634-08 F 7.4 9.6 91634-09 F 7.0 9.3 91634-10 F 7.4 9.2 91634-11 F 7.0 9.4 91634-12 F 7.5 9.3 91634-13 F 7.4 9.8

MALES MEAN 7.7 9.9 FEMALES MEAN 7.3 9.5

91635-02 M 8.7 11.6 91635-03 M 9.7 11.8 91635-04 M 9.6 12.3 91635-05 M 8.6 10.9**Page 1053 of 1107**TABLE A55 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91635-06 M 8.6 10.8 91635-07 M 8.5 11.2 91635-08 F 8.8 10.5 91635-09 F 8.7 10.9 91635-10 F 8.3 10.0 91635-11 F 8.2 10.9 91635-12 F 8.8 11.4 91635-13 F 8.7 10.1

MALES MEAN 9.0 11.4 FEMALES MEAN 8.6 10.6

91638-01 M 7.0 8.8 91638-02 M 7.5 10.0 91638-03 M 7.8 10.0 91638-04 M 7.3 9.8 91638-05 M 7.5 10.0 91638-06 M 7.0 9.6 91638-07 M 6.2 8.5 91638-08 M 7.1 9.8 91638-09 M 7.1 9.4 91638-10 F 6.3 9.1 91638-11 F 7.2 9.2 91638-12 F 6.5 8.4 91638-13 F 6.6 9.4 91638-14 F 6.9 9.2**Page 1054 of 1107**TABLE A55 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91638-15 F 6.8 7.9 91638-16 F 6.2 9.0

MALES MEAN 7.2 9.5 FEMALES MEAN 6.6 8.9

91652-03 M 7.8 11.2 91652-04 M 8.5 11.9 91652-05 M 8.7 12.5 91652-06 M 7.8 11.4 91652-07 M 9.0 13.4 91652-08 M 8.6 12.1 91652-09 M 8.2 11.9 91652-10 M 8.1 11.6 91652-11 F 6.4 7.0 91652-12 F 8.2 12.1 91652-13 F 7.4 9.5

MALES MEAN 8.3 12.0 FEMALES MEAN 7.3 9.5

91655-01 M 7.7 10.1 91655-02 M 7.3 9.2 91655-03 M 6.3 8.4 91655-04 M 7.6 10.9 91655-05 F 7.5 10.8**Page 1055 of 1107**TABLE A55 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91655-06 F 6.6 9.4 91655-07 F 7.3 10.7 91655-08 F 6.1 NA 91655-09 F 7.4 10.5 91655-10 F 6.3 9.4 91655-11 F 7.0 10.2 91655-12 F 5.8 8.2

MALES MEAN 7.2 9.7 FEMALES MEAN 6.8 9.9

91658-01 M 8.2 9.9 91658-02 M 7.5 8.8 91658-03 M 8.0 10.6 91658-04 M 7.6 9.6 91658-05 M 7.5 10.0 91658-06 M 7.7 8.4 91658-07 M 8.2 10.7 91658-08 M 7.7 8.9 91658-09 F 7.1 9.1 91658-10 F 7.6 9.0 91658-11 F 7.0 9.3 91658-12 F 7.0 8.5

NA = NOT APPLICABLE**Page 1056 of 1107**TABLE A55 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91658-13 F 7.6 9.4

MALES MEAN 7.8 9.6 FEMALES MEAN 7.3 9.1

91667-01 M 6.6 9.3 91667-02 M 7.6 10.9 91667-03 M 6.7 8.9 91667-04 M 7.0 8.4 91667-05 M 6.7 9.0 91667-06 F 7.3 10.2 91667-07 F 6.5 9.0 91667-08 F 6.5 8.7 91667-09 F 6.5 8.8 91667-10 F 6.6 8.9 91667-11 F 6.3 8.0 91667-12 F 6.8 9.1 91667-13 F 6.8 8.8 91667-14 F 6.0 7.6 91667-15 F 7.0 9.5 91667-16 F 6.4 8.9

MALES MEAN 6.9 9.3 FEMALES MEAN 6.6 8.9

91668-03 M 8.2 11.2**Page 1057 of 1107**TABLE A55 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91668-04 M 8.3 10.2 91668-05 M 7.8 10.5 91668-06 M 8.3 11.1 91668-07 M 8.0 11.0 91668-08 M 7.7 10.4 91668-09 M 7.6 10.7 91668-10 M 7.3 9.9 91668-11 M 7.9 11.1 91668-12 F 8.0 11.2 91668-13 F 6.5 7.1 91668-14 F 7.6 10.1 91668-15 F 7.5 10.3

MALES MEAN 7.9 10.7 FEMALES MEAN 7.4 9.7

91680-01 M 7.0 9.6 91680-02 M 6.4 8.1 91680-03 M 7.6 10.0 91680-04 M 7.4 9.9 91680-05 M 6.9 9.5 91680-06 M 7.4 10.2 91680-07 M 7.6 10.1 91680-08 F 7.3 10.3 91680-09 F 7.2 9.5 91680-10 F 6.6 9.2**Page 1058 of 1107**TABLE A55 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91680-11 F 6.2 8.7 91680-12 F 6.6 9.4 91680-13 F 6.7 8.6 91680-14 F 6.2 8.0 91680-15 F 6.9 9.4

MALES MEAN 7.2 9.6 FEMALES MEAN 6.7 9.1

MALES MEAN 7.8 10.2 S.D. 0.59 0.88 S.E. 0.17 0.26 N 12 12

FEMALES MEAN 7.2 9.5 S.D. 0.60 0.62 S.E. 0.17 0.18 N 12 12 PPWTNv4.21 01/07/2014 R:01/17/2014**Page 1059 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91629-01 M 1.6 91629-02 M 1.7 91629-03 M 2.0 91629-04 M 1.4 91629-05 M 1.6 91629-06 M 2.1 91629-08 M 1.4 91629-09 M 1.8 91629-10 M 1.7 91629-11 M 1.7 91629-12 M 1.9 91629-13 F 1.8 91629-14 F 1.9 91629-15 F 1.3 91629-16 F 1.9

MALES MEAN 1.7 FEMALES MEAN 1.7

91630-03 M 3.6 91630-04 M 3.5 91630-05 M 3.1 91630-06 M 3.2 91630-07 M 3.3 91630-08 M 3.4 91630-09 F 3.0**Page 1060 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91630-10 F 3.1 91630-11 F 3.2 91630-12 F 2.9 91630-13 F 3.4 91630-14 F 2.7

MALES MEAN 3.4 FEMALES MEAN 3.1

91633-01 M 1.5 91633-02 M 2.3 91633-03 M 2.1 91633-04 M 1.3 91633-05 M 1.4 91633-06 M 1.8 91633-07 M 1.0 91633-08 F 2.0 91633-09 F 1.0 91633-10 F 2.5 91633-11 F 2.0 91633-12 F 2.0 91633-13 F 0.7 91633-14 F 1.9**Page 1061 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91633-15 F 1.6

MALES MEAN 1.6 FEMALES MEAN 1.7

91637-01 M 2.4 91637-02 M 2.3 91637-03 M 1.8 91637-04 M 2.5 91637-06 F 2.8 91637-07 F 2.4 91637-08 F 2.4 91637-09 F 2.7 91637-10 F 1.7 91637-11 F 2.8 91637-12 F 2.6 91637-13 F 2.5

MALES MEAN 2.3 FEMALES MEAN 2.5

91639-02 M 3.6 91639-03 M 3.7 91639-04 M 3.6 91639-05 M 4.1 91639-06 M 2.8**Page 1062 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91639-07 M 3.7 91639-08 M 2.8 91639-09 F 3.1 91639-10 F 2.9

MALES MEAN 3.5 FEMALES MEAN 3.0

91644-01 M 1.7 91644-02 M 1.6 91644-03 M 1.7 91644-04 M 0.7 91644-05 M 1.5 91644-06 M 1.2 91644-07 M 1.8 91644-08 M 1.4 91644-09 M 1.3 91644-10 M 1.2 91644-11 F 1.3 91644-12 F 1.1 91644-13 F 1.0 91644-14 F 1.4 91644-15 F 1.2 91644-16 F 1.2

MALES MEAN 1.4 FEMALES MEAN 1.2**Page 1063 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91645-01 M 2.9 91645-02 M 2.8 91645-03 M 3.0 91645-04 M 3.2 91645-05 M 3.8 91645-06 M 2.9 91645-07 M 3.1 91645-09 M 3.6 91645-10 F 3.2 91645-11 F 2.2 91645-12 F 3.0 91645-13 F 3.1 91645-14 F 3.1 91645-15 F 2.9 91645-16 F 3.5

MALES MEAN 3.2 FEMALES MEAN 3.0

91648-02 M 3.5 91648-03 M 3.6 91648-04 M 3.8 91648-05 M 3.7 91648-06 M 3.4 91648-07 M 3.3 91648-08 M 4.2**Page 1064 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91648-09 M 3.6 91648-10 F 3.4 91648-11 F 3.0 91648-12 F 3.7 91648-13 F 3.5 91648-14 F 3.8

MALES MEAN 3.6 FEMALES MEAN 3.5

91653-01 M 1.9 91653-02 M 3.1 91653-03 M 1.2 91653-04 M 2.7 91653-05 M 2.4 91653-06 M 2.1 91653-07 F 2.0 91653-08 F 2.4 91653-09 F 2.3 91653-10 F 1.3 91653-11 F 2.7 91653-12 F 1.8 91653-13 F 2.0 91653-14 F 2.4**Page 1065 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91653-15 F 1.4

MALES MEAN 2.2 FEMALES MEAN 2.0

91660-02 M 3.4 91660-03 M 3.6 91660-04 M 3.0 91660-05 M 3.9 91660-06 M 3.8 91660-07 M 3.4 91660-08 M 3.8 91660-09 M 3.6 91660-10 F 3.0 91660-11 F 2.8 91660-12 F 2.6 91660-13 F 3.1 91660-14 F 3.0

MALES MEAN 3.6 FEMALES MEAN 2.9

91670-01 M 1.8 91670-02 M 2.1 91670-03 M 2.3 91670-04 M 2.2**Page 1066 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91670-05 M 2.7 91670-06 M 2.3 91670-07 M 2.2 91670-08 M 2.1 91670-09 F 2.3 91670-10 F 2.8 91670-11 F 1.2 91670-12 F 2.0 91670-13 F 2.6 91670-14 F 1.9

MALES MEAN 2.2 FEMALES MEAN 2.1

91672-02 M 3.5 91672-03 M 3.4 91672-04 M 4.2 91672-05 M 2.0 91672-06 M 4.8 91672-08 M 4.4 91672-09 F 4.8 91672-10 F 4.2 91672-12 F 3.5 91672-13 F 4.1**Page 1067 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 1: 0 PPM

--------------------------------------- 91672-14 F 2.4

MALES MEAN 3.7 FEMALES MEAN 3.8

MALES MEAN 2.7 S.D. 0.88 S.E. 0.25 N 12

FEMALES MEAN 2.5 S.D. 0.80 S.E. 0.23 N 12**Page 1068 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91632-01 M 1.7 91632-02 M 0.9 91632-03 M 1.9 91632-04 M 2.1 91632-05 F 1.7 91632-06 F 1.7 91632-07 F 1.7 91632-08 F 1.4 91632-09 F 1.7 91632-10 F 2.1 91632-11 F 1.8 91632-12 F 1.7 91632-13 F 1.7 91632-14 F 1.4

MALES MEAN 1.7 FEMALES MEAN 1.7

91640-03 F 1.8 91640-04 M 3.8 91640-05 M 2.4 91640-06 M 3.3 91640-07 F 3.5 91640-08 F 3.5 91640-09 F 3.1 91640-10 F 3.6**Page 1069 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91640-11 F 2.5 91640-12 F 3.6

MALES MEAN 3.2 FEMALES MEAN 3.1

91642-01 M 1.5 91642-02 M 2.1 91642-03 M 2.0 91642-04 M 2.2 91642-05 F 2.0 91642-06 F 2.2 91642-07 F 2.3 91642-08 F 1.4 91642-09 F 1.4 91642-10 F 1.9 91642-11 F 1.6 91642-12 F 0.0 91642-13 F 1.6 91642-14 F 2.2 91642-15 M 1.6

MALES MEAN 1.9 FEMALES MEAN 1.7

91647-03 M 2.3**Page 1070 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91647-04 M 2.4 91647-05 M 1.9 91647-06 M 2.1 91647-07 M 2.1 91647-08 M 1.9 91647-09 F 2.4 91647-10 F 1.6 91647-11 F 1.8 91647-12 F 2.2 91647-13 F 2.0

MALES MEAN 2.1 FEMALES MEAN 2.0

91651-01 M 3.2 91651-02 M 2.6 91651-03 M 1.9 91651-04 M 2.9 91651-05 M 2.5 91651-06 M 1.6 91651-07 M 2.5 91651-08 F 0.1 91651-09 F 2.0 91651-10 F 3.1 91651-11 F 2.0**Page 1071 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91651-12 F 2.0

MALES MEAN 2.5 FEMALES MEAN 1.8

91659-02 M 1.1 91659-03 M 2.6 91659-04 M 2.2 91659-05 M 1.5 91659-06 M 2.8 91659-07 M 2.6 91659-08 F 2.2 91659-09 F 1.7 91659-10 F 2.1 91659-11 F 1.9 91659-12 F 2.0 91659-13 F 2.4

MALES MEAN 2.1 FEMALES MEAN 2.1

91661-01 M 2.4 91661-02 M 2.1 91661-03 M 3.1 91661-04 M 3.2 91661-05 M 3.0**Page 1072 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91661-06 M 3.2 91661-07 M 3.2 91661-08 M 2.6 91661-09 M 2.6 91661-10 M 3.0 91661-11 M 2.2 91661-12 F 2.7 91661-13 F 1.5 91661-14 F 1.8 91661-15 F 2.8 91661-16 F 2.3 91661-17 F 2.9

MALES MEAN 2.8 FEMALES MEAN 2.3

91663-01 M 2.3 91663-03 M 2.3 91663-04 M 2.5 91663-05 M 0.1 91663-06 M 2.4 91663-07 M 2.3 91663-08 F 2.9 91663-09 F 1.9 91663-10 F 3.0 91663-11 F 2.2**Page 1073 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91663-12 F 2.1 91663-13 F 2.5 91663-15 F 2.8

MALES MEAN 2.0 FEMALES MEAN 2.5

91669-01 M 2.6 91669-02 M 0.9 91669-03 M 0.2 91669-04 M 2.4 91669-06 M 2.8 91669-07 M 2.9 91669-08 M 2.6 91669-09 M 1.6 91669-10 F 2.8 91669-12 F 2.6 91669-13 F 2.4 91669-14 F 2.5

MALES MEAN 2.0 FEMALES MEAN 2.6

91673-01 M 1.9 91673-02 M 1.4 91673-03 M 1.6**Page 1074 of 1107**TABLE A56 (F1)

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-----------------------------------------------------------------------------------------------------------------------------------

POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91673-04 M 1.9 91673-05 M 1.4 91673-06 M 1.7 91673-07 F 1.5 91673-08 F 1.9 91673-09 F 1.7 91673-10 F 1.8 91673-11 F 2.0 91673-12 F 2.0 91673-13 F 2.0 91673-14 F 2.1 91673-15 F 1.1 91673-16 F 0.9

MALES MEAN 1.7 FEMALES MEAN 1.7

91683-01 M 3.3 91683-02 M 2.7 91683-03 M 3.3 91683-04 M 3.1 91683-05 M 2.8 91683-06 M 2.7 91683-07 F 3.1 91683-08 F 2.9 91683-09 F 3.1**Page 1075 of 1107**TABLE A56 (F1)

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-----------------------------------------------------------------------------------------------------------------------------------

POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 2: 50 PPM

--------------------------------------- 91683-10 F 2.4 91683-11 F 2.9 91683-12 F 2.7

MALES MEAN 3.0 FEMALES MEAN 2.9

91685-01 M 2.6 91685-02 M 3.4 91685-03 M 3.0 91685-04 M 2.9 91685-05 M 2.6 91685-06 F 3.1 91685-07 F 2.5 91685-09 F 1.6 91685-10 F 2.9

MALES MEAN 2.9 FEMALES MEAN 2.5

MALES MEAN 2.3 S.D. 0.53 S.E. 0.15 N 12

FEMALES MEAN 2.2 S.D. 0.49 S.E. 0.14 N 12**Page 1076 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91620-02 M 2.5 91620-03 M 2.6 91620-04 M 3.2 91620-05 M 1.8 91620-06 M 2.5 91620-07 M 2.6 91620-08 M 2.3 91620-09 M 2.3 91620-10 F 1.8 91620-11 F 2.6 91620-12 F 2.0 91620-13 F 2.5 91620-14 F 1.9

MALES MEAN 2.5 FEMALES MEAN 2.2

91628-02 F 1.7 91628-03 M 2.4 91628-04 M 1.8 91628-05 M 1.9 91628-06 M 1.6 91628-07 M 2.5 91628-08 M 1.3 91628-09 M 2.2 91628-10 F 2.2**Page 1077 of 1107**TABLE A56 (F1)

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-----------------------------------------------------------------------------------------------------------------------------------

POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91628-11 F 1.9 91628-12 F 2.4 91628-13 F 1.5 91628-14 F 1.4 91628-15 F 2.2

MALES MEAN 2.0 FEMALES MEAN 1.9

91631-02 M 3.2 91631-03 M 3.1 91631-04 M 2.7 91631-05 M 2.3 91631-06 M 2.4 91631-07 M 2.9 91631-09 M 2.4 91631-10 F 2.1 91631-11 F 1.9 91631-12 F 2.4 91631-13 F 2.2 91631-14 F 2.2**Page 1078 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91631-15 F 3.0

MALES MEAN 2.7 FEMALES MEAN 2.3

91636-01 M 2.2 91636-02 M 1.9 91636-03 M 1.6 91636-04 M 2.4 91636-05 F 1.4 91636-06 F 1.8 91636-07 F 1.5 91636-08 F 1.6 91636-09 F 1.4 91636-10 F 1.8 91636-11 F 1.5 91636-12 F 1.6 91636-13 F 1.9

MALES MEAN 2.0 FEMALES MEAN 1.6

91649-01 M 1.2 91649-02 M 1.4 91649-03 M 0.8 91649-04 M 1.3**Page 1079 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91649-05 M -0.3 91649-06 M -1.3 91649-07 F 2.7 91649-08 F 1.6 91649-09 F 2.0 91649-10 F 0.6 91649-11 F 2.1 91649-12 F 2.2 91649-13 F 2.4 91649-14 F 0.6 91649-15 F 1.1 91649-16 F 2.2

MALES MEAN 0.5 FEMALES MEAN 1.8

91650-02 M 2.3 91650-03 M 2.7 91650-04 M 2.0 91650-05 M 1.2 91650-06 M 2.5 91650-07 M 2.3 91650-08 M 2.3 91650-09 F 2.5 91650-10 F 2.7 91650-11 F 3.0**Page 1080 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91650-12 F 1.7 91650-13 F 2.3 91650-14 F 2.7

MALES MEAN 2.2 FEMALES MEAN 2.5

91656-03 M 2.5 91656-04 M 2.9 91656-06 M 2.4 91656-07 M 2.0 91656-08 F 1.5 91656-09 F 2.2 91656-10 F 2.6 91656-11 F 2.2 91656-12 F 2.3 91656-13 F 2.0 91656-15 F 2.6

MALES MEAN 2.5 FEMALES MEAN 2.2

91671-03 M 2.8 91671-04 M 3.2 91671-05 M 1.0 91671-06 M 2.5**Page 1081 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91671-08 M 3.1 91671-09 M 3.1 91671-10 F 2.6 91671-12 F 3.4 91671-13 F 2.5 91671-14 F 2.7 91671-15 F 2.4

MALES MEAN 2.6 FEMALES MEAN 2.7

91675-01 M 1.4 91675-02 M 0.2 91675-03 M 1.6 91675-05 M 1.5 91675-06 F 2.3 91675-07 F 2.2 91675-08 F 2.2 91675-09 F 1.4 91675-10 F 1.5 91675-12 F 2.3 91675-13 F 1.6

MALES MEAN 1.2 FEMALES MEAN 1.9**Page 1082 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91677-02 M 2.7 91677-03 F 2.0 91677-05 F 1.7

MALES MEAN 2.7 FEMALES MEAN 1.9

91679-03 M 2.8 91679-04 M 3.1 91679-05 M 2.0 91679-07 M 0.1 91679-08 M 3.2 91679-09 F 3.4 91679-12 F 3.1

MALES MEAN 2.2 FEMALES MEAN 3.3

91684-01 M 1.8 91684-02 M 1.3 91684-03 M 1.7 91684-04 M 1.2 91684-05 M 1.8 91684-06 M 1.4 91684-07 M 1.2 91684-08 M 1.4**Page 1083 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 3: 100 PPM

--------------------------------------- 91684-09 M 1.0 91684-10 F 1.1 91684-11 F 1.4 91684-12 F 1.0 91684-13 F 1.4 91684-14 F -0.4 91684-15 F 1.7 91684-16 F 1.1

MALES MEAN 1.4 FEMALES MEAN 1.0

MALES MEAN 2.0 S.D. 0.68 S.E. 0.20 N 12

FEMALES MEAN 2.1 S.D. 0.58 S.E. 0.17 N 12**Page 1084 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 4: 175 PPM

--------------------------------------- 91622-04 M 1.5 91622-05 M 1.1 91622-06 M 1.4 91622-07 M 1.0 91622-09 M 1.2 91622-10 M 0.3 91622-11 F 1.9 91622-12 F 1.5

MALES MEAN 1.1 FEMALES MEAN 1.7

91626-02 M 2.8 91626-03 M 2.9 91626-04 M 2.8 91626-05 M 3.2 91626-06 M 2.5 91626-07 M 2.6 91626-08 F 2.7 91626-09 F 3.1 91626-10 F 3.0 91626-11 F 1.9 91626-12 F 2.7 91626-13 F 2.9**Page 1085 of 1107**TABLE A56 (F1)

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-----------------------------------------------------------------------------------------------------------------------------------

POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 4: 175 PPM

--------------------------------------- 91626-14 F 2.0

MALES MEAN 2.8 FEMALES MEAN 2.6

91643-02 M 2.0 91643-03 M 2.0 91643-04 M 2.3 91643-05 M 1.3 91643-06 M 2.1 91643-07 M 1.6 91643-08 M 2.1 91643-09 M 1.5 91643-10 F 2.0 91643-11 F 1.9 91643-12 F 2.3

MALES MEAN 1.9 FEMALES MEAN 2.1

91657-04 M 1.4 91657-05 M 1.5 91657-06 M 1.4 91657-09 F 2.0 91657-10 F 1.6 91657-11 F 2.0**Page 1086 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 4: 175 PPM

--------------------------------------- 91657-12 F 1.6 91657-13 F 1.4

MALES MEAN 1.4 FEMALES MEAN 1.7

91662-03 M 3.1 91662-04 M 3.2 91662-05 M 2.7 91662-06 M 3.1 91662-09 F 3.6 91662-10 F 2.2 91662-11 F 2.8

MALES MEAN 3.0 FEMALES MEAN 2.9

91666-02 M 4.2 91666-03 M 3.2 91666-04 M 2.8 91666-05 M 3.8 91666-06 M 4.0 91666-07 M 3.3 91666-08 M 3.3 91666-09 F 2.5 91666-10 F 3.1**Page 1087 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 4: 175 PPM

--------------------------------------- 91666-11 F 2.4

MALES MEAN 3.5 FEMALES MEAN 2.7

91676-01 M 3.0 91676-02 M 3.2 91676-03 M 2.8 91676-04 M 3.3 91676-05 M 2.5 91676-06 F 3.1 91676-07 F 3.0 91676-08 F 2.5 91676-09 F 3.0 91676-11 F 3.4

MALES MEAN 3.0 FEMALES MEAN 3.0

91678-01 M 3.7 91678-02 M 2.9 91678-03 M 2.3 91678-04 M 3.0 91678-06 F 3.3 91678-07 F 3.0 91678-08 F 3.2**Page 1088 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 4: 175 PPM

--------------------------------------- 91678-09 F 2.1 91678-10 F 1.5 91678-11 F 2.6 91678-12 F 3.3 91678-13 F 2.7 91678-14 F 3.1

MALES MEAN 3.0 FEMALES MEAN 2.8

91681-04 M 2.3 91681-05 M 0.8 91681-06 M 2.3 91681-09 M 2.4 91681-10 M 2.4 91681-11 F -0.5 91681-12 F 2.9 91681-13 F 1.4 91681-14 F 1.8 91681-15 F 2.8

MALES MEAN 2.0 FEMALES MEAN 1.7

91682-04 M 0.7 91682-06 M 2.1**Page 1089 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 4: 175 PPM

--------------------------------------- 91682-08 M 2.7 91682-11 M 0.2 91682-12 F 1.3

MALES MEAN 1.4 FEMALES MEAN 1.3

MALES MEAN 2.3 S.D. 0.85 S.E. 0.27 N 10

FEMALES MEAN 2.3 S.D. 0.62 S.E. 0.20 N 10**Page 1090 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91624-01 M 2.0 91624-02 M 1.7 91624-03 M 2.2 91624-04 M 1.6 91624-05 M 1.8 91624-06 M 1.3 91624-07 M 1.2 91624-08 M 2.3 91624-09 F 2.1 91624-10 F 2.4 91624-11 F 2.0 91624-12 F 1.5 91624-13 F 2.1

MALES MEAN 1.8 FEMALES MEAN 2.0

91625-01 M 3.4 91625-02 M 3.2 91625-03 M 4.0 91625-04 M 2.6 91625-05 M 3.4 91625-06 F 2.5 91625-07 F 3.2 91625-08 F 3.8 91625-09 F 3.0**Page 1091 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91625-10 F 3.9 91625-11 F 2.6 91625-12 F 3.0 91625-13 F 2.8 91625-14 F 2.8

MALES MEAN 3.3 FEMALES MEAN 3.1

91627-01 M 2.6 91627-02 M 0.6 91627-03 M 2.3 91627-04 M 2.3 91627-05 M 2.4 91627-06 M 2.2 91627-07 M 2.1 91627-08 M 2.2 91627-09 F 1.7 91627-10 F 2.1 91627-11 F 2.1 91627-12 F 2.2**Page 1092 of 1107**TABLE A56 (F1)

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-----------------------------------------------------------------------------------------------------------------------------------

POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91627-13 F 1.4

MALES MEAN 2.1 FEMALES MEAN 1.9

91634-01 M 2.4 91634-02 M 1.9 91634-03 M 2.5 91634-04 M 2.4 91634-05 M 1.8 91634-06 M 2.4 91634-07 F 2.5 91634-08 F 2.2 91634-09 F 2.3 91634-10 F 1.8 91634-11 F 2.4 91634-12 F 1.8 91634-13 F 2.4

MALES MEAN 2.2 FEMALES MEAN 2.2

91635-02 M 2.9 91635-03 M 2.1 91635-04 M 2.7 91635-05 M 2.3**Page 1093 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91635-06 M 2.2 91635-07 M 2.7 91635-08 F 1.7 91635-09 F 2.2 91635-10 F 1.7 91635-11 F 2.7 91635-12 F 2.6 91635-13 F 1.4

MALES MEAN 2.5 FEMALES MEAN 2.1

91638-01 M 1.8 91638-02 M 2.5 91638-03 M 2.2 91638-04 M 2.5 91638-05 M 2.5 91638-06 M 2.6 91638-07 M 2.3 91638-08 M 2.7 91638-09 M 2.3 91638-10 F 2.8 91638-11 F 2.0 91638-12 F 1.9 91638-13 F 2.8 91638-14 F 2.3**Page 1094 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91638-15 F 1.1 91638-16 F 2.8

MALES MEAN 2.4 FEMALES MEAN 2.2

91652-03 M 3.4 91652-04 M 3.4 91652-05 M 3.8 91652-06 M 3.6 91652-07 M 4.4 91652-08 M 3.5 91652-09 M 3.7 91652-10 M 3.5 91652-11 F 0.6 91652-12 F 3.9 91652-13 F 2.1

MALES MEAN 3.7 FEMALES MEAN 2.2

91655-01 M 2.4 91655-02 M 1.9 91655-03 M 2.1 91655-04 M 3.3 91655-05 F 3.3**Page 1095 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91655-06 F 2.8 91655-07 F 3.4 91655-09 F 3.1 91655-10 F 3.1 91655-11 F 3.2 91655-12 F 2.4

MALES MEAN 2.4 FEMALES MEAN 3.0

91658-01 M 1.7 91658-02 M 1.3 91658-03 M 2.6 91658-04 M 2.0 91658-05 M 2.5 91658-06 M 0.7 91658-07 M 2.5 91658-08 M 1.2 91658-09 F 2.0 91658-10 F 1.4 91658-11 F 2.3 91658-12 F 1.5**Page 1096 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91658-13 F 1.8

MALES MEAN 1.8 FEMALES MEAN 1.8

91667-01 M 2.7 91667-02 M 3.3 91667-03 M 2.2 91667-04 M 1.4 91667-05 M 2.3 91667-06 F 2.9 91667-07 F 2.5 91667-08 F 2.2 91667-09 F 2.3 91667-10 F 2.3 91667-11 F 1.7 91667-12 F 2.3 91667-13 F 2.0 91667-14 F 1.6 91667-15 F 2.5 91667-16 F 2.5

MALES MEAN 2.4 FEMALES MEAN 2.3

91668-03 M 3.0**Page 1097 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91668-04 M 1.9 91668-05 M 2.7 91668-06 M 2.8 91668-07 M 3.0 91668-08 M 2.7 91668-09 M 3.1 91668-10 M 2.6 91668-11 M 3.2 91668-12 F 3.2 91668-13 F 0.6 91668-14 F 2.5 91668-15 F 2.8

MALES MEAN 2.8 FEMALES MEAN 2.3

91680-01 M 2.6 91680-02 M 1.7 91680-03 M 2.4 91680-04 M 2.5 91680-05 M 2.6 91680-06 M 2.8 91680-07 M 2.5 91680-08 F 3.0 91680-09 F 2.3 91680-10 F 2.6**Page 1098 of 1107**TABLE A56 (F1)

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POSTNATAL DAY PUP NUMBER SEX 1- 4

----------------------------------------------------------------------------------------------------------------------------------- DAMS FROM GROUP 5: 10000 PPM

--------------------------------------- 91680-11 F 2.5 91680-12 F 2.8 91680-13 F 1.9 91680-14 F 1.8 91680-15 F 2.5

MALES MEAN 2.4 FEMALES MEAN 2.4

MALES MEAN 2.5 S.D. 0.56 S.E. 0.16 N 12

FEMALES MEAN 2.3 S.D. 0.39 S.E. 0.11 N 12 PPWTNv4.21 01/07/2014 R:01/17/2014**Page 1099 of 1107**TABLE A57 (F1 - UNSCHEDULED DEATHS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP NECROPSY FINDINGS

FOUND DEAD OR EUTHANIZED MORIBUND OR IN EXTREMIS

----------------------------------------------------------------------------------------------------------------------------------- PUP LACT GROUP 1: 0 PPM NO. SEX DAY TISSUE FINDING GRADE

----------------------------------------------------------------------------------------------------------------------------------- 91629 7 M 2 NO REMARKABLE OBSERVATIONS

91630 1 M 0 GENERAL COMMENT CANNIBALIZED P MALFORMATION CONJOINED TWIN P 2 M 0 STOMACH MILK NOT PRESENT P

91637 5 M 3 NO REMARKABLE OBSERVATIONS

91639 1 M 1 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P ABDOMINAL AND URINARY/REPRODUCTIVE

91645 8-A M 0 STOMACH MILK PRESENT P

91648 1 M 0 STOMACH MILK NOT PRESENT P

91660 1 M 0 STOMACH MILK NOT PRESENT P

91672 1 F 0 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P ABDOMINAL AND URINARY/REPRODUCTIVE 7 M 4 NO REMARKABLE OBSERVATIONS 11 F 2 NO REMARKABLE OBSERVATIONS

GRADE CODE: 1 - SLIGHT, 2 - MODERATE, 3 - MARKED, P - PRESENT A = PUP FOUND DEAD ON PND 0, BUT HAD MILK PRESENT IN STOMACH; PUP CONSIDERED BORN ALIVE**Page 1100 of 1107**TABLE A57 (F1 - UNSCHEDULED DEATHS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP NECROPSY FINDINGS

FOUND DEAD OR EUTHANIZED MORIBUND OR IN EXTREMIS

----------------------------------------------------------------------------------------------------------------------------------- PUP LACT GROUP 2: 50 PPM NO. SEX DAY TISSUE FINDING GRADE

----------------------------------------------------------------------------------------------------------------------------------- 91632 15 F 2 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P ABDOMINAL AND URINARY/REPRODUCTIVE

91640 1 M 0 STOMACH MILK NOT PRESENT P 2 M 0 STOMACH MILK NOT PRESENT P

91647 1 F 0 STOMACH MILK NOT PRESENT P

91659 1 M 1 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P ABDOMINAL AND URINARY/REPRODUCTIVE

91663 2 M 1 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P ABDOMINAL AND URINARY/REPRODUCTIVE 14 F 4 NO REMARKABLE OBSERVATIONS

91669 5 M 4 NO REMARKABLE OBSERVATIONS 11 F 4 NO REMARKABLE OBSERVATIONS 15 F 4 NO REMARKABLE OBSERVATIONS 16 F 3 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P THORACIC, ABDOMINAL AND URINARY/REPRODUCTIVE

GRADE CODE: 1 - SLIGHT, 2 - MODERATE, 3 - MARKED, P - PRESENT**Page 1101 of 1107**TABLE A57 (F1 - UNSCHEDULED DEATHS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP NECROPSY FINDINGS

FOUND DEAD OR EUTHANIZED MORIBUND OR IN EXTREMIS

----------------------------------------------------------------------------------------------------------------------------------- PUP LACT GROUP 3: 100 PPM NO. SEX DAY TISSUE FINDING GRADE

----------------------------------------------------------------------------------------------------------------------------------- 91620 1 M 0 STOMACH MILK NOT PRESENT P

91628 1 M 0 STOMACH MILK NOT PRESENT P

91631 1 M 3 NO REMARKABLE OBSERVATIONS 8 M 2 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P ABDOMINAL AND URINARY/REPRODUCTIVE MALFORMATION INTERVENTRICULAR SEPTAL DEFECT P A 1 MM IN DIAMETER OPENING IN THE ANTERIOR PORTION OF THE SEPTUM

91650 1 M 0 STOMACH MILK NOT PRESENT P

91656 1 F 0 STOMACH MILK NOT PRESENT P

91671 1 M 0 STOMACH MILK NOT PRESENT P 2 F 0 STOMACH MILK NOT PRESENT P 11 F 1 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P ABDOMINAL AND URINARY/REPRODUCTIVE

91675 4 M 1 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P ABDOMINAL AND URINIARY/REPRODUCTIVE 11 F 4 NO REMARKABLE OBSERVATIONS

91677 1 M 3 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P ABDOMINAL AND URINARY/REPRODUCTIVE

91679 1 M 0 STOMACH MILK NOT PRESENT P 2 F 0 STOMACH MILK NOT PRESENT P 10 F 2 NO REMARKABLE OBSERVATIONS

GRADE CODE: 1 - SLIGHT, 2 - MODERATE, 3 - MARKED, P - PRESENT**Page 1102 of 1107**TABLE A57 (F1 - UNSCHEDULED DEATHS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP NECROPSY FINDINGS

FOUND DEAD OR EUTHANIZED MORIBUND OR IN EXTREMIS

----------------------------------------------------------------------------------------------------------------------------------- PUP LACT GROUP 3: 100 PPM NO. SEX DAY TISSUE FINDING GRADE

----------------------------------------------------------------------------------------------------------------------------------- 91679 (CONTINUED) 11 F 1 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P ABDOMINAL AND URINARY/REPRODUCTIVE

GRADE CODE: 1 - SLIGHT, 2 - MODERATE, 3 - MARKED, P - PRESENT**Page 1103 of 1107**TABLE A57 (F1 - UNSCHEDULED DEATHS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP NECROPSY FINDINGS

FOUND DEAD OR EUTHANIZED MORIBUND OR IN EXTREMIS

----------------------------------------------------------------------------------------------------------------------------------- PUP LACT GROUP 4: 175 PPM NO. SEX DAY TISSUE FINDING GRADE

----------------------------------------------------------------------------------------------------------------------------------- 91622 1 M 1 STOMACH MILK NOT PRESENT P VARIATION THORACIC CAVITY- CONTENTS, DARK RED P 2 M 1 STOMACH MILK NOT PRESENT P 3 F 1 STOMACH MILK NOT PRESENT P 8 M 2 NO REMARKABLE OBSERVATIONS 13 F 2 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P ABDOMINAL AND URINIARY/REPRODUCTIVE 14 F 3 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P ABDOMINAL AND URINARY/REPRODUCTIVE

91626 1 F 1 STOMACH MILK NOT PRESENT P

91643 1 M 1 STOMACH MILK NOT PRESENT P

91654 1 F 0 GENERAL COMMENT CANNIBALIZED P 2 M 0 STOMACH MILK NOT PRESENT P 3 M 1 STOMACH MILK NOT PRESENT P 4 M 2 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P THORACIC, ABDOMINAL AND URINARY/REPRODUCTIVE 5 M 2 MALFORMATION INTERVENTRICULAR SEPTAL DEFECT P A 1 MM IN DIAMETER OPENING IN THE ANTERIOR PORTION OF THE SEPTUM GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P ABDOMINAL AND URINARY/REPRODUCTIVE 7 M 2 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P ABDOMINAL AND URINARY/REPRODUCTIVE MALFORMATION INTERVENTRICULAR SEPTAL DEFECT P A 2 MM IN DIAMETER OPENING IN THE ANTERIOR PORTION OF THE SEPTUM 8 M 2 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P

GRADE CODE: 1 - SLIGHT, 2 - MODERATE, 3 - MARKED, P - PRESENT**Page 1104 of 1107**TABLE A57 (F1 - UNSCHEDULED DEATHS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP NECROPSY FINDINGS

FOUND DEAD OR EUTHANIZED MORIBUND OR IN EXTREMIS

----------------------------------------------------------------------------------------------------------------------------------- PUP LACT GROUP 4: 175 PPM NO. SEX DAY TISSUE FINDING GRADE

----------------------------------------------------------------------------------------------------------------------------------- 91654 (CONTINUED) ABDOMINAL AND URINARY/REPRODUCTIVE 8 M 2 MALFORMATION INTERVENTRICULAR SEPTAL DEFECT P A 1 MM IN DIAMETER OPENING IN THE ANTERIOR PORTION OF THE SEPTUM 9 M 2 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P CRANIAL, THORACIC, ABDOMINAL AND URINARY/REPRODUCTIVE 10 M 1 STOMACH MILK NOT PRESENT P 12 M 2 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P ABDOMINAL AND URINARY/REPRODUCTIVE MALFORMATION INTERVENTRICULAR SEPTAL DEFECT P A 1 MM IN DIAMETER OPENING IN THE ANTERIOR PORTION OF THE SEPTUM 14 F 2 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P ABDOMINAL AND URINARY/REPRODUCTIVE 17 F 2 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P ABDOMINAL AND URINARY/REPRODUCTIVE

91657 1 F 2 NO REMARKABLE OBSERVATIONS 2 M 2 NO REMARKABLE OBSERVATIONS 3 M 2 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P ABDOMINAL AND URINARY/REPRODUCTIVE 7 M 2 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P ABDOMINAL AND URINARY/REPRODUCTIVE 8 F 2 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P ABDOMINAL AND URINARY/REPRODUCTIVE

91662 1 M 0 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P ABDOMINAL AND URINARY/REPRODUCTIVE 2-A F 0 STOMACH MILK PRESENT P

GRADE CODE: 1 - SLIGHT, 2 - MODERATE, 3 - MARKED, P - PRESENT A = PUP FOUND DEAD ON PND 0, BUT HAD MILK IN STOMACH; PUP CONSIDERED BORN ALIVE**Page 1105 of 1107**TABLE A57 (F1 - UNSCHEDULED DEATHS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP NECROPSY FINDINGS

FOUND DEAD OR EUTHANIZED MORIBUND OR IN EXTREMIS

----------------------------------------------------------------------------------------------------------------------------------- PUP LACT GROUP 4: 175 PPM NO. SEX DAY TISSUE FINDING GRADE

----------------------------------------------------------------------------------------------------------------------------------- 91666 1 F 1 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P ABDOMINAL AND URINIARY/REPRODUCTIVE

91678 5 F 4 NO REMARKABLE OBSERVATIONS

91681 1 F 0 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P ABDOMINAL AND URINARY/REPRODUCTIVE 2 F 0 STOMACH MILK NOT PRESENT P 8 M 1 STOMACH MILK PRESENT P MALFORMATION INTERVENTRICULAR SEPTAL DEFECT P A 1 MM IN DIAMETER OPENING IN THE ANTERIOR PORTION OF THE SEPTUM

91682 1 F 0 STOMACH MILK NOT PRESENT P VARIATION MAJOR BLOOD VESSEL VARIATION P RETROESOPHAGEAL RIGHT SUBCLAVIAN: RIGHT SUBCLAVIAN COURSES RETROESOPHAGEAL AND JOINS AORTIC ARCH ADJACENT TO DUCTUS ARTERIOSUS (NO BRACHIOCEPHALIC TRUNK) MALFORMATION VERTEBRAL AGENESIS P ANURY; SKELETAL RESULTS: ALL VERTEBRAE POSTERIOR TO THORACIC VERTEBRA #9 ABSENT, THORACIC CENTRUM #9 ABSENT; RIGHT RIB #10 WITH NO ARTICULATING HEAD; STERNOSCHISIS, STERNAL BANDS NOT JOINED, #3 THROUGH #6; COSTAL CARTILAGE ANOMALY, RIGHT COSTAL CARTILAGE #1 FUSED TO COSTAL CARTILAGE ARISING FROM 7TH CERVICAL RIB AND ASSOCIATES WITH STERNUM IN NORMAL #1 POSITION, ALL SUBSEQUENT RIGHT COSTAL CARTILAGES NOT AFFECTED; 7TH CERVICAL RIBS, FULL, RIGHT, INTERMEDIATE, LEFT MALFORMATION ANAL ATRESIA P MALFORMATION KIDNEY(S)- FUSED P MEDIAL AND MORE LATERALLY TRANSPOSED THAN NORMAL

GRADE CODE: 1 - SLIGHT, 2 - MODERATE, 3 - MARKED, P - PRESENT**Page 1106 of 1107**TABLE A57 (F1 - UNSCHEDULED DEATHS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8 SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP NECROPSY FINDINGS

FOUND DEAD OR EUTHANIZED MORIBUND OR IN EXTREMIS

----------------------------------------------------------------------------------------------------------------------------------- PUP LACT GROUP 5: 10000 PPM NO. SEX DAY TISSUE FINDING GRADE

----------------------------------------------------------------------------------------------------------------------------------- 91635 1 M 0 STOMACH MILK NOT PRESENT P

91652 1 M 0 STOMACH MILK NOT PRESENT P 2 U 0 GENERAL COMMENT CANNIBALIZED P

91655 8 F 2 NO REMARKABLE OBSERVATIONS 13 F 1 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P ABDOMINAL AND URINARY/REPRODUCTIVE

91668 1 U 0 GENERAL COMMENT CANNIBALIZED P 2 M 0 STOMACH MILK NOT PRESENT P

GRADE CODE: 1 - SLIGHT, 2 - MODERATE, 3 - MARKED, P - PRESENT PPNRDv4.24 02/24/2014 R:02/24/2014**Page 1107 of 1107**