FINAL REPORT

Contents: Volume 1 of 4

Text, Summary Tables, and Appendices A - F

Study Title: An Inhalation Reproduction/Developmental Toxicity

Screening Study of 2-Bromo-3,3,3-Trifluoropropene in Rats

Laboratory Project ID: WIL-65501

Author: Tammye L. Edwards, BS

Test Guideline: OECD Guideline 421

Study Completion Date: 21 March 2014

Performing Laboratory: WIL Research

1407 George Road

Ashland, OH 44805-8946

Sponsor: American Pacific Corporation

3883 Howard Hughes Parkway, Suite 700

Las Vegas, NV 89169

Total Number of Pages: 1107

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WIL-65501 

American Pacific Corporation 

COMPLIANCE STATEMENT 

The following is a detailed description of all differences between the practices used in this study, 

WIL-65501, and those required by the United States EPA GLP Standards 40 CFR Part 792 

(1 8 September 1989); the OECD Principles of GLP [C(97) 186/Final] (26 November 1997); WIL 

Research’s SOPS; and the study protocol as approved by the Sponsor: 

A Certificate of Analysis for the test substance was provided by the Sponsor 

(presented in Appendix B); the characterization analyses were not compliant with 

GLP standards. 

This protocol was designed in general accordance with the OECD Guidelines for the Testing of 

Chemicals, Guideline 42 I, ReproductiodDevelopmental Toxicity Screening Test, 27 July 1995. 

Typed Name of Signer: Tarnmye L. Edwards, BS 

Typed Name of Laboratory: WIL Research 

Sponsor: 

Signature 

Typed Name of Signer: Bradford Colton 

Typed Name of Company: American Pacific Corporation 

Date 

Submitter: 

Signature Date 

Typed Name of Signer: 

Typed Name of Company: 

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TABLE OF CONTENTS

VOLUME 1 Page

Compliance Statement...............................................................................2

Table of Contents.......................................................................................3

Index of Tables...........................................................................................7

Index of Appendices.................................................................................10

1. Summary...................................................................................................14

1.1. Objective ....................................................................................................14

1.2. Study Design..............................................................................................14

1.3. Results........................................................................................................15

1.4. Conclusion .................................................................................................18

2. Introduction..............................................................................................20

2.1. General Study Information ........................................................................20

2.2. Key Study Dates ........................................................................................20

2.3. Participating Scientists...............................................................................21

2.4. Contributing Scientists and Test Sites.......................................................21

2.5. Principal Investigators and Test Sites........................................................21

2.6. WIL Research Key Study Personnel..........................................................21

3. Study Design.............................................................................................22

4. Experimental Procedures - Materials and Methods.............................24

4.1. Test Substance and Control Substance ......................................................24

4.1.1. Test Substance ...........................................................................................24

4.1.2. Control Substance ......................................................................................24

4.2. Exposure Methods .....................................................................................25

4.3. Test Atmosphere Generation Methods......................................................25

4.3.1. Exposure Chambers 2, 3, and 4 .................................................................25

4.3.2. Exposure Chamber 5B (10,000 ppm) ........................................................27

4.4. Methods for Characterization of Exposure Atmospheres..........................27

4.4.1. Nominal Concentrations ............................................................................27

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VOLUME 1 (continued) Page

4.4.2. Analyzed Exposure Concentrations...........................................................28

4.5. Test System, Animal Receipt, and Acclimation Period.............................28

4.6. Animal Housing (Non-Exposure Periods).................................................29

4.7. Diet, Drinking Water, and Maintenance ....................................................30

4.8. Environmental Conditions (Non-Exposure Periods) .................................30

4.9. Assignment of Animals to Treatment Groups...........................................31

4.10. Organization of Test Groups, Dosage Levels, and Treatment 

Regimen .....................................................................................................31

5. Parameters Evaluated .............................................................................34

5.1. Clinical Observations and Survival ...........................................................34

5.2. Body Weights.............................................................................................34

5.3. Food Consumption.....................................................................................35

5.4. Water Consumption ...................................................................................35

5.5. Estrous Cycles............................................................................................35

5.6. Breeding Procedures..................................................................................36

5.7. Parturition ..................................................................................................37

5.8. Spermatogenic Endpoint Evaluations........................................................37

5.9. Anatomic Pathology...................................................................................38

5.9.1. Macroscopic Examination .........................................................................38

5.9.2. Organ Weights...........................................................................................39

5.9.3. Histology and Microscopic Examinations.................................................40

5.10. F1 Litter Parameters ...................................................................................40

5.10.1. Litter Viability and Deaths.........................................................................40

5.10.2. Clinical Observations.................................................................................41

5.10.3. Body Weights.............................................................................................41

5.10.4. Sex Determination .....................................................................................41

5.10.5. Calculation of Litter Parameters................................................................42

5.10.6. Scheduled Euthanasia ................................................................................42

5.11. Data Acquisition and Analysis...................................................................42

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VOLUME 1 (continued) Page

5.11.1. Acquisition and Reporting .........................................................................42

5.11.2. Statistical Analyses....................................................................................43

6. Results.......................................................................................................45

6.1. Analyzed Exposure Concentrations...........................................................45

6.2. F0 Generation .............................................................................................45

6.2.1. Clinical Observations and Survival ...........................................................45

6.2.2. Body Weights.............................................................................................46

6.2.2.1. Males..........................................................................................................46

6.2.2.2. Females......................................................................................................47

6.2.2.2.1. Pre-Mating ................................................................................................ 47

6.2.2.2.2. Gestation ................................................................................................... 47

6.2.2.2.3. Lactation ................................................................................................... 48

6.2.3. Food Consumption.....................................................................................48

6.2.3.1. Males..........................................................................................................48

6.2.3.2. Females......................................................................................................49

6.2.3.2.1. Pre-Mating ................................................................................................ 49

6.2.3.2.2. Gestation ................................................................................................... 49

6.2.3.2.3. Lactation ................................................................................................... 50

6.2.4. Water Consumption ...................................................................................50

6.2.4.1. Males..........................................................................................................50

6.2.4.2. Females......................................................................................................50

6.2.4.2.1. Pre-Mating ................................................................................................ 50

6.2.4.2.2. Gestation ................................................................................................... 51

6.2.4.2.3. Lactation ................................................................................................... 51

6.2.5. Reproductive Performance.........................................................................52

6.2.6. Gestation Length and Parturition...............................................................53

6.2.7. Spermatogenic Endpoint Evaluations........................................................53

6.2.8. Anatomic Pathology...................................................................................54

6.2.8.1. Macroscopic Examinations........................................................................54

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VOLUME 1 (continued) Page

6.2.8.2. Organ Weights...........................................................................................54

6.2.8.3. Microscopic Examinations.........................................................................55

6.3. F1 Litter Data..............................................................................................56

6.3.1. PND 0 Litter Data and Postnatal Survival .................................................56

6.3.2. General Physical Condition .......................................................................57

6.3.3. Offspring Body Weights............................................................................57

6.3.4. Necropsies of Pups Found Dead................................................................58

7. Discussion..................................................................................................59

8. Conclusions...............................................................................................62

9. Report Review and Approval .................................................................63

10. Quality Assurance Statement..................................................................64

11. References.................................................................................................67

12. Data Retention..........................................................................................69

13. Abbreviations...........................................................................................70

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INDEX OF TABLES

VOLUME 1 (continued) Page

SUMMARY DATA - F0 GENERATION

S1. Summary of Clinical Findings (F0 Males - Detailed Physical Examinations)..........72

S2. Summary of Clinical Findings 

(F0 Males - 15 Minutes Post-Exposure - Group 5) ....................................................73

S3. Summary of Clinical Findings (F0 Males - 1 Hour Post-Exposure - Group 5).........75

S4. Summary of Clinical Findings 

(F0 Males - 1 Hour Following 6-Hour Exposure Period) ..........................................76

S5. Summary of Clinical Findings 

(F0 Females - Detailed Physical Examinations).........................................................77

S6. Summary of Clinical Findings 

(F0 Females - 15 Minutes Post-Exposure - Group 5).................................................78

S7. Summary of Clinical Findings 

(F0 Females - 1 Hour Post-Exposure - Group 5)........................................................80

S8. Summary of Clinical Findings 

(F0 Females - 1 Hour Following 6-Hour Exposure Period).......................................81

S9. Summary of Body Weights [g] (F0 Males)................................................................82

S10. Summary of Body Weight Changes [g] (F0 Males)...................................................83

S11. Summary of Body Weights [g] (F0 Females).............................................................85

S12. Summary of Body Weight Changes [g] (F0 Females)...............................................86

S13. Summary of Body Weights during Gestation [g] (F0 Females).................................87

S14. Summary of Body Weight Changes during Gestation [g] (F0 Females)...................89

S15. Summary of Body Weights during Lactation [g] (F0 Females).................................91

S16. Summary of Body Weight Changes during Lactation [g] (F0 Females)...................92

S17. Summary of Food Consumption [g/animal/day] (F0 Males).....................................93

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VOLUME 1 (continued) Page

S18. Summary of Food Consumption [g/kg/day] (F0 Males)............................................94

S19. Summary of Food Consumption [g/animal/day] (F0 Females)..................................95

S20. Summary of Food Consumption [g/kg/day] (F0 Females).........................................96

S21. Summary of Food Consumption during Gestation [g/animal/day] 

(F0 Females)................................................................................................................97

S22. Summary of Food Consumption during Gestation [g/kg/day] (F0 Females) ............99

S23. Summary of Food Consumption during Lactation [g/animal/day] 

(F0 Females)..............................................................................................................101

S24. Summary of Food Consumption during Lactation [g/kg/day] (F0 Females)...........102

S25. Summary of Water Consumption [g/animal/day] (F0 Males)..................................103

S26. Summary of Water Consumption [g/kg/day] (F0 Males).........................................104

S27. Summary of Water Consumption [g/animal/day] (F0 Females)..............................105

S28. Summary of Water Consumption [g/kg/day] (F0 Females).....................................106

S29. Summary of Water Consumption during Gestation [g/animal/day] 

(F0 Females)..............................................................................................................107

S30. Summary of Water Consumption during Gestation [g/kg/day] (F0 Females).........109

S31. Summary of Water Consumption during Lactation [g/animal/day] 

(F0 Females)..............................................................................................................111

S32. Summary of Water Consumption during Lactation [g/kg/day] (F0 Females).........112

S33. Summary of Estrous Cycle Data (F0 Females) ........................................................113

S34. Summary of Reproductive Performance (F0)...........................................................114

S35. Summary of Gestation Lengths [days] (F0 Females)...............................................117

S36. Summary of Parturition Findings: Total Occurrence/No. of Females 

(F0 Females)..............................................................................................................118

S37. Summary of Sperm Motility and Concentration (F0 Males)....................................119

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VOLUME 1 (continued) Page

S38. Summary of Sperm Morphology Differential Count [percentage] (F0 Males) .......121

S39. Summary of Macroscopic Findings (F0 Males).......................................................123

S40. Summary of Macroscopic Findings (F0 Females - Failed to Deliver).....................124

S41. Summary of Macroscopic Findings (F0 Females - Total Litter Loss).....................125

S42. Summary of Macroscopic Findings (F0 Females - Lactation Day 4) ......................126

S43. Summary of Corpora Lutea and Implantation Sites (F0 Females)...........................127

S44. Summary of Organ Weights and Relative Organ Weights (F0 Males)....................128

S45. Summary of Organ Weights and Relative Organ Weights 

(F0 Females - Lactation Day 4) ................................................................................137

S46. Summary of Microscopic Findings (F0 Males)........................................................143

S47. Summary of Microscopic Findings (F0 Females - Failed to Deliver) .....................146

S48. Summary of Microscopic Findings (F0 Females - Total Litter Loss)......................148

S49. Summary of Microscopic Findings (F0 Females - Lactation Day 4).......................150

S50. Summary of Primordial Follicle Counts (F0 Females) ............................................152

SUMMARY DATA - F1 LITTERS

S51. Summary of PND 0 Litter Data (F1)........................................................................153

S52. Summary of Postnatal Survival [% per litter] (F1)...................................................154

S53. Summary of Clinical Findings: Total Occurrence/No. of Pups (F1).......................155

S54. Summary of Offspring Weights [g] (F1)..................................................................157

S55. Summary of Offspring Weight Changes [g] (F1).....................................................158

S56. Summary of Pup Necropsy Findings (F1 - Unscheduled Deaths)...........................159

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INDEX OF APPENDICES

VOLUME 1 (continued) Page

A. Study Protocol and Deviations.................................................................................160

B. Certificate of Analysis (Sponsor-Provided Data) ....................................................200

C. Exposure Atmosphere Generation Report (WIL Research)....................................203

D. Animal Room Environmental Conditions................................................................269

E. Pathology Report (WIL Research)...........................................................................276

F. WIL Research Reproductive Historical Control Data [Crl:CD(SD) Rats]..............288

VOLUME 2

G. Individual Animal Data ............................................................................................299

F0 GENERATION

A1. Individual Clinical Observations 

 (F0 Males - Detailed Physical Examinations) ..................................................300

A2. Individual Clinical Observations 

 (F0 Males - 15 Minutes Post-Exposure - Group 5) ..........................................315

A3. Individual Clinical Observations 

 (F0 Males - 1 Hour Post-Exposure - Group 5) .................................................334

A4. Individual Clinical Observations 

 (F0 Males - 1 Hour Following 6-Hour Exposure Period) ................................347

A5. Individual Clinical Observations 

 (F0 Females - Detailed Physical Examinations)...............................................407

A6. Individual Clinical Observations 

 (F0 Females - 15 Minutes Post-Exposure - Group 5).......................................427

A7. Individual Clinical Observations 

 (F0 Females - 1 Hour Post-Exposure - Group 5)..............................................449

A8. Individual Clinical Observations 

 (F0 Females - 1 Hour Following 6-Hour Exposure Period).............................466

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VOLUME 2 (continued) Page

A9. Individual Body Weights [g] (F0 Males)..........................................................543

A10. Individual Body Weight Changes [g] (F0 Males) ..........................................548

A11. Individual Body Weights [g] (F0 Females)....................................................553

A12. Individual Body Weight Changes [g] (F0 Females).......................................558

A13. Individual Body Weights during Gestation [g] (F0 Females)........................563

A14. Individual Body Weight Changes during Gestation [g] (F0 Females)...........568

A15. Individual Body Weights during Lactation [g] (F0 Females)........................573

A16. Individual Body Weight Changes during Lactation [g] (F0 Females)...........578

A17. Individual Food Consumption [g/animal/day] (F0 Males).............................583

A18. Individual Food Consumption [g/kg/day] (F0 Males)....................................588

VOLUME 3

A19. Individual Food Consumption [g/animal/day] (F0 Females).........................595

A20. Individual Food Consumption [g/kg/day] (F0 Females)................................600

A21. Individual Food Consumption during Gestation [g/animal/day] 

 (F0 Females)....................................................................................................605

A22. Individual Food Consumption during Gestation [g/kg/day] 

 (F0 Females)....................................................................................................610

A23. Individual Food Consumption during Lactation [g/animal/day] 

 (F0 Females)....................................................................................................615

A24. Individual Food Consumption during Lactation [g/kg/day] 

 (F0 Females)....................................................................................................620

A25. Individual Water Consumption [g/animal/day] (F0 Males)...........................625

A26. Individual Water Consumption [g/kg/day] (F0 Males)..................................635

A27. Individual Water Consumption [g/animal/day] (F0 Females)........................640

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VOLUME 3 (continued) Page

A28. Individual Water Consumption [g/kg/day] (F0 Females)...............................660

A29. Individual Water Consumption during Gestation [g/animal/day] 

 (F0 Females)....................................................................................................665

A30. Individual Water Consumption during Gestation [g/kg/day] 

 (F0 Females)....................................................................................................685

A31. Individual Water Consumption during Lactation [g/animal/day] 

 (F0 Females)....................................................................................................690

A32. Individual Water Consumption during Lactation [g/kg/day] 

 (F0 Females)....................................................................................................695

A33. Individual Estrous Cycle Data (F0 Females)..................................................700

A34. Individual Reproductive Performance (F0)....................................................705

A35. Individual Gestation Lengths [days] (F0 Females).........................................710

A36. Individual Dam Observations during Parturition (F0 Females).....................711

A37. Individual Sperm Motility and Concentration (F0 Males).............................727

A38. Individual Sperm Morphology Differential Count [percentage] 

 (F0 Males) ......................................................................................................732

A39. Individual Macroscopic and Microscopic Findings (F0 Males).....................737

A40. Individual Macroscopic and Microscopic Findings 

 (F0 Females - Failed to Deliver).....................................................................799

A41. Individual Macroscopic and Microscopic Findings 

 (F0 Females - Total Litter Loss) .....................................................................800

VOLUME 4

A42. Individual Macroscopic and Microscopic Findings 

 (F0 Females - Lactation Day 4) ......................................................................803

A43. Individual Corpora Lutea and Implantation Sites (F0 Females)....................861

A44. Individual Organ Weights and Final Body Weights [g] (F0 Males)..............866

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VOLUME 4 (continued) Page

A45. Individual Organ Wts. Relative to Final Body Wts. [g/100 g] 

 (F0 Males) .......................................................................................................876

A46. Individual Organ Weights Relative to Brain Weights [g/100 g] 

 (F0 Males) .......................................................................................................886

A47. Individual Organ Weights and Final Body Weights [g] 

 (F0 Females - Lactation Day 4) ......................................................................896

A48. Individual Organ Wts. Relative to Final Body Wts. [g/100 g] 

 (F0 Females - Lactation Day 4) ......................................................................901

A49. Individual Organ Weights Relative to Brain Weights [g/100 g] 

 (F0 Females - Lactation Day 4) ......................................................................906

A50. Individual Ovarian Primordial Follicle Counts (F0 Females)........................911

F1 LITTER GENERATION

A51. Individual Litter Viability (F1) .......................................................................914

A52. Individual Pup Viability (F1)..........................................................................924

A53. Individual Postnatal Survival (% per Litter) (F1)...........................................934

A54. Individual Pup Clinical Observations (F1).....................................................939

A55. Individual Offspring Weights [g] (F1)..........................................................1018

A56. Individual Offspring Weight Changes [g] (F1) ............................................1060

A57. Individual Pup Necropsy Findings (F1 - Unscheduled Deaths)...................1100

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1. SUMMARY

1.1. OBJECTIVE

This study was designed to provide information on the potential adverse effects of the test 

substance on male and female reproduction within the scope of a screening study. This 

encompassed gonadal function, mating behavior, conception, parturition, and lactation of 

the F0 generation and the development of offspring from conception through day 4 of 

postnatal life. The test substance is currently intended for use as a fire extinguishing 

agent and a special acute exposure group was included in the study to mimic the 

maximum exposure to the test substance as discharged from a fire extinguisher in all 

known environments where clean agents are used, including aviation.

1.2. STUDY DESIGN

The test substance, 2-Bromo-3,3,3-Trifluoropropene, was administered via whole-body 

inhalation exposure for 6 hours per day to 3 groups (Groups 2-4) and for 5 minutes per 

day to 1 group (Group 5) of Crl:CD(SD) rats; animals in Group 5 were exposed to 

filtered air for the remainder of the 6-hour exposure period. Each group consisted of 

12 males and 12 females. Target exposure concentrations were 50, 100, 175, and 

10,000 ppm. A concurrent control group of 12 rats/sex was exposed to filtered air for 

6 hours per day. Males and females were approximately 10 weeks of age at the 

beginning of test substance exposure. Males were exposed to the test substance for

14 days prior to mating and throughout the mating period until 1 day prior to euthanasia 

for a total of 28-29 days of exposure. Females were exposed to the test substance for

14 days prior to pairing and throughout the mating period until gestation day 20 for a 

total of 35-46 days of exposure; females that failed to deliver were dosed through the day 

prior to euthanasia (post-cohabitation day 25) for a total of 52 days of exposure. All 

animals were observed twice daily for mortality and moribundity. Clinical observations, 

body weights, and food and water consumption were recorded at appropriate intervals. 

All F0 females were allowed to deliver and rear their pups until lactation day 4. 

F1 clinical observations and body weights were recorded on PND 1 and 4. Pups were 

euthanized on PND 4. F0 males were euthanized following completion of the mating 

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period and F0 females were euthanized on lactation day 4. Spermatogenic endpoint 

evaluations were conducted on all F0 males. Complete necropsies were conducted on all 

F0 animals, and selected organs were weighed. Selected tissues were examined 

microscopically from all F0 animals in the control, 175, and 10,000 ppm groups.

1.3. RESULTS

There were no effects on F0 parental survival at any exposure concentration. Test 

substance-related clinical findings noted at 15 minutes following exposure for males and 

females in the 10,000 ppm group included hypoactivity, decreased respiration,

completely shut eyelids, and lacrimation. However, these findings were only noted on 

the first day of exposure (study day 0) and were resolved by 1 hour following exposure. 

In addition, salivation and red and/or clear material around the mouth and/or nose were 

noted for males and females in the 10,000 ppm group throughout the respective exposure 

periods at 15 minutes and/or 1 hour following exposure. No other test substance-related 

clinical findings were noted for males or females in the 50, 100, 175, and 10,000 ppm 

groups. At the scheduled necropsy, no noteworthy macroscopic findings were noted for 

F0 males and females at any exposure concentration.

In the 10,000 ppm group F0 males, lower mean body weight gains were noted throughout 

the exposure period and resulted in a lower mean body weight on study day 28. In 

addition, corresponding lower mean food consumption was noted for the 10,000 ppm 

group males compared to the control group during the pre-mating period (study 

days 0-13). The aforementioned body weight and food consumption effects for F0 males 

were considered test substance-related and adverse within the context of a toxicology 

study. However, given that the 10,000 ppm exposure level was intended to mimic and 

assess a single maximum exposure in humans analogous to that which might occur 

during fire fighter usage, the changes noted in mean body weight gain and food 

consumption that led to a reduction in mean body weight only after 28 days of exposure 

would not be relevant to a single exposure scenario at the same exposure level. Mean 

body weights, body weight gains, and food consumption in the 10,000 ppm group 

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F0 females were generally similar to the control group during the pre-mating period, 

gestation, and lactation. In addition, mean water consumption for F0 males and females 

at 10,000 ppm was unaffected by test substance exposure.

Mean body weight gains for F0 males in the 100 and 175 ppm groups were similar to the 

control group during the pre-mating period (study days 0-13), but lower mean body 

weight gains were noted in these groups compared to the control group during study 

days 21-28. However, the aforementioned changes for F0 males at 100 and 175 ppm 

were not of sufficient magnitude to affect mean body weights in these groups, and 

therefore were considered test substance-related but nonadverse. Mean body weights and

body weight gains at 50 ppm, and mean food and water consumption at 50, 100, and 175 

ppm were similar to the control group during the exposure period. 

Mean body weights, body weight gains, and food consumption in the 50, 100, and 

175 ppm group F0 females were unaffected by test substance exposure. In addition, mean 

water consumption during the pre-mating period for F0 females in the 50, 100, and 

175 ppm groups was similar to the control group. During gestation, test 

substance-related, higher mean maternal water consumption was noted in the 175 ppm 

group F0 females compared to the control group throughout gestation and was considered 

adverse. In the 100 ppm group, higher mean water consumption was noted during 

gestation days 4-7 compared to the control group; however, mean water consumption in 

this group was similar to the control group for the remainder of gestation (gestation 

days 7-20) and when the entire gestation exposure period (gestation days 0-20) was 

evaluated. Therefore, the higher mean water consumption noted for F0 females at 

100 ppm was considered test substance-related, but nonadverse. During lactation, lower 

mean water consumption was noted for the 50, 100, and 175 ppm group F0 females 

compared to the control group. However, no corresponding effects on body weight or 

food consumption parameters were noted for F0 females in these groups during lactation; 

therefore, the lower mean water consumption noted during lactation was attributed to 

biological variation and not considered test substance-related. 

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F0 male and female mating and fertility, male copulation and female conception indices,

estrous cyclicity, and the process of parturition were unaffected by test substance

exposure at all exposure levels. No exposure-related effects were observed on 

F0 spermatogenesis endpoints (mean testicular and epididymal sperm numbers and sperm 

production rate, motility, progressive motility, and morphology) in males at any exposure 

concentration. A test substance-related, adverse, higher mean pre-coital interval and 

longer mean gestation length were noted in the 175 ppm group F0 females compared to 

the control group. Although a longer mean gestation length was also noted at 100 ppm

and considered test substance-related, the value was within the range of values in the

WIL Research historical control data, and therefore was not considered adverse. The 

mean number of days between pairing and coitus for F0 females at 50, 100, and 

10,000 ppm and mean gestation length at 50 and 10,000 ppm were similar to the control 

group values. The mean numbers of corpora lutea, implantation sites, and 

unaccounted-for sites in the test substance-exposed groups were similar to those in the 

control group.

There were no test substance-related gross pathologic changes, microscopic changes, or 

organ weight effects at any exposure concentration. There were no test substance-related 

effects on primordial/primary follicle counts in the 175 and 10,000 ppm groups.

The mean numbers of F1 pups born, the pup sex ratio, and live litter size in the 50, 100, 

175, and 10,000 ppm groups were unaffected by parental test substance exposure. In the 

100 and 175 ppm groups, test substance-related, lower postnatal survival was noted 

during PND 0-1, 1-4, and from birth to PND 4 compared to the control group; the values 

in the 175 ppm group were below the minimum mean values in the WIL Research

historical control data, and therefore were considered adverse. The postnatal survival 

values in the 100 ppm group were within the range of values in the WIL Research 

historical control data, and therefore were considered nonadverse. Postnatal survival in 

the 50 and 10,000 ppm groups was similar to the control group. No remarkable findings 

regarding the general physical condition of the F1 pups were noted at any exposure 

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concentration. No adverse effects on mean F1 male and female pup body weights and 

body weight gains were noted during PND 1-4 at 50, 100, 175, and 10,000 ppm. At the 

necropsy for F1 pups that were found dead, an increased incidence of interventricular 

septal defect was noted in the 175 ppm group and was considered test substance-related

and adverse. 

1.4. CONCLUSION

In the 10,000 ppm group, adverse clinical signs (hypoactivity, decreased respiration,

completely shut eyelids, and lacrimation) were noted for all F0 males and females on the 

first day of test substance exposure. These findings were noted at approximately

15 minutes following test substance exposure and were resolved by approximately 1 hour 

following exposure. In addition, lower mean F0 male body weights, body weight gains, 

and food consumption were noted at this exposure level; no test substance-related effects 

on body weight or food consumption parameters were noted for F0 females. The 

aforementioned body weight and food consumption effects for F0 males were considered 

test substance-related and adverse within the context of a toxicology study. However, 

given that the 10,000 ppm exposure level was intended to mimic and assess a single

maximum exposure in humans, the changes noted in mean body weight gain and food 

consumption that led to a reduction in mean body weight only after 28 days of exposure 

would not be relevant to a single exposure scenario at the same exposure level. No 

effects on F0 reproductive performance and F1 offspring were noted at 10,000 ppm when 

2-Bromo-3,3,3-Trifluoropropene was administered as a daily 5-minute whole-body

inhalation exposure.

Under the conditions of this screening study, an exposure level of 100 ppm was 

considered to be the no-observed-adverse-effect level (NOAEL) for female systemic 

toxicity, reproductive toxicity, and neonatal toxicity based on the increase in mean water 

consumption for females during gestation, longer mean pre-coital interval, longer mean 

gestation length, and the reduced postnatal survival noted in the 175 ppm group. The 

NOAEL for F0 male systemic toxicity was considered to be 175 ppm, the highest 

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exposure concentration tested, based on the lack of adverse effects on systemic toxicity

for males at any 6-hour exposure regimen or at the 10,000 ppm 5-minute exposure.

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2. INTRODUCTION

2.1. GENERAL STUDY INFORMATION

This report presents the data from “An Inhalation Reproduction/Developmental Toxicity

Screening Study of 2-Bromo-3,3,3-Trifluoropropene in Rats.” Due to software spacing 

constraints, the study title is presented as “Rat Inhal Repro/ Dev/Tox Study of 

2-Brom-3,3,3-Trifluoropropene” on the report tables. For clarification of terminology 

used to differentiate the generations in the report text, the offspring of the F0 generation 

were defined as the F1 litters. 

The study protocol and deviations from the protocol are presented in Appendix A. A list 

of abbreviations potentially used in this report is presented in Section 13.

For the data collection process, each phase of the study was separated into what were 

termed WIL Research computer protocols. The computer protocol reference numbers 

and types of data collected were identified as follows:

Computer Protocol Type of Data Collected

WIL-65501M.......................................... F0 male data

WIL-65501F........................................... F0 female data and F1 litter data

2.2. KEY STUDY DATES

Date(s) 1 Event(s)

25 September 2013................................. Study initiation date (date protocol signed 

by Study Director) 

26 September 2013.................................Experimental starting date (animal receipt)

14 October 2013 .....................................Experimental start date (initiation of F0 test 

substance exposure)

14 October - 11 November 2013............Test substance exposure (F0 males)

14 October - 04 December 2013 ............Test substance exposure (F0 females)

27 October - 10 November 2013............ F0 Mating period

12 November 2013 .................................Last F0 male necropsy

05 December 2013..................................Last F0 female necropsy

21 February 2014....................................Experimental termination/completion date 

(last skeletal examination)

 

1 Date ranges represent the first and last dates of evaluation.

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2.3. PARTICIPATING SCIENTISTS

Inhalation Exposure Analysis Arthur J. Stephens, BA

WIL Research

2.4. CONTRIBUTING SCIENTISTS AND TEST SITES

Study Pathologist and Ovarian 

Primordial Follicle Evaluation

Catherine A. Picut, VMD, DACVP, DABT

WIL Research

2.5. PRINCIPAL INVESTIGATORS AND TEST SITES

Ovarian Histology Sirena Hudgins, HT (ASCP)

WIL Research

2.6. WIL RESEARCH KEY STUDY PERSONNEL

Susan C. Haley, BS Senior Laboratory Operations Manager

Heather L. Johnson, BS, 

RQAP-GLP

Assistant Director, Quality and Regulatory

Compliance

Sally A. Keets, AS Senior Operations Manager, Central 

Scheduling

Carol A. Kopp, BS, LAT Fetal Morphologist, Manager, 

Developmental Toxicology Laboratory

Erica L. Lashley, BS, LAT Senior Animal Operations Manager

Gwendalyn M. Maginnis, DVM Attending Veterinarian

George A. Parker, DVM, PhD, 

DACVP, DABT

Vice President, Global Pathology

Theresa M. Rafeld, CPhT Night Manager, Nonclinical Operations

Andrew J. Smith, BS Group Manager, Inhalation Toxicology

Andrew M. Vick, PhD Senior Director, Analytical Services

Robert A. Wally, BS Operations Manager, Reporting & 

Technical Support Services

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3. STUDY DESIGN

Acclimation period

12 F0 animals/sex/group exposed to the test 

substance or filtered air for 6 hours daily 

(Groups 1-4) at least 14 days prior to mating. 

12 F0 animals/sex in Group 5 exposed to the 

test substance for 5 minutes and filtered air for 

the remainder of the 6-hour exposure period

daily at least 14 days prior to mating.

Clinical observations, body weights, and 

food and water consumption recorded at 

appropriate intervals

F0 animals paired to produce F1 litters

F0 males exposed to the test substance or 

filtered air daily throughout mating and through 

the day prior to necropsy. F0 females exposed 

to the test substance or filtered air daily

throughout mating and until gestation day 20 

(females with evidence of mating) or through 

the day prior to necropsy (female that failed to 

deliver)

F0 females allowed to deliver and rear their 

pups to PND 4

Necropsies 

performed on F1

pups found dead

Necropsy

performed on F0

female with total 

litter loss

F1 pup clinical observations and body weights 

recorded at appropriate intervals

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F0 adults necropsied following completion 

of the mating period (males) or on 

post-cohabitation day 25 or lactation day 4 

(females); spermatogenic endpoints evaluated 

(males); selected organs weighed; 

histopathological evaluation of selected tissues

F1 pups euthanized and discarded on PND 4

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4. EXPERIMENTAL PROCEDURES - MATERIALS AND METHODS

4.1. TEST SUBSTANCE AND CONTROL SUBSTANCE

4.1.1. TEST SUBSTANCE

The test substance, 2-Bromo-3,3,3-Trifluoropropene, was received as follows:

Identification Physical 

Description Date of Receipt Supplier

2-Bromo-3,3,3-

Trifluoropropene

Lot no. WNCC-BTP111128

Retest date: 22 October 2014

CAS no. 1514-82-5

[WIL ID no. 130241]

Pale yellow 

liquid 19 September 2013 Sponsor

2-Bromo-3,3,3-

Trifluoropropene

Lot no. WNCC-BTP111128

Retest date: 22 October 2014

CAS no. 1514-82-5

[WIL ID no. 130263]

Pale yellow 

liquid 27 September 2013 Sponsor

Documentation regarding the purity and stability of the test substance is on file with the 

Sponsor and WIL Research. A Certificate of Analysis for the test substance was 

provided by the Sponsor and is presented in Appendix B. The purity of the test substance

was >99.4%. The test substance contained small amounts of the following stabilizing 

additives: 

The test substance was stored at 

room temperature and was considered stable under this condition. A reserve sample of

each shipment of the test substance was collected and stored in the WIL Research 

Archives.

4.1.2. CONTROL SUBSTANCE

The control item used for exposure to the control group (Group 1) was filtered air.

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4.2. EXPOSURE METHODS

Exposures for Groups 1-4 were conducted in 1.0-m3stainless steel and glass whole-body

inhalation exposure chambers and exposures for Group 5 were conducted in two 0.5-m3

stainless steel and glass whole-body inhalation exposure chambers. Four chambers were 

dedicated to the control, 50, 100, and 175 ppm groups while 2 chambers were dedicated 

to Group 5 (1 chamber for test substance exposure and 1 chamber for filtered air 

exposure). All chambers were operated under dynamic conditions, at a slight negative 

pressure (ca. 0.5 in. of water) with at least 12 to 15 air changes per hour. Oxygen content 

of the exposure atmosphere was at least 19.0% and was documented during the pre-study 

methods development phase. Temperature and relative humidity during exposures were 

measured at least once every hour for each chamber and the daily average was between 

19°C and 25°C and 30% to 70%, respectively. Exposure methods and chamber 

environmental conditions are presented in Appendix C. 

All animals were housed in a normal animal colony room during non-exposure hours. 

For each day’s exposure, the animals were transferred to exposure caging, transported to 

the exposure chamber room (Exposure Room 3 for Groups 1, 2, 3, and 4 and Exposure 

Room 5 for Group 5), exposed for the requisite duration, and returned to their home 

cages. Food and water were withheld during the exposure period. Animal cage batteries 

were rotated through the various possible chamber locations on a daily basis. 

4.3. TEST ATMOSPHERE GENERATION METHODS

4.3.1. EXPOSURE CHAMBERS 2, 3, AND 4

A single vapor generator was used to produce a vapor and a distribution system was used

to deliver a controlled amount of test substance to each chamber. The single generator 

consisted of a sealable 4-neck reaction flask (1000 mL) that was filled with an 

appropriate volume of test substance and heated to 29°C to 41°C using a mantle-type 

heater (Glas-Col, LLC, Terre Haute, IN) controlled using a Powerstat variable 

transformer (model no. 3PN116C, Superior Electric, Farmington, CT). Using a regulator 

(Coilhose Pneumatics, Inc., East Brunswick, NJ) and an Omega® digital mass flowmeter 

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(model no. FMA1820), compressed nitrogen was metered to 1 port of the reaction flask. 

Two ports were used to measure both the liquid and vapor temperatures separately within 

the flask. The temperatures were monitored using separate probes and Omega®PID 

temperature controllers and process monitors (model no. CNi1654). The outlet port was

used to deliver test substance vapor to a stainless steel mixing-tee through a 3-way valve

(bypass valve). With the 3-way valve in the “EXPOSURE” position, test substance 

vapor was directed to the mixing tee where dilution air was added. Using a Coilhose 

regulator (model no. 8802K) and an Omega® digital mass flowmeter (model 

no. FMA1820), compressed air was added to the mixing tee. The test substance 

atmosphere was directed from the mixing tee to a stainless steel manifold where it was

distributed to each exposure chamber using compressed air-powered, adjustable 

transvector air pumps. 

The vapor generator, distribution manifold, bypass valve and interconnecting Teflon®or 

stainless steel tubing, and fittings were contained within a vented safety cabinet. The air 

exiting the cabinet was connected to the facility exhaust. 

Using Coilhose regulators (model no. 8802K), compressed air was supplied to each 

transvector (VDF-100, Vaccon Company, Inc., Medway, MA) to control the portion of 

test substance atmosphere pulled from the manifold. A metal orifice (O’Keefe Controls 

Co., Trumbull, CT) was placed in-line after the manifold to restrict the flow directed to 

each transvector. Test substance atmosphere was delivered to each chamber inlet via 3/8-

inch polyethylene lines. Chamber supply air was added to the chamber inlet where it 

mixed with the test substance atmosphere to produce the desired exposure concentration

prior to entering the chamber. 

A detailed description of the test atmosphere generation method is presented in 

Appendix C. 

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4.3.2. EXPOSURE CHAMBER 5B (10,000 PPM)

A single vapor generator was used to produce a vapor atmosphere. A 500-mL gas 

washing bottle, filled with an initial appropriate amount of test substance, was heated in 

an oil bath. The oil bath (Fisher Scientific Isotemp [model no. 102, Fisher Scientific, 

Waltham, MA]) was heated to between 63°C and 86°C monitored with a J-Type 

thermocouple, and controlled using an Omega®PID temperature controller and process 

monitor (model no. CNi1654) (read-out only). Using an FMI Lab pump (model no. QG 

20, Fluid Metering, Inc., Syosset, NY), additional test substance was delivered at a 

constant rate from the reservoir to the gas washing bottle. Using a Coilhose Pneumatics 

regulator (model no. 8802K) and a rotameter-type flowmeter (model no. PMR1-010649, 

Cole-Parmer, Vernon Hills, IL), compressed nitrogen was metered through a tube heater

to the inlet of the gas washing bottle. The tube heater was heated to 89°C to 114°C, 

monitored using a J-Type thermocouple, and controlled using an Omega®PID 

temperature controller and process monitor (model no. CNi1654). Nitrogen was metered 

into the inlet stem of the gas washing bottle where it passed through a fritted disk and

bubbled through the liquid test substance to produce vapors of the test substance. Test 

substance vapor from the gas washing bottle was delivered to the chamber inlet via 1⁄4-

inch polyethylene line. Chamber supply air was added to the chamber inlet where it 

mixed with the test substance vapor to produce the desired exposure concentration prior 

to entering the chamber. The vapor generator and test atmosphere exposure chamber was

contained within a vented hood. 

A detailed description of the test atmosphere generation method is presented in 

Appendix C. 

4.4. METHODS FOR CHARACTERIZATION OF EXPOSURE ATMOSPHERES

4.4.1. NOMINAL CONCENTRATIONS

Because single vapor generation was used to produce a vapor and a distribution system 

was used to deliver a controlled amount of test material to each chamber, it was not 

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possible to calculate nominal concentrations. Test substance usage was documented 

daily.

4.4.2. ANALYZED EXPOSURE CONCENTRATIONS

Analyzed exposure concentrations were determined at approximately 60-minute intervals 

using a gas chromatograph (GC) under the control of the WINH data acquisition software 

application (Groups 1, 2, 3, and 4). Test atmosphere samples were collected 

automatically using a heated external multi-position valve. For Chambers 5A and 5B, 

analytical samples were manually collected approximately hourly and twice during the 

test substance exposure, respectively, using an external multi-position valve (Model E16, 

Valco Instruments Co., Inc., Houston, TX) that permits sequential sampling from the 

exposure room and each exposure chamber. Samples were collected from the 

approximate animal-breathing zone of the inhalation exposure chambers via heated 

stainless steel sampling lines. Gas sample injection onto the chromatography column 

occurred via an internal gas-sampling valve with sample loop. For each sample, the 

chromatograph was displayed and the area under the sample peak was calculated and 

stored. The concentration in parts per million (ppm) was calculated using an ln-quadratic 

equation based on the GC calibration curve. Additional details of the methods for 

characterization of exposure atmospheres are presented in Appendix C and the results are 

summarized in Section 6.1.

4.5. TEST SYSTEM, ANIMAL RECEIPT, AND ACCLIMATION PERIOD

Sexually mature male and virgin female Sprague Dawley [Crl:CD(SD)] rats were used as 

the test system on this study. The animal model, the Crl:CD(SD) rat, is recognized as 

appropriate for reproduction studies. WIL Research has reproductive historical control 

data for the Crl:CD(SD) rat. This animal model has been proven to be susceptible to the 

effects of reproductive toxicants. The number of animals selected for this study (see 

Section 4.10.) was based on the OECD Guidelines for the Testing of Chemicals, 

Guideline 421, Reproduction/Developmental Toxicity Screening Test, 27 July 1995, 

which recommends evaluation of at least 8 pregnant females per group. Given the 

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possibility of nongravid animals, unexpected deaths, total litter losses, or 

exposure-related moribundity and/or mortality, this was an appropriate number of 

animals to obtain a sample size of 8 animals per group at termination. 

Crl:CD(SD) rats (66 males and 66 females) were received in good health from Charles 

River Laboratories, Inc., Portage, MI on 26 September 2013. The animals were

approximately 55 days old upon receipt. Each animal was examined by a qualified 

biologist on the day of receipt. The day following receipt, all animals were weighed and 

clinical observations were recorded. Each rat was uniquely identified by a Monel® metal 

ear tag displaying the animal number. The animals were housed for an acclimation 

period of 18 days prior to the first day of treatment. During the acclimation period, the 

animals were observed twice daily for mortality and general changes in appearance and 

behavior, and the testes were palpated at least once for all males.

4.6. ANIMAL HOUSING (NON-EXPOSURE PERIODS)

Following receipt and until pairing, all F0 animals were housed individually in clean, 

stainless steel wire-mesh cages suspended above cage-board. The cage-board was 

changed at least 3 times per week. The rats were paired for mating in the home cage of 

the male. The animals were paired continuously during the mating period, except during 

the exposure period. Animals were individually housed in stainless steel wire-mesh 

caging during the exposures, and then returned to their home cages in the animal colony 

room. Following positive evidence of mating, the males were housed in suspended 

wire-mesh cages until the scheduled necropsy, and the females were transferred to plastic 

maternity cages with nesting material, ground corncob bedding (Bed-O'Cobs®; The 

Andersons, Cob Products Division, Maumee, OH). The nesting material is periodically 

analyzed by the manufacturer for contaminants. No contaminants were present in the 

bedding at concentrations sufficient to interfere with the outcome of the study. The 

results of these analyses are maintained at WIL Research. The dams and their litters were 

housed in these cages until euthanasia on lactation day 4. Females with no evidence of 

mating were housed in plastic maternity cages until post-cohabitation day 25. Animals 

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were maintained in accordance with the Guide for the Care and Use of Laboratory 

Animals (National Research Council, 1996). The animal facilities at WIL Research are 

accredited by AAALAC International. Enrichment devices were provided to all animals 

as appropriate throughout the study for environmental enrichment and to aid in 

maintaining the animals’ oral health, and were sanitized weekly.

4.7. DIET, DRINKING WATER, AND MAINTENANCE

The basal diet used in this study, PMI Nutrition International, LLC Certified Rodent 

LabDiet®5002, was a certified feed with appropriate analyses performed by the 

manufacturer and provided to WIL Research. Feed lots used during the study were 

documented in the study records. Feeders were changed and sanitized once per week. 

Municipal water supplying the facility was regularly sampled for contaminants according 

to WIL Research’s SOPs. The results of the diet and water analyses are maintained at 

WIL Research. No contaminants were present in animal feed or water at concentrations 

sufficient to interfere with the objectives of this study. Reverse osmosis-purified 

(on-site) drinking water, delivered by water bottles attached to the cages, and the basal 

diet were provided ad libitum throughout the acclimation period and during the study, 

with the following exception. Feed and water were withheld during the exposure periods. 

4.8. ENVIRONMENTAL CONDITIONS (NON-EXPOSURE PERIODS)

All rats were housed throughout the acclimation period and during the study in an 

environmentally controlled room. The room temperature and relative humidity controls 

were set to maintain environmental conditions of 71°F ± 5°F (22°C ± 3°C) and

50% ± 20%, respectively. Room temperature and relative humidity data were monitored 

continuously and were scheduled for automatic collection on an hourly basis. These data

are summarized in Appendix D. Actual mean daily temperature ranged from 70.3°F to 

72.5°F (21.3°C to 22.5°C) and mean daily relative humidity ranged from 38.6% to 49.7%

during the study. Fluorescent lighting provided illumination for a 12-hour light 

(0600 hours to 1800 hours)/12-hour dark photoperiod. The light status (on or off) was

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recorded once every 15 minutes. Air handling units were set to provide a minimum of 

10 fresh air changes per hour.

4.9. ASSIGNMENT OF ANIMALS TO TREATMENT GROUPS

At the conclusion of the acclimation period, all available males and females were 

weighed and examined in detail for physical abnormalities. At the discretion of the Study

Director, each animal judged to be in good health and meeting acceptable body weight 

requirements was selected for use in the computerized randomization procedure based on 

body weight stratification in a block design. At that time, the individual body weights 

and corresponding animal identification numbers were entered into WTDMSTM. A

printout containing the animal numbers, corresponding body weights, and individual 

group assignments was generated. The animals then were arranged into groups according 

to the printout. Animals not assigned to study were transferred to the WIL Research

stock colony.

The experimental design consisted of 4 test substance-exposed groups and 1 control 

group composed of 12 rats/sex/group. At the initiation of test substance exposure (study

day 0), the males and females were approximately 10 weeks old. Male body weights 

ranged from 338 g to 413 g and female body weights ranged from 220 g to 273 g on 

study day 0. The animals were approximately 12 weeks old when paired on study

day 13; female body weights ranged from 244 g to 325 g on gestation day 0. 

4.10. ORGANIZATION OF TEST GROUPS, DOSAGE LEVELS, AND 

TREATMENT REGIMEN

The test substance or filtered air was administered via a daily 6-hour whole-body

exposure for Groups 1-4. Animals in Group 5 were administered the test substance via a 

daily 5-minute whole-body exposure and were exposed to filtered air for the remainder of 

the 6-hour exposure period. The F0 males were exposed during study day 0 through 

study day 27 or 28 (14 days prior to pairing through the mating period up to 1 day prior 

to scheduled euthanasia) for a total of 28-29 days. The F0 females were exposed during 

study days 0 through the day prior to euthanasia (14 days prior to pairing through 

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gestation day 20) for a total of 35-46 days. The female that failed to deliver was exposed

through the day prior to euthanasia (post-cohabitation day 25) for a total of 52 days. All 

animals were exposed at approximately the same time each day. 

The following table presents the study group assignment:

Group

Number Treatment

Target Exposure 

Level (ppm)

Number of 

Males

Number of 

Females

1 Filtered Air 0 12 12

2

2-Bromo-3,3,3-

Trifluoropropene 50 12 12

3

2-Bromo-3,3,3-

Trifluoropropene 100 12 12

4

2-Bromo-3,3,3-

Trifluoropropene 175 12 12

5

2-Bromo-3,3,3-

Trifluoropropene 10,000 12 12

Exposure concentrations were determined from the results of a previous reproductive

toxicity screening study (Brooker, 2013). In that study, rats were exposed to the test 

substance daily for 6 hours for 15 days prior to mating through lactation day 10 at

exposure levels of 200, 500, and 3000 ppm. Estrous cycles, pre-coital intervals, and 

gestation periods were increased in a dose-related manner and postnatal survival and litter 

sizes were decreased. A no-observed-adverse-effect level (NOAEL) could not be 

established based on the aforementioned findings. Based on these observations, the 

highest exposure level selected for the current study was 175 ppm for the 6-hour 

exposure and the lower exposure levels were selected to assess the dose-response 

relationship. The exposure level selected for the short 5-minute exposure period was

intended to mimic an actual exposure from a complete discharge of a fire extinguisher 

within the space typically encountered in an aircraft or a confined space representative 

(according to the Sponsor) of the worst case for broader industrial, commercial, and other 

applications found in fire protection. Industry guidelines for halon alternatives either 

allow a 5-minute concentration at the lowest-observed-adverse-effect level (LOAEL) for 

cardiac sensitization or 5-minute maximum concentration based on physiologically based 

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pharmacokinetic (PBPK) modeling. The cardiac sensitization LOAEL of 

2-Bromo-3,3,3-Trifluoropropene is 1% volume (Horrell, 2002). The exposure level 

tested was equivalent to the test substance obtaining a 1% concentration in the 

atmosphere of the enclosed aircraft or similar space. The potential effects on 

reproduction and development have not been tested previously for this exposure level and 

duration, which is highly conservative based on the short exposure period that would be 

expected in humans based on an actual exposure. 

The selected route of administration for this study was whole body inhalation exposure 

because the intended use of the test substance indicated that this would be a likely route 

of human exposure.

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5. PARAMETERS EVALUATED

5.1. CLINICAL OBSERVATIONS AND SURVIVAL 

All F0 rats were observed twice daily, once in the morning and once in the afternoon, for 

moribundity and mortality. Detailed physical examinations were conducted weekly. 

Each male and female was also observed for signs of toxicity approximately 1 hour 

following the 6-hour exposure period. In addition, each male and female in Group 5 was 

observed approximately 15 minutes and approximately 1 hour following the 5-minute 

exposure period. The absence or presence of findings was recorded for all animals.

Females expected to deliver were also observed twice daily during the period of expected 

parturition and at parturition for dystocia (prolonged labor, delayed labor) or other 

difficulties.

5.2. BODY WEIGHTS 

Individual F0 male body weights were recorded weekly throughout the study, beginning 

on the first day of exposure, until the scheduled euthanasia. Individual F0 female body 

weights were recorded weekly until evidence of copulation was observed. Mean weekly 

body weights and body weight changes are presented for each interval. In addition, 

cumulative mean body weight changes are presented for the pre-mating period (males 

and females) and for the entire generation (males only). Once evidence of mating was 

observed, female body weights were recorded on gestation days 0, 4, 7, 11, 14, 17, and 

20 and on lactation days 1 and 4. Mean gestation body weights and corresponding mean 

body weight changes are presented for these intervals and for the overall gestation 

interval (days 0-20); mean lactation body weight changes are presented for lactation 

days 1-4. Weekly body weights for females with no evidence of mating are presented on 

the individual report tables until necropsy. When body weights could not be determined 

for an animal during a given interval (as females enter gestation, weighing error, etc.), 

group mean values were calculated for that interval using the available data. The time 

periods when body weight values were unavailable for a given animal were left blank or 

designated as “NA” on the individual report tables.

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5.3. FOOD CONSUMPTION 

Individual food consumption was recorded on the corresponding weekly body weight 

days until pairing. Food intake was not recorded during the breeding period. Once 

evidence of mating was observed, F0 female food consumption was recorded on gestation 

days 0, 4, 7, 11, 14, 17, and 20 and on lactation days 1 and 4. Following the breeding 

period, food consumption for females with no evidence of mating was measured on a 

weekly basis until the scheduled euthanasia. Weekly food consumption for females with 

no evidence of mating is presented on the individual report tables until necropsy. Food

consumption was reported as g/animal/day and g/kg/day for the corresponding body 

weight change intervals. Calculation of the comprehensive intervals excludes all 

erroneous values such as total food spillage.

When food consumption could not be determined for an animal during a given interval 

(due to a weighing error, food spillage, etc.), group mean values were calculated for that 

interval using the available data. The time periods when food consumption values were 

unavailable for a given animal were left blank or designated as “NA” on the individual 

report tables.

5.4. WATER CONSUMPTION

Individual F0 male and female water consumption was recorded on a daily basis 

beginning on the first day of exposure until euthanasia and was reported on weekly basis. 

Water intake was not recorded during the mating period. Once evidence of mating was 

observed, F0 female water consumption was reported for the corresponding body weight 

intervals. Daily water consumption for females with no evidence of mating is presented 

on the individual report tables until necropsy. Water consumption was reported as 

g/animal/day and g/kg/day for the corresponding body weight change intervals. 

5.5. ESTROUS CYCLES 

Vaginal lavages were performed daily and the slides were evaluated microscopically to 

determine the stage of the estrous cycle of each female for 10 days prior to test substance 

administration and continuing until evidence of copulation was observed or until 

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termination of the mating period for females with no evidence of mating. The average 

cycle length was calculated and reported for complete estrous cycles (i.e., the total 

number of returns to metestrus [M] or diestrus [D] from estrus [E] or proestrus [P] until 

the detection of evidence of mating), beginning with the first day of dose administration. 

Estrous cycle length was determined by counting the number of days from the first M or 

D in a cycle to the first M or D in a subsequent cycle. The cycle during which evidence 

of mating was observed for a given animal was not included in the mean individual 

estrous cycle length calculation.

5.6. BREEDING PROCEDURES 

The animals were paired on a 1:1 basis within each treatment group following 14 days of 

exposure for the males and females. A breeding record containing the male and female 

identification numbers and the start date of cohabitation was maintained. Each female 

was housed in the home cage of the male during cohabitation. Positive evidence of 

mating was confirmed by the presence of a vaginal copulatory plug or the presence of 

sperm following a vaginal lavage and verified by a second biologist. Each mating pair 

was examined daily. The day when evidence of mating was identified was termed 

gestation day 0. If evidence of copulation was not detected after 14 days of pairing, any 

females that had not shown evidence of mating were placed in plastic maternity cages.

For the purpose of calculating pre-coital intervals, rats paired over a 12-hour dark cycle 

were considered to have been paired for 1 day.

Mating, fertility, and copulation/conception indices were calculated as follows:

Male (Female)

Mating Index (%) =

No. of Males (Females) with

Evidence of Mating (or Confirmed Pregnant)

x 100 Total No. of Males (Females) Used for Mating

Male Fertility

Index (%) =

No. of Males Siring a Litter x 100 Total No. of Males Used for Mating

Male Copulation 

Index (%) =

No. of Males Siring a Litter

x 100 No. of Males with Evidence of Mating 

(or Females with Confirmed Pregnancy)

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Female Fertility

Index (%) =

No. of Females with Confirmed Pregnancy x 100 Total No. of Females Used for Mating

Female Conception 

Index (%) =

No. of Females with Confirmed Pregnancy x 100 No. of Females with Evidence of Mating (or 

Confirmed Pregnancy)

5.7. PARTURITION 

All females were allowed to deliver naturally and rear their young to PND 4. During the 

period of expected parturition, the females were observed twice daily for initiation and 

completion of parturition and for signs of dystocia. On the day parturition was initiated 

(PND 0), pups were sexed and examined for gross malformations, and the numbers of 

stillborn and live pups were recorded. Individual gestation length was calculated using 

the date delivery started.

5.8. SPERMATOGENIC ENDPOINT EVALUATIONS 

Immediately upon euthanasia, the reproductive tract of each F0 male was exposed via a 

ventral mid-line incision. The right epididymis was excised and weighed. An incision 

was made in the distal region of the right cauda epididymis. The right cauda epididymis 

was then placed in Dulbecco's phosphate-buffered saline (maintained at approximately 

37°C) with 10 mg/mL BSA. After a minimum 10-minute incubation period, a sample of 

sperm was loaded onto a slide with a 100-μm chamber depth for determination of sperm 

motility. Because sperm motility can be affected by temperature shock, all pipettes, 

slides, and diluents were warmed in an incubator, and motility determinations were 

performed under constant temperature (approximately 37°C). Analysis of a minimum of 

200 motile and nonmotile spermatozoa per animal (if possible) in all groups was 

performed by the analyzer. The motility score (percent) for motile (showing motion 

only) and progressively motile (showing net forward motion) sperm was reported:

Percent Motile (or Progressively 

Motile) Sperm =

Number of Motile (or Progressively Motile) Sperm x 100 Total Number of Sperm Counted

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The right testis and epididymis were then placed in modified Davidson’s solution for 

subsequent microscopic examination. Sperm morphology was evaluated by light 

microscopy via a modification of the wet-mount evaluation technique (Linder et al., 

1992). Abnormal forms of sperm (double heads, double tails, microcephalic or 

megacephalic, etc.) from a differential count of 200 spermatozoa per animal, if possible, 

were recorded.

The left testis and cauda epididymis from each male were weighed, stored frozen, 

homogenized, and analyzed for determination of homogenization-resistant spermatid 

count and calculation of sperm production rate (Blazak et al., 1985). An aliquot of each 

sample was added to a solution containing a DNA-specific fluorescent dye (the dye stains 

DNA that is present in the head of the sperm). For analysis, each sample was mixed, and 

an aliquot was placed on a slide with a 20-μm chamber depth. Illumination from a xenon 

lamp within the analyzer allowed for the visualization and quantitation of the sperm. A

minimum of 200 cells, if possible, or up to 20 fields were counted for each sample. The 

sperm production rate was calculated as follows:

Sperm Production Rate = No. of Sperm Per Gram of Tissue

6.1 Days

6.1 Days = The rate of turnover of the germinal epithelium

5.9. ANATOMIC PATHOLOGY

5.9.1. MACROSCOPIC EXAMINATION

A complete necropsy was conducted on all F0 parental animals at the scheduled 

termination. All F0 adults were euthanized by carbon dioxide inhalation. Males were 

euthanized following completion of the mating period. Females that delivered were 

euthanized on lactation day 4; the number of former implantation sites and corpora lutea 

were recorded. The female that failed to deliver was euthanized on post-cohabitation 

day 25. Uteri with no macroscopic evidence of implantation were opened and 

subsequently placed in 10% ammonium sulfide solution for detection of early 

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implantation loss (Salewski, 1964). The female with total litter loss was euthanized 

within 24 hours of litter loss. Necropsy included examination of the external surface, all 

orifices, the external surface of the brain, and the cranial, thoracic, abdominal, and pelvic 

cavities, including viscera. Clinical findings that were verified at necropsy were 

designated CEO (correlates with externally observed). At the time of necropsy, the 

following tissues and organs were placed in 10% neutral-buffered formalin (except as 

noted):

Brain Pituitary gland

Coagulating glands Prostate gland

Kidneys Seminal vesicles (2)

Liver (sections of 2 lobes) Spleen

Lungs Testes with epididymides (2)band vas deferens 

Mammary glands (females only) Uterusc with cervix and vagina

Ovariesaand oviducts (2) All gross lesionsd

a 

= Ovaries were fixed in 10% neutral-buffered formalin for approximately 

48 hours following which all ovaries were transferred to 70% ethanol.

b 

= Testis (right) and epididymis (right and remainder of left) were placed in 

modified Davidson’s solution; care was taken to ensure separation between the 

left and right organs.

c

= Any uterus stained in 10% ammonium sulfide solution for detection of 

implantation sites was discarded and not preserved in 10% neutral-buffered 

formalin.

d

= Representative sections of corresponding organs from a sufficient number of 

control animals were retained for comparison, if possible.

5.9.2. ORGAN WEIGHTS

The following organs were weighed from all F0 animals at the scheduled necropsies: 

Brain Lungs

Epididymides (total and caudal)a Ovaries (without oviducts)

Kidneys Pituitary gland

Liver Spleen

Testesa

a

= These paired organs were weighed separately; care was taken to ensure

 separation between the left and right organs.

Except as noted, paired organs were weighed together. Absolute weights and organ to 

final body weight and organ to brain weight ratios were reported. 

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5.9.3. HISTOLOGY AND MICROSCOPIC EXAMINATIONS

Microscopic evaluations were performed on the following tissues for all F0 parental 

animals from the control, 175, and 10,000 ppm groups.

Cervix

Coagulating gland

Epididymidesa

Lungs

Mammary glands (female only)

Ovariesb

Pituitary gland

Prostate gland

Seminal vesicles

Spleen

Testisa

Uterus

Vagina

Vas deferens

All gross (internal) lesions (all groups)

a

= Transverse sections of 2-4 microns of the testes and longitudinal sections of the 

epididymides were stained in PAS and hematoxylin in addition to routine 

hematoxylin and eosin staining.

b

= All ovaries were paraffin embedded. Five sections were taken approximately

100 μm apart from the inner third of each ovary from all of the F0 females in the 

control, 175, and 10,000 ppm groups at the scheduled necropsy and for any females 

suspected of reduced fertility. In addition, a single section was taken for a 

qualitative bilateral evaluation of each ovary. A quantitative histopathologic 

evaluation of multiple sections was conducted. This examination included 

enumeration of the total number of primordial follicles according to the methods of 

Bolon et al. (1997), Bucci et al. (1997), and Picut et al. (2008).

After fixation, protocol-specified tissues were shipped to WIL Research Hillsborough for

processing. The tissues were trimmed according to the WIL Research Hillsborough

SOPs and the protocol. Trimmed tissues were processed into paraffin blocks, sectioned 

according to WIL Research’s SOPs, mounted on glass microscope slides, and stained 

with hematoxylin and eosin.

The pathology report is presented in Appendix E. 

5.10. F1 LITTER PARAMETERS 

5.10.1. LITTER VIABILITY AND DEATHS

Each litter was examined daily for survival, and all deaths were recorded. All pups were 

individually identified by application of tattoo markings on the digits following 

completion of parturition. A daily record of litter size was maintained. Intact offspring 

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that were found dead were necropsied using a fresh dissection technique, which included 

examination of the heart and major vessels (Stuckhardt and Poppe, 1984). Pups with 

suspected skeletal anomalies were eviscerated and stained (Dawson, 1926) for 

subsequent skeletal evaluation. Findings were recorded as either developmental 

variations (alterations in anatomic structure that are considered to have no significant 

biological effect on animal health or body conformity and/or occur at high incidence, 

representing slight deviations from normal) or malformations (those structural anomalies 

that alter general body conformity, disrupt, or interfere with normal body function, or 

may be incompatible with life) as appropriate. Specimens with malformations were 

preserved in 10% neutral-buffered formalin for possible future histopathologic 

examination. The carcass of each pup was then discarded. 

5.10.2. CLINICAL OBSERVATIONS

Litters were examined daily for survival and any adverse changes in appearance or 

behavior. Each pup received a detailed physical examination on PND 1 and 4. Any 

abnormalities in nesting and nursing behavior were recorded.

5.10.3. BODY WEIGHTS

Pups were individually weighed on PND 1 and 4. Mean pup weights were presented by

sex for each litter and by dose group. When body weights could not be determined for a 

pup during a given interval (due to an unscheduled death, weighing error, etc.), group 

mean values were calculated for that interval using the available data. The time periods a 

given pup was not weighed were left blank or designated as “NA” on the individual 

report tables.

5.10.4. SEX DETERMINATION

Pups were individually sexed on PND 0 and 4.

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5.10.5. CALCULATION OF LITTER PARAMETERS

Litter parameters were defined as follows:

Mean Live Litter Size =

Total No. of Viable Pups on PND 0

No. of Litters with Viable Pups PND 0

Postnatal Survival Between Birth and 

PND 0 or PND 4

(% Per Litter)

=

Sum of (Viable Pups Per Litter on PND 0 or 

PND 4/No. of Pups Born Per Litter)

No. of Litters Per Group

x 100

Postnatal Survival for All

Other Intervals (% Per Litter) =

Sum of (Viable Pups Per Litter

at End of Interval N/Viable Pups

Per Litter at Start of Interval N)

No. of Litters Per Group

x 100

Where N = PND 0-1 and 1-4 

Total litter loss was determined when the last pup in the litter was found dead prior to the 

scheduled euthanasia.

5.10.6. SCHEDULED EUTHANASIA

On PND 4, surviving F1 rats were euthanized via an intraperitoneal injection of sodium 

pentobarbital and discarded without examination.

5.11. DATA ACQUISITION AND ANALYSIS

5.11.1. ACQUISITION AND REPORTING

Program/System Description

Archive Management System (AMS) In-house developed application for storage, 

maintenance, and retrieval of information for 

archived materials (e.g., lab books, study data, wet 

tissues, slides, etc.) 

Hamilton-Thorne Integrated Visual 

Optical System (IVOS) Sperm 

Analyzer

Optical computer combination unit (Hamilton 

Thorne Research) designed to analyze the motion, 

concentration, and fluorescent behavior of sperm 

from experimental animals.

Inhalation Exposure Data Collection 

System (WINH)

Monitors and records inhalation chamber 

temperature, relative humidity, ventilation rate, 

and negative pressure

InSight®

Publisher Electronic publishing system (output is Adobe 

Acrobat, PDF)

Master Schedule Maintains the master schedule for the company. 

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Program/System Description

Metasys DDC Electronic 

Environmental Control System

Controls and monitors animal room 

environmental conditions.

Microsoft® Office 2007 Used in conjunction with the publishing software 

to generate study reports.

WIL Metasys In-house developed system used to record and 

report animal room environmental conditions. 

WIL Toxicology Data Management 

SystemTM (WTDMSTM) 

In-house developed system used for collection and 

reporting of in-life and postmortem data.

Note: Version numbers of WTDMSTM programs used for the study are presented on the 

report data tables (reporting programs); version numbers and release dates are otherwise 

maintained in the study records and/or facility records.

5.11.2. STATISTICAL ANALYSES

All statistical tests were performed using WTDMSTM unless otherwise noted. Analyses 

were conducted using two-tailed tests (except as noted otherwise) for minimum 

significance levels of 1% and 5%, comparing each test substance-exposed group to the 

control group by sex. Each mean was presented with the standard deviation (S.D.), 

standard error (S.E.), and the number of animals (N) used to calculate the mean. Due to 

the use of significant figures and the different rounding conventions inherent in the types 

of software used, the means, standard deviations, and standard errors on the summary and 

individual tables may differ slightly. Therefore, the use of reported individual values to 

calculate subsequent parameters or means will, in some instances, yield minor variations 

from those listed in the report data tables. Data obtained from nongravid females were 

excluded from statistical analyses following the mating period. Where applicable, the 

litter was used as the experimental unit. 

Parental mating, fertility, conception, and copulation indices were analyzed using the 

Chi-square test with Yates’ correction factor (Hollander and Wolfe, 1999). Parental body

weights (weekly, gestation, and lactation), body weight changes, and food and water

consumption, offspring body weights and body weight changes, gestation length, estrous 

cycle length, numbers of former implantation sites and corpora lutea, number of pups 

born, live litter size on PND 0, unaccounted-for sites, absolute and relative organ 

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weights, pre-coital intervals, sperm production rates, epididymal and testicular sperm 

numbers, and ovarian primordial follicle counts were subjected to a parametric one-way

ANOVA (Snedecor and Cochran, 1980) to determine intergroup differences. If the 

ANOVA revealed significant (p<0.05) intergroup variance, Dunnett's test (Dunnett, 

1964) was used to compare the test substance-exposed groups to the control group. Mean 

litter proportions (percent per litter) of males at birth and postnatal survival, percentages of 

motile and progressively motile sperm, and percentages of sperm with normal 

morphology were subjected to the Kruskal-Wallis nonparametric ANOVA (Kruskal and 

Wallis, 1952) to determine intergroup differences. If the nonparametric ANOVA 

revealed significant (p<0.05) intergroup variance, Dunn’s test (Dunn, 1964) was used to 

compare the test substance-exposed groups to the control group. Histopathological 

findings in the test substance-exposed groups were compared to the control group using a 

two-tailed Fisher’s Exact test (Steel and Torrie, 1980).

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6. RESULTS 

6.1. ANALYZED EXPOSURE CONCENTRATIONS

Exposure Atmosphere Generation Report: Appendix C

Daily mean test atmosphere concentrations for each exposure are presented in 

Appendix C. The overall mean analyzed concentrations are presented in the following 

table.

Text Table 1. Overall Mean Exposure Concentrations

Exposure Chamber: 1 2 3 4 5A 5B*

Target Concentration 

(ppm): 0 50 100 175 0 10,000

Mean Concentration

(ppm): 0 50 101 174 0 10,076

Standard Deviation: 0.0 3.2 4.8 10.7 0.0 607.9

N: 38 39 40 52 38 38

* = Mean obtained from T=4 minutes and T=9 minutes; the animals were present in the

 exposure chambers for 4 minutes prior to the first concentration sampling.

6.2. F0 GENERATION

6.2.1. CLINICAL OBSERVATIONS AND SURVIVAL

Summary Data: Table S1, Table S2, Table S3, Table S4, Table S5, Table S6, Table S7,

 Table S8

Individual Data: Table A1, Table A2, Table A3, Table A4, Table A5, Table A6,

 Table A7, Table A8

All males and females in the control, 50, 100, 175, and 10,000 ppm groups survived to 

the scheduled necropsies. One female (no. 91654) in the 175 ppm group had total litter 

loss on lactation day 2 and was subsequently euthanized. 

In the 10,000 ppm group, test substance-related clinical findings of hypoactivity, 

decreased respiration, completely shut eyelids, and lacrimation were noted for all males 

and females at 15 minutes following test substance exposure on the first day of exposure 

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(study day 0). These findings did not persist to 1 hour following exposure and were only 

noted on study day 0. Salivation and red and/or clear material around the mouth and/or 

nose were noted for males and females in the 10,000 ppm group throughout the 

respective exposure periods at approximately 15 minutes and/or 1 hour following 

exposure and were considered test substance-related. 

No other test substance-related clinical findings were noted at any exposure level at the 

weekly detailed physical examinations or 1 hour following the 6-hour exposure period. 

Red material around the nose was noted for males and females in all groups, including 

the control group, at 1 hour following the 6-hour exposure period generally throughout 

the respective exposure periods. Other clinical findings noted in the test 

substance-exposed groups, including hair loss on various body surfaces, occurred 

infrequently, at similar frequencies in the control group, and/or in a manner that was not 

exposure-related.

6.2.2. BODY WEIGHTS

6.2.2.1. MALES

Summary Data: Table S9, Table S10

Individual Data: Table A9, Table A10

In the 10,000 ppm group, lower mean body weight gains were noted throughout the 

exposure period compared to the control group and resulted in lower mean body weight 

gains when the pre-mating period (study days 0-13) and the entire exposure period (study 

days 0-28) were evaluated; differences were generally significant (p<0.05 or p<0.01). In

addition, mean body weights were 6.7% lower than the control group on study day 28; 

the difference was significant (p<0.05). The aforementioned changes were considered 

test substance-related and adverse within the context of a toxicology study. However, 

given that the 10,000 ppm exposure level was intended to mimic and assess a single

maximum exposure in humans, the changes noted in mean body weight gain that led to a 

reduction in mean body weight only after 28 days of exposure would not be relevant to a 

single exposure scenario at the same exposure level.

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Mean body weight gains for males in the 100 and 175 ppm groups were similar to the 

control group during study days 0-21 and when the pre-mating period (study days 0-13) 

was evaluated. Lower mean body weight gains were noted in these groups compared to 

the control group during study days 21-28 and resulted in slightly lower mean body 

weight gains in the 100 and 175 ppm groups when the entire exposure period (study 

days 0-28) was evaluated; the differences were generally significant (p<0.05), but were 

not dose-responsive. The changes in mean body weight gain noted in the 100 and 

175 ppm groups during the latter half of the exposure period were not of sufficient 

magnitude to affect mean body weights in these groups, and therefore were considered

likely test substance-related but non-adverse. 

Mean body weights and body weight gains in the 50 ppm group males were unaffected 

by test substance exposure throughout the study. None of the differences from the 

control group were statistically significant.

6.2.2.2. FEMALES

6.2.2.2.1. PRE-MATING

Summary Data: Table S11, Table S12

Individual Data: Table A11, Table A12

Mean body weights and body weight gains in the 50, 100, 175, and 10,000 ppm group 

females were unaffected by test substance exposure during the pre-mating period (study 

days 0-13). None of the differences from the control group were statistically significant.

6.2.2.2.2. GESTATION

Summary Data: Table S13, Table S14

Individual Data: Table A13, Table A14

Mean body weights and body weight gains in the 50, 100, 175, and 10,000 ppm groups 

were unaffected by test substance exposure during gestation. None of the differences 

from the control group were statistically significant, with the following exceptions. 

Significantly (p<0.05 or p<0.01) lower mean body weight gains were noted in the 

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175 ppm group during gestation days 0-4 and 11-14 and in the 10,000 ppm group during 

gestation days 11-14. These differences were transient and not of sufficient magnitude to 

affect the overall gestation exposure period (gestation days 0-20) or mean body weights 

in these groups, and therefore were not considered test substance-related.

6.2.2.2.3. LACTATION

Summary Data: Table S15, Table S16

Individual Data: Table A15, Table A16

Mean body weights and body weight gains in the 50, 100, 175, and 10,000 ppm groups 

were unaffected by test substance exposure during lactation. None of the differences 

from the control group were statistically significant.

6.2.3. FOOD CONSUMPTION

6.2.3.1. MALES

Summary Data: Table S17, Table S18

Individual Data: Table A17, Table A18

Mean food consumption, evaluated as g/animal/day and g/kg/day, in the 10,000 ppm 

group was lower throughout the pre-mating period (study days 0-13) compared to the 

control group; differences were generally significant (p<0.05 or p<0.01). The lower 

mean food consumption noted in this group corresponded with the lower mean body 

weight gains noted during the pre-mating period in this group. The aforementioned 

changes were considered test substance-related and adverse within the context of a 

toxicology study. However, given that the 10,000 ppm exposure level was used to mimic 

and assess a single maximum exposure in humans, the changes noted in mean food 

consumption following 13 days of exposure would not be relevant to a single exposure 

scenario at the same exposure level.

Mean food consumption in the 50, 100, and 175 ppm group males was similar to that in 

the control group during the pre-mating period (study days 0-13). Differences from the 

control group were slight and not statistically significant, with the following exception:

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Significantly (p<0.05) lower mean g/kg/day food consumption was noted in the 100 ppm 

group compared to the control group during study days 7-13. There was no effect on 

g/animal/day food consumption or mean body weights in this group and this slight

difference did not occur in an exposure-related manner. Therefore, the lower mean food 

consumption noted in the 100 ppm group was not considered test substance-related.

6.2.3.2. FEMALES

6.2.3.2.1. PRE-MATING

Summary Data: Table S19, Table S20

Individual Data: Table A19, Table A20

Mean food consumption, evaluated as g/animal/day and g/kg/day, in the 50, 100, 175, 

and 10,000 ppm group females was unaffected by test substance exposure during the 

pre-mating period (study days 0-13). Differences from the control group were slight and 

not statistically significant, with the following exceptions: Significantly (p<0.05 or 

p<0.01) lower mean food consumption was noted in the 175 and 10,000 ppm groups 

compared to the control group during study days 0-7. However, these differences were

transient and not of sufficient magnitude to affect mean body weights in these groups and

were not considered test substance-related. 

6.2.3.2.2. GESTATION

Summary Data: Table S21, Table S22

Individual Data: Table A21, Table A22

Mean maternal food consumption, evaluated as g/animal/day and g/kg/day, in the 50, 

100, 175, and 10,000 ppm groups was unaffected by test substance exposure during 

gestation. Differences from the control group were slight and not statistically significant, 

with the following exception: Significantly (p<0.05 or p<0.01) lower mean food 

consumption was noted in the 175 ppm group compared to the control group during 

gestation days 0-4. This difference was not of sufficient magnitude to affect the overall 

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gestation exposure period (gestation days 0-20) or mean body weights in this group; 

therefore, it was not considered test substance-related. 

6.2.3.2.3. LACTATION

Summary Data: Table S23, Table S24

Individual Data: Table A23, Table A24

Mean maternal food consumption, evaluated as g/animal/day and g/kg/day, in the 50, 

100, 175, and 10,000 ppm groups was unaffected by test substance exposure during 

lactation. None of the differences from the control group were statistically significant.

6.2.4. WATER CONSUMPTION

6.2.4.1. MALES

Summary Data: Table S25, Table S26

Individual Data: Table A25, Table A26

Mean water consumption, evaluated as g/animal/day and g/kg/day, in the 50, 100, 175, 

and 10,000 ppm group males was similar to that in the control group throughout the 

pre-mating period (study days 0-13). No statistically significant differences were 

observed.

6.2.4.2. FEMALES

6.2.4.2.1. PRE-MATING

Summary Data: Table S27, Table S28

Individual Data: Table A27, Table A28

Mean water consumption, evaluated as g/animal/day and g/kg/day, in the 50, 100, 175, 

and 10,000 ppm group females was unaffected by test substance exposure during the 

pre-mating period (study days 0-13). None of the differences from the control group 

were statistically significant.

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6.2.4.2.2. GESTATION

Summary Data: Table S29, Table S30

Individual Data: Table A29, Table A30

Test substance-related, higher mean maternal water consumption, evaluated as 

g/animal/day and g/kg/day, was noted in the 175 ppm group compared to the control 

group generally throughout the gestation exposure period and resulted in higher mean 

water consumption in this group when the entire gestation exposure period (gestation 

days 0-20) was evaluated; differences were generally significant (p<0.01) and were 

considered adverse. In the 100 ppm group, mean water consumption was similar to the 

control group during gestation days 0-4. During gestation days 4-7, significantly 

(p<0.01) higher mean water consumption was noted in the 100 ppm group compared to 

the control group and was considered test substance-related. However, mean water 

consumption was similar to the control group or only slightly higher (not statistically

significant) for the remainder of the gestation exposure period (gestation days 7-20) and 

when the entire gestation exposure period (gestation days 0-20) was evaluated. 

Therefore, the higher mean water consumption at 100 ppm during gestation days 4-7 was 

considered likely test substance-related, but nonadverse.

Mean maternal water consumption in the 50 and 10,000 ppm groups was unaffected by 

test substance exposure during gestation. None of the differences from the control group 

were statistically significant.

6.2.4.2.3. LACTATION

Summary Data: Table S31, Table S32

Individual Data: Table A31, Table A32

Mean maternal water consumption, evaluated as g/animal/day and g/kg/day, in the 50, 

100, 175, and 10,000 ppm groups was unaffected by test substance exposure during 

lactation. Lower mean maternal water consumption was noted in the 50, 100, and 

175 ppm groups during lactation days 1-4 compared to the control group; differences

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were generally significant (p<0.05 or p<0.01). However, mean body weights, body 

weight gains, and food consumption were unaffected during lactation at these exposure 

levels. Therefore, the lower mean water consumption noted at 50, 100, and 175 ppm was 

attributed to biological variation and not considered test substance-related. 

6.2.5. REPRODUCTIVE PERFORMANCE

Summary Data: Table S33, Table S34

Individual Data: Table A33, Table A34

Historical Control Data: Appendix F

F0 male and female reproductive parameters are presented in the following table.

Text Table 2. Results of Reproductive Performance

Dosage Level (ppm) WIL HCa

Parameter 0 50 100 175 10,000 Mean (Range)

Male Mating Index 100.0 100.0 100.0 91.7 100.0 95.5 (86.7-100.0)

Female Mating Index 100.0 100.0 100.0 91.7 100.0 96.3 (86.7-100.0)

Male Fertility Index 100.0 100.0 100.0 91.7 100.0 87.5 (70.0-100.0)

Female Fertility Index 100.0 100.0 100.0 91.7 100.0 88.0 (70.0-100.0)

Male Copulation Index 100.0 100.0 100.0 100.0 100.0 92.4 (70.0-100.0)

Female Conception Index 100.0 100.0 100.0 100.0 100.0 92.3 (70.0-100.0)

Estrous Cycle Length (days) 5.2 4.6 4.9 5.0 5.1 4.5 (4.0-5.8)

Pre-Coital Interval (days) 2.9 2.9 2.4 4.5 2.0 3.0 (1.8-4.7)

a

= WIL historical control data

No exposure-related effects on male and female reproductive indices were observed at 

any exposure concentration. No statistically significant differences were noted between 

the control and test substance-exposed groups. With the exception of 1 male in the 

175 ppm group, all males sired a litter. 

A higher (not statistically significant) mean pre-coital interval was noted in the 175 ppm 

group compared to the control group; 4 of the 11 pairs of mated animals in this group had 

pre-coital intervals greater than 5 days in length. Therefore, the higher pre-coital interval 

in the 175 ppm group was considered test substance-related and adverse.

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The mean numbers of days between pairing and coitus in the 50, 100, and 10,000 ppm 

groups were similar to the control group value. The mean lengths of estrous cycles in all 

test substance-exposed groups were similar to the control group value. None of these 

differences were statistically significant.

6.2.6. GESTATION LENGTH AND PARTURITION

Summary Data: Table S35, Table S36

Individual Data: Table A35, Table A36

Historical Control Data: Appendix F

Test substance-related, significantly (p<0.01) longer mean gestation lengths were noted 

in the 100 (22.3 days) and 175 ppm (22.6 days) groups compared to the control group 

(21.7 days). Although there were no signs of dystocia at any exposure level in the study, 

the gestation length in the 175 ppm group exceeded the maximum mean value in the WIL

Research historical control data (22.3 days) and 7 of the 11 females that delivered had a 

gestation length of 23 days versus 0 of 12 females in the control group; therefore, this

change was considered adverse. The mean gestation length at 100 ppm, although 

statistically significantly increased, was within the range of values in the WIL Research

historical control data (21.5-22.3 days), and therefore was considered nonadverse.

Mean gestation lengths in the 50 and 10,000 ppm groups were similar to those in the 

control group. No statistically significant differences were noted. 

6.2.7. SPERMATOGENIC ENDPOINT EVALUATIONS

Summary Data: Table S37, Table S38

Individual Data: Table A37, Table A38

Historical Control Data: Appendix F

No exposure-related effects were observed on F0 spermatogenesis endpoints (mean 

testicular and epididymal sperm numbers and sperm production rate, motility, progressive 

motility, and morphology) in males at any exposure concentration. Differences from the 

control group were slight and were not statistically significant.

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6.2.8. ANATOMIC PATHOLOGY

6.2.8.1. MACROSCOPIC EXAMINATIONS

Summary Data: Table S39, Table S40, Table S41, Table S42, Table S43

Individual Data: Table A39, Table A40, Table A41, Table A42, Table A43

Pathology Report: Appendix E

All F0 males and females survived to the scheduled necropsies. No test substance-related

internal findings were observed at any exposure level in the female that failed to deliver, 

the female with total litter loss, or males and females at the scheduled necropsy. 

Macroscopic findings observed in the test substance-exposed groups occurred 

infrequently in single animals and/or in a manner that was not dose-related.

The mean numbers of corpora lutea, unaccounted-for sites, and implantation sites in the 

50, 100, 175, and 10,000 ppm groups were similar to the control group values. 

6.2.8.2. ORGAN WEIGHTS

Summary Data: Table S44, Table S45

Individual Data: Table A44, Table A45, Table A46, Table A47, Table A48, Table A49

Pathology Report: Appendix E

There was a test substance-related lower (7.1%, p<0.05) final body weight in the 

10,000 ppm group males. There were no test substance-related alterations in organ 

weights.

Some organ weight differences were statistically significant when compared to the 

control group, however, these changes were considered secondary to the test 

substance-related effect on final body weight. There was a significantly (p<0.01) higher 

left epididymis weight relative to final body weight in the 10,000 ppm group males. 

Since the change did not correlate to histologic findings and the mean absolute weight 

was not affected, the change was considered to be due to the lower mean final body 

weight. There was a significantly (p<0.01) higher right testis weight relative to body 

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weight in the 10,000 ppm group males. This change was also a result of a low mean final 

body weight in this dose group, and was not test substance-related.

Some statistically significant differences were observed when the control and test 

substance-treated groups were compared, but the changes were not considered test 

substance-related. There was a significantly (p<0.01) higher mean lung weight relative to 

body weight and a significantly (p<0.01) higher mean lung weight relative to brain 

weight in the 175 ppm group males compared to the control group. Because the mean 

absolute lung weight was not affected, the relative weights were within the WIL Research

historical control data ranges, and there were no histopathologic correlates, the changes in 

relative weights were not considered toxicologically significant. There were significantly

(p<0.05 or p<0.01) lower pituitary weights (absolute and relative) in 100, 175, and/or

10,000 ppm group males and females; however, because the changes did not follow a 

dose-response profile, were within the WIL Research historical control range, and did not 

correlate to histologic findings at 175 or 10,000 ppm, the statistically significant changes 

were considered spurious.

6.2.8.3. MICROSCOPIC EXAMINATIONS

Summary Data: Table S46, Table S47, Table S48, Table S49, Table S50

Individual Data: Table A39, Table A40, Table A41, Table A42, Table A50

Pathology Report: Appendix E

There were no test substance-related microscopic findings. All histologic changes were 

considered to be incidental findings or related to some aspect of experimental 

manipulation other than administration of the test substance. There was no test 

substance-related alteration in the prevalence, severity, or histologic character of those 

incidental tissue alterations.

There was no apparent test substance-related effect on the counts of primordial and 

primary follicles from ovaries in the control, 175, and 10,000 ppm group females.

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6.3. F1 LITTER DATA

6.3.1. PND 0 LITTER DATA AND POSTNATAL SURVIVAL

Summary Data: Table S51, Table S52

Individual Data: Table A51, Table A52, Table A53

Historical Control Data: Appendix F

The mean number of pups born, live litter size, and the percentage of males at birth in the 

50, 100, 175, and 10,000 ppm groups were similar to the control group values. 

Postnatal survival on PND 0 (relative to number born) in all test substance-exposed 

groups was similar to the control group. Test substance-related, lower (not statistically

significant) postnatal survival was noted in the 100 and 175 ppm groups compared to the

concurrent control group during PND 0-1, 1-4, and from birth to PND 4; the values in the 

175 ppm group were below the minimum mean values in the WIL Research historical 

control data, and 1 female in this group (no. 91654) had a total litter loss on PND 2. 

Therefore, the postnatal survival at this exposure level was considered adverse. The 

postnatal survival values in the 100 ppm group were within the range of values in the 

WIL Research historical control data, and therefore were considered within normal limits 

and not adverse. Postnatal survival values for all groups are presented in the following 

table.

Text Table 3. Summary of Postnatal Survival (% per litter)

Dosage Level (ppm) WIL HCa

Parameter 0 50 100 175 10,000 Mean (Range)

PND 0 (relative to number born) 96.5 98.0 95.2 95.4 97.0 98.0 (93.3-100.0)

PND 0 to PND 1 99.2 98.1 96.1 91.7 99.4 98.7 (94.6-100.0)

PND 1 to PND 4 97.1 95.9 91.7 76.5 99.3 98.4 (87.0-99.8)

Birth to PND 4 92.8 92.1 84.1 67.9 95.7 95.3 (83.8-98.7)

a

= WIL historical control data

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6.3.2. GENERAL PHYSICAL CONDITION

Summary Data: Table S53

Individual Data: Table A54

The general physical condition (defined as the occurrence and severity of clinical 

findings) of all F1 pups in this study was unaffected by parental administration of the test 

substance. Pups (litters) that were found dead numbered 11(8), 11(6), 16(9), 33(10), and 

7(4) in the control, 50, 100, 175, and 10,000 ppm groups, respectively. One (1), 2(2), 

7(5), and 18(5) pups (litters) in the control, 50, 100, and 175 ppm groups, respectively, 

were missing during PND 1-4 and presumed to have been cannibalized.

6.3.3. OFFSPRING BODY WEIGHTS

Summary Data: Table S54, Table S55

Individual Data: Table A55, Table A56

Historical Control Data: Appendix F

Mean male and female pup body weights and body weight changes during PND 1-4 in 

the 50, 100, 175, and 10,000 ppm groups were unaffected by parental administration of 

the test substance. Higher mean male and female pup birth weights (PND 1) were noted 

for males and females in the 50, 100, and 10,000 ppm groups compared to the control 

group; differences were significant (p<0.01) for male pup body weights only in these 

groups. However, mean body weights on PND 4 and mean body weight gains during 

PND 1-4 in these groups were similar to the control group. Therefore, the higher mean 

male and female pup birth weights on PND 1 were not considered adverse (see 

Section 7.). In the 175 ppm group, mean pup birth weights (PND 1) were similar to the 

control group.

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6.3.4. NECROPSIES OF PUPS FOUND DEAD 

Summary Data: Table S56

Individual Data: Table A57

The numbers of pups (litters) that were found dead numbered 11(8), 11(6), 16(9), 33(10), 

and 7(4) in the control, 50, 100, 175, and 10,000 ppm groups, respectively. One

(no. 91631-08) and 5 (nos. 91654-05, 91654-07, 91654-08, 91654-12, and 

91681-08) pups in the 100 and 175 ppm groups, respectively, were noted with an 

interventricular septal defect (a 1 or 2 mm in diameter opening in the anterior portion of 

the septum); this malformation was considered test substance-related at 175 ppm. At 

100 ppm, only a single pup was affected and postnatal survival was within the WIL

Research historical control data ranges; therefore, the incidence was not considered test 

substance-related.

No other test substance-related malformations or developmental variations were noted at 

any exposure level. In the 175 ppm group, 1 pup (no. 91682-01) was noted with

vertebral agenesis, anal atresia, and fused kidneys; this pup was also noted with a major 

blood vessel variation (retroesophageal right subclavian artery; right subclavian artery

coursed retroesophageal and joined aortic arch adjacent to the ductus arteriosus [no 

brachiocephalic trunk]). Dark red contents in the thoracic cavity were observed for pup 

no. 91622-01 in the 175 ppm group. Because the aforementioned malformations and 

developmental variations were noted in single pups, they were not considered test 

substance-related. A conjoined twin was noted in the control group. 

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7. DISCUSSION

This study was designed to provide information on the potential adverse effects of the test 

substance on male and female reproduction within the scope of a screening study. This 

encompassed gonadal function, mating behavior, conception, parturition, and lactation of 

the F0 generation and the development of offspring from conception through day 4 of 

postnatal life. 

No test substance-related effects on survival were noted in the 10,000 ppm group 

F0 males and females. Test substance-related clinical findings of hypoactivity, decreased 

respiration, completely shut eyelids, and lacrimation were noted for males and females at 

10,000 ppm on the first day of exposure (study day 0); however, these findings were 

resolved by approximately 1 hour following exposure. Salivation and red and/or clear 

material around the mouth and/or nose were noted for F0 males and females in this group 

throughout the respective exposure periods at approximately 15 minutes and/or 1 hour 

following the 5-minute exposure. There were no remarkable macroscopic findings or 

organ weight changes noted for F0 males and females in the 10,000 ppm group at the 

scheduled necropsy. In the 10,000 ppm group F0 males, lower mean body weight gains 

were noted throughout the exposure period and corresponding lower mean food 

consumption was noted during the pre-mating period (study days 0-13). These 

differences resulted in a lower mean body weight in this group compared to the control 

group on study day 28. The aforementioned body weight and food consumption effects 

for F0 males were considered test substance-related and adverse within the context of a 

toxicology study. However, given that the 10,000 ppm exposure level was intended to 

mimic and assess a single maximum exposure in humans, the changes noted in mean 

body weight gain and food consumption that led to a reduction in mean body weight only 

after 28 days of exposure would not be relevant to a single exposure scenario at the same 

exposure level. There were no test substance-related effects on mean water consumption 

for F0 males at 10,000 ppm or on mean body weight, body weight gain, and food and 

water consumption for F0 females at 10,000 ppm. Furthermore, no effects on F0

reproductive performance or F1 offspring were noted in the 10,000 ppm group.

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All F0 males and females in the control, 50, 100, and 175 ppm groups survived to the 

scheduled necropsies. No test substance-related clinical or macroscopic findings were 

noted in the 50, 100, and 175 ppm groups. No adverse test substance-related effects were 

noted on mean body weights, body weight changes, and food consumption for F0 males 

and females at these exposure concentrations during the respective exposure periods. 

Test substance-related, higher mean maternal water consumption was noted in the 

175 ppm group females compared to the control group throughout gestation and was 

considered adverse. Mean water consumption was generally similar to the control group 

for F0 males throughout the exposure period and for F0 females during the pre-mating 

period and lactation.

In the 175 ppm group females, a higher mean pre-coital interval and longer mean 

gestation length were noted compared to the control group; these differences were 

considered test substance-related and adverse. In addition, test substance-related, lower 

postnatal survival was noted in the 175 ppm group compared to the control group during 

PND 0-1, 1-4, and from birth to PND 4 and was considered adverse. 

Higher mean male and female pup birth weights (PND 1) were noted for males and 

females in the 50, 100, and 10,000 ppm groups compared to the control group. This was 

likely due to the slight increases in mean gestation length noted in these groups compared 

to the control group. Fetal weight gain occurs rapidly during late gestation and 

immediately prior to delivery. Although not adverse and within WIL Research historical 

control data, there was a 0.4 to 0.6 day increase in the gestation length noted in these 

groups compared to the control group, which may have attributed to the increased pup 

weights noted. However, mean body weights on PND 4 and mean body weight gains 

during PND 1-4 in these groups were similar to the control group. Therefore, the higher 

mean male and female pup birth weights on PND 1 may have been secondary to the 

slightly increased gestation length and were not considered adverse. In the 175 ppm 

group, mean pup birth weights (PND 1) were similar to the control group. It would be 

expected that the longer gestation length would produce higher mean birth weights in 

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pups, as mentioned previously. An increased gestation length that was outside of the

WIL Research historical control values and considered adverse was noted at 175 ppm. 

The lack of a statistical increase in the mean pup body weights at 175 ppm was likely due 

to a potential developmental delay or a reduction in mean pup body weights that was 

masked by the increased gestation period. 

At the necropsy for F1 pups that were found dead, an increased incidence of 

interventricular septal defect was noted in the 175 ppm group. Experimentally induced 

interventricular defects have been shown to close during postnatal development and can 

be considered a developmental delay in the cardiac system that may or may not be 

considered adverse depending on the size of the opening and the impact on viability and 

growth of the pups (Fleeman, et al., 2004). The interventricular defects in this study

were noted in pups that were found dead. Therefore, while these observations may have 

been related to the apparent developmental delay noted in the 175 ppm group, they were 

considered test substance-related and adverse when coupled with the reduction in 

postnatal survival noted in this group. 

F0 male and female reproductive indices, spermatogenic endpoints, and the mean 

numbers of corpora lutea, implantation sites, and unaccounted-for sites were similar to 

the control group values at 50, 100, and 175 ppm. The number of days between pairing 

and coitus and mean gestation lengths were unaffected by test substance exposure at 

50 and 100 ppm. No noteworthy findings were observed during the process of parturition 

and no remarkable organ weight changes were noted for parental animals at exposure 

levels of 50, 100, and 175 ppm. In F1 pups, mean numbers of pups born, live litter size, 

and percentage of males per litter at birth in the 50, 100, and 175 ppm groups were 

similar to the control group values. In the 50 and 100 ppm groups, postnatal survival was 

unaffected by test substance exposure. No noteworthy findings were noted on the general 

physical condition of F1 pups at 50, 100, and 175 ppm and at necropsy for F1 pups found 

dead at 50 and 100 ppm. 

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8. CONCLUSIONS

In the 10,000 ppm group, adverse clinical signs (hypoactivity, decreased respiration, 

completely shut eyelids, and lacrimation) were noted for all F0 males and females on the 

first day of test substance exposure. These findings were noted at approximately

15 minutes following test substance exposure and were resolved by approximately 1 hour 

following exposure. In addition, lower mean F0 male body weights, body weight gains, 

and food consumption were noted at this exposure level; no test substance-related effects 

on body weight or food consumption parameters were noted for F0 females. The 

aforementioned body weight and food consumption effects for F0 males were considered 

test substance-related and adverse within the context of a toxicology study. However, 

given that the 10,000 ppm exposure level was intended to mimic and assess a single 

maximum exposure in humans, the changes noted in mean body weight gain and food 

consumption that led to a reduction in mean body weight only after 28 days of exposure 

would not be relevant to a single exposure scenario at the same exposure level. No 

effects on F0 reproductive performance and F1 offspring were noted at 10,000 ppm when 

2-Bromo-3,3,3-Trifluoropropene was administered as a daily 5-minute whole-body

inhalation exposure.

Under the conditions of this screening study, an exposure level of 100 ppm was 

considered to be the no-observed-adverse-effect level (NOAEL) for female systemic 

toxicity, reproductive toxicity, and neonatal toxicity based on the increase in mean water 

consumption for females during gestation, longer mean pre-coital interval, longer mean 

gestation length, and the reduced postnatal survival noted in the 175 ppm group. The 

NOAEL for F0 male systemic toxicity was considered to be 175 ppm, the highest 

exposure concentration tested, based on the lack of adverse effects on systemic toxicity

for males at any 6-hour exposure regimen or at the 10,000 ppm 5-minute exposure. 

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WIL-6550 1 

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9. REPORT REVIEW AND APPROVAL 

Report Authored and Approved By: 

---I&* A CCLLd,.. cL> 

Tadye L. Edwards, BS 

Senior Toxicologist, Developmental 

and Reproductive Toxicology 

Study Director 

Report Prepared By: A 

Study Aglyst 

Report Reviewed By: 

n 

, -y 

Jaime L. Mesnard, MS 

Group Supervisor, 

Reporting & Technical Support Services 

Eddie D. Slo’Eer, PhD 

Associate Director, Developmental and 

Reproductive Toxicology 

Date 

=ua/y Date 

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10. QUALITY ASSURANCE STATEMENT

Date(s) of

Inspection(s) Phase Inspected

Date(s) Findings

Reported to Study 

Director and

Management

25-Sep-2013 Protocol 25-Sep-2013

14-Oct-2013,

15-Oct-2013 Test Article Exposure 15-Oct-2013

22-Oct-2013 Protocol Amendment 1 22-Oct-2013

20-Nov-2013 Parturition 20-Nov-2013

25-Nov-2013 Necropsy 25-Nov-2013

18-Dec-2013 Trimming of Tissues 18-Dec-2013

03-Jan-2014 Protocol Amendment 2 03-Jan-2014

29-Jan-2014,

11-Feb-2014 Study Records (I-1) 11-Feb-2014

31-Jan-2014 Study Records (Ex-2) 31-Jan-2014

31-Jan-2014,

07-Feb-2014 Study Records (Ex-1) 07-Feb-2014

06-Feb-2014,

07-Feb-2014 Study Records (Ex-3) 07-Feb-2014

07-Feb-2014 Exposure Atmosphere Generation Report 07-Feb-2014

07-Feb-2014 Study Records (Ex-4) 07-Feb-2014

07-Feb-2014 Study Records (Ex-5) 07-Feb-2014

07-Feb-2014 Study Records (Ex-6) 07-Feb-2014

07-Feb-2014 Study Records (Ex-1) Supplemental 07-Feb-2014

10-Feb-2014 Study Records (N-1) 10-Feb-2014

10-Feb-2014 Study Records (N-2) 10-Feb-2014

10-Feb-2014 Study Records (H-1) 10-Feb-2014

10-Feb-2014 Study Records (Pathology Data) 10-Feb-2014

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WIL-65501 

American Pacific Corporation 

2-Bromo-3,3,3 -Trifluoropropene 

Date(s) of 

Inspection(s) Phase Inspected 

1 1 -Feb-20 14 Pathology Report 

Date(s) Findings 

Reported to Study 

Director and 

Manapement 

1 1 -Feb-20 14 

1 1 -Feb-2014 Study Records (1-2) 1 1 -Feb-20 14 

1 1 -Feb-2014 Study Records (1-3) 1 1 -Feb-20 14 

1 1 -Feb-2014 Study Records (1-4) 1 1 -Feb-20 14 

1 1 -Feb-20 14 Study Records (1-5) 1 1 -Feb-20 14 

1 1 -Feb-2014 Study Records (1-6) 1 1 -Feb-20 14 

13-Feb-2014 Report (without Inhalation or Pathology Appendices) 13-Feb-20 14 

13-Mar-20 14 Final Inhalation Report 13-Mar-201 4 

17-Mar-20 14 Final Pathology Report 17-Mar-201 4 

1 8-Mar-20 14 Study Records (N-2) Supplemental 18-Mar-20 14 

19-Mar-20 14 Amendment to the Final Inhalation Report 1 9-Mar-20 1 4 

19-Mar-20 14 Final Report 19-Mar-201 4 

This study was inspected in accordance with the applicable GLP Regulations, WIL 

Research’s SOPs, and the protocol and protocol amendments, with the following 

exception: The data located in Appendix B (Certificate of Analysis) were the 

responsibility of the Sponsor. A yearly internal facility inspection is conducted by the 

WIL Research Quality Assurance Department. 

This report accurately reflects the data generated during the study. The methods and 

procedures used in the study were those specified in the protocol, its amendments, and 

WIL Research’s SOPs. 

Alan D. Deppe, BA ’ 

Quality Assurance Representative 

I 

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WIL Research Hillsborough 

3 10 Millstone Drive 

Hillsborough, NC 27278 

WIL-65501 

American Pacific Corporation 

Date(s) Findings Date(s) Reported 

Reported To Date (s) Findings To Study 

Date(s) of Principal Reported To Test Director and 

Inspection Phase Inspected Investigator Site Management Testing Facility 

27-Dec-20 13 Automated IHC Staining 27-Dec-2013 27-Dec-2013 02-Jan-20 14 

and Coverslipping 

I O& 12-Mar- Histology Documentation 12-Mar-20 14 12-Mar-20 14 1 8-Mar-20 14 

2014 

The portions of this study conducted at WIL Research Hillsborough were inspected in 

accordance with the applicable Good Laboratory Practice Regulations, SOPs and 

protocol and protocol amendments. A yearly internal facility inspection is conducted by 

the Quality Assurance Department. 

The methods and procedures used in the portions of this study conducted at WIL 

Research Hillsborough were those specified in the protocol, its amendments, and SOPs. 

/B JYdv 2014 

Date 

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11. REFERENCES

Blazak, W.F.; Ernst, T.L.; Stewart, B.E. Potential indicators of reproductive toxicity: 

testicular sperm production and epididymal sperm number, transit time and motility

in Fischer 344 rats. Fundamental and Applied Toxicology 1985, 5, 1097-1103.

Bolon, B.; Bucci, T.J.; Warbritton, A.R.; Chen, J.J.; Mattison, D.R.; Heindel, J.J. 

Differential follicle counts as a screen for chemically induced ovarian toxicity in 

mice: results from continuous breeding bioassays. Fundamental and Applied 

Toxicology 1997, 39(1), 1-10.

Brooker, A.J. 2-bromo-3,3,3-trifluoropropene: Reproductive/Developmental 

Toxicity Screening Study in the CD Rat by Inhalation Administration (Study No. 

WAG0015). Huntingdon Life Sciences. 2013.

Bucci, T.J.; Bolon, B.; Warbritton, A.R.; Chen, J.J.; Heindel, J.J. Influence of 

sampling on the reproducibility of ovarian follicle counts in mouse toxicity studies. 

Reproductive Toxicology 1997, 11(5), 689-696.

Dawson, A.B. A note on the staining of the skeleton of cleared specimens with 

Alizarin Red S. Stain Technology 1926, 1, 123-124.

Dunn, O.J. Multiple comparisons using rank sums. Technometrics 1964, 6(3), 

241-252.

Dunnett, C.W. New tables for multiple comparisons with a control. Biometrics

1964, 20, 482-491.

Fleeman, T.L.; Cappon, G.D.; and Hurtt, M.E. Postnatal Closure of Membranous 

Ventricular Septal Defects in Sprague-Dawley Rat Pups After Maternal Exposure 

With Trimethadione Birth Defects Research (Part B) 2004, 71:185-190.

Hollander, M.; Wolfe, D.A. Nonparametric Statistical Methods, 2nd ed.; Hollander, 

M., Wolfe, D.A., Eds.; John Wiley and Sons, Inc.: New York, NY, 1999; p 468. 

Horrell, P.J. Agent 873: An Inhalation Study to Investigate the Cardiac Sensitisation 

Potential in the Beagle (Study No. AAS 001/014630). Huntingdon Life Sciences, 

Ltd. 2002.

Kruskal, W.H.; Wallis, W.A. Use of ranks in one-criterion variance analysis. 

Journal of the American Statistical Association 1952, 47, 583-621.

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Linder, R.E.; Strader, L.F.; Slott, V.L.; Suarez, J.D. Endpoints of spermatotoxicity in 

the rat after short duration exposures to fourteen reproductive toxicants. 

Reproductive Toxicology 1992, 6, 491-505.

National Research Council. Guide for the Care and Use of Laboratory Animals, 

Institute of Laboratory Animal Resources, Commission on Life Sciences; National 

Academy Press: Washington, DC, 1996.

Picut, C.A.; Swanson, C.L.; Scully, K.L.; Roseman, V.C.; Parker, R.F.; Remick, 

A.K. Ovarian Follicle Counts Using Proliferating Cell Nuclear Antigen (PCNA) and 

Semi-Automated Image Analysis in Rats. Toxicologic Pathology 2008, May 8.

Salewski, E. Färbemethode zum makroskopischen Nachweis von 

Implantationsstellen am Uterus der Ratte. [Staining method for a macroscopic test 

for implantation sites in the uterus of the rat]. Naunyn - Schmiedebergs Archiv für 

Experimentelle Pathologie und Pharmakologie 1964, 247, 367.

Snedecor, G.W.; Cochran, W.G. One-Way Classifications; Analysis of Variance. 

In Statistical Methods, 7th ed.; The Iowa State University Press: Ames, IA, 1980; 

pp 215-237.

Steel, R.G.D.; Torrie, J.H. Principles and Procedures of Statistics, A Biometrical 

Approach, 2nd ed.; McGraw-Hill Book Company: New York, NY, 1980; 

pp 504-506.

Stuckhardt, J.L.; Poppe, S.M. Fresh visceral examination of rat and rabbit fetuses 

used in teratogenicity testing. Teratogenesis, Carcinogenesis and Mutagenesis

1984, 4, 181-188.

 Page 68 of 1107
WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

12. DATA RETENTION

The Sponsor has title to all documentation records, raw data, specimens, or other work 

product generated during the performance of the study. All remaining work product 

generated by WIL Research, including raw paper data and specimens, are retained in the 

WIL Research Archives as specified in the study protocol. All work product generated at 

WIL Research Hillsborough will be returned to WIL Research Ashland. 

Reserve samples of the test substance, pertinent electronic storage media, and the original 

final report are retained in the WIL Research Archives in compliance with regulatory

requirements.

 Page 69 of 1107
WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

13. ABBREVIATIONS

The following abbreviations may apply to this report:

μ - micro

AAALAC - Association for Assessment and Accreditation of Laboratory

Animal Care

ANOVA - analysis of variance

BSA - Bovine serum albumin

CEO - correlates with externally observed

cm - centimeter

dL - deciliter

DNA - deoxyribonucleic acid

EPA - Environmental Protection Agency

exp. - expiration

g - gram

GC - gas chromatograph

GLP - Good Laboratory Practices

hr - hour(s)

kg - kilogram

L - liter

M - molar

mg - milligram

mL - milliliter

mm - millimeter

ms - milliseconds

mM - millimolar

NA - not applicable

no(s). - number(s)

OECD - Organisation for Economic Cooperation and Development

PAS - Periodic Acid Schiff

PND - Postnatal day

ppm - parts per million

SOP - standard operating procedure

TSCA - Toxic Substances Control Act

WTDMSTM - WIL Toxicology Data Management System

wt(s). - weight(s)

 Page 70 of 1107
WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

SUMMARY TABLES

 Page 71 of 1107
 TABLE S1 (F0 MALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS

 ----- M A L E -----

-----------------------------------------------------------------------------------------------------------------------------------

 TABLE RANGE: 10-14-13 TO 11-12-13

 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NORMAL

-NO SIGNIFICANT CLINICAL OBSERVATIONS 51/11 45/11 42/10 40/10 54/11

DISPOSITION

-SCHEDULED EUTHANASIA 12/12 12/12 12/12 12/12 12/12

BODY/INTEGUMENT

-HAIR LOSS RIGHT FORELIMB 9/ 2 11/ 4 16/ 4 18/ 5 6/ 2

-HAIR LOSS LEFT FORELIMB 9/ 2 11/ 4 16/ 4 20/ 6 5/ 1

-HAIR LOSS LEFT INGUINAL AREA 0/ 0 3/ 1 0/ 0 0/ 0 0/ 0

EYES/EARS/NOSE

-DRIED RED MATERIAL AROUND LEFT EYE 0/ 0 0/ 0 3/ 1 0/ 0 0/ 0

-DRIED RED MATERIAL AROUND RIGHT EYE 0/ 0 0/ 0 2/ 1 0/ 0 0/ 0

ORAL/DENTAL

-UPPER INCISORS MALALIGNED 0/ 0 0/ 0 3/ 1 0/ 0 0/ 0

-TEETH LONG; TRIMMED 0/ 0 0/ 0 2/ 1 0/ 0 0/ 0

-----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

 PCSUv4.07

 11/25/2013

Page 72 of 1107
 TABLE S2 (F0 MALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS

 ----- M A L E -----

-----------------------------------------------------------------------------------------------------------------------------------

 TABLE RANGE: 10-14-13 TO 11-11-13

 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NORMAL

-NO SIGNIFICANT CLINICAL OBSERVATIONS 0/ 0 0/ 0 0/ 0 0/ 0 53/11

BEHAVIOR/CNS

-HYPOACTIVITY 0/ 0 0/ 0 0/ 0 0/ 0 12/12

BODY/INTEGUMENT

-WET CLEAR MATERIAL RIGHT FORELIMB 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1

-WET CLEAR MATERIAL LEFT FORELIMB 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1

CARDIO-PULMONARY

-DECREASED RESPIRATION 0/ 0 0/ 0 0/ 0 0/ 0 12/12

EYES/EARS/NOSE

-DRIED RED MATERIAL AROUND NOSE 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1

-WET RED MATERIAL AROUND NOSE 0/ 0 0/ 0 0/ 0 0/ 0 12/ 6

-EYELIDS COMPLETELY SHUT 0/ 0 0/ 0 0/ 0 0/ 0 12/12

-LACRIMATION 0/ 0 0/ 0 0/ 0 0/ 0 12/12

-DRIED RED MATERIAL AROUND LEFT EYE 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1

ORAL/DENTAL

-WET CLEAR MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 0/ 0 162/12

-----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

Page 73 of 1107
 TABLE S2 (F0 MALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS

 ----- M A L E -----

-----------------------------------------------------------------------------------------------------------------------------------

 TABLE RANGE: 10-14-13 TO 11-11-13

 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

ORAL/DENTAL

-SALIVATION 0/ 0 0/ 0 0/ 0 0/ 0 254/12

-WET RED MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 0/ 0 11/ 3

-----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

 PCSUv4.07

 11/25/2013

 R:01/20/2014

Page 74 of 1107
 TABLE S3 (F0 MALES - 1 HOUR POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS

 ----- M A L E -----

-----------------------------------------------------------------------------------------------------------------------------------

 TABLE RANGE: 10-14-13 TO 11-11-13

 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NORMAL

-NO SIGNIFICANT CLINICAL OBSERVATIONS 0/ 0 0/ 0 0/ 0 0/ 0 261/12

EYES/EARS/NOSE

-DRIED RED MATERIAL AROUND NOSE 0/ 0 0/ 0 0/ 0 0/ 0 14/ 5

-WET RED MATERIAL AROUND NOSE 0/ 0 0/ 0 0/ 0 0/ 0 10/ 6

-DRIED RED MATERIAL AROUND LEFT EYE 0/ 0 0/ 0 0/ 0 0/ 0 2/ 1

ORAL/DENTAL

-WET CLEAR MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 0/ 0 40/11

-SALIVATION 0/ 0 0/ 0 0/ 0 0/ 0 2/ 2

-WET RED MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 0/ 0 24/ 6

-DRIED RED MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 0/ 0 8/ 4

-----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

 PCSUv4.07

 11/25/2013

 R:01/20/2014

Page 75 of 1107
 TABLE S4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS

 ----- M A L E -----

-----------------------------------------------------------------------------------------------------------------------------------

 TABLE RANGE: 10-14-13 TO 11-11-13

 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NORMAL

-NO SIGNIFICANT CLINICAL OBSERVATIONS 327/12 314/12 324/12 318/12 333/12

EYES/EARS/NOSE

-DRIED RED MATERIAL AROUND NOSE 15/ 4 28/11 15/ 7 21/10 7/ 4

-WET RED MATERIAL AROUND NOSE 0/ 0 0/ 0 1/ 1 0/ 0 0/ 0

-DRIED RED MATERIAL AROUND LEFT EYE 0/ 0 0/ 0 3/ 1 0/ 0 2/ 1

-DRIED RED MATERIAL AROUND RIGHT EYE 0/ 0 0/ 0 3/ 1 0/ 0 1/ 1

ORAL/DENTAL

-WET CLEAR MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 2/ 2 0/ 0

-WET RED MATERIAL AROUND MOUTH 0/ 0 1/ 1 0/ 0 1/ 1 0/ 0

-DRIED RED MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0

-----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

 PCSUv4.07

 11/25/2013

 R:01/20/2014

Page 76 of 1107
 TABLE S5 (F0 FEMALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS

 ----- F E M A L E -----

-----------------------------------------------------------------------------------------------------------------------------------

 TABLE RANGE: 10-14-13 TO 12-05-13

 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NORMAL

-NO SIGNIFICANT CLINICAL OBSERVATIONS 71/12 84/12 79/12 87/12 58/11

DISPOSITION

-SCHEDULED EUTHANASIA; LACTATION DAY 4 12/12 12/12 12/12 10/10 12/12

-SCHEDULED EUTHANASIA; TOTAL LITTER LOSS 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0

-SCHEDULED EUTHANASIA; POST-COHABITATION 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0

 DAY 25

BODY/INTEGUMENT

-HAIR LOSS RIGHT FORELIMB 11/ 3 3/ 2 7/ 4 9/ 2 22/ 4

-HAIR LOSS LEFT FORELIMB 9/ 2 3/ 2 8/ 4 9/ 2 23/ 5

-HAIR LOSS VENTRAL ABDOMINAL AREA 6/ 2 0/ 0 0/ 0 0/ 0 5/ 1

-HAIR LOSS RIGHT INGUINAL AREA 1/ 1 0/ 0 0/ 0 0/ 0 4/ 1

-HAIR LOSS LEFT INGUINAL AREA 0/ 0 0/ 0 0/ 0 0/ 0 4/ 1

-HAIR LOSS LEFT HINDLIMB 0/ 0 0/ 0 0/ 0 0/ 0 5/ 1

-HAIR LOSS RIGHT HINDLIMB 0/ 0 0/ 0 0/ 0 0/ 0 3/ 2

EYES/EARS/NOSE

-DRIED RED MATERIAL AROUND NOSE 0/ 0 1/ 1 1/ 1 1/ 1 0/ 0

SPECIAL II

-BREEDING PERIOD COMPLETE; FEMALE 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0

 SEPARATED FROM MALE AND PLACED INTO CLEAN CAGING

-----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

 PCSUv4.07

 01/29/2014

Page 77 of 1107
 TABLE S6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS

 ----- F E M A L E -----

-----------------------------------------------------------------------------------------------------------------------------------

 TABLE RANGE: 10-14-13 TO 11-20-13

 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NORMAL

-NO SIGNIFICANT CLINICAL OBSERVATIONS 0/ 0 0/ 0 0/ 0 0/ 0 176/12

BEHAVIOR/CNS

-HYPOACTIVITY 0/ 0 0/ 0 0/ 0 0/ 0 12/12

BODY/INTEGUMENT

-WET CLEAR MATERIAL RIGHT FORELIMB 0/ 0 0/ 0 0/ 0 0/ 0 13/ 2

-WET CLEAR MATERIAL LEFT FORELIMB 0/ 0 0/ 0 0/ 0 0/ 0 12/ 2

-WET CLEAR MATERIAL VENTRAL NECK 0/ 0 0/ 0 0/ 0 0/ 0 14/ 2

CARDIO-PULMONARY

-DECREASED RESPIRATION 0/ 0 0/ 0 0/ 0 0/ 0 12/12

EYES/EARS/NOSE

-DRIED RED MATERIAL AROUND NOSE 0/ 0 0/ 0 0/ 0 0/ 0 11/ 7

-WET RED MATERIAL AROUND NOSE 0/ 0 0/ 0 0/ 0 0/ 0 26/10

-EYELIDS COMPLETELY SHUT 0/ 0 0/ 0 0/ 0 0/ 0 12/12

-LACRIMATION RIGHT EYE 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1

-LACRIMATION 0/ 0 0/ 0 0/ 0 0/ 0 12/12

ORAL/DENTAL

-WET CLEAR MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 0/ 0 180/12

-----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

Page 78 of 1107
 TABLE S6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS

 ----- F E M A L E -----

-----------------------------------------------------------------------------------------------------------------------------------

 TABLE RANGE: 10-14-13 TO 11-20-13

 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

ORAL/DENTAL

-SALIVATION 0/ 0 0/ 0 0/ 0 0/ 0 127/12

-WET RED MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 0/ 0 19/ 7

-DRIED RED MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 0/ 0 6/ 3

-----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

 PCSUv4.07

 01/24/2014

 R:01/24/2014

Page 79 of 1107
 TABLE S7 (F0 FEMALES - 1 HOUR POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS

 ----- F E M A L E -----

-----------------------------------------------------------------------------------------------------------------------------------

 TABLE RANGE: 10-14-13 TO 11-20-13

 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NORMAL

-NO SIGNIFICANT CLINICAL OBSERVATIONS 0/ 0 0/ 0 0/ 0 0/ 0 392/12

BODY/INTEGUMENT

-WET CLEAR MATERIAL RIGHT FORELIMB 0/ 0 0/ 0 0/ 0 0/ 0 16/ 1

-WET CLEAR MATERIAL LEFT FORELIMB 0/ 0 0/ 0 0/ 0 0/ 0 17/ 1

-WET CLEAR MATERIAL VENTRAL NECK 0/ 0 0/ 0 0/ 0 0/ 0 18/ 1

-WET CLEAR MATERIAL VENTRAL ABDOMINAL 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1

 AREA

EYES/EARS/NOSE

-DRIED RED MATERIAL AROUND NOSE 0/ 0 0/ 0 0/ 0 0/ 0 13/ 7

-WET RED MATERIAL AROUND NOSE 0/ 0 0/ 0 0/ 0 0/ 0 2/ 1

ORAL/DENTAL

-WET CLEAR MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 0/ 0 17/ 2

-WET RED MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 0/ 0 2/ 1

-DRIED RED MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 0/ 0 6/ 5

-----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

 PCSUv4.07

 01/20/2014

 R:01/20/2014

Page 80 of 1107
 TABLE S8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS

 ----- F E M A L E -----

-----------------------------------------------------------------------------------------------------------------------------------

 TABLE RANGE: 10-14-13 TO 12-04-13

 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NORMAL

-NO SIGNIFICANT CLINICAL OBSERVATIONS 440/12 415/12 414/12 429/12 421/12

EYES/EARS/NOSE

-DRIED RED MATERIAL AROUND NOSE 3/ 3 28/ 9 23/11 47/12 10/ 6

-WET RED MATERIAL AROUND NOSE 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0

ORAL/DENTAL

-DRIED RED MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 0/ 0 2/ 2

-----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

 PCSUv4.07

 01/20/2014

 R:01/20/2014

Page 81 of 1107
 TABLE S9 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF BODY WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 0

 MEAN 371. 372. 374. 370. 370.

 % DIFFERENCE 0.3 0.8 -0.3 -0.3

 S.D. 16.0 19.9 17.7 16.5 18.6

 S.E. 4.6 5.8 5.1 4.8 5.4

 N 12 12 12 12 12

 DAY 7

 MEAN 387. 393. 386. 384. 375.

 % DIFFERENCE 1.6 -0.3 -0.8 -3.1

 S.D. 17.3 22.2 13.7 20.0 19.1

 S.E. 5.0 6.4 4.0 5.8 5.5

 N 12 12 12 12 12

 DAY 13

 MEAN 407. 417. 401. 406. 387.

 % DIFFERENCE 2.5 -1.5 -0.2 -4.9

 S.D. 21.2 23.2 16.0 19.8 23.3

 S.E. 6.1 6.7 4.6 5.7 6.7

 N 12 12 12 12 12

 DAY 21

 MEAN 424. 436. 415. 423. 404.

 % DIFFERENCE 2.8 -2.1 -0.2 -4.7

 S.D. 25.1 28.2 16.0 17.1 23.6

 S.E. 7.3 8.1 4.6 4.9 6.8

 N 12 12 12 12 12

 DAY 28

 MEAN 448. 456. 431. 438. 418.*

 % DIFFERENCE 1.8 -3.8 -2.2 -6.7

 S.D. 26.8 32.1 18.1 21.9 24.9

 S.E. 7.7 9.3 5.2 6.3 7.2

 N 12 12 12 12 12

-----------------------------------------------------------------------------------------------------------------------------------

* = Significantly different from the control group at 0.05 using Dunnett's test

 PJTBWSUv5.20

 11/25/2013

Page 82 of 1107
 TABLE S10 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF BODY WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 0- 7

 MEAN 16. 20. 12. 14. 5.*

 S.D. 6.8 9.7 10.8 13.2 8.0

 S.E. 2.0 2.8 3.1 3.8 2.3

 N 12 12 12 12 12

 DAY 7- 13

 MEAN 20. 24. 16. 22. 12.*

 S.D. 6.7 5.3 9.2 6.3 7.5

 S.E. 1.9 1.5 2.7 1.8 2.2

 N 12 12 12 12 12

 DAY 13- 21

 MEAN 18. 20. 14. 17. 17.

 S.D. 8.9 6.2 6.9 10.1 6.4

 S.E. 2.6 1.8 2.0 2.9 1.8

 N 12 12 12 12 12

 DAY 21- 28

 MEAN 24. 20. 16.* 15.* 13.**

 S.D. 6.4 5.5 7.6 9.9 6.6

 S.E. 1.8 1.6 2.2 2.9 1.9

 N 12 12 12 12 12

 DAY 0- 13 (PRE-MATING PERIOD)

 MEAN 36. 44. 27. 36. 17.**

 S.D. 10.1 12.8 16.9 15.1 10.1

 S.E. 2.9 3.7 4.9 4.3 2.9

 N 12 12 12 12 12

-----------------------------------------------------------------------------------------------------------------------------------

* = Significantly different from the control group at 0.05 using Dunnett's test

** = Significantly different from the control group at 0.01 using Dunnett's test

MEAN DIFFERENCES CALCULATED FROM INDIVIDUAL DIFFERENCES

Page 83 of 1107
 TABLE S10 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF BODY WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 0- 28 (ENTIRE TREATMENT PERIOD)

 MEAN 78. 84. 57.* 68. 48.**

 S.D. 17.5 19.1 15.1 19.7 12.4

 S.E. 5.0 5.5 4.3 5.7 3.6

 N 12 12 12 12 12

-----------------------------------------------------------------------------------------------------------------------------------

* = Significantly different from the control group at 0.05 using Dunnett's test

** = Significantly different from the control group at 0.01 using Dunnett's test

MEAN DIFFERENCES CALCULATED FROM INDIVIDUAL DIFFERENCES

 PJTBWSUv5.20

 11/25/2013

 R:01/07/2014

Page 84 of 1107
 TABLE S11 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF BODY WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 0

 MEAN 252. 246. 243. 252. 246.

 % DIFFERENCE -2.4 -3.6 0.0 -2.4

 S.D. 11.7 12.8 15.1 15.8 12.8

 S.E. 3.4 3.7 4.4 4.6 3.7

 N 12 12 12 12 12

 DAY 7

 MEAN 265. 262. 261. 264. 257.

 % DIFFERENCE -1.1 -1.5 -0.4 -3.0

 S.D. 14.7 14.3 16.6 17.6 10.6

 S.E. 4.2 4.1 4.8 5.1 3.1

 N 12 12 12 12 12

 DAY 13

 MEAN 276. 275. 278. 282. 269.

 % DIFFERENCE -0.4 0.7 2.2 -2.5

 S.D. 16.1 17.6 18.1 19.0 9.1

 S.E. 4.7 5.1 5.2 5.5 2.6

 N 12 12 12 12 12

-----------------------------------------------------------------------------------------------------------------------------------

None significantly different from control group

 PJTBWSUv5.20

 01/07/2014

Page 85 of 1107
 TABLE S12 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF BODY WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 0- 7

 MEAN 14. 16. 18. 12. 12.

 S.D. 11.4 5.1 8.2 9.6 7.8

 S.E. 3.3 1.5 2.4 2.8 2.3

 N 12 12 12 12 12

 DAY 7- 13

 MEAN 10. 13. 16. 18. 11.

 S.D. 8.3 13.1 7.8 4.4 4.9

 S.E. 2.4 3.8 2.2 1.3 1.4

 N 12 12 12 12 12

 DAY 0- 13 (PRE-MATING PERIOD)

 MEAN 24. 29. 35. 31. 23.

 S.D. 11.7 12.5 9.4 11.1 9.5

 S.E. 3.4 3.6 2.7 3.2 2.7

 N 12 12 12 12 12

-----------------------------------------------------------------------------------------------------------------------------------

None significantly different from control group

MEAN DIFFERENCES CALCULATED FROM INDIVIDUAL DIFFERENCES

 PJTBWSUv5.20

 01/07/2014

 R:01/07/2014

Page 86 of 1107
 TABLE S13 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF BODY WEIGHTS DURING GESTATION [G]

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 0

 MEAN 277. 276. 279. 289. 269.

 % DIFFERENCE -0.4 0.7 4.3 -2.9

 S.D. 18.1 15.7 21.5 27.1 8.5

 S.E. 5.2 4.5 6.2 8.2 2.5

 N 12 12 12 11 12

 DAY 4

 MEAN 302. 301. 302. 306. 292.

 % DIFFERENCE -0.3 0.0 1.3 -3.3

 S.D. 16.4 12.9 21.5 23.7 9.9

 S.E. 4.7 3.7 6.2 7.1 2.8

 N 12 12 12 11 12

 DAY 7

 MEAN 314. 314. 314. 318. 303.

 % DIFFERENCE 0.0 0.0 1.3 -3.5

 S.D. 18.3 14.9 22.6 27.7 11.8

 S.E. 5.3 4.3 6.5 8.3 3.4

 N 12 12 12 11 12

 DAY 11

 MEAN 336. 332. 332. 338. 323.

 % DIFFERENCE -1.2 -1.2 0.6 -3.9

 S.D. 20.9 15.4 22.2 28.2 14.7

 S.E. 6.0 4.4 6.4 8.5 4.2

 N 12 12 12 11 12

 DAY 14

 MEAN 354. 346. 348. 349. 336.

 % DIFFERENCE -2.3 -1.7 -1.4 -5.1

 S.D. 20.3 15.2 23.3 28.1 15.8

 S.E. 5.9 4.4 6.7 8.5 4.6

 N 12 12 12 11 12

-----------------------------------------------------------------------------------------------------------------------------------

None significantly different from control group

NONGRAVID WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 87 of 1107
 TABLE S13 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF BODY WEIGHTS DURING GESTATION [G]

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 17

 MEAN 385. 378. 378. 380. 369.

 % DIFFERENCE -1.8 -1.8 -1.3 -4.2

 S.D. 22.2 19.7 22.8 29.7 17.7

 S.E. 6.4 5.7 6.6 9.0 5.1

 N 12 12 12 11 12

 DAY 20

 MEAN 427. 425. 427. 430. 415.

 % DIFFERENCE -0.5 0.0 0.7 -2.8

 S.D. 25.6 23.1 28.0 31.4 17.9

 S.E. 7.4 6.7 8.1 9.5 5.2

 N 12 12 12 11 12

-----------------------------------------------------------------------------------------------------------------------------------

None significantly different from control group

NONGRAVID WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

 PGBWSUv5.10

 01/07/2014

Page 88 of 1107
 TABLE S14 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF BODY WEIGHT CHANGES DURING GESTATION [G]

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 0- 4

 MEAN 25. 24. 22. 17.* 24.

 S.D. 7.4 5.8 8.4 5.1 7.4

 S.E. 2.1 1.7 2.4 1.6 2.1

 N 12 12 12 11 12

 DAY 4- 7

 MEAN 12. 13. 12. 12. 10.

 S.D. 4.9 3.8 5.6 5.8 4.1

 S.E. 1.4 1.1 1.6 1.7 1.2

 N 12 12 12 11 12

 DAY 7- 11

 MEAN 21. 18. 18. 19. 20.

 S.D. 5.4 4.4 7.3 4.2 5.2

 S.E. 1.6 1.3 2.1 1.3 1.5

 N 12 12 12 11 12

 DAY 11- 14

 MEAN 18. 14. 16. 12.** 14.*

 S.D. 4.4 4.8 3.5 3.3 3.3

 S.E. 1.3 1.4 1.0 1.0 0.9

 N 12 12 12 11 12

 DAY 14- 17

 MEAN 32. 31. 31. 31. 33.

 S.D. 4.8 8.3 6.4 5.4 6.7

 S.E. 1.4 2.4 1.9 1.6 1.9

 N 12 12 12 11 12

-----------------------------------------------------------------------------------------------------------------------------------

* = Significantly different from the control group at 0.05 using Dunnett's test

** = Significantly different from the control group at 0.01 using Dunnett's test

MEAN DIFFERENCES CALCULATED FROM INDIVIDUAL DIFFERENCES

NONGRAVID WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 89 of 1107
 TABLE S14 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF BODY WEIGHT CHANGES DURING GESTATION [G]

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 17- 20

 MEAN 42. 48. 49. 51. 46.

 S.D. 5.3 6.5 12.2 6.8 5.0

 S.E. 1.5 1.9 3.5 2.1 1.4

 N 12 12 12 11 12

 DAY 0- 20

 MEAN 150. 149. 147. 141. 146.

 S.D. 17.9 12.9 22.1 10.2 16.6

 S.E. 5.2 3.7 6.4 3.1 4.8

 N 12 12 12 11 12

-----------------------------------------------------------------------------------------------------------------------------------

None significantly different from control group

MEAN DIFFERENCES CALCULATED FROM INDIVIDUAL DIFFERENCES

NONGRAVID WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

 PGBWSUv5.10

 01/07/2014

Page 90 of 1107
 TABLE S15 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF BODY WEIGHTS DURING LACTATION [G]

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1

 MEAN 326. 316. 317. 326. 307.

 % DIFFERENCE -3.1 -2.8 0.0 -5.8

 S.D. 28.2 23.7 26.0 29.1 18.7

 S.E. 8.1 6.8 7.5 8.8 5.4

 N 12 12 12 11 12

 DAY 4

 MEAN 342. 327. 326. 337. 326.

 % DIFFERENCE -4.4 -4.7 -1.5 -4.7

 S.D. 22.6 23.5 28.3 33.2 17.9

 S.E. 6.5 6.8 8.2 10.5 5.2

 N 12 12 12 10 12

-----------------------------------------------------------------------------------------------------------------------------------

None significantly different from control group

 PLBWSUv5.08

 01/07/2014

Page 91 of 1107
 TABLE S16 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF BODY WEIGHT CHANGES DURING LACTATION [G]

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1- 4

 MEAN 16. 11. 8. 10. 20.

 S.D. 13.0 12.0 7.2 10.6 12.9

 S.E. 3.8 3.5 2.1 3.4 3.7

 N 12 12 12 10 12

-----------------------------------------------------------------------------------------------------------------------------------

None significantly different from control group

MEAN DIFFERENCES CALCULATED FROM INDIVIDUAL DIFFERENCES

 PLBWSUv5.08

 01/07/2014

Page 92 of 1107
 TABLE S17 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF FOOD CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 0- 7

 MEAN 24. 24. 23. 22. 22.*

 S.D. 1.6 2.4 1.7 2.2 1.4

 S.E. 0.5 0.7 0.5 0.6 0.4

 N 12 12 12 12 12

 DAY 7- 13

 MEAN 23. 24. 22. 23. 21.**

 S.D. 1.4 2.3 1.9 1.9 1.7

 S.E. 0.4 0.7 0.5 0.6 0.5

 N 12 12 12 12 12

-----------------------------------------------------------------------------------------------------------------------------------

* = Significantly different from the control group at 0.05 using Dunnett's test

** = Significantly different from the control group at 0.01 using Dunnett's test

 PJTFWSUv5.23

 11/25/2013

Page 93 of 1107
 TABLE S18 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF FOOD CONSUMPTION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 0- 7

 MEAN 63. 62. 60. 59. 59.

 S.D. 4.2 3.7 4.8 4.6 2.9

 S.E. 1.2 1.1 1.4 1.3 0.8

 N 12 12 12 12 12

 DAY 7- 13

 MEAN 59. 59. 55.* 58. 54.**

 S.D. 2.5 3.4 4.2 3.1 2.4

 S.E. 0.7 1.0 1.2 0.9 0.7

 N 12 12 12 12 12

-----------------------------------------------------------------------------------------------------------------------------------

* = Significantly different from the control group at 0.05 using Dunnett's test

** = Significantly different from the control group at 0.01 using Dunnett's test

 PJTFWSUv5.23

 11/25/2013

Page 94 of 1107
 TABLE S19 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF FOOD CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 0- 7

 MEAN 18. 17. 17. 17.* 16.*

 S.D. 1.8 1.2 1.9 1.6 0.9

 S.E. 0.5 0.3 0.5 0.5 0.3

 N 12 12 12 12 12

 DAY 7- 13

 MEAN 19. 18. 19. 19. 18.

 S.D. 1.6 1.7 1.8 1.8 1.2

 S.E. 0.5 0.5 0.5 0.5 0.3

 N 12 12 12 12 12

-----------------------------------------------------------------------------------------------------------------------------------

* = Significantly different from the control group at 0.05 using Dunnett's test

 PJTFWSUv5.23

 01/07/2014

Page 95 of 1107
 TABLE S20 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF FOOD CONSUMPTION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 0- 7

 MEAN 71. 68. 68. 64.** 65.*

 S.D. 5.5 2.3 5.1 7.0 3.5

 S.E. 1.6 0.7 1.5 2.0 1.0

 N 12 12 12 12 12

 DAY 7- 13

 MEAN 70. 67. 70. 68. 67.

 S.D. 4.0 5.1 3.4 4.6 4.3

 S.E. 1.2 1.5 1.0 1.3 1.2

 N 12 12 12 12 12

-----------------------------------------------------------------------------------------------------------------------------------

* = Significantly different from the control group at 0.05 using Dunnett's test

** = Significantly different from the control group at 0.01 using Dunnett's test

 PJTFWSUv5.23

 01/07/2014

Page 96 of 1107
 TABLE S21 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF FOOD CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 0- 4

 MEAN 20. 20. 19. 18.* 19.

 S.D. 1.7 1.6 2.6 1.8 2.5

 S.E. 0.5 0.5 0.7 0.5 0.7

 N 12 12 12 11 12

 DAY 4- 7

 MEAN 22. 22. 22. 21. 21.

 S.D. 2.2 1.5 2.6 2.6 2.6

 S.E. 0.6 0.4 0.7 0.8 0.7

 N 12 12 12 11 12

 DAY 7- 11

 MEAN 24. 23. 23. 22. 21.

 S.D. 2.3 2.1 2.0 2.7 2.3

 S.E. 0.7 0.6 0.6 0.8 0.7

 N 12 12 12 11 12

 DAY 11- 14

 MEAN 25. 24. 23. 23. 22.

 S.D. 2.2 0.7 2.6 2.3 2.2

 S.E. 0.6 0.2 0.7 0.7 0.6

 N 12 12 12 11 12

 DAY 14- 17

 MEAN 26. 25. 25. 25. 25.

 S.D. 2.4 1.9 2.6 2.1 2.4

 S.E. 0.7 0.5 0.7 0.6 0.7

 N 12 12 12 11 12

-----------------------------------------------------------------------------------------------------------------------------------

* = Significantly different from the control group at 0.05 using Dunnett's test

NONGRAVID WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 97 of 1107
 TABLE S21 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF FOOD CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 17- 20

 MEAN 26. 26. 26. 27. 25.

 S.D. 2.3 2.4 2.6 2.5 2.5

 S.E. 0.7 0.7 0.7 0.7 0.7

 N 12 12 12 11 12

 DAY 0- 20

 MEAN 24. 23. 23. 22. 22.

 S.D. 1.8 1.2 2.0 2.2 2.3

 S.E. 0.5 0.3 0.6 0.7 0.7

 N 12 12 12 11 12

-----------------------------------------------------------------------------------------------------------------------------------

None significantly different from control group

NONGRAVID WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

 PGFWSUv5.16

 01/07/2014

Page 98 of 1107
 TABLE S22 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF FOOD CONSUMPTION DURING GESTATION [G/KG/DAY]

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 0- 4

 MEAN 70. 69. 66. 60.** 66.

 S.D. 6.9 6.3 8.7 5.7 8.3

 S.E. 2.0 1.8 2.5 1.7 2.4

 N 12 12 12 11 12

 DAY 4- 7

 MEAN 72. 71. 73. 68. 70.

 S.D. 5.1 5.1 6.6 5.7 7.0

 S.E. 1.5 1.5 1.9 1.7 2.0

 N 12 12 12 11 12

 DAY 7- 11

 MEAN 73. 70. 70. 67. 68.

 S.D. 3.4 5.6 4.1 4.8 5.1

 S.E. 1.0 1.6 1.2 1.5 1.5

 N 12 12 12 11 12

 DAY 11- 14

 MEAN 71. 70. 68. 67. 68.

 S.D. 3.6 3.1 5.1 4.1 4.6

 S.E. 1.0 0.9 1.5 1.2 1.3

 N 12 12 12 11 12

 DAY 14- 17

 MEAN 71. 70. 70. 68. 71.

 S.D. 4.5 3.5 4.9 3.9 5.3

 S.E. 1.3 1.0 1.4 1.2 1.5

 N 12 12 12 11 12

-----------------------------------------------------------------------------------------------------------------------------------

** = Significantly different from the control group at 0.01 using Dunnett's test

NONGRAVID WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 99 of 1107
 TABLE S22 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF FOOD CONSUMPTION DURING GESTATION [G/KG/DAY]

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 17- 20

 MEAN 63. 66. 65. 67. 64.

 S.D. 3.5 4.1 4.5 4.2 5.6

 S.E. 1.0 1.2 1.3 1.3 1.6

 N 12 12 12 11 12

 DAY 0- 20

 MEAN 69. 68. 67. 65. 67.

 S.D. 3.2 2.7 4.0 4.3 5.6

 S.E. 0.9 0.8 1.2 1.3 1.6

 N 12 12 12 11 12

-----------------------------------------------------------------------------------------------------------------------------------

None significantly different from control group

NONGRAVID WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

 PGFWSUv5.16

 01/07/2014

Page 100 of 1107
 TABLE S23 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF FOOD CONSUMPTION DURING LACTATION [G/ANIMAL/DAY]

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1- 4

 MEAN 32. 30. 29. 28. 36.

 S.D. 6.7 5.1 8.1 6.4 4.7

 S.E. 1.9 1.5 2.3 2.0 1.4

 N 12 12 12 10 12

-----------------------------------------------------------------------------------------------------------------------------------

None significantly different from control group

 PLFWSUv5.22

 01/07/2014

Page 101 of 1107
 TABLE S24 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF FOOD CONSUMPTION DURING LACTATION [G/KG/DAY]

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1- 4

 MEAN 96. 92. 91. 83. 112.

 S.D. 19.1 14.0 22.2 16.5 15.6

 S.E. 5.5 4.0 6.4 5.2 4.5

 N 12 12 12 10 12

-----------------------------------------------------------------------------------------------------------------------------------

None significantly different from control group

 PLFWSUv5.22

 01/07/2014

Page 102 of 1107
 TABLE S25 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 0- 7

 MEAN 42. 40. 38. 45. 39.

 S.D. 8.6 7.9 6.0 11.2 7.6

 S.E. 2.5 2.3 1.7 3.2 2.2

 N 12 12 12 12 12

 DAY 7- 13

 MEAN 37. 38. 36. 41. 38.

 S.D. 4.7 4.2 4.4 7.4 6.9

 S.E. 1.4 1.2 1.3 2.1 2.0

 N 12 12 12 12 12

-----------------------------------------------------------------------------------------------------------------------------------

None significantly different from control group

 PJTFWSUv5.23

 01/20/2014

Page 103 of 1107
 TABLE S26 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF WATER CONSUMPTION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 0- 7

 MEAN 111. 104. 101. 119. 103.

 S.D. 21.9 19.1 16.4 31.3 18.0

 S.E. 6.3 5.5 4.7 9.0 5.2

 N 12 12 12 12 12

 DAY 7- 13

 MEAN 94. 93. 92. 105. 98.

 S.D. 11.6 9.6 11.5 19.6 14.7

 S.E. 3.4 2.8 3.3 5.7 4.3

 N 12 12 12 12 12

-----------------------------------------------------------------------------------------------------------------------------------

None significantly different from control group

 PJTFWSUv5.23

 01/20/2014

Page 104 of 1107
 TABLE S27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 0- 7

 MEAN 33. 33. 35. 37. 31.

 S.D. 6.1 7.4 5.7 7.0 4.8

 S.E. 1.7 2.1 1.6 2.0 1.4

 N 12 12 12 12 12

 DAY 7- 13

 MEAN 35. 35. 40. 38. 33.

 S.D. 6.6 8.9 7.2 5.4 3.9

 S.E. 1.9 2.6 2.1 1.6 1.1

 N 12 12 12 12 12

-----------------------------------------------------------------------------------------------------------------------------------

None significantly different from control group

 PJTFWSUv5.23

 01/16/2014

Page 105 of 1107
 TABLE S28 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF WATER CONSUMPTION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 0- 7

 MEAN 129. 132. 140. 143. 123.

 S.D. 23.5 32.9 24.3 26.6 21.7

 S.E. 6.8 9.5 7.0 7.7 6.3

 N 12 12 12 12 12

 DAY 7- 13

 MEAN 131. 130. 147. 138. 125.

 S.D. 26.3 37.8 28.8 17.4 17.7

 S.E. 7.6 10.9 8.3 5.0 5.1

 N 12 12 12 12 12

-----------------------------------------------------------------------------------------------------------------------------------

None significantly different from control group

 PJTFWSUv5.23

 01/16/2014

Page 106 of 1107
 TABLE S29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 0- 4

 MEAN 32. 34. 37. 38. 32.

 S.D. 3.1 5.3 7.8 5.8 3.5

 S.E. 0.9 1.5 2.2 1.7 1.0

 N 12 12 12 11 12

 DAY 4- 7

 MEAN 35. 36. 43.** 43.** 35.

 S.D. 3.1 6.0 6.9 5.9 3.9

 S.E. 0.9 1.7 2.0 1.8 1.1

 N 12 12 12 11 12

 DAY 7- 11

 MEAN 39. 37. 43. 46. 35.

 S.D. 7.0 6.3 6.9 7.7 3.6

 S.E. 2.0 1.8 2.0 2.3 1.0

 N 12 12 12 11 12

 DAY 11- 14

 MEAN 42. 42. 48. 52.** 41.

 S.D. 7.8 6.5 6.3 6.8 4.0

 S.E. 2.2 1.9 1.8 2.1 1.2

 N 12 12 12 11 12

 DAY 14- 17

 MEAN 47. 47. 53. 58.** 46.

 S.D. 8.9 7.9 6.4 8.3 5.1

 S.E. 2.6 2.3 1.8 2.5 1.5

 N 12 12 12 11 12

-----------------------------------------------------------------------------------------------------------------------------------

** = Significantly different from the control group at 0.01 using Dunnett's test

NONGRAVID WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 107 of 1107
 TABLE S29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 17- 20

 MEAN 46. 47. 51. 58.** 45.

 S.D. 5.9 6.9 5.3 9.0 4.0

 S.E. 1.7 2.0 1.5 2.7 1.2

 N 12 12 12 11 12

 DAY 0- 20

 MEAN 40. 40. 45. 48.** 39.

 S.D. 4.3 5.9 6.1 6.6 3.4

 S.E. 1.3 1.7 1.8 2.0 1.0

 N 12 12 12 11 12

-----------------------------------------------------------------------------------------------------------------------------------

** = Significantly different from the control group at 0.01 using Dunnett's test

NONGRAVID WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

 PGFWSUv5.16

 01/16/2014

Page 108 of 1107
 TABLE S30 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF WATER CONSUMPTION DURING GESTATION [G/KG/DAY]

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 0- 4

 MEAN 112. 118. 128. 126. 114.

 S.D. 13.6 21.9 31.1 18.0 13.6

 S.E. 3.9 6.3 9.0 5.4 3.9

 N 12 12 12 11 12

 DAY 4- 7

 MEAN 114. 119. 140.** 139.** 116.

 S.D. 11.7 23.0 25.3 14.7 13.9

 S.E. 3.4 6.6 7.3 4.4 4.0

 N 12 12 12 11 12

 DAY 7- 11

 MEAN 121. 115. 133. 139. 113.

 S.D. 23.4 22.3 22.4 17.7 13.4

 S.E. 6.8 6.4 6.5 5.3 3.9

 N 12 12 12 11 12

 DAY 11- 14

 MEAN 123. 124. 143. 152.** 126.

 S.D. 25.2 22.4 17.9 16.3 15.3

 S.E. 7.3 6.5 5.2 4.9 4.4

 N 12 12 12 11 12

 DAY 14- 17

 MEAN 129. 130. 147. 160.** 130.

 S.D. 23.8 23.9 17.5 18.8 17.7

 S.E. 6.9 6.9 5.0 5.7 5.1

 N 12 12 12 11 12

-----------------------------------------------------------------------------------------------------------------------------------

** = Significantly different from the control group at 0.01 using Dunnett's test

NONGRAVID WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 109 of 1107
 TABLE S30 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF WATER CONSUMPTION DURING GESTATION [G/KG/DAY]

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 17- 20

 MEAN 113. 118. 126. 143.** 116.

 S.D. 15.0 18.8 14.1 17.1 11.9

 S.E. 4.3 5.4 4.1 5.1 3.4

 N 12 12 12 11 12

 DAY 0- 20

 MEAN 117. 119. 133. 140.** 117.

 S.D. 14.5 20.2 19.9 14.3 12.6

 S.E. 4.2 5.8 5.7 4.3 3.6

 N 12 12 12 11 12

-----------------------------------------------------------------------------------------------------------------------------------

** = Significantly different from the control group at 0.01 using Dunnett's test

NONGRAVID WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

 PGFWSUv5.16

 01/16/2014

Page 110 of 1107
 TABLE S31 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF WATER CONSUMPTION DURING LACTATION [G/ANIMAL/DAY]

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1- 4

 MEAN 61. 48.* 48.* 46.** 51.

 S.D. 15.1 6.7 9.1 13.5 5.9

 S.E. 4.3 1.9 2.6 4.3 1.7

 N 12 12 12 10 12

-----------------------------------------------------------------------------------------------------------------------------------

* = Significantly different from the control group at 0.05 using Dunnett's test

** = Significantly different from the control group at 0.01 using Dunnett's test

 PLFWSUv5.22

 01/16/2014

Page 111 of 1107
 TABLE S32 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF WATER CONSUMPTION DURING LACTATION [G/KG/DAY]

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1- 4

 MEAN 183. 150. 148.* 139.** 160.

 S.D. 48.9 19.8 22.2 36.8 21.5

 S.E. 14.1 5.7 6.4 11.6 6.2

 N 12 12 12 10 12

-----------------------------------------------------------------------------------------------------------------------------------

* = Significantly different from the control group at 0.05 using Dunnett's test

** = Significantly different from the control group at 0.01 using Dunnett's test

 PLFWSUv5.22

 01/16/2014

Page 112 of 1107
 TABLE S33 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ESTROUS CYCLE DATA

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 ESTROUS CYCLE LENGTH (DAYS)

 MEAN 5.2 4.6 4.9 5.0 5.1

 S.D. 2.41 0.50 0.42 1.05 1.67

 S.E. 0.70 0.14 0.12 0.30 0.50

 N 12 12 12 12 11

-----------------------------------------------------------------------------------------------------------------------------------

None significantly different from control group

ESTROUS CYCLE LENGTH CALCULATED FOR FEMALES HAVING ONE FULL ESTROUS CYCLE

 PCYCv5.29

 01/07/2014

Page 113 of 1107
 TABLE S34 (F0)

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROMO-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF REPRODUCTIVE PERFORMANCE

----------------------------------------------------------------------------------------------------------------------------------

 DOSE GROUP 1 2 3 4 5

----------------------------------------------------------------------------------------------------------------------------------

 NO. % NO. % NO. % NO. % NO. %

MALES ON STUDY 12 12 12 12 12

 MALES THAT DIED 0 0 0 0 0

 MALES PAIRED FOR MATING 12 12 12 12 12

 MALES WITH EVIDENCE OF MATING 12 100.0 12 100.0 12 100.0 11 91.7 12 100.0

 NO. THAT SIRED A LITTER 12 100.0 12 100.0 12 100.0 11 100.0 12 100.0

 NO. THAT DID NOT SIRE A LITTER 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0

 MALES WITH NO EVIDENCE OF MATING 0 0.0 0 0.0 0 0.0 1 8.3 0 0.0

 NO. THAT SIRED A LITTER NA NA NA 0 0.0 NA

 NO. THAT DID NOT SIRE A LITTER NA NA NA 1 100.0 NA

----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

 NOTE: MALES WERE CONSIDERED TO HAVE SIRED A LITTER IF THE PAIRED FEMALE WAS GRAVID

 NOTE: POSITIVE EVIDENCE OF MATING DURING THE BREEDING PERIOD WAS CONFIRMED BY THE PRESENCE OF SPERM IN A VAGINAL LAVAGE

 OR A VAGINAL COPULATORY PLUG

 NA = NOT APPLICABLE

Page 114 of 1107
 TABLE S34 (F0)

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROMO-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF REPRODUCTIVE PERFORMANCE

----------------------------------------------------------------------------------------------------------------------------------

 DOSE GROUP 1 2 3 4 5

----------------------------------------------------------------------------------------------------------------------------------

 NO. % NO. % NO. % NO. % NO. %

 FEMALES ON STUDY 12 12 12 12 12

 FEMALES THAT DIED 0 0 0 0 0

 FEMALES PAIRED FOR MATING 12 12 12 12 12

 NONGRAVID 0 0.0 0 0.0 0 0.0 1 8.3 0 0.0

 GRAVID 12 100.0 12 100.0 12 100.0 11 91.7 12 100.0

 DELIVERED 12 100.0 12 100.0 12 100.0 11 100.0 12 100.0

 FEMALES WITH TOTAL LITTER LOSS 0 0.0 0 0.0 0 0.0 1 9.1 0 0.0

 FEMALES WITH VIABLE PUPS 12 100.0 12 100.0 12 100.0 10 90.9 12 100.0

 FAILED TO DELIVER 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0

 FEMALES WITH EVIDENCE OF MATING 12 100.0 12 100.0 12 100.0 11 91.7 12 100.0

 NO. GRAVID 12 100.0 12 100.0 12 100.0 11 100.0 12 100.0

 NO. NONGRAVID 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0

 FEMALES WITH NO EVIDENCE OF MATING 0 0.0 0 0.0 0 0.0 1 8.3 0 0.0

 NO. GRAVID NA NA NA 0 0.0 NA

 NO. NONGRAVID NA NA NA 1 100.0 NA

 TOTAL FEMALES GRAVID 12 100.0 12 100.0 12 100.0 11 91.7 12 100.0

----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

 NOTE: POSITIVE EVIDENCE OF MATING DURING THE BREEDING PERIOD WAS CONFIRMED BY THE PRESENCE OF SPERM IN A VAGINAL LAVAGE

 OR A VAGINAL COPULATORY PLUG.

 NA = NOT APPLICABLE

Page 115 of 1107
 TABLE S34 (F0)

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROMO-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF REPRODUCTIVE PERFORMANCE

----------------------------------------------------------------------------------------------------------------------------------

 DOSE GROUP 1 2 3 4 5

----------------------------------------------------------------------------------------------------------------------------------

 NO. % NO. % NO. % NO. % NO. %

MALE MATING INDEX 12/12 100.0 12/12 100.0 12/12 100.0 11/12 91.7 12/12 100.0

FEMALE MATING INDEX 12/12 100.0 12/12 100.0 12/12 100.0 11/12 91.7 12/12 100.0

MALE FERTILITY INDEX 12/12 100.0 12/12 100.0 12/12 100.0 11/12 91.7 12/12 100.0

FEMALE FERTILITY INDEX 12/12 100.0 12/12 100.0 12/12 100.0 11/12 91.7 12/12 100.0

MALE COPULATION INDEX 12/12 100.0 12/12 100.0 12/12 100.0 11/11 100.0 12/12 100.0

FEMALE CONCEPTION INDEX 12/12 100.0 12/12 100.0 12/12 100.0 11/11 100.0 12/12 100.0

MEAN PRE-COITAL INTERVALS

 DAYS 2.9 NA 2.9 NA 2.4 NA 4.5 NA 2.0 NA

 S.D. 1.16 NA 1.62 NA 1.62 NA 3.78 NA 1.04 NA

 S.E. 0.34 NA 0.47 NA 0.47 NA 1.14 NA 0.30 NA

 N 12 NA 12 NA 12 NA 11 NA 12 NA

 NO. OF MALES (FEMALES) WITH EVIDENCE OF MATING (OR CONFIRMED PREGNANCY)

 MALE (FEMALE) MATING INDEX (%) = ---------------------------------------------------------------------- X 100

 TOTAL NO. OF MALES (FEMALES) USED FOR MATING

 NO. OF MALES SIRING A LITTER

 MALE FERTILITY INDEX (%) = ----------------------------------------- X 100

 TOTAL NO. OF MALES USED FOR MATING

 NO. OF FEMALES WITH CONFIRMED PREGNANCY

 FEMALE FERTILITY INDEX (%) = ---------------------------------------- X 100

 TOTAL NO. OF FEMALES USED FOR MATING

 NO. OF MALES SIRING A LITTER

 MALE COPULATION INDEX (%) = ---------------------------------------------------------------------- X 100

 NO. OF MALES WITH EVIDENCE OF MATING (OR FEMALES CONFIRMED PREGNANT)

 NO. OF FEMALES WITH CONFIRMED PREGNANCY

 FEMALE CONCEPTION INDEX (%) = ----------------------------------------------------------------- X 100

 NO. OF FEMALES WITH EVIDENCE OF MATING (OR CONFIRMED PREGNANCY)

---------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

PRE-COITAL INTERVALS NOT SIGNIFICANTLY DIFFERENT FROM CONTROL GROUP USING DUNNETT'S TEST

MATING, FERTILITY AND COPULATION/CONCEPTION INDICES NOT SIGNIFICANTLY DIFFERENT FROM CONTROL GROUP USING CHI-SQUARE TEST

NA = NOT APPLICABLE

 MANUALv1.0

 12/13/2013

 R:01/20/2014

Page 116 of 1107
 TABLE S35 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF GESTATION LENGTHS [DAYS]

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 GESTATION LENGTH (DAYS)

 MEAN 21.7 22.1 22.3** 22.6** 22.1

 S.D. 0.49 0.29 0.49 0.50 0.29

 S.E. 0.14 0.08 0.14 0.15 0.08

 N 12 12 12 11 12

-----------------------------------------------------------------------------------------------------------------------------------

** = Significantly different from the control group at 0.01 using Dunnett's test

 PGLv5.10

 01/07/2014

Page 117 of 1107
 TABLE S36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF PARTURITION FINDINGS: TOTAL OCCURRENCE/NO. OF FEMALES

CATEGORY

 FINDING GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

PARTURITION OBS

 NO PRE-DELIVERY FINDINGS 47/ 12 60/ 12 62/ 12 99/ 12 58/ 12

 VAGINAL DISCHARGE/MATERIAL 0/ 0 0/ 0 2/ 2 2/ 2 0/ 0

 PUPS PRESENT IN NESTING BOX 12/ 12 12/ 12 12/ 12 11/ 11 12/ 12

 NO SIGNIFICANT FINDINGS DURING PARTURITION 17/ 12 16/ 12 14/ 12 15/ 11 13/ 12

-----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

 PPOCRDv1.05

 01/07/2014

Page 118 of 1107
 TABLE S37 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF SPERM MOTILITY AND CONCENTRATION

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 MOTILITY (%)

 MEAN 77. 75. 74. 80. 77.

 S.D. 6.5 5.5 7.8 4.9 9.8

 S.E. 1.9 1.6 2.2 1.4 2.8

 N 12 12 12 12 12

 PROGRESSIVE MOTILITY (%)

 MEAN 59. 60. 59. 63. 61.

 S.D. 7.6 6.4 7.7 5.6 9.4

 S.E. 2.2 1.8 2.2 1.6 2.7

 N 12 12 12 12 12

 CAUDA EPID, LT WEIGHT (GRAMS)

 MEAN 0.2824 0.2950 0.2784 0.2789 0.2791

 S.D. 0.01902 0.02576 0.02161 0.02832 0.02835

 S.E. 0.00549 0.00744 0.00624 0.00817 0.00819

 N 12 12 12 12 12

 CAUDA EPID, LT CONCENTRATION (MILLIONS/GRAM)

 MEAN 663.7 635.8 647.6 596.0 627.5

 S.D. 165.40 161.90 140.33 191.92 207.96

 S.E. 47.75 46.74 40.51 55.40 60.03

 N 12 12 12 12 12

 TESTIS, LT WEIGHT (GRAMS)

 MEAN 1.65 1.69 1.66 1.66 1.67

 S.D. 0.076 0.119 0.136 0.115 0.140

 S.E. 0.022 0.034 0.039 0.033 0.040

 N 12 12 12 12 12

 TESTIS, LT CONCENTRATION (MILLIONS/GRAM)

 MEAN 100.3 100.0 103.5 105.5 97.9

 S.D. 13.34 22.38 15.80 17.04 12.00

 S.E. 3.85 6.46 4.56 4.92 3.46

 N 12 12 12 12 12

-----------------------------------------------------------------------------------------------------------------------------------

MODIFIED STATISTICS USED. * INDICATES PARAMETRIC ANALYSIS AND + INDICATES NON-PARAMETRIC ANALYSIS.

None significantly different from control group

Page 119 of 1107
 TABLE S37 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF SPERM MOTILITY AND CONCENTRATION

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 SPERM PRODUCTION RATE (MILLIONS/GRAM/DAY)

 MEAN 16.4 16.4 17.0 17.3 16.1

 S.D. 2.19 3.67 2.59 2.79 1.97

 S.E. 0.63 1.06 0.75 0.81 0.57

 N 12 12 12 12 12

-----------------------------------------------------------------------------------------------------------------------------------

MODIFIED STATISTICS USED. * INDICATES PARAMETRIC ANALYSIS AND + INDICATES NON-PARAMETRIC ANALYSIS.

None significantly different from control group

 PDIVOSv4.30

 01/20/2014

Page 120 of 1107
 TABLE S38 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF SPERM MORPHOLOGY DIFFERENTIAL COUNTS [PERCENTAGE]

-----------------------------------------------------------------------------------------------------------------------------------

 ----- M A L E -----

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 NORMAL

 MEAN 99.0 100.0 99.3 99.9 99.4

 S.D. 1.75 0.14 1.34 0.23 0.83

 S.E. 0.51 0.04 0.39 0.07 0.24

 N 12 12 12 12 12

 NORMALLY SHAPED HEAD

 SEPARATED FROM FLAGELLUM

 MEAN 0.7 0.0 0.4 0.0 0.3

 S.D. 1.45 0.14 0.74 0.00 0.62

 S.E. 0.42 0.04 0.21 0.00 0.18

 N 12 12 12 12 12

 HEAD ABSENT WITH NORMAL FLAGELLUM

 MEAN 0.3 0.0 0.3 0.1 0.3

 S.D. 0.45 0.00 0.62 0.23 0.49

 S.E. 0.13 0.00 0.18 0.07 0.14

 N 12 12 12 12 12

 HEAD ABSENT WITH ABNORMAL FLAGELLUM

 MEAN 0.0 0.0 0.0 0.0 0.0

 S.D. 0.00 0.00 0.00 0.00 0.00

 S.E. 0.00 0.00 0.00 0.00 0.00

 N 12 12 12 12 12

 MISSHAPEN HEAD WITH NORMAL FLAGELLUM

 MEAN 0.0 0.0 0.0 0.0 0.0

 S.D. 0.00 0.00 0.00 0.00 0.00

 S.E. 0.00 0.00 0.00 0.00 0.00

 N 12 12 12 12 12

-----------------------------------------------------------------------------------------------------------------------------------

MODIFIED STATISTICS USED.

Percent of normal sperm not significantly different from control group

Page 121 of 1107
 TABLE S38 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF SPERM MORPHOLOGY DIFFERENTIAL COUNTS [PERCENTAGE]

-----------------------------------------------------------------------------------------------------------------------------------

 ----- M A L E -----

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 MISSHAPEN HEAD WITH ABNORMAL FLAGELLUM

 MEAN 0.0 0.0 0.0 0.0 0.0

 S.D. 0.00 0.00 0.00 0.00 0.00

 S.E. 0.00 0.00 0.00 0.00 0.00

 N 12 12 12 12 12

 FLAGELLAR DEFECTS WITH NORMAL HEAD

 MEAN 0.0 0.0 0.0 0.0 0.0

 S.D. 0.00 0.00 0.00 0.00 0.00

 S.E. 0.00 0.00 0.00 0.00 0.00

 N 12 12 12 12 12

-----------------------------------------------------------------------------------------------------------------------------------

 MANUALv1.0

 11/14/2013

 R:01/20/2014

Page 122 of 1107
 TABLE S39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF MACROSCOPIC FINDINGS

 SCHEDULED NECROPSY

-----------------------------------------------------------------------------------------------------------------------------------

 ----- M A L E -----

 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NUMBER OF ANIMALS EXAMINED 12 12 12 12 12

KIDNEYS

-DILATED PELVIS 1 1 0 0 1

-AREA(S), DEPRESSED 0 0 0 1 1

LN, MANDIBULAR

-ENLARGED 0 0 0 0 1

SKIN

-MATTING, RED 0 0 1 0 0

SPLEEN

-AREA(S), WHITE 0 0 0 1 0

TEETH

-MALALIGNED 0 0 1 0 0

NO SIGNIFICANT CHANGES OBSERVED - ALL EXAMINED TISSUES 11 11 11 10 9

-----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

 PGRSI2v4.11

 02/18/2014

Page 123 of 1107
 TABLE S40 (F0 FEMALES - FAILED TO DELIVER)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF MACROSCOPIC FINDINGS

 SCHEDULED NECROPSY

-----------------------------------------------------------------------------------------------------------------------------------

 ----- F E M A L E -----

 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NUMBER OF ANIMALS EXAMINED 0 0 0 1 0

UTERUS

-CONTENTS, CLEAR FLUID 0 0 0 1 0

-----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

 PGRSI2v4.11

 02/18/2014

Page 124 of 1107
 TABLE S41 (F0 FEMALES - TOTAL LITTER LOSS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF MACROSCOPIC FINDINGS

 SCHEDULED NECROPSY

-----------------------------------------------------------------------------------------------------------------------------------

 ----- F E M A L E -----

 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NUMBER OF ANIMALS EXAMINED 0 0 0 1 0

NO SIGNIFICANT CHANGES OBSERVED - ALL EXAMINED TISSUES 0 0 0 1 0

-----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

 PGRSI2v4.11

 02/18/2014

Page 125 of 1107
 TABLE S42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF MACROSCOPIC FINDINGS

 SCHEDULED NECROPSY

-----------------------------------------------------------------------------------------------------------------------------------

 ----- F E M A L E -----

 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NUMBER OF ANIMALS EXAMINED 12 12 12 10 12

KIDNEYS

-PALE 0 1 0 0 0

SPLEEN

-ADHESIONS 0 0 1 1 0

NO SIGNIFICANT CHANGES OBSERVED - ALL EXAMINED TISSUES 12 11 11 9 12

-----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

 PGRSI2v4.11

 02/18/2014

Page 126 of 1107
 TABLE S43 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF CORPORA LUTEA AND IMPLANTATION SITES

-----------------------------------------------------------------------------------------------------------------------------------

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 IMPLANTATION SITES

 MEAN 15.8 14.3 14.4 15.3 15.1

 S.D. 1.19 1.83 2.75 1.74 0.94

 S.E. 0.34 0.53 0.79 0.52 0.28

 N 12 12 12 11 11-A

 NUMBER BORN

 MEAN 14.3 13.8 13.7 13.3 13.9

 S.D. 1.78 2.12 2.96 2.10 1.24

 S.E. 0.51 0.61 0.86 0.63 0.36

 N 12 12 12 11 12

 UNACCOUNTED SITES

 MEAN 1.5 0.5 0.8 2.0 1.1

 S.D. 1.93 0.80 1.14 1.26 1.30

 S.E. 0.56 0.23 0.33 0.38 0.39

 N 12 12 12 11 11-A

 CORPORA LUTEA

 MEAN 16.5 15.3 15.8 16.2 16.4

 S.D. 1.62 1.30 1.29 1.89 1.63

 S.E. 0.47 0.38 0.37 0.57 0.49

 N 12 12 12 11 11-A

-----------------------------------------------------------------------------------------------------------------------------------

None significantly different from control group

NOTE: ONLY DAMS THAT HAVE DELIVERED ONE OR MORE PUPS ARE INCLUDED IN CALCULATION OF MEAN.

A = NUMBER OF PUPS BORN EXCEEDED NUMBER OF IMPLANTATION SITES FOR 1 FEMALE; NOT INCLUDED IN CALCULATION OF MEAN.

 PISSUv5.12

 01/07/2014

 R:01/21/2014

Page 127 of 1107
 TABLE S44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 FINAL BODY WT (G)

 MEAN 450. 456. 431. 438. 418.*

 % DIFFERENCE 1.3 -4.2 -2.7 -7.1

 S.D. 27.2 32.3 18.1 21.4 23.8

 S.E. 7.9 9.3 5.2 6.2 6.9

 N 12 12 12 12 12

 BRAIN (G)

 MEAN 2.12 2.04 2.05 2.02 2.05

 % DIFFERENCE -3.8 -3.3 -4.7 -3.3

 S.D. 0.104 0.107 0.069 0.073 0.107

 S.E. 0.030 0.031 0.020 0.021 0.031

 N 12 12 12 12 12

 BRAIN (G/100 G FINAL BODY WEIGHT)

 MEAN 0.472 0.449 0.476 0.461 0.490

 S.D. 0.0173 0.0329 0.0240 0.0244 0.0331

 S.E. 0.0050 0.0095 0.0069 0.0070 0.0096

 N 12 12 12 12 12

 CAUDA EPID, LT (G)

 MEAN 0.2824 0.2950 0.2784 0.2789 0.2791

 % DIFFERENCE 4.5 -1.4 -1.2 -1.2

 S.D. 0.01902 0.02576 0.02161 0.02832 0.02835

 S.E. 0.00549 0.00744 0.00624 0.00817 0.00819

 N 12 12 12 12 12

-----------------------------------------------------------------------------------------------------------------------------------

* = Significantly different from the control group at 0.05 using Dunnett's test

Page 128 of 1107
 TABLE S44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 CAUDA EPID, LT (G/100 G FINAL BODY WEIGHT)

 MEAN 0.063 0.065 0.065 0.064 0.067

 S.D. 0.0045 0.0053 0.0049 0.0054 0.0083

 S.E. 0.0013 0.0015 0.0014 0.0016 0.0024

 N 12 12 12 12 12

 CAUDA EPID, LT (G/100 G BRAIN)

 MEAN 13.318 14.483 13.629 13.851 13.697

 S.D. 0.8245 1.1513 1.1505 1.4427 1.6613

 S.E. 0.2380 0.3324 0.3321 0.4165 0.4796

 N 12 12 12 12 12

 CAUDA EPID, RT (G)

 MEAN 0.2741 0.2825 0.2679 0.2679 0.2640

 % DIFFERENCE 3.1 -2.3 -2.3 -3.7

 S.D. 0.01689 0.02346 0.02547 0.02396 0.02522

 S.E. 0.00488 0.00677 0.00735 0.00692 0.00728

 N 12 12 12 12 12

 CAUDA EPID, RT (G/100 G FINAL BODY WEIGHT)

 MEAN 0.061 0.062 0.062 0.061 0.063

 S.D. 0.0057 0.0056 0.0063 0.0049 0.0057

 S.E. 0.0016 0.0016 0.0018 0.0014 0.0016

 N 12 12 12 12 12

-----------------------------------------------------------------------------------------------------------------------------------

None significantly different from control group

Page 129 of 1107
 TABLE S44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 CAUDA EPID, RT (G/100 G BRAIN)

 MEAN 12.944 13.878 13.097 13.305 12.918

 S.D. 1.0209 1.1520 1.1461 1.2467 1.1101

 S.E. 0.2947 0.3326 0.3309 0.3599 0.3204

 N 12 12 12 12 12

 EPIDIDYMIS, LT (G)

 MEAN 0.59 0.62 0.59 0.61 0.60

 % DIFFERENCE 5.1 0.0 3.4 1.7

 S.D. 0.043 0.046 0.041 0.043 0.046

 S.E. 0.012 0.013 0.012 0.012 0.013

 N 12 12 12 12 12

 EPIDIDYMIS, LT (G/100 G FINAL BODY WEIGHT)

 MEAN 0.131 0.135 0.137 0.139 0.144**

 S.D. 0.0090 0.0090 0.0104 0.0078 0.0131

 S.E. 0.0026 0.0026 0.0030 0.0023 0.0038

 N 12 12 12 12 12

 EPIDIDYMIS, LT (G/100 G BRAIN)

 MEAN 27.809 30.280 28.804 30.271 29.501

 S.D. 1.6660 2.6216 2.3345 2.4427 2.8392

 S.E. 0.4809 0.7568 0.6739 0.7051 0.8196

 N 12 12 12 12 12

-----------------------------------------------------------------------------------------------------------------------------------

** = Significantly different from the control group at 0.01 using Dunnett's test

Page 130 of 1107
 TABLE S44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 EPIDIDYMIS, RT (G)

 MEAN 0.64 0.65 0.63 0.64 0.64

 % DIFFERENCE 1.6 -1.6 0.0 0.0

 S.D. 0.037 0.045 0.047 0.044 0.061

 S.E. 0.011 0.013 0.013 0.013 0.018

 N 12 12 12 12 12

 EPIDIDYMIS, RT (G/100 G FINAL BODY WEIGHT)

 MEAN 0.142 0.143 0.147 0.145 0.153

 S.D. 0.0107 0.0089 0.0119 0.0066 0.0157

 S.E. 0.0031 0.0026 0.0034 0.0019 0.0045

 N 12 12 12 12 12

 EPIDIDYMIS, RT (G/100 G BRAIN)

 MEAN 30.121 32.081 30.897 31.584 31.224

 S.D. 1.9371 2.6131 2.1427 2.3623 3.0796

 S.E. 0.5592 0.7543 0.6186 0.6819 0.8890

 N 12 12 12 12 12

 KIDNEYS (G)

 MEAN 3.39 3.38 3.24 3.34 3.17

 % DIFFERENCE -0.3 -4.4 -1.5 -6.5

 S.D. 0.118 0.353 0.212 0.258 0.278

 S.E. 0.034 0.102 0.061 0.075 0.080

 N 12 12 12 12 12

-----------------------------------------------------------------------------------------------------------------------------------

None significantly different from control group

Page 131 of 1107
 TABLE S44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 KIDNEYS (G/100 G FINAL BODY WEIGHT)

 MEAN 0.755 0.743 0.754 0.764 0.759

 S.D. 0.0484 0.0584 0.0470 0.0496 0.0709

 S.E. 0.0140 0.0169 0.0136 0.0143 0.0205

 N 12 12 12 12 12

 KIDNEYS (G/100 G BRAIN)

 MEAN 159.754 166.352 158.858 166.229 154.983

 S.D. 7.0004 18.7974 13.0893 15.4138 13.8028

 S.E. 2.0209 5.4263 3.7786 4.4496 3.9845

 N 12 12 12 12 12

 LIVER (G)

 MEAN 15.81 16.38 15.30 15.57 14.44

 % DIFFERENCE 3.6 -3.2 -1.5 -8.7

 S.D. 1.142 2.090 1.107 1.142 1.426

 S.E. 0.330 0.603 0.320 0.330 0.412

 N 12 12 12 12 12

 LIVER (G/100 G FINAL BODY WEIGHT)

 MEAN 3.519 3.585 3.552 3.558 3.459

 S.D. 0.2123 0.2602 0.2047 0.1560 0.3457

 S.E. 0.0613 0.0751 0.0591 0.0450 0.0998

 N 12 12 12 12 12

-----------------------------------------------------------------------------------------------------------------------------------

None significantly different from control group

Page 132 of 1107
 TABLE S44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 LIVER (G/100 G BRAIN)

 MEAN 746.024 803.905 748.759 773.142 708.137

 S.D. 56.6688 98.5677 60.6455 54.1115 83.4066

 S.E. 16.3589 28.4540 17.5068 15.6206 24.0774

 N 12 12 12 12 12

 LUNGS (G)

 MEAN 1.66 1.71 1.69 1.80 1.64

 % DIFFERENCE 3.0 1.8 8.4 -1.2

 S.D. 0.165 0.170 0.102 0.162 0.153

 S.E. 0.048 0.049 0.029 0.047 0.044

 N 12 12 12 12 12

 LUNGS (G/100 G FINAL BODY WEIGHT)

 MEAN 0.369 0.377 0.393 0.412** 0.392

 S.D. 0.0283 0.0392 0.0288 0.0381 0.0260

 S.E. 0.0082 0.0113 0.0083 0.0110 0.0075

 N 12 12 12 12 12

 LUNGS (G/100 G BRAIN)

 MEAN 78.054 84.096 82.718 89.466** 80.426

 S.D. 5.7074 8.5177 6.6306 8.6495 7.8793

 S.E. 1.6476 2.4588 1.9141 2.4969 2.2746

 N 12 12 12 12 12

-----------------------------------------------------------------------------------------------------------------------------------

** = Significantly different from the control group at 0.01 using Dunnett's test

Page 133 of 1107
 TABLE S44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 PITUITARY (G)

 MEAN 0.0156 0.0146 0.0126** 0.0127** 0.0133*

 % DIFFERENCE -6.4 -19.2 -18.6 -14.7

 S.D. 0.00314 0.00203 0.00139 0.00113 0.00151

 S.E. 0.00091 0.00059 0.00040 0.00033 0.00044

 N 12 12 12 12 12

 PITUITARY (G/100 G FINAL BODY WEIGHT)

 MEAN 0.003 0.003 0.003** 0.003** 0.003

 S.D. 0.0007 0.0004 0.0003 0.0002 0.0004

 S.E. 0.0002 0.0001 0.0001 0.0001 0.0001

 N 12 12 12 12 12

 PITUITARY (G/100 G BRAIN)

 MEAN 0.735 0.713 0.615** 0.632* 0.651

 S.D. 0.1383 0.0795 0.0629 0.0595 0.0694

 S.E. 0.0399 0.0230 0.0182 0.0172 0.0200

 N 12 12 12 12 12

 SPLEEN (G)

 MEAN 0.82 0.84 0.76 0.77 0.74

 % DIFFERENCE 2.4 -7.3 -6.1 -9.8

 S.D. 0.114 0.125 0.053 0.109 0.087

 S.E. 0.033 0.036 0.015 0.031 0.025

 N 12 12 12 12 12

-----------------------------------------------------------------------------------------------------------------------------------

* = Significantly different from the control group at 0.05 using Dunnett's test

** = Significantly different from the control group at 0.01 using Dunnett's test

Page 134 of 1107
 TABLE S44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 SPLEEN (G/100 G FINAL BODY WEIGHT)

 MEAN 0.181 0.183 0.177 0.177 0.176

 S.D. 0.0170 0.0199 0.0130 0.0217 0.0156

 S.E. 0.0049 0.0057 0.0037 0.0063 0.0045

 N 12 12 12 12 12

 SPLEEN (G/100 G BRAIN)

 MEAN 38.470 40.976 37.175 38.388 35.910

 S.D. 4.5124 5.1303 2.4830 5.2915 3.3728

 S.E. 1.3026 1.4810 0.7168 1.5275 0.9736

 N 12 12 12 12 12

 TESTIS, LT (G)

 MEAN 1.65 1.69 1.66 1.66 1.67

 % DIFFERENCE 2.4 0.6 0.6 1.2

 S.D. 0.076 0.119 0.136 0.115 0.140

 S.E. 0.022 0.034 0.039 0.033 0.040

 N 12 12 12 12 12

 TESTIS, LT (G/100 G FINAL BODY WEIGHT)

 MEAN 0.368 0.371 0.387 0.380 0.401

 S.D. 0.0224 0.0274 0.0315 0.0256 0.0382

 S.E. 0.0065 0.0079 0.0091 0.0074 0.0110

 N 12 12 12 12 12

-----------------------------------------------------------------------------------------------------------------------------------

None significantly different from control group

Page 135 of 1107
 TABLE S44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 TESTIS, LT (G/100 G BRAIN)

 MEAN 77.837 82.964 81.410 82.467 81.976

 S.D. 3.8177 8.2986 7.0243 6.7831 7.3653

 S.E. 1.1021 2.3956 2.0278 1.9581 2.1262

 N 12 12 12 12 12

 TESTIS, RT (G)

 MEAN 1.67 1.69 1.67 1.69 1.71

 % DIFFERENCE 1.2 0.0 1.2 2.4

 S.D. 0.092 0.125 0.123 0.111 0.133

 S.E. 0.027 0.036 0.035 0.032 0.038

 N 12 12 12 12 12

 TESTIS, RT (G/100 G FINAL BODY WEIGHT)

 MEAN 0.372 0.371 0.388 0.385 0.409**

 S.D. 0.0267 0.0295 0.0289 0.0215 0.0347

 S.E. 0.0077 0.0085 0.0083 0.0062 0.0100

 N 12 12 12 12 12

 TESTIS, RT (G/100 G BRAIN)

 MEAN 78.699 83.086 81.818 83.698 83.594

 S.D. 4.4258 8.3680 6.4261 5.9026 6.8837

 S.E. 1.2776 2.4156 1.8551 1.7039 1.9871

 N 12 12 12 12 12

-----------------------------------------------------------------------------------------------------------------------------------

** = Significantly different from the control group at 0.01 using Dunnett's test

 POFBSTv5.26

 11/25/2013

 R:01/17/2014

Page 136 of 1107
 TABLE S45 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 FINAL BODY WT (G)

 MEAN 342. 327. 326. 337. 326.

 % DIFFERENCE -4.4 -4.7 -1.5 -4.7

 S.D. 22.6 23.5 28.3 33.2 17.9

 S.E. 6.5 6.8 8.2 10.5 5.2

 N 12 12 12 10 12

 BRAIN (G)

 MEAN 1.98 1.96 1.92 1.99 1.97

 % DIFFERENCE -1.0 -3.0 0.5 -0.5

 S.D. 0.056 0.094 0.060 0.085 0.081

 S.E. 0.016 0.027 0.017 0.027 0.023

 N 12 12 12 10 12

 BRAIN (G/100 G FINAL BODY WEIGHT)

 MEAN 0.580 0.600 0.595 0.594 0.606

 S.D. 0.0307 0.0424 0.0550 0.0452 0.0335

 S.E. 0.0089 0.0122 0.0159 0.0143 0.0097

 N 12 12 12 10 12

 KIDNEYS (G)

 MEAN 2.31 2.30 2.25 2.33 2.25

 % DIFFERENCE -0.4 -2.6 0.9 -2.6

 S.D. 0.094 0.194 0.254 0.186 0.282

 S.E. 0.027 0.056 0.073 0.059 0.081

 N 12 12 12 10 12

-----------------------------------------------------------------------------------------------------------------------------------

None significantly different from control group

Page 137 of 1107
 TABLE S45 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 KIDNEYS (G/100 G FINAL BODY WEIGHT)

 MEAN 0.675 0.704 0.690 0.694 0.689

 S.D. 0.0460 0.0411 0.0463 0.0564 0.0745

 S.E. 0.0133 0.0119 0.0134 0.0178 0.0215

 N 12 12 12 10 12

 KIDNEYS (G/100 G BRAIN)

 MEAN 116.444 117.941 116.960 117.325 114.155

 S.D. 4.4814 10.8749 14.2743 11.2889 14.4209

 S.E. 1.2937 3.1393 4.1206 3.5699 4.1630

 N 12 12 12 10 12

 LIVER (G)

 MEAN 14.57 13.81 13.58 14.44 13.66

 % DIFFERENCE -5.2 -6.8 -0.9 -6.2

 S.D. 1.569 1.384 1.366 1.153 0.922

 S.E. 0.453 0.399 0.394 0.365 0.266

 N 12 12 12 10 12

 LIVER (G/100 G FINAL BODY WEIGHT)

 MEAN 4.254 4.217 4.173 4.296 4.185

 S.D. 0.3456 0.2451 0.2540 0.1690 0.1934

 S.E. 0.0998 0.0708 0.0733 0.0535 0.0558

 N 12 12 12 10 12

-----------------------------------------------------------------------------------------------------------------------------------

None significantly different from control group

Page 138 of 1107
 TABLE S45 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 LIVER (G/100 G BRAIN)

 MEAN 735.127 706.773 706.734 725.824 692.981

 S.D. 67.2134 66.6586 77.3444 42.2679 52.1833

 S.E. 19.4028 19.2427 22.3274 13.3663 15.0640

 N 12 12 12 10 12

 LUNGS (G)

 MEAN 1.46 1.53 1.50 1.54 1.44

 % DIFFERENCE 4.8 2.7 5.5 -1.4

 S.D. 0.152 0.145 0.146 0.087 0.118

 S.E. 0.044 0.042 0.042 0.027 0.034

 N 12 12 12 10 12

 LUNGS (G/100 G FINAL BODY WEIGHT)

 MEAN 0.429 0.469 0.462 0.461 0.441

 S.D. 0.0471 0.0375 0.0470 0.0430 0.0323

 S.E. 0.0136 0.0108 0.0136 0.0136 0.0093

 N 12 12 12 10 12

 LUNGS (G/100 G BRAIN)

 MEAN 73.944 78.495 77.949 77.709 72.862

 S.D. 7.3575 7.0716 7.5488 4.9928 4.9068

 S.E. 2.1239 2.0414 2.1791 1.5789 1.4165

 N 12 12 12 10 12

-----------------------------------------------------------------------------------------------------------------------------------

None significantly different from control group

Page 139 of 1107
 TABLE S45 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 OVARIES (G)

 MEAN 0.1258 0.1142 0.1192 0.1176 0.1221

 % DIFFERENCE -9.2 -5.2 -6.5 -2.9

 S.D. 0.02109 0.01667 0.01521 0.01819 0.02475

 S.E. 0.00609 0.00481 0.00439 0.00575 0.00715

 N 12 12 12 10 12

 OVARIES (G/100 G FINAL BODY WEIGHT)

 MEAN 0.037 0.035 0.037 0.035 0.037

 S.D. 0.0046 0.0059 0.0046 0.0042 0.0071

 S.E. 0.0013 0.0017 0.0013 0.0013 0.0020

 N 12 12 12 10 12

 OVARIES (G/100 G BRAIN)

 MEAN 6.345 5.825 6.196 5.915 6.191

 S.D. 0.9988 0.6364 0.7677 0.9187 1.2287

 S.E. 0.2883 0.1837 0.2216 0.2905 0.3547

 N 12 12 12 10 12

 PITUITARY (G)

 MEAN 0.0207 0.0190 0.0156** 0.0175* 0.0175*

 % DIFFERENCE -8.2 -24.6 -15.5 -15.5

 S.D. 0.00310 0.00164 0.00257 0.00403 0.00177

 S.E. 0.00089 0.00047 0.00074 0.00127 0.00051

 N 12 12 12 10 12

-----------------------------------------------------------------------------------------------------------------------------------

* = Significantly different from the control group at 0.05 using Dunnett's test

** = Significantly different from the control group at 0.01 using Dunnett's test

Page 140 of 1107
 TABLE S45 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 PITUITARY (G/100 G FINAL BODY WEIGHT)

 MEAN 0.006 0.006 0.005** 0.005* 0.005

 S.D. 0.0006 0.0006 0.0008 0.0010 0.0008

 S.E. 0.0002 0.0002 0.0002 0.0003 0.0002

 N 12 12 12 10 12

 PITUITARY (G/100 G BRAIN)

 MEAN 1.044 0.971 0.811** 0.873* 0.891*

 S.D. 0.1420 0.0904 0.1476 0.1684 0.1088

 S.E. 0.0410 0.0261 0.0426 0.0533 0.0314

 N 12 12 12 10 12

 SPLEEN (G)

 MEAN 0.70 0.72 0.83 0.87 0.74

 % DIFFERENCE 2.9 18.6 24.3 5.7

 S.D. 0.099 0.153 0.218 0.151 0.223

 S.E. 0.028 0.044 0.063 0.048 0.064

 N 12 12 12 10 12

 SPLEEN (G/100 G FINAL BODY WEIGHT)

 MEAN 0.204 0.217 0.252* 0.259* 0.227

 S.D. 0.0214 0.0345 0.0549 0.0462 0.0619

 S.E. 0.0062 0.0100 0.0158 0.0146 0.0179

 N 12 12 12 10 12

-----------------------------------------------------------------------------------------------------------------------------------

* = Significantly different from the control group at 0.05 using Dunnett's test

** = Significantly different from the control group at 0.01 using Dunnett's test

Page 141 of 1107
 TABLE S45 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 SPLEEN (G/100 G BRAIN)

 MEAN 35.238 36.526 43.048 43.611 37.527

 S.D. 4.5542 7.0224 11.5808 7.2738 10.6020

 S.E. 1.3147 2.0272 3.3431 2.3002 3.0605

 N 12 12 12 10 12

-----------------------------------------------------------------------------------------------------------------------------------

None significantly different from control group

 POFBSTv5.26

 01/20/2014

Page 142 of 1107
 TABLE S46 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF MICROSCOPIC FINDINGS

 ----- MALE -----

-----------------------------------------------------------------------------------------------------------------------------------

 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NUMBER OF ANIMALS EXAMINED 12 1 0 12 12

COAGULATING GL

 TOTAL NUMBER EXAMINED 12 NA NA 12 12

 EXAMINED, UNREMARKABLE 12 NA NA 12 12

EPIDIDYMIS, LT

 TOTAL NUMBER EXAMINED 12 NA NA 12 12

 EXAMINED, UNREMARKABLE 12 NA NA 12 12

EPIDIDYMIS, RT

 TOTAL NUMBER EXAMINED 12 NA NA 12 12

 EXAMINED, UNREMARKABLE 12 NA NA 12 12

KIDNEYS

 TOTAL NUMBER EXAMINED 1 1 NA 1 2

 EXAMINED, UNREMARKABLE 0 0 NA 0 0

-CONGESTION 1 0 NA 0 0

-DEGENERATION, TUBULAR 0 0 NA 0 1

-DILATATION, PELVIS 1 1 NA 0 1

-INDENTATION, CAPSULAR 0 0 NA 1 0

LN, MANDIBULAR

 TOTAL NUMBER EXAMINED NA NA NA NA 1

 EXAMINED, UNREMARKABLE NA NA NA NA 0

-HYPERPLASIA, LYMPHOID NA NA NA NA 1

-----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROL GROUP USING 2-TAILED FISHER'S EXACT TEST.

NA = NOT APPLICABLE

Page 143 of 1107
 TABLE S46 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF MICROSCOPIC FINDINGS

 ----- MALE -----

-----------------------------------------------------------------------------------------------------------------------------------

 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NUMBER OF ANIMALS EXAMINED 12 1 NA 12 12

LUNGS

 TOTAL NUMBER EXAMINED 12 NA NA 12 12

 EXAMINED, UNREMARKABLE 4 NA NA 7 5

-ATELECTASIS 3 NA NA 2 3

-CONGESTION 0 NA NA 0 1

-HEMORRHAGE 0 NA NA 0 1

-INFLAMMATION, SUBACUTE 0 NA NA 1 0

-MINERALIZATION, VASCULAR 5 NA NA 2 4

PITUITARY

 TOTAL NUMBER EXAMINED 12 NA NA 12 12

 EXAMINED, UNREMARKABLE 12 NA NA 12 12

PROSTATE

 TOTAL NUMBER EXAMINED 12 NA NA 12 12

 EXAMINED, UNREMARKABLE 12 NA NA 10 11

-INFLAMMATION, SUBACUTE 0 NA NA 2 1

SEMINAL VESICLES

 TOTAL NUMBER EXAMINED 12 NA NA 12 12

 EXAMINED, UNREMARKABLE 12 NA NA 12 12

-----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROL GROUP USING 2-TAILED FISHER'S EXACT TEST.

NA = NOT APPLICABLE

Page 144 of 1107
 TABLE S46 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF MICROSCOPIC FINDINGS

 ----- MALE -----

-----------------------------------------------------------------------------------------------------------------------------------

 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NUMBER OF ANIMALS EXAMINED 12 1 NA 12 12

SPLEEN

 TOTAL NUMBER EXAMINED 12 NA NA 12 12

 EXAMINED, UNREMARKABLE 12 NA NA 11 12

-FIBROSIS, CAPSULAR 0 NA NA 1 0

-INFLAMMATION, CHRONIC 0 NA NA 1 0

TESTIS, RT

 TOTAL NUMBER EXAMINED 12 NA NA 12 12

 EXAMINED, UNREMARKABLE 12 NA NA 12 12

URETERS

 TOTAL NUMBER EXAMINED 1 1 NA NA NA

 EXAMINED, UNREMARKABLE 0 0 NA NA NA

 NOT PRESENT FOR EXAMINATION 0 0 NA NA 1

-DILATATION 1 1 NA NA NA

VAS DEFERENS

 TOTAL NUMBER EXAMINED 12 NA NA 12 12

 EXAMINED, UNREMARKABLE 12 NA NA 12 12

-----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROL GROUP USING 2-TAILED FISHER'S EXACT TEST.

NA = NOT APPLICABLE

 PHSI2v4.37

 02/18/2014

Page 145 of 1107
 TABLE S47 (F0 FEMALES - FAILED TO DELIVER)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF MICROSCOPIC FINDINGS

 ----- FEMALE -----

-----------------------------------------------------------------------------------------------------------------------------------

 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NUMBER OF ANIMALS EXAMINED 0 0 0 1 0

CERVIX

 TOTAL NUMBER EXAMINED 0 NA NA 1 0

 EXAMINED, UNREMARKABLE 0 NA NA 1 0

LUNGS

 TOTAL NUMBER EXAMINED 0 NA NA 1 0

 EXAMINED, UNREMARKABLE 0 NA NA 1 0

MAMMARY GLAND

 TOTAL NUMBER EXAMINED 0 NA NA 1 0

 EXAMINED, UNREMARKABLE 0 NA NA 1 0

OVARIES

 TOTAL NUMBER EXAMINED 0 NA NA 1 0

 EXAMINED, UNREMARKABLE 0 NA NA 1 0

PITUITARY

 TOTAL NUMBER EXAMINED 0 NA NA 1 0

 EXAMINED, UNREMARKABLE 0 NA NA 1 0

SPLEEN

 TOTAL NUMBER EXAMINED 0 NA NA 1 0

 EXAMINED, UNREMARKABLE 0 NA NA 1 0

-----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

NA = NOT APPLICABLE

Page 146 of 1107
 TABLE S47 (F0 FEMALES - FAILED TO DELIVER)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF MICROSCOPIC FINDINGS

 ----- FEMALE -----

-----------------------------------------------------------------------------------------------------------------------------------

 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NUMBER OF ANIMALS EXAMINED 0 NA NA 1 0

UTERUS

 TOTAL NUMBER EXAMINED 0 NA NA 0 0

 EXAMINED, UNREMARKABLE 0 NA NA 0 0

 NOT PRESENT FOR EXAMINATION 0 NA NA 1 0

VAGINA

 TOTAL NUMBER EXAMINED 0 NA NA 1 0

 EXAMINED, UNREMARKABLE 0 NA NA 1 0

-----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

NA = NOT APPLICABLE

 PHSI2v4.37

 02/18/2014

Page 147 of 1107
 TABLE S48 (F0 FEMALES - TOTAL LITTER LOSS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF MICROSCOPIC FINDINGS

 ----- FEMALE -----

-----------------------------------------------------------------------------------------------------------------------------------

 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NUMBER OF ANIMALS EXAMINED 0 0 0 1 0

CERVIX

 TOTAL NUMBER EXAMINED 0 NA NA 1 0

 EXAMINED, UNREMARKABLE 0 NA NA 1 0

LUNGS

 TOTAL NUMBER EXAMINED 0 NA NA 1 0

 EXAMINED, UNREMARKABLE 0 NA NA 1 0

MAMMARY GLAND

 TOTAL NUMBER EXAMINED 0 NA NA 1 0

 EXAMINED, UNREMARKABLE 0 NA NA 1 0

OVARIES

 TOTAL NUMBER EXAMINED 0 NA NA 1 0

 EXAMINED, UNREMARKABLE 0 NA NA 1 0

PITUITARY

 TOTAL NUMBER EXAMINED 0 NA NA 1 0

 EXAMINED, UNREMARKABLE 0 NA NA 0 0

-CYST, PARS DISTALIS 0 NA NA 1 0

SPLEEN

 TOTAL NUMBER EXAMINED 0 NA NA 1 0

 EXAMINED, UNREMARKABLE 0 NA NA 1 0

-----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

NA = NOT APPLICABLE

Page 148 of 1107
 TABLE S48 (F0 FEMALES - TOTAL LITTER LOSS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF MICROSCOPIC FINDINGS

 ----- FEMALE -----

-----------------------------------------------------------------------------------------------------------------------------------

 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NUMBER OF ANIMALS EXAMINED 0 NA NA 1 0

SPLEEN - CONTINUED

UTERUS

 TOTAL NUMBER EXAMINED 0 NA NA 1 0

 EXAMINED, UNREMARKABLE 0 NA NA 0 0

-EXUDATE, INFLAMMATORY 0 NA NA 1 0

-IMPLANTATION SITE 0 NA NA 1 0

VAGINA

 TOTAL NUMBER EXAMINED 0 NA NA 1 0

 EXAMINED, UNREMARKABLE 0 NA NA 1 0

-----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

NA = NOT APPLICABLE

 PHSI2v4.37

 02/18/2014

Page 149 of 1107
 TABLE S49 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF MICROSCOPIC FINDINGS

 ----- FEMALE -----

-----------------------------------------------------------------------------------------------------------------------------------

 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NUMBER OF ANIMALS EXAMINED 12 1 1 10 12

CERVIX

 TOTAL NUMBER EXAMINED 12 NA NA 10 12

 EXAMINED, UNREMARKABLE 12 NA NA 10 12

KIDNEYS

 TOTAL NUMBER EXAMINED NA 1 NA NA NA

 EXAMINED, UNREMARKABLE NA 1 NA NA NA

LUNGS

 TOTAL NUMBER EXAMINED 12 NA NA 10 12

 EXAMINED, UNREMARKABLE 7 NA NA 10 7

-ATELECTASIS 2 NA NA 0 2

-MINERALIZATION, VASCULAR 3 NA NA 0 3

MAMMARY GLAND

 TOTAL NUMBER EXAMINED 12 NA NA 10 12

 EXAMINED, UNREMARKABLE 12 NA NA 10 11

-INFLAMMATION, SUPPURATIVE 0 NA NA 0 1

OVARIES

 TOTAL NUMBER EXAMINED 12 NA NA 10 12

 EXAMINED, UNREMARKABLE 11 NA NA 9 12

-CYST, FOLLICULAR 1 NA NA 0 0

-HEMORRHAGE 0 NA NA 1 0

-----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROL GROUP USING 2-TAILED FISHER'S EXACT TEST.

NA = NOT APPLICABLE

Page 150 of 1107
 TABLE S49 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF MICROSCOPIC FINDINGS

 ----- FEMALE -----

-----------------------------------------------------------------------------------------------------------------------------------

 GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NUMBER OF ANIMALS EXAMINED 12 1 1 10 12

PITUITARY

 TOTAL NUMBER EXAMINED 12 NA NA 10 12

 EXAMINED, UNREMARKABLE 12 NA NA 10 12

SPLEEN

 TOTAL NUMBER EXAMINED 12 NA 1 10 12

 EXAMINED, UNREMARKABLE 12 NA 0 9 11

-FIBROSIS, CAPSULAR 0 NA 1 1 0

-HEMATOPOIESIS, EXTRAMEDULLARY, INCREASED 0 NA 0 0 1

UTERUS

 TOTAL NUMBER EXAMINED 12 NA NA 10 12

 EXAMINED, UNREMARKABLE 0 NA NA 1 0

-IMPLANTATION SITE 12 NA NA 9 12

VAGINA

 TOTAL NUMBER EXAMINED 12 NA NA 10 12

 EXAMINED, UNREMARKABLE 12 NA NA 10 12

-----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROL GROUP USING 2-TAILED FISHER'S EXACT TEST.

NA = NOT APPLICABLE

 PHSI2v4.37

 02/18/2014

Page 151 of 1107
 TABLE S50 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF OVARIAN PRIMORDIAL FOLLICLE COUNTS

 FEMALES

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 PRIMORDIAL FOLLICLES

 MEAN 49.3 NA NA 43.1 68.0

 S.D. 21.93 17.31 51.94

 S.E. 6.33 5.00 14.99

 N 12 12 12

-----------------------------------------------------------------------------------------------------------------------------------

None significantly different from control group

 MANUALv1.0

 01/21/2014

 R:01/21/2014

Page 152 of 1107
 TABLE S51 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF PND 0 LITTER DATA

 GROUP : 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NUMBER BORN

 MEAN 14.3 13.8 13.7 13.3 13.9

 S.D. 1.78 2.12 2.96 2.10 1.24

 S.E. 0.51 0.61 0.86 0.63 0.36

 N 12 12 12 11 12

SEX AT BIRTH (% MALES PER LITTER)

 MEAN 57.3 47.7 48.9 54.6 52.6

 S.D. 12.61 11.09 11.29 14.17 14.79

 S.E. 3.64 3.20 3.26 4.27 4.27

 N 12 12 12 11 12

LIVE LITTER SIZE (PND 0)

 MEAN 13.9 13.6 13.0 12.7 13.5

 S.D. 1.98 2.39 2.98 1.74 1.51

 S.E. 0.57 0.69 0.86 0.52 0.44

 N 12 12 12 11 12

-----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

SEX COMPARED USING DUNN'S TEST, NUMBER BORN, AND LIVE LITTER SIZE COMPARED USING DUNNETT'S

MODIFIED STATISTICS USED. * INDICATES PARAMETRIC ANALYSIS AND + INDICATES NON-PARAMETRIC ANALYSIS.

None significantly different from control group

 PPVIASv5.12

 02/18/2014

 R:02/18/2014

Page 153 of 1107
 TABLE S52 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF POSTNATAL SURVIVAL [% PER LITTER]

 GROUP : 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

PND 0 (RELATIVE TO NUMBER BORN)

 MEAN 96.5 98.0 95.2 95.4 97.0

 S.D. 4.76 5.11 5.80 6.79 5.75

 S.E. 1.37 1.48 1.67 2.05 1.66

 N 12 12 12 11 12

PND 0 TO PND 1

 MEAN 99.2 98.1 96.1 91.7 99.4

 S.D. 2.89 3.44 6.10 6.70 2.22

 S.E. 0.83 0.99 1.76 2.02 0.64

 N 12 12 12 11 12

PND 1 TO PND 4

 MEAN 97.1 95.9 91.7 76.5 99.3

 S.D. 4.92 7.52 12.64 31.21 2.41

 S.E. 1.42 2.17 3.65 9.41 0.69

 N 12 12 12 11 12

BIRTH TO PND 4

 MEAN 92.8 92.1 84.1 67.9 95.7

 S.D. 6.18 8.38 15.11 29.19 6.65

 S.E. 1.78 2.42 4.36 8.80 1.92

 N 12 12 12 11 12

-----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

STATISTICS PERFORMED USING DUNN'S TEST

MODIFIED STATISTICS USED.

None significantly different from control group

 PPVIASv5.12

 02/18/2014

 R:02/18/2014

Page 154 of 1107
 TABLE S53 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF PUPS

CATEGORY

 FINDING GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NORMAL

 NO SIGNIFICANT CLINICAL OBSERVATIONS 323/164 308/158 286/148 213/121 319/161

 LITTERS: 12 12 12 11 12

DISPOSITION

 FOUND DEAD; PARTIALLY CANNIBALIZED 0/ 0 0/ 0 0/ 0 0/ 0 2/ 2

 LITTERS: 0 0 0 0 2

 FOUND DEAD 11/ 11 11/ 11 16/ 16 33/ 33 5/ 5

 LITTERS: 8 6 9 10 4

 SCHEDULED EUTHANASIA 160/160 153/153 141/141 95/ 95 160/160

 LITTERS: 12 12 12 10 12

 MISSING 1/ 1 2/ 2 7/ 7 18/ 18 0/ 0

 LITTERS: 1 2 5 5 0

BODY/INTEGUMENT

 SMALL STATURE 1/ 1 6/ 3 3/ 2 2/ 2 1/ 1

 LITTERS: 1 3 2 2 1

 CYANOTIC 0/ 0 0/ 0 1/ 1 5/ 5 0/ 0

 LITTERS: 0 0 1 4 0

 SUBCUTANEOUS HEMORRHAGE DORSAL HEAD 0/ 0 0/ 0 0/ 0 2/ 2 0/ 0

 LITTERS: 0 0 0 2 0

 SUBCUTANEOUS HEMORRHAGE FACIAL AREA 0/ 0 0/ 0 2/ 1 5/ 5 1/ 1

 LITTERS: 0 0 1 4 1

-----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

Page 155 of 1107
 TABLE S53 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF PUPS

CATEGORY

 FINDING GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

 BODY PALE 2/ 2 0/ 0 1/ 1 0/ 0 0/ 0

 LITTERS: 2 0 1 0 0

 BODY COOL 1/ 1 1/ 1 0/ 0 0/ 0 0/ 0

 LITTERS: 1 1 0 0 0

 FILAMENTOUS TAIL 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0

 LITTERS: 0 0 0 1 0

 TAIL MISSING 0/ 0 0/ 0 0/ 0 4/ 2 0/ 0

 LITTERS: 0 0 0 2 0

CARDIO-PULMONARY

 GASPING 1/ 1 1/ 1 0/ 0 1/ 1 0/ 0

 LITTERS: 1 1 0 1 0

-----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

 PPOCRDv1.05

 01/07/2014

 R:01/17/2014

Page 156 of 1107
 TABLE S54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF OFFSPRING WEIGHTS [G]

 (LITTER AS EXPERIMENTAL UNIT)

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

PND 1

 MALES

 MEAN 6.8 7.9** 7.6** 7.3 7.8**

 % DIFFERENCE 16.2 11.8 7.4 14.7

 S.D. 0.87 0.60 0.33 0.58 0.59

 S.E. 0.25 0.17 0.10 0.18 0.17

 N 12 12 12 11 12

 FEMALES

 MEAN 6.6 7.3 7.2 6.9 7.2

 % DIFFERENCE 10.6 9.1 4.5 9.1

 S.D. 0.77 0.74 0.40 0.73 0.60

 S.E. 0.22 0.22 0.11 0.22 0.17

 N 12 12 12 11 12

PND 4

 MALES

 MEAN 9.6 10.2 9.7 9.7 10.2

 % DIFFERENCE 6.3 1.0 1.0 6.3

 S.D. 1.60 0.87 0.88 1.17 0.88

 S.E. 0.46 0.25 0.25 0.37 0.26

 N 12 12 12 10 12

 FEMALES

 MEAN 9.1 9.5 9.4 9.3 9.5

 % DIFFERENCE 4.4 3.3 2.2 4.4

 S.D. 1.48 0.88 0.75 1.29 0.62

 S.E. 0.43 0.25 0.22 0.41 0.18

 N 12 12 12 10 12

-----------------------------------------------------------------------------------------------------------------------------------

PND = POSTNATAL DAY

** = Significantly different from the control group at 0.01 using Dunnett's test

 PPWSUSNv5.17

 01/07/2014

 R:01/17/2014

Page 157 of 1107
 TABLE S55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF OFFSPRING WEIGHT CHANGES [G]

 (LITTER AS EXPERIMENTAL UNIT)

 GROUP: 0 PPM 50 PPM 100 PPM 175 PPM 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

PND 1 TO 4

 MALES

 MEAN 2.7 2.3 2.0 2.3 2.5

 S.D. 0.88 0.53 0.68 0.85 0.56

 S.E. 0.25 0.15 0.20 0.27 0.16

 N 12 12 12 10 12

 FEMALES

 MEAN 2.5 2.2 2.1 2.3 2.3

 S.D. 0.80 0.49 0.58 0.62 0.39

 S.E. 0.23 0.14 0.17 0.20 0.11

 N 12 12 12 10 12

-----------------------------------------------------------------------------------------------------------------------------------

PND = POSTNATAL DAY

None significantly different from control group

 PPWSUSNv5.17

 01/07/2014

 R:01/17/2014

Page 158 of 1107
 TABLE S56 (F1 - UNSCHEDULED DEATHS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. SUMMARY OF PUP NECROPSY FINDINGS

 FOUND DEAD OR EUTHANIZED MORIBUND OR IN EXTREMIS

-----------------------------------------------------------------------------------------------------------------------------------

 P U P S L I T T E R S

 DOSE GROUP: 1 2 3 4 5 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

NUMBER EXAMINED VISCERALLY 11 11 16 33 7 8 6 9 10 4

STOMACH

 MILK NOT PRESENT 3 3 8 10 3 3 2 6 6 3

 MILK PRESENT 1 0 0 2 0 1 0 0 2 0

MALFORMATION

 INTERVENTRICULAR SEPTAL DEFECT 0 0 1 5 0 0 0 1 2 0

 VERTEBRAL AGENESIS 0 0 0 1 0 0 0 0 1 0

 ANAL ATRESIA 0 0 0 1 0 0 0 0 1 0

 KIDNEY(S)- FUSED 0 0 0 1 0 0 0 0 1 0

 CONJOINED TWIN 1 0 0 0 0 1 0 0 0 0

VARIATION

 MAJOR BLOOD VESSEL VARIATION 0 0 0 1 0 0 0 0 1 0

 THORACIC CAVITY- CONTENTS, DARK RED 0 0 0 1 0 0 0 0 1 0

-----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 PPNSIv4.06

 02/24/2014

Page 159 of 1107
WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

APPENDIX A

Study Protocol and Deviations

 Page 160 of 1107
WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

DEVIATIONS FROM THE PROTOCOL

This study was conducted in accordance with the protocol and protocol amendments, 

except for the following.

• Protocol Section 5.7 states that individual cage cards will be affixed to each cage 

and will display the animal number, group number, study number, dosage level, and 

sex of the animal. On 25 November 2013, animals were sent to necropsy with 

pretest cage cards affixed to the animals’ cages. These labels did not include the 

group number or dosage level.

Impact Assessment: The slight deviation did not impact the study, as the animals 

were still identifiable by necropsy staff and were necropsied per protocol. 

• Protocol Section 7.4.3 states that the test and control items will be administered as a 

daily 6-hour whole-body inhalation exposure for Groups 1, 2, 3, and 4. The test item 

will be administered as a daily 5-minute exposure for Group 5. On 09 November 

2013, no end of exposure time was recorded for Chamber 5 (filtered air).

Impact Assessment: The lack of documentation of the end of exposure occurred in 

the filtered air chamber, and therefore had no impact on the quality or integrity of the 

study.

• Protocol Section 7.4.3 states that the test and control items will be administered as a 

daily 6-hour whole-body inhalation exposure for Groups 1, 2, 3, and 4. On 

10 November 2013, the exposure for Groups 2, 3, and 4 was extended. It was not 

documented that Chamber 1 (filtered air) was extended nor what time Chamber 1 

was opened. Since generation was terminated at 1608 hours and the first animal 

from Chamber 1 was not unloaded until 1613 hours, it is believed that Chamber 1 

was opened at 1608 hours, and therefore received an exposure of 6 hours 30 minutes.

Impact Assessment: The lack of documentation of the extended exposure occurred 

in the filtered air chamber, and therefore had no impact on the quality or integrity of 

the study.

 Page 161 of 1107
WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

• Protocol Section 7.4.4 states that the daily average relative humidity for each 

exposure chamber will be between 30% to 70%. On 18, 23, and 24 October 2013, 

the mean relative humidity for Chamber 5 (filtered air) was 28%, 29%, and 23%, 

respectively. On 02 November, 2013, the mean relative humidity for Chamber 5 

(10,000 ppm) was 76%. On 23 November 2013, the mean relative humidity for 

Chamber 4 (175 ppm) was 29.1%.

Impact Assessment: The slight deviation in humidity on these days had no impact 

on the study as there were no apparent effects on the animals based on post-exposure 

observations. 

• Protocol Section 7.4.4 states that the chambers will be operated under dynamic 

conditions, at a slight negative pressure (ca. 0.5 in. of water) with at least 12 to 15 air 

changes per hour. On 20 and 22 October 2013, Chamber 5 (10,000 ppm) was 

operated with more than 15 air changes per hour. On 26 October, 07 November, and 

08 November 2013, Chamber 5 (10,000 ppm) was operated with less than 12 air 

changes per hour. 

Impact Assessment: These deviations had no impact because animals were only in 

the 10,000 ppm exposure chamber for approximately 9 minutes and the variation in 

air changes per hour had no apparent effect on the animals based on post-exposure 

observations.

• Protocol Section 7.4.4 states that the chambers will be operated under dynamic 

conditions, at a slight negative pressure (ca. 0.5 in. of water) with at least 12 to 15 air 

changes per hour. On 07, 08, 24, 25, 26, and 27 October 2013 and 12 November 

2013, Chamber 5 (filtered air) was operated with less than 12 air changes per hour. 

Impact Assessment: These deviations had no impact on the study as the chamber 

was filtered air only.

• Protocol Section 7.4.4 states that the chambers will be operated under dynamic 

conditions, at a slight negative pressure (ca. 0.5 in. of water) with at least 12 to 15 air 

changes per hour. On 24 October 2013, Chamber 1 (filtered air) and Chamber 2

(50 ppm) were not operated at a slight negative pressure during the second round of 

sampling. On 27 October 2013, Chamber 1 (filtered air) and Chamber 3 (100 ppm)

were not operated at a slight negative pressure during fifth and first round of 

sampling, respectively. On 05 November 2013, Chamber 1 (filtered air) was not 

operated at a slight negative pressure during the sixth sampling round. On 

20 November 2013, Chamber 3 (100 ppm) and Chamber 4 (175 ppm) were not 

operated at a slight negative pressure during the first and second sampling rounds.

Impact Assessment: This deviation had no impact on the study as the chamber air 

was sampled throughout exposure and no test substance was detected.

 Page 162 of 1107
WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

• Protocol Section 7.6 does not state that homogeneity of exposure atmospheres will 

be performed. However, homogeneity was performed on Chamber 2 (50 ppm), 

Chamber 3 (100 ppm), Chamber 4 (175 ppm), and Chamber 5 (10,000 ppm).

Impact Assessment: The addition of homogeneity analysis ensures appropriate 

exposure to the test substance regardless of chamber location, and therefore did not 

impact the study.

• Protocol Section 7.6.2 states that actual concentrations of the test substance in the 

exposure atmospheres will be determined at least at hourly intervals for each 

chamber. On 14-21 October, 23-26 October, 29-30 October, 01 November, 

10 November, and 12 November 2013, the Chamber 5 (filtered air) concentrations 

were not determined at hourly intervals. 

Impact Assessment: The filtered air concentrations that were taken on these days 

were 0 ppm; therefore, this deviation had no impact on the quality or integrity of the 

study.

• Protocol Section 7.6.2 states that actual concentrations of the test substance in the 

exposure atmospheres will be determined at least at hourly intervals for each 

chamber. On 17 October 2013, Chamber 3 (100 ppm) and Chamber 4 (175 ppm) 

concentrations were not determined at hourly intervals. On 04 and 07 November 

2013, concentrations for Chamber 1 (filtered air), Chamber 2 (50 ppm), Chamber 3 

(100 ppm), and Chamber 4 (175 ppm) were not determined at hourly intervals. On 

28 November 2013, the concentration for Chamber 4 (175 ppm) was not determined 

at hourly intervals. 

Impact Assessment: This deviation had no impact on the study because sufficient 

sampling was performed to determine average concentrations for these days and the 

daily means were within 10% of the target concentration.

• Protocol Section 7.6.2 states that all chamber concentration data will be collected 

automatically through the use of the Inhalation Exposure Data Collection System 

(WINH) and a personal computer. Chamber 5 (filtered air and 10,000 ppm) 

concentration data was manually collected throughout the course of the study.

Impact Assessment: This deviation had no impact on the study because the 

chamber concentrations were collected.

 Page 163 of 1107
WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

• Protocol Section 7.6.3 states that the control and high-concentration chambers will 

be monitored for aerosol formation during method development. However, only the 

control (filtered air) and Chamber 4 (175 ppm) were monitored for aerosol formation 

during method development.

Impact Assessment: Chamber 4 (175 ppm) was the highest exposure concentration 

for the full 6-hour daily test substance exposure; therefore, aerosol formation was 

monitored as appropriate for this study design and this deviation had no impact on 

the quality and integrity of the study.

• Protocol Section 7.7 states that daily vaginal lavages will be performed to determine 

the stage of estrus beginning 10 days prior to treatment and continuing until evidence 

of mating is observed. The cytology slide for female no. 91672 in the control group 

was unable to be analyzed at the time of the determination of stage of estrous 

because the slide was inadvertently discarded. The slide was broken when it was 

discarded and, therefore, determination of estrous stage was not possible.

Impact Assessment: The loss of a single data point of estrous cycle data for a 

control animal had no impact on the study, as there was sufficient cycle data for this 

female.

• Protocol Section 7.7 states that daily vaginal lavages will be performed to determine 

the stage of estrus beginning 10 days prior to treatment and continuing until evidence 

of mating is observed. Lavaging will continue for those females with no evidence of 

mating until termination of the mating period. Upon review of raw data, it was noted 

that female no. 91623 in the 175 ppm group had a slide present for determination of 

stage of estrous 1 day after the scheduled completion date of determination of stage 

of estrous. 

Impact Assessment: This deviation has no impact on the study, as the female was 

determined to be nongravid as appropriate.

• Protocol Section 7.11.1 states that each animal will be observed approximately

1 hour following each exposure for findings that are potentially related to treatment 

or that might change before the next scheduled observation. Based on the 

unscheduled observations noted on the first day of exposure for Group 5 

(10,000 ppm), post-exposure observations were also conducted at approximately

15 minutes and approximately 1 hour following the 5-minute test substance exposure

period for Group 5 (10,000 ppm) for the remainder of the exposure period. 

Impact Assessment: The addition of observation time points to allow for capture of 

adverse clinical observations for Group 5 (10,000 ppm) had no impact on the quality

or integrity of the study.

 Page 164 of 1107
WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

• Protocol Section 7.11.1 states that all animals will be observed on the day of 

necropsy and findings will be recorded. However, 6 males and 4 females in the 

control group, 6 males and 3 females in the 50 ppm group, 6 males and 3 females in 

the 100 ppm group, 6 males and 1 female in the 175 ppm group, and 6 males and 

5 females in the 10,000 ppm group did not receive a clinical observation prior to 

being sent to necropsy. 

Impact Assessment: The lack of single observation for each animal did not affect 

data interpretation for this study.

• Protocol Section 7.11.1 states that a detailed physical examination would be 

conducted weekly. Female no. 91637 in the control group received a detailed 

physical examination on the 18 and 19 November 2013. 

Impact Assessment: Additional observations for a single animal had no impact on 

the quality or integrity of the study.

• Protocol Section 8.3 states that sections of 2-4 microns of the testis (transverse) will 

be stained in PAS and hematoxylin in addition to routine hematoxylin and eosin 

staining. At the time of trimming, it was discovered that 5 males from the 

10,000 ppm group (nos. 91600, 91557, 91554, 91571, 91575, and 91558) had 

incorrectly trimmed testes. Testes for each animal were trimmed longitudinally

instead of transverse. The wet tissue remnants for each animal were pieced together 

so that a transverse section could be submitted for each animal. 

Impact Assessment: This deviation had no impact on the study as the longitudinal 

sections were corrected and a transverse view was examined.

 Page 165 of 1107
PROTOCOL AMENDMENT 2

Study Number: WIL-65501

Sponsor: American Pacific Corporation

Title of Study:

An Inhalation Reproduction/Developmental Toxicity Screening Study of 

2-Bromo-3,3,3-Triflouropropene in Rats

Protocol Modifications:

1) 8.3 Microscopic Examination:

The first sentence of this section is changed to the following:

Microscopic examination will be performed on the following tissues from all F0

parental animals from the control and 175 ppm and 10,000 ppm dose groups and from 

all parental animals dying spontaneously or euthanized in extremis. All gross lesions 

will be examined microscopically, irrespective of group.

Reasons for Protocol Modification:

1) Addition of 175 ppm exposure level for histopathological examination. The 175 ppm 

group was the high dose for the full 6 hour exposure duration.

 Page 166 of 1107
Page 2 of' 2 

Sponsor's approval was obtained via cmail on 02 January 2014. 

WTL Research 

Study Director 

American Pacific Corpora tiot 

Sponsor Representative 

 Page 167 of 1107
PROTOCOL AMENDMENT 1

Study Number: WIL-65501

Sponsor: American Pacific Corporation

Title of Study:

An Inhalation Reproduction/Developmental Toxicity Screening Study of

2-Bromo-3,3,3-Triflouropropene in Rats

Protocol Modifications:

1) 2.4 Contributing Scientist, Study Pathologist:

The following personnel added:

Catherine A. Picut, VMD, DACVP, DABT

Senior Pathologist

WIL Research

310 Millstone Dr.

Hillsborough, NC 27278

Tel: (919) 245-3114 x106

Fax: (919) 245-3115

Email: catherine.picut@wilresearch.com

2) 7.11.2.2 Females:

The second paragraph is removed from this section as noted below:

Recorded individually on a weekly basis, beginning on the first day of exposure until 

evidence of copulation is observed or until euthanasia (for females without evidence of 

mating). Following evidence of copulation, body weights will be recorded on gestation 

days 0, 4, 7, 11, 14, 17 and 20 and lactation days 1 and 4. For females with evidence of 

mating that do not deliver, body weights will have been recorded on the presumed 

gestation days indicated above and then on the day of scheduled euthanasia (post-mating 

day 25). 

If a female is determined to have completed parturition at the morning parturition 

examinations, a lactation day 0 weight will be recorded for the female, and the weight 

 Page 168 of 1107
WIL-65501

Page 2 of 3 Protocol Amendment 1

will be used for calculation of dose volume. The lactation day 0 weights will not be 

summarized or analyzed statistically but will be included on the individual animal data 

tables.

3) 7.12.1.2 Female Which Fail to Deliver: 

The following is added to this section:

If the females are determined to be pregnant by macroscopic examination or 

ammonium sulfide staining, the number of implantation sites and corpora lutea will 

be recorded. Any products of conception will be discarded without further 

examination.

4) 8.1 Macroscopic Examination:

The mammary glands will be collected from the females only. For the liver, sections 

of 2 lobes will be retained.

5) 10.1 Parental In-life Data:

The first sentence is changed to the following: 

Continuous data variables [mean body weights, body weight gains, food consumption 

and water consumption at each interval], pre-coital intervals, mean estrous cycle 

length, gestation length, former implantation sites, corpora lutea and unaccounted-for 

sites will be subjected to a parametric one-way analysis of variance (ANOVA) 

(Snedecor and Cochran, 1980) to determine intergroup difference. 

Reasons for Protocol Modification:

1) Addition of Study Pathologist.

2) Removal of typographical error; not required as exposure is via inhalation.

3) Addition of examination of the uterus in the event of pregnancy for females which 

fail to deliver.

4) Clarification that mammary glands are to be collected from females only.

5) Addition of statistical analysis on the water consumption data being collected.

 Page 169 of 1107
Page 3 of 3 

WIL-65503 

Protocol Amendment I 

sponsor's approval was obtained via email an 21 October 2013. 

WL Research 

0cT 7Ct3 

mye L. Edwards, BS Date 

Study Director 

American Pacific Corpora tion A 

V ~radford Colton Date 

Sponsor Representative 

 Page 170 of 1107
WIL-65501

Page 1 of 29 25 September 2013

PROTOCOL

An Inhalation Reproduction/Developmental

Toxicity Screening Study of 2-Bromo-3,3,3-Trifluoropropene in Rats

[OECD Guideline 421]

WIL Study Number: WIL-65501

Submitted To:

American Pacific Corporation

3883 Howard Hughes Parkway, Suite 700

Las Vegas, NV 89169

WIL Research

1407 George Road

Ashland, OH 44805-8946

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Page 2 of 29 25 September 2013

1 OBJECTIVE:

To provide preliminary information on the potential adverse effects of the test item on 

male and female reproduction within the scope of a screening study. This will 

encompass gonadal function, mating behavior, conception, parturition and lactation of 

the F0 generation and the development of offspring from conception through day 4 of 

postnatal life.

This study will be conducted in accordance with the Organisation for Economic 

Cooperation and Development (OECD) Guideline for Testing of Chemicals, 

Guideline 421, Reproduction/Development Toxicity Screening Test, July 27, 1995. 

This study will be conducted in compliance with the EPA/TSCA (40 CFR Part 792) 

Good Laboratory Practice Standards and the OECD [C(97) 186/Final] Principles of 

Good Laboratory Practice.

2 PERSONNEL INVOLVED IN THE STUDY:

2.1 Sponsor Representative:

Bradford Colton

American Pacific Corporation

3883 Howard Hughes Parkway, Suite 700

Las Vegas, NV USA 89169

Tel: (702) 699-4131

Fax: (702) 735-4876

Email: bcolton@apfc.com

2.2 Sponsor Monitor:

Stephanie Skaggs

Universal Technical Services, Inc.

Tel: (505) 856-1847

Cell: 505) 681-5585 

Fax: (505) 212-0491

Email:srskaggs@msn.com

2.3 WIL Study Director:

Tammye L. Edwards, BS

Senior Toxicologist, Developmental 

and Reproductive Toxicology

Tel: (419) 289-8700

Fax: (419) 289-3650

Email: tammye.edwards@wilresearch.com

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2.4 Contributing Scientist, Study Pathologist:

To be added by amendment

2.5 Contributing Scientist, Ovarian Primordial Follicle Evaluation:

Catherine A. Picut, VMD, DACVP, DABT

Senior Pathologist

WIL Research

310 Millstone Dr.

Hillsborough, NC 27278

Tel: (919) 245-3114 x106

Fax: (919) 245-3115

Email: catherine.picut@wilresearch.com

2.6 Principal Investigator (Ovarian Histology):

Sirena Hudgins, HT (ASCP)

Supervisor, Histology

WIL Research

310 Millstone Dr.

Hillsborough, NC 27278

Tel: (919) 245-3114 x114

Fax: (919) 245-3115

Email: sirena.hudgins@wilresearch.com

2.7 Test Site Quality Assurance:

For histology conducted at WIL Research at Hillsborough:

Janice Jackson-Freeman

Compliance Specialist, Quality Assurance

WIL Research 

310 Millstone Dr.

Hillsborough, NC 27278

Tel: (919) 245-3114 x119

Fax: (919) 245-3115

Email: janice.freeman@wilresearch.com

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2.8 WIL Departmental Responsibilities:

Prägati Sawhney-Coder, PhD, DABT

Senior Toxicologist, Developmental and

Reproductive Toxicology

Emergency Contact

Tel: (419) 289-8700

Fax: (419) 289-3650

Email: Pragati.Sawhney.Coder@wilresearch.com

Donald G. Stump, PhD, DABT

Vice President, Nonclinical Safety Science, US

Eddie D. Sloter, PhD

Associate Director, Developmental 

and Reproductive Toxicology

Erica L. Lashley, BS, LAT

Senior Operations Manager, Animal Operations

Gwendalyn M. Maginnis, DVM

Clinical Veterinarian 

Carol A. Kopp, BS, LAT

Manager, Developmental Toxicology Laboratory

Andrew M. Vick, PhD

Senior Director, Analytical Services

George A. Parker, DVM, PhD, DACVP, DABT

Vice President, Global Pathology

Heather L. Johnson, BS RQAP-GLP

Assistant Director, Quality and Regulatory Compliance

Robert A. Wally, BS

Operations Manager, Reporting & 

Technical Support Services

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3 STUDY SCHEDULE:

Proposed Experimental Starting 

(Animal Receipt) Date: 26 September 2013 

Proposed Experimental Start 

(First Day of Exposure) Date: 14 October 2013 

Proposed Completion of In-life Phase

Date: 06 December 2013

Proposed Experimental Completion/ 

Termination (Last Pathological 

Examination) Date: To be added by Amendment 

Proposed Unaudited Draft Report: 29 January 2014 

Proposed Audited Report Date: 28 February 2014 

4 TEST ITEM DATA:

4.1 Test Item Shipment:

Test item and applicable documentation, including a Certificate of Analysis, 

will be shipped under Sponsor’s responsibility to: 

Tammye Edwards (WIL-65501) 

Attn: Formulations Laboratory

WIL Research

1407 George Road 

Ashland, Ohio 44805-8946 

Tel: (419) 289-8700 

Fax: (419) 289-3650 

Email: tammye.edwards@wilresearch.com

4.2 Identification:

2-Bromo-3,3,3-Trifluoropropene, CAS:1514-82-5 

This material contains stabilizer additives:

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4.3 Lot Number:

WNCC-BTP111128

4.4 Expiration/Retest Date:

10/1/2014

4.5 Purity:

≥99.6% 

4.6 Storage Conditions:

Store room temperature or cooler. Store in closed container which is free of air 

and moisture.

4.7 Stability:

The test item is considered to be stable under the storage conditions provided by 

the Sponsor. This material is susceptible to degradation when exposed to air 

and moisture. All connections, hoses, and headspace of cylinders material is 

transferred into should be under vacuum or purged with nitrogen or argon.

4.8 Reserve Samples:

Reserve samples of the test item will be taken in accordance with WIL Standard 

Operating Procedures and stored in the WIL Research Archives indefinitely, 

unless otherwise specified.

4.9 Personnel Safety Data:

To be provided by the Sponsor. It is the responsibility of the Sponsor to notify 

the testing facility of any special handling requirements for the test item. 

A Material Safety Data Sheet (MSDS) should accompany the test item upon 

arrival at the laboratory.

4.10 Test Item Disposition:

With the exception of the reserve sample for each batch of test item, all neat test 

item remaining at study completion will be returned to the Sponsor. The test 

item will be shipped under ambient conditions to the following:

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Page 7 of 29 25 September 2013

Clay Heyborne

Halotron Division

American Pacific Corporation

10622 West 6400 North 

Cedar City, Utah 84721-9016

Tel: (435) 865-5000

Email: cheyborne@apfc.com

5 TEST SYSTEM:

5.1 Species:

Rat

5.2 Strain:

Sprague Dawley Crl:CD(SD)

5.3 Source:

Charles River Laboratories, Inc.

(Facility to be documented in the study records).

5.4 Number on Study:

60 males and 60 females (minimum of 66 males and 66 females purchased; 

males and females will be ordered from separate barrier rooms to ensure 

avoidance of sibling mating). Animals not assigned to study will be transferred 

to the stock animal colony or will be euthanized by carbon dioxide inhalation 

and the carcasses discarded.

The number of animals is based on the OECD Guideline for Testing of 

Chemicals: Guideline 421, Reproduction/Development Toxicity Screening Test, 

July 27, 1995, which recommends evaluation of at least 8 pregnant females per 

group. Given the possibility of non-gravid animals, unexpected deaths, total 

litter losses, or treatment-related moribundity and/or mortality, this is an 

appropriate number of animals to obtain a sample size of 8 at termination.

5.5 Body Weight Range:

At randomization: Males 250-500 g

Females 170-280 g

5.6 Approximate Age:

Males: 71-85 days at the start of dosing

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Females: 61-75 days at the start of estrous cycle determination

All rats will be a minimum of 85 days of age at the start of the breeding period.

5.7 Identification System:

The F0 animals will be uniquely identified by a Monel® metal ear tag displaying 

the animal number. Individual cage cards will be affixed to each cage and will 

display the animal number, group number, study number, dosage level, and sex 

of the animal.

5.8 Justification for Selection:

This species and strain of animal is recognized as appropriate for reproduction 

studies. WIL Research has reproductive historical control data in the 

Crl:CD(SD) rat. This animal model has been proven to be susceptible to the 

effects of reproductive toxicants.

6 SPECIFIC MAINTENANCE SCHEDULE:

6.1 Animal Housing:

All males will be individually housed in clean suspended wire-mesh cages in an 

environmentally controlled room during acclimation and continuing until 

euthanasia. All females will be individually housed in clean suspended 

wire-mesh cages in an environmentally controlled room during acclimation and 

continuing until mating. The cages will be elevated above cage-board or other 

suitable material, which will be changed at least three times each week. During 

cohabitation, the females will be paired (1:1) with a male from the same 

treatment group in a suspended wire-mesh cage (home cage of the male). 

Following successful mating, the females will be housed individually in a 

plastic cage containing ground corncob nesting material (Bed-O'Cobs

®) and will 

remain in these cages until euthanasia on lactation day 4. Nylabone® (or a 

similar enrichment device) will be provided to each animal for environmental 

enrichment and to aid in maintaining the animal's oral health, beginning during 

acclimation and continuing throughout the course of the study. The cages will 

be subjected to routine cleaning at a frequency consistent with maintaining good 

animal health and WIL Standard Operating Procedures. The facilities at WIL 

Research are accredited by the Association for Assessment and Accreditation of 

Laboratory Animal Care International (AAALAC International).

6.2 Environmental Conditions:

Controls will be set to maintain temperature at 71 ± 5°F (22 ± 3°C) and relative 

humidity at 50 ± 20%. Temperature and relative humidity will be monitored 

continuously. Data for these two parameters will be scheduled for automatic 

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collection on an hourly basis. Fluorescent lighting controlled by light timers 

will provide illumination for a 12-hour light/dark photoperiod. The ventilation 

rate will be set at a minimum of 10 room air changes per hour, 100% fresh air.

6.3 Drinking Water:

Reverse osmosis-purified water will be available ad libitum except during test 

item exposure from water bottles attached the cages. Water consumption will be 

recorded during the study; therefore, the cages will not be attached the 

automatic watering system. The municipal water supplying the laboratory is 

analyzed according to WIL Standard Operating Procedures on a routine basis to 

ensure that contaminants are not present in concentrations that would be 

expected to affect the outcome of the study.

Water restriction during the exposure period is necessary to avoid any 

contamination with the test item during the inhalation exposure. This restriction

has been performed in this type of study historically at WIL Research and there 

have been no adverse consequences of the daily temporary water restriction 

during exposure. In addition, the health of the animal will be monitored 

through collection of daily body weights and food consumption throughout the 

exposure period.

6.4 Basal Diet:

PMI Nutrition International, LLC Certified Rodent LabDiet® 5002 will be 

offered ad libitum during the study except during test item exposure. Periodic 

analyses of the certified feed are performed by the manufacturer to ensure that 

heavy metals and pesticides are not present at concentrations that would be 

expected to affect the outcome of the study. Results of the analyses are 

provided to WIL Research by the manufacturer. Feeders will be changed and 

sanitized once per week. 

Diet restriction during the exposure period is necessary to avoid contamination 

of the diet with the test material during the inhalation exposure. This restriction 

has been performed in this type of study historically at WIL Research and there 

have been no adverse consequences of the daily temporary food restriction 

during exposure. In addition, the health of the animal will be monitored 

through collection of daily body weights and food consumption through the 

exposure period.

7 EXPERIMENTAL DESIGN:

7.1 Animal Receipt and Quarantine:

Each animal will be inspected by a qualified technician upon receipt. Rats 

judged to be in good health and suitable as test animals will be immediately 

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placed in quarantine for a minimum of 7 days. All rats will be initially 

weighed, permanently identified with a metal ear tag and receive a clinical 

observation. During the quarantine period, each rat will be observed twice daily 

for changes in general appearance and behavior. For all males, the testes will be 

palpated at least once during the quarantine period. Prior to the start of the inlife phase, those animals judged to be suitable test subjects will be identified 

and receive a detailed physical examination.

7.2 Randomization:

At the conclusion of the quarantine period, animals judged to be suitable test 

subjects and meeting acceptable body weight requirements, will be assigned at 

random using a computer program. At that time, the animal numbers and 

corresponding body weights will be entered into the WIL Toxicology Data 

Management System (WTDMS). A printout containing the animal numbers 

and individual group assignments will be generated based on body weight 

stratification into a block design. Animals will then be arranged into the groups 

according to the printout. The control group and four test item groups will 

consist of 12 males and 12 females each. 

Any animal assigned to the study that is found dead, euthanized in extremis or 

exhibits abnormal clinical signs, reduced food consumption or body weight 

losses prior to the start of dosing may be replaced by an animal of appropriate 

age when possible. Replacement animals will be arbitrarily assigned (not 

computer randomized) to the study based on comparable body weights (if 

possible) with respect to the animal that was replaced.

7.3 Route and Rationale of Test Item Administration:

The route of administration will be whole body inhalation exposure because the 

intended use of the test item indicated that this would be a likely route of human 

exposure.

7.4 Organization of Test Groups, Dosage Levels and Treatment Regimen:

7.4.1 Rationale for Dose Selection:

The dosage levels will be determined from results of a previous 

reproductive toxicity screening study (Brooker, 2013). Rats were 

exposed to the test item for 6-hours daily, 7 days a week from 15 days 

pre-mating through Lactation Day 10 at levels of 200, 500 and 3000 

ppm. A no-observed-adverse-effect level could not be established based 

on dose-related clinical observations of underactivity, unresponsiveness, 

piloerection and partially closed eyelids and reduced body weight and 

food consumption. In addition, estrous cycles, pre-coital intervals and 

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gestation periods were increased in a dose-related manner and post-natal 

survival and litter sizes were decreased. Based on these observations, the 

highest dose level selected was 175 ppm for the 6-hour exposure and the 

lower dose levels were selected to assess the dose-response relationship. 

The dose level selected for the short 5-mintue exposure period is 

expected to mimic an actual exposure from a complete discharge of a 

fire extinguisher within the space of an aircraft, or confined space. 

Industry guidelines for halon alternatives either allow a 5-minute 

concentration at the cardiotox LOAEL or 5-minute maximum 

concentration based on PBPK modeling. The LOAEL of 2-bromo3,3,3-trifluoropropene is 1% volume (Horrell, 2002). The exposure 

level tested will be equivalent to the test item obtaining a 1% 

concentration in the atmosphere of the enclosed aircraft or similar space. 

The potential effects on reproduction and development have not been 

tested previously for this exposure level and time.

7.4.2 Organization of Test Groups:

The following table presents the study group arrangement.

Group/Number Test Item

Exposure Level 

(ppm)

Number of 

Animals

Males Females

1 Control Filtered Air 12 12

2 CAS:1514-82-5 50 12 12

3 CAS:1514-82-5 100 12 12

4 CAS:1514-82-5 175 12 12

5 CAS:1514-82-5 10,000 12 12

7.4.3 F0 Treatment Regimen:

The test and control items will be administered as a daily 6-hour wholebody inhalation exposure for Groups 1, 2, 3, and 4. The test item will be 

administered as a daily 5-minute whole-body exposure for Group 5. All 

animals will be exposed at approximately the same time each day as 

follows:

7.4.3.1 Males:

F0 males will be exposed for a minimum of 14 days prior to 

mating and continuing until the day prior to the scheduled 

euthanasia. The total exposure period for the F0 males will 

encompass at least 28 consecutive days.

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7.4.3.2 Females:

F0 females will be exposed for a minimum of 14 days prior to 

mating and continuing throughout mating until gestation day 20, 

inclusively. F0 females with no evidence of mating or that do not 

deliver will be exposed until one day prior to scheduled 

euthanasia on either post-cohabitation day 25 or post-mating day 

25, respectively.

7.4.4 Exposure Methods:

Control and test item exposures for Groups 1, 2, 3 and 4 will be 

conducted in 1.0-m3 stainless-steel and glass exposure chambers and 

Group 5 will be exposed in a 0.5-m3 stainless-steel and glass exposure 

chamber. Four chambers will be dedicated to each of the four test item

exposure groups, while the fifth chamber will be dedicated to the control 

group. The chambers will be operated under dynamic conditions, at a 

slight negative pressure (ca. 0.5 in. of water) with at least 12 to 15 air 

changes per hour. Oxygen content of the exposure atmosphere will be at 

least 19% and will be documented during the pre-study methods 

development phase. Temperature and relative humidity during exposures 

will be measured at least once every hour for each chamber and the daily 

average will be between 19oC and 25oC, and 30% to 70%, respectively.

All animals will be housed in normal animal colony rooms during 

non-exposure hours. For each day’s exposure, the animals will be 

transferred to exposure caging, transported to the exposure chamber 

room, exposed for the requisite duration and returned to their home 

cages. Animal cage batteries will be rotated through the various 

possible chamber locations on a daily basis.

7.5 Generation of Exposure Atmospheres:

Appropriate equipment and procedures for generation of test substance 

atmospheres at the required concentrations will be determined during the 

pre-study method development. If appropriate for the test substance and the 

selected exposure levels, vapors will be generated by bubbling nitrogen through 

minimally heated test substance in an appropriate flask. A suitable heating 

element (tape or mantle) will be used to provide a stable temperature, if heating 

is required. Additional vaporization approaches, such as a heated glass-bead 

column type vaporization system are available, and may be used, if required. 

Test substance and vaporization nitrogen are metered to the column, and 

nitrogen enters below the glass beads while test substance is deposited on the 

beads. Vaporization occurs as the test substance flows down over the beads and 

nitrogen moves up through the beads. The concentrated vapors will be piped to 

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the chamber inlet where the concentration will be reduced to the desired level 

by mixing with chamber ventilation air. The atmosphere for the control 

chamber will be generated using the same procedure except that no test 

substance will be added. The details of the selected and validated method will 

be included in the final report.

7.6 Characterization of Exposure Atmospheres:

7.6.1 Nominal Exposure Concentrations:

Nominal exposure concentrations will be calculated for each day’s 

exposure using the following formula:

ppm = Wt. • Mol. Vol. • 106

MW • Ch. Flow • Exp. Dur.

Where:

Wt. = the weight of test substance used during a 

given day’s exposure, grams

Mol. Vol. = Molar volume at 730 mm Hg and 21oC

106 = ppm conversion factor

MW = molecular weight

Ch. Flow = Daily average chamber flowrate for a given 

day, in L/min

Exp. Dur. = Duration of a given days’ exposure, in 

minutes

7.6.2 Actual Exposure Concentrations:

Actual concentrations of the test substance in the exposure atmospheres 

will be determined at least at hourly intervals for each chamber using an 

appropriate automated gas chromatography method.

All chamber concentration data will be collected automatically through 

the use of the Inhalation Exposure Data Collection System (WINH) and 

a personal computer. Measurements of test substance concentration will 

commence after the t99 start-up period. At each sampling, chamber 

temperature, relative humidity and airflow will be recorded. Daily 

results will show the mean analyzed concentration ± the standard 

deviation.

7.6.3 Aerosol Monitoring:

The control and high-concentration chambers will be monitored for 

aerosol formation during method development. A light-scattering 

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aerosol photometer (MIE, Inc., Billerica, MA, or equivalent) will be 

used for this evaluation.

7.7 Determination of Estrous Cycles:

Daily vaginal lavages will be performed to determine the stage of estrus 

beginning 10 days prior to treatment and continuing until evidence of mating is 

observed. Lavaging will continue for those females with no evidence of mating 

until termination of the mating period. Estrous cycle determination will be 

conducted on all females, including stock, during the pretest period in the event 

animal replacement is necessary.

7.8 F0 Breeding:

After a minimum of 14 days of exposure, one female will be cohabitated with 

one male rat of the same treatment group, avoiding sibling mating 

(Charles River Laboratories will supply non litter mates), in a suspended wire 

mesh cage for mating. Detection of mating will be confirmed by the appearance 

of a vaginal copulatory plug or by evidence of sperm in a vaginal lavage. 

Vaginal lavages will be performed daily during the mating period until evidence 

of mating is observed. After confirmation of mating, the female will be 

returned to an individual plastic maternity cage and the day will be designated 

as day 0 of gestation.

A maximum of 14 days will be allowed for mating. After 14 days of mating, 

any females who have not shown evidence of breeding will be placed in a 

plastic maternity cage containing nesting material.

7.9 F0 Parturition and Lactation and F1 Litters:

The day parturition is initiated will be designated as day 0 of lactation. Any 

difficulties at the time of parturition will be recorded. When parturition is 

judged to be complete, the sex of each pup will be determined, pups will be 

examined for gross malformations and the number of stillbirths and live pups 

will be recorded. Any changes or abnormalities in nesting and nursing behavior 

will be recorded. The dam and litter will remain together until postnatal 

day (PND) 4.

7.10 Identification of F1 Litters:

Upon completion of delivery, all pups will be individually identified by tattoo 

markings applied to the digits. Standardization for litter size will not be 

performed.

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7.11 General Observations During the Experimental Period:

7.11.1 Parental Appearance and Behavior:

Each parental rat (F0) will be observed twice daily for moribundity and 

mortality, once in the morning and once in the afternoon. A detailed 

physical examination will be conducted weekly. Mortality and all signs 

of overt toxicity will be recorded on the day observed. The 

Observations shall include, but are not limited to, evaluations for 

changes in appearance of the skin and fur, eyes and mucous membranes, 

respiratory, circulatory, autonomic and central nervous systems, 

somatomotor activity and behavior. During the period of expected 

parturition, the dams will be observed twice daily for dystocia, 

prolonged labor, delayed labor or other difficulties at parturition. All 

animals will also be observed on the day of necropsy and findings will 

be recorded.

During the exposure period, each animal will be observed approximately 

1 hour following each exposure for findings that are potentially related 

to treatment or that might change before the next scheduled observation. 

Additional post-exposure observations may be necessary and will be 

documented in the study records. 

7.11.2 Parental Body Weights:

All animals will have a final body weight recorded on the day of 

euthanasia.

7.11.2.1 Males:

Recorded individually on a weekly basis, beginning on the first 

day of exposure, until euthanasia. 

7.11.2.2 Females:

Recorded individually on a weekly basis, beginning on the first 

day of exposure until evidence of copulation is observed or until 

euthanasia (for females without evidence of mating). Following 

evidence of copulation, body weights will be recorded on 

gestation days 0, 4, 7, 11, 14, 17 and 20 and lactation days 1 and 

4. For females with evidence of mating that do not deliver, body 

weights will have been recorded on the presumed gestation days 

indicated above and then on the day of scheduled euthanasia 

(post-mating day 25). 

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If a female is determined to have completed parturition at the 

morning parturition examinations, a lactation day 0 weight will 

be recorded for the female, and the weight will be used for 

calculation of dose volume. The lactation day 0 weights will not 

be summarized or analyzed statistically but will be included on 

the individual animal data tables.

7.11.3 Parental Food Consumption:

Individual food consumption will not be recorded during the breeding 

period because the animals are cohabitated at that time.

7.11.3.1 Males:

Recorded individually on a weekly basis, beginning on the first 

day of exposure, until euthanasia.

7.11.3.2 Females:

Recorded individually on a weekly basis beginning on the first 

day of exposure, until the start of the mating period. Individual 

food consumption will be recorded on the day evidence of 

copulation is observed (GD 0) and on gestation days 4, 7, 11, 14, 

17 and 20 and lactation days 1 and 4. 

For females with no evidence of mating, individual food 

consumption will continue to be recorded on a weekly basis 

following the end of the mating period until euthanasia. For 

females that do not deliver, individual food consumption will 

have been recorded on the presumed gestation days and on the 

day of scheduled euthanasia (post-mating day 25).

7.11.4 Parental Water Consumption:

Individual water consumption will not be recorded during the breeding 

period because the animals are cohabitated at that time.

7.11.4.1 Males:

Recorded individually on a daily basis beginning on the first day 

of exposure, until euthanasia for all males. Water consumption 

will be reported on a weekly basis.

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7.11.4.2 Females:

Recorded individually on a daily basis beginning on the first day 

of exposure, until euthanasia for all females. For females with 

evidence of mating and delivery, water consumption will be 

reported on a weekly basis during the pre-mating period and on 

gestation days 4, 7, 11, 14, 17 and 20 and lactation days 1 and 4. 

For females with no evidence of mating, water consumption will 

be reported on a weekly basis and females that do not deliver will 

have water consumption recorded throughout presumed gestation 

as indicated above and on the day of scheduled euthanasia (postmating day 25). 

7.11.5 Examination of Offspring:

7.11.5.1 Appearance and Behavior:

All pups will be observed daily for general appearance and 

behavior and survival during lactation. A detailed physical 

examination will be recorded for each pup on PND 1 and 4. 

Any abnormalities in nesting and nursing behavior will be 

recorded and pups will be sexed on PND 0 and 4.

7.11.5.2 Body Weights:

Each pup will be weighed on PND day 1 and 4.

7.11.5.3 Pup Deaths:

Moribund pups will be euthanized by an intraperitoneal 

injection of sodium pentobarbital. Stillborn pups, pups found 

dead, and any pups that are euthanized in extremis will be 

dissected (including the heart and the brain examined by a 

mid-coronal slice) by a technique described by Stuckhardt and 

Poppe (1984). If a skeletal anomaly is suspected, the pup will 

be eviscerated, cleared and stained with Alizarin Red S as 

described by Dawson (1926) and examined. Any findings will 

be recorded as either developmental variations or 

malformations. Representative specimens with malformations 

may be preserved in 10% neutral buffered formalin at the 

discretion of the Study Director.

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7.12 Euthanasia of F0 Generation:

7.12.1 Females:

7.12.1.1 Females Which Deliver:

On lactation day 4, all F0 females that delivered will be 

euthanized by carbon dioxide inhalation. The abdominal, pelvic 

and thoracic cavities will be opened and the contents examined. 

The number of former implantation sites and corpora lutea will 

be recorded. Organ weights will be collected and tissues 

preserved as described in Section 8.

7.12.1.2 Females Which Fail to Deliver:

On post-mating day 25 (females with evidence of copulation) or 

post-cohabitation day 25 (females without evidence of 

copulation), the F0 females which fail to deliver will be 

euthanized by carbon dioxide inhalation. The abdominal, pelvic 

and thoracic cavities will be opened and the contents examined. 

Uteri which appear nongravid by macroscopic examination will 

be opened and placed in a 10% ammonium sulfide solution 

(Salewski, 1964) for detection of early implantation loss. 

Organ weights will be collected and tissues preserved as 

described in Section 8 with the exception of any ammonium 

sulfide stained uterus, which will be discarded. 

7.12.1.3 Females with Total Litter Loss:

Females with total litter loss will be euthanized by carbon 

dioxide inhalation on the same day. The number of former 

implantation sites and corpora lutea will be recorded. Organ 

weights will be collected and tissues preserved as described in 

Section 8.

7.12.1.4 F0 Deaths and Animals Euthanized in Extremis:

Females not surviving until the scheduled euthanasia will be 

necropsied as described in Section 8. Animals not expected to 

survive to the next observation period (moribund) will be 

euthanized by carbon dioxide inhalation and necropsied as 

described in Section 8, with the following exceptions: Organ 

weights will not be collected and the number and location of 

implantation sites or scars and corpora lutea will be recorded for 

females dying or euthanized during gestation and lactation. 

Tissues will be preserved as described in Section 8. Viable 

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fetuses will be euthanized by a subcutaneous injection of sodium 

pentobarbital in the scapular region. Recognizable fetuses will 

be examined externally for gross abnormalities. Representative 

specimens with malformations may be preserved in 10% neutralbuffered formalin, at the discretion of the study director. For 

females found dead or euthanized in extremis during lactation, all 

pups will be examined externally, euthanized by an 

intraperitoneal injection of sodium pentobarbital and necropsied 

according to Section 7.11.5.3. 

7.12.2 Males:

Following completion of the mating period (minimum of 28 daily 

doses), all F0 males will be euthanized by carbon dioxide inhalation, 

assessed for spermatogenesis, and subjected to a gross necropsy and 

tissues preserved as described in Section 8. 

Males not surviving until the scheduled euthanasia will be necropsied as 

described in Section 8. Any males not expected to survive to the next 

observation period (moribund) will be euthanized by carbon dioxide 

inhalation and also necropsied as described in Section 8. Organ weights 

will not be collected and spermatogenesis will not be performed on 

found dead or euthanized early animals.

7.13 Euthanasia of F1 Generation:

On PND 4, the F1 pups will be euthanized via an intraperitoneal injection of 

sodium pentobarbital and discarded.

7.14 Spermatogenesis Evaluations:

The following quantitative assessment of the process of spermatogenesis will be 

performed on all males at study termination.

If the left testis or epididymis is noted with a gross lesion, these organs will not 

be homogenized. Instead, the right testis and epididymis will be used for 

enumeration of cauda epididymal and testicular sperm and sperm production 

rate and the left testis and epididymis will be used for motility/viability and

morphology assessments as well as for preservation in modified Davidson’s 

solution for subsequent microscopic examination.

7.14.1 Motility/Viability Assessment:

Immediately after euthanasia, the reproductive tract of the male will be 

exposed via a ventral mid-line incision. The right epididymis will be 

excised and weighed separately. An incision will be made in the distal 

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region of the right cauda epididymis, and the cauda will be placed in a 

beaker containing Dulbecco's phosphate-buffered saline (maintained at

approximately 37oC) with 10 mg/mL Bovine Serum Albumin (BSA). 

A small sample of the diluted sperm will be loaded into a 100-μm 

chamber for determination of motility. Because sperm motility can be 

affected by temperature shock, all slides and diluents will be warmed 

prior to use in an incubator, and motility determinations will be 

performed under constant temperature (approximately 37oC) using the 

Hamilton-Thorne HTM-IVOS Version 14 (or higher) computer-assisted 

sperm analysis (CASA) system. Analysis of at least 200 motile and 

nonmotile spermatozoa (if possible) per animal in all exposure groups 

will be performed by the analyzer. The percent motile and percent 

progressively motile will be reported. The right epididymis will then be 

preserved in accordance with Section 8.1.

7.14.2 Morphology Assessment:

Sperm morphology will be evaluated by a modification of the 

wet-mount evaluation technique (Linder et al, 1992). Abnormal forms 

of sperm (double heads, double tails, microcephalic or megacephalic, 

etc.) from a differential count of 200 spermatozoa (if possible) per 

animal in all groups will be recorded.

7.14.3 Enumeration of Epididymal and Testicular Sperm and Sperm 

Production Rate (SPR):

The left testis and cauda epididymis will be weighed, homogenized and 

evaluated for sperm numbers and the sperm production rate will be 

calculated (Blazak et al, 1985) utilizing the Hamilton-Thorne CASA 

system. The homogenized sample will be mixed with a DNA-specific 

fluorescent dye to allow identification of the sperm under fluorescent

illumination. The right testis and epididymis, and the remainder of the 

left epididymis, will be preserved in modified Davidson’s fixative for 

subsequent microscopic examination as described in Section 8.3. 

8 ANATOMIC PATHOLOGY:

8.1 Macroscopic Examination:

A complete necropsy will be conducted on all F0 parental animals dying 

spontaneously, euthanized in extremis (by carbon dioxide inhalation) or at 

termination. This will include examination of the external surface, all orifices, 

the cranial cavity, the external surface of the brain and the thoracic, abdominal 

and pelvic cavities including viscera. For F0 females, the number of former 

implantation sites and corpora lutea will be recorded.

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At the time of necropsy, the following tissues and organs will be collected and 

placed in 10% neutral-buffered formalin (except as noted):

Brain

Coagulating gland

Kidneys

Liver

Lungs

Mammary glands 

Ovariesa and oviduct (2)

Pituitary gland

Prostate gland

Seminal vesicles (2)

Spleen

Testes with epididymides (2)b,c

 and vas deferens

Uterusd with cervix and vagina

All gross lesionse

a - Ovaries will be fixed in 10% neutral-buffered formalin for approximately 48 hours 

following which all ovaries will be transferred to 70% Ethanol.

b- Testis (right) and epididymis (right and remainder of left) will be fixed in modified 

Davidson’s solution. Both testes and epididymides from males found dead or 

euthanized in extremis will be fixed in modified Davidson’s solution. Care will be 

taken to ensure separation between the left and right organs. 

 c - If the left testis or epididymis is noted with a gross lesion, the left testis and 

epididymis will be fixed in modified Davidson’s solution and the right testis and 

epididymis will be homogenized according to section 7.18.3. 

d - Any uterus stained in 10% ammonium solution for detection of implantation sites 

will be discarded and not preserved in 10% neutral buffered formalin.

e - Representative sections of corresponding organs from a sufficient number of 

controls will be retained for comparison, if possible.

8.2 Organ Weights:

The following organs will be weighed from all F0 parental animals euthanized at 

scheduled termination. Organ-to-final-body weight and organ-to-brain weight 

ratios will be evaluated.

Brain

Epididymides*

(total and caudal)

Kidneys

Liver

Lungs

Ovaries (without oviducts)

Pituitary gland

Spleen

Testes*

* - These paired organs will be weighed separately. Care will be taken to ensure 

separation between the left and right organs.

8.3 Microscopic Examination:

Microscopic examination will be performed on the following tissues from all F0

parental animals from the control and high-dose groups and from all parental 

animals dying spontaneously or euthanized in extremis. All gross lesions will 

be examined microscopically, irrespective of group.

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Tissues and organs fixed in 10% neutral-buffered formalin, or other fixatives (as 

noted in Section 8.1) from animals scheduled for microscopic examination (as 

noted above) will be embedded in paraffin, sectioned and stained with 

hematoxylin and eosin (H&E) for microscopic evaluation. Sections of the testes 

and epididymides will also be stained with Periodic Acid-Schiff’s stain (PAS) 

and hematoxylin. Tissues and organs from all other animals will be maintained 

in the appropriate fixatives in the event that additional histopathology is 

requested by the Sponsor.

Cervix

Coagulating gland

Epididymidesa,b

Lungs

Mammary glands (female only)

Ovariesc,d

Pituitary gland

Prostate gland

Seminal vesicles

Spleen

Testesa,b

Uterus

Vagina

Vas deferens

All gross (internal) lesions

a - Sections of 2-4 microns of the testis (transverse) and epididymis (longitudinal) will 

be stained in PAS and hematoxylin in addition to routine hematoxylin and eosin 

staining. 

b- If the left testis or epididymis is noted with a gross lesion, the left testis and 

epididymis will be fixed in modified Davidson’s solution and the right testis and 

epididymis will be homogenized according to section 7.14.3.

c- All ovaries will be paraffin embedded. Five (5) sections will be taken approximately 

100 μm apart from the inner third of each ovary from all the F0 females in the control 

and high dose groups at scheduled termination and for any females suspected of 

reduced fertility. In addition, a single section will be taken for a qualitative bilateral 

evaluation of each ovary. A quantitative histopathologic evaluation of multiple 

sections will be conducted. This examination will include enumeration of the total 

number of primordial follicles according to the methods of Bolon et al (1997), Bucci

et al (1997) and Picut et al (2008). 

d – For females found dead, or euthanized in extremis, a single section from each ovary 

will be qualitatively evaluated.

Microscopic examination may be extended to other organs/tissues, groups if a 

potential target organ is noted based on histopathological examination of tissues 

from the high-dose group or other parameters after approval of the Sponsor and 

at additional cost).

Ovarian tissues will be shipped to the attention of the Principal Investigator 

(Ovarian Histology) at the address provided in Section 2. This is a WILdesignated test site. Histology slide preparation will be conducted following the 

Standard Operating Procedures of WIL Research at Hillsborough, and in 

accordance with the Protocol and applicable GLPs. The Principal Investigator 

(Ovarian Histology), will be responsible for all delegated-phase activities. Any 

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deviations from the GLPs or Protocol and any study specific SOP deviations 

will be reported to the Study Director.

9 DURATION OF STUDY:

The two generations to be studied (parental animals and first generation offspring) 

will be termed F0 and F1, respectively. The conduct of this study will require 

approximately 10 weeks for acclimation, mating, gestation and lactation of the 

F0 generation.

10 STATISTICAL METHODS:

All analyses will be two-tailed for significance levels of 5% and 1%. All means will 

be presented with standard deviations. All statistical tests will be performed by a 

computer with appropriate programming as referenced below. Following completion 

of the mating period, data from nongravid females will be excluded from calculation 

of means and from comparative statistics. The litter, rather than the pup, will be 

considered as the experimental unit.

10.1 Parental In-Life Data:

Continuous data variables [mean body weights, body weight gains and food 

consumption at each interval], pre-coital intervals, mean estrous cycle length,

gestation length, former implantation sites, corpora lutea and unaccounted-for 

sites will be subjected to a parametric one-way analysis of variance (ANOVA) 

(Snedecor and Cochran, 1980) to determine intergroup difference. If the results 

of the ANOVA are significant (p<0.05), Dunnett's test (Dunnett, 1964) will be 

applied to the data to compare the treated groups to the control group.

Male and female mating, fertility, copulation and conception indices of the 

treated groups will be compared to the control group using the Chi-square test 

with Yates' correction factor (Hollander and Wolfe, 1999).

10.2 Litter Data:

The mean litter proportions (% per litter) of pup viability during the postnatal 

period and sex ratio at birth will be subjected to the Kruskal-Wallis 

nonparametric ANOVA test (Kruskal and Wallis, 1952) to determine intergroup 

difference. If the results of the ANOVA are significant (p<0.05), the 

Dunn’s Test (Dunn, 1964) will be applied to the data to compare the treated 

groups to the control group. Mean litter weights, live litter size, mean pup body 

weights and mean pup body weight gains and number of pups born will be 

subjected to the parametric ANOVA test (Snedecor and Cochran, 1980) and 

Dunnett's test (1964) as described above with the litter representing the 

experimental unit.

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10.3 Histopathology and Organ Weight Data:

Histopathological findings of each treated group will be compared to those of 

the control group by the Fisher’s Exact test (Steel and Torrie, 1980). Organ 

weights (absolute and relative to body weights and relative to brain weights)

and mean number of ovarian primordial follicles will be subjected to a 

parametric ANOVA test (Snedecor and Cochran, 1980) and Dunnett's test 

(1964) as described above.

10.4 Spermatogenic Endpoint Evaluations:

The percentage of motile spermatozoa and percentage of sperm with normal 

morphology will be subjected to the Kruskal-Wallis nonparametric ANOVA 

test (1952) followed the Dunn’s Test (1964) as described above. Epididymal 

and testicular sperm numbers and sperm production rates will be subjected to a 

parametric ANOVA test (Snedecor and Cochran, 1980) and Dunnett's test 

(1964) as described above.

11 QUALITY ASSURANCE:

The study will be audited by the WIL Research Quality Assurance Department while 

in progress to assure compliance with Good Laboratory Practice Regulations, 

adherence to the protocol and to WIL Standard Operating Procedures. The protocol, 

protocol amendments, raw data, draft report and final report will be audited by the 

WIL Research Quality Assurance Department prior to submission to the Sponsor to 

assure that the final report accurately describes the conduct and the findings of the 

study. This study will be conducted in compliance with the EPA/TSCA 

(40 CFR Part 792) Good Laboratory Practice Standards and the OECD [C(97) 

186/Final] Principles of Good Laboratory Practice.

Histology slide preparation for ovarian primordial follicle evaluation will be 

conducted following the Standard Operating Procedures of WIL Research at 

Hillsborough, and in accordance with the Protocol and GLPs. Quality Assurance 

monitoring of these analyses for Protocol, SOP and GLP compliance is the 

responsibility of WIL Research at Hillsborough. Inspection reports will be supplied to 

the Study Director. Upon completion of the prescribed activities, WIL Research at 

Hillsborough will provide a signed Quality Assurance Statement to the Study Director 

which will be included in the final report.

This study will be included on the WIL Research master list of regulated studies.

12 RECORDS TO BE MAINTAINED:

All original raw data records, as defined by WIL Research SOPs and the applicable 

GLPs, will be stored as described in Section 13 in the WIL Research Archives.

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13 WORK PRODUCT:

The Sponsor will have title to all documentation records, raw data, specimens and 

other work product generated during the performance of the study. Any remaining 

samples (e.g. formulation or blood/plasma/serum) will be discarded after issuance of 

the Final Report. All work product generated at WIL Research at Hillsborough will be 

returned to WIL Research. All work product, including raw paper data, pertinent 

electronic storage media and specimens, will be retained at no charge for six months 

following issuance of the final report in the WIL Research Archives. Thereafter, 

WIL Research will charge a monthly archiving fee for retention of all work product. 

All work product will be stored in compliance with regulatory requirements.

Any work product, including documents, specimens, and samples, that are required 

by this protocol, its amendments, or other written instructions of the Sponsor, to be 

shipped by WIL Research to another location will be appropriately packaged and 

labeled as defined by WIL’s SOPs and delivered to a common carrier for shipment. 

WIL Research will not be responsible for shipment following delivery to the common 

carrier.

All work product generated at a performing laboratory will be retained at an 

appropriate archive facility as designated by the SOPs of the performing laboratory.

14 REPORTS:

The final report will contain a summary, test item information, methods and 

procedures, appropriate individual animal and summary data tables, WIL Research 

Historical Control Data, supporting sub-reports, a copy of the protocol and 

amendment(s), if any, and an interpretation and discussion of the study results. The 

final report will be comprehensive and shall define level(s) inducing toxic effects as 

well as no-effect level(s) under the conditions of this investigation. The report will 

contain all information necessary to conform to current OECD specifications.

WIL Research will submit an electronic copy (PDF and MS Word copy of the report 

text for editing and comments) of the audited draft report in a timely manner upon 

completion of data collection prior to issuance of the final report. It is expected that 

the Sponsor will review the draft report and provide comments to WIL Research

within a two-month time frame following submission. WIL Research shall provide a 

revised draft report that incorporates the Sponsor's reasonable revisions and

suggestions. One revision will be permitted as part of the cost of the study; additional 

changes or revisions may be made, at extra cost. WIL Research shall submit the final 

report within two weeks of receiving authorization to finalize the report from the 

Sponsor. If the Sponsor’s comments and/or authorization to finalize the report have 

not been received at WIL Research within one year following submission of the draft 

report, WIL Research may elect to finalize the report following appropriate written 

notification to the Sponsor. An electronic copy (bookmarked and hyperlinked PDF) 

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of the final report will be provided; requests for paper copies of the final report may 

result in additional charges.

15 ANIMAL WELFARE ACT COMPLIANCE:

This study will comply with all applicable sections of the Final Rules of the Animal 

Welfare Act (AWA) regulations (9 CFR). The protocol will be reviewed by the WIL 

Institutional Animal Care and Use Committee (IACUC) prior to commencement of 

study specific activities. The Sponsor should make particular note of the following:

• The Sponsor Representative's signature on this protocol documents for the Study 

Director the Sponsor's assurance that the study described in this protocol does not 

unnecessarily duplicate previous experiments.

• Whenever possible, procedures used in this study have been designed to avoid or 

minimize discomfort, distress or pain to animals. All methods are described in this 

study protocol or in written laboratory Standard Operating Procedures.

• Animals that experience severe or chronic pain or distress that cannot be relieved 

will be painlessly euthanized as deemed appropriate by the veterinary staff and 

Study Director. The Sponsor will be advised by the Study Director of all 

circumstances which could lead to this action in as timely a manner as possible.

• Methods of euthanasia used during this study are in conformance with the 

above-referenced regulation.

• The Sponsor/Study Director has considered alternatives to procedures that may 

cause more than momentary or slight pain or distress to the animals and has 

provided a written narrative description (AWA covered species) of the methods and 

sources used to determine that alternatives are not available.

16 PROTOCOL MODIFICATION:

Modification of the protocol may be accomplished during the course of this 

investigation. However, no changes will be made in the study design without the 

verbal or written permission of the Sponsor. In the event that the Sponsor verbally 

requests or approves a change in the protocol, such changes will be made by 

appropriate documentation in the form of protocol amendment. All alterations of the 

protocol and reasons for the modification(s) will be signed by the Study Director and 

the Sponsor Representative.

17 REFERENCES:

Blazak, W.F.; Ernst, T.L.; Stewart, B.E. Potential indicators of reproductive toxicity: 

testicular sperm production and epididymal sperm number, transit time and motility in 

Fischer 344 rats. Fundamental and Applied Toxicology 1985, 5 (6 Pt. 1), 1097-1103.

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Bolon, B., Bucci, T.J., Warbritton, A.R., Chen, J.J., Mattison D.R. and Heindel, J.J. 

Differential follicle counts as a screen for chemically induced ovarian toxicity in mice: 

Results from continuous breeding bioassays. Fundam. Appl. Toxicol. 1997, 39, 1-10.

Brooker, A.J. 2-bromo-3,3,3-trifluoropropene: Reproductive/Developmental Toxicity 

Screening Study in the CD Rat by Inhalation Administration. Huntingdon Life Sciences 

Study: WAG0015. 2013.

Bucci, T.J., Bolon, B., Warbritton, A.R., Chen, J.J., and Heindel, J.J. Influence of 

Sampling on the reproducibility of ovarian follicle counts in mouse toxicity studies. 

Reprod. Toxicol. 1997, 11(5), 689-696.

Dawson, A.B. A note on the staining of the skeleton of cleared specimens with Alizarin 

Red S. Stain Technology 1926, 1, 123-124.

Dunn, O.J. Multiple comparisons using rank sums. Technometrics 1964, 6(3), 241-252.

Dunnett, C.W. New tables for multiple comparisons with a control. Biometrics 1964,

20, 482-491

Hollander, M.; Wolfe, D.A. Nonparametric Statistical Methods, 2nd ed.; Hollander, M., 

Wolfe, D.A., Eds.; John Wiley and Sons, Inc.: New York, NY, 1999; p 468.

Horrell, P.J. Agent 873: An Inhalation Study to Investigate the Cardiac Sensitisation 

Potential in the Beagle. Huntingdon Life Sciences, Ltd. Study: AAS 001/014630. 2002.

Kruskal, W.H.; Wallis, W.A. Use of ranks in one-criterion variance analysis. Journal 

of the American Statistical Association 1952, 47, 583-621.

Linder, R.E.; Strader, L.F.; Slott, V.L.; Suarez, J.D. Endpoints of spermatotoxicity in the 

rat after short duration exposures to fourteen reproductive toxicants. Reproductive 

Toxicology 1992, 6, 491-505.

Picut, C.A.; Swanson, C.L.; Scully, K.L.; Roseman, V.C.; Parker, R.F.; Remick, A.K. 

Ovarian Follicle Counts Using Proliferating Cell Nuclear Antigen (PCNA) and SemiAutomated Image Analysis in Rats. Toxicol Pathol. 2008 May 8. 

Salewski, E. Färbemethode zum makroskopischen Nachweis von Implantationsstellen 

am Uterus der Ratte. [Staining method for a macroscopic test for implantation sites in 

the uterus of the rat]. Naunyn - Schmiedebergs Archiv für Experimentelle Pathologie 

und Pharmakologie 1964, 247, 367.

Snedecor, G.W.; Cochran, W.G. One Way Classifications; Analysis of Variance. In 

Statistical Methods, 7th ed.; The Iowa State University Press: Ames, IA, 1980;

pp 215-237.

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Steel, R.G.D.; Torrie, J.H. Principles and Procedures of Statistics, A Biometrical 

Approach, 2nd ed.; McGraw-Hill Book Company: New York, NY, 1980; pp 504-506.

Stuckhardt, J.L.; Poppe, S.M. Fresh visceral examination of rat and rabbit fetuses used 

in teratogenicity testing. Teratogenesis, Carcinogenesis and Mutagenesis 1984, 4,

181-188.

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18 PROTOCOL APPROVAL: 

Sponsor approval received via email on 24 September 20 1 3. 

%radfoxd Colton 

Sponsor Representative 

WIL Resestrch 

~adnye L. Edwards, BS 

Study Dktor 

ad +t 

Date 

a/Sepat3 

Date 

 Page 199 of 1107
WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

APPENDIX B

Certificate of Analysis (Sponsor-Provided Data)

 Page 200 of 1107
AMPAC" 

HALOTRON 

Phone (435) 865 - 5000 

AMEFUCAN PACIFIC CORPORATION - UTAH OPERATIONS 

10622 W 6400 N 

CEDAR CITY, UTAH 84720 

Fax (435) 865 - 5029 

CERTIFICATE OF ANALYSIS 

MATERIAL: 

CUSTOMER: 

QUANTITY: 

LOT #: 

P.O. NUMBER: 

O.I.D. NUMBER: 

LINE ITEM NUMBER: 

SPECIFICATION: 

DATE OF MANUFACTURE; 

DATE: 

PROPERTY 

Assay 

Acidity (by weip,ht as HBr) 

Non Volatile Residue 

Appearance (Color) 

Appearance (Clarity) 

Stabilized 2-Bromo-3,3,3-trifluoropropene 

(2-BTP) 

WIL Research 

180 Ib 

WNCC-BTP111128 

NA 

NA 

NA 

AMP-QSP-072, Rev 01 

November 20 1 1 

22 October 2013 

CERTIFIED VALUE 

>99.4 

11 

<I 

1400 

Light Yellow, < 200 

< 15 

15 ppm Max 

3 pprn Max 

4000 ppm Max 

200 Color Units Max 

15 NTU Max 

The signing of this document by an authorized representative of the Quality Assurance department indicates that the material is in conformance with 

specified requirements. Information contained in this report applies only to the material related to the specified lot number. This report shall not be 

reproduced, except in full, without written approval from AMPAC. 

Where references to NELAC accreditation is made on any certificate or report, all requirements of the associated standard regarding information on the report will be met. 

Doc ID: 002910 

HI-LAB-090-FM-06 

Director Analvtical Laboratories 

Date Title 

Rev: 00 Effective Date: 06 November Pag 1 2007 of I 

CERTIFIED COPY 

 Page 201 of 1107
AMPAC" 

HALOTRON 

Phone (435) 865 - 5000 

AMERICAN PACIFIC CORPORATION - UTAH OPERATIONS 

10622 W 6400 N 

CEDAR CITY, UTAH 84720 

Fax (435) 865 - 5029 

CERTIFICATE OF ANALYSIS 

CUSTOMER: 

QUANmr: 

LOT #: 

P.O. NUMBER: 

O.I.D. NUMBER: 

LINE ITEM NUMBER: 

SPECIFICATION: 

DATE OF MANUFACTLTRE: 

DATE: 

PROPERTY 

Assay 

Water-ppm 

Acidity (by weight as HBr) 

Non Volatile Residue 

Appearance (Color) 

Appearance (Clarity) 

Stabilized 2-Bromo-3,3,3-trifluoropropene 

(2-BTP) 

HuntingdonLife Sciences Ltd. 

2827 kg 

WNCC-BTP111128 

72032.2 

170588 

AMP-QSP-072, Rev 00 

November 20 1 1 

02 April 2012 

CERTIFIED VALUE 

960 

Light Yellow, < 200 

SPECITICATION 

99.0% Min 

15 ppm Max 

3 ppm Max 

4000 ppm Max 

200 Color Units Max 

15 NTU Max 

The signing of this document by an authorized representative of the Quality Assurance department indicates that the material is in conformance with 

specifid requ~~enp..Info,gation contgiqed in this repofl applies only to the mateal related to the specjfied lot nqmbq. This report shall not be 

reproduced, except in fill, without written approval from WAC. 

Where references to NELAC accreditation is made on any certificate or report, all requirements of the associated standard regarding information on 

the report will be met. 

Doc ID: 002910 

HI-LAB-090-FM-06 

Rev: 00 

Director Analytical Laboratories 

Title 

Effective Date: 06 November 2007 

Page 1 of I 

 Page 202 of 1107
WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

APPENDIX C

Exposure Atmosphere Generation Report (WIL Research)

 Page 203 of 1107
An Inhalation Reproduction/Developmental

Toxicity Screening Study of 2-Bromo-3,3,3-Trifluoropropene in Rats

Exposure Atmosphere Generation Report

Date Issued

14 March 2014

Date Amendment Issued

19 March 2014

WIL Research Inhalation Department

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

- Page 1 of 9 -

 Page 204 of 1107
WIL-65501 

American Pacific Corporation 

AMENDMENT TO THE FINAL INHALATION REPORT 

Inhalation Table 2, Inhalation Table 4, and Inhalation Table 6 

Original Report Pages: 27,28,31,32,35,36 

Amendment to Final Inhalation Report Pages: 4,5,6,7,8,9 

m: Replaced Inhalation Table 2, Inhalation Table 4, and Inhalation Table 6. 

Reason for Chanze: Updated Inhalation Table 2, Inhalation Table 4, and Inhalation Table 6 

were not included in the final inhalation report 

The amendment did not entail generation of new data, revision of calculations, or modification of 

previously submitted data. The revisions to the inhalation final report included in the 

amendment may have resulted in changes in pagination in the inhalation final report; any 

potential changes in pagination are not addressed in this amendment. 

The signature below certifies that the revised pages have been reviewed and approved by the 

Lead Technician. 

d.p.: l!! *- l4MkRLolY 

Arthur J. Stephens, BA Date 

Biologist, Inhalation Toxicology 

Lead Technician 

- Page2of9 

 Page 205 of 1107
REVISED PAGES

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

- Page 3 of 9 -

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 INHALATION TABLE 2

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN CHAMBER TEMPERATURE [DEGREES CELSIUS]

-----------------------------------------------------------------------------------------------------------------------------------

 GROUP: 0 PPM 10000 PPM

 DATE CHAMBER: 5A 5B

-----------------------------------------------------------------------------------------------------------------------------------

 10/14/13 23 22

 10/15/13 23 22

 10/16/13 23 23

 10/17/13 25 25

 10/18/13 23 22

 10/19/13 23 22

 10/20/13 22 22

 10/21/13 23 23

 10/22/13 23 22

 10/23/13 23 23

 10/24/13 25 23

 10/25/13 24 23

 10/26/13 24 22

 10/27/13 24 23

 10/28/13 23 23

 10/29/13 23 23

 10/30/13 23 23

 10/31/13 23 24

 11/01/13 24 23

 11/02/13 24 22

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

- Page 4 of 9 -

Page 207 of 1107
 INHALATION TABLE 2

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN CHAMBER TEMPERATURE [DEGREES CELSIUS]

-----------------------------------------------------------------------------------------------------------------------------------

 GROUP: 0 PPM 10000 PPM

 DATE CHAMBER: 5A 5B

-----------------------------------------------------------------------------------------------------------------------------------

 11/03/13 24 23

 11/04/13 24 23

 11/05/13 24 23

 11/06/13 24 23

 11/07/13 24 23

 11/08/13 24 23

 11/09/13 25 23

 11/10/13 24 22

 11/11/13 24 22

 11/12/13 23 22

 11/13/13 23 21

 11/14/13 23 23

 11/15/13 23 23

 11/16/13 23 22

 11/17/13 22 22

 11/18/13 23 22

 11/19/13 22 22

 11/20/13 22 21

-----------------------------------------------------------------------------------------------------------------------------------

 GRAND MEAN 23 23

 SD 0.8 0.8

 CV(%) 3.48 3.48

 N 38 38

 MANUALv1.0

 12/15/2013

 R:02/07/2014

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- Page 5 of 9 -

Page 208 of 1107
 INHALATION TABLE 4

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN CHAMBER RELATIVE HUMIDITY [%]

-----------------------------------------------------------------------------------------------------------------------------------

 GROUP: 0 PPM 10000 PPM

 DATE CHAMBER: 5A 5B

-----------------------------------------------------------------------------------------------------------------------------------

 10/14/13 52 60

 10/15/13 53 61

 10/16/13 54 59

 10/17/13 37 50

 10/18/13 28 51

 10/19/13 30 61

 10/20/13 30 51

 10/21/13 31 60

 10/22/13 30 51

 10/23/13 29 61

 10/24/13 23 58

 10/25/13 56 56

 10/26/13 60 51

 10/27/13 58 61

 10/28/13 56 60

 10/29/13 58 62

 10/30/13 61 61

 10/31/13 55 63

 11/01/13 57 58

 11/02/13 60 76

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

- Page 6 of 9 -

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 INHALATION TABLE 4

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN CHAMBER RELATIVE HUMIDITY [%]

-----------------------------------------------------------------------------------------------------------------------------------

 GROUP: 0 PPM 10000 PPM

 DATE CHAMBER: 5A 5B

-----------------------------------------------------------------------------------------------------------------------------------

 11/03/13 58 60

 11/04/13 58 62

 11/05/13 57 59

 11/06/13 59 61

 11/07/13 58 60

 11/08/13 56 61

 11/09/13 54 59

 11/10/13 62 60

 11/11/13 57 59

 11/12/13 54 58

 11/13/13 52 53

 11/14/13 56 56

 11/15/13 55 51

 11/16/13 53 54

 11/17/13 60 61

 11/18/13 61 60

 11/19/13 59 51

 11/20/13 60 58

-----------------------------------------------------------------------------------------------------------------------------------

 GRAND MEAN 51 58

 SD 11.6 4.9

 CV(%) 22.75 8.45

 N 38 38

 MANUALv1.0

 12/16/2013

 R:02/07/2014

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 INHALATION TABLE 6

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN CHAMBER VENTILATION RATE [L/MIN]

-----------------------------------------------------------------------------------------------------------------------------------

 GROUP: 0 PPM 10000 PPM

 DATE CHAMBER: 5A 5B

-----------------------------------------------------------------------------------------------------------------------------------

 10/14/13 114 116

 10/15/13 113 116

 10/16/13 115 116

 10/17/13 116 122

 10/18/13 116 119

 10/19/13 113 122

 10/20/13 112 126

 10/21/13 112 116

 10/22/13 107 136

 10/23/13 107 112

 10/24/13 101 122

 10/25/13 101 109

 10/26/13 102 96

 10/27/13 100 102

 10/28/13 120 109

 10/29/13 118 109

 10/30/13 112 106

 10/31/13 116 109

 11/01/13 116 106

 11/02/13 117 109

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

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 INHALATION TABLE 6

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN CHAMBER VENTILATION RATE [L/MIN]

-----------------------------------------------------------------------------------------------------------------------------------

 GROUP: 0 PPM 10000 PPM

 DATE CHAMBER: 5A 5B

-----------------------------------------------------------------------------------------------------------------------------------

 11/03/13 118 112

 11/04/13 116 112

 11/05/13 116 109

 11/06/13 118 109

 11/07/13 119 99

 11/08/13 124 99

 11/09/13 126 122

 11/10/13 128 109

 11/11/13 122 102

 11/12/13 111 109

 11/13/13 112 102

 11/14/13 116 102

 11/15/13 123 116

 11/16/13 116 102

 11/17/13 117 106

 11/18/13 120 106

 11/19/13 124 112

 11/20/13 114 102

-----------------------------------------------------------------------------------------------------------------------------------

 GRAND MEAN 115 111

 SD 6.7 8.5

 CV(%) 5.83 7.66

 N 38 38

 MANUALv1.0

 12/15/2013

 R:02/07/2014

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

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An Inhalation Reproduction/Developmental

Toxicity Screening Study of 2-Bromo-3,3,3-Trifluoropropene in Rats

Exposure Atmosphere Generation Report

Date Issued

14 March 2014

WIL Research Inhalation Department

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

- Page 1 of 56 - Inhalation Report

 Page 213 of 1107
WIL-65501 

American Pacific Corporation 

REPORT REVIEW AND APPROVAL 

Report Approved by: 

fh==LR 

Arthur J. Stephens, BA 

Biologist, Inhalation Toxicology 

Lead Technician 

Page 2 of 56 Inhalation Report 

 Page 214 of 1107
LIST OF ABBREVIATIONS

The following abbreviations may apply to this report:

%RE - percent relative error

ALC - approximate lethal 

concentration

btm - bottom

CNOS - conventional nose-only 

system

conc. - concentration

CP - commercial product

CVR - chamber ventilation rate

DI - deionized

ECD - electron capture detection

EtOH - ethanol

F - female

FID - flame ionization detection

GC - gas chromatograph

GSD - geometric standard 

deviation

HEPA - high efficiency particulate 

air

HPLC - high performance liquid 

chromatography

hr - hour(s)

IS - internal standard

LLOQ - lower limit of quantitation

L/min - liters per minute

LPM - liters per minute

M - male

MeOH - methanol

mg/m3- milligram per meter cubed

mid - middle

min - minute

MMAD - mass median aerodynamic 

diameter

N - number

NA - not applicable

ND - not detected

NOS - nose-only system

NQ - not quantifiable

NS - no sample

ppm - parts per million

QC - quality control

ref. - reference

RSD - relative standard deviation

SD - standard deviation

SE - standard error

sec - second(s)

SLPM - standard liters per minute

SOP - standard operating 

procedure

TCD - thermal conductivity

detection

theo. - theoretical

UHPLC - ultra-high performance 

liquid chromatography

ULOQ - upper limit of quantitation

UV - ultraviolet

v - volume

w - weight

WDF - Wright Dust Feeder

WINH - Inhalation Exposure Data 

Collection System

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

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TABLE OF CONTENTS

Page

Report Review and Approval ...............................................................................2

List of Abbreviations.............................................................................................3

Table of Contents...................................................................................................4

Index of Figures......................................................................................................5

Index of Tables.......................................................................................................5

1. Introduction............................................................................................................6

1.1. WIL Research Key Study Personnel........................................................................6

1.2. WIL Research Computer Systems - Report Generation..........................................6

2. Exposure Methods .................................................................................................7

2.1. Exposure Regimen...................................................................................................7

2.2. Inhalation Exposure System Description.................................................................7

2.3. Daily Exposure Timing............................................................................................8

2.4. Animal Transport and Placement.............................................................................9

2.5. Exposure Environmental Conditions.......................................................................9

3. Test Atmosphere Generation Methods ..............................................................11

3.1. Exposure Chambers 2, 3, and 4 .............................................................................11

3.2. Exposure Chambers 5B (10,000 ppm)...................................................................12

4. Methods of Characterization of Exposure Atmospheres .................................14

4.1. Analyzed Exposure Concentrations.......................................................................14

4.1.1. Analytical Methods................................................................................................14

4.1.2. Gas Chromatograph Calibration ............................................................................16

4.1.3. Calculation of Test Substance and Exposure Atmosphere Concentrations...........17

4.1.4. Determination of Homogeneity of Exposure Atmospheres...................................18

5. Results of Characterization of Actual Exposure Concentrations....................20

5.1. Exposure Concentrations.......................................................................................20

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

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INDEX OF FIGURES

Page

1. Atmosphere Generation and Exposure System (Chambers 2, 3, and 4)................22

2. Atmosphere Generation and Exposure System (Chamber 5B)..............................23

INDEX OF TABLES

1. Daily Mean Temperature Values [°C]...................................................................25

2. Daily Mean Chamber Temperature [degrees Celsius]...........................................27

3. Daily Mean Humidity Values [%].........................................................................29

4. Daily Mean Chamber Relative Humidity [%] .......................................................31

5. Daily Mean CVR Values [L/min]..........................................................................33

6. Daily Mean Chamber Ventilation Rate [L/min]....................................................35

7. Test Atmosphere Homogeneity Determination .....................................................37

8. Daily Mean Concentration Values for 2-Bromo-3,3,3-Triflu (ppm).....................41

9. Daily Mean Test Atmosphere Concentrations.......................................................49

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

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1. INTRODUCTION

This report presents the inhalation study design, exposure atmosphere generation, and analysis 

methods used during the conduct of this study.

1.1. WIL RESEARCH KEY STUDY PERSONNEL

Arthur J. Stephens, BA Biologist, Inhalation Toxicology

Christine A. Heston, BA Quality Control Coordinator, Inhalation Toxicology

Jason M. Snyder, BS Group Supervisor, Inhalation Toxicology

Daniel T. Kirkpatrick, PhD, DABT Director, Inhalation Toxicology

Andrew J. Smith, BS Group Manager, Inhalation Toxicology

Sarah E. Brockway, BS Data Coordinator, Reporting & Technical Support 

Services

Gregory A. Hawks, AS Group Supervisor, Reporting & Technical Support 

Services

Robert A. Wally, BS Operations Manager, Reporting & Technical Support 

Services

1.2. WIL RESEARCH COMPUTER SYSTEMS - REPORT GENERATION

Program/System Description

Archive Management System (AMS) In-house developed application for storage, maintenance, and 

retrieval of information for archived materials (e.g., lab books, 

study data, wet tissues, slides, etc.).

InSight®Publisher Electronic publishing system (output is Adobe Acrobat, PDF).

Master Schedule Maintains the master schedule for the company.

Metasys DDC Electronic 

Environmental Control System

Controls and monitors animal room environmental conditions.

Microsoft® Office 2007 Used in conjunction with the publishing software to generate 

study reports.

WIL Toxicology Data Management 

SystemTM (WTDMSTM) 

In-house developed system used for collection and reporting 

of in-life and postmortem data.

Note: Version numbers of WTDMSTM programs used for the study are presented on the report data 

tables (reporting programs); version numbers and release dates are otherwise maintained in the study 

records and/or facility records.

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2. EXPOSURE METHODS

2.1. EXPOSURE REGIMEN

The test substance, 2-bromo-3,3,3-trifluoropropene or filtered air (control group) were 

administered as daily 6-hour whole-body inhalation exposures for Groups 1, 2, 3, and 4. The test 

substance was administered as a daily 5-minute whole body exposure for Group 5. A detailed 

description of the study design and exposure schedule is presented in the main report. Table T1

presents the overall schedule for inhalation exposures:

Table T1. Exposure Schedule

Study Day Date

First Exposure 0 14 October 2013

Last Exposure 51 04 December 2013

2.2. INHALATION EXPOSURE SYSTEM DESCRIPTION

Exposures were conducted in four 1.0-m

3

stainless steel and glass for Groups 1, 2, 3, and 4 and 

two 0.5-m

3

stainless steel and glass whole-body inhalation chambers for Group 5. Group 5 

exposure animals were exposed to filtered air (Chamber 5A) prior to a daily 5-minute test 

substance exposure (Chamber 5B). Following the 5-minute exposure, animals were returned to 

Chamber 5A for the duration of the 6-hour exposure period. Chambers were dedicated for the

groups as shown in Table T2.

Table T2. Study Design

Group: 1 2 3 4 5 5

Exposure Chamber: 1 2 3 4 5A 5B

Target Exposure Concentration (ppm): 0 50 100 175 0 10,000

Chamber supply air was provided from a HEPA- and charcoal-filtered, temperature- and 

humidity-controlled source. Treatment of exhaust air consisted of charcoal- and 

HEPA-filtration.

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2.3. DAILY EXPOSURE TIMING

For the 6-hour test substance exposures (Chambers 2, 3, and 4), exposures were initiated when 

the generation system’s 3-way valve, which directed test substance vapor, was switched from 

“Bypass” to “Exposure” and ended after the valve had been in the “Exposure” position for 

6-hours and was switched back to “Bypass” (see Section 3). 

The 5-minute 10,000 ppm group exposures were performed as follows (see schematic below). A 

pre-generation with concentration analysis was performed to insure that the exposure 

concentration was appropriately targeted. When successful pre-generation was achieved, the 

cage batteries with animals were transferred to Chamber 5B (test substance), which was then 

resealed (T = 0 minutes). Since the concentration dropped rapidly during this transfer, a 

4-minute concentration build-up period was allowed in order to re-establish a suitable vapor 

concentration near 10,000 ppm. At T = 4 minutes, a GC sample was collected from Chamber 5B 

and the exposure was started. At the end of the 5-minute exposure period (T = 9 minutes), a 

second GC sample was collected and the batteries with animals were transferred back to 

Chamber 5A (filtered air) for the duration of the 6-hour exposure. All transfers into and out of 

Chamber 5B were performed by technicians equipped with appropriate personal protective 

equipment.

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2.4. ANIMAL TRANSPORT AND PLACEMENT

Animals were housed in a normal animal colony room during non-exposure hours. For each

exposure, the animals were transferred to rat exposure caging, transported to Exposure Room 3 

(Groups 1, 2, 3, and 4) and Exposure Room 5 (Group 5), exposed for the requisite duration, and 

returned to their home cages in the animal colony room. Animals were individually housed in 

stainless steel wire-mesh caging during the exposures. Food and water were withheld during the 

animal exposure period.

2.5. EXPOSURE ENVIRONMENTAL CONDITIONS

For Chambers 1, 2, 3, and 4, temperature, relative humidity, and chamber ventilation rate were

continually monitored and recorded at least hourly during exposure through the use of the 

Inhalation Exposure Data Collection System (WINH) and a personal computer. Chamber 

temperature and relative humidity were monitored using an Omega®temperature and relative 

humidity transmitter probe (model no. HX94C, Omega Engineering, Inc., Stamford, CT). 

Temperature, relative humidity, and chamber ventilation rate were continually monitored and 

manually recorded once during the 5-minute exposure period for Chamber 5B and at least hourly 

for Chamber 5A during the exposure. Chamber temperature and relative humidity were

monitored using an Omega®temperature and relative humidity transmitter probe (model 

no. HX94C, Omega Engineering, Inc., Stamford, CT) and display box. The daily mean 

temperature and mean relative humidity were to be 19°C to 25°C and 30% to 70%, respectively. 

Chambers were operated under dynamic conditions with at least 12 to 15 air changes per hour at 

a slight negative pressure. Chamber airflow was monitored using a sharp edge orifice meter and 

Dwyer Magnehelic®Indicating Transmitter pressure gauge (Dwyer Instruments, Inc., Michigan 

City, IN). Each gauge was calibrated for conversion from pressure to airflow in standard liters 

per minute through the use of a Fox Gas Mass Flowmeter Transmitter (Model FT2, Fox Thermal 

Instruments, Marina, CA). Chamber negative pressure was monitored using a Dwyer 

Magnehelic®Indicating Transmitter pressure gauge (Dwyer Instruments, Inc., Michigan City, 

IN). Daily means for chamber temperature, relative humidity, and ventilation rate over the study 

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

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period are presented in Table 1, Table 2, Table 3, Table 4, Table 5, and Table 6 of this appendix. 

Table T3 summarizes the mean environmental conditions for all chambers:

Table T3. Mean Environmental Conditions

Exposure Chamber: 1 2 3 4 5A 5B

Temperature (°C): 23 22 22 23 23 23

Standard Deviation: 0.7 0.8 0.6 0.7 0.8 0.8

Relative Humidity (%): 59 52 55 54 51 58

Standard Deviation: 2.4 3.0 4.0 4.9 11.6 4.9

Ventilation Rate (LPM): 221 222 223 221 115 111

Standard Deviation: 6.8 6.7 6.4 5.8 6.7 8.5

N: 38 39 40 52 38 38

Oxygen content of the exposure atmospheres was determined during the method development 

phase using a Dräger PAC III calibrated oxygen sensor (serial no. ERRH-0148, Draeger Safety 

Inc., Pittsburgh, PA). The oxygen content for all chambers was at least 19.0%.

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3. TESTATMOSPHERE GENERATION METHODS

3.1. EXPOSURE CHAMBERS 2, 3, AND 4

A single vapor generator was used to produce a vapor and a distribution system was used to 

deliver a controlled amount of test substance to each chamber as shown in Figure 1. The single 

generator consisted of a sealable 4-neck reaction flask (1000 mL) that was filled with an 

appropriate volume of test substance and heated to 29°C to 41°C using a mantle-type heater 

(Glas-Col, LLC, Terre Haute, IN) controlled using a Powerstat variable transformer (model 

no. 3PN116C, Superior Electric, Farmington, CT). Using a regulator (Coilhose Pneumatics, Inc., 

East Brunswick, NJ) and an Omega® digital mass flowmeter (model no. FMA1820), compressed 

nitrogen was metered to 1 port of the reaction flask. Two ports were used to measure both the 

liquid and vapor temperatures separately within the flask. The temperatures were monitored

using separate probes and Omega®PID temperature controllers and process monitors (model 

no. CNi1654). The outlet port was used to deliver test substance vapor to a stainless steel 

mixing-tee through a 3-way valve (bypass valve). With the 3-way valve in the “EXPOSURE” 

position, test substance vapor was directed to the mixing tee where dilution air was added. Using 

a Coilhose regulator (model no. 8802K) and an Omega® digital mass flowmeter (model 

no. FMA1820), compressed air was added to the mixing tee. The test substance atmosphere was

directed from the mixing tee to a stainless steel manifold where it was distributed to each 

exposure chamber using compressed air-powered, adjustable transvector air pumps. Table T4 

summarizes the generation parameters for exposure:

Table T4. Generation Parameters

Nitrogen Flow Rate Dilution Airflow Rate

(Indicated) (LPM)

0.14-0.80 10-12

The vapor generator, distribution manifold, bypass valve and interconnecting Teflon®or 

stainless steel tubing, and fittings were contained within a vented safety cabinet. The air exiting 

the cabinet was connected to the facility exhaust. 

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

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Using Coilhose regulators (model no. 8802K), compressed air was supplied to each transvector 

(VDF-100, Vaccon Company, Inc., Medway, MA) to control the portion of test substance 

atmosphere pulled from the manifold. A metal orifice (O’Keefe Controls Co., Trumbull, CT) 

was placed in-line after the manifold to restrict the flow directed to each transvector. Test 

substance atmosphere was delivered to each chamber inlet via 3/8-inch polyethylene lines. 

Chamber supply air was added to the chamber inlet where it mixed with the test substance 

atmosphere to produce the desired exposure concentration prior to entering the chamber. 

Table T5 summarizes the transvector parameters settings for each test substance chamber:

Table T5. Transvector Parameters

Chamber Orifice no. Transvector Setting

(psi)

2 35 10.5-14.0

3 63 6.5-12.0

4 73 10.0-16.0

3.2. EXPOSURE CHAMBERS 5B (10,000 PPM)

A single vapor generator was used to produce a vapor atmosphere as shown in Figure 2. A

500-mL gas washing bottle, filled with an initial appropriate amount of test substance, was

heated in an oil bath. The oil bath (Fisher Scientific Isotemp [model no. 102, Fisher Scientific, 

Waltham, MA]) was heated to between 63°C and 86°C monitored with a J-Type thermocouple, 

and controlled using an Omega®PID temperature controller and process monitor (model 

no. CNi1654) (read-out only). Using an FMI Lab pump (model no. QG 20, Fluid Metering, Inc., 

Syosset, NY), additional test substance was delivered at a constant rate from the reservoir to the 

gas washing bottle. Using a Coilhose Pneumatics regulator (model no. 8802K) and a 

rotameter-type flowmeter (model no. PMR1-010649, Cole-Parmer, Vernon Hills, IL), 

compressed nitrogen was metered through a tube heater to the inlet of the gas washing bottle. 

The tube heater was heated to 89°C to 114°C, monitored using a J-Type thermocouple, and

controlled using an Omega®PID temperature controller and process monitor (model 

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

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no. CNi1654). Nitrogen was metered into the inlet stem of the gas washing bottle where it 

passed through a fritted disk and bubbled through the liquid test substance to produce vapors of 

the test substance. Test substance vapor from the gas washing bottle was delivered to the 

chamber inlet via 1⁄4-inch polyethylene line. Chamber supply air was added to the chamber inlet 

where it mixed with the test substance vapor to produce the desired exposure concentration prior 

to entering the chamber. The vapor generator and test atmosphere exposure chamber was

contained within a vented hood. Table T6 summarizes the generation parameters:

Table T6. Generation Parameters

Nitrogen Flow Rate Test Substance Delivery Rate

(LPM) (mL/minute)

8.9-13 5.2-7.6

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4. METHODS OF CHARACTERIZATION OF EXPOSURE ATMOSPHERES

4.1. ANALYZED EXPOSURE CONCENTRATIONS

4.1.1. ANALYTICAL METHODS

Analyzed exposure concentrations were determined at approximately 60-minute intervals using a 

GC. Samples were collected from the approximate animal-breathing zone of the inhalation 

exposure chambers via 1⁄8-inch stainless steel tubing. For Chambers 1, 2, 3, and 4, samples were 

collected under the control of the WINH data acquisition software application and sampling and 

analyses were performed as follows. The program controlled an external multi-position valve 

(Model E16, Valco Instruments Co., Inc., Houston, TX) that permits sequential sampling from 

the exposure room and each exposure chamber. Gas sample injection onto the chromatography 

column occurred via an internal gas-sampling valve with sample loop; the chromatograph was 

displayed and the area under the sample peak was calculated and stored. The WINH program 

then acquired the stored peak area data and used an ln-quadratic equation based on the GC 

calibration curve to calculate the measured concentrations in parts per million (ppm). The 

following table summarizes the operational parameters used for the GC methods for Chambers 1, 

2, 3, and 4.

Equipment

GC: Hewlett Packard 5890 Series II

GC Detector: FID

GC Column: Agilent DB-5

30 m × 0.530 mm ID, 1.5-micron film-thickness

Integrator: Agilent Model 3396 Series II

GC Gases Pressure Approximate Flow Rate

(psig) (mL/minute)

Carrier - Helium: 20 10 ± 1

Fuel - Hydrogen: 15 32 ± 3

Air: 30 290 ± 10

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GC Temperatures (°C)

Column: 25

Detector: 350

Integrator Run Parameters

Chart Zero Offset: 0

Chart Attenuation: 3

Chart Speed: 1.0 cm/minute

Peak Area Rejection Value: 0

Peak Threshold: 4

Peak Width: 0.05

Retention Time: Approximately 1.7 minutes

For Chambers 5A and 5B, analytical samples were manually collected approximately hourly and 

twice during the test substance exposure, respectively, using an external multi-position valve 

(Model E16, Valco Instruments Co., Inc., Houston, TX) that permits sequential sampling from 

the exposure room and each exposure chamber. Gas sample injection onto the chromatography 

column occurred via an internal gas-sampling valve with sample loop, the chromatograph was 

displayed and the area under the sample peak was calculated and stored. The ln-quadratic 

equation based on the GC calibration curve was used to calculate the measured concentrations in 

parts per million (ppm). The following table summarizes the operational parameters used for the 

GC methods for Chambers 5A and 5B.

Equipment

GC: Hewlett Packard 5890 Series II

GC Detector: FID

GC Column: Agilent DB-5

30 m × 0.530 mm ID, 1.5-micron film-thickness

Integrator: Agilent Model 3396 Series II

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GC Gases Pressure Approximate Flow Rate

(psig) (mL/minute)

Carrier - Helium: 27.5 10 ± 1

Fuel - Hydrogen: 30 32 ± 3

Air: 32.5 290 ± 10

GC Temperatures (°C)

Column: 25

Detector: 350

Integrator Run Parameters

Chart Zero Offset: 0

Chart Attenuation: 10

Chart Speed: 1.0 cm/minute

Peak Area Rejection Value: 0

Peak Threshold: 6

Peak Width: 0.05

Retention Time: Approximately 1.6 minutes

4.1.2. GAS CHROMATOGRAPH CALIBRATION

The GC was calibrated using gas-phase standards prepared to contain a known vapor 

concentration of the test substance in 10-L or 25-L Tedlar®gas bags (SKC, Inc., Eighty Four,

PA). Standards were prepared by injecting a known volume of liquid test substance into the 

standard bag filled with the appropriate amount of compressed air. A dry test meter 

(DTM-200A, Elster American Meter Co., Nebraska City, NE) was used to measure the total 

volume of air. The standard bag was manually agitated prior to sampling and then placed on the 

appropriate valve position and sampled for 2 minutes prior to being analyzed by the GC. 

Concentrations of the gas-phase standards were calculated as follows:

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Concentration (ppm) =

WT × MV × 106

GMW × VOL × DEN

Where:

WT = Injection volume from basis bag, mL

MV = Molar volume at 730 mmHg and 21oC, 25.11 L/mol

106= ppm conversion factor

GMW Gram molecular weight, 174.950 g/mol

VOL Volume of air injected into standard bag, L

DEN Density, 1.686 g/mL

4.1.3. CALCULATION OF TEST SUBSTANCE AND EXPOSURE ATMOSPHERE 

CONCENTRATIONS

The GC was calibrated with standards prepared and analyzed in triplicate. One calibration curve 

was prepared for Chambers 1, 2, 3, and 4 using 4 vapor concentrations spanning an appropriate 

range relative to the target exposure concentration. A second calibration curve was prepared for 

Chambers 5A and 5B using 3 vapor concentrations spanning an appropriate range relative to the 

target exposure concentration. The peak area (y) and the theoretical concentrations (x) of the 

calibration standards were fit with least-squares regression analysis to the ln-quadratic function: 

ln (y) = a × [ln (x)]2+ b × ln (x) + c

Prior to the initiation of the exposure, at least 1 standard was prepared and analyzed to perform a 

calibration check of the GC. The GC was considered to be in calibration if the analyzed 

concentration of the prepared standard was within ± 10% of the known concentration. Table T7

lists the standards used for the Chamber 1, 2, 3, and 4 calibration curve (A) and Chamber 5A and 

5B calibration curve (B):

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Table T7. Calibration Curve Standards

Calibration Curve Standard Concentration Test Substance Volume Dilution Air Volume

(ppm) (μL) (L)

A 36 3 20

A 48 4 20

A 121 10 20

A 254 21 20

B 4,992 165 8

B 9,984 330 8

B 15,127 500 8

4.1.4. DETERMINATION OF HOMOGENEITY OF EXPOSURE ATMOSPHERES

Homogeneity of exposure concentrations was evaluated during the method development phase of 

the study. Two or 4 test locations and a reference location were used for these determinations. 

Samples were collected and analyzed on the GC as rapidly as possible by alternating from the 

reference location and then to a test location. Homogeneity was performed in triplicate for each 

test substance exposure chamber. The measured concentration was calculated as a percent 

difference for each position from the reference location. The results of homogeneity 

determination are presented in Table 7 of this appendix. Table T8 summarizes the mean data of 

the replicates for the test substance chambers: 

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Table T8. Mean Homogeneity Determinations

Exposure System Test Location Mean % from Reference

2 Upper Front -2.7

Lower Front -1.3

Upper Rear -1.4

Lower Rear -2.8

3 Upper Front 0.3

Lower Front -0.7

Upper Rear -2.1

Lower Rear -1.0

4 Upper Front -0.4

Lower Front -1.2

Upper Rear -1.7

Lower Rear -1.7

5B Upper Front 1.0

Lower Rear 1.7

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5. RESULTS OF CHARACTERIZATION OFACTUAL EXPOSURE CONCENTRATIONS

5.1. EXPOSURE CONCENTRATIONS

The analyzed concentrations for each chamber are presented in Table 8 and Table 9 of this 

appendix. Table T9 summarizes the overall mean analyzed concentrations of each chamber:

Table T9. Overall Mean Exposure Concentrations

Exposure Chamber: 1 2 3 4 5A 5B*

Target Concentration (ppm): 0 50 100 175 0 10,000

Mean Concentration (ppm): 0 50 101 174 0 10,076

Standard Deviation: 0.0 3.2 4.8 10.7 0.0 607.9

N: 38 39 40 52 38 38

* = Mean obtained from T=4 minutes and T=9 minutes. See Section 2.3 for clarification.

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FIGURES

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Figure 1. Atmosphere Generation and Exposure System (Chambers 2, 3, and 4)

* = items pictured for Chamber 2 only, but is repeated for Chambers 3 and 4

Transvector Jet Compressed Air* Regulator* Orifice 1000-L Whole-Body Chamber*

Supply Air Source*

Orifice Plate*

To Exhaust*

Liquid Temperature

Vapor Temperature

Compressed Nitrogen Mantle Heater

Compressed Air Rotameter

TA

Flask

30-40°C

Negative Pressure Safety Cabinet

To Exhaust

Regulator

By-Pass Line to Exhaust

Variac Controller

To Exhaust

To

Ch.3 ToCh.4

°C

Rotameter

Manifold

Rotameter

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Figure 2. Atmosphere Generation and Exposure System (Chamber 5B)

Compressed Nitrogen

FMI Pump

Test Substance Reservoir

Gas Washing Bottle in Heated Oil Bath

500-L Whole-Body Chamber

Supply Air Source

Orifice Plate

To Exhaust

Heated Tube Heater

Rotameter and Regulator

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TABLES aaaaa 

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American Pacific Corporation

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PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

INHALATION TABLE 1

-----------------------------------------------------------------------------------------------------------------------------------

DAILY MEAN TEMPERATURE VALUES (°C)

RUN DATE 0 PPM 50 PPM 100 PPM 175 PPM

------------------------------------------------------------------------------------------------------------------------------------

14-OCT-2013 23.1 23.0 21.9 22.9

15-OCT-2013 21.8 21.8 21.0 22.0

16-OCT-2013 22.5 22.1 21.7 22.9

17-OCT-2013 23.0 23.0 22.0 23.1

18-OCT-2013 21.7 21.5 20.8 21.8

19-OCT-2013 22.4 22.2 21.7 23.0

20-OCT-2013 22.9 23.0 21.9 22.9

21-OCT-2013 22.4 21.9 21.5 22.4

22-OCT-2013 22.5 22.1 21.9 23.1

23-OCT-2013 23.3 23.3 22.2 23.3

24-OCT-2013 21.8 21.7 21.2 22.3

25-OCT-2013 22.4 22.1 21.8 23.2

26-OCT-2013 23.2 23.3 22.4 23.5

27-OCT-2013 21.9 21.9 21.3 22.5

28-OCT-2013 22.6 22.3 22.0 23.3

29-OCT-2013 23.2 23.3 22.3 23.3

30-OCT-2013 21.7 21.2 21.1 22.4

31-OCT-2013 22.6 22.2 21.9 23.2

01-NOV-2013 23.6 23.3 22.3 23.6

02-NOV-2013 22.5 22.3 21.7 22.9

03-NOV-2013 23.0 22.5 22.1 23.7

04-NOV-2013 23.4 23.3 22.4 23.7

05-NOV-2013 22.4 22.7 21.6 22.9

06-NOV-2013 23.0 22.3 22.1 23.4

07-NOV-2013 24.1 23.6 22.8 23.8

08-NOV-2013 22.4 22.1 21.7 22.9

09-NOV-2013 23.3 22.6 22.7 23.7

10-NOV-2013 24.1 23.8 22.9 23.9

WIL Research Laboratories, LLC

Report File: TemperatureSummary v1.09.rpt (04-10-13), WINH version 1.24 Printed On: 17-Dec-2013 15:16 

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

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INHALATION TABLE 1

-----------------------------------------------------------------------------------------------------------------------------------

DAILY MEAN TEMPERATURE VALUES (°C)

RUN DATE 0 PPM 50 PPM 100 PPM 175 PPM

------------------------------------------------------------------------------------------------------------------------------------

11-NOV-2013 22.0 21.4 21.2 22.2

12-NOV-2013 22.9 22.3 22.3 23.4

13-NOV-2013 21.2 21.0 21.0 22.1

14-NOV-2013 21.2 20.8 20.7 21.8

15-NOV-2013 22.5 22.1 22.2 23.5

16-NOV-2013 21.9 21.5 21.3 22.2

17-NOV-2013 21.8 21.4 21.2 22.3

18-NOV-2013 23.0 22.4 22.3 23.7

19-NOV-2013 21.8 21.4 21.2 22.4

20-NOV-2013 21.2 20.7 20.7 21.8

21-NOV-2013 NA 21.5 21.2 22.5

22-NOV-2013 NA NA 21.1 22.2

23-NOV-2013 NA NA NA 22.2

24-NOV-2013 NA NA NA 22.7

25-NOV-2013 NA NA NA 22.6

26-NOV-2013 NA NA NA 22.3

27-NOV-2013 NA NA NA 22.7

28-NOV-2013 NA NA NA 22.6

29-NOV-2013 NA NA NA 22.3

30-NOV-2013 NA NA NA 23.6

01-DEC-2013 NA NA NA 21.1

02-DEC-2013 NA NA NA 21.4

03-DEC-2013 NA NA NA 21.5

04-DEC-2013 NA NA NA 21.3

GRAND MEAN: 22.5 22.2 21.7 22.7

SD:

N:

0.74 0.79 0.59 0.71

38 39 40 52

WIL Research Laboratories, LLC

Report File: TemperatureSummary v1.09.rpt (04-10-13), WINH version 1.24 Printed On: 17-Dec-2013 15:16 

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

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 INHALATION TABLE 2

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN CHAMBER TEMPERATURE [DEGREES CELSIUS]

-----------------------------------------------------------------------------------------------------------------------------------

 GROUP: 0 PPM 10000 PPM

 DATE CHAMBER: 5A 5B

-----------------------------------------------------------------------------------------------------------------------------------

 10/14/13 23 22

 10/15/13 23 21

 10/16/13 23 23

 10/17/13 25 25

 10/18/13 23 28

 10/19/13 23 22

 10/20/13 22 22

 10/21/13 23 23

 10/22/13 23 22

 10/23/13 23 23

 10/24/13 25 23

 10/25/13 24 23

 10/26/13 24 22

 10/27/13 24 23

 10/28/13 23 23

 10/29/13 23 23

 10/30/13 23 23

 10/31/13 23 24

 11/01/13 24 23

 11/02/13 24 22

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 INHALATION TABLE 2

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN CHAMBER TEMPERATURE [DEGREES CELSIUS]

-----------------------------------------------------------------------------------------------------------------------------------

 GROUP: 0 PPM 10000 PPM

 DATE CHAMBER: 5A 5B

-----------------------------------------------------------------------------------------------------------------------------------

 11/03/13 24 23

 11/04/13 24 23

 11/05/13 24 23

 11/06/13 24 23

 11/07/13 24 23

 11/08/13 24 23

 11/09/13 25 23

 11/10/13 24 22

 11/11/13 24 22

 11/12/13 23 22

 11/13/13 23 21

 11/14/13 23 23

 11/15/13 23 23

 11/16/13 23 22

 11/17/13 22 22

 11/18/13 23 22

 11/19/13 22 22

 11/20/13 22 21

-----------------------------------------------------------------------------------------------------------------------------------

 GRAND MEAN 23 23

 SD 0.8 1.2

 CV(%) 3.48 5.22

 N 38 38

 MANUALv1.0

 12/15/2013

 R:12/16/2013

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INHALATION TABLE 3

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

-----------------------------------------------------------------------------------------------------------------------------------

DAILY MEAN HUMIDITY VALUES (%)

RUN DATE 0 PPM 50 PPM 100 PPM 175 PPM

-----------------------------------------------------------------------------------------------------------------------------------

14-OCT-2013 63.8 48.0 53.3 53.8

15-OCT-2013 60.0 51.2 56.6 52.1

16-OCT-2013 58.4 49.8 54.5 52.0

17-OCT-2013 59.2 48.2 54.7 51.9

18-OCT-2013 60.3 51.5 56.8 52.3

19-OCT-2013 57.8 52.9 56.9 54.9

20-OCT-2013 56.4 45.9 52.5 50.3

21-OCT-2013 58.8 51.4 55.6 51.9

22-OCT-2013 55.6 51.7 53.9 52.7

23-OCT-2013 58.0 47.6 53.6 53.9

24-OCT-2013 57.0 50.3 53.2 52.0

25-OCT-2013 57.2 52.1 55.6 54.2

26-OCT-2013 57.7 48.5 53.7 52.8

27-OCT-2013 59.1 51.9 56.2 53.6

28-OCT-2013 56.2 50.4 54.9 53.0

29-OCT-2013 59.1 49.1 54.3 54.4

30-OCT-2013 63.6 56.8 53.1 60.9

31-OCT-2013 58.5 52.3 53.2 55.1

01-NOV-2013 57.3 48.4 43.3 55.1

02-NOV-2013 58.7 53.0 45.2 55.4

03-NOV-2013 55.7 52.7 41.4 53.8

04-NOV-2013 57.8 49.0 53.4 53.1

05-NOV-2013 58.8 53.6 55.6 55.4

06-NOV-2013 60.2 54.1 58.9 59.4

07-NOV-2013 58.4 48.6 53.5 55.2

08-NOV-2013 55.9 51.5 54.7 52.4

09-NOV-2013 55.4 50.9 54.2 52.6

10-NOV-2013 56.3 48.2 53.6 53.6

11-NOV-2013 57.8 52.6 56.4 55.2

WIL Research Laboratories, LLC

Report File: HumiditySummary v1.09.rpt (04-10-13), WINH version 1.24 Printed On: 17-Dec-2013 15:16 

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INHALATION TABLE 3

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

-----------------------------------------------------------------------------------------------------------------------------------

DAILY MEAN HUMIDITY VALUES (%)

RUN DATE 0 PPM 50 PPM 100 PPM 175 PPM

-----------------------------------------------------------------------------------------------------------------------------------

12-NOV-2013 56.0 50.8 54.6 53.0

13-NOV-2013 63.0 57.3 57.6 58.0

14-NOV-2013 61.6 57.1 59.4 59.3

15-NOV-2013 59.8 51.9 56.0 56.4

16-NOV-2013 59.0 53.6 56.7 56.7

17-NOV-2013 59.5 53.6 56.8 55.0

18-NOV-2013 59.5 53.4 57.1 56.6

19-NOV-2013 60.4 54.7 58.5 56.0

20-NOV-2013 65.6 60.3 62.8 62.7

21-NOV-2013 NA 53.2 58.5 65.7

22-NOV-2013 NA NA 58.6 58.8

23-NOV-2013 NA NA NA 29.1

24-NOV-2013 NA NA NA 47.9

25-NOV-2013 NA NA NA 50.6

26-NOV-2013 NA NA NA 53.6

27-NOV-2013 NA NA NA 51.0

28-NOV-2013 NA NA NA 52.2

29-NOV-2013 NA NA NA 53.6

30-NOV-2013 NA NA NA 50.7

01-DEC-2013 NA NA NA 58.5

02-DEC-2013 NA NA NA 57.5

03-DEC-2013 NA NA NA 58.9

04-DEC-2013 NA NA NA 60.0

N:

GRAND MEAN: 58.8 51.7 54.7 54.3

SD:

CV (%):

2.38 2.99 3.96 4.89

38 39 40 52

4.048 5.783 7.239 9.006

WIL Research Laboratories, LLC

Report File: HumiditySummary v1.09.rpt (04-10-13), WINH version 1.24 Printed On: 17-Dec-2013 15:16 

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

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 INHALATION TABLE 4

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN CHAMBER RELATIVE HUMIDITY [%]

-----------------------------------------------------------------------------------------------------------------------------------

 GROUP: 0 PPM 10000 PPM

 DATE CHAMBER: 5A 5B

-----------------------------------------------------------------------------------------------------------------------------------

 10/14/13 52 60

 10/15/13 53 56

 10/16/13 54 59

 10/17/13 37 50

 10/18/13 28 51

 10/19/13 30 61

 10/20/13 30 51

 10/21/13 31 60

 10/22/13 30 51

 10/23/13 29 61

 10/24/13 23 58

 10/25/13 56 56

 10/26/13 60 51

 10/27/13 58 61

 10/28/13 56 60

 10/29/13 58 62

 10/30/13 61 61

 10/31/13 55 63

 11/01/13 57 58

 11/02/13 60 76

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 INHALATION TABLE 4

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN CHAMBER RELATIVE HUMIDITY [%]

-----------------------------------------------------------------------------------------------------------------------------------

 GROUP: 0 PPM 10000 PPM

 DATE CHAMBER: 5A 5B

-----------------------------------------------------------------------------------------------------------------------------------

 11/03/13 58 60

 11/04/13 58 62

 11/05/13 57 59

 11/06/13 59 61

 11/07/13 58 60

 11/08/13 56 61

 11/09/13 54 59

 11/10/13 62 60

 11/11/13 57 59

 11/12/13 54 58

 11/13/13 52 53

 11/14/13 56 56

 11/15/13 55 51

 11/16/13 53 54

 11/17/13 60 61

 11/18/13 61 60

 11/19/13 59 51

 11/20/13 60 58

-----------------------------------------------------------------------------------------------------------------------------------

 GRAND MEAN 51 58

 SD 011.6 14.9

 CV(%) 22.75 8.45

 N 38 38

 MANUALv1.0

 12/16/2013

 R:12/16/2013

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PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

INHALATION TABLE 5

-----------------------------------------------------------------------------------------------------------------------------------

DAILY MEAN CVR VALUES (L/MIN)

RUN DATE 0 PPM 50 PPM 100 PPM 175 PPM

-----------------------------------------------------------------------------------------------------------------------------------

14-OCT-2013 212 227 222 224

15-OCT-2013 211 226 222 223

16-OCT-2013 212 226 223 222

17-OCT-2013 213 227 223 221

18-OCT-2013 212 227 223 219

19-OCT-2013 215 226 236 213

20-OCT-2013 217 225 228 219

21-OCT-2013 211 221 224 221

22-OCT-2013 216 213 225 219

23-OCT-2013 218 210 215 221

24-OCT-2013 211 211 234 218

25-OCT-2013 225 227 227 227

26-OCT-2013 230 219 219 222

27-OCT-2013 227 218 221 219

28-OCT-2013 224 222 229 222

29-OCT-2013 225 229 235 215

30-OCT-2013 215 222 224 224

31-OCT-2013 214 223 223 217

01-NOV-2013 218 225 226 226

02-NOV-2013 222 228 230 219

03-NOV-2013 226 227 236 224

04-NOV-2013 226 222 228 232

05-NOV-2013 220 215 221 224

06-NOV-2013 218 224 220 223

07-NOV-2013 220 226 220 225

08-NOV-2013 229 235 229 231

09-NOV-2013 234 240 234 232

10-NOV-2013 233 222 226 233

11-NOV-2013 228 220 221 233

WIL Research Laboratories, LLC

Report File: CVRSummary v1.07.rpt (06-06-12), WINH version 1.24 Printed On: 18-Dec-2013 8:25 

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

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PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

INHALATION TABLE 5

-----------------------------------------------------------------------------------------------------------------------------------

DAILY MEAN CVR VALUES (L/MIN)

RUN DATE 0 PPM 50 PPM 100 PPM 175 PPM

-----------------------------------------------------------------------------------------------------------------------------------

12-NOV-2013 230 220 222 233

13-NOV-2013 230 219 223 227

14-NOV-2013 225 216 219 221

15-NOV-2013 220 212 214 222

16-NOV-2013 226 215 218 224

17-NOV-2013 227 216 218 224

18-NOV-2013 225 213 215 221

19-NOV-2013 223 210 217 221

20-NOV-2013 223 219 219 221

21-NOV-2013 NA 216 214 217

22-NOV-2013 NA NA 208 211

23-NOV-2013 NA NA NA 220

24-NOV-2013 NA NA NA 215

25-NOV-2013 NA NA NA 212

26-NOV-2013 NA NA NA 213

27-NOV-2013 NA NA NA 213

28-NOV-2013 NA NA NA 213

29-NOV-2013 NA NA NA 212

30-NOV-2013 NA NA NA 215

01-DEC-2013 NA NA NA 218

02-DEC-2013 NA NA NA 223

03-DEC-2013 NA NA NA 219

04-DEC-2013 NA NA NA 215

N:

GRAND MEAN: 221 222 223 221

SD:

CV (%):

6.8 6.7 6.4 5.8

38 39 40 52

3.08 3.02 2.87 2.62

WIL Research Laboratories, LLC

Report File: CVRSummary v1.07.rpt (06-06-12), WINH version 1.24 Printed On: 18-Dec-2013 8:25 

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

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 INHALATION TABLE 6

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN CHAMBER VENTILATION RATE [L/MIN]

-----------------------------------------------------------------------------------------------------------------------------------

 GROUP: 0 PPM 10000 PPM

 DATE CHAMBER: 5A 5B

-----------------------------------------------------------------------------------------------------------------------------------

 10/14/13 114 116

 10/15/13 113 116

 10/16/13 115 116

 10/17/13 116 122

 10/18/13 116 119

 10/19/13 122 113

 10/20/13 112 126

 10/21/13 112 116

 10/22/13 107 136

 10/23/13 107 112

 10/24/13 101 122

 10/25/13 101 109

 10/26/13 102 96

 10/27/13 100 102

 10/28/13 120 109

 10/29/13 118 109

 10/30/13 112 106

 10/31/13 116 109

 11/01/13 116 106

 11/02/13 117 109

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

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 INHALATION TABLE 6

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN CHAMBER VENTILATION RATE [L/MIN]

-----------------------------------------------------------------------------------------------------------------------------------

 GROUP: 0 PPM 10000 PPM

 DATE CHAMBER: 5A 5B

-----------------------------------------------------------------------------------------------------------------------------------

 11/03/13 118 112

 11/04/13 116 112

 11/05/13 116 109

 11/06/13 118 109

 11/07/13 119 99

 11/08/13 124 99

 11/09/13 126 122

 11/10/13 128 109

 11/11/13 122 102

 11/12/13 111 109

 11/13/13 112 102

 11/14/13 116 102

 11/15/13 123 116

 11/16/13 116 102

 11/17/13 117 106

 11/18/13 120 106

 11/19/13 124 112

 11/20/13 114 102

-----------------------------------------------------------------------------------------------------------------------------------

 GRAND MEAN 115 111

 SD 6.8 8.3

 CV(%) 35.91 7.48

 N 38 38

 MANUALv1.0

 12/15/2013

 R:12/16/2013

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

- Page 36 of 56 - Inhalation Report

Page 248 of 1107
 INHALATION TABLE 7

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. TEST ATMOSPHERE HOMOGENEITY DETERMINATION

---------------------------------------------------------------------------------------------------------------------------------

 TARGET: 50 PPM CHAMBER 2

---------------------------------------------------------------------------------------------------------------------------------

 DATE SAMPLING LOCATION CONCENTRATION (PPM) % FROM REFERENCE MEAN %

---------------------------------------------------------------------------------------------------------------------------------

 08 OCT 2013 REFERENCE PORT 51

 UPPER FRONT 50 -2.0

 REFERENCE PORT 49

 UPPER FRONT 47 -4.1

 REFERENCE PORT 47

 UPPER FRONT 46 -2.1 -2.7

 REFERENCE PORT 51

 LOWER FRONT 50 -2.0

 REFERENCE PORT 49

 LOWER FRONT 47 -4.1

 REFERENCE PORT 47

 LOWER FRONT 48 2.1 -1.3

 REFERENCE PORT 50

 UPPER REAR 50 0.0

 REFERENCE PORT 49

 UPPER REAR 47 -4.1

 REFERENCE PORT 47

 UPPER REAR 47 0.0 -1.4

 REFERENCE PORT 50

 LOWER REAR 50 0.0

 REFERENCE PORT 49

 LOWER REAR 47 -4.1

 REFERENCE PORT 47

 LOWER REAR 45 -4.3 -2.8

--------------------------------------------------------------------------------------------------------------------------------

 PPM = PARTS PER MILLION

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

- Page 37 of 56 - Inhalation Report

Page 249 of 1107
 INHALATION TABLE 7

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. TEST ATMOSPHERE HOMOGENEITY DETERMINATION

---------------------------------------------------------------------------------------------------------------------------------

 TARGET: 100 PPM CHAMBER 3

---------------------------------------------------------------------------------------------------------------------------------

 DATE SAMPLING LOCATION CONCENTRATION (PPM) % FROM REFERENCE MEAN %

---------------------------------------------------------------------------------------------------------------------------------

 08 OCT 2013 REFERENCE PORT 96

 UPPER FRONT 97 1.0

 REFERENCE PORT 91

 UPPER FRONT 92 1.1

 REFERENCE PORT 92

 UPPER FRONT 91 -1.1 0.3

 REFERENCE PORT 96

 LOWER FRONT 96 0.0

 REFERENCE PORT 91

 LOWER FRONT 90 -1.1

 REFERENCE PORT 92

 LOWER FRONT 91 -1.1 -0.7

 REFERENCE PORT 96

 UPPER REAR 91 -5.2

 REFERENCE PORT 89

 UPPER REAR 90 1.1

 REFERENCE PORT 94

 UPPER REAR 92 -2.1 -2.1

 REFERENCE PORT 96

 LOWER REAR 93 -3.1

 REFERENCE PORT 89

 LOWER REAR 90 1.1

 REFERENCE PORT 94

 LOWER REAR 93 -1.1 -1.0

--------------------------------------------------------------------------------------------------------------------------------

 PPM = PARTS PER MILLION

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

- Page 38 of 56 - Inhalation Report

Page 250 of 1107
 INHALATION TABLE 7

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. TEST ATMOSPHERE HOMOGENEITY DETERMINATION

---------------------------------------------------------------------------------------------------------------------------------

 TARGET: 175 PPM CHAMBER 4

---------------------------------------------------------------------------------------------------------------------------------

 DATE SAMPLING LOCATION CONCENTRATION (PPM) % FROM REFERENCE MEAN %

---------------------------------------------------------------------------------------------------------------------------------

 08 OCT 2013 REFERENCE PORT 163

 UPPER FRONT 165 1.2

 REFERENCE PORT 165

 UPPER FRONT 163 -1.2

 REFERENCE PORT 162

 UPPER FRONT 160 -1.2 -0.4

 REFERENCE PORT 163

 LOWER FRONT 164 0.6

 REFERENCE PORT 165

 LOWER FRONT 162 -1.8

 REFERENCE PORT 162

 LOWER FRONT 158 -2.5 -1.2

 REFERENCE PORT 163

 UPPER REAR 162 -0.6

 REFERENCE PORT 162

 UPPER REAR 159 -1.9

 REFERENCE PORT 161

 UPPER REAR 157 -2.5 -1.7

 REFERENCE PORT 163

 LOWER REAR 162 -0.6

 REFERENCE PORT 162

 LOWER REAR 159 -1.9

 REFERENCE PORT 161

 LOWER REAR 157 -2.5 -1.7

--------------------------------------------------------------------------------------------------------------------------------

 PPM = PARTS PER MILLION

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

- Page 39 of 56 - Inhalation Report

Page 251 of 1107
 INHALATION TABLE 7

PROJECT NO.:WIL-65501 RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. TEST ATMOSPHERE HOMOGENEITY DETERMINATION

---------------------------------------------------------------------------------------------------------------------------------

 TARGET: 10,000 PPM CHAMBER 5B

---------------------------------------------------------------------------------------------------------------------------------

 DATE SAMPLING LOCATION CONCENTRATION (PPM) % FROM REFERENCE MEAN %

---------------------------------------------------------------------------------------------------------------------------------

 21 NOV 2013 REFERENCE PORT 10,206

 UPPER FRONT 10,259 0.5

 REFERENCE PORT 10,079

 UPPER FRONT 10,155 0.8

 REFERENCE PORT 9,942

 UPPER FRONT 10,102 1.6 1.0

 REFERENCE PORT 10,206

 LOWER REAR 10,235 0.3

 REFERENCE PORT 10,079

 LOWER REAR 10,324 2.4

 REFERENCE PORT 9,942

 LOWER REAR 10,171 2.3 1.7

--------------------------------------------------------------------------------------------------------------------------------

 PPM = PARTS PER MILLION

 MANUALv1.0

 01/27/2014

 R:01/27/2014

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

- Page 40 of 56 - Inhalation Report

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PROJECT NO.:WIL-65501 PAGE 1

INHALTION TABLE 8

RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE

-----------------------------------------------------------------------------------------------------------------------------------

DAILY MEAN CONCENTRATION VALUES FOR 2-BROMO-3,3,3-TRIFLU (PPM)

RUN DATE 0 PPM 50 PPM 100 PPM 175 PPM

-----------------------------------------------------------------------------------------------------------------------------------

14-OCT-2013 0 49 100 171

0.0 2.1 4.8 7.9

NA 4.29 4.80 4.62

6 6 6 6

SD

CV

N

15-OCT-2013 0 56 106 170

0.0 4.2 7.8 12.1

NA 7.50 7.36 7.12

6 6 6 6

SD

CV

N

16-OCT-2013 0 55 107 183

0.0 1.3 4.2 12.9

NA 2.36 3.93 7.05

6 6 6 6

SD

CV

N

17-OCT-2013 0 47 103 176

0.0 4.1 6.6 12.0

NA 8.72 6.41 6.82

6 6 6 6

SD

CV

N

18-OCT-2013 0 49 100 180

0.0 2.3 3.9 5.3

NA 4.69 3.90 2.94

6 6 6 6

SD

CV

N

19-OCT-2013 0 51 99 182

0.0 3.7 8.3 11.5

NA 7.25 8.38 6.32

6 6 6 6

SD

CV

N

20-OCT-2013 0 50 102 163

0.0 2.5 5.9 26.8

NA 5.00 5.78 16.44

6 6 6 6

SD

CV

N

WIL Research Laboratories, LLC

Report File: CncSummary v1.09.rpt (04-24-13), WINH version 1.24 Printed On: 17-Dec-2013 15:13 

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

- Page 41 of 56 - Inhalation Report

Page 253 of 1107
PROJECT NO.:WIL-65501 PAGE 2

INHALTION TABLE 8

RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE

-----------------------------------------------------------------------------------------------------------------------------------

DAILY MEAN CONCENTRATION VALUES FOR 2-BROMO-3,3,3-TRIFLU (PPM)

RUN DATE 0 PPM 50 PPM 100 PPM 175 PPM

-----------------------------------------------------------------------------------------------------------------------------------

21-OCT-2013 0 53 104 183

0.0 2.5 3.8 14.3

NA 4.72 3.65 7.81

6 6 6 6

SD

CV

N

22-OCT-2013 0 52 99 186

0.0 3.5 6.0 7.7

NA 6.73 6.06 4.14

6 6 6 6

SD

CV

N

23-OCT-2013 0 54 110 185

0.0 1.8 5.5 18.7

NA 3.33 5.00 10.11

6 6 6 6

SD

CV

N

24-OCT-2013 0 49 90 176

0.0 2.1 5.4 12.6

NA 4.29 6.00 7.16

6 6 6 6

SD

CV

N

25-OCT-2013 0 45 98 157

0.0 4.2 7.1 12.0

NA 9.33 7.24 7.64

6 6 6 6

SD

CV

N

26-OCT-2013 0 52 96 173

0.0 4.6 8.0 14.0

NA 8.85 8.33 8.09

6 6 6 6

SD

CV

N

27-OCT-2013 0 52 103 192

0.0 3.1 12.7 6.2

NA 5.96 12.33 3.23

6 6 6 6

SD

CV

N

WIL Research Laboratories, LLC

Report File: CncSummary v1.09.rpt (04-24-13), WINH version 1.24 Printed On: 17-Dec-2013 15:13 

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

- Page 42 of 56 - Inhalation Report

Page 254 of 1107
PROJECT NO.:WIL-65501 PAGE 3

INHALTION TABLE 8

RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE

-----------------------------------------------------------------------------------------------------------------------------------

DAILY MEAN CONCENTRATION VALUES FOR 2-BROMO-3,3,3-TRIFLU (PPM)

RUN DATE 0 PPM 50 PPM 100 PPM 175 PPM

-----------------------------------------------------------------------------------------------------------------------------------

28-OCT-2013 0 49 95 174

0.0 2.6 3.7 8.1

NA 5.31 3.89 4.66

6 6 6 6

SD

CV

N

29-OCT-2013 0 47 96 167

0.0 1.9 8.9 8.7

NA 4.04 9.27 5.21

6 6 6 6

SD

CV

N

30-OCT-2013 0 49 100 182

0.0 3.2 9.2 6.9

NA 6.53 9.20 3.79

6 6 6 6

SD

CV

N

31-OCT-2013 0 52 106 176

0.0 4.2 5.6 10.9

NA 8.08 5.28 6.19

6 6 6 6

SD

CV

N

01-NOV-2013 0 52 106 174

0.0 2.9 5.0 5.3

NA 5.58 4.72 3.05

6 6 6 6

SD

CV

N

02-NOV-2013 0 51 105 184

0.0 2.1 4.9 8.8

NA 4.12 4.67 4.78

6 6 6 6

SD

CV

N

03-NOV-2013 0 47 96 167

0.0 3.5 4.8 10.3

NA 7.45 5.00 6.17

6 6 6 6

SD

CV

N

WIL Research Laboratories, LLC

Report File: CncSummary v1.09.rpt (04-24-13), WINH version 1.24 Printed On: 17-Dec-2013 15:13 

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

- Page 43 of 56 - Inhalation Report

Page 255 of 1107
PROJECT NO.:WIL-65501 PAGE 4

INHALTION TABLE 8

RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE

-----------------------------------------------------------------------------------------------------------------------------------

DAILY MEAN CONCENTRATION VALUES FOR 2-BROMO-3,3,3-TRIFLU (PPM)

RUN DATE 0 PPM 50 PPM 100 PPM 175 PPM

-----------------------------------------------------------------------------------------------------------------------------------

04-NOV-2013 0 49 105 163

0.0 2.1 4.0 6.7

NA 4.29 3.81 4.11

6 6 6 6

SD

CV

N

05-NOV-2013 0 53 103 183

0.0 5.0 9.9 14.3

NA 9.43 9.61 7.81

6 6 6 6

SD

CV

N

06-NOV-2013 0 55 104 184

0.0 2.4 7.3 9.6

NA 4.36 7.02 5.22

6 6 6 6

SD

CV

N

07-NOV-2013 0 50 100 171

0.0 5.6 11.4 17.9

NA 11.20 11.40 10.47

6 6 6 6

SD

CV

N

08-NOV-2013 0 45 94 173

0.0 4.9 7.1 7.6

NA 10.89 7.55 4.39

6 6 6 6

SD

CV

N

09-NOV-2013 0 56 98 191

0.0 2.0 3.2 5.0

NA 3.57 3.27 2.62

6 6 6 6

SD

CV

N

10-NOV-2013 0 52 106 155

0.0 4.9 2.6 64.9

NA 9.42 2.45 41.87

7 6 5 6

SD

CV

N

WIL Research Laboratories, LLC

Report File: CncSummary v1.09.rpt (04-24-13), WINH version 1.24 Printed On: 17-Dec-2013 15:13 

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

- Page 44 of 56 - Inhalation Report

Page 256 of 1107
PROJECT NO.:WIL-65501 PAGE 5

INHALTION TABLE 8

RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE

-----------------------------------------------------------------------------------------------------------------------------------

DAILY MEAN CONCENTRATION VALUES FOR 2-BROMO-3,3,3-TRIFLU (PPM)

RUN DATE 0 PPM 50 PPM 100 PPM 175 PPM

-----------------------------------------------------------------------------------------------------------------------------------

11-NOV-2013 0 47 96 172

0.0 3.1 6.0 11.9

NA 6.60 6.25 6.92

6 6 6 6

SD

CV

N

12-NOV-2013 0 46 93 163

0.0 5.6 13.0 24.2

NA 12.17 13.98 14.85

6 6 6 6

SD

CV

N

13-NOV-2013 0 49 97 173

0.0 2.0 6.1 10.8

NA 4.08 6.29 6.24

6 6 6 6

SD

CV

N

14-NOV-2013 0 50 98 177

0.0 4.5 9.4 19.5

NA 9.00 9.59 11.02

6 6 6 6

SD

CV

N

15-NOV-2013 0 54 106 184

0.0 1.2 4.2 4.1

NA 2.22 3.96 2.23

6 6 6 6

SD

CV

N

16-NOV-2013 0 48 103 173

0.0 5.5 9.3 15.8

NA 11.46 9.03 9.13

6 6 6 6

SD

CV

N

17-NOV-2013 0 54 108 187

0.0 1.6 2.7 3.3

NA 2.96 2.50 1.76

6 6 6 6

SD

CV

N

WIL Research Laboratories, LLC

Report File: CncSummary v1.09.rpt (04-24-13), WINH version 1.24 Printed On: 17-Dec-2013 15:13 

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

- Page 45 of 56 - Inhalation Report

Page 257 of 1107
PROJECT NO.:WIL-65501 PAGE 6

INHALTION TABLE 8

RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE

-----------------------------------------------------------------------------------------------------------------------------------

DAILY MEAN CONCENTRATION VALUES FOR 2-BROMO-3,3,3-TRIFLU (PPM)

RUN DATE 0 PPM 50 PPM 100 PPM 175 PPM

-----------------------------------------------------------------------------------------------------------------------------------

18-NOV-2013 0 54 107 182

0.0 1.3 2.9 5.2

NA 2.41 2.71 2.86

6 6 6 6

SD

CV

N

19-NOV-2013 0 47 107 162

0.0 2.1 12.5 12.2

NA 4.47 11.68 7.53

6 6 6 6

SD

CV

N

20-NOV-2013 0 44 96 153

0.0 4.2 13.4 18.9

NA 9.55 13.96 12.35

6 6 6 6

SD

CV

N

21-NOV-2013 NA 51 104 178

NA 3.4 4.7 15.4

NA 6.67 4.52 8.65

0 6 6 6

SD

CV

N

22-NOV-2013 NA NA 105 183

NA NA 4.8 8.6

NA NA 4.57 4.70

0 0 6 6

SD

CV

N

23-NOV-2013 NA NA NA 167

NA NA NA 8.0

NA NA NA 4.79

0 0 0 6

SD

CV

N

24-NOV-2013 NA NA NA 170

NA NA NA 16.6

NA NA NA 9.76

0 0 0 6

SD

CV

N

WIL Research Laboratories, LLC

Report File: CncSummary v1.09.rpt (04-24-13), WINH version 1.24 Printed On: 17-Dec-2013 15:13 

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

- Page 46 of 56 - Inhalation Report

Page 258 of 1107
PROJECT NO.:WIL-65501 PAGE 7

INHALTION TABLE 8

RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE

-----------------------------------------------------------------------------------------------------------------------------------

DAILY MEAN CONCENTRATION VALUES FOR 2-BROMO-3,3,3-TRIFLU (PPM)

RUN DATE 0 PPM 50 PPM 100 PPM 175 PPM

-----------------------------------------------------------------------------------------------------------------------------------

25-NOV-2013 NA NA NA 178

NA NA NA 6.0

NA NA NA 3.37

0 0 0 6

SD

CV

N

26-NOV-2013 NA NA NA 180

NA NA NA 12.3

NA NA NA 6.83

0 0 0 6

SD

CV

N

27-NOV-2013 NA NA NA 195

NA NA NA 30.5

NA NA NA 15.64

0 0 0 5

SD

CV

N

28-NOV-2013 NA NA NA 166

NA NA NA 11.9

NA NA NA 7.17

0 0 0 6

SD

CV

N

29-NOV-2013 NA NA NA 176

NA NA NA 16.2

NA NA NA 9.20

0 0 0 6

SD

CV

N

30-NOV-2013 NA NA NA 182

NA NA NA 20.9

NA NA NA 11.48

0 0 0 6

SD

CV

N

01-DEC-2013 NA NA NA 164

NA NA NA 18.4

NA NA NA 11.22

0 0 0 6

SD

CV

N

WIL Research Laboratories, LLC

Report File: CncSummary v1.09.rpt (04-24-13), WINH version 1.24 Printed On: 17-Dec-2013 15:13 

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

- Page 47 of 56 - Inhalation Report

Page 259 of 1107
PROJECT NO.:WIL-65501 PAGE 8

INHALTION TABLE 8

RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE

-----------------------------------------------------------------------------------------------------------------------------------

DAILY MEAN CONCENTRATION VALUES FOR 2-BROMO-3,3,3-TRIFLU (PPM)

RUN DATE 0 PPM 50 PPM 100 PPM 175 PPM

-----------------------------------------------------------------------------------------------------------------------------------

02-DEC-2013 NA NA NA 166

NA NA NA 12.3

NA NA NA 7.41

0 0 0 6

SD

CV

N

03-DEC-2013 NA NA NA 166

NA NA NA 14.1

NA NA NA 8.49

0 0 0 6

SD

CV

N

04-DEC-2013 NA NA NA 138

NA NA NA 19.8

NA NA NA 14.35

0 0 0 6

SD

CV

N

N:

SD:

CV (%):

0.0 3.2 4.8 10.7

38 39 40 52

NA 6.40 4.75 6.15

GRAND MEAN: 0 50 101 174

WIL Research Laboratories, LLC

Report File: CncSummary v1.09.rpt (04-24-13), WINH version 1.24 Printed On: 17-Dec-2013 15:13 

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

- Page 48 of 56 - Inhalation Report

Page 260 of 1107
 INHALATION TABLE 9

PROJECT NO.:WIL-65501I RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN TEST ATMOSPHERE CONCENTRATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GROUP: 0 PPM 10000 PPM

CHAMBER: 5A 5B

-----------------------------------------------------------------------------------------------------------------------------------

EXPOSURE ON 14-OCT-13

MEAN 0. 11046.

SD 0.0 1654.6

CV(%) 0.00 14.98

 N 5 2

EXPOSURE ON 15-OCT-13

MEAN 0. 9316.

SD 0.0 1437.5

CV(%) 0.00 15.43

 N 6 2

EXPOSURE ON 16-OCT-13

MEAN 0. 10272.

SD 0.0 1399.4

CV(%) 0.00 13.62

 N 5 2

EXPOSURE ON 17-OCT-13

MEAN 0. 9843.

SD 0.0 982.2

CV(%) 0.00 9.98

 N 5 2

EXPOSURE ON 18-OCT-13

MEAN 0. 10126.

SD 0.0 1388.8

CV(%) 0.00 13.71

 N 6 2

CV (%) = COEFFICIENT OF VARIATION

CONCENTRATION IN: PPM

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

- Page 49 of 56 - Inhalation Report

Page 261 of 1107
 INHALATION TABLE 9

PROJECT NO.:WIL-65501I RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN TEST ATMOSPHERE CONCENTRATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GROUP: 0 PPM 10000 PPM

CHAMBER: 5A 5B

-----------------------------------------------------------------------------------------------------------------------------------

EXPOSURE ON 19-OCT-13

MEAN 0. 9763.

SD 0.0 1517.5

CV(%) 0.00 15.54

 N 6 2

EXPOSURE ON 20-OCT-13

MEAN 0. 9792.

SD 0.0 1192.2

CV(%) 0.00 12.18

 N 6 2

EXPOSURE ON 21-OCT-13

MEAN 0. 10272.

SD 0.0 1349.9

CV(%) 0.00 13.14

 N 6 2

EXPOSURE ON 22-OCT-13

MEAN 0. 10887.

SD 0.0 1169.6

CV(%) 0.00 10.74

 N 6 2

EXPOSURE ON 23-OCT-13

MEAN 0. 9637.

SD 0.0 1453.8

CV(%) 0.00 15.09

 N 6 2

CV (%) = COEFFICIENT OF VARIATION

CONCENTRATION IN: PPM

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

- Page 50 of 56 - Inhalation Report

Page 262 of 1107
 INHALATION TABLE 9

PROJECT NO.:WIL-65501I RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN TEST ATMOSPHERE CONCENTRATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GROUP: 0 PPM 10000 PPM

CHAMBER: 5A 5B

-----------------------------------------------------------------------------------------------------------------------------------

EXPOSURE ON 24-OCT-13

MEAN 0. 10620.

SD 0.0 604.6

CV(%) 0.00 5.69

 N 5 2

EXPOSURE ON 25-OCT-13

MEAN 0. 9258.

SD 0.0 1195.7

CV(%) 0.00 12.92

 N 5 2

EXPOSURE ON 26-OCT-13

MEAN 0. 10821.

SD 0.0 1497.7

CV(%) 0.00 13.84

 N 6 2

EXPOSURE ON 27-OCT-13

MEAN 0. 10004.

SD 0.0 1554.9

CV(%) 0.00 15.54

 N 6 2

EXPOSURE ON 28-OCT-13

MEAN 0. 10602.

SD 0.0 918.5

CV(%) 0.00 8.66

 N 6 2

CV (%) = COEFFICIENT OF VARIATION

CONCENTRATION IN: PPM

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

- Page 51 of 56 - Inhalation Report

Page 263 of 1107
 INHALATION TABLE 9

PROJECT NO.:WIL-65501I RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN TEST ATMOSPHERE CONCENTRATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GROUP: 0 PPM 10000 PPM

CHAMBER: 5A 5B

-----------------------------------------------------------------------------------------------------------------------------------

EXPOSURE ON 29-OCT-13

MEAN 0. 9315.

SD 0.0 882.5

CV(%) 0.00 9.47

 N 6 2

EXPOSURE ON 30-OCT-13

MEAN 0. 10609.

SD 0.0 1139.1

CV(%) 0.00 10.74

 N 6 2

EXPOSURE ON 31-OCT-13

MEAN 0. 10579.

SD 0.0 1364.0

CV(%) 0.00 12.89

 N 6 2

EXPOSURE ON 01-NOV-13

MEAN 0. 10839.

SD 0.0 1433.3

CV(%) 0.00 13.22

 N 6 2

EXPOSURE ON 02-NOV-13

MEAN 0. 9936.

SD 0.0 978.6

CV(%) 0.00 9.85

 N 6 2

CV (%) = COEFFICIENT OF VARIATION

CONCENTRATION IN: PPM

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

- Page 52 of 56 - Inhalation Report

Page 264 of 1107
 INHALATION TABLE 9

PROJECT NO.:WIL-65501I RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN TEST ATMOSPHERE CONCENTRATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GROUP: 0 PPM 10000 PPM

CHAMBER: 5A 5B

-----------------------------------------------------------------------------------------------------------------------------------

EXPOSURE ON 03-NOV-13

MEAN 0. 11321.

SD 0.0 1626.3

CV(%) 0.00 14.37

 N 6 2

EXPOSURE ON 04-NOV-13

MEAN 0. 9710.

SD 0.0 1056.4

CV(%) 0.00 10.88

 N 5 2

EXPOSURE ON 05-NOV-13

MEAN 0. 10867.

SD 0.0 987.8

CV(%) 0.00 9.09

 N 6 2

EXPOSURE ON 06-NOV-13

MEAN 0. 10030.

SD 0.0 892.4

CV(%) 0.00 8.90

 N 6 2

EXPOSURE ON 07-NOV-13

MEAN 0. 9682.

SD 0.0 1084.0

CV(%) 0.00 11.20

 N 6 2

CV (%) = COEFFICIENT OF VARIATION

CONCENTRATION IN: PPM

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

- Page 53 of 56 - Inhalation Report

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 INHALATION TABLE 9

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SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN TEST ATMOSPHERE CONCENTRATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GROUP: 0 PPM 10000 PPM

CHAMBER: 5A 5B

-----------------------------------------------------------------------------------------------------------------------------------

EXPOSURE ON 08-NOV-13

MEAN 0. 10189.

SD 0.0 951.1

CV(%) 0.00 9.33

 N 6 2

EXPOSURE ON 09-NOV-13

MEAN 0. 9015.

SD 0.0 1420.6

CV(%) 0.00 15.76

 N 6 2

EXPOSURE ON 10-NOV-13

MEAN 0. 10376.

SD 0.0 1555.6

CV(%) 0.00 14.99

 N 6 2

EXPOSURE ON 11-NOV-13

MEAN 0. 9829.

SD 0.0 1076.9

CV(%) 0.00 10.96

 N 6 2

EXPOSURE ON 12-NOV-13

MEAN 0. 9969.

SD 0.0 520.4

CV(%) 0.00 5.22

 N 6 2

CV (%) = COEFFICIENT OF VARIATION

CONCENTRATION IN: PPM

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

- Page 54 of 56 - Inhalation Report

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 INHALATION TABLE 9

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SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN TEST ATMOSPHERE CONCENTRATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GROUP: 0 PPM 10000 PPM

CHAMBER: 5A 5B

-----------------------------------------------------------------------------------------------------------------------------------

EXPOSURE ON 13-NOV-13

MEAN 0. 10522.

SD 0.0 606.7

CV(%) 0.00 5.77

 N 6 2

EXPOSURE ON 14-NOV-13

MEAN 0. 9773.

SD 0.0 493.6

CV(%) 0.00 5.05

 N 6 2

EXPOSURE ON 15-NOV-13

MEAN 0. 9373.

SD 0.0 751.7

CV(%) 0.00 8.02

 N 6 2

EXPOSURE ON 16-NOV-13

MEAN 0. 8667.

SD 0.0 533.2

CV(%) 0.00 6.15

 N 6 2

EXPOSURE ON 17-NOV-13

MEAN 0. 10580.

SD 0.0 686.6

CV(%) 0.00 6.49

 N 6 2

CV (%) = COEFFICIENT OF VARIATION

CONCENTRATION IN: PPM

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

- Page 55 of 56 - Inhalation Report

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 INHALATION TABLE 9

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SPONSOR:AMERICAN PACIFIC CORP. DAILY MEAN TEST ATMOSPHERE CONCENTRATIONS

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GROUP: 0 PPM 10000 PPM

CHAMBER: 5A 5B

-----------------------------------------------------------------------------------------------------------------------------------

EXPOSURE ON 18-NOV-13

MEAN 0. 10285.

SD 0.0 610.9

CV(%) 0.00 5.94

 N 6 2

EXPOSURE ON 19-NOV-13

MEAN 0. 9867.

SD 0.0 516.9

CV(%) 0.00 5.24

 N 6 2

EXPOSURE ON 20-NOV-13

MEAN 0. 9305.

SD 0.0 947.5

CV(%) 0.00 10.18

 N 6 2

ALL STUDY DAYS COMBINED

MEAN 0. 10076.

SD 0.0 607.9

CV(%) 0.00 6.03

 N 38 38

-----------------------------------------------------------------------------------------------------------------------------------

CV (%) = COEFFICIENT OF VARIATION

CONCENTRATION IN: PPM

 PCHCSUv4.06

 01/27/2014

 R:01/27/2014

WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

- Page 56 of 56 - Inhalation Report

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American Pacific Corporation

APPENDIX D

Animal Room Environmental Conditions

 Page 269 of 1107
TEST SYSTEM:

DATE IN TIME IN

DATE OUT TIME OUT

09/26/13 08:00

12/05/13 18:00

RAT HIGH HUMIDITY %RH:

ROOM SPECIFICATIONS: 66.0 76.0 30.0 LOW TEMPERATURE °F: HIGH TEMPERATURE °F: LOW HUMIDITY %RH:

70.0

STUDY SPECIFICATIONS:

LOW TEMPERATURE °C: 18.9 24.4 HIGH TEMPERATURE °C:

65501

B ROOM 38

DATE

PRIMARY TEMP SECONDARY TEMP PRIMARY HUM SECONDARY HUM

MEAN (°F) MEAN (°C) MEAN (°F) MEAN (°C) MEAN (%RH) MEAN (%RH)

09/26/13 71.5 21.9 22.2 71.9 45.8 44.7

09/27/13 70.8 21.6 21.9 71.5 45.1 44.3

09/28/13 70.9 21.6 22.0 71.6 45.3 44.5

09/29/13 70.9 21.6 22.1 71.7 46.9 46.3

09/30/13 70.8 21.6 21.9 71.5 47.5 46.9

10/01/13 71.2 21.8 22.1 71.8 46.6 46.0

10/02/13 71.0 21.7 21.9 71.5 48.4 47.7

10/03/13 71.4 21.9 22.2 71.9 48.1 47.6

10/04/13 71.1 21.7 21.9 71.5 49.2 48.6

10/05/13 70.9 21.6 21.9 71.5 50.2 49.7

10/06/13 71.0 21.7 21.9 71.5 49.6 49.0

10/07/13 71.0 21.7 22.1 71.7 44.7 44.2

10/08/13 70.5 21.4 21.8 71.3 43.9 43.2

10/09/13 70.9 21.6 22.0 71.6 43.4 42.6

10/10/13 70.9 21.6 22.0 71.6 42.6 41.8

10/11/13 70.9 21.6 21.9 71.5 44.5 43.6

10/12/13 71.2 21.8 22.1 71.7 45.2 44.5

10/13/13 70.9 21.6 21.9 71.5 46.7 46.2

10/14/13 71.5 21.9 22.3 72.1 45.9 45.1

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DATE

PRIMARY TEMP SECONDARY TEMP PRIMARY HUM SECONDARY HUM

MEAN (°F) MEAN (°C) MEAN (°F) MEAN (°C) MEAN (%RH) MEAN (%RH)

10/15/13 70.7 21.5 21.9 71.5 47.1 46.4

10/16/13 71.3 21.8 22.2 71.9 48.6 48.1

10/17/13 70.6 21.4 21.9 71.5 46.0 45.3

10/18/13 70.4 21.3 21.7 71.1 45.4 44.4

10/19/13 71.0 21.7 22.1 71.8 43.8 43.2

10/20/13 71.3 21.8 22.3 72.1 42.8 42.1

10/21/13 70.9 21.6 21.9 71.5 45.6 44.6

10/22/13 71.0 21.7 22.1 71.7 42.5 41.7

10/23/13 70.8 21.6 22.1 71.7 42.6 42.0

10/24/13 70.8 21.6 22.1 71.8 42.5 41.8

10/25/13 72.5 22.5 22.9 73.3 40.6 40.3

10/26/13 71.1 21.7 22.3 72.1 42.0 41.3

10/27/13 71.2 21.8 22.3 72.1 42.2 41.6

10/28/13 70.3 21.3 21.7 71.1 43.3 42.4

10/29/13 70.6 21.4 21.8 71.3 43.2 42.3

10/30/13 70.8 21.6 21.8 71.3 47.3 46.1

10/31/13 71.6 22.0 22.3 72.1 49.2 48.4

11/01/13 70.4 21.3 21.8 71.2 46.4 45.5

11/02/13 70.9 21.6 22.1 71.7 44.4 43.8

11/03/13 70.9 21.6 22.1 71.7 44.3 43.4

11/04/13 71.0 21.7 22.1 71.7 43.4 42.5

11/05/13 70.9 21.6 22.0 71.6 43.9 43.1

11/06/13 71.0 21.7 21.9 71.5 46.2 45.2

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DATE

PRIMARY TEMP SECONDARY TEMP PRIMARY HUM SECONDARY HUM

MEAN (°F) MEAN (°C) MEAN (°F) MEAN (°C) MEAN (%RH) MEAN (%RH)

11/07/13 71.0 21.7 22.1 71.7 43.9 42.9

11/08/13 70.9 21.6 22.1 71.7 43.1 42.2

11/09/13 71.9 22.2 22.5 72.5 41.9 41.2

11/10/13 72.1 22.3 22.6 72.7 41.4 41.0

11/11/13 70.6 21.4 21.9 71.4 42.6 41.8

11/12/13 71.2 21.8 22.2 72.0 41.2 40.6

11/13/13 70.8 21.6 22.0 71.6 42.3 41.6

11/14/13 71.6 22.0 22.4 72.3 41.6 40.9

11/15/13 71.6 22.0 22.3 72.2 42.0 41.1

11/16/13 71.6 22.0 22.3 72.2 44.4 43.6

11/17/13 71.5 21.9 22.2 72.0 48.5 47.8

11/18/13 71.2 21.8 22.2 72.0 42.5 41.9

11/19/13 71.0 21.7 22.1 71.8 42.0 41.3

11/20/13 70.8 21.6 22.0 71.6 42.0 41.0

11/21/13 71.2 21.8 22.1 71.8 42.4 41.6

11/22/13 70.8 21.6 21.9 71.4 43.5 42.8

11/23/13 70.9 21.6 22.1 71.7 41.2 40.3

11/24/13 71.5 21.9 22.4 72.4 39.8 39.1

11/25/13 70.6 21.4 21.9 71.5 40.8 39.9

11/26/13 70.8 21.6 22.1 71.8 40.1 39.5

11/27/13 70.7 21.5 22.1 71.8 39.8 39.3

11/28/13 70.7 21.5 22.1 71.8 39.5 38.9

11/29/13 70.8 21.6 22.1 71.8 39.3 38.6

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DATE

PRIMARY TEMP SECONDARY TEMP PRIMARY HUM SECONDARY HUM

MEAN (°F) MEAN (°C) MEAN (°F) MEAN (°C) MEAN (%RH) MEAN (%RH)

11/30/13 71.1 21.7 22.2 72.0 39.3 38.7

12/01/13 70.9 21.6 22.2 71.9 39.7 39.1

12/02/13 70.9 21.6 22.2 71.9 40.2 39.5

12/03/13 70.8 21.6 22.1 71.7 40.8 40.2

12/04/13 70.8 21.6 21.9 71.4 43.4 42.7

12/05/13 72.1 22.3 22.5 72.5 45.9 45.2

SUMMARY OF DAILY MEANS

71.0 70.3 72.5

MEAN MIN MAX

PRIMARY TEMP °F:

PRIMARY TEMP °C:

PRIMARY HUM %RH:

N DAYS

21.7 21.3 22.5

43.2 38.6 49.7

71.8

71

SECONDARY TEMP °F: 71.1 73.3

SECONDARY TEMP °C:

SECONDARY HUM %RH:

22.1 21.7 22.9

43.9 39.3 50.2

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Page 273 of 1107
N DAYS

LAST DAY

FIRST DAY

MEAN

N SAMPLES

SD

MAX

MIN

B ROOM 38 SUMMARY OF HOURLY VALUES

71.0 43.2

64.1

76.3

1689

34.4

63.1

1689

1.82 3.91

PRIMARY TEMP PRIMARY HUM

09/26/13

12/05/13

71

71.8

66.5

76.2

1689

1.67

43.9

34.7

64.5

1689

4.20

°F

°F

°F

°F

°F

°F

SECONDARY TEMP SECONDARY HUM

%RH

%RH

%RH

%RH

%RH

%RH

SE 0.04 0.04 0.10 0.10

21.7

17.8

24.6

1.01

°C

°C

°C

0.02

22.1

19.2

24.6

0.93

°C

°C

°C

0.02

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PROJECT NO.:WIL- TEMPERATURE/HUMIDITY - STUDY SUMMARY REPORT

SPONSOR:

Page 274 of 1107
STUDY 65501 SUMMARY OF HOURLY VALUES

PRIMARY TEMP

LAST DAY

FIRST DAY

MEAN

N SAMPLES

SD

MAX

MIN

71.0 43.2

64.1

76.3

1689

34.4

63.1

1689

1.82 3.91

°F

PRIMARY HUM

09/26/13

12/05/13

71

71.8

66.5

76.2

1689

1.67

43.9

34.7

64.5

1689

4.20

°F

°F

°F

°F

°F

N DAYS

SECONDARY TEMP SECONDARY HUM

%RH

%RH

%RH

%RH

%RH

%RH

SE 0.04 0.04 0.10 0.10

21.7

17.8

24.6

1.01

°C

°C

°C

0.02

°C

22.1

19.2

24.6

0.93

°C

°C

0.02

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SPONSOR:

09:28 24-Jan-14 WIL METASYS VERSION 2.27

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American Pacific Corporation

APPENDIX E

Pathology Report (WIL Research)

 Page 276 of 1107
WIL-65501 2-Bromo-3,3,3-Trifluoropropene 

American Pacific Corporation 

-1- 

An Inhalation Reproduction/Developmental 

Toxicity Screening Study of 2-Bromo-3,3,3-Trifluoropropene in Rats 

Pathology Report 

WIL Research Pathology Department 

 Page 277 of 1107
WIL-65501 2-Bromo-3,3,3-Trifluoropropene 

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TABLE OF CONTENTS

Page

 Table of Contents .......................................................................................2

 1. Introduction ................................................................................................3

 2. Study Design ...............................................................................................3

 3. Methods .......................................................................................................4

 3.1. Anatomic Pathology.....................................................................................4

 3.1.1. Macroscopic Examination ...........................................................................4

 3.1.2. Organ Weights .............................................................................................5

 3.1.3. Microscopic Examination ............................................................................5

 3.2. Data Interpretation .......................................................................................7

 4. Results .........................................................................................................8

 4.1. Survival ........................................................................................................8

 4.2. Gross Observations ......................................................................................8

 4.3. Organ Weights .............................................................................................8

 4.4. Histologic Changes ......................................................................................9

 5. Conclusions .................................................................................................9

 6. References .................................................................................................10

 7. Report Submission ...................................................................................11

 Page 278 of 1107
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1. INTRODUCTION

The objective of this study was to provide preliminary information on the potential 

adverse effects of the test substance on male and female reproduction within the scope of 

a screening study. This encompassed gonadal function, mating behavior, conception, 

parturition, and lactation of the F0 generation and the development of offspring from 

conception through day 4 of postnatal life. This pathology report addresses the 

anatomical pathology endpoints of the study. 

2. STUDY DESIGN

Male and female Crl:CD(SD) rats were administered filtered air or 2-Bromo-3,3,3-

Trifluoropropene atmospheres as a daily 6-hour whole-body inhalation exposure for 

animals in Groups 1, 2, 3, and 4, as indicated in the following table. 2-Bromo-3,3,3-

Trifluoropropene atmospheres were administered as a daily 5-minute whole-body 

exposure for animals in Group 5. 

F0 males, 71-85 days of age at initiation of dosing, were exposed for a minimum of 

14 days prior to mating and continuing until the day prior to the scheduled euthanasia. 

The total exposure period for the F0 males encompassed 28-29 consecutive days. 

F0 females, 61-75 days at the start of estrous cycle determination, were exposed for a 

minimum of 14 days prior to mating and continuing throughout mating until gestation 

day 20, inclusively. F0 females that did not deliver were exposed until 1 day prior to 

scheduled euthanasia on post-mating or post-cohabitation day 25. 

Group 

Number Treatment 

Exposure Level 

(ppm) 

Number of Animals 

Males Females 

1 Filtered Air 0 12 12 

2 2-Bromo-3,3,3-Trifluoropropene 50 12 12 

3 2-Bromo-3,3,3-Trifluoropropene 100 12 12 

4 2-Bromo-3,3,3-Trifluoropropene 175 12 12 

5 2-Bromo-3,3,3-Trifluoropropene 10,000 12 12 

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3. METHODS

3.1. ANATOMIC PATHOLOGY

3.1.1. MACROSCOPIC EXAMINATION

Complete postmortem examinations were performed on all animals euthanized at the 

scheduled necropsy. Animals were euthanized by carbon dioxide inhalation and 

exsanguinated. For F0 females, the numbers of former implantation sites and corpora 

lutea were recorded. At the time of necropsy, the following tissues and organs were 

collected and placed in 10% neutral-buffered formalin fixative unless otherwise noted: 

Brain 

Coagulating glands 

Kidneys 

Liver (sections of 2 lobes) 

Lungs 

Mammary glands (females only) 

Ovariesa and oviduct (2) 

Pituitary gland 

Prostate gland 

Seminal vesicles (2) 

Spleen 

Testes with epididymides (2)b

 and vas deferens 

Uterusc with cervix and vagina 

All gross lesionsd

a

 - Ovaries were fixed in 10% neutral-buffered formalin for approximately 48 hours 

following which all ovaries were transferred to 70% ethanol. 

b

 - Testis (right) and epididymis (right and remainder of left) were fixed in modified 

Davidson’s solution; care was taken to ensure separation between the left and right 

organs. c

 - Any uterus stained in 10% ammonium solution for detection of implantation sites was 

discarded and not preserved in 10% neutral buffered formalin. 

d

 - Representative sections of corresponding organs from a sufficient number of controls 

were retained for comparison, if possible. 

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3.1.2. ORGAN WEIGHTS

The following organs were weighed from all F0 animals at the scheduled necropsies: 

Brain 

Epididymides (total and caudal)* 

Kidneys 

Liver 

Lungs 

Ovaries (without oviducts) 

Pituitary gland 

Spleen 

Testes* 

Paired organs were weighed together. Designated (*) paired organs were weighed 

separately. Organ to final body weight and organ to brain weight ratios were calculated. 

3.1.3. MICROSCOPIC EXAMINATION

Microscopic examination of routinely prepared hematoxylin-eosin stained paraffin 

sections was performed on the following tissues collected at necropsy from all F0 parental 

animals from the control, 175, and 10,000 ppm groups. Sections of the testes and 

epididymides were also stained with Periodic Acid Schiff’s stain (PAS) and hematoxylin. 

Gross lesions were examined from all animals and correlated to microscopic findings if 

possible. 

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Cervix 

Coagulating gland 

Epididymidesa,b 

Lungs 

Mammary glands (female only) 

Ovariesc

Pituitary gland 

Prostate gland 

Seminal vesicles 

Spleen 

Testesa,b

Uterus 

Vagina 

Vas deferens 

All gross (internal) lesions 

a

 - Sections of 2-4 microns of the testis (transverse) and epididymis (longitudinal) were 

stained in PAS and hematoxylin in addition to routine hematoxylin and eosin 

staining. 

b - If the left testis or epididymis was noted with a gross lesion, the left testis and 

epididymis were fixed in modified Davidson’s solution and the right testis and 

epididymis were homogenized. c - All ovaries were paraffin embedded. Five (5) sections were taken approximately 

100 μm apart from the inner middle of each ovary from all the F0 females in the 

control, 175, and 10,000 ppm groups at scheduled termination and for any females 

suspected of reduced fertility. In addition, a single section was taken for a 

qualitative bilateral evaluation of each ovary. A quantitative histopathologic 

evaluation of multiple sections was conducted. This examination included 

enumeration of the total number of primordial follicles according to the methods of 

Bolon et al., (1997), Bucci et al., (1997), and Picut et al., (2008). 

Stained histologic sections were examined by light microscopy and observations were 

entered in the WIL Toxicology Data Management System (WTDMSTM) by the 

pathologist. Histologic sections were of adequate size and quality for detailed evaluation, 

and the number of tissues examined from each treatment group was sufficient to allow 

detection of test substance-related histologic alterations. 

Severity grades were assigned to non-neoplastic histopathologic diagnoses in compliance 

with the following general guidelines, as presented in the following table. Severity 

grades were assigned based on the severity of alterations in the examined histologic 

sections and may not reflect the overall severity of the pathologic process in the entire 

tissue, organ, or animal. The WTDMSTM histopathology tables contain all of the 

recorded data and serve as the basis for this narrative report.

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Unremarkable Tissue considered to be within normal limits, under the conditions 

of the study and considering the age, sex, and strain of the animal 

concerned. 

Present A non-gradable histologic change for which no additional 

information would be gained by assigning a severity grade 

(e.g. cyst). 

Grade 1 

(Minimal) 

 A histologic change that barely exceeds that which is considered 

to be within normal limits. This change is unlikely to produce any 

functional impairment. 

Grade 2 

(Mild) 

 A histologic change that is easily identified but of limited severity. 

This change probably does not produce any functional 

impairment. 

Grade 3 

(Moderate) 

 A histologic change that is a prominent feature of the tissue but 

not of maximal severity. Limited tissue or organ dysfunction is 

possible. 

Grade 4 

(Severe) 

 A histologic change that is an overwhelming feature of the tissue 

and that may cause significant tissue or organ dysfunction. 

3.2. DATA INTERPRETATION

In the discussion of organ weights and mean number of ovarian primordial follicles, the 

indication of higher or lower mean values refers to a statistically significant [p<0.05 or 

p<0.01 using Dunnett’s test (Dunnett, 1964)] difference between test substance-treated 

versus control group animals in the present study. In addition, historical control values 

for this laboratory were consulted to refine data interpretation. The discussion of 

individual parameters below refers to group mean values unless stated otherwise 

The WIL Research historical control database, version 3.3, for Cr1:CD(SD) rats, 

7-50 weeks of age male and female organ weights, was consulted and referenced as 

necessary for the interpretation of data. 

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4. RESULTS

4.1. SURVIVAL

There was no test substance-related effect on survival. All animals survived until 

scheduled sacrifice. 

4.2. GROSS OBSERVATIONS

Review of the gross necropsy observations revealed no observations that were considered 

to be associated with administration of the test substance. 

4.3. ORGAN WEIGHTS

There was a test substance-related lower (7.1%, p<0.05) final body weight in the 

10,000 ppm group males. There were no test substance-related alterations in organ 

weights. 

Some organ weight differences were statistically significant when compared to the 

control group but were considered to be a result of a test substance-related effect on final 

body weight. There was a significantly (p<0.01) higher left epididymis weight relative to 

final body weight in the 10,000 ppm group males. Since the change did not correlate to 

histologic findings and the mean absolute weight was not affected, the change was 

considered to be due to the lower mean final body weight. There was a significantly 

(p<0.01) higher right testis weight relative to body weight in the 10,000 ppm group 

males. This change was also a result of a low mean final body weight in this dose group, 

and was not test substance-related. 

Some statistically significant differences were observed when the control and test 

substance-treated groups were compared, but the changes were not considered test 

substance-related. There was a significantly (p<0.01) higher mean lung weight relative to 

body weight and a significantly (p<0.01) higher mean lung weight relative to brain 

weight in the 175 ppm group males compared to the control group. Because the mean 

absolute lung weight was not affected, the relative weights were within the WIL 

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WIL-65501 2-Bromo-3,3,3-Trifluoropropene 

American Pacific Corporation 

-9- 

Research historical control data ranges, and there were no histopathologic correlates, the 

changes in relative weights were not considered toxicologically significant. There were 

significantly (p<0.05 or p<0.01) lower pituitary weights (absolute and relative) in 100, 

175, and/or 10,000 ppm group males and females; however, because the changes did not 

follow a dose-response profile, were within the WIL Research historical control range, 

and did not correlate to histologic findings at 175 or 10,000 ppm, the statistically 

significant changes were considered spurious. 

4.4. HISTOLOGIC CHANGES

There were no test substance-related microscopic findings. All histologic changes were 

considered to be incidental findings or related to some aspect of experimental 

manipulation other than administration of the test substance. There was no test 

substance-related alteration in the prevalence, severity, or histologic character of those 

incidental tissue alterations. 

There was no apparent test substance-related effect on the counts of primordial and 

primary follicles from ovaries in the control, 175, and 10,000 ppm group females. 

5. CONCLUSIONS

Whole body exposure of 2-Bromo-3,3,3-Trifluoropropene atmospheres to male and 

female Crl:CD(SD) rats as a daily 6-hour whole-body inhalation exposure (at 50, 100, or 

175 ppm) or as a daily 5-minute whole-body exposure (at 10,000 ppm) was associated 

with a slightly lower mean final body weight in 10,000 ppm males. There were no test 

substance-related effects on survival and there were no test substance-related gross 

pathologic changes, microscopic changes, or organ weight effects. There was no test 

substance-related effect on primordial/primary follicle counts. 

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6. REFERENCES

 Bolon, B.; Bucci, T.J.; Warbritton, A.R.; Chen, J.J.; Mattison D.R.; Heindel; J.J. 

Differential follicle counts as a screen for chemically induced ovarian toxicity in 

mice: Results from continuous breeding bioassays. Fundamentals of Applied 

Toxicology 1997, 39, 1-10. 

 Bucci, T.J.; Bolon, B.; Warbritton, A.R.; Chen, J.J.; Heindel, J.J. Influence of 

sampling on the reproducibility of ovarian follicle counts in mouse toxicity studies. 

Reproductive Toxicology 1997, 13(5), 689-696. 

 Dunnett, C.W. New tables for multiple comparisons with a control. Biometrics

1964, 20, 482-491. 

 Picut, C.A.; Swanson, C.L.; Scully, K.L.; Roseman, V.C.; Parker, R.F.; 

Remick, A.K. Ovarian follicle counts using proliferating cell nuclear antigen 

(PCNA) and semi-automated image analysis in rats. Toxicologic Pathology 2008,

36(5), 674-679.

 Page 286 of 1107
WIL-65501 

American Pacific Corporation 

WIL-65501 Pathology Report 

1 Report Submitted By: 

Catherine A. Picut, VMD, DACVP, DABT Date 

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WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

APPENDIX F

WIL Research Reproductive Historical Control Data [Crl:CD(SD) Rats]

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Range of Study Dates:

Number of Studies/Data Sets:

Study Type: 10/00 05/11 -

/

Strain:

Male/Female Rat

1-/2-Gen Crl:CD(SD)

Historical Control Summary of Reproductive Performance

Total Mean S.D. N Mean -/+ 2 S.D. Mean -/+ 3 S.D. Min/Max Value

35 65

Male Copulation Index (%)

Male Mating Index (%) 95.5 4.05 87.40 83.35 63 // / 86.7 100.0

Male Fertility Index (%) 87.5 7.30 72.90 65.60 63 70.0 100.0

92.4 6.72 78.96 72.24 49 70.0 100.0

/

/

/

/

/

/

Number of Males in Control Group

Number that did not Deliver

Number of Females Selected to Deliver

Number that Delivered

Number with Dystocia

Number with Total Litter Loss

96.3 3.80 88.70 84.90 65 86.7 100.0

88.0 7.25 73.50 66.25 65 / 70.0 100.0

/

/

/

/

/

Female Conception Index (%) 92.3 6.73 78.84 72.11 48 // / 70.0 100.0

Female Mating Index (%)

Female Fertility Index (%)

Number of Females in Control Group

1837

1903

1868

1624

225

14

2

100.00 100.00

100.00

100.00

100.00

100.00

100.00

100.00

100.00 100.00

100.00

100.00

Number that Died Prior to Delivery 7

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/

Strain:

Female Rat

1-/2-Gen Crl:CD(SD)

Historical Control Summary of Reproductive Performance

Mean S.D. N Mean -/+ 2 S.D. Mean -/+ 3 S.D. Min/Max Value

35 65

Mean No. of Former Implantation Sites at Weaning 14.7 58 0.78

Mean No. of Sites Unaccounted for at Weaning 0.8 56 0.26

12.6 16.0

0.3 1.4 /

/

Mean Estrous Cycle Length (days) 4.5 0.39 65 4.0 5.8

3.0 0.50 65 1.8 4.7

/

/

/

Mean Viable Litter Size (PND 0)

Mean Gestation Length (days)

Mean Pre-Coital Interval (days)

Mean Number of Pups Born

Mean % Females/ Litter

Mean % Males/ Litter

22.0 0.16 65 21.5 22.3

13.8 0.81 65 11.7 15.1 /

/

13.6 0.82 65 11.6 15.0

50.4 2.78 65 44.2 57.3 /

/

49.7 2.65 65 43.4 55.8 /

Mean Post-Implantation Loss (%/Litter) 6.2 2 3.46 3.8 8.7 /

/

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

2.00

21.68

12.18

11.96

44.84

44.40

13.14

0.28

0.00

3.72

4.00

22.32

15.42

15.24

55.96

55.00

16.26

1.32

13.12

5.28

1.50

21.52

11.37

11.14

42.06

41.75

12.36

0.02

0.00

3.33

4.50

22.48

16.23

16.06

58.74

57.65

17.04

1.58

16.58

5.67

Mean Primordial Follicle Count of 10 Sections/Dam 121.7 30 36.37 50.4 184.4 48.96 / 194.44 12.59 / 230.81 /

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Range of Study Dates:

Number of Studies/Data Sets:

Study Type: 10/00 05/11 -

/

Age Range:

Strain:

0 - 21 Days

Male/Female Rat

1-/2-Gen Crl:CD(SD)

Historical Control Summary of Pup Survival Indices (%)

Mean S.D. N Mean -/+ 2 S.D. Mean -/+ 3 S.D. Min/Max Value

35 65

PND 0 (Relative to No. Born) / /

PND 0 to PND 1 / /

PND 1 to PND 4 (Before Selection) / /

PND 4 (After Selection) to PND 7 / /

PND 7 to PND 14 / /

PND 14 to PND 21 / /

Birth to PND 4 (Before Selection) / /

PND 4 (After Selection) to PND 21 / /

Mean Number of Pups Born

Survival (%)

98.0 60 1.95

98.0 65 1.34

98.7 65 1.25

98.4 65 1.93

98.9 65 1.29

99.4 65 1.18

99.6 65 0.92

95.3 65 2.63

96.20

94.54

96.32

97.04

97.76

90.04

94.10

95.32

94.95

92.61

95.03

95.86

96.84

87.41

92.15

93.98

91.1 100.0 /

93.3 100.0

94.6 100.0 /

/

87.0 99.8

93.5 100.0 /

/

93.5 100.0

94.7 100.0 /

/

83.8 98.7 /

13.8 65 0.81 12.18 11.37 11.7 15.1 / / 15.42 16.23 /

100.00

100.00

100.00

100.00

100.00

100.00

100.00

100.00

100.00

100.00

100.00

100.00

100.00

100.00

100.00

100.00

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Range of Study Dates:

Number of Studies/Data Sets:

Study Type: 10/00 05/11 -

/

Age Range:

Strain:

1 - 28 Days

Male/Female Rat

1-/2-Gen Crl:CD(SD)

Historical Control Summary of Pup Body Weights (g)

35 65

PND 7

PND 14

PND 21

PND 4

Males (g) PND

Females (g) PND

Mean S.D. N Mean -/+ 2 S.D. Mean -/+ 3 S.D. Min/Max Value

Mean S.D. N Mean -/+ 2 S.D. Mean -/+ 3 S.D. Min/Max Value

9.5 65 0.48

14.6 65 1.14

8.5 10.4

11.3 16.7 /

/

10.0 0.49 65 9.1 11.0 /

15.4 1.20 65 11.9 17.6

30.9 3.28 63 20.2 36.4 /

/

48.6 4.98 65 32.8 57.8

79.3 4.93 8 72.0 88.4 /

/

73.4 8 4.58 66.7 82.4 /

29.7 63 3.10 20.3 34.8 /

46.5 65 4.55 32.8 54.9 /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

9.02

13.00

24.34

38.64

69.44

8.54

12.32

23.50

37.40

64.24

10.98

17.80

37.46

58.56

89.16

10.46

16.88

35.90

55.60

82.56

8.53

11.80

21.06

33.66

64.51

8.06

11.18

20.40

32.85

59.66

11.47

19.00

40.74

63.54

94.09

10.94

18.02

39.00

60.15

87.14

PND 7

PND 14

PND 21

PND 4

PND 11 23.1 1.88 3 19.34 26.86 17.46 28.74 / / 22.0 25.3 /

PND 17 32.2 0.49 2 31.22 33.18 30.73 33.67 / / 31.9 32.6 /

PND 11 22.1 3 2.02 18.06 26.14 16.04 28.16 / / 20.9 24.4 /

PND 17 30.9 2 0.64 29.62 32.18 28.98 32.82 / / 30.5 31.4 /

PND 1 7.1 0.23 65 6.64 7.56 6.41 7.79 / / / 6.7 7.6

PND 1 6.7 0.22 65 6.26 7.14 6.04 7.36 / / 6.4 7.1 /

PND 28

PND 28

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Range of Study Dates:

Number of Studies/Number Data Sets:

Study Type: 10/00 05/11 -

/

Age:

Strain:

21 Days

Male/Female Rat

Crl:CD(SD) 1-/2-Gen

Historical Control Summary of Pup Organ Weights (PND 21)

35 65

Mean S.D. N Mean -/+ 2 S.D. Min/Max Value

Brain (g)

Thymus (g)

Spleen (g)

Mean -/+ 3 S.D.

Males

Females

Brain (g)

Thymus (g)

Spleen (g)

1.4556 0.04067 50 1.3451 1.5436

0.2210 0.04129 50 0.1471 0.3641

/

/

/

0.2061 0.03452 50 0.1617 0.3541

1.4063 0.03764 50 1.3142 1.5082 /

/

0.2161 0.03828 50 0.1401 0.3099

0.2079 0.03517 50 0.1669 0.3483 /

/

/

/ /

/ /

/ /

/ /

/ /

0.13842

0.13706

1.33102

0.13954

0.13756

1.37426

0.30358

0.27514

1.48158

0.29266

0.27824

1.53694

0.09713

0.10254

1.29338

0.10126

0.10239

1.33359

0.34487

0.30966

1.51922

0.33094

0.31341

1.57761

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Sex: Species:

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Range of Study Dates:

Number of Studies/Control Groups:

Study Type: 10/00 05/11 -

/

Strain:

Male/Female Rat

1-/2-Gen Crl:CD(SD)

Historical Control Summary of Developmental Landmarks

Mean S.D. N Mean -/+ 2 S.D. Mean -/+ 3 S.D. Min/Max Value

35 65

Mean Body Weight at Aquisition (g)

Mean Female Anogenital Distance (PND1) (mm)

Mean Male Anogenital Distance (PND1) (mm)

Mean Day of Balanopreputial Separation

Mean Body Weight at Aquisition (g)

Mean Day of Vaginal Patency

4.23 0.364 12 3.5 4.7

2.30 0.218 12 1.8 2.6

/

/

/

45.3 1.29 31 43.0 49.0

229.9 12.85 31 203.7 251.7 /

/

33.6 1.17 31 31.3 37.0

111.6 5.26 31 100.0 123.2 /

/

/

/ /

/ /

/ /

/ /

/ /

1.864

42.72

204.20

31.26

101.08

3.502

2.736

47.88

255.60

35.94

122.12

4.958

1.646

41.43

191.35

30.09

95.82

3.138

2.954

49.17

268.45

37.11

127.38

5.322

Males

Females

Males

Mean Day of Pinnal Detachment

Males

Mean Day of Eye Opening

Mean Day of Surface Righting Response

Females

Females

Males

Mean Day of Hair Growth

Females

Mean Day of Incisor Eruption

Males

Females

5.1 2 0.07

4.1 6 0.12

13.6 4 1.51

10.3 6 0.78

5.1 5.2

4.0 4.3 /

/

11.8 15.2

9.3 11.4 /

/

5.0 0.07 2 5.0 5.1 /

15.9 6 1.13 15.1 17.8 /

4.0 6 0.08 4.0 4.2 /

16.0 6 1.05 15.1 17.8 /

13.5 4 1.43 11.7 15.0 /

10.2 6 0.70 9.3 11.1 /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

4.86

4.96

3.86

3.84

13.90

13.64

10.64

10.58

8.74

8.80

5.14

5.24

4.34

4.16

18.10

18.16

16.36

16.62

11.86

11.60

4.79

4.89

3.74

3.76

12.85

12.51

9.21

9.07

7.96

8.10

5.21

5.31

4.46

4.24

19.15

19.29

17.79

18.13

12.64

12.30

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Sex: Species:

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Range of Study Dates:

Number of Studies/Number Data Sets:

Study Type: 10/00 05/11 -

/

Strain:

Male/Female Rat

1-/2-Gen Crl:CD(SD)

Historical Control Summary of Male and Female Organ Weights (Necropsy)

35 65

Mean S.D. N Mean -/+ 2 S.D. Min/Max Value

Mean Seminal Vesicle/Coagulating Gland Weight (g)

Mean Right Testis Weight (g)

Mean Prostate Weight (g)

Mean -/+ 3 S.D.

Mean Left Testis Weight (g)

Mean Left Epididymis Weight (g)

Mean Right Epididymis Weight (g)

Mean Left Cauda Epididymis Weight (g)

Mean Right Cauda Epididymis Weight (g)

Males

Females

Mean Combined Ovary/Oviduct Weight (g)

Mean Age of Females at Necropsy (weeks)

Mean Age of Males at Necropsy (weeks)

0.3439 58 0.02157

0.3348 58 0.01593

0.2972 0.3939

0.3028 0.3726 /

/

24.4 2.62 63 17.0 31.0

2.26 0.152 51 1.88 2.59

/

/

/

1.07 0.095 61 0.85 1.29

1.82 0.062 59 1.67 1.96 /

/

1.83 0.068 59 1.70 2.09

0.75 0.033 59 0.66 0.83 /

/

0.72 0.030 59 0.63 0.77 /

24.5 63 2.45 17.0 31.0 /

0.1348 31 0.02491 0.0991 0.1705 /

/

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

1.956

0.880

1.696

1.694

0.684

0.660

0.30076

0.30294

19.60

0.08498

19.16

2.564

1.260

1.944

1.966

0.816

0.780

0.38704

0.36666

29.40

0.18462

29.64

1.804

0.785

1.634

1.626

0.651

0.630

0.27919

0.28701

17.15

0.06007

16.54

2.716

1.355

2.006

2.034

0.849

0.810

0.40861

0.38259

31.85

0.20953

32.26

Mean Combined Ovary w/o Oviduct Weight (g) 0.1192 22 0.01057 0.0957 0.1519 0.09806 0.14034 0.08749 0.15091 / / /

Mean Brain Weight (g) 2.15 59 0.036 2.078 2.222 2.042 2.258 / / 2.06 2.22 /

Mean Pituitary Weight (g) 0.016 55 0.0013 0.0129 0.0219 0.0134 0.0186 0.0121 0.0199 / / /

Mean Adrenal Weight (g) 0.061 54 0.0040 0.0528 0.0776 0.0530 0.0690 0.0490 0.0730 / / /

Mean Brain Weight (g) 1.98 59 0.033 1.914 2.046 1.881 2.079 / / 1.90 2.05 /

Mean Pituitary Weight (g) 0.021 55 0.0220 0.0138 0.1810 0 0.0650 0 0.0870 / / /

Mean Adrenal Weight (g) 0.087 54 0.0867 0.0581 0.7110 0 0.2604 0 0.3471 / / /

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Sex: Species:

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Number of Studies/Control Groups:

Study Type: 10/00 05/11 -

/

Strain:

Male/Female Rat

1-/2-Gen Crl:CD(SD)

Historical Control Summary of Sperm Concentration and Morphology

35 65

Mean S.D. N Mean -/+ 2 S.D. Min/Max Value

Mean Sperm Production Rate

Left Epididymis

Left Testis

Mean -/+ 3 S.D.

Left Cauda Epididymis

Mean Progressive Sperm Motility (%)

Mean Sperm Motility (%)

Mean Sperm Concentration

(millions/ gram of tissue)

(millions/ gram of tissue/ day)

Misshapen Head w/ Normal Flagellum

Head Absent w/ Normal Flagellum

Normal Head Separated from Flagellum

Head Absent w/ Abnormal Flagellum

Other Flagellar Defects w/ Normal Head

Degenerative Flagellar Defects w/ Normal Head

Sperm Morphology Differential Count (%)

Normal

Misshapen Head w/ Abnormal Flagellum

0.3 58 0.28

0.3 58 0.35

0.0 1.6

0.0 2.3 /

/

78.5 8.76 58 53.6 96.8

405.0 56.17 52 302.5 548.6

/

/

/

662.3 62.52 6 568.0 738.9

12.9 1.43 58 8.8 15.9 /

/

87.3 2.82 58 79.0 93.0

74.5 3.79 49 62.0 81.0 /

/

99.4 0.78 58 96.1 99.9 /

0.0 58 0.01 0.0 0.1 /

0.0 58 0.00 0.0 0.0 /

0.0 58 0.00 0.0 0.0 /

0.0 58 0.00 0.0 0.0 /

0.0 58 0.00 0.0 0.0 /

/

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

/ /

292.66

537.26

10.04

81.66

66.92

97.84

0.00

0.00

0.00

0.00

0.00

0.00

0.00

60.98

517.34

787.34

15.76

92.94

82.08

100.00

0.86

1.00

0.00

0.00

0.02

0.00

0.00

96.02

236.49

474.74

8.61

78.84

63.13

97.06

0.00

0.00

0.00

0.00

0.00

0.00

0.00

52.22

573.51

849.86

17.19

95.76

85.87

100.00

1.14

1.35

0.00

0.00

0.03

0.00

0.00

104.78

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Range of Study Dates:

Number of Studies/Control Groups:

Study Type: 12/11 12/12 -

/

Strain:

Male Rat

All Crl:CD(SD)

Historical Control Summary of Sperm Concentration and Morphology (IVOS v. 14)

9 9

Mean S.D. N Mean -/+ 2 S.D. Min/Max Value

Mean Sperm Production Rate

Left Epididymis

Left Testis

Mean -/+ 3 S.D.

Mean Progressive Sperm Motility (%)

Mean Sperm Motility (%)

Mean Sperm Concentration

(millions/ gram of tissue)

(millions/ gram of tissue/ day)

121.9 20.08 9 80.5 147.9

554.6 135.60 9 307.1 786.5

/

/

/

20.0 3.28 9 13.2 24.2 /

82.6 3.75 9 78.0 90.0

72.0 6.08 3 68.0 79.0 /

/

/

/ /

/ /

/ /

/ /

283.40

13.44

75.10

59.84

81.74

825.80

26.56

90.10

84.16

162.06

147.80

10.16

71.35

53.76

61.66

961.40

29.84

93.85

90.24

182.14

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FINAL REPORT

Contents: Volume 2 of 4 

Appendix G

Study Title: An Inhalation Reproduction/Developmental Toxicity

Screening Study of 2-Bromo-3,3,3-Trifluoropropene in Rats

Laboratory Project ID: WIL-65501

Author: Tammye L. Edwards, BS

Test Guideline: OECD Guideline 421

Study Completion Date: 21 March 2014

Performing Laboratory: WIL Research

1407 George Road

Ashland, OH 44805-8946

Sponsor: American Pacific Corporation

3883 Howard Hughes Parkway, Suite 700

Las Vegas, NV 89169

Total Number of Pages: 1107

 Page 298 of 1107
WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

APPENDIX G

Individual Animal Data

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 TABLE A1 (F0 MALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-12-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91555 M 0 PPM NORMAL 10-14-13 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91555 M 0 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA

 91560 M 0 PPM NORMAL 10-14-13 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91560 M 0 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA

 91562 M 0 PPM DISPOSITION 11-11-13 10:18 P SCHEDULED EUTHANASIA

 91562 M 0 PPM BODY/INTEGUMENT 10-14-13 6:45 1 HAIR LOSS RIGHT FORELIMB

 10-14-13 6:45 1 HAIR LOSS LEFT FORELIMB

 10-21-13 7:16 1 HAIR LOSS RIGHT FORELIMB

 10-21-13 7:16 1 HAIR LOSS LEFT FORELIMB

 10-27-13 6:39 1 HAIR LOSS RIGHT FORELIMB

 10-27-13 6:39 1 HAIR LOSS LEFT FORELIMB

 11-04-13 6:30 1 HAIR LOSS RIGHT FORELIMB

 11-04-13 6:30 1 HAIR LOSS LEFT FORELIMB

 11-11-13 7:36 2 HAIR LOSS LEFT FORELIMB

 11-11-13 7:36 2 HAIR LOSS RIGHT FORELIMB

 91563 M 0 PPM NORMAL 10-14-13 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91563 M 0 PPM DISPOSITION 11-11-13 10:19 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 300 of 1107
 TABLE A1 (F0 MALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-12-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91564 M 0 PPM NORMAL 10-14-13 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91564 M 0 PPM DISPOSITION 11-12-13 10:34 P SCHEDULED EUTHANASIA

 91567 M 0 PPM NORMAL 10-14-13 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91567 M 0 PPM DISPOSITION 11-11-13 10:18 P SCHEDULED EUTHANASIA

 91579 M 0 PPM NORMAL 10-14-13 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91579 M 0 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA

 91586 M 0 PPM NORMAL 10-14-13 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91586 M 0 PPM DISPOSITION 11-11-13 10:19 P SCHEDULED EUTHANASIA

 91591 M 0 PPM NORMAL 10-14-13 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91591 M 0 PPM DISPOSITION 11-11-13 10:20 P SCHEDULED EUTHANASIA

 91591 M 0 PPM BODY/INTEGUMENT 10-21-13 7:18 1 HAIR LOSS RIGHT FORELIMB

 10-21-13 7:18 1 HAIR LOSS LEFT FORELIMB

 10-27-13 6:40 1 HAIR LOSS RIGHT FORELIMB

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 301 of 1107
 TABLE A1 (F0 MALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-12-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91591 M 0 PPM BODY/INTEGUMENT 10-27-13 6:40 1 HAIR LOSS LEFT FORELIMB

 11-04-13 6:32 1 HAIR LOSS RIGHT FORELIMB

 11-04-13 6:32 1 HAIR LOSS LEFT FORELIMB

 11-11-13 7:39 1 HAIR LOSS RIGHT FORELIMB

 11-11-13 7:39 1 HAIR LOSS LEFT FORELIMB

 91592 M 0 PPM NORMAL 10-14-13 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91592 M 0 PPM DISPOSITION 11-12-13 10:34 P SCHEDULED EUTHANASIA

 91609 M 0 PPM NORMAL 10-14-13 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91609 M 0 PPM DISPOSITION 11-12-13 10:34 P SCHEDULED EUTHANASIA

 91615 M 0 PPM NORMAL 10-14-13 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91615 M 0 PPM DISPOSITION 11-11-13 10:19 P SCHEDULED EUTHANASIA

 91556 M 50 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA

 91556 M 50 PPM BODY/INTEGUMENT 10-14-13 6:50 1 HAIR LOSS RIGHT FORELIMB

 10-14-13 6:50 1 HAIR LOSS LEFT FORELIMB

 10-21-13 7:21 1 HAIR LOSS RIGHT FORELIMB

 10-21-13 7:21 1 HAIR LOSS LEFT FORELIMB

 10-27-13 6:41 1 HAIR LOSS RIGHT FORELIMB

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 302 of 1107
 TABLE A1 (F0 MALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-12-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91556 M 50 PPM BODY/INTEGUMENT 10-27-13 6:41 1 HAIR LOSS LEFT FORELIMB

 11-04-13 6:33 1 HAIR LOSS RIGHT FORELIMB

 11-04-13 6:33 1 HAIR LOSS LEFT FORELIMB

 11-11-13 7:42 2 HAIR LOSS RIGHT FORELIMB

 11-11-13 7:42 2 HAIR LOSS LEFT FORELIMB

 91559 M 50 PPM NORMAL 10-14-13 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91559 M 50 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA

 91561 M 50 PPM NORMAL 10-14-13 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91561 M 50 PPM DISPOSITION 11-11-13 10:20 P SCHEDULED EUTHANASIA

 91566 M 50 PPM NORMAL 10-14-13 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91566 M 50 PPM DISPOSITION 11-11-13 10:19 P SCHEDULED EUTHANASIA

 91576 M 50 PPM NORMAL 10-14-13 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91576 M 50 PPM DISPOSITION 11-11-13 10:19 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 303 of 1107
 TABLE A1 (F0 MALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-12-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91582 M 50 PPM NORMAL 10-14-13 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91582 M 50 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA

 91582 M 50 PPM BODY/INTEGUMENT 10-21-13 7:24 1 HAIR LOSS RIGHT FORELIMB

 10-21-13 7:24 1 HAIR LOSS LEFT FORELIMB

 91585 M 50 PPM NORMAL 10-14-13 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91585 M 50 PPM DISPOSITION 11-12-13 10:34 P SCHEDULED EUTHANASIA

 91585 M 50 PPM BODY/INTEGUMENT 11-11-13 7:45 1 HAIR LOSS RIGHT FORELIMB

 91589 M 50 PPM NORMAL 10-14-13 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91589 M 50 PPM DISPOSITION 11-11-13 10:19 P SCHEDULED EUTHANASIA

 91589 M 50 PPM BODY/INTEGUMENT 10-21-13 7:25 1 HAIR LOSS RIGHT FORELIMB

 10-21-13 7:25 1 HAIR LOSS LEFT FORELIMB

 10-27-13 6:43 1 HAIR LOSS RIGHT FORELIMB

 10-27-13 6:43 1 HAIR LOSS LEFT FORELIMB

 11-04-13 6:35 1 HAIR LOSS RIGHT FORELIMB

 11-04-13 6:35 1 HAIR LOSS LEFT FORELIMB

 11-11-13 7:46 3 HAIR LOSS RIGHT FORELIMB

 11-11-13 7:46 3 HAIR LOSS LEFT FORELIMB

 91593 M 50 PPM NORMAL 10-14-13 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91593 M 50 PPM DISPOSITION 11-11-13 10:20 P SCHEDULED EUTHANASIA

 91593 M 50 PPM BODY/INTEGUMENT 10-21-13 7:26 2 HAIR LOSS LEFT INGUINAL AREA

 10-27-13 6:43 1 HAIR LOSS LEFT INGUINAL AREA

 11-04-13 6:35 1 HAIR LOSS LEFT INGUINAL AREA

 11-11-13 7:47 2 HAIR LOSS LEFT FORELIMB

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 304 of 1107
 TABLE A1 (F0 MALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-12-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91594 M 50 PPM NORMAL 10-14-13 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91594 M 50 PPM DISPOSITION 11-11-13 10:18 P SCHEDULED EUTHANASIA

 91595 M 50 PPM NORMAL 10-14-13 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91595 M 50 PPM DISPOSITION 11-12-13 10:34 P SCHEDULED EUTHANASIA

 91602 M 50 PPM NORMAL 10-14-13 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91602 M 50 PPM DISPOSITION 11-12-13 10:34 P SCHEDULED EUTHANASIA

 91569 M 100 PPM NORMAL 10-14-13 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91569 M 100 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA

 91569 M 100 PPM BODY/INTEGUMENT 10-21-13 7:28 1 HAIR LOSS RIGHT FORELIMB

 10-21-13 7:28 1 HAIR LOSS LEFT FORELIMB

 10-27-13 6:45 1 HAIR LOSS RIGHT FORELIMB

 10-27-13 6:45 1 HAIR LOSS LEFT FORELIMB

 11-04-13 6:38 1 HAIR LOSS RIGHT FORELIMB

 11-04-13 6:38 1 HAIR LOSS LEFT FORELIMB

 11-11-13 7:48 2 HAIR LOSS RIGHT FORELIMB

 11-11-13 7:48 2 HAIR LOSS LEFT FORELIMB

 91573 M 100 PPM DISPOSITION 11-11-13 10:19 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 305 of 1107
 TABLE A1 (F0 MALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-12-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91573 M 100 PPM BODY/INTEGUMENT 10-14-13 6:57 1 HAIR LOSS RIGHT FORELIMB

 10-14-13 6:57 1 HAIR LOSS LEFT FORELIMB

 10-21-13 7:29 1 HAIR LOSS RIGHT FORELIMB

 10-21-13 7:29 1 HAIR LOSS LEFT FORELIMB

 11-11-13 7:49 2 HAIR LOSS RIGHT FORELIMB

 11-11-13 7:49 2 HAIR LOSS LEFT FORELIMB

 91573 M 100 PPM EYES/EARS/NOSE 10-27-13 6:46 1 DRIED RED MATERIAL AROUND LEFT EYE

 11-04-13 6:39 1 DRIED RED MATERIAL AROUND LEFT EYE

 11-04-13 6:39 1 DRIED RED MATERIAL AROUND RIGHT EYE

 11-11-13 7:49 2 DRIED RED MATERIAL AROUND LEFT EYE

 11-11-13 7:49 2 DRIED RED MATERIAL AROUND RIGHT EYE

 91573 M 100 PPM ORAL/DENTAL 10-27-13 6:46 P UPPER INCISORS MALALIGNED

 10-27-13 6:46 P TEETH LONG; TRIMMED

 11-04-13 6:39 P UPPER INCISORS MALALIGNED

 11-04-13 6:39 P TEETH LONG; TRIMMED

 11-11-13 7:49 P UPPER INCISORS MALALIGNED

 91577 M 100 PPM NORMAL 10-14-13 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91577 M 100 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA

 91581 M 100 PPM NORMAL 10-14-13 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91581 M 100 PPM DISPOSITION 11-11-13 10:20 P SCHEDULED EUTHANASIA

 91583 M 100 PPM NORMAL 10-14-13 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 306 of 1107
 TABLE A1 (F0 MALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-12-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91583 M 100 PPM DISPOSITION 11-11-13 10:18 P SCHEDULED EUTHANASIA

 91583 M 100 PPM BODY/INTEGUMENT 10-21-13 7:30 1 HAIR LOSS RIGHT FORELIMB

 10-21-13 7:30 1 HAIR LOSS LEFT FORELIMB

 10-27-13 6:47 1 HAIR LOSS RIGHT FORELIMB

 10-27-13 6:47 1 HAIR LOSS LEFT FORELIMB

 11-04-13 6:40 1 HAIR LOSS RIGHT FORELIMB

 11-04-13 6:40 1 HAIR LOSS LEFT FORELIMB

 11-11-13 7:51 1 HAIR LOSS RIGHT FORELIMB

 11-11-13 7:51 2 HAIR LOSS LEFT FORELIMB

 91588 M 100 PPM NORMAL 10-14-13 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91588 M 100 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA

 91590 M 100 PPM NORMAL 10-14-13 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91590 M 100 PPM DISPOSITION 11-11-13 10:18 P SCHEDULED EUTHANASIA

 91598 M 100 PPM NORMAL 10-14-13 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91598 M 100 PPM DISPOSITION 11-12-13 10:34 P SCHEDULED EUTHANASIA

 91599 M 100 PPM NORMAL 10-14-13 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 307 of 1107
 TABLE A1 (F0 MALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-12-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91599 M 100 PPM NORMAL 10-27-13 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91599 M 100 PPM DISPOSITION 11-11-13 10:18 P SCHEDULED EUTHANASIA

 91608 M 100 PPM NORMAL 10-14-13 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91608 M 100 PPM DISPOSITION 11-12-13 10:34 P SCHEDULED EUTHANASIA

 91611 M 100 PPM NORMAL 10-14-13 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91611 M 100 PPM DISPOSITION 11-11-13 10:19 P SCHEDULED EUTHANASIA

 91616 M 100 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA

 91616 M 100 PPM BODY/INTEGUMENT 10-14-13 7:02 1 HAIR LOSS RIGHT FORELIMB

 10-14-13 7:02 1 HAIR LOSS LEFT FORELIMB

 10-21-13 7:33 1 HAIR LOSS RIGHT FORELIMB

 10-21-13 7:33 1 HAIR LOSS LEFT FORELIMB

 10-27-13 6:49 1 HAIR LOSS RIGHT FORELIMB

 10-27-13 6:49 1 HAIR LOSS LEFT FORELIMB

 11-04-13 6:42 1 HAIR LOSS RIGHT FORELIMB

 11-04-13 6:42 1 HAIR LOSS LEFT FORELIMB

 11-11-13 7:54 3 HAIR LOSS RIGHT FORELIMB

 11-11-13 7:54 3 HAIR LOSS LEFT FORELIMB

 91565 M 175 PPM NORMAL 10-14-13 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 308 of 1107
 TABLE A1 (F0 MALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-12-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91565 M 175 PPM NORMAL 10-27-13 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91565 M 175 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA

 91568 M 175 PPM NORMAL 10-14-13 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91568 M 175 PPM DISPOSITION 11-11-13 10:18 P SCHEDULED EUTHANASIA

 91570 M 175 PPM NORMAL 10-14-13 7:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91570 M 175 PPM DISPOSITION 11-11-13 10:19 P SCHEDULED EUTHANASIA

 91572 M 175 PPM NORMAL 10-14-13 7:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91572 M 175 PPM DISPOSITION 11-12-13 10:34 P SCHEDULED EUTHANASIA

 91572 M 175 PPM BODY/INTEGUMENT 10-21-13 7:41 2 HAIR LOSS RIGHT FORELIMB

 10-21-13 7:41 2 HAIR LOSS LEFT FORELIMB

 10-27-13 6:50 1 HAIR LOSS RIGHT FORELIMB

 10-27-13 6:50 1 HAIR LOSS LEFT FORELIMB

 11-04-13 6:43 1 HAIR LOSS RIGHT FORELIMB

 11-04-13 6:43 1 HAIR LOSS LEFT FORELIMB

 11-11-13 7:56 3 HAIR LOSS RIGHT FORELIMB

 11-11-13 7:56 3 HAIR LOSS LEFT FORELIMB

 91580 M 175 PPM NORMAL 10-14-13 7:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 309 of 1107
 TABLE A1 (F0 MALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 11

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-12-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91580 M 175 PPM NORMAL 11-04-13 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91580 M 175 PPM DISPOSITION 11-12-13 10:34 P SCHEDULED EUTHANASIA

 91584 M 175 PPM NORMAL 10-14-13 7:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91584 M 175 PPM DISPOSITION 11-11-13 10:20 P SCHEDULED EUTHANASIA

 91587 M 175 PPM DISPOSITION 11-11-13 10:18 P SCHEDULED EUTHANASIA

 91587 M 175 PPM BODY/INTEGUMENT 10-14-13 7:06 1 HAIR LOSS LEFT FORELIMB

 10-21-13 7:42 1 HAIR LOSS RIGHT FORELIMB

 10-21-13 7:42 1 HAIR LOSS LEFT FORELIMB

 10-27-13 6:50 1 HAIR LOSS RIGHT FORELIMB

 10-27-13 6:50 1 HAIR LOSS LEFT FORELIMB

 11-04-13 6:44 1 HAIR LOSS RIGHT FORELIMB

 11-04-13 6:44 1 HAIR LOSS LEFT FORELIMB

 11-11-13 7:58 3 HAIR LOSS RIGHT FORELIMB

 11-11-13 7:58 3 HAIR LOSS LEFT FORELIMB

 91597 M 175 PPM NORMAL 10-14-13 7:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91597 M 175 PPM DISPOSITION 11-12-13 10:34 P SCHEDULED EUTHANASIA

 91597 M 175 PPM BODY/INTEGUMENT 10-21-13 7:43 1 HAIR LOSS LEFT FORELIMB

 91601 M 175 PPM NORMAL 10-14-13 7:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 310 of 1107
 TABLE A1 (F0 MALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 12

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-12-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91601 M 175 PPM DISPOSITION 11-11-13 10:19 P SCHEDULED EUTHANASIA

 91601 M 175 PPM BODY/INTEGUMENT 11-11-13 7:59 1 HAIR LOSS RIGHT FORELIMB

 11-11-13 7:59 1 HAIR LOSS LEFT FORELIMB

 91607 M 175 PPM NORMAL 10-14-13 7:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91607 M 175 PPM DISPOSITION 11-11-13 10:18 P SCHEDULED EUTHANASIA

 91607 M 175 PPM BODY/INTEGUMENT 10-21-13 7:44 1 HAIR LOSS RIGHT FORELIMB

 10-21-13 7:44 1 HAIR LOSS LEFT FORELIMB

 10-27-13 6:51 1 HAIR LOSS RIGHT FORELIMB

 10-27-13 6:51 1 HAIR LOSS LEFT FORELIMB

 11-04-13 6:45 1 HAIR LOSS RIGHT FORELIMB

 11-04-13 6:45 1 HAIR LOSS LEFT FORELIMB

 11-11-13 7:59 3 HAIR LOSS RIGHT FORELIMB

 11-11-13 7:59 3 HAIR LOSS LEFT FORELIMB

 91613 M 175 PPM NORMAL 10-14-13 7:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91613 M 175 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA

 91614 M 175 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA

 91614 M 175 PPM BODY/INTEGUMENT 10-14-13 7:09 2 HAIR LOSS RIGHT FORELIMB

 10-14-13 7:09 2 HAIR LOSS LEFT FORELIMB

 10-21-13 7:45 2 HAIR LOSS RIGHT FORELIMB

 10-21-13 7:45 2 HAIR LOSS LEFT FORELIMB

 10-27-13 6:52 2 HAIR LOSS RIGHT FORELIMB

 10-27-13 6:52 2 HAIR LOSS LEFT FORELIMB

 11-04-13 6:46 2 HAIR LOSS RIGHT FORELIMB

 11-04-13 6:46 2 HAIR LOSS LEFT FORELIMB

 11-11-13 8:00 3 HAIR LOSS RIGHT FORELIMB

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 311 of 1107
 TABLE A1 (F0 MALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 13

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-12-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91614 M 175 PPM BODY/INTEGUMENT 11-11-13 8:00 3 HAIR LOSS LEFT FORELIMB

 91554 M 10000 PPM NORMAL 10-14-13 7:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91554 M 10000 PPM DISPOSITION 11-11-13 10:20 P SCHEDULED EUTHANASIA

 91557 M 10000 PPM NORMAL 10-14-13 7:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91557 M 10000 PPM DISPOSITION 11-11-13 10:19 P SCHEDULED EUTHANASIA

 91558 M 10000 PPM NORMAL 10-14-13 7:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91558 M 10000 PPM DISPOSITION 11-11-13 10:18 P SCHEDULED EUTHANASIA

 91571 M 10000 PPM NORMAL 10-14-13 7:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91571 M 10000 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA

 91575 M 10000 PPM NORMAL 10-14-13 7:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 312 of 1107
 TABLE A1 (F0 MALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 14

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-12-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91575 M 10000 PPM NORMAL 11-11-13 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91575 M 10000 PPM DISPOSITION 11-11-13 10:19 P SCHEDULED EUTHANASIA

 91600 M 10000 PPM NORMAL 10-14-13 7:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 8:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91600 M 10000 PPM DISPOSITION 11-12-13 10:34 P SCHEDULED EUTHANASIA

 91603 M 10000 PPM NORMAL 10-14-13 7:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 8:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91603 M 10000 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA

 91604 M 10000 PPM NORMAL 10-14-13 7:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91604 M 10000 PPM DISPOSITION 11-11-13 10:18 P SCHEDULED EUTHANASIA

 91604 M 10000 PPM BODY/INTEGUMENT 11-11-13 8:03 1 HAIR LOSS RIGHT FORELIMB

 91605 M 10000 PPM NORMAL 10-14-13 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91605 M 10000 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA

 91612 M 10000 PPM NORMAL 10-14-13 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 313 of 1107
 TABLE A1 (F0 MALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 15

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-12-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91612 M 10000 PPM NORMAL 11-04-13 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91612 M 10000 PPM DISPOSITION 11-12-13 10:33 P SCHEDULED EUTHANASIA

 91618 M 10000 PPM DISPOSITION 11-12-13 10:34 P SCHEDULED EUTHANASIA

 91618 M 10000 PPM BODY/INTEGUMENT 10-14-13 7:15 1 HAIR LOSS RIGHT FORELIMB

 10-14-13 7:15 1 HAIR LOSS LEFT FORELIMB

 10-21-13 7:50 1 HAIR LOSS RIGHT FORELIMB

 10-21-13 7:50 1 HAIR LOSS LEFT FORELIMB

 10-27-13 6:54 1 HAIR LOSS RIGHT FORELIMB

 10-27-13 6:54 1 HAIR LOSS LEFT FORELIMB

 11-04-13 6:49 1 HAIR LOSS RIGHT FORELIMB

 11-04-13 6:49 1 HAIR LOSS LEFT FORELIMB

 11-11-13 8:04 2 HAIR LOSS RIGHT FORELIMB

 11-11-13 8:04 2 HAIR LOSS LEFT FORELIMB

 91619 M 10000 PPM NORMAL 10-14-13 7:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 8:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91619 M 10000 PPM DISPOSITION 11-11-13 10:19 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

 PCRDv4.18

 11/25/2013

Page 314 of 1107
 TABLE A2 (F0 MALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91554 M 10000 PPM NORMAL 10-22-13 12:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 13:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 11:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91554 M 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY

 91554 M 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION

 91554 M 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT

 10-14-13 13:26 P LACRIMATION

 10-17-13 11:51 1 WET RED MATERIAL AROUND NOSE

 91554 M 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION

 10-15-13 12:23 1 SALIVATION

 10-16-13 12:15 1 SALIVATION

 10-17-13 11:51 1 SALIVATION

 10-18-13 11:45 1 SALIVATION

 10-19-13 11:22 1 SALIVATION

 10-20-13 11:18 1 SALIVATION

 10-21-13 12:32 2 SALIVATION

 10-23-13 11:43 1 SALIVATION

 10-23-13 11:43 2 WET CLEAR MATERIAL AROUND MOUTH

 10-25-13 14:10 1 SALIVATION

 10-26-13 11:52 1 SALIVATION

 10-28-13 12:54 1 WET CLEAR MATERIAL AROUND MOUTH

 10-28-13 12:54 2 SALIVATION

 10-29-13 12:27 2 WET CLEAR MATERIAL AROUND MOUTH

 10-29-13 12:27 2 SALIVATION

 10-30-13 12:26 1 WET CLEAR MATERIAL AROUND MOUTH

 10-31-13 11:50 2 SALIVATION

 11-01-13 11:36 2 WET CLEAR MATERIAL AROUND MOUTH

 11-01-13 11:36 2 SALIVATION

 11-02-13 11:34 3 WET CLEAR MATERIAL AROUND MOUTH

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 315 of 1107
 TABLE A2 (F0 MALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91554 M 10000 PPM ORAL/DENTAL 11-02-13 11:34 2 SALIVATION

 11-03-13 11:15 2 SALIVATION

 11-04-13 12:05 1 WET CLEAR MATERIAL AROUND MOUTH

 11-04-13 12:05 2 SALIVATION

 11-05-13 11:21 1 WET CLEAR MATERIAL AROUND MOUTH

 11-05-13 11:21 1 SALIVATION

 11-06-13 11:43 2 WET CLEAR MATERIAL AROUND MOUTH

 11-06-13 11:43 2 SALIVATION

 11-07-13 11:57 2 WET CLEAR MATERIAL AROUND MOUTH

 11-07-13 11:57 2 SALIVATION

 11-08-13 13:01 1 WET CLEAR MATERIAL AROUND MOUTH

 11-08-13 13:01 1 SALIVATION

 11-09-13 11:52 1 SALIVATION

 11-10-13 13:11 1 SALIVATION

 91557 M 10000 PPM NORMAL 10-17-13 11:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 11:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 11:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 12:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 13:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 11:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91557 M 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY

 91557 M 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION

 91557 M 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT

 10-14-13 13:26 P LACRIMATION

 10-26-13 11:52 1 DRIED RED MATERIAL AROUND LEFT EYE

 11-01-13 11:36 2 WET RED MATERIAL AROUND NOSE

 91557 M 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION

 10-15-13 12:23 2 WET CLEAR MATERIAL AROUND MOUTH

 10-16-13 12:14 1 SALIVATION

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 316 of 1107
 TABLE A2 (F0 MALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91557 M 10000 PPM ORAL/DENTAL 10-19-13 11:22 1 SALIVATION

 10-21-13 12:32 1 SALIVATION

 10-23-13 11:42 1 SALIVATION

 10-23-13 11:42 1 WET CLEAR MATERIAL AROUND MOUTH

 10-25-13 14:10 1 SALIVATION

 10-27-13 11:46 1 SALIVATION

 10-28-13 12:54 3 WET CLEAR MATERIAL AROUND MOUTH

 10-29-13 12:27 2 WET CLEAR MATERIAL AROUND MOUTH

 10-29-13 12:27 2 SALIVATION

 10-30-13 12:26 1 SALIVATION

 10-31-13 11:50 2 WET CLEAR MATERIAL AROUND MOUTH

 10-31-13 11:50 1 SALIVATION

 11-01-13 11:37 2 WET CLEAR MATERIAL AROUND MOUTH

 11-01-13 11:37 2 SALIVATION

 11-02-13 11:34 3 WET CLEAR MATERIAL AROUND MOUTH

 11-02-13 11:34 3 SALIVATION

 11-03-13 11:15 3 WET CLEAR MATERIAL AROUND MOUTH

 11-03-13 11:15 3 SALIVATION

 11-04-13 12:05 3 WET CLEAR MATERIAL AROUND MOUTH

 11-04-13 12:05 3 SALIVATION

 11-05-13 11:22 3 WET CLEAR MATERIAL AROUND MOUTH

 11-05-13 11:22 3 SALIVATION

 11-07-13 11:58 3 WET CLEAR MATERIAL AROUND MOUTH

 11-07-13 11:58 3 SALIVATION

 11-08-13 13:02 3 WET CLEAR MATERIAL AROUND MOUTH

 11-08-13 13:02 3 SALIVATION

 11-09-13 11:52 2 SALIVATION

 11-10-13 13:11 1 SALIVATION

 91558 M 10000 PPM NORMAL 10-25-13 14:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 317 of 1107
 TABLE A2 (F0 MALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91558 M 10000 PPM NORMAL 10-26-13 11:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91558 M 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY

 91558 M 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION

 91558 M 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT

 10-14-13 13:26 P LACRIMATION

 10-17-13 11:56 1 WET RED MATERIAL AROUND NOSE

 91558 M 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION

 10-15-13 12:19 1 SALIVATION

 10-16-13 12:12 2 SALIVATION

 10-17-13 11:56 1 SALIVATION

 10-18-13 11:45 1 SALIVATION

 10-18-13 11:45 2 WET CLEAR MATERIAL AROUND MOUTH

 10-19-13 11:24 1 SALIVATION

 10-20-13 11:20 1 SALIVATION

 10-21-13 12:36 1 SALIVATION

 10-22-13 12:03 1 SALIVATION

 10-23-13 11:47 2 SALIVATION

 10-24-13 13:40 1 SALIVATION

 10-28-13 12:55 3 WET CLEAR MATERIAL AROUND MOUTH

 10-28-13 12:55 3 SALIVATION

 10-29-13 12:28 3 WET CLEAR MATERIAL AROUND MOUTH

 10-29-13 12:28 3 SALIVATION

 10-30-13 12:27 1 SALIVATION

 10-31-13 11:51 2 WET CLEAR MATERIAL AROUND MOUTH

 10-31-13 11:51 1 SALIVATION

 11-01-13 11:38 3 WET CLEAR MATERIAL AROUND MOUTH

 11-01-13 11:38 3 SALIVATION

 11-02-13 11:36 3 WET CLEAR MATERIAL AROUND MOUTH

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 318 of 1107
 TABLE A2 (F0 MALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

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 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91558 M 10000 PPM ORAL/DENTAL 11-02-13 11:36 3 SALIVATION

 11-03-13 11:16 2 WET CLEAR MATERIAL AROUND MOUTH

 11-03-13 11:16 1 SALIVATION

 11-04-13 12:06 3 WET CLEAR MATERIAL AROUND MOUTH

 11-04-13 12:06 3 SALIVATION

 11-05-13 11:23 2 WET CLEAR MATERIAL AROUND MOUTH

 11-05-13 11:23 1 SALIVATION

 11-06-13 11:44 1 WET CLEAR MATERIAL AROUND MOUTH

 11-06-13 11:44 1 SALIVATION

 11-07-13 11:59 3 WET CLEAR MATERIAL AROUND MOUTH

 11-07-13 11:59 3 SALIVATION

 11-08-13 13:03 2 WET CLEAR MATERIAL AROUND MOUTH

 11-08-13 13:03 2 SALIVATION

 11-09-13 11:55 1 SALIVATION

 11-10-13 13:12 2 SALIVATION

 91571 M 10000 PPM NORMAL 10-16-13 12:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 11:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 13:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91571 M 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY

 91571 M 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION

 91571 M 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT

 10-14-13 13:26 P LACRIMATION

 91571 M 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION

 10-15-13 12:24 1 SALIVATION

 10-17-13 11:50 1 WET CLEAR MATERIAL AROUND MOUTH

 10-19-13 11:21 1 SALIVATION

 10-20-13 11:18 1 SALIVATION

 10-21-13 12:33 1 SALIVATION

 10-22-13 12:02 1 SALIVATION

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 319 of 1107
 TABLE A2 (F0 MALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

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 TABLE RANGE: 10-14-13 TO 11-11-13

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 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91571 M 10000 PPM ORAL/DENTAL 10-23-13 11:44 1 SALIVATION

 10-25-13 14:10 1 SALIVATION

 10-26-13 11:53 1 SALIVATION

 10-27-13 11:47 1 SALIVATION

 10-28-13 12:53 2 WET CLEAR MATERIAL AROUND MOUTH

 10-28-13 12:53 2 SALIVATION

 10-29-13 12:26 2 SALIVATION

 10-29-13 12:26 2 WET CLEAR MATERIAL AROUND MOUTH

 10-30-13 12:26 1 SALIVATION

 10-31-13 11:49 3 WET CLEAR MATERIAL AROUND MOUTH

 10-31-13 11:49 3 SALIVATION

 11-01-13 11:36 2 WET CLEAR MATERIAL AROUND MOUTH

 11-01-13 11:36 2 SALIVATION

 11-02-13 11:33 3 WET CLEAR MATERIAL AROUND MOUTH

 11-02-13 11:33 3 SALIVATION

 11-03-13 11:14 3 WET CLEAR MATERIAL AROUND MOUTH

 11-03-13 11:14 3 SALIVATION

 11-04-13 12:04 1 WET CLEAR MATERIAL AROUND MOUTH

 11-04-13 12:04 1 SALIVATION

 11-05-13 11:21 1 WET CLEAR MATERIAL AROUND MOUTH

 11-05-13 11:21 1 SALIVATION

 11-06-13 11:42 2 WET CLEAR MATERIAL AROUND MOUTH

 11-06-13 11:42 2 SALIVATION

 11-07-13 11:57 3 WET CLEAR MATERIAL AROUND MOUTH

 11-07-13 11:57 2 SALIVATION

 11-08-13 13:01 3 WET CLEAR MATERIAL AROUND MOUTH

 11-08-13 13:01 3 SALIVATION

 11-09-13 11:51 1 SALIVATION

 11-10-13 13:11 1 SALIVATION

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 320 of 1107
 TABLE A2 (F0 MALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91571 M 10000 PPM ORAL/DENTAL 11-11-13 12:43 2 WET CLEAR MATERIAL AROUND MOUTH

 11-11-13 12:43 2 SALIVATION

 91575 M 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY

 91575 M 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION

 91575 M 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT

 10-14-13 13:26 P LACRIMATION

 91575 M 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION

 10-15-13 12:21 1 WET CLEAR MATERIAL AROUND MOUTH

 10-16-13 12:13 1 WET RED MATERIAL AROUND MOUTH

 10-17-13 11:53 1 SALIVATION

 10-18-13 11:47 1 WET RED MATERIAL AROUND MOUTH

 10-19-13 11:23 1 WET RED MATERIAL AROUND MOUTH

 10-20-13 11:16 1 SALIVATION

 10-21-13 12:31 2 SALIVATION

 10-22-13 12:00 1 SALIVATION

 10-23-13 11:41 2 SALIVATION

 10-23-13 11:41 1 WET CLEAR MATERIAL AROUND MOUTH

 10-24-13 13:38 1 SALIVATION

 10-25-13 14:09 1 SALIVATION

 10-26-13 11:51 1 SALIVATION

 10-27-13 11:46 1 SALIVATION

 10-28-13 12:54 3 WET CLEAR MATERIAL AROUND MOUTH

 10-28-13 12:55 2 SALIVATION

 10-29-13 12:28 3 WET CLEAR MATERIAL AROUND MOUTH

 10-29-13 12:28 3 SALIVATION

 10-30-13 12:25 1 SALIVATION

 10-31-13 11:51 2 WET CLEAR MATERIAL AROUND MOUTH

 10-31-13 11:51 1 SALIVATION

 11-01-13 11:37 2 WET CLEAR MATERIAL AROUND MOUTH

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 321 of 1107
 TABLE A2 (F0 MALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8

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 TABLE RANGE: 10-14-13 TO 11-11-13

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 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91575 M 10000 PPM ORAL/DENTAL 11-01-13 11:37 1 SALIVATION

 11-02-13 11:35 2 WET CLEAR MATERIAL AROUND MOUTH

 11-02-13 11:35 1 SALIVATION

 11-03-13 11:15 3 WET CLEAR MATERIAL AROUND MOUTH

 11-03-13 11:15 3 SALIVATION

 11-04-13 12:05 3 WET CLEAR MATERIAL AROUND MOUTH

 11-04-13 12:05 3 SALIVATION

 11-05-13 11:22 3 WET CLEAR MATERIAL AROUND MOUTH

 11-05-13 11:22 3 SALIVATION

 11-06-13 11:43 3 WET CLEAR MATERIAL AROUND MOUTH

 11-06-13 11:43 2 SALIVATION

 11-07-13 11:58 3 WET CLEAR MATERIAL AROUND MOUTH

 11-07-13 11:58 3 SALIVATION

 11-08-13 13:02 3 WET CLEAR MATERIAL AROUND MOUTH

 11-08-13 13:02 3 SALIVATION

 11-09-13 11:53 1 SALIVATION

 11-10-13 13:12 2 SALIVATION

 91600 M 10000 PPM NORMAL 10-24-13 13:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 11:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91600 M 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY

 91600 M 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION

 91600 M 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT

 10-14-13 13:26 P LACRIMATION

 91600 M 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION

 10-15-13 12:24 1 SALIVATION

 10-16-13 12:15 1 SALIVATION

 10-17-13 11:52 1 SALIVATION

 10-18-13 11:44 2 SALIVATION

 10-18-13 11:44 2 WET CLEAR MATERIAL AROUND MOUTH

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 322 of 1107
 TABLE A2 (F0 MALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91600 M 10000 PPM ORAL/DENTAL 10-19-13 11:21 1 SALIVATION

 10-19-13 11:21 1 WET CLEAR MATERIAL AROUND MOUTH

 10-20-13 11:18 2 SALIVATION

 10-21-13 12:33 2 SALIVATION

 10-22-13 12:01 2 SALIVATION

 10-23-13 11:44 1 SALIVATION

 10-23-13 11:44 1 WET CLEAR MATERIAL AROUND MOUTH

 10-25-13 14:10 1 SALIVATION

 10-26-13 11:53 1 SALIVATION

 10-28-13 12:53 3 WET CLEAR MATERIAL AROUND MOUTH

 10-29-13 12:26 3 WET CLEAR MATERIAL AROUND MOUTH

 10-29-13 12:26 3 SALIVATION

 10-30-13 12:26 1 WET CLEAR MATERIAL AROUND MOUTH

 10-31-13 11:49 3 WET CLEAR MATERIAL AROUND MOUTH

 10-31-13 11:49 3 SALIVATION

 11-01-13 11:36 2 WET CLEAR MATERIAL AROUND MOUTH

 11-01-13 11:36 2 SALIVATION

 11-02-13 11:34 3 WET CLEAR MATERIAL AROUND MOUTH

 11-02-13 11:34 2 SALIVATION

 11-03-13 11:14 3 WET CLEAR MATERIAL AROUND MOUTH

 11-03-13 11:14 3 SALIVATION

 11-04-13 12:04 2 WET CLEAR MATERIAL AROUND MOUTH

 11-04-13 12:04 2 SALIVATION

 11-05-13 11:21 3 WET CLEAR MATERIAL AROUND MOUTH

 11-05-13 11:21 3 SALIVATION

 11-06-13 11:43 2 WET CLEAR MATERIAL AROUND MOUTH

 11-06-13 11:43 2 SALIVATION

 11-07-13 11:57 2 WET CLEAR MATERIAL AROUND MOUTH

 11-07-13 11:57 2 SALIVATION

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 323 of 1107
 TABLE A2 (F0 MALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91600 M 10000 PPM ORAL/DENTAL 11-08-13 13:01 3 WET CLEAR MATERIAL AROUND MOUTH

 11-08-13 13:01 3 SALIVATION

 11-09-13 11:51 2 SALIVATION

 11-10-13 13:11 1 WET CLEAR MATERIAL AROUND MOUTH

 11-11-13 12:43 3 WET CLEAR MATERIAL AROUND MOUTH

 11-11-13 12:43 1 SALIVATION

 91603 M 10000 PPM NORMAL 10-15-13 12:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 11:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 11:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 12:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 12:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 13:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 14:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 11:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 11:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 12:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 11:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 11:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 11:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 11:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 13:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 12:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91603 M 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY

 91603 M 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION

 91603 M 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT

 10-14-13 13:26 P LACRIMATION

 91603 M 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION

 10-18-13 11:46 1 SALIVATION

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 324 of 1107
 TABLE A2 (F0 MALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 11

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91603 M 10000 PPM ORAL/DENTAL 10-18-13 11:46 1 WET CLEAR MATERIAL AROUND MOUTH

 10-19-13 11:22 1 WET CLEAR MATERIAL AROUND MOUTH

 10-23-13 11:42 1 WET CLEAR MATERIAL AROUND MOUTH

 10-28-13 12:54 3 WET CLEAR MATERIAL AROUND MOUTH

 10-28-13 12:54 3 SALIVATION

 10-29-13 12:27 2 WET CLEAR MATERIAL AROUND MOUTH

 10-31-13 11:51 2 WET CLEAR MATERIAL AROUND MOUTH

 10-31-13 11:51 1 SALIVATION

 11-04-13 12:05 2 WET CLEAR MATERIAL AROUND MOUTH

 11-06-13 11:43 3 WET CLEAR MATERIAL AROUND MOUTH

 11-06-13 11:43 1 SALIVATION

 11-07-13 11:58 2 WET CLEAR MATERIAL AROUND MOUTH

 11-09-13 11:53 2 WET CLEAR MATERIAL AROUND MOUTH

 11-10-13 13:12 1 SALIVATION

 91604 M 10000 PPM NORMAL 10-18-13 11:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 13:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 11:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91604 M 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY

 91604 M 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION

 91604 M 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT

 10-14-13 13:26 P LACRIMATION

 91604 M 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION

 10-15-13 12:21 1 WET CLEAR MATERIAL AROUND MOUTH

 10-16-13 12:16 1 WET CLEAR MATERIAL AROUND MOUTH

 10-16-13 12:16 2 SALIVATION

 10-17-13 11:58 1 WET CLEAR MATERIAL AROUND MOUTH

 10-19-13 11:23 1 SALIVATION

 10-20-13 11:21 1 SALIVATION

 10-21-13 12:38 1 SALIVATION

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 325 of 1107
 TABLE A2 (F0 MALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 12

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91604 M 10000 PPM ORAL/DENTAL 10-22-13 12:04 1 SALIVATION

 10-23-13 11:48 1 SALIVATION

 10-23-13 11:48 1 WET CLEAR MATERIAL AROUND MOUTH

 10-25-13 14:12 1 SALIVATION

 10-27-13 11:48 1 WET CLEAR MATERIAL AROUND MOUTH

 10-28-13 12:55 2 WET CLEAR MATERIAL AROUND MOUTH

 10-29-13 12:28 2 WET CLEAR MATERIAL AROUND MOUTH

 10-29-13 12:28 2 SALIVATION

 10-30-13 12:27 1 SALIVATION

 10-31-13 11:51 3 WET CLEAR MATERIAL AROUND MOUTH

 10-31-13 11:51 3 SALIVATION

 11-01-13 11:38 3 WET CLEAR MATERIAL AROUND MOUTH

 11-01-13 11:38 3 SALIVATION

 11-02-13 11:35 3 WET CLEAR MATERIAL AROUND MOUTH

 11-02-13 11:35 3 SALIVATION

 11-03-13 11:16 2 WET CLEAR MATERIAL AROUND MOUTH

 11-03-13 11:16 2 SALIVATION

 11-04-13 12:06 2 WET CLEAR MATERIAL AROUND MOUTH

 11-04-13 12:06 2 SALIVATION

 11-05-13 11:23 3 WET CLEAR MATERIAL AROUND MOUTH

 11-05-13 11:23 3 SALIVATION

 11-06-13 11:44 3 WET CLEAR MATERIAL AROUND MOUTH

 11-06-13 11:44 3 SALIVATION

 11-07-13 11:58 3 WET CLEAR MATERIAL AROUND MOUTH

 11-07-13 11:58 3 SALIVATION

 11-08-13 13:02 2 WET CLEAR MATERIAL AROUND MOUTH

 11-08-13 13:02 2 SALIVATION

 11-09-13 11:55 2 SALIVATION

 11-10-13 13:12 2 SALIVATION

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 326 of 1107
 TABLE A2 (F0 MALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 13

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91605 M 10000 PPM NORMAL 10-15-13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 12:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 12:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 13:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 14:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 11:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91605 M 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY

 91605 M 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION

 91605 M 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT

 10-14-13 13:26 P LACRIMATION

 10-17-13 11:55 1 WET RED MATERIAL AROUND NOSE

 10-18-13 11:46 1 WET RED MATERIAL AROUND NOSE

 10-28-13 12:56 2 WET RED MATERIAL AROUND NOSE

 11-01-13 11:38 2 WET RED MATERIAL AROUND NOSE

 91605 M 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION

 10-17-13 11:55 1 WET RED MATERIAL AROUND MOUTH

 10-18-13 11:46 1 SALIVATION

 10-18-13 11:46 1 WET CLEAR MATERIAL AROUND MOUTH

 10-19-13 11:24 1 WET CLEAR MATERIAL AROUND MOUTH

 10-19-13 11:24 1 SALIVATION

 10-20-13 11:19 1 SALIVATION

 10-21-13 12:36 1 WET CLEAR MATERIAL AROUND MOUTH

 10-23-13 11:46 1 SALIVATION

 10-27-13 11:47 1 SALIVATION

 10-28-13 12:56 2 WET RED MATERIAL AROUND MOUTH

 10-28-13 12:56 3 SALIVATION

 10-29-13 12:29 3 WET CLEAR MATERIAL AROUND MOUTH

 10-29-13 12:29 3 SALIVATION

 10-30-13 12:28 1 SALIVATION

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 327 of 1107
 TABLE A2 (F0 MALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 14

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91605 M 10000 PPM ORAL/DENTAL 10-31-13 11:52 3 WET CLEAR MATERIAL AROUND MOUTH

 10-31-13 11:52 3 SALIVATION

 11-02-13 11:36 2 WET CLEAR MATERIAL AROUND MOUTH

 11-02-13 11:36 2 SALIVATION

 11-03-13 11:17 3 WET CLEAR MATERIAL AROUND MOUTH

 11-03-13 11:17 3 SALIVATION

 11-04-13 12:07 1 WET CLEAR MATERIAL AROUND MOUTH

 11-04-13 12:07 1 SALIVATION

 11-05-13 11:24 3 WET CLEAR MATERIAL AROUND MOUTH

 11-05-13 11:24 3 SALIVATION

 11-06-13 11:45 3 WET CLEAR MATERIAL AROUND MOUTH

 11-06-13 11:45 2 SALIVATION

 11-07-13 11:59 3 WET CLEAR MATERIAL AROUND MOUTH

 11-07-13 11:59 3 SALIVATION

 11-08-13 13:03 3 WET CLEAR MATERIAL AROUND MOUTH

 11-08-13 13:03 3 SALIVATION

 11-09-13 11:54 1 WET CLEAR MATERIAL AROUND MOUTH

 11-10-13 13:13 2 SALIVATION

 11-11-13 12:43 3 WET CLEAR MATERIAL AROUND MOUTH

 11-11-13 12:43 1 SALIVATION

 91612 M 10000 PPM NORMAL 10-24-13 13:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 11:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91612 M 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY

 91612 M 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION

 91612 M 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT

 10-14-13 13:26 P LACRIMATION

 91612 M 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION

 10-15-13 12:18 1 SALIVATION

 10-16-13 12:19 2 SALIVATION

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 328 of 1107
 TABLE A2 (F0 MALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 15

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91612 M 10000 PPM ORAL/DENTAL 10-16-13 12:19 2 WET CLEAR MATERIAL AROUND MOUTH

 10-17-13 11:54 2 SALIVATION

 10-18-13 11:47 2 SALIVATION

 10-18-13 11:47 1 WET CLEAR MATERIAL AROUND MOUTH

 10-19-13 11:25 2 SALIVATION

 10-19-13 11:25 2 WET CLEAR MATERIAL AROUND MOUTH

 10-20-13 11:19 2 SALIVATION

 10-21-13 12:34 1 SALIVATION

 10-22-13 12:02 2 SALIVATION

 10-23-13 11:45 2 SALIVATION

 10-23-13 11:45 2 WET CLEAR MATERIAL AROUND MOUTH

 10-25-13 14:11 1 SALIVATION

 10-26-13 11:54 1 SALIVATION

 10-27-13 11:47 1 SALIVATION

 10-28-13 12:57 3 WET CLEAR MATERIAL AROUND MOUTH

 10-28-13 12:57 3 SALIVATION

 10-29-13 12:29 3 WET CLEAR MATERIAL AROUND MOUTH

 10-29-13 12:29 3 SALIVATION

 10-30-13 12:28 2 SALIVATION

 10-31-13 11:52 3 WET CLEAR MATERIAL AROUND MOUTH

 10-31-13 11:52 3 SALIVATION

 11-01-13 11:39 3 WET CLEAR MATERIAL AROUND MOUTH

 11-01-13 11:39 3 SALIVATION

 11-02-13 11:36 2 WET CLEAR MATERIAL AROUND MOUTH

 11-02-13 11:37 2 SALIVATION

 11-03-13 11:17 3 WET CLEAR MATERIAL AROUND MOUTH

 11-03-13 11:17 3 SALIVATION

 11-04-13 12:07 3 WET CLEAR MATERIAL AROUND MOUTH

 11-04-13 12:07 3 SALIVATION

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 329 of 1107
 TABLE A2 (F0 MALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91612 M 10000 PPM ORAL/DENTAL 11-06-13 11:45 3 WET CLEAR MATERIAL AROUND MOUTH

 11-06-13 11:45 2 SALIVATION

 11-07-13 11:59 3 WET CLEAR MATERIAL AROUND MOUTH

 11-07-13 11:59 3 SALIVATION

 11-08-13 13:03 3 WET CLEAR MATERIAL AROUND MOUTH

 11-08-13 13:03 3 SALIVATION

 11-09-13 11:53 2 SALIVATION

 11-10-13 13:13 2 SALIVATION

 11-11-13 12:44 3 WET CLEAR MATERIAL AROUND MOUTH

 11-11-13 12:44 3 SALIVATION

 91618 M 10000 PPM NORMAL 10-16-13 12:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 11:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 13:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 11:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 11:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91618 M 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY

 91618 M 10000 PPM BODY/INTEGUMENT 10-21-13 12:35 1 WET CLEAR MATERIAL RIGHT FORELIMB

 10-21-13 12:35 1 WET CLEAR MATERIAL LEFT FORELIMB

 91618 M 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION

 91618 M 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT

 10-14-13 13:26 P LACRIMATION

 10-28-13 12:56 3 WET RED MATERIAL AROUND NOSE

 91618 M 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION

 10-15-13 12:18 1 SALIVATION

 10-17-13 11:54 1 WET CLEAR MATERIAL AROUND MOUTH

 10-18-13 11:46 2 SALIVATION

 10-18-13 11:46 1 WET CLEAR MATERIAL AROUND MOUTH

 10-19-13 11:25 1 SALIVATION

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 330 of 1107
 TABLE A2 (F0 MALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91618 M 10000 PPM ORAL/DENTAL 10-20-13 11:19 1 SALIVATION

 10-20-13 11:19 1 WET CLEAR MATERIAL AROUND MOUTH

 10-21-13 12:34 1 SALIVATION

 10-25-13 14:11 1 WET CLEAR MATERIAL AROUND MOUTH

 10-28-13 12:56 2 SALIVATION

 10-29-13 12:29 2 WET CLEAR MATERIAL AROUND MOUTH

 10-29-13 12:29 2 SALIVATION

 10-30-13 12:28 1 WET CLEAR MATERIAL AROUND MOUTH

 10-31-13 11:52 3 WET CLEAR MATERIAL AROUND MOUTH

 10-31-13 11:52 3 SALIVATION

 11-01-13 11:39 3 WET CLEAR MATERIAL AROUND MOUTH

 11-01-13 11:39 3 SALIVATION

 11-02-13 11:36 3 WET CLEAR MATERIAL AROUND MOUTH

 11-02-13 11:36 2 SALIVATION

 11-03-13 11:17 3 WET CLEAR MATERIAL AROUND MOUTH

 11-03-13 11:17 2 SALIVATION

 11-04-13 12:07 3 WET CLEAR MATERIAL AROUND MOUTH

 11-04-13 12:07 3 SALIVATION

 11-05-13 11:24 3 WET CLEAR MATERIAL AROUND MOUTH

 11-05-13 11:24 3 SALIVATION

 11-06-13 11:45 3 WET CLEAR MATERIAL AROUND MOUTH

 11-06-13 11:45 2 SALIVATION

 11-07-13 11:59 3 WET CLEAR MATERIAL AROUND MOUTH

 11-07-13 11:59 3 SALIVATION

 11-08-13 13:03 2 WET CLEAR MATERIAL AROUND MOUTH

 11-09-13 11:54 2 WET CLEAR MATERIAL AROUND MOUTH

 11-10-13 13:13 2 SALIVATION

 11-11-13 12:44 3 WET CLEAR MATERIAL AROUND MOUTH

 91619 M 10000 PPM NORMAL 10-15-13 12:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 331 of 1107
 TABLE A2 (F0 MALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

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 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91619 M 10000 PPM NORMAL 10-17-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91619 M 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY

 91619 M 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION

 91619 M 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT

 10-14-13 13:26 P LACRIMATION

 10-18-13 11:44 2 DRIED RED MATERIAL AROUND NOSE

 10-19-13 11:24 1 WET RED MATERIAL AROUND NOSE

 10-20-13 11:20 1 WET RED MATERIAL AROUND NOSE

 10-21-13 12:37 1 WET RED MATERIAL AROUND NOSE

 10-23-13 11:47 2 WET RED MATERIAL AROUND NOSE

 91619 M 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION

 10-16-13 12:17 1 WET RED MATERIAL AROUND MOUTH

 10-18-13 11:44 2 WET RED MATERIAL AROUND MOUTH

 10-19-13 11:23 1 SALIVATION

 10-19-13 11:23 1 WET RED MATERIAL AROUND MOUTH

 10-20-13 11:20 1 WET RED MATERIAL AROUND MOUTH

 10-20-13 11:20 1 SALIVATION

 10-21-13 12:37 1 WET RED MATERIAL AROUND MOUTH

 10-21-13 12:37 1 SALIVATION

 10-22-13 12:03 1 SALIVATION

 10-23-13 11:47 1 SALIVATION

 10-23-13 11:48 1 WET RED MATERIAL AROUND MOUTH

 10-24-13 13:40 1 SALIVATION

 10-25-13 14:12 1 SALIVATION

 10-26-13 11:53 1 SALIVATION

 10-27-13 11:48 1 SALIVATION

 10-28-13 12:55 3 WET CLEAR MATERIAL AROUND MOUTH

 10-28-13 12:55 2 SALIVATION

 10-29-13 12:28 3 WET CLEAR MATERIAL AROUND MOUTH

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 332 of 1107
 TABLE A2 (F0 MALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91619 M 10000 PPM ORAL/DENTAL 10-29-13 12:28 3 SALIVATION

 10-30-13 12:27 1 WET CLEAR MATERIAL AROUND MOUTH

 10-31-13 11:51 3 WET CLEAR MATERIAL AROUND MOUTH

 10-31-13 11:51 3 SALIVATION

 11-01-13 11:38 3 WET CLEAR MATERIAL AROUND MOUTH

 11-01-13 11:38 3 SALIVATION

 11-02-13 11:35 3 WET CLEAR MATERIAL AROUND MOUTH

 11-02-13 11:35 3 SALIVATION

 11-03-13 11:16 3 WET CLEAR MATERIAL AROUND MOUTH

 11-03-13 11:16 3 SALIVATION

 11-04-13 12:06 3 WET CLEAR MATERIAL AROUND MOUTH

 11-04-13 12:06 3 SALIVATION

 11-05-13 11:23 3 WET CLEAR MATERIAL AROUND MOUTH

 11-05-13 11:23 3 SALIVATION

 11-06-13 11:44 3 WET CLEAR MATERIAL AROUND MOUTH

 11-06-13 11:44 3 SALIVATION

 11-07-13 11:59 3 WET CLEAR MATERIAL AROUND MOUTH

 11-07-13 11:59 3 SALIVATION

 11-08-13 13:03 3 WET CLEAR MATERIAL AROUND MOUTH

 11-08-13 13:03 3 SALIVATION

 11-09-13 11:55 1 SALIVATION

 11-10-13 13:12 1 SALIVATION

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

 PCRDv4.18

 11/25/2013

 R:01/20/2014

Page 333 of 1107
 TABLE A3 (F0 MALES - 1 HOUR POST-EXPOSURE - GROUP 5)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91554 M 10000 PPM NORMAL 10-15-13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 13:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 12:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 11:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 11:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 13:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 13:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 12:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 12:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 13:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 13:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 13:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 12:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 12:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 12:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 13:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 12:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 13:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91554 M 10000 PPM ORAL/DENTAL 10-14-13 14:11 2 SALIVATION

 10-14-13 14:12 2 WET CLEAR MATERIAL AROUND MOUTH

 10-23-13 12:16 1 WET CLEAR MATERIAL AROUND MOUTH

 11-04-13 12:38 2 WET CLEAR MATERIAL AROUND MOUTH

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 334 of 1107
 TABLE A3 (F0 MALES - 1 HOUR POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91557 M 10000 PPM NORMAL 10-15-13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 13:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 12:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 12:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 11:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 11:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 13:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 12:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 12:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 13:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 13:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 13:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 12:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 12:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 12:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 12:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 12:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 13:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 12:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 13:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91557 M 10000 PPM EYES/EARS/NOSE 10-25-13 14:51 2 DRIED RED MATERIAL AROUND LEFT EYE

 10-26-13 12:31 1 DRIED RED MATERIAL AROUND LEFT EYE

 91557 M 10000 PPM ORAL/DENTAL 10-14-13 14:11 1 WET CLEAR MATERIAL AROUND MOUTH

 91558 M 10000 PPM NORMAL 10-15-13 13:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 335 of 1107
 TABLE A3 (F0 MALES - 1 HOUR POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91558 M 10000 PPM NORMAL 10-16-13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 12:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 12:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 12:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 13:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 12:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 12:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 13:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91558 M 10000 PPM EYES/EARS/NOSE 10-25-13 14:51 2 DRIED RED MATERIAL AROUND NOSE

 10-28-13 13:38 2 WET RED MATERIAL AROUND NOSE

 10-29-13 13:06 2 WET RED MATERIAL AROUND NOSE

 11-06-13 12:20 2 DRIED RED MATERIAL AROUND NOSE

 11-07-13 12:35 2 DRIED RED MATERIAL AROUND NOSE

 11-09-13 12:34 1 DRIED RED MATERIAL AROUND NOSE

 91558 M 10000 PPM ORAL/DENTAL 10-14-13 14:14 2 WET CLEAR MATERIAL AROUND MOUTH

 10-19-13 11:56 1 WET RED MATERIAL AROUND MOUTH

 10-20-13 11:54 1 WET RED MATERIAL AROUND MOUTH

 10-21-13 13:10 1 DRIED RED MATERIAL AROUND MOUTH

 10-23-13 12:18 1 WET RED MATERIAL AROUND MOUTH

 10-24-13 14:14 1 WET RED MATERIAL AROUND MOUTH

 10-28-13 13:38 3 WET CLEAR MATERIAL AROUND MOUTH

 10-29-13 13:06 2 WET RED MATERIAL AROUND MOUTH

 10-31-13 12:33 1 WET CLEAR MATERIAL AROUND MOUTH

 11-02-13 12:14 2 WET CLEAR MATERIAL AROUND MOUTH

 11-04-13 12:40 1 WET CLEAR MATERIAL AROUND MOUTH

 11-05-13 11:58 1 WET CLEAR MATERIAL AROUND MOUTH

 11-06-13 12:20 1 DRIED RED MATERIAL AROUND MOUTH

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 336 of 1107
 TABLE A3 (F0 MALES - 1 HOUR POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91558 M 10000 PPM ORAL/DENTAL 11-09-13 12:34 1 WET RED MATERIAL AROUND MOUTH

 11-10-13 13:51 1 WET RED MATERIAL AROUND MOUTH

 91571 M 10000 PPM NORMAL 10-15-13 13:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 13:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 12:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 12:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 11:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 11:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 13:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 13:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 12:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 12:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 12:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 13:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 13:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 12:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 12:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 12:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 12:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 13:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 12:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 13:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 13:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91571 M 10000 PPM EYES/EARS/NOSE 10-25-13 14:52 3 DRIED RED MATERIAL AROUND NOSE

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 337 of 1107
 TABLE A3 (F0 MALES - 1 HOUR POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91571 M 10000 PPM EYES/EARS/NOSE 10-29-13 13:02 2 DRIED RED MATERIAL AROUND NOSE

 91571 M 10000 PPM ORAL/DENTAL 10-14-13 14:12 1 WET CLEAR MATERIAL AROUND MOUTH

 91575 M 10000 PPM NORMAL 10-15-13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 13:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 12:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 12:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 11:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 11:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 13:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 12:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 12:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 13:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 13:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 13:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 12:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 12:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 12:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 13:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 12:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91575 M 10000 PPM EYES/EARS/NOSE 10-14-13 14:09 1 DRIED RED MATERIAL AROUND NOSE

 11-10-13 13:49 1 WET RED MATERIAL AROUND NOSE

 91575 M 10000 PPM ORAL/DENTAL 11-03-13 12:00 2 WET RED MATERIAL AROUND MOUTH

 11-04-13 12:39 1 WET CLEAR MATERIAL AROUND MOUTH

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 338 of 1107
 TABLE A3 (F0 MALES - 1 HOUR POST-EXPOSURE - GROUP 5)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91575 M 10000 PPM ORAL/DENTAL 11-06-13 12:19 2 WET CLEAR MATERIAL AROUND MOUTH

 11-10-13 13:49 1 WET RED MATERIAL AROUND MOUTH

 91600 M 10000 PPM NORMAL 10-14-13 14:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 13:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 12:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 11:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 13:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 12:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 12:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 13:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 13:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 13:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 12:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91600 M 10000 PPM EYES/EARS/NOSE 10-23-13 12:16 1 WET RED MATERIAL AROUND NOSE

 11-09-13 12:32 1 WET RED MATERIAL AROUND NOSE

 11-10-13 13:50 1 WET RED MATERIAL AROUND NOSE

 91600 M 10000 PPM ORAL/DENTAL 10-19-13 11:54 1 WET CLEAR MATERIAL AROUND MOUTH

 10-21-13 13:07 1 DRIED RED MATERIAL AROUND MOUTH

 10-23-13 12:16 1 WET RED MATERIAL AROUND MOUTH

 11-02-13 12:12 1 WET RED MATERIAL AROUND MOUTH

 11-03-13 11:59 1 WET CLEAR MATERIAL AROUND MOUTH

 11-04-13 12:38 1 WET CLEAR MATERIAL AROUND MOUTH

 11-05-13 11:57 1 WET CLEAR MATERIAL AROUND MOUTH

 11-06-13 12:19 2 WET CLEAR MATERIAL AROUND MOUTH

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

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 TABLE A3 (F0 MALES - 1 HOUR POST-EXPOSURE - GROUP 5)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91600 M 10000 PPM ORAL/DENTAL 11-07-13 12:33 2 WET CLEAR MATERIAL AROUND MOUTH

 11-08-13 13:38 2 WET CLEAR MATERIAL AROUND MOUTH

 11-09-13 12:32 1 WET RED MATERIAL AROUND MOUTH

 11-10-13 13:50 1 WET RED MATERIAL AROUND MOUTH

 11-11-13 13:18 2 WET CLEAR MATERIAL AROUND MOUTH

 91603 M 10000 PPM NORMAL 10-14-13 14:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 13:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 12:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 12:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 11:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 11:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 13:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 12:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 12:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 12:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 13:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 13:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 13:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 12:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 12:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 12:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 12:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 340 of 1107
 TABLE A3 (F0 MALES - 1 HOUR POST-EXPOSURE - GROUP 5)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91603 M 10000 PPM NORMAL 11-07-13 12:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 13:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 12:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 13:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 13:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91604 M 10000 PPM NORMAL 10-14-13 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 13:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 12:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 12:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 11:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 11:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 13:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 12:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 12:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 13:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 12:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 12:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91604 M 10000 PPM EYES/EARS/NOSE 10-28-13 13:37 3 DRIED RED MATERIAL AROUND NOSE

 10-29-13 13:04 2 WET RED MATERIAL AROUND NOSE

 11-05-13 11:58 1 WET RED MATERIAL AROUND NOSE

 11-06-13 12:20 2 DRIED RED MATERIAL AROUND NOSE

 11-10-13 13:51 1 DRIED RED MATERIAL AROUND NOSE

 91604 M 10000 PPM ORAL/DENTAL 10-23-13 12:19 1 WET RED MATERIAL AROUND MOUTH

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 341 of 1107
 TABLE A3 (F0 MALES - 1 HOUR POST-EXPOSURE - GROUP 5)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91604 M 10000 PPM ORAL/DENTAL 10-28-13 13:37 1 DRIED RED MATERIAL AROUND MOUTH

 10-29-13 13:04 2 WET RED MATERIAL AROUND MOUTH

 11-03-13 12:00 1 WET CLEAR MATERIAL AROUND MOUTH

 11-04-13 12:40 1 WET CLEAR MATERIAL AROUND MOUTH

 11-05-13 11:58 2 WET CLEAR MATERIAL AROUND MOUTH

 11-07-13 12:34 2 WET CLEAR MATERIAL AROUND MOUTH

 11-08-13 13:39 2 WET CLEAR MATERIAL AROUND MOUTH

 11-10-13 13:51 1 DRIED RED MATERIAL AROUND MOUTH

 91605 M 10000 PPM NORMAL 10-15-13 13:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 12:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 11:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 13:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 12:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 12:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 13:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 13:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 12:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 12:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 12:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 12:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 342 of 1107
 TABLE A3 (F0 MALES - 1 HOUR POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91605 M 10000 PPM NORMAL 11-05-13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 12:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 13:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 12:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 13:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 13:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91605 M 10000 PPM ORAL/DENTAL 10-14-13 14:14 1 WET CLEAR MATERIAL AROUND MOUTH

 91612 M 10000 PPM NORMAL 10-15-13 13:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 12:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 12:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 13:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 13:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 12:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 13:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 12:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 12:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 12:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 12:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91612 M 10000 PPM EYES/EARS/NOSE 11-10-13 13:50 1 WET RED MATERIAL AROUND NOSE

 91612 M 10000 PPM ORAL/DENTAL 10-14-13 14:13 2 WET CLEAR MATERIAL AROUND MOUTH

 10-14-13 14:13 1 SALIVATION

 10-19-13 11:57 1 WET RED MATERIAL AROUND MOUTH

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 343 of 1107
 TABLE A3 (F0 MALES - 1 HOUR POST-EXPOSURE - GROUP 5)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91612 M 10000 PPM ORAL/DENTAL 10-20-13 11:53 1 WET RED MATERIAL AROUND MOUTH

 10-23-13 12:17 1 WET RED MATERIAL AROUND MOUTH

 10-24-13 14:13 2 WET CLEAR MATERIAL AROUND MOUTH

 10-28-13 13:38 1 WET RED MATERIAL AROUND MOUTH

 10-29-13 13:06 3 WET CLEAR MATERIAL AROUND MOUTH

 10-31-13 12:34 1 WET CLEAR MATERIAL AROUND MOUTH

 11-04-13 12:40 1 WET CLEAR MATERIAL AROUND MOUTH

 11-08-13 13:40 2 WET CLEAR MATERIAL AROUND MOUTH

 11-10-13 13:50 1 WET RED MATERIAL AROUND MOUTH

 11-11-13 13:19 2 WET CLEAR MATERIAL AROUND MOUTH

 91618 M 10000 PPM NORMAL 10-15-13 13:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 12:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 11:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 13:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 12:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 12:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 13:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 13:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 12:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 12:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 344 of 1107
 TABLE A3 (F0 MALES - 1 HOUR POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 12

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91618 M 10000 PPM NORMAL 11-04-13 12:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 12:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 13:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 12:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 13:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 13:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91618 M 10000 PPM ORAL/DENTAL 10-14-13 14:13 2 WET CLEAR MATERIAL AROUND MOUTH

 11-01-13 12:13 2 WET CLEAR MATERIAL AROUND MOUTH

 91619 M 10000 PPM NORMAL 10-14-13 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 13:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 12:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 12:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 11:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 11:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 13:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 12:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 13:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 12:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91619 M 10000 PPM EYES/EARS/NOSE 10-23-13 12:19 1 DRIED RED MATERIAL AROUND NOSE

 10-25-13 14:53 3 DRIED RED MATERIAL AROUND NOSE

 10-29-13 13:05 2 DRIED RED MATERIAL AROUND NOSE

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 345 of 1107
 TABLE A3 (F0 MALES - 1 HOUR POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 13

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91619 M 10000 PPM EYES/EARS/NOSE 11-07-13 12:35 2 DRIED RED MATERIAL AROUND NOSE

 11-10-13 13:51 1 WET RED MATERIAL AROUND NOSE

 91619 M 10000 PPM ORAL/DENTAL 10-23-13 12:19 1 DRIED RED MATERIAL AROUND MOUTH

 10-28-13 13:37 1 DRIED RED MATERIAL AROUND MOUTH

 10-29-13 13:05 1 DRIED RED MATERIAL AROUND MOUTH

 11-01-13 12:13 1 WET RED MATERIAL AROUND MOUTH

 11-04-13 12:40 1 WET CLEAR MATERIAL AROUND MOUTH

 11-05-13 11:58 1 WET CLEAR MATERIAL AROUND MOUTH

 11-06-13 12:20 1 WET CLEAR MATERIAL AROUND MOUTH

 11-07-13 12:35 2 WET RED MATERIAL AROUND MOUTH

 11-08-13 13:39 2 WET CLEAR MATERIAL AROUND MOUTH

 11-09-13 12:34 1 WET RED MATERIAL AROUND MOUTH

 11-10-13 13:51 1 WET RED MATERIAL AROUND MOUTH

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

 PCRDv4.18

 11/25/2013

 R:01/20/2014

Page 346 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91555 M 0 PPM NORMAL 10-14-13 17:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 347 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91560 M 0 PPM NORMAL 10-14-13 17:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 348 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91562 M 0 PPM NORMAL 10-14-13 17:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91563 M 0 PPM NORMAL 10-17-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 349 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91563 M 0 PPM NORMAL 10-18-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91563 M 0 PPM EYES/EARS/NOSE 10-14-13 17:09 1 DRIED RED MATERIAL AROUND NOSE

 10-15-13 15:40 2 DRIED RED MATERIAL AROUND NOSE

 10-16-13 15:21 1 DRIED RED MATERIAL AROUND NOSE

 10-21-13 15:58 1 DRIED RED MATERIAL AROUND NOSE

 10-23-13 15:06 2 DRIED RED MATERIAL AROUND NOSE

 10-24-13 14:56 1 DRIED RED MATERIAL AROUND NOSE

 10-25-13 15:19 1 DRIED RED MATERIAL AROUND NOSE

 10-29-13 15:40 1 DRIED RED MATERIAL AROUND NOSE

 91564 M 0 PPM NORMAL 10-14-13 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 350 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91564 M 0 PPM NORMAL 10-16-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91567 M 0 PPM NORMAL 10-14-13 17:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 351 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91567 M 0 PPM NORMAL 10-16-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91579 M 0 PPM NORMAL 10-14-13 17:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 352 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91579 M 0 PPM NORMAL 10-17-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91586 M 0 PPM NORMAL 10-16-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 353 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91586 M 0 PPM NORMAL 10-19-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91586 M 0 PPM EYES/EARS/NOSE 10-14-13 17:10 3 DRIED RED MATERIAL AROUND NOSE

 10-15-13 15:41 1 DRIED RED MATERIAL AROUND NOSE

 10-20-13 14:44 1 DRIED RED MATERIAL AROUND NOSE

 10-22-13 15:19 1 DRIED RED MATERIAL AROUND NOSE

 11-08-13 14:57 1 DRIED RED MATERIAL AROUND NOSE

 91591 M 0 PPM NORMAL 10-14-13 17:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 354 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91591 M 0 PPM NORMAL 10-18-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91592 M 0 PPM NORMAL 10-14-13 17:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 355 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91592 M 0 PPM NORMAL 10-20-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91592 M 0 PPM EYES/EARS/NOSE 10-15-13 15:41 1 DRIED RED MATERIAL AROUND NOSE

 91609 M 0 PPM NORMAL 10-14-13 17:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 356 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 11

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91609 M 0 PPM NORMAL 10-19-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91615 M 0 PPM NORMAL 10-14-13 17:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 357 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 12

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91615 M 0 PPM NORMAL 10-20-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91615 M 0 PPM EYES/EARS/NOSE 10-18-13 15:11 1 DRIED RED MATERIAL AROUND NOSE

 91556 M 50 PPM NORMAL 10-14-13 17:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 358 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91556 M 50 PPM NORMAL 10-20-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91559 M 50 PPM NORMAL 10-14-13 17:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 359 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91559 M 50 PPM NORMAL 10-20-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91559 M 50 PPM EYES/EARS/NOSE 10-21-13 15:59 1 DRIED RED MATERIAL AROUND NOSE

 10-25-13 15:21 1 DRIED RED MATERIAL AROUND NOSE

 91561 M 50 PPM NORMAL 10-14-13 17:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 360 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91561 M 50 PPM NORMAL 10-21-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91561 M 50 PPM EYES/EARS/NOSE 10-18-13 15:11 1 DRIED RED MATERIAL AROUND NOSE

 91561 M 50 PPM ORAL/DENTAL 10-18-13 15:12 1 WET RED MATERIAL AROUND MOUTH

 91566 M 50 PPM NORMAL 10-15-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 361 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 16

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91566 M 50 PPM NORMAL 10-21-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91566 M 50 PPM EYES/EARS/NOSE 10-14-13 17:13 1 DRIED RED MATERIAL AROUND NOSE

 10-23-13 15:11 1 DRIED RED MATERIAL AROUND NOSE

 11-02-13 14:55 1 DRIED RED MATERIAL AROUND NOSE

 11-09-13 15:09 1 DRIED RED MATERIAL AROUND NOSE

 91576 M 50 PPM NORMAL 10-14-13 17:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 362 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91576 M 50 PPM NORMAL 10-21-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91576 M 50 PPM EYES/EARS/NOSE 10-22-13 15:21 1 DRIED RED MATERIAL AROUND NOSE

 11-01-13 15:03 1 DRIED RED MATERIAL AROUND NOSE

 91582 M 50 PPM NORMAL 10-14-13 17:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 363 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91582 M 50 PPM NORMAL 10-23-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91582 M 50 PPM EYES/EARS/NOSE 10-21-13 16:00 1 DRIED RED MATERIAL AROUND NOSE

 10-25-13 15:21 1 DRIED RED MATERIAL AROUND NOSE

 10-29-13 15:43 1 DRIED RED MATERIAL AROUND NOSE

 11-02-13 14:55 1 DRIED RED MATERIAL AROUND NOSE

 91585 M 50 PPM NORMAL 10-15-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 364 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 19

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91585 M 50 PPM NORMAL 10-25-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91585 M 50 PPM EYES/EARS/NOSE 10-14-13 17:14 1 DRIED RED MATERIAL AROUND NOSE

 10-18-13 15:13 2 DRIED RED MATERIAL AROUND NOSE

 10-22-13 15:21 1 DRIED RED MATERIAL AROUND NOSE

 91589 M 50 PPM NORMAL 10-14-13 17:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 365 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 20

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91589 M 50 PPM NORMAL 10-22-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91589 M 50 PPM EYES/EARS/NOSE 10-29-13 15:44 1 DRIED RED MATERIAL AROUND NOSE

 91593 M 50 PPM NORMAL 10-14-13 17:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 366 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91593 M 50 PPM NORMAL 10-25-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91593 M 50 PPM EYES/EARS/NOSE 10-22-13 15:22 1 DRIED RED MATERIAL AROUND NOSE

 10-24-13 14:59 1 DRIED RED MATERIAL AROUND NOSE

 11-05-13 14:38 1 DRIED RED MATERIAL AROUND NOSE

 91594 M 50 PPM NORMAL 10-14-13 17:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 367 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91594 M 50 PPM NORMAL 10-29-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91594 M 50 PPM EYES/EARS/NOSE 10-18-13 15:14 2 DRIED RED MATERIAL AROUND NOSE

 10-20-13 14:47 1 DRIED RED MATERIAL AROUND NOSE

 10-21-13 16:01 1 DRIED RED MATERIAL AROUND NOSE

 10-24-13 14:59 1 DRIED RED MATERIAL AROUND NOSE

 10-25-13 15:22 1 DRIED RED MATERIAL AROUND NOSE

 91595 M 50 PPM NORMAL 10-14-13 17:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 368 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 23

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91595 M 50 PPM NORMAL 10-25-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91595 M 50 PPM EYES/EARS/NOSE 11-06-13 14:54 1 DRIED RED MATERIAL AROUND NOSE

 11-08-13 14:59 1 DRIED RED MATERIAL AROUND NOSE

 91602 M 50 PPM NORMAL 10-14-13 17:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 369 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 24

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91602 M 50 PPM NORMAL 10-26-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91602 M 50 PPM EYES/EARS/NOSE 10-21-13 16:01 2 DRIED RED MATERIAL AROUND NOSE

 91569 M 100 PPM NORMAL 10-14-13 17:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 370 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 25

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91569 M 100 PPM NORMAL 10-25-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91573 M 100 PPM NORMAL 10-14-13 17:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 371 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 26

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91573 M 100 PPM NORMAL 10-30-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91573 M 100 PPM EYES/EARS/NOSE 10-18-13 15:15 1 DRIED RED MATERIAL AROUND NOSE

 10-20-13 14:49 1 DRIED RED MATERIAL AROUND NOSE

 10-22-13 15:23 2 DRIED RED MATERIAL AROUND NOSE

 10-24-13 15:00 2 DRIED RED MATERIAL AROUND NOSE

 10-25-13 15:24 1 DRIED RED MATERIAL AROUND LEFT EYE

 10-25-13 15:24 1 DRIED RED MATERIAL AROUND RIGHT EYE

 10-25-13 15:24 2 WET RED MATERIAL AROUND NOSE

 11-09-13 15:12 1 DRIED RED MATERIAL AROUND LEFT EYE

 11-09-13 15:12 1 DRIED RED MATERIAL AROUND RIGHT EYE

 11-10-13 17:03 1 DRIED RED MATERIAL AROUND LEFT EYE

 11-10-13 17:03 1 DRIED RED MATERIAL AROUND RIGHT EYE

 91577 M 100 PPM NORMAL 10-14-13 17:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 372 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 27

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91577 M 100 PPM NORMAL 10-22-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91581 M 100 PPM NORMAL 10-14-13 17:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 373 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 28

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91581 M 100 PPM NORMAL 10-23-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91581 M 100 PPM EYES/EARS/NOSE 10-15-13 15:45 1 DRIED RED MATERIAL AROUND NOSE

 91583 M 100 PPM NORMAL 10-14-13 17:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 374 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 29

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91583 M 100 PPM NORMAL 10-23-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91588 M 100 PPM NORMAL 10-14-13 17:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 375 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 30

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91588 M 100 PPM NORMAL 10-25-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91588 M 100 PPM EYES/EARS/NOSE 10-23-13 15:14 1 DRIED RED MATERIAL AROUND NOSE

 91590 M 100 PPM NORMAL 10-14-13 17:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 376 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 31

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91590 M 100 PPM NORMAL 10-25-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91590 M 100 PPM EYES/EARS/NOSE 10-18-13 15:16 1 DRIED RED MATERIAL AROUND NOSE

 91598 M 100 PPM NORMAL 10-14-13 17:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 377 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91598 M 100 PPM NORMAL 10-27-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91598 M 100 PPM EYES/EARS/NOSE 10-23-13 15:14 2 DRIED RED MATERIAL AROUND NOSE

 10-24-13 15:01 1 DRIED RED MATERIAL AROUND NOSE

 11-04-13 15:22 1 DRIED RED MATERIAL AROUND NOSE

 91599 M 100 PPM NORMAL 10-14-13 17:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 378 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91599 M 100 PPM NORMAL 10-25-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91608 M 100 PPM NORMAL 10-14-13 17:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 379 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91608 M 100 PPM NORMAL 10-26-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91611 M 100 PPM NORMAL 10-14-13 17:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 380 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91611 M 100 PPM NORMAL 10-30-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91611 M 100 PPM EYES/EARS/NOSE 10-22-13 15:24 1 DRIED RED MATERIAL AROUND NOSE

 10-23-13 15:14 1 DRIED RED MATERIAL AROUND NOSE

 10-24-13 15:01 1 DRIED RED MATERIAL AROUND NOSE

 10-29-13 15:47 1 DRIED RED MATERIAL AROUND NOSE

 91616 M 100 PPM NORMAL 10-15-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 381 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91616 M 100 PPM NORMAL 10-28-13 16:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91616 M 100 PPM EYES/EARS/NOSE 10-14-13 17:19 1 DRIED RED MATERIAL AROUND NOSE

 91565 M 175 PPM NORMAL 10-14-13 17:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 382 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91565 M 175 PPM NORMAL 10-28-13 16:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91565 M 175 PPM EYES/EARS/NOSE 10-24-13 15:02 1 DRIED RED MATERIAL AROUND NOSE

 11-02-13 14:58 1 DRIED RED MATERIAL AROUND NOSE

 91568 M 175 PPM NORMAL 10-14-13 17:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 383 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91568 M 175 PPM NORMAL 10-27-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91568 M 175 PPM EYES/EARS/NOSE 11-02-13 14:58 1 DRIED RED MATERIAL AROUND NOSE

 91570 M 175 PPM NORMAL 10-14-13 17:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 384 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91570 M 175 PPM NORMAL 10-28-13 16:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91572 M 175 PPM NORMAL 10-14-13 17:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 385 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91572 M 175 PPM NORMAL 11-02-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91572 M 175 PPM EYES/EARS/NOSE 10-21-13 16:06 3 DRIED RED MATERIAL AROUND NOSE

 10-22-13 15:25 2 DRIED RED MATERIAL AROUND NOSE

 10-24-13 15:02 1 DRIED RED MATERIAL AROUND NOSE

 11-01-13 15:07 1 DRIED RED MATERIAL AROUND NOSE

 91580 M 175 PPM NORMAL 10-14-13 17:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

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 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91580 M 175 PPM NORMAL 11-02-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91580 M 175 PPM EYES/EARS/NOSE 10-20-13 14:51 1 DRIED RED MATERIAL AROUND NOSE

 10-24-13 15:02 2 DRIED RED MATERIAL AROUND NOSE

 10-25-13 15:26 1 DRIED RED MATERIAL AROUND NOSE

 10-29-13 15:48 1 DRIED RED MATERIAL AROUND NOSE

 91584 M 175 PPM NORMAL 10-15-13 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 387 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91584 M 175 PPM NORMAL 10-30-13 15:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91584 M 175 PPM EYES/EARS/NOSE 10-14-13 17:21 1 DRIED RED MATERIAL AROUND NOSE

 91587 M 175 PPM NORMAL 10-15-13 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 388 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91587 M 175 PPM NORMAL 11-04-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91587 M 175 PPM EYES/EARS/NOSE 10-14-13 17:21 1 DRIED RED MATERIAL AROUND NOSE

 10-24-13 15:03 1 DRIED RED MATERIAL AROUND NOSE

 10-25-13 15:27 1 DRIED RED MATERIAL AROUND NOSE

 91587 M 175 PPM ORAL/DENTAL 10-18-13 15:19 1 WET RED MATERIAL AROUND MOUTH

 10-20-13 14:51 1 DRIED RED MATERIAL AROUND MOUTH

 10-24-13 15:03 1 WET CLEAR MATERIAL AROUND MOUTH

 91597 M 175 PPM NORMAL 10-14-13 17:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 389 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91597 M 175 PPM NORMAL 10-31-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91597 M 175 PPM EYES/EARS/NOSE 10-25-13 15:27 1 DRIED RED MATERIAL AROUND NOSE

 91601 M 175 PPM NORMAL 10-14-13 17:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

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 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91601 M 175 PPM NORMAL 10-31-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91601 M 175 PPM EYES/EARS/NOSE 10-21-13 16:07 1 DRIED RED MATERIAL AROUND NOSE

 91607 M 175 PPM NORMAL 10-14-13 17:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 391 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91607 M 175 PPM NORMAL 11-02-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91607 M 175 PPM EYES/EARS/NOSE 10-23-13 15:20 1 DRIED RED MATERIAL AROUND NOSE

 10-24-13 15:04 1 DRIED RED MATERIAL AROUND NOSE

 91613 M 175 PPM NORMAL 10-14-13 17:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 392 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91613 M 175 PPM NORMAL 11-03-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91613 M 175 PPM EYES/EARS/NOSE 10-18-13 15:19 1 DRIED RED MATERIAL AROUND NOSE

 10-20-13 14:52 1 DRIED RED MATERIAL AROUND NOSE

 91614 M 175 PPM NORMAL 10-14-13 17:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 393 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91614 M 175 PPM NORMAL 11-02-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91614 M 175 PPM ORAL/DENTAL 10-28-13 16:57 1 WET CLEAR MATERIAL AROUND MOUTH

 91554 M 10000 PPM NORMAL 10-14-13 17:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 394 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91554 M 10000 PPM NORMAL 11-01-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91557 M 10000 PPM NORMAL 10-14-13 17:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 395 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91557 M 10000 PPM NORMAL 11-04-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91557 M 10000 PPM EYES/EARS/NOSE 10-25-13 15:28 1 DRIED RED MATERIAL AROUND LEFT EYE

 10-25-13 15:28 1 DRIED RED MATERIAL AROUND RIGHT EYE

 10-26-13 14:54 1 DRIED RED MATERIAL AROUND LEFT EYE

 91558 M 10000 PPM NORMAL 10-14-13 17:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 396 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91558 M 10000 PPM NORMAL 11-04-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91558 M 10000 PPM EYES/EARS/NOSE 10-24-13 15:05 2 DRIED RED MATERIAL AROUND NOSE

 10-29-13 15:51 1 DRIED RED MATERIAL AROUND NOSE

 91571 M 10000 PPM NORMAL 10-14-13 17:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 397 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91571 M 10000 PPM NORMAL 11-06-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91571 M 10000 PPM EYES/EARS/NOSE 10-22-13 15:27 1 DRIED RED MATERIAL AROUND NOSE

 10-23-13 15:21 1 DRIED RED MATERIAL AROUND NOSE

 10-29-13 15:51 1 DRIED RED MATERIAL AROUND NOSE

 91575 M 10000 PPM NORMAL 10-14-13 17:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 398 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 53

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91575 M 10000 PPM NORMAL 11-03-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91600 M 10000 PPM NORMAL 10-14-13 17:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 399 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 54

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91600 M 10000 PPM NORMAL 11-05-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91600 M 10000 PPM EYES/EARS/NOSE 10-18-13 15:22 1 DRIED RED MATERIAL AROUND NOSE

 91603 M 10000 PPM NORMAL 10-14-13 17:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 400 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 55

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91603 M 10000 PPM NORMAL 11-04-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91604 M 10000 PPM NORMAL 10-14-13 17:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 401 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 56

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91604 M 10000 PPM NORMAL 11-04-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91605 M 10000 PPM NORMAL 10-14-13 17:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 402 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 57

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91605 M 10000 PPM NORMAL 11-05-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91612 M 10000 PPM NORMAL 10-14-13 17:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 403 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 58

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91612 M 10000 PPM NORMAL 11-05-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91618 M 10000 PPM NORMAL 10-14-13 17:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 404 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 59

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91618 M 10000 PPM NORMAL 11-06-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91618 M 10000 PPM EYES/EARS/NOSE 10-20-13 14:58 1 DRIED RED MATERIAL AROUND NOSE

 91619 M 10000 PPM NORMAL 10-14-13 17:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 405 of 1107
 TABLE A4 (F0 MALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 60

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-11-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91619 M 10000 PPM NORMAL 11-05-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

 PCRDv4.18

 11/25/2013

 R:01/20/2014

Page 406 of 1107
 TABLE A5 (F0 FEMALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-05-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91629 F 0 PPM NORMAL 10-14-13 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91629 F 0 PPM DISPOSITION 11-25-13 8:52 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91629 F 0 PPM BODY/INTEGUMENT 10-21-13 6:34 1 HAIR LOSS RIGHT FORELIMB

 10-21-13 6:34 1 HAIR LOSS LEFT FORELIMB

 10-27-13 6:19 1 HAIR LOSS RIGHT FORELIMB

 10-27-13 6:19 1 HAIR LOSS LEFT FORELIMB

 11-04-13 7:21 1 HAIR LOSS RIGHT FORELIMB

 11-04-13 7:21 1 HAIR LOSS LEFT FORELIMB

 11-10-13 7:22 1 HAIR LOSS RIGHT FORELIMB

 11-10-13 7:22 1 HAIR LOSS LEFT FORELIMB

 11-18-13 7:50 1 HAIR LOSS RIGHT FORELIMB

 11-18-13 7:50 2 HAIR LOSS LEFT FORELIMB

 11-25-13 7:37 2 HAIR LOSS RIGHT FORELIMB

 11-25-13 7:37 2 HAIR LOSS LEFT FORELIMB

 91630 F 0 PPM NORMAL 10-14-13 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-25-13 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-26-13 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91630 F 0 PPM DISPOSITION 11-26-13 8:40 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91633 F 0 PPM NORMAL 10-14-13 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 407 of 1107
 TABLE A5 (F0 FEMALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-05-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91633 F 0 PPM DISPOSITION 11-23-13 10:44 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91637 F 0 PPM NORMAL 10-14-13 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 8:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91637 F 0 PPM DISPOSITION 11-22-13 8:51 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91637 F 0 PPM BODY/INTEGUMENT 11-10-13 7:25 1 HAIR LOSS RIGHT INGUINAL AREA

 11-10-13 7:25 2 HAIR LOSS VENTRAL ABDOMINAL AREA

 11-18-13 7:51 3 HAIR LOSS VENTRAL ABDOMINAL AREA

 11-19-13 9:19 2 HAIR LOSS VENTRAL ABDOMINAL AREA

 91639 F 0 PPM NORMAL 10-14-13 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-25-13 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91639 F 0 PPM DISPOSITION 11-25-13 8:52 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91644 F 0 PPM NORMAL 10-14-13 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91644 F 0 PPM DISPOSITION 11-23-13 10:45 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91645 F 0 PPM NORMAL 10-14-13 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 408 of 1107
 TABLE A5 (F0 FEMALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-05-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91645 F 0 PPM NORMAL 11-04-13 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91645 F 0 PPM DISPOSITION 11-26-13 8:41 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91645 F 0 PPM BODY/INTEGUMENT 11-18-13 7:52 2 HAIR LOSS VENTRAL ABDOMINAL AREA

 11-25-13 7:43 1 HAIR LOSS VENTRAL ABDOMINAL AREA

 11-26-13 7:15 2 HAIR LOSS VENTRAL ABDOMINAL AREA

 11-26-13 7:15 1 HAIR LOSS RIGHT FORELIMB

 91648 F 0 PPM NORMAL 10-14-13 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 8:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91648 F 0 PPM DISPOSITION 11-23-13 10:45 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91653 F 0 PPM NORMAL 10-14-13 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-25-13 7:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91653 F 0 PPM DISPOSITION 11-25-13 8:52 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91660 F 0 PPM NORMAL 10-14-13 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 409 of 1107
 TABLE A5 (F0 FEMALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-05-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91660 F 0 PPM NORMAL 11-25-13 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91660 F 0 PPM DISPOSITION 11-25-13 8:52 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91670 F 0 PPM NORMAL 10-14-13 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91670 F 0 PPM DISPOSITION 11-26-13 8:41 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91670 F 0 PPM BODY/INTEGUMENT 11-10-13 7:28 1 HAIR LOSS RIGHT FORELIMB

 11-18-13 7:53 2 HAIR LOSS RIGHT FORELIMB

 11-18-13 7:53 2 HAIR LOSS LEFT FORELIMB

 11-25-13 7:46 1 HAIR LOSS LEFT FORELIMB

 11-25-13 7:46 2 HAIR LOSS RIGHT FORELIMB

 11-26-13 7:16 3 HAIR LOSS RIGHT FORELIMB

 11-26-13 7:16 1 HAIR LOSS LEFT FORELIMB

 91672 F 0 PPM NORMAL 10-14-13 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-25-13 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-26-13 7:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91672 F 0 PPM DISPOSITION 11-26-13 8:42 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91632 F 50 PPM NORMAL 10-14-13 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 410 of 1107
 TABLE A5 (F0 FEMALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-05-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91632 F 50 PPM NORMAL 11-25-13 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-27-13 7:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91632 F 50 PPM DISPOSITION 11-27-13 8:26 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91640 F 50 PPM NORMAL 10-14-13 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-25-13 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-27-13 7:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91640 F 50 PPM DISPOSITION 11-27-13 8:26 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91642 F 50 PPM NORMAL 10-14-13 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-24-13 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91642 F 50 PPM DISPOSITION 11-24-13 9:00 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91642 F 50 PPM EYES/EARS/NOSE 11-10-13 7:29 1 DRIED RED MATERIAL AROUND NOSE

 91647 F 50 PPM NORMAL 10-14-13 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-25-13 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-26-13 7:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91647 F 50 PPM DISPOSITION 11-26-13 8:43 P SCHEDULED EUTHANASIA; LACTATION DAY 4

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 411 of 1107
 TABLE A5 (F0 FEMALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-05-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91651 F 50 PPM NORMAL 10-14-13 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-25-13 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91651 F 50 PPM DISPOSITION 11-25-13 8:52 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91659 F 50 PPM NORMAL 10-14-13 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-24-13 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91659 F 50 PPM DISPOSITION 11-24-13 9:00 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91661 F 50 PPM NORMAL 10-14-13 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 8:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91661 F 50 PPM DISPOSITION 11-23-13 10:45 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91663 F 50 PPM NORMAL 10-14-13 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 412 of 1107
 TABLE A5 (F0 FEMALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-05-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91663 F 50 PPM NORMAL 11-18-13 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-25-13 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91663 F 50 PPM DISPOSITION 11-25-13 8:53 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91669 F 50 PPM NORMAL 10-14-13 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 8:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91669 F 50 PPM DISPOSITION 11-23-13 10:45 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91669 F 50 PPM BODY/INTEGUMENT 11-18-13 7:56 3 HAIR LOSS RIGHT FORELIMB

 11-18-13 7:56 2 HAIR LOSS LEFT FORELIMB

 91673 F 50 PPM NORMAL 10-21-13 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-25-13 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91673 F 50 PPM DISPOSITION 11-26-13 8:43 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91673 F 50 PPM BODY/INTEGUMENT 10-14-13 7:41 1 HAIR LOSS LEFT FORELIMB

 11-10-13 7:31 1 HAIR LOSS RIGHT FORELIMB

 11-26-13 7:18 1 HAIR LOSS RIGHT FORELIMB

 11-26-13 7:18 2 HAIR LOSS LEFT FORELIMB

 91683 F 50 PPM NORMAL 10-14-13 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-25-13 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 413 of 1107
 TABLE A5 (F0 FEMALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-05-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91683 F 50 PPM NORMAL 11-27-13 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91683 F 50 PPM DISPOSITION 11-27-13 8:26 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91685 F 50 PPM NORMAL 10-14-13 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 8:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91685 F 50 PPM DISPOSITION 11-23-13 10:46 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91620 F 100 PPM NORMAL 10-14-13 7:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91620 F 100 PPM DISPOSITION 11-26-13 8:44 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91620 F 100 PPM BODY/INTEGUMENT 11-18-13 7:58 1 HAIR LOSS RIGHT FORELIMB

 11-18-13 7:58 1 HAIR LOSS LEFT FORELIMB

 11-25-13 7:52 2 HAIR LOSS RIGHT FORELIMB

 11-25-13 7:52 1 HAIR LOSS LEFT FORELIMB

 11-26-13 7:20 1 HAIR LOSS RIGHT FORELIMB

 11-26-13 7:20 1 HAIR LOSS LEFT FORELIMB

 91628 F 100 PPM NORMAL 10-14-13 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-24-13 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

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 TABLE A5 (F0 FEMALES - DETAILED PHYSICAL EXAMINATIONS)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-05-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91628 F 100 PPM DISPOSITION 11-24-13 9:00 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91631 F 100 PPM NORMAL 10-14-13 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-24-13 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91631 F 100 PPM DISPOSITION 11-24-13 9:00 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91631 F 100 PPM BODY/INTEGUMENT 11-18-13 7:59 1 HAIR LOSS RIGHT FORELIMB

 11-18-13 7:59 1 HAIR LOSS LEFT FORELIMB

 91636 F 100 PPM NORMAL 10-14-13 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-25-13 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91636 F 100 PPM DISPOSITION 11-25-13 8:53 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91649 F 100 PPM NORMAL 10-14-13 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 8:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 8:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91649 F 100 PPM DISPOSITION 11-23-13 10:46 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91650 F 100 PPM NORMAL 10-14-13 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 415 of 1107
 TABLE A5 (F0 FEMALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-05-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91650 F 100 PPM NORMAL 10-28-13 8:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 8:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91650 F 100 PPM DISPOSITION 11-23-13 10:46 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91656 F 100 PPM NORMAL 10-14-13 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 8:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91656 F 100 PPM DISPOSITION 11-28-13 8:36 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91656 F 100 PPM BODY/INTEGUMENT 11-25-13 7:54 1 HAIR LOSS LEFT FORELIMB

 11-28-13 7:02 2 HAIR LOSS LEFT FORELIMB

 11-28-13 7:02 1 HAIR LOSS RIGHT FORELIMB

 91671 F 100 PPM NORMAL 10-14-13 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-25-13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-28-13 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91671 F 100 PPM DISPOSITION 11-28-13 8:37 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91675 F 100 PPM NORMAL 10-14-13 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 8:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 416 of 1107
 TABLE A5 (F0 FEMALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 11

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-05-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91675 F 100 PPM NORMAL 11-18-13 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-24-13 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91675 F 100 PPM DISPOSITION 11-24-13 9:00 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91675 F 100 PPM EYES/EARS/NOSE 11-10-13 7:34 1 DRIED RED MATERIAL AROUND NOSE

 91677 F 100 PPM NORMAL 10-14-13 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91677 F 100 PPM DISPOSITION 11-25-13 8:53 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91677 F 100 PPM BODY/INTEGUMENT 11-18-13 8:01 3 HAIR LOSS RIGHT FORELIMB

 11-18-13 8:01 3 HAIR LOSS LEFT FORELIMB

 11-25-13 7:56 3 HAIR LOSS RIGHT FORELIMB

 11-25-13 7:56 3 HAIR LOSS LEFT FORELIMB

 91679 F 100 PPM NORMAL 10-14-13 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 8:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91679 F 100 PPM DISPOSITION 11-23-13 10:47 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91684 F 100 PPM NORMAL 10-14-13 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-24-13 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 417 of 1107
 TABLE A5 (F0 FEMALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 12

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-05-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91684 F 100 PPM DISPOSITION 11-24-13 9:01 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91622 F 175 PPM NORMAL 10-14-13 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91622 F 175 PPM DISPOSITION 11-23-13 10:47 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91622 F 175 PPM BODY/INTEGUMENT 10-21-13 6:54 2 HAIR LOSS RIGHT FORELIMB

 10-21-13 6:54 2 HAIR LOSS LEFT FORELIMB

 10-27-13 6:30 1 HAIR LOSS RIGHT FORELIMB

 10-27-13 6:30 1 HAIR LOSS LEFT FORELIMB

 10-28-13 9:00 1 HAIR LOSS RIGHT FORELIMB

 10-28-13 9:00 1 HAIR LOSS LEFT FORELIMB

 11-04-13 7:32 1 HAIR LOSS RIGHT FORELIMB

 11-04-13 7:32 1 HAIR LOSS LEFT FORELIMB

 11-10-13 7:36 1 HAIR LOSS RIGHT FORELIMB

 11-10-13 7:36 1 HAIR LOSS LEFT FORELIMB

 11-18-13 8:03 3 HAIR LOSS RIGHT FORELIMB

 11-18-13 8:03 3 HAIR LOSS LEFT FORELIMB

 91623 F 175 PPM NORMAL 10-14-13 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 8:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-25-13 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 12-02-13 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 12-05-13 8:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91623 F 175 PPM DISPOSITION 12-05-13 8:59 P SCHEDULED EUTHANASIA; POST-COHABITATION DAY 25

 91623 F 175 PPM SPECIAL II 11-10-13 16:55 P BREEDING PERIOD COMPLETE; FEMALE SEPARATED FROM

 MALE AND PLACED INTO CLEAN CAGING

 91626 F 175 PPM NORMAL 10-14-13 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 418 of 1107
 TABLE A5 (F0 FEMALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 13

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-05-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91626 F 175 PPM NORMAL 10-27-13 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 8:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-25-13 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-26-13 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91626 F 175 PPM DISPOSITION 11-26-13 8:45 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91643 F 175 PPM NORMAL 10-14-13 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 8:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-25-13 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-29-13 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91643 F 175 PPM DISPOSITION 11-29-13 7:36 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91654 F 175 PPM NORMAL 10-14-13 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-25-13 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-27-13 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91654 F 175 PPM DISPOSITION 11-27-13 8:27 P SCHEDULED EUTHANASIA; TOTAL LITTER LOSS

 91657 F 175 PPM NORMAL 10-14-13 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 419 of 1107
 TABLE A5 (F0 FEMALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 14

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-05-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91657 F 175 PPM NORMAL 11-10-13 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-25-13 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 12-02-13 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 12-04-13 7:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91657 F 175 PPM DISPOSITION 12-04-13 10:01 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91662 F 175 PPM NORMAL 10-14-13 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-25-13 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-26-13 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91662 F 175 PPM DISPOSITION 11-26-13 8:46 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91666 F 175 PPM NORMAL 10-14-13 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 9:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-24-13 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91666 F 175 PPM DISPOSITION 11-24-13 9:01 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91676 F 175 PPM NORMAL 10-14-13 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 420 of 1107
 TABLE A5 (F0 FEMALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 15

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-05-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91676 F 175 PPM NORMAL 11-18-13 8:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-25-13 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91676 F 175 PPM DISPOSITION 11-25-13 8:53 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91678 F 175 PPM NORMAL 10-14-13 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 9:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 8:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-24-13 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91678 F 175 PPM DISPOSITION 11-24-13 9:01 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91681 F 175 PPM NORMAL 10-14-13 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 8:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-25-13 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 12-02-13 7:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 12-03-13 7:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91681 F 175 PPM DISPOSITION 12-03-13 8:43 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91681 F 175 PPM EYES/EARS/NOSE 11-10-13 7:38 1 DRIED RED MATERIAL AROUND NOSE

 91682 F 175 PPM NORMAL 10-14-13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91682 F 175 PPM DISPOSITION 11-26-13 8:46 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91682 F 175 PPM BODY/INTEGUMENT 11-18-13 8:06 2 HAIR LOSS RIGHT FORELIMB

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 421 of 1107
 TABLE A5 (F0 FEMALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 16

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-05-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91682 F 175 PPM BODY/INTEGUMENT 11-18-13 8:06 3 HAIR LOSS LEFT FORELIMB

 11-25-13 8:10 3 HAIR LOSS RIGHT FORELIMB

 11-25-13 8:10 3 HAIR LOSS LEFT FORELIMB

 11-26-13 7:25 3 HAIR LOSS RIGHT FORELIMB

 11-26-13 7:25 3 HAIR LOSS LEFT FORELIMB

 91624 F 10000 PPM NORMAL 10-14-13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 8:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-25-13 8:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91624 F 10000 PPM DISPOSITION 11-25-13 8:53 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91625 F 10000 PPM NORMAL 10-14-13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 8:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-25-13 8:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-26-13 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91625 F 10000 PPM DISPOSITION 11-26-13 8:47 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91627 F 10000 PPM NORMAL 10-14-13 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 9:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 8:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 422 of 1107
 TABLE A5 (F0 FEMALES - DETAILED PHYSICAL EXAMINATIONS)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-05-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91627 F 10000 PPM DISPOSITION 11-23-13 10:47 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91634 F 10000 PPM NORMAL 10-14-13 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 8:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-25-13 8:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-26-13 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91634 F 10000 PPM DISPOSITION 11-26-13 8:48 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91635 F 10000 PPM DISPOSITION 11-23-13 10:48 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91635 F 10000 PPM BODY/INTEGUMENT 10-14-13 7:56 1 HAIR LOSS RIGHT FORELIMB

 10-14-13 7:56 1 HAIR LOSS LEFT FORELIMB

 10-21-13 7:02 1 HAIR LOSS RIGHT FORELIMB

 10-21-13 7:02 1 HAIR LOSS LEFT FORELIMB

 10-27-13 6:34 1 HAIR LOSS RIGHT FORELIMB

 10-27-13 6:34 1 HAIR LOSS LEFT FORELIMB

 10-28-13 9:01 1 HAIR LOSS RIGHT FORELIMB

 10-28-13 9:01 1 HAIR LOSS LEFT FORELIMB

 11-04-13 7:36 1 HAIR LOSS RIGHT FORELIMB

 11-04-13 7:36 1 HAIR LOSS LEFT FORELIMB

 11-10-13 7:40 1 HAIR LOSS RIGHT FORELIMB

 11-10-13 7:40 1 HAIR LOSS LEFT FORELIMB

 11-18-13 8:08 3 HAIR LOSS RIGHT FORELIMB

 11-18-13 8:08 2 HAIR LOSS LEFT FORELIMB

 91638 F 10000 PPM NORMAL 10-14-13 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 423 of 1107
 TABLE A5 (F0 FEMALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 18

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-05-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91638 F 10000 PPM NORMAL 11-10-13 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 8:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91638 F 10000 PPM DISPOSITION 11-25-13 8:53 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91638 F 10000 PPM BODY/INTEGUMENT 11-25-13 8:15 1 HAIR LOSS LEFT FORELIMB

 91652 F 10000 PPM NORMAL 10-14-13 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91652 F 10000 PPM DISPOSITION 11-23-13 10:48 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91652 F 10000 PPM BODY/INTEGUMENT 10-21-13 7:03 2 HAIR LOSS RIGHT FORELIMB

 10-21-13 7:03 2 HAIR LOSS LEFT FORELIMB

 10-27-13 6:34 1 HAIR LOSS RIGHT FORELIMB

 10-27-13 6:34 1 HAIR LOSS LEFT FORELIMB

 10-28-13 9:02 1 HAIR LOSS RIGHT FORELIMB

 10-28-13 9:02 1 HAIR LOSS LEFT FORELIMB

 11-04-13 7:36 2 HAIR LOSS RIGHT FORELIMB

 11-04-13 7:36 1 HAIR LOSS LEFT FORELIMB

 11-10-13 7:41 2 HAIR LOSS RIGHT FORELIMB

 11-10-13 7:41 1 HAIR LOSS LEFT FORELIMB

 11-18-13 8:09 3 HAIR LOSS RIGHT FORELIMB

 11-18-13 8:09 3 HAIR LOSS LEFT FORELIMB

 91655 F 10000 PPM NORMAL 10-14-13 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91655 F 10000 PPM DISPOSITION 11-23-13 10:48 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91655 F 10000 PPM BODY/INTEGUMENT 10-21-13 7:05 1 HAIR LOSS VENTRAL ABDOMINAL AREA

 10-21-13 7:05 1 HAIR LOSS RIGHT INGUINAL AREA

 10-21-13 7:05 1 HAIR LOSS LEFT INGUINAL AREA

 10-21-13 7:05 1 HAIR LOSS LEFT HINDLIMB

 10-27-13 6:35 1 HAIR LOSS VENTRAL ABDOMINAL AREA

 10-27-13 6:35 1 HAIR LOSS RIGHT INGUINAL AREA

 10-27-13 6:35 1 HAIR LOSS LEFT INGUINAL AREA

 10-27-13 6:35 1 HAIR LOSS LEFT HINDLIMB

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 424 of 1107
 TABLE A5 (F0 FEMALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 19

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-05-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91655 F 10000 PPM BODY/INTEGUMENT 10-28-13 9:02 1 HAIR LOSS LEFT HINDLIMB

 10-28-13 9:02 1 HAIR LOSS VENTRAL ABDOMINAL AREA

 10-28-13 9:03 1 HAIR LOSS LEFT INGUINAL AREA

 10-28-13 9:03 1 HAIR LOSS RIGHT INGUINAL AREA

 11-04-13 7:37 1 HAIR LOSS RIGHT INGUINAL AREA

 11-04-13 7:37 1 HAIR LOSS LEFT INGUINAL AREA

 11-04-13 7:37 1 HAIR LOSS LEFT HINDLIMB

 11-04-13 7:37 1 HAIR LOSS RIGHT HINDLIMB

 11-04-13 7:37 1 HAIR LOSS VENTRAL ABDOMINAL AREA

 11-18-13 8:09 3 HAIR LOSS RIGHT HINDLIMB

 11-18-13 8:09 2 HAIR LOSS LEFT HINDLIMB

 11-18-13 8:10 2 HAIR LOSS VENTRAL ABDOMINAL AREA

 91658 F 10000 PPM NORMAL 10-14-13 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91658 F 10000 PPM DISPOSITION 11-24-13 9:01 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91658 F 10000 PPM BODY/INTEGUMENT 11-10-13 7:42 2 HAIR LOSS RIGHT FORELIMB

 11-10-13 7:42 2 HAIR LOSS LEFT FORELIMB

 11-18-13 8:10 3 HAIR LOSS RIGHT FORELIMB

 11-18-13 8:10 3 HAIR LOSS LEFT FORELIMB

 11-24-13 7:26 3 HAIR LOSS RIGHT FORELIMB

 11-24-13 7:26 3 HAIR LOSS LEFT FORELIMB

 11-24-13 7:26 2 HAIR LOSS RIGHT HINDLIMB

 91667 F 10000 PPM NORMAL 10-14-13 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 425 of 1107
 TABLE A5 (F0 FEMALES - DETAILED PHYSICAL EXAMINATIONS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 20

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-05-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91667 F 10000 PPM NORMAL 11-18-13 8:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-24-13 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91667 F 10000 PPM DISPOSITION 11-24-13 9:02 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91668 F 10000 PPM NORMAL 10-14-13 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91668 F 10000 PPM DISPOSITION 11-24-13 9:02 P SCHEDULED EUTHANASIA; LACTATION DAY 4

 91668 F 10000 PPM BODY/INTEGUMENT 10-21-13 7:06 1 HAIR LOSS RIGHT FORELIMB

 10-21-13 7:06 1 HAIR LOSS LEFT FORELIMB

 10-27-13 6:36 1 HAIR LOSS RIGHT FORELIMB

 10-27-13 6:36 1 HAIR LOSS LEFT FORELIMB

 11-04-13 7:38 1 HAIR LOSS RIGHT FORELIMB

 11-04-13 7:38 1 HAIR LOSS LEFT FORELIMB

 11-10-13 7:42 1 HAIR LOSS RIGHT FORELIMB

 11-10-13 7:42 1 HAIR LOSS LEFT FORELIMB

 11-18-13 8:11 3 HAIR LOSS RIGHT FORELIMB

 11-18-13 8:11 3 HAIR LOSS LEFT FORELIMB

 11-24-13 7:27 2 HAIR LOSS RIGHT FORELIMB

 11-24-13 7:27 2 HAIR LOSS LEFT FORELIMB

 91680 F 10000 PPM NORMAL 10-14-13 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 7:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 9:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 8:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91680 F 10000 PPM DISPOSITION 11-23-13 10:48 P SCHEDULED EUTHANASIA; LACTATION DAY 4

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

 PCRDv4.18

 01/29/2014

Page 426 of 1107
 TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91624 F 10000 PPM NORMAL 10-15-13 12:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 12:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 13:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91624 F 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY

 91624 F 10000 PPM BODY/INTEGUMENT 10-17-13 11:46 1 WET CLEAR MATERIAL RIGHT FORELIMB

 10-30-13 12:32 1 WET CLEAR MATERIAL RIGHT FORELIMB

 10-30-13 12:32 1 WET CLEAR MATERIAL LEFT FORELIMB

 10-30-13 12:32 1 WET CLEAR MATERIAL VENTRAL NECK

 91624 F 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION

 91624 F 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P LACRIMATION

 10-14-13 13:26 P EYELIDS COMPLETELY SHUT

 10-17-13 11:45 1 WET RED MATERIAL AROUND NOSE

 10-31-13 11:56 2 WET RED MATERIAL AROUND NOSE

 11-02-13 11:41 1 WET RED MATERIAL AROUND NOSE

 11-17-13 11:48 1 DRIED RED MATERIAL AROUND NOSE

 91624 F 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION

 10-17-13 11:45 1 SALIVATION

 10-17-13 11:45 1 WET CLEAR MATERIAL AROUND MOUTH

 10-18-13 11:52 2 WET CLEAR MATERIAL AROUND MOUTH

 10-19-13 11:29 2 SALIVATION

 10-19-13 11:29 1 WET CLEAR MATERIAL AROUND MOUTH

 10-20-13 11:23 2 SALIVATION

 10-20-13 11:23 2 WET CLEAR MATERIAL AROUND MOUTH

 10-21-13 12:42 1 SALIVATION

 10-22-13 11:58 1 SALIVATION

 10-23-13 11:53 2 SALIVATION

 10-23-13 11:53 3 WET CLEAR MATERIAL AROUND MOUTH

 10-24-13 13:43 1 SALIVATION

 10-25-13 14:14 1 SALIVATION

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 427 of 1107
 TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91624 F 10000 PPM ORAL/DENTAL 10-26-13 11:59 1 WET CLEAR MATERIAL AROUND MOUTH

 10-27-13 11:50 1 SALIVATION

 10-28-13 13:01 3 WET CLEAR MATERIAL AROUND MOUTH

 10-28-13 13:01 3 SALIVATION

 10-29-13 12:33 3 WET CLEAR MATERIAL AROUND MOUTH

 10-29-13 12:33 2 SALIVATION

 10-30-13 12:32 2 WET CLEAR MATERIAL AROUND MOUTH

 10-31-13 11:56 2 SALIVATION

 10-31-13 11:56 2 WET CLEAR MATERIAL AROUND MOUTH

 11-01-13 11:43 2 WET CLEAR MATERIAL AROUND MOUTH

 11-01-13 11:43 1 SALIVATION

 11-02-13 11:41 2 SALIVATION

 11-02-13 11:41 2 WET CLEAR MATERIAL AROUND MOUTH

 11-03-13 11:22 2 WET CLEAR MATERIAL AROUND MOUTH

 11-04-13 12:10 1 WET CLEAR MATERIAL AROUND MOUTH

 11-04-13 12:10 1 SALIVATION

 11-05-13 11:27 1 WET CLEAR MATERIAL AROUND MOUTH

 11-06-13 11:49 1 WET CLEAR MATERIAL AROUND MOUTH

 11-06-13 11:49 1 SALIVATION

 11-07-13 12:03 1 WET CLEAR MATERIAL AROUND MOUTH

 11-07-13 12:03 1 SALIVATION

 11-08-13 13:07 1 SALIVATION

 11-09-13 11:58 1 SALIVATION

 11-11-13 12:47 1 WET CLEAR MATERIAL AROUND MOUTH

 11-12-13 11:36 2 WET CLEAR MATERIAL AROUND MOUTH

 11-12-13 11:36 1 SALIVATION

 11-13-13 11:42 1 WET CLEAR MATERIAL AROUND MOUTH

 11-13-13 11:42 1 SALIVATION

 11-14-13 13:01 2 SALIVATION

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 428 of 1107
 TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91624 F 10000 PPM ORAL/DENTAL 11-14-13 13:01 2 WET CLEAR MATERIAL AROUND MOUTH

 11-15-13 12:00 2 WET CLEAR MATERIAL AROUND MOUTH

 11-15-13 12:00 2 SALIVATION

 11-16-13 11:44 P SALIVATION

 11-17-13 11:48 1 SALIVATION

 11-18-13 12:42 1 WET CLEAR MATERIAL AROUND MOUTH

 11-18-13 12:42 1 SALIVATION

 11-19-13 11:56 2 SALIVATION

 11-19-13 11:56 1 WET CLEAR MATERIAL AROUND MOUTH

 91625 F 10000 PPM NORMAL 10-22-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91625 F 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY

 91625 F 10000 PPM BODY/INTEGUMENT 10-21-13 12:40 1 WET CLEAR MATERIAL RIGHT FORELIMB

 10-21-13 12:40 1 WET CLEAR MATERIAL LEFT FORELIMB

 10-29-13 12:31 3 WET CLEAR MATERIAL VENTRAL NECK

 10-30-13 12:29 1 WET CLEAR MATERIAL RIGHT FORELIMB

 10-30-13 12:29 2 WET CLEAR MATERIAL LEFT FORELIMB

 10-30-13 12:29 2 WET CLEAR MATERIAL VENTRAL NECK

 11-05-13 11:25 3 WET CLEAR MATERIAL VENTRAL NECK

 11-05-13 11:25 3 WET CLEAR MATERIAL LEFT FORELIMB

 11-05-13 11:25 3 WET CLEAR MATERIAL RIGHT FORELIMB

 11-06-13 11:47 3 WET CLEAR MATERIAL VENTRAL NECK

 11-06-13 11:47 2 WET CLEAR MATERIAL LEFT FORELIMB

 11-06-13 11:47 2 WET CLEAR MATERIAL RIGHT FORELIMB

 11-07-13 12:01 3 WET CLEAR MATERIAL VENTRAL NECK

 11-07-13 12:01 3 WET CLEAR MATERIAL LEFT FORELIMB

 11-07-13 12:01 3 WET CLEAR MATERIAL RIGHT FORELIMB

 11-08-13 13:05 3 WET CLEAR MATERIAL VENTRAL NECK

 11-10-13 13:08 1 WET CLEAR MATERIAL LEFT FORELIMB

 11-10-13 13:08 1 WET CLEAR MATERIAL RIGHT FORELIMB

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 429 of 1107
 TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91625 F 10000 PPM BODY/INTEGUMENT 11-11-13 12:45 3 WET CLEAR MATERIAL VENTRAL NECK

 11-11-13 12:45 3 WET CLEAR MATERIAL LEFT FORELIMB

 11-11-13 12:45 3 WET CLEAR MATERIAL RIGHT FORELIMB

 11-12-13 11:33 3 WET CLEAR MATERIAL VENTRAL NECK

 11-12-13 11:34 3 WET CLEAR MATERIAL LEFT FORELIMB

 11-12-13 11:34 3 WET CLEAR MATERIAL RIGHT FORELIMB

 11-13-13 11:40 2 WET CLEAR MATERIAL VENTRAL NECK

 11-13-13 11:40 2 WET CLEAR MATERIAL LEFT FORELIMB

 11-13-13 11:40 2 WET CLEAR MATERIAL RIGHT FORELIMB

 11-14-13 12:59 2 WET CLEAR MATERIAL VENTRAL NECK

 11-15-13 11:58 3 WET CLEAR MATERIAL VENTRAL NECK

 11-15-13 11:58 2 WET CLEAR MATERIAL LEFT FORELIMB

 11-15-13 11:58 2 WET CLEAR MATERIAL RIGHT FORELIMB

 11-18-13 12:41 2 WET CLEAR MATERIAL VENTRAL NECK

 11-19-13 11:55 3 WET CLEAR MATERIAL VENTRAL NECK

 11-19-13 11:55 3 WET CLEAR MATERIAL RIGHT FORELIMB

 11-19-13 11:55 3 WET CLEAR MATERIAL LEFT FORELIMB

 91625 F 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION

 91625 F 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT

 10-14-13 13:26 P LACRIMATION

 10-17-13 11:43 1 WET RED MATERIAL AROUND NOSE

 10-18-13 11:50 3 WET RED MATERIAL AROUND NOSE

 10-20-13 11:22 1 LACRIMATION RIGHT EYE

 10-20-13 11:22 1 WET RED MATERIAL AROUND NOSE

 11-03-13 11:19 2 WET RED MATERIAL AROUND NOSE

 11-07-13 12:01 1 WET RED MATERIAL AROUND NOSE

 11-17-13 11:46 1 WET RED MATERIAL AROUND NOSE

 91625 F 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION

 10-15-13 12:29 1 WET CLEAR MATERIAL AROUND MOUTH

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 430 of 1107
 TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91625 F 10000 PPM ORAL/DENTAL 10-16-13 12:20 1 WET CLEAR MATERIAL AROUND MOUTH

 10-17-13 11:42 2 WET CLEAR MATERIAL AROUND MOUTH

 10-17-13 11:42 2 SALIVATION

 10-18-13 11:50 3 SALIVATION

 10-18-13 11:50 3 WET CLEAR MATERIAL AROUND MOUTH

 10-19-13 11:27 1 SALIVATION

 10-19-13 11:27 3 WET CLEAR MATERIAL AROUND MOUTH

 10-20-13 11:22 1 SALIVATION

 10-20-13 11:22 2 WET CLEAR MATERIAL AROUND MOUTH

 10-21-13 12:39 2 SALIVATION

 10-21-13 12:40 2 WET CLEAR MATERIAL AROUND MOUTH

 10-23-13 11:51 2 SALIVATION

 10-23-13 11:51 3 WET CLEAR MATERIAL AROUND MOUTH

 10-24-13 13:42 1 WET CLEAR MATERIAL AROUND MOUTH

 10-25-13 14:13 1 WET CLEAR MATERIAL AROUND MOUTH

 10-26-13 11:56 2 WET CLEAR MATERIAL AROUND MOUTH

 10-27-13 11:49 1 SALIVATION

 10-28-13 12:58 3 WET CLEAR MATERIAL AROUND MOUTH

 10-28-13 12:58 3 SALIVATION

 10-29-13 12:31 3 WET CLEAR MATERIAL AROUND MOUTH

 10-29-13 12:31 3 SALIVATION

 10-30-13 12:29 3 WET CLEAR MATERIAL AROUND MOUTH

 10-31-13 11:54 2 WET CLEAR MATERIAL AROUND MOUTH

 10-31-13 11:54 2 SALIVATION

 11-01-13 11:40 3 WET CLEAR MATERIAL AROUND MOUTH

 11-01-13 11:40 1 SALIVATION

 11-02-13 11:38 3 WET CLEAR MATERIAL AROUND MOUTH

 11-02-13 11:38 1 SALIVATION

 11-03-13 11:19 3 WET CLEAR MATERIAL AROUND MOUTH

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 431 of 1107
 TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91625 F 10000 PPM ORAL/DENTAL 11-03-13 11:19 2 SALIVATION

 11-04-13 12:08 3 WET CLEAR MATERIAL AROUND MOUTH

 11-04-13 12:08 2 SALIVATION

 11-05-13 11:25 3 WET CLEAR MATERIAL AROUND MOUTH

 11-05-13 11:25 1 SALIVATION

 11-06-13 11:47 3 WET CLEAR MATERIAL AROUND MOUTH

 11-06-13 11:47 3 SALIVATION

 11-07-13 12:01 3 WET CLEAR MATERIAL AROUND MOUTH

 11-07-13 12:01 2 SALIVATION

 11-08-13 13:05 3 WET CLEAR MATERIAL AROUND MOUTH

 11-08-13 13:05 3 SALIVATION

 11-09-13 11:56 2 SALIVATION

 11-10-13 13:08 2 SALIVATION

 11-10-13 13:08 2 WET CLEAR MATERIAL AROUND MOUTH

 11-11-13 12:45 3 WET CLEAR MATERIAL AROUND MOUTH

 11-11-13 12:45 3 SALIVATION

 11-12-13 11:34 3 WET CLEAR MATERIAL AROUND MOUTH

 11-13-13 11:40 3 WET CLEAR MATERIAL AROUND MOUTH

 11-14-13 12:59 3 WET CLEAR MATERIAL AROUND MOUTH

 11-14-13 12:59 1 SALIVATION

 11-15-13 11:58 3 WET CLEAR MATERIAL AROUND MOUTH

 11-15-13 11:58 1 SALIVATION

 11-16-13 11:42 2 WET CLEAR MATERIAL AROUND MOUTH

 11-17-13 11:46 2 WET CLEAR MATERIAL AROUND MOUTH

 11-18-13 12:41 3 WET CLEAR MATERIAL AROUND MOUTH

 11-18-13 12:41 3 SALIVATION

 11-19-13 11:55 3 WET CLEAR MATERIAL AROUND MOUTH

 11-19-13 11:55 2 SALIVATION

 91627 F 10000 PPM NORMAL 10-15-13 12:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 432 of 1107
 TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91627 F 10000 PPM NORMAL 10-16-13 12:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 11:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 11:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 11:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 11:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 12:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 13:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 11:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 13:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 11:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 11:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 11:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 12:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 11:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 11:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91627 F 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY

 91627 F 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION

 91627 F 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT

 10-14-13 13:26 P LACRIMATION

 91627 F 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION

 10-23-13 11:54 1 WET RED MATERIAL AROUND MOUTH

 10-30-13 12:31 1 WET CLEAR MATERIAL AROUND MOUTH

 11-03-13 11:21 2 WET CLEAR MATERIAL AROUND MOUTH

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 433 of 1107
 TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91627 F 10000 PPM ORAL/DENTAL 11-07-13 12:02 2 WET CLEAR MATERIAL AROUND MOUTH

 11-09-13 11:57 1 WET CLEAR MATERIAL AROUND MOUTH

 11-10-13 13:10 1 WET CLEAR MATERIAL AROUND MOUTH

 11-11-13 12:46 3 WET CLEAR MATERIAL AROUND MOUTH

 11-12-13 11:35 3 WET CLEAR MATERIAL AROUND MOUTH

 11-13-13 11:41 1 WET CLEAR MATERIAL AROUND MOUTH

 11-14-13 13:00 1 WET CLEAR MATERIAL AROUND MOUTH

 11-15-13 11:59 2 WET CLEAR MATERIAL AROUND MOUTH

 11-17-13 11:50 2 WET CLEAR MATERIAL AROUND MOUTH

 91634 F 10000 PPM NORMAL 10-15-13 12:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 11:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 11:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 12:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 12:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 13:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 12:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91634 F 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY

 91634 F 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION

 91634 F 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT

 10-14-13 13:26 P LACRIMATION

 10-18-13 11:48 1 DRIED RED MATERIAL AROUND NOSE

 11-17-13 11:51 1 WET RED MATERIAL AROUND NOSE

 91634 F 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION

 10-23-13 11:55 1 SALIVATION

 10-23-13 11:55 2 WET CLEAR MATERIAL AROUND MOUTH

 10-27-13 11:51 1 SALIVATION

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 434 of 1107
 TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91634 F 10000 PPM ORAL/DENTAL 10-28-13 12:59 2 SALIVATION

 10-28-13 12:59 2 WET CLEAR MATERIAL AROUND MOUTH

 10-29-13 12:32 3 WET CLEAR MATERIAL AROUND MOUTH

 10-29-13 12:32 2 SALIVATION

 10-31-13 11:54 2 WET CLEAR MATERIAL AROUND MOUTH

 11-01-13 11:41 1 WET CLEAR MATERIAL AROUND MOUTH

 11-01-13 11:41 1 SALIVATION

 11-02-13 11:39 3 WET CLEAR MATERIAL AROUND MOUTH

 11-03-13 11:21 1 WET CLEAR MATERIAL AROUND MOUTH

 11-04-13 12:09 1 WET CLEAR MATERIAL AROUND MOUTH

 11-05-13 11:26 2 WET CLEAR MATERIAL AROUND MOUTH

 11-06-13 11:48 1 WET RED MATERIAL AROUND MOUTH

 11-07-13 12:02 2 WET CLEAR MATERIAL AROUND MOUTH

 11-07-13 12:02 2 SALIVATION

 11-08-13 13:06 1 WET CLEAR MATERIAL AROUND MOUTH

 11-08-13 13:06 1 SALIVATION

 11-09-13 11:57 1 WET RED MATERIAL AROUND MOUTH

 11-10-13 13:09 1 SALIVATION

 11-11-13 12:46 2 WET CLEAR MATERIAL AROUND MOUTH

 11-11-13 12:46 1 SALIVATION

 11-12-13 11:35 2 WET CLEAR MATERIAL AROUND MOUTH

 11-13-13 11:41 2 WET CLEAR MATERIAL AROUND MOUTH

 11-14-13 13:00 1 WET CLEAR MATERIAL AROUND MOUTH

 11-15-13 11:59 1 WET CLEAR MATERIAL AROUND MOUTH

 11-16-13 11:46 1 WET CLEAR MATERIAL AROUND MOUTH

 11-17-13 11:51 1 WET CLEAR MATERIAL AROUND MOUTH

 11-18-13 12:42 1 SALIVATION

 11-18-13 12:42 1 WET CLEAR MATERIAL AROUND MOUTH

 11-19-13 11:55 2 WET CLEAR MATERIAL AROUND MOUTH

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 435 of 1107
 TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91634 F 10000 PPM ORAL/DENTAL 11-20-13 12:37 2 WET CLEAR MATERIAL AROUND MOUTH

 11-20-13 12:37 2 SALIVATION

 91635 F 10000 PPM NORMAL 10-15-13 12:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 12:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 11:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 11:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 11:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 11:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 12:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 13:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 14:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 11:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 12:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 11:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91635 F 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY

 91635 F 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION

 91635 F 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT

 10-14-13 13:26 P LACRIMATION

 11-01-13 11:41 2 WET RED MATERIAL AROUND NOSE

 91635 F 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION

 10-23-13 11:50 1 WET CLEAR MATERIAL AROUND MOUTH

 10-27-13 11:49 1 WET CLEAR MATERIAL AROUND MOUTH

 10-28-13 12:58 3 WET CLEAR MATERIAL AROUND MOUTH

 10-28-13 12:58 3 SALIVATION

 10-29-13 12:31 2 WET CLEAR MATERIAL AROUND MOUTH

 10-31-13 11:54 2 WET CLEAR MATERIAL AROUND MOUTH

 10-31-13 11:54 2 SALIVATION

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 436 of 1107
 TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 11

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91635 F 10000 PPM ORAL/DENTAL 11-03-13 11:19 3 WET CLEAR MATERIAL AROUND MOUTH

 11-03-13 11:19 1 SALIVATION

 11-04-13 12:08 2 WET CLEAR MATERIAL AROUND MOUTH

 11-04-13 12:08 1 SALIVATION

 11-05-13 11:26 3 WET CLEAR MATERIAL AROUND MOUTH

 11-06-13 11:47 2 WET CLEAR MATERIAL AROUND MOUTH

 11-06-13 11:47 2 SALIVATION

 11-07-13 12:01 2 WET CLEAR MATERIAL AROUND MOUTH

 11-07-13 12:01 2 SALIVATION

 11-08-13 13:05 3 WET CLEAR MATERIAL AROUND MOUTH

 11-09-13 11:56 1 SALIVATION

 11-10-13 13:08 1 SALIVATION

 11-11-13 12:45 3 WET CLEAR MATERIAL AROUND MOUTH

 11-11-13 12:45 2 SALIVATION

 11-12-13 11:34 3 WET CLEAR MATERIAL AROUND MOUTH

 11-13-13 11:40 3 WET CLEAR MATERIAL AROUND MOUTH

 11-14-13 12:59 3 WET CLEAR MATERIAL AROUND MOUTH

 11-16-13 11:42 1 WET CLEAR MATERIAL AROUND MOUTH

 11-17-13 11:45 1 SALIVATION

 91638 F 10000 PPM NORMAL 10-15-13 12:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 12:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 11:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 11:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 11:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 12:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 13:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 14:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 11:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 437 of 1107
 TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 12

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91638 F 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY

 91638 F 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION

 91638 F 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT

 10-14-13 13:26 P LACRIMATION

 10-28-13 12:59 2 DRIED RED MATERIAL AROUND NOSE

 10-29-13 12:31 2 DRIED RED MATERIAL AROUND NOSE

 11-06-13 11:48 1 WET RED MATERIAL AROUND NOSE

 11-10-13 13:07 1 WET RED MATERIAL AROUND NOSE

 11-17-13 11:45 1 DRIED RED MATERIAL AROUND NOSE

 91638 F 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION

 10-20-13 11:21 1 WET CLEAR MATERIAL AROUND MOUTH

 10-23-13 11:49 1 WET RED MATERIAL AROUND MOUTH

 10-27-13 11:49 1 WET CLEAR MATERIAL AROUND MOUTH

 10-28-13 12:59 1 SALIVATION

 10-28-13 12:59 1 WET CLEAR MATERIAL AROUND MOUTH

 10-30-13 12:29 1 WET CLEAR MATERIAL AROUND MOUTH

 10-31-13 11:54 2 WET CLEAR MATERIAL AROUND MOUTH

 10-31-13 11:54 2 SALIVATION

 11-01-13 11:41 2 WET CLEAR MATERIAL AROUND MOUTH

 11-01-13 11:41 1 SALIVATION

 11-02-13 11:38 2 WET CLEAR MATERIAL AROUND MOUTH

 11-02-13 11:39 1 SALIVATION

 11-03-13 11:19 1 WET CLEAR MATERIAL AROUND MOUTH

 11-04-13 12:09 2 WET CLEAR MATERIAL AROUND MOUTH

 11-04-13 12:09 1 SALIVATION

 11-05-13 11:26 3 WET CLEAR MATERIAL AROUND MOUTH

 11-06-13 11:48 2 WET CLEAR MATERIAL AROUND MOUTH

 11-06-13 11:48 1 SALIVATION

 11-07-13 12:01 1 WET CLEAR MATERIAL AROUND MOUTH

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 438 of 1107
 TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 13

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91638 F 10000 PPM ORAL/DENTAL 11-07-13 12:01 1 SALIVATION

 11-08-13 13:05 3 WET CLEAR MATERIAL AROUND MOUTH

 11-09-13 11:56 1 WET RED MATERIAL AROUND MOUTH

 11-11-13 12:46 3 WET CLEAR MATERIAL AROUND MOUTH

 11-12-13 11:34 3 WET CLEAR MATERIAL AROUND MOUTH

 11-13-13 11:40 3 WET CLEAR MATERIAL AROUND MOUTH

 11-13-13 11:40 1 SALIVATION

 11-14-13 12:59 2 WET CLEAR MATERIAL AROUND MOUTH

 11-15-13 11:58 2 WET CLEAR MATERIAL AROUND MOUTH

 11-15-13 11:58 1 SALIVATION

 11-16-13 11:42 1 WET CLEAR MATERIAL AROUND MOUTH

 11-17-13 11:45 2 SALIVATION

 11-18-13 12:41 2 WET CLEAR MATERIAL AROUND MOUTH

 11-18-13 12:41 1 SALIVATION

 11-19-13 11:55 3 WET CLEAR MATERIAL AROUND MOUTH

 11-19-13 11:55 3 SALIVATION

 91652 F 10000 PPM NORMAL 10-15-13 12:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 12:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 11:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 11:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 12:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 11:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 13:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 11:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 439 of 1107
 TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 14

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91652 F 10000 PPM NORMAL 10-30-13 12:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 11:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 12:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 11:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 11:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 13:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 11:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 11:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91652 F 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY

 91652 F 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION

 91652 F 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT

 10-14-13 13:26 P LACRIMATION

 91652 F 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION

 10-28-13 13:00 3 SALIVATION

 10-28-13 13:00 3 WET CLEAR MATERIAL AROUND MOUTH

 10-29-13 12:32 1 WET RED MATERIAL AROUND MOUTH

 11-01-13 11:42 1 WET CLEAR MATERIAL AROUND MOUTH

 11-02-13 11:40 2 WET CLEAR MATERIAL AROUND MOUTH

 11-03-13 11:21 2 WET CLEAR MATERIAL AROUND MOUTH

 11-05-13 11:26 1 WET CLEAR MATERIAL AROUND MOUTH

 11-08-13 13:06 1 WET CLEAR MATERIAL AROUND MOUTH

 11-09-13 11:57 1 WET RED MATERIAL AROUND MOUTH

 11-10-13 13:10 1 SALIVATION

 11-11-13 12:46 1 WET CLEAR MATERIAL AROUND MOUTH

 91655 F 10000 PPM NORMAL 10-15-13 12:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 12:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 440 of 1107
 TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 15

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91655 F 10000 PPM NORMAL 10-17-13 11:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 11:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 11:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 11:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 13:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 14:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 11:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 11:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 12:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 13:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 11:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 12:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91655 F 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY

 91655 F 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION

 91655 F 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT

 10-14-13 13:26 P LACRIMATION

 11-12-13 11:33 2 WET RED MATERIAL AROUND NOSE

 11-13-13 11:39 1 DRIED RED MATERIAL AROUND NOSE

 11-15-13 11:57 2 WET RED MATERIAL AROUND NOSE

 11-17-13 11:47 2 WET RED MATERIAL AROUND NOSE

 91655 F 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION

 10-28-13 12:58 3 SALIVATION

 10-28-13 12:58 3 WET CLEAR MATERIAL AROUND MOUTH

 10-29-13 12:30 1 WET RED MATERIAL AROUND MOUTH

 10-30-13 12:30 1 SALIVATION

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 441 of 1107
 TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 16

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91655 F 10000 PPM ORAL/DENTAL 10-31-13 11:53 2 WET CLEAR MATERIAL AROUND MOUTH

 10-31-13 11:53 2 SALIVATION

 11-01-13 11:40 2 WET CLEAR MATERIAL AROUND MOUTH

 11-01-13 11:40 1 SALIVATION

 11-03-13 11:18 1 WET RED MATERIAL AROUND MOUTH

 11-05-13 11:24 1 WET CLEAR MATERIAL AROUND MOUTH

 11-05-13 11:24 1 SALIVATION

 11-06-13 11:46 1 WET CLEAR MATERIAL AROUND MOUTH

 11-06-13 11:46 1 SALIVATION

 11-07-13 12:00 2 WET CLEAR MATERIAL AROUND MOUTH

 11-07-13 12:00 2 SALIVATION

 11-10-13 13:09 1 WET CLEAR MATERIAL AROUND MOUTH

 11-11-13 12:45 1 WET CLEAR MATERIAL AROUND MOUTH

 11-12-13 11:33 1 WET RED MATERIAL AROUND MOUTH

 11-15-13 11:57 2 WET RED MATERIAL AROUND MOUTH

 11-16-13 11:44 1 DRIED RED MATERIAL AROUND MOUTH

 11-17-13 11:47 1 WET CLEAR MATERIAL AROUND MOUTH

 91658 F 10000 PPM NORMAL 10-15-13 12:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 12:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 11:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 11:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 11:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 13:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 11:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 12:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 11:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 442 of 1107
 TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 17

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91658 F 10000 PPM NORMAL 11-06-13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91658 F 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY

 91658 F 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION

 91658 F 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT

 10-14-13 13:26 P LACRIMATION

 10-21-13 12:43 1 WET RED MATERIAL AROUND NOSE

 10-23-13 11:53 1 WET RED MATERIAL AROUND NOSE

 10-31-13 11:55 3 WET RED MATERIAL AROUND NOSE

 11-13-13 11:42 2 DRIED RED MATERIAL AROUND NOSE

 11-15-13 12:00 2 DRIED RED MATERIAL AROUND NOSE

 11-17-13 11:49 1 WET RED MATERIAL AROUND NOSE

 11-18-13 12:42 2 WET RED MATERIAL AROUND NOSE

 91658 F 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION

 10-20-13 11:24 2 WET CLEAR MATERIAL AROUND MOUTH

 10-23-13 11:54 1 WET RED MATERIAL AROUND MOUTH

 10-28-13 13:00 2 SALIVATION

 10-28-13 13:00 3 WET CLEAR MATERIAL AROUND MOUTH

 10-29-13 12:33 1 WET RED MATERIAL AROUND MOUTH

 10-30-13 12:31 2 WET CLEAR MATERIAL AROUND MOUTH

 10-31-13 11:55 2 WET RED MATERIAL AROUND MOUTH

 11-01-13 11:42 2 WET CLEAR MATERIAL AROUND MOUTH

 11-02-13 11:41 2 WET CLEAR MATERIAL AROUND MOUTH

 11-03-13 11:22 1 WET CLEAR MATERIAL AROUND MOUTH

 11-07-13 12:03 2 WET CLEAR MATERIAL AROUND MOUTH

 11-08-13 13:07 1 WET CLEAR MATERIAL AROUND MOUTH

 11-09-13 11:57 1 WET RED MATERIAL AROUND MOUTH

 11-10-13 13:10 1 WET CLEAR MATERIAL AROUND MOUTH

 11-11-13 12:47 2 WET CLEAR MATERIAL AROUND MOUTH

 11-12-13 11:35 1 WET CLEAR MATERIAL AROUND MOUTH

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 443 of 1107
 TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 18

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91658 F 10000 PPM ORAL/DENTAL 11-13-13 11:42 2 DRIED RED MATERIAL AROUND MOUTH

 11-14-13 13:01 1 WET CLEAR MATERIAL AROUND MOUTH

 11-16-13 11:45 1 DRIED RED MATERIAL AROUND MOUTH

 11-17-13 11:49 1 WET CLEAR MATERIAL AROUND MOUTH

 11-18-13 12:42 2 WET RED MATERIAL AROUND MOUTH

 91667 F 10000 PPM NORMAL 10-15-13 12:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 11:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 11:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 11:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 11:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 13:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 14:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 11:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 12:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 12:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 11:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 12:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 11:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 11:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 13:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 13:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 11:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 12:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 444 of 1107
 TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 19

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91667 F 10000 PPM NORMAL 11-15-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 11:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91667 F 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY

 91667 F 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION

 91667 F 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT

 10-14-13 13:26 P LACRIMATION

 10-18-13 11:48 1 WET RED MATERIAL AROUND NOSE

 10-28-13 12:57 1 DRIED RED MATERIAL AROUND NOSE

 11-18-13 12:40 1 WET RED MATERIAL AROUND NOSE

 91667 F 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION

 10-31-13 11:53 1 WET CLEAR MATERIAL AROUND MOUTH

 11-01-13 11:39 3 WET CLEAR MATERIAL AROUND MOUTH

 11-01-13 11:39 2 SALIVATION

 11-03-13 11:18 1 WET CLEAR MATERIAL AROUND MOUTH

 11-07-13 12:00 2 WET CLEAR MATERIAL AROUND MOUTH

 11-07-13 12:00 2 SALIVATION

 11-11-13 12:44 2 WET CLEAR MATERIAL AROUND MOUTH

 11-17-13 11:48 1 WET CLEAR MATERIAL AROUND MOUTH

 91668 F 10000 PPM NORMAL 10-15-13 12:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 12:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 11:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 11:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 11:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 13:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 11:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 445 of 1107
 TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 20

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91668 F 10000 PPM NORMAL 10-30-13 12:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91668 F 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY

 91668 F 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION

 91668 F 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT

 10-14-13 13:26 P LACRIMATION

 10-17-13 11:43 1 DRIED RED MATERIAL AROUND NOSE

 11-06-13 11:46 1 WET RED MATERIAL AROUND NOSE

 11-13-13 11:40 1 DRIED RED MATERIAL AROUND NOSE

 91668 F 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION

 10-25-13 14:14 1 SALIVATION

 10-28-13 12:58 3 WET CLEAR MATERIAL AROUND MOUTH

 10-28-13 12:58 3 SALIVATION

 10-29-13 12:30 3 WET CLEAR MATERIAL AROUND MOUTH

 10-29-13 12:30 3 SALIVATION

 10-31-13 11:53 2 WET CLEAR MATERIAL AROUND MOUTH

 10-31-13 11:54 2 SALIVATION

 11-01-13 11:40 3 WET CLEAR MATERIAL AROUND MOUTH

 11-01-13 11:40 3 SALIVATION

 11-02-13 11:38 2 WET CLEAR MATERIAL AROUND MOUTH

 11-02-13 11:38 1 SALIVATION

 11-03-13 11:18 3 WET CLEAR MATERIAL AROUND MOUTH

 11-03-13 11:18 3 SALIVATION

 11-04-13 12:08 2 WET CLEAR MATERIAL AROUND MOUTH

 11-05-13 11:24 2 WET CLEAR MATERIAL AROUND MOUTH

 11-05-13 11:25 2 SALIVATION

 11-06-13 11:46 2 WET CLEAR MATERIAL AROUND MOUTH

 11-06-13 11:46 1 SALIVATION

 11-07-13 12:00 3 WET CLEAR MATERIAL AROUND MOUTH

 11-07-13 12:00 3 SALIVATION

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 446 of 1107
 TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 21

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91668 F 10000 PPM ORAL/DENTAL 11-08-13 13:04 1 WET CLEAR MATERIAL AROUND MOUTH

 11-08-13 13:04 2 SALIVATION

 11-09-13 11:56 1 DRIED RED MATERIAL AROUND MOUTH

 11-10-13 13:09 2 SALIVATION

 11-11-13 12:45 3 WET CLEAR MATERIAL AROUND MOUTH

 11-11-13 12:45 2 SALIVATION

 11-12-13 11:33 1 WET CLEAR MATERIAL AROUND MOUTH

 11-13-13 11:40 1 DRIED RED MATERIAL AROUND MOUTH

 11-14-13 12:58 1 SALIVATION

 11-15-13 11:58 1 WET CLEAR MATERIAL AROUND MOUTH

 11-16-13 11:43 1 DRIED RED MATERIAL AROUND MOUTH

 11-17-13 11:47 2 SALIVATION

 11-18-13 12:40 2 SALIVATION

 11-18-13 12:40 2 WET CLEAR MATERIAL AROUND MOUTH

 91680 F 10000 PPM NORMAL 10-15-13 12:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 12:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 11:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 11:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 13:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 11:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 11:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 11:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 11:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 12:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 11:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 447 of 1107
 TABLE A6 (F0 FEMALES - 15 MINUTES POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 22

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91680 F 10000 PPM NORMAL 11-07-13 12:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 13:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 11:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 11:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 13:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 12:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 11:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91680 F 10000 PPM BEHAVIOR/CNS 10-14-13 13:26 P HYPOACTIVITY

 91680 F 10000 PPM CARDIO-PULMONARY 10-14-13 13:26 P DECREASED RESPIRATION

 91680 F 10000 PPM EYES/EARS/NOSE 10-14-13 13:26 P EYELIDS COMPLETELY SHUT

 10-14-13 13:26 P LACRIMATION

 10-21-13 12:42 1 WET RED MATERIAL AROUND NOSE

 11-01-13 11:43 1 WET RED MATERIAL AROUND NOSE

 91680 F 10000 PPM ORAL/DENTAL 10-14-13 13:26 P SALIVATION

 10-17-13 11:46 1 WET CLEAR MATERIAL AROUND MOUTH

 10-20-13 11:24 2 SALIVATION

 10-28-13 13:00 2 WET CLEAR MATERIAL AROUND MOUTH

 10-29-13 12:33 1 WET RED MATERIAL AROUND MOUTH

 10-30-13 12:32 1 SALIVATION

 11-01-13 11:43 2 WET RED MATERIAL AROUND MOUTH

 11-10-13 13:11 1 WET RED MATERIAL AROUND MOUTH

 11-11-13 12:47 1 WET CLEAR MATERIAL AROUND MOUTH

 11-17-13 11:49 2 WET CLEAR MATERIAL AROUND MOUTH

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

 PCRDv4.18

 01/24/2014

Page 448 of 1107
 TABLE A7 (F0 FEMALES - 1 HOUR POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91624 F 10000 PPM NORMAL 10-14-13 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 13:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 13:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 12:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 12:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 13:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 13:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 12:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 12:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 12:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 13:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 13:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 13:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 12:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 12:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 12:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 12:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 12:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 12:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 13:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 12:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 13:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 13:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 449 of 1107
 TABLE A7 (F0 FEMALES - 1 HOUR POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91624 F 10000 PPM NORMAL 11-12-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 12:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 13:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 12:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 12:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 13:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-19-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91625 F 10000 PPM NORMAL 10-15-13 13:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 12:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 12:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 12:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 13:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 12:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 12:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 13:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 12:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 12:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 13:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91625 F 10000 PPM BODY/INTEGUMENT 10-28-13 13:41 3 WET CLEAR MATERIAL VENTRAL NECK

 10-29-13 13:07 3 WET CLEAR MATERIAL VENTRAL NECK

 10-29-13 13:08 2 WET CLEAR MATERIAL LEFT FORELIMB

 10-29-13 13:08 2 WET CLEAR MATERIAL RIGHT FORELIMB

 11-01-13 12:15 3 WET CLEAR MATERIAL VENTRAL NECK

 11-01-13 12:15 2 WET CLEAR MATERIAL LEFT FORELIMB

 11-01-13 12:15 2 WET CLEAR MATERIAL RIGHT FORELIMB

 11-03-13 12:03 2 WET CLEAR MATERIAL VENTRAL NECK

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 450 of 1107
 TABLE A7 (F0 FEMALES - 1 HOUR POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91625 F 10000 PPM BODY/INTEGUMENT 11-03-13 12:03 1 WET CLEAR MATERIAL LEFT FORELIMB

 11-04-13 12:42 3 WET CLEAR MATERIAL VENTRAL NECK

 11-04-13 12:42 2 WET CLEAR MATERIAL LEFT FORELIMB

 11-04-13 12:42 2 WET CLEAR MATERIAL RIGHT FORELIMB

 11-05-13 12:00 2 WET CLEAR MATERIAL VENTRAL NECK

 11-05-13 12:00 2 WET CLEAR MATERIAL RIGHT FORELIMB

 11-05-13 12:00 2 WET CLEAR MATERIAL LEFT FORELIMB

 11-06-13 12:22 3 WET CLEAR MATERIAL VENTRAL NECK

 11-06-13 12:22 2 WET CLEAR MATERIAL LEFT FORELIMB

 11-06-13 12:22 2 WET CLEAR MATERIAL RIGHT FORELIMB

 11-07-13 12:37 3 WET CLEAR MATERIAL VENTRAL NECK

 11-07-13 12:37 3 WET CLEAR MATERIAL LEFT FORELIMB

 11-07-13 12:37 3 WET CLEAR MATERIAL RIGHT FORELIMB

 11-09-13 12:39 2 WET CLEAR MATERIAL RIGHT FORELIMB

 11-09-13 12:40 2 WET CLEAR MATERIAL VENTRAL NECK

 11-09-13 12:40 2 WET CLEAR MATERIAL LEFT FORELIMB

 11-10-13 13:53 2 WET CLEAR MATERIAL VENTRAL NECK

 11-10-13 13:53 1 WET CLEAR MATERIAL LEFT FORELIMB

 11-10-13 13:54 1 WET CLEAR MATERIAL RIGHT FORELIMB

 11-11-13 13:20 3 WET CLEAR MATERIAL VENTRAL NECK

 11-11-13 13:20 3 WET CLEAR MATERIAL LEFT FORELIMB

 11-11-13 13:20 3 WET CLEAR MATERIAL RIGHT FORELIMB

 11-12-13 12:13 2 WET CLEAR MATERIAL VENTRAL NECK

 11-12-13 12:13 2 WET CLEAR MATERIAL LEFT FORELIMB

 11-12-13 12:13 2 WET CLEAR MATERIAL RIGHT FORELIMB

 11-13-13 12:20 2 WET CLEAR MATERIAL VENTRAL NECK

 11-13-13 12:20 2 WET CLEAR MATERIAL LEFT FORELIMB

 11-13-13 12:20 2 WET CLEAR MATERIAL RIGHT FORELIMB

 11-14-13 13:37 3 WET CLEAR MATERIAL VENTRAL NECK

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 451 of 1107
 TABLE A7 (F0 FEMALES - 1 HOUR POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91625 F 10000 PPM BODY/INTEGUMENT 11-14-13 13:37 3 WET CLEAR MATERIAL LEFT FORELIMB

 11-14-13 13:37 3 WET CLEAR MATERIAL RIGHT FORELIMB

 11-15-13 12:32 2 WET CLEAR MATERIAL VENTRAL NECK

 11-15-13 12:32 2 WET CLEAR MATERIAL LEFT FORELIMB

 11-15-13 12:32 2 WET CLEAR MATERIAL RIGHT FORELIMB

 11-17-13 12:35 1 WET CLEAR MATERIAL RIGHT FORELIMB

 11-17-13 12:35 1 WET CLEAR MATERIAL LEFT FORELIMB

 11-17-13 12:35 1 WET CLEAR MATERIAL VENTRAL NECK

 11-18-13 13:14 3 WET CLEAR MATERIAL VENTRAL NECK

 11-18-13 13:14 3 WET CLEAR MATERIAL LEFT FORELIMB

 11-18-13 13:14 3 WET CLEAR MATERIAL RIGHT FORELIMB

 11-19-13 12:34 3 WET CLEAR MATERIAL VENTRAL NECK

 11-19-13 12:34 3 WET CLEAR MATERIAL LEFT FORELIMB

 11-19-13 12:34 3 WET CLEAR MATERIAL RIGHT FORELIMB

 11-19-13 12:35 3 WET CLEAR MATERIAL VENTRAL ABDOMINAL AREA

 91625 F 10000 PPM EYES/EARS/NOSE 10-24-13 14:19 1 WET RED MATERIAL AROUND NOSE

 11-07-13 12:37 2 DRIED RED MATERIAL AROUND NOSE

 11-09-13 12:39 2 WET RED MATERIAL AROUND NOSE

 91625 F 10000 PPM ORAL/DENTAL 10-14-13 14:17 1 WET CLEAR MATERIAL AROUND MOUTH

 10-19-13 12:01 1 WET RED MATERIAL AROUND MOUTH

 10-20-13 11:56 2 WET RED MATERIAL AROUND MOUTH

 10-21-13 13:13 1 DRIED RED MATERIAL AROUND MOUTH

 10-23-13 12:21 2 WET CLEAR MATERIAL AROUND MOUTH

 10-24-13 14:18 2 WET CLEAR MATERIAL AROUND MOUTH

 10-28-13 13:41 3 WET CLEAR MATERIAL AROUND MOUTH

 10-29-13 13:08 3 WET CLEAR MATERIAL AROUND MOUTH

 11-01-13 12:15 2 WET CLEAR MATERIAL AROUND MOUTH

 11-04-13 12:42 1 WET CLEAR MATERIAL AROUND MOUTH

 11-06-13 12:22 3 WET CLEAR MATERIAL AROUND MOUTH

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 452 of 1107
 TABLE A7 (F0 FEMALES - 1 HOUR POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91625 F 10000 PPM ORAL/DENTAL 11-07-13 12:37 3 WET CLEAR MATERIAL AROUND MOUTH

 11-09-13 12:39 2 WET CLEAR MATERIAL AROUND MOUTH

 11-11-13 13:20 3 WET CLEAR MATERIAL AROUND MOUTH

 11-12-13 12:13 2 WET CLEAR MATERIAL AROUND MOUTH

 11-14-13 13:37 2 WET CLEAR MATERIAL AROUND MOUTH

 11-15-13 12:32 1 WET CLEAR MATERIAL AROUND MOUTH

 11-18-13 13:14 2 WET CLEAR MATERIAL AROUND MOUTH

 11-19-13 12:35 3 WET CLEAR MATERIAL AROUND MOUTH

 91627 F 10000 PPM NORMAL 10-14-13 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 13:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 13:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 12:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 12:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 13:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 13:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 12:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 13:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 13:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 13:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 12:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 12:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 12:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 12:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 453 of 1107
 TABLE A7 (F0 FEMALES - 1 HOUR POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91627 F 10000 PPM NORMAL 11-05-13 12:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 12:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 13:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 12:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 13:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 13:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 12:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 13:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 12:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 12:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 12:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91627 F 10000 PPM ORAL/DENTAL 10-23-13 12:25 1 DRIED RED MATERIAL AROUND MOUTH

 91634 F 10000 PPM NORMAL 10-14-13 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 13:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 13:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 12:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 13:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 13:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 12:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 12:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 13:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 454 of 1107
 TABLE A7 (F0 FEMALES - 1 HOUR POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91634 F 10000 PPM NORMAL 10-30-13 13:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 12:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 12:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 12:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 12:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 12:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 12:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 13:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 12:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 13:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 12:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 13:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 12:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 13:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-19-13 12:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-20-13 13:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91634 F 10000 PPM EYES/EARS/NOSE 10-28-13 13:42 1 DRIED RED MATERIAL AROUND NOSE

 91634 F 10000 PPM ORAL/DENTAL 11-10-13 13:55 1 DRIED RED MATERIAL AROUND MOUTH

 91635 F 10000 PPM NORMAL 10-14-13 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 13:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 12:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 12:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 12:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 12:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 455 of 1107
 TABLE A7 (F0 FEMALES - 1 HOUR POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91635 F 10000 PPM NORMAL 10-20-13 11:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 13:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 13:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 12:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 12:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 12:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 13:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 13:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 13:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 12:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 12:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 12:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 12:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 12:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 12:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 12:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 12:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 13:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 12:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 13:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 13:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 12:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 12:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 13:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 12:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 456 of 1107
 TABLE A7 (F0 FEMALES - 1 HOUR POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91638 F 10000 PPM NORMAL 10-14-13 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 13:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 12:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 12:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 12:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 12:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 11:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 13:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 13:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 12:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 12:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 12:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 13:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 13:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 12:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 12:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 12:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 12:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 12:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 12:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 12:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 12:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 13:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 12:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 13:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 13:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 12:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 457 of 1107
 TABLE A7 (F0 FEMALES - 1 HOUR POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91638 F 10000 PPM NORMAL 11-13-13 12:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 13:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 12:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 12:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 13:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-19-13 12:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91638 F 10000 PPM EYES/EARS/NOSE 10-28-13 13:42 2 DRIED RED MATERIAL AROUND NOSE

 91652 F 10000 PPM NORMAL 10-14-13 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 13:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 13:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 12:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 13:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 13:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 12:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 12:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 13:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 12:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 12:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 12:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 12:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 12:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 458 of 1107
 TABLE A7 (F0 FEMALES - 1 HOUR POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 11

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91652 F 10000 PPM NORMAL 11-06-13 12:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 13:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 12:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 13:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 13:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 12:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 13:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 12:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 12:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 12:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91652 F 10000 PPM EYES/EARS/NOSE 10-28-13 13:42 3 DRIED RED MATERIAL AROUND NOSE

 10-29-13 13:09 2 DRIED RED MATERIAL AROUND NOSE

 91655 F 10000 PPM NORMAL 10-14-13 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 13:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 12:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 12:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 12:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 12:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 11:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 13:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 13:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 12:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 12:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 12:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 13:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 459 of 1107
 TABLE A7 (F0 FEMALES - 1 HOUR POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 12

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91655 F 10000 PPM NORMAL 10-30-13 13:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 12:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 12:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 12:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 13:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 13:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 13:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 12:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 13:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 12:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91655 F 10000 PPM EYES/EARS/NOSE 10-28-13 13:40 3 DRIED RED MATERIAL AROUND NOSE

 91655 F 10000 PPM ORAL/DENTAL 11-16-13 12:39 1 DRIED RED MATERIAL AROUND MOUTH

 91658 F 10000 PPM NORMAL 10-15-13 13:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 13:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 12:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 12:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 13:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 13:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 12:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 460 of 1107
 TABLE A7 (F0 FEMALES - 1 HOUR POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 13

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91658 F 10000 PPM NORMAL 10-25-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 12:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 12:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 13:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 12:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 12:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 12:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 12:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 12:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 12:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 13:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 12:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 13:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 12:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 13:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 12:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 12:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 13:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91658 F 10000 PPM EYES/EARS/NOSE 10-24-13 14:17 1 DRIED RED MATERIAL AROUND NOSE

 10-29-13 13:10 2 DRIED RED MATERIAL AROUND NOSE

 10-30-13 13:20 1 DRIED RED MATERIAL AROUND NOSE

 10-31-13 12:37 1 DRIED RED MATERIAL AROUND NOSE

 11-11-13 13:22 3 DRIED RED MATERIAL AROUND NOSE

 11-17-13 12:37 1 DRIED RED MATERIAL AROUND NOSE

 91658 F 10000 PPM ORAL/DENTAL 10-14-13 14:19 1 WET CLEAR MATERIAL AROUND MOUTH

 10-29-13 13:10 2 DRIED RED MATERIAL AROUND MOUTH

 10-30-13 13:20 1 DRIED RED MATERIAL AROUND MOUTH

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 461 of 1107
 TABLE A7 (F0 FEMALES - 1 HOUR POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 14

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91667 F 10000 PPM NORMAL 10-14-13 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 13:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 12:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 12:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 12:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 12:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 11:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 13:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 13:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 12:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 12:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 12:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 13:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 13:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 13:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 12:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 12:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 12:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 13:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 13:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 13:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 462 of 1107
 TABLE A7 (F0 FEMALES - 1 HOUR POST-EXPOSURE - GROUP 5)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91667 F 10000 PPM NORMAL 11-12-13 12:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 13:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 12:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 13:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91668 F 10000 PPM NORMAL 10-14-13 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 13:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 12:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 12:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 12:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 12:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 11:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 13:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 13:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 12:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 12:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 12:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 13:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 13:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 13:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 12:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 12:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 463 of 1107
 TABLE A7 (F0 FEMALES - 1 HOUR POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 16

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91668 F 10000 PPM NORMAL 11-05-13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 12:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 12:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 13:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 13:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 13:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 12:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 13:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 12:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 12:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 13:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91680 F 10000 PPM NORMAL 10-14-13 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 13:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 13:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 12:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 12:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 13:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 13:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 12:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 12:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 12:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 13:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 464 of 1107
 TABLE A7 (F0 FEMALES - 1 HOUR POST-EXPOSURE - GROUP 5)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 17

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 11-20-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91680 F 10000 PPM NORMAL 10-30-13 13:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 12:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 12:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 12:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 12:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 12:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 12:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 12:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 13:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 12:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 13:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 13:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 12:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 13:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 12:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 12:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 12:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91680 F 10000 PPM EYES/EARS/NOSE 10-28-13 13:43 1 DRIED RED MATERIAL AROUND NOSE

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

 PCRDv4.18

 01/20/2014

Page 465 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91629 F 0 PPM NORMAL 10-14-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 466 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91629 F 0 PPM NORMAL 11-12-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-19-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-20-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91630 F 0 PPM NORMAL 10-14-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 467 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91630 F 0 PPM NORMAL 11-04-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-19-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-20-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91630 F 0 PPM EYES/EARS/NOSE 10-28-13 16:55 1 DRIED RED MATERIAL AROUND NOSE

 91633 F 0 PPM NORMAL 10-14-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 468 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91633 F 0 PPM NORMAL 10-25-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91637 F 0 PPM NORMAL 10-14-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 469 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91637 F 0 PPM NORMAL 10-18-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 470 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91637 F 0 PPM NORMAL 11-16-13 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91639 F 0 PPM NORMAL 10-14-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

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 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91639 F 0 PPM NORMAL 11-11-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-19-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91639 F 0 PPM EYES/EARS/NOSE 10-28-13 16:55 1 DRIED RED MATERIAL AROUND NOSE

 91644 F 0 PPM NORMAL 10-14-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 472 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91644 F 0 PPM NORMAL 11-02-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91645 F 0 PPM NORMAL 10-14-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 473 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91645 F 0 PPM NORMAL 10-26-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-19-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-20-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91648 F 0 PPM NORMAL 10-14-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 474 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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 TABLE RANGE: 10-14-13 TO 12-04-13

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 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91648 F 0 PPM NORMAL 10-17-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 475 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91648 F 0 PPM NORMAL 11-15-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91653 F 0 PPM NORMAL 10-14-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 476 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

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-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91653 F 0 PPM NORMAL 11-09-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-19-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91660 F 0 PPM NORMAL 10-14-13 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 477 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91660 F 0 PPM NORMAL 11-01-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-19-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91670 F 0 PPM NORMAL 10-14-13 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 478 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91670 F 0 PPM NORMAL 10-25-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-19-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-20-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91670 F 0 PPM EYES/EARS/NOSE 10-18-13 15:09 1 DRIED RED MATERIAL AROUND NOSE

 91672 F 0 PPM NORMAL 10-14-13 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 479 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

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-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91672 F 0 PPM NORMAL 10-15-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 480 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91672 F 0 PPM NORMAL 11-13-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-19-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-20-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91632 F 50 PPM NORMAL 10-14-13 17:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 481 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

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-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91632 F 50 PPM NORMAL 11-05-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-19-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-20-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-21-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91632 F 50 PPM EYES/EARS/NOSE 11-02-13 14:46 1 DRIED RED MATERIAL AROUND NOSE

 91640 F 50 PPM NORMAL 10-14-13 17:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 482 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91640 F 50 PPM NORMAL 10-29-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91640 F 50 PPM EYES/EARS/NOSE 10-16-13 15:18 1 DRIED RED MATERIAL AROUND NOSE

 10-18-13 15:10 1 DRIED RED MATERIAL AROUND NOSE

 10-23-13 15:09 1 DRIED RED MATERIAL AROUND NOSE

 10-28-13 16:57 1 DRIED RED MATERIAL AROUND NOSE

 11-02-13 14:46 1 DRIED RED MATERIAL AROUND NOSE

 11-11-13 16:00 1 DRIED RED MATERIAL AROUND NOSE

 11-12-13 15:06 1 DRIED RED MATERIAL AROUND NOSE

 11-13-13 15:08 1 DRIED RED MATERIAL AROUND NOSE

 11-15-13 15:28 1 DRIED RED MATERIAL AROUND NOSE

 11-16-13 14:33 1 DRIED RED MATERIAL AROUND NOSE

 11-17-13 15:16 1 DRIED RED MATERIAL AROUND NOSE

 11-18-13 15:40 2 DRIED RED MATERIAL AROUND NOSE

 11-19-13 15:16 1 DRIED RED MATERIAL AROUND NOSE

 11-20-13 15:31 1 DRIED RED MATERIAL AROUND NOSE

 11-21-13 15:10 1 DRIED RED MATERIAL AROUND NOSE

 91642 F 50 PPM NORMAL 10-14-13 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 483 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91642 F 50 PPM NORMAL 10-15-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 484 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91642 F 50 PPM NORMAL 11-14-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91642 F 50 PPM EYES/EARS/NOSE 10-28-13 16:57 2 DRIED RED MATERIAL AROUND NOSE

 11-18-13 15:41 1 DRIED RED MATERIAL AROUND NOSE

 91647 F 50 PPM NORMAL 10-14-13 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 485 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91647 F 50 PPM NORMAL 11-06-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-19-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-20-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91651 F 50 PPM NORMAL 10-14-13 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 486 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91651 F 50 PPM NORMAL 10-28-13 16:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91659 F 50 PPM NORMAL 10-14-13 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 487 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91659 F 50 PPM NORMAL 10-22-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91659 F 50 PPM EYES/EARS/NOSE 10-18-13 15:11 1 DRIED RED MATERIAL AROUND NOSE

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 488 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91661 F 50 PPM NORMAL 10-14-13 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 489 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91661 F 50 PPM NORMAL 11-13-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91661 F 50 PPM EYES/EARS/NOSE 10-28-13 16:59 2 DRIED RED MATERIAL AROUND NOSE

 91663 F 50 PPM NORMAL 10-14-13 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

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 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91663 F 50 PPM NORMAL 11-07-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-19-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91663 F 50 PPM EYES/EARS/NOSE 10-28-13 16:59 1 DRIED RED MATERIAL AROUND NOSE

 11-17-13 15:16 1 DRIED RED MATERIAL AROUND NOSE

 91669 F 50 PPM NORMAL 10-14-13 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 491 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91669 F 50 PPM NORMAL 10-29-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91673 F 50 PPM NORMAL 10-14-13 17:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 492 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91673 F 50 PPM NORMAL 10-25-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-19-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-20-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91673 F 50 PPM EYES/EARS/NOSE 10-15-13 15:42 1 DRIED RED MATERIAL AROUND NOSE

 10-23-13 15:10 1 DRIED RED MATERIAL AROUND NOSE

 10-28-13 16:59 2 DRIED RED MATERIAL AROUND NOSE

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 493 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91683 F 50 PPM NORMAL 10-14-13 17:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 494 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91683 F 50 PPM NORMAL 11-14-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-19-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-20-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-21-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91683 F 50 PPM EYES/EARS/NOSE 10-28-13 17:00 1 DRIED RED MATERIAL AROUND NOSE

 11-02-13 14:47 1 DRIED RED MATERIAL AROUND NOSE

 91685 F 50 PPM NORMAL 10-14-13 17:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 495 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91685 F 50 PPM NORMAL 11-02-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91685 F 50 PPM EYES/EARS/NOSE 11-16-13 14:35 1 DRIED RED MATERIAL AROUND NOSE

 91620 F 100 PPM NORMAL 10-15-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 496 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91620 F 100 PPM NORMAL 10-28-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-19-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91620 F 100 PPM EYES/EARS/NOSE 10-14-13 17:11 1 DRIED RED MATERIAL AROUND NOSE

 91628 F 100 PPM NORMAL 10-14-13 17:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 497 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91628 F 100 PPM NORMAL 10-19-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 498 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

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-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91628 F 100 PPM NORMAL 11-18-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91628 F 100 PPM EYES/EARS/NOSE 10-28-13 17:01 1 DRIED RED MATERIAL AROUND NOSE

 91631 F 100 PPM NORMAL 10-14-13 17:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 499 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91631 F 100 PPM NORMAL 11-14-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91631 F 100 PPM EYES/EARS/NOSE 10-19-13 15:07 1 DRIED RED MATERIAL AROUND NOSE

 10-21-13 15:57 1 DRIED RED MATERIAL AROUND NOSE

 10-22-13 15:21 1 DRIED RED MATERIAL AROUND NOSE

 10-23-13 15:15 1 DRIED RED MATERIAL AROUND NOSE

 91636 F 100 PPM NORMAL 10-14-13 17:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 500 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91636 F 100 PPM NORMAL 11-05-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-19-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91636 F 100 PPM EYES/EARS/NOSE 10-23-13 15:15 2 DRIED RED MATERIAL AROUND NOSE

 11-02-13 14:48 1 DRIED RED MATERIAL AROUND NOSE

 91649 F 100 PPM NORMAL 10-14-13 17:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 501 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91649 F 100 PPM NORMAL 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91649 F 100 PPM EYES/EARS/NOSE 11-02-13 14:48 1 DRIED RED MATERIAL AROUND NOSE

 91650 F 100 PPM NORMAL 10-14-13 17:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 502 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91650 F 100 PPM NORMAL 10-21-13 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91650 F 100 PPM EYES/EARS/NOSE 10-20-13 14:54 1 DRIED RED MATERIAL AROUND NOSE

 11-16-13 14:36 1 DRIED RED MATERIAL AROUND NOSE

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 503 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91656 F 100 PPM NORMAL 10-14-13 17:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 504 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91656 F 100 PPM NORMAL 11-13-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-19-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-20-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-21-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-22-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91656 F 100 PPM EYES/EARS/NOSE 10-23-13 15:16 1 DRIED RED MATERIAL AROUND NOSE

 11-16-13 14:36 1 DRIED RED MATERIAL AROUND NOSE

 91671 F 100 PPM NORMAL 10-14-13 17:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 505 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91671 F 100 PPM NORMAL 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-19-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-20-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-21-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91675 F 100 PPM NORMAL 10-14-13 17:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 506 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91675 F 100 PPM NORMAL 10-24-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91675 F 100 PPM EYES/EARS/NOSE 10-19-13 15:08 1 DRIED RED MATERIAL AROUND NOSE

 10-23-13 15:16 1 DRIED RED MATERIAL AROUND NOSE

 10-28-13 17:02 2 DRIED RED MATERIAL AROUND NOSE

 10-29-13 15:47 1 DRIED RED MATERIAL AROUND NOSE

 11-02-13 14:48 1 DRIED RED MATERIAL AROUND NOSE

 11-11-13 16:03 1 DRIED RED MATERIAL AROUND NOSE

 91677 F 100 PPM NORMAL 10-14-13 17:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 507 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91677 F 100 PPM NORMAL 10-16-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 508 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

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-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91677 F 100 PPM NORMAL 11-16-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91677 F 100 PPM EYES/EARS/NOSE 10-22-13 15:23 1 DRIED RED MATERIAL AROUND NOSE

 10-23-13 15:16 1 DRIED RED MATERIAL AROUND NOSE

 91679 F 100 PPM NORMAL 10-14-13 17:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

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 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91679 F 100 PPM NORMAL 11-07-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91679 F 100 PPM EYES/EARS/NOSE 11-12-13 15:09 1 DRIED RED MATERIAL AROUND NOSE

 91684 F 100 PPM NORMAL 10-14-13 17:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 510 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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 TABLE RANGE: 10-14-13 TO 12-04-13

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 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91684 F 100 PPM NORMAL 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91684 F 100 PPM EYES/EARS/NOSE 11-16-13 14:37 1 DRIED RED MATERIAL AROUND NOSE

 91622 F 175 PPM NORMAL 10-14-13 17:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 511 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91622 F 175 PPM NORMAL 10-29-13 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91622 F 175 PPM EYES/EARS/NOSE 10-20-13 14:55 1 DRIED RED MATERIAL AROUND NOSE

 10-21-13 15:59 1 DRIED RED MATERIAL AROUND NOSE

 10-23-13 15:17 2 DRIED RED MATERIAL AROUND NOSE

 10-28-13 17:04 2 DRIED RED MATERIAL AROUND NOSE

 11-03-13 14:50 1 DRIED RED MATERIAL AROUND NOSE

 11-12-13 15:09 1 DRIED RED MATERIAL AROUND NOSE

 11-16-13 14:37 1 DRIED RED MATERIAL AROUND NOSE

 91623 F 175 PPM NORMAL 10-14-13 17:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

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GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 512 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91623 F 175 PPM NORMAL 10-19-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-19-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

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 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91623 F 175 PPM NORMAL 11-20-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-21-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-22-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-23-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-24-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-25-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-27-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-29-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-30-13 14:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 12-01-13 14:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 12-02-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 12-03-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 12-04-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91623 F 175 PPM EYES/EARS/NOSE 10-23-13 15:17 1 DRIED RED MATERIAL AROUND NOSE

 11-11-13 16:04 1 DRIED RED MATERIAL AROUND NOSE

 11-12-13 15:10 1 DRIED RED MATERIAL AROUND NOSE

 11-26-13 15:02 1 DRIED RED MATERIAL AROUND NOSE

 11-28-13 14:32 1 DRIED RED MATERIAL AROUND NOSE

 91626 F 175 PPM NORMAL 10-14-13 17:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 514 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91626 F 175 PPM NORMAL 10-25-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-20-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91626 F 175 PPM EYES/EARS/NOSE 10-28-13 17:04 1 DRIED RED MATERIAL AROUND NOSE

 10-29-13 15:48 1 DRIED RED MATERIAL AROUND NOSE

 11-08-13 15:02 1 DRIED RED MATERIAL AROUND NOSE

 11-10-13 17:04 1 DRIED RED MATERIAL AROUND NOSE

 11-11-13 16:04 1 DRIED RED MATERIAL AROUND NOSE

 11-13-13 15:13 1 DRIED RED MATERIAL AROUND NOSE

 11-19-13 15:18 1 DRIED RED MATERIAL AROUND NOSE

 91643 F 175 PPM NORMAL 10-14-13 17:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 515 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91643 F 175 PPM NORMAL 10-16-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 516 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91643 F 175 PPM NORMAL 11-15-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-19-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-20-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-21-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-22-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-23-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91643 F 175 PPM EYES/EARS/NOSE 10-22-13 15:24 1 DRIED RED MATERIAL AROUND NOSE

 91654 F 175 PPM NORMAL 10-14-13 17:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 517 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91654 F 175 PPM NORMAL 11-05-13 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-19-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-21-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-22-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91654 F 175 PPM EYES/EARS/NOSE 10-24-13 15:04 1 DRIED RED MATERIAL AROUND NOSE

 10-29-13 15:49 2 WET RED MATERIAL AROUND NOSE

 10-29-13 15:49 1 DRIED RED MATERIAL AROUND NOSE

 11-03-13 14:52 2 DRIED RED MATERIAL AROUND NOSE

 11-11-13 16:05 1 DRIED RED MATERIAL AROUND NOSE

 11-15-13 15:32 1 DRIED RED MATERIAL AROUND NOSE

 11-16-13 14:38 1 DRIED RED MATERIAL AROUND NOSE

 11-20-13 15:33 1 DRIED RED MATERIAL AROUND NOSE

 91657 F 175 PPM NORMAL 10-14-13 17:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

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 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91657 F 175 PPM NORMAL 10-21-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-19-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 519 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91657 F 175 PPM NORMAL 11-20-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-21-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-22-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-23-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-24-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-25-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-26-13 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-27-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-28-13 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91657 F 175 PPM EYES/EARS/NOSE 11-02-13 14:50 1 DRIED RED MATERIAL AROUND NOSE

 91662 F 175 PPM NORMAL 10-14-13 17:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 520 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91662 F 175 PPM NORMAL 11-02-13 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-19-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91662 F 175 PPM EYES/EARS/NOSE 11-11-13 16:05 1 DRIED RED MATERIAL AROUND NOSE

 11-12-13 15:10 1 DRIED RED MATERIAL AROUND NOSE

 11-15-13 15:32 1 DRIED RED MATERIAL AROUND NOSE

 91666 F 175 PPM NORMAL 10-14-13 17:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 521 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91666 F 175 PPM NORMAL 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91666 F 175 PPM EYES/EARS/NOSE 11-02-13 14:51 1 DRIED RED MATERIAL AROUND NOSE

 91676 F 175 PPM NORMAL 10-14-13 17:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 522 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91676 F 175 PPM NORMAL 10-19-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 523 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

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-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91676 F 175 PPM NORMAL 11-18-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91676 F 175 PPM EYES/EARS/NOSE 10-28-13 17:06 1 DRIED RED MATERIAL AROUND NOSE

 91678 F 175 PPM NORMAL 10-14-13 17:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 524 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91678 F 175 PPM NORMAL 11-10-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91678 F 175 PPM EYES/EARS/NOSE 11-16-13 14:39 1 DRIED RED MATERIAL AROUND NOSE

 91681 F 175 PPM NORMAL 10-14-13 17:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 525 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91681 F 175 PPM NORMAL 11-06-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-22-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-23-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-24-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-25-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91681 F 175 PPM EYES/EARS/NOSE 11-02-13 14:51 2 DRIED RED MATERIAL AROUND NOSE

 11-03-13 14:53 1 DRIED RED MATERIAL AROUND NOSE

 11-08-13 15:03 1 DRIED RED MATERIAL AROUND NOSE

 11-13-13 15:14 1 DRIED RED MATERIAL AROUND NOSE

 11-15-13 15:32 1 DRIED RED MATERIAL AROUND NOSE

 11-18-13 15:45 1 DRIED RED MATERIAL AROUND NOSE

 11-19-13 15:18 2 DRIED RED MATERIAL AROUND NOSE

 11-20-13 15:33 1 DRIED RED MATERIAL AROUND NOSE

 11-21-13 15:11 1 DRIED RED MATERIAL AROUND NOSE

 11-26-13 15:02 1 DRIED RED MATERIAL AROUND NOSE

 91682 F 175 PPM NORMAL 10-14-13 17:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 526 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91682 F 175 PPM NORMAL 10-20-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-19-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91682 F 175 PPM EYES/EARS/NOSE 10-22-13 15:26 1 DRIED RED MATERIAL AROUND NOSE

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

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 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91682 F 175 PPM EYES/EARS/NOSE 10-28-13 17:07 1 DRIED RED MATERIAL AROUND NOSE

 11-02-13 14:51 1 DRIED RED MATERIAL AROUND NOSE

 91624 F 10000 PPM NORMAL 10-14-13 17:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 528 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91624 F 10000 PPM NORMAL 11-10-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-19-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91625 F 10000 PPM NORMAL 10-14-13 17:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 529 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91625 F 10000 PPM NORMAL 11-03-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-19-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91625 F 10000 PPM ORAL/DENTAL 10-29-13 15:51 1 DRIED RED MATERIAL AROUND MOUTH

 91627 F 10000 PPM NORMAL 10-14-13 17:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 530 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91627 F 10000 PPM NORMAL 10-26-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91627 F 10000 PPM EYES/EARS/NOSE 10-21-13 16:01 1 DRIED RED MATERIAL AROUND NOSE

 91634 F 10000 PPM NORMAL 10-14-13 17:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 531 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91634 F 10000 PPM NORMAL 10-19-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 532 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91634 F 10000 PPM NORMAL 11-18-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-19-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-20-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91634 F 10000 PPM EYES/EARS/NOSE 11-16-13 14:41 1 DRIED RED MATERIAL AROUND NOSE

 91635 F 10000 PPM NORMAL 10-14-13 17:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 533 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91635 F 10000 PPM NORMAL 11-08-13 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91638 F 10000 PPM NORMAL 10-14-13 17:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 534 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91638 F 10000 PPM NORMAL 11-04-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-19-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91638 F 10000 PPM EYES/EARS/NOSE 10-23-13 15:23 1 DRIED RED MATERIAL AROUND NOSE

 10-29-13 15:52 1 DRIED RED MATERIAL AROUND NOSE

 91652 F 10000 PPM NORMAL 10-14-13 17:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 535 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91652 F 10000 PPM NORMAL 10-25-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91652 F 10000 PPM EYES/EARS/NOSE 10-29-13 15:52 1 DRIED RED MATERIAL AROUND NOSE

 91655 F 10000 PPM NORMAL 10-14-13 17:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 536 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

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SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91655 F 10000 PPM NORMAL 10-19-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 537 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 73

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91655 F 10000 PPM NORMAL 11-17-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91658 F 10000 PPM NORMAL 10-15-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 538 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 74

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91658 F 10000 PPM NORMAL 11-14-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91658 F 10000 PPM EYES/EARS/NOSE 10-14-13 17:17 1 DRIED RED MATERIAL AROUND NOSE

 10-29-13 15:53 1 DRIED RED MATERIAL AROUND NOSE

 11-01-13 15:09 1 DRIED RED MATERIAL AROUND NOSE

 11-17-13 15:22 1 DRIED RED MATERIAL AROUND NOSE

 91658 F 10000 PPM ORAL/DENTAL 10-29-13 15:53 1 DRIED RED MATERIAL AROUND MOUTH

 91667 F 10000 PPM NORMAL 10-14-13 17:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 539 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 75

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91667 F 10000 PPM NORMAL 11-03-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91667 F 10000 PPM EYES/EARS/NOSE 11-17-13 15:22 1 DRIED RED MATERIAL AROUND NOSE

 91668 F 10000 PPM NORMAL 10-14-13 17:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-20-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 540 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 76

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91668 F 10000 PPM NORMAL 10-27-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-18-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91680 F 10000 PPM NORMAL 10-14-13 17:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-15-13 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-16-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-17-13 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-18-13 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-19-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

Page 541 of 1107
 TABLE A8 (F0 FEMALES - 1 HOUR FOLLOWING 6-HOUR EXPOSURE PERIOD)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 77

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CLINICAL OBSERVATIONS

 TABLE RANGE: 10-14-13 TO 12-04-13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91680 F 10000 PPM NORMAL 10-20-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-21-13 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-22-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-23-13 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-24-13 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-25-13 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-26-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-27-13 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-28-13 16:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-29-13 15:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-30-13 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 10-31-13 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-01-13 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-02-13 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-03-13 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-04-13 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-05-13 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-06-13 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-07-13 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-08-13 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-09-13 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-10-13 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-11-13 16:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-12-13 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-13-13 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-14-13 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-15-13 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-16-13 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 11-17-13 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

 PCRDv4.18

 01/20/2014

 R:01/21/2014

Page 542 of 1107
 TABLE A9 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 0 7 13 21 28

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 1: 0 PPM

-------------------------------------------

 91555 384. 399. 422. 434. 460.

 91560 364. 386. 407. 432. 458.

 91562 371. 384. 392. 408. 430.

 91563 353. 370. 388. 396. 414.

 91564 368. 376. 397. 403. 416.

 91567 347. 362. 371. 383. 411.

 91579 386. 395. 419. 447. 469.

 91586 364. 373. 401. 437. 458.

 91591 384. 398. 412. 430. 456.

 91592 403. 425. 455. 477. 499.

 91609 359. 375. 400. 418. 440.

 91615 366. 397. 419. 429. 469.

 MEAN 371. 387. 407. 424. 448.

 S.D. 16.0 17.3 21.2 25.1 26.8

 S.E. 4.6 5.0 6.1 7.3 7.7

 N 12 12 12 12 12

Page 543 of 1107
 TABLE A9 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 0 7 13 21 28

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 2: 50 PPM

-------------------------------------------

 91556 367. 396. 415. 436. 452.

 91559 375. 379. 393. 410. 428.

 91561 345. 379. 413. 437. 455.

 91566 359. 377. 395. 410. 428.

 91576 355. 367. 390. 398. 413.

 91582 413. 427. 454. 477. 513.

 91585 382. 416. 437. 460. 484.

 91589 345. 356. 383. 398. 416.

 91593 376. 395. 421. 436. 456.

 91594 373. 391. 418. 435. 452.

 91595 390. 416. 440. 462. 485.

 91602 388. 415. 442. 475. 495.

 MEAN 372. 393. 417. 436. 456.

 S.D. 19.9 22.2 23.2 28.2 32.1

 S.E. 5.8 6.4 6.7 8.1 9.3

 N 12 12 12 12 12

Page 544 of 1107
 TABLE A9 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 0 7 13 21 28

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 3: 100 PPM

-------------------------------------------

 91569 368. 369. 389. 409. 430.

 91573 363. 378. 380. 391. 414.

 91577 354. 367. 387. 397. 413.

 91581 410. 395. 392. 425. 439.

 91583 377. 383. 391. 406. 407.

 91588 391. 403. 420. 433. 456.

 91590 387. 397. 421. 434. 448.

 91598 355. 380. 391. 400. 410.

 91599 350. 368. 390. 399. 416.

 91608 367. 388. 411. 427. 447.

 91611 386. 408. 422. 433. 441.

 91616 379. 391. 419. 424. 452.

 MEAN 374. 386. 401. 415. 431.

 S.D. 17.7 13.7 16.0 16.0 18.1

 S.E. 5.1 4.0 4.6 4.6 5.2

 N 12 12 12 12 12

Page 545 of 1107
 TABLE A9 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 0 7 13 21 28

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 4: 175 PPM

-------------------------------------------

 91565 345. 351. 372. 395. 405.

 91568 400. 427. 437. 441. 439.

 91570 370. 387. 415. 419. 425.

 91572 377. 374. 393. 410. 427.

 91580 348. 367. 389. 404. 412.

 91584 367. 377. 404. 417. 427.

 91587 358. 396. 426. 450. 472.

 91597 367. 384. 397. 419. 437.

 91601 353. 368. 391. 410. 430.

 91607 385. 384. 405. 437. 468.

 91613 385. 380. 409. 439. 451.

 91614 381. 408. 436. 436. 466.

 MEAN 370. 384. 406. 423. 438.

 S.D. 16.5 20.0 19.8 17.1 21.9

 S.E. 4.8 5.8 5.7 4.9 6.3

 N 12 12 12 12 12

Page 546 of 1107
 TABLE A9 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 0 7 13 21 28

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 5: 10000 PPM

-------------------------------------------

 91554 355. 369. 380. 398. 413.

 91557 385. 397. 411. 440. 459.

 91558 386. 382. 405. 409. 423.

 91571 338. 354. 355. 371. 370.

 91575 383. 391. 417. 438. 443.

 91600 400. 409. 424. 438. 447.

 91603 378. 375. 388. 402. 415.

 91604 382. 390. 393. 408. 432.

 91605 348. 353. 364. 388. 399.

 91612 360. 348. 358. 379. 394.

 91618 368. 370. 373. 388. 406.

 91619 356. 364. 378. 391. 410.

 MEAN 370. 375. 387. 404. 418.

 S.D. 18.6 19.1 23.3 23.6 24.9

 S.E. 5.4 5.5 6.7 6.8 7.2

 N 12 12 12 12 12

 PJTBWv4.27

 11/25/2013

Page 547 of 1107
 TABLE A10 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 0- 7 7- 13 13- 21 21- 28 0- 13 0- 28

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 1: 0 PPM

-------------------------------------------

 91555 15. 23. 12. 27. 38. 76.

 91560 22. 21. 25. 27. 43. 95.

 91562 13. 9. 16. 23. 21. 59.

 91563 17. 17. 8. 18. 35. 61.

 91564 7. 21. 6. 13. 29. 47.

 91567 15. 10. 12. 28. 24. 64.

 91579 9. 24. 28. 23. 33. 83.

 91586 9. 27. 36. 22. 36. 94.

 91591 14. 14. 17. 26. 28. 72.

 91592 22. 30. 22. 22. 53. 97.

 91609 17. 25. 18. 22. 42. 82.

 91615 32. 21. 11. 39. 53. 103.

 MEAN 16. 20. 18. 24. 36. 78.

 S.D. 6.8 6.7 8.9 6.4 10.1 17.5

 S.E. 2.0 1.9 2.6 1.8 2.9 5.0

 N 12 12 12 12 12 12

Page 548 of 1107
 TABLE A10 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 0- 7 7- 13 13- 21 21- 28 0- 13 0- 28

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 2: 50 PPM

-------------------------------------------

 91556 29. 19. 21. 16. 48. 86.

 91559 4. 14. 16. 18. 18. 52.

 91561 34. 34. 24. 18. 69. 111.

 91566 17. 18. 15. 19. 36. 69.

 91576 12. 23. 9. 15. 35. 58.

 91582 14. 27. 23. 36. 41. 99.

 91585 34. 21. 23. 24. 55. 102.

 91589 11. 27. 15. 18. 38. 71.

 91593 19. 26. 16. 19. 44. 79.

 91594 18. 27. 18. 16. 45. 79.

 91595 26. 24. 22. 23. 50. 95.

 91602 28. 27. 33. 19. 55. 107.

 MEAN 20. 24. 20. 20. 44. 84.

 S.D. 9.7 5.3 6.2 5.5 12.8 19.1

 S.E. 2.8 1.5 1.8 1.6 3.7 5.5

 N 12 12 12 12 12 12

Page 549 of 1107
 TABLE A10 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 0- 7 7- 13 13- 21 21- 28 0- 13 0- 28

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 3: 100 PPM

-------------------------------------------

 91569 1. 20. 20. 21. 21. 62.

 91573 15. 2. 11. 23. 17. 51.

 91577 13. 19. 11. 16. 33. 59.

 91581 -15. -2. 32. 14. -18. 29.

 91583 6. 8. 15. 1. 14. 30.

 91588 12. 17. 13. 23. 28. 65.

 91590 11. 24. 13. 13. 35. 61.

 91598 25. 11. 9. 10. 36. 56.

 91599 18. 22. 9. 17. 39. 66.

 91608 20. 23. 16. 20. 44. 80.

 91611 22. 14. 11. 8. 37. 55.

 91616 12. 28. 5. 28. 40. 73.

 MEAN 12. 16. 14. 16. 27. 57.

 S.D. 10.8 9.2 6.9 7.6 16.9 15.1

 S.E. 3.1 2.7 2.0 2.2 4.9 4.3

 N 12 12 12 12 12 12

Page 550 of 1107
 TABLE A10 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 0- 7 7- 13 13- 21 21- 28 0- 13 0- 28

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 4: 175 PPM

-------------------------------------------

 91565 6. 21. 23. 11. 26. 60.

 91568 28. 10. 4. -2. 38. 39.

 91570 17. 27. 5. 5. 45. 55.

 91572 -3. 18. 18. 17. 15. 50.

 91580 19. 21. 16. 7. 40. 63.

 91584 10. 27. 13. 10. 37. 60.

 91587 38. 31. 24. 22. 69. 114.

 91597 17. 14. 21. 18. 30. 70.

 91601 15. 24. 19. 20. 38. 77.

 91607 0. 20. 32. 32. 20. 84.

 91613 -5. 29. 30. 12. 24. 66.

 91614 27. 28. 0. 30. 55. 85.

 MEAN 14. 22. 17. 15. 36. 68.

 S.D. 13.2 6.3 10.1 9.9 15.1 19.7

 S.E. 3.8 1.8 2.9 2.9 4.3 5.7

 N 12 12 12 12 12 12

Page 551 of 1107
 TABLE A10 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 0- 7 7- 13 13- 21 21- 28 0- 13 0- 28

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 5: 10000 PPM

-------------------------------------------

 91554 14. 11. 18. 15. 25. 58.

 91557 12. 14. 29. 18. 26. 74.

 91558 -4. 23. 4. 15. 19. 37.

 91571 16. 2. 16. -1. 17. 33.

 91575 8. 26. 21. 5. 34. 60.

 91600 9. 16. 14. 9. 24. 48.

 91603 -3. 12. 15. 13. 9. 37.

 91604 8. 2. 16. 23. 10. 50.

 91605 5. 11. 24. 11. 16. 51.

 91612 -12. 10. 21. 15. -2. 34.

 91618 1. 3. 15. 17. 5. 37.

 91619 8. 13. 13. 19. 22. 54.

 MEAN 5. 12. 17. 13. 17. 48.

 S.D. 8.0 7.5 6.4 6.6 10.1 12.4

 S.E. 2.3 2.2 1.8 1.9 2.9 3.6

 N 12 12 12 12 12 12

 PJTBWv4.27

 11/25/2013

Page 552 of 1107
 TABLE A11 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 0 7 13 21 27 35 42 49

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 1: 0 PPM

-------------------------------------------

 91629 241. 240. 238. NA NA NA NA

 91630 246. 262. 261. NA NA NA NA

 91633 273. 283. 299. NA NA NA

 91637 237. 254. 268. NA NA NA

 91639 264. 276. 288. NA NA NA NA

 91644 240. 245. 266. NA NA NA

 91645 265. 277. 284. NA NA NA NA

 91648 258. 264. 281. NA NA NA

 91653 250. 253. 278. NA NA NA NA

 91660 239. 281. 285. NA NA NA NA

 91670 253. 269. 274. NA NA NA NA

 91672 255. 282. 289. NA NA NA NA

 MEAN 252. 265. 276. NA NA NA NA

 S.D. 11.7 14.7 16.1

 S.E. 3.4 4.2 4.7

 N 12 12 12

NA = NOT APPLICABLE

Page 553 of 1107
 TABLE A11 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 0 7 13 21 27 35 42 49

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 2: 50 PPM

-------------------------------------------

 91632 245. 272. 279. NA NA NA NA

 91640 264. 280. 286. NA NA NA NA

 91642 253. 271. 288. NA NA NA

 91647 228. 244. 241. NA NA NA NA

 91651 254. 275. 284. NA NA NA NA

 91659 263. 277. 304. NA NA NA

 91661 241. 254. 271. NA NA NA

 91663 228. 238. 282. NA NA NA NA

 91669 245. 264. 286. NA NA NA

 91673 260. 270. 273. NA NA NA NA

 91683 235. 252. 256. NA NA NA NA

 91685 236. 249. 254. NA NA NA

 MEAN 246. 262. 275. NA NA NA NA

 S.D. 12.8 14.3 17.6

 S.E. 3.7 4.1 5.1

 N 12 12 12

NA = NOT APPLICABLE

Page 554 of 1107
 TABLE A11 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 0 7 13 21 27 35 42 49

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 3: 100 PPM

-------------------------------------------

 91620 248. 266. 293. NA NA NA NA

 91628 232. 237. 250. NA NA NA

 91631 256. 276. 297. NA NA NA

 91636 230. 235. 261. NA NA NA NA

 91649 220. 240. 248. NA NA NA

 91650 246. 269. 277. NA NA NA

 91656 259. 272. 301. NA NA NA NA

 91671 235. 267. 280. NA NA NA NA

 91675 261. 280. 288. NA NA NA

 91677 224. 255. 274. NA NA NA NA

 91679 264. 283. 295. NA NA NA

 91684 240. 258. 269. NA NA NA

 MEAN 243. 261. 278. NA NA NA NA

 S.D. 15.1 16.6 18.1

 S.E. 4.4 4.8 5.2

 N 12 12 12

NA = NOT APPLICABLE

Page 555 of 1107
 TABLE A11 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 0 7 13 21 27 35 42 49

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 4: 175 PPM

-------------------------------------------

 91622 250. 246. 257. NA NA NA

 91623 255. 261. 274. 297. 313. 318. 313. 320.

 91626 263. 272. 293. NA NA NA NA

 91643 261. 271. 289. NA NA NA NA

 91654 238. 246. 270. NA NA NA NA

 91657 268. 275. 295. 325. NA NA NA NA

 91662 255. 267. 293. NA NA NA NA

 91666 226. 242. 256. NA NA NA

 91676 221. 243. 259. NA NA NA NA

 91678 263. 299. 317. NA NA NA

 91681 251. 265. 286. 300. NA NA NA NA

 91682 269. 283. 299. NA NA NA NA

 MEAN 252. 264. 282. 307. 313. 318. 313. 320.

 S.D. 15.8 17.6 19.0 15.2 0.0 0.0 0.0 0.0

 S.E. 4.6 5.1 5.5 8.8 0.0 0.0 0.0 0.0

 N 12 12 12 3 1 1 1 1

NA = NOT APPLICABLE

Page 556 of 1107
 TABLE A11 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 0 7 13 21 27 35 42 49

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 5: 10000 PPM

-------------------------------------------

 91624 228. 248. 269. NA NA NA NA

 91625 239. 244. 257. NA NA NA NA

 91627 251. 251. 256. NA NA NA

 91634 238. 249. 262. NA NA NA NA

 91635 268. 275. 283. NA NA NA

 91638 242. 260. 270. NA NA NA NA

 91652 241. 250. 265. NA NA NA

 91655 239. 251. 265. NA NA NA

 91658 239. 266. 273. NA NA NA

 91667 272. 277. 286. NA NA NA

 91668 249. 255. 271. NA NA NA

 91680 243. 261. 266. NA NA NA

 MEAN 246. 257. 269. NA NA NA NA

 S.D. 12.8 10.6 9.1

 S.E. 3.7 3.1 2.6

 N 12 12 12

NA = NOT APPLICABLE

 PJTBWv4.27

 01/07/2014

Page 557 of 1107
 TABLE A12 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 0- 7 7- 13 13- 21 21- 27 27- 35 35- 42 42- 49 0- 13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 1: 0 PPM

-------------------------------------------

 91629 -1. -2. NA NA NA NA -3.

 91630 16. -1. NA NA NA NA 16.

 91633 10. 17. NA NA NA 26.

 91637 17. 14. NA NA NA 31.

 91639 12. 12. NA NA NA NA 24.

 91644 6. 20. NA NA NA 26.

 91645 12. 7. NA NA NA NA 19.

 91648 6. 16. NA NA NA 22.

 91653 4. 25. NA NA NA NA 29.

 91660 42. 4. NA NA NA NA 46.

 91670 15. 5. NA NA NA NA 21.

 91672 27. 8. NA NA NA NA 34.

 MEAN 14. 10. NA NA NA NA 24.

 S.D. 11.4 8.3 11.7

 S.E. 3.3 2.4 3.4

 N 12 12 12

NA = NOT APPLICABLE

Page 558 of 1107
 TABLE A12 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 0- 7 7- 13 13- 21 21- 27 27- 35 35- 42 42- 49 0- 13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 2: 50 PPM

-------------------------------------------

 91632 27. 7. NA NA NA NA 34.

 91640 16. 6. NA NA NA NA 22.

 91642 18. 16. NA NA NA 34.

 91647 16. -3. NA NA NA NA 13.

 91651 22. 9. NA NA NA NA 31.

 91659 14. 27. NA NA NA 42.

 91661 13. 17. NA NA NA 30.

 91663 9. 44. NA NA NA NA 54.

 91669 19. 22. NA NA NA 41.

 91673 10. 3. NA NA NA NA 13.

 91683 18. 3. NA NA NA NA 21.

 91685 12. 6. NA NA NA 18.

 MEAN 16. 13. NA NA NA NA 29.

 S.D. 5.1 13.1 12.5

 S.E. 1.5 3.8 3.6

 N 12 12 12

NA = NOT APPLICABLE

Page 559 of 1107
 TABLE A12 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 0- 7 7- 13 13- 21 21- 27 27- 35 35- 42 42- 49 0- 13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 3: 100 PPM

-------------------------------------------

 91620 18. 27. NA NA NA NA 45.

 91628 5. 13. NA NA NA 18.

 91631 20. 22. NA NA NA 41.

 91636 5. 26. NA NA NA NA 31.

 91649 20. 8. NA NA NA 28.

 91650 23. 9. NA NA NA 31.

 91656 13. 29. NA NA NA NA 41.

 91671 31. 14. NA NA NA NA 45.

 91675 19. 8. NA NA NA 27.

 91677 31. 19. NA NA NA NA 50.

 91679 19. 13. NA NA NA 31.

 91684 18. 10. NA NA NA 28.

 MEAN 18. 16. NA NA NA NA 35.

 S.D. 8.2 7.8 9.4

 S.E. 2.4 2.2 2.7

 N 12 12 12

NA = NOT APPLICABLE

Page 560 of 1107
 TABLE A12 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 0- 7 7- 13 13- 21 21- 27 27- 35 35- 42 42- 49 0- 13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 4: 175 PPM

-------------------------------------------

 91622 -4. 11. NA NA NA 7.

 91623 5. 14. 23. 16. 5. -5. 7. 19.

 91626 9. 21. NA NA NA NA 30.

 91643 11. 17. NA NA NA NA 28.

 91654 8. 24. NA NA NA NA 32.

 91657 8. 20. 30. NA NA NA NA 27.

 91662 12. 26. NA NA NA NA 38.

 91666 17. 14. NA NA NA 31.

 91676 22. 17. NA NA NA NA 39.

 91678 36. 18. NA NA NA 54.

 91681 14. 21. 15. NA NA NA NA 35.

 91682 14. 16. NA NA NA NA 30.

 MEAN 12. 18. 22. 16. 5. -5. 7. 31.

 S.D. 9.6 4.4 7.5 0.0 0.0 0.0 0.0 11.1

 S.E. 2.8 1.3 4.3 0.0 0.0 0.0 0.0 3.2

 N 12 12 3 1 1 1 1 12

NA = NOT APPLICABLE

Page 561 of 1107
 TABLE A12 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 0- 7 7- 13 13- 21 21- 27 27- 35 35- 42 42- 49 0- 13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 5: 10000 PPM

-------------------------------------------

 91624 20. 21. NA NA NA NA 41.

 91625 6. 13. NA NA NA NA 18.

 91627 0. 5. NA NA NA 5.

 91634 12. 13. NA NA NA NA 25.

 91635 7. 8. NA NA NA 15.

 91638 18. 10. NA NA NA NA 28.

 91652 10. 15. NA NA NA 24.

 91655 13. 13. NA NA NA 26.

 91658 27. 7. NA NA NA 34.

 91667 5. 9. NA NA NA 14.

 91668 6. 16. NA NA NA 22.

 91680 19. 4. NA NA NA 23.

 MEAN 12. 11. NA NA NA NA 23.

 S.D. 7.8 4.9 9.5

 S.E. 2.3 1.4 2.7

 N 12 12 12

NA = NOT APPLICABLE

 PJTBWv4.27

 01/07/2014

Page 562 of 1107
 TABLE A13 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS DURING GESTATION [G]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 0 4 7 11 14 17 20

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91629 G 250. 274. 281. 299. 316. 346. 387.

 91630 G 261. 290. 308. 324. 343. 378. 424.

 91633 G 289. 311. 323. 353. 368. 404. 446.

 91637 G 265. 283. 293. 313. 328. 358. 392.

 91639 G 289. 304. 321. 339. 364. 387. 419.

 91644 G 253. 289. 296. 321. 337. 374. 415.

 91645 G 293. 315. 327. 341. 357. 388. 433.

 91648 G 279. 312. 333. 358. 380. 415. 464.

 91653 G 262. 299. 304. 323. 348. 375. 418.

 91660 G 292. 313. 323. 342. 361. 389. 428.

 91670 G 288. 305. 320. 339. 355. 386. 428.

 91672 G 305. 334. 344. 375. 385. 425. 475.

 MEAN 277. 302. 314. 336. 354. 385. 427.

 S.D. 18.1 16.4 18.3 20.9 20.3 22.2 25.6

 S.E. 5.2 4.7 5.3 6.0 5.9 6.4 7.4

 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 563 of 1107
 TABLE A13 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS DURING GESTATION [G]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 0 4 7 11 14 17 20

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91632 G 292. 309. 319. 335. 352. 382. 425.

 91640 G 292. 313. 326. 341. 363. 387. 433.

 91642 G 283. 308. 321. 340. 360. 395. 444.

 91647 G 250. 274. 283. 301. 319. 339. 388.

 91651 G 280. 299. 315. 327. 341. 372. 415.

 91659 G 299. 319. 338. 363. 371. 412. 466.

 91661 G 278. 298. 309. 324. 341. 385. 427.

 91663 G 278. 305. 326. 340. 352. 387. 438.

 91669 G 270. 303. 313. 339. 347. 380. 438.

 91673 G 281. 301. 315. 332. 343. 381. 438.

 91683 G 263. 298. 308. 329. 343. 359. 404.

 91685 G 250. 279. 292. 314. 322. 352. 388.

 MEAN 276. 301. 314. 332. 346. 378. 425.

 S.D. 15.7 12.9 14.9 15.4 15.2 19.7 23.1

 S.E. 4.5 3.7 4.3 4.4 4.4 5.7 6.7

 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 564 of 1107
 TABLE A13 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS DURING GESTATION [G]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 0 4 7 11 14 17 20

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91620 G 292. 317. 333. 351. 367. 396. 445.

 91628 G 251. 272. 280. 297. 314. 350. 403.

 91631 G 293. 319. 332. 360. 374. 414. 461.

 91636 G 244. 283. 294. 308. 323. 352. 394.

 91649 G 255. 274. 283. 309. 321. 360. 422.

 91650 G 276. 295. 316. 339. 355. 386. 443.

 91656 G 313. 324. 325. 345. 359. 389. 432.

 91671 G 303. 328. 343. 354. 372. 399. 459.

 91675 G 288. 319. 328. 348. 360. 392. 441.

 91677 G 276. 294. 314. 316. 333. 351. 367.

 91679 G 293. 320. 334. 348. 372. 394. 440.

 91684 G 269. 277. 285. 310. 321. 355. 413.

 MEAN 279. 302. 314. 332. 348. 378. 427.

 S.D. 21.5 21.5 22.6 22.2 23.3 22.8 28.0

 S.E. 6.2 6.2 6.5 6.4 6.7 6.6 8.1

 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 565 of 1107
 TABLE A13 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS DURING GESTATION [G]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 0 4 7 11 14 17 20

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 4: 175 PPM

---------------------------------------

 91622 G 253. 280. 287. 306. 320. 348. 397.

 91626 G 291. 311. 322. 339. 356. 387. 444.

 91643 G 310. 319. 331. 359. 367. 407. 456.

 91654 G 279. 298. 310. 324. 338. 371. 428.

 91657 G 325. 335. 348. 367. 377. 417. 461.

 91662 G 295. 311. 322. 336. 344. 370. 426.

 91666 G 249. 269. 273. 296. 305. 333. 370.

 91676 G 256. 274. 290. 311. 323. 353. 401.

 91678 G 324. 341. 368. 391. 402. 429. 479.

 91681 G 292. 304. 315. 334. 342. 373. 434.

 91682 G 305. 320. 333. 350. 366. 389. 438.

 MEAN 289. 306. 318. 338. 349. 380. 430.

 S.D. 27.1 23.7 27.7 28.2 28.1 29.7 31.4

 S.E. 8.2 7.1 8.3 8.5 8.5 9.0 9.5

 N 11 11 11 11 11 11 11

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 566 of 1107
 TABLE A13 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS DURING GESTATION [G]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 0 4 7 11 14 17 20

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91624 G 263. 294. 307. 321. 329. 367. 408.

 91625 G 256. 273. 281. 299. 313. 338. 387.

 91627 G 268. 279. 287. 303. 312. 347. 394.

 91634 G 265. 287. 303. 318. 337. 363. 408.

 91635 G 271. 296. 307. 330. 345. 383. 428.

 91638 G 279. 304. 313. 331. 344. 371. 421.

 91652 G 264. 303. 318. 351. 364. 391. 445.

 91655 G 258. 289. 299. 316. 328. 365. 415.

 91658 G 275. 294. 302. 322. 335. 358. 399.

 91667 G 285. 305. 314. 333. 346. 390. 426.

 91668 G 275. 297. 313. 337. 356. 394. 441.

 91680 G 267. 287. 289. 312. 326. 360. 410.

 MEAN 269. 292. 303. 323. 336. 369. 415.

 S.D. 8.5 9.9 11.8 14.7 15.8 17.7 17.9

 S.E. 2.5 2.8 3.4 4.2 4.6 5.1 5.2

 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

 PGBWv4.09

 01/07/2014

Page 567 of 1107
 TABLE A14 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES DURING GESTATION [G]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 0- 4 4- 7 7- 11 11- 14 14- 17 17- 20 0- 20

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91629 G 24. 7. 18. 17. 30. 41. 137.

 91630 G 29. 18. 16. 19. 35. 46. 163.

 91633 G 22. 12. 30. 15. 36. 42. 157.

 91637 G 18. 10. 20. 15. 30. 34. 127.

 91639 G 15. 17. 18. 25. 23. 32. 130.

 91644 G 36. 7. 25. 16. 37. 41. 162.

 91645 G 22. 12. 14. 16. 31. 45. 140.

 91648 G 33. 21. 25. 22. 35. 49. 185.

 91653 G 37. 5. 19. 25. 27. 43. 156.

 91660 G 21. 10. 19. 19. 28. 39. 136.

 91670 G 17. 15. 19. 16. 31. 42. 140.

 91672 G 29. 10. 31. 10. 40. 50. 170.

 MEAN 25. 12. 21. 18. 32. 42. 150.

 S.D. 7.4 4.9 5.4 4.4 4.8 5.3 17.9

 S.E. 2.1 1.4 1.6 1.3 1.4 1.5 5.2

 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 568 of 1107
 TABLE A14 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES DURING GESTATION [G]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 0- 4 4- 7 7- 11 11- 14 14- 17 17- 20 0- 20

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91632 G 17. 10. 16. 17. 30. 43. 133.

 91640 G 21. 13. 15. 22. 24. 46. 141.

 91642 G 25. 13. 19. 20. 35. 49. 161.

 91647 G 24. 9. 18. 18. 20. 49. 138.

 91651 G 19. 16. 12. 14. 31. 43. 135.

 91659 G 20. 19. 25. 8. 41. 54. 167.

 91661 G 20. 11. 15. 17. 44. 42. 149.

 91663 G 27. 21. 14. 12. 35. 51. 160.

 91669 G 33. 10. 26. 8. 33. 58. 168.

 91673 G 20. 14. 17. 11. 38. 57. 157.

 91683 G 35. 10. 21. 14. 16. 45. 141.

 91685 G 29. 13. 22. 8. 30. 36. 138.

 MEAN 24. 13. 18. 14. 31. 48. 149.

 S.D. 5.8 3.8 4.4 4.8 8.3 6.5 12.9

 S.E. 1.7 1.1 1.3 1.4 2.4 1.9 3.7

 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 569 of 1107
 TABLE A14 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES DURING GESTATION [G]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 0- 4 4- 7 7- 11 11- 14 14- 17 17- 20 0- 20

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91620 G 25. 16. 18. 16. 29. 49. 153.

 91628 G 21. 8. 17. 17. 36. 53. 152.

 91631 G 26. 13. 28. 14. 40. 47. 168.

 91636 G 39. 11. 14. 15. 29. 42. 150.

 91649 G 19. 9. 26. 12. 39. 62. 167.

 91650 G 19. 21. 23. 16. 31. 57. 167.

 91656 G 11. 1. 20. 14. 30. 43. 119.

 91671 G 25. 15. 11. 18. 27. 60. 156.

 91675 G 31. 9. 20. 12. 32. 49. 153.

 91677 G 18. 20. 2. 17. 18. 16. 91.

 91679 G 27. 14. 14. 24. 22. 46. 147.

 91684 G 8. 8. 25. 11. 34. 58. 144.

 MEAN 22. 12. 18. 16. 31. 49. 147.

 S.D. 8.4 5.6 7.3 3.5 6.4 12.2 22.1

 S.E. 2.4 1.6 2.1 1.0 1.9 3.5 6.4

 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 570 of 1107
 TABLE A14 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES DURING GESTATION [G]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 0- 4 4- 7 7- 11 11- 14 14- 17 17- 20 0- 20

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 4: 175 PPM

---------------------------------------

 91622 G 27. 7. 19. 14. 28. 49. 144.

 91626 G 20. 11. 17. 17. 31. 57. 153.

 91643 G 9. 12. 28. 8. 40. 49. 146.

 91654 G 19. 12. 14. 14. 33. 57. 149.

 91657 G 10. 13. 19. 10. 40. 44. 136.

 91662 G 16. 11. 14. 8. 26. 56. 131.

 91666 G 20. 4. 23. 9. 28. 37. 121.

 91676 G 18. 16. 21. 12. 30. 48. 145.

 91678 G 17. 27. 23. 11. 27. 50. 155.

 91681 G 12. 11. 19. 8. 31. 61. 142.

 91682 G 15. 13. 17. 16. 23. 49. 133.

 MEAN 17. 12. 19. 12. 31. 51. 141.

 S.D. 5.1 5.8 4.2 3.3 5.4 6.8 10.2

 S.E. 1.6 1.7 1.3 1.0 1.6 2.1 3.1

 N 11 11 11 11 11 11 11

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 571 of 1107
 TABLE A14 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES DURING GESTATION [G]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 0- 4 4- 7 7- 11 11- 14 14- 17 17- 20 0- 20

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91624 G 31. 13. 14. 8. 38. 41. 145.

 91625 G 17. 8. 18. 14. 25. 49. 131.

 91627 G 11. 8. 16. 9. 35. 47. 126.

 91634 G 22. 16. 15. 19. 26. 45. 143.

 91635 G 25. 11. 23. 15. 38. 45. 157.

 91638 G 25. 9. 18. 13. 27. 50. 142.

 91652 G 39. 15. 33. 13. 27. 54. 181.

 91655 G 31. 10. 17. 12. 37. 50. 157.

 91658 G 19. 8. 20. 13. 23. 41. 124.

 91667 G 20. 9. 19. 13. 44. 36. 141.

 91668 G 22. 16. 24. 19. 38. 47. 166.

 91680 G 20. 2. 23. 14. 34. 50. 143.

 MEAN 24. 10. 20. 14. 33. 46. 146.

 S.D. 7.4 4.1 5.2 3.3 6.7 5.0 16.6

 S.E. 2.1 1.2 1.5 0.9 1.9 1.4 4.8

 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

 PGBWv4.09

 01/07/2014

Page 572 of 1107
 TABLE A15 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS DURING LACTATION [G]

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91629 279. 308.

 91630 307. 324.

 91633 344. 361.

 91637 295. 320.

 91639 349. 361.

 91644 296. 313.

 91645 334. 342.

 91648 357. 359.

 91653 319. 347.

 91660 328. 368.

 91670 335. 332.

 91672 374. 374.

 MEAN 326. 342.

 S.D. 28.2 22.6

 S.E. 8.1 6.5

 N 12 12

Page 573 of 1107
 TABLE A15 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS DURING LACTATION [G]

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91632 302. 321.

 91640 341. 362.

 91642 338. 349.

 91647 285. 296.

 91651 322. 329.

 91659 357. 371.

 91661 306. 315.

 91663 330. 324.

 91669 284. 325.

 91673 319. 321.

 91683 319. 321.

 91685 287. 292.

 MEAN 316. 327.

 S.D. 23.7 23.5

 S.E. 6.8 6.8

 N 12 12

Page 574 of 1107
 TABLE A15 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS DURING LACTATION [G]

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91620 343. 351.

 91628 271. 289.

 91631 347. 351.

 91636 294. 289.

 91649 294. 305.

 91650 339. 355.

 91656 326. 330.

 91671 332. 346.

 91675 343. 359.

 91677 307. 309.

 91679 327. 338.

 91684 285. 286.

 MEAN 317. 326.

 S.D. 26.0 28.3

 S.E. 7.5 8.2

 N 12 12

Page 575 of 1107
 TABLE A15 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS DURING LACTATION [G]

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 4: 175 PPM

---------------------------------------

 91622 285. 301.

 91626 335. 367.

 91643 346. 360.

 91654 316. NA

 91657 356. 354.

 91662 332. 330.

 91666 278. 285.

 91676 313. 317.

 91678 378. 396.

 91681 319. 320.

 91682 330. 338.

 MEAN 326. 337.

 S.D. 29.1 33.2

 S.E. 8.8 10.5

 N 11 10

NA = NOT APPLICABLE

Page 576 of 1107
 TABLE A15 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHTS DURING LACTATION [G]

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91624 326. 321.

 91625 278. 293.

 91627 298. 303.

 91634 307. 331.

 91635 309. 338.

 91638 303. 319.

 91652 345. 355.

 91655 303. 317.

 91658 291. 325.

 91667 321. 348.

 91668 318. 342.

 91680 284. 325.

 MEAN 307. 326.

 S.D. 18.7 17.9

 S.E. 5.4 5.2

 N 12 12

 PLBWv4.09

 01/07/2014

Page 577 of 1107
 TABLE A16 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES DURING LACTATION [G]

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91629 29.

 91630 17.

 91633 17.

 91637 25.

 91639 12.

 91644 17.

 91645 8.

 91648 2.

 91653 28.

 91660 40.

 91670 -3.

 91672 0.

 MEAN 16.

 S.D. 13.0

 S.E. 3.8

 N 12

Page 578 of 1107
 TABLE A16 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES DURING LACTATION [G]

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91632 19.

 91640 21.

 91642 11.

 91647 11.

 91651 7.

 91659 14.

 91661 9.

 91663 -6.

 91669 41.

 91673 2.

 91683 2.

 91685 5.

 MEAN 11.

 S.D. 12.0

 S.E. 3.5

 N 12

Page 579 of 1107
 TABLE A16 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES DURING LACTATION [G]

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91620 8.

 91628 18.

 91631 4.

 91636 -5.

 91649 11.

 91650 16.

 91656 4.

 91671 14.

 91675 16.

 91677 2.

 91679 11.

 91684 1.

 MEAN 8.

 S.D. 7.2

 S.E. 2.1

 N 12

Page 580 of 1107
 TABLE A16 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES DURING LACTATION [G]

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 4: 175 PPM

---------------------------------------

 91622 16.

 91626 32.

 91643 14.

 91657 -2.

 91662 -2.

 91666 7.

 91676 4.

 91678 18.

 91681 1.

 91682 8.

 MEAN 10.

 S.D. 10.6

 S.E. 3.4

 N 10

NA = NOT APPLICABLE

Page 581 of 1107
 TABLE A16 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL BODY WEIGHT CHANGES DURING LACTATION [G]

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91624 -5.

 91625 15.

 91627 5.

 91634 24.

 91635 29.

 91638 16.

 91652 10.

 91655 14.

 91658 34.

 91667 27.

 91668 24.

 91680 41.

 MEAN 20.

 S.D. 12.9

 S.E. 3.7

 N 12

 PLBWv4.09

 01/07/2014

Page 582 of 1107
 TABLE A17 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 0- 7 7- 13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 1: 0 PPM

-------------------------------------------

 91555 24. 25.

 91560 26. 26.

 91562 20. 22.

 91563 24. 22.

 91564 22. 22.

 91567 24. 22.

 91579 24. 25.

 91586 24. 23.

 91591 25. 22.

 91592 26. 25.

 91609 23. 24.

 91615 25. 24.

 MEAN 24. 23.

 S.D. 1.6 1.4

 S.E. 0.5 0.4

 N 12 12

Page 583 of 1107
 TABLE A17 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 0- 7 7- 13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 2: 50 PPM

-------------------------------------------

 91556 23. 23.

 91559 21. 20.

 91561 23. 25.

 91566 24. 22.

 91576 22. 23.

 91582 29. 27.

 91585 25. 25.

 91589 20. 21.

 91593 24. 24.

 91594 23. 24.

 91595 27. 26.

 91602 25. 27.

 MEAN 24. 24.

 S.D. 2.4 2.3

 S.E. 0.7 0.7

 N 12 12

Page 584 of 1107
 TABLE A17 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 0- 7 7- 13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 3: 100 PPM

-------------------------------------------

 91569 19. 21.

 91573 23. 19.

 91577 23. 22.

 91581 20. 18.

 91583 23. 20.

 91588 25. 24.

 91590 23. 23.

 91598 23. 21.

 91599 23. 23.

 91608 24. 23.

 91611 23. 23.

 91616 24. 24.

 MEAN 23. 22.

 S.D. 1.7 1.9

 S.E. 0.5 0.5

 N 12 12

Page 585 of 1107
 TABLE A17 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 0- 7 7- 13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 4: 175 PPM

-------------------------------------------

 91565 20. 20.

 91568 24. 24.

 91570 22. 22.

 91572 19. 21.

 91580 21. 21.

 91584 23. 23.

 91587 25. 25.

 91597 24. 23.

 91601 20. 22.

 91607 22. 21.

 91613 22. 24.

 91614 26. 27.

 MEAN 22. 23.

 S.D. 2.2 1.9

 S.E. 0.6 0.6

 N 12 12

Page 586 of 1107
 TABLE A17 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 0- 7 7- 13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 5: 10000 PPM

-------------------------------------------

 91554 22. 21.

 91557 23. 22.

 91558 21. 21.

 91571 22. 19.

 91575 23. 24.

 91600 24. 22.

 91603 22. 20.

 91604 22. 21.

 91605 20. 19.

 91612 19. 18.

 91618 21. 20.

 91619 23. 20.

 MEAN 22. 21.

 S.D. 1.4 1.7

 S.E. 0.4 0.5

 N 12 12

 PJTFWv4.26

 11/25/2013

Page 587 of 1107
 TABLE A18 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 0- 7 7- 13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 1: 0 PPM

-------------------------------------------

 91555 62. 60.

 91560 68. 64.

 91562 53. 57.

 91563 66. 59.

 91564 60. 57.

 91567 68. 60.

 91579 62. 61.

 91586 65. 60.

 91591 63. 54.

 91592 62. 58.

 91609 61. 61.

 91615 66. 58.

 MEAN 63. 59.

 S.D. 4.2 2.5

 S.E. 1.2 0.7

 N 12 12

Page 588 of 1107
 TABLE A18 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 0- 7 7- 13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 2: 50 PPM

-------------------------------------------

 91556 60. 57.

 91559 56. 51.

 91561 64. 64.

 91566 64. 57.

 91576 62. 61.

 91582 68. 62.

 91585 63. 58.

 91589 57. 56.

 91593 62. 59.

 91594 61. 59.

 91595 68. 61.

 91602 62. 62.

 MEAN 62. 59.

 S.D. 3.7 3.4

 S.E. 1.1 1.0

 N 12 12

Page 589 of 1107
 TABLE A18 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 0- 7 7- 13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 3: 100 PPM

-------------------------------------------

 91569 50. 55.

 91573 63. 50.

 91577 64. 58.

 91581 51. 46.

 91583 60. 53.

 91588 64. 58.

 91590 59. 55.

 91598 62. 55.

 91599 64. 61.

 91608 63. 57.

 91611 59. 54.

 91616 63. 60.

 MEAN 60. 55.

 S.D. 4.8 4.2

 S.E. 1.4 1.2

 N 12 12

Page 590 of 1107
 TABLE A18 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 0- 7 7- 13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 4: 175 PPM

-------------------------------------------

 91565 57. 55.

 91568 59. 54.

 91570 58. 55.

 91572 51. 55.

 91580 59. 56.

 91584 61. 58.

 91587 67. 62.

 91597 64. 58.

 91601 56. 59.

 91607 58. 54.

 91613 58. 60.

 91614 66. 64.

 MEAN 59. 58.

 S.D. 4.6 3.1

 S.E. 1.3 0.9

 N 12 12

Page 591 of 1107
 TABLE A18 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 0- 7 7- 13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 5: 10000 PPM

-------------------------------------------

 91554 61. 56.

 91557 59. 54.

 91558 55. 53.

 91571 63. 53.

 91575 59. 60.

 91600 60. 53.

 91603 59. 52.

 91604 56. 54.

 91605 56. 53.

 91612 54. 51.

 91618 58. 55.

 91619 63. 55.

 MEAN 59. 54.

 S.D. 2.9 2.4

 S.E. 0.8 0.7

 N 12 12

 PJTFWv4.26

 11/25/2013

Page 592 of 1107
FINAL REPORT

Contents: Volume 3 of 4 

Appendix G (continued)

Study Title: An Inhalation Reproduction/Developmental Toxicity

Screening Study of 2-Bromo-3,3,3-Trifluoropropene in Rats

Laboratory Project ID: WIL-65501

Author: Tammye L. Edwards, BS

Test Guideline: OECD Guideline 421

Study Completion Date: 21 March 2014

Performing Laboratory: WIL Research

1407 George Road

Ashland, OH 44805-8946

Sponsor: American Pacific Corporation

3883 Howard Hughes Parkway, Suite 700

Las Vegas, NV 89169

Total Number of Pages: 1107

 Page 593 of 1107
WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

APPENDIX G

Individual Animal Data (continued)

 Page 594 of 1107
 TABLE A19 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 0- 7 7- 13 13- 27 27- 35 35- 42 42- 49

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 1: 0 PPM

-------------------------------------------

 91629 15. 15. NA NA NA

 91630 16. 17. NA NA NA

 91633 19. 20. NA NA

 91637 19. 19. NA NA

 91639 19. 20. NA NA NA

 91644 17. 19. NA NA

 91645 19. 20. NA NA NA

 91648 17. 19. NA NA

 91653 18. 21. NA NA NA

 91660 20. 19. NA NA NA

 91670 20. 18. NA NA NA

 91672 21. 21. NA NA NA

 MEAN 18. 19. NA NA NA

 S.D. 1.8 1.6

 S.E. 0.5 0.5

 N 12 12

NA = NOT APPLICABLE

Page 595 of 1107
 TABLE A19 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 0- 7 7- 13 13- 27 27- 35 35- 42 42- 49

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 2: 50 PPM

-------------------------------------------

 91632 18. 18. NA NA NA

 91640 19. 17. NA NA NA

 91642 18. 19. NA NA

 91647 16. 15. NA NA NA

 91651 19. 17. NA NA NA

 91659 18. 21. NA NA

 91661 17. 18. NA NA

 91663 15. 20. NA NA NA

 91669 18. 20. NA NA

 91673 17. 18. NA NA NA

 91683 17. 17. NA NA NA

 91685 16. 17. NA NA

 MEAN 17. 18. NA NA NA

 S.D. 1.2 1.7

 S.E. 0.3 0.5

 N 12 12

NA = NOT APPLICABLE

Page 596 of 1107
 TABLE A19 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 0- 7 7- 13 13- 27 27- 35 35- 42 42- 49

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 3: 100 PPM

-------------------------------------------

 91620 18. 20. NA NA NA

 91628 14. 16. NA NA

 91631 18. 22. NA NA

 91636 14. 17. NA NA NA

 91649 16. 17. NA NA

 91650 19. 19. NA NA

 91656 17. 21. NA NA NA

 91671 19. 20. NA NA NA

 91675 18. 19. NA NA

 91677 18. 19. NA NA NA

 91679 19. 20. NA NA

 91684 16. 18. NA NA

 MEAN 17. 19. NA NA NA

 S.D. 1.9 1.8

 S.E. 0.5 0.5

 N 12 12

NA = NOT APPLICABLE

Page 597 of 1107
 TABLE A19 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 0- 7 7- 13 13- 27 27- 35 35- 42 42- 49

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 4: 175 PPM

-------------------------------------------

 91622 15. 16. NA NA

 91623 16. 17. NA 19. 16. 16.

 91626 17. 19. NA NA NA

 91643 18. 19. NA NA NA

 91654 18. 21. NA NA NA

 91657 17. 19. NA NA NA NA

 91662 18. 20. NA NA NA

 91666 15. 17. NA NA

 91676 16. 17. NA NA NA

 91678 13. 23. NA NA

 91681 17. 18. NA NA NA NA

 91682 18. 19. NA NA NA

 MEAN 17. 19. NA 19. 16. 16.

 S.D. 1.6 1.8 0.0 0.0 0.0

 S.E. 0.5 0.5 0.0 0.0 0.0

 N 12 12 1 1 1

NA = NOT APPLICABLE

Page 598 of 1107
 TABLE A19 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 0- 7 7- 13 13- 27 27- 35 35- 42 42- 49

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 5: 10000 PPM

-------------------------------------------

 91624 16. 18. NA NA NA

 91625 16. 16. NA NA NA

 91627 15. 16. NA NA

 91634 17. 17. NA NA NA

 91635 16. 17. NA NA

 91638 17. 19. NA NA NA

 91652 16. 19. NA NA

 91655 17. 18. NA NA

 91658 17. 18. NA NA

 91667 18. 19. NA NA

 91668 18. 19. NA NA

 91680 17. 17. NA NA

 MEAN 16. 18. NA NA NA

 S.D. 0.9 1.2

 S.E. 0.3 0.3

 N 12 12

NA = NOT APPLICABLE

 PJTFWv4.26

 01/07/2014

Page 599 of 1107
 TABLE A20 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 0- 7 7- 13 13- 27 27- 35 35- 42 42- 49

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 1: 0 PPM

-------------------------------------------

 91629 63. 62. NA NA NA

 91630 62. 66. NA NA NA

 91633 69. 69. NA NA

 91637 78. 73. NA NA

 91639 71. 71. NA NA NA

 91644 70. 74. NA NA

 91645 71. 70. NA NA NA

 91648 65. 70. NA NA

 91653 70. 78. NA NA NA

 91660 77. 68. NA NA NA

 91670 75. 68. NA NA NA

 91672 78. 73. NA NA NA

 MEAN 71. 70. NA NA NA

 S.D. 5.5 4.0

 S.E. 1.6 1.2

 N 12 12

NA = NOT APPLICABLE

Page 600 of 1107
 TABLE A20 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 0- 7 7- 13 13- 27 27- 35 35- 42 42- 49

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 2: 50 PPM

-------------------------------------------

 91632 69. 64. NA NA NA

 91640 68. 61. NA NA NA

 91642 69. 67. NA NA

 91647 67. 61. NA NA NA

 91651 71. 61. NA NA NA

 91659 66. 71. NA NA

 91661 70. 68. NA NA

 91663 64. 78. NA NA NA

 91669 70. 73. NA NA

 91673 65. 66. NA NA NA

 91683 70. 68. NA NA NA

 91685 67. 68. NA NA

 MEAN 68. 67. NA NA NA

 S.D. 2.3 5.1

 S.E. 0.7 1.5

 N 12 12

NA = NOT APPLICABLE

Page 601 of 1107
 TABLE A20 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 0- 7 7- 13 13- 27 27- 35 35- 42 42- 49

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 3: 100 PPM

-------------------------------------------

 91620 69. 71. NA NA NA

 91628 59. 64. NA NA

 91631 69. 76. NA NA

 91636 59. 70. NA NA NA

 91649 68. 70. NA NA

 91650 72. 71. NA NA

 91656 66. 73. NA NA NA

 91671 75. 73. NA NA NA

 91675 68. 67. NA NA

 91677 74. 73. NA NA NA

 91679 70. 68. NA NA

 91684 65. 66. NA NA

 MEAN 68. 70. NA NA NA

 S.D. 5.1 3.4

 S.E. 1.5 1.0

 N 12 12

NA = NOT APPLICABLE

Page 602 of 1107
 TABLE A20 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 0- 7 7- 13 13- 27 27- 35 35- 42 42- 49

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 4: 175 PPM

-------------------------------------------

 91622 59. 62. NA NA

 91623 60. 65. NA 60. 52. 51.

 91626 64. 67. NA NA NA

 91643 67. 67. NA NA NA

 91654 75. 80. NA NA NA

 91657 63. 67. NA NA NA NA

 91662 70. 70. NA NA NA

 91666 63. 69. NA NA

 91676 70. 69. NA NA NA

 91678 47. 73. NA NA

 91681 67. 66. NA NA NA NA

 91682 64. 66. NA NA NA

 MEAN 64. 68. NA 60. 52. 51.

 S.D. 7.0 4.6 0.0 0.0 0.0

 S.E. 2.0 1.3 0.0 0.0 0.0

 N 12 12 1 1 1

NA = NOT APPLICABLE

Page 603 of 1107
 TABLE A20 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 0- 7 7- 13 13- 27 27- 35 35- 42 42- 49

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 5: 10000 PPM

-------------------------------------------

 91624 66. 69. NA NA NA

 91625 65. 62. NA NA NA

 91627 58. 62. NA NA

 91634 70. 67. NA NA NA

 91635 60. 60. NA NA

 91638 67. 70. NA NA NA

 91652 64. 74. NA NA

 91655 68. 69. NA NA

 91658 65. 65. NA NA

 91667 65. 66. NA NA

 91668 70. 72. NA NA

 91680 66. 64. NA NA

 MEAN 65. 67. NA NA NA

 S.D. 3.5 4.3

 S.E. 1.0 1.2

 N 12 12

NA = NOT APPLICABLE

 PJTFWv4.26

 01/07/2014

Page 604 of 1107
 TABLE A21 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 0- 4 4- 7 7-11 11-14 14-17 17-20 0-20

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91629 G 20. 20. 20. 21. 23. 22. 21.

 91630 G 20. 23. 23. 23. 26. 25. 23.

 91633 G 17. 21. 25. 26. 28. 27. 24.

 91637 G 20. 20. 21. 23. 25. 23. 22.

 91639 G 19. 23. 24. 26. 26. 26. 24.

 91644 G 22. 22. 22. 23. 27. 26. 24.

 91645 G 20. 24. 25. 24. 23. 24. 23.

 91648 G 22. 26. 26. 28. 30. 29. 27.

 91653 G 22. 21. 23. 25. 24. 27. 24.

 91660 G 20. 20. 22. 22. 24. 23. 22.

 91670 G 19. 21. 25. 26. 27. 26. 24.

 91672 G 23. 26. 28. 27. 30. 29. 27.

 MEAN 20. 22. 24. 25. 26. 26. 24.

 S.D. 1.7 2.2 2.3 2.2 2.4 2.3 1.8

 S.E. 0.5 0.6 0.7 0.6 0.7 0.7 0.5

 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 605 of 1107
 TABLE A21 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 0- 4 4- 7 7-11 11-14 14-17 17-20 0-20

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91632 G 19. 20. 21. 23. 24. 24. 22.

 91640 G 19. 20. 21. 24. 27. 27. 23.

 91642 G 21. 23. 25. 24. 26. 29. 24.

 91647 G 17. 20. 19. 23. 22. 25. 21.

 91651 G 19. 21. 20. 22. 23. 24. 21.

 91659 G 19. 23. 25. 24. 29. 31. 25.

 91661 G 21. 24. 22. 24. 26. 24. 23.

 91663 G 22. 22. 25. 24. 26. 29. 24.

 91669 G 22. 24. 24. 23. 25. 27. 24.

 91673 G 18. 21. 22. 24. 27. 28. 23.

 91683 G 20. 22. 23. 24. 25. 25. 23.

 91685 G 21. 22. 24. 24. 25. 24. 23.

 MEAN 20. 22. 23. 24. 25. 26. 23.

 S.D. 1.6 1.5 2.1 0.7 1.9 2.4 1.2

 S.E. 0.5 0.4 0.6 0.2 0.5 0.7 0.3

 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 606 of 1107
 TABLE A21 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 0- 4 4- 7 7-11 11-14 14-17 17-20 0-20

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91620 G 22. 22. 24. 23. 25. 26. 23.

 91628 G 17. 18. 19. 20. 23. 24. 20.

 91631 G 22. 26. 25. 27. 31. 29. 26.

 91636 G 21. 21. 22. 21. 23. 24. 22.

 91649 G 20. 24. 22. 24. 25. 27. 23.

 91650 G 18. 22. 24. 26. 25. 28. 23.

 91656 G 18. 20. 20. 22. 23. 22. 21.

 91671 G 22. 26. 24. 25. 27. 29. 25.

 91675 G 19. 24. 23. 24. 29. 29. 24.

 91677 G 19. 23. 23. 20. 24. 24. 22.

 91679 G 19. 24. 25. 26. 26. 29. 24.

 91684 G 13. 19. 20. 20. 23. 24. 19.

 MEAN 19. 22. 23. 23. 25. 26. 23.

 S.D. 2.6 2.6 2.0 2.6 2.6 2.6 2.0

 S.E. 0.7 0.7 0.6 0.7 0.7 0.7 0.6

 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 607 of 1107
 TABLE A21 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 0- 4 4- 7 7-11 11-14 14-17 17-20 0-20

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 4: 175 PPM

---------------------------------------

 91622 G 16. 20. 19. 21. 23. 24. 20.

 91626 G 18. 21. 22. 24. 25. 28. 23.

 91643 G 17. 22. 23. 24. 29. 31. 24.

 91654 G 20. 22. 23. 22. 24. 29. 23.

 91657 G 17. 22. 22. 23. 27. 28. 23.

 91662 G 17. 22. 22. 21. 23. 25. 21.

 91666 G 16. 17. 19. 21. 22. 23. 19.

 91676 G 18. 22. 22. 23. 25. 28. 23.

 91678 G 21. 27. 29. 29. 27. 29. 27.

 91681 G 16. 18. 20. 21. 23. 26. 20.

 91682 G 20. 22. 22. 23. 24. 29. 23.

 MEAN 18. 21. 22. 23. 25. 27. 22.

 S.D. 1.8 2.6 2.7 2.3 2.1 2.5 2.2

 S.E. 0.5 0.8 0.8 0.7 0.6 0.7 0.7

 N 11 11 11 11 11 11 11

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 608 of 1107
 TABLE A21 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 0- 4 4- 7 7-11 11-14 14-17 17-20 0-20

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91624 G 19. 22. 22. 22. 26. 25. 22.

 91625 G 17. 19. 19. 20. 22. 22. 20.

 91627 G 15. 17. 19. 21. 24. 24. 20.

 91634 G 20. 22. 21. 22. 25. 27. 23.

 91635 G 16. 19. 20. 22. 24. 24. 20.

 91638 G 22. 23. 25. 23. 25. 25. 24.

 91652 G 23. 25. 26. 28. 30. 30. 27.

 91655 G 19. 22. 21. 23. 27. 28. 23.

 91658 G 16. 20. 21. 20. 21. 22. 20.

 91667 G 19. 21. 21. 21. 24. 22. 21.

 91668 G 21. 24. 23. 25. 27. 26. 24.

 91680 G 17. 17. 19. 22. 24. 25. 20.

 MEAN 19. 21. 21. 22. 25. 25. 22.

 S.D. 2.5 2.6 2.3 2.2 2.4 2.5 2.3

 S.E. 0.7 0.7 0.7 0.6 0.7 0.7 0.7

 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

 PGFWv4.11

 01/07/2014

Page 609 of 1107
 TABLE A22 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING GESTATION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 0- 4 4- 7 7-11 11-14 14-17 17-20 0-20

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91629 G 76. 72. 69. 68. 69. 60. 68.

 91630 G 72. 77. 73. 69. 72. 62. 69.

 91633 G 57. 66. 74. 72. 73. 64. 67.

 91637 G 73. 69. 69. 72. 73. 61. 69.

 91639 G 64. 73. 73. 74. 69. 65. 69.

 91644 G 81. 75. 71. 70. 76. 66. 74.

 91645 G 66. 75. 75. 69. 62. 58. 66.

 91648 G 74. 80. 75. 76. 75. 66. 74.

 91653 G 78. 70. 73. 74. 66. 68. 72.

 91660 G 66. 63. 66. 63. 64. 56. 63.

 91670 G 64. 67. 76. 75. 73. 64. 69.

 91672 G 72. 77. 78. 71. 74. 64. 71.

 MEAN 70. 72. 73. 71. 71. 63. 69.

 S.D. 6.9 5.1 3.4 3.6 4.5 3.5 3.2

 S.E. 2.0 1.5 1.0 1.0 1.3 1.0 0.9

 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 610 of 1107
 TABLE A22 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING GESTATION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 0- 4 4- 7 7-11 11-14 14-17 17-20 0-20

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91632 G 63. 64. 64. 67. 65. 59. 64.

 91640 G 63. 63. 63. 68. 72. 66. 66.

 91642 G 71. 73. 76. 69. 69. 69. 69.

 91647 G 65. 72. 65. 74. 67. 69. 68.

 91651 G 66. 68. 62. 66. 64. 61. 63.

 91659 G 61. 70. 71. 65. 74. 71. 68.

 91661 G 73. 79. 69. 72. 72. 59. 68.

 91663 G 75. 70. 75. 69. 70. 70. 69.

 91669 G 77. 78. 74. 67. 69. 66. 70.

 91673 G 62. 68. 68. 71. 75. 68. 67.

 91683 G 71. 73. 72. 71. 71. 65. 70.

 91685 G 79. 77. 79. 75. 74. 65. 73.

 MEAN 69. 71. 70. 70. 70. 66. 68.

 S.D. 6.3 5.1 5.6 3.1 3.5 4.1 2.7

 S.E. 1.8 1.5 1.6 0.9 1.0 1.2 0.8

 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 611 of 1107
 TABLE A22 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING GESTATION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 0- 4 4- 7 7-11 11-14 14-17 17-20 0-20

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91620 G 72. 68. 70. 64. 65. 62. 64.

 91628 G 65. 65. 66. 65. 69. 64. 65.

 91631 G 72. 80. 72. 74. 79. 66. 71.

 91636 G 80. 73. 73. 66. 68. 64. 70.

 91649 G 75. 86. 74. 76. 73. 69. 72.

 91650 G 63. 72. 73. 75. 67. 67. 67.

 91656 G 56. 62. 60. 63. 61. 54. 59.

 91671 G 70. 77. 69. 69. 70. 68. 68.

 91675 G 63. 74. 68. 68. 77. 70. 68.

 91677 G 67. 76. 73. 62. 70. 67. 68.

 91679 G 62. 73. 73. 72. 68. 70. 67.

 91684 G 48. 68. 67. 63. 68. 63. 60.

 MEAN 66. 73. 70. 68. 70. 65. 67.

 S.D. 8.7 6.6 4.1 5.1 4.9 4.5 4.0

 S.E. 2.5 1.9 1.2 1.5 1.4 1.3 1.2

 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 612 of 1107
 TABLE A22 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING GESTATION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 0- 4 4- 7 7-11 11-14 14-17 17-20 0-20

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 4: 175 PPM

---------------------------------------

 91622 G 60. 70. 64. 67. 69. 64. 64.

 91626 G 60. 66. 66. 69. 67. 67. 66.

 91643 G 54. 68. 67. 66. 75. 72. 66.

 91654 G 69. 72. 73. 66. 68. 73. 69.

 91657 G 52. 64. 61. 62. 68. 64. 61.

 91662 G 56. 69. 67. 62. 64. 63. 61.

 91666 G 62. 63. 67. 70. 69. 65. 64.

 91676 G 68. 78. 73. 73. 74. 74. 73.

 91678 G 63. 76. 76. 73. 65. 64. 69.

 91681 G 54. 58. 62. 62. 64. 64. 58.

 91682 G 64. 67. 64. 64. 63. 70. 64.

 MEAN 60. 68. 67. 67. 68. 67. 65.

 S.D. 5.7 5.7 4.8 4.1 3.9 4.2 4.3

 S.E. 1.7 1.7 1.5 1.2 1.2 1.3 1.3

 N 11 11 11 11 11 11 11

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 613 of 1107
 TABLE A22 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING GESTATION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 0- 4 4- 7 7-11 11-14 14-17 17-20 0-20

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91624 G 68. 73. 70. 68. 75. 64. 67.

 91625 G 64. 69. 66. 65. 67. 61. 65.

 91627 G 55. 60. 64. 68. 73. 65. 64.

 91634 G 72. 75. 68. 67. 71. 70. 71.

 91635 G 56. 63. 63. 65. 66. 59. 59.

 91638 G 75. 74. 78. 68. 70. 63. 71.

 91652 G 81. 80. 78. 78. 79. 72. 78.

 91655 G 69. 75. 68. 71. 78. 72. 71.

 91658 G 56. 67. 67. 61. 61. 58. 61.

 91667 G 64. 68. 65. 62. 65. 54. 61.

 91668 G 73. 79. 71. 72. 72. 62. 70.

 91680 G 61. 59. 63. 69. 70. 65. 62.

 MEAN 66. 70. 68. 68. 71. 64. 67.

 S.D. 8.3 7.0 5.1 4.6 5.3 5.6 5.6

 S.E. 2.4 2.0 1.5 1.3 1.5 1.6 1.6

 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

 PGFWv4.11

 01/07/2014

Page 614 of 1107
 TABLE A23 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING LACTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91629 29.

 91630 29.

 91633 29.

 91637 30.

 91639 30.

 91644 23.

 91645 35.

 91648 29.

 91653 50.

 91660 34.

 91670 31.

 91672 37.

 MEAN 32.

 S.D. 6.7

 S.E. 1.9

 N 12

Page 615 of 1107
 TABLE A23 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING LACTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91632 29.

 91640 32.

 91642 33.

 91647 21.

 91651 39.

 91659 30.

 91661 32.

 91663 33.

 91669 32.

 91673 25.

 91683 28.

 91685 22.

 MEAN 30.

 S.D. 5.1

 S.E. 1.5

 N 12

Page 616 of 1107
 TABLE A23 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING LACTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91620 46.

 91628 27.

 91631 35.

 91636 24.

 91649 37.

 91650 32.

 91656 29.

 91671 28.

 91675 34.

 91677 16.

 91679 26.

 91684 19.

 MEAN 29.

 S.D. 8.1

 S.E. 2.3

 N 12

Page 617 of 1107
 TABLE A23 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING LACTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 4: 175 PPM

---------------------------------------

 91622 24.

 91626 38.

 91643 29.

 91654 NA

 91657 22.

 91662 22.

 91666 26.

 91676 29.

 91678 38.

 91681 28.

 91682 19.

 MEAN 28.

 S.D. 6.4

 S.E. 2.0

 N 10

NA = NOT APPLICABLE

Page 618 of 1107
 TABLE A23 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING LACTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91624 30.

 91625 40.

 91627 30.

 91634 38.

 91635 36.

 91638 35.

 91652 43.

 91655 30.

 91658 40.

 91667 38.

 91668 29.

 91680 37.

 MEAN 36.

 S.D. 4.7

 S.E. 1.4

 N 12

 PLFWv4.13

 01/07/2014

Page 619 of 1107
 TABLE A24 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING LACTATION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91629 99.

 91630 92.

 91633 82.

 91637 97.

 91639 85.

 91644 75.

 91645 104.

 91648 81.

 91653 150.

 91660 98.

 91670 93.

 91672 99.

 MEAN 96.

 S.D. 19.1

 S.E. 5.5

 N 12

Page 620 of 1107
 TABLE A24 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING LACTATION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91632 93.

 91640 91.

 91642 96.

 91647 72.

 91651 120.

 91659 82.

 91661 103.

 91663 101.

 91669 105.

 91673 78.

 91683 88.

 91685 76.

 MEAN 92.

 S.D. 14.0

 S.E. 4.0

 N 12

Page 621 of 1107
 TABLE A24 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING LACTATION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91620 133.

 91628 96.

 91631 100.

 91636 82.

 91649 123.

 91650 92.

 91656 88.

 91671 83.

 91675 97.

 91677 52.

 91679 78.

 91684 66.

 MEAN 91.

 S.D. 22.2

 S.E. 6.4

 N 12

Page 622 of 1107
 TABLE A24 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING LACTATION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 4: 175 PPM

---------------------------------------

 91622 82.

 91626 108.

 91643 82.

 91654 NA

 91657 62.

 91662 66.

 91666 92.

 91676 92.

 91678 98.

 91681 88.

 91682 57.

 MEAN 83.

 S.D. 16.5

 S.E. 5.2

 N 10

NA = NOT APPLICABLE

Page 623 of 1107
 TABLE A24 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL FOOD CONSUMPTION DURING LACTATION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91624 93.

 91625 140.

 91627 100.

 91634 119.

 91635 111.

 91638 113.

 91652 123.

 91655 97.

 91658 130.

 91667 113.

 91668 88.

 91680 121.

 MEAN 112.

 S.D. 15.6

 S.E. 4.5

 N 12

 PLFWv4.13

 01/07/2014

Page 624 of 1107
 TABLE A25 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 0- 1 1- 2 2- 3 3- 4 4- 5 5- 6 6- 7 7- 8 8- 9 9- 10 10- 11 11- 12

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 1: 0 PPM

-------------------------------------------

 91555 50. 52. 77. 39. 36. 53. NA 37. 36. 38. 81. 29.

 91560 41. 43. 60. 47. 44. 54. 99. 41. 44. 50. 38. 36.

 91562 39. 44. 49. 40. 43. 47. 60. 54. 42. 34. 47. 46.

 91563 33. 37. 44. 37. 33. 33. 37. 37. 33. 34. 46. 28.

 91564 36. 36. 34. 32. 30. 29. 33. 32. 36. 34. 32. 35.

 91567 32. 33. 32. 39. 31. 27. 33. 28. 27. 28. 31. 31.

 91579 41. 52. 71. 51. 49. 69. NA 44. 48. 45. 41. 47.

 91586 46. 45. 58. 39. 37. 45. 53. 48. 39. 35. 44. 34.

 91591 42. 43. 51. 38. 35. 41. 43. 32. 33. 31. 39. 32.

 91592 34. 35. 36. 39. 33. 33. 36. 32. 42. 31. 38. 37.

 91609 35. 40. 35. 41. 33. 40. 37. 39. 38. 39. 38. 38.

 91615 37. 35. 36. 32. 32. 36. 33. 37. 30. 29. 37. 21.

 MEAN 39. 41. 49. 40. 36. 42. 46. 38. 37. 36. 43. 35.

 S.D. 5.5 6.4 15.2 5.4 6.0 12.0 20.7 7.4 6.1 6.7 12.9 7.1

 S.E. 1.6 1.8 4.4 1.6 1.7 3.5 6.5 2.1 1.8 1.9 3.7 2.1

 N 12 12 12 12 12 12 10 12 12 12 12 12

NA = NOT APPLICABLE

Page 625 of 1107
 TABLE A25 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 12- 13 0- 7 0- 13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 1: 0 PPM

-------------------------------------------

 91555 32. 51. 47.

 91560 34. 56. 49.

 91562 36. 46. 45.

 91563 31. 36. 36.

 91564 34. 33. 33.

 91567 31. 32. 31.

 91579 37. 55. 50.

 91586 34. 46. 43.

 91591 32. 42. 38.

 91592 36. 35. 36.

 91609 37. 37. 38.

 91615 37. 34. 33.

 MEAN 34. 42. 40.

 S.D. 2.4 8.6 6.4

 S.E. 0.7 2.5 1.9

 N 12 12 12

Page 626 of 1107
 TABLE A25 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 0- 1 1- 2 2- 3 3- 4 4- 5 5- 6 6- 7 7- 8 8- 9 9- 10 10- 11 11- 12

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 2: 50 PPM

-------------------------------------------

 91556 44. 52. 73. 44. 49. 58. 80. 39. 56. 36. 34. 39.

 91559 29. 35. 39. 30. 33. 26. 41. 28. 41. 29. 26. 25.

 91561 27. 40. 34. 45. 35. 44. 55. 37. 39. 38. 38. 35.

 91566 32. 37. 36. 36. 36. 33. 37. 33. 34. 31. 32. 34.

 91576 29. 34. 34. 30. 30. 28. 33. 31. 36. 29. 31. 27.

 91582 50. 44. 43. 42. 41. 38. 40. 37. 45. 35. 33. 40.

 91585 35. 52. 74. 44. 41. 49. 81. 51. 35. 36. 39. 43.

 91589 33. 37. 37. 36. 31. 32. 46. 49. 38. 32. 40. 53.

 91593 41. 40. 41. 37. 37. 35. 46. 43. 37. 34. 40. 52.

 91594 34. 40. 37. 37. 33. 32. 32. 34. 36. 31. 35. 36.

 91595 38. 38. 38. 38. 38. 40. 40. 39. 41. 37. 38. 42.

 91602 34. 41. 39. 38. 38. 36. 40. 40. 43. 35. 39. 46.

 MEAN 35. 41. 44. 38. 37. 38. 47. 38. 40. 34. 35. 39.

 S.D. 6.7 5.8 14.0 5.0 5.1 9.3 16.4 6.9 5.8 3.1 4.3 8.6

 S.E. 1.9 1.7 4.0 1.4 1.5 2.7 4.7 2.0 1.7 0.9 1.2 2.5

 N 12 12 12 12 12 12 12 12 12 12 12 12

Page 627 of 1107
 TABLE A25 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 12- 13 0- 7 0- 13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 2: 50 PPM

-------------------------------------------

 91556 47. 57. 50.

 91559 28. 33. 32.

 91561 39. 40. 39.

 91566 33. 35. 34.

 91576 37. 31. 32.

 91582 43. 43. 41.

 91585 48. 54. 48.

 91589 38. 36. 39.

 91593 33. 40. 40.

 91594 37. 35. 35.

 91595 38. 38. 39.

 91602 39. 38. 39.

 MEAN 39. 40. 39.

 S.D. 5.7 7.9 5.8

 S.E. 1.6 2.3 1.7

 N 12 12 12

Page 628 of 1107
 TABLE A25 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 0- 1 1- 2 2- 3 3- 4 4- 5 5- 6 6- 7 7- 8 8- 9 9- 10 10- 11 11- 12

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 3: 100 PPM

-------------------------------------------

 91569 29. 34. 37. 26. 29. 30. 41. 45. 34. 31. 47. 46.

 91573 43. 42. 46. 42. 56. 55. 62. 56. 51. 41. 36. 30.

 91577 36. 44. 39. 37. 33. 30. 38. 29. 35. 28. 34. 32.

 91581 35. 39. 26. 32. 32. 37. 36. 36. 31. 33. 32. 34.

 91583 42. 47. 40. 35. 35. 35. 31. 31. 35. 35. 33. 33.

 91588 40. 37. 41. 35. 35. 30. 33. 32. 38. 36. 35. 26.

 91590 44. 49. 32. 48. 48. 46. 39. 44. 32. 34. 36. 56.

 91598 31. 38. 41. 35. 36. 37. 57. 40. 31. 29. 31. 29.

 91599 30. 35. 35. 37. 35. 36. 40. 35. 35. 26. 34. 32.

 91608 35. 33. 37. 36. 36. 33. 27. 33. 32. 37. 35. 38.

 91611 27. 36. 28. 36. 39. 33. 38. 29. 33. 27. 35. 32.

 91616 38. 58. 59. 44. 53. 42. 54. 55. 42. 40. 56. 39.

 MEAN 36. 41. 38. 37. 39. 37. 41. 39. 36. 33. 37. 36.

 S.D. 5.7 7.3 8.8 5.8 8.5 7.5 10.9 9.4 5.8 4.9 7.2 8.3

 S.E. 1.6 2.1 2.5 1.7 2.5 2.2 3.1 2.7 1.7 1.4 2.1 2.4

 N 12 12 12 12 12 12 12 12 12 12 12 12

Page 629 of 1107
 TABLE A25 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 12- 13 0- 7 0- 13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 3: 100 PPM

-------------------------------------------

 91569 29. 32. 35.

 91573 38. 50. 46.

 91577 32. 37. 34.

 91581 32. 34. 33.

 91583 31. 38. 36.

 91588 37. 36. 35.

 91590 35. 44. 42.

 91598 48. 39. 37.

 91599 44. 35. 35.

 91608 39. 34. 35.

 91611 36. 34. 33.

 91616 44. 50. 48.

 MEAN 37. 38. 37.

 S.D. 5.9 6.0 5.0

 S.E. 1.7 1.7 1.5

 N 12 12 12

Page 630 of 1107
 TABLE A25 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 0- 1 1- 2 2- 3 3- 4 4- 5 5- 6 6- 7 7- 8 8- 9 9- 10 10- 11 11- 12

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 4: 175 PPM

-------------------------------------------

 91565 32. 58. 79. 45. 44. 51. 70. 54. 37. 36. 39. 32.

 91568 33. 41. 44. 35. 41. 44. 57. 43. 37. 28. 34. 36.

 91570 38. 34. 42. 38. 37. 35. 42. 36. 38. 34. 36. 33.

 91572 37. 39. 33. 37. 34. 34. 34. 35. 42. 31. 28. 30.

 91580 33. 33. 34. 33. 33. 33. 36. 28. 36. 26. 36. 27.

 91584 41. 51. 49. 51. 47. 41. 43. 38. 47. 50. 53. 40.

 91587 49. 55. 64. 49. 54. 70. NA 52. 87. 40. 48. 43.

 91597 59. 69. 81. 62. 65. 72. 83. 57. 58. 50. 53. 55.

 91601 41. 45. 46. 46. 46. 47. 52. 45. 52. 54. 46. 43.

 91607 31. 39. 32. 36. 34. 33. 36. 34. 35. 37. 35. 37.

 91613 35. 36. 33. 32. 29. 32. 38. 32. 38. 34. 35. 36.

 91614 31. 50. 45. 48. 51. 38. 51. 40. 42. 39. 43. 43.

 MEAN 38. 46. 48. 43. 43. 44. 49. 41. 46. 38. 40. 38.

 S.D. 8.3 11.0 17.1 9.1 10.3 14.0 15.7 9.1 14.6 8.9 8.0 7.4

 S.E. 2.4 3.2 4.9 2.6 3.0 4.0 4.7 2.6 4.2 2.6 2.3 2.1

 N 12 12 12 12 12 12 11 12 12 12 12 12

NA = NOT APPLICABLE

Page 631 of 1107
 TABLE A25 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 12- 13 0- 7 0- 13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 4: 175 PPM

-------------------------------------------

 91565 53. 54. 48.

 91568 29. 42. 39.

 91570 51. 38. 38.

 91572 46. 35. 35.

 91580 37. 34. 33.

 91584 44. 46. 46.

 91587 49. 57. 55.

 91597 53. 70. 63.

 91601 53. 46. 47.

 91607 45. 34. 36.

 91613 39. 34. 35.

 91614 41. 45. 43.

 MEAN 45. 45. 43.

 S.D. 7.5 11.2 9.2

 S.E. 2.2 3.2 2.6

 N 12 12 12

Page 632 of 1107
 TABLE A25 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 0- 1 1- 2 2- 3 3- 4 4- 5 5- 6 6- 7 7- 8 8- 9 9- 10 10- 11 11- 12

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 5: 10000 PPM

-------------------------------------------

 91554 36. 34. 43. 34. 35. 49. 72. 36. NA 28. 32. 33.

 91557 40. 50. 60. 49. 42. 52. 53. 55. 51. 49. 45. 54.

 91558 33. 40. 46. 35. 35. 38. 47. 42. 38. 38. 42. 42.

 91571 31. 32. 28. 26. 29. 27. 27. 24. 27. 15. 27. 26.

 91575 32. 38. 37. 34. 37. 37. 38. 40. 41. 36. 38. 40.

 91600 40. 50. 46. 37. 39. 36. 38. 36. 40. 42. 36. 38.

 91603 38. 52. 66. 40. 43. 52. 80. 59. 33. 27. 28. 56.

 91604 36. 39. 46. 34. 39. 44. 64. 43. 52. 35. 47. 52.

 91605 31. 31. 39. 33. 27. 32. 39. 34. 32. 26. 33. 37.

 91612 33. 30. 33. 32. 29. 27. 31. 26. 30. 33. 31. 32.

 91618 29. 37. 32. 30. 34. 27. 31. 30. 36. 23. 35. 34.

 91619 32. 35. 37. 35. 38. 32. 33. 35. 34. 28. 32. 34.

 MEAN 34. 39. 43. 35. 36. 38. 46. 38. 38. 32. 35. 40.

 S.D. 3.7 7.7 11.3 5.7 5.1 9.5 17.4 10.6 8.2 9.1 6.3 9.5

 S.E. 1.1 2.2 3.2 1.7 1.5 2.7 5.0 3.1 2.5 2.6 1.8 2.7

 N 12 12 12 12 12 12 12 12 11 12 12 12

NA = NOT APPLICABLE

Page 633 of 1107
 TABLE A25 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 12- 13 0- 7 0- 13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 5: 10000 PPM

-------------------------------------------

 91554 63. 43. 41.

 91557 41. 50. 49.

 91558 51. 39. 40.

 91571 32. 29. 27.

 91575 38. 36. 37.

 91600 43. 41. 40.

 91603 65. 53. 49.

 91604 39. 43. 44.

 91605 38. 33. 33.

 91612 39. 31. 31.

 91618 33. 31. 32.

 91619 34. 35. 34.

 MEAN 43. 39. 38.

 S.D. 11.0 7.6 7.1

 S.E. 3.2 2.2 2.1

 N 12 12 12

 PJTFWv4.26

 01/20/2014

Page 634 of 1107
 TABLE A26 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 0- 7 7- 13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 1: 0 PPM

-------------------------------------------

 91555 131. 102.

 91560 148. 103.

 91562 122. 111.

 91563 100. 92.

 91564 88. 88.

 91567 91. 80.

 91579 142. 107.

 91586 125. 101.

 91591 108. 82.

 91592 86. 82.

 91609 101. 99.

 91615 90. 78.

 MEAN 111. 94.

 S.D. 21.9 11.6

 S.E. 6.3 3.4

 N 12 12

Page 635 of 1107
 TABLE A26 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 0- 7 7- 13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 2: 50 PPM

-------------------------------------------

 91556 150. 103.

 91559 88. 77.

 91561 110. 95.

 91566 96. 86.

 91576 87. 84.

 91582 101. 88.

 91585 134. 99.

 91589 103. 113.

 91593 102. 97.

 91594 92. 87.

 91595 95. 92.

 91602 94. 94.

 MEAN 104. 93.

 S.D. 19.1 9.6

 S.E. 5.5 2.8

 N 12 12

Page 636 of 1107
 TABLE A26 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 0- 7 7- 13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 3: 100 PPM

-------------------------------------------

 91569 87. 102.

 91573 134. 111.

 91577 102. 84.

 91581 84. 83.

 91583 99. 86.

 91588 90. 82.

 91590 112. 97.

 91598 107. 90.

 91599 99. 91.

 91608 90. 89.

 91611 86. 77.

 91616 129. 114.

 MEAN 101. 92.

 S.D. 16.4 11.5

 S.E. 4.7 3.3

 N 12 12

Page 637 of 1107
 TABLE A26 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 0- 7 7- 13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 4: 175 PPM

-------------------------------------------

 91565 155. 116.

 91568 101. 80.

 91570 100. 95.

 91572 94. 92.

 91580 94. 84.

 91584 124. 116.

 91587 151. 129.

 91597 187. 139.

 91601 128. 129.

 91607 90. 94.

 91613 88. 91.

 91614 114. 98.

 MEAN 119. 105.

 S.D. 31.3 19.6

 S.E. 9.0 5.7

 N 12 12

Page 638 of 1107
 TABLE A26 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 MALES

 DAY 0- 7 7- 13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 5: 10000 PPM

-------------------------------------------

 91554 120. 103.

 91557 127. 122.

 91558 102. 107.

 91571 83. 71.

 91575 93. 95.

 91600 101. 94.

 91603 141. 117.

 91604 111. 114.

 91605 95. 93.

 91612 87. 90.

 91618 85. 86.

 91619 96. 88.

 MEAN 103. 98.

 S.D. 18.0 14.7

 S.E. 5.2 4.3

 N 12 12

 PJTFWv4.26

 01/20/2014

Page 639 of 1107
 TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 0- 1 1- 2 2- 3 3- 4 4- 5 5- 6 6- 7 7- 8 8- 9 9- 10 10- 11 11- 12

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 1: 0 PPM

-------------------------------------------

 91629 28. 32. 36. 49. 23. 28. 35. 35. 40. 23. 26. 25.

 91630 12. 34. 32. 31. 28. 34. 0. 30. 45. 32. 30. 36.

 91633 37. NA 33. 31. 34. 28. 31. 32. 34. 28. 35. 39.

 91637 36. 33. 38. 57. 37. 33. 38. 36. 37. 33. 38. 41.

 91639 29. 29. 26. 28. 24. 31. 27. 33. 38. 32. 54. 23.

 91644 26. 50. 27. 41. 26. 27. 60. 26. 67. 19. 76. 58.

 91645 50. 34. 40. 85. 29. 42. 54. 55. 35. 42. 34. 55.

 91648 24. 26. 36. 32. 29. 16. 40. 34. 34. 16. 32. 27.

 91653 28. 23. 34. 46. 25. 24. 28. 32. 39. 29. 26. 43.

 91660 33. 32. 35. 33. 31. 31. 32. 31. 32. 27. 23. 25.

 91670 22. 42. 32. 34. 29. 37. 37. 35. 39. 16. 39. 37.

 91672 19. 37. 31. 37. 29. 49. 37. 42. 25. 31. 35. 36.

 MEAN 29. 34. 33. 42. 29. 32. 35. 35. 39. 27. 37. 37.

 S.D. 9.8 7.3 4.2 16.2 4.2 8.6 14.8 7.2 10.1 7.7 14.6 11.3

 S.E. 2.8 2.2 1.2 4.7 1.2 2.5 4.3 2.1 2.9 2.2 4.2 3.3

 N 12 11 12 12 12 12 12 12 12 12 12 12

NA = NOT APPLICABLE

Page 640 of 1107
 TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 12- 13 13- 27 27- 28 28- 29 29- 30 30- 31 31- 32 32- 33 33- 34 34- 35 35- 36 36- 37

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 1: 0 PPM

-------------------------------------------

 91629 23. NA NA NA NA NA NA NA NA NA NA NA

 91630 25. NA NA NA NA NA NA NA NA NA NA NA

 91633 41. NA NA NA NA NA NA NA NA NA NA NA

 91637 41. NA NA NA NA NA NA NA NA NA NA NA

 91639 37. NA NA NA NA NA NA NA NA NA NA NA

 91644 58. NA NA NA NA NA NA NA NA NA NA NA

 91645 44. NA NA NA NA NA NA NA NA NA NA NA

 91648 29. NA NA NA NA NA NA NA NA NA NA NA

 91653 40. NA NA NA NA NA NA NA NA NA NA NA

 91660 31. NA NA NA NA NA NA NA NA NA NA NA

 91670 34. NA NA NA NA NA NA NA NA NA NA NA

 91672 38. NA NA NA NA NA NA NA NA NA NA NA

 MEAN 37. NA NA NA NA NA NA NA NA NA NA NA

 S.D. 9.5

 S.E. 2.7

 N 12

NA = NOT APPLICABLE

Page 641 of 1107
 TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 37- 38 38- 39 39- 40 40- 41 41- 42 42- 43 43- 44 44- 45 45- 46 46- 47 47- 48 48- 49

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 1: 0 PPM

-------------------------------------------

 91629 NA NA NA NA NA

 91630 NA NA NA NA NA NA

 91633 NA NA NA

 91637 NA NA

 91639 NA NA NA NA NA

 91644 NA NA NA

 91645 NA NA NA NA NA NA

 91648 NA NA NA

 91653 NA NA NA NA NA

 91660 NA NA NA NA NA

 91670 NA NA NA NA NA NA

 91672 NA NA NA NA NA NA

 MEAN NA NA NA NA NA NA

 S.D.

 S.E.

 N

NA = NOT APPLICABLE

Page 642 of 1107
 TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 49- 50 50- 51 51- 52 0- 7 0- 13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 1: 0 PPM

-------------------------------------------

 91629 33. 31.

 91630 24. 28.

 91633 33. 34.

 91637 39. 38.

 91639 28. 32.

 91644 37. 43.

 91645 48. 46.

 91648 29. 29.

 91653 30. 32.

 91660 33. 31.

 91670 33. 33.

 91672 34. 34.

 MEAN 33. 34.

 S.D. 6.1 5.6

 S.E. 1.7 1.6

 N 12 12

Page 643 of 1107
 TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 0- 1 1- 2 2- 3 3- 4 4- 5 5- 6 6- 7 7- 8 8- 9 9- 10 10- 11 11- 12

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 2: 50 PPM

-------------------------------------------

 91632 28. 33. 31. 57. 24. 32. 39. 37. 50. 30. 31. 44.

 91640 31. 26. 31. 69. 43. 38. 45. 36. 31. 30. 27. 29.

 91642 17. 24. 33. 42. 19. 23. 34. 29. 28. 17. 32. 28.

 91647 22. 44. 39. 51. 25. 41. 46. 41. 43. 45. 55. 61.

 91651 25. 23. 26. 26. 24. 27. 27. 26. 20. 19. 28. 23.

 91659 13. 32. 28. 36. 26. 22. 34. 31. 37. 21. 34. 33.

 91661 38. 44. 64. 57. 41. 45. NA 57. 44. 35. 40. 50.

 91663 38. 38. 28. 74. 37. 35. 49. 29. 39. 39. 52. 64.

 91669 15. 28. 28. 42. 24. 19. 36. 29. 35. 35. 31. 25.

 91673 19. 32. 32. 36. 25. 34. 37. 31. 30. 31. 30. 33.

 91683 26. 25. 27. 34. 31. 33. 36. 24. 33. 33. 29. 34.

 91685 20. 27. 27. 29. 23. 27. 35. 25. 29. 29. 24. 28.

 MEAN 24. 31. 33. 46. 29. 31. 38. 33. 35. 30. 34. 38.

 S.D. 8.1 7.2 10.4 15.4 7.9 7.9 6.3 9.1 8.3 8.1 9.8 13.7

 S.E. 2.3 2.1 3.0 4.4 2.3 2.3 1.9 2.6 2.4 2.3 2.8 4.0

 N 12 12 12 12 12 12 11 12 12 12 12 12

NA = NOT APPLICABLE

Page 644 of 1107
 TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 12- 13 13- 27 27- 28 28- 29 29- 30 30- 31 31- 32 32- 33 33- 34 34- 35 35- 36 36- 37

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 2: 50 PPM

-------------------------------------------

 91632 52. NA NA NA NA NA NA NA NA NA NA NA

 91640 27. NA NA NA NA NA NA NA NA NA NA NA

 91642 27. NA NA NA NA NA NA NA NA NA NA NA

 91647 35. NA NA NA NA NA NA NA NA NA NA NA

 91651 24. NA NA NA NA NA NA NA NA NA NA NA

 91659 31. NA NA NA NA NA NA NA NA NA NA NA

 91661 70. NA NA NA NA NA NA NA NA NA NA NA

 91663 62. NA NA NA NA NA NA NA NA NA NA NA

 91669 32. NA NA NA NA NA NA NA NA NA NA NA

 91673 26. NA NA NA NA NA NA NA NA NA NA NA

 91683 31. NA NA NA NA NA NA NA NA NA NA NA

 91685 30. NA NA NA NA NA NA NA NA NA NA NA

 MEAN 37. NA NA NA NA NA NA NA NA NA NA NA

 S.D. 15.2

 S.E. 4.4

 N 12

NA = NOT APPLICABLE

Page 645 of 1107
 TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 37- 38 38- 39 39- 40 40- 41 41- 42 42- 43 43- 44 44- 45 45- 46 46- 47 47- 48 48- 49

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 2: 50 PPM

-------------------------------------------

 91632 NA NA NA NA NA NA NA

 91640 NA NA NA NA NA NA NA

 91642 NA NA NA NA

 91647 NA NA NA NA NA NA

 91651 NA NA NA NA NA

 91659 NA NA NA NA

 91661 NA NA NA

 91663 NA NA NA NA NA

 91669 NA NA NA

 91673 NA NA NA NA NA NA

 91683 NA NA NA NA NA NA NA

 91685 NA NA NA

 MEAN NA NA NA NA NA NA NA

 S.D.

 S.E.

 N

NA = NOT APPLICABLE

Page 646 of 1107
 TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 49- 50 50- 51 51- 52 0- 7 0- 13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 2: 50 PPM

-------------------------------------------

 91632 35. 38.

 91640 40. 36.

 91642 28. 27.

 91647 38. 42.

 91651 25. 24.

 91659 27. 29.

 91661 48. 49.

 91663 43. 45.

 91669 28. 29.

 91673 31. 30.

 91683 30. 30.

 91685 27. 27.

 MEAN 33. 34.

 S.D. 7.4 7.8

 S.E. 2.1 2.2

 N 12 12

Page 647 of 1107
 TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 0- 1 1- 2 2- 3 3- 4 4- 5 5- 6 6- 7 7- 8 8- 9 9- 10 10- 11 11- 12

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 3: 100 PPM

-------------------------------------------

 91620 15. 36. 33. 65. 29. 24. 40. 64. 35. 29. 26. 41.

 91628 33. 26. 42. 73. 40. 22. 44. 65. 32. 35. 33. 49.

 91631 25. 39. 48. 79. 28. 30. 46. 52. 31. 25. 25. 49.

 91636 36. 37. 36. 64. 46. 47. 41. 57. 47. 48. 42. 58.

 91649 19. 27. 15. 31. 27. 28. 32. 22. 30. 27. 29. 32.

 91650 26. 37. 30. 34. 36. 38. 48. 27. 30. 35. 41. 34.

 91656 15. 35. 38. 64. 33. 28. 42. 40. 67. 34. 32. 48.

 91671 37. 38. 46. 60. 26. 27. 42. 39. 65. 41. 39. 30.

 91675 25. 29. 25. 41. 20. 31. 30. 26. 33. 49. 28. 29.

 91677 28. 29. 33. 26. 19. 31. 34. 27. 35. 44. 33. 35.

 91679 34. 32. 34. 36. 38. 41. 40. 31. 35. 41. 42. 41.

 91684 33. 18. 37. 31. 29. 34. 42. 35. 35. 32. 25. 38.

 MEAN 27. 32. 35. 50. 31. 32. 40. 40. 40. 37. 33. 40.

 S.D. 7.6 6.2 9.0 18.8 7.9 7.2 5.5 15.3 13.2 8.0 6.5 9.0

 S.E. 2.2 1.8 2.6 5.4 2.3 2.1 1.6 4.4 3.8 2.3 1.9 2.6

 N 12 12 12 12 12 12 12 12 12 12 12 12

Page 648 of 1107
 TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 12- 13 13- 27 27- 28 28- 29 29- 30 30- 31 31- 32 32- 33 33- 34 34- 35 35- 36 36- 37

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 3: 100 PPM

-------------------------------------------

 91620 43. NA NA NA NA NA NA NA NA NA NA NA

 91628 52. NA NA NA NA NA NA NA NA NA NA NA

 91631 67. NA NA NA NA NA NA NA NA NA NA NA

 91636 55. NA NA NA NA NA NA NA NA NA NA NA

 91649 33. NA NA NA NA NA NA NA NA NA NA NA

 91650 34. NA NA NA NA NA NA NA NA NA NA NA

 91656 85. NA NA NA NA NA NA NA NA NA NA NA

 91671 53. NA NA NA NA NA NA NA NA NA NA NA

 91675 31. NA NA NA NA NA NA NA NA NA NA NA

 91677 33. NA NA NA NA NA NA NA NA NA NA NA

 91679 39. NA NA NA NA NA NA NA NA NA NA NA

 91684 43. NA NA NA NA NA NA NA NA NA NA NA

 MEAN 47. NA NA NA NA NA NA NA NA NA NA NA

 S.D. 16.3

 S.E. 4.7

 N 12

NA = NOT APPLICABLE

Page 649 of 1107
 TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 11

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 37- 38 38- 39 39- 40 40- 41 41- 42 42- 43 43- 44 44- 45 45- 46 46- 47 47- 48 48- 49

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 3: 100 PPM

-------------------------------------------

 91620 NA NA NA NA NA NA

 91628 NA NA NA NA

 91631 NA NA NA NA

 91636 NA NA NA NA NA

 91649 NA NA NA

 91650 NA NA NA

 91656 NA NA NA NA NA NA NA NA

 91671 NA NA NA NA NA NA NA NA

 91675 NA NA NA NA

 91677 NA NA NA NA NA

 91679 NA NA NA

 91684 NA NA NA NA

 MEAN NA NA NA NA NA NA NA NA

 S.D.

 S.E.

 N

NA = NOT APPLICABLE

Page 650 of 1107
 TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 12

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 49- 50 50- 51 51- 52 0- 7 0- 13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 3: 100 PPM

-------------------------------------------

 91620 35. 37.

 91628 40. 42.

 91631 42. 42.

 91636 44. 47.

 91649 26. 27.

 91650 35. 35.

 91656 37. 43.

 91671 39. 42.

 91675 29. 31.

 91677 28. 31.

 91679 36. 37.

 91684 32. 33.

 MEAN 35. 37.

 S.D. 5.7 6.1

 S.E. 1.6 1.7

 N 12 12

Page 651 of 1107
 TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 13

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 0- 1 1- 2 2- 3 3- 4 4- 5 5- 6 6- 7 7- 8 8- 9 9- 10 10- 11 11- 12

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 4: 175 PPM

-------------------------------------------

 91622 29. 46. 63. 83. 40. 42. 55. 47. 26. 34. 37. 37.

 91623 21. 32. 39. 61. 31. 32. 41. 34. 45. 48. 40. 37.

 91626 28. 33. 46. 54. 45. 37. 33. 42. 54. 43. 36. 32.

 91643 28. 33. 29. 40. 38. 37. 34. 27. 34. 30. 35. 32.

 91654 29. 38. 36. 41. 34. 42. 41. 42. 45. 40. 45. 39.

 91657 25. 47. 49. 57. 41. 43. 45. 37. 44. 45. 44. 50.

 91662 17. 31. 32. 53. 28. 39. 37. 30. 34. 33. 34. 32.

 91666 31. 30. 22. 40. NA 35. 31. 24. 33. 31. 31. 36.

 91676 22. 25. 26. 27. 18. 29. 29. 25. 38. 25. 25. 28.

 91678 32. 32. 42. 35. 34. 10. 20. 25. 50. 49. 36. 37.

 91681 50. 31. 45. 41. 34. 38. 31. 24. 36. 37. 36. 38.

 91682 22. 48. 52. 54. 39. 40. 46. 45. 49. 42. 39. 46.

 MEAN 28. 35. 40. 49. 35. 35. 37. 33. 41. 38. 37. 37.

 S.D. 8.3 7.4 12.1 14.8 7.2 8.7 9.2 8.6 8.4 7.6 5.4 6.2

 S.E. 2.4 2.1 3.5 4.3 2.2 2.5 2.7 2.5 2.4 2.2 1.6 1.8

 N 12 12 12 12 11 12 12 12 12 12 12 12

NA = NOT APPLICABLE

Page 652 of 1107
 TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 14

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 12- 13 13- 27 27- 28 28- 29 29- 30 30- 31 31- 32 32- 33 33- 34 34- 35 35- 36 36- 37

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 4: 175 PPM

-------------------------------------------

 91622 34. NA NA NA NA NA NA NA NA NA NA NA

 91623 39. NA 46. 37. 48. 32. 33. 38. 32. 34. 30. 32.

 91626 41. NA NA NA NA NA NA NA NA NA NA NA

 91643 36. NA NA NA NA NA NA NA NA NA NA NA

 91654 49. NA NA NA NA NA NA NA NA NA NA NA

 91657 47. NA NA NA NA NA NA NA NA NA NA NA

 91662 44. NA NA NA NA NA NA NA NA NA NA NA

 91666 35. NA NA NA NA NA NA NA NA NA NA NA

 91676 33. NA NA NA NA NA NA NA NA NA NA NA

 91678 38. NA NA NA NA NA NA NA NA NA NA NA

 91681 46. NA NA NA NA NA NA NA NA NA NA NA

 91682 53. NA NA NA NA NA NA NA NA NA NA NA

 MEAN 41. NA 46. 37. 48. 32. 33. 38. 32. 34. 30. 32.

 S.D. 6.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

 S.E. 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

 N 12 1 1 1 1 1 1 1 1 1 1

NA = NOT APPLICABLE

Page 653 of 1107
 TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 15

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 37- 38 38- 39 39- 40 40- 41 41- 42 42- 43 43- 44 44- 45 45- 46 46- 47 47- 48 48- 49

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 4: 175 PPM

-------------------------------------------

 91622 NA NA NA

 91623 34. 30. 39. 32. 37. 33. 31. 33. 33. 33. 29. 31.

 91626 NA NA NA NA NA NA

 91643 NA NA NA NA NA NA NA NA NA

 91654 NA NA NA NA NA NA NA

 91657 NA NA NA NA NA NA NA NA NA NA NA NA

 91662 NA NA NA NA NA NA

 91666 NA NA NA NA

 91676 NA NA NA NA NA

 91678 NA NA NA NA

 91681 NA NA NA NA NA NA NA NA NA NA NA NA

 91682 NA NA NA NA NA NA

 MEAN 34. 30. 39. 32. 37. 33. 31. 33. 33. 33. 29. 31.

 S.D. 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

 S.E. 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

 N 1 1 1 1 1 1 1 1 1 1 1 1

NA = NOT APPLICABLE

Page 654 of 1107
 TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 16

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 49- 50 50- 51 51- 52 0- 7 0- 13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 4: 175 PPM

-------------------------------------------

 91622 51. 44.

 91623 33. 33. 29. 37. 38.

 91626 39. 40.

 91643 34. 33.

 91654 37. 40.

 91657 NA NA 44. 44.

 91662 34. 34.

 91666 32. 32.

 91676 25. 27.

 91678 29. 34.

 91681 NA 39. 37.

 91682 43. 44.

 MEAN 33. 33. 29. 37. 37.

 S.D. 0.0 0.0 0.0 7.0 5.5

 S.E. 0.0 0.0 0.0 2.0 1.6

 N 1 1 1 12 12

NA = NOT APPLICABLE

Page 655 of 1107
 TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 17

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 0- 1 1- 2 2- 3 3- 4 4- 5 5- 6 6- 7 7- 8 8- 9 9- 10 10- 11 11- 12

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 5: 10000 PPM

-------------------------------------------

 91624 27. 26. 30. 30. 30. 32. 37. 39. 50. 31. 33. 33.

 91625 29. 29. 28. 39. 31. 31. 29. 32. 49. 33. 31. 27.

 91627 28. 35. 37. 42. 29. 38. 39. 29. 35. 38. 36. 36.

 91634 27. 33. 32. 36. 32. 33. 32. 27. 41. 30. 27. 29.

 91635 11. 27. 23. 27. 24. 25. 31. 25. 29. 27. 29. 26.

 91638 19. 29. 29. 33. 33. 28. 33. 26. 26. 25. 29. 32.

 91652 31. 39. 45. 61. 29. 37. 45. 44. 30. 30. 28. 38.

 91655 23. 30. 27. 38. 25. 28. 31. 33. 38. 27. 22. 27.

 91658 27. 35. 38. 45. 37. 38. 38. 40. 40. 33. 23. 33.

 91667 20. 31. 27. 24. 28. 29. 31. 26. 38. 27. 30. 30.

 91668 19. 27. 28. 27. 26. 24. 29. 32. 34. 23. 21. 34.

 91680 17. 31. 30. 30. 32. 26. 35. 27. 26. 24. 26. 26.

 MEAN 23. 31. 31. 36. 30. 31. 34. 32. 36. 29. 28. 31.

 S.D. 6.1 3.9 5.9 10.1 3.5 4.9 4.6 6.4 8.0 4.5 4.5 4.1

 S.E. 1.8 1.1 1.7 2.9 1.0 1.4 1.3 1.8 2.3 1.3 1.3 1.2

 N 12 12 12 12 12 12 12 12 12 12 12 12

Page 656 of 1107
 TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 18

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 12- 13 13- 27 27- 28 28- 29 29- 30 30- 31 31- 32 32- 33 33- 34 34- 35 35- 36 36- 37

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 5: 10000 PPM

-------------------------------------------

 91624 48. NA NA NA NA NA NA NA NA NA NA NA

 91625 53. NA NA NA NA NA NA NA NA NA NA NA

 91627 40. NA NA NA NA NA NA NA NA NA NA NA

 91634 48. NA NA NA NA NA NA NA NA NA NA NA

 91635 33. NA NA NA NA NA NA NA NA NA NA NA

 91638 32. NA NA NA NA NA NA NA NA NA NA NA

 91652 47. NA NA NA NA NA NA NA NA NA NA NA

 91655 37. NA NA NA NA NA NA NA NA NA NA NA

 91658 34. NA NA NA NA NA NA NA NA NA NA NA

 91667 43. NA NA NA NA NA NA NA NA NA NA NA

 91668 40. NA NA NA NA NA NA NA NA NA NA NA

 91680 32. NA NA NA NA NA NA NA NA NA NA NA

 MEAN 40. NA NA NA NA NA NA NA NA NA NA NA

 S.D. 7.2

 S.E. 2.1

 N 12

NA = NOT APPLICABLE

Page 657 of 1107
 TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 19

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 37- 38 38- 39 39- 40 40- 41 41- 42 42- 43 43- 44 44- 45 45- 46 46- 47 47- 48 48- 49

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 5: 10000 PPM

-------------------------------------------

 91624 NA NA NA NA NA

 91625 NA NA NA NA NA NA

 91627 NA NA NA

 91634 NA NA NA NA NA NA

 91635 NA NA NA

 91638 NA NA NA NA NA

 91652 NA NA NA

 91655 NA NA NA

 91658 NA NA NA NA

 91667 NA NA NA NA

 91668 NA NA NA NA

 91680 NA NA NA

 MEAN NA NA NA NA NA NA

 S.D.

 S.E.

 N

NA = NOT APPLICABLE

Page 658 of 1107
 TABLE A27 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 20

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 49- 50 50- 51 51- 52 0- 7 0- 13

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 5: 10000 PPM

-------------------------------------------

 91624 30. 34.

 91625 31. 34.

 91627 36. 36.

 91634 32. 33.

 91635 24. 26.

 91638 29. 29.

 91652 41. 39.

 91655 29. 30.

 91658 37. 35.

 91667 27. 30.

 91668 26. 28.

 91680 29. 28.

 MEAN 31. 32.

 S.D. 4.8 3.9

 S.E. 1.4 1.1

 N 12 12

 PJTFWv4.26

 01/16/2014

Page 659 of 1107
 TABLE A28 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 0- 7 7- 13 13- 27 27- 35 35- 42 42- 49

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 1: 0 PPM

-------------------------------------------

 91629 136. 119. NA NA NA

 91630 96. 126. NA NA NA

 91633 117. 120. NA NA

 91637 158. 145. NA NA

 91639 102. 128. NA NA NA

 91644 151. 198. NA NA

 91645 177. 157. NA NA NA

 91648 111. 105. NA NA

 91653 118. 131. NA NA NA

 91660 125. 99. NA NA NA

 91670 127. 123. NA NA NA

 91672 127. 120. NA NA NA

 MEAN 129. 131. NA NA NA

 S.D. 23.5 26.3

 S.E. 6.8 7.6

 N 12 12

NA = NOT APPLICABLE

Page 660 of 1107
 TABLE A28 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 0- 7 7- 13 13- 27 27- 35 35- 42 42- 49

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 2: 50 PPM

-------------------------------------------

 91632 135. 147. NA NA NA

 91640 148. 106. NA NA NA

 91642 105. 97. NA NA

 91647 162. 192. NA NA NA

 91651 96. 84. NA NA NA

 91659 102. 108. NA NA

 91661 194. 187. NA NA

 91663 183. 183. NA NA NA

 91669 108. 113. NA NA

 91673 116. 111. NA NA NA

 91683 124. 121. NA NA NA

 91685 111. 110. NA NA

 MEAN 132. 130. NA NA NA

 S.D. 32.9 37.8

 S.E. 9.5 10.9

 N 12 12

NA = NOT APPLICABLE

Page 661 of 1107
 TABLE A28 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 0- 7 7- 13 13- 27 27- 35 35- 42 42- 49

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 3: 100 PPM

-------------------------------------------

 91620 135. 141. NA NA NA

 91628 170. 182. NA NA

 91631 159. 146. NA NA

 91636 188. 206. NA NA NA

 91649 111. 118. NA NA

 91650 138. 123. NA NA

 91656 138. 178. NA NA NA

 91671 157. 163. NA NA NA

 91675 106. 116. NA NA

 91677 119. 130. NA NA NA

 91679 133. 132. NA NA

 91684 129. 131. NA NA

 MEAN 140. 147. NA NA NA

 S.D. 24.3 28.8

 S.E. 7.0 8.3

 N 12 12

NA = NOT APPLICABLE

Page 662 of 1107
 TABLE A28 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 0- 7 7- 13 13- 27 27- 35 35- 42 42- 49

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 4: 175 PPM

-------------------------------------------

 91622 207. 142. NA NA

 91623 142. 151. NA 119. 105. 100.

 91626 147. 146. NA NA NA

 91643 128. 115. NA NA NA

 91654 153. 168. NA NA NA

 91657 161. 156. NA NA NA NA

 91662 129. 123. NA NA NA

 91666 135. 127. NA NA

 91676 109. 116. NA NA NA

 91678 105. 128. NA NA

 91681 149. 131. NA NA NA NA

 91682 156. 157. NA NA NA

 MEAN 143. 138. NA 119. 105. 100.

 S.D. 26.6 17.4 0.0 0.0 0.0

 S.E. 7.7 5.0 0.0 0.0 0.0

 N 12 12 1 1 1

NA = NOT APPLICABLE

Page 663 of 1107
 TABLE A28 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 FEMALES

 DAY 0- 7 7- 13 13- 27 27- 35 35- 42 42- 49

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMALS FROM GROUP 5: 10000 PPM

-------------------------------------------

 91624 127. 150. NA NA NA

 91625 127. 150. NA NA NA

 91627 142. 141. NA NA

 91634 131. 132. NA NA NA

 91635 88. 101. NA NA

 91638 116. 107. NA NA NA

 91652 166. 140. NA NA

 91655 119. 119. NA NA

 91658 145. 125. NA NA

 91667 99. 114. NA NA

 91668 103. 116. NA NA

 91680 114. 101. NA NA

 MEAN 123. 125. NA NA NA

 S.D. 21.7 17.7

 S.E. 6.3 5.1

 N 12 12

NA = NOT APPLICABLE

 PJTFWv4.26

 01/16/2014

Page 664 of 1107
 TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 0- 1 1- 2 2- 3 3- 4 4- 5 5- 6 6- 7 7- 8 8- 9

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91629 G 29. 29. 34. 36. 31. 34. 34. 32. 35.

 91630 G 27. 40. 37. 36. 35. 38. 37. 34. 40.

 91633 G 19. 26. 31. 33. 27. 31. 30. 32. 33.

 91637 G 32. 33. 37. 33. 31. 40. 41. 35. 32.

 91639 G 23. 25. 33. 36. 44. 35. 42. 45. 43.

 91644 G 30. 37. 37. 37. 34. 36. 34. 39. 65.

 91645 G 26. 32. 34. 48. 34. 37. 39. 37. 50.

 91648 G 26. 29. 31. 28. 33. 33. 37. 35. 33.

 91653 G 29. 34. 35. 33. 29. 38. 34. 37. 25.

 91660 G 25. 30. 32. 29. 32. 30. 32. 32. 32.

 91670 G 28. 34. 38. 42. 36. 35. 43. 40. 40.

 91672 G 32. 32. 30. 40. 34. 37. 39. 43. 40.

 MEAN 27. 32. 34. 36. 33. 35. 37. 37. 39.

 S.D. 3.7 4.3 2.7 5.5 4.2 3.0 4.1 4.3 10.4

 S.E. 1.1 1.2 0.8 1.6 1.2 0.9 1.2 1.2 3.0

 N 12 12 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 665 of 1107
 TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 9-10 10-11 11-12 12-13 13-14 14-15 15-16 16-17 17-18

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91629 G NA 35. 35. 39. 38. 36. 41. 39. 42.

 91630 G NA 39. 40. 41. 42. 49. 55. 53. 61.

 91633 G 33. 42. 37. 41. 40. 39. 50. 45. 42.

 91637 G 38. 35. 39. 39. 40. 41. 42. 43. 41.

 91639 G 44. 47. 49. 45. 45. 77. 81. 56. 65.

 91644 G 76. 50. 78. NA 51. 67. 41. 59. 54.

 91645 G 40. 38. 40. 44. 43. 44. 43. 44. 49.

 91648 G 34. 36. 45. 41. 41. 46. 44. 48. 46.

 91653 G 45. 33. 43. 35. 40. 40. 42. 43. 47.

 91660 G 33. 33. 33. 33. 35. 38. 40. 39. 41.

 91670 G 41. 40. 40. 45. 45. 43. 52. 47. 50.

 91672 G 37. 47. 35. 47. 42. 47. 44. 48. 51.

 MEAN 42. 40. 43. 41. 42. 47. 48. 47. 49.

 S.D. 12.7 5.8 12.0 4.3 4.0 12.4 11.5 6.3 7.8

 S.E. 4.0 1.7 3.5 1.3 1.2 3.6 3.3 1.8 2.3

 N 10 12 12 11 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

NA = NOT APPLICABLE

Page 666 of 1107
 TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 18-19 19-20 20-21 21-22 22-23 23-24 24-25 0- 4 4- 7

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91629 G 38. 38. 37. NA NA NA NA 32. 33.

 91630 G 56. 54. 47. NA NA NA NA 35. 37.

 91633 G 43. 39. 42. NA NA NA NA 27. 29.

 91637 G 42. 37. 50. NA NA NA NA 34. 37.

 91639 G 50. 51. 48. 31. NA NA NA 29. 40.

 91644 G 55. 37. 46. NA NA NA NA 35. 35.

 91645 G 42. 42. 48. NA NA NA NA 35. 37.

 91648 G 44. 45. 46. 39. NA NA NA 29. 34.

 91653 G 50. 40. 48. NA NA NA NA 33. 34.

 91660 G 43. 34. 42. 27. NA NA NA 29. 31.

 91670 G 51. 45. 47. NA NA NA NA 36. 38.

 91672 G 45. 45. 51. NA NA NA NA 34. 37.

 MEAN 47. 42. 46. 32. NA NA NA 32. 35.

 S.D. 5.7 6.0 3.9 6.1 3.1 3.1

 S.E. 1.6 1.7 1.1 3.5 0.9 0.9

 N 12 12 12 3 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

NA = NOT APPLICABLE

Page 667 of 1107
 TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 7-11 11-14 14-17 17-20 0-20

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91629 G 34. 37. 39. 39. 36.

 91630 G 38. 41. 52. 57. 43.

 91633 G 35. 39. 45. 41. 36.

 91637 G 35. 39. 42. 40. 38.

 91639 G 45. 46. 71. 55. 47.

 91644 G 58. 65. 56. 49. 48.

 91645 G 41. 42. 44. 44. 40.

 91648 G 35. 42. 46. 45. 38.

 91653 G 35. 39. 42. 46. 38.

 91660 G 33. 34. 39. 39. 34.

 91670 G 40. 43. 47. 49. 42.

 91672 G 42. 41. 46. 47. 41.

 MEAN 39. 42. 47. 46. 40.

 S.D. 7.0 7.8 8.9 5.9 4.3

 S.E. 2.0 2.2 2.6 1.7 1.3

 N 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 668 of 1107
 TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 0- 1 1- 2 2- 3 3- 4 4- 5 5- 6 6- 7 7- 8 8- 9

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91632 G 23. 30. 31. 26. 26. 28. 28. 26. 30.

 91640 G 28. 29. 30. 30. 29. 37. 39. 33. 35.

 91642 G 25. 28. 30. 30. 31. 29. 27. 30. 26.

 91647 G 32. 37. 46. 44. 45. 49. 40. 43. 46.

 91651 G 27. 30. 32. 28. 30. 28. 31. 30. 24.

 91659 G 37. 30. 35. 37. 37. 38. 34. 44. 41.

 91661 G 41. 43. 42. 46. 42. 46. 46. 43. 45.

 91663 G 34. 40. 40. 37. 44. 39. 39. 40. 43.

 91669 G 32. 28. 37. 36. 42. 38. 42. 38. 31.

 91673 G 29. 30. 27. 31. 33. 29. 36. 31. 29.

 91683 G 34. 41. 40. 40. 36. 36. 34. 38. 40.

 91685 G 28. 35. 38. 40. 36. 38. 42. 39. 38.

 MEAN 31. 33. 36. 35. 36. 36. 37. 36. 36.

 S.D. 5.2 5.5 5.8 6.4 6.3 6.9 5.9 6.0 7.6

 S.E. 1.5 1.6 1.7 1.9 1.8 2.0 1.7 1.7 2.2

 N 12 12 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 669 of 1107
 TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 9-10 10-11 11-12 12-13 13-14 14-15 15-16 16-17 17-18

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91632 G 31. 29. 35. 30. 32. 34. 34. 38. 39.

 91640 G 35. 38. 44. 42. 47. 46. 47. 54. 51.

 91642 G 28. 34. 35. 34. 35. 34. 42. 38. 45.

 91647 G 48. 45. 49. 51. 48. 50. 50. 56. 58.

 91651 G 29. 34. 34. 37. 33. 36. 34. 39. 41.

 91659 G 38. 45. 41. 45. 47. 51. 53. 56. 60.

 91661 G 44. 42. 50. 53. 55. 53. 60. 61. 54.

 91663 G 46. 45. 45. 41. 43. 43. 44. 54. 46.

 91669 G 31. 36. 32. 35. 40. 41. 41. 41. 45.

 91673 G 34. 33. 38. 37. 39. 42. 47. 51. 54.

 91683 G 38. 42. 46. 48. 46. 51. 56. 66. 58.

 91685 G 38. 43. 43. 48. 46. 46. 49. 49. 42.

 MEAN 37. 39. 41. 42. 43. 44. 46. 50. 49.

 S.D. 6.6 5.5 6.1 7.3 6.9 6.7 8.0 9.4 7.3

 S.E. 1.9 1.6 1.8 2.1 2.0 1.9 2.3 2.7 2.1

 N 12 12 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 670 of 1107
 TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 18-19 19-20 20-21 21-22 22-23 23-24 24-25 0- 4 4- 7

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91632 G 40. 35. 35. NA NA NA NA 28. 27.

 91640 G 46. 51. 45. NA NA NA NA 29. 35.

 91642 G 41. 36. 43. 33. NA NA NA 28. 29.

 91647 G 53. 49. 45. 39. NA NA NA 40. 45.

 91651 G 38. 37. 38. 37. NA NA NA 29. 30.

 91659 G 52. 53. 55. 52. NA NA NA 35. 36.

 91661 G 56. 53. 56. NA NA NA NA 43. 45.

 91663 G 47. 44. 46. 35. NA NA NA 38. 41.

 91669 G 45. 36. 40. 19. NA NA NA 33. 41.

 91673 G 49. 48. 44. 34. NA NA NA 29. 33.

 91683 G 60. 55. 48. NA NA NA NA 39. 35.

 91685 G 40. 41. 37. 30. NA NA NA 35. 39.

 MEAN 47. 45. 44. 35. NA NA NA 34. 36.

 S.D. 7.0 7.6 6.5 9.2 5.3 6.0

 S.E. 2.0 2.2 1.9 3.3 1.5 1.7

 N 12 12 12 8 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

NA = NOT APPLICABLE

Page 671 of 1107
 TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 7-11 11-14 14-17 17-20 0-20

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91632 G 29. 32. 35. 38. 31.

 91640 G 35. 44. 49. 49. 40.

 91642 G 30. 35. 38. 41. 33.

 91647 G 46. 49. 52. 53. 47.

 91651 G 29. 35. 36. 39. 33.

 91659 G 42. 44. 53. 55. 44.

 91661 G 44. 53. 58. 54. 49.

 91663 G 44. 43. 47. 46. 43.

 91669 G 34. 36. 41. 42. 37.

 91673 G 32. 38. 47. 50. 37.

 91683 G 40. 47. 58. 58. 45.

 91685 G 40. 46. 48. 41. 41.

 MEAN 37. 42. 47. 47. 40.

 S.D. 6.3 6.5 7.9 6.9 5.9

 S.E. 1.8 1.9 2.3 2.0 1.7

 N 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 672 of 1107
 TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 0- 1 1- 2 2- 3 3- 4 4- 5 5- 6 6- 7 7- 8 8- 9

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91620 G 33. 28. 36. 33. 37. 38. 41. 37. 32.

 91628 G 33. 37. 36. 38. 39. 36. 37. 38. 36.

 91631 G 29. 35. 36. 41. 37. 49. 44. 42. 42.

 91636 G 45. 56. 62. 63. 69. 58. 54. 58. 52.

 91649 G 24. 29. 34. 30. 39. 34. 31. 33. 32.

 91650 G 28. 35. 41. 40. 44. 47. 50. 45. 57.

 91656 G 29. 39. 40. 34. 37. 39. 39. 39. 36.

 91671 G 31. 38. 42. 33. 39. 41. 41. 47. 40.

 91675 G 30. 31. 40. 34. 40. 40. 43. 35. 40.

 91677 G 30. 26. 35. 33. 43. 41. 41. 45. 30.

 91679 G 42. 48. 50. 53. 48. 49. 57. 56. 45.

 91684 G 22. 30. 42. 40. 41. 46. 39. 40. 41.

 MEAN 31. 36. 41. 39. 43. 43. 43. 43. 40.

 S.D. 6.6 8.7 7.9 9.6 8.9 6.8 7.3 7.8 8.1

 S.E. 1.9 2.5 2.3 2.8 2.6 2.0 2.1 2.3 2.3

 N 12 12 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 673 of 1107
 TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 9-10 10-11 11-12 12-13 13-14 14-15 15-16 16-17 17-18

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91620 G 39. 40. 44. 37. 44. 47. 47. 49. 51.

 91628 G 39. 39. 39. 42. 43. 46. 47. 47. 51.

 91631 G 46. 49. 52. 53. 53. 57. 53. 52. 53.

 91636 G 58. 54. 52. 58. 57. 57. 59. 63. 55.

 91649 G 32. 33. 41. 38. 38. 37. 44. 45. 48.

 91650 G 51. 50. 53. 54. 56. 58. 62. 65. 60.

 91656 G 42. 44. 45. 42. 45. 45. 47. 47. 45.

 91671 G 41. 42. 49. 52. 55. 56. 55. 61. 59.

 91675 G 38. 44. 42. 43. 50. 53. 57. 55. 50.

 91677 G 39. 41. 47. 49. 48. 54. 51. 57. 56.

 91679 G 54. 54. 55. 60. 58. 59. 60. 65. 61.

 91684 G 39. 44. 45. 54. 47. 53. 55. 46. 48.

 MEAN 43. 45. 47. 49. 50. 52. 53. 54. 53.

 S.D. 7.6 6.3 5.2 7.8 6.4 6.7 5.9 7.7 5.2

 S.E. 2.2 1.8 1.5 2.3 1.8 1.9 1.7 2.2 1.5

 N 12 12 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 674 of 1107
 TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 11

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 18-19 19-20 20-21 21-22 22-23 23-24 24-25 0- 4 4- 7

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91620 G 44. 45. 43. 44. NA NA NA 33. 39.

 91628 G 49. 42. 44. 30. NA NA NA 36. 37.

 91631 G 49. 49. 53. NA NA NA NA 35. 43.

 91636 G 55. 51. 46. 29. NA NA NA 57. 60.

 91649 G 45. 42. 40. 38. NA NA NA 29. 35.

 91650 G 60. 57. 48. 51. NA NA NA 36. 47.

 91656 G 47. 43. 43. 35. NA NA NA 36. 38.

 91671 G 61. 53. 52. 44. 7. NA NA 36. 40.

 91675 G 50. 46. 45. 37. NA NA NA 34. 41.

 91677 G 53. 51. 45. 40. 31. NA NA 31. 42.

 91679 G 60. 50. 56. 60. NA NA NA 48. 51.

 91684 G 43. 44. 36. 24. NA NA NA 34. 42.

 MEAN 51. 48. 46. 39. 19. NA NA 37. 43.

 S.D. 6.4 4.8 5.6 10.3 17.0 7.8 6.9

 S.E. 1.9 1.4 1.6 3.1 12.0 2.2 2.0

 N 12 12 12 11 2 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

NA = NOT APPLICABLE

Page 675 of 1107
 TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 12

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 7-11 11-14 14-17 17-20 0-20

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91620 G 37. 42. 48. 47. 40.

 91628 G 38. 41. 47. 47. 41.

 91631 G 45. 53. 54. 50. 46.

 91636 G 56. 56. 60. 54. 57.

 91649 G 33. 39. 42. 45. 36.

 91650 G 51. 54. 62. 59. 51.

 91656 G 40. 44. 46. 45. 41.

 91671 G 43. 52. 57. 58. 47.

 91675 G 39. 45. 55. 49. 43.

 91677 G 39. 48. 54. 53. 44.

 91679 G 52. 58. 61. 57. 54.

 91684 G 41. 49. 51. 45. 43.

 MEAN 43. 48. 53. 51. 45.

 S.D. 6.9 6.3 6.4 5.3 6.1

 S.E. 2.0 1.8 1.8 1.5 1.8

 N 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 676 of 1107
 TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 13

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 0- 1 1- 2 2- 3 3- 4 4- 5 5- 6 6- 7 7- 8 8- 9

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 4: 175 PPM

---------------------------------------

 91622 G 30. 39. 37. 41. 39. 38. 37. 34. 33.

 91626 G 35. 37. 45. 48. 43. 43. 43. 39. 44.

 91643 G 32. 33. 33. 31. 38. 38. 38. 37. 40.

 91654 G 37. 45. 45. 51. 51. 48. 52. 52. 48.

 91657 G 25. 41. 40. 41. 48. 46. 47. 47. 42.

 91662 G 22. 37. 34. 43. 43. 41. 42. 43. 37.

 91666 G 24. 29. 32. 32. 32. 36. 36. 33. 38.

 91676 G 24. 31. 31. 34. 36. 40. 35. 32. 37.

 91678 G 29. 45. 39. 48. 44. 45. 52. 47. 57.

 91681 G 36. 40. 50. 49. 50. 45. 51. 47. 46.

 91682 G 41. 43. 45. 47. 57. 46. 53. 59. 53.

 MEAN 30. 38. 39. 42. 44. 42. 44. 43. 43.

 S.D. 6.3 5.4 6.4 7.2 7.3 4.0 7.1 8.6 7.3

 S.E. 1.9 1.6 1.9 2.2 2.2 1.2 2.1 2.6 2.2

 N 11 11 11 11 11 11 11 11 11

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 677 of 1107
 TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 14

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 9-10 10-11 11-12 12-13 13-14 14-15 15-16 16-17 17-18

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 4: 175 PPM

---------------------------------------

 91622 G 36. 43. 50. 53. 52. 49. 57. 56. 46.

 91626 G 43. 46. 44. 52. 54. 53. 60. 59. 61.

 91643 G 41. 43. 43. 47. 48. 47. 50. 58. 53.

 91654 G 52. 56. 52. 59. 54. 62. 52. 61. 61.

 91657 G 47. 53. 53. 48. 58. 55. 57. 85. 59.

 91662 G 47. 49. 48. 47. 56. 55. 60. 66. 65.

 91666 G 38. 41. 41. 43. 46. 47. 53. 54. 50.

 91676 G 34. 41. 42. 47. 41. 43. 48. 45. 53.

 91678 G 60. 62. 56. 58. 70. 59. 65. 62. 77.

 91681 G 54. 58. 56. 60. 62. 57. 60. 69. 62.

 91682 G 56. 61. 62. 58. 69. 79. 70. 79. 78.

 MEAN 46. 50. 50. 52. 55. 55. 57. 63. 60.

 S.D. 8.6 8.1 6.8 6.0 9.0 9.8 6.5 11.3 10.2

 S.E. 2.6 2.4 2.0 1.8 2.7 2.9 2.0 3.4 3.1

 N 11 11 11 11 11 11 11 11 11

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 678 of 1107
 TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 15

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 18-19 19-20 20-21 21-22 22-23 23-24 24-25 0- 4 4- 7

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 4: 175 PPM

---------------------------------------

 91622 G 51. 47. 47. 52. NA NA NA 37. 38.

 91626 G 60. 56. 51. 49. NA NA NA 41. 43.

 91643 G 57. 49. 53. 49. NA NA NA 32. 38.

 91654 G 58. 51. 54. 45. 46. NA NA 45. 50.

 91657 G 71. 63. 51. 59. NA NA NA 37. 47.

 91662 G 68. 56. 52. 42. NA NA NA 34. 42.

 91666 G 49. 44. 42. 41. NA NA NA 29. 35.

 91676 G 43. 40. 45. 40. NA NA NA 30. 37.

 91678 G 65. 57. 70. 60. NA NA NA 40. 47.

 91681 G 59. 56. 47. 48. 3. NA NA 44. 49.

 91682 G 80. 66. 65. 55. 49. NA NA 44. 52.

 MEAN 60. 53. 52. 49. 33. NA NA 38. 43.

 S.D. 10.6 7.9 8.3 6.9 25.7 5.8 5.9

 S.E. 3.2 2.4 2.5 2.1 14.9 1.7 1.8

 N 11 11 11 11 3 11 11

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

NA = NOT APPLICABLE

Page 679 of 1107
 TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 16

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 7-11 11-14 14-17 17-20 0-20

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 4: 175 PPM

---------------------------------------

 91622 G 37. 52. 54. 48. 43.

 91626 G 43. 50. 57. 59. 48.

 91643 G 40. 46. 52. 53. 43.

 91654 G 52. 55. 58. 57. 52.

 91657 G 47. 53. 66. 64. 51.

 91662 G 44. 50. 60. 63. 48.

 91666 G 38. 43. 51. 48. 40.

 91676 G 36. 43. 45. 45. 39.

 91678 G 57. 61. 62. 66. 55.

 91681 G 51. 59. 62. 59. 53.

 91682 G 57. 63. 76. 75. 60.

 MEAN 46. 52. 58. 58. 48.

 S.D. 7.7 6.8 8.3 9.0 6.6

 S.E. 2.3 2.1 2.5 2.7 2.0

 N 11 11 11 11 11

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 680 of 1107
 TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 17

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 0- 1 1- 2 2- 3 3- 4 4- 5 5- 6 6- 7 7- 8 8- 9

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91624 G 31. 33. 37. 37. 44. 40. 38. 42. 39.

 91625 G 29. 34. 33. 33. 38. 33. 34. 33. 31.

 91627 G NA 38. 45. 40. 38. 38. 44. NA 42.

 91634 G 28. 30. 31. 30. 30. 34. 33. 30. 35.

 91635 G 21. 32. 30. 33. 34. 36. 34. 30. 32.

 91638 G 30. 30. 31. 29. 32. 32. 29. 33. 33.

 91652 G 29. 32. 38. 32. 32. 34. 34. 37. 35.

 91655 G 23. 28. 31. 28. 31. 29. 32. 32. 29.

 91658 G 25. 31. 35. 38. 37. 36. 32. 35. 32.

 91667 G 29. 34. 36. 36. 41. 43. 34. 32. 37.

 91668 G 27. 34. 29. 32. 35. 39. 35. 35. 33.

 91680 G 27. 23. 34. 30. 28. 26. 31. 25. 28.

 MEAN 27. 32. 34. 33. 35. 35. 34. 33. 34.

 S.D. 3.1 3.7 4.5 3.8 4.7 4.7 3.8 4.3 4.0

 S.E. 0.9 1.1 1.3 1.1 1.4 1.4 1.1 1.3 1.2

 N 11 12 12 12 12 12 12 11 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

NA = NOT APPLICABLE

Page 681 of 1107
 TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 18

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 9-10 10-11 11-12 12-13 13-14 14-15 15-16 16-17 17-18

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91624 G 38. 44. 49. 41. 47. 47. 50. 52. 51.

 91625 G 37. 37. 35. 40. 39. 42. 37. 46. 42.

 91627 G 48. 39. 53. 52. 43. 56. 58. 56. 51.

 91634 G 35. 37. 38. 39. 44. 40. 44. 51. 49.

 91635 G 33. 35. 38. 40. 44. 38. 40. 41. 40.

 91638 G 32. NA 35. 34. 38. 37. 39. 45. 45.

 91652 G 36. 39. 41. 44. 45. 45. 49. 54. 49.

 91655 G 36. 35. 44. 45. 50. 50. 50. 54. 50.

 91658 G 33. 39. 37. 43. 42. 39. 42. 42. 48.

 91667 G 33. 37. 37. 37. 37. 43. 43. 48. 47.

 91668 G 32. 39. 37. 43. 36. 45. 41. 47. 48.

 91680 G 31. 37. 33. 41. 43. 43. 49. 46. 47.

 MEAN 35. 38. 40. 42. 42. 44. 45. 49. 47.

 S.D. 4.6 2.5 6.0 4.5 4.2 5.4 6.1 4.9 3.4

 S.E. 1.3 0.8 1.7 1.3 1.2 1.6 1.8 1.4 1.0

 N 12 11 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

NA = NOT APPLICABLE

Page 682 of 1107
 TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 19

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 18-19 19-20 20-21 21-22 22-23 23-24 24-25 0- 4 4- 7

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91624 G 44. 47. 42. 36. NA NA NA 35. 41.

 91625 G 45. 41. 37. 23. NA NA NA 32. 35.

 91627 G 56. 50. 52. 44. NA NA NA 41. 40.

 91634 G 49. 45. 39. 39. NA NA NA 30. 32.

 91635 G 45. 39. 36. 32. NA NA NA 29. 35.

 91638 G 43. 41. 42. 27. NA NA NA 30. 31.

 91652 G 52. 50. 43. 47. NA NA NA 33. 33.

 91655 G 54. 45. 45. 34. NA NA NA 28. 31.

 91658 G 34. 40. 43. NA NA NA NA 32. 35.

 91667 G 38. 36. 43. NA NA NA NA 34. 39.

 91668 G 43. 43. 48. 39. NA NA NA 31. 36.

 91680 G 43. 44. 32. NA NA NA NA 29. 28.

 MEAN 46. 43. 42. 36. NA NA NA 32. 35.

 S.D. 6.4 4.3 5.4 7.7 3.5 3.9

 S.E. 1.8 1.2 1.6 2.6 1.0 1.1

 N 12 12 12 9 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

NA = NOT APPLICABLE

Page 683 of 1107
 TABLE A29 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 20

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 7-11 11-14 14-17 17-20 0-20

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91624 G 41. 46. 50. 47. 43.

 91625 G 35. 38. 42. 43. 37.

 91627 G 43. 49. 57. 52. 47.

 91634 G 34. 40. 45. 48. 38.

 91635 G 33. 41. 40. 41. 36.

 91638 G 33. 36. 40. 43. 35.

 91652 G 37. 43. 49. 50. 40.

 91655 G 33. 46. 51. 50. 39.

 91658 G 35. 41. 41. 41. 37.

 91667 G 35. 37. 45. 40. 38.

 91668 G 35. 39. 44. 45. 38.

 91680 G 30. 39. 46. 45. 35.

 MEAN 35. 41. 46. 45. 39.

 S.D. 3.6 4.0 5.1 4.0 3.4

 S.E. 1.0 1.2 1.5 1.2 1.0

 N 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

 PGFWv4.11

 01/16/2014

Page 684 of 1107
 TABLE A30 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 0- 4 4- 7 7-11 11-14 14-17 17-20 0-20

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91629 G 122. 119. 117. 120. 118. 106. 117.

 91630 G 127. 124. 120. 123. 144. 142. 129.

 91633 G 90. 91. 104. 108. 117. 96. 101.

 91637 G 124. 128. 116. 121. 122. 107. 119.

 91639 G 98. 128. 136. 131. 189. 136. 136.

 91644 G 129. 119. 188. 198. 157. 124. 147.

 91645 G 115. 115. 123. 120. 118. 107. 114.

 91648 G 98. 105. 101. 114. 116. 102. 105.

 91653 G 117. 113. 111. 116. 116. 116. 114.

 91660 G 96. 97. 99. 97. 104. 95. 97.

 91670 G 121. 121. 121. 124. 127. 120. 121.

 91672 G 106. 109. 117. 108. 114. 104. 108.

 MEAN 112. 114. 121. 123. 129. 113. 117.

 S.D. 13.6 11.7 23.4 25.2 23.8 15.0 14.5

 S.E. 3.9 3.4 6.8 7.3 6.9 4.3 4.2

 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 685 of 1107
 TABLE A30 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 0- 4 4- 7 7-11 11-14 14-17 17-20 0-20

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91632 G 93. 86. 89. 93. 95. 94. 90.

 91640 G 96. 109. 105. 125. 131. 120. 114.

 91642 G 95. 92. 91. 100. 101. 98. 94.

 91647 G 153. 161. 158. 158. 158. 146. 153.

 91651 G 100. 98. 90. 105. 101. 99. 98.

 91659 G 113. 109. 120. 120. 135. 125. 120.

 91661 G 149. 148. 139. 159. 160. 133. 145.

 91663 G 130. 130. 132. 124. 127. 111. 124.

 91669 G 115. 133. 104. 105. 113. 103. 109.

 91673 G 100. 107. 99. 112. 130. 122. 108.

 91683 G 139. 116. 125. 140. 165. 152. 137.

 91685 G 132. 136. 132. 145. 142. 111. 131.

 MEAN 118. 119. 115. 124. 130. 118. 119.

 S.D. 21.9 23.0 22.3 22.4 23.9 18.8 20.2

 S.E. 6.3 6.6 6.4 6.5 6.9 5.4 5.8

 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 686 of 1107
 TABLE A30 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 0- 4 4- 7 7-11 11-14 14-17 17-20 0-20

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91620 G 108. 120. 108. 117. 126. 112. 112.

 91628 G 137. 134. 131. 134. 142. 125. 132.

 91631 G 114. 132. 130. 144. 137. 114. 126.

 91636 G 216. 208. 186. 177. 178. 145. 182.

 91649 G 109. 125. 111. 124. 123. 115. 113.

 91650 G 126. 154. 155. 156. 167. 142. 148.

 91656 G 113. 117. 119. 125. 123. 109. 115.

 91671 G 114. 119. 123. 143. 148. 135. 129.

 91675 G 112. 127. 115. 127. 146. 118. 121.

 91677 G 109. 138. 124. 148. 158. 148. 137.

 91679 G 156. 156. 152. 161. 159. 137. 151.

 91684 G 125. 149. 138. 155. 151. 117. 135.

 MEAN 128. 140. 133. 143. 147. 126. 133.

 S.D. 31.1 25.3 22.4 17.9 17.5 14.1 19.9

 S.E. 9.0 7.3 6.5 5.2 5.0 4.1 5.7

 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 687 of 1107
 TABLE A30 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 0- 4 4- 7 7-11 11-14 14-17 17-20 0-20

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 4: 175 PPM

---------------------------------------

 91622 G 139. 134. 125. 166. 162. 129. 137.

 91626 G 136. 136. 130. 144. 153. 142. 137.

 91643 G 102. 117. 116. 127. 134. 123. 118.

 91654 G 156. 164. 164. 166. 163. 143. 155.

 91657 G 112. 137. 131. 142. 166. 146. 136.

 91662 G 112. 132. 134. 147. 168. 158. 140.

 91666 G 112. 129. 133. 143. 160. 136. 134.

 91676 G 113. 131. 120. 136. 133. 119. 124.

 91678 G 120. 132. 150. 154. 149. 145. 141.

 91681 G 148. 158. 157. 175. 173. 146. 155.

 91682 G 141. 159. 167. 176. 201. 181. 168.

 MEAN 126. 139. 139. 152. 160. 143. 140.

 S.D. 18.0 14.7 17.7 16.3 18.8 17.1 14.3

 S.E. 5.4 4.4 5.3 4.9 5.7 5.1 4.3

 N 11 11 11 11 11 11 11

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

Page 688 of 1107
 TABLE A30 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING GESTATION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 PREGNANCY

 STATUS DAY 0- 4 4- 7 7-11 11-14 14-17 17-20 0-20

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91624 G 125. 136. 131. 142. 144. 121. 131.

 91625 G 121. 126. 121. 124. 129. 118. 121.

 91627 G 150. 141. 146. 159. 173. 140. 150.

 91634 G 109. 108. 109. 122. 129. 124. 117.

 91635 G 102. 116. 103. 121. 110. 101. 107.

 91638 G 103. 100. 102. 107. 112. 109. 104.

 91652 G 116. 106. 110. 120. 130. 120. 115.

 91655 G 102. 105. 107. 143. 147. 128. 120.

 91658 G 112. 117. 112. 125. 118. 108. 113.

 91667 G 115. 126. 108. 109. 122. 98. 111.

 91668 G 108. 118. 108. 112. 117. 108. 110.

 91680 G 105. 97. 100. 122. 134. 117. 109.

 MEAN 114. 116. 113. 126. 130. 116. 117.

 S.D. 13.6 13.9 13.4 15.3 17.7 11.9 12.6

 S.E. 3.9 4.0 3.9 4.4 5.1 3.4 3.6

 N 12 12 12 12 12 12 12

G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

 PGFWv4.11

 01/16/2014

Page 689 of 1107
 TABLE A31 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING LACTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 0- 1 1- 2 2- 3 3- 4 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91629 NA 29. 52. 59. 47.

 91630 34. 40. 55. 68. 54.

 91633 NA 29. 47. 47. 41.

 91637 NA 43. 55. 60. 53.

 91639 NA 40. 56. 60. 52.

 91644 NA 62. 88. 99. 83.

 91645 38. 58. 67. 84. 70.

 91648 NA 43. 65. 53. 54.

 91653 38. 49. 58. 73. 60.

 91660 NA 53. 65. 63. 60.

 91670 54. 53. 98. 131. 94.

 91672 41. 59. 65. 58. 61.

 MEAN 41. 47. 64. 71. 61.

 S.D. 7.7 11.0 14.9 23.5 15.1

 S.E. 3.4 3.2 4.3 6.8 4.3

 N 5 12 12 12 12

NA = NOT APPLICABLE

Page 690 of 1107
 TABLE A31 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING LACTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 0- 1 1- 2 2- 3 3- 4 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91632 NA 34. 44. 49. 42.

 91640 NA 47. 54. 62. 54.

 91642 NA 42. 52. 47. 47.

 91647 NA 36. 46. 57. 46.

 91651 39. 42. 60. 56. 53.

 91659 NA 44. 51. 68. 54.

 91661 39. 55. 65. 52. 57.

 91663 NA 37. 52. 55. 48.

 91669 NA 39. 69. 63. 57.

 91673 NA 32. 47. NA 40.

 91683 NA 29. 49. 57. 45.

 91685 NA 25. 39. 47. 37.

 MEAN 39. 39. 52. 56. 48.

 S.D. 0.0 8.2 8.7 6.8 6.7

 S.E. 0.0 2.4 2.5 2.0 1.9

 N 2 12 12 11 12

NA = NOT APPLICABLE

Page 691 of 1107
 TABLE A31 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING LACTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 0- 1 1- 2 2- 3 3- 4 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91620 33. 54. 64. 65. 61.

 91628 NA 44. 47. 51. 47.

 91631 19. 44. 57. 64. 55.

 91636 NA 31. 42. 48. 40.

 91649 NA 44. 50. 49. 48.

 91650 NA 45. 56. 75. 59.

 91656 NA 41. 49. 48. 46.

 91671 23. 37. 51. 57. 48.

 91675 37. 42. 57. 63. 54.

 91677 NA 22. 33. 31. 29.

 91679 NA 42. 49. 47. 46.

 91684 NA 31. 42. 40. 38.

 MEAN 28. 40. 50. 53. 48.

 S.D. 8.4 8.4 8.3 12.1 9.1

 S.E. 4.2 2.4 2.4 3.5 2.6

 N 4 12 12 12 12

NA = NOT APPLICABLE

Page 692 of 1107
 TABLE A31 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING LACTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 0- 1 1- 2 2- 3 3- 4 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 4: 175 PPM

---------------------------------------

 91622 NA 36. 47. 42. 42.

 91626 NA 51. 60. 75. 62.

 91643 NA 37. 51. 46. 45.

 91654 NA 13. NA NA NA

 91657 NA 23. 40. 36. 33.

 91662 46. 34. 38. 41. 38.

 91666 18. 37. 41. 43. 40.

 91676 32. 46. 39. 49. 45.

 91678 34. 51. 66. 84. 67.

 91681 35. 51. 57. 81. 63.

 91682 NA 15. 30. 35. 27.

 MEAN 33. 36. 47. 53. 46.

 S.D. 10.0 13.9 11.4 19.1 13.5

 S.E. 4.5 4.2 3.6 6.0 4.3

 N 5 11 10 10 10

NA = NOT APPLICABLE

Page 693 of 1107
 TABLE A31 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING LACTATION [G/ANIMAL/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 0- 1 1- 2 2- 3 3- 4 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91624 NA 39. 46. 50. 45.

 91625 36. 48. 65. 60. 58.

 91627 NA 41. 53. 48. 47.

 91634 NA 45. 64. NA 55.

 91635 NA 41. 57. 55. 51.

 91638 NA 42. 57. 66. 55.

 91652 NA 39. 56. 56. 50.

 91655 NA 35. 34. 45. 38.

 91658 23. 46. 50. 55. 50.

 91667 34. 47. 59. 71. 59.

 91668 NA 37. 50. 54. 47.

 91680 29. 43. 51. 62. 52.

 MEAN 31. 42. 54. 57. 51.

 S.D. 5.8 4.1 8.4 7.8 5.9

 S.E. 2.9 1.2 2.4 2.3 1.7

 N 4 12 12 11 12

NA = NOT APPLICABLE

 PLFWv4.13

 01/16/2014

Page 694 of 1107
 TABLE A32 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING LACTATION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91629 160.

 91630 171.

 91633 116.

 91637 172.

 91639 146.

 91644 272.

 91645 207.

 91648 151.

 91653 180.

 91660 172.

 91670 281.

 91672 163.

 MEAN 183.

 S.D. 48.9

 S.E. 14.1

 N 12

Page 695 of 1107
 TABLE A32 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING LACTATION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91632 135.

 91640 153.

 91642 137.

 91647 158.

 91651 163.

 91659 148.

 91661 183.

 91663 147.

 91669 187.

 91673 125.

 91683 141.

 91685 128.

 MEAN 150.

 S.D. 19.8

 S.E. 5.7

 N 12

Page 696 of 1107
 TABLE A32 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING LACTATION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91620 176.

 91628 168.

 91631 158.

 91636 137.

 91649 160.

 91650 170.

 91656 140.

 91671 142.

 91675 154.

 91677 94.

 91679 138.

 91684 133.

 MEAN 148.

 S.D. 22.2

 S.E. 6.4

 N 12

Page 697 of 1107
 TABLE A32 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING LACTATION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 4: 175 PPM

---------------------------------------

 91622 143.

 91626 177.

 91643 127.

 91654 NA

 91657 93.

 91662 115.

 91666 142.

 91676 143.

 91678 173.

 91681 197.

 91682 81.

 MEAN 139.

 S.D. 36.8

 S.E. 11.6

 N 10

NA = NOT APPLICABLE

Page 698 of 1107
 TABLE A32 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL WATER CONSUMPTION DURING LACTATION [G/KG/DAY]

-----------------------------------------------------------------------------------------------------------------------------------

 DAY 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91624 139.

 91625 203.

 91627 156.

 91634 172.

 91635 157.

 91638 177.

 91652 143.

 91655 123.

 91658 162.

 91667 176.

 91668 142.

 91680 170.

 MEAN 160.

 S.D. 21.5

 S.E. 6.2

 N 12

 PLFWv4.13

 01/16/2014

Page 699 of 1107
 TABLE A33 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ESTROUS CYCLE DATA

-----------------------------------------------------------------------------------------------------------------------------------

FEMALES FROM GROUP 1: 0 PPM INDIVIDUAL

-------------------------------------- MEAN LENGTH

FEMALE DETERMINATION 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 OF ESTRUS

NUMBER DAY: 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 CYCLE (DAYS)

-----------------------------------------------------------------------------------------------------------------------------------

 T B

-----------------------------------------------------------------------------------------------------------------------------------

 91629 D D P E D D P E D D P E D D D E D D D E D D P E D D D + 4.0

 91630 D D D E D D D E D D D E D D D E D D D E D D D E D D P C 4.0

 91633 D E D D D D D E D D D P E D D D D D D D P D D D E C 8.0

 91637 E D D D E D D D E D D D E D D D E D D D E M D D + 4.0

 91639 D E D D D E D D D E D D D P E D D D E D D D E D D D C 4.3

 91644 E D D P E D D P E D D D E D D D E D D P E E D D E C 4.5

 91645 D D D E D D P E D D D E D D D E D D P E D D P E E D P C 4.3

 91648 E D D D E D D D E D D D E D D D E D D P E E D D + 4.5

 91653 D D D E D D P E E D D P E D D D D E D D P E E D D P C 5.0

 91660 D D D D P E D D D P E D D D D D D D D D D D E D D D C 12.0

 91670 D D D E D D P E D D D E D D D E D D P E D D D E D D D C 4.0

 91672 D D D E D D D E D D D E D D D E D D D E D D D E - D D C 4.0

 MEAN 5.2

 S.D. 2.41

 S.E. 0.70

 N 12

-----------------------------------------------------------------------------------------------------------------------------------

ESTROUS STAGE CODE: E = ESTRUS, D = DIESTRUS, M = METESTRUS, P = PROESTRUS

T = FIRST DAY OF TREATMENT, B = FIRST DAY OF BREEDING PERIOD

C = COPULATORY PLUG OBSERVED, + = SMEARED POSITIVE, - = SMEARED NEGATIVE

Page 700 of 1107
 TABLE A33 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ESTROUS CYCLE DATA

-----------------------------------------------------------------------------------------------------------------------------------

FEMALES FROM GROUP 2: 50 PPM INDIVIDUAL

-------------------------------------- MEAN LENGTH

FEMALE DETERMINATION 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 OF ESTRUS

NUMBER DAY: 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 CYCLE (DAYS)

-----------------------------------------------------------------------------------------------------------------------------------

 T B

-----------------------------------------------------------------------------------------------------------------------------------

 91632 D E D D D E D D D E E D D D P E D D P E D D D E E D D P C 4.7

 91640 D D D E D D D P E D D D P D D D D D E D D D P E D D D P C 5.5

 91642 D D D E D D D E D D D E D D D E D D D E E D D D E C 4.5

 91647 D D D E D D D E D D D E D D D E D D D E D D D E D D D C 4.0

 91651 D D E D D D E D D D E D D D P E D D D E E D D D E C 5.0

 91659 D D D E D D D E D D D P D D D E E D D D E D D D E C 4.5

 91661 E D D D E D D D E D D D E D D P E D D P E D D P C 4.0

 91663 D E D D D E D D D E D D D E D D D E E D D D D D D D C 4.5

 91669 D D D E D D P E D D D E D D D P E D D P D D D E C 4.0

 91673 D D P E D D D E D D D E D D D E D D P E D D D E D D D + 4.0

 91683 E D D D E D D D E D D D E E D D D P E D D D E E D D D E C 5.0

 91685 D D E D D D E D D D E D D D P E D D D E E D D P C 5.0

 MEAN 4.6

 S.D. 0.50

 S.E. 0.14

 N 12

-----------------------------------------------------------------------------------------------------------------------------------

ESTROUS STAGE CODE: E = ESTRUS, D = DIESTRUS, M = METESTRUS, P = PROESTRUS

T = FIRST DAY OF TREATMENT, B = FIRST DAY OF BREEDING PERIOD

C = COPULATORY PLUG OBSERVED, + = SMEARED POSITIVE

Page 701 of 1107
 TABLE A33 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ESTROUS CYCLE DATA

-----------------------------------------------------------------------------------------------------------------------------------

FEMALES FROM GROUP 3: 100 PPM INDIVIDUAL

-------------------------------------- MEAN LENGTH

FEMALE DETERMINATION 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 OF ESTRUS

NUMBER DAY: 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 CYCLE (DAYS)

-----------------------------------------------------------------------------------------------------------------------------------

 T B

-----------------------------------------------------------------------------------------------------------------------------------

 91620 D D D E D D D E D D D E D D D E E D D D P E D D D E C 5.0

 91628 E D D D E D D D E D D D E D D D E D D D E E D D D C 4.5

 91631 D D D E D D D E D D D E D D D E E D D D E E D D D C 5.0

 91636 D E D D P E D D D E D D P E D D P E D D P E E D D P + 4.3

 91649 D E D D D E D D D E D D D E D D D P E E D D D E + 5.0

 91650 D E D D D E D D D E D D D P E D D D P E D D D E + 5.0

 91656 D D D E D D D E D D D E D D D E E D D D D D D D D D D D P + 5.0

 91671 E D D D P E D D D P E D D D P E E D D D D P E D D D P E C 6.0

 91675 D E D D D E D D D E D D D P E D D D E E D D P E C 5.0

 91677 D D E D D D E D D P E D D D E E D D D E E D D D E C 5.0

 91679 P E D D D E D D D E D D D E E D D P E E D D P E C 5.0

 91684 E D D D E D D D E D D D E D D D P D D D D E D D D C 4.5

 MEAN 4.9

 S.D. 0.42

 S.E. 0.12

 N 12

-----------------------------------------------------------------------------------------------------------------------------------

ESTROUS STAGE CODE: E = ESTRUS, D = DIESTRUS, M = METESTRUS, P = PROESTRUS

T = FIRST DAY OF TREATMENT, B = FIRST DAY OF BREEDING PERIOD

C = COPULATORY PLUG OBSERVED, + = SMEARED POSITIVE

Page 702 of 1107
 TABLE A33 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ESTROUS CYCLE DATA

-----------------------------------------------------------------------------------------------------------------------------------

FEMALES FROM GROUP 4: 175 PPM INDIVIDUAL

-------------------------------------- MEAN LENGTH

FEMALE DETERMINATION 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 OF ESTRUS

NUMBER DAY: 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 CYCLE (DAYS)

-----------------------------------------------------------------------------------------------------------------------------------

 T B

-----------------------------------------------------------------------------------------------------------------------------------

 91622 P E D D D E D D D E D D D E E D D D E E D D D E C 5.0

 91623 E D D D E D D D E D D D E D D D E E D D D E E D D D P E D D D D D D D D D D D 5.0

 91626 E D D D E D D D E D D D E D D D E E D D D P E D D D E C 5.0

 91643 E D D D E D D D E D D D E E D D D P E E D D D D E E E D D E C 6.5

 91654 D D E D D P E D D D E D D D E E D D D D D D D D E D D D P C 7.0

 91657 D D D E D D D E D D D E D D D P D D D D E E D D D D D D D D D D D D P C 5.0

 91662 D D D E D D D E D D D E D D D E E D D D P E D D D D C 5.0

 91666 D E D D D E D D D E D D D E D D D D E E D D D D C 5.0

 91676 D D E D D D E D D D E D D D P E D D D P E D D D D C 5.0

 91678 D P E D D D E D D D E D D D E E D D E E D D D E + 4.5

 91681 E D D D E D D D E D D D E D D E E E E D P D P D D D D D D D D D P C 3.3

 91682 D D P E D D P E D D D E D D D D E D P D P E D D P E C 3.3

 MEAN 5.0

 S.D. 1.05

 S.E. 0.30

 N 12

-----------------------------------------------------------------------------------------------------------------------------------

ESTROUS STAGE CODE: E = ESTRUS, D = DIESTRUS, M = METESTRUS, P = PROESTRUS

T = FIRST DAY OF TREATMENT, B = FIRST DAY OF BREEDING PERIOD

C = COPULATORY PLUG OBSERVED, + = SMEARED POSITIVE

Page 703 of 1107
 TABLE A33 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ESTROUS CYCLE DATA

-----------------------------------------------------------------------------------------------------------------------------------

FEMALES FROM GROUP 5: 10000 PPM INDIVIDUAL

-------------------------------------- MEAN LENGTH

FEMALE DETERMINATION 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 OF ESTRUS

NUMBER DAY: 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 CYCLE (DAYS)

-----------------------------------------------------------------------------------------------------------------------------------

 T B

-----------------------------------------------------------------------------------------------------------------------------------

 91624 D D E D D P E D D D E D D D E D D D E D D D E D D P C 4.0

 91625 E D D D E D D D E D D D E E D D D P E D D D E D D D C 4.5

 91627 D E D D D E D D D E D D D P E D D D E E D D D E + 5.0

 91634 E D D D E D D D E D D D E D D D D D D D D E E D D D E C 10.0

 91635 D D D E D D D E D D D E D D D P E D D D E D D D C 4.5

 91638 D D D E D D D E D D D E D D D E E D D P E E D D D P + 5.0

 91652 D D D E D D D E D D D E D D D E E D D D E D D D + 4.5

 91655 D D E D D D E D D D E D D D E D D D E E D D D E C 4.5

 91658 D E D D D E D D D E D D D D D D D D D D D D D D P C A

 91667 D D D E D D D E D D D E D D D E E D D D E E D D D C 5.0

 91668 D D D E D D D E D D D E D D D E E D D D E E D D D C 5.0

 91680 E D D D E D D D E D D D E D D D E D D D E D D D C 4.0

 MEAN 5.1

 S.D. 1.67

 S.E. 0.50

 N 11

-----------------------------------------------------------------------------------------------------------------------------------

ESTROUS STAGE CODE: E = ESTRUS, D = DIESTRUS, M = METESTRUS, P = PROESTRUS

T = FIRST DAY OF TREATMENT, B = FIRST DAY OF BREEDING PERIOD

A = UNABLE TO DETERMINE LENGTH OF ESTROUS CYCLE

C = COPULATORY PLUG OBSERVED, + = SMEARED POSITIVE

 PCYCv5.29

 01/07/2014

Page 704 of 1107
 TABLE A34 (F0)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL REPRODUCTIVE PERFORMANCE

-----------------------------------------------------------------------------------------------------------------------------------

GROUP 1: 0 PPM

 FEMALE FIRST SECOND DAYS PREGNANCY

 NUMBER MALE DATE MALE DATE PRE-COITUS STATUS

-----------------------------------------------------------------------------------------------------------------------------------

 91629 91555 10/27/13 4 G

 91630 91560 10/27/13 4 G

 91633 91562 10/27/13 2 G

 91637 91563 10/27/13 1 G

 91639 91564 10/27/13 3 G

 91644 91567 10/27/13 2 G

 91645 91579 10/27/13 4 G

 91648 91586 10/27/13 1 G

 91653 91591 10/27/13 3 G

 91660 91592 10/27/13 3 G

 91670 91609 10/27/13 4 G

 91672 91615 10/27/13 4 G

-----------------------------------------------------------------------------------------------------------------------------------

G = GRAVID

Page 705 of 1107
 TABLE A34 (F0)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL REPRODUCTIVE PERFORMANCE

-----------------------------------------------------------------------------------------------------------------------------------

GROUP 2: 50 PPM

 FEMALE FIRST SECOND DAYS PREGNANCY

 NUMBER MALE DATE MALE DATE PRE-COITUS STATUS

-----------------------------------------------------------------------------------------------------------------------------------

 91632 91556 10/27/13 5 G

 91640 91559 10/27/13 5 G

 91642 91561 10/27/13 2 G

 91647 91566 10/27/13 4 G

 91651 91576 10/27/13 2 G

 91659 91582 10/27/13 2 G

 91661 91585 10/27/13 1 G

 91663 91589 10/27/13 3 G

 91669 91593 10/27/13 1 G

 91673 91594 10/27/13 4 G

 91683 91595 10/27/13 5 G

 91685 91602 10/27/13 1 G

-----------------------------------------------------------------------------------------------------------------------------------

G = GRAVID

Page 706 of 1107
 TABLE A34 (F0)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL REPRODUCTIVE PERFORMANCE

-----------------------------------------------------------------------------------------------------------------------------------

GROUP 3: 100 PPM

 FEMALE FIRST SECOND DAYS PREGNANCY

 NUMBER MALE DATE MALE DATE PRE-COITUS STATUS

-----------------------------------------------------------------------------------------------------------------------------------

 91620 91569 10/27/13 3 G

 91628 91573 10/27/13 2 G

 91631 91577 10/27/13 2 G

 91636 91581 10/27/13 3 G

 91649 91583 10/27/13 1 G

 91650 91588 10/27/13 1 G

 91656 91590 10/27/13 6 G

 91671 91598 10/27/13 5 G

 91675 91599 10/27/13 1 G

 91677 91608 10/27/13 2 G

 91679 91611 10/27/13 1 G

 91684 91616 10/27/13 2 G

-----------------------------------------------------------------------------------------------------------------------------------

G = GRAVID

Page 707 of 1107
 TABLE A34 (F0)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL REPRODUCTIVE PERFORMANCE

-----------------------------------------------------------------------------------------------------------------------------------

GROUP 4: 175 PPM

 FEMALE FIRST SECOND DAYS PREGNANCY

 NUMBER MALE DATE MALE DATE PRE-COITUS STATUS

-----------------------------------------------------------------------------------------------------------------------------------

 91622 91565 10/27/13 1 G

 91623 91568 10/27/13 B NG

 91626 91570 10/27/13 4 G

 91643 91572 10/27/13 7 G

 91654 91580 10/27/13 6 G

 91657 91584 10/27/13 12 G

 91662 91587 10/27/13 3 G

 91666 91597 10/27/13 1 G

 91676 91601 10/27/13 2 G

 91678 91607 10/27/13 1 G

 91681 91613 10/27/13 10 G

 91682 91614 10/27/13 3 G

-----------------------------------------------------------------------------------------------------------------------------------

B = NO EVIDENCE OF MATING, G = GRAVID, NG = NONGRAVID

Page 708 of 1107
 TABLE A34 (F0)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL REPRODUCTIVE PERFORMANCE

-----------------------------------------------------------------------------------------------------------------------------------

GROUP 5: 10000 PPM

 FEMALE FIRST SECOND DAYS PREGNANCY

 NUMBER MALE DATE MALE DATE PRE-COITUS STATUS

-----------------------------------------------------------------------------------------------------------------------------------

 91624 91554 10/27/13 3 G

 91625 91557 10/27/13 3 G

 91627 91558 10/27/13 1 G

 91634 91571 10/27/13 4 G

 91635 91575 10/27/13 1 G

 91638 91600 10/27/13 3 G

 91652 91603 10/27/13 1 G

 91655 91604 10/27/13 1 G

 91658 91605 10/27/13 2 G

 91667 91612 10/27/13 2 G

 91668 91618 10/27/13 2 G

 91680 91619 10/27/13 1 G

-----------------------------------------------------------------------------------------------------------------------------------

G = GRAVID

 PPAIRv4.09

 01/07/2014

 R:01/07/2014

Page 709 of 1107
 TABLE A35 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL GESTATION LENGTHS [DAYS]

-----------------------------------------------------------------------------------------------------------------------------------

GROUP: 1 2 3 4 5

-----------------------------------------------------------------------------------------------------------------------------------

 GESTATION GESTATION GESTATION GESTATION GESTATION

ANIMAL LENGTH ANIMAL LENGTH ANIMAL LENGTH ANIMAL LENGTH ANIMAL LENGTH

-----------------------------------------------------------------------------------------------------------------------------------

91629 21. 91632 22. 91620 23. 91622 22. 91624 22.

91630 22. 91640 22. 91628 22. 91626 22. 91625 23.

91633 21. 91642 22. 91631 22. 91643 22. 91627 22.

91637 21. 91647 22. 91636 22. 91654 23. 91634 22.

91639 22. 91651 23. 91649 22. 91657 22. 91635 22.

91644 21. 91659 22. 91650 22. 91662 23. 91638 22.

91645 22. 91661 22. 91656 22. 91666 23. 91652 22.

91648 22. 91663 22. 91671 23. 91676 23. 91655 22.

91653 22. 91669 22. 91675 23. 91678 23. 91658 22.

91660 22. 91673 22. 91677 23. 91681 23. 91667 22.

91670 22. 91683 22. 91679 22. 91682 23. 91668 22.

91672 22. 91685 22. 91684 22. 91680 22.

-----------------------------------------------------------------------------------------------------------------------------------

MEAN 21.7 22.1 22.3 22.6 22.1

S.D. 0.49 0.29 0.49 0.50 0.29

S.E. 0.14 0.08 0.14 0.15 0.08

 N 12 12 12 11 12

-----------------------------------------------------------------------------------------------------------------------------------

 1- 0 PPM 2- 50 PPM 3- 100 PPM 4- 175 PPM 5- 10000 PPM

 PGLv5.10

 01/07/2014

Page 710 of 1107
 TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91629 F 0 PPM PARTURITION OBS 20 11/20/13 7:30 P NO PRE-DELIVERY FINDINGS

 20 11/20/13 15:04 P NO PRE-DELIVERY FINDINGS

 21 11/21/13 7:30 P NO PRE-DELIVERY FINDINGS

 21 11/21/13 13:34 P PUPS PRESENT IN NESTING BOX

 21 11/21/13 13:41 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 22 11/22/13 8:09 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91630 F 0 PPM PARTURITION OBS 20 11/20/13 7:31 P NO PRE-DELIVERY FINDINGS

 20 11/20/13 15:04 P NO PRE-DELIVERY FINDINGS

 21 11/21/13 7:30 P NO PRE-DELIVERY FINDINGS

 21 11/21/13 13:34 P NO PRE-DELIVERY FINDINGS

 22 11/22/13 7:30 P PUPS PRESENT IN NESTING BOX

 22 11/22/13 9:06 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91633 F 0 PPM PARTURITION OBS 20 11/18/13 7:30 P NO PRE-DELIVERY FINDINGS

 20 11/18/13 15:27 P NO PRE-DELIVERY FINDINGS

 21 11/19/13 7:31 P NO PRE-DELIVERY FINDINGS

 21 11/19/13 13:32 P PUPS PRESENT IN NESTING BOX

 21 11/19/13 13:42 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 22 11/20/13 6:29 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91637 F 0 PPM PARTURITION OBS 20 11/17/13 7:31 P NO PRE-DELIVERY FINDINGS

 20 11/17/13 14:28 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 7:31 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 13:42 P PUPS PRESENT IN NESTING BOX

 21 11/18/13 14:02 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91639 F 0 PPM PARTURITION OBS 20 11/19/13 7:32 P NO PRE-DELIVERY FINDINGS

 20 11/19/13 14:38 P NO PRE-DELIVERY FINDINGS

 21 11/20/13 7:31 P NO PRE-DELIVERY FINDINGS

 21 11/20/13 13:39 P NO PRE-DELIVERY FINDINGS

 22 11/21/13 7:31 P NO PRE-DELIVERY FINDINGS

 22 11/21/13 13:34 P PUPS PRESENT IN NESTING BOX

 22 11/21/13 13:49 P NO SIGNIFICANT FINDINGS DURING PARTURITION

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY

Page 711 of 1107
 TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91644 F 0 PPM PARTURITION OBS 20 11/18/13 7:31 P NO PRE-DELIVERY FINDINGS

 20 11/18/13 15:27 P NO PRE-DELIVERY FINDINGS

 21 11/19/13 7:31 P NO PRE-DELIVERY FINDINGS

 21 11/19/13 13:33 P PUPS PRESENT IN NESTING BOX

 21 11/19/13 13:48 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 22 11/20/13 6:45 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91645 F 0 PPM PARTURITION OBS 20 11/20/13 7:31 P NO PRE-DELIVERY FINDINGS

 20 11/20/13 15:04 P NO PRE-DELIVERY FINDINGS

 21 11/21/13 7:31 P NO PRE-DELIVERY FINDINGS

 21 11/21/13 13:34 P NO PRE-DELIVERY FINDINGS

 22 11/22/13 7:30 P PUPS PRESENT IN NESTING BOX

 22 11/22/13 9:14 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91648 F 0 PPM PARTURITION OBS 20 11/17/13 7:31 P NO PRE-DELIVERY FINDINGS

 20 11/17/13 14:26 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 7:31 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 13:42 P NO PRE-DELIVERY FINDINGS

 22 11/19/13 7:31 P NO PRE-DELIVERY FINDINGS

 22 11/19/13 13:33 P PUPS PRESENT IN NESTING BOX

 22 11/19/13 13:53 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 23 11/20/13 7:00 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91653 F 0 PPM PARTURITION OBS 20 11/19/13 7:31 P NO PRE-DELIVERY FINDINGS

 20 11/19/13 14:39 P NO PRE-DELIVERY FINDINGS

 21 11/20/13 7:31 P NO PRE-DELIVERY FINDINGS

 21 11/20/13 13:39 P NO PRE-DELIVERY FINDINGS

 22 11/21/13 7:31 P PUPS PRESENT IN NESTING BOX

 22 11/21/13 8:26 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91660 F 0 PPM PARTURITION OBS 20 11/19/13 7:32 P NO PRE-DELIVERY FINDINGS

 20 11/19/13 14:39 P NO PRE-DELIVERY FINDINGS

 21 11/20/13 7:32 P NO PRE-DELIVERY FINDINGS

 21 11/20/13 13:39 P NO PRE-DELIVERY FINDINGS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY

Page 712 of 1107
 TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91660 F 0 PPM PARTURITION OBS 22 11/21/13 7:31 P NO PRE-DELIVERY FINDINGS

 22 11/21/13 13:35 P PUPS PRESENT IN NESTING BOX

 22 11/21/13 13:56 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 23 11/22/13 8:15 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91670 F 0 PPM PARTURITION OBS 20 11/20/13 7:32 P NO PRE-DELIVERY FINDINGS

 20 11/20/13 15:04 P NO PRE-DELIVERY FINDINGS

 21 11/21/13 7:31 P NO PRE-DELIVERY FINDINGS

 21 11/21/13 13:35 P NO PRE-DELIVERY FINDINGS

 22 11/22/13 7:31 P PUPS PRESENT IN NESTING BOX

 22 11/22/13 9:18 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91672 F 0 PPM PARTURITION OBS 20 11/20/13 7:32 P NO PRE-DELIVERY FINDINGS

 20 11/20/13 15:05 P NO PRE-DELIVERY FINDINGS

 21 11/21/13 7:32 P NO PRE-DELIVERY FINDINGS

 21 11/21/13 13:35 P NO PRE-DELIVERY FINDINGS

 22 11/22/13 7:31 P PUPS PRESENT IN NESTING BOX

 22 11/22/13 9:21 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91632 F 50 PPM PARTURITION OBS 20 11/21/13 7:32 P NO PRE-DELIVERY FINDINGS

 20 11/21/13 14:48 P NO PRE-DELIVERY FINDINGS

 21 11/22/13 7:31 P NO PRE-DELIVERY FINDINGS

 21 11/22/13 13:40 P NO PRE-DELIVERY FINDINGS

 22 11/23/13 7:30 P NO PRE-DELIVERY FINDINGS

 22 11/23/13 13:31 P PUPS PRESENT IN NESTING BOX

 22 11/23/13 13:33 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 23 11/24/13 7:46 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91640 F 50 PPM PARTURITION OBS 20 11/21/13 7:32 P NO PRE-DELIVERY FINDINGS

 20 11/21/13 14:48 P NO PRE-DELIVERY FINDINGS

 21 11/22/13 7:31 P NO PRE-DELIVERY FINDINGS

 21 11/22/13 13:40 P NO PRE-DELIVERY FINDINGS

 22 11/23/13 7:30 P NO PRE-DELIVERY FINDINGS

 22 11/23/13 13:31 P PUPS PRESENT IN NESTING BOX

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY

Page 713 of 1107
 TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91640 F 50 PPM PARTURITION OBS 22 11/23/13 13:35 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 23 11/24/13 7:50 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91642 F 50 PPM PARTURITION OBS 20 11/18/13 7:31 P NO PRE-DELIVERY FINDINGS

 20 11/18/13 15:27 P NO PRE-DELIVERY FINDINGS

 21 11/19/13 7:32 P NO PRE-DELIVERY FINDINGS

 21 11/19/13 13:34 P NO PRE-DELIVERY FINDINGS

 22 11/20/13 7:32 P NO PRE-DELIVERY FINDINGS

 22 11/20/13 13:40 P PUPS PRESENT IN NESTING BOX

 22 11/20/13 13:48 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 22 11/20/13 14:24 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91647 F 50 PPM PARTURITION OBS 20 11/20/13 7:32 P NO PRE-DELIVERY FINDINGS

 20 11/20/13 15:07 P NO PRE-DELIVERY FINDINGS

 21 11/21/13 7:32 P NO PRE-DELIVERY FINDINGS

 21 11/21/13 13:35 P NO PRE-DELIVERY FINDINGS

 22 11/22/13 7:32 P NO PRE-DELIVERY FINDINGS

 22 11/22/13 13:41 P PUPS PRESENT IN NESTING BOX

 22 11/22/13 13:47 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91651 F 50 PPM PARTURITION OBS 20 11/18/13 7:32 P NO PRE-DELIVERY FINDINGS

 20 11/18/13 15:27 P NO PRE-DELIVERY FINDINGS

 21 11/19/13 7:32 P NO PRE-DELIVERY FINDINGS

 21 11/19/13 13:34 P NO PRE-DELIVERY FINDINGS

 22 11/20/13 7:33 P NO PRE-DELIVERY FINDINGS

 22 11/20/13 13:39 P NO PRE-DELIVERY FINDINGS

 23 11/21/13 7:32 P PUPS PRESENT IN NESTING BOX

 23 11/21/13 8:30 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91659 F 50 PPM PARTURITION OBS 20 11/18/13 7:32 P NO PRE-DELIVERY FINDINGS

 20 11/18/13 15:28 P NO PRE-DELIVERY FINDINGS

 21 11/19/13 7:33 P NO PRE-DELIVERY FINDINGS

 21 11/19/13 13:34 P NO PRE-DELIVERY FINDINGS

 22 11/20/13 7:33 P NO PRE-DELIVERY FINDINGS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY

Page 714 of 1107
 TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91659 F 50 PPM PARTURITION OBS 22 11/20/13 13:40 P PUPS PRESENT IN NESTING BOX

 22 11/20/13 13:57 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91661 F 50 PPM PARTURITION OBS 20 11/17/13 7:31 P NO PRE-DELIVERY FINDINGS

 20 11/17/13 14:49 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 7:32 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 13:43 P NO PRE-DELIVERY FINDINGS

 22 11/19/13 7:33 P PUPS PRESENT IN NESTING BOX

 22 11/19/13 7:42 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91663 F 50 PPM PARTURITION OBS 20 11/19/13 7:33 P NO PRE-DELIVERY FINDINGS

 20 11/19/13 14:57 P NO PRE-DELIVERY FINDINGS

 21 11/20/13 7:33 P NO PRE-DELIVERY FINDINGS

 21 11/20/13 13:40 P NO PRE-DELIVERY FINDINGS

 22 11/21/13 7:32 P NO PRE-DELIVERY FINDINGS

 22 11/21/13 13:36 P PUPS PRESENT IN NESTING BOX

 22 11/21/13 13:57 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91669 F 50 PPM PARTURITION OBS 20 11/17/13 7:31 P NO PRE-DELIVERY FINDINGS

 20 11/17/13 14:50 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 7:32 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 13:43 P NO PRE-DELIVERY FINDINGS

 22 11/19/13 7:33 P NO PRE-DELIVERY FINDINGS

 22 11/19/13 13:35 P PUPS PRESENT IN NESTING BOX

 22 11/19/13 14:02 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91673 F 50 PPM PARTURITION OBS 20 11/20/13 7:33 P NO PRE-DELIVERY FINDINGS

 20 11/20/13 15:08 P NO PRE-DELIVERY FINDINGS

 21 11/21/13 7:33 P NO PRE-DELIVERY FINDINGS

 21 11/21/13 13:36 P NO PRE-DELIVERY FINDINGS

 22 11/22/13 7:32 P NO PRE-DELIVERY FINDINGS

 22 11/22/13 13:41 P PUPS PRESENT IN NESTING BOX

 22 11/22/13 13:58 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91683 F 50 PPM PARTURITION OBS 20 11/21/13 7:33 P NO PRE-DELIVERY FINDINGS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY

Page 715 of 1107
 TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91683 F 50 PPM PARTURITION OBS 20 11/21/13 14:47 P NO PRE-DELIVERY FINDINGS

 21 11/22/13 7:32 P NO PRE-DELIVERY FINDINGS

 21 11/22/13 13:41 P NO PRE-DELIVERY FINDINGS

 22 11/23/13 7:31 P NO PRE-DELIVERY FINDINGS

 22 11/23/13 13:31 P PUPS PRESENT IN NESTING BOX

 22 11/23/13 13:43 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 23 11/24/13 7:54 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91685 F 50 PPM PARTURITION OBS 20 11/17/13 7:31 P NO PRE-DELIVERY FINDINGS

 20 11/17/13 14:49 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 7:33 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 13:44 P NO PRE-DELIVERY FINDINGS

 22 11/19/13 7:34 P NO PRE-DELIVERY FINDINGS

 22 11/19/13 13:35 P PUPS PRESENT IN NESTING BOX

 22 11/19/13 14:09 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91620 F 100 PPM PARTURITION OBS 20 11/19/13 7:34 P NO PRE-DELIVERY FINDINGS

 20 11/19/13 14:55 P NO PRE-DELIVERY FINDINGS

 21 11/20/13 7:34 P NO PRE-DELIVERY FINDINGS

 21 11/20/13 13:41 P NO PRE-DELIVERY FINDINGS

 22 11/21/13 7:33 P NO PRE-DELIVERY FINDINGS

 22 11/21/13 13:36 P VAGINAL DISCHARGE/MATERIAL

 23 11/22/13 7:32 P PUPS PRESENT IN NESTING BOX

 23 11/22/13 9:27 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91628 F 100 PPM PARTURITION OBS 20 11/18/13 7:33 P NO PRE-DELIVERY FINDINGS

 20 11/18/13 15:28 P NO PRE-DELIVERY FINDINGS

 21 11/19/13 7:34 P NO PRE-DELIVERY FINDINGS

 21 11/19/13 13:35 P NO PRE-DELIVERY FINDINGS

 22 11/20/13 7:34 P NO PRE-DELIVERY FINDINGS

 22 11/20/13 13:41 P PUPS PRESENT IN NESTING BOX

 22 11/20/13 14:02 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91631 F 100 PPM PARTURITION OBS 20 11/18/13 7:34 P NO PRE-DELIVERY FINDINGS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY

Page 716 of 1107
 TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91631 F 100 PPM PARTURITION OBS 20 11/18/13 15:28 P NO PRE-DELIVERY FINDINGS

 21 11/19/13 7:35 P NO PRE-DELIVERY FINDINGS

 21 11/19/13 13:35 P NO PRE-DELIVERY FINDINGS

 22 11/20/13 7:34 P PUPS PRESENT IN NESTING BOX

 22 11/20/13 8:23 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91636 F 100 PPM PARTURITION OBS 20 11/19/13 7:35 P NO PRE-DELIVERY FINDINGS

 20 11/19/13 14:56 P NO PRE-DELIVERY FINDINGS

 21 11/20/13 7:34 P NO PRE-DELIVERY FINDINGS

 21 11/20/13 13:41 P NO PRE-DELIVERY FINDINGS

 22 11/21/13 7:33 P NO PRE-DELIVERY FINDINGS

 22 11/21/13 13:36 P PUPS PRESENT IN NESTING BOX

 22 11/21/13 13:41 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 23 11/22/13 8:19 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91649 F 100 PPM PARTURITION OBS 20 11/17/13 7:32 P NO PRE-DELIVERY FINDINGS

 20 11/17/13 14:54 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 7:34 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 13:44 P NO PRE-DELIVERY FINDINGS

 22 11/19/13 7:35 P NO PRE-DELIVERY FINDINGS

 22 11/19/13 13:36 P PUPS PRESENT IN NESTING BOX

 22 11/19/13 14:14 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91650 F 100 PPM PARTURITION OBS 20 11/17/13 7:32 P NO PRE-DELIVERY FINDINGS

 20 11/17/13 14:56 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 7:34 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 13:45 P NO PRE-DELIVERY FINDINGS

 22 11/19/13 7:35 P NO PRE-DELIVERY FINDINGS

 22 11/19/13 13:36 P PUPS PRESENT IN NESTING BOX

 22 11/19/13 14:22 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91656 F 100 PPM PARTURITION OBS 20 11/22/13 7:33 P NO PRE-DELIVERY FINDINGS

 20 11/22/13 14:36 P NO PRE-DELIVERY FINDINGS

 21 11/23/13 7:31 P NO PRE-DELIVERY FINDINGS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY

Page 717 of 1107
 TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91656 F 100 PPM PARTURITION OBS 21 11/23/13 13:31 P NO PRE-DELIVERY FINDINGS

 22 11/24/13 7:30 P NO PRE-DELIVERY FINDINGS

 22 11/24/13 13:31 P PUPS PRESENT IN NESTING BOX

 22 11/24/13 13:35 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91671 F 100 PPM PARTURITION OBS 20 11/21/13 7:33 P NO PRE-DELIVERY FINDINGS

 20 11/21/13 14:54 P NO PRE-DELIVERY FINDINGS

 21 11/22/13 7:33 P NO PRE-DELIVERY FINDINGS

 21 11/22/13 13:41 P NO PRE-DELIVERY FINDINGS

 22 11/23/13 7:31 P NO PRE-DELIVERY FINDINGS

 22 11/23/13 13:32 P VAGINAL DISCHARGE/MATERIAL

 23 11/24/13 7:30 P PUPS PRESENT IN NESTING BOX

 23 11/24/13 7:57 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91675 F 100 PPM PARTURITION OBS 20 11/17/13 7:32 P NO PRE-DELIVERY FINDINGS

 20 11/17/13 14:53 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 7:34 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 13:45 P NO PRE-DELIVERY FINDINGS

 22 11/19/13 7:36 P NO PRE-DELIVERY FINDINGS

 22 11/19/13 13:37 P NO PRE-DELIVERY FINDINGS

 23 11/20/13 7:34 P PUPS PRESENT IN NESTING BOX

 23 11/20/13 8:31 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91677 F 100 PPM PARTURITION OBS 20 11/18/13 7:34 P NO PRE-DELIVERY FINDINGS

 20 11/18/13 15:28 P NO PRE-DELIVERY FINDINGS

 21 11/19/13 7:36 P NO PRE-DELIVERY FINDINGS

 21 11/19/13 13:37 P NO PRE-DELIVERY FINDINGS

 22 11/20/13 7:35 P NO PRE-DELIVERY FINDINGS

 22 11/20/13 13:42 P NO PRE-DELIVERY FINDINGS

 23 11/21/13 7:33 P NO PRE-DELIVERY FINDINGS

 23 11/21/13 13:37 P PUPS PRESENT IN NESTING BOX

 23 11/21/13 13:46 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91679 F 100 PPM PARTURITION OBS 20 11/17/13 7:32 P NO PRE-DELIVERY FINDINGS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY

Page 718 of 1107
 TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91679 F 100 PPM PARTURITION OBS 20 11/17/13 14:53 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 7:35 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 13:46 P NO PRE-DELIVERY FINDINGS

 22 11/19/13 7:36 P NO PRE-DELIVERY FINDINGS

 22 11/19/13 13:37 P PUPS PRESENT IN NESTING BOX

 22 11/19/13 14:27 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91684 F 100 PPM PARTURITION OBS 20 11/18/13 7:35 P NO PRE-DELIVERY FINDINGS

 20 11/18/13 15:29 P NO PRE-DELIVERY FINDINGS

 21 11/19/13 7:36 P NO PRE-DELIVERY FINDINGS

 21 11/19/13 13:37 P NO PRE-DELIVERY FINDINGS

 22 11/20/13 7:35 P NO PRE-DELIVERY FINDINGS

 22 11/20/13 13:42 P PUPS PRESENT IN NESTING BOX

 22 11/20/13 14:14 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 23 11/21/13 8:18 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91622 F 175 PPM PARTURITION OBS 20 11/17/13 7:32 P NO PRE-DELIVERY FINDINGS

 20 11/17/13 15:00 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 7:35 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 13:46 P VAGINAL DISCHARGE/MATERIAL

 22 11/19/13 7:37 P NO PRE-DELIVERY FINDINGS

 22 11/19/13 13:38 P PUPS PRESENT IN NESTING BOX

 22 11/19/13 14:23 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 23 11/20/13 7:10 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91623 F 175 PPM PARTURITION OBS - 11/17/13 7:32 P NO PRE-DELIVERY FINDINGS

 - 11/17/13 14:57 P NO PRE-DELIVERY FINDINGS

 - 11/18/13 7:35 P NO PRE-DELIVERY FINDINGS

 - 11/18/13 15:29 P NO PRE-DELIVERY FINDINGS

 - 11/19/13 7:37 P NO PRE-DELIVERY FINDINGS

 - 11/19/13 14:53 P NO PRE-DELIVERY FINDINGS

 - 11/20/13 7:35 P NO PRE-DELIVERY FINDINGS

 - 11/20/13 15:10 P NO PRE-DELIVERY FINDINGS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY

Page 719 of 1107
 TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91623 F 175 PPM PARTURITION OBS - 11/21/13 7:34 P NO PRE-DELIVERY FINDINGS

 - 11/21/13 14:49 P NO PRE-DELIVERY FINDINGS

 - 11/22/13 7:33 P NO PRE-DELIVERY FINDINGS

 - 11/22/13 14:36 P NO PRE-DELIVERY FINDINGS

 - 11/23/13 7:31 P NO PRE-DELIVERY FINDINGS

 - 11/23/13 14:30 P NO PRE-DELIVERY FINDINGS

 - 11/24/13 7:31 P NO PRE-DELIVERY FINDINGS

 - 11/24/13 14:38 P NO PRE-DELIVERY FINDINGS

 - 11/25/13 7:30 P NO PRE-DELIVERY FINDINGS

 - 11/25/13 14:39 P NO PRE-DELIVERY FINDINGS

 - 11/26/13 7:31 P NO PRE-DELIVERY FINDINGS

 - 11/26/13 14:46 P NO PRE-DELIVERY FINDINGS

 - 11/27/13 7:30 P NO PRE-DELIVERY FINDINGS

 - 11/27/13 14:20 P NO PRE-DELIVERY FINDINGS

 - 11/28/13 7:30 P NO PRE-DELIVERY FINDINGS

 - 11/28/13 14:16 P NO PRE-DELIVERY FINDINGS

 - 11/29/13 7:30 P NO PRE-DELIVERY FINDINGS

 - 11/29/13 14:12 P NO PRE-DELIVERY FINDINGS

 - 11/30/13 7:31 P NO PRE-DELIVERY FINDINGS

 - 11/30/13 14:03 P NO PRE-DELIVERY FINDINGS

 - 12/01/13 7:31 P NO PRE-DELIVERY FINDINGS

 - 12/01/13 14:02 P NO PRE-DELIVERY FINDINGS

 - 12/02/13 7:32 P NO PRE-DELIVERY FINDINGS

 - 12/02/13 14:23 P NO PRE-DELIVERY FINDINGS

 - 12/03/13 7:30 P NO PRE-DELIVERY FINDINGS

 - 12/03/13 14:25 P NO PRE-DELIVERY FINDINGS

 - 12/04/13 7:30 P NO PRE-DELIVERY FINDINGS

 - 12/04/13 14:41 P NO PRE-DELIVERY FINDINGS *

 - 12/05/13 8:15 P NO PRE-DELIVERY FINDINGS *

 91626 F 175 PPM PARTURITION OBS 20 11/20/13 7:35 P NO PRE-DELIVERY FINDINGS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY

 * - LATE COMPUTER ENTRY OBSERVATIONS FOR ABOVE DATES

Page 720 of 1107
 TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 11

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91626 F 175 PPM PARTURITION OBS 20 11/20/13 15:11 P NO PRE-DELIVERY FINDINGS

 21 11/21/13 7:34 P NO PRE-DELIVERY FINDINGS

 21 11/21/13 13:37 P NO PRE-DELIVERY FINDINGS

 22 11/22/13 7:33 P NO PRE-DELIVERY FINDINGS

 22 11/22/13 13:42 P PUPS PRESENT IN NESTING BOX

 22 11/22/13 14:06 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91643 F 175 PPM PARTURITION OBS 20 11/23/13 7:31 P NO PRE-DELIVERY FINDINGS

 20 11/23/13 14:30 P NO PRE-DELIVERY FINDINGS

 21 11/24/13 7:31 P NO PRE-DELIVERY FINDINGS

 21 11/24/13 13:32 P NO PRE-DELIVERY FINDINGS

 22 11/25/13 7:30 P NO PRE-DELIVERY FINDINGS

 22 11/25/13 13:33 P PUPS PRESENT IN NESTING BOX

 22 11/25/13 13:33 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 23 11/26/13 7:55 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91654 F 175 PPM PARTURITION OBS 20 11/22/13 7:33 P NO PRE-DELIVERY FINDINGS

 20 11/22/13 14:36 P NO PRE-DELIVERY FINDINGS

 21 11/23/13 7:32 P NO PRE-DELIVERY FINDINGS

 21 11/23/13 13:32 P NO PRE-DELIVERY FINDINGS

 22 11/24/13 7:31 P NO PRE-DELIVERY FINDINGS

 22 11/24/13 13:32 P NO PRE-DELIVERY FINDINGS

 23 11/25/13 7:31 P NO PRE-DELIVERY FINDINGS

 23 11/25/13 13:33 P PUPS PRESENT IN NESTING BOX

 23 11/25/13 13:42 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91657 F 175 PPM PARTURITION OBS 20 11/28/13 7:30 P NO PRE-DELIVERY FINDINGS

 20 11/28/13 14:17 P NO PRE-DELIVERY FINDINGS

 21 11/29/13 7:30 P NO PRE-DELIVERY FINDINGS

 21 11/29/13 14:12 P NO PRE-DELIVERY FINDINGS

 22 11/30/13 7:31 P NO PRE-DELIVERY FINDINGS

 22 11/30/13 13:37 P PUPS PRESENT IN NESTING BOX

 22 11/30/13 14:04 P NO SIGNIFICANT FINDINGS DURING PARTURITION

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY

Page 721 of 1107
 TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 12

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91657 F 175 PPM PARTURITION OBS 23 12/01/13 6:29 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91662 F 175 PPM PARTURITION OBS 20 11/19/13 7:37 P NO PRE-DELIVERY FINDINGS

 20 11/19/13 14:53 P NO PRE-DELIVERY FINDINGS

 21 11/20/13 7:35 P NO PRE-DELIVERY FINDINGS

 21 11/20/13 13:42 P NO PRE-DELIVERY FINDINGS

 22 11/21/13 7:34 P NO PRE-DELIVERY FINDINGS

 22 11/21/13 13:37 P NO PRE-DELIVERY FINDINGS

 23 11/22/13 7:34 P PUPS PRESENT IN NESTING BOX

 23 11/22/13 9:32 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91666 F 175 PPM PARTURITION OBS 20 11/17/13 7:32 P NO PRE-DELIVERY FINDINGS

 20 11/17/13 14:57 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 7:35 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 13:47 P NO PRE-DELIVERY FINDINGS

 22 11/19/13 7:37 P NO PRE-DELIVERY FINDINGS

 22 11/19/13 13:38 P NO PRE-DELIVERY FINDINGS

 23 11/20/13 7:36 P PUPS PRESENT IN NESTING BOX

 23 11/20/13 8:36 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91676 F 175 PPM PARTURITION OBS 20 11/18/13 7:36 P NO PRE-DELIVERY FINDINGS

 20 11/18/13 15:30 P NO PRE-DELIVERY FINDINGS

 21 11/19/13 7:38 P NO PRE-DELIVERY FINDINGS

 21 11/19/13 13:38 P NO PRE-DELIVERY FINDINGS

 22 11/20/13 7:36 P NO PRE-DELIVERY FINDINGS

 22 11/20/13 13:43 P VAGINAL DISCHARGE/MATERIAL

 23 11/21/13 7:34 P PUPS PRESENT IN NESTING BOX

 23 11/21/13 8:35 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91678 F 175 PPM PARTURITION OBS 20 11/17/13 7:32 P NO PRE-DELIVERY FINDINGS

 20 11/17/13 15:00 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 7:36 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 13:47 P NO PRE-DELIVERY FINDINGS

 22 11/19/13 7:38 P NO PRE-DELIVERY FINDINGS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY

Page 722 of 1107
 TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 13

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91678 F 175 PPM PARTURITION OBS 22 11/19/13 13:39 P NO PRE-DELIVERY FINDINGS

 23 11/20/13 7:36 P PUPS PRESENT IN NESTING BOX

 23 11/20/13 8:46 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91681 F 175 PPM PARTURITION OBS 20 11/26/13 7:31 P NO PRE-DELIVERY FINDINGS

 20 11/26/13 14:46 P NO PRE-DELIVERY FINDINGS

 21 11/27/13 7:30 P NO PRE-DELIVERY FINDINGS

 21 11/27/13 14:00 P NO PRE-DELIVERY FINDINGS

 22 11/28/13 7:30 P NO PRE-DELIVERY FINDINGS

 22 11/28/13 14:24 P NO PRE-DELIVERY FINDINGS

 23 11/29/13 7:30 P PUPS PRESENT IN NESTING BOX

 23 11/29/13 7:38 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91682 F 175 PPM PARTURITION OBS 20 11/19/13 7:38 P NO PRE-DELIVERY FINDINGS

 20 11/19/13 14:53 P NO PRE-DELIVERY FINDINGS

 21 11/20/13 7:36 P NO PRE-DELIVERY FINDINGS

 21 11/20/13 13:43 P NO PRE-DELIVERY FINDINGS

 22 11/21/13 7:34 P NO PRE-DELIVERY FINDINGS

 22 11/21/13 13:37 P NO PRE-DELIVERY FINDINGS

 23 11/22/13 7:34 P NO PRE-DELIVERY FINDINGS

 23 11/22/13 13:42 P PUPS PRESENT IN NESTING BOX

 23 11/22/13 14:11 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 24 11/23/13 7:50 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91624 F 10000 PPM PARTURITION OBS 20 11/19/13 7:39 P NO PRE-DELIVERY FINDINGS

 20 11/19/13 14:36 P NO PRE-DELIVERY FINDINGS

 21 11/20/13 7:37 P NO PRE-DELIVERY FINDINGS

 21 11/20/13 13:43 P NO PRE-DELIVERY FINDINGS

 22 11/21/13 7:35 P NO PRE-DELIVERY FINDINGS

 22 11/21/13 13:38 P PUPS PRESENT IN NESTING BOX

 22 11/21/13 13:49 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91625 F 10000 PPM PARTURITION OBS 20 11/19/13 7:39 P NO PRE-DELIVERY FINDINGS

 20 11/19/13 14:35 P NO PRE-DELIVERY FINDINGS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY

Page 723 of 1107
 TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 14

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91625 F 10000 PPM PARTURITION OBS 21 11/20/13 7:37 P NO PRE-DELIVERY FINDINGS

 21 11/20/13 13:44 P NO PRE-DELIVERY FINDINGS

 22 11/21/13 7:35 P NO PRE-DELIVERY FINDINGS

 22 11/21/13 13:38 P NO PRE-DELIVERY FINDINGS

 23 11/22/13 7:34 P PUPS PRESENT IN NESTING BOX

 23 11/22/13 9:41 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91627 F 10000 PPM PARTURITION OBS 20 11/17/13 7:33 P NO PRE-DELIVERY FINDINGS

 20 11/17/13 14:34 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 7:36 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 13:48 P NO PRE-DELIVERY FINDINGS

 22 11/19/13 7:39 P NO PRE-DELIVERY FINDINGS

 22 11/19/13 13:39 P PUPS PRESENT IN NESTING BOX

 22 11/19/13 13:50 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91634 F 10000 PPM PARTURITION OBS 20 11/20/13 7:37 P NO PRE-DELIVERY FINDINGS

 20 11/20/13 15:05 P NO PRE-DELIVERY FINDINGS

 21 11/21/13 7:35 P NO PRE-DELIVERY FINDINGS

 21 11/21/13 13:39 P NO PRE-DELIVERY FINDINGS

 22 11/22/13 7:34 P NO PRE-DELIVERY FINDINGS

 22 11/22/13 13:42 P PUPS PRESENT IN NESTING BOX

 22 11/22/13 14:22 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91635 F 10000 PPM PARTURITION OBS 20 11/17/13 7:33 P NO PRE-DELIVERY FINDINGS

 20 11/17/13 14:32 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 7:36 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 13:48 P NO PRE-DELIVERY FINDINGS

 22 11/19/13 7:39 P NO PRE-DELIVERY FINDINGS

 22 11/19/13 13:40 P PUPS PRESENT IN NESTING BOX

 22 11/19/13 13:56 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91638 F 10000 PPM PARTURITION OBS 20 11/19/13 7:40 P NO PRE-DELIVERY FINDINGS

 20 11/19/13 14:36 P NO PRE-DELIVERY FINDINGS

 21 11/20/13 7:37 P NO PRE-DELIVERY FINDINGS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY

Page 724 of 1107
 TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 15

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91638 F 10000 PPM PARTURITION OBS 21 11/20/13 13:44 P NO PRE-DELIVERY FINDINGS

 22 11/21/13 7:35 P NO PRE-DELIVERY FINDINGS

 22 11/21/13 13:39 P PUPS PRESENT IN NESTING BOX

 22 11/21/13 13:53 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91652 F 10000 PPM PARTURITION OBS 20 11/17/13 7:33 P NO PRE-DELIVERY FINDINGS

 20 11/17/13 14:34 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 7:36 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 13:49 P NO PRE-DELIVERY FINDINGS

 22 11/19/13 7:40 P NO PRE-DELIVERY FINDINGS

 22 11/19/13 13:39 P PUPS PRESENT IN NESTING BOX

 22 11/19/13 14:13 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91655 F 10000 PPM PARTURITION OBS 20 11/17/13 7:33 P NO PRE-DELIVERY FINDINGS

 20 11/17/13 14:31 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 7:37 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 13:49 P NO PRE-DELIVERY FINDINGS

 22 11/19/13 7:40 P NO PRE-DELIVERY FINDINGS

 22 11/19/13 13:39 P PUPS PRESENT IN NESTING BOX

 22 11/19/13 14:18 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91658 F 10000 PPM PARTURITION OBS 20 11/18/13 7:37 P NO PRE-DELIVERY FINDINGS

 20 11/18/13 15:30 P NO PRE-DELIVERY FINDINGS

 21 11/19/13 7:40 P NO PRE-DELIVERY FINDINGS

 21 11/19/13 13:40 P NO PRE-DELIVERY FINDINGS

 22 11/20/13 7:37 P PUPS PRESENT IN NESTING BOX

 22 11/20/13 8:54 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91667 F 10000 PPM PARTURITION OBS 20 11/18/13 7:37 P NO PRE-DELIVERY FINDINGS

 20 11/18/13 15:31 P NO PRE-DELIVERY FINDINGS

 21 11/19/13 7:41 P NO PRE-DELIVERY FINDINGS

 21 11/19/13 13:40 P NO PRE-DELIVERY FINDINGS

 22 11/20/13 7:37 P PUPS PRESENT IN NESTING BOX

 22 11/20/13 8:59 P NO SIGNIFICANT FINDINGS DURING PARTURITION

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY

Page 725 of 1107
 TABLE A36 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 16

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL DAM OBSERVATIONS DURING PARTURITION

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY GD DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91668 F 10000 PPM PARTURITION OBS 20 11/18/13 7:37 P NO PRE-DELIVERY FINDINGS

 20 11/18/13 15:31 P NO PRE-DELIVERY FINDINGS

 21 11/19/13 7:41 P NO PRE-DELIVERY FINDINGS

 21 11/19/13 13:40 P NO PRE-DELIVERY FINDINGS

 22 11/20/13 7:38 P NO PRE-DELIVERY FINDINGS

 22 11/20/13 13:44 P PUPS PRESENT IN NESTING BOX

 22 11/20/13 14:20 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 23 11/21/13 8:22 P NO SIGNIFICANT FINDINGS DURING PARTURITION

 91680 F 10000 PPM PARTURITION OBS 20 11/17/13 7:33 P NO PRE-DELIVERY FINDINGS

 20 11/17/13 14:35 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 7:37 P NO PRE-DELIVERY FINDINGS

 21 11/18/13 13:49 P NO PRE-DELIVERY FINDINGS

 22 11/19/13 7:41 P PUPS PRESENT IN NESTING BOX

 22 11/19/13 7:54 P NO SIGNIFICANT FINDINGS DURING PARTURITION

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT GD = GESTATIONAL DAY

 PPOCRDv1.05

 01/07/2014

Page 726 of 1107
 TABLE A37 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL SPERM MOTILITY AND CONCENTRATION

 0 PPM

 SPERM

 PROGRESSIVE CAUDA EPID, LT TESTIS, LT PRODUCTION

 ANIMAL MOTILITY MOTILITY WEIGHT CONC WEIGHT CONC RATE

-----------------------------------------------------------------------------------------------------------------------------------

 91555 86. 70. 0.2512 769.8 1.52 98.9 16.2

 91560 72. 48. 0.2944 390.3 1.69 98.3 16.1

 91562 84. 72. 0.2560 775.0 1.56 125.4 20.6

 91563 86. 66. 0.2791 467.2 1.65 113.1 18.5

 91564 82. 61. 0.2773 677.4 1.64 85.3 14.0

 91567 78. 63. 0.2696 819.7 1.59 97.3 15.9

 91579 72. 55. 0.2849 842.2 1.66 75.0 12.3

 91586 71. 57. 0.2795 524.5 1.61 102.5 16.8

 91591 70. 49. 0.2775 857.6 1.70 106.0 17.4

 91592 78. 60. 0.3003 529.3 1.76 92.1 15.1

 91609 75. 59. 0.3171 782.7 1.78 113.3 18.6

 91615 68. 53. 0.3024 528.2 1.64 96.9 15.9

 MEAN 77. 59. 0.2824 663.7 1.65 100.3 16.4

 S.D. 6.5 7.6 0.01902 165.40 0.076 13.34 2.19

 S.E. 1.9 2.2 0.00549 47.75 0.022 3.85 0.63

 N 12 12 12 12 12 12 12

UNITS: MOTILITY (%), WEIGHT (GRAMS), CONCENTRATION (MILLIONS/GRAM), PRODUCTION RATE (MILLIONS/GRAM/DAY)

Page 727 of 1107
 TABLE A37 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL SPERM MOTILITY AND CONCENTRATION

 50 PPM

 SPERM

 PROGRESSIVE CAUDA EPID, LT TESTIS, LT PRODUCTION

 ANIMAL MOTILITY MOTILITY WEIGHT CONC WEIGHT CONC RATE

-----------------------------------------------------------------------------------------------------------------------------------

 91556 79. 62. 0.2826 547.4 1.67 103.9 17.0

 91559 83. 69. 0.2970 760.6 1.79 88.8 14.6

 91561 68. 52. 0.3222 792.6 1.61 84.2 13.8

 91566 69. 59. 0.2596 428.5 1.73 93.7 15.4

 91576 79. 64. 0.2934 795.7 1.67 82.9 13.6

 91582 84. 71. 0.3067 494.8 1.90 66.7 10.9

 91585 77. 62. 0.2929 684.1 1.72 92.1 15.1

 91589 74. 61. 0.2590 557.5 1.53 105.9 17.4

 91593 73. 55. 0.2649 897.8 1.47 130.3 21.4

 91594 68. 50. 0.3126 370.0 1.62 148.4 24.3

 91595 78. 64. 0.3439 607.8 1.70 89.3 14.6

 91602 73. 56. 0.3050 693.5 1.81 114.5 18.8

 MEAN 75. 60. 0.2950 635.8 1.69 100.0 16.4

 S.D. 5.5 6.4 0.02576 161.90 0.119 22.38 3.67

 S.E. 1.6 1.8 0.00744 46.74 0.034 6.46 1.06

 N 12 12 12 12 12 12 12

UNITS: MOTILITY (%), WEIGHT (GRAMS), CONCENTRATION (MILLIONS/GRAM), PRODUCTION RATE (MILLIONS/GRAM/DAY)

Page 728 of 1107
 TABLE A37 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL SPERM MOTILITY AND CONCENTRATION

 100 PPM

 SPERM

 PROGRESSIVE CAUDA EPID, LT TESTIS, LT PRODUCTION

 ANIMAL MOTILITY MOTILITY WEIGHT CONC WEIGHT CONC RATE

-----------------------------------------------------------------------------------------------------------------------------------

 91569 56. 45. 0.2398 442.4 1.48 109.0 17.9

 91573 76. 58. 0.2993 848.2 1.86 97.4 16.0

 91577 83. 69. 0.2611 710.3 1.57 85.4 14.0

 91581 77. 58. 0.3040 508.9 1.59 100.0 16.4

 91583 68. 58. 0.2789 784.8 1.74 111.1 18.2

 91588 71. 58. 0.2997 467.0 1.85 79.6 13.1

 91590 75. 60. 0.2844 661.3 1.55 131.8 21.6

 91598 70. 47. 0.2715 599.8 1.55 105.0 17.2

 91599 77. 64. 0.2566 496.6 1.52 93.0 15.3

 91608 77. 61. 0.2618 776.6 1.76 88.7 14.5

 91611 73. 61. 0.3093 711.1 1.68 120.6 19.8

 91616 87. 72. 0.2749 764.6 1.81 120.5 19.7

 MEAN 74. 59. 0.2784 647.6 1.66 103.5 17.0

 S.D. 7.8 7.7 0.02161 140.33 0.136 15.80 2.59

 S.E. 2.2 2.2 0.00624 40.51 0.039 4.56 0.75

 N 12 12 12 12 12 12 12

UNITS: MOTILITY (%), WEIGHT (GRAMS), CONCENTRATION (MILLIONS/GRAM), PRODUCTION RATE (MILLIONS/GRAM/DAY)

Page 729 of 1107
 TABLE A37 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL SPERM MOTILITY AND CONCENTRATION

 175 PPM

 SPERM

 PROGRESSIVE CAUDA EPID, LT TESTIS, LT PRODUCTION

 ANIMAL MOTILITY MOTILITY WEIGHT CONC WEIGHT CONC RATE

-----------------------------------------------------------------------------------------------------------------------------------

 91565 89. 69. 0.2525 542.6 1.41 115.5 18.9

 91568 71. 54. 0.2921 428.7 1.60 127.1 20.8

 91570 83. 65. 0.2583 459.2 1.68 117.5 19.3

 91572 82. 65. 0.2723 776.8 1.65 91.5 15.0

 91580 79. 60. 0.2866 560.3 1.72 89.5 14.7

 91584 76. 55. 0.2757 816.8 1.74 100.1 16.4

 91587 77. 66. 0.3195 657.9 1.87 135.0 22.1

 91597 79. 55. 0.2668 1006.7 1.75 110.7 18.1

 91601 84. 66. 0.2826 628.2 1.59 102.9 16.9

 91607 86. 71. 0.2889 418.2 1.69 111.3 18.2

 91613 78. 65. 0.2233 353.0 1.56 79.8 13.1

 91614 78. 62. 0.3280 503.1 1.65 85.3 14.0

 MEAN 80. 63. 0.2789 596.0 1.66 105.5 17.3

 S.D. 4.9 5.6 0.02832 191.92 0.115 17.04 2.79

 S.E. 1.4 1.6 0.00817 55.40 0.033 4.92 0.81

 N 12 12 12 12 12 12 12

UNITS: MOTILITY (%), WEIGHT (GRAMS), CONCENTRATION (MILLIONS/GRAM), PRODUCTION RATE (MILLIONS/GRAM/DAY)

Page 730 of 1107
 TABLE A37 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL SPERM MOTILITY AND CONCENTRATION

 10000 PPM

 SPERM

 PROGRESSIVE CAUDA EPID, LT TESTIS, LT PRODUCTION

 ANIMAL MOTILITY MOTILITY WEIGHT CONC WEIGHT CONC RATE

-----------------------------------------------------------------------------------------------------------------------------------

 91554 79. 61. 0.2980 755.7 1.52 94.5 15.5

 91557 80. 64. 0.2711 733.7 1.88 91.0 14.9

 91558 76. 55. 0.2771 573.7 1.58 120.6 19.8

 91571 82. 67. 0.2693 391.2 1.50 77.1 12.6

 91575 81. 66. 0.2104 556.7 1.55 94.1 15.4

 91600 67. 57. 0.3179 1075.2 1.72 112.9 18.5

 91603 81. 70. 0.2831 735.5 1.73 95.1 15.6

 91604 49. 35. 0.2876 577.7 1.71 83.6 13.7

 91605 84. 65. 0.3019 226.9 1.86 98.6 16.2

 91612 85. 70. 0.3086 662.0 1.86 108.6 17.8

 91618 77. 59. 0.2653 558.1 1.55 98.4 16.1

 91619 77. 61. 0.2584 684.2 1.62 100.9 16.5

 MEAN 77. 61. 0.2791 627.5 1.67 97.9 16.1

 S.D. 9.8 9.4 0.02835 207.96 0.140 12.00 1.97

 S.E. 2.8 2.7 0.00819 60.03 0.040 3.46 0.57

 N 12 12 12 12 12 12 12

UNITS: MOTILITY (%), WEIGHT (GRAMS), CONCENTRATION (MILLIONS/GRAM), PRODUCTION RATE (MILLIONS/GRAM/DAY)

 PDIVOSv4.30

 01/20/2014

Page 731 of 1107
 TABLE A38 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL SPERM MORPHOLOGY DIFFERENTIAL COUNTS [PERCENTAGE]

 MALE GROUP: 0 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 NORMAL HEAD HEAD MISSHAPEN MISSHAPEN FLAGELLAR

 HEAD/ ABSENT/ ABSENT/ HEAD/ HEAD/ DEFECTS/

 SEPARATED NORMAL ABNORMAL NORMAL ABNORMAL NORMAL

 ANIMAL NORMAL FLAGELLUM FLAGELLUM FLAGELLUM FLAGELLUM FLAGELLUM HEAD

-----------------------------------------------------------------------------------------------------------------------------------

 91555 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91560 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91562 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91563 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91564 97.5 1.5 1.0 0.0 0.0 0.0 0.0

 91567 99.0 0.0 1.0 0.0 0.0 0.0 0.0

 91579 94.0 5.0 1.0 0.0 0.0 0.0 0.0

 91586 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91591 99.0 1.0 0.0 0.0 0.0 0.0 0.0

 91592 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91609 99.5 0.5 0.0 0.0 0.0 0.0 0.0

 91615 99.5 0.0 0.5 0.0 0.0 0.0 0.0

-----------------------------------------------------------------------------------------------------------------------------------

 MEAN 99.0 0.7 0.3 0.0 0.0 0.0 0.0

 S.D. 1.75 1.45 0.45 0.00 0.00 0.00 0.00

 S.E. 0.51 0.42 0.13 0.00 0.00 0.00 0.00

 N 12 12 12 12 12 12 12

Page 732 of 1107
 TABLE A38 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL SPERM MORPHOLOGY DIFFERENTIAL COUNTS [PERCENTAGE]

 MALE GROUP: 50 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 NORMAL HEAD HEAD MISSHAPEN MISSHAPEN FLAGELLAR

 HEAD/ ABSENT/ ABSENT/ HEAD/ HEAD/ DEFECTS/

 SEPARATED NORMAL ABNORMAL NORMAL ABNORMAL NORMAL

 ANIMAL NORMAL FLAGELLUM FLAGELLUM FLAGELLUM FLAGELLUM FLAGELLUM HEAD

-----------------------------------------------------------------------------------------------------------------------------------

 91556 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91559 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91561 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91566 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91576 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91582 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91585 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91589 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91593 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91594 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91595 99.5 0.5 0.0 0.0 0.0 0.0 0.0

 91602 100.0 0.0 0.0 0.0 0.0 0.0 0.0

-----------------------------------------------------------------------------------------------------------------------------------

 MEAN 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 S.D. 0.14 0.14 0.00 0.00 0.00 0.00 0.00

 S.E. 0.04 0.04 0.00 0.00 0.00 0.00 0.00

 N 12 12 12 12 12 12 12

Page 733 of 1107
 TABLE A38 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL SPERM MORPHOLOGY DIFFERENTIAL COUNTS [PERCENTAGE]

 MALE GROUP: 100 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 NORMAL HEAD HEAD MISSHAPEN MISSHAPEN FLAGELLAR

 HEAD/ ABSENT/ ABSENT/ HEAD/ HEAD/ DEFECTS/

 SEPARATED NORMAL ABNORMAL NORMAL ABNORMAL NORMAL

 ANIMAL NORMAL FLAGELLUM FLAGELLUM FLAGELLUM FLAGELLUM FLAGELLUM HEAD

-----------------------------------------------------------------------------------------------------------------------------------

 91569 95.5 2.5 2.0 0.0 0.0 0.0 0.0

 91573 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91577 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91581 98.5 1.0 0.5 0.0 0.0 0.0 0.0

 91583 98.5 0.5 1.0 0.0 0.0 0.0 0.0

 91588 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91590 99.5 0.5 0.0 0.0 0.0 0.0 0.0

 91598 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91599 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91608 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91611 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91616 100.0 0.0 0.0 0.0 0.0 0.0 0.0

-----------------------------------------------------------------------------------------------------------------------------------

 MEAN 99.3 0.4 0.3 0.0 0.0 0.0 0.0

 S.D. 1.34 0.74 0.62 0.00 0.00 0.00 0.00

 S.E. 0.39 0.21 0.18 0.00 0.00 0.00 0.00

 N 12 12 12 12 12 12 12

Page 734 of 1107
 TABLE A38 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL SPERM MORPHOLOGY DIFFERENTIAL COUNTS [PERCENTAGE]

 MALE GROUP: 175 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 NORMAL HEAD HEAD MISSHAPEN MISSHAPEN FLAGELLAR

 HEAD/ ABSENT/ ABSENT/ HEAD/ HEAD/ DEFECTS/

 SEPARATED NORMAL ABNORMAL NORMAL ABNORMAL NORMAL

 ANIMAL NORMAL FLAGELLUM FLAGELLUM FLAGELLUM FLAGELLUM FLAGELLUM HEAD

-----------------------------------------------------------------------------------------------------------------------------------

 91565 99.5 0.0 0.5 0.0 0.0 0.0 0.0

 91568 99.5 0.0 0.5 0.0 0.0 0.0 0.0

 91570 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91572 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91580 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91584 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91587 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91597 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91601 99.5 0.0 0.5 0.0 0.0 0.0 0.0

 91607 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91613 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91614 100.0 0.0 0.0 0.0 0.0 0.0 0.0

-----------------------------------------------------------------------------------------------------------------------------------

 MEAN 99.9 0.0 0.1 0.0 0.0 0.0 0.0

 S.D. 0.23 0.00 0.23 0.00 0.00 0.00 0.00

 S.E. 0.07 0.00 0.07 0.00 0.00 0.00 0.00

 N 12 12 12 12 12 12 12

Page 735 of 1107
 TABLE A38 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL SPERM MORPHOLOGY DIFFERENTIAL COUNTS [PERCENTAGE]

 MALE GROUP: 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 NORMAL HEAD HEAD MISSHAPEN MISSHAPEN FLAGELLAR

 HEAD/ ABSENT/ ABSENT/ HEAD/ HEAD/ DEFECTS/

 SEPARATED NORMAL ABNORMAL NORMAL ABNORMAL NORMAL

 ANIMAL NORMAL FLAGELLUM FLAGELLUM FLAGELLUM FLAGELLUM FLAGELLUM HEAD

-----------------------------------------------------------------------------------------------------------------------------------

 91554 99.5 0.5 0.0 0.0 0.0 0.0 0.0

 91557 98.5 1.0 0.5 0.0 0.0 0.0 0.0

 91558 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91571 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91575 98.5 0.0 1.5 0.0 0.0 0.0 0.0

 91600 99.5 0.0 0.5 0.0 0.0 0.0 0.0

 91603 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91604 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91605 97.5 2.0 0.5 0.0 0.0 0.0 0.0

 91612 100.0 0.0 0.0 0.0 0.0 0.0 0.0

 91618 99.0 0.0 1.0 0.0 0.0 0.0 0.0

 91619 100.0 0.0 0.0 0.0 0.0 0.0 0.0

-----------------------------------------------------------------------------------------------------------------------------------

 MEAN 99.4 0.3 0.3 0.0 0.0 0.0 0.0

 S.D. 0.83 0.62 0.49 0.00 0.00 0.00 0.00

 S.E. 0.24 0.18 0.14 0.00 0.00 0.00 0.00

 N 12 12 12 12 12 12 12

 MANUALv1.0

 11/14/2013

 R:11/14/2013

Page 736 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91555 GROUP 1: 0 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 2.16 0.470 PAS STAIN EXAMINED

LIVER 14.72 3.200 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

KIDNEYS 3.45 0.750 PAS STAIN EXAMINED

SPLEEN 0.85 0.185 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

LUNGS 1.62 0.352 PAS STAIN EXAMINED

TESTIS, RT 1.50 0.326 NO SIGNIFICANT

TESTIS, LT 1.52 0.330 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

EPIDIDYMIS, LT 0.58 0.126 EYES HEART INTESTINE KIDNEYS

CAUDA EPID, LT 0.2512 0.055 LIVER LN, MESENTERIC LUNGS PANCREAS

PITUITARY 0.0178 0.004 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

EPIDIDYMIS, RT 0.59 0.128 SKIN SPLEEN STOMACH SEMINAL VESICLES

CAUDA EPID, RT 0.2510 0.055 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

FINAL BODY WT(G) 460. URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT LUNGS PITUITARY PROSTATE

 SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL

 EPIDIDYMIS, LT VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 737 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91560 GROUP 1: 0 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 2.23 0.487 PAS STAIN EXAMINED

LIVER 15.81 3.452 LUNGS MICRO: MINERALIZATION, VASCULAR 1

KIDNEYS 3.54 0.773 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

SPLEEN 0.87 0.190 PAS STAIN EXAMINED

LUNGS 1.88 0.410 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

TESTIS, RT 1.70 0.371 PAS STAIN EXAMINED

TESTIS, LT 1.69 0.369 NO SIGNIFICANT

EPIDIDYMIS, LT 0.60 0.131 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

CAUDA EPID, LT 0.2944 0.064 EYES HEART INTESTINE KIDNEYS

PITUITARY 0.0149 0.003 LIVER LN, MESENTERIC LUNGS PANCREAS

EPIDIDYMIS, RT 0.64 0.140 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

CAUDA EPID, RT 0.2717 0.059 SKIN SPLEEN STOMACH SEMINAL VESICLES

FINAL BODY WT(G) 458. TESTIS, RT THYMUS THYROID GLANDS TRACHEA

 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN

 SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT

 VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 738 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91562 GROUP 1: 0 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 2.05 0.476 PAS STAIN EXAMINED

LIVER 16.66 3.872 KIDNEYS GROSS: DILATED PELVIS 2

KIDNEYS 3.28 0.762 RIGHT

SPLEEN 0.82 0.191 ^==> KIDNEYS: DILATATION, PELVIS

LUNGS 1.40 0.325 KIDNEYS MICRO: DILATATION, PELVIS 2

TESTIS, RT 1.62 0.376 ONE KIDNEY EXAMINED

TESTIS, LT 1.56 0.363 CONGESTION 3

EPIDIDYMIS, LT 0.57 0.132 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

CAUDA EPID, LT 0.2560 0.059 PAS STAIN EXAMINED

PITUITARY 0.0133 0.003 URETERS MICRO: DILATATION 1

EPIDIDYMIS, RT 0.62 0.144 UNILATERAL; BOTH URETERS EXAMINED

CAUDA EPID, RT 0.2690 0.063 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

FINAL BODY WT(G) 430. PAS STAIN EXAMINED

 NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

 EYES HEART INTESTINE LIVER

 LN, MESENTERIC LUNGS PANCREAS PITUITARY

 PROSTATE SPINAL CORD SAL. GLAND MAND SKIN

 SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT

 VAS DEFERENS

 MICRO:EPIDIDYMIS, RT LUNGS PITUITARY PROSTATE

 SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL

 EPIDIDYMIS, LT VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 739 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91563 GROUP 1: 0 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 2.08 0.503 PAS STAIN EXAMINED

LIVER 14.49 3.503 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

KIDNEYS 3.32 0.803 PAS STAIN EXAMINED

SPLEEN 0.70 0.169 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

LUNGS 1.68 0.406 PAS STAIN EXAMINED

TESTIS, RT 1.67 0.404 NO SIGNIFICANT

TESTIS, LT 1.65 0.399 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

EPIDIDYMIS, LT 0.55 0.133 EYES HEART INTESTINE KIDNEYS

CAUDA EPID, LT 0.2791 0.067 LIVER LN, MESENTERIC LUNGS PANCREAS

PITUITARY 0.0142 0.003 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

EPIDIDYMIS, RT 0.64 0.155 SKIN SPLEEN STOMACH SEMINAL VESICLES

CAUDA EPID, RT 0.2878 0.070 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

FINAL BODY WT(G) 414. URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT LUNGS PITUITARY PROSTATE

 SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL

 EPIDIDYMIS, LT VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 740 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91564 GROUP 1: 0 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 2.10 0.495 PAS STAIN EXAMINED

LIVER 14.20 3.349 LUNGS MICRO: MINERALIZATION, VASCULAR 1

KIDNEYS 3.56 0.840 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

SPLEEN 0.66 0.156 PAS STAIN EXAMINED

LUNGS 1.65 0.389 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

TESTIS, RT 1.68 0.396 PAS STAIN EXAMINED

TESTIS, LT 1.64 0.387 NO SIGNIFICANT

EPIDIDYMIS, LT 0.56 0.132 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

CAUDA EPID, LT 0.2773 0.065 EYES HEART INTESTINE KIDNEYS

PITUITARY 0.0178 0.004 LIVER LN, MESENTERIC LUNGS PANCREAS

EPIDIDYMIS, RT 0.62 0.146 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

CAUDA EPID, RT 0.2677 0.063 SKIN SPLEEN STOMACH SEMINAL VESICLES

FINAL BODY WT(G) 424. TESTIS, RT THYMUS THYROID GLANDS TRACHEA

 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN

 SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT

 VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 741 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91567 GROUP 1: 0 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 1.86 0.452 PAS STAIN EXAMINED

LIVER 15.57 3.787 LUNGS MICRO: ATELECTASIS 3

KIDNEYS 3.23 0.786 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

SPLEEN 0.74 0.180 PAS STAIN EXAMINED

LUNGS 1.41 0.343 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

TESTIS, RT 1.59 0.387 PAS STAIN EXAMINED

TESTIS, LT 1.59 0.387 NO SIGNIFICANT

EPIDIDYMIS, LT 0.55 0.134 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

CAUDA EPID, LT 0.2696 0.066 EYES HEART INTESTINE KIDNEYS

PITUITARY 0.0102 0.002 LIVER LN, MESENTERIC LUNGS PANCREAS

EPIDIDYMIS, RT 0.62 0.151 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

CAUDA EPID, RT 0.2710 0.066 SKIN SPLEEN STOMACH SEMINAL VESICLES

FINAL BODY WT(G) 411. TESTIS, RT THYMUS THYROID GLANDS TRACHEA

 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN

 SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT

 VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 742 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91579 GROUP 1: 0 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 2.17 0.464 PAS STAIN EXAMINED

LIVER 17.75 3.793 LUNGS MICRO: MINERALIZATION, VASCULAR 1

KIDNEYS 3.26 0.697 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

SPLEEN 0.90 0.192 PAS STAIN EXAMINED

LUNGS 1.78 0.380 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

TESTIS, RT 1.66 0.355 PAS STAIN EXAMINED

TESTIS, LT 1.66 0.355 NO SIGNIFICANT

EPIDIDYMIS, LT 0.63 0.135 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

CAUDA EPID, LT 0.2849 0.061 EYES HEART INTESTINE KIDNEYS

PITUITARY 0.0179 0.004 LIVER LN, MESENTERIC LUNGS PANCREAS

EPIDIDYMIS, RT 0.61 0.130 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

CAUDA EPID, RT 0.2482 0.053 SKIN SPLEEN STOMACH SEMINAL VESICLES

FINAL BODY WT(G) 468. TESTIS, RT THYMUS THYROID GLANDS TRACHEA

 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN

 SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT

 VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 743 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91586 GROUP 1: 0 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 2.12 0.463 PAS STAIN EXAMINED

LIVER 16.47 3.594 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

KIDNEYS 3.42 0.746 PAS STAIN EXAMINED

SPLEEN 0.94 0.205 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

LUNGS 1.75 0.382 PAS STAIN EXAMINED

TESTIS, RT 1.63 0.356 NO SIGNIFICANT

TESTIS, LT 1.61 0.351 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

EPIDIDYMIS, LT 0.57 0.124 EYES HEART INTESTINE KIDNEYS

CAUDA EPID, LT 0.2795 0.061 LIVER LN, MESENTERIC LUNGS PANCREAS

PITUITARY 0.0227 0.005 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

EPIDIDYMIS, RT 0.67 0.146 SKIN SPLEEN STOMACH SEMINAL VESICLES

CAUDA EPID, RT 0.2952 0.064 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

FINAL BODY WT(G) 458. URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT LUNGS PITUITARY PROSTATE

 SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL

 EPIDIDYMIS, LT VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 744 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91591 GROUP 1: 0 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 2.11 0.463 PAS STAIN EXAMINED

LIVER 14.86 3.260 LUNGS MICRO: ATELECTASIS 3

KIDNEYS 3.35 0.735 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

SPLEEN 0.77 0.169 PAS STAIN EXAMINED

LUNGS 1.75 0.384 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

TESTIS, RT 1.69 0.371 PAS STAIN EXAMINED

TESTIS, LT 1.70 0.373 NO SIGNIFICANT

EPIDIDYMIS, LT 0.55 0.121 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

CAUDA EPID, LT 0.2775 0.061 EYES HEART INTESTINE KIDNEYS

PITUITARY 0.0136 0.003 LIVER LN, MESENTERIC LUNGS PANCREAS

EPIDIDYMIS, RT 0.60 0.132 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

CAUDA EPID, RT 0.2654 0.058 SKIN SPLEEN STOMACH SEMINAL VESICLES

FINAL BODY WT(G) 456. TESTIS, RT THYMUS THYROID GLANDS TRACHEA

 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN

 SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT

 VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 745 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91592 GROUP 1: 0 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 2.28 0.450 PAS STAIN EXAMINED

LIVER 17.30 3.412 LUNGS MICRO: MINERALIZATION, VASCULAR 1

KIDNEYS 3.44 0.679 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

SPLEEN 1.06 0.209 PAS STAIN EXAMINED

LUNGS 1.86 0.367 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

TESTIS, RT 1.79 0.353 PAS STAIN EXAMINED

TESTIS, LT 1.76 0.347 NO SIGNIFICANT

EPIDIDYMIS, LT 0.63 0.124 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

CAUDA EPID, LT 0.3003 0.059 EYES HEART INTESTINE KIDNEYS

PITUITARY 0.0148 0.003 LIVER LN, MESENTERIC LUNGS PANCREAS

EPIDIDYMIS, RT 0.67 0.132 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

CAUDA EPID, RT 0.2779 0.055 SKIN SPLEEN STOMACH SEMINAL VESICLES

FINAL BODY WT(G) 507. TESTIS, RT THYMUS THYROID GLANDS TRACHEA

 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN

 SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT

 VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 746 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 11

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91609 GROUP 1: 0 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 2.16 0.489 PAS STAIN EXAMINED

LIVER 15.38 3.480 LUNGS MICRO: MINERALIZATION, VASCULAR 1

KIDNEYS 3.52 0.796 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

SPLEEN 0.71 0.161 PAS STAIN EXAMINED

LUNGS 1.44 0.326 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

TESTIS, RT 1.86 0.421 PAS STAIN EXAMINED

TESTIS, LT 1.78 0.403 NO SIGNIFICANT

EPIDIDYMIS, LT 0.69 0.156 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

CAUDA EPID, LT 0.3171 0.072 EYES HEART INTESTINE KIDNEYS

PITUITARY 0.0145 0.003 LIVER LN, MESENTERIC LUNGS PANCREAS

EPIDIDYMIS, RT 0.72 0.163 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

CAUDA EPID, RT 0.3076 0.070 SKIN SPLEEN STOMACH SEMINAL VESICLES

FINAL BODY WT(G) 442. TESTIS, RT THYMUS THYROID GLANDS TRACHEA

 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN

 SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT

 VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 747 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 12

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91615 GROUP 1: 0 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 2.15 0.459 PAS STAIN EXAMINED

LIVER 16.54 3.530 LUNGS MICRO: ATELECTASIS 3

KIDNEYS 3.26 0.696 POST-TERMINAL

SPLEEN 0.79 0.169 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

LUNGS 1.68 0.359 PAS STAIN EXAMINED

TESTIS, RT 1.63 0.348 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

TESTIS, LT 1.64 0.350 PAS STAIN EXAMINED

EPIDIDYMIS, LT 0.60 0.128 NO SIGNIFICANT

CAUDA EPID, LT 0.3024 0.065 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

PITUITARY 0.0159 0.003 EYES HEART INTESTINE KIDNEYS

EPIDIDYMIS, RT 0.66 0.141 LIVER LN, MESENTERIC LUNGS PANCREAS

CAUDA EPID, RT 0.2768 0.059 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

FINAL BODY WT(G) 469. SKIN SPLEEN STOMACH SEMINAL VESICLES

 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN

 SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT

 VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 748 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 13

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91556 GROUP 2: 50 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT

BRAIN 1.94 0.434 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

LIVER 14.68 3.284 EYES HEART INTESTINE KIDNEYS

KIDNEYS 3.07 0.687 LIVER LN, MESENTERIC LUNGS PANCREAS

SPLEEN 0.67 0.150 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

LUNGS 1.57 0.351 SKIN SPLEEN STOMACH SEMINAL VESICLES

TESTIS, RT 1.68 0.376 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

TESTIS, LT 1.67 0.374 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

EPIDIDYMIS, LT 0.64 0.143 EPIDIDYMIS, LT VAS DEFERENS

CAUDA EPID, LT 0.2826 0.063

PITUITARY 0.0126 0.003

EPIDIDYMIS, RT 0.68 0.152

CAUDA EPID, RT 0.2840 0.064

FINAL BODY WT(G) 447.

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 749 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 14

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91559 GROUP 2: 50 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT

BRAIN 1.95 0.456 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

LIVER 16.22 3.790 EYES HEART INTESTINE KIDNEYS

KIDNEYS 3.46 0.808 LIVER LN, MESENTERIC LUNGS PANCREAS

SPLEEN 0.85 0.199 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

LUNGS 1.89 0.442 SKIN SPLEEN STOMACH SEMINAL VESICLES

TESTIS, RT 1.77 0.414 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

TESTIS, LT 1.79 0.418 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

EPIDIDYMIS, LT 0.59 0.138 EPIDIDYMIS, LT VAS DEFERENS

CAUDA EPID, LT 0.2970 0.069

PITUITARY 0.0143 0.003

EPIDIDYMIS, RT 0.62 0.145

CAUDA EPID, RT 0.2438 0.057

FINAL BODY WT(G) 428.

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 750 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 15

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91561 GROUP 2: 50 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT

BRAIN 2.09 0.459 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

LIVER 16.27 3.575 EYES HEART INTESTINE KIDNEYS

KIDNEYS 3.46 0.760 LIVER LN, MESENTERIC LUNGS PANCREAS

SPLEEN 0.86 0.189 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

LUNGS 1.80 0.396 SKIN SPLEEN STOMACH SEMINAL VESICLES

TESTIS, RT 1.68 0.369 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

TESTIS, LT 1.61 0.354 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

EPIDIDYMIS, LT 0.68 0.149 EPIDIDYMIS, LT VAS DEFERENS

CAUDA EPID, LT 0.3222 0.071

PITUITARY 0.0176 0.004

EPIDIDYMIS, RT 0.69 0.152

CAUDA EPID, RT 0.3183 0.070

FINAL BODY WT(G) 455.

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 751 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 16

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91566 GROUP 2: 50 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT

BRAIN 1.87 0.437 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

LIVER 14.61 3.411 EYES HEART INTESTINE KIDNEYS

KIDNEYS 3.24 0.756 LIVER LN, MESENTERIC LUNGS PANCREAS

SPLEEN 0.72 0.168 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

LUNGS 1.48 0.346 SKIN SPLEEN STOMACH SEMINAL VESICLES

TESTIS, RT 1.71 0.399 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

TESTIS, LT 1.73 0.404 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

EPIDIDYMIS, LT 0.61 0.142 EPIDIDYMIS, LT VAS DEFERENS

CAUDA EPID, LT 0.2596 0.061

PITUITARY 0.0120 0.003

EPIDIDYMIS, RT 0.67 0.156

CAUDA EPID, RT 0.2544 0.059

FINAL BODY WT(G) 428.

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 752 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 17

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91576 GROUP 2: 50 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT

BRAIN 2.09 0.506 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

LIVER 14.82 3.587 EYES HEART INTESTINE KIDNEYS

KIDNEYS 3.37 0.816 LIVER LN, MESENTERIC LUNGS PANCREAS

SPLEEN 0.79 0.191 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

LUNGS 1.42 0.344 SKIN SPLEEN STOMACH SEMINAL VESICLES

TESTIS, RT 1.66 0.402 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

TESTIS, LT 1.67 0.404 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

EPIDIDYMIS, LT 0.60 0.145 EPIDIDYMIS, LT VAS DEFERENS

CAUDA EPID, LT 0.2934 0.071

PITUITARY 0.0134 0.003

EPIDIDYMIS, RT 0.64 0.155

CAUDA EPID, RT 0.3055 0.074

FINAL BODY WT(G) 413.

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 753 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 18

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91582 GROUP 2: 50 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT

BRAIN 2.14 0.417 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

LIVER 18.93 3.690 EYES HEART INTESTINE KIDNEYS

KIDNEYS 3.94 0.768 LIVER LN, MESENTERIC LUNGS PANCREAS

SPLEEN 1.01 0.197 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

LUNGS 1.70 0.331 SKIN SPLEEN STOMACH SEMINAL VESICLES

TESTIS, RT 1.94 0.378 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

TESTIS, LT 1.90 0.370 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

EPIDIDYMIS, LT 0.64 0.125 EPIDIDYMIS, LT VAS DEFERENS

CAUDA EPID, LT 0.3067 0.060

PITUITARY 0.0162 0.003

EPIDIDYMIS, RT 0.70 0.136

CAUDA EPID, RT 0.2774 0.054

FINAL BODY WT(G) 513.

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 754 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 19

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91585 GROUP 2: 50 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT

BRAIN 2.04 0.408 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

LIVER 21.23 4.246 EYES HEART INTESTINE KIDNEYS

KIDNEYS 3.98 0.796 LIVER LN, MESENTERIC LUNGS PANCREAS

SPLEEN 1.04 0.208 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

LUNGS 1.79 0.358 SKIN SPLEEN STOMACH SEMINAL VESICLES

TESTIS, RT 1.67 0.334 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

TESTIS, LT 1.72 0.344 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

EPIDIDYMIS, LT 0.67 0.134 EPIDIDYMIS, LT VAS DEFERENS

CAUDA EPID, LT 0.2929 0.059

PITUITARY 0.0174 0.003

EPIDIDYMIS, RT 0.69 0.138

CAUDA EPID, RT 0.2850 0.057

FINAL BODY WT(G) 500.

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 755 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 20

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91589 GROUP 2: 50 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT

BRAIN 2.02 0.486 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

LIVER 13.44 3.232 EYES HEART INTESTINE KIDNEYS

KIDNEYS 2.92 0.702 LIVER LN, MESENTERIC LUNGS PANCREAS

SPLEEN 0.69 0.166 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

LUNGS 1.72 0.414 SKIN SPLEEN STOMACH SEMINAL VESICLES

TESTIS, RT 1.60 0.385 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

TESTIS, LT 1.53 0.368 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

EPIDIDYMIS, LT 0.54 0.130 EPIDIDYMIS, LT VAS DEFERENS

CAUDA EPID, LT 0.2590 0.062

PITUITARY 0.0129 0.003

EPIDIDYMIS, RT 0.57 0.137

CAUDA EPID, RT 0.2568 0.062

FINAL BODY WT(G) 416.

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 756 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 21

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91593 GROUP 2: 50 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT

BRAIN 2.17 0.476 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

LIVER 16.35 3.589 EYES HEART INTESTINE KIDNEYS

KIDNEYS 3.49 0.766 LIVER LN, MESENTERIC LUNGS PANCREAS

SPLEEN 0.96 0.211 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

LUNGS 1.63 0.358 SKIN SPLEEN STOMACH SEMINAL VESICLES

TESTIS, RT 1.41 0.309 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

TESTIS, LT 1.47 0.323 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

EPIDIDYMIS, LT 0.55 0.121 EPIDIDYMIS, LT VAS DEFERENS

CAUDA EPID, LT 0.2649 0.058

PITUITARY 0.0165 0.004

EPIDIDYMIS, RT 0.61 0.134

CAUDA EPID, RT 0.2732 0.060

FINAL BODY WT(G) 456.

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 757 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 22

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91594 GROUP 2: 50 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT

BRAIN 2.07 0.458 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

LIVER 16.00 3.543 EYES HEART INTESTINE KIDNEYS

KIDNEYS 2.98 0.660 LIVER LN, MESENTERIC LUNGS PANCREAS

SPLEEN 0.74 0.164 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

LUNGS 2.02 0.447 SKIN SPLEEN STOMACH SEMINAL VESICLES

TESTIS, RT 1.67 0.370 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

TESTIS, LT 1.62 0.359 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

EPIDIDYMIS, LT 0.58 0.128 EPIDIDYMIS, LT VAS DEFERENS

CAUDA EPID, LT 0.3126 0.069

PITUITARY 0.0153 0.003

EPIDIDYMIS, RT 0.60 0.133

CAUDA EPID, RT 0.2789 0.062

FINAL BODY WT(G) 452.

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 758 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 23

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91595 GROUP 2: 50 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. KIDNEYS GROSS: DILATED PELVIS 2

BRAIN 2.19 0.458 RIGHT

LIVER 17.08 3.573 ^==> KIDNEYS: DILATATION, PELVIS

KIDNEYS 3.04 0.636 KIDNEYS MICRO: DILATATION, PELVIS 2

SPLEEN 0.92 0.192 ONE KIDNEY EXAMINED

LUNGS 1.82 0.381 URETERS MICRO: DILATATION 1

TESTIS, RT 1.66 0.347 ONE OF PAIR PRESENT

TESTIS, LT 1.70 0.356 NO SIGNIFICANT

EPIDIDYMIS, LT 0.67 0.140 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

CAUDA EPID, LT 0.3439 0.072 EYES HEART INTESTINE LIVER

PITUITARY 0.0146 0.003 LN, MESENTERIC LUNGS PANCREAS PITUITARY

EPIDIDYMIS, RT 0.71 0.149 PROSTATE SPINAL CORD SAL. GLAND MAND SKIN

CAUDA EPID, RT 0.3060 0.064 SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT

FINAL BODY WT(G) 478. THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT

 VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 759 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 24

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91602 GROUP 2: 50 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT

BRAIN 1.89 0.392 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

LIVER 16.87 3.500 EYES HEART INTESTINE KIDNEYS

KIDNEYS 3.65 0.757 LIVER LN, MESENTERIC LUNGS PANCREAS

SPLEEN 0.79 0.164 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

LUNGS 1.70 0.353 SKIN SPLEEN STOMACH SEMINAL VESICLES

TESTIS, RT 1.80 0.373 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

TESTIS, LT 1.81 0.376 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

EPIDIDYMIS, LT 0.62 0.129 EPIDIDYMIS, LT VAS DEFERENS

CAUDA EPID, LT 0.3050 0.063

PITUITARY 0.0120 0.002

EPIDIDYMIS, RT 0.65 0.135

CAUDA EPID, RT 0.3072 0.064

FINAL BODY WT(G) 482.

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 760 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 25

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91569 GROUP 3: 100 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT

BRAIN 2.06 0.479 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

LIVER 14.10 3.279 EYES HEART INTESTINE KIDNEYS

KIDNEYS 2.81 0.653 LIVER LN, MESENTERIC LUNGS PANCREAS

SPLEEN 0.89 0.207 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

LUNGS 1.60 0.372 SKIN SPLEEN STOMACH SEMINAL VESICLES

TESTIS, RT 1.61 0.374 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

TESTIS, LT 1.48 0.344 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

EPIDIDYMIS, LT 0.54 0.126 EPIDIDYMIS, LT VAS DEFERENS

CAUDA EPID, LT 0.2398 0.056

PITUITARY 0.0103 0.002

EPIDIDYMIS, RT 0.56 0.130

CAUDA EPID, RT 0.2163 0.050

FINAL BODY WT(G) 430.

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 761 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 26

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91573 GROUP 3: 100 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT MICRO: NOT EXAMINED PER WIL SOP P

BRAIN 2.16 0.522 SKIN GROSS: MATTING, RED P

LIVER 15.39 3.718 OCULAR, BILATERAL

KIDNEYS 3.27 0.790 ^==> GENERAL COMMENT: NOT EXAMINED PER WIL SOP

SPLEEN 0.75 0.181 TEETH GROSS: MALALIGNED P

LUNGS 1.47 0.355 UPPER INCISOR, BILATERAL; CEO MALALIGNED

TESTIS, RT 1.86 0.449 ^==> GENERAL COMMENT: NOT EXAMINED PER WIL SOP

TESTIS, LT 1.86 0.449 NO SIGNIFICANT

EPIDIDYMIS, LT 0.65 0.157 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

CAUDA EPID, LT 0.2993 0.072 EYES HEART INTESTINE KIDNEYS

PITUITARY 0.0134 0.003 LIVER LN, MESENTERIC LUNGS PANCREAS

EPIDIDYMIS, RT 0.73 0.176 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

CAUDA EPID, RT 0.3138 0.076 SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT

FINAL BODY WT(G) 414. THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT

 VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 762 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 27

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91577 GROUP 3: 100 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT

BRAIN 2.02 0.494 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

LIVER 14.70 3.594 EYES HEART INTESTINE KIDNEYS

KIDNEYS 3.19 0.780 LIVER LN, MESENTERIC LUNGS PANCREAS

SPLEEN 0.68 0.166 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

LUNGS 1.84 0.450 SKIN SPLEEN STOMACH SEMINAL VESICLES

TESTIS, RT 1.55 0.379 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

TESTIS, LT 1.57 0.384 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

EPIDIDYMIS, LT 0.53 0.130 EPIDIDYMIS, LT VAS DEFERENS

CAUDA EPID, LT 0.2611 0.064

PITUITARY 0.0105 0.003

EPIDIDYMIS, RT 0.57 0.139

CAUDA EPID, RT 0.2454 0.060

FINAL BODY WT(G) 409.

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 763 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 28

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91581 GROUP 3: 100 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT

BRAIN 2.07 0.471 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

LIVER 15.67 3.569 EYES HEART INTESTINE KIDNEYS

KIDNEYS 3.32 0.756 LIVER LN, MESENTERIC LUNGS PANCREAS

SPLEEN 0.72 0.164 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

LUNGS 1.78 0.405 SKIN SPLEEN STOMACH SEMINAL VESICLES

TESTIS, RT 1.63 0.371 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

TESTIS, LT 1.59 0.362 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

EPIDIDYMIS, LT 0.59 0.134 EPIDIDYMIS, LT VAS DEFERENS

CAUDA EPID, LT 0.3040 0.069

PITUITARY 0.0125 0.003

EPIDIDYMIS, RT 0.64 0.146

CAUDA EPID, RT 0.2767 0.063

FINAL BODY WT(G) 439.

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 764 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 29

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91583 GROUP 3: 100 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT

BRAIN 2.02 0.497 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

LIVER 14.21 3.495 EYES HEART INTESTINE KIDNEYS

KIDNEYS 2.97 0.730 LIVER LN, MESENTERIC LUNGS PANCREAS

SPLEEN 0.75 0.184 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

LUNGS 1.71 0.421 SKIN SPLEEN STOMACH SEMINAL VESICLES

TESTIS, RT 1.75 0.430 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

TESTIS, LT 1.74 0.428 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

EPIDIDYMIS, LT 0.61 0.150 EPIDIDYMIS, LT VAS DEFERENS

CAUDA EPID, LT 0.2789 0.069

PITUITARY 0.0119 0.003

EPIDIDYMIS, RT 0.66 0.162

CAUDA EPID, RT 0.2743 0.067

FINAL BODY WT(G) 407.

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 765 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 30

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91588 GROUP 3: 100 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT

BRAIN 1.99 0.439 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

LIVER 17.58 3.881 EYES HEART INTESTINE KIDNEYS

KIDNEYS 3.60 0.795 LIVER LN, MESENTERIC LUNGS PANCREAS

SPLEEN 0.71 0.157 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

LUNGS 1.66 0.366 SKIN SPLEEN STOMACH SEMINAL VESICLES

TESTIS, RT 1.85 0.408 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

TESTIS, LT 1.85 0.408 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

EPIDIDYMIS, LT 0.63 0.139 EPIDIDYMIS, LT VAS DEFERENS

CAUDA EPID, LT 0.2997 0.066

PITUITARY 0.0125 0.003

EPIDIDYMIS, RT 0.64 0.141

CAUDA EPID, RT 0.3015 0.067

FINAL BODY WT(G) 453.

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 766 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 31

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91590 GROUP 3: 100 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT

BRAIN 2.18 0.487 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

LIVER 15.06 3.365 EYES HEART INTESTINE KIDNEYS

KIDNEYS 3.15 0.704 LIVER LN, MESENTERIC LUNGS PANCREAS

SPLEEN 0.80 0.179 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

LUNGS 1.61 0.360 SKIN SPLEEN STOMACH SEMINAL VESICLES

TESTIS, RT 1.54 0.344 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

TESTIS, LT 1.55 0.346 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

EPIDIDYMIS, LT 0.57 0.127 EPIDIDYMIS, LT VAS DEFERENS

CAUDA EPID, LT 0.2844 0.064

PITUITARY 0.0151 0.003

EPIDIDYMIS, RT 0.63 0.141

CAUDA EPID, RT 0.2792 0.062

FINAL BODY WT(G) 448.

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 767 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 32

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91598 GROUP 3: 100 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT

BRAIN 1.97 0.478 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

LIVER 14.00 3.398 EYES HEART INTESTINE KIDNEYS

KIDNEYS 3.45 0.837 LIVER LN, MESENTERIC LUNGS PANCREAS

SPLEEN 0.74 0.180 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

LUNGS 1.74 0.422 SKIN SPLEEN STOMACH SEMINAL VESICLES

TESTIS, RT 1.54 0.374 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

TESTIS, LT 1.55 0.376 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

EPIDIDYMIS, LT 0.57 0.138 EPIDIDYMIS, LT VAS DEFERENS

CAUDA EPID, LT 0.2715 0.066

PITUITARY 0.0136 0.003

EPIDIDYMIS, RT 0.59 0.143

CAUDA EPID, RT 0.2539 0.062

FINAL BODY WT(G) 412.

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 768 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 33

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91599 GROUP 3: 100 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT

BRAIN 2.02 0.486 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

LIVER 15.92 3.829 EYES HEART INTESTINE KIDNEYS

KIDNEYS 3.13 0.753 LIVER LN, MESENTERIC LUNGS PANCREAS

SPLEEN 0.77 0.185 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

LUNGS 1.64 0.394 SKIN SPLEEN STOMACH SEMINAL VESICLES

TESTIS, RT 1.52 0.366 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

TESTIS, LT 1.52 0.366 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

EPIDIDYMIS, LT 0.56 0.135 EPIDIDYMIS, LT VAS DEFERENS

CAUDA EPID, LT 0.2566 0.062

PITUITARY 0.0123 0.003

EPIDIDYMIS, RT 0.60 0.144

CAUDA EPID, RT 0.2632 0.063

FINAL BODY WT(G) 416.

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 769 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 34

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91608 GROUP 3: 100 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT

BRAIN 2.03 0.456 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

LIVER 14.49 3.256 EYES HEART INTESTINE KIDNEYS

KIDNEYS 3.35 0.753 LIVER LN, MESENTERIC LUNGS PANCREAS

SPLEEN 0.79 0.178 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

LUNGS 1.80 0.404 SKIN SPLEEN STOMACH SEMINAL VESICLES

TESTIS, RT 1.75 0.393 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

TESTIS, LT 1.76 0.396 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

EPIDIDYMIS, LT 0.57 0.128 EPIDIDYMIS, LT VAS DEFERENS

CAUDA EPID, LT 0.2618 0.059

PITUITARY 0.0117 0.003

EPIDIDYMIS, RT 0.64 0.144

CAUDA EPID, RT 0.2603 0.058

FINAL BODY WT(G) 445.

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 770 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 35

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91611 GROUP 3: 100 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT

BRAIN 1.95 0.442 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

LIVER 15.63 3.547 EYES HEART INTESTINE KIDNEYS

KIDNEYS 3.35 0.760 LIVER LN, MESENTERIC LUNGS PANCREAS

SPLEEN 0.74 0.168 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

LUNGS 1.67 0.379 SKIN SPLEEN STOMACH SEMINAL VESICLES

TESTIS, RT 1.70 0.386 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

TESTIS, LT 1.68 0.381 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

EPIDIDYMIS, LT 0.66 0.150 EPIDIDYMIS, LT VAS DEFERENS

CAUDA EPID, LT 0.3093 0.070

PITUITARY 0.0130 0.003

EPIDIDYMIS, RT 0.66 0.150

CAUDA EPID, RT 0.2551 0.058

FINAL BODY WT(G) 441.

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 771 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 36

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91616 GROUP 3: 100 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANT

BRAIN 2.07 0.456 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

LIVER 16.80 3.700 EYES HEART INTESTINE KIDNEYS

KIDNEYS 3.33 0.733 LIVER LN, MESENTERIC LUNGS PANCREAS

SPLEEN 0.78 0.172 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

LUNGS 1.74 0.383 SKIN SPLEEN STOMACH SEMINAL VESICLES

TESTIS, RT 1.76 0.388 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

TESTIS, LT 1.81 0.399 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

EPIDIDYMIS, LT 0.58 0.128 EPIDIDYMIS, LT VAS DEFERENS

CAUDA EPID, LT 0.2749 0.061

PITUITARY 0.0141 0.003

EPIDIDYMIS, RT 0.66 0.145

CAUDA EPID, RT 0.2745 0.060

FINAL BODY WT(G) 454.

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 772 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 37

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91565 GROUP 4: 175 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 2.06 0.505 PAS STAIN EXAMINED

LIVER 14.18 3.475 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

KIDNEYS 2.94 0.721 PAS STAIN EXAMINED

SPLEEN 0.68 0.167 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

LUNGS 1.67 0.409 PAS STAIN EXAMINED

TESTIS, RT 1.47 0.360 NO SIGNIFICANT

TESTIS, LT 1.41 0.346 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

EPIDIDYMIS, LT 0.53 0.130 EYES HEART INTESTINE KIDNEYS

CAUDA EPID, LT 0.2525 0.062 LIVER LN, MESENTERIC LUNGS PANCREAS

PITUITARY 0.0106 0.003 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

EPIDIDYMIS, RT 0.59 0.145 SKIN SPLEEN STOMACH SEMINAL VESICLES

CAUDA EPID, RT 0.2524 0.062 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

FINAL BODY WT(G) 408. URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT LUNGS PITUITARY PROSTATE

 SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL

 EPIDIDYMIS, LT VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 773 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 38

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91568 GROUP 4: 175 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 1.99 0.454 PAS STAIN EXAMINED

LIVER 16.32 3.719 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

KIDNEYS 3.81 0.868 PAS STAIN EXAMINED

SPLEEN 0.68 0.155 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

LUNGS 1.70 0.387 PAS STAIN EXAMINED

TESTIS, RT 1.63 0.371 NO SIGNIFICANT

TESTIS, LT 1.60 0.365 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

EPIDIDYMIS, LT 0.62 0.141 EYES HEART INTESTINE KIDNEYS

CAUDA EPID, LT 0.2921 0.067 LIVER LN, MESENTERIC LUNGS PANCREAS

PITUITARY 0.0140 0.003 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

EPIDIDYMIS, RT 0.62 0.141 SKIN SPLEEN STOMACH SEMINAL VESICLES

CAUDA EPID, RT 0.2490 0.057 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

FINAL BODY WT(G) 439. URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT LUNGS PITUITARY PROSTATE

 SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL

 EPIDIDYMIS, LT VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 774 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 39

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91570 GROUP 4: 175 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 1.91 0.450 PAS STAIN EXAMINED

LIVER 14.48 3.409 KIDNEYS GROSS: AREA(S), DEPRESSED P

KIDNEYS 3.20 0.753 FEW, PINPOINT, IN CORTEX, BILATERAL

SPLEEN 0.86 0.202 ^==> KIDNEYS: INDENTATION, CAPSULAR

LUNGS 1.67 0.393 KIDNEYS MICRO: INDENTATION, CAPSULAR 2

TESTIS, RT 1.64 0.386 FOCAL

TESTIS, LT 1.68 0.395 LUNGS MICRO: ATELECTASIS 3

EPIDIDYMIS, LT 0.61 0.144 PROSTATE MICRO: INFLAMMATION, SUBACUTE 1

CAUDA EPID, LT 0.2583 0.061 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

PITUITARY 0.0124 0.003 PAS STAIN EXAMINED

EPIDIDYMIS, RT 0.64 0.151 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

CAUDA EPID, RT 0.2848 0.067 PAS STAIN EXAMINED

FINAL BODY WT(G) 425. NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

 EYES HEART INTESTINE LIVER

 LN, MESENTERIC LUNGS PANCREAS PITUITARY

 PROSTATE SPINAL CORD SAL. GLAND MAND SKIN

 SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT

 VAS DEFERENS

 MICRO:EPIDIDYMIS, RT PITUITARY SPLEEN SEMINAL VESICLES

 TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 775 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 40

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91572 GROUP 4: 175 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 2.09 0.489 PAS STAIN EXAMINED

LIVER 16.20 3.794 LUNGS MICRO: ATELECTASIS 3

KIDNEYS 3.26 0.763 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

SPLEEN 0.83 0.194 PAS STAIN EXAMINED

LUNGS 1.91 0.447 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

TESTIS, RT 1.71 0.400 PAS STAIN EXAMINED

TESTIS, LT 1.65 0.386 NO SIGNIFICANT

EPIDIDYMIS, LT 0.60 0.141 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

CAUDA EPID, LT 0.2723 0.064 EYES HEART INTESTINE KIDNEYS

PITUITARY 0.0121 0.003 LIVER LN, MESENTERIC LUNGS PANCREAS

EPIDIDYMIS, RT 0.63 0.148 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

CAUDA EPID, RT 0.2798 0.066 SKIN SPLEEN STOMACH SEMINAL VESICLES

FINAL BODY WT(G) 427. TESTIS, RT THYMUS THYROID GLANDS TRACHEA

 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN

 SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT

 VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 776 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 41

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91580 GROUP 4: 175 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 2.00 0.483 PAS STAIN EXAMINED

LIVER 14.26 3.444 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

KIDNEYS 3.32 0.802 PAS STAIN EXAMINED

SPLEEN 0.60 0.145 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

LUNGS 1.87 0.452 PAS STAIN EXAMINED

TESTIS, RT 1.71 0.413 NO SIGNIFICANT

TESTIS, LT 1.72 0.415 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

EPIDIDYMIS, LT 0.58 0.140 EYES HEART INTESTINE KIDNEYS

CAUDA EPID, LT 0.2866 0.069 LIVER LN, MESENTERIC LUNGS PANCREAS

PITUITARY 0.0126 0.003 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

EPIDIDYMIS, RT 0.56 0.135 SKIN SPLEEN STOMACH SEMINAL VESICLES

CAUDA EPID, RT 0.2404 0.058 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

FINAL BODY WT(G) 414. URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT LUNGS PITUITARY PROSTATE

 SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL

 EPIDIDYMIS, LT VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 777 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 42

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91584 GROUP 4: 175 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 2.02 0.473 PAS STAIN EXAMINED

LIVER 15.90 3.726 LUNGS MICRO: INFLAMMATION, SUBACUTE 1

KIDNEYS 3.19 0.748 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

SPLEEN 0.73 0.171 PAS STAIN EXAMINED

LUNGS 1.73 0.405 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

TESTIS, RT 1.74 0.408 PAS STAIN EXAMINED

TESTIS, LT 1.74 0.408 NO SIGNIFICANT

EPIDIDYMIS, LT 0.66 0.155 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

CAUDA EPID, LT 0.2757 0.065 EYES HEART INTESTINE KIDNEYS

PITUITARY 0.0138 0.003 LIVER LN, MESENTERIC LUNGS PANCREAS

EPIDIDYMIS, RT 0.62 0.145 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

CAUDA EPID, RT 0.2533 0.059 SKIN SPLEEN STOMACH SEMINAL VESICLES

FINAL BODY WT(G) 427. TESTIS, RT THYMUS THYROID GLANDS TRACHEA

 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN

 SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT

 VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 778 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 43

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91587 GROUP 4: 175 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 2.03 0.430 PAS STAIN EXAMINED

LIVER 17.64 3.737 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

KIDNEYS 3.65 0.773 PAS STAIN EXAMINED

SPLEEN 0.99 0.210 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

LUNGS 2.01 0.426 PAS STAIN EXAMINED

TESTIS, RT 1.90 0.403 NO SIGNIFICANT

TESTIS, LT 1.87 0.396 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

EPIDIDYMIS, LT 0.66 0.140 EYES HEART INTESTINE KIDNEYS

CAUDA EPID, LT 0.3195 0.068 LIVER LN, MESENTERIC LUNGS PANCREAS

PITUITARY 0.0135 0.003 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

EPIDIDYMIS, RT 0.66 0.140 SKIN SPLEEN STOMACH SEMINAL VESICLES

CAUDA EPID, RT 0.2723 0.058 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

FINAL BODY WT(G) 472. URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT LUNGS PITUITARY PROSTATE

 SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL

 EPIDIDYMIS, LT VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 779 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 44

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91597 GROUP 4: 175 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 1.91 0.449 PAS STAIN EXAMINED

LIVER 14.18 3.336 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

KIDNEYS 3.31 0.779 PAS STAIN EXAMINED

SPLEEN 0.77 0.181 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

LUNGS 2.01 0.473 PAS STAIN EXAMINED

TESTIS, RT 1.74 0.409 NO SIGNIFICANT

TESTIS, LT 1.75 0.412 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

EPIDIDYMIS, LT 0.59 0.139 EYES HEART INTESTINE KIDNEYS

CAUDA EPID, LT 0.2668 0.063 LIVER LN, MESENTERIC LUNGS PANCREAS

PITUITARY 0.0113 0.003 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

EPIDIDYMIS, RT 0.66 0.155 SKIN SPLEEN STOMACH SEMINAL VESICLES

CAUDA EPID, RT 0.2745 0.065 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

FINAL BODY WT(G) 425. URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT LUNGS PITUITARY PROSTATE

 SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL

 EPIDIDYMIS, LT VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 780 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 45

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91601 GROUP 4: 175 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 2.04 0.475 PAS STAIN EXAMINED

LIVER 15.22 3.540 LUNGS MICRO: MINERALIZATION, VASCULAR 1

KIDNEYS 3.32 0.772 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

SPLEEN 0.84 0.195 PAS STAIN EXAMINED

LUNGS 1.61 0.375 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

TESTIS, RT 1.62 0.377 PAS STAIN EXAMINED

TESTIS, LT 1.59 0.370 NO SIGNIFICANT

EPIDIDYMIS, LT 0.60 0.140 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

CAUDA EPID, LT 0.2826 0.066 EYES HEART INTESTINE KIDNEYS

PITUITARY 0.0119 0.003 LIVER LN, MESENTERIC LUNGS PANCREAS

EPIDIDYMIS, RT 0.62 0.144 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

CAUDA EPID, RT 0.2693 0.063 SKIN SPLEEN STOMACH SEMINAL VESICLES

FINAL BODY WT(G) 430. TESTIS, RT THYMUS THYROID GLANDS TRACHEA

 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN

 SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT

 VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 781 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 46

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91607 GROUP 4: 175 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 2.17 0.464 PAS STAIN EXAMINED

LIVER 16.16 3.452 SPLEEN GROSS: AREA(S), WHITE P

KIDNEYS 3.16 0.675 MULTIPLE, 1 TO 6 MM IN DIAMETER

SPLEEN 0.86 0.184 ^==> SPLEEN: FIBROSIS, CAPSULAR

LUNGS 1.85 0.395 SPLEEN MICRO: INFLAMMATION, CHRONIC 2

TESTIS, RT 1.79 0.382 FOCAL WITHIN RED PULP ADJACENT TO CAPSULE

TESTIS, LT 1.69 0.361 FIBROSIS, CAPSULAR 2

EPIDIDYMIS, LT 0.62 0.132 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

CAUDA EPID, LT 0.2889 0.062 PAS STAIN EXAMINED

PITUITARY 0.0132 0.003 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

EPIDIDYMIS, RT 0.71 0.152 PAS STAIN EXAMINED

CAUDA EPID, RT 0.2990 0.064 NO SIGNIFICANT

FINAL BODY WT(G) 468. CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

 EYES HEART INTESTINE KIDNEYS

 LIVER LN, MESENTERIC LUNGS PANCREAS

 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

 SKIN STOMACH SEMINAL VESICLES TESTIS, RT

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT

 VAS DEFERENS

 MICRO:EPIDIDYMIS, RT LUNGS PITUITARY PROSTATE

 SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT

 VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 782 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 47

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91613 GROUP 4: 175 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 1.99 0.441 PAS STAIN EXAMINED

LIVER 15.45 3.426 LUNGS MICRO: MINERALIZATION, VASCULAR 2

KIDNEYS 3.22 0.714 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

SPLEEN 0.77 0.171 PAS STAIN EXAMINED

LUNGS 2.01 0.446 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

TESTIS, RT 1.56 0.346 PAS STAIN EXAMINED

TESTIS, LT 1.56 0.346 NO SIGNIFICANT

EPIDIDYMIS, LT 0.56 0.124 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

CAUDA EPID, LT 0.2233 0.050 EYES HEART INTESTINE KIDNEYS

PITUITARY 0.0144 0.003 LIVER LN, MESENTERIC LUNGS PANCREAS

EPIDIDYMIS, RT 0.61 0.135 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

CAUDA EPID, RT 0.2292 0.051 SKIN SPLEEN STOMACH SEMINAL VESICLES

FINAL BODY WT(G) 451. TESTIS, RT THYMUS THYROID GLANDS TRACHEA

 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN

 SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT

 VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 783 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 48

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91614 GROUP 4: 175 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 1.97 0.425 PAS STAIN EXAMINED

LIVER 16.89 3.640 PITUITARY MICRO: NO SIGNIFICANT CHANGES OBSERVED

KIDNEYS 3.74 0.806 PARS DISTALIS ONLY

SPLEEN 0.67 0.144 PROSTATE MICRO: INFLAMMATION, SUBACUTE 2

LUNGS 1.57 0.338 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

TESTIS, RT 1.71 0.369 PAS STAIN EXAMINED

TESTIS, LT 1.65 0.356 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

EPIDIDYMIS, LT 0.68 0.147 PAS STAIN EXAMINED

CAUDA EPID, LT 0.3280 0.071 NO SIGNIFICANT

PITUITARY 0.0128 0.003 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

EPIDIDYMIS, RT 0.71 0.153 EYES HEART INTESTINE KIDNEYS

CAUDA EPID, RT 0.3102 0.067 LIVER LN, MESENTERIC LUNGS PANCREAS

FINAL BODY WT(G) 464. PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

 SKIN SPLEEN STOMACH SEMINAL VESICLES

 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT LUNGS PITUITARY SPLEEN

 SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT

 VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 784 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 49

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91554 GROUP 5: 10000 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 1.97 0.477 PAS STAIN EXAMINED

LIVER 12.74 3.083 LUNGS MICRO: ATELECTASIS 2

KIDNEYS 2.51 0.607 HEMORRHAGE 2

SPLEEN 0.74 0.179 PER-ACUTE

LUNGS 1.53 0.370 PROSTATE MICRO: NO SIGNIFICANT CHANGES OBSERVED

TESTIS, RT 1.62 0.392 MILD INTERSTITIAL EDEMA

TESTIS, LT 1.52 0.368 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

EPIDIDYMIS, LT 0.63 0.152 PAS STAIN EXAMINED; MILD INTERSTITIAL EDEMA

CAUDA EPID, LT 0.2980 0.072 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

PITUITARY 0.0130 0.003 PAS STAIN EXAMINED

EPIDIDYMIS, RT 0.57 0.138 LN, MANDIBULAR GROSS: ENLARGED P

CAUDA EPID, RT 0.2265 0.055 BILATERAL

FINAL BODY WT(G) 413. ^==> LN, MANDIBULAR: HYPERPLASIA, LYMPHOID

 LN, MANDIBULAR MICRO: HYPERPLASIA, LYMPHOID 3

 BILATERAL, PARACORTICAL MOSTLY

 NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

 EYES HEART INTESTINE KIDNEYS

 LIVER LN, MESENTERIC LUNGS PANCREAS

 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

 SKIN SPLEEN STOMACH SEMINAL VESICLES

 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN

Page 785 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 50

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91554 GROUP 5: 10000 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

 SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT

 VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 786 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 51

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91557 GROUP 5: 10000 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 2.15 0.469 PAS STAIN EXAMINED

LIVER 14.88 3.245 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

KIDNEYS 3.30 0.720 PAS STAIN EXAMINED

SPLEEN 0.95 0.207 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

LUNGS 1.91 0.417 PAS STAIN EXAMINED

TESTIS, RT 1.87 0.408 NO SIGNIFICANT

TESTIS, LT 1.88 0.410 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

EPIDIDYMIS, LT 0.62 0.135 EYES HEART INTESTINE KIDNEYS

CAUDA EPID, LT 0.2711 0.059 LIVER LN, MESENTERIC LUNGS PANCREAS

PITUITARY 0.0159 0.003 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

EPIDIDYMIS, RT 0.66 0.144 SKIN SPLEEN STOMACH SEMINAL VESICLES

CAUDA EPID, RT 0.2960 0.065 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

FINAL BODY WT(G) 459. URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT LUNGS PITUITARY PROSTATE

 SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL

 EPIDIDYMIS, LT VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 787 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 52

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91558 GROUP 5: 10000 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 1.94 0.458 PAS STAIN EXAMINED

LIVER 13.27 3.135 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

KIDNEYS 2.95 0.697 PAS STAIN EXAMINED

SPLEEN 0.66 0.156 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

LUNGS 1.71 0.404 PAS STAIN EXAMINED

TESTIS, RT 1.62 0.383 NO SIGNIFICANT

TESTIS, LT 1.58 0.373 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

EPIDIDYMIS, LT 0.55 0.130 EYES HEART INTESTINE KIDNEYS

CAUDA EPID, LT 0.2771 0.065 LIVER LN, MESENTERIC LUNGS PANCREAS

PITUITARY 0.0107 0.003 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

EPIDIDYMIS, RT 0.62 0.146 SKIN SPLEEN STOMACH SEMINAL VESICLES

CAUDA EPID, RT 0.2652 0.063 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

FINAL BODY WT(G) 423. URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT LUNGS PITUITARY PROSTATE

 SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL

 EPIDIDYMIS, LT VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 788 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 53

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91571 GROUP 5: 10000 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 1.97 0.517 PAS STAIN EXAMINED

LIVER 13.50 3.543 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

KIDNEYS 3.14 0.824 PAS STAIN EXAMINED

SPLEEN 0.64 0.168 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

LUNGS 1.61 0.423 PAS STAIN EXAMINED

TESTIS, RT 1.50 0.394 NO SIGNIFICANT

TESTIS, LT 1.50 0.394 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

EPIDIDYMIS, LT 0.55 0.144 EYES HEART INTESTINE KIDNEYS

CAUDA EPID, LT 0.2693 0.071 LIVER LN, MESENTERIC LUNGS PANCREAS

PITUITARY 0.0125 0.003 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

EPIDIDYMIS, RT 0.58 0.152 SKIN SPLEEN STOMACH SEMINAL VESICLES

CAUDA EPID, RT 0.2648 0.070 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

FINAL BODY WT(G) 381. URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT LUNGS PITUITARY PROSTATE

 SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL

 EPIDIDYMIS, LT VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 789 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 54

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91575 GROUP 5: 10000 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 2.18 0.492 PAS STAIN EXAMINED

LIVER 14.35 3.241 KIDNEYS GROSS: DILATED PELVIS 2

KIDNEYS 3.44 0.777 RIGHT

SPLEEN 0.74 0.167 ^==> KIDNEYS: DILATATION, PELVIS

LUNGS 1.85 0.418 KIDNEYS MICRO: DILATATION, PELVIS 2

TESTIS, RT 1.60 0.361 ONE KIDNEY EXAMINED

TESTIS, LT 1.55 0.350 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

EPIDIDYMIS, LT 0.56 0.126 PAS STAIN EXAMINED

CAUDA EPID, LT 0.2104 0.048 URETERS MICRO: NOT PRESENT FOR EXAMINATION

PITUITARY 0.0122 0.003 NOT IN PLANE. FATTY TISSUE AND ARTERIOLES ONLY.

EPIDIDYMIS, RT 0.59 0.133 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

CAUDA EPID, RT 0.2488 0.056 PAS STAIN EXAMINED

FINAL BODY WT(G) 443. NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

 EYES HEART INTESTINE LIVER

 LN, MESENTERIC LUNGS PANCREAS PITUITARY

 PROSTATE SPINAL CORD SAL. GLAND MAND SKIN

 SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT

 VAS DEFERENS

 MICRO:EPIDIDYMIS, RT LUNGS PITUITARY PROSTATE

 SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL

 EPIDIDYMIS, LT VAS DEFERENS

 NOT PRESENT FOR EXAMINATION

 MICRO:URETERS

Page 790 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 55

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91575 GROUP 5: 10000 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 791 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 56

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91600 GROUP 5: 10000 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 2.13 0.475 PAS STAIN EXAMINED

LIVER 15.48 3.455 LUNGS MICRO: MINERALIZATION, VASCULAR 1

KIDNEYS 3.24 0.723 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

SPLEEN 0.78 0.174 PAS STAIN EXAMINED

LUNGS 1.63 0.364 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

TESTIS, RT 1.85 0.413 PAS STAIN EXAMINED

TESTIS, LT 1.72 0.384 NO SIGNIFICANT

EPIDIDYMIS, LT 0.64 0.143 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

CAUDA EPID, LT 0.3179 0.071 EYES HEART INTESTINE KIDNEYS

PITUITARY 0.0132 0.003 LIVER LN, MESENTERIC LUNGS PANCREAS

EPIDIDYMIS, RT 0.73 0.163 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

CAUDA EPID, RT 0.3173 0.071 SKIN SPLEEN STOMACH SEMINAL VESICLES

FINAL BODY WT(G) 448. TESTIS, RT THYMUS THYROID GLANDS TRACHEA

 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN

 SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT

 VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 792 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 57

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91603 GROUP 5: 10000 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 1.93 0.468 PAS STAIN EXAMINED

LIVER 18.11 4.396 LUNGS MICRO: ATELECTASIS 2

KIDNEYS 3.60 0.874 CONGESTION 2

SPLEEN 0.70 0.170 POST-TERMINAL

LUNGS 1.72 0.417 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

TESTIS, RT 1.74 0.422 PAS STAIN EXAMINED

TESTIS, LT 1.73 0.420 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

EPIDIDYMIS, LT 0.66 0.160 PAS STAIN EXAMINED

CAUDA EPID, LT 0.2831 0.069 NO SIGNIFICANT

PITUITARY 0.0123 0.003 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

EPIDIDYMIS, RT 0.68 0.165 EYES HEART INTESTINE KIDNEYS

CAUDA EPID, RT 0.2552 0.062 LIVER LN, MESENTERIC LUNGS PANCREAS

FINAL BODY WT(G) 412. PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

 SKIN SPLEEN STOMACH SEMINAL VESICLES

 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN

 SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT

 VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 793 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 58

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91604 GROUP 5: 10000 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 1.89 0.438 PAS STAIN EXAMINED

LIVER 15.12 3.502 KIDNEYS GROSS: AREA(S), DEPRESSED P

KIDNEYS 3.14 0.727 FEW, 2 MM IN DIAMETER, IN CORTEX, LEFT

SPLEEN 0.70 0.162 ^==> KIDNEYS: DEGENERATION, TUBULAR

LUNGS 1.64 0.380 KIDNEYS MICRO: DEGENERATION, TUBULAR 1

TESTIS, RT 1.75 0.405 FOCAL, SINGLE TUBULE DROPOUT

TESTIS, LT 1.71 0.396 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

EPIDIDYMIS, LT 0.64 0.148 PAS STAIN EXAMINED

CAUDA EPID, LT 0.2876 0.067 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

PITUITARY 0.0149 0.003 PAS STAIN EXAMINED

EPIDIDYMIS, RT 0.68 0.157 NO SIGNIFICANT

CAUDA EPID, RT 0.2619 0.061 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

FINAL BODY WT(G) 432. EYES HEART INTESTINE LIVER

 LN, MESENTERIC LUNGS PANCREAS PITUITARY

 PROSTATE SPINAL CORD SAL. GLAND MAND SKIN

 SPLEEN STOMACH SEMINAL VESICLES TESTIS, RT

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 DIAPHRAGM COAGULATING GL TESTIS, LT EPIDIDYMIS, LT

 VAS DEFERENS

 MICRO:EPIDIDYMIS, RT LUNGS PITUITARY PROSTATE

 SPLEEN SEMINAL VESICLES TESTIS, RT COAGULATING GL

 EPIDIDYMIS, LT VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 794 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 59

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91605 GROUP 5: 10000 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 2.00 0.500 PAS STAIN EXAMINED

LIVER 13.23 3.307 LUNGS MICRO: MINERALIZATION, VASCULAR 1

KIDNEYS 2.96 0.740 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

SPLEEN 0.65 0.162 PAS STAIN EXAMINED

LUNGS 1.41 0.352 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

TESTIS, RT 1.83 0.458 PAS STAIN EXAMINED

TESTIS, LT 1.86 0.465 NO SIGNIFICANT

EPIDIDYMIS, LT 0.60 0.150 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

CAUDA EPID, LT 0.3019 0.075 EYES HEART INTESTINE KIDNEYS

PITUITARY 0.0127 0.003 LIVER LN, MESENTERIC LUNGS PANCREAS

EPIDIDYMIS, RT 0.61 0.153 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

CAUDA EPID, RT 0.2506 0.063 SKIN SPLEEN STOMACH SEMINAL VESICLES

FINAL BODY WT(G) 400. TESTIS, RT THYMUS THYROID GLANDS TRACHEA

 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN

 SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT

 VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 795 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 60

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91612 GROUP 5: 10000 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 2.16 0.557 PAS STAIN EXAMINED

LIVER 14.21 3.662 LUNGS MICRO: MINERALIZATION, VASCULAR 1

KIDNEYS 3.12 0.804 PROSTATE MICRO: INFLAMMATION, SUBACUTE 2

SPLEEN 0.69 0.178 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

LUNGS 1.39 0.358 PAS STAIN EXAMINED

TESTIS, RT 1.90 0.490 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

TESTIS, LT 1.86 0.479 PAS STAIN EXAMINED

EPIDIDYMIS, LT 0.66 0.170 NO SIGNIFICANT

CAUDA EPID, LT 0.3086 0.080 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

PITUITARY 0.0134 0.003 EYES HEART INTESTINE KIDNEYS

EPIDIDYMIS, RT 0.74 0.191 LIVER LN, MESENTERIC LUNGS PANCREAS

CAUDA EPID, RT 0.2796 0.072 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

FINAL BODY WT(G) 388. SKIN SPLEEN STOMACH SEMINAL VESICLES

 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT PITUITARY SPLEEN SEMINAL VESICLES

 TESTIS, RT COAGULATING GL EPIDIDYMIS, LT VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 796 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 61

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91618 GROUP 5: 10000 PPM MALE SCHEDULED EUTH 11/12/13 DATE OF DEATH: 11/12/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 2.17 0.531 PAS STAIN EXAMINED

LIVER 14.65 3.582 LUNGS MICRO: MINERALIZATION, VASCULAR 1

KIDNEYS 3.35 0.819 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

SPLEEN 0.83 0.203 PAS STAIN EXAMINED

LUNGS 1.62 0.396 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

TESTIS, RT 1.59 0.389 PAS STAIN EXAMINED

TESTIS, LT 1.55 0.379 NO SIGNIFICANT

EPIDIDYMIS, LT 0.58 0.142 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

CAUDA EPID, LT 0.2653 0.065 EYES HEART INTESTINE KIDNEYS

PITUITARY 0.0157 0.004 LIVER LN, MESENTERIC LUNGS PANCREAS

EPIDIDYMIS, RT 0.63 0.154 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

CAUDA EPID, RT 0.2693 0.066 SKIN SPLEEN STOMACH SEMINAL VESICLES

FINAL BODY WT(G) 409. TESTIS, RT THYMUS THYROID GLANDS TRACHEA

 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN

 SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT

 VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

Page 797 of 1107
 TABLE A39 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 62

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91619 GROUP 5: 10000 PPM MALE SCHEDULED EUTH 11/11/13 DATE OF DEATH: 11/11/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. EPIDIDYMIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

BRAIN 2.05 0.500 PAS STAIN EXAMINED

LIVER 13.77 3.359 LUNGS MICRO: ATELECTASIS 3

KIDNEYS 3.24 0.790 POST-TERMINAL

SPLEEN 0.74 0.180 TESTIS, RT MICRO: NO SIGNIFICANT CHANGES OBSERVED

LUNGS 1.68 0.410 PAS STAIN EXAMINED

TESTIS, RT 1.61 0.393 EPIDIDYMIS, LT MICRO: NO SIGNIFICANT CHANGES OBSERVED

TESTIS, LT 1.62 0.395 PAS STAIN EXAMINED

EPIDIDYMIS, LT 0.53 0.129 NO SIGNIFICANT

CAUDA EPID, LT 0.2584 0.063 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN EPIDIDYMIS, RT ESOPHAGUS

PITUITARY 0.0131 0.003 EYES HEART INTESTINE KIDNEYS

EPIDIDYMIS, RT 0.56 0.137 LIVER LN, MESENTERIC LUNGS PANCREAS

CAUDA EPID, RT 0.2330 0.057 PITUITARY PROSTATE SPINAL CORD SAL. GLAND MAND

FINAL BODY WT(G) 410. SKIN SPLEEN STOMACH SEMINAL VESICLES

 TESTIS, RT THYMUS THYROID GLANDS TRACHEA

 URINARY BLADDER DIAPHRAGM COAGULATING GL TESTIS, LT

 EPIDIDYMIS, LT VAS DEFERENS

 MICRO:EPIDIDYMIS, RT PITUITARY PROSTATE SPLEEN

 SEMINAL VESICLES TESTIS, RT COAGULATING GL EPIDIDYMIS, LT

 VAS DEFERENS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 PGRHv4.68

 02/18/2014

Page 798 of 1107
 TABLE A40 (F0 FEMALES - FAILED TO DELIVER)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91623 GROUP 4: 175 PPM FEMALE SCHEDULED EUTH 12/05/13 DATE OF DEATH: 12/05/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: NONGRAVID- AMMONIUM SULFIDE NEGATIVE P

BRAIN 1.88 0.608 ^==> GROSS UNCONFIRMED

LIVER 11.03 3.565 UTERUS GROSS: CONTENTS, CLEAR FLUID P

KIDNEYS 2.06 0.666 BOTH HORNS

SPLEEN 0.59 0.191 ^==> GROSS UNCONFIRMED

LUNGS 1.75 0.566 NO SIGNIFICANT

OVARIES 0.1358 0.044 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

PITUITARY 0.0154 0.005 HEART INTESTINE KIDNEYS LIVER

FINAL BODY WT(G) 309. LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 CERVIX VAGINA DIAPHRAGM

 MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY

 SPLEEN CERVIX VAGINA

 NOT PRESENT FOR EXAMINATION

 MICRO:UTERUS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

 PGRHv4.68

 02/18/2014

Page 799 of 1107
 TABLE A41 (F0 FEMALES - TOTAL LITTER LOSS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91654 GROUP 4: 175 PPM FEMALE SCHEDULED EUTH 11/27/13 DATE OF DEATH: 11/27/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 2.00 8,11

LIVER 16.62 ^==> GROSS UNCONFIRMED

KIDNEYS 2.25 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.92 8,11

LUNGS 1.50 ^==> GROSS UNCONFIRMED

OVARIES 0.1465 PITUITARY MICRO: CYST, PARS DISTALIS P

PITUITARY 0.0167 UTERUS MICRO: IMPLANTATION SITE P

 BILATERAL

 EXUDATE, INFLAMMATORY 2

 WITHIN LUMEN OF UTERUS; NEUTROPHILS

 NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:LUNGS MAMMARY GLAND OVARIES SPLEEN

 CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

 PGRHv4.68

 02/18/2014

Page 800 of 1107
FINAL REPORT

Contents: Volume 4 of 4 

Appendix G (continued)

Study Title: An Inhalation Reproduction/Developmental Toxicity

Screening Study of 2-Bromo-3,3,3-Trifluoropropene in Rats

Laboratory Project ID: WIL-65501

Author: Tammye L. Edwards, BS

Test Guideline: OECD Guideline 421

Study Completion Date: 21 March 2014

Performing Laboratory: WIL Research

1407 George Road

Ashland, OH 44805-8946

Sponsor: American Pacific Corporation

3883 Howard Hughes Parkway, Suite 700

Las Vegas, NV 89169

Total Number of Pages: 1107

 Page 801 of 1107
WIL-65501 2-Bromo-3,3,3-Trifluoropropene

American Pacific Corporation

APPENDIX G

Individual Animal Data (continued)

 Page 802 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91629 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 11/25/13 DATE OF DEATH: 11/25/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.96 0.636 8,8

LIVER 12.71 4.127 ^==> GROSS UNCONFIRMED

KIDNEYS 2.16 0.701 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.67 0.218 8,8

LUNGS 1.47 0.477 ^==> GROSS UNCONFIRMED

OVARIES 0.1023 0.033 LUNGS MICRO: MINERALIZATION, VASCULAR 1

PITUITARY 0.0143 0.005 UTERUS MICRO: IMPLANTATION SITE P

FINAL BODY WT(G) 308. BILATERAL

 NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:MAMMARY GLAND OVARIES PITUITARY SPLEEN

 CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 803 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91630 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 11/26/13 DATE OF DEATH: 11/26/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.96 0.605 10,6

LIVER 15.97 4.929 ^==> GROSS UNCONFIRMED

KIDNEYS 2.32 0.716 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.59 0.182 10,6

LUNGS 1.53 0.472 ^==> GROSS UNCONFIRMED

OVARIES 0.0903 0.028 LUNGS MICRO: ATELECTASIS 3

PITUITARY 0.0198 0.006 POST-TERMINAL

FINAL BODY WT(G) 324. UTERUS MICRO: IMPLANTATION SITE P

 BILATERAL

 NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:MAMMARY GLAND OVARIES PITUITARY SPLEEN

 CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 804 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91633 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 11/23/13 DATE OF DEATH: 11/23/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 2.02 0.560 11,5

LIVER 14.39 3.986 ^==> GROSS UNCONFIRMED

KIDNEYS 2.41 0.668 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.82 0.227 11,6

LUNGS 1.33 0.368 ^==> GROSS UNCONFIRMED

OVARIES 0.1462 0.040 UTERUS MICRO: IMPLANTATION SITE P

PITUITARY 0.0214 0.006 UNILATERAL

FINAL BODY WT(G) 361. NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY

 SPLEEN CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 805 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91637 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 11/22/13 DATE OF DEATH: 11/22/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.94 0.606 8,7

LIVER 12.77 3.991 ^==> GROSS UNCONFIRMED

KIDNEYS 2.31 0.722 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.64 0.200 8,7

LUNGS 1.25 0.391 ^==> GROSS UNCONFIRMED

OVARIES 0.1021 0.032 LUNGS MICRO: MINERALIZATION, VASCULAR 1

PITUITARY 0.0173 0.005 UTERUS MICRO: IMPLANTATION SITE P

FINAL BODY WT(G) 320. UNILATERAL

 NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:MAMMARY GLAND OVARIES PITUITARY SPLEEN

 CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 806 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91639 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 11/25/13 DATE OF DEATH: 11/25/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.95 0.540 6,11

LIVER 14.15 3.920 ^==> GROSS UNCONFIRMED

KIDNEYS 2.13 0.590 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.65 0.180 8,12

LUNGS 1.54 0.427 ^==> GROSS UNCONFIRMED

OVARIES 0.1524 0.042 LUNGS MICRO: MINERALIZATION, VASCULAR 1

PITUITARY 0.0201 0.006 UTERUS MICRO: IMPLANTATION SITE P

FINAL BODY WT(G) 361. UNILATERAL

 NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:MAMMARY GLAND OVARIES PITUITARY SPLEEN

 CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 807 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91644 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 11/23/13 DATE OF DEATH: 11/23/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.89 0.604 7,11

LIVER 13.08 4.179 ^==> GROSS UNCONFIRMED

KIDNEYS 2.37 0.757 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.66 0.211 7,11

LUNGS 1.57 0.502 ^==> GROSS UNCONFIRMED

OVARIES 0.1213 0.039 OVARIES MICRO: CYST, FOLLICULAR P

PITUITARY 0.0225 0.007 SOLITARY, ON SLIDE 11A

FINAL BODY WT(G) 313. UTERUS MICRO: IMPLANTATION SITE P

 UNILATERAL

 NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:LUNGS MAMMARY GLAND PITUITARY SPLEEN

 CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 808 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91645 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 11/26/13 DATE OF DEATH: 11/26/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.98 0.579 7,9

LIVER 15.82 4.626 ^==> GROSS UNCONFIRMED

KIDNEYS 2.32 0.678 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.61 0.178 7,9

LUNGS 1.50 0.439 ^==> GROSS UNCONFIRMED

OVARIES 0.1106 0.032 UTERUS MICRO: IMPLANTATION SITE P

PITUITARY 0.0201 0.006 BILATERAL

FINAL BODY WT(G) 342. NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY

 SPLEEN CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 809 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91648 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 11/23/13 DATE OF DEATH: 11/23/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.95 0.543 6,8

LIVER 14.92 4.156 ^==> GROSS UNCONFIRMED

KIDNEYS 2.34 0.652 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.77 0.214 6,9

LUNGS 1.47 0.409 ^==> GROSS UNCONFIRMED

OVARIES 0.1255 0.035 UTERUS MICRO: IMPLANTATION SITE P

PITUITARY 0.0203 0.006 BILATERAL

FINAL BODY WT(G) 359. NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY

 SPLEEN CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 810 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91653 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 11/25/13 DATE OF DEATH: 11/25/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.95 0.562 7,10

LIVER 13.47 3.882 ^==> GROSS UNCONFIRMED

KIDNEYS 2.20 0.634 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.75 0.216 7,10

LUNGS 1.19 0.343 ^==> GROSS UNCONFIRMED

OVARIES 0.1329 0.038 LUNGS MICRO: ATELECTASIS 2

PITUITARY 0.0220 0.006 UTERUS MICRO: IMPLANTATION SITE P

FINAL BODY WT(G) 347. UNILATERAL

 NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:MAMMARY GLAND OVARIES PITUITARY SPLEEN

 CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 811 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91660 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 11/25/13 DATE OF DEATH: 11/25/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 2.09 0.568 7,8

LIVER 15.74 4.277 ^==> GROSS UNCONFIRMED

KIDNEYS 2.42 0.658 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.72 0.196 8,10

LUNGS 1.53 0.416 ^==> GROSS UNCONFIRMED

OVARIES 0.1325 0.036 UTERUS MICRO: IMPLANTATION SITE P

PITUITARY 0.0271 0.007 BILATERAL

FINAL BODY WT(G) 368. NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY

 SPLEEN CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 812 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 11

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91670 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 11/26/13 DATE OF DEATH: 11/26/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 2.01 0.605 6,8

LIVER 13.90 4.187 ^==> GROSS UNCONFIRMED

KIDNEYS 2.31 0.696 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.59 0.178 6,8

LUNGS 1.43 0.431 ^==> GROSS UNCONFIRMED

OVARIES 0.1371 0.041 UTERUS MICRO: IMPLANTATION SITE P

PITUITARY 0.0205 0.006 BILATERAL

FINAL BODY WT(G) 332. NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY

 SPLEEN CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 813 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 12

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91672 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 11/26/13 DATE OF DEATH: 11/26/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 2.06 0.551 6,10

LIVER 17.93 4.794 ^==> GROSS UNCONFIRMED

KIDNEYS 2.37 0.634 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.91 0.243 6,10

LUNGS 1.76 0.471 ^==> GROSS UNCONFIRMED

OVARIES 0.1561 0.042 UTERUS MICRO: IMPLANTATION SITE P

PITUITARY 0.0229 0.006 BILATERAL

FINAL BODY WT(G) 374. CERVIX MICRO: NO SIGNIFICANT CHANGES OBSERVED

 MULTIPLE IMPLANTATION SITES OBSERVED IN CERVIX SECTION

 NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY

 SPLEEN CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 814 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 13

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91632 GROUP 2: 50 PPM FEMALE SCHEDULED EUTH 11/27/13 DATE OF DEATH: 11/27/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.87 0.583 6,9

LIVER 12.83 3.997 ^==> GROSS UNCONFIRMED

KIDNEYS 2.39 0.745 GENERAL COMMENT GROSS: ORGAN DAMAGED AT NECROPSY P

SPLEEN 0.59 0.184 BRAIN

LUNGS 1.45 0.452 ^==> GROSS UNCONFIRMED

OVARIES 0.1072 0.033 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

PITUITARY 0.0188 0.006 6,10

FINAL BODY WT(G) 321. ^==> GROSS UNCONFIRMED

 NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 815 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 14

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91640 GROUP 2: 50 PPM FEMALE SCHEDULED EUTH 11/27/13 DATE OF DEATH: 11/27/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 2.02 0.558 5,9

LIVER 15.05 4.157 ^==> GROSS UNCONFIRMED

KIDNEYS 2.55 0.704 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 1.09 0.301 8,9

LUNGS 1.89 0.522 ^==> GROSS UNCONFIRMED

OVARIES 0.1252 0.035 GENERAL COMMENT GROSS: ORGAN DAMAGED AT NECROPSY P

PITUITARY 0.0206 0.006 BRAIN

FINAL BODY WT(G) 362. ^==> GROSS UNCONFIRMED

 NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 816 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 15

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91642 GROUP 2: 50 PPM FEMALE SCHEDULED EUTH 11/24/13 DATE OF DEATH: 11/24/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.88 0.539 5,10

LIVER 14.48 4.149 ^==> GROSS UNCONFIRMED

KIDNEYS 2.53 0.725 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.80 0.229 5,11

LUNGS 1.51 0.433 ^==> GROSS UNCONFIRMED

OVARIES 0.0948 0.027 NO SIGNIFICANT

PITUITARY 0.0212 0.006 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

FINAL BODY WT(G) 349. HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 817 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 16

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91647 GROUP 2: 50 PPM FEMALE SCHEDULED EUTH 11/26/13 DATE OF DEATH: 11/26/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.80 0.608 6,7

LIVER 12.87 4.348 ^==> GROSS UNCONFIRMED

KIDNEYS 2.04 0.689 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.58 0.196 6,7

LUNGS 1.39 0.470 ^==> GROSS UNCONFIRMED

OVARIES 0.0989 0.033 KIDNEYS GROSS: PALE P

PITUITARY 0.0189 0.006 BILATERAL

FINAL BODY WT(G) 296. ^==> GROSS UNCONFIRMED

 NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE LIVER LN, MESENTERIC

 LUNGS MAMMARY GLAND OVIDUCTS OVARIES

 PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND

 SKIN SPLEEN STOMACH THYMUS

 THYROID GLANDS TRACHEA URINARY BLADDER UTERUS

 CERVIX VAGINA DIAPHRAGM

 MICRO:KIDNEYS

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 818 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 17

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91651 GROUP 2: 50 PPM FEMALE SCHEDULED EUTH 11/25/13 DATE OF DEATH: 11/25/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.91 0.581 6,8

LIVER 14.86 4.517 ^==> GROSS UNCONFIRMED

KIDNEYS 2.37 0.720 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.61 0.185 6,8

LUNGS 1.69 0.514 ^==> GROSS UNCONFIRMED

OVARIES 0.0894 0.027 NO SIGNIFICANT

PITUITARY 0.0168 0.005 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

FINAL BODY WT(G) 329. HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 819 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 18

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91659 GROUP 2: 50 PPM FEMALE SCHEDULED EUTH 11/24/13 DATE OF DEATH: 11/24/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 2.10 0.566 7,7

LIVER 16.38 4.415 ^==> GROSS UNCONFIRMED

KIDNEYS 2.43 0.655 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.82 0.221 7,7

LUNGS 1.51 0.407 ^==> GROSS UNCONFIRMED

OVARIES 0.1208 0.033 NO SIGNIFICANT

PITUITARY 0.0205 0.006 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

FINAL BODY WT(G) 371. HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 820 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 19

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91661 GROUP 2: 50 PPM FEMALE SCHEDULED EUTH 11/23/13 DATE OF DEATH: 11/23/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.92 0.610 10,7

LIVER 13.20 4.190 ^==> GROSS UNCONFIRMED

KIDNEYS 2.35 0.746 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.61 0.194 10,7

LUNGS 1.54 0.489 ^==> GROSS UNCONFIRMED

OVARIES 0.1072 0.034 NO SIGNIFICANT

PITUITARY 0.0160 0.005 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

FINAL BODY WT(G) 315. HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 821 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 20

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91663 GROUP 2: 50 PPM FEMALE SCHEDULED EUTH 11/25/13 DATE OF DEATH: 11/25/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.94 0.599 4,11

LIVER 12.37 3.818 ^==> GROSS UNCONFIRMED

KIDNEYS 2.13 0.657 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.64 0.198 4,11

LUNGS 1.40 0.432 ^==> GROSS UNCONFIRMED

OVARIES 0.1085 0.033 NO SIGNIFICANT

PITUITARY 0.0183 0.006 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

FINAL BODY WT(G) 324. HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 822 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 21

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91669 GROUP 2: 50 PPM FEMALE SCHEDULED EUTH 11/23/13 DATE OF DEATH: 11/23/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 2.09 0.643 8,8

LIVER 13.48 4.148 ^==> GROSS UNCONFIRMED

KIDNEYS 2.11 0.649 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.84 0.258 8,8

LUNGS 1.49 0.458 ^==> GROSS UNCONFIRMED

OVARIES 0.1419 0.044 NO SIGNIFICANT

PITUITARY 0.0171 0.005 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

FINAL BODY WT(G) 325. HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 823 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 22

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91673 GROUP 2: 50 PPM FEMALE SCHEDULED EUTH 11/26/13 DATE OF DEATH: 11/26/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 2.00 0.623 4,12

LIVER 14.97 4.664 ^==> GROSS UNCONFIRMED

KIDNEYS 2.51 0.782 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.70 0.218 4,12

LUNGS 1.65 0.514 ^==> GROSS UNCONFIRMED

OVARIES 0.1319 0.041 NO SIGNIFICANT

PITUITARY 0.0200 0.006 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

FINAL BODY WT(G) 321. HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 824 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 23

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91683 GROUP 2: 50 PPM FEMALE SCHEDULED EUTH 11/27/13 DATE OF DEATH: 11/27/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.89 0.589 8,5

LIVER 13.75 4.283 ^==> GROSS UNCONFIRMED

KIDNEYS 2.19 0.682 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.74 0.231 8,6

LUNGS 1.43 0.445 ^==> GROSS UNCONFIRMED

OVARIES 0.1099 0.034 NO SIGNIFICANT

PITUITARY 0.0194 0.006 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

FINAL BODY WT(G) 321. HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 825 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 24

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91685 GROUP 2: 50 PPM FEMALE SCHEDULED EUTH 11/23/13 DATE OF DEATH: 11/23/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 2.04 0.699 6,4

LIVER 11.44 3.918 ^==> GROSS UNCONFIRMED

KIDNEYS 2.02 0.692 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.57 0.195 6,10

LUNGS 1.45 0.497 ^==> GROSS UNCONFIRMED

OVARIES 0.1351 0.046 NO SIGNIFICANT

PITUITARY 0.0198 0.007 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

FINAL BODY WT(G) 292. HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 826 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 25

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91620 GROUP 3: 100 PPM FEMALE SCHEDULED EUTH 11/26/13 DATE OF DEATH: 11/26/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.89 0.538 7,8

LIVER 13.72 3.909 ^==> GROSS UNCONFIRMED

KIDNEYS 2.31 0.658 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.98 0.279 7,8

LUNGS 1.44 0.410 ^==> GROSS UNCONFIRMED

OVARIES 0.1291 0.037 NO SIGNIFICANT

PITUITARY 0.0166 0.005 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

FINAL BODY WT(G) 351. HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 827 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 26

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91628 GROUP 3: 100 PPM FEMALE SCHEDULED EUTH 11/24/13 DATE OF DEATH: 11/24/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.93 0.668 10,5

LIVER 12.30 4.256 ^==> GROSS UNCONFIRMED

KIDNEYS 2.02 0.699 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.59 0.204 10,5

LUNGS 1.39 0.481 ^==> GROSS UNCONFIRMED

OVARIES 0.1142 0.040 NO SIGNIFICANT

PITUITARY 0.0161 0.006 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

FINAL BODY WT(G) 289. HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 828 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 27

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91631 GROUP 3: 100 PPM FEMALE SCHEDULED EUTH 11/24/13 DATE OF DEATH: 11/24/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.87 0.533 4,11

LIVER 15.89 4.527 ^==> GROSS UNCONFIRMED

KIDNEYS 2.79 0.795 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.76 0.217 7,12

LUNGS 1.43 0.407 ^==> GROSS UNCONFIRMED

OVARIES 0.1094 0.031 NO SIGNIFICANT

PITUITARY 0.0159 0.005 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

FINAL BODY WT(G) 351. HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 829 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 28

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91636 GROUP 3: 100 PPM FEMALE SCHEDULED EUTH 11/25/13 DATE OF DEATH: 11/25/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.86 0.644 9,7

LIVER 12.10 4.187 ^==> GROSS UNCONFIRMED

KIDNEYS 2.07 0.716 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.72 0.249 9,7

LUNGS 1.41 0.488 ^==> GROSS UNCONFIRMED

OVARIES 0.1071 0.037 NO SIGNIFICANT

PITUITARY 0.0176 0.006 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

FINAL BODY WT(G) 289. HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 830 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 29

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91649 GROUP 3: 100 PPM FEMALE SCHEDULED EUTH 11/23/13 DATE OF DEATH: 11/23/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.87 0.613 8,8

LIVER 13.32 4.367 ^==> GROSS UNCONFIRMED

KIDNEYS 2.22 0.728 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.89 0.292 8,8

LUNGS 1.47 0.482 ^==> GROSS UNCONFIRMED

OVARIES 0.1284 0.042 NO SIGNIFICANT

PITUITARY 0.0121 0.004 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

FINAL BODY WT(G) 305. HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 831 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 30

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91650 GROUP 3: 100 PPM FEMALE SCHEDULED EUTH 11/23/13 DATE OF DEATH: 11/23/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.88 0.530 9,5

LIVER 14.91 4.200 ^==> GROSS UNCONFIRMED

KIDNEYS 2.46 0.693 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.94 0.265 9,6

LUNGS 1.62 0.456 ^==> GROSS UNCONFIRMED

OVARIES 0.1214 0.034 NO SIGNIFICANT

PITUITARY 0.0210 0.006 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

FINAL BODY WT(G) 355. HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 832 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 31

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91656 GROUP 3: 100 PPM FEMALE SCHEDULED EUTH 11/28/13 DATE OF DEATH: 11/28/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.93 0.585 8,8

LIVER 13.29 4.027 ^==> GROSS UNCONFIRMED

KIDNEYS 2.22 0.673 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.60 0.182 8,9

LUNGS 1.51 0.458 ^==> GROSS UNCONFIRMED

OVARIES 0.0969 0.029 NO SIGNIFICANT

PITUITARY 0.0159 0.005 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

FINAL BODY WT(G) 330. HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 833 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 32

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91671 GROUP 3: 100 PPM FEMALE SCHEDULED EUTH 11/28/13 DATE OF DEATH: 11/28/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.90 0.549 6,9

LIVER 14.61 4.223 ^==> GROSS UNCONFIRMED

KIDNEYS 2.22 0.642 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 1.19 0.344 6,9

LUNGS 1.41 0.408 ^==> GROSS UNCONFIRMED

OVARIES 0.1100 0.032 NO SIGNIFICANT

PITUITARY 0.0179 0.005 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

FINAL BODY WT(G) 346. HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 834 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 33

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91675 GROUP 3: 100 PPM FEMALE SCHEDULED EUTH 11/24/13 DATE OF DEATH: 11/24/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 2.06 0.574 5,9

LIVER 14.93 4.159 ^==> GROSS UNCONFIRMED

KIDNEYS 2.45 0.682 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.91 0.253 5, 9

LUNGS 1.56 0.435 ^==> GROSS UNCONFIRMED

OVARIES 0.1321 0.037 GENERAL COMMENT GROSS: ORGAN DAMAGED AT NECROPSY P

PITUITARY 0.0140 0.004 BRAIN

FINAL BODY WT(G) 359. ^==> GROSS UNCONFIRMED

 NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 835 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 34

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91677 GROUP 3: 100 PPM FEMALE SCHEDULED EUTH 11/25/13 DATE OF DEATH: 11/25/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 2.00 0.647 5,1

LIVER 11.13 3.602 ^==> GROSS UNCONFIRMED

KIDNEYS 2.20 0.712 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.66 0.214 5,11

LUNGS 1.37 0.443 ^==> GROSS UNCONFIRMED

OVARIES 0.1184 0.038 SPLEEN GROSS: ADHESIONS P

PITUITARY 0.0138 0.004 ATTACHED TO ADIPOSE TISSUE ADJACENT TO PANCREAS

FINAL BODY WT(G) 309. ^==> SPLEEN: FIBROSIS, CAPSULAR

 SPLEEN MICRO: FIBROSIS, CAPSULAR 2

 COMPATIBLE WITH ADHESION

 NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN STOMACH THYMUS

 THYROID GLANDS TRACHEA URINARY BLADDER UTERUS

 CERVIX VAGINA DIAPHRAGM

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 836 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 35

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91679 GROUP 3: 100 PPM FEMALE SCHEDULED EUTH 11/23/13 DATE OF DEATH: 11/23/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.94 0.574 6,9

LIVER 13.87 4.104 ^==> GROSS UNCONFIRMED

KIDNEYS 2.25 0.666 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 1.15 0.340 6,9

LUNGS 1.90 0.562 ^==> GROSS UNCONFIRMED

OVARIES 0.1544 0.046 NO SIGNIFICANT

PITUITARY 0.0126 0.004 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

FINAL BODY WT(G) 338. HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 837 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 36

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91684 GROUP 3: 100 PPM FEMALE SCHEDULED EUTH 11/24/13 DATE OF DEATH: 11/24/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.96 0.685 7,9

LIVER 12.90 4.510 ^==> GROSS UNCONFIRMED

KIDNEYS 1.76 0.615 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.53 0.185 7,9

LUNGS 1.48 0.517 ^==> GROSS UNCONFIRMED

OVARIES 0.1091 0.038 NO SIGNIFICANT

PITUITARY 0.0132 0.005 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

FINAL BODY WT(G) 286. HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 838 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 37

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91622 GROUP 4: 175 PPM FEMALE SCHEDULED EUTH 11/23/13 DATE OF DEATH: 11/23/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.96 0.651 4,11

LIVER 14.01 4.654 ^==> GROSS UNCONFIRMED

KIDNEYS 2.10 0.698 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.96 0.319 4,11

LUNGS 1.68 0.558 ^==> GROSS UNCONFIRMED

OVARIES 0.1147 0.038 OVARIES MICRO: NO SIGNIFICANT CHANGES OBSERVED

PITUITARY 0.0162 0.005 MINIMAL TISSUE OTHER THAN CORPORA LUTEA

FINAL BODY WT(G) 301. UTERUS MICRO: IMPLANTATION SITE P

 NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY

 SPLEEN CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 839 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 38

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91626 GROUP 4: 175 PPM FEMALE SCHEDULED EUTH 11/26/13 DATE OF DEATH: 11/26/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 2.14 0.583 8,7

LIVER 15.70 4.278 ^==> GROSS UNCONFIRMED

KIDNEYS 2.26 0.616 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.77 0.210 8,7

LUNGS 1.54 0.420 ^==> GROSS UNCONFIRMED

OVARIES 0.1211 0.033 UTERUS MICRO: IMPLANTATION SITE P

PITUITARY 0.0247 0.007 BILATERAL

FINAL BODY WT(G) 367. NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY

 SPLEEN CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 840 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 39

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91643 GROUP 4: 175 PPM FEMALE SCHEDULED EUTH 11/29/13 DATE OF DEATH: 11/29/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 2.07 0.575 6,9

LIVER 15.14 4.206 ^==> GROSS UNCONFIRMED

KIDNEYS 2.32 0.644 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 1.13 0.314 7,11

LUNGS 1.60 0.444 ^==> GROSS UNCONFIRMED

OVARIES 0.1118 0.031 OVARIES MICRO: NO SIGNIFICANT CHANGES OBSERVED

PITUITARY 0.0199 0.006 NO FOLLICLES IN THE SMALL AMOUNT OF STROMA PRESENT

FINAL BODY WT(G) 360. PITUITARY MICRO: NO SIGNIFICANT CHANGES OBSERVED

 PARS DISTALIS ONLY

 UTERUS MICRO: IMPLANTATION SITE P

 BILATERAL

 NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY

 SPLEEN CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 841 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 40

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91657 GROUP 4: 175 PPM FEMALE SCHEDULED EUTH 12/04/13 DATE OF DEATH: 12/04/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.89 0.534 9,7

LIVER 14.64 4.136 ^==> GROSS UNCONFIRMED

KIDNEYS 2.70 0.763 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.77 0.218 9,8

LUNGS 1.64 0.463 ^==> GROSS UNCONFIRMED

OVARIES 0.1375 0.039 UTERUS MICRO: IMPLANTATION SITE P

PITUITARY 0.0174 0.005 BILATERAL

FINAL BODY WT(G) 354. NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY

 SPLEEN CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 842 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 41

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91662 GROUP 4: 175 PPM FEMALE SCHEDULED EUTH 11/26/13 DATE OF DEATH: 11/26/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.92 0.582 8,7

LIVER 14.66 4.442 ^==> GROSS UNCONFIRMED

KIDNEYS 2.39 0.724 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.76 0.230 9,9

LUNGS 1.53 0.464 ^==> GROSS UNCONFIRMED

OVARIES 0.1244 0.038 OVARIES MICRO: HEMORRHAGE 2

PITUITARY 0.0147 0.004 FOCAL, WITHIN CORPORA LUTEUM

FINAL BODY WT(G) 330. UTERUS MICRO: IMPLANTATION SITE P

 BILATERAL

 NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:LUNGS MAMMARY GLAND PITUITARY SPLEEN

 CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 843 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 42

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91666 GROUP 4: 175 PPM FEMALE SCHEDULED EUTH 11/24/13 DATE OF DEATH: 11/24/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.88 0.660 6,6

LIVER 11.95 4.193 ^==> GROSS UNCONFIRMED

KIDNEYS 2.03 0.712 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.79 0.277 7,6

LUNGS 1.42 0.498 ^==> GROSS UNCONFIRMED

OVARIES 0.0850 0.030 UTERUS MICRO: IMPLANTATION SITE P

PITUITARY 0.0105 0.004 BILATERAL

FINAL BODY WT(G) 285. NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY

 SPLEEN CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 844 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 43

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91676 GROUP 4: 175 PPM FEMALE SCHEDULED EUTH 11/25/13 DATE OF DEATH: 11/25/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.97 0.621 5,9

LIVER 13.90 4.385 ^==> GROSS UNCONFIRMED

KIDNEYS 2.42 0.763 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.80 0.252 5,9

LUNGS 1.46 0.461 ^==> GROSS UNCONFIRMED

OVARIES 0.0890 0.028 UTERUS MICRO: IMPLANTATION SITE P

PITUITARY 0.0174 0.005 BILATERAL

FINAL BODY WT(G) 317. NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY

 SPLEEN CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 845 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 44

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91678 GROUP 4: 175 PPM FEMALE SCHEDULED EUTH 11/24/13 DATE OF DEATH: 11/24/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 2.08 0.525 9,8

LIVER 16.10 4.066 ^==> GROSS UNCONFIRMED

KIDNEYS 2.38 0.601 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.90 0.227 9,8

LUNGS 1.61 0.407 ^==> GROSS UNCONFIRMED

OVARIES 0.1343 0.034 OVARIES MICRO: NO SIGNIFICANT CHANGES OBSERVED

PITUITARY 0.0221 0.006 ONE OVARY HAS ONLY CORPORA LUTEA IN SECTION

FINAL BODY WT(G) 396. UTERUS MICRO: IMPLANTATION SITE P

 BILATERAL

 NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY

 SPLEEN CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 846 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 45

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91681 GROUP 4: 175 PPM FEMALE SCHEDULED EUTH 12/03/13 DATE OF DEATH: 12/03/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 2.00 0.625 6,9

LIVER 13.84 4.325 ^==> GROSS UNCONFIRMED

KIDNEYS 2.26 0.706 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.69 0.216 6,9

LUNGS 1.49 0.466 ^==> GROSS UNCONFIRMED

OVARIES 0.1230 0.038 SPLEEN GROSS: ADHESIONS P

PITUITARY 0.0170 0.005 ATTACHED TO PANCREAS

FINAL BODY WT(G) 320. ^==> SPLEEN: FIBROSIS, CAPSULAR

 SPLEEN MICRO: FIBROSIS, CAPSULAR 2

 COMPATIBLE WITH ADHESION

 NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN STOMACH THYMUS

 THYROID GLANDS TRACHEA URINARY BLADDER UTERUS

 CERVIX VAGINA DIAPHRAGM

 MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY

 UTERUS CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 847 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 46

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91682 GROUP 4: 175 PPM FEMALE SCHEDULED EUTH 11/26/13 DATE OF DEATH: 11/26/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.97 0.583 8,7

LIVER 14.44 4.272 ^==> GROSS UNCONFIRMED

KIDNEYS 2.42 0.716 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 1.10 0.325 9,8

LUNGS 1.46 0.432 ^==> GROSS UNCONFIRMED

OVARIES 0.1347 0.040 UTERUS MICRO: IMPLANTATION SITE P

PITUITARY 0.0146 0.004 BILATERAL

FINAL BODY WT(G) 338. NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY

 SPLEEN CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 848 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 47

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91624 GROUP 5: 10000 PPM FEMALE SCHEDULED EUTH 11/25/13 DATE OF DEATH: 11/25/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 2.03 0.632 5,12

LIVER 12.89 4.016 ^==> GROSS UNCONFIRMED

KIDNEYS 2.18 0.679 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.75 0.234 6,12

LUNGS 1.47 0.458 ^==> GROSS UNCONFIRMED

OVARIES 0.1124 0.035 MAMMARY GLAND MICRO: INFLAMMATION, SUPPURATIVE 2

PITUITARY 0.0161 0.005 UTERUS MICRO: IMPLANTATION SITE P

FINAL BODY WT(G) 321. BILATERAL

 NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:LUNGS OVARIES PITUITARY SPLEEN

 CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 849 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 48

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91625 GROUP 5: 10000 PPM FEMALE SCHEDULED EUTH 11/26/13 DATE OF DEATH: 11/26/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.85 0.631 7,7

LIVER 12.81 4.372 ^==> GROSS UNCONFIRMED

KIDNEYS 1.74 0.594 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.56 0.191 8,8

LUNGS 1.20 0.410 ^==> GROSS UNCONFIRMED

OVARIES 0.1289 0.044 UTERUS MICRO: IMPLANTATION SITE P

PITUITARY 0.0199 0.007 BILATERAL

FINAL BODY WT(G) 293. NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY

 SPLEEN CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 850 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 49

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91627 GROUP 5: 10000 PPM FEMALE SCHEDULED EUTH 11/23/13 DATE OF DEATH: 11/23/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.92 0.634 3,9

LIVER 12.77 4.215 ^==> GROSS UNCONFIRMED

KIDNEYS 2.27 0.749 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.68 0.224 3,9

LUNGS 1.42 0.469 ^==> GROSS UNCONFIRMED

OVARIES 0.1083 0.036 LUNGS MICRO: ATELECTASIS 3

PITUITARY 0.0189 0.006 UTERUS MICRO: IMPLANTATION SITE P

FINAL BODY WT(G) 303. BILATERAL

 NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:MAMMARY GLAND OVARIES PITUITARY SPLEEN

 CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 851 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 50

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91634 GROUP 5: 10000 PPM FEMALE SCHEDULED EUTH 11/26/13 DATE OF DEATH: 11/26/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.95 0.589 6,9

LIVER 13.39 4.045 ^==> GROSS UNCONFIRMED

KIDNEYS 2.60 0.785 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.64 0.193 6,11

LUNGS 1.42 0.429 ^==> GROSS UNCONFIRMED

OVARIES 0.1248 0.038 LUNGS MICRO: ATELECTASIS 2

PITUITARY 0.0169 0.005 POST-TERMINAL

FINAL BODY WT(G) 331. UTERUS MICRO: IMPLANTATION SITE P

 BILATERAL

 NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:MAMMARY GLAND OVARIES PITUITARY SPLEEN

 CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 852 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 51

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91635 GROUP 5: 10000 PPM FEMALE SCHEDULED EUTH 11/23/13 DATE OF DEATH: 11/23/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 2.13 0.630 8,6

LIVER 14.56 4.308 ^==> GROSS UNCONFIRMED

KIDNEYS 2.11 0.624 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.73 0.216 8,7

LUNGS 1.53 0.453 ^==> GROSS UNCONFIRMED

OVARIES 0.1147 0.034 OVARIES MICRO: NO SIGNIFICANT CHANGES OBSERVED

PITUITARY 0.0193 0.006 MINIMAL TISSUE OTHER THAN CORPORA LUTEA

FINAL BODY WT(G) 338. UTERUS MICRO: IMPLANTATION SITE P

 BILATERAL

 NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY

 SPLEEN CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 853 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 52

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91638 GROUP 5: 10000 PPM FEMALE SCHEDULED EUTH 11/25/13 DATE OF DEATH: 11/25/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 2.06 0.646 4,12

LIVER 11.86 3.718 ^==> GROSS UNCONFIRMED

KIDNEYS 1.95 0.611 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.57 0.179 5,12

LUNGS 1.43 0.448 ^==> GROSS UNCONFIRMED

OVARIES 0.1067 0.033 LUNGS MICRO: MINERALIZATION, VASCULAR 1

PITUITARY 0.0169 0.005 UTERUS MICRO: IMPLANTATION SITE P

FINAL BODY WT(G) 319. UNILATERAL

 NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:MAMMARY GLAND OVARIES PITUITARY SPLEEN

 CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 854 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 53

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91652 GROUP 5: 10000 PPM FEMALE SCHEDULED EUTH 11/23/13 DATE OF DEATH: 11/23/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.94 0.546 6,8

LIVER 14.76 4.158 ^==> GROSS UNCONFIRMED

KIDNEYS 2.46 0.693 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.97 0.273 7,8

LUNGS 1.52 0.428 ^==> GROSS UNCONFIRMED

OVARIES 0.1185 0.033 LUNGS MICRO: MINERALIZATION, VASCULAR 1

PITUITARY 0.0180 0.005 UTERUS MICRO: IMPLANTATION SITE P

FINAL BODY WT(G) 355. BILATERAL

 NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:MAMMARY GLAND OVARIES PITUITARY SPLEEN

 CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 855 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 54

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91655 GROUP 5: 10000 PPM FEMALE SCHEDULED EUTH 11/23/13 DATE OF DEATH: 11/23/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.96 0.618 9,6

LIVER 14.16 4.467 ^==> GROSS UNCONFIRMED

KIDNEYS 2.57 0.811 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.91 0.287 9,6

LUNGS 1.52 0.479 ^==> GROSS UNCONFIRMED

OVARIES 0.1034 0.033 UTERUS MICRO: IMPLANTATION SITE P

PITUITARY 0.0141 0.004 BILATERAL

FINAL BODY WT(G) 317. NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY

 SPLEEN CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 856 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 55

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91658 GROUP 5: 10000 PPM FEMALE SCHEDULED EUTH 11/24/13 DATE OF DEATH: 11/24/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

BRAIN 1.96 0.603 7,8

LIVER 13.86 4.265 ^==> GROSS UNCONFIRMED

KIDNEYS 2.17 0.668 GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

SPLEEN 0.63 0.194 7,8

LUNGS 1.28 0.394 ^==> GROSS UNCONFIRMED

OVARIES 0.0901 0.028 UTERUS MICRO: IMPLANTATION SITE P

PITUITARY 0.0161 0.005 BILATERAL

FINAL BODY WT(G) 325. NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY

 SPLEEN CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 857 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 56

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91667 GROUP 5: 10000 PPM FEMALE SCHEDULED EUTH 11/24/13 DATE OF DEATH: 11/24/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.89 0.543 6,10

LIVER 14.53 4.175 ^==> GROSS UNCONFIRMED

KIDNEYS 2.31 0.664 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.60 0.172 9,11

LUNGS 1.33 0.382 ^==> GROSS UNCONFIRMED

OVARIES 0.1316 0.038 UTERUS MICRO: IMPLANTATION SITE P

PITUITARY 0.0192 0.006 BILATERAL

FINAL BODY WT(G) 348. NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY

 SPLEEN CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 858 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 57

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91668 GROUP 5: 10000 PPM FEMALE SCHEDULED EUTH 11/24/13 DATE OF DEATH: 11/24/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 2.06 0.602 5,10

LIVER 14.59 4.266 ^==> GROSS UNCONFIRMED

KIDNEYS 2.65 0.775 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 1.31 0.383 5,12

LUNGS 1.60 0.468 ^==> GROSS UNCONFIRMED

OVARIES 0.1886 0.055 SPLEEN MICRO: HEMATOPOIESIS, EXTRAMEDULLARY, INCREASED 2

PITUITARY 0.0161 0.005 UTERUS MICRO: IMPLANTATION SITE P

FINAL BODY WT(G) 342. BILATERAL

 NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:LUNGS MAMMARY GLAND OVARIES PITUITARY

 CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

Page 859 of 1107
 TABLE A42 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 58

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS

ANIMAL NO. 91680 GROUP 5: 10000 PPM FEMALE SCHEDULED EUTH 11/23/13 DATE OF DEATH: 11/23/13

 GRADE

-----------------------------------------------------------------------------------------------------------------------------------

ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P

BRAIN 1.93 0.594 8,7

LIVER 13.70 4.215 ^==> GROSS UNCONFIRMED

KIDNEYS 2.00 0.615 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P

SPLEEN 0.56 0.172 8,7

LUNGS 1.54 0.474 ^==> GROSS UNCONFIRMED

OVARIES 0.1366 0.042 LUNGS MICRO: MINERALIZATION, VASCULAR 2

PITUITARY 0.0190 0.006 PITUITARY MICRO: NO SIGNIFICANT CHANGES OBSERVED

FINAL BODY WT(G) 325. PARS DISTALIS ONLY

 SPLEEN MICRO: NO SIGNIFICANT CHANGES OBSERVED

 NORMAL, BUT LARGE ON SUBGROSS

 UTERUS MICRO: IMPLANTATION SITE P

 BILATERAL

 NO SIGNIFICANT

 CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES

 HEART INTESTINE KIDNEYS LIVER

 LN, MESENTERIC LUNGS MAMMARY GLAND OVIDUCTS

 OVARIES PANCREAS PITUITARY SPINAL CORD

 SAL. GLAND MAND SKIN SPLEEN STOMACH

 THYMUS THYROID GLANDS TRACHEA URINARY BLADDER

 UTERUS CERVIX VAGINA DIAPHRAGM

 MICRO:MAMMARY GLAND OVARIES PITUITARY SPLEEN

 CERVIX VAGINA

 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-SEVERE, P-PRESENT

 MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

 ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

 PGRHv4.68

 02/18/2014

Page 860 of 1107
 TABLE A43 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CORPORA LUTEA AND IMPLANTATION SITES

 0 PPM

 DAM IMPLANTATION PUPS UNACCOUNTED CORPORA

 NO. SITES BORN SITES LUTEA

-----------------------------------------------------------------------------------------------------------------------------------

 91629 16 16 0 16

 91630 16 14 2 16

 91633 16 15 1 17

 91637 15 13 2 15

 91639 17 10 7 20

 91644 18 17 1 18

 91645 16 16 0 16

 91648 14 14 0 15

 91653 17 15 2 17

 91660 15 14 1 18

 91670 14 14 0 14

 91672 16 14 2 16

-----------------------------------------------------------------------------------------------------------------------------------

 MEAN 15.8 14.3 1.5 16.5

 S.D. 1.19 1.78 1.93 1.62

 S.E. 0.34 0.51 0.56 0.47

 N 12 12 12 12

NOTE: ONLY DAMS THAT HAVE DELIVERED ONE OR MORE PUPS ARE INCLUDED IN CALCULATION OF MEAN.

Page 861 of 1107
 TABLE A43 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CORPORA LUTEA AND IMPLANTATION SITES

 50 PPM

 DAM IMPLANTATION PUPS UNACCOUNTED CORPORA

 NO. SITES BORN SITES LUTEA

-----------------------------------------------------------------------------------------------------------------------------------

 91632 15 15 0 16

 91640 14 12 2 17

 91642 15 15 0 16

 91647 13 13 0 13

 91651 14 12 2 14

 91659 14 13 1 14

 91661 17 17 0 17

 91663 15 15 0 15

 91669 16 16 0 16

 91673 16 16 0 16

 91683 13 12 1 14

 91685 10 10 0 16

-----------------------------------------------------------------------------------------------------------------------------------

 MEAN 14.3 13.8 0.5 15.3

 S.D. 1.83 2.12 0.80 1.30

 S.E. 0.53 0.61 0.23 0.38

 N 12 12 12 12

NOTE: ONLY DAMS THAT HAVE DELIVERED ONE OR MORE PUPS ARE INCLUDED IN CALCULATION OF MEAN.

Page 862 of 1107
 TABLE A43 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CORPORA LUTEA AND IMPLANTATION SITES

 100 PPM

 DAM IMPLANTATION PUPS UNACCOUNTED CORPORA

 NO. SITES BORN SITES LUTEA

-----------------------------------------------------------------------------------------------------------------------------------

 91620 15 14 1 15

 91628 15 15 0 15

 91631 15 15 0 19

 91636 16 13 3 16

 91649 16 16 0 16

 91650 14 14 0 15

 91656 16 15 1 17

 91671 15 15 0 15

 91675 14 14 0 14

 91677 6 5 1 16

 91679 15 12 3 15

 91684 16 16 0 16

-----------------------------------------------------------------------------------------------------------------------------------

 MEAN 14.4 13.7 0.8 15.8

 S.D. 2.75 2.96 1.14 1.29

 S.E. 0.79 0.86 0.33 0.37

 N 12 12 12 12

NOTE: ONLY DAMS THAT HAVE DELIVERED ONE OR MORE PUPS ARE INCLUDED IN CALCULATION OF MEAN.

Page 863 of 1107
 TABLE A43 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CORPORA LUTEA AND IMPLANTATION SITES

 175 PPM

 DAM IMPLANTATION PUPS UNACCOUNTED CORPORA

 NO. SITES BORN SITES LUTEA

-----------------------------------------------------------------------------------------------------------------------------------

 91622 15 14 1 15

 91626 15 14 1 15

 91643 15 12 3 18

 91654 19 18 1 19

 91657 16 13 3 17

 91662 15 11 4 18

 91666 12 11 1 13

 91676 14 11 3 14

 91678 17 14 3 17

 91681 15 15 0 15

 91682 15 13 2 17

-----------------------------------------------------------------------------------------------------------------------------------

 MEAN 15.3 13.3 2.0 16.2

 S.D. 1.74 2.10 1.26 1.89

 S.E. 0.52 0.63 0.38 0.57

 N 11 11 11 11

NOTE: ONLY DAMS THAT HAVE DELIVERED ONE OR MORE PUPS ARE INCLUDED IN CALCULATION OF MEAN.

Page 864 of 1107
 TABLE A43 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL CORPORA LUTEA AND IMPLANTATION SITES

 10000 PPM

 DAM IMPLANTATION PUPS UNACCOUNTED CORPORA

 NO. SITES BORN SITES LUTEA

-----------------------------------------------------------------------------------------------------------------------------------

 91624 17 13 4 18

 91625 14 14 0 16

 91627 12-A 13 A 12-A

 91634 15 13 2 17

 91635 14 13 1 15

 91638 16 16 0 17

 91652 14 13 1 15

 91655 15 13 2 15

 91658 15 13 2 15

 91667 16 16 0 20

 91668 15 15 0 17

 91680 15 15 0 15

-----------------------------------------------------------------------------------------------------------------------------------

 MEAN 15.1 13.9 1.1 16.4

 S.D. 0.94 1.24 1.30 1.63

 S.E. 0.28 0.36 0.39 0.49

 N 11 12 11 11

NOTE: ONLY DAMS THAT HAVE DELIVERED ONE OR MORE PUPS ARE INCLUDED IN CALCULATION OF MEAN.

A = NUMBER OF PUPS BORN EXCEEDED NUMBER OF IMPLANTATION SITES; VALUE NOT INCLUDED IN CALCULATION OF MEAN

 PIISv4.12

 01/07/2014

 R:01/21/2014

Page 865 of 1107
 TABLE A44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]

 MALE GROUP: 0 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 TESTI

 ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS S, RT

-----------------------------------------------------------------------------------------------------------------------------------

 91555 460. 2.16 14.72 3.45 0.85 1.62 1.50

 91560 458. 2.23 15.81 3.54 0.87 1.88 1.70

 91562 430. 2.05 16.66 3.28 0.82 1.40 1.62

 91563 414. 2.08 14.49 3.32 0.70 1.68 1.67

 91564 424. 2.10 14.20 3.56 0.66 1.65 1.68

 91567 411. 1.86 15.57 3.23 0.74 1.41 1.59

 91579 468. 2.17 17.75 3.26 0.90 1.78 1.66

 91586 458. 2.12 16.47 3.42 0.94 1.75 1.63

 91591 456. 2.11 14.86 3.35 0.77 1.75 1.69

 91592 507. 2.28 17.30 3.44 1.06 1.86 1.79

 91609 442. 2.16 15.38 3.52 0.71 1.44 1.86

 91615 469. 2.15 16.54 3.26 0.79 1.68 1.63

MEAN 450. 2.12 15.81 3.39 0.82 1.66 1.67

S.D. 27.2 0.104 1.142 0.118 0.114 0.165 0.092

S.E. 7.9 0.030 0.330 0.034 0.033 0.048 0.027

 N 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT

Page 866 of 1107
 TABLE A44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]

 MALE GROUP: 50 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 TESTI

 ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS S, RT

-----------------------------------------------------------------------------------------------------------------------------------

 91556 447. 1.94 14.68 3.07 0.67 1.57 1.68

 91559 428. 1.95 16.22 3.46 0.85 1.89 1.77

 91561 455. 2.09 16.27 3.46 0.86 1.80 1.68

 91566 428. 1.87 14.61 3.24 0.72 1.48 1.71

 91576 413. 2.09 14.82 3.37 0.79 1.42 1.66

 91582 513. 2.14 18.93 3.94 1.01 1.70 1.94

 91585 500. 2.04 21.23 3.98 1.04 1.79 1.67

 91589 416. 2.02 13.44 2.92 0.69 1.72 1.60

 91593 456. 2.17 16.35 3.49 0.96 1.63 1.41

 91594 452. 2.07 16.00 2.98 0.74 2.02 1.67

 91595 478. 2.19 17.08 3.04 0.92 1.82 1.66

 91602 482. 1.89 16.87 3.65 0.79 1.70 1.80

MEAN 456. 2.04 16.38 3.38 0.84 1.71 1.69

S.D. 32.3 0.107 2.090 0.353 0.125 0.170 0.125

S.E. 9.3 0.031 0.603 0.102 0.036 0.049 0.036

 N 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT

Page 867 of 1107
 TABLE A44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]

 MALE GROUP: 100 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 TESTI

 ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS S, RT

-----------------------------------------------------------------------------------------------------------------------------------

 91569 430. 2.06 14.10 2.81 0.89 1.60 1.61

 91573 414. 2.16 15.39 3.27 0.75 1.47 1.86

 91577 409. 2.02 14.70 3.19 0.68 1.84 1.55

 91581 439. 2.07 15.67 3.32 0.72 1.78 1.63

 91583 407. 2.02 14.21 2.97 0.75 1.71 1.75

 91588 453. 1.99 17.58 3.60 0.71 1.66 1.85

 91590 448. 2.18 15.06 3.15 0.80 1.61 1.54

 91598 412. 1.97 14.00 3.45 0.74 1.74 1.54

 91599 416. 2.02 15.92 3.13 0.77 1.64 1.52

 91608 445. 2.03 14.49 3.35 0.79 1.80 1.75

 91611 441. 1.95 15.63 3.35 0.74 1.67 1.70

 91616 454. 2.07 16.80 3.33 0.78 1.74 1.76

MEAN 431. 2.05 15.30 3.24 0.76 1.69 1.67

S.D. 18.1 0.069 1.107 0.212 0.053 0.102 0.123

S.E. 5.2 0.020 0.320 0.061 0.015 0.029 0.035

 N 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT

Page 868 of 1107
 TABLE A44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]

 MALE GROUP: 175 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 TESTI

 ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS S, RT

-----------------------------------------------------------------------------------------------------------------------------------

 91565 408. 2.06 14.18 2.94 0.68 1.67 1.47

 91568 439. 1.99 16.32 3.81 0.68 1.70 1.63

 91570 425. 1.91 14.48 3.20 0.86 1.67 1.64

 91572 427. 2.09 16.20 3.26 0.83 1.91 1.71

 91580 414. 2.00 14.26 3.32 0.60 1.87 1.71

 91584 427. 2.02 15.90 3.19 0.73 1.73 1.74

 91587 472. 2.03 17.64 3.65 0.99 2.01 1.90

 91597 425. 1.91 14.18 3.31 0.77 2.01 1.74

 91601 430. 2.04 15.22 3.32 0.84 1.61 1.62

 91607 468. 2.17 16.16 3.16 0.86 1.85 1.79

 91613 451. 1.99 15.45 3.22 0.77 2.01 1.56

 91614 464. 1.97 16.89 3.74 0.67 1.57 1.71

MEAN 438. 2.02 15.57 3.34 0.77 1.80 1.69

S.D. 21.4 0.073 1.142 0.258 0.109 0.162 0.111

S.E. 6.2 0.021 0.330 0.075 0.031 0.047 0.032

 N 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT

Page 869 of 1107
 TABLE A44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]

 MALE GROUP: 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 TESTI

 ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS S, RT

-----------------------------------------------------------------------------------------------------------------------------------

 91554 413. 1.97 12.74 2.51 0.74 1.53 1.62

 91557 459. 2.15 14.88 3.30 0.95 1.91 1.87

 91558 423. 1.94 13.27 2.95 0.66 1.71 1.62

 91571 381. 1.97 13.50 3.14 0.64 1.61 1.50

 91575 443. 2.18 14.35 3.44 0.74 1.85 1.60

 91600 448. 2.13 15.48 3.24 0.78 1.63 1.85

 91603 412. 1.93 18.11 3.60 0.70 1.72 1.74

 91604 432. 1.89 15.12 3.14 0.70 1.64 1.75

 91605 400. 2.00 13.23 2.96 0.65 1.41 1.83

 91612 388. 2.16 14.21 3.12 0.69 1.39 1.90

 91618 409. 2.17 14.65 3.35 0.83 1.62 1.59

 91619 410. 2.05 13.77 3.24 0.74 1.68 1.61

MEAN 418. 2.05 14.44 3.17 0.74 1.64 1.71

S.D. 23.8 0.107 1.426 0.278 0.087 0.153 0.133

S.E. 6.9 0.031 0.412 0.080 0.025 0.044 0.038

 N 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT

Page 870 of 1107
 TABLE A44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]

 MALE GROUP: 0 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 TESTI EPIDIDY CAUDA E PITU EPIDIDY CAUDA E

 ANIMAL S, LT MIS, LT PID, LT ITARY MIS, RT PID, RT

-----------------------------------------------------------------------------------------------------------------------------------

 91555 1.52 0.58 0.2512 0.0178 0.59 0.2510

 91560 1.69 0.60 0.2944 0.0149 0.64 0.2717

 91562 1.56 0.57 0.2560 0.0133 0.62 0.2690

 91563 1.65 0.55 0.2791 0.0142 0.64 0.2878

 91564 1.64 0.56 0.2773 0.0178 0.62 0.2677

 91567 1.59 0.55 0.2696 0.0102 0.62 0.2710

 91579 1.66 0.63 0.2849 0.0179 0.61 0.2482

 91586 1.61 0.57 0.2795 0.0227 0.67 0.2952

 91591 1.70 0.55 0.2775 0.0136 0.60 0.2654

 91592 1.76 0.63 0.3003 0.0148 0.67 0.2779

 91609 1.78 0.69 0.3171 0.0145 0.72 0.3076

 91615 1.64 0.60 0.3024 0.0159 0.66 0.2768

MEAN 1.65 0.59 0.2824 0.0156 0.64 0.2741

S.D. 0.076 0.043 0.01902 0.00314 0.037 0.01689

S.E. 0.022 0.012 0.00549 0.00091 0.011 0.00488

 N 12 12 12 12 12 12

Page 871 of 1107
 TABLE A44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]

 MALE GROUP: 50 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 TESTI EPIDIDY CAUDA E PITU EPIDIDY CAUDA E

 ANIMAL S, LT MIS, LT PID, LT ITARY MIS, RT PID, RT

-----------------------------------------------------------------------------------------------------------------------------------

 91556 1.67 0.64 0.2826 0.0126 0.68 0.2840

 91559 1.79 0.59 0.2970 0.0143 0.62 0.2438

 91561 1.61 0.68 0.3222 0.0176 0.69 0.3183

 91566 1.73 0.61 0.2596 0.0120 0.67 0.2544

 91576 1.67 0.60 0.2934 0.0134 0.64 0.3055

 91582 1.90 0.64 0.3067 0.0162 0.70 0.2774

 91585 1.72 0.67 0.2929 0.0174 0.69 0.2850

 91589 1.53 0.54 0.2590 0.0129 0.57 0.2568

 91593 1.47 0.55 0.2649 0.0165 0.61 0.2732

 91594 1.62 0.58 0.3126 0.0153 0.60 0.2789

 91595 1.70 0.67 0.3439 0.0146 0.71 0.3060

 91602 1.81 0.62 0.3050 0.0120 0.65 0.3072

MEAN 1.69 0.62 0.2950 0.0146 0.65 0.2825

S.D. 0.119 0.046 0.02576 0.00203 0.045 0.02346

S.E. 0.034 0.013 0.00744 0.00059 0.013 0.00677

 N 12 12 12 12 12 12

Page 872 of 1107
 TABLE A44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]

 MALE GROUP: 100 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 TESTI EPIDIDY CAUDA E PITU EPIDIDY CAUDA E

 ANIMAL S, LT MIS, LT PID, LT ITARY MIS, RT PID, RT

-----------------------------------------------------------------------------------------------------------------------------------

 91569 1.48 0.54 0.2398 0.0103 0.56 0.2163

 91573 1.86 0.65 0.2993 0.0134 0.73 0.3138

 91577 1.57 0.53 0.2611 0.0105 0.57 0.2454

 91581 1.59 0.59 0.3040 0.0125 0.64 0.2767

 91583 1.74 0.61 0.2789 0.0119 0.66 0.2743

 91588 1.85 0.63 0.2997 0.0125 0.64 0.3015

 91590 1.55 0.57 0.2844 0.0151 0.63 0.2792

 91598 1.55 0.57 0.2715 0.0136 0.59 0.2539

 91599 1.52 0.56 0.2566 0.0123 0.60 0.2632

 91608 1.76 0.57 0.2618 0.0117 0.64 0.2603

 91611 1.68 0.66 0.3093 0.0130 0.66 0.2551

 91616 1.81 0.58 0.2749 0.0141 0.66 0.2745

MEAN 1.66 0.59 0.2784 0.0126 0.63 0.2679

S.D. 0.136 0.041 0.02161 0.00139 0.047 0.02547

S.E. 0.039 0.012 0.00624 0.00040 0.013 0.00735

 N 12 12 12 12 12 12

Page 873 of 1107
 TABLE A44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]

 MALE GROUP: 175 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 TESTI EPIDIDY CAUDA E PITU EPIDIDY CAUDA E

 ANIMAL S, LT MIS, LT PID, LT ITARY MIS, RT PID, RT

-----------------------------------------------------------------------------------------------------------------------------------

 91565 1.41 0.53 0.2525 0.0106 0.59 0.2524

 91568 1.60 0.62 0.2921 0.0140 0.62 0.2490

 91570 1.68 0.61 0.2583 0.0124 0.64 0.2848

 91572 1.65 0.60 0.2723 0.0121 0.63 0.2798

 91580 1.72 0.58 0.2866 0.0126 0.56 0.2404

 91584 1.74 0.66 0.2757 0.0138 0.62 0.2533

 91587 1.87 0.66 0.3195 0.0135 0.66 0.2723

 91597 1.75 0.59 0.2668 0.0113 0.66 0.2745

 91601 1.59 0.60 0.2826 0.0119 0.62 0.2693

 91607 1.69 0.62 0.2889 0.0132 0.71 0.2990

 91613 1.56 0.56 0.2233 0.0144 0.61 0.2292

 91614 1.65 0.68 0.3280 0.0128 0.71 0.3102

MEAN 1.66 0.61 0.2789 0.0127 0.64 0.2679

S.D. 0.115 0.043 0.02832 0.00113 0.044 0.02396

S.E. 0.033 0.012 0.00817 0.00033 0.013 0.00692

 N 12 12 12 12 12 12

Page 874 of 1107
 TABLE A44 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]

 MALE GROUP: 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 TESTI EPIDIDY CAUDA E PITU EPIDIDY CAUDA E

 ANIMAL S, LT MIS, LT PID, LT ITARY MIS, RT PID, RT

-----------------------------------------------------------------------------------------------------------------------------------

 91554 1.52 0.63 0.2980 0.0130 0.57 0.2265

 91557 1.88 0.62 0.2711 0.0159 0.66 0.2960

 91558 1.58 0.55 0.2771 0.0107 0.62 0.2652

 91571 1.50 0.55 0.2693 0.0125 0.58 0.2648

 91575 1.55 0.56 0.2104 0.0122 0.59 0.2488

 91600 1.72 0.64 0.3179 0.0132 0.73 0.3173

 91603 1.73 0.66 0.2831 0.0123 0.68 0.2552

 91604 1.71 0.64 0.2876 0.0149 0.68 0.2619

 91605 1.86 0.60 0.3019 0.0127 0.61 0.2506

 91612 1.86 0.66 0.3086 0.0134 0.74 0.2796

 91618 1.55 0.58 0.2653 0.0157 0.63 0.2693

 91619 1.62 0.53 0.2584 0.0131 0.56 0.2330

MEAN 1.67 0.60 0.2791 0.0133 0.64 0.2640

S.D. 0.140 0.046 0.02835 0.00151 0.061 0.02522

S.E. 0.040 0.013 0.00819 0.00044 0.018 0.00728

 N 12 12 12 12 12 12

 POFBWv4.31

 11/25/2013

 R:01/17/2014

Page 875 of 1107
 TABLE A45 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]

 MALE GROUP: 0 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 TESTI

 ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS S, RT

-----------------------------------------------------------------------------------------------------------------------------------

 91555 460. 0.470 3.200 0.750 0.185 0.352 0.326

 91560 458. 0.487 3.452 0.773 0.190 0.410 0.371

 91562 430. 0.477 3.874 0.763 0.191 0.326 0.377

 91563 414. 0.502 3.500 0.802 0.169 0.406 0.403

 91564 424. 0.495 3.349 0.840 0.156 0.389 0.396

 91567 411. 0.453 3.788 0.786 0.180 0.343 0.387

 91579 468. 0.464 3.793 0.697 0.192 0.380 0.355

 91586 458. 0.463 3.596 0.747 0.205 0.382 0.356

 91591 456. 0.463 3.259 0.735 0.169 0.384 0.371

 91592 507. 0.450 3.412 0.679 0.209 0.367 0.353

 91609 442. 0.489 3.480 0.796 0.161 0.326 0.421

 91615 469. 0.458 3.527 0.695 0.168 0.358 0.348

MEAN 450. 0.472 3.519 0.755 0.181 0.369 0.372

S.D. 27.2 0.0173 0.2123 0.0484 0.0170 0.0283 0.0267

S.E. 7.9 0.0050 0.0613 0.0140 0.0049 0.0082 0.0077

 N 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT

Page 876 of 1107
 TABLE A45 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]

 MALE GROUP: 50 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 TESTI

 ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS S, RT

-----------------------------------------------------------------------------------------------------------------------------------

 91556 447. 0.434 3.284 0.687 0.150 0.351 0.376

 91559 428. 0.456 3.790 0.808 0.199 0.442 0.414

 91561 455. 0.459 3.576 0.760 0.189 0.396 0.369

 91566 428. 0.437 3.414 0.757 0.168 0.346 0.400

 91576 413. 0.506 3.588 0.816 0.191 0.344 0.402

 91582 513. 0.417 3.690 0.768 0.197 0.331 0.378

 91585 500. 0.408 4.246 0.796 0.208 0.358 0.334

 91589 416. 0.486 3.231 0.702 0.166 0.413 0.385

 91593 456. 0.476 3.586 0.765 0.211 0.357 0.309

 91594 452. 0.458 3.540 0.659 0.164 0.447 0.369

 91595 478. 0.458 3.573 0.636 0.192 0.381 0.347

 91602 482. 0.392 3.500 0.757 0.164 0.353 0.373

MEAN 456. 0.449 3.585 0.743 0.183 0.377 0.371

S.D. 32.3 0.0329 0.2602 0.0584 0.0199 0.0392 0.0295

S.E. 9.3 0.0095 0.0751 0.0169 0.0057 0.0113 0.0085

 N 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT

Page 877 of 1107
 TABLE A45 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]

 MALE GROUP: 100 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 TESTI

 ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS S, RT

-----------------------------------------------------------------------------------------------------------------------------------

 91569 430. 0.479 3.279 0.653 0.207 0.372 0.374

 91573 414. 0.522 3.717 0.790 0.181 0.355 0.449

 91577 409. 0.494 3.594 0.780 0.166 0.450 0.379

 91581 439. 0.472 3.569 0.756 0.164 0.405 0.371

 91583 407. 0.496 3.491 0.730 0.184 0.420 0.430

 91588 453. 0.439 3.881 0.795 0.157 0.366 0.408

 91590 448. 0.487 3.362 0.703 0.179 0.359 0.344

 91598 412. 0.478 3.398 0.837 0.180 0.422 0.374

 91599 416. 0.486 3.827 0.752 0.185 0.394 0.365

 91608 445. 0.456 3.256 0.753 0.178 0.404 0.393

 91611 441. 0.442 3.544 0.760 0.168 0.379 0.385

 91616 454. 0.456 3.700 0.733 0.172 0.383 0.388

MEAN 431. 0.476 3.552 0.754 0.177 0.393 0.388

S.D. 18.1 0.0240 0.2047 0.0470 0.0130 0.0288 0.0289

S.E. 5.2 0.0069 0.0591 0.0136 0.0037 0.0083 0.0083

 N 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT

Page 878 of 1107
 TABLE A45 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]

 MALE GROUP: 175 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 TESTI

 ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS S, RT

-----------------------------------------------------------------------------------------------------------------------------------

 91565 408. 0.505 3.475 0.721 0.167 0.409 0.360

 91568 439. 0.453 3.718 0.868 0.155 0.387 0.371

 91570 425. 0.449 3.407 0.753 0.202 0.393 0.386

 91572 427. 0.489 3.794 0.763 0.194 0.447 0.400

 91580 414. 0.483 3.444 0.802 0.145 0.452 0.413

 91584 427. 0.473 3.724 0.747 0.171 0.405 0.407

 91587 472. 0.430 3.737 0.773 0.210 0.426 0.403

 91597 425. 0.449 3.336 0.779 0.181 0.473 0.409

 91601 430. 0.474 3.540 0.772 0.195 0.374 0.377

 91607 468. 0.464 3.453 0.675 0.184 0.395 0.382

 91613 451. 0.441 3.426 0.714 0.171 0.446 0.346

 91614 464. 0.425 3.640 0.806 0.144 0.338 0.369

MEAN 438. 0.461 3.558 0.764 0.177 0.412 0.385

S.D. 21.4 0.0244 0.1560 0.0496 0.0217 0.0381 0.0215

S.E. 6.2 0.0070 0.0450 0.0143 0.0063 0.0110 0.0062

 N 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT

Page 879 of 1107
 TABLE A45 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]

 MALE GROUP: 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 TESTI

 ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS S, RT

-----------------------------------------------------------------------------------------------------------------------------------

 91554 413. 0.477 3.085 0.608 0.179 0.370 0.392

 91557 459. 0.468 3.242 0.719 0.207 0.416 0.407

 91558 423. 0.459 3.137 0.697 0.156 0.404 0.383

 91571 381. 0.517 3.543 0.824 0.168 0.423 0.394

 91575 443. 0.492 3.239 0.777 0.167 0.418 0.361

 91600 448. 0.475 3.455 0.723 0.174 0.364 0.413

 91603 412. 0.468 4.396 0.874 0.170 0.417 0.422

 91604 432. 0.438 3.500 0.727 0.162 0.380 0.405

 91605 400. 0.500 3.307 0.740 0.162 0.352 0.458

 91612 388. 0.557 3.662 0.804 0.178 0.358 0.490

 91618 409. 0.531 3.582 0.819 0.203 0.396 0.389

 91619 410. 0.500 3.359 0.790 0.180 0.410 0.393

MEAN 418. 0.490 3.459 0.759 0.176 0.392 0.409

S.D. 23.8 0.0331 0.3457 0.0709 0.0156 0.0260 0.0347

S.E. 6.9 0.0096 0.0998 0.0205 0.0045 0.0075 0.0100

 N 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT

Page 880 of 1107
 TABLE A45 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]

 MALE GROUP: 0 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 TESTI EPIDIDY CAUDA E PITU EPIDIDY CAUDA E

 ANIMAL S, LT MIS, LT PID, LT ITARY MIS, RT PID, RT

-----------------------------------------------------------------------------------------------------------------------------------

 91555 0.330 0.126 0.055 0.004 0.128 0.055

 91560 0.369 0.131 0.064 0.003 0.140 0.059

 91562 0.363 0.133 0.060 0.003 0.144 0.063

 91563 0.399 0.133 0.067 0.003 0.155 0.070

 91564 0.387 0.132 0.065 0.004 0.146 0.063

 91567 0.387 0.134 0.066 0.002 0.151 0.066

 91579 0.355 0.135 0.061 0.004 0.130 0.053

 91586 0.352 0.124 0.061 0.005 0.146 0.064

 91591 0.373 0.121 0.061 0.003 0.132 0.058

 91592 0.347 0.124 0.059 0.003 0.132 0.055

 91609 0.403 0.156 0.072 0.003 0.163 0.070

 91615 0.350 0.128 0.064 0.003 0.141 0.059

MEAN 0.368 0.131 0.063 0.003 0.142 0.061

S.D. 0.0224 0.0090 0.0045 0.0007 0.0107 0.0057

S.E. 0.0065 0.0026 0.0013 0.0002 0.0031 0.0016

 N 12 12 12 12 12 12

Page 881 of 1107
 TABLE A45 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]

 MALE GROUP: 50 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 TESTI EPIDIDY CAUDA E PITU EPIDIDY CAUDA E

 ANIMAL S, LT MIS, LT PID, LT ITARY MIS, RT PID, RT

-----------------------------------------------------------------------------------------------------------------------------------

 91556 0.374 0.143 0.063 0.003 0.152 0.064

 91559 0.418 0.138 0.069 0.003 0.145 0.057

 91561 0.354 0.149 0.071 0.004 0.152 0.070

 91566 0.404 0.143 0.061 0.003 0.157 0.059

 91576 0.404 0.145 0.071 0.003 0.155 0.074

 91582 0.370 0.125 0.060 0.003 0.136 0.054

 91585 0.344 0.134 0.059 0.003 0.138 0.057

 91589 0.368 0.130 0.062 0.003 0.137 0.062

 91593 0.322 0.121 0.058 0.004 0.134 0.060

 91594 0.358 0.128 0.069 0.003 0.133 0.062

 91595 0.356 0.140 0.072 0.003 0.149 0.064

 91602 0.376 0.129 0.063 0.002 0.135 0.064

MEAN 0.371 0.135 0.065 0.003 0.143 0.062

S.D. 0.0274 0.0090 0.0053 0.0004 0.0089 0.0056

S.E. 0.0079 0.0026 0.0015 0.0001 0.0026 0.0016

 N 12 12 12 12 12 12

Page 882 of 1107
 TABLE A45 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]

 MALE GROUP: 100 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 TESTI EPIDIDY CAUDA E PITU EPIDIDY CAUDA E

 ANIMAL S, LT MIS, LT PID, LT ITARY MIS, RT PID, RT

-----------------------------------------------------------------------------------------------------------------------------------

 91569 0.344 0.126 0.056 0.002 0.130 0.050

 91573 0.449 0.157 0.072 0.003 0.176 0.076

 91577 0.384 0.130 0.064 0.003 0.139 0.060

 91581 0.362 0.134 0.069 0.003 0.146 0.063

 91583 0.428 0.150 0.069 0.003 0.162 0.067

 91588 0.408 0.139 0.066 0.003 0.141 0.067

 91590 0.346 0.127 0.063 0.003 0.141 0.062

 91598 0.376 0.138 0.066 0.003 0.143 0.062

 91599 0.365 0.135 0.062 0.003 0.144 0.063

 91608 0.396 0.128 0.059 0.003 0.144 0.058

 91611 0.381 0.150 0.070 0.003 0.150 0.058

 91616 0.399 0.128 0.061 0.003 0.145 0.060

MEAN 0.387 0.137 0.065 0.003 0.147 0.062

S.D. 0.0315 0.0104 0.0049 0.0003 0.0119 0.0063

S.E. 0.0091 0.0030 0.0014 0.0001 0.0034 0.0018

 N 12 12 12 12 12 12

Page 883 of 1107
 TABLE A45 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]

 MALE GROUP: 175 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 TESTI EPIDIDY CAUDA E PITU EPIDIDY CAUDA E

 ANIMAL S, LT MIS, LT PID, LT ITARY MIS, RT PID, RT

-----------------------------------------------------------------------------------------------------------------------------------

 91565 0.346 0.130 0.062 0.003 0.145 0.062

 91568 0.364 0.141 0.067 0.003 0.141 0.057

 91570 0.395 0.144 0.061 0.003 0.151 0.067

 91572 0.386 0.141 0.064 0.003 0.148 0.066

 91580 0.415 0.140 0.069 0.003 0.135 0.058

 91584 0.407 0.155 0.065 0.003 0.145 0.059

 91587 0.396 0.140 0.068 0.003 0.140 0.058

 91597 0.412 0.139 0.063 0.003 0.155 0.065

 91601 0.370 0.140 0.066 0.003 0.144 0.063

 91607 0.361 0.132 0.062 0.003 0.152 0.064

 91613 0.346 0.124 0.050 0.003 0.135 0.051

 91614 0.356 0.147 0.071 0.003 0.153 0.067

MEAN 0.380 0.139 0.064 0.003 0.145 0.061

S.D. 0.0256 0.0078 0.0054 0.0002 0.0066 0.0049

S.E. 0.0074 0.0023 0.0016 0.0001 0.0019 0.0014

 N 12 12 12 12 12 12

Page 884 of 1107
 TABLE A45 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]

 MALE GROUP: 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 TESTI EPIDIDY CAUDA E PITU EPIDIDY CAUDA E

 ANIMAL S, LT MIS, LT PID, LT ITARY MIS, RT PID, RT

-----------------------------------------------------------------------------------------------------------------------------------

 91554 0.368 0.153 0.072 0.003 0.138 0.055

 91557 0.410 0.135 0.059 0.003 0.144 0.064

 91558 0.374 0.130 0.066 0.003 0.147 0.063

 91571 0.394 0.144 0.071 0.003 0.152 0.070

 91575 0.350 0.126 0.047 0.003 0.133 0.056

 91600 0.384 0.143 0.071 0.003 0.163 0.071

 91603 0.420 0.160 0.069 0.003 0.165 0.062

 91604 0.396 0.148 0.067 0.003 0.157 0.061

 91605 0.465 0.150 0.075 0.003 0.153 0.063

 91612 0.479 0.170 0.080 0.003 0.191 0.072

 91618 0.379 0.142 0.065 0.004 0.154 0.066

 91619 0.395 0.129 0.063 0.003 0.137 0.057

MEAN 0.401 0.144 0.067 0.003 0.153 0.063

S.D. 0.0382 0.0131 0.0083 0.0004 0.0157 0.0057

S.E. 0.0110 0.0038 0.0024 0.0001 0.0045 0.0016

 N 12 12 12 12 12 12

 POFBWv4.31

 11/25/2013

 R:01/17/2014

Page 885 of 1107
 TABLE A46 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G]

 MALE GROUP: 0 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 BRAIN WT TESTI

 ANIMAL FBW(G) (GRAMS) LIVER KIDNEYS SPLEEN LUNGS S, RT

-----------------------------------------------------------------------------------------------------------------------------------

 91555 460. 2.16 681.482 159.722 39.352 75.000 69.444

 91560 458. 2.23 708.969 158.744 39.013 84.305 76.233

 91562 430. 2.05 812.683 160.000 40.000 68.293 79.024

 91563 414. 2.08 696.635 159.615 33.654 80.769 80.288

 91564 424. 2.10 676.191 169.524 31.429 78.571 80.000

 91567 411. 1.86 837.097 173.656 39.785 75.806 85.484

 91579 468. 2.17 817.972 150.230 41.475 82.028 76.498

 91586 458. 2.12 776.887 161.321 44.340 82.547 76.887

 91591 456. 2.11 704.265 158.768 36.493 82.938 80.095

 91592 507. 2.28 758.772 150.877 46.491 81.579 78.509

 91609 442. 2.16 712.037 162.963 32.870 66.667 86.111

 91615 469. 2.15 769.302 151.628 36.744 78.140 75.814

MEAN 450. 2.12 746.024 159.754 38.470 78.054 78.699

S.D. 27.2 0.104 56.6688 7.0004 4.5124 5.7074 4.4258

S.E. 7.9 0.030 16.3589 2.0209 1.3026 1.6476 1.2776

 N 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT

Page 886 of 1107
 TABLE A46 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G]

 MALE GROUP: 50 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 BRAIN WT TESTI

 ANIMAL FBW(G) (GRAMS) LIVER KIDNEYS SPLEEN LUNGS S, RT

-----------------------------------------------------------------------------------------------------------------------------------

 91556 447. 1.94 756.701 158.247 34.536 80.928 86.598

 91559 428. 1.95 831.795 177.436 43.590 96.923 90.769

 91561 455. 2.09 778.469 165.550 41.148 86.124 80.383

 91566 428. 1.87 781.283 173.262 38.503 79.144 91.444

 91576 413. 2.09 709.091 161.244 37.799 67.943 79.426

 91582 513. 2.14 884.579 184.112 47.196 79.439 90.654

 91585 500. 2.04 1040.686 195.098 50.980 87.745 81.863

 91589 416. 2.02 665.347 144.554 34.158 85.149 79.208

 91593 456. 2.17 753.456 160.829 44.240 75.115 64.977

 91594 452. 2.07 772.947 143.961 35.749 97.585 80.676

 91595 478. 2.19 779.909 138.813 42.009 83.105 75.799

 91602 482. 1.89 892.593 193.122 41.799 89.947 95.238

MEAN 456. 2.04 803.905 166.352 40.976 84.096 83.086

S.D. 32.3 0.107 98.5677 18.7974 5.1303 8.5177 8.3680

S.E. 9.3 0.031 28.4540 5.4263 1.4810 2.4588 2.4156

 N 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT

Page 887 of 1107
 TABLE A46 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G]

 MALE GROUP: 100 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 BRAIN WT TESTI

 ANIMAL FBW(G) (GRAMS) LIVER KIDNEYS SPLEEN LUNGS S, RT

-----------------------------------------------------------------------------------------------------------------------------------

 91569 430. 2.06 684.466 136.408 43.204 77.670 78.155

 91573 414. 2.16 712.500 151.389 34.722 68.056 86.111

 91577 409. 2.02 727.723 157.921 33.663 91.089 76.733

 91581 439. 2.07 757.005 160.386 34.783 85.990 78.744

 91583 407. 2.02 703.465 147.030 37.129 84.653 86.634

 91588 453. 1.99 883.417 180.905 35.678 83.417 92.965

 91590 448. 2.18 690.826 144.495 36.697 73.853 70.642

 91598 412. 1.97 710.660 175.127 37.563 88.325 78.173

 91599 416. 2.02 788.119 154.951 38.119 81.188 75.248

 91608 445. 2.03 713.793 165.025 38.916 88.670 86.207

 91611 441. 1.95 801.538 171.795 37.949 85.641 87.179

 91616 454. 2.07 811.594 160.870 37.681 84.058 85.024

MEAN 431. 2.05 748.759 158.858 37.175 82.718 81.818

S.D. 18.1 0.069 60.6455 13.0893 2.4830 6.6306 6.4261

S.E. 5.2 0.020 17.5068 3.7786 0.7168 1.9141 1.8551

 N 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT

Page 888 of 1107
 TABLE A46 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G]

 MALE GROUP: 175 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 BRAIN WT TESTI

 ANIMAL FBW(G) (GRAMS) LIVER KIDNEYS SPLEEN LUNGS S, RT

-----------------------------------------------------------------------------------------------------------------------------------

 91565 408. 2.06 688.350 142.718 33.010 81.068 71.359

 91568 439. 1.99 820.101 191.457 34.171 85.427 81.910

 91570 425. 1.91 758.115 167.539 45.026 87.435 85.864

 91572 427. 2.09 775.120 155.981 39.713 91.388 81.818

 91580 414. 2.00 713.000 166.000 30.000 93.500 85.500

 91584 427. 2.02 787.129 157.921 36.139 85.644 86.139

 91587 472. 2.03 868.966 179.803 48.768 99.015 93.596

 91597 425. 1.91 742.408 173.298 40.314 105.236 91.099

 91601 430. 2.04 746.078 162.745 41.176 78.922 79.412

 91607 468. 2.17 744.700 145.622 39.631 85.253 82.488

 91613 451. 1.99 776.382 161.809 38.693 101.005 78.392

 91614 464. 1.97 857.360 189.848 34.010 79.695 86.802

MEAN 438. 2.02 773.142 166.229 38.388 89.466 83.698

S.D. 21.4 0.073 54.1115 15.4138 5.2915 8.6495 5.9026

S.E. 6.2 0.021 15.6206 4.4496 1.5275 2.4969 1.7039

 N 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT

Page 889 of 1107
 TABLE A46 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G]

 MALE GROUP: 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 BRAIN WT TESTI

 ANIMAL FBW(G) (GRAMS) LIVER KIDNEYS SPLEEN LUNGS S, RT

-----------------------------------------------------------------------------------------------------------------------------------

 91554 413. 1.97 646.701 127.411 37.563 77.665 82.234

 91557 459. 2.15 692.093 153.488 44.186 88.837 86.977

 91558 423. 1.94 684.021 152.062 34.021 88.144 83.505

 91571 381. 1.97 685.279 159.391 32.487 81.726 76.142

 91575 443. 2.18 658.257 157.798 33.945 84.862 73.394

 91600 448. 2.13 726.760 152.113 36.620 76.526 86.854

 91603 412. 1.93 938.342 186.529 36.269 89.119 90.155

 91604 432. 1.89 800.000 166.138 37.037 86.772 92.593

 91605 400. 2.00 661.500 148.000 32.500 70.500 91.500

 91612 388. 2.16 657.870 144.444 31.944 64.352 87.963

 91618 409. 2.17 675.115 154.378 38.249 74.654 73.272

 91619 410. 2.05 671.707 158.049 36.098 81.951 78.537

MEAN 418. 2.05 708.137 154.983 35.910 80.426 83.594

S.D. 23.8 0.107 83.4066 13.8028 3.3728 7.8793 6.8837

S.E. 6.9 0.031 24.0774 3.9845 0.9736 2.2746 1.9871

 N 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT

Page 890 of 1107
 TABLE A46 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G]

 MALE GROUP: 0 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 TESTI EPIDIDY CAUDA E PITU EPIDIDY CAUDA E

 ANIMAL S, LT MIS, LT PID, LT ITARY MIS, RT PID, RT

-----------------------------------------------------------------------------------------------------------------------------------

 91555 70.370 26.852 11.630 0.824 27.315 11.620

 91560 75.785 26.906 13.202 0.668 28.700 12.184

 91562 76.098 27.805 12.488 0.649 30.244 13.122

 91563 79.327 26.442 13.418 0.683 30.769 13.837

 91564 78.095 26.667 13.205 0.848 29.524 12.748

 91567 85.484 29.570 14.495 0.548 33.333 14.570

 91579 76.498 29.032 13.129 0.825 28.111 11.438

 91586 75.943 26.887 13.184 1.071 31.604 13.925

 91591 80.569 26.066 13.152 0.645 28.436 12.578

 91592 77.193 27.632 13.171 0.649 29.386 12.189

 91609 82.407 31.944 14.681 0.671 33.333 14.241

 91615 76.279 27.907 14.065 0.740 30.698 12.874

MEAN 77.837 27.809 13.318 0.735 30.121 12.944

S.D. 3.8177 1.6660 0.8245 0.1383 1.9371 1.0209

S.E. 1.1021 0.4809 0.2380 0.0399 0.5592 0.2947

 N 12 12 12 12 12 12

Page 891 of 1107
 TABLE A46 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G]

 MALE GROUP: 50 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 TESTI EPIDIDY CAUDA E PITU EPIDIDY CAUDA E

 ANIMAL S, LT MIS, LT PID, LT ITARY MIS, RT PID, RT

-----------------------------------------------------------------------------------------------------------------------------------

 91556 86.082 32.990 14.567 0.649 35.052 14.639

 91559 91.795 30.256 15.231 0.733 31.795 12.503

 91561 77.034 32.536 15.416 0.842 33.014 15.230

 91566 92.513 32.620 13.882 0.642 35.829 13.604

 91576 79.904 28.708 14.038 0.641 30.622 14.617

 91582 88.785 29.907 14.332 0.757 32.710 12.963

 91585 84.314 32.843 14.358 0.853 33.824 13.971

 91589 75.743 26.733 12.822 0.639 28.218 12.713

 91593 67.742 25.346 12.207 0.760 28.111 12.590

 91594 78.261 28.019 15.101 0.739 28.986 13.473

 91595 77.626 30.594 15.703 0.667 32.420 13.973

 91602 95.767 32.804 16.138 0.635 34.392 16.254

MEAN 82.964 30.280 14.483 0.713 32.081 13.878

S.D. 8.2986 2.6216 1.1513 0.0795 2.6131 1.1520

S.E. 2.3956 0.7568 0.3324 0.0230 0.7543 0.3326

 N 12 12 12 12 12 12

Page 892 of 1107
 TABLE A46 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G]

 MALE GROUP: 100 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 TESTI EPIDIDY CAUDA E PITU EPIDIDY CAUDA E

 ANIMAL S, LT MIS, LT PID, LT ITARY MIS, RT PID, RT

-----------------------------------------------------------------------------------------------------------------------------------

 91569 71.845 26.214 11.641 0.500 27.184 10.500

 91573 86.111 30.093 13.856 0.620 33.796 14.528

 91577 77.723 26.238 12.926 0.520 28.218 12.149

 91581 76.812 28.502 14.686 0.604 30.918 13.367

 91583 86.139 30.198 13.807 0.589 32.673 13.579

 91588 92.965 31.658 15.060 0.628 32.161 15.151

 91590 71.101 26.147 13.046 0.693 28.899 12.807

 91598 78.680 28.934 13.782 0.690 29.949 12.888

 91599 75.248 27.723 12.703 0.609 29.703 13.030

 91608 86.700 28.079 12.897 0.576 31.527 12.823

 91611 86.154 33.846 15.862 0.667 33.846 13.082

 91616 87.440 28.019 13.280 0.681 31.884 13.261

MEAN 81.410 28.804 13.629 0.615 30.897 13.097

S.D. 7.0243 2.3345 1.1505 0.0629 2.1427 1.1461

S.E. 2.0278 0.6739 0.3321 0.0182 0.6186 0.3309

 N 12 12 12 12 12 12

Page 893 of 1107
 TABLE A46 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G]

 MALE GROUP: 175 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 TESTI EPIDIDY CAUDA E PITU EPIDIDY CAUDA E

 ANIMAL S, LT MIS, LT PID, LT ITARY MIS, RT PID, RT

-----------------------------------------------------------------------------------------------------------------------------------

 91565 68.447 25.728 12.257 0.515 28.641 12.252

 91568 80.402 31.156 14.678 0.704 31.156 12.513

 91570 87.958 31.937 13.524 0.649 33.508 14.911

 91572 78.947 28.708 13.029 0.579 30.144 13.388

 91580 86.000 29.000 14.330 0.630 28.000 12.020

 91584 86.139 32.673 13.649 0.683 30.693 12.540

 91587 92.118 32.512 15.739 0.665 32.512 13.414

 91597 91.623 30.890 13.969 0.592 34.555 14.372

 91601 77.941 29.412 13.853 0.583 30.392 13.201

 91607 77.880 28.571 13.313 0.608 32.719 13.779

 91613 78.392 28.141 11.221 0.724 30.653 11.518

 91614 83.756 34.518 16.650 0.650 36.041 15.746

MEAN 82.467 30.271 13.851 0.632 31.584 13.305

S.D. 6.7831 2.4427 1.4427 0.0595 2.3623 1.2467

S.E. 1.9581 0.7051 0.4165 0.0172 0.6819 0.3599

 N 12 12 12 12 12 12

Page 894 of 1107
 TABLE A46 (F0 MALES)

PROJECT NO.:WIL-65501M RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G]

 MALE GROUP: 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 TESTI EPIDIDY CAUDA E PITU EPIDIDY CAUDA E

 ANIMAL S, LT MIS, LT PID, LT ITARY MIS, RT PID, RT

-----------------------------------------------------------------------------------------------------------------------------------

 91554 77.157 31.980 15.127 0.660 28.934 11.497

 91557 87.442 28.837 12.609 0.740 30.698 13.767

 91558 81.443 28.351 14.284 0.552 31.959 13.670

 91571 76.142 27.919 13.670 0.635 29.442 13.442

 91575 71.101 25.688 9.651 0.560 27.064 11.413

 91600 80.751 30.047 14.925 0.620 34.272 14.897

 91603 89.637 34.197 14.668 0.637 35.233 13.223

 91604 90.476 33.862 15.217 0.788 35.979 13.857

 91605 93.000 30.000 15.095 0.635 30.500 12.530

 91612 86.111 30.556 14.287 0.620 34.259 12.944

 91618 71.429 26.728 12.226 0.724 29.032 12.410

 91619 79.024 25.854 12.605 0.639 27.317 11.366

MEAN 81.976 29.501 13.697 0.651 31.224 12.918

S.D. 7.3653 2.8392 1.6613 0.0694 3.0796 1.1101

S.E. 2.1262 0.8196 0.4796 0.0200 0.8890 0.3204

 N 12 12 12 12 12 12

 POFBWv4.31

 11/25/2013

 R:01/17/2014

Page 895 of 1107
 TABLE A47 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]

 FEMALE GROUP: 0 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 PITU

 ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS OVARIES ITARY

-----------------------------------------------------------------------------------------------------------------------------------

 91629 308. 1.96 12.71 2.16 0.67 1.47 0.1023 0.0143

 91630 324. 1.96 15.97 2.32 0.59 1.53 0.0903 0.0198

 91633 361. 2.02 14.39 2.41 0.82 1.33 0.1462 0.0214

 91637 320. 1.94 12.77 2.31 0.64 1.25 0.1021 0.0173

 91639 361. 1.95 14.15 2.13 0.65 1.54 0.1524 0.0201

 91644 313. 1.89 13.08 2.37 0.66 1.57 0.1213 0.0225

 91645 342. 1.98 15.82 2.32 0.61 1.50 0.1106 0.0201

 91648 359. 1.95 14.92 2.34 0.77 1.47 0.1255 0.0203

 91653 347. 1.95 13.47 2.20 0.75 1.19 0.1329 0.0220

 91660 368. 2.09 15.74 2.42 0.72 1.53 0.1325 0.0271

 91670 332. 2.01 13.90 2.31 0.59 1.43 0.1371 0.0205

 91672 374. 2.06 17.93 2.37 0.91 1.76 0.1561 0.0229

MEAN 342. 1.98 14.57 2.31 0.70 1.46 0.1258 0.0207

S.D. 22.6 0.056 1.569 0.094 0.099 0.152 0.02109 0.00310

S.E. 6.5 0.016 0.453 0.027 0.028 0.044 0.00609 0.00089

 N 12 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT

Page 896 of 1107
 TABLE A47 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]

 FEMALE GROUP: 50 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 PITU

 ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS OVARIES ITARY

-----------------------------------------------------------------------------------------------------------------------------------

 91632 321. 1.87 12.83 2.39 0.59 1.45 0.1072 0.0188

 91640 362. 2.02 15.05 2.55 1.09 1.89 0.1252 0.0206

 91642 349. 1.88 14.48 2.53 0.80 1.51 0.0948 0.0212

 91647 296. 1.80 12.87 2.04 0.58 1.39 0.0989 0.0189

 91651 329. 1.91 14.86 2.37 0.61 1.69 0.0894 0.0168

 91659 371. 2.10 16.38 2.43 0.82 1.51 0.1208 0.0205

 91661 315. 1.92 13.20 2.35 0.61 1.54 0.1072 0.0160

 91663 324. 1.94 12.37 2.13 0.64 1.40 0.1085 0.0183

 91669 325. 2.09 13.48 2.11 0.84 1.49 0.1419 0.0171

 91673 321. 2.00 14.97 2.51 0.70 1.65 0.1319 0.0200

 91683 321. 1.89 13.75 2.19 0.74 1.43 0.1099 0.0194

 91685 292. 2.04 11.44 2.02 0.57 1.45 0.1351 0.0198

MEAN 327. 1.96 13.81 2.30 0.72 1.53 0.1142 0.0190

S.D. 23.5 0.094 1.384 0.194 0.153 0.145 0.01667 0.00164

S.E. 6.8 0.027 0.399 0.056 0.044 0.042 0.00481 0.00047

 N 12 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT

Page 897 of 1107
 TABLE A47 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]

 FEMALE GROUP: 100 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 PITU

 ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS OVARIES ITARY

-----------------------------------------------------------------------------------------------------------------------------------

 91620 351. 1.89 13.72 2.31 0.98 1.44 0.1291 0.0166

 91628 289. 1.93 12.30 2.02 0.59 1.39 0.1142 0.0161

 91631 351. 1.87 15.89 2.79 0.76 1.43 0.1094 0.0159

 91636 289. 1.86 12.10 2.07 0.72 1.41 0.1071 0.0176

 91649 305. 1.87 13.32 2.22 0.89 1.47 0.1284 0.0121

 91650 355. 1.88 14.91 2.46 0.94 1.62 0.1214 0.0210

 91656 330. 1.93 13.29 2.22 0.60 1.51 0.0969 0.0159

 91671 346. 1.90 14.61 2.22 1.19 1.41 0.1100 0.0179

 91675 359. 2.06 14.93 2.45 0.91 1.56 0.1321 0.0140

 91677 309. 2.00 11.13 2.20 0.66 1.37 0.1184 0.0138

 91679 338. 1.94 13.87 2.25 1.15 1.90 0.1544 0.0126

 91684 286. 1.96 12.90 1.76 0.53 1.48 0.1091 0.0132

MEAN 326. 1.92 13.58 2.25 0.83 1.50 0.1192 0.0156

S.D. 28.3 0.060 1.366 0.254 0.218 0.146 0.01521 0.00257

S.E. 8.2 0.017 0.394 0.073 0.063 0.042 0.00439 0.00074

 N 12 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT

Page 898 of 1107
 TABLE A47 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]

 FEMALE GROUP: 175 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 PITU

 ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS OVARIES ITARY

-----------------------------------------------------------------------------------------------------------------------------------

 91622 301. 1.96 14.01 2.10 0.96 1.68 0.1147 0.0162

 91626 367. 2.14 15.70 2.26 0.77 1.54 0.1211 0.0247

 91643 360. 2.07 15.14 2.32 1.13 1.60 0.1118 0.0199

 91657 354. 1.89 14.64 2.70 0.77 1.64 0.1375 0.0174

 91662 330. 1.92 14.66 2.39 0.76 1.53 0.1244 0.0147

 91666 285. 1.88 11.95 2.03 0.79 1.42 0.0850 0.0105

 91676 317. 1.97 13.90 2.42 0.80 1.46 0.0890 0.0174

 91678 396. 2.08 16.10 2.38 0.90 1.61 0.1343 0.0221

 91681 320. 2.00 13.84 2.26 0.69 1.49 0.1230 0.0170

 91682 338. 1.97 14.44 2.42 1.10 1.46 0.1347 0.0146

MEAN 337. 1.99 14.44 2.33 0.87 1.54 0.1176 0.0175

S.D. 33.2 0.085 1.153 0.186 0.151 0.087 0.01819 0.00403

S.E. 10.5 0.027 0.365 0.059 0.048 0.027 0.00575 0.00127

 N 10 10 10 10 10 10 10 10

FBW = FINAL BODY WEIGHT

Page 899 of 1107
 TABLE A47 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]

 FEMALE GROUP: 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 PITU

 ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS OVARIES ITARY

-----------------------------------------------------------------------------------------------------------------------------------

 91624 321. 2.03 12.89 2.18 0.75 1.47 0.1124 0.0161

 91625 293. 1.85 12.81 1.74 0.56 1.20 0.1289 0.0199

 91627 303. 1.92 12.77 2.27 0.68 1.42 0.1083 0.0189

 91634 331. 1.95 13.39 2.60 0.64 1.42 0.1248 0.0169

 91635 338. 2.13 14.56 2.11 0.73 1.53 0.1147 0.0193

 91638 319. 2.06 11.86 1.95 0.57 1.43 0.1067 0.0169

 91652 355. 1.94 14.76 2.46 0.97 1.52 0.1185 0.0180

 91655 317. 1.96 14.16 2.57 0.91 1.52 0.1034 0.0141

 91658 325. 1.96 13.86 2.17 0.63 1.28 0.0901 0.0161

 91667 348. 1.89 14.53 2.31 0.60 1.33 0.1316 0.0192

 91668 342. 2.06 14.59 2.65 1.31 1.60 0.1886 0.0161

 91680 325. 1.93 13.70 2.00 0.56 1.54 0.1366 0.0190

MEAN 326. 1.97 13.66 2.25 0.74 1.44 0.1221 0.0175

S.D. 17.9 0.081 0.922 0.282 0.223 0.118 0.02475 0.00177

S.E. 5.2 0.023 0.266 0.081 0.064 0.034 0.00715 0.00051

 N 12 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT

 POFBWv4.31

 01/20/2014

Page 900 of 1107
 TABLE A48 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]

 FEMALE GROUP: 0 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 PITU

 ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS OVARIES ITARY

-----------------------------------------------------------------------------------------------------------------------------------

 91629 308. 0.636 4.127 0.701 0.218 0.477 0.033 0.005

 91630 324. 0.605 4.929 0.716 0.182 0.472 0.028 0.006

 91633 361. 0.560 3.986 0.668 0.227 0.368 0.040 0.006

 91637 320. 0.606 3.991 0.722 0.200 0.391 0.032 0.005

 91639 361. 0.540 3.920 0.590 0.180 0.427 0.042 0.006

 91644 313. 0.604 4.179 0.757 0.211 0.502 0.039 0.007

 91645 342. 0.579 4.626 0.678 0.178 0.439 0.032 0.006

 91648 359. 0.543 4.156 0.652 0.214 0.409 0.035 0.006

 91653 347. 0.562 3.882 0.634 0.216 0.343 0.038 0.006

 91660 368. 0.568 4.277 0.658 0.196 0.416 0.036 0.007

 91670 332. 0.605 4.187 0.696 0.178 0.431 0.041 0.006

 91672 374. 0.551 4.794 0.634 0.243 0.471 0.042 0.006

MEAN 342. 0.580 4.254 0.675 0.204 0.429 0.037 0.006

S.D. 22.6 0.0307 0.3456 0.0460 0.0214 0.0471 0.0046 0.0006

S.E. 6.5 0.0089 0.0998 0.0133 0.0062 0.0136 0.0013 0.0002

 N 12 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT

Page 901 of 1107
 TABLE A48 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]

 FEMALE GROUP: 50 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 PITU

 ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS OVARIES ITARY

-----------------------------------------------------------------------------------------------------------------------------------

 91632 321. 0.583 3.997 0.745 0.184 0.452 0.033 0.006

 91640 362. 0.558 4.157 0.704 0.301 0.522 0.035 0.006

 91642 349. 0.539 4.149 0.725 0.229 0.433 0.027 0.006

 91647 296. 0.608 4.348 0.689 0.196 0.470 0.033 0.006

 91651 329. 0.581 4.517 0.720 0.185 0.514 0.027 0.005

 91659 371. 0.566 4.415 0.655 0.221 0.407 0.033 0.006

 91661 315. 0.610 4.190 0.746 0.194 0.489 0.034 0.005

 91663 324. 0.599 3.818 0.657 0.198 0.432 0.033 0.006

 91669 325. 0.643 4.148 0.649 0.258 0.458 0.044 0.005

 91673 321. 0.623 4.664 0.782 0.218 0.514 0.041 0.006

 91683 321. 0.589 4.283 0.682 0.231 0.445 0.034 0.006

 91685 292. 0.699 3.918 0.692 0.195 0.497 0.046 0.007

MEAN 327. 0.600 4.217 0.704 0.217 0.469 0.035 0.006

S.D. 23.5 0.0424 0.2451 0.0411 0.0345 0.0375 0.0059 0.0006

S.E. 6.8 0.0122 0.0708 0.0119 0.0100 0.0108 0.0017 0.0002

 N 12 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT

Page 902 of 1107
 TABLE A48 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]

 FEMALE GROUP: 100 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 PITU

 ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS OVARIES ITARY

-----------------------------------------------------------------------------------------------------------------------------------

 91620 351. 0.538 3.909 0.658 0.279 0.410 0.037 0.005

 91628 289. 0.668 4.256 0.699 0.204 0.481 0.040 0.006

 91631 351. 0.533 4.527 0.795 0.217 0.407 0.031 0.005

 91636 289. 0.644 4.187 0.716 0.249 0.488 0.037 0.006

 91649 305. 0.613 4.367 0.728 0.292 0.482 0.042 0.004

 91650 355. 0.530 4.200 0.693 0.265 0.456 0.034 0.006

 91656 330. 0.585 4.027 0.673 0.182 0.458 0.029 0.005

 91671 346. 0.549 4.223 0.642 0.344 0.408 0.032 0.005

 91675 359. 0.574 4.159 0.682 0.253 0.435 0.037 0.004

 91677 309. 0.647 3.602 0.712 0.214 0.443 0.038 0.004

 91679 338. 0.574 4.104 0.666 0.340 0.562 0.046 0.004

 91684 286. 0.685 4.510 0.615 0.185 0.517 0.038 0.005

MEAN 326. 0.595 4.173 0.690 0.252 0.462 0.037 0.005

S.D. 28.3 0.0550 0.2540 0.0463 0.0549 0.0470 0.0046 0.0008

S.E. 8.2 0.0159 0.0733 0.0134 0.0158 0.0136 0.0013 0.0002

 N 12 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT

Page 903 of 1107
 TABLE A48 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]

 FEMALE GROUP: 175 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 PITU

 ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS OVARIES ITARY

-----------------------------------------------------------------------------------------------------------------------------------

 91622 301. 0.651 4.654 0.698 0.319 0.558 0.038 0.005

 91626 367. 0.583 4.278 0.616 0.210 0.420 0.033 0.007

 91643 360. 0.575 4.206 0.644 0.314 0.444 0.031 0.006

 91657 354. 0.534 4.136 0.763 0.218 0.463 0.039 0.005

 91662 330. 0.582 4.442 0.724 0.230 0.464 0.038 0.004

 91666 285. 0.660 4.193 0.712 0.277 0.498 0.030 0.004

 91676 317. 0.621 4.385 0.763 0.252 0.461 0.028 0.005

 91678 396. 0.525 4.066 0.601 0.227 0.407 0.034 0.006

 91681 320. 0.625 4.325 0.706 0.216 0.466 0.038 0.005

 91682 338. 0.583 4.272 0.716 0.325 0.432 0.040 0.004

MEAN 337. 0.594 4.296 0.694 0.259 0.461 0.035 0.005

S.D. 33.2 0.0452 0.1690 0.0564 0.0462 0.0430 0.0042 0.0010

S.E. 10.5 0.0143 0.0535 0.0178 0.0146 0.0136 0.0013 0.0003

 N 10 10 10 10 10 10 10 10

FBW = FINAL BODY WEIGHT

Page 904 of 1107
 TABLE A48 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]

 FEMALE GROUP: 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 PITU

 ANIMAL FBW(G) BRAIN LIVER KIDNEYS SPLEEN LUNGS OVARIES ITARY

-----------------------------------------------------------------------------------------------------------------------------------

 91624 321. 0.632 4.016 0.679 0.234 0.458 0.035 0.005

 91625 293. 0.631 4.372 0.594 0.191 0.410 0.044 0.007

 91627 303. 0.634 4.215 0.749 0.224 0.469 0.036 0.006

 91634 331. 0.589 4.045 0.785 0.193 0.429 0.038 0.005

 91635 338. 0.630 4.308 0.624 0.216 0.453 0.034 0.006

 91638 319. 0.646 3.718 0.611 0.179 0.448 0.033 0.005

 91652 355. 0.546 4.158 0.693 0.273 0.428 0.033 0.005

 91655 317. 0.618 4.467 0.811 0.287 0.479 0.033 0.004

 91658 325. 0.603 4.265 0.668 0.194 0.394 0.028 0.005

 91667 348. 0.543 4.175 0.664 0.172 0.382 0.038 0.006

 91668 342. 0.602 4.266 0.775 0.383 0.468 0.055 0.005

 91680 325. 0.594 4.215 0.615 0.172 0.474 0.042 0.006

MEAN 326. 0.606 4.185 0.689 0.227 0.441 0.037 0.005

S.D. 17.9 0.0335 0.1934 0.0745 0.0619 0.0323 0.0071 0.0008

S.E. 5.2 0.0097 0.0558 0.0215 0.0179 0.0093 0.0020 0.0002

 N 12 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT

 POFBWv4.31

 01/20/2014

Page 905 of 1107
 TABLE A49 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G]

 FEMALE GROUP: 0 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 BRAIN WT PITU

 ANIMAL FBW(G) (GRAMS) LIVER KIDNEYS SPLEEN LUNGS OVARIES ITARY

-----------------------------------------------------------------------------------------------------------------------------------

 91629 308. 1.96 648.469 110.204 34.184 75.000 5.219 0.730

 91630 324. 1.96 814.796 118.367 30.102 78.061 4.607 1.010

 91633 361. 2.02 712.376 119.307 40.594 65.842 7.238 1.059

 91637 320. 1.94 658.247 119.072 32.990 64.433 5.263 0.892

 91639 361. 1.95 725.641 109.231 33.333 78.974 7.815 1.031

 91644 313. 1.89 692.063 125.397 34.921 83.069 6.418 1.190

 91645 342. 1.98 798.990 117.172 30.808 75.758 5.586 1.015

 91648 359. 1.95 765.128 120.000 39.487 75.385 6.436 1.041

 91653 347. 1.95 690.769 112.821 38.462 61.026 6.815 1.128

 91660 368. 2.09 753.110 115.789 34.450 73.206 6.340 1.297

 91670 332. 2.01 691.542 114.925 29.353 71.144 6.821 1.020

 91672 374. 2.06 870.388 115.049 44.175 85.437 7.578 1.112

MEAN 342. 1.98 735.127 116.444 35.238 73.944 6.345 1.044

S.D. 22.6 0.056 67.2134 4.4814 4.5542 7.3575 0.9988 0.1420

S.E. 6.5 0.016 19.4028 1.2937 1.3147 2.1239 0.2883 0.0410

 N 12 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT

Page 906 of 1107
 TABLE A49 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G]

 FEMALE GROUP: 50 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 BRAIN WT PITU

 ANIMAL FBW(G) (GRAMS) LIVER KIDNEYS SPLEEN LUNGS OVARIES ITARY

-----------------------------------------------------------------------------------------------------------------------------------

 91632 321. 1.87 686.096 127.807 31.551 77.540 5.733 1.005

 91640 362. 2.02 745.050 126.238 53.960 93.564 6.198 1.020

 91642 349. 1.88 770.213 134.574 42.553 80.319 5.043 1.128

 91647 296. 1.80 715.000 113.333 32.222 77.222 5.494 1.050

 91651 329. 1.91 778.010 124.084 31.937 88.482 4.681 0.880

 91659 371. 2.10 780.000 115.714 39.048 71.905 5.752 0.976

 91661 315. 1.92 687.500 122.396 31.771 80.208 5.583 0.833

 91663 324. 1.94 637.629 109.794 32.990 72.165 5.593 0.943

 91669 325. 2.09 644.976 100.957 40.191 71.292 6.789 0.818

 91673 321. 2.00 748.500 125.500 35.000 82.500 6.595 1.000

 91683 321. 1.89 727.513 115.873 39.153 75.661 5.815 1.026

 91685 292. 2.04 560.784 99.020 27.941 71.078 6.623 0.971

MEAN 327. 1.96 706.773 117.941 36.526 78.495 5.825 0.971

S.D. 23.5 0.094 66.6586 10.8749 7.0224 7.0716 0.6364 0.0904

S.E. 6.8 0.027 19.2427 3.1393 2.0272 2.0414 0.1837 0.0261

 N 12 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT

Page 907 of 1107
 TABLE A49 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G]

 FEMALE GROUP: 100 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 BRAIN WT PITU

 ANIMAL FBW(G) (GRAMS) LIVER KIDNEYS SPLEEN LUNGS OVARIES ITARY

-----------------------------------------------------------------------------------------------------------------------------------

 91620 351. 1.89 725.926 122.222 51.852 76.190 6.831 0.878

 91628 289. 1.93 637.306 104.663 30.570 72.021 5.917 0.834

 91631 351. 1.87 849.733 149.198 40.642 76.471 5.850 0.850

 91636 289. 1.86 650.538 111.290 38.710 75.806 5.758 0.946

 91649 305. 1.87 712.299 118.717 47.594 78.610 6.866 0.647

 91650 355. 1.88 793.085 130.851 50.000 86.170 6.457 1.117

 91656 330. 1.93 688.601 115.026 31.088 78.238 5.021 0.824

 91671 346. 1.90 768.947 116.842 62.632 74.211 5.789 0.942

 91675 359. 2.06 724.757 118.932 44.175 75.728 6.413 0.680

 91677 309. 2.00 556.500 110.000 33.000 68.500 5.920 0.690

 91679 338. 1.94 714.948 115.979 59.278 97.938 7.959 0.649

 91684 286. 1.96 658.163 89.796 27.041 75.510 5.566 0.673

MEAN 326. 1.92 706.734 116.960 43.048 77.949 6.196 0.811

S.D. 28.3 0.060 77.3444 14.2743 11.5808 7.5488 0.7677 0.1476

S.E. 8.2 0.017 22.3274 4.1206 3.3431 2.1791 0.2216 0.0426

 N 12 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT

Page 908 of 1107
 TABLE A49 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G]

 FEMALE GROUP: 175 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 BRAIN WT PITU

 ANIMAL FBW(G) (GRAMS) LIVER KIDNEYS SPLEEN LUNGS OVARIES ITARY

-----------------------------------------------------------------------------------------------------------------------------------

 91622 301. 1.96 714.796 107.143 48.980 85.714 5.852 0.827

 91626 367. 2.14 733.645 105.607 35.981 71.963 5.659 1.154

 91643 360. 2.07 731.401 112.077 54.589 77.295 5.401 0.961

 91657 354. 1.89 774.603 142.857 40.741 86.772 7.275 0.921

 91662 330. 1.92 763.542 124.479 39.583 79.688 6.479 0.766

 91666 285. 1.88 635.638 107.979 42.021 75.532 4.521 0.559

 91676 317. 1.97 705.584 122.843 40.609 74.112 4.518 0.883

 91678 396. 2.08 774.039 114.423 43.269 77.404 6.457 1.063

 91681 320. 2.00 692.000 113.000 34.500 74.500 6.150 0.850

 91682 338. 1.97 732.995 122.843 55.838 74.112 6.838 0.741

MEAN 337. 1.99 725.824 117.325 43.611 77.709 5.915 0.873

S.D. 33.2 0.085 42.2679 11.2889 7.2738 4.9928 0.9187 0.1684

S.E. 10.5 0.027 13.3663 3.5699 2.3002 1.5789 0.2905 0.0533

 N 10 10 10 10 10 10 10 10

FBW = FINAL BODY WEIGHT

Page 909 of 1107
 TABLE A49 (F0 FEMALES - LACTATION DAY 4)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G]

 FEMALE GROUP: 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

 BRAIN WT PITU

 ANIMAL FBW(G) (GRAMS) LIVER KIDNEYS SPLEEN LUNGS OVARIES ITARY

-----------------------------------------------------------------------------------------------------------------------------------

 91624 321. 2.03 634.975 107.389 36.946 72.414 5.537 0.793

 91625 293. 1.85 692.432 94.054 30.270 64.865 6.968 1.076

 91627 303. 1.92 665.104 118.229 35.417 73.958 5.641 0.984

 91634 331. 1.95 686.667 133.333 32.821 72.821 6.400 0.867

 91635 338. 2.13 683.568 99.061 34.272 71.831 5.385 0.906

 91638 319. 2.06 575.728 94.660 27.670 69.417 5.180 0.820

 91652 355. 1.94 760.825 126.804 50.000 78.351 6.108 0.928

 91655 317. 1.96 722.449 131.122 46.429 77.551 5.276 0.719

 91658 325. 1.96 707.143 110.714 32.143 65.306 4.597 0.821

 91667 348. 1.89 768.783 122.222 31.746 70.370 6.963 1.016

 91668 342. 2.06 708.253 128.641 63.592 77.670 9.155 0.782

 91680 325. 1.93 709.845 103.627 29.016 79.793 7.078 0.984

MEAN 326. 1.97 692.981 114.155 37.527 72.862 6.191 0.891

S.D. 17.9 0.081 52.1833 14.4209 10.6020 4.9068 1.2287 0.1088

S.E. 5.2 0.023 15.0640 4.1630 3.0605 1.4165 0.3547 0.0314

 N 12 12 12 12 12 12 12 12

FBW = FINAL BODY WEIGHT

 POFBWv4.31

 01/20/2014

Page 910 of 1107
 TABLE A50 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OVARIAN PRIMORDIAL FOLLICLE COUNTS

 0 PPM

 PRIMORDIAL

ANIMAL FOLLICLES

-----------------------------------------------------------------------------------------------------------------------------------

91629 85

91630 44

91633 42

91637 70

91639 58

91644 45

91645 48

91648 74

91653 38

91660 26

91670 58

91672 4

-----------------------------------------------------------------------------------------------------------------------------------

MEAN 49.3

S.D. 21.93

S.E. 6.33

 N 12

Page 911 of 1107
 TABLE A50 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OVARIAN PRIMORDIAL FOLLICLE COUNTS

 175 PPM

 PRIMORDIAL

ANIMAL FOLLICLES

-----------------------------------------------------------------------------------------------------------------------------------

91623 36

91622 23

91626 62

91643 60

91654 54

91657 34

91662 26

91666 66

91676 19

91678 28

91681 62

91682 47

-----------------------------------------------------------------------------------------------------------------------------------

MEAN 43.1

S.D. 17.31

S.E. 5.00

 N 12

Page 912 of 1107
 TABLE A50 (F0 FEMALES)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OVARIAN PRIMORDIAL FOLLICLE COUNTS

 10000 PPM

 PRIMORDIAL

ANIMAL FOLLICLES

-----------------------------------------------------------------------------------------------------------------------------------

91624 54

91625 63

91627 75

91634 42

91635 8

91638 51

91652 214

91655 57

91658 111

91667 59

91668 44

91680 38

-----------------------------------------------------------------------------------------------------------------------------------

MEAN 68.0

S.D. 51.94

S.E. 14.99

 N 12

 MANUALv1.0

 01/21/2014

 R:01/24/2014

Page 913 of 1107
 TABLE A51 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL LITTER VIABILITY

 GROUP: 0 PPM

-----------------------------------------------------------------------------------------------------------------------------------

DAM # PND 0 1 2 3 4

-----------------------------------------------------------------------------------------------------------------------------------

 91629 ALIVE 16 16 15 15 0

 DEAD 1

 SCHED. EUTH. 15

 91630 ALIVE 12 12 12 12 0

 DEAD 2

 SCHED. EUTH. 12

 91633 ALIVE 15 15 15 15 0

 SCHED. EUTH. 15

 91637 ALIVE 13 13 13 12 0

 DEAD 1

 SCHED. EUTH. 12

 91639 ALIVE 10 9 9 9 0

 DEAD 1

 SCHED. EUTH. 9

 91644 ALIVE 17 17 17 17 0

 SCHED. EUTH. 16

 MISSING 1

 91645 ALIVE 15 15 15 15 0

 DEAD 1

 SCHED. EUTH. 15

 91648 ALIVE 13 13 13 13 0

 DEAD 1

 SCHED. EUTH. 13

 91653 ALIVE 15 15 15 15 0

 SCHED. EUTH. 15

-----------------------------------------------------------------------------------------------------------------------------------

DEAD= FOUND DEAD, SCHED. EUTH.= SCHEDULED EUTHANASIA

Page 914 of 1107
 TABLE A51 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL LITTER VIABILITY

 GROUP: 0 PPM

-----------------------------------------------------------------------------------------------------------------------------------

DAM # PND 0 1 2 3 4

-----------------------------------------------------------------------------------------------------------------------------------

 91660 ALIVE 13 13 13 13 0

 DEAD 1

 SCHED. EUTH. 13

 91670 ALIVE 14 14 14 14 0

 SCHED. EUTH. 14

 91672 ALIVE 13 13 12 12 0

 DEAD 1 1 1

 SCHED. EUTH. 11

-----------------------------------------------------------------------------------------------------------------------------------

DEAD= FOUND DEAD, SCHED. EUTH.= SCHEDULED EUTHANASIA

Page 915 of 1107
 TABLE A51 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL LITTER VIABILITY

 GROUP: 50 PPM

-----------------------------------------------------------------------------------------------------------------------------------

DAM # PND 0 1 2 3 4

-----------------------------------------------------------------------------------------------------------------------------------

 91632 ALIVE 15 15 14 14 0

 DEAD 1

 SCHED. EUTH. 14

 91640 ALIVE 10 10 10 10 0

 DEAD 2

 SCHED. EUTH. 10

 91642 ALIVE 15 15 15 15 0

 SCHED. EUTH. 15

 91647 ALIVE 12 11 11 11 0

 DEAD 1

 SCHED. EUTH. 11

 MISSING 1

 91651 ALIVE 12 12 12 12 0

 SCHED. EUTH. 12

 91659 ALIVE 13 12 12 12 0

 DEAD 1

 SCHED. EUTH. 12

 91661 ALIVE 17 17 17 17 0

 SCHED. EUTH. 17

 91663 ALIVE 15 14 14 14 0

 DEAD 1 1

 SCHED. EUTH. 13

 91669 ALIVE 16 16 16 15 0

 DEAD 1 3

 SCHED. EUTH. 12

 91673 ALIVE 16 16 16 16 0

 SCHED. EUTH. 16

-----------------------------------------------------------------------------------------------------------------------------------

DEAD= FOUND DEAD, SCHED. EUTH.= SCHEDULED EUTHANASIA

Page 916 of 1107
 TABLE A51 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL LITTER VIABILITY

 GROUP: 50 PPM

-----------------------------------------------------------------------------------------------------------------------------------

DAM # PND 0 1 2 3 4

-----------------------------------------------------------------------------------------------------------------------------------

 91683 ALIVE 12 12 12 12 0

 SCHED. EUTH. 12

 91685 ALIVE 10 10 9 9 0

 SCHED. EUTH. 9

 MISSING 1

-----------------------------------------------------------------------------------------------------------------------------------

SCHED. EUTH.= SCHEDULED EUTHANASIA

Page 917 of 1107
 TABLE A51 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL LITTER VIABILITY

 GROUP: 100 PPM

-----------------------------------------------------------------------------------------------------------------------------------

DAM # PND 0 1 2 3 4

-----------------------------------------------------------------------------------------------------------------------------------

 91620 ALIVE 13 13 13 13 0

 DEAD 1

 SCHED. EUTH. 13

 91628 ALIVE 14 14 14 14 0

 DEAD 1

 SCHED. EUTH. 14

 91631 ALIVE 15 15 14 13 0

 DEAD 1 1

 SCHED. EUTH. 13

 91636 ALIVE 13 13 13 13 0

 SCHED. EUTH. 13

 91649 ALIVE 16 16 16 16 0

 SCHED. EUTH. 16

 91650 ALIVE 13 13 13 13 0

 DEAD 1

 SCHED. EUTH. 13

 91656 ALIVE 14 12 12 11 0

 DEAD 1

 SCHED. EUTH. 11

 MISSING 2 1

 91671 ALIVE 13 11 11 11 0

 DEAD 2 1

 SCHED. EUTH. 11

 MISSING 1

 91675 ALIVE 14 13 12 12 0

 DEAD 1 1

 SCHED. EUTH. 11

 MISSING 1

-----------------------------------------------------------------------------------------------------------------------------------

DEAD= FOUND DEAD, SCHED. EUTH.= SCHEDULED EUTHANASIA

Page 918 of 1107
 TABLE A51 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL LITTER VIABILITY

 GROUP: 100 PPM

-----------------------------------------------------------------------------------------------------------------------------------

DAM # PND 0 1 2 3 4

-----------------------------------------------------------------------------------------------------------------------------------

 91677 ALIVE 5 5 5 3 0

 DEAD 1

 SCHED. EUTH. 3

 MISSING 1

 91679 ALIVE 10 9 7 7 0

 DEAD 2 1 1

 SCHED. EUTH. 7

 MISSING 1

 91684 ALIVE 16 16 16 16 0

 SCHED. EUTH. 16

-----------------------------------------------------------------------------------------------------------------------------------

DEAD= FOUND DEAD, SCHED. EUTH.= SCHEDULED EUTHANASIA

Page 919 of 1107
 TABLE A51 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL LITTER VIABILITY

 GROUP: 175 PPM

-----------------------------------------------------------------------------------------------------------------------------------

DAM # PND 0 1 2 3 4

-----------------------------------------------------------------------------------------------------------------------------------

 91622 ALIVE 14 11 9 8 0

 DEAD 3 2 1

 SCHED. EUTH. 8

 91626 ALIVE 14 13 13 13 0

 DEAD 1

 SCHED. EUTH. 13

 91643 ALIVE 12 11 11 11 0

 DEAD 1

 SCHED. EUTH. 11

 91654 ALIVE 16 14 0 TOTAL LITTER LOSS

 DEAD 2 2 8

 MISSING 6

 91657 ALIVE 13 13 8 8 0

 DEAD 5

 SCHED. EUTH. 8

 91662 ALIVE 9 9 8 7 0

 DEAD 2

 SCHED. EUTH. 7

 MISSING 1 1

 91666 ALIVE 11 10 10 10 0

 DEAD 1

 SCHED. EUTH. 10

 91676 ALIVE 11 10 10 10 0

 SCHED. EUTH. 10

 MISSING 1

 91678 ALIVE 14 14 14 14 0

 DEAD 1

 SCHED. EUTH. 13

-----------------------------------------------------------------------------------------------------------------------------------

DEAD= FOUND DEAD, SCHED. EUTH.= SCHEDULED EUTHANASIA

Page 920 of 1107
 TABLE A51 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL LITTER VIABILITY

 GROUP: 175 PPM

-----------------------------------------------------------------------------------------------------------------------------------

DAM # PND 0 1 2 3 4

-----------------------------------------------------------------------------------------------------------------------------------

 91681 ALIVE 13 11 10 10 0

 DEAD 2 1

 SCHED. EUTH. 10

 MISSING 1 1

 91682 ALIVE 12 11 7 5 0

 DEAD 1

 SCHED. EUTH. 5

 MISSING 1 4 2

-----------------------------------------------------------------------------------------------------------------------------------

DEAD= FOUND DEAD, SCHED. EUTH.= SCHEDULED EUTHANASIA

Page 921 of 1107
 TABLE A51 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL LITTER VIABILITY

 GROUP: 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

DAM # PND 0 1 2 3 4

-----------------------------------------------------------------------------------------------------------------------------------

 91624 ALIVE 13 13 13 13 0

 SCHED. EUTH. 13

 91625 ALIVE 14 14 14 14 0

 SCHED. EUTH. 14

 91627 ALIVE 13 13 13 13 0

 SCHED. EUTH. 13

 91634 ALIVE 13 13 13 13 0

 SCHED. EUTH. 13

 91635 ALIVE 12 12 12 12 0

 DEAD 1

 SCHED. EUTH. 12

 91638 ALIVE 16 16 16 16 0

 SCHED. EUTH. 16

 91652 ALIVE 11 11 11 11 0

 DEAD; CANN. 1

 DEAD 1

 SCHED. EUTH. 11

 91655 ALIVE 13 12 11 11 0

 DEAD 1 1

 SCHED. EUTH. 11

 91658 ALIVE 13 13 13 13 0

 SCHED. EUTH. 13

 91667 ALIVE 16 16 16 16 0

 SCHED. EUTH. 16

-----------------------------------------------------------------------------------------------------------------------------------

DEAD; CANN.= FOUND DEAD; PARTIALLY CANNIBALIZED, DEAD= FOUND DEAD, SCHED. EUTH.= SCHEDULED EUTHANASIA

Page 922 of 1107
 TABLE A51 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL LITTER VIABILITY

 GROUP: 10000 PPM

-----------------------------------------------------------------------------------------------------------------------------------

DAM # PND 0 1 2 3 4

-----------------------------------------------------------------------------------------------------------------------------------

 91668 ALIVE 13 13 13 13 0

 DEAD; CANN. 1

 DEAD 1

 SCHED. EUTH. 13

 91680 ALIVE 15 15 15 15 0

 SCHED. EUTH. 15

-----------------------------------------------------------------------------------------------------------------------------------

DEAD; CANN.= FOUND DEAD; PARTIALLY CANNIBALIZED, DEAD= FOUND DEAD, SCHED. EUTH.= SCHEDULED EUTHANASIA

 PPVIAv4.04

 02/18/2014

Page 923 of 1107
 TABLE A52 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP VIABILITY

--------------------------------------------------------

 LITTERS FROM GROUP 1: 0 PPM

--------------------------------------------------------

 DAY OF

 DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

-----------------------------------------------------------------------------------------------------------------------------------

 91629 21-NOV-13 m4 m4 m4 m4 m4 m4 e2 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M M M M M M M M M F F F F

 91630 22-NOV-13 e0 e0 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M M M M M F F F F F F

 91633 19-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M M M M F F F F F F F F

 91637 18-NOV-13 m4 m4 m4 m4 e3 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M M F F F F F F F F

 91639 21-NOV-13 e1 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M M M M M F F

 91644 19-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 s4

 M M M M M M M M M M F F F F F F F

 91645 22-NOV-13 m4 m4 m4 m4 m4 m4 m4 e0 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M M M M M M F F F F F F F

 91648 19-NOV-13 e0 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M M M M M M F F F F F

 91653 21-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M M M F F F F F F F F F

-----------------------------------------------------------------------------------------------------------------------------------

A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4, M = MALE, F = FEMALE, U = UNDETERMINED

e = FOUND DEAD, m = SCHEDULED EUTHANASIA, s = MISSING

Page 924 of 1107
 TABLE A52 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP VIABILITY

--------------------------------------------------------

 LITTERS FROM GROUP 1: 0 PPM

--------------------------------------------------------

 DAY OF

 DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

-----------------------------------------------------------------------------------------------------------------------------------

 91660 21-NOV-13 e0 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M M M M M M F F F F F

 91670 22-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M M M M M F F F F F F

 91672 22-NOV-13 e0 m4 m4 m4 m4 m4 e4 m4 m4 m4 e2 m4 m4 m4

 F M M M M M M M F F F F F F

-----------------------------------------------------------------------------------------------------------------------------------

A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4, M = MALE, F = FEMALE, U = UNDETERMINED

Page 925 of 1107

e = FOUND DEAD, m = SCHEDULED EUTHANASIA
 TABLE A52 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP VIABILITY

--------------------------------------------------------

 LITTERS FROM GROUP 2: 50 PPM

--------------------------------------------------------

 DAY OF

 DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

-----------------------------------------------------------------------------------------------------------------------------------

 91632 23-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 e2

 M M M M F F F F F F F F F F F

 91640 23-NOV-13 e0 e0 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M F M M M F F F F F F

 91642 20-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M F F F F F F F F F F M

 91647 22-NOV-13 e0 s1 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 F M M M M M M M F F F F F

 91651 21-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M M M M F F F F F

 91659 20-NOV-13 e1 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M M M M F F F F F F

 91661 19-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M M M M M M M M F F F F F F

 91663 21-NOV-13 m4 e1 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 e4 m4

 M M M M M M M F F F F F F F F

 91669 19-NOV-13 m4 m4 m4 m4 e4 m4 m4 m4 m4 m4 e4 m4 m4 m4 e4 e3

 M M M M M M M M M F F F F F F F

-----------------------------------------------------------------------------------------------------------------------------------

A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4, M = MALE, F = FEMALE, U = UNDETERMINED

e = FOUND DEAD, m = SCHEDULED EUTHANASIA, s = MISSING

Page 926 of 1107
 TABLE A52 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP VIABILITY

--------------------------------------------------------

 LITTERS FROM GROUP 2: 50 PPM

--------------------------------------------------------

 DAY OF

 DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

-----------------------------------------------------------------------------------------------------------------------------------

 91673 22-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M M M F F F F F F F F F F

 91683 23-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M M M F F F F F F

 91685 19-NOV-13 m4 m4 m4 m4 m4 m4 m4 s2 m4 m4

 M M M M M F F F F F

-----------------------------------------------------------------------------------------------------------------------------------

A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4, M = MALE, F = FEMALE, U = UNDETERMINED

Page 927 of 1107

m = SCHEDULED EUTHANASIA, s = MISSING
 TABLE A52 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP VIABILITY

--------------------------------------------------------

 LITTERS FROM GROUP 3: 100 PPM

--------------------------------------------------------

 DAY OF

 DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

-----------------------------------------------------------------------------------------------------------------------------------

 91620 22-NOV-13 e0 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M M M M M M F F F F F

 91628 20-NOV-13 e0 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M F M M M M M M M F F F F F F

 91631 20-NOV-13 e3 m4 m4 m4 m4 m4 m4 e2 m4 m4 m4 m4 m4 m4 m4

 M M M M M M M M M F F F F F F

 91636 21-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M F F F F F F F F F

 91649 19-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M M M F F F F F F F F F F

 91650 19-NOV-13 e0 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M M M M M F F F F F F

 91656 24-NOV-13 e0 s1 m4 m4 s1 m4 m4 m4 m4 m4 m4 m4 m4 s3 m4

 F M M M M M M F F F F F F F F

 91671 24-NOV-13 e0 e0 m4 m4 m4 m4 s1 m4 m4 m4 e1 m4 m4 m4 m4

 M F M M M M M M M F F F F F F

 91675 20-NOV-13 m4 m4 m4 e1 m4 m4 m4 m4 m4 m4 e4 m4 m4 s2

 M M M M M F F F F F F F F F

-----------------------------------------------------------------------------------------------------------------------------------

A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4, M = MALE, F = FEMALE, U = UNDETERMINED

e = FOUND DEAD, m = SCHEDULED EUTHANASIA, s = MISSING

Page 928 of 1107
 TABLE A52 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP VIABILITY

--------------------------------------------------------

 LITTERS FROM GROUP 3: 100 PPM

--------------------------------------------------------

 DAY OF

 DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

-----------------------------------------------------------------------------------------------------------------------------------

 91677 21-NOV-13 e3 m4 m4 s3 m4

 M M F F F

 91679 19-NOV-13 e0 e0 m4 m4 m4 s2 m4 m4 m4 e2 e1 m4

 M F M M M M M M F F F F

 91684 20-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M M M M M M F F F F F F F

-----------------------------------------------------------------------------------------------------------------------------------

A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4, M = MALE, F = FEMALE, U = UNDETERMINED

Page 929 of 1107

e = FOUND DEAD, m = SCHEDULED EUTHANASIA, s = MISSING
 TABLE A52 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP VIABILITY

--------------------------------------------------------

 LITTERS FROM GROUP 4: 175 PPM

--------------------------------------------------------

 DAY OF

 DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

-----------------------------------------------------------------------------------------------------------------------------------

 91622 19-NOV-13 e1 e1 e1 m4 m4 m4 m4 e2 m4 m4 m4 m4 e2 e3

 M M F M M M M M M M F F F F

 91626 22-NOV-13 e1 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 F M M M M M M F F F F F F F

 91643 25-NOV-13 e1 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M M M M M M F F F

 91654 25-NOV-13 e0 e0 e1 e2 e2 s2 e2 e2 e2 e1 s2 e2 s2 e2 s2 s2 e2 s2

 F M M M M M M M M M M M M F F F F F

 91657 30-NOV-13 e2 e2 e2 m4 m4 m4 e2 e2 m4 m4 m4 m4 m4

 F M M M M M M F F F F F F

 91662 22-NOV-13 e0 e0 m4 m4 m4 m4 s2 s3 m4 m4 m4

 M F M M M M F F F F F

 91666 20-NOV-13 e1 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 F M M M M M M M F F F

 91676 21-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 s1 m4

 M M M M M F F F F F F

 91678 20-NOV-13 m4 m4 m4 m4 e4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M F F F F F F F F F F

-----------------------------------------------------------------------------------------------------------------------------------

A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4, M = MALE, F = FEMALE, U = UNDETERMINED

e = FOUND DEAD, m = SCHEDULED EUTHANASIA, s = MISSING

Page 930 of 1107
 TABLE A52 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP VIABILITY

--------------------------------------------------------

 LITTERS FROM GROUP 4: 175 PPM

--------------------------------------------------------

 DAY OF

 DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

-----------------------------------------------------------------------------------------------------------------------------------

 91681 29-NOV-13 e0 e0 s1 m4 m4 m4 s2 e1 m4 m4 m4 m4 m4 m4 m4

 F F M M M M M M M M F F F F F

 91682 22-NOV-13 e0 s3 s1 m4 s2 m4 s2 m4 s3 s2 m4 m4 s2

 F F M M M M M M M M M F F

-----------------------------------------------------------------------------------------------------------------------------------

A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4, M = MALE, F = FEMALE, U = UNDETERMINED

e = FOUND DEAD, m = SCHEDULED EUTHANASIA, s = MISSING

Page 931 of 1107
 TABLE A52 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP VIABILITY

--------------------------------------------------------

 LITTERS FROM GROUP 5: 10000 PPM

--------------------------------------------------------

 DAY OF

 DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

-----------------------------------------------------------------------------------------------------------------------------------

 91624 21-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M M M M M F F F F F

 91625 22-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M M F F F F F F F F F

 91627 19-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M M M M M F F F F F

 91634 22-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M M M F F F F F F F

 91635 19-NOV-13 e0 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M M M M F F F F F F

 91638 21-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M M M M M M F F F F F F F

 91652 19-NOV-13 e0 a0 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M U M M M M M M M M F F F

 91655 19-NOV-13 m4 m4 m4 m4 m4 m4 m4 e2 m4 m4 m4 m4 e1

 M M M M F F F F F F F F F

 91658 20-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M M M M M F F F F F

-----------------------------------------------------------------------------------------------------------------------------------

A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4, M = MALE, F = FEMALE, U = UNDETERMINED

a = FOUND DEAD; PARTIALLY CANNIBALIZED, e = FOUND DEAD, m = SCHEDULED EUTHANASIA

Page 932 of 1107
 TABLE A52 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP VIABILITY

--------------------------------------------------------

 LITTERS FROM GROUP 5: 10000 PPM

--------------------------------------------------------

 DAY OF

 DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

-----------------------------------------------------------------------------------------------------------------------------------

 91667 20-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M M F F F F F F F F F F F

 91668 20-NOV-13 a0 e0 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 U M M M M M M M M M M F F F F

 91680 19-NOV-13 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4 m4

 M M M M M M M F F F F F F F F

-----------------------------------------------------------------------------------------------------------------------------------

A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4, M = MALE, F = FEMALE, U = UNDETERMINED

a = FOUND DEAD; PARTIALLY CANNIBALIZED, e = FOUND DEAD, m = SCHEDULED EUTHANASIA

 PLITRv4.05

 02/18/2014

Page 933 of 1107
 TABLE A53 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL POSTNATAL SURVIVAL (% PER LITTER)

--------------------------------------------

 LITTERS FROM GROUP 1: 0 PPM

--------------------------------------------

 ANIMAL B 0- 1 1- 4 B- 4

-----------------------------------------------------------------------------------------------------------------------------------

 91629 100.0 100.0 93.8 93.8

 91630 85.7 100.0 100.0 85.7

 91633 100.0 100.0 100.0 100.0

 91637 100.0 100.0 92.3 92.3

 91639 100.0 90.0 100.0 90.0

 91644 100.0 100.0 94.1 94.1

 91645 93.8 100.0 100.0 93.8

 91648 92.9 100.0 100.0 92.9

 91653 100.0 100.0 100.0 100.0

 91660 92.9 100.0 100.0 92.9

 91670 100.0 100.0 100.0 100.0

 91672 92.9 100.0 84.6 78.6

 MEAN 96.5 99.2 97.1 92.8

 S.D. 4.76 2.89 4.92 6.18

 S.E. 1.37 0.83 1.42 1.78

 N 12 12 12 12

B= BIRTH

Page 934 of 1107
 TABLE A53 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL POSTNATAL SURVIVAL (% PER LITTER)

--------------------------------------------

 LITTERS FROM GROUP 2: 50 PPM

--------------------------------------------

 ANIMAL B 0- 1 1- 4 B- 4

-----------------------------------------------------------------------------------------------------------------------------------

 91632 100.0 100.0 93.3 93.3

 91640 83.3 100.0 100.0 83.3

 91642 100.0 100.0 100.0 100.0

 91647 92.3 91.7 100.0 84.6

 91651 100.0 100.0 100.0 100.0

 91659 100.0 92.3 100.0 92.3

 91661 100.0 100.0 100.0 100.0

 91663 100.0 93.3 92.9 86.7

 91669 100.0 100.0 75.0 75.0

 91673 100.0 100.0 100.0 100.0

 91683 100.0 100.0 100.0 100.0

 91685 100.0 100.0 90.0 90.0

 MEAN 98.0 98.1 95.9 92.1

 S.D. 5.11 3.44 7.52 8.38

 S.E. 1.48 0.99 2.17 2.42

 N 12 12 12 12

B= BIRTH

Page 935 of 1107
 TABLE A53 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL POSTNATAL SURVIVAL (% PER LITTER)

--------------------------------------------

 LITTERS FROM GROUP 3: 100 PPM

--------------------------------------------

 ANIMAL B 0- 1 1- 4 B- 4

-----------------------------------------------------------------------------------------------------------------------------------

 91620 92.9 100.0 100.0 92.9

 91628 93.3 100.0 100.0 93.3

 91631 100.0 100.0 86.7 86.7

 91636 100.0 100.0 100.0 100.0

 91649 100.0 100.0 100.0 100.0

 91650 92.9 100.0 100.0 92.9

 91656 93.3 85.7 91.7 73.3

 91671 86.7 84.6 100.0 73.3

 91675 100.0 92.9 84.6 78.6

 91677 100.0 100.0 60.0 60.0

 91679 83.3 90.0 77.8 58.3

 91684 100.0 100.0 100.0 100.0

 MEAN 95.2 96.1 91.7 84.1

 S.D. 5.80 6.10 12.64 15.11

 S.E. 1.67 1.76 3.65 4.36

 N 12 12 12 12

B= BIRTH

Page 936 of 1107
 TABLE A53 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL POSTNATAL SURVIVAL (% PER LITTER)

--------------------------------------------

 LITTERS FROM GROUP 4: 175 PPM

--------------------------------------------

 ANIMAL B 0- 1 1- 4 B- 4

-----------------------------------------------------------------------------------------------------------------------------------

 91622 100.0 78.6 72.7 57.1

 91626 100.0 92.9 100.0 92.9

 91643 100.0 91.7 100.0 91.7

 91654 88.9 87.5 0.0 0.0

 91657 100.0 100.0 61.5 61.5

 91662 81.8 100.0 77.8 63.6

 91666 100.0 90.9 100.0 90.9

 91676 100.0 90.9 100.0 90.9

 91678 100.0 100.0 92.9 92.9

 91681 86.7 84.6 90.9 66.7

 91682 92.3 91.7 45.5 38.5

 MEAN 95.4 91.7 76.5 67.9

 S.D. 6.79 6.70 31.21 29.19

 S.E. 2.05 2.02 9.41 8.80

 N 11 11 11 11

B= BIRTH

Page 937 of 1107
 TABLE A53 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL POSTNATAL SURVIVAL (% PER LITTER)

--------------------------------------------

 LITTERS FROM GROUP 5: 10000 PPM

--------------------------------------------

 ANIMAL B 0- 1 1- 4 B- 4

-----------------------------------------------------------------------------------------------------------------------------------

 91624 100.0 100.0 100.0 100.0

 91625 100.0 100.0 100.0 100.0

 91627 100.0 100.0 100.0 100.0

 91634 100.0 100.0 100.0 100.0

 91635 92.3 100.0 100.0 92.3

 91638 100.0 100.0 100.0 100.0

 91652 84.6 100.0 100.0 84.6

 91655 100.0 92.3 91.7 84.6

 91658 100.0 100.0 100.0 100.0

 91667 100.0 100.0 100.0 100.0

 91668 86.7 100.0 100.0 86.7

 91680 100.0 100.0 100.0 100.0

 MEAN 97.0 99.4 99.3 95.7

 S.D. 5.75 2.22 2.41 6.65

 S.E. 1.66 0.64 0.69 1.92

 N 12 12 12 12

B= BIRTH

 PPVIASv5.12

 02/18/2014

Page 938 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91629-01 M 0 PPM NORMAL 1 11/22/13 12:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91629-01 M 0 PPM DISPOSITION 4 11/25/13 9:31 P SCHEDULED EUTHANASIA

 91629-02 M 0 PPM NORMAL 1 11/22/13 12:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91629-02 M 0 PPM DISPOSITION 4 11/25/13 9:31 P SCHEDULED EUTHANASIA

 91629-03 M 0 PPM NORMAL 1 11/22/13 12:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91629-03 M 0 PPM DISPOSITION 4 11/25/13 9:31 P SCHEDULED EUTHANASIA

 91629-04 M 0 PPM NORMAL 1 11/22/13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91629-04 M 0 PPM DISPOSITION 4 11/25/13 9:31 P SCHEDULED EUTHANASIA

 91629-05 M 0 PPM NORMAL 1 11/22/13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91629-05 M 0 PPM DISPOSITION 4 11/25/13 9:31 P SCHEDULED EUTHANASIA

 91629-06 M 0 PPM NORMAL 1 11/22/13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91629-06 M 0 PPM DISPOSITION 4 11/25/13 9:31 P SCHEDULED EUTHANASIA

 91629-07 M 0 PPM NORMAL 1 11/22/13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91629-07 M 0 PPM DISPOSITION 2 11/23/13 8:22 P FOUND DEAD

 91629-08 M 0 PPM NORMAL 1 11/22/13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91629-08 M 0 PPM DISPOSITION 4 11/25/13 9:31 P SCHEDULED EUTHANASIA

 91629-09 M 0 PPM NORMAL 1 11/22/13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91629-09 M 0 PPM DISPOSITION 4 11/25/13 9:31 P SCHEDULED EUTHANASIA

 91629-10 M 0 PPM NORMAL 1 11/22/13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91629-10 M 0 PPM DISPOSITION 4 11/25/13 9:31 P SCHEDULED EUTHANASIA

 91629-11 M 0 PPM NORMAL 1 11/22/13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 939 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91629-11 M 0 PPM NORMAL 4 11/25/13 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91629-11 M 0 PPM DISPOSITION 4 11/25/13 9:31 P SCHEDULED EUTHANASIA

 91629-12 M 0 PPM NORMAL 1 11/22/13 12:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91629-12 M 0 PPM DISPOSITION 4 11/25/13 9:31 P SCHEDULED EUTHANASIA

 91629-13 F 0 PPM NORMAL 1 11/22/13 12:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91629-13 F 0 PPM DISPOSITION 4 11/25/13 9:31 P SCHEDULED EUTHANASIA

 91629-14 F 0 PPM NORMAL 1 11/22/13 12:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91629-14 F 0 PPM DISPOSITION 4 11/25/13 9:31 P SCHEDULED EUTHANASIA

 91629-15 F 0 PPM NORMAL 1 11/22/13 12:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91629-15 F 0 PPM DISPOSITION 4 11/25/13 9:31 P SCHEDULED EUTHANASIA

 91629-16 F 0 PPM NORMAL 1 11/22/13 12:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91629-16 F 0 PPM DISPOSITION 4 11/25/13 9:31 P SCHEDULED EUTHANASIA

 91630-01 M 0 PPM DISPOSITION 0 11/22/13 9:07 P FOUND DEAD

 91630-02 M 0 PPM DISPOSITION 0 11/22/13 9:08 P FOUND DEAD

 91630-03 M 0 PPM NORMAL 1 11/23/13 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91630-03 M 0 PPM DISPOSITION 4 11/26/13 9:47 P SCHEDULED EUTHANASIA

 91630-04 M 0 PPM NORMAL 1 11/23/13 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91630-04 M 0 PPM DISPOSITION 4 11/26/13 9:47 P SCHEDULED EUTHANASIA

 91630-05 M 0 PPM NORMAL 1 11/23/13 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91630-05 M 0 PPM DISPOSITION 4 11/26/13 9:47 P SCHEDULED EUTHANASIA

 91630-06 M 0 PPM NORMAL 1 11/23/13 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 940 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91630-06 M 0 PPM NORMAL 4 11/26/13 9:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91630-06 M 0 PPM DISPOSITION 4 11/26/13 9:47 P SCHEDULED EUTHANASIA

 91630-07 M 0 PPM NORMAL 1 11/23/13 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91630-07 M 0 PPM DISPOSITION 4 11/26/13 9:47 P SCHEDULED EUTHANASIA

 91630-08 M 0 PPM NORMAL 1 11/23/13 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91630-08 M 0 PPM DISPOSITION 4 11/26/13 9:47 P SCHEDULED EUTHANASIA

 91630-09 F 0 PPM NORMAL 1 11/23/13 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91630-09 F 0 PPM DISPOSITION 4 11/26/13 9:47 P SCHEDULED EUTHANASIA

 91630-10 F 0 PPM NORMAL 1 11/23/13 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91630-10 F 0 PPM DISPOSITION 4 11/26/13 9:47 P SCHEDULED EUTHANASIA

 91630-11 F 0 PPM NORMAL 1 11/23/13 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91630-11 F 0 PPM DISPOSITION 4 11/26/13 9:47 P SCHEDULED EUTHANASIA

 91630-12 F 0 PPM NORMAL 1 11/23/13 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91630-12 F 0 PPM DISPOSITION 4 11/26/13 9:48 P SCHEDULED EUTHANASIA

 91630-13 F 0 PPM NORMAL 1 11/23/13 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91630-13 F 0 PPM DISPOSITION 4 11/26/13 9:48 P SCHEDULED EUTHANASIA

 91630-14 F 0 PPM NORMAL 1 11/23/13 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91630-14 F 0 PPM DISPOSITION 4 11/26/13 9:48 P SCHEDULED EUTHANASIA

 91633-01 M 0 PPM NORMAL 1 11/20/13 11:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91633-01 M 0 PPM DISPOSITION 4 11/23/13 11:59 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 941 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91633-02 M 0 PPM NORMAL 1 11/20/13 11:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91633-02 M 0 PPM DISPOSITION 4 11/23/13 11:59 P SCHEDULED EUTHANASIA

 91633-03 M 0 PPM NORMAL 1 11/20/13 11:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91633-03 M 0 PPM DISPOSITION 4 11/23/13 11:59 P SCHEDULED EUTHANASIA

 91633-04 M 0 PPM NORMAL 1 11/20/13 11:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91633-04 M 0 PPM DISPOSITION 4 11/23/13 11:59 P SCHEDULED EUTHANASIA

 91633-05 M 0 PPM NORMAL 1 11/20/13 11:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91633-05 M 0 PPM DISPOSITION 4 11/23/13 12:00 P SCHEDULED EUTHANASIA

 91633-06 M 0 PPM NORMAL 1 11/20/13 11:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91633-06 M 0 PPM DISPOSITION 4 11/23/13 12:00 P SCHEDULED EUTHANASIA

 91633-07 M 0 PPM NORMAL 1 11/20/13 11:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91633-07 M 0 PPM DISPOSITION 4 11/23/13 12:00 P SCHEDULED EUTHANASIA

 91633-08 F 0 PPM NORMAL 1 11/20/13 11:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91633-08 F 0 PPM DISPOSITION 4 11/23/13 12:00 P SCHEDULED EUTHANASIA

 91633-09 F 0 PPM NORMAL 1 11/20/13 11:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91633-09 F 0 PPM DISPOSITION 4 11/23/13 12:00 P SCHEDULED EUTHANASIA

 91633-10 F 0 PPM NORMAL 1 11/20/13 11:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91633-10 F 0 PPM DISPOSITION 4 11/23/13 12:00 P SCHEDULED EUTHANASIA

 91633-11 F 0 PPM NORMAL 1 11/20/13 11:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91633-11 F 0 PPM DISPOSITION 4 11/23/13 12:01 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 942 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91633-12 F 0 PPM NORMAL 1 11/20/13 11:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91633-12 F 0 PPM DISPOSITION 4 11/23/13 12:01 P SCHEDULED EUTHANASIA

 91633-13 F 0 PPM NORMAL 1 11/20/13 11:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91633-13 F 0 PPM DISPOSITION 4 11/23/13 12:01 P SCHEDULED EUTHANASIA

 91633-14 F 0 PPM NORMAL 1 11/20/13 11:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91633-14 F 0 PPM DISPOSITION 4 11/23/13 12:01 P SCHEDULED EUTHANASIA

 91633-15 F 0 PPM NORMAL 1 11/20/13 11:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91633-15 F 0 PPM DISPOSITION 4 11/23/13 12:01 P SCHEDULED EUTHANASIA

 91637-01 M 0 PPM NORMAL 1 11/19/13 9:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/22/13 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91637-01 M 0 PPM DISPOSITION 4 11/22/13 12:44 P SCHEDULED EUTHANASIA

 91637-02 M 0 PPM NORMAL 1 11/19/13 9:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/22/13 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91637-02 M 0 PPM DISPOSITION 4 11/22/13 12:45 P SCHEDULED EUTHANASIA

 91637-03 M 0 PPM NORMAL 1 11/19/13 9:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/22/13 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91637-03 M 0 PPM DISPOSITION 4 11/22/13 12:45 P SCHEDULED EUTHANASIA

 91637-04 M 0 PPM NORMAL 1 11/19/13 9:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS *

 4 11/22/13 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91637-04 M 0 PPM DISPOSITION 4 11/22/13 12:45 P SCHEDULED EUTHANASIA

 91637-05 M 0 PPM DISPOSITION 3 11/21/13 10:42 P FOUND DEAD

 91637-05 M 0 PPM BODY/INTEGUMENT 1 11/19/13 9:29 P SMALL STATURE

 91637-06 F 0 PPM NORMAL 1 11/19/13 9:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/22/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91637-06 F 0 PPM DISPOSITION 4 11/22/13 12:45 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

 * - LATE COMPUTER ENTRY OBSERVATIONS FOR ABOVE DATES

Page 943 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91637-07 F 0 PPM NORMAL 1 11/19/13 9:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/22/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91637-07 F 0 PPM DISPOSITION 4 11/22/13 12:45 P SCHEDULED EUTHANASIA

 91637-08 F 0 PPM NORMAL 1 11/19/13 9:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/22/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91637-08 F 0 PPM DISPOSITION 4 11/22/13 12:45 P SCHEDULED EUTHANASIA

 91637-09 F 0 PPM NORMAL 1 11/19/13 9:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/22/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91637-09 F 0 PPM DISPOSITION 4 11/22/13 12:45 P SCHEDULED EUTHANASIA

 91637-10 F 0 PPM NORMAL 1 11/19/13 9:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/22/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91637-10 F 0 PPM DISPOSITION 4 11/22/13 12:45 P SCHEDULED EUTHANASIA

 91637-11 F 0 PPM NORMAL 1 11/19/13 9:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/22/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91637-11 F 0 PPM DISPOSITION 4 11/22/13 12:45 P SCHEDULED EUTHANASIA

 91637-12 F 0 PPM NORMAL 1 11/19/13 9:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/22/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91637-12 F 0 PPM DISPOSITION 4 11/22/13 12:45 P SCHEDULED EUTHANASIA

 91637-13 F 0 PPM NORMAL 1 11/19/13 9:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/22/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91637-13 F 0 PPM DISPOSITION 4 11/22/13 12:45 P SCHEDULED EUTHANASIA

 91639-01 M 0 PPM DISPOSITION 1 11/22/13 12:47 P FOUND DEAD

 91639-01 M 0 PPM BODY/INTEGUMENT 0 11/21/13 13:52 P BODY PALE

 0 11/21/13 13:52 P BODY COOL

 91639-01 M 0 PPM CARDIO-PULMONARY 0 11/21/13 13:52 P GASPING

 91639-02 M 0 PPM NORMAL 1 11/22/13 12:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91639-02 M 0 PPM DISPOSITION 4 11/25/13 9:33 P SCHEDULED EUTHANASIA

 91639-03 M 0 PPM NORMAL 1 11/22/13 12:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 944 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91639-03 M 0 PPM NORMAL 4 11/25/13 8:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91639-03 M 0 PPM DISPOSITION 4 11/25/13 9:33 P SCHEDULED EUTHANASIA

 91639-04 M 0 PPM NORMAL 1 11/22/13 12:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91639-04 M 0 PPM DISPOSITION 4 11/25/13 9:33 P SCHEDULED EUTHANASIA

 91639-05 M 0 PPM NORMAL 1 11/22/13 12:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91639-05 M 0 PPM DISPOSITION 4 11/25/13 9:33 P SCHEDULED EUTHANASIA

 91639-06 M 0 PPM NORMAL 1 11/22/13 12:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91639-06 M 0 PPM DISPOSITION 4 11/25/13 9:33 P SCHEDULED EUTHANASIA

 91639-07 M 0 PPM NORMAL 1 11/22/13 12:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91639-07 M 0 PPM DISPOSITION 4 11/25/13 9:33 P SCHEDULED EUTHANASIA

 91639-08 M 0 PPM NORMAL 1 11/22/13 12:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91639-08 M 0 PPM DISPOSITION 4 11/25/13 9:33 P SCHEDULED EUTHANASIA

 91639-09 F 0 PPM NORMAL 1 11/22/13 12:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91639-09 F 0 PPM DISPOSITION 4 11/25/13 9:33 P SCHEDULED EUTHANASIA

 91639-10 F 0 PPM NORMAL 1 11/22/13 12:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91639-10 F 0 PPM DISPOSITION 4 11/25/13 9:33 P SCHEDULED EUTHANASIA

 91644-01 M 0 PPM NORMAL 1 11/20/13 11:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91644-01 M 0 PPM DISPOSITION 4 11/23/13 12:06 P SCHEDULED EUTHANASIA

 91644-02 M 0 PPM NORMAL 1 11/20/13 11:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91644-02 M 0 PPM DISPOSITION 4 11/23/13 12:06 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 945 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91644-03 M 0 PPM NORMAL 1 11/20/13 11:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91644-03 M 0 PPM DISPOSITION 4 11/23/13 12:06 P SCHEDULED EUTHANASIA

 91644-04 M 0 PPM NORMAL 1 11/20/13 11:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91644-04 M 0 PPM DISPOSITION 4 11/23/13 12:06 P SCHEDULED EUTHANASIA

 91644-05 M 0 PPM NORMAL 1 11/20/13 11:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91644-05 M 0 PPM DISPOSITION 4 11/23/13 12:06 P SCHEDULED EUTHANASIA

 91644-06 M 0 PPM NORMAL 1 11/20/13 11:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91644-06 M 0 PPM DISPOSITION 4 11/23/13 12:06 P SCHEDULED EUTHANASIA

 91644-07 M 0 PPM NORMAL 1 11/20/13 11:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91644-07 M 0 PPM DISPOSITION 4 11/23/13 12:06 P SCHEDULED EUTHANASIA

 91644-08 M 0 PPM NORMAL 1 11/20/13 11:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91644-08 M 0 PPM DISPOSITION 4 11/23/13 12:06 P SCHEDULED EUTHANASIA

 91644-09 M 0 PPM NORMAL 1 11/20/13 11:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91644-09 M 0 PPM DISPOSITION 4 11/23/13 12:07 P SCHEDULED EUTHANASIA

 91644-10 M 0 PPM NORMAL 1 11/20/13 11:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91644-10 M 0 PPM DISPOSITION 4 11/23/13 12:07 P SCHEDULED EUTHANASIA

 91644-11 F 0 PPM NORMAL 1 11/20/13 11:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91644-11 F 0 PPM DISPOSITION 4 11/23/13 12:07 P SCHEDULED EUTHANASIA

 91644-12 F 0 PPM NORMAL 1 11/20/13 11:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91644-12 F 0 PPM DISPOSITION 4 11/23/13 12:07 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 946 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91644-13 F 0 PPM NORMAL 1 11/20/13 11:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91644-13 F 0 PPM DISPOSITION 4 11/23/13 12:07 P SCHEDULED EUTHANASIA

 91644-14 F 0 PPM NORMAL 1 11/20/13 11:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91644-14 F 0 PPM DISPOSITION 4 11/23/13 12:07 P SCHEDULED EUTHANASIA

 91644-15 F 0 PPM NORMAL 1 11/20/13 11:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91644-15 F 0 PPM DISPOSITION 4 11/23/13 12:07 P SCHEDULED EUTHANASIA

 91644-16 F 0 PPM NORMAL 1 11/20/13 11:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91644-16 F 0 PPM DISPOSITION 4 11/23/13 12:10 P SCHEDULED EUTHANASIA

 91644-17 F 0 PPM NORMAL 1 11/20/13 11:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91644-17 F 0 PPM DISPOSITION 4 11/23/13 8:33 P MISSING

 91645-01 M 0 PPM NORMAL 1 11/23/13 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91645-01 M 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA

 91645-02 M 0 PPM NORMAL 1 11/23/13 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91645-02 M 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA

 91645-03 M 0 PPM NORMAL 1 11/23/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91645-03 M 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA

 91645-04 M 0 PPM NORMAL 1 11/23/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91645-04 M 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA

 91645-05 M 0 PPM NORMAL 1 11/23/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91645-05 M 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 947 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91645-06 M 0 PPM NORMAL 1 11/23/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91645-06 M 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA

 91645-07 M 0 PPM NORMAL 1 11/23/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91645-07 M 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA

 91645-08 M 0 PPM DISPOSITION 0 11/22/13 13:39 P FOUND DEAD-A

 91645-09 M 0 PPM NORMAL 1 11/23/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91645-09 M 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA

 91645-10 F 0 PPM NORMAL 1 11/23/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91645-10 F 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA

 91645-11 F 0 PPM NORMAL 1 11/23/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91645-11 F 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA

 91645-12 F 0 PPM NORMAL 1 11/23/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91645-12 F 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA

 91645-13 F 0 PPM NORMAL 1 11/23/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91645-13 F 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA

 91645-14 F 0 PPM NORMAL 1 11/23/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91645-14 F 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA

 91645-15 F 0 PPM NORMAL 1 11/23/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91645-15 F 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA

 91645-16 F 0 PPM NORMAL 1 11/23/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

A = PUP FOUND DEAD ON PND 0, BUT HAD MILK IN STOMACH; PUP CONSIDERED BORN ALIVE.

Page 948 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 11

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91645-16 F 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA

 91648-01 M 0 PPM DISPOSITION 0 11/19/13 13:54 P FOUND DEAD

 91648-02 M 0 PPM NORMAL 1 11/20/13 11:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91648-02 M 0 PPM DISPOSITION 4 11/23/13 12:13 P SCHEDULED EUTHANASIA

 91648-03 M 0 PPM NORMAL 1 11/20/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91648-03 M 0 PPM DISPOSITION 4 11/23/13 12:13 P SCHEDULED EUTHANASIA

 91648-04 M 0 PPM NORMAL 1 11/20/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91648-04 M 0 PPM DISPOSITION 4 11/23/13 12:13 P SCHEDULED EUTHANASIA

 91648-05 M 0 PPM NORMAL 1 11/20/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91648-05 M 0 PPM DISPOSITION 4 11/23/13 12:13 P SCHEDULED EUTHANASIA

 91648-06 M 0 PPM NORMAL 1 11/20/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91648-06 M 0 PPM DISPOSITION 4 11/23/13 12:13 P SCHEDULED EUTHANASIA

 91648-07 M 0 PPM NORMAL 1 11/20/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91648-07 M 0 PPM DISPOSITION 4 11/23/13 12:13 P SCHEDULED EUTHANASIA

 91648-08 M 0 PPM NORMAL 1 11/20/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91648-08 M 0 PPM DISPOSITION 4 11/23/13 12:13 P SCHEDULED EUTHANASIA

 91648-09 M 0 PPM NORMAL 1 11/20/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91648-09 M 0 PPM DISPOSITION 4 11/23/13 12:13 P SCHEDULED EUTHANASIA

 91648-10 F 0 PPM NORMAL 1 11/20/13 11:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91648-10 F 0 PPM DISPOSITION 4 11/23/13 12:13 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 949 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 12

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91648-11 F 0 PPM NORMAL 1 11/20/13 11:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91648-11 F 0 PPM DISPOSITION 4 11/23/13 12:13 P SCHEDULED EUTHANASIA

 91648-12 F 0 PPM NORMAL 1 11/20/13 11:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91648-12 F 0 PPM DISPOSITION 4 11/23/13 12:13 P SCHEDULED EUTHANASIA

 91648-13 F 0 PPM NORMAL 1 11/20/13 11:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91648-13 F 0 PPM DISPOSITION 4 11/23/13 12:13 P SCHEDULED EUTHANASIA

 91648-14 F 0 PPM NORMAL 1 11/20/13 11:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91648-14 F 0 PPM DISPOSITION 4 11/23/13 12:13 P SCHEDULED EUTHANASIA

 91653-01 M 0 PPM NORMAL 1 11/22/13 12:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91653-01 M 0 PPM DISPOSITION 4 11/25/13 9:35 P SCHEDULED EUTHANASIA

 91653-02 M 0 PPM NORMAL 1 11/22/13 12:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91653-02 M 0 PPM DISPOSITION 4 11/25/13 9:35 P SCHEDULED EUTHANASIA

 91653-03 M 0 PPM NORMAL 1 11/22/13 12:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91653-03 M 0 PPM DISPOSITION 4 11/25/13 9:35 P SCHEDULED EUTHANASIA

 91653-04 M 0 PPM NORMAL 1 11/22/13 12:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91653-04 M 0 PPM DISPOSITION 4 11/25/13 9:35 P SCHEDULED EUTHANASIA

 91653-05 M 0 PPM NORMAL 1 11/22/13 12:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91653-05 M 0 PPM DISPOSITION 4 11/25/13 9:35 P SCHEDULED EUTHANASIA

 91653-06 M 0 PPM NORMAL 1 11/22/13 12:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 950 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 13

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91653-06 M 0 PPM DISPOSITION 4 11/25/13 9:35 P SCHEDULED EUTHANASIA

 91653-07 F 0 PPM NORMAL 1 11/22/13 12:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91653-07 F 0 PPM DISPOSITION 4 11/25/13 9:35 P SCHEDULED EUTHANASIA

 91653-08 F 0 PPM NORMAL 1 11/22/13 12:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91653-08 F 0 PPM DISPOSITION 4 11/25/13 9:35 P SCHEDULED EUTHANASIA

 91653-09 F 0 PPM NORMAL 1 11/22/13 12:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91653-09 F 0 PPM DISPOSITION 4 11/25/13 9:35 P SCHEDULED EUTHANASIA

 91653-10 F 0 PPM NORMAL 1 11/22/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91653-10 F 0 PPM DISPOSITION 4 11/25/13 9:35 P SCHEDULED EUTHANASIA

 91653-11 F 0 PPM NORMAL 1 11/22/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91653-11 F 0 PPM DISPOSITION 4 11/25/13 9:35 P SCHEDULED EUTHANASIA

 91653-12 F 0 PPM NORMAL 1 11/22/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91653-12 F 0 PPM DISPOSITION 4 11/25/13 9:35 P SCHEDULED EUTHANASIA

 91653-13 F 0 PPM NORMAL 1 11/22/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91653-13 F 0 PPM DISPOSITION 4 11/25/13 9:35 P SCHEDULED EUTHANASIA

 91653-14 F 0 PPM NORMAL 1 11/22/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91653-14 F 0 PPM DISPOSITION 4 11/25/13 9:35 P SCHEDULED EUTHANASIA

 91653-15 F 0 PPM NORMAL 1 11/22/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91653-15 F 0 PPM DISPOSITION 4 11/25/13 9:35 P SCHEDULED EUTHANASIA

 91660-01 M 0 PPM DISPOSITION 0 11/21/13 13:56 P FOUND DEAD

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 951 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 14

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91660-02 M 0 PPM NORMAL 1 11/22/13 12:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91660-02 M 0 PPM DISPOSITION 4 11/25/13 9:37 P SCHEDULED EUTHANASIA

 91660-03 M 0 PPM NORMAL 1 11/22/13 12:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91660-03 M 0 PPM DISPOSITION 4 11/25/13 9:37 P SCHEDULED EUTHANASIA

 91660-04 M 0 PPM NORMAL 1 11/22/13 12:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91660-04 M 0 PPM DISPOSITION 4 11/25/13 9:37 P SCHEDULED EUTHANASIA

 91660-05 M 0 PPM NORMAL 1 11/22/13 12:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91660-05 M 0 PPM DISPOSITION 4 11/25/13 9:37 P SCHEDULED EUTHANASIA

 91660-06 M 0 PPM NORMAL 1 11/22/13 12:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91660-06 M 0 PPM DISPOSITION 4 11/25/13 9:37 P SCHEDULED EUTHANASIA

 91660-07 M 0 PPM NORMAL 1 11/22/13 12:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91660-07 M 0 PPM DISPOSITION 4 11/25/13 9:37 P SCHEDULED EUTHANASIA

 91660-08 M 0 PPM NORMAL 1 11/22/13 12:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91660-08 M 0 PPM DISPOSITION 4 11/25/13 9:37 P SCHEDULED EUTHANASIA

 91660-09 M 0 PPM NORMAL 1 11/22/13 12:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91660-09 M 0 PPM DISPOSITION 4 11/25/13 9:37 P SCHEDULED EUTHANASIA

 91660-10 F 0 PPM NORMAL 1 11/22/13 12:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91660-10 F 0 PPM DISPOSITION 4 11/25/13 9:37 P SCHEDULED EUTHANASIA

 91660-11 F 0 PPM NORMAL 1 11/22/13 12:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91660-11 F 0 PPM DISPOSITION 4 11/25/13 9:37 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 952 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 15

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91660-12 F 0 PPM NORMAL 1 11/22/13 12:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91660-12 F 0 PPM DISPOSITION 4 11/25/13 9:37 P SCHEDULED EUTHANASIA

 91660-13 F 0 PPM NORMAL 1 11/22/13 12:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91660-13 F 0 PPM DISPOSITION 4 11/25/13 9:37 P SCHEDULED EUTHANASIA

 91660-14 F 0 PPM NORMAL 1 11/22/13 12:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91660-14 F 0 PPM DISPOSITION 4 11/25/13 9:38 P SCHEDULED EUTHANASIA

 91670-01 M 0 PPM NORMAL 1 11/23/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91670-01 M 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA

 91670-02 M 0 PPM NORMAL 1 11/23/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91670-02 M 0 PPM DISPOSITION 4 11/26/13 9:49 P SCHEDULED EUTHANASIA

 91670-03 M 0 PPM NORMAL 1 11/23/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91670-03 M 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA

 91670-04 M 0 PPM NORMAL 1 11/23/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91670-04 M 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA

 91670-05 M 0 PPM NORMAL 1 11/23/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91670-05 M 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA

 91670-06 M 0 PPM NORMAL 1 11/23/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91670-06 M 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA

 91670-07 M 0 PPM NORMAL 1 11/23/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 953 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 16

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91670-07 M 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA

 91670-08 M 0 PPM NORMAL 1 11/23/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91670-08 M 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA

 91670-09 F 0 PPM NORMAL 1 11/23/13 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91670-09 F 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA

 91670-10 F 0 PPM NORMAL 1 11/23/13 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91670-10 F 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA

 91670-11 F 0 PPM NORMAL 1 11/23/13 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91670-11 F 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA

 91670-12 F 0 PPM NORMAL 1 11/23/13 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91670-12 F 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA

 91670-13 F 0 PPM NORMAL 1 11/23/13 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91670-13 F 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA

 91670-14 F 0 PPM NORMAL 1 11/23/13 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91670-14 F 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA

 91672-01 F 0 PPM DISPOSITION 0 11/22/13 9:22 P FOUND DEAD

 91672-02 M 0 PPM NORMAL 1 11/23/13 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91672-02 M 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA

 91672-03 M 0 PPM NORMAL 1 11/23/13 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91672-03 M 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 954 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 17

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91672-04 M 0 PPM NORMAL 1 11/23/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91672-04 M 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA

 91672-05 M 0 PPM NORMAL 1 11/23/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91672-05 M 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA

 91672-05 M 0 PPM BODY/INTEGUMENT 4 11/26/13 9:29 P BODY PALE

 91672-06 M 0 PPM NORMAL 1 11/23/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91672-06 M 0 PPM DISPOSITION 4 11/26/13 9:50 P SCHEDULED EUTHANASIA

 91672-07 M 0 PPM NORMAL 1 11/23/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91672-07 M 0 PPM DISPOSITION 4 11/26/13 9:28 P FOUND DEAD

 91672-08 M 0 PPM NORMAL 1 11/23/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91672-08 M 0 PPM DISPOSITION 4 11/26/13 9:51 P SCHEDULED EUTHANASIA

 91672-09 F 0 PPM NORMAL 1 11/23/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91672-09 F 0 PPM DISPOSITION 4 11/26/13 9:51 P SCHEDULED EUTHANASIA

 91672-10 F 0 PPM NORMAL 1 11/23/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91672-10 F 0 PPM DISPOSITION 4 11/26/13 9:51 P SCHEDULED EUTHANASIA

 91672-11 F 0 PPM NORMAL 1 11/23/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91672-11 F 0 PPM DISPOSITION 2 11/24/13 9:37 P FOUND DEAD

 91672-12 F 0 PPM NORMAL 1 11/23/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91672-12 F 0 PPM DISPOSITION 4 11/26/13 9:51 P SCHEDULED EUTHANASIA

 91672-13 F 0 PPM NORMAL 1 11/23/13 8:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91672-13 F 0 PPM DISPOSITION 4 11/26/13 9:51 P SCHEDULED EUTHANASIA

 91672-14 F 0 PPM NORMAL 1 11/23/13 8:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 955 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 18

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91672-14 F 0 PPM DISPOSITION 4 11/26/13 9:51 P SCHEDULED EUTHANASIA

 91632-01 M 50 PPM NORMAL 1 11/24/13 10:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91632-01 M 50 PPM DISPOSITION 4 11/27/13 8:04 P SCHEDULED EUTHANASIA

 91632-02 M 50 PPM NORMAL 1 11/24/13 10:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91632-02 M 50 PPM DISPOSITION 4 11/27/13 8:04 P SCHEDULED EUTHANASIA

 91632-03 M 50 PPM NORMAL 1 11/24/13 10:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91632-03 M 50 PPM DISPOSITION 4 11/27/13 8:04 P SCHEDULED EUTHANASIA

 91632-04 M 50 PPM NORMAL 1 11/24/13 10:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91632-04 M 50 PPM DISPOSITION 4 11/27/13 8:04 P SCHEDULED EUTHANASIA

 91632-05 F 50 PPM NORMAL 1 11/24/13 10:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91632-05 F 50 PPM DISPOSITION 4 11/27/13 8:04 P SCHEDULED EUTHANASIA

 91632-06 F 50 PPM NORMAL 1 11/24/13 10:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91632-06 F 50 PPM DISPOSITION 4 11/27/13 8:04 P SCHEDULED EUTHANASIA

 91632-07 F 50 PPM NORMAL 1 11/24/13 10:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91632-07 F 50 PPM DISPOSITION 4 11/27/13 8:04 P SCHEDULED EUTHANASIA

 91632-08 F 50 PPM NORMAL 1 11/24/13 10:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91632-08 F 50 PPM DISPOSITION 4 11/27/13 8:04 P SCHEDULED EUTHANASIA

 91632-09 F 50 PPM NORMAL 1 11/24/13 10:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91632-09 F 50 PPM DISPOSITION 4 11/27/13 8:04 P SCHEDULED EUTHANASIA

 91632-10 F 50 PPM NORMAL 1 11/24/13 10:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 956 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 19

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91632-10 F 50 PPM NORMAL 4 11/27/13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91632-10 F 50 PPM DISPOSITION 4 11/27/13 8:04 P SCHEDULED EUTHANASIA

 91632-11 F 50 PPM NORMAL 1 11/24/13 10:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91632-11 F 50 PPM DISPOSITION 4 11/27/13 8:04 P SCHEDULED EUTHANASIA

 91632-12 F 50 PPM NORMAL 1 11/24/13 10:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91632-12 F 50 PPM DISPOSITION 4 11/27/13 8:04 P SCHEDULED EUTHANASIA

 91632-13 F 50 PPM NORMAL 1 11/24/13 10:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91632-13 F 50 PPM DISPOSITION 4 11/27/13 8:04 P SCHEDULED EUTHANASIA

 91632-14 F 50 PPM NORMAL 1 11/24/13 10:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91632-14 F 50 PPM DISPOSITION 4 11/27/13 8:04 P SCHEDULED EUTHANASIA

 91632-15 F 50 PPM NORMAL 1 11/24/13 10:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91632-15 F 50 PPM DISPOSITION 2 11/25/13 9:41 P FOUND DEAD

 91640-01 M 50 PPM DISPOSITION 0 11/23/13 13:37 P FOUND DEAD

 91640-02 M 50 PPM DISPOSITION 0 11/23/13 13:39 P FOUND DEAD

 91640-03 F 50 PPM DISPOSITION 4 11/27/13 8:05 P SCHEDULED EUTHANASIA

 91640-03 F 50 PPM BODY/INTEGUMENT 0 11/23/13 13:40 P SMALL STATURE

 1 11/24/13 10:09 P SMALL STATURE

 4 11/27/13 7:58 P SMALL STATURE

 91640-04 M 50 PPM NORMAL 1 11/24/13 10:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91640-04 M 50 PPM DISPOSITION 4 11/27/13 8:05 P SCHEDULED EUTHANASIA

 91640-05 M 50 PPM NORMAL 1 11/24/13 10:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91640-05 M 50 PPM DISPOSITION 4 11/27/13 8:05 P SCHEDULED EUTHANASIA

 91640-06 M 50 PPM NORMAL 1 11/24/13 10:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 957 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 20

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91640-06 M 50 PPM NORMAL 4 11/27/13 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91640-06 M 50 PPM DISPOSITION 4 11/27/13 8:05 P SCHEDULED EUTHANASIA

 91640-07 F 50 PPM NORMAL 1 11/24/13 10:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91640-07 F 50 PPM DISPOSITION 4 11/27/13 8:05 P SCHEDULED EUTHANASIA

 91640-08 F 50 PPM NORMAL 1 11/24/13 10:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91640-08 F 50 PPM DISPOSITION 4 11/27/13 8:05 P SCHEDULED EUTHANASIA

 91640-09 F 50 PPM NORMAL 1 11/24/13 10:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91640-09 F 50 PPM DISPOSITION 4 11/27/13 8:05 P SCHEDULED EUTHANASIA

 91640-10 F 50 PPM NORMAL 1 11/24/13 10:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91640-10 F 50 PPM DISPOSITION 4 11/27/13 8:05 P SCHEDULED EUTHANASIA

 91640-11 F 50 PPM NORMAL 1 11/24/13 10:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91640-11 F 50 PPM DISPOSITION 4 11/27/13 8:05 P SCHEDULED EUTHANASIA

 91640-12 F 50 PPM NORMAL 1 11/24/13 10:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91640-12 F 50 PPM DISPOSITION 4 11/27/13 8:05 P SCHEDULED EUTHANASIA

 91642-01 M 50 PPM NORMAL 1 11/21/13 10:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91642-01 M 50 PPM DISPOSITION 4 11/24/13 10:10 P SCHEDULED EUTHANASIA

 91642-02 M 50 PPM NORMAL 1 11/21/13 10:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91642-02 M 50 PPM DISPOSITION 4 11/24/13 10:11 P SCHEDULED EUTHANASIA

 91642-03 M 50 PPM NORMAL 1 11/21/13 10:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91642-03 M 50 PPM DISPOSITION 4 11/24/13 10:11 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 958 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 21

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91642-04 M 50 PPM NORMAL 1 11/21/13 10:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91642-04 M 50 PPM DISPOSITION 4 11/24/13 10:11 P SCHEDULED EUTHANASIA

 91642-05 F 50 PPM NORMAL 1 11/21/13 10:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91642-05 F 50 PPM DISPOSITION 4 11/24/13 10:11 P SCHEDULED EUTHANASIA

 91642-06 F 50 PPM NORMAL 1 11/21/13 10:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91642-06 F 50 PPM DISPOSITION 4 11/24/13 10:11 P SCHEDULED EUTHANASIA

 91642-07 F 50 PPM NORMAL 1 11/21/13 10:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91642-07 F 50 PPM DISPOSITION 4 11/24/13 10:11 P SCHEDULED EUTHANASIA

 91642-08 F 50 PPM NORMAL 1 11/21/13 10:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91642-08 F 50 PPM DISPOSITION 4 11/24/13 10:11 P SCHEDULED EUTHANASIA

 91642-09 F 50 PPM NORMAL 1 11/21/13 10:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91642-09 F 50 PPM DISPOSITION 4 11/24/13 10:11 P SCHEDULED EUTHANASIA

 91642-10 F 50 PPM NORMAL 1 11/21/13 10:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91642-10 F 50 PPM DISPOSITION 4 11/24/13 10:11 P SCHEDULED EUTHANASIA

 91642-11 F 50 PPM NORMAL 1 11/21/13 10:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91642-11 F 50 PPM DISPOSITION 4 11/24/13 10:11 P SCHEDULED EUTHANASIA

 91642-12 F 50 PPM NORMAL 1 11/21/13 10:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91642-12 F 50 PPM DISPOSITION 4 11/24/13 10:11 P SCHEDULED EUTHANASIA

 91642-12 F 50 PPM BODY/INTEGUMENT 4 11/24/13 8:15 P SMALL STATURE

 91642-13 F 50 PPM NORMAL 1 11/21/13 10:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91642-13 F 50 PPM DISPOSITION 4 11/24/13 10:11 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 959 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 22

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91642-14 F 50 PPM NORMAL 1 11/21/13 10:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91642-14 F 50 PPM DISPOSITION 4 11/24/13 10:11 P SCHEDULED EUTHANASIA

 91642-15 M 50 PPM NORMAL 1 11/21/13 10:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91642-15 M 50 PPM DISPOSITION 4 11/24/13 10:11 P SCHEDULED EUTHANASIA

 91647-01 M 50 PPM DISPOSITION 0 11/22/13 13:49 P FOUND DEAD

 91647-02 M 50 PPM DISPOSITION 1 11/23/13 8:50 P MISSING

 91647-02 M 50 PPM BODY/INTEGUMENT 0 11/22/13 13:50 P BODY COOL

 91647-02 M 50 PPM CARDIO-PULMONARY 0 11/22/13 13:51 P GASPING

 91647-03 M 50 PPM NORMAL 1 11/23/13 8:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91647-03 M 50 PPM DISPOSITION 4 11/26/13 9:52 P SCHEDULED EUTHANASIA

 91647-04 M 50 PPM NORMAL 1 11/23/13 8:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91647-04 M 50 PPM DISPOSITION 4 11/26/13 9:52 P SCHEDULED EUTHANASIA

 91647-05 M 50 PPM NORMAL 1 11/23/13 8:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91647-05 M 50 PPM DISPOSITION 4 11/26/13 9:52 P SCHEDULED EUTHANASIA

 91647-06 M 50 PPM NORMAL 1 11/23/13 8:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91647-06 M 50 PPM DISPOSITION 4 11/26/13 9:52 P SCHEDULED EUTHANASIA

 91647-07 M 50 PPM NORMAL 1 11/23/13 8:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91647-07 M 50 PPM DISPOSITION 4 11/26/13 9:52 P SCHEDULED EUTHANASIA

 91647-08 M 50 PPM NORMAL 1 11/23/13 8:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91647-08 M 50 PPM DISPOSITION 4 11/26/13 9:52 P SCHEDULED EUTHANASIA

 91647-09 F 50 PPM NORMAL 1 11/23/13 8:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 960 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 23

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91647-09 F 50 PPM NORMAL 4 11/26/13 9:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91647-09 F 50 PPM DISPOSITION 4 11/26/13 9:52 P SCHEDULED EUTHANASIA

 91647-10 F 50 PPM NORMAL 1 11/23/13 8:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91647-10 F 50 PPM DISPOSITION 4 11/26/13 9:52 P SCHEDULED EUTHANASIA

 91647-11 F 50 PPM NORMAL 1 11/23/13 8:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91647-11 F 50 PPM DISPOSITION 4 11/26/13 9:52 P SCHEDULED EUTHANASIA

 91647-12 F 50 PPM NORMAL 1 11/23/13 8:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91647-12 F 50 PPM DISPOSITION 4 11/26/13 9:52 P SCHEDULED EUTHANASIA

 91647-13 F 50 PPM NORMAL 1 11/23/13 8:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91647-13 F 50 PPM DISPOSITION 4 11/26/13 9:52 P SCHEDULED EUTHANASIA

 91651-01 M 50 PPM NORMAL 1 11/22/13 13:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91651-01 M 50 PPM DISPOSITION 4 11/25/13 9:44 P SCHEDULED EUTHANASIA

 91651-02 M 50 PPM NORMAL 1 11/22/13 13:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91651-02 M 50 PPM DISPOSITION 4 11/25/13 9:44 P SCHEDULED EUTHANASIA

 91651-03 M 50 PPM NORMAL 1 11/22/13 13:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91651-03 M 50 PPM DISPOSITION 4 11/25/13 9:44 P SCHEDULED EUTHANASIA

 91651-04 M 50 PPM NORMAL 1 11/22/13 13:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91651-04 M 50 PPM DISPOSITION 4 11/25/13 9:44 P SCHEDULED EUTHANASIA

 91651-05 M 50 PPM NORMAL 1 11/22/13 13:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91651-05 M 50 PPM DISPOSITION 4 11/25/13 9:44 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 961 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 24

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91651-06 M 50 PPM NORMAL 1 11/22/13 13:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91651-06 M 50 PPM DISPOSITION 4 11/25/13 9:44 P SCHEDULED EUTHANASIA

 91651-07 M 50 PPM NORMAL 1 11/22/13 13:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91651-07 M 50 PPM DISPOSITION 4 11/25/13 9:44 P SCHEDULED EUTHANASIA

 91651-08 F 50 PPM NORMAL 1 11/22/13 13:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91651-08 F 50 PPM DISPOSITION 4 11/25/13 9:44 P SCHEDULED EUTHANASIA

 91651-09 F 50 PPM NORMAL 1 11/22/13 13:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91651-09 F 50 PPM DISPOSITION 4 11/25/13 9:44 P SCHEDULED EUTHANASIA

 91651-10 F 50 PPM NORMAL 1 11/22/13 13:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91651-10 F 50 PPM DISPOSITION 4 11/25/13 9:44 P SCHEDULED EUTHANASIA

 91651-11 F 50 PPM NORMAL 1 11/22/13 13:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91651-11 F 50 PPM DISPOSITION 4 11/25/13 9:44 P SCHEDULED EUTHANASIA

 91651-12 F 50 PPM NORMAL 1 11/22/13 13:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91651-12 F 50 PPM DISPOSITION 4 11/25/13 9:44 P SCHEDULED EUTHANASIA

 91659-01 M 50 PPM DISPOSITION 1 11/21/13 10:55 P FOUND DEAD

 91659-02 M 50 PPM NORMAL 1 11/21/13 10:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91659-02 M 50 PPM DISPOSITION 4 11/24/13 10:12 P SCHEDULED EUTHANASIA

 91659-03 M 50 PPM NORMAL 1 11/21/13 10:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91659-03 M 50 PPM DISPOSITION 4 11/24/13 10:12 P SCHEDULED EUTHANASIA

 91659-04 M 50 PPM NORMAL 1 11/21/13 10:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 962 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 25

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91659-04 M 50 PPM NORMAL 4 11/24/13 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91659-04 M 50 PPM DISPOSITION 4 11/24/13 10:12 P SCHEDULED EUTHANASIA

 91659-05 M 50 PPM NORMAL 1 11/21/13 10:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91659-05 M 50 PPM DISPOSITION 4 11/24/13 10:12 P SCHEDULED EUTHANASIA

 91659-06 M 50 PPM NORMAL 1 11/21/13 10:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91659-06 M 50 PPM DISPOSITION 4 11/24/13 10:12 P SCHEDULED EUTHANASIA

 91659-07 M 50 PPM NORMAL 1 11/21/13 10:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91659-07 M 50 PPM DISPOSITION 4 11/24/13 10:12 P SCHEDULED EUTHANASIA

 91659-08 F 50 PPM NORMAL 1 11/21/13 10:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91659-08 F 50 PPM DISPOSITION 4 11/24/13 10:12 P SCHEDULED EUTHANASIA

 91659-09 F 50 PPM NORMAL 1 11/21/13 10:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91659-09 F 50 PPM DISPOSITION 4 11/24/13 10:13 P SCHEDULED EUTHANASIA

 91659-10 F 50 PPM NORMAL 1 11/21/13 10:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91659-10 F 50 PPM DISPOSITION 4 11/24/13 10:13 P SCHEDULED EUTHANASIA

 91659-11 F 50 PPM NORMAL 1 11/21/13 10:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91659-11 F 50 PPM DISPOSITION 4 11/24/13 10:13 P SCHEDULED EUTHANASIA

 91659-12 F 50 PPM NORMAL 1 11/21/13 10:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91659-12 F 50 PPM DISPOSITION 4 11/24/13 10:13 P SCHEDULED EUTHANASIA

 91659-13 F 50 PPM NORMAL 1 11/21/13 10:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91659-13 F 50 PPM DISPOSITION 4 11/24/13 10:13 P SCHEDULED EUTHANASIA

 91661-01 M 50 PPM NORMAL 1 11/20/13 11:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 963 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 26

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91661-01 M 50 PPM NORMAL 4 11/23/13 8:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91661-01 M 50 PPM DISPOSITION 4 11/23/13 12:17 P SCHEDULED EUTHANASIA

 91661-02 M 50 PPM NORMAL 1 11/20/13 11:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91661-02 M 50 PPM DISPOSITION 4 11/23/13 12:17 P SCHEDULED EUTHANASIA

 91661-03 M 50 PPM NORMAL 1 11/20/13 11:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91661-03 M 50 PPM DISPOSITION 4 11/23/13 12:17 P SCHEDULED EUTHANASIA

 91661-04 M 50 PPM NORMAL 1 11/20/13 11:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91661-04 M 50 PPM DISPOSITION 4 11/23/13 12:17 P SCHEDULED EUTHANASIA

 91661-05 M 50 PPM NORMAL 1 11/20/13 11:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91661-05 M 50 PPM DISPOSITION 4 11/23/13 12:17 P SCHEDULED EUTHANASIA

 91661-06 M 50 PPM NORMAL 1 11/20/13 11:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91661-06 M 50 PPM DISPOSITION 4 11/23/13 12:17 P SCHEDULED EUTHANASIA

 91661-07 M 50 PPM NORMAL 1 11/20/13 11:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91661-07 M 50 PPM DISPOSITION 4 11/23/13 12:17 P SCHEDULED EUTHANASIA

 91661-08 M 50 PPM NORMAL 1 11/20/13 11:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91661-08 M 50 PPM DISPOSITION 4 11/23/13 12:17 P SCHEDULED EUTHANASIA

 91661-09 M 50 PPM NORMAL 1 11/20/13 11:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91661-09 M 50 PPM DISPOSITION 4 11/23/13 12:17 P SCHEDULED EUTHANASIA

 91661-10 M 50 PPM NORMAL 1 11/20/13 11:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91661-10 M 50 PPM DISPOSITION 4 11/23/13 12:17 P SCHEDULED EUTHANASIA

 91661-11 M 50 PPM NORMAL 1 11/20/13 11:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 964 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 27

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91661-11 M 50 PPM NORMAL 4 11/23/13 8:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91661-11 M 50 PPM DISPOSITION 4 11/23/13 12:17 P SCHEDULED EUTHANASIA

 91661-12 F 50 PPM NORMAL 1 11/20/13 11:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91661-12 F 50 PPM DISPOSITION 4 11/23/13 12:17 P SCHEDULED EUTHANASIA

 91661-13 F 50 PPM DISPOSITION 4 11/23/13 12:17 P SCHEDULED EUTHANASIA

 91661-13 F 50 PPM BODY/INTEGUMENT 1 11/20/13 11:40 P SMALL STATURE

 4 11/23/13 8:55 P SMALL STATURE

 91661-14 F 50 PPM NORMAL 1 11/20/13 11:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91661-14 F 50 PPM DISPOSITION 4 11/23/13 12:17 P SCHEDULED EUTHANASIA

 91661-15 F 50 PPM NORMAL 1 11/20/13 11:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91661-15 F 50 PPM DISPOSITION 4 11/23/13 12:17 P SCHEDULED EUTHANASIA

 91661-16 F 50 PPM NORMAL 1 11/20/13 11:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91661-16 F 50 PPM DISPOSITION 4 11/23/13 12:18 P SCHEDULED EUTHANASIA

 91661-17 F 50 PPM NORMAL 1 11/20/13 11:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 8:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91661-17 F 50 PPM DISPOSITION 4 11/23/13 12:18 P SCHEDULED EUTHANASIA

 91663-01 M 50 PPM NORMAL 1 11/22/13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91663-01 M 50 PPM DISPOSITION 4 11/25/13 9:45 P SCHEDULED EUTHANASIA

 91663-02 M 50 PPM DISPOSITION 1 11/22/13 13:05 P FOUND DEAD

 91663-03 M 50 PPM NORMAL 1 11/22/13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91663-03 M 50 PPM DISPOSITION 4 11/25/13 9:45 P SCHEDULED EUTHANASIA

 91663-04 M 50 PPM NORMAL 1 11/22/13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 965 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 28

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91663-04 M 50 PPM DISPOSITION 4 11/25/13 9:45 P SCHEDULED EUTHANASIA

 91663-05 M 50 PPM NORMAL 1 11/22/13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91663-05 M 50 PPM DISPOSITION 4 11/25/13 9:45 P SCHEDULED EUTHANASIA

 91663-06 M 50 PPM NORMAL 1 11/22/13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91663-06 M 50 PPM DISPOSITION 4 11/25/13 9:45 P SCHEDULED EUTHANASIA

 91663-07 M 50 PPM NORMAL 1 11/22/13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91663-07 M 50 PPM DISPOSITION 4 11/25/13 9:45 P SCHEDULED EUTHANASIA

 91663-08 F 50 PPM NORMAL 1 11/22/13 13:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91663-08 F 50 PPM DISPOSITION 4 11/25/13 9:45 P SCHEDULED EUTHANASIA

 91663-09 F 50 PPM NORMAL 1 11/22/13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91663-09 F 50 PPM DISPOSITION 4 11/25/13 9:45 P SCHEDULED EUTHANASIA

 91663-10 F 50 PPM NORMAL 1 11/22/13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91663-10 F 50 PPM DISPOSITION 4 11/25/13 9:45 P SCHEDULED EUTHANASIA

 91663-11 F 50 PPM NORMAL 1 11/22/13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91663-11 F 50 PPM DISPOSITION 4 11/25/13 9:45 P SCHEDULED EUTHANASIA

 91663-12 F 50 PPM NORMAL 1 11/22/13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91663-12 F 50 PPM DISPOSITION 4 11/25/13 9:45 P SCHEDULED EUTHANASIA

 91663-13 F 50 PPM NORMAL 1 11/22/13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91663-13 F 50 PPM DISPOSITION 4 11/25/13 9:45 P SCHEDULED EUTHANASIA

 91663-14 F 50 PPM NORMAL 1 11/22/13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91663-14 F 50 PPM DISPOSITION 4 11/25/13 8:34 P FOUND DEAD

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 966 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 29

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91663-15 F 50 PPM NORMAL 1 11/22/13 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91663-15 F 50 PPM DISPOSITION 4 11/25/13 9:45 P SCHEDULED EUTHANASIA

 91669-01 M 50 PPM NORMAL 1 11/20/13 11:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91669-01 M 50 PPM DISPOSITION 4 11/23/13 12:20 P SCHEDULED EUTHANASIA

 91669-02 M 50 PPM NORMAL 1 11/20/13 11:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91669-02 M 50 PPM DISPOSITION 4 11/23/13 12:20 P SCHEDULED EUTHANASIA

 91669-03 M 50 PPM NORMAL 1 11/20/13 11:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91669-03 M 50 PPM DISPOSITION 4 11/23/13 12:20 P SCHEDULED EUTHANASIA

 91669-04 M 50 PPM NORMAL 1 11/20/13 11:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91669-04 M 50 PPM DISPOSITION 4 11/23/13 12:20 P SCHEDULED EUTHANASIA

 91669-05 M 50 PPM NORMAL 1 11/20/13 11:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91669-05 M 50 PPM DISPOSITION 4 11/23/13 8:58 P FOUND DEAD

 91669-06 M 50 PPM NORMAL 1 11/20/13 11:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91669-06 M 50 PPM DISPOSITION 4 11/23/13 12:21 P SCHEDULED EUTHANASIA

 91669-07 M 50 PPM NORMAL 1 11/20/13 11:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91669-07 M 50 PPM DISPOSITION 4 11/23/13 12:21 P SCHEDULED EUTHANASIA

 91669-08 M 50 PPM NORMAL 1 11/20/13 11:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91669-08 M 50 PPM DISPOSITION 4 11/23/13 12:21 P SCHEDULED EUTHANASIA

 91669-09 M 50 PPM NORMAL 1 11/20/13 11:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91669-09 M 50 PPM DISPOSITION 4 11/23/13 12:21 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 967 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 30

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91669-10 F 50 PPM NORMAL 1 11/20/13 11:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91669-10 F 50 PPM DISPOSITION 4 11/23/13 12:21 P SCHEDULED EUTHANASIA

 91669-11 F 50 PPM NORMAL 1 11/20/13 11:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91669-11 F 50 PPM DISPOSITION 4 11/23/13 8:58 P FOUND DEAD

 91669-12 F 50 PPM NORMAL 1 11/20/13 11:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91669-12 F 50 PPM DISPOSITION 4 11/23/13 12:21 P SCHEDULED EUTHANASIA

 91669-13 F 50 PPM NORMAL 1 11/20/13 11:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91669-13 F 50 PPM DISPOSITION 4 11/23/13 12:21 P SCHEDULED EUTHANASIA

 91669-14 F 50 PPM NORMAL 1 11/20/13 11:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91669-14 F 50 PPM DISPOSITION 4 11/23/13 12:21 P SCHEDULED EUTHANASIA

 91669-15 F 50 PPM NORMAL 1 11/20/13 11:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91669-15 F 50 PPM DISPOSITION 4 11/23/13 8:58 P FOUND DEAD

 91669-16 F 50 PPM NORMAL 1 11/20/13 11:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91669-16 F 50 PPM DISPOSITION 3 11/22/13 13:08 P FOUND DEAD

 91673-01 M 50 PPM NORMAL 1 11/23/13 9:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91673-01 M 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA

 91673-02 M 50 PPM NORMAL 1 11/23/13 9:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91673-02 M 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA

 91673-03 M 50 PPM NORMAL 1 11/23/13 9:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91673-03 M 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA

 91673-04 M 50 PPM NORMAL 1 11/23/13 9:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 968 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 31

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91673-04 M 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA

 91673-05 M 50 PPM NORMAL 1 11/23/13 9:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91673-05 M 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA

 91673-06 M 50 PPM NORMAL 1 11/23/13 9:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91673-06 M 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA

 91673-07 F 50 PPM NORMAL 1 11/23/13 9:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91673-07 F 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA

 91673-08 F 50 PPM NORMAL 1 11/23/13 9:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91673-08 F 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA

 91673-09 F 50 PPM NORMAL 1 11/23/13 9:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91673-09 F 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA

 91673-10 F 50 PPM NORMAL 1 11/23/13 9:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91673-10 F 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA

 91673-11 F 50 PPM NORMAL 1 11/23/13 9:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91673-11 F 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA

 91673-12 F 50 PPM NORMAL 1 11/23/13 9:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91673-12 F 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA

 91673-13 F 50 PPM NORMAL 1 11/23/13 9:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91673-13 F 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA

 91673-14 F 50 PPM NORMAL 1 11/23/13 9:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 969 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 32

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91673-14 F 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA

 91673-15 F 50 PPM NORMAL 1 11/23/13 9:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91673-15 F 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA

 91673-16 F 50 PPM NORMAL 1 11/23/13 9:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91673-16 F 50 PPM DISPOSITION 4 11/26/13 9:53 P SCHEDULED EUTHANASIA

 91683-01 M 50 PPM NORMAL 1 11/24/13 10:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91683-01 M 50 PPM DISPOSITION 4 11/27/13 8:06 P SCHEDULED EUTHANASIA

 91683-02 M 50 PPM NORMAL 1 11/24/13 10:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91683-02 M 50 PPM DISPOSITION 4 11/27/13 8:06 P SCHEDULED EUTHANASIA

 91683-03 M 50 PPM NORMAL 1 11/24/13 10:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91683-03 M 50 PPM DISPOSITION 4 11/27/13 8:06 P SCHEDULED EUTHANASIA

 91683-04 M 50 PPM NORMAL 1 11/24/13 10:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91683-04 M 50 PPM DISPOSITION 4 11/27/13 8:06 P SCHEDULED EUTHANASIA

 91683-05 M 50 PPM NORMAL 1 11/24/13 10:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91683-05 M 50 PPM DISPOSITION 4 11/27/13 8:06 P SCHEDULED EUTHANASIA

 91683-06 M 50 PPM NORMAL 1 11/24/13 10:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91683-06 M 50 PPM DISPOSITION 4 11/27/13 8:06 P SCHEDULED EUTHANASIA

 91683-07 F 50 PPM NORMAL 1 11/24/13 10:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91683-07 F 50 PPM DISPOSITION 4 11/27/13 8:06 P SCHEDULED EUTHANASIA

 91683-08 F 50 PPM NORMAL 1 11/24/13 10:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 970 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 33

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91683-08 F 50 PPM NORMAL 4 11/27/13 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91683-08 F 50 PPM DISPOSITION 4 11/27/13 8:06 P SCHEDULED EUTHANASIA

 91683-09 F 50 PPM NORMAL 1 11/24/13 10:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91683-09 F 50 PPM DISPOSITION 4 11/27/13 8:06 P SCHEDULED EUTHANASIA

 91683-10 F 50 PPM NORMAL 1 11/24/13 10:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91683-10 F 50 PPM DISPOSITION 4 11/27/13 8:06 P SCHEDULED EUTHANASIA

 91683-11 F 50 PPM NORMAL 1 11/24/13 10:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91683-11 F 50 PPM DISPOSITION 4 11/27/13 8:06 P SCHEDULED EUTHANASIA

 91683-12 F 50 PPM NORMAL 1 11/24/13 10:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/27/13 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91683-12 F 50 PPM DISPOSITION 4 11/27/13 8:06 P SCHEDULED EUTHANASIA

 91685-01 M 50 PPM NORMAL 1 11/20/13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91685-01 M 50 PPM DISPOSITION 4 11/23/13 12:23 P SCHEDULED EUTHANASIA

 91685-02 M 50 PPM NORMAL 1 11/20/13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91685-02 M 50 PPM DISPOSITION 4 11/23/13 12:23 P SCHEDULED EUTHANASIA

 91685-03 M 50 PPM NORMAL 1 11/20/13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91685-03 M 50 PPM DISPOSITION 4 11/23/13 12:23 P SCHEDULED EUTHANASIA

 91685-04 M 50 PPM NORMAL 1 11/20/13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91685-04 M 50 PPM DISPOSITION 4 11/23/13 12:23 P SCHEDULED EUTHANASIA

 91685-05 M 50 PPM NORMAL 1 11/20/13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91685-05 M 50 PPM DISPOSITION 4 11/23/13 12:23 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 971 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 34

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91685-06 F 50 PPM NORMAL 1 11/20/13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91685-06 F 50 PPM DISPOSITION 4 11/23/13 12:23 P SCHEDULED EUTHANASIA

 91685-07 F 50 PPM NORMAL 1 11/20/13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91685-07 F 50 PPM DISPOSITION 4 11/23/13 12:23 P SCHEDULED EUTHANASIA

 91685-08 F 50 PPM NORMAL 1 11/20/13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91685-08 F 50 PPM DISPOSITION 2 11/21/13 11:06 P MISSING

 91685-09 F 50 PPM NORMAL 1 11/20/13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91685-09 F 50 PPM DISPOSITION 4 11/23/13 12:24 P SCHEDULED EUTHANASIA

 91685-10 F 50 PPM NORMAL 1 11/20/13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91685-10 F 50 PPM DISPOSITION 4 11/23/13 12:24 P SCHEDULED EUTHANASIA

 91620-01 M 100 PPM DISPOSITION 0 11/22/13 9:29 P FOUND DEAD

 91620-02 M 100 PPM NORMAL 1 11/23/13 9:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91620-02 M 100 PPM DISPOSITION 4 11/26/13 9:54 P SCHEDULED EUTHANASIA

 91620-03 M 100 PPM NORMAL 1 11/23/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91620-03 M 100 PPM DISPOSITION 4 11/26/13 9:54 P SCHEDULED EUTHANASIA

 91620-04 M 100 PPM NORMAL 1 11/23/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91620-04 M 100 PPM DISPOSITION 4 11/26/13 9:54 P SCHEDULED EUTHANASIA

 91620-05 M 100 PPM NORMAL 1 11/23/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91620-05 M 100 PPM DISPOSITION 4 11/26/13 9:54 P SCHEDULED EUTHANASIA

 91620-06 M 100 PPM NORMAL 1 11/23/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 972 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 35

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91620-06 M 100 PPM DISPOSITION 4 11/26/13 9:54 P SCHEDULED EUTHANASIA

 91620-07 M 100 PPM NORMAL 1 11/23/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91620-07 M 100 PPM DISPOSITION 4 11/26/13 9:54 P SCHEDULED EUTHANASIA

 91620-08 M 100 PPM NORMAL 1 11/23/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91620-08 M 100 PPM DISPOSITION 4 11/26/13 9:54 P SCHEDULED EUTHANASIA

 91620-09 M 100 PPM NORMAL 1 11/23/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91620-09 M 100 PPM DISPOSITION 4 11/26/13 9:54 P SCHEDULED EUTHANASIA

 91620-10 F 100 PPM NORMAL 1 11/23/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91620-10 F 100 PPM DISPOSITION 4 11/26/13 9:54 P SCHEDULED EUTHANASIA

 91620-11 F 100 PPM NORMAL 1 11/23/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91620-11 F 100 PPM DISPOSITION 4 11/26/13 9:54 P SCHEDULED EUTHANASIA

 91620-12 F 100 PPM NORMAL 1 11/23/13 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91620-12 F 100 PPM DISPOSITION 4 11/26/13 9:54 P SCHEDULED EUTHANASIA

 91620-13 F 100 PPM NORMAL 1 11/23/13 9:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91620-13 F 100 PPM DISPOSITION 4 11/26/13 9:54 P SCHEDULED EUTHANASIA

 91620-14 F 100 PPM NORMAL 1 11/23/13 9:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91620-14 F 100 PPM DISPOSITION 4 11/26/13 9:55 P SCHEDULED EUTHANASIA

 91628-01 M 100 PPM DISPOSITION 0 11/20/13 14:07 P FOUND DEAD

 91628-02 F 100 PPM NORMAL 4 11/24/13 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91628-02 F 100 PPM DISPOSITION 4 11/24/13 10:18 P SCHEDULED EUTHANASIA

 91628-02 F 100 PPM BODY/INTEGUMENT 0 11/20/13 14:07 P SUBCUTANEOUS HEMORRHAGE FACIAL AREA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 973 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 36

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91628-02 F 100 PPM BODY/INTEGUMENT 1 11/21/13 11:09 P SUBCUTANEOUS HEMORRHAGE FACIAL AREA

 91628-03 M 100 PPM NORMAL 1 11/21/13 11:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91628-03 M 100 PPM DISPOSITION 4 11/24/13 10:18 P SCHEDULED EUTHANASIA

 91628-04 M 100 PPM NORMAL 1 11/21/13 11:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91628-04 M 100 PPM DISPOSITION 4 11/24/13 10:18 P SCHEDULED EUTHANASIA

 91628-05 M 100 PPM NORMAL 1 11/21/13 11:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91628-05 M 100 PPM DISPOSITION 4 11/24/13 10:18 P SCHEDULED EUTHANASIA

 91628-06 M 100 PPM NORMAL 1 11/21/13 11:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91628-06 M 100 PPM DISPOSITION 4 11/24/13 10:18 P SCHEDULED EUTHANASIA

 91628-07 M 100 PPM NORMAL 1 11/21/13 11:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91628-07 M 100 PPM DISPOSITION 4 11/24/13 10:18 P SCHEDULED EUTHANASIA

 91628-08 M 100 PPM NORMAL 1 11/21/13 11:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91628-08 M 100 PPM DISPOSITION 4 11/24/13 10:18 P SCHEDULED EUTHANASIA

 91628-09 M 100 PPM NORMAL 1 11/21/13 11:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91628-09 M 100 PPM DISPOSITION 4 11/24/13 10:18 P SCHEDULED EUTHANASIA

 91628-10 F 100 PPM NORMAL 1 11/21/13 11:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91628-10 F 100 PPM DISPOSITION 4 11/24/13 10:18 P SCHEDULED EUTHANASIA

 91628-11 F 100 PPM NORMAL 1 11/21/13 11:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91628-11 F 100 PPM DISPOSITION 4 11/24/13 10:18 P SCHEDULED EUTHANASIA

 91628-12 F 100 PPM NORMAL 1 11/21/13 11:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 974 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 37

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91628-12 F 100 PPM DISPOSITION 4 11/24/13 10:18 P SCHEDULED EUTHANASIA

 91628-13 F 100 PPM NORMAL 1 11/21/13 11:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91628-13 F 100 PPM DISPOSITION 4 11/24/13 10:18 P SCHEDULED EUTHANASIA

 91628-14 F 100 PPM NORMAL 1 11/21/13 11:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91628-14 F 100 PPM DISPOSITION 4 11/24/13 10:18 P SCHEDULED EUTHANASIA

 91628-15 F 100 PPM NORMAL 1 11/21/13 11:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91628-15 F 100 PPM DISPOSITION 4 11/24/13 10:18 P SCHEDULED EUTHANASIA

 91631-01 M 100 PPM NORMAL 1 11/21/13 11:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91631-01 M 100 PPM DISPOSITION 3 11/23/13 9:15 P FOUND DEAD

 91631-02 M 100 PPM NORMAL 1 11/21/13 11:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91631-02 M 100 PPM DISPOSITION 4 11/24/13 10:19 P SCHEDULED EUTHANASIA

 91631-03 M 100 PPM NORMAL 1 11/21/13 11:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91631-03 M 100 PPM DISPOSITION 4 11/24/13 10:19 P SCHEDULED EUTHANASIA

 91631-04 M 100 PPM NORMAL 1 11/21/13 11:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91631-04 M 100 PPM DISPOSITION 4 11/24/13 10:19 P SCHEDULED EUTHANASIA

 91631-05 M 100 PPM NORMAL 1 11/21/13 11:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91631-05 M 100 PPM DISPOSITION 4 11/24/13 10:19 P SCHEDULED EUTHANASIA

 91631-06 M 100 PPM NORMAL 1 11/21/13 11:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91631-06 M 100 PPM DISPOSITION 4 11/24/13 10:19 P SCHEDULED EUTHANASIA

 91631-07 M 100 PPM NORMAL 1 11/21/13 11:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 975 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 38

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91631-07 M 100 PPM DISPOSITION 4 11/24/13 10:19 P SCHEDULED EUTHANASIA

 91631-08 M 100 PPM DISPOSITION 2 11/22/13 13:10 P FOUND DEAD

 91631-08 M 100 PPM BODY/INTEGUMENT 1 11/21/13 11:14 P SMALL STATURE

 91631-09 M 100 PPM NORMAL 1 11/21/13 11:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91631-09 M 100 PPM DISPOSITION 4 11/24/13 10:19 P SCHEDULED EUTHANASIA

 91631-10 F 100 PPM NORMAL 1 11/21/13 11:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91631-10 F 100 PPM DISPOSITION 4 11/24/13 10:19 P SCHEDULED EUTHANASIA

 91631-11 F 100 PPM NORMAL 1 11/21/13 11:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91631-11 F 100 PPM DISPOSITION 4 11/24/13 10:19 P SCHEDULED EUTHANASIA

 91631-12 F 100 PPM NORMAL 1 11/21/13 11:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91631-12 F 100 PPM DISPOSITION 4 11/24/13 10:19 P SCHEDULED EUTHANASIA

 91631-13 F 100 PPM NORMAL 1 11/21/13 11:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91631-13 F 100 PPM DISPOSITION 4 11/24/13 10:19 P SCHEDULED EUTHANASIA

 91631-14 F 100 PPM NORMAL 1 11/21/13 11:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91631-14 F 100 PPM DISPOSITION 4 11/24/13 10:19 P SCHEDULED EUTHANASIA

 91631-15 F 100 PPM NORMAL 1 11/21/13 11:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91631-15 F 100 PPM DISPOSITION 4 11/24/13 10:19 P SCHEDULED EUTHANASIA

 91636-01 M 100 PPM NORMAL 1 11/22/13 13:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91636-01 M 100 PPM DISPOSITION 4 11/25/13 9:48 P SCHEDULED EUTHANASIA

 91636-02 M 100 PPM NORMAL 1 11/22/13 13:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 976 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 39

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91636-02 M 100 PPM DISPOSITION 4 11/25/13 9:48 P SCHEDULED EUTHANASIA

 91636-03 M 100 PPM NORMAL 1 11/22/13 13:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91636-03 M 100 PPM DISPOSITION 4 11/25/13 9:48 P SCHEDULED EUTHANASIA

 91636-04 M 100 PPM NORMAL 1 11/22/13 13:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91636-04 M 100 PPM DISPOSITION 4 11/25/13 9:48 P SCHEDULED EUTHANASIA

 91636-05 F 100 PPM NORMAL 1 11/22/13 13:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91636-05 F 100 PPM DISPOSITION 4 11/25/13 9:48 P SCHEDULED EUTHANASIA

 91636-06 F 100 PPM NORMAL 1 11/22/13 13:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91636-06 F 100 PPM DISPOSITION 4 11/25/13 9:48 P SCHEDULED EUTHANASIA

 91636-07 F 100 PPM NORMAL 1 11/22/13 13:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91636-07 F 100 PPM DISPOSITION 4 11/25/13 9:48 P SCHEDULED EUTHANASIA

 91636-08 F 100 PPM NORMAL 1 11/22/13 13:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91636-08 F 100 PPM DISPOSITION 4 11/25/13 9:48 P SCHEDULED EUTHANASIA

 91636-09 F 100 PPM NORMAL 1 11/22/13 13:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91636-09 F 100 PPM DISPOSITION 4 11/25/13 9:48 P SCHEDULED EUTHANASIA

 91636-10 F 100 PPM NORMAL 1 11/22/13 13:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91636-10 F 100 PPM DISPOSITION 4 11/25/13 9:48 P SCHEDULED EUTHANASIA

 91636-11 F 100 PPM NORMAL 1 11/22/13 13:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91636-11 F 100 PPM DISPOSITION 4 11/25/13 9:48 P SCHEDULED EUTHANASIA

 91636-12 F 100 PPM NORMAL 1 11/22/13 13:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 977 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 40

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91636-12 F 100 PPM DISPOSITION 4 11/25/13 9:48 P SCHEDULED EUTHANASIA

 91636-13 F 100 PPM NORMAL 1 11/22/13 13:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91636-13 F 100 PPM DISPOSITION 4 11/25/13 9:48 P SCHEDULED EUTHANASIA

 91649-01 M 100 PPM NORMAL 1 11/20/13 11:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91649-01 M 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA

 91649-02 M 100 PPM NORMAL 1 11/20/13 11:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91649-02 M 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA

 91649-03 M 100 PPM NORMAL 1 11/20/13 11:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91649-03 M 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA

 91649-04 M 100 PPM NORMAL 1 11/20/13 11:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91649-04 M 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA

 91649-05 M 100 PPM NORMAL 1 11/20/13 11:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91649-05 M 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA

 91649-06 M 100 PPM NORMAL 1 11/20/13 11:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91649-06 M 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA

 91649-07 F 100 PPM NORMAL 1 11/20/13 11:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91649-07 F 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA

 91649-08 F 100 PPM NORMAL 1 11/20/13 11:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91649-08 F 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA

 91649-09 F 100 PPM NORMAL 1 11/20/13 11:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 978 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 41

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91649-09 F 100 PPM NORMAL 4 11/23/13 9:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91649-09 F 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA

 91649-10 F 100 PPM NORMAL 1 11/20/13 11:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91649-10 F 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA

 91649-11 F 100 PPM NORMAL 1 11/20/13 11:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91649-11 F 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA

 91649-12 F 100 PPM NORMAL 1 11/20/13 11:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91649-12 F 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA

 91649-13 F 100 PPM NORMAL 1 11/20/13 11:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91649-13 F 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA

 91649-14 F 100 PPM NORMAL 1 11/20/13 11:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91649-14 F 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA *

 91649-15 F 100 PPM NORMAL 1 11/20/13 11:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91649-15 F 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA

 91649-16 F 100 PPM NORMAL 1 11/20/13 11:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91649-16 F 100 PPM DISPOSITION 4 11/23/13 12:28 P SCHEDULED EUTHANASIA

 91650-01 M 100 PPM DISPOSITION 0 11/19/13 14:25 P FOUND DEAD

 91650-02 M 100 PPM NORMAL 1 11/20/13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91650-02 M 100 PPM DISPOSITION 4 11/23/13 12:31 P SCHEDULED EUTHANASIA

 91650-03 M 100 PPM NORMAL 1 11/20/13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

 * - LATE COMPUTER ENTRY OBSERVATIONS FOR ABOVE DATES

Page 979 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 42

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91650-03 M 100 PPM DISPOSITION 4 11/23/13 12:31 P SCHEDULED EUTHANASIA

 91650-04 M 100 PPM NORMAL 1 11/20/13 11:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91650-04 M 100 PPM DISPOSITION 4 11/23/13 12:31 P SCHEDULED EUTHANASIA

 91650-05 M 100 PPM NORMAL 4 11/23/13 9:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91650-05 M 100 PPM DISPOSITION 4 11/23/13 12:31 P SCHEDULED EUTHANASIA

 91650-05 M 100 PPM BODY/INTEGUMENT 1 11/20/13 11:57 P BODY PALE

 91650-06 M 100 PPM NORMAL 1 11/20/13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91650-06 M 100 PPM DISPOSITION 4 11/23/13 12:31 P SCHEDULED EUTHANASIA

 91650-07 M 100 PPM NORMAL 1 11/20/13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91650-07 M 100 PPM DISPOSITION 4 11/23/13 12:31 P SCHEDULED EUTHANASIA

 91650-08 M 100 PPM NORMAL 1 11/20/13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91650-08 M 100 PPM DISPOSITION 4 11/23/13 12:31 P SCHEDULED EUTHANASIA

 91650-09 F 100 PPM NORMAL 1 11/20/13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91650-09 F 100 PPM DISPOSITION 4 11/23/13 12:31 P SCHEDULED EUTHANASIA

 91650-10 F 100 PPM NORMAL 1 11/20/13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91650-10 F 100 PPM DISPOSITION 4 11/23/13 12:31 P SCHEDULED EUTHANASIA

 91650-11 F 100 PPM NORMAL 1 11/20/13 11:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91650-11 F 100 PPM DISPOSITION 4 11/23/13 12:31 P SCHEDULED EUTHANASIA

 91650-12 F 100 PPM DISPOSITION 4 11/23/13 12:31 P SCHEDULED EUTHANASIA

 91650-12 F 100 PPM BODY/INTEGUMENT 1 11/20/13 11:59 P SMALL STATURE

 4 11/23/13 9:23 P SMALL STATURE

 91650-13 F 100 PPM NORMAL 1 11/20/13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 980 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 43

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91650-13 F 100 PPM DISPOSITION 4 11/23/13 12:32 P SCHEDULED EUTHANASIA

 91650-14 F 100 PPM NORMAL 1 11/20/13 11:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91650-14 F 100 PPM DISPOSITION 4 11/23/13 12:32 P SCHEDULED EUTHANASIA

 91656-01 F 100 PPM DISPOSITION 0 11/24/13 13:38 P FOUND DEAD

 91656-02 M 100 PPM DISPOSITION 1 11/25/13 9:58 P MISSING

 91656-02 M 100 PPM BODY/INTEGUMENT 0 11/24/13 13:38 P CYANOTIC

 91656-03 M 100 PPM NORMAL 1 11/25/13 9:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/28/13 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91656-03 M 100 PPM DISPOSITION 4 11/28/13 7:57 P SCHEDULED EUTHANASIA

 91656-04 M 100 PPM NORMAL 1 11/25/13 9:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/28/13 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91656-04 M 100 PPM DISPOSITION 4 11/28/13 7:57 P SCHEDULED EUTHANASIA

 91656-05 M 100 PPM DISPOSITION 1 11/25/13 10:00 P MISSING

 91656-06 M 100 PPM NORMAL 1 11/25/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/28/13 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91656-06 M 100 PPM DISPOSITION 4 11/28/13 7:57 P SCHEDULED EUTHANASIA

 91656-07 M 100 PPM NORMAL 1 11/25/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/28/13 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91656-07 M 100 PPM DISPOSITION 4 11/28/13 7:57 P SCHEDULED EUTHANASIA

 91656-08 F 100 PPM NORMAL 1 11/25/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/28/13 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91656-08 F 100 PPM DISPOSITION 4 11/28/13 7:57 P SCHEDULED EUTHANASIA

 91656-09 F 100 PPM NORMAL 1 11/25/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/28/13 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91656-09 F 100 PPM DISPOSITION 4 11/28/13 7:57 P SCHEDULED EUTHANASIA

 91656-10 F 100 PPM NORMAL 1 11/25/13 10:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/28/13 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91656-10 F 100 PPM DISPOSITION 4 11/28/13 7:57 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 981 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 44

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91656-11 F 100 PPM NORMAL 1 11/25/13 10:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/28/13 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91656-11 F 100 PPM DISPOSITION 4 11/28/13 7:57 P SCHEDULED EUTHANASIA

 91656-12 F 100 PPM NORMAL 1 11/25/13 10:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS *

 4 11/28/13 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91656-12 F 100 PPM DISPOSITION 4 11/28/13 7:57 P SCHEDULED EUTHANASIA

 91656-13 F 100 PPM NORMAL 1 11/25/13 10:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/28/13 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91656-13 F 100 PPM DISPOSITION 4 11/28/13 7:57 P SCHEDULED EUTHANASIA

 91656-14 F 100 PPM NORMAL 1 11/25/13 10:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91656-14 F 100 PPM DISPOSITION 3 11/27/13 8:09 P MISSING

 91656-15 F 100 PPM NORMAL 1 11/25/13 10:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS *

 4 11/28/13 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91656-15 F 100 PPM DISPOSITION 4 11/28/13 7:57 P SCHEDULED EUTHANASIA

 91671-01 M 100 PPM DISPOSITION 0 11/24/13 8:00 P FOUND DEAD

 91671-02 F 100 PPM DISPOSITION 0 11/24/13 8:00 P FOUND DEAD

 91671-03 M 100 PPM NORMAL 1 11/25/13 10:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/28/13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91671-03 M 100 PPM DISPOSITION 4 11/28/13 7:58 P SCHEDULED EUTHANASIA

 91671-04 M 100 PPM NORMAL 1 11/25/13 10:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/28/13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91671-04 M 100 PPM DISPOSITION 4 11/28/13 7:58 P SCHEDULED EUTHANASIA

 91671-05 M 100 PPM NORMAL 1 11/25/13 10:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/28/13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91671-05 M 100 PPM DISPOSITION 4 11/28/13 7:58 P SCHEDULED EUTHANASIA

 91671-06 M 100 PPM NORMAL 1 11/25/13 10:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS *

 4 11/28/13 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91671-06 M 100 PPM DISPOSITION 4 11/28/13 7:58 P SCHEDULED EUTHANASIA

 91671-07 M 100 PPM DISPOSITION 1 11/25/13 10:07 P MISSING *

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

 * - LATE COMPUTER ENTRY OBSERVATIONS FOR ABOVE DATES

Page 982 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 45

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91671-08 M 100 PPM NORMAL 1 11/25/13 10:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/28/13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91671-08 M 100 PPM DISPOSITION 4 11/28/13 7:58 P SCHEDULED EUTHANASIA

 91671-09 M 100 PPM NORMAL 1 11/25/13 10:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/28/13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91671-09 M 100 PPM DISPOSITION 4 11/28/13 7:59 P SCHEDULED EUTHANASIA

 91671-10 F 100 PPM NORMAL 1 11/25/13 10:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/28/13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91671-10 F 100 PPM DISPOSITION 4 11/28/13 7:59 P SCHEDULED EUTHANASIA

 91671-11 F 100 PPM DISPOSITION 1 11/25/13 10:07 P FOUND DEAD

 91671-12 F 100 PPM NORMAL 1 11/25/13 10:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/28/13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91671-12 F 100 PPM DISPOSITION 4 11/28/13 7:59 P SCHEDULED EUTHANASIA

 91671-13 F 100 PPM NORMAL 1 11/25/13 10:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/28/13 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91671-13 F 100 PPM DISPOSITION 4 11/28/13 7:59 P SCHEDULED EUTHANASIA

 91671-14 F 100 PPM NORMAL 1 11/25/13 10:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/28/13 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91671-14 F 100 PPM DISPOSITION 4 11/28/13 7:59 P SCHEDULED EUTHANASIA

 91671-15 F 100 PPM NORMAL 1 11/25/13 10:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/28/13 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91671-15 F 100 PPM DISPOSITION 4 11/28/13 7:59 P SCHEDULED EUTHANASIA

 91675-01 M 100 PPM NORMAL 1 11/21/13 11:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91675-01 M 100 PPM DISPOSITION 4 11/24/13 10:20 P SCHEDULED EUTHANASIA

 91675-02 M 100 PPM NORMAL 1 11/21/13 11:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91675-02 M 100 PPM DISPOSITION 4 11/24/13 10:20 P SCHEDULED EUTHANASIA

 91675-03 M 100 PPM NORMAL 1 11/21/13 11:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 983 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 46

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91675-03 M 100 PPM NORMAL 4 11/24/13 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91675-03 M 100 PPM DISPOSITION 4 11/24/13 10:20 P SCHEDULED EUTHANASIA

 91675-04 M 100 PPM DISPOSITION 1 11/21/13 11:20 P FOUND DEAD

 91675-05 M 100 PPM NORMAL 1 11/21/13 11:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91675-05 M 100 PPM DISPOSITION 4 11/24/13 10:20 P SCHEDULED EUTHANASIA

 91675-06 F 100 PPM NORMAL 1 11/21/13 11:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91675-06 F 100 PPM DISPOSITION 4 11/24/13 10:20 P SCHEDULED EUTHANASIA

 91675-07 F 100 PPM NORMAL 1 11/21/13 11:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91675-07 F 100 PPM DISPOSITION 4 11/24/13 10:20 P SCHEDULED EUTHANASIA

 91675-08 F 100 PPM NORMAL 1 11/21/13 11:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91675-08 F 100 PPM DISPOSITION 4 11/24/13 10:21 P SCHEDULED EUTHANASIA

 91675-09 F 100 PPM NORMAL 1 11/21/13 11:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91675-09 F 100 PPM DISPOSITION 4 11/24/13 10:21 P SCHEDULED EUTHANASIA

 91675-10 F 100 PPM NORMAL 1 11/21/13 11:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91675-10 F 100 PPM DISPOSITION 4 11/24/13 10:21 P SCHEDULED EUTHANASIA

 91675-11 F 100 PPM NORMAL 1 11/21/13 11:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91675-11 F 100 PPM DISPOSITION 4 11/24/13 8:31 P FOUND DEAD

 91675-12 F 100 PPM NORMAL 1 11/21/13 11:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91675-12 F 100 PPM DISPOSITION 4 11/24/13 10:21 P SCHEDULED EUTHANASIA

 91675-13 F 100 PPM NORMAL 1 11/21/13 11:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91675-13 F 100 PPM DISPOSITION 4 11/24/13 10:21 P SCHEDULED EUTHANASIA

 91675-14 F 100 PPM NORMAL 1 11/21/13 11:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 984 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 47

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91675-14 F 100 PPM DISPOSITION 2 11/22/13 13:17 P MISSING

 91677-01 M 100 PPM NORMAL 1 11/22/13 13:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91677-01 M 100 PPM DISPOSITION 3 11/24/13 10:22 P FOUND DEAD

 91677-02 M 100 PPM NORMAL 1 11/22/13 13:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91677-02 M 100 PPM DISPOSITION 4 11/25/13 10:13 P SCHEDULED EUTHANASIA

 91677-03 F 100 PPM NORMAL 1 11/22/13 13:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91677-03 F 100 PPM DISPOSITION 4 11/25/13 10:13 P SCHEDULED EUTHANASIA

 91677-04 F 100 PPM NORMAL 1 11/22/13 13:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91677-04 F 100 PPM DISPOSITION 3 11/24/13 10:22 P MISSING

 91677-05 F 100 PPM NORMAL 1 11/22/13 13:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91677-05 F 100 PPM DISPOSITION 4 11/25/13 10:13 P SCHEDULED EUTHANASIA

 91679-01 M 100 PPM DISPOSITION 0 11/19/13 14:28 P FOUND DEAD

 91679-02 F 100 PPM DISPOSITION 0 11/19/13 14:28 P FOUND DEAD

 91679-03 M 100 PPM NORMAL 1 11/20/13 12:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91679-03 M 100 PPM DISPOSITION 4 11/23/13 12:34 P SCHEDULED EUTHANASIA

 91679-04 M 100 PPM NORMAL 1 11/20/13 12:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91679-04 M 100 PPM DISPOSITION 4 11/23/13 12:34 P SCHEDULED EUTHANASIA

 91679-05 M 100 PPM NORMAL 1 11/20/13 12:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91679-05 M 100 PPM DISPOSITION 4 11/23/13 12:34 P SCHEDULED EUTHANASIA

 91679-06 M 100 PPM NORMAL 1 11/20/13 12:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91679-06 M 100 PPM DISPOSITION 2 11/21/13 11:28 P MISSING

 91679-07 M 100 PPM NORMAL 1 11/20/13 12:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 985 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 48

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91679-07 M 100 PPM NORMAL 4 11/23/13 9:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91679-07 M 100 PPM DISPOSITION 4 11/23/13 12:34 P SCHEDULED EUTHANASIA

 91679-08 M 100 PPM NORMAL 1 11/20/13 12:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91679-08 M 100 PPM DISPOSITION 4 11/23/13 12:34 P SCHEDULED EUTHANASIA

 91679-09 F 100 PPM NORMAL 1 11/20/13 12:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91679-09 F 100 PPM DISPOSITION 4 11/23/13 12:34 P SCHEDULED EUTHANASIA

 91679-10 F 100 PPM NORMAL 1 11/20/13 12:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91679-10 F 100 PPM DISPOSITION 2 11/21/13 11:28 P FOUND DEAD

 91679-11 F 100 PPM DISPOSITION 1 11/20/13 12:06 P FOUND DEAD

 91679-12 F 100 PPM NORMAL 1 11/20/13 12:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91679-12 F 100 PPM DISPOSITION 4 11/23/13 12:34 P SCHEDULED EUTHANASIA

 91684-01 M 100 PPM NORMAL 1 11/21/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91684-01 M 100 PPM DISPOSITION 4 11/24/13 10:24 P SCHEDULED EUTHANASIA

 91684-02 M 100 PPM NORMAL 1 11/21/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91684-02 M 100 PPM DISPOSITION 4 11/24/13 10:24 P SCHEDULED EUTHANASIA

 91684-03 M 100 PPM NORMAL 1 11/21/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91684-03 M 100 PPM DISPOSITION 4 11/24/13 10:24 P SCHEDULED EUTHANASIA

 91684-04 M 100 PPM NORMAL 1 11/21/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91684-04 M 100 PPM DISPOSITION 4 11/24/13 10:24 P SCHEDULED EUTHANASIA

 91684-05 M 100 PPM NORMAL 1 11/21/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91684-05 M 100 PPM DISPOSITION 4 11/24/13 10:24 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 986 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 49

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91684-06 M 100 PPM NORMAL 1 11/21/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91684-06 M 100 PPM DISPOSITION 4 11/24/13 10:24 P SCHEDULED EUTHANASIA

 91684-07 M 100 PPM NORMAL 1 11/21/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91684-07 M 100 PPM DISPOSITION 4 11/24/13 10:24 P SCHEDULED EUTHANASIA

 91684-08 M 100 PPM NORMAL 1 11/21/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91684-08 M 100 PPM DISPOSITION 4 11/24/13 10:24 P SCHEDULED EUTHANASIA

 91684-09 M 100 PPM NORMAL 1 11/21/13 11:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91684-09 M 100 PPM DISPOSITION 4 11/24/13 10:24 P SCHEDULED EUTHANASIA

 91684-10 F 100 PPM NORMAL 1 11/21/13 11:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91684-10 F 100 PPM DISPOSITION 4 11/24/13 10:24 P SCHEDULED EUTHANASIA

 91684-11 F 100 PPM NORMAL 1 11/21/13 11:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91684-11 F 100 PPM DISPOSITION 4 11/24/13 10:24 P SCHEDULED EUTHANASIA

 91684-12 F 100 PPM NORMAL 1 11/21/13 11:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91684-12 F 100 PPM DISPOSITION 4 11/24/13 10:24 P SCHEDULED EUTHANASIA

 91684-13 F 100 PPM NORMAL 1 11/21/13 11:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91684-13 F 100 PPM DISPOSITION 4 11/24/13 10:24 P SCHEDULED EUTHANASIA

 91684-14 F 100 PPM NORMAL 1 11/21/13 11:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91684-14 F 100 PPM DISPOSITION 4 11/24/13 10:24 P SCHEDULED EUTHANASIA

 91684-15 F 100 PPM NORMAL 1 11/21/13 11:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91684-15 F 100 PPM DISPOSITION 4 11/24/13 10:25 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 987 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 50

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91684-16 F 100 PPM NORMAL 1 11/21/13 11:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91684-16 F 100 PPM DISPOSITION 4 11/24/13 10:25 P SCHEDULED EUTHANASIA

 91622-01 M 175 PPM DISPOSITION 1 11/20/13 7:12 P FOUND DEAD

 91622-02 M 175 PPM DISPOSITION 1 11/20/13 7:12 P FOUND DEAD

 91622-03 F 175 PPM DISPOSITION 1 11/20/13 7:12 P FOUND DEAD

 91622-04 M 175 PPM NORMAL 1 11/20/13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91622-04 M 175 PPM DISPOSITION 4 11/23/13 12:37 P SCHEDULED EUTHANASIA

 91622-05 M 175 PPM NORMAL 1 11/20/13 12:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91622-05 M 175 PPM DISPOSITION 4 11/23/13 12:37 P SCHEDULED EUTHANASIA

 91622-06 M 175 PPM NORMAL 4 11/23/13 9:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91622-06 M 175 PPM DISPOSITION 4 11/23/13 12:37 P SCHEDULED EUTHANASIA

 91622-06 M 175 PPM BODY/INTEGUMENT 1 11/20/13 12:15 P SUBCUTANEOUS HEMORRHAGE FACIAL AREA

 91622-07 M 175 PPM NORMAL 1 11/20/13 12:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91622-07 M 175 PPM DISPOSITION 4 11/23/13 12:37 P SCHEDULED EUTHANASIA

 91622-08 M 175 PPM NORMAL 1 11/20/13 12:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91622-08 M 175 PPM DISPOSITION 2 11/21/13 11:36 P FOUND DEAD

 91622-09 M 175 PPM NORMAL 1 11/20/13 12:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91622-09 M 175 PPM DISPOSITION 4 11/23/13 12:38 P SCHEDULED EUTHANASIA

 91622-10 M 175 PPM NORMAL 1 11/20/13 12:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91622-10 M 175 PPM DISPOSITION 4 11/23/13 12:38 P SCHEDULED EUTHANASIA

 91622-10 M 175 PPM BODY/INTEGUMENT 4 11/23/13 9:31 P SUBCUTANEOUS HEMORRHAGE DORSAL HEAD

 91622-11 F 175 PPM NORMAL 1 11/20/13 12:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91622-11 F 175 PPM DISPOSITION 4 11/23/13 12:38 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 988 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 51

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91622-12 F 175 PPM NORMAL 1 11/20/13 12:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91622-12 F 175 PPM DISPOSITION 4 11/23/13 12:38 P SCHEDULED EUTHANASIA

 91622-13 F 175 PPM NORMAL 1 11/20/13 12:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91622-13 F 175 PPM DISPOSITION 2 11/21/13 11:36 P FOUND DEAD

 91622-14 F 175 PPM NORMAL 1 11/20/13 12:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91622-14 F 175 PPM DISPOSITION 3 11/22/13 13:22 P FOUND DEAD

 91626-01 F 175 PPM DISPOSITION 1 11/23/13 9:33 P FOUND DEAD

 91626-01 F 175 PPM BODY/INTEGUMENT 0 11/22/13 14:08 P SMALL STATURE

 91626-02 M 175 PPM NORMAL 1 11/23/13 9:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91626-02 M 175 PPM DISPOSITION 4 11/26/13 9:56 P SCHEDULED EUTHANASIA

 91626-03 M 175 PPM NORMAL 1 11/23/13 9:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91626-03 M 175 PPM DISPOSITION 4 11/26/13 9:56 P SCHEDULED EUTHANASIA

 91626-04 M 175 PPM NORMAL 1 11/23/13 9:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91626-04 M 175 PPM DISPOSITION 4 11/26/13 9:56 P SCHEDULED EUTHANASIA

 91626-05 M 175 PPM NORMAL 1 11/23/13 9:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91626-05 M 175 PPM DISPOSITION 4 11/26/13 9:56 P SCHEDULED EUTHANASIA

 91626-06 M 175 PPM NORMAL 1 11/23/13 9:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91626-06 M 175 PPM DISPOSITION 4 11/26/13 9:56 P SCHEDULED EUTHANASIA

 91626-07 M 175 PPM NORMAL 1 11/23/13 9:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91626-07 M 175 PPM DISPOSITION 4 11/26/13 9:56 P SCHEDULED EUTHANASIA

 91626-08 F 175 PPM NORMAL 1 11/23/13 9:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 989 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 52

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91626-08 F 175 PPM DISPOSITION 4 11/26/13 9:56 P SCHEDULED EUTHANASIA

 91626-09 F 175 PPM NORMAL 1 11/23/13 9:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91626-09 F 175 PPM DISPOSITION 4 11/26/13 9:56 P SCHEDULED EUTHANASIA

 91626-10 F 175 PPM NORMAL 1 11/23/13 9:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91626-10 F 175 PPM DISPOSITION 4 11/26/13 9:56 P SCHEDULED EUTHANASIA

 91626-11 F 175 PPM NORMAL 1 11/23/13 9:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91626-11 F 175 PPM DISPOSITION 4 11/26/13 9:56 P SCHEDULED EUTHANASIA

 91626-12 F 175 PPM NORMAL 1 11/23/13 9:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91626-12 F 175 PPM DISPOSITION 4 11/26/13 9:56 P SCHEDULED EUTHANASIA

 91626-13 F 175 PPM NORMAL 1 11/23/13 9:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91626-13 F 175 PPM DISPOSITION 4 11/26/13 9:56 P SCHEDULED EUTHANASIA

 91626-14 F 175 PPM NORMAL 1 11/23/13 9:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91626-14 F 175 PPM DISPOSITION 4 11/26/13 9:56 P SCHEDULED EUTHANASIA

 91643-01 M 175 PPM DISPOSITION 1 11/26/13 9:59 P FOUND DEAD

 91643-01 M 175 PPM BODY/INTEGUMENT 1 11/26/13 7:57 P SUBCUTANEOUS HEMORRHAGE FACIAL AREA

 91643-02 M 175 PPM NORMAL 1 11/26/13 9:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/29/13 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91643-02 M 175 PPM DISPOSITION 4 11/29/13 7:52 P SCHEDULED EUTHANASIA

 91643-03 M 175 PPM NORMAL 1 11/26/13 9:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/29/13 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91643-03 M 175 PPM DISPOSITION 4 11/29/13 7:52 P SCHEDULED EUTHANASIA

 91643-04 M 175 PPM NORMAL 1 11/26/13 9:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/29/13 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 990 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 53

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91643-04 M 175 PPM DISPOSITION 4 11/29/13 7:52 P SCHEDULED EUTHANASIA

 91643-05 M 175 PPM NORMAL 1 11/26/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/29/13 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91643-05 M 175 PPM DISPOSITION 4 11/29/13 7:52 P SCHEDULED EUTHANASIA

 91643-06 M 175 PPM NORMAL 1 11/26/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/29/13 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91643-06 M 175 PPM DISPOSITION 4 11/29/13 7:52 P SCHEDULED EUTHANASIA

 91643-07 M 175 PPM NORMAL 1 11/26/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/29/13 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91643-07 M 175 PPM DISPOSITION 4 11/29/13 7:52 P SCHEDULED EUTHANASIA

 91643-08 M 175 PPM NORMAL 1 11/26/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/29/13 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91643-08 M 175 PPM DISPOSITION 4 11/29/13 7:53 P SCHEDULED EUTHANASIA

 91643-09 M 175 PPM NORMAL 1 11/26/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/29/13 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91643-09 M 175 PPM DISPOSITION 4 11/29/13 7:53 P SCHEDULED EUTHANASIA

 91643-10 F 175 PPM NORMAL 1 11/26/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/29/13 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91643-10 F 175 PPM DISPOSITION 4 11/29/13 7:53 P SCHEDULED EUTHANASIA

 91643-11 F 175 PPM NORMAL 1 11/26/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/29/13 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91643-11 F 175 PPM DISPOSITION 4 11/29/13 7:53 P SCHEDULED EUTHANASIA

 91643-12 F 175 PPM NORMAL 1 11/26/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/29/13 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91643-12 F 175 PPM DISPOSITION 4 11/29/13 7:53 P SCHEDULED EUTHANASIA

 91654-01 F 175 PPM DISPOSITION 0 11/25/13 13:44 P FOUND DEAD

 91654-02 M 175 PPM DISPOSITION 0 11/25/13 13:44 P FOUND DEAD

 91654-03 M 175 PPM DISPOSITION 1 11/26/13 10:04 P FOUND DEAD

 91654-04 M 175 PPM NORMAL 1 11/26/13 10:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 991 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 54

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91654-04 M 175 PPM DISPOSITION 2 11/27/13 8:13 P FOUND DEAD

 91654-05 M 175 PPM NORMAL 1 11/26/13 10:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91654-05 M 175 PPM DISPOSITION 2 11/27/13 8:13 P FOUND DEAD

 91654-06 M 175 PPM NORMAL 1 11/26/13 10:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91654-06 M 175 PPM DISPOSITION 2 11/27/13 8:14 P MISSING

 91654-07 M 175 PPM NORMAL 1 11/26/13 10:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91654-07 M 175 PPM DISPOSITION 2 11/27/13 8:13 P FOUND DEAD

 91654-08 M 175 PPM NORMAL 1 11/26/13 10:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91654-08 M 175 PPM DISPOSITION 2 11/27/13 8:13 P FOUND DEAD

 91654-09 M 175 PPM DISPOSITION 2 11/27/13 8:13 P FOUND DEAD

 91654-09 M 175 PPM BODY/INTEGUMENT 1 11/26/13 10:05 P SUBCUTANEOUS HEMORRHAGE FACIAL AREA

 91654-10 M 175 PPM DISPOSITION 1 11/26/13 10:04 P FOUND DEAD

 91654-11 M 175 PPM NORMAL 1 11/26/13 10:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91654-11 M 175 PPM DISPOSITION 2 11/27/13 8:14 P MISSING

 91654-12 M 175 PPM DISPOSITION 2 11/27/13 8:13 P FOUND DEAD

 91654-12 M 175 PPM BODY/INTEGUMENT 1 11/26/13 10:05 P SUBCUTANEOUS HEMORRHAGE FACIAL AREA

 91654-13 M 175 PPM NORMAL 1 11/26/13 10:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91654-13 M 175 PPM DISPOSITION 2 11/27/13 8:14 P MISSING

 91654-14 F 175 PPM DISPOSITION 2 11/27/13 8:13 P FOUND DEAD

 91654-14 F 175 PPM BODY/INTEGUMENT 1 11/26/13 10:07 P CYANOTIC

 91654-15 F 175 PPM DISPOSITION 2 11/27/13 8:14 P MISSING

 91654-15 F 175 PPM BODY/INTEGUMENT 1 11/26/13 10:07 P CYANOTIC

 91654-16 F 175 PPM NORMAL 1 11/26/13 10:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91654-16 F 175 PPM DISPOSITION 2 11/27/13 8:14 P MISSING

 91654-17 F 175 PPM NORMAL 1 11/26/13 10:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91654-17 F 175 PPM DISPOSITION 2 11/27/13 8:14 P FOUND DEAD

 91654-18 F 175 PPM NORMAL 1 11/26/13 10:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91654-18 F 175 PPM DISPOSITION 2 11/27/13 8:14 P MISSING

 91657-01 F 175 PPM DISPOSITION 2 12/02/13 7:24 P FOUND DEAD

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 992 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 55

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91657-01 F 175 PPM BODY/INTEGUMENT 1 12/01/13 6:32 P TAIL MISSING

 1 12/01/13 6:34 P TAIL MISSING

 91657-02 M 175 PPM NORMAL 1 12/01/13 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91657-02 M 175 PPM DISPOSITION 2 12/02/13 7:23 P FOUND DEAD

 91657-03 M 175 PPM NORMAL 1 12/01/13 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91657-03 M 175 PPM DISPOSITION 2 12/02/13 7:24 P FOUND DEAD

 91657-04 M 175 PPM NORMAL 1 12/01/13 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 12/04/13 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91657-04 M 175 PPM DISPOSITION 4 12/04/13 10:27 P SCHEDULED EUTHANASIA

 91657-05 M 175 PPM NORMAL 1 12/01/13 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 12/04/13 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91657-05 M 175 PPM DISPOSITION 4 12/04/13 10:27 P SCHEDULED EUTHANASIA

 91657-06 M 175 PPM NORMAL 1 12/01/13 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 12/04/13 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91657-06 M 175 PPM DISPOSITION 4 12/04/13 10:27 P SCHEDULED EUTHANASIA

 91657-07 M 175 PPM NORMAL 1 12/01/13 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91657-07 M 175 PPM DISPOSITION 2 12/02/13 7:23 P FOUND DEAD

 91657-08 F 175 PPM NORMAL 1 12/01/13 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91657-08 F 175 PPM DISPOSITION 2 12/02/13 7:24 P FOUND DEAD

 91657-09 F 175 PPM NORMAL 1 12/01/13 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 12/04/13 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91657-09 F 175 PPM DISPOSITION 4 12/04/13 10:27 P SCHEDULED EUTHANASIA

 91657-10 F 175 PPM NORMAL 1 12/01/13 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 12/04/13 7:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91657-10 F 175 PPM DISPOSITION 4 12/04/13 10:27 P SCHEDULED EUTHANASIA

 91657-11 F 175 PPM NORMAL 1 12/01/13 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 12/04/13 7:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91657-11 F 175 PPM DISPOSITION 4 12/04/13 10:27 P SCHEDULED EUTHANASIA

 91657-12 F 175 PPM NORMAL 1 12/01/13 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 12/04/13 7:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 993 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 56

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91657-12 F 175 PPM DISPOSITION 4 12/04/13 10:27 P SCHEDULED EUTHANASIA

 91657-13 F 175 PPM NORMAL 1 12/01/13 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 12/04/13 7:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91657-13 F 175 PPM DISPOSITION 4 12/04/13 10:27 P SCHEDULED EUTHANASIA

 91662-01 M 175 PPM DISPOSITION 0 11/22/13 9:35 P FOUND DEAD

 91662-02 F 175 PPM DISPOSITION 0 11/22/13 9:36 P FOUND DEAD-A

 91662-03 M 175 PPM NORMAL 1 11/23/13 9:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91662-03 M 175 PPM DISPOSITION 4 11/26/13 10:10 P SCHEDULED EUTHANASIA

 91662-04 M 175 PPM NORMAL 1 11/23/13 9:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91662-04 M 175 PPM DISPOSITION 4 11/26/13 10:10 P SCHEDULED EUTHANASIA

 91662-05 M 175 PPM NORMAL 1 11/23/13 9:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91662-05 M 175 PPM DISPOSITION 4 11/26/13 10:10 P SCHEDULED EUTHANASIA

 91662-06 M 175 PPM NORMAL 1 11/23/13 9:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91662-06 M 175 PPM DISPOSITION 4 11/26/13 10:10 P SCHEDULED EUTHANASIA

 91662-07 F 175 PPM NORMAL 1 11/23/13 9:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91662-07 F 175 PPM DISPOSITION 2 11/24/13 10:27 P MISSING

 91662-08 F 175 PPM NORMAL 1 11/23/13 9:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91662-08 F 175 PPM DISPOSITION 3 11/25/13 10:18 P MISSING

 91662-09 F 175 PPM NORMAL 1 11/23/13 9:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91662-09 F 175 PPM DISPOSITION 4 11/26/13 10:11 P SCHEDULED EUTHANASIA

 91662-10 F 175 PPM NORMAL 1 11/23/13 9:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91662-10 F 175 PPM DISPOSITION 4 11/26/13 10:11 P SCHEDULED EUTHANASIA

 91662-11 F 175 PPM NORMAL 1 11/23/13 9:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

A = PUP FOUND DEAD ON PND 0, BUT HAD MILK IN STOMACH; PUP CONSIDERED BORN ALIVE.

Page 994 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 57

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91662-11 F 175 PPM NORMAL 4 11/26/13 9:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91662-11 F 175 PPM DISPOSITION 4 11/26/13 10:11 P SCHEDULED EUTHANASIA

 91666-01 F 175 PPM DISPOSITION 1 11/21/13 11:42 P FOUND DEAD

 91666-01 F 175 PPM BODY/INTEGUMENT 0 11/20/13 8:42 P CYANOTIC

 0 11/20/13 8:43 P SUBCUTANEOUS HEMORRHAGE DORSAL HEAD

 91666-01 F 175 PPM CARDIO-PULMONARY 0 11/20/13 8:43 P GASPING

 91666-02 M 175 PPM NORMAL 1 11/21/13 11:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 9:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91666-02 M 175 PPM DISPOSITION 4 11/24/13 10:28 P SCHEDULED EUTHANASIA

 91666-03 M 175 PPM NORMAL 1 11/21/13 11:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 9:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91666-03 M 175 PPM DISPOSITION 4 11/24/13 10:28 P SCHEDULED EUTHANASIA

 91666-04 M 175 PPM NORMAL 1 11/21/13 11:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 9:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91666-04 M 175 PPM DISPOSITION 4 11/24/13 10:28 P SCHEDULED EUTHANASIA

 91666-05 M 175 PPM NORMAL 1 11/21/13 11:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 9:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91666-05 M 175 PPM DISPOSITION 4 11/24/13 10:28 P SCHEDULED EUTHANASIA

 91666-06 M 175 PPM NORMAL 1 11/21/13 11:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 9:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91666-06 M 175 PPM DISPOSITION 4 11/24/13 10:28 P SCHEDULED EUTHANASIA

 91666-07 M 175 PPM NORMAL 1 11/21/13 11:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 9:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91666-07 M 175 PPM DISPOSITION 4 11/24/13 10:28 P SCHEDULED EUTHANASIA

 91666-08 M 175 PPM NORMAL 1 11/21/13 11:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 9:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91666-08 M 175 PPM DISPOSITION 4 11/24/13 10:28 P SCHEDULED EUTHANASIA

 91666-09 F 175 PPM NORMAL 1 11/21/13 11:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 9:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 995 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 58

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91666-09 F 175 PPM DISPOSITION 4 11/24/13 10:28 P SCHEDULED EUTHANASIA

 91666-10 F 175 PPM NORMAL 1 11/21/13 11:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 9:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91666-10 F 175 PPM DISPOSITION 4 11/24/13 10:28 P SCHEDULED EUTHANASIA

 91666-11 F 175 PPM NORMAL 1 11/21/13 11:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 9:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91666-11 F 175 PPM DISPOSITION 4 11/24/13 10:28 P SCHEDULED EUTHANASIA

 91676-01 M 175 PPM NORMAL 1 11/22/13 13:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91676-01 M 175 PPM DISPOSITION 4 11/25/13 10:18 P SCHEDULED EUTHANASIA

 91676-02 M 175 PPM NORMAL 1 11/22/13 13:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91676-02 M 175 PPM DISPOSITION 4 11/25/13 10:18 P SCHEDULED EUTHANASIA

 91676-03 M 175 PPM NORMAL 1 11/22/13 13:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91676-03 M 175 PPM DISPOSITION 4 11/25/13 10:18 P SCHEDULED EUTHANASIA

 91676-04 M 175 PPM NORMAL 1 11/22/13 13:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91676-04 M 175 PPM DISPOSITION 4 11/25/13 10:18 P SCHEDULED EUTHANASIA

 91676-05 M 175 PPM NORMAL 1 11/22/13 13:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91676-05 M 175 PPM DISPOSITION 4 11/25/13 10:18 P SCHEDULED EUTHANASIA

 91676-06 F 175 PPM NORMAL 1 11/22/13 13:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91676-06 F 175 PPM DISPOSITION 4 11/25/13 10:18 P SCHEDULED EUTHANASIA

 91676-07 F 175 PPM NORMAL 1 11/22/13 13:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91676-07 F 175 PPM DISPOSITION 4 11/25/13 10:18 P SCHEDULED EUTHANASIA

 91676-08 F 175 PPM NORMAL 1 11/22/13 13:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 996 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 59

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91676-08 F 175 PPM NORMAL 4 11/25/13 8:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91676-08 F 175 PPM DISPOSITION 4 11/25/13 10:19 P SCHEDULED EUTHANASIA

 91676-09 F 175 PPM NORMAL 1 11/22/13 13:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91676-09 F 175 PPM DISPOSITION 4 11/25/13 10:19 P SCHEDULED EUTHANASIA

 91676-10 F 175 PPM DISPOSITION 1 11/22/13 13:25 P MISSING

 91676-11 F 175 PPM NORMAL 1 11/22/13 13:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91676-11 F 175 PPM DISPOSITION 4 11/25/13 10:19 P SCHEDULED EUTHANASIA

 91678-01 M 175 PPM NORMAL 1 11/21/13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91678-01 M 175 PPM DISPOSITION 4 11/24/13 10:29 P SCHEDULED EUTHANASIA

 91678-01 M 175 PPM BODY/INTEGUMENT 0 11/20/13 8:52 P SUBCUTANEOUS HEMORRHAGE FACIAL AREA

 91678-02 M 175 PPM NORMAL 1 11/21/13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91678-02 M 175 PPM DISPOSITION 4 11/24/13 10:29 P SCHEDULED EUTHANASIA

 91678-03 M 175 PPM NORMAL 1 11/21/13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91678-03 M 175 PPM DISPOSITION 4 11/24/13 10:29 P SCHEDULED EUTHANASIA

 91678-04 M 175 PPM NORMAL 1 11/21/13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91678-04 M 175 PPM DISPOSITION 4 11/24/13 10:29 P SCHEDULED EUTHANASIA

 91678-05 F 175 PPM NORMAL 1 11/21/13 11:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91678-05 F 175 PPM DISPOSITION 4 11/24/13 8:41 P FOUND DEAD

 91678-06 F 175 PPM NORMAL 1 11/21/13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91678-06 F 175 PPM DISPOSITION 4 11/24/13 10:29 P SCHEDULED EUTHANASIA

 91678-07 F 175 PPM NORMAL 1 11/21/13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 997 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 60

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91678-07 F 175 PPM DISPOSITION 4 11/24/13 10:29 P SCHEDULED EUTHANASIA

 91678-08 F 175 PPM NORMAL 1 11/21/13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91678-08 F 175 PPM DISPOSITION 4 11/24/13 10:29 P SCHEDULED EUTHANASIA

 91678-09 F 175 PPM NORMAL 1 11/21/13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91678-09 F 175 PPM DISPOSITION 4 11/24/13 10:29 P SCHEDULED EUTHANASIA

 91678-10 F 175 PPM NORMAL 1 11/21/13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91678-10 F 175 PPM DISPOSITION 4 11/24/13 10:29 P SCHEDULED EUTHANASIA

 91678-11 F 175 PPM NORMAL 1 11/21/13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91678-11 F 175 PPM DISPOSITION 4 11/24/13 10:29 P SCHEDULED EUTHANASIA

 91678-12 F 175 PPM NORMAL 1 11/21/13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91678-12 F 175 PPM DISPOSITION 4 11/24/13 10:29 P SCHEDULED EUTHANASIA

 91678-13 F 175 PPM NORMAL 1 11/21/13 11:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91678-13 F 175 PPM DISPOSITION 4 11/24/13 10:29 P SCHEDULED EUTHANASIA

 91678-14 F 175 PPM NORMAL 1 11/21/13 11:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91678-14 F 175 PPM DISPOSITION 4 11/24/13 10:29 P SCHEDULED EUTHANASIA

 91681-01 F 175 PPM DISPOSITION 0 11/29/13 7:40 P FOUND DEAD

 91681-02 F 175 PPM DISPOSITION 0 11/29/13 7:41 P FOUND DEAD

 91681-03 M 175 PPM DISPOSITION 1 11/30/13 6:38 P MISSING

 91681-03 M 175 PPM BODY/INTEGUMENT 0 11/29/13 7:41 P CYANOTIC

 91681-04 M 175 PPM NORMAL 1 11/30/13 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 12/03/13 7:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91681-04 M 175 PPM DISPOSITION 4 12/03/13 7:15 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 998 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 61

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91681-05 M 175 PPM NORMAL 1 11/30/13 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 12/03/13 7:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91681-05 M 175 PPM DISPOSITION 4 12/03/13 7:15 P SCHEDULED EUTHANASIA

 91681-06 M 175 PPM NORMAL 1 11/30/13 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 12/03/13 7:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91681-06 M 175 PPM DISPOSITION 4 12/03/13 7:15 P SCHEDULED EUTHANASIA

 91681-07 M 175 PPM NORMAL 1 11/30/13 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91681-07 M 175 PPM DISPOSITION 2 12/01/13 6:39 P MISSING

 91681-08 M 175 PPM DISPOSITION 1 11/30/13 6:38 P FOUND DEAD

 91681-09 M 175 PPM NORMAL 1 11/30/13 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 12/03/13 7:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91681-09 M 175 PPM DISPOSITION 4 12/03/13 7:15 P SCHEDULED EUTHANASIA

 91681-10 M 175 PPM NORMAL 1 11/30/13 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 12/03/13 7:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91681-10 M 175 PPM DISPOSITION 4 12/03/13 7:15 P SCHEDULED EUTHANASIA

 91681-11 F 175 PPM NORMAL 1 11/30/13 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91681-11 F 175 PPM DISPOSITION 4 12/03/13 7:15 P SCHEDULED EUTHANASIA

 91681-11 F 175 PPM BODY/INTEGUMENT 4 12/03/13 7:13 P SMALL STATURE

 91681-12 F 175 PPM NORMAL 1 11/30/13 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 12/03/13 7:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91681-12 F 175 PPM DISPOSITION 4 12/03/13 7:15 P SCHEDULED EUTHANASIA

 91681-13 F 175 PPM NORMAL 1 11/30/13 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 12/03/13 7:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91681-13 F 175 PPM DISPOSITION 4 12/03/13 7:15 P SCHEDULED EUTHANASIA

 91681-14 F 175 PPM NORMAL 1 11/30/13 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 12/03/13 7:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91681-14 F 175 PPM DISPOSITION 4 12/03/13 7:15 P SCHEDULED EUTHANASIA

 91681-15 F 175 PPM NORMAL 1 11/30/13 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 12/03/13 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91681-15 F 175 PPM DISPOSITION 4 12/03/13 7:15 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 999 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 62

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91682-01 M 175 PPM DISPOSITION 0 11/22/13 14:15 P FOUND DEAD

 91682-02 F 175 PPM DISPOSITION 3 11/25/13 10:21 P MISSING

 91682-02 F 175 PPM BODY/INTEGUMENT 0 11/22/13 14:17 P FILAMENTOUS TAIL

 1 11/23/13 7:55 P TAIL MISSING

 1 11/23/13 9:39 P TAIL MISSING

 91682-03 M 175 PPM DISPOSITION 1 11/23/13 7:55 P MISSING

 91682-03 M 175 PPM BODY/INTEGUMENT 0 11/22/13 14:17 P CYANOTIC

 91682-04 M 175 PPM NORMAL 1 11/23/13 9:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91682-04 M 175 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA

 91682-05 M 175 PPM NORMAL 1 11/23/13 9:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91682-05 M 175 PPM DISPOSITION 2 11/24/13 10:32 P MISSING

 91682-06 M 175 PPM NORMAL 1 11/23/13 9:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91682-06 M 175 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA

 91682-07 M 175 PPM NORMAL 1 11/23/13 9:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91682-07 M 175 PPM DISPOSITION 2 11/24/13 10:32 P MISSING

 91682-08 M 175 PPM NORMAL 1 11/23/13 9:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91682-08 M 175 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA

 91682-09 M 175 PPM NORMAL 1 11/23/13 9:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91682-09 M 175 PPM DISPOSITION 3 11/25/13 10:22 P MISSING

 91682-10 M 175 PPM NORMAL 1 11/23/13 9:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91682-10 M 175 PPM DISPOSITION 2 11/24/13 10:32 P MISSING

 91682-11 M 175 PPM NORMAL 1 11/23/13 9:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91682-11 M 175 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA

 91682-12 F 175 PPM NORMAL 1 11/23/13 9:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91682-12 F 175 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 1000 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 63

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91682-13 F 175 PPM NORMAL 1 11/23/13 9:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91682-13 F 175 PPM DISPOSITION 2 11/24/13 10:32 P MISSING

 91624-01 M 10000 PPM NORMAL 1 11/22/13 13:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91624-01 M 10000 PPM DISPOSITION 4 11/25/13 10:22 P SCHEDULED EUTHANASIA

 91624-02 M 10000 PPM NORMAL 1 11/22/13 13:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91624-02 M 10000 PPM DISPOSITION 4 11/25/13 10:22 P SCHEDULED EUTHANASIA

 91624-03 M 10000 PPM NORMAL 1 11/22/13 13:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91624-03 M 10000 PPM DISPOSITION 4 11/25/13 10:22 P SCHEDULED EUTHANASIA

 91624-04 M 10000 PPM NORMAL 1 11/22/13 13:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91624-04 M 10000 PPM DISPOSITION 4 11/25/13 10:22 P SCHEDULED EUTHANASIA

 91624-05 M 10000 PPM NORMAL 1 11/22/13 13:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91624-05 M 10000 PPM DISPOSITION 4 11/25/13 10:22 P SCHEDULED EUTHANASIA

 91624-06 M 10000 PPM NORMAL 1 11/22/13 13:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91624-06 M 10000 PPM DISPOSITION 4 11/25/13 10:22 P SCHEDULED EUTHANASIA

 91624-07 M 10000 PPM NORMAL 1 11/22/13 13:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91624-07 M 10000 PPM DISPOSITION 4 11/25/13 10:22 P SCHEDULED EUTHANASIA

 91624-08 M 10000 PPM NORMAL 1 11/22/13 13:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91624-08 M 10000 PPM DISPOSITION 4 11/25/13 10:22 P SCHEDULED EUTHANASIA

 91624-09 F 10000 PPM NORMAL 1 11/22/13 13:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91624-09 F 10000 PPM DISPOSITION 4 11/25/13 10:22 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 1001 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 64

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91624-10 F 10000 PPM NORMAL 1 11/22/13 13:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91624-10 F 10000 PPM DISPOSITION 4 11/25/13 10:22 P SCHEDULED EUTHANASIA

 91624-11 F 10000 PPM NORMAL 1 11/22/13 13:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91624-11 F 10000 PPM DISPOSITION 4 11/25/13 10:22 P SCHEDULED EUTHANASIA

 91624-12 F 10000 PPM NORMAL 1 11/22/13 13:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91624-12 F 10000 PPM DISPOSITION 4 11/25/13 10:23 P SCHEDULED EUTHANASIA

 91624-13 F 10000 PPM NORMAL 1 11/22/13 13:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91624-13 F 10000 PPM DISPOSITION 4 11/25/13 10:23 P SCHEDULED EUTHANASIA

 91625-01 M 10000 PPM NORMAL 1 11/23/13 9:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91625-01 M 10000 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA

 91625-02 M 10000 PPM NORMAL 1 11/23/13 9:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91625-02 M 10000 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA

 91625-03 M 10000 PPM NORMAL 1 11/23/13 9:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91625-03 M 10000 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA

 91625-04 M 10000 PPM NORMAL 1 11/23/13 9:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91625-04 M 10000 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA

 91625-05 M 10000 PPM NORMAL 1 11/23/13 9:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91625-05 M 10000 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA

 91625-06 F 10000 PPM NORMAL 1 11/23/13 9:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 1002 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 65

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91625-06 F 10000 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA

 91625-07 F 10000 PPM NORMAL 1 11/23/13 9:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91625-07 F 10000 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA

 91625-08 F 10000 PPM NORMAL 1 11/23/13 9:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91625-08 F 10000 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA

 91625-09 F 10000 PPM NORMAL 1 11/23/13 9:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91625-09 F 10000 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA

 91625-10 F 10000 PPM NORMAL 1 11/23/13 9:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91625-10 F 10000 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA

 91625-11 F 10000 PPM NORMAL 1 11/23/13 9:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91625-11 F 10000 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA

 91625-12 F 10000 PPM NORMAL 1 11/23/13 9:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91625-12 F 10000 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA

 91625-13 F 10000 PPM NORMAL 1 11/23/13 9:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91625-13 F 10000 PPM DISPOSITION 4 11/26/13 10:12 P SCHEDULED EUTHANASIA

 91625-14 F 10000 PPM NORMAL 1 11/23/13 9:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91625-14 F 10000 PPM DISPOSITION 4 11/26/13 10:13 P SCHEDULED EUTHANASIA

 91627-01 M 10000 PPM NORMAL 1 11/20/13 12:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91627-01 M 10000 PPM DISPOSITION 4 11/23/13 12:42 P SCHEDULED EUTHANASIA

 91627-02 M 10000 PPM NORMAL 1 11/20/13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 1003 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 66

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91627-02 M 10000 PPM NORMAL 4 11/23/13 9:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91627-02 M 10000 PPM DISPOSITION 4 11/23/13 12:42 P SCHEDULED EUTHANASIA

 91627-03 M 10000 PPM NORMAL 1 11/20/13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91627-03 M 10000 PPM DISPOSITION 4 11/23/13 12:42 P SCHEDULED EUTHANASIA

 91627-04 M 10000 PPM NORMAL 1 11/20/13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91627-04 M 10000 PPM DISPOSITION 4 11/23/13 12:42 P SCHEDULED EUTHANASIA

 91627-05 M 10000 PPM NORMAL 1 11/20/13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91627-05 M 10000 PPM DISPOSITION 4 11/23/13 12:42 P SCHEDULED EUTHANASIA

 91627-06 M 10000 PPM NORMAL 1 11/20/13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91627-06 M 10000 PPM DISPOSITION 4 11/23/13 12:42 P SCHEDULED EUTHANASIA

 91627-07 M 10000 PPM NORMAL 1 11/20/13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91627-07 M 10000 PPM DISPOSITION 4 11/23/13 12:42 P SCHEDULED EUTHANASIA

 91627-08 M 10000 PPM NORMAL 1 11/20/13 12:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91627-08 M 10000 PPM DISPOSITION 4 11/23/13 12:42 P SCHEDULED EUTHANASIA

 91627-09 F 10000 PPM NORMAL 1 11/20/13 12:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91627-09 F 10000 PPM DISPOSITION 4 11/23/13 12:42 P SCHEDULED EUTHANASIA

 91627-10 F 10000 PPM NORMAL 1 11/20/13 12:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91627-10 F 10000 PPM DISPOSITION 4 11/23/13 12:42 P SCHEDULED EUTHANASIA

 91627-11 F 10000 PPM NORMAL 1 11/20/13 12:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91627-11 F 10000 PPM DISPOSITION 4 11/23/13 12:42 P SCHEDULED EUTHANASIA

 91627-12 F 10000 PPM NORMAL 1 11/20/13 12:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 1004 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 67

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91627-12 F 10000 PPM NORMAL 4 11/23/13 9:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91627-12 F 10000 PPM DISPOSITION 4 11/23/13 12:42 P SCHEDULED EUTHANASIA

 91627-13 F 10000 PPM NORMAL 1 11/20/13 12:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91627-13 F 10000 PPM DISPOSITION 4 11/23/13 12:42 P SCHEDULED EUTHANASIA

 91634-01 M 10000 PPM NORMAL 1 11/23/13 9:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91634-01 M 10000 PPM DISPOSITION 4 11/26/13 10:13 P SCHEDULED EUTHANASIA

 91634-02 M 10000 PPM NORMAL 1 11/23/13 9:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91634-02 M 10000 PPM DISPOSITION 4 11/26/13 10:13 P SCHEDULED EUTHANASIA

 91634-03 M 10000 PPM NORMAL 1 11/23/13 9:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91634-03 M 10000 PPM DISPOSITION 4 11/26/13 10:13 P SCHEDULED EUTHANASIA

 91634-04 M 10000 PPM NORMAL 1 11/23/13 9:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91634-04 M 10000 PPM DISPOSITION 4 11/26/13 10:13 P SCHEDULED EUTHANASIA

 91634-05 M 10000 PPM NORMAL 1 11/23/13 9:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91634-05 M 10000 PPM DISPOSITION 4 11/26/13 10:13 P SCHEDULED EUTHANASIA

 91634-06 M 10000 PPM NORMAL 1 11/23/13 9:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91634-06 M 10000 PPM DISPOSITION 4 11/26/13 10:13 P SCHEDULED EUTHANASIA

 91634-07 F 10000 PPM NORMAL 1 11/23/13 9:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91634-07 F 10000 PPM DISPOSITION 4 11/26/13 10:13 P SCHEDULED EUTHANASIA

 91634-08 F 10000 PPM NORMAL 1 11/23/13 9:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91634-08 F 10000 PPM DISPOSITION 4 11/26/13 10:13 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 1005 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 68

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91634-09 F 10000 PPM NORMAL 1 11/23/13 9:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91634-09 F 10000 PPM DISPOSITION 4 11/26/13 10:13 P SCHEDULED EUTHANASIA

 91634-10 F 10000 PPM NORMAL 1 11/23/13 9:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91634-10 F 10000 PPM DISPOSITION 4 11/26/13 10:13 P SCHEDULED EUTHANASIA

 91634-11 F 10000 PPM NORMAL 1 11/23/13 9:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91634-11 F 10000 PPM DISPOSITION 4 11/26/13 10:13 P SCHEDULED EUTHANASIA

 91634-12 F 10000 PPM NORMAL 1 11/23/13 9:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91634-12 F 10000 PPM DISPOSITION 4 11/26/13 10:13 P SCHEDULED EUTHANASIA

 91634-13 F 10000 PPM NORMAL 1 11/23/13 9:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/26/13 9:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91634-13 F 10000 PPM DISPOSITION 4 11/26/13 10:13 P SCHEDULED EUTHANASIA

 91635-01 M 10000 PPM DISPOSITION 0 11/19/13 14:03 P FOUND DEAD

 91635-02 M 10000 PPM NORMAL 1 11/20/13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91635-02 M 10000 PPM DISPOSITION 4 11/23/13 13:23 P SCHEDULED EUTHANASIA

 91635-03 M 10000 PPM NORMAL 1 11/20/13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91635-03 M 10000 PPM DISPOSITION 4 11/23/13 13:23 P SCHEDULED EUTHANASIA

 91635-04 M 10000 PPM NORMAL 1 11/20/13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91635-04 M 10000 PPM DISPOSITION 4 11/23/13 13:23 P SCHEDULED EUTHANASIA

 91635-05 M 10000 PPM NORMAL 1 11/20/13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91635-05 M 10000 PPM DISPOSITION 4 11/23/13 13:23 P SCHEDULED EUTHANASIA

 91635-06 M 10000 PPM NORMAL 1 11/20/13 12:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 1006 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 69

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91635-06 M 10000 PPM NORMAL 4 11/23/13 9:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91635-06 M 10000 PPM DISPOSITION 4 11/23/13 13:23 P SCHEDULED EUTHANASIA

 91635-07 M 10000 PPM NORMAL 1 11/20/13 12:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91635-07 M 10000 PPM DISPOSITION 4 11/23/13 13:23 P SCHEDULED EUTHANASIA

 91635-08 F 10000 PPM NORMAL 1 11/20/13 12:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91635-08 F 10000 PPM DISPOSITION 4 11/23/13 13:23 P SCHEDULED EUTHANASIA

 91635-09 F 10000 PPM NORMAL 1 11/20/13 12:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91635-09 F 10000 PPM DISPOSITION 4 11/23/13 13:23 P SCHEDULED EUTHANASIA

 91635-10 F 10000 PPM NORMAL 1 11/20/13 12:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91635-10 F 10000 PPM DISPOSITION 4 11/23/13 13:23 P SCHEDULED EUTHANASIA

 91635-11 F 10000 PPM NORMAL 1 11/20/13 12:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91635-11 F 10000 PPM DISPOSITION 4 11/23/13 13:23 P SCHEDULED EUTHANASIA

 91635-12 F 10000 PPM NORMAL 1 11/20/13 12:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91635-12 F 10000 PPM DISPOSITION 4 11/23/13 13:23 P SCHEDULED EUTHANASIA

 91635-13 F 10000 PPM NORMAL 1 11/20/13 12:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91635-13 F 10000 PPM DISPOSITION 4 11/23/13 13:23 P SCHEDULED EUTHANASIA

 91638-01 M 10000 PPM NORMAL 1 11/22/13 13:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91638-01 M 10000 PPM DISPOSITION 4 11/25/13 10:24 P SCHEDULED EUTHANASIA

 91638-02 M 10000 PPM NORMAL 1 11/22/13 13:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91638-02 M 10000 PPM DISPOSITION 4 11/25/13 10:24 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 1007 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 70

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91638-03 M 10000 PPM NORMAL 1 11/22/13 13:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91638-03 M 10000 PPM DISPOSITION 4 11/25/13 10:24 P SCHEDULED EUTHANASIA

 91638-04 M 10000 PPM NORMAL 1 11/22/13 13:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91638-04 M 10000 PPM DISPOSITION 4 11/25/13 10:24 P SCHEDULED EUTHANASIA

 91638-05 M 10000 PPM NORMAL 1 11/22/13 13:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91638-05 M 10000 PPM DISPOSITION 4 11/25/13 10:24 P SCHEDULED EUTHANASIA

 91638-06 M 10000 PPM NORMAL 1 11/22/13 13:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91638-06 M 10000 PPM DISPOSITION 4 11/25/13 10:24 P SCHEDULED EUTHANASIA

 91638-07 M 10000 PPM NORMAL 1 11/22/13 13:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91638-07 M 10000 PPM DISPOSITION 4 11/25/13 10:24 P SCHEDULED EUTHANASIA

 91638-08 M 10000 PPM NORMAL 1 11/22/13 13:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91638-08 M 10000 PPM DISPOSITION 4 11/25/13 10:24 P SCHEDULED EUTHANASIA

 91638-09 M 10000 PPM NORMAL 1 11/22/13 13:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91638-09 M 10000 PPM DISPOSITION 4 11/25/13 10:24 P SCHEDULED EUTHANASIA

 91638-10 F 10000 PPM NORMAL 1 11/22/13 13:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91638-10 F 10000 PPM DISPOSITION 4 11/25/13 10:24 P SCHEDULED EUTHANASIA

 91638-11 F 10000 PPM NORMAL 1 11/22/13 13:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91638-11 F 10000 PPM DISPOSITION 4 11/25/13 10:24 P SCHEDULED EUTHANASIA

 91638-12 F 10000 PPM NORMAL 1 11/22/13 13:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91638-12 F 10000 PPM DISPOSITION 4 11/25/13 10:25 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 1008 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 71

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91638-13 F 10000 PPM NORMAL 1 11/22/13 13:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91638-13 F 10000 PPM DISPOSITION 4 11/25/13 10:25 P SCHEDULED EUTHANASIA

 91638-14 F 10000 PPM NORMAL 4 11/25/13 8:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91638-14 F 10000 PPM DISPOSITION 4 11/25/13 10:25 P SCHEDULED EUTHANASIA

 91638-14 F 10000 PPM BODY/INTEGUMENT 1 11/22/13 13:32 P SUBCUTANEOUS HEMORRHAGE FACIAL AREA

 91638-15 F 10000 PPM NORMAL 1 11/22/13 13:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91638-15 F 10000 PPM DISPOSITION 4 11/25/13 10:25 P SCHEDULED EUTHANASIA

 91638-16 F 10000 PPM NORMAL 1 11/22/13 13:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/25/13 8:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91638-16 F 10000 PPM DISPOSITION 4 11/25/13 10:25 P SCHEDULED EUTHANASIA

 91652-01 M 10000 PPM DISPOSITION 0 11/19/13 14:15 P FOUND DEAD

 91652-02 U 10000 PPM DISPOSITION 0 11/19/13 14:15 P FOUND DEAD; PARTIALLY CANNIBALIZED

 91652-03 M 10000 PPM NORMAL 1 11/20/13 12:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91652-03 M 10000 PPM DISPOSITION 4 11/23/13 13:24 P SCHEDULED EUTHANASIA

 91652-04 M 10000 PPM NORMAL 1 11/20/13 12:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91652-04 M 10000 PPM DISPOSITION 4 11/23/13 13:24 P SCHEDULED EUTHANASIA

 91652-05 M 10000 PPM NORMAL 1 11/20/13 12:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91652-05 M 10000 PPM DISPOSITION 4 11/23/13 13:24 P SCHEDULED EUTHANASIA

 91652-06 M 10000 PPM NORMAL 1 11/20/13 12:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91652-06 M 10000 PPM DISPOSITION 4 11/23/13 13:24 P SCHEDULED EUTHANASIA

 91652-07 M 10000 PPM NORMAL 1 11/20/13 12:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91652-07 M 10000 PPM DISPOSITION 4 11/23/13 13:24 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 1009 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 72

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91652-08 M 10000 PPM NORMAL 1 11/20/13 12:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91652-08 M 10000 PPM DISPOSITION 4 11/23/13 13:24 P SCHEDULED EUTHANASIA

 91652-09 M 10000 PPM NORMAL 1 11/20/13 12:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91652-09 M 10000 PPM DISPOSITION 4 11/23/13 13:24 P SCHEDULED EUTHANASIA

 91652-10 M 10000 PPM NORMAL 1 11/20/13 12:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91652-10 M 10000 PPM DISPOSITION 4 11/23/13 13:24 P SCHEDULED EUTHANASIA

 91652-11 F 10000 PPM NORMAL 1 11/20/13 12:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91652-11 F 10000 PPM DISPOSITION 4 11/23/13 13:24 P SCHEDULED EUTHANASIA

 91652-11 F 10000 PPM BODY/INTEGUMENT 4 11/23/13 9:55 P SMALL STATURE

 91652-12 F 10000 PPM NORMAL 1 11/20/13 12:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91652-12 F 10000 PPM DISPOSITION 4 11/23/13 13:24 P SCHEDULED EUTHANASIA

 91652-13 F 10000 PPM NORMAL 1 11/20/13 12:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91652-13 F 10000 PPM DISPOSITION 4 11/23/13 13:24 P SCHEDULED EUTHANASIA

 91655-01 M 10000 PPM NORMAL 1 11/20/13 12:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91655-01 M 10000 PPM DISPOSITION 4 11/23/13 13:25 P SCHEDULED EUTHANASIA

 91655-02 M 10000 PPM NORMAL 1 11/20/13 12:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91655-02 M 10000 PPM DISPOSITION 4 11/23/13 13:25 P SCHEDULED EUTHANASIA

 91655-03 M 10000 PPM NORMAL 1 11/20/13 12:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91655-03 M 10000 PPM DISPOSITION 4 11/23/13 13:25 P SCHEDULED EUTHANASIA

 91655-04 M 10000 PPM NORMAL 1 11/20/13 12:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 1010 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 73

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91655-04 M 10000 PPM DISPOSITION 4 11/23/13 13:25 P SCHEDULED EUTHANASIA

 91655-05 F 10000 PPM NORMAL 1 11/20/13 12:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91655-05 F 10000 PPM DISPOSITION 4 11/23/13 13:25 P SCHEDULED EUTHANASIA

 91655-06 F 10000 PPM NORMAL 1 11/20/13 12:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91655-06 F 10000 PPM DISPOSITION 4 11/23/13 13:25 P SCHEDULED EUTHANASIA

 91655-07 F 10000 PPM NORMAL 1 11/20/13 12:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91655-07 F 10000 PPM DISPOSITION 4 11/23/13 13:25 P SCHEDULED EUTHANASIA

 91655-08 F 10000 PPM NORMAL 1 11/20/13 12:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91655-08 F 10000 PPM DISPOSITION 2 11/21/13 11:56 P FOUND DEAD

 91655-09 F 10000 PPM NORMAL 1 11/20/13 12:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91655-09 F 10000 PPM DISPOSITION 4 11/23/13 13:25 P SCHEDULED EUTHANASIA

 91655-10 F 10000 PPM NORMAL 1 11/20/13 12:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91655-10 F 10000 PPM DISPOSITION 4 11/23/13 13:25 P SCHEDULED EUTHANASIA

 91655-11 F 10000 PPM NORMAL 1 11/20/13 12:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91655-11 F 10000 PPM DISPOSITION 4 11/23/13 13:25 P SCHEDULED EUTHANASIA

 91655-12 F 10000 PPM NORMAL 1 11/20/13 12:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91655-12 F 10000 PPM DISPOSITION 4 11/23/13 13:25 P SCHEDULED EUTHANASIA

 91655-13 F 10000 PPM DISPOSITION 1 11/20/13 12:48 P FOUND DEAD

 91658-01 M 10000 PPM NORMAL 1 11/21/13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91658-01 M 10000 PPM DISPOSITION 4 11/24/13 10:35 P SCHEDULED EUTHANASIA

 91658-02 M 10000 PPM NORMAL 1 11/21/13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 1011 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 74

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91658-02 M 10000 PPM NORMAL 4 11/24/13 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91658-02 M 10000 PPM DISPOSITION 4 11/24/13 10:35 P SCHEDULED EUTHANASIA

 91658-03 M 10000 PPM NORMAL 1 11/21/13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91658-03 M 10000 PPM DISPOSITION 4 11/24/13 10:35 P SCHEDULED EUTHANASIA

 91658-04 M 10000 PPM NORMAL 1 11/21/13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91658-04 M 10000 PPM DISPOSITION 4 11/24/13 10:35 P SCHEDULED EUTHANASIA

 91658-05 M 10000 PPM NORMAL 1 11/21/13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91658-05 M 10000 PPM DISPOSITION 4 11/24/13 10:35 P SCHEDULED EUTHANASIA

 91658-06 M 10000 PPM NORMAL 1 11/21/13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91658-06 M 10000 PPM DISPOSITION 4 11/24/13 10:35 P SCHEDULED EUTHANASIA

 91658-07 M 10000 PPM NORMAL 1 11/21/13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91658-07 M 10000 PPM DISPOSITION 4 11/24/13 10:35 P SCHEDULED EUTHANASIA

 91658-08 M 10000 PPM NORMAL 1 11/21/13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91658-08 M 10000 PPM DISPOSITION 4 11/24/13 10:35 P SCHEDULED EUTHANASIA

 91658-09 F 10000 PPM NORMAL 1 11/21/13 12:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91658-09 F 10000 PPM DISPOSITION 4 11/24/13 10:35 P SCHEDULED EUTHANASIA

 91658-10 F 10000 PPM NORMAL 1 11/21/13 12:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91658-10 F 10000 PPM DISPOSITION 4 11/24/13 10:35 P SCHEDULED EUTHANASIA

 91658-11 F 10000 PPM NORMAL 1 11/21/13 12:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91658-11 F 10000 PPM DISPOSITION 4 11/24/13 10:35 P SCHEDULED EUTHANASIA

 91658-12 F 10000 PPM NORMAL 1 11/21/13 12:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 1012 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 75

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91658-12 F 10000 PPM NORMAL 4 11/24/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91658-12 F 10000 PPM DISPOSITION 4 11/24/13 10:35 P SCHEDULED EUTHANASIA

 91658-13 F 10000 PPM NORMAL 1 11/21/13 12:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91658-13 F 10000 PPM DISPOSITION 4 11/24/13 10:35 P SCHEDULED EUTHANASIA

 91667-01 M 10000 PPM NORMAL 1 11/21/13 12:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91667-01 M 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA

 91667-02 M 10000 PPM NORMAL 1 11/21/13 12:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91667-02 M 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA

 91667-03 M 10000 PPM NORMAL 1 11/21/13 12:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91667-03 M 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA

 91667-04 M 10000 PPM NORMAL 1 11/21/13 12:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91667-04 M 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA

 91667-05 M 10000 PPM NORMAL 1 11/21/13 12:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91667-05 M 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA

 91667-06 F 10000 PPM NORMAL 1 11/21/13 12:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91667-06 F 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA

 91667-07 F 10000 PPM NORMAL 1 11/21/13 12:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91667-07 F 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA

 91667-08 F 10000 PPM NORMAL 1 11/21/13 12:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91667-08 F 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 1013 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 76

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91667-09 F 10000 PPM NORMAL 1 11/21/13 12:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91667-09 F 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA

 91667-10 F 10000 PPM NORMAL 1 11/21/13 12:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91667-10 F 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA

 91667-11 F 10000 PPM NORMAL 1 11/21/13 12:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91667-11 F 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA

 91667-12 F 10000 PPM NORMAL 1 11/21/13 12:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91667-12 F 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA

 91667-13 F 10000 PPM NORMAL 1 11/21/13 12:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91667-13 F 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA

 91667-14 F 10000 PPM NORMAL 1 11/21/13 12:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91667-14 F 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA

 91667-15 F 10000 PPM NORMAL 1 11/21/13 12:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91667-15 F 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA

 91667-16 F 10000 PPM NORMAL 1 11/21/13 12:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91667-16 F 10000 PPM DISPOSITION 4 11/24/13 10:36 P SCHEDULED EUTHANASIA

 91668-01 U 10000 PPM DISPOSITION 0 11/20/13 14:25 P FOUND DEAD; PARTIALLY CANNIBALIZED

 91668-02 F 10000 PPM DISPOSITION 0 11/20/13 14:25 P FOUND DEAD

 91668-03 M 10000 PPM NORMAL 1 11/21/13 12:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91668-03 M 10000 PPM DISPOSITION 4 11/24/13 10:37 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 1014 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 77

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91668-04 M 10000 PPM NORMAL 1 11/21/13 12:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91668-04 M 10000 PPM DISPOSITION 4 11/24/13 10:37 P SCHEDULED EUTHANASIA

 91668-05 M 10000 PPM NORMAL 1 11/21/13 12:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91668-05 M 10000 PPM DISPOSITION 4 11/24/13 10:37 P SCHEDULED EUTHANASIA

 91668-06 M 10000 PPM NORMAL 1 11/21/13 12:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91668-06 M 10000 PPM DISPOSITION 4 11/24/13 10:37 P SCHEDULED EUTHANASIA

 91668-07 M 10000 PPM NORMAL 1 11/21/13 12:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91668-07 M 10000 PPM DISPOSITION 4 11/24/13 10:37 P SCHEDULED EUTHANASIA

 91668-08 M 10000 PPM NORMAL 1 11/21/13 12:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91668-08 M 10000 PPM DISPOSITION 4 11/24/13 10:37 P SCHEDULED EUTHANASIA

 91668-09 M 10000 PPM NORMAL 1 11/21/13 12:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91668-09 M 10000 PPM DISPOSITION 4 11/24/13 10:37 P SCHEDULED EUTHANASIA

 91668-10 M 10000 PPM NORMAL 1 11/21/13 12:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91668-10 M 10000 PPM DISPOSITION 4 11/24/13 10:37 P SCHEDULED EUTHANASIA

 91668-11 M 10000 PPM NORMAL 1 11/21/13 12:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91668-11 M 10000 PPM DISPOSITION 4 11/24/13 10:37 P SCHEDULED EUTHANASIA

 91668-12 F 10000 PPM NORMAL 1 11/21/13 12:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91668-12 F 10000 PPM DISPOSITION 4 11/24/13 10:37 P SCHEDULED EUTHANASIA

 91668-13 F 10000 PPM NORMAL 1 11/21/13 12:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91668-13 F 10000 PPM DISPOSITION 4 11/24/13 10:37 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 1015 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 78

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91668-14 F 10000 PPM NORMAL 1 11/21/13 12:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91668-14 F 10000 PPM DISPOSITION 4 11/24/13 10:37 P SCHEDULED EUTHANASIA

 91668-15 F 10000 PPM NORMAL 1 11/21/13 12:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/24/13 8:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91668-15 F 10000 PPM DISPOSITION 4 11/24/13 10:37 P SCHEDULED EUTHANASIA

 91680-01 M 10000 PPM NORMAL 1 11/20/13 12:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91680-01 M 10000 PPM DISPOSITION 4 11/23/13 13:26 P SCHEDULED EUTHANASIA

 91680-02 M 10000 PPM NORMAL 1 11/20/13 12:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91680-02 M 10000 PPM DISPOSITION 4 11/23/13 13:26 P SCHEDULED EUTHANASIA

 91680-03 M 10000 PPM NORMAL 1 11/20/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 9:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91680-03 M 10000 PPM DISPOSITION 4 11/23/13 13:26 P SCHEDULED EUTHANASIA

 91680-04 M 10000 PPM NORMAL 1 11/20/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91680-04 M 10000 PPM DISPOSITION 4 11/23/13 13:26 P SCHEDULED EUTHANASIA

 91680-05 M 10000 PPM NORMAL 1 11/20/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91680-05 M 10000 PPM DISPOSITION 4 11/23/13 13:26 P SCHEDULED EUTHANASIA

 91680-06 M 10000 PPM NORMAL 1 11/20/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91680-06 M 10000 PPM DISPOSITION 4 11/23/13 13:26 P SCHEDULED EUTHANASIA

 91680-07 M 10000 PPM NORMAL 1 11/20/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91680-07 M 10000 PPM DISPOSITION 4 11/23/13 13:26 P SCHEDULED EUTHANASIA

 91680-08 F 10000 PPM NORMAL 1 11/20/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

Page 1016 of 1107
 TABLE A54 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 79

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 ANIMAL SEX GROUP CATEGORY PND DATE TIME GRADE OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------

 91680-08 F 10000 PPM DISPOSITION 4 11/23/13 13:26 P SCHEDULED EUTHANASIA

 91680-09 F 10000 PPM NORMAL 1 11/20/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91680-09 F 10000 PPM DISPOSITION 4 11/23/13 13:26 P SCHEDULED EUTHANASIA

 91680-10 F 10000 PPM NORMAL 1 11/20/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 10:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91680-10 F 10000 PPM DISPOSITION 4 11/23/13 13:26 P SCHEDULED EUTHANASIA

 91680-11 F 10000 PPM NORMAL 1 11/20/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 10:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91680-11 F 10000 PPM DISPOSITION 4 11/23/13 13:26 P SCHEDULED EUTHANASIA

 91680-12 F 10000 PPM NORMAL 1 11/20/13 12:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 10:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91680-12 F 10000 PPM DISPOSITION 4 11/23/13 13:26 P SCHEDULED EUTHANASIA

 91680-13 F 10000 PPM NORMAL 1 11/20/13 12:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 10:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91680-13 F 10000 PPM DISPOSITION 4 11/23/13 13:26 P SCHEDULED EUTHANASIA

 91680-14 F 10000 PPM NORMAL 1 11/20/13 12:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 10:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91680-14 F 10000 PPM DISPOSITION 4 11/23/13 13:26 P SCHEDULED EUTHANASIA

 91680-15 F 10000 PPM NORMAL 1 11/20/13 12:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 4 11/23/13 10:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS

 91680-15 F 10000 PPM DISPOSITION 4 11/23/13 13:27 P SCHEDULED EUTHANASIA

-----------------------------------------------------------------------------------------------------------------------------------

GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PND = POSTNATAL DAY

 PPOCRDv1.05

 01/07/2014

 R:01/20/2014

Page 1017 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91629-01 M 5.9 7.5

 91629-02 M 5.5 7.2

 91629-03 M 5.5 7.5

 91629-04 M 5.3 6.7

 91629-05 M 5.4 7.0

 91629-06 M 5.9 8.0

 91629-07 M 4.2 NA

 91629-08 M 4.7 6.1

 91629-09 M 5.9 7.7

 91629-10 M 5.7 7.4

 91629-11 M 5.8 7.5

 91629-12 M 5.9 7.8

 91629-13 F 5.6 7.4

 91629-14 F 5.8 7.7

 91629-15 F 5.4 6.7

 91629-16 F 5.7 7.6

 MALES MEAN 5.5 7.3

 FEMALES MEAN 5.6 7.4

 91630-03 M 7.0 10.6

 91630-04 M 7.0 10.5

 91630-05 M 7.2 10.3

 91630-06 M 6.8 10.0

 91630-07 M 7.2 10.5

 91630-08 M 7.0 10.4

 NA = NOT APPLICABLE

Page 1018 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91630-09 F 6.6 9.6

 91630-10 F 6.3 9.4

 91630-11 F 7.0 10.2

 91630-12 F 6.4 9.3

 91630-13 F 6.9 10.3

 91630-14 F 6.8 9.5

 MALES MEAN 7.0 10.4

 FEMALES MEAN 6.7 9.7

 91633-01 M 6.5 8.0

 91633-02 M 6.2 8.5

 91633-03 M 6.8 8.9

 91633-04 M 5.8 7.1

 91633-05 M 6.6 8.0

 91633-06 M 6.3 8.1

 91633-07 M 6.1 7.1

 91633-08 F 6.3 8.3

 91633-09 F 5.9 6.9

 91633-10 F 6.0 8.5

 91633-11 F 5.4 7.4

 91633-12 F 6.0 8.0

 91633-13 F 5.6 6.3

 91633-14 F 5.8 7.7

Page 1019 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91633-15 F 5.5 7.1

 MALES MEAN 6.3 8.0

 FEMALES MEAN 5.8 7.5

 91637-01 M 6.4 8.8

 91637-02 M 6.6 8.9

 91637-03 M 6.6 8.4

 91637-04 M 6.4 8.9

 91637-05 M 3.2 NA

 91637-06 F 5.9 8.7

 91637-07 F 6.3 8.7

 91637-08 F 6.3 8.7

 91637-09 F 6.2 8.9

 91637-10 F 6.0 7.7

 91637-11 F 5.7 8.5

 91637-12 F 5.9 8.5

 91637-13 F 5.9 8.4

 MALES MEAN 5.8 8.8

 FEMALES MEAN 6.0 8.5

 91639-02 M 7.6 11.2

 91639-03 M 7.7 11.4

 91639-04 M 7.6 11.2

 91639-05 M 7.3 11.4

 NA = NOT APPLICABLE

Page 1020 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91639-06 M 7.1 9.9

 91639-07 M 8.6 12.3

 91639-08 M 6.9 9.7

 91639-09 F 7.3 10.4

 91639-10 F 6.9 9.8

 MALES MEAN 7.5 11.0

 FEMALES MEAN 7.1 10.1

 91644-01 M 5.5 7.2

 91644-02 M 5.5 7.1

 91644-03 M 5.5 7.2

 91644-04 M 5.5 6.2

 91644-05 M 5.7 7.2

 91644-06 M 5.5 6.7

 91644-07 M 5.5 7.3

 91644-08 M 5.9 7.3

 91644-09 M 5.6 6.9

 91644-10 M 5.5 6.7

 91644-11 F 5.1 6.4

 91644-12 F 5.1 6.2

 91644-13 F 4.6 5.6

 91644-14 F 5.3 6.7

 91644-15 F 5.4 6.6

 91644-16 F 5.3 6.5

Page 1021 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91644-17 F 5.5 NA

 MALES MEAN 5.6 7.0

 FEMALES MEAN 5.2 6.3

 91645-01 M 6.6 9.5

 91645-02 M 6.6 9.4

 91645-03 M 6.8 9.8

 91645-04 M 6.4 9.6

 91645-05 M 7.3 11.1

 91645-06 M 6.4 9.3

 91645-07 M 6.6 9.7

 91645-09 M 6.7 10.3

 91645-10 F 6.5 9.7

 91645-11 F 6.1 8.3

 91645-12 F 5.9 8.9

 91645-13 F 6.2 9.3

 91645-14 F 6.5 9.6

 91645-15 F 6.7 9.6

 91645-16 F 7.2 10.7

 MALES MEAN 6.7 9.8

 FEMALES MEAN 6.4 9.4

 91648-02 M 7.7 11.2

 91648-03 M 8.9 12.5

 NA = NOT APPLICABLE

Page 1022 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91648-04 M 7.7 11.5

 91648-05 M 7.7 11.4

 91648-06 M 8.0 11.4

 91648-07 M 6.9 10.2

 91648-08 M 8.0 12.2

 91648-09 M 7.7 11.3

 91648-10 F 7.8 11.2

 91648-11 F 7.8 10.8

 91648-12 F 7.6 11.3

 91648-13 F 7.0 10.5

 91648-14 F 7.5 11.3

 MALES MEAN 7.8 11.5

 FEMALES MEAN 7.5 11.0

 91653-01 M 7.9 9.8

 91653-02 M 7.8 10.9

 91653-03 M 6.1 7.3

 91653-04 M 7.7 10.4

 91653-05 M 7.9 10.3

 91653-06 M 7.7 9.8

 91653-07 F 7.1 9.1

 91653-08 F 7.3 9.7

 91653-09 F 7.7 10.0

 91653-10 F 5.7 7.0

 91653-11 F 7.0 9.7

Page 1023 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91653-12 F 7.8 9.6

 91653-13 F 7.2 9.2

 91653-14 F 7.3 9.7

 91653-15 F 7.4 8.8

 MALES MEAN 7.5 9.8

 FEMALES MEAN 7.2 9.2

 91660-02 M 8.4 11.8

 91660-03 M 7.7 11.3

 91660-04 M 7.3 10.3

 91660-05 M 7.9 11.8

 91660-06 M 8.6 12.4

 91660-07 M 8.3 11.7

 91660-08 M 8.3 12.1

 91660-09 M 8.4 12.0

 91660-10 F 7.6 10.6

 91660-11 F 7.3 10.1

 91660-12 F 7.6 10.2

 91660-13 F 7.9 11.0

 91660-14 F 6.7 9.7

 MALES MEAN 8.1 11.7

 FEMALES MEAN 7.4 10.3

 91670-01 M 6.7 8.5

Page 1024 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91670-02 M 7.0 9.1

 91670-03 M 6.8 9.1

 91670-04 M 7.1 9.3

 91670-05 M 7.8 10.5

 91670-06 M 7.1 9.4

 91670-07 M 5.7 7.9

 91670-08 M 7.1 9.2

 91670-09 F 6.5 8.8

 91670-10 F 6.8 9.6

 91670-11 F 6.7 7.9

 91670-12 F 6.8 8.8

 91670-13 F 7.1 9.7

 91670-14 F 7.1 9.0

 MALES MEAN 6.9 9.1

 FEMALES MEAN 6.8 9.0

 91672-02 M 7.2 10.7

 91672-03 M 7.4 10.8

 91672-04 M 7.0 11.2

 91672-05 M 7.8 9.8

 91672-06 M 7.4 12.2

 91672-07 M 7.2 NA

 91672-08 M 6.9 11.3

 91672-09 F 7.5 12.3

 91672-10 F 7.7 11.9

 NA = NOT APPLICABLE

Page 1025 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91672-11 F 7.5 NA

 91672-12 F 7.1 10.6

 91672-13 F 7.0 11.1

 91672-14 F 7.0 9.4

 MALES MEAN 7.3 11.0

 FEMALES MEAN 7.3 11.1

 MALES MEAN 6.8 9.6

 S.D. 0.87 1.60

 S.E. 0.25 0.46

 N 12 12

 FEMALES MEAN 6.6 9.1

 S.D. 0.77 1.48

 S.E. 0.22 0.43

 N 12 12

 NA = NOT APPLICABLE

Page 1026 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91632-01 M 7.5 9.2

 91632-02 M 7.6 8.5

 91632-03 M 7.3 9.2

 91632-04 M 7.6 9.7

 91632-05 F 7.0 8.7

 91632-06 F 7.0 8.7

 91632-07 F 6.8 8.5

 91632-08 F 7.3 8.7

 91632-09 F 7.2 8.9

 91632-10 F 6.5 8.6

 91632-11 F 6.9 8.7

 91632-12 F 7.8 9.5

 91632-13 F 7.2 8.9

 91632-14 F 7.8 9.2

 91632-15 F 5.9 NA

 MALES MEAN 7.5 9.2

 FEMALES MEAN 7.0 8.8

 91640-03 F 4.7 6.5

 91640-04 M 8.2 12.0

 91640-05 M 7.7 10.1

 91640-06 M 7.9 11.2

 91640-07 F 8.2 11.7

 91640-08 F 8.2 11.7

 91640-09 F 7.2 10.3

 NA = NOT APPLICABLE

Page 1027 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 11

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91640-10 F 7.1 10.7

 91640-11 F 7.4 9.9

 91640-12 F 7.9 11.5

 MALES MEAN 7.9 11.1

 FEMALES MEAN 7.2 10.3

 91642-01 M 7.7 9.2

 91642-02 M 8.0 10.1

 91642-03 M 7.4 9.4

 91642-04 M 7.1 9.3

 91642-05 F 7.6 9.6

 91642-06 F 7.0 9.2

 91642-07 F 7.3 9.6

 91642-08 F 6.8 8.2

 91642-09 F 7.6 9.0

 91642-10 F 7.1 9.0

 91642-11 F 7.8 9.4

 91642-12 F 6.2 6.2

 91642-13 F 7.0 8.6

 91642-14 F 6.4 8.6

Page 1028 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 12

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91642-15 M 7.9 9.5

 MALES MEAN 7.6 9.5

 FEMALES MEAN 7.1 8.7

 91647-03 M 8.0 10.3

 91647-04 M 7.3 9.7

 91647-05 M 7.9 9.8

 91647-06 M 7.6 9.7

 91647-07 M 7.2 9.3

 91647-08 M 7.8 9.7

 91647-09 F 7.4 9.8

 91647-10 F 7.9 9.5

 91647-11 F 7.0 8.8

 91647-12 F 6.1 8.3

 91647-13 F 5.5 7.5

 MALES MEAN 7.6 9.8

 FEMALES MEAN 6.8 8.8

 91651-01 M 9.2 12.4

 91651-02 M 8.9 11.5

 91651-03 M 8.4 10.3

 91651-04 M 8.9 11.8

 91651-05 M 8.6 11.1

 91651-06 M 8.1 9.7

Page 1029 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 13

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91651-07 M 8.9 11.4

 91651-08 F 8.2 8.3

 91651-09 F 8.2 10.2

 91651-10 F 7.9 11.0

 91651-11 F 8.7 10.7

 91651-12 F 8.5 10.5

 MALES MEAN 8.7 11.2

 FEMALES MEAN 8.3 10.1

 91659-02 M 8.5 9.6

 91659-03 M 9.2 11.8

 91659-04 M 8.8 11.0

 91659-05 M 9.2 10.7

 91659-06 M 8.6 11.4

 91659-07 M 8.9 11.5

 91659-08 F 8.8 11.0

 91659-09 F 8.6 10.3

 91659-10 F 8.4 10.5

 91659-11 F 8.5 10.4

 91659-12 F 8.2 10.2

Page 1030 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 14

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91659-13 F 8.1 10.5

 MALES MEAN 8.9 11.0

 FEMALES MEAN 8.4 10.5

 91661-01 M 6.5 8.9

 91661-02 M 7.4 9.5

 91661-03 M 7.1 10.2

 91661-04 M 6.6 9.8

 91661-05 M 6.7 9.7

 91661-06 M 7.0 10.2

 91661-07 M 6.3 9.5

 91661-08 M 6.6 9.2

 91661-09 M 7.3 9.9

 91661-10 M 6.6 9.6

 91661-11 M 6.3 8.5

 91661-12 F 6.1 8.8

 91661-13 F 4.0 5.5

 91661-14 F 5.5 7.3

 91661-15 F 5.9 8.7

 91661-16 F 6.7 9.0

Page 1031 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 15

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91661-17 F 6.5 9.4

 MALES MEAN 6.8 9.5

 FEMALES MEAN 5.8 8.1

 91663-01 M 7.5 9.8

 91663-03 M 8.1 10.4

 91663-04 M 8.3 10.8

 91663-05 M 8.3 8.4

 91663-06 M 7.6 10.0

 91663-07 M 8.2 10.5

 91663-08 F 8.1 11.0

 91663-09 F 8.4 10.3

 91663-10 F 8.3 11.3

 91663-11 F 7.2 9.4

 91663-12 F 7.2 9.3

 91663-13 F 8.1 10.6

 91663-14 F 7.1 NA

 91663-15 F 8.4 11.2

 MALES MEAN 8.0 10.0

 FEMALES MEAN 7.9 10.4

 91669-01 M 7.3 9.9

 91669-02 M 6.3 7.2

 91669-03 M 6.9 7.1

 NA = NOT APPLICABLE

Page 1032 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 16

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91669-04 M 7.7 10.1

 91669-05 M 7.6 NA

 91669-06 M 7.4 10.2

 91669-07 M 7.8 10.7

 91669-08 M 7.1 9.7

 91669-09 M 7.3 8.9

 91669-10 F 7.6 10.4

 91669-11 F 6.5 NA

 91669-12 F 6.7 9.3

 91669-13 F 6.9 9.3

 91669-14 F 6.6 9.1

 91669-15 F 6.7 NA

 91669-16 F 6.2 NA

 MALES MEAN 7.3 9.2

 FEMALES MEAN 6.7 9.5

 91673-01 M 8.3 10.2

 91673-02 M 7.5 8.9

 91673-03 M 7.4 9.0

 91673-04 M 7.8 9.7

 91673-05 M 7.0 8.4

 91673-06 M 7.8 9.5

 91673-07 F 7.1 8.6

 91673-08 F 7.0 8.9

 91673-09 F 7.2 8.9

 NA = NOT APPLICABLE

Page 1033 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 17

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91673-10 F 7.1 8.9

 91673-11 F 6.7 8.7

 91673-12 F 6.6 8.6

 91673-13 F 6.4 8.4

 91673-14 F 6.6 8.7

 91673-15 F 7.2 8.3

 91673-16 F 6.3 7.2

 MALES MEAN 7.6 9.3

 FEMALES MEAN 6.8 8.5

 91683-01 M 8.3 11.6

 91683-02 M 8.3 11.0

 91683-03 M 7.8 11.1

 91683-04 M 7.3 10.4

 91683-05 M 8.2 11.0

 91683-06 M 7.8 10.5

 91683-07 F 7.7 10.8

 91683-08 F 7.8 10.7

 91683-09 F 7.8 10.9

 91683-10 F 6.8 9.2

 91683-11 F 7.6 10.5

Page 1034 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 18

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91683-12 F 7.2 9.9

 MALES MEAN 8.0 10.9

 FEMALES MEAN 7.5 10.3

 91685-01 M 8.3 10.9

 91685-02 M 8.4 11.8

 91685-03 M 8.6 11.6

 91685-04 M 8.3 11.2

 91685-05 M 8.9 11.5

 91685-06 F 8.3 11.4

 91685-07 F 7.6 10.1

 91685-08 F 8.5 NA

 91685-09 F 7.8 9.4

 91685-10 F 7.0 9.9

 MALES MEAN 8.5 11.4

 FEMALES MEAN 7.8 10.2

 MALES MEAN 7.9 10.2

 S.D. 0.60 0.87

 S.E. 0.17 0.25

 N 12 12

 FEMALES MEAN 7.3 9.5

 S.D. 0.74 0.88

 S.E. 0.22 0.25

 N 12 12

 NA = NOT APPLICABLE

Page 1035 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 19

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91620-02 M 7.5 10.0

 91620-03 M 7.2 9.8

 91620-04 M 7.5 10.7

 91620-05 M 7.1 8.9

 91620-06 M 7.8 10.3

 91620-07 M 7.8 10.4

 91620-08 M 7.7 10.0

 91620-09 M 8.2 10.5

 91620-10 F 7.0 8.8

 91620-11 F 6.6 9.2

 91620-12 F 6.3 8.3

 91620-13 F 7.2 9.7

 91620-14 F 6.9 8.8

 MALES MEAN 7.6 10.1

 FEMALES MEAN 6.8 9.0

 91628-02 F 8.0 9.7

 91628-03 M 7.9 10.3

 91628-04 M 7.7 9.5

 91628-05 M 8.2 10.1

 91628-06 M 8.2 9.8

 91628-07 M 7.4 9.9

 91628-08 M 7.1 8.4

 91628-09 M 7.6 9.8

 91628-10 F 7.0 9.2

Page 1036 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 20

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91628-11 F 7.4 9.3

 91628-12 F 7.2 9.6

 91628-13 F 7.7 9.2

 91628-14 F 7.8 9.2

 91628-15 F 7.5 9.7

 MALES MEAN 7.7 9.7

 FEMALES MEAN 7.5 9.4

 91631-01 M 7.2 NA

 91631-02 M 8.2 11.4

 91631-03 M 6.8 9.9

 91631-04 M 8.9 11.6

 91631-05 M 8.3 10.6

 91631-06 M 7.7 10.1

 91631-07 M 8.1 11.0

 91631-08 M 5.6 NA

 91631-09 M 7.6 10.0

 91631-10 F 7.2 9.3

 91631-11 F 7.7 9.6

 91631-12 F 8.1 10.5

 91631-13 F 7.2 9.4

 91631-14 F 6.9 9.1

 NA = NOT APPLICABLE

Page 1037 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 21

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91631-15 F 7.3 10.3

 MALES MEAN 7.6 10.7

 FEMALES MEAN 7.4 9.7

 91636-01 M 8.2 10.4

 91636-02 M 8.0 9.9

 91636-03 M 8.2 9.8

 91636-04 M 7.3 9.7

 91636-05 F 7.6 9.0

 91636-06 F 8.0 9.8

 91636-07 F 7.3 8.8

 91636-08 F 7.6 9.2

 91636-09 F 6.2 7.6

 91636-10 F 5.9 7.7

 91636-11 F 7.0 8.5

 91636-12 F 6.8 8.4

 91636-13 F 7.0 8.9

 MALES MEAN 7.9 10.0

 FEMALES MEAN 7.0 8.7

 91649-01 M 6.8 8.0

 91649-02 M 7.3 8.7

 91649-03 M 8.1 8.9

 91649-04 M 6.7 8.0

Page 1038 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 22

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91649-05 M 7.6 7.3

 91649-06 M 7.9 6.6

 91649-07 F 7.6 10.3

 91649-08 F 7.4 9.0

 91649-09 F 6.4 8.4

 91649-10 F 7.3 7.9

 91649-11 F 7.4 9.5

 91649-12 F 7.5 9.7

 91649-13 F 7.9 10.3

 91649-14 F 6.2 6.8

 91649-15 F 6.5 7.6

 91649-16 F 7.5 9.7

 MALES MEAN 7.4 7.9

 FEMALES MEAN 7.2 8.9

 91650-02 M 7.9 10.2

 91650-03 M 6.9 9.6

 91650-04 M 7.6 9.6

 91650-05 M 6.7 7.9

 91650-06 M 7.9 10.4

 91650-07 M 7.6 9.9

 91650-08 M 8.2 10.5

 91650-09 F 7.1 9.6

 91650-10 F 6.2 8.9

 91650-11 F 7.9 10.9

Page 1039 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 23

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91650-12 F 4.9 6.6

 91650-13 F 7.8 10.1

 91650-14 F 7.7 10.4

 MALES MEAN 7.5 9.7

 FEMALES MEAN 6.9 9.4

 91656-03 M 8.4 10.9

 91656-04 M 7.2 10.1

 91656-06 M 7.3 9.7

 91656-07 M 7.3 9.3

 91656-08 F 6.9 8.4

 91656-09 F 7.3 9.5

 91656-10 F 7.1 9.7

 91656-11 F 7.7 9.9

 91656-12 F 7.3 9.6

 91656-13 F 7.4 9.4

 91656-14 F 6.7 NA

 91656-15 F 7.1 9.7

 MALES MEAN 7.6 10.0

 FEMALES MEAN 7.2 9.5

 91671-03 M 7.0 9.8

 91671-04 M 7.6 10.8

 91671-05 M 7.7 8.7

 NA = NOT APPLICABLE

Page 1040 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 24

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91671-06 M 7.4 9.9

 91671-08 M 6.9 10.0

 91671-09 M 6.9 10.0

 91671-10 F 6.4 9.0

 91671-12 F 6.8 10.2

 91671-13 F 7.1 9.6

 91671-14 F 6.9 9.6

 91671-15 F 6.0 8.4

 MALES MEAN 7.3 9.9

 FEMALES MEAN 6.6 9.4

 91675-01 M 7.0 8.4

 91675-02 M 8.0 8.2

 91675-03 M 7.0 8.6

 91675-05 M 8.3 9.8

 91675-06 F 8.5 10.8

 91675-07 F 7.4 9.6

 91675-08 F 8.1 10.3

 91675-09 F 7.6 9.0

 91675-10 F 7.3 8.8

 91675-11 F 6.6 NA

 91675-12 F 7.3 9.6

 91675-13 F 8.0 9.6

 NA = NOT APPLICABLE

Page 1041 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 25

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91675-14 F 5.9 NA

 MALES MEAN 7.6 8.8

 FEMALES MEAN 7.4 9.7

 91677-01 M 8.3 NA

 91677-02 M 7.8 10.5

 91677-03 F 7.6 9.6

 91677-04 F 7.3 NA

 91677-05 F 8.1 9.8

 MALES MEAN 8.1 10.5

 FEMALES MEAN 7.7 9.7

 91679-03 M 7.8 10.6

 91679-04 M 8.3 11.4

 91679-05 M 8.7 10.7

 91679-06 M 6.9 NA

 91679-07 M 8.8 8.9

 91679-08 M 9.0 12.2

 91679-09 F 8.0 11.4

 91679-10 F 8.2 NA

 NA = NOT APPLICABLE

Page 1042 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 26

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91679-12 F 7.5 10.6

 MALES MEAN 8.3 10.8

 FEMALES MEAN 7.9 11.0

 91684-01 M 7.9 9.7

 91684-02 M 7.3 8.6

 91684-03 M 7.2 8.9

 91684-04 M 7.2 8.4

 91684-05 M 6.2 8.0

 91684-06 M 6.1 7.5

 91684-07 M 7.7 8.9

 91684-08 M 7.4 8.8

 91684-09 M 7.2 8.2

 91684-10 F 7.0 8.1

 91684-11 F 6.6 8.0

 91684-12 F 7.0 8.0

 91684-13 F 6.3 7.7

 91684-14 F 6.7 6.3

 91684-15 F 6.9 8.6

 91684-16 F 6.8 7.9

 MALES MEAN 7.1 8.6

 FEMALES MEAN 6.8 7.8

 MALES MEAN 7.6 9.7

 S.D. 0.33 0.88

 S.E. 0.10 0.25

 N 12 12

 FEMALES MEAN 7.2 9.4

 S.D. 0.40 0.75

 S.E. 0.11 0.22

 N 12 12

Page 1043 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 27

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 4: 175 PPM

---------------------------------------

 91622-04 M 7.1 8.6

 91622-05 M 7.0 8.1

 91622-06 M 6.6 8.0

 91622-07 M 6.7 7.7

 91622-08 M 6.9 NA

 91622-09 M 7.1 8.3

 91622-10 M 6.8 7.1

 91622-11 F 5.8 7.7

 91622-12 F 6.6 8.1

 91622-13 F 6.5 NA

 91622-14 F 6.1 NA

 MALES MEAN 6.9 8.0

 FEMALES MEAN 6.3 7.9

 91626-02 M 7.0 9.8

 91626-03 M 7.0 9.9

 91626-04 M 7.0 9.8

 91626-05 M 7.3 10.5

 91626-06 M 7.1 9.6

 91626-07 M 7.0 9.6

 91626-08 F 5.7 8.4

 91626-09 F 6.3 9.4

 91626-10 F 6.1 9.1

 91626-11 F 6.0 7.9

 91626-12 F 6.9 9.6

 NA = NOT APPLICABLE

Page 1044 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 28

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 4: 175 PPM

---------------------------------------

 91626-13 F 6.5 9.4

 91626-14 F 6.4 8.4

 MALES MEAN 7.1 9.9

 FEMALES MEAN 6.3 8.9

 91643-02 M 7.3 9.3

 91643-03 M 7.0 9.0

 91643-04 M 7.1 9.4

 91643-05 M 8.1 9.4

 91643-06 M 7.3 9.4

 91643-07 M 7.5 9.1

 91643-08 M 7.6 9.7

 91643-09 M 7.5 9.0

 91643-10 F 7.5 9.5

 91643-11 F 7.0 8.9

 91643-12 F 7.2 9.5

 MALES MEAN 7.4 9.3

 FEMALES MEAN 7.2 9.3

 91654-04 M 6.0 NA

 91654-05 M 6.9 NA

 91654-06 M 5.9 NA

 91654-07 M 6.8 NA

 91654-08 M 6.4 NA

 NA = NOT APPLICABLE

Page 1045 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 29

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 4: 175 PPM

---------------------------------------

 91654-09 M 6.4 NA

 91654-11 M 7.4 NA

 91654-12 M 5.9 NA

 91654-13 M 6.6 NA

 91654-14 F 6.6 NA

 91654-15 F 6.2 NA

 91654-16 F 6.3 NA

 91654-17 F 5.8 NA

 91654-18 F 5.8 NA

 MALES MEAN 6.5

 FEMALES MEAN 6.1

 91657-01 F 6.1 NA

 91657-02 M 6.8 NA

 91657-03 M 6.8 NA

 91657-04 M 7.7 9.1

 91657-05 M 6.9 8.4

 91657-06 M 7.6 9.0

 91657-07 M 7.2 NA

 91657-08 F 5.6 NA

 91657-09 F 7.0 9.0

 91657-10 F 6.4 8.0

 91657-11 F 7.3 9.3

 91657-12 F 7.4 9.0

 NA = NOT APPLICABLE

Page 1046 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 30

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 4: 175 PPM

---------------------------------------

 91657-13 F 6.9 8.3

 MALES MEAN 7.2 8.8

 FEMALES MEAN 6.7 8.7

 91662-03 M 8.3 11.4

 91662-04 M 8.0 11.2

 91662-05 M 6.9 9.6

 91662-06 M 8.0 11.1

 91662-07 F 6.6 NA

 91662-08 F 6.9 NA

 91662-09 F 8.7 12.3

 91662-10 F 7.7 9.9

 91662-11 F 7.7 10.5

 MALES MEAN 7.8 10.8

 FEMALES MEAN 7.5 10.9

 91666-02 M 7.6 11.8

 91666-03 M 7.5 10.7

 91666-04 M 8.1 10.9

 91666-05 M 8.4 12.2

 91666-06 M 7.6 11.6

 91666-07 M 7.1 10.4

 91666-08 M 8.1 11.4

 91666-09 F 8.1 10.6

 NA = NOT APPLICABLE

Page 1047 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 31

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 4: 175 PPM

---------------------------------------

 91666-10 F 7.0 10.1

 91666-11 F 7.3 9.7

 MALES MEAN 7.8 11.3

 FEMALES MEAN 7.5 10.1

 91676-01 M 9.8 12.8

 91676-02 M 8.7 11.9

 91676-03 M 7.7 10.5

 91676-04 M 8.1 11.4

 91676-05 M 8.5 11.0

 91676-06 F 8.9 12.0

 91676-07 F 7.4 10.4

 91676-08 F 9.3 11.8

 91676-09 F 9.2 12.2

 91676-11 F 7.7 11.1

 MALES MEAN 8.6 11.5

 FEMALES MEAN 8.5 11.5

 91678-01 M 7.7 11.4

 91678-02 M 6.7 9.6

 91678-03 M 6.8 9.1

 91678-04 M 6.4 9.4

 91678-05 F 5.8 NA

 91678-06 F 7.5 10.8

 NA = NOT APPLICABLE

Page 1048 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 32

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 4: 175 PPM

---------------------------------------

 91678-07 F 7.1 10.1

 91678-08 F 7.5 10.7

 91678-09 F 6.9 9.0

 91678-10 F 6.8 8.3

 91678-11 F 7.3 9.9

 91678-12 F 7.1 10.4

 91678-13 F 7.3 10.0

 91678-14 F 7.5 10.6

 MALES MEAN 6.9 9.9

 FEMALES MEAN 7.1 10.0

 91681-04 M 7.2 9.5

 91681-05 M 7.0 7.8

 91681-06 M 6.5 8.8

 91681-07 M 6.2 NA

 91681-09 M 7.5 9.9

 91681-10 M 7.0 9.4

 91681-11 F 5.7 5.2

 91681-12 F 7.2 10.1

 91681-13 F 6.3 7.7

 91681-14 F 6.5 8.3

 NA = NOT APPLICABLE

Page 1049 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 33

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 4: 175 PPM

---------------------------------------

 91681-15 F 7.2 10.0

 MALES MEAN 6.9 9.1

 FEMALES MEAN 6.6 8.3

 91682-02 F 6.6 NA

 91682-04 M 6.9 7.6

 91682-05 M 7.2 NA

 91682-06 M 7.8 9.9

 91682-07 M 7.0 NA

 91682-08 M 7.6 10.3

 91682-09 M 6.1 NA

 91682-10 M 7.5 NA

 91682-11 M 6.6 6.8

 91682-12 F 6.3 7.6

 91682-13 F 6.0 NA

 MALES MEAN 7.1 8.7

 FEMALES MEAN 6.3 7.6

 MALES MEAN 7.3 9.7

 S.D. 0.58 1.17

 S.E. 0.18 0.37

 N 11 10

 FEMALES MEAN 6.9 9.3

 S.D. 0.73 1.29

 S.E. 0.22 0.41

 N 11 10

 NA = NOT APPLICABLE

Page 1050 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 34

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91624-01 M 7.8 9.8

 91624-02 M 8.0 9.7

 91624-03 M 8.0 10.2

 91624-04 M 7.1 8.7

 91624-05 M 7.9 9.7

 91624-06 M 7.7 9.0

 91624-07 M 7.6 8.8

 91624-08 M 7.4 9.7

 91624-09 F 6.0 8.1

 91624-10 F 6.8 9.2

 91624-11 F 7.0 9.0

 91624-12 F 7.2 8.7

 91624-13 F 6.3 8.4

 MALES MEAN 7.7 9.5

 FEMALES MEAN 6.7 8.7

 91625-01 M 7.6 11.0

 91625-02 M 7.8 11.0

 91625-03 M 7.4 11.4

 91625-04 M 7.5 10.1

 91625-05 M 8.5 11.9

 91625-06 F 7.9 10.4

 91625-07 F 7.4 10.6

 91625-08 F 7.3 11.1

 91625-09 F 6.9 9.9

Page 1051 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 35

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91625-10 F 7.9 11.8

 91625-11 F 7.2 9.8

 91625-12 F 7.3 10.3

 91625-13 F 7.5 10.3

 91625-14 F 7.6 10.4

 MALES MEAN 7.8 11.1

 FEMALES MEAN 7.4 10.5

 91627-01 M 7.4 10.0

 91627-02 M 9.2 9.8

 91627-03 M 8.3 10.6

 91627-04 M 8.6 10.9

 91627-05 M 8.0 10.4

 91627-06 M 7.7 9.9

 91627-07 M 8.8 10.9

 91627-08 M 8.0 10.2

 91627-09 F 8.8 10.5

 91627-10 F 7.7 9.8

 91627-11 F 7.3 9.4

 91627-12 F 7.5 9.7

Page 1052 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 36

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91627-13 F 8.2 9.6

 MALES MEAN 8.3 10.3

 FEMALES MEAN 7.9 9.8

 91634-01 M 7.7 10.1

 91634-02 M 7.9 9.8

 91634-03 M 7.8 10.3

 91634-04 M 8.0 10.4

 91634-05 M 6.8 8.6

 91634-06 M 7.7 10.1

 91634-07 F 7.4 9.9

 91634-08 F 7.4 9.6

 91634-09 F 7.0 9.3

 91634-10 F 7.4 9.2

 91634-11 F 7.0 9.4

 91634-12 F 7.5 9.3

 91634-13 F 7.4 9.8

 MALES MEAN 7.7 9.9

 FEMALES MEAN 7.3 9.5

 91635-02 M 8.7 11.6

 91635-03 M 9.7 11.8

 91635-04 M 9.6 12.3

 91635-05 M 8.6 10.9

Page 1053 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 37

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91635-06 M 8.6 10.8

 91635-07 M 8.5 11.2

 91635-08 F 8.8 10.5

 91635-09 F 8.7 10.9

 91635-10 F 8.3 10.0

 91635-11 F 8.2 10.9

 91635-12 F 8.8 11.4

 91635-13 F 8.7 10.1

 MALES MEAN 9.0 11.4

 FEMALES MEAN 8.6 10.6

 91638-01 M 7.0 8.8

 91638-02 M 7.5 10.0

 91638-03 M 7.8 10.0

 91638-04 M 7.3 9.8

 91638-05 M 7.5 10.0

 91638-06 M 7.0 9.6

 91638-07 M 6.2 8.5

 91638-08 M 7.1 9.8

 91638-09 M 7.1 9.4

 91638-10 F 6.3 9.1

 91638-11 F 7.2 9.2

 91638-12 F 6.5 8.4

 91638-13 F 6.6 9.4

 91638-14 F 6.9 9.2

Page 1054 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 38

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91638-15 F 6.8 7.9

 91638-16 F 6.2 9.0

 MALES MEAN 7.2 9.5

 FEMALES MEAN 6.6 8.9

 91652-03 M 7.8 11.2

 91652-04 M 8.5 11.9

 91652-05 M 8.7 12.5

 91652-06 M 7.8 11.4

 91652-07 M 9.0 13.4

 91652-08 M 8.6 12.1

 91652-09 M 8.2 11.9

 91652-10 M 8.1 11.6

 91652-11 F 6.4 7.0

 91652-12 F 8.2 12.1

 91652-13 F 7.4 9.5

 MALES MEAN 8.3 12.0

 FEMALES MEAN 7.3 9.5

 91655-01 M 7.7 10.1

 91655-02 M 7.3 9.2

 91655-03 M 6.3 8.4

 91655-04 M 7.6 10.9

 91655-05 F 7.5 10.8

Page 1055 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 39

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91655-06 F 6.6 9.4

 91655-07 F 7.3 10.7

 91655-08 F 6.1 NA

 91655-09 F 7.4 10.5

 91655-10 F 6.3 9.4

 91655-11 F 7.0 10.2

 91655-12 F 5.8 8.2

 MALES MEAN 7.2 9.7

 FEMALES MEAN 6.8 9.9

 91658-01 M 8.2 9.9

 91658-02 M 7.5 8.8

 91658-03 M 8.0 10.6

 91658-04 M 7.6 9.6

 91658-05 M 7.5 10.0

 91658-06 M 7.7 8.4

 91658-07 M 8.2 10.7

 91658-08 M 7.7 8.9

 91658-09 F 7.1 9.1

 91658-10 F 7.6 9.0

 91658-11 F 7.0 9.3

 91658-12 F 7.0 8.5

 NA = NOT APPLICABLE

Page 1056 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 40

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91658-13 F 7.6 9.4

 MALES MEAN 7.8 9.6

 FEMALES MEAN 7.3 9.1

 91667-01 M 6.6 9.3

 91667-02 M 7.6 10.9

 91667-03 M 6.7 8.9

 91667-04 M 7.0 8.4

 91667-05 M 6.7 9.0

 91667-06 F 7.3 10.2

 91667-07 F 6.5 9.0

 91667-08 F 6.5 8.7

 91667-09 F 6.5 8.8

 91667-10 F 6.6 8.9

 91667-11 F 6.3 8.0

 91667-12 F 6.8 9.1

 91667-13 F 6.8 8.8

 91667-14 F 6.0 7.6

 91667-15 F 7.0 9.5

 91667-16 F 6.4 8.9

 MALES MEAN 6.9 9.3

 FEMALES MEAN 6.6 8.9

 91668-03 M 8.2 11.2

Page 1057 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 41

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91668-04 M 8.3 10.2

 91668-05 M 7.8 10.5

 91668-06 M 8.3 11.1

 91668-07 M 8.0 11.0

 91668-08 M 7.7 10.4

 91668-09 M 7.6 10.7

 91668-10 M 7.3 9.9

 91668-11 M 7.9 11.1

 91668-12 F 8.0 11.2

 91668-13 F 6.5 7.1

 91668-14 F 7.6 10.1

 91668-15 F 7.5 10.3

 MALES MEAN 7.9 10.7

 FEMALES MEAN 7.4 9.7

 91680-01 M 7.0 9.6

 91680-02 M 6.4 8.1

 91680-03 M 7.6 10.0

 91680-04 M 7.4 9.9

 91680-05 M 6.9 9.5

 91680-06 M 7.4 10.2

 91680-07 M 7.6 10.1

 91680-08 F 7.3 10.3

 91680-09 F 7.2 9.5

 91680-10 F 6.6 9.2

Page 1058 of 1107
 TABLE A55 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 42

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHTS [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91680-11 F 6.2 8.7

 91680-12 F 6.6 9.4

 91680-13 F 6.7 8.6

 91680-14 F 6.2 8.0

 91680-15 F 6.9 9.4

 MALES MEAN 7.2 9.6

 FEMALES MEAN 6.7 9.1

 MALES MEAN 7.8 10.2

 S.D. 0.59 0.88

 S.E. 0.17 0.26

 N 12 12

 FEMALES MEAN 7.2 9.5

 S.D. 0.60 0.62

 S.E. 0.17 0.18

 N 12 12

 PPWTNv4.21

 01/07/2014

 R:01/17/2014

Page 1059 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91629-01 M 1.6

 91629-02 M 1.7

 91629-03 M 2.0

 91629-04 M 1.4

 91629-05 M 1.6

 91629-06 M 2.1

 91629-08 M 1.4

 91629-09 M 1.8

 91629-10 M 1.7

 91629-11 M 1.7

 91629-12 M 1.9

 91629-13 F 1.8

 91629-14 F 1.9

 91629-15 F 1.3

 91629-16 F 1.9

 MALES MEAN 1.7

 FEMALES MEAN 1.7

 91630-03 M 3.6

 91630-04 M 3.5

 91630-05 M 3.1

 91630-06 M 3.2

 91630-07 M 3.3

 91630-08 M 3.4

 91630-09 F 3.0

Page 1060 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91630-10 F 3.1

 91630-11 F 3.2

 91630-12 F 2.9

 91630-13 F 3.4

 91630-14 F 2.7

 MALES MEAN 3.4

 FEMALES MEAN 3.1

 91633-01 M 1.5

 91633-02 M 2.3

 91633-03 M 2.1

 91633-04 M 1.3

 91633-05 M 1.4

 91633-06 M 1.8

 91633-07 M 1.0

 91633-08 F 2.0

 91633-09 F 1.0

 91633-10 F 2.5

 91633-11 F 2.0

 91633-12 F 2.0

 91633-13 F 0.7

 91633-14 F 1.9

Page 1061 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91633-15 F 1.6

 MALES MEAN 1.6

 FEMALES MEAN 1.7

 91637-01 M 2.4

 91637-02 M 2.3

 91637-03 M 1.8

 91637-04 M 2.5

 91637-06 F 2.8

 91637-07 F 2.4

 91637-08 F 2.4

 91637-09 F 2.7

 91637-10 F 1.7

 91637-11 F 2.8

 91637-12 F 2.6

 91637-13 F 2.5

 MALES MEAN 2.3

 FEMALES MEAN 2.5

 91639-02 M 3.6

 91639-03 M 3.7

 91639-04 M 3.6

 91639-05 M 4.1

 91639-06 M 2.8

Page 1062 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91639-07 M 3.7

 91639-08 M 2.8

 91639-09 F 3.1

 91639-10 F 2.9

 MALES MEAN 3.5

 FEMALES MEAN 3.0

 91644-01 M 1.7

 91644-02 M 1.6

 91644-03 M 1.7

 91644-04 M 0.7

 91644-05 M 1.5

 91644-06 M 1.2

 91644-07 M 1.8

 91644-08 M 1.4

 91644-09 M 1.3

 91644-10 M 1.2

 91644-11 F 1.3

 91644-12 F 1.1

 91644-13 F 1.0

 91644-14 F 1.4

 91644-15 F 1.2

 91644-16 F 1.2

 MALES MEAN 1.4

 FEMALES MEAN 1.2

Page 1063 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91645-01 M 2.9

 91645-02 M 2.8

 91645-03 M 3.0

 91645-04 M 3.2

 91645-05 M 3.8

 91645-06 M 2.9

 91645-07 M 3.1

 91645-09 M 3.6

 91645-10 F 3.2

 91645-11 F 2.2

 91645-12 F 3.0

 91645-13 F 3.1

 91645-14 F 3.1

 91645-15 F 2.9

 91645-16 F 3.5

 MALES MEAN 3.2

 FEMALES MEAN 3.0

 91648-02 M 3.5

 91648-03 M 3.6

 91648-04 M 3.8

 91648-05 M 3.7

 91648-06 M 3.4

 91648-07 M 3.3

 91648-08 M 4.2

Page 1064 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91648-09 M 3.6

 91648-10 F 3.4

 91648-11 F 3.0

 91648-12 F 3.7

 91648-13 F 3.5

 91648-14 F 3.8

 MALES MEAN 3.6

 FEMALES MEAN 3.5

 91653-01 M 1.9

 91653-02 M 3.1

 91653-03 M 1.2

 91653-04 M 2.7

 91653-05 M 2.4

 91653-06 M 2.1

 91653-07 F 2.0

 91653-08 F 2.4

 91653-09 F 2.3

 91653-10 F 1.3

 91653-11 F 2.7

 91653-12 F 1.8

 91653-13 F 2.0

 91653-14 F 2.4

Page 1065 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91653-15 F 1.4

 MALES MEAN 2.2

 FEMALES MEAN 2.0

 91660-02 M 3.4

 91660-03 M 3.6

 91660-04 M 3.0

 91660-05 M 3.9

 91660-06 M 3.8

 91660-07 M 3.4

 91660-08 M 3.8

 91660-09 M 3.6

 91660-10 F 3.0

 91660-11 F 2.8

 91660-12 F 2.6

 91660-13 F 3.1

 91660-14 F 3.0

 MALES MEAN 3.6

 FEMALES MEAN 2.9

 91670-01 M 1.8

 91670-02 M 2.1

 91670-03 M 2.3

 91670-04 M 2.2

Page 1066 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91670-05 M 2.7

 91670-06 M 2.3

 91670-07 M 2.2

 91670-08 M 2.1

 91670-09 F 2.3

 91670-10 F 2.8

 91670-11 F 1.2

 91670-12 F 2.0

 91670-13 F 2.6

 91670-14 F 1.9

 MALES MEAN 2.2

 FEMALES MEAN 2.1

 91672-02 M 3.5

 91672-03 M 3.4

 91672-04 M 4.2

 91672-05 M 2.0

 91672-06 M 4.8

 91672-08 M 4.4

 91672-09 F 4.8

 91672-10 F 4.2

 91672-12 F 3.5

 91672-13 F 4.1

Page 1067 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 9

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 1: 0 PPM

---------------------------------------

 91672-14 F 2.4

 MALES MEAN 3.7

 FEMALES MEAN 3.8

 MALES MEAN 2.7

 S.D. 0.88

 S.E. 0.25

 N 12

 FEMALES MEAN 2.5

 S.D. 0.80

 S.E. 0.23

 N 12

Page 1068 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 10

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91632-01 M 1.7

 91632-02 M 0.9

 91632-03 M 1.9

 91632-04 M 2.1

 91632-05 F 1.7

 91632-06 F 1.7

 91632-07 F 1.7

 91632-08 F 1.4

 91632-09 F 1.7

 91632-10 F 2.1

 91632-11 F 1.8

 91632-12 F 1.7

 91632-13 F 1.7

 91632-14 F 1.4

 MALES MEAN 1.7

 FEMALES MEAN 1.7

 91640-03 F 1.8

 91640-04 M 3.8

 91640-05 M 2.4

 91640-06 M 3.3

 91640-07 F 3.5

 91640-08 F 3.5

 91640-09 F 3.1

 91640-10 F 3.6

Page 1069 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 11

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91640-11 F 2.5

 91640-12 F 3.6

 MALES MEAN 3.2

 FEMALES MEAN 3.1

 91642-01 M 1.5

 91642-02 M 2.1

 91642-03 M 2.0

 91642-04 M 2.2

 91642-05 F 2.0

 91642-06 F 2.2

 91642-07 F 2.3

 91642-08 F 1.4

 91642-09 F 1.4

 91642-10 F 1.9

 91642-11 F 1.6

 91642-12 F 0.0

 91642-13 F 1.6

 91642-14 F 2.2

 91642-15 M 1.6

 MALES MEAN 1.9

 FEMALES MEAN 1.7

 91647-03 M 2.3

Page 1070 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 12

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91647-04 M 2.4

 91647-05 M 1.9

 91647-06 M 2.1

 91647-07 M 2.1

 91647-08 M 1.9

 91647-09 F 2.4

 91647-10 F 1.6

 91647-11 F 1.8

 91647-12 F 2.2

 91647-13 F 2.0

 MALES MEAN 2.1

 FEMALES MEAN 2.0

 91651-01 M 3.2

 91651-02 M 2.6

 91651-03 M 1.9

 91651-04 M 2.9

 91651-05 M 2.5

 91651-06 M 1.6

 91651-07 M 2.5

 91651-08 F 0.1

 91651-09 F 2.0

 91651-10 F 3.1

 91651-11 F 2.0

Page 1071 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 13

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91651-12 F 2.0

 MALES MEAN 2.5

 FEMALES MEAN 1.8

 91659-02 M 1.1

 91659-03 M 2.6

 91659-04 M 2.2

 91659-05 M 1.5

 91659-06 M 2.8

 91659-07 M 2.6

 91659-08 F 2.2

 91659-09 F 1.7

 91659-10 F 2.1

 91659-11 F 1.9

 91659-12 F 2.0

 91659-13 F 2.4

 MALES MEAN 2.1

 FEMALES MEAN 2.1

 91661-01 M 2.4

 91661-02 M 2.1

 91661-03 M 3.1

 91661-04 M 3.2

 91661-05 M 3.0

Page 1072 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 14

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91661-06 M 3.2

 91661-07 M 3.2

 91661-08 M 2.6

 91661-09 M 2.6

 91661-10 M 3.0

 91661-11 M 2.2

 91661-12 F 2.7

 91661-13 F 1.5

 91661-14 F 1.8

 91661-15 F 2.8

 91661-16 F 2.3

 91661-17 F 2.9

 MALES MEAN 2.8

 FEMALES MEAN 2.3

 91663-01 M 2.3

 91663-03 M 2.3

 91663-04 M 2.5

 91663-05 M 0.1

 91663-06 M 2.4

 91663-07 M 2.3

 91663-08 F 2.9

 91663-09 F 1.9

 91663-10 F 3.0

 91663-11 F 2.2

Page 1073 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 15

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91663-12 F 2.1

 91663-13 F 2.5

 91663-15 F 2.8

 MALES MEAN 2.0

 FEMALES MEAN 2.5

 91669-01 M 2.6

 91669-02 M 0.9

 91669-03 M 0.2

 91669-04 M 2.4

 91669-06 M 2.8

 91669-07 M 2.9

 91669-08 M 2.6

 91669-09 M 1.6

 91669-10 F 2.8

 91669-12 F 2.6

 91669-13 F 2.4

 91669-14 F 2.5

 MALES MEAN 2.0

 FEMALES MEAN 2.6

 91673-01 M 1.9

 91673-02 M 1.4

 91673-03 M 1.6

Page 1074 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 16

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91673-04 M 1.9

 91673-05 M 1.4

 91673-06 M 1.7

 91673-07 F 1.5

 91673-08 F 1.9

 91673-09 F 1.7

 91673-10 F 1.8

 91673-11 F 2.0

 91673-12 F 2.0

 91673-13 F 2.0

 91673-14 F 2.1

 91673-15 F 1.1

 91673-16 F 0.9

 MALES MEAN 1.7

 FEMALES MEAN 1.7

 91683-01 M 3.3

 91683-02 M 2.7

 91683-03 M 3.3

 91683-04 M 3.1

 91683-05 M 2.8

 91683-06 M 2.7

 91683-07 F 3.1

 91683-08 F 2.9

 91683-09 F 3.1

Page 1075 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 17

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 2: 50 PPM

---------------------------------------

 91683-10 F 2.4

 91683-11 F 2.9

 91683-12 F 2.7

 MALES MEAN 3.0

 FEMALES MEAN 2.9

 91685-01 M 2.6

 91685-02 M 3.4

 91685-03 M 3.0

 91685-04 M 2.9

 91685-05 M 2.6

 91685-06 F 3.1

 91685-07 F 2.5

 91685-09 F 1.6

 91685-10 F 2.9

 MALES MEAN 2.9

 FEMALES MEAN 2.5

 MALES MEAN 2.3

 S.D. 0.53

 S.E. 0.15

 N 12

 FEMALES MEAN 2.2

 S.D. 0.49

 S.E. 0.14

 N 12

Page 1076 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 18

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91620-02 M 2.5

 91620-03 M 2.6

 91620-04 M 3.2

 91620-05 M 1.8

 91620-06 M 2.5

 91620-07 M 2.6

 91620-08 M 2.3

 91620-09 M 2.3

 91620-10 F 1.8

 91620-11 F 2.6

 91620-12 F 2.0

 91620-13 F 2.5

 91620-14 F 1.9

 MALES MEAN 2.5

 FEMALES MEAN 2.2

 91628-02 F 1.7

 91628-03 M 2.4

 91628-04 M 1.8

 91628-05 M 1.9

 91628-06 M 1.6

 91628-07 M 2.5

 91628-08 M 1.3

 91628-09 M 2.2

 91628-10 F 2.2

Page 1077 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 19

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91628-11 F 1.9

 91628-12 F 2.4

 91628-13 F 1.5

 91628-14 F 1.4

 91628-15 F 2.2

 MALES MEAN 2.0

 FEMALES MEAN 1.9

 91631-02 M 3.2

 91631-03 M 3.1

 91631-04 M 2.7

 91631-05 M 2.3

 91631-06 M 2.4

 91631-07 M 2.9

 91631-09 M 2.4

 91631-10 F 2.1

 91631-11 F 1.9

 91631-12 F 2.4

 91631-13 F 2.2

 91631-14 F 2.2

Page 1078 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 20

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91631-15 F 3.0

 MALES MEAN 2.7

 FEMALES MEAN 2.3

 91636-01 M 2.2

 91636-02 M 1.9

 91636-03 M 1.6

 91636-04 M 2.4

 91636-05 F 1.4

 91636-06 F 1.8

 91636-07 F 1.5

 91636-08 F 1.6

 91636-09 F 1.4

 91636-10 F 1.8

 91636-11 F 1.5

 91636-12 F 1.6

 91636-13 F 1.9

 MALES MEAN 2.0

 FEMALES MEAN 1.6

 91649-01 M 1.2

 91649-02 M 1.4

 91649-03 M 0.8

 91649-04 M 1.3

Page 1079 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 21

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91649-05 M -0.3

 91649-06 M -1.3

 91649-07 F 2.7

 91649-08 F 1.6

 91649-09 F 2.0

 91649-10 F 0.6

 91649-11 F 2.1

 91649-12 F 2.2

 91649-13 F 2.4

 91649-14 F 0.6

 91649-15 F 1.1

 91649-16 F 2.2

 MALES MEAN 0.5

 FEMALES MEAN 1.8

 91650-02 M 2.3

 91650-03 M 2.7

 91650-04 M 2.0

 91650-05 M 1.2

 91650-06 M 2.5

 91650-07 M 2.3

 91650-08 M 2.3

 91650-09 F 2.5

 91650-10 F 2.7

 91650-11 F 3.0

Page 1080 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 22

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91650-12 F 1.7

 91650-13 F 2.3

 91650-14 F 2.7

 MALES MEAN 2.2

 FEMALES MEAN 2.5

 91656-03 M 2.5

 91656-04 M 2.9

 91656-06 M 2.4

 91656-07 M 2.0

 91656-08 F 1.5

 91656-09 F 2.2

 91656-10 F 2.6

 91656-11 F 2.2

 91656-12 F 2.3

 91656-13 F 2.0

 91656-15 F 2.6

 MALES MEAN 2.5

 FEMALES MEAN 2.2

 91671-03 M 2.8

 91671-04 M 3.2

 91671-05 M 1.0

 91671-06 M 2.5

Page 1081 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 23

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91671-08 M 3.1

 91671-09 M 3.1

 91671-10 F 2.6

 91671-12 F 3.4

 91671-13 F 2.5

 91671-14 F 2.7

 91671-15 F 2.4

 MALES MEAN 2.6

 FEMALES MEAN 2.7

 91675-01 M 1.4

 91675-02 M 0.2

 91675-03 M 1.6

 91675-05 M 1.5

 91675-06 F 2.3

 91675-07 F 2.2

 91675-08 F 2.2

 91675-09 F 1.4

 91675-10 F 1.5

 91675-12 F 2.3

 91675-13 F 1.6

 MALES MEAN 1.2

 FEMALES MEAN 1.9

Page 1082 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 24

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91677-02 M 2.7

 91677-03 F 2.0

 91677-05 F 1.7

 MALES MEAN 2.7

 FEMALES MEAN 1.9

 91679-03 M 2.8

 91679-04 M 3.1

 91679-05 M 2.0

 91679-07 M 0.1

 91679-08 M 3.2

 91679-09 F 3.4

 91679-12 F 3.1

 MALES MEAN 2.2

 FEMALES MEAN 3.3

 91684-01 M 1.8

 91684-02 M 1.3

 91684-03 M 1.7

 91684-04 M 1.2

 91684-05 M 1.8

 91684-06 M 1.4

 91684-07 M 1.2

 91684-08 M 1.4

Page 1083 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 25

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 3: 100 PPM

---------------------------------------

 91684-09 M 1.0

 91684-10 F 1.1

 91684-11 F 1.4

 91684-12 F 1.0

 91684-13 F 1.4

 91684-14 F -0.4

 91684-15 F 1.7

 91684-16 F 1.1

 MALES MEAN 1.4

 FEMALES MEAN 1.0

 MALES MEAN 2.0

 S.D. 0.68

 S.E. 0.20

 N 12

 FEMALES MEAN 2.1

 S.D. 0.58

 S.E. 0.17

 N 12

Page 1084 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 26

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 4: 175 PPM

---------------------------------------

 91622-04 M 1.5

 91622-05 M 1.1

 91622-06 M 1.4

 91622-07 M 1.0

 91622-09 M 1.2

 91622-10 M 0.3

 91622-11 F 1.9

 91622-12 F 1.5

 MALES MEAN 1.1

 FEMALES MEAN 1.7

 91626-02 M 2.8

 91626-03 M 2.9

 91626-04 M 2.8

 91626-05 M 3.2

 91626-06 M 2.5

 91626-07 M 2.6

 91626-08 F 2.7

 91626-09 F 3.1

 91626-10 F 3.0

 91626-11 F 1.9

 91626-12 F 2.7

 91626-13 F 2.9

Page 1085 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 27

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 4: 175 PPM

---------------------------------------

 91626-14 F 2.0

 MALES MEAN 2.8

 FEMALES MEAN 2.6

 91643-02 M 2.0

 91643-03 M 2.0

 91643-04 M 2.3

 91643-05 M 1.3

 91643-06 M 2.1

 91643-07 M 1.6

 91643-08 M 2.1

 91643-09 M 1.5

 91643-10 F 2.0

 91643-11 F 1.9

 91643-12 F 2.3

 MALES MEAN 1.9

 FEMALES MEAN 2.1

 91657-04 M 1.4

 91657-05 M 1.5

 91657-06 M 1.4

 91657-09 F 2.0

 91657-10 F 1.6

 91657-11 F 2.0

Page 1086 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 28

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 4: 175 PPM

---------------------------------------

 91657-12 F 1.6

 91657-13 F 1.4

 MALES MEAN 1.4

 FEMALES MEAN 1.7

 91662-03 M 3.1

 91662-04 M 3.2

 91662-05 M 2.7

 91662-06 M 3.1

 91662-09 F 3.6

 91662-10 F 2.2

 91662-11 F 2.8

 MALES MEAN 3.0

 FEMALES MEAN 2.9

 91666-02 M 4.2

 91666-03 M 3.2

 91666-04 M 2.8

 91666-05 M 3.8

 91666-06 M 4.0

 91666-07 M 3.3

 91666-08 M 3.3

 91666-09 F 2.5

 91666-10 F 3.1

Page 1087 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 29

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 4: 175 PPM

---------------------------------------

 91666-11 F 2.4

 MALES MEAN 3.5

 FEMALES MEAN 2.7

 91676-01 M 3.0

 91676-02 M 3.2

 91676-03 M 2.8

 91676-04 M 3.3

 91676-05 M 2.5

 91676-06 F 3.1

 91676-07 F 3.0

 91676-08 F 2.5

 91676-09 F 3.0

 91676-11 F 3.4

 MALES MEAN 3.0

 FEMALES MEAN 3.0

 91678-01 M 3.7

 91678-02 M 2.9

 91678-03 M 2.3

 91678-04 M 3.0

 91678-06 F 3.3

 91678-07 F 3.0

 91678-08 F 3.2

Page 1088 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 30

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 4: 175 PPM

---------------------------------------

 91678-09 F 2.1

 91678-10 F 1.5

 91678-11 F 2.6

 91678-12 F 3.3

 91678-13 F 2.7

 91678-14 F 3.1

 MALES MEAN 3.0

 FEMALES MEAN 2.8

 91681-04 M 2.3

 91681-05 M 0.8

 91681-06 M 2.3

 91681-09 M 2.4

 91681-10 M 2.4

 91681-11 F -0.5

 91681-12 F 2.9

 91681-13 F 1.4

 91681-14 F 1.8

 91681-15 F 2.8

 MALES MEAN 2.0

 FEMALES MEAN 1.7

 91682-04 M 0.7

 91682-06 M 2.1

Page 1089 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 31

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 4: 175 PPM

---------------------------------------

 91682-08 M 2.7

 91682-11 M 0.2

 91682-12 F 1.3

 MALES MEAN 1.4

 FEMALES MEAN 1.3

 MALES MEAN 2.3

 S.D. 0.85

 S.E. 0.27

 N 10

 FEMALES MEAN 2.3

 S.D. 0.62

 S.E. 0.20

 N 10

Page 1090 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 32

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91624-01 M 2.0

 91624-02 M 1.7

 91624-03 M 2.2

 91624-04 M 1.6

 91624-05 M 1.8

 91624-06 M 1.3

 91624-07 M 1.2

 91624-08 M 2.3

 91624-09 F 2.1

 91624-10 F 2.4

 91624-11 F 2.0

 91624-12 F 1.5

 91624-13 F 2.1

 MALES MEAN 1.8

 FEMALES MEAN 2.0

 91625-01 M 3.4

 91625-02 M 3.2

 91625-03 M 4.0

 91625-04 M 2.6

 91625-05 M 3.4

 91625-06 F 2.5

 91625-07 F 3.2

 91625-08 F 3.8

 91625-09 F 3.0

Page 1091 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 33

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91625-10 F 3.9

 91625-11 F 2.6

 91625-12 F 3.0

 91625-13 F 2.8

 91625-14 F 2.8

 MALES MEAN 3.3

 FEMALES MEAN 3.1

 91627-01 M 2.6

 91627-02 M 0.6

 91627-03 M 2.3

 91627-04 M 2.3

 91627-05 M 2.4

 91627-06 M 2.2

 91627-07 M 2.1

 91627-08 M 2.2

 91627-09 F 1.7

 91627-10 F 2.1

 91627-11 F 2.1

 91627-12 F 2.2

Page 1092 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 34

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91627-13 F 1.4

 MALES MEAN 2.1

 FEMALES MEAN 1.9

 91634-01 M 2.4

 91634-02 M 1.9

 91634-03 M 2.5

 91634-04 M 2.4

 91634-05 M 1.8

 91634-06 M 2.4

 91634-07 F 2.5

 91634-08 F 2.2

 91634-09 F 2.3

 91634-10 F 1.8

 91634-11 F 2.4

 91634-12 F 1.8

 91634-13 F 2.4

 MALES MEAN 2.2

 FEMALES MEAN 2.2

 91635-02 M 2.9

 91635-03 M 2.1

 91635-04 M 2.7

 91635-05 M 2.3

Page 1093 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 35

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91635-06 M 2.2

 91635-07 M 2.7

 91635-08 F 1.7

 91635-09 F 2.2

 91635-10 F 1.7

 91635-11 F 2.7

 91635-12 F 2.6

 91635-13 F 1.4

 MALES MEAN 2.5

 FEMALES MEAN 2.1

 91638-01 M 1.8

 91638-02 M 2.5

 91638-03 M 2.2

 91638-04 M 2.5

 91638-05 M 2.5

 91638-06 M 2.6

 91638-07 M 2.3

 91638-08 M 2.7

 91638-09 M 2.3

 91638-10 F 2.8

 91638-11 F 2.0

 91638-12 F 1.9

 91638-13 F 2.8

 91638-14 F 2.3

Page 1094 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 36

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91638-15 F 1.1

 91638-16 F 2.8

 MALES MEAN 2.4

 FEMALES MEAN 2.2

 91652-03 M 3.4

 91652-04 M 3.4

 91652-05 M 3.8

 91652-06 M 3.6

 91652-07 M 4.4

 91652-08 M 3.5

 91652-09 M 3.7

 91652-10 M 3.5

 91652-11 F 0.6

 91652-12 F 3.9

 91652-13 F 2.1

 MALES MEAN 3.7

 FEMALES MEAN 2.2

 91655-01 M 2.4

 91655-02 M 1.9

 91655-03 M 2.1

 91655-04 M 3.3

 91655-05 F 3.3

Page 1095 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 37

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91655-06 F 2.8

 91655-07 F 3.4

 91655-09 F 3.1

 91655-10 F 3.1

 91655-11 F 3.2

 91655-12 F 2.4

 MALES MEAN 2.4

 FEMALES MEAN 3.0

 91658-01 M 1.7

 91658-02 M 1.3

 91658-03 M 2.6

 91658-04 M 2.0

 91658-05 M 2.5

 91658-06 M 0.7

 91658-07 M 2.5

 91658-08 M 1.2

 91658-09 F 2.0

 91658-10 F 1.4

 91658-11 F 2.3

 91658-12 F 1.5

Page 1096 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 38

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91658-13 F 1.8

 MALES MEAN 1.8

 FEMALES MEAN 1.8

 91667-01 M 2.7

 91667-02 M 3.3

 91667-03 M 2.2

 91667-04 M 1.4

 91667-05 M 2.3

 91667-06 F 2.9

 91667-07 F 2.5

 91667-08 F 2.2

 91667-09 F 2.3

 91667-10 F 2.3

 91667-11 F 1.7

 91667-12 F 2.3

 91667-13 F 2.0

 91667-14 F 1.6

 91667-15 F 2.5

 91667-16 F 2.5

 MALES MEAN 2.4

 FEMALES MEAN 2.3

 91668-03 M 3.0

Page 1097 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 39

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91668-04 M 1.9

 91668-05 M 2.7

 91668-06 M 2.8

 91668-07 M 3.0

 91668-08 M 2.7

 91668-09 M 3.1

 91668-10 M 2.6

 91668-11 M 3.2

 91668-12 F 3.2

 91668-13 F 0.6

 91668-14 F 2.5

 91668-15 F 2.8

 MALES MEAN 2.8

 FEMALES MEAN 2.3

 91680-01 M 2.6

 91680-02 M 1.7

 91680-03 M 2.4

 91680-04 M 2.5

 91680-05 M 2.6

 91680-06 M 2.8

 91680-07 M 2.5

 91680-08 F 3.0

 91680-09 F 2.3

 91680-10 F 2.6

Page 1098 of 1107
 TABLE A56 (F1)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 40

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]

-----------------------------------------------------------------------------------------------------------------------------------

 POSTNATAL DAY

 PUP NUMBER SEX 1- 4

-----------------------------------------------------------------------------------------------------------------------------------

 DAMS FROM GROUP 5: 10000 PPM

---------------------------------------

 91680-11 F 2.5

 91680-12 F 2.8

 91680-13 F 1.9

 91680-14 F 1.8

 91680-15 F 2.5

 MALES MEAN 2.4

 FEMALES MEAN 2.4

 MALES MEAN 2.5

 S.D. 0.56

 S.E. 0.16

 N 12

 FEMALES MEAN 2.3

 S.D. 0.39

 S.E. 0.11

 N 12

 PPWTNv4.21

 01/07/2014

 R:01/17/2014

Page 1099 of 1107
 TABLE A57 (F1 - UNSCHEDULED DEATHS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 1

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP NECROPSY FINDINGS

 FOUND DEAD OR EUTHANIZED MORIBUND OR IN EXTREMIS

-----------------------------------------------------------------------------------------------------------------------------------

 PUP LACT GROUP 1: 0 PPM

 NO. SEX DAY TISSUE FINDING GRADE

-----------------------------------------------------------------------------------------------------------------------------------

 91629 7 M 2 NO REMARKABLE OBSERVATIONS

 91630 1 M 0 GENERAL COMMENT CANNIBALIZED P

 MALFORMATION CONJOINED TWIN P

 2 M 0 STOMACH MILK NOT PRESENT P

 91637 5 M 3 NO REMARKABLE OBSERVATIONS

 91639 1 M 1 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P

 ABDOMINAL AND URINARY/REPRODUCTIVE

 91645 8-A M 0 STOMACH MILK PRESENT P

 91648 1 M 0 STOMACH MILK NOT PRESENT P

 91660 1 M 0 STOMACH MILK NOT PRESENT P

 91672 1 F 0 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P

 ABDOMINAL AND URINARY/REPRODUCTIVE

 7 M 4 NO REMARKABLE OBSERVATIONS

 11 F 2 NO REMARKABLE OBSERVATIONS

GRADE CODE: 1 - SLIGHT, 2 - MODERATE, 3 - MARKED, P - PRESENT

A = PUP FOUND DEAD ON PND 0, BUT HAD MILK PRESENT IN STOMACH; PUP CONSIDERED BORN ALIVE

Page 1100 of 1107
 TABLE A57 (F1 - UNSCHEDULED DEATHS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 2

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP NECROPSY FINDINGS

 FOUND DEAD OR EUTHANIZED MORIBUND OR IN EXTREMIS

-----------------------------------------------------------------------------------------------------------------------------------

 PUP LACT GROUP 2: 50 PPM

 NO. SEX DAY TISSUE FINDING GRADE

-----------------------------------------------------------------------------------------------------------------------------------

 91632 15 F 2 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P

 ABDOMINAL AND URINARY/REPRODUCTIVE

 91640 1 M 0 STOMACH MILK NOT PRESENT P

 2 M 0 STOMACH MILK NOT PRESENT P

 91647 1 F 0 STOMACH MILK NOT PRESENT P

 91659 1 M 1 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P

 ABDOMINAL AND URINARY/REPRODUCTIVE

 91663 2 M 1 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P

 ABDOMINAL AND URINARY/REPRODUCTIVE

 14 F 4 NO REMARKABLE OBSERVATIONS

 91669 5 M 4 NO REMARKABLE OBSERVATIONS

 11 F 4 NO REMARKABLE OBSERVATIONS

 15 F 4 NO REMARKABLE OBSERVATIONS

 16 F 3 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P

 THORACIC, ABDOMINAL AND URINARY/REPRODUCTIVE

GRADE CODE: 1 - SLIGHT, 2 - MODERATE, 3 - MARKED, P - PRESENT

Page 1101 of 1107
 TABLE A57 (F1 - UNSCHEDULED DEATHS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 3

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP NECROPSY FINDINGS

 FOUND DEAD OR EUTHANIZED MORIBUND OR IN EXTREMIS

-----------------------------------------------------------------------------------------------------------------------------------

 PUP LACT GROUP 3: 100 PPM

 NO. SEX DAY TISSUE FINDING GRADE

-----------------------------------------------------------------------------------------------------------------------------------

 91620 1 M 0 STOMACH MILK NOT PRESENT P

 91628 1 M 0 STOMACH MILK NOT PRESENT P

 91631 1 M 3 NO REMARKABLE OBSERVATIONS

 8 M 2 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P

 ABDOMINAL AND URINARY/REPRODUCTIVE

 MALFORMATION INTERVENTRICULAR SEPTAL DEFECT P

 A 1 MM IN DIAMETER OPENING IN THE ANTERIOR PORTION OF THE

 SEPTUM

 91650 1 M 0 STOMACH MILK NOT PRESENT P

 91656 1 F 0 STOMACH MILK NOT PRESENT P

 91671 1 M 0 STOMACH MILK NOT PRESENT P

 2 F 0 STOMACH MILK NOT PRESENT P

 11 F 1 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P

 ABDOMINAL AND URINARY/REPRODUCTIVE

 91675 4 M 1 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P

 ABDOMINAL AND URINIARY/REPRODUCTIVE

 11 F 4 NO REMARKABLE OBSERVATIONS

 91677 1 M 3 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P

 ABDOMINAL AND URINARY/REPRODUCTIVE

 91679 1 M 0 STOMACH MILK NOT PRESENT P

 2 F 0 STOMACH MILK NOT PRESENT P

 10 F 2 NO REMARKABLE OBSERVATIONS

GRADE CODE: 1 - SLIGHT, 2 - MODERATE, 3 - MARKED, P - PRESENT

Page 1102 of 1107
 TABLE A57 (F1 - UNSCHEDULED DEATHS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 4

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP NECROPSY FINDINGS

 FOUND DEAD OR EUTHANIZED MORIBUND OR IN EXTREMIS

-----------------------------------------------------------------------------------------------------------------------------------

 PUP LACT GROUP 3: 100 PPM

 NO. SEX DAY TISSUE FINDING GRADE

-----------------------------------------------------------------------------------------------------------------------------------

 91679 (CONTINUED)

 11 F 1 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P

 ABDOMINAL AND URINARY/REPRODUCTIVE

GRADE CODE: 1 - SLIGHT, 2 - MODERATE, 3 - MARKED, P - PRESENT

Page 1103 of 1107
 TABLE A57 (F1 - UNSCHEDULED DEATHS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 5

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP NECROPSY FINDINGS

 FOUND DEAD OR EUTHANIZED MORIBUND OR IN EXTREMIS

-----------------------------------------------------------------------------------------------------------------------------------

 PUP LACT GROUP 4: 175 PPM

 NO. SEX DAY TISSUE FINDING GRADE

-----------------------------------------------------------------------------------------------------------------------------------

 91622 1 M 1 STOMACH MILK NOT PRESENT P

 VARIATION THORACIC CAVITY- CONTENTS, DARK RED P

 2 M 1 STOMACH MILK NOT PRESENT P

 3 F 1 STOMACH MILK NOT PRESENT P

 8 M 2 NO REMARKABLE OBSERVATIONS

 13 F 2 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P

 ABDOMINAL AND URINIARY/REPRODUCTIVE

 14 F 3 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P

 ABDOMINAL AND URINARY/REPRODUCTIVE

 91626 1 F 1 STOMACH MILK NOT PRESENT P

 91643 1 M 1 STOMACH MILK NOT PRESENT P

 91654 1 F 0 GENERAL COMMENT CANNIBALIZED P

 2 M 0 STOMACH MILK NOT PRESENT P

 3 M 1 STOMACH MILK NOT PRESENT P

 4 M 2 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P

 THORACIC, ABDOMINAL AND URINARY/REPRODUCTIVE

 5 M 2 MALFORMATION INTERVENTRICULAR SEPTAL DEFECT P

 A 1 MM IN DIAMETER OPENING IN THE ANTERIOR PORTION OF THE

 SEPTUM

 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P

 ABDOMINAL AND URINARY/REPRODUCTIVE

 7 M 2 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P

 ABDOMINAL AND URINARY/REPRODUCTIVE

 MALFORMATION INTERVENTRICULAR SEPTAL DEFECT P

 A 2 MM IN DIAMETER OPENING IN THE ANTERIOR PORTION OF THE

 SEPTUM

 8 M 2 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P

GRADE CODE: 1 - SLIGHT, 2 - MODERATE, 3 - MARKED, P - PRESENT

Page 1104 of 1107
 TABLE A57 (F1 - UNSCHEDULED DEATHS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 6

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP NECROPSY FINDINGS

 FOUND DEAD OR EUTHANIZED MORIBUND OR IN EXTREMIS

-----------------------------------------------------------------------------------------------------------------------------------

 PUP LACT GROUP 4: 175 PPM

 NO. SEX DAY TISSUE FINDING GRADE

-----------------------------------------------------------------------------------------------------------------------------------

 91654 (CONTINUED)

 ABDOMINAL AND URINARY/REPRODUCTIVE

 8 M 2 MALFORMATION INTERVENTRICULAR SEPTAL DEFECT P

 A 1 MM IN DIAMETER OPENING IN THE ANTERIOR PORTION OF THE

 SEPTUM

 9 M 2 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P

 CRANIAL, THORACIC, ABDOMINAL AND URINARY/REPRODUCTIVE

 10 M 1 STOMACH MILK NOT PRESENT P

 12 M 2 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P

 ABDOMINAL AND URINARY/REPRODUCTIVE

 MALFORMATION INTERVENTRICULAR SEPTAL DEFECT P

 A 1 MM IN DIAMETER OPENING IN THE ANTERIOR PORTION OF THE

 SEPTUM

 14 F 2 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P

 ABDOMINAL AND URINARY/REPRODUCTIVE

 17 F 2 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P

 ABDOMINAL AND URINARY/REPRODUCTIVE

 91657 1 F 2 NO REMARKABLE OBSERVATIONS

 2 M 2 NO REMARKABLE OBSERVATIONS

 3 M 2 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P

 ABDOMINAL AND URINARY/REPRODUCTIVE

 7 M 2 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P

 ABDOMINAL AND URINARY/REPRODUCTIVE

 8 F 2 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P

 ABDOMINAL AND URINARY/REPRODUCTIVE

 91662 1 M 0 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P

 ABDOMINAL AND URINARY/REPRODUCTIVE

 2-A F 0 STOMACH MILK PRESENT P

GRADE CODE: 1 - SLIGHT, 2 - MODERATE, 3 - MARKED, P - PRESENT

A = PUP FOUND DEAD ON PND 0, BUT HAD MILK IN STOMACH; PUP CONSIDERED BORN ALIVE

Page 1105 of 1107
 TABLE A57 (F1 - UNSCHEDULED DEATHS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 7

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP NECROPSY FINDINGS

 FOUND DEAD OR EUTHANIZED MORIBUND OR IN EXTREMIS

-----------------------------------------------------------------------------------------------------------------------------------

 PUP LACT GROUP 4: 175 PPM

 NO. SEX DAY TISSUE FINDING GRADE

-----------------------------------------------------------------------------------------------------------------------------------

 91666 1 F 1 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P

 ABDOMINAL AND URINIARY/REPRODUCTIVE

 91678 5 F 4 NO REMARKABLE OBSERVATIONS

 91681 1 F 0 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P

 ABDOMINAL AND URINARY/REPRODUCTIVE

 2 F 0 STOMACH MILK NOT PRESENT P

 8 M 1 STOMACH MILK PRESENT P

 MALFORMATION INTERVENTRICULAR SEPTAL DEFECT P

 A 1 MM IN DIAMETER OPENING IN THE ANTERIOR PORTION OF THE

 SEPTUM

 91682 1 F 0 STOMACH MILK NOT PRESENT P

 VARIATION MAJOR BLOOD VESSEL VARIATION P

 RETROESOPHAGEAL RIGHT SUBCLAVIAN: RIGHT SUBCLAVIAN COURSES

 RETROESOPHAGEAL AND JOINS AORTIC ARCH ADJACENT TO DUCTUS

 ARTERIOSUS (NO BRACHIOCEPHALIC TRUNK)

 MALFORMATION VERTEBRAL AGENESIS P

 ANURY; SKELETAL RESULTS: ALL VERTEBRAE POSTERIOR TO THORACIC

 VERTEBRA #9 ABSENT, THORACIC CENTRUM #9 ABSENT; RIGHT RIB

 #10 WITH NO ARTICULATING HEAD; STERNOSCHISIS, STERNAL BANDS

 NOT JOINED, #3 THROUGH #6; COSTAL CARTILAGE ANOMALY, RIGHT

 COSTAL CARTILAGE #1 FUSED TO COSTAL CARTILAGE ARISING FROM

 7TH CERVICAL RIB AND ASSOCIATES WITH STERNUM IN NORMAL #1

 POSITION, ALL SUBSEQUENT RIGHT COSTAL CARTILAGES NOT

 AFFECTED; 7TH CERVICAL RIBS, FULL, RIGHT, INTERMEDIATE, LEFT

 MALFORMATION ANAL ATRESIA P

 MALFORMATION KIDNEY(S)- FUSED P

 MEDIAL AND MORE LATERALLY TRANSPOSED THAN NORMAL

GRADE CODE: 1 - SLIGHT, 2 - MODERATE, 3 - MARKED, P - PRESENT

Page 1106 of 1107
 TABLE A57 (F1 - UNSCHEDULED DEATHS)

PROJECT NO.:WIL-65501F RAT INHAL REPRO/ DEV/TOX STUDY OF 2-BROM-3,3,3-TRIFLUOROPROPENE PAGE 8

SPONSOR:AMERICAN PACIFIC CORP. INDIVIDUAL PUP NECROPSY FINDINGS

 FOUND DEAD OR EUTHANIZED MORIBUND OR IN EXTREMIS

-----------------------------------------------------------------------------------------------------------------------------------

 PUP LACT GROUP 5: 10000 PPM

 NO. SEX DAY TISSUE FINDING GRADE

-----------------------------------------------------------------------------------------------------------------------------------

 91635 1 M 0 STOMACH MILK NOT PRESENT P

 91652 1 M 0 STOMACH MILK NOT PRESENT P

 2 U 0 GENERAL COMMENT CANNIBALIZED P

 91655 8 F 2 NO REMARKABLE OBSERVATIONS

 13 F 1 GENERAL COMMENT TOO AUTOLYZED TO EXAMINE P

 ABDOMINAL AND URINARY/REPRODUCTIVE

 91668 1 U 0 GENERAL COMMENT CANNIBALIZED P

 2 M 0 STOMACH MILK NOT PRESENT P

GRADE CODE: 1 - SLIGHT, 2 - MODERATE, 3 - MARKED, P - PRESENT

 PPNRDv4.24

 02/24/2014

 R:02/24/2014

Page 1107 of 1107