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# PreManufacture Notice and

Notice of Commencement Forms EPA . Form7710-25 (Rev. 5-95) EPA Form7710-56 (Rev. -96)



# Installation and Use Instructions MS Word 6

. Ofor Windows

U .S. EPAApproved December 12,1996 by Anthony Cheatham 

## TSCA Data Administration Section © 'COMPI~I :~EVC .ASSIST,~ ~CE T () O L S 

# `~~ ResponsibleCare" 1 A Pubric CannMnent

### reg-e-dancTConfidentia

For Internal Review

Only January 4, 2008 Subject Handling Audience FTA Customers Purpose: %9 e product stewardship and safe handling information km based on N10SH guidance and the OSHA Hazcom standard. Planned usage a foreseeable/potential exposure scenarios are considered. Potential hazards and exposure scenarios, as well as hea 

### and recommended practices, a r worke personnel that could come in con nd safety precautions pervisors, and other 

## o ~I A xpertise in de ch y un er ie core princip industry's Responsible Card* Global Ch our products are handled safely and with 

### and handling the chemical ensure that ry stage of the RMdM& life cycle. As part of 

### a ram for



### arej=AIra ft Safe Ha research a information Is available kno 

### roduct stewardship nd ongoing product

abiifty mak ideal additives f ,y.r.ti : 

### or itional produ a echnica! information, n o nsert iirip 

### P

# UBLI C

: J . . . 

# COnr 1 HAZARD INFO" '"

,, "N 

### Before handling ant s

;111111 far to the product Materlal Safety Data Sheet (MSDS) for safe ha ng recommendations such as exposure control, PPE, spill clean up, and disposal, as well as toxicological and ecotoxicological data. P _

re stab low dust 

### pofentlal, and hazardou$ po e n no occur. During fire or extreme heat conditions, hazardous decomposition products could be released such as carbon uct data a mTa on;p. 30 afe Handling Guidelines eg and Confidential Information For Internal Review

Only January 4, 2008 W actlve fety rese ~ponsored b and Y 

### Research ' :

. roject is focused on researching inorgan Wtshino hazard and exposure assessmentlMs and characteri information e project also features planned Implementation of a public resea

'~re used exclusively as

also 

### ders ng of n 'MW- studies performed u 

### effects, Sensitization and mutage 

## DUNG itibiliiy testing. 

### vance the soyst("Ps. Toxicity 

### acute oral, dermal, or eye so been negative. are not available to co ditives in polymer a there . 

### handling products and use, mated systems,

:?;~.ya 

### ExilbiAire Control r consumer contact from to investiga workplace ere



### ready r9duceT"ikpo-s-u-re-p-5!5Fn Where N . . possibility extits for geherating dust or liquid aerosols into the air, control techniquiii,. ~uch as sourti"11 enclosure (i .e., isolating the generation source fromthe worker) antf:; i well~cies~hed exhaust ventilation system 

### particulate air (Tyf~PA~.~~ should effectively remove any airbom

### Safe Handling Guidelines

riviieged and Confidential Information For Internal Review

Only January 4, 2008 Work areas should be cleaned at the end of each shift (at a minimum), using either a HEPA-flltered vacuumcleaner or wet wiping methods. Dry sweeping or air hoses should not be used to clean work areas. Cleanup should be conducted in a manner that prevents contact with wastes; the disposal of all waste material should comply with all applicable Federal and State, and local regulations.



### consumption of food or beverages should be prevented wh re handled. In addition, hand-washing facilities should be provk3"dand workers Instructed to use them before eating, smoking, or leaving theworicsite. Where contact ' possible, facilities, changing clothes shou e eU o prevent the ina other areas (including take-home) caused by the tra clothing and skin. Persona! Protective Equipment 

### Permeation resistant gloves (butyl or nit protection. In addition, disposable cove contamination Is possible. At a minimum, a NIO41ji ft ed, fulf P 

### -pu elation potential exists while handling with water. If eye Irritation develops or

In addition to the usual medical history, the attending physician may find the following exposure information useful : date and time, duration, circumstances, concentration, body area exposed/affected, performed first aid measures.p. 32

1111l,Safe Handling Guidelines Privileged and Confidential Information For internal Review

Only January 4, 2008

, R w w~~ONTACT -INFORMATION For further information and assistance with understand 

### contact t For transportation emergencies, call CHEMTRECat 800-4249300 . For other emergencies, call th ur emergency number DISCLAIMER REFERENCES ' The Responsible CarOGlobal Charter: AWorldwide Arnerican Chemistry CouncY. i1 " . li1w =.ll =11 .N= l .hl .=ift F 1y- .c' 11/a

### Measuring body for hazardous substances*) Of

# UBLIC COPYp. 35

Ode: 2008-01-17 NO : 3 Col'IteAb 1 Reason for and scope of the exercise . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . 4 2 fdentificafion of hazardous substances. .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . 4 3 Description of the workinp am . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . 4 4 Nature of ft plant and resources used. . . . . . .. . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. .. . . . . . 5 5 Description of the process . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . .. . . . . .. . . .. . . . . .. . . . . . . . .. . . . . . . . 5 8 Technical protective measurea .. . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . .. . .. . .. . . . . . . . . . . . . . . . . . .. . . . 5 7 Measuring method. . . . . . . . . . . . . . . . .. .. . . . . . . . . . . .. . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . .. . . . . . . .. . . . . . . . . .. . . . . .. 5 8 Sampling conditions . .. . . . . . . . . . . .. .. . . . . . . . . . . .. . . . . . . . . . .. . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 9 Analytical method . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . .8 10 Test reaults: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . .. . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . 7 11 Evaluation, findings, measures to be taken. . . . . . . . . . . .. . . .. . . .. .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . 7 Appendix . . . . .. . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. .. . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . 8p. 36

- cda : 2008-01-17 Pop : 4
1 Reason for and scope of the exercise To determine the ooncentratiorn when conducting experiments

. , ) R 12, R 87 Dust (inhatable) 10 Dust rable 3 

# 9

? Explanation: 

# l~~l~ COP

R-PAraw R12 _ Re cam "fine" snd ~aln~u 

# I 3 DowAp*m

of #W world 

### oEated on the ground floor of

a whole the air exchange rate is 20000 n?/h. The laboratory measures approximately 3 .5 x 5 m with a height of approx. 3.2 m . The free-standing fume hood measures approx. 4x 1 m and is approx. 2.5 m high. The tedmc;ai area is ' normai fume hoods and with walk-in free-

me fume hoods. carried out in the free-standing fume hood, which slims an air rate of 2000 m'Ih. An air exchange rate of approx 5000 m'Ih is specified for the bench row, while for the laboratory as

y7~Doe: 2008-01-17 Pop: 5 One member of staff is responsible far the test. In total there are 4 members of staff in the technical service laboratory. .ed in a discontinuous to the heated reactor, the s`, i~esseis, eta. are used. The laboratory is supplied with the gas required via a compressed gas line. 

### Description of the process The tectxical service laboratory employee is entrusted with the following tasks: Filling the vessel Controlling the plant Emptying the reactor Removing the product Determining the bulk density. 

# PUBLIC COP One run taices apprax. 45 min. Four runs were . completed durkV the 

### measurement period. d Technical protective measures - The experimental equipment is Installed in a walk-in fume hood. - Weighing takes place in the laboratory fume hood. 7 Measuring method The ambient air caonoeritration was determined by means of measurements at fixed ioc~s in accordance with the Technical Regulations fbr Hazardous Substances (TRGS 402) "Determination and Evaluation of Concentrations of Hazardous Substarncss in the Air in Woiidrg Arose and with the standards DIN EN 482 "Workplace Atmospheres - General Requirements for the Pe~ormanae of Pracedures for the MeasuremOnt of Chemical Agents" and DIN EN 689Workplace Atmospheres - Guidance for the Assessment of Exposure by Inhalation to Chemical Agents for Comparison with Limit Values and Measurement Strategy" . Sampling was perfamed using the criteria contained in DIN EN 481 "Workplace Atmosphere; Size Fraction Definitions for Measurement of Airbome Parficles' . This is implemented with the criteria for determining the inhaiable dust frection in accordance with the procedune "Measurement of Hazardous Substances", No . 3010in the BGIA instruction manual . 

### When using these sampling heads, an aspiration rate of 1 .25 m/s is assured 

## ~/ 72 ; I8 Sannpling conditlons The working and operating conditions during amblent air measurements corresponded with normal working and operating condbons. The measurements at fixed locations were carried out using a small batteryoperated pump of the type Buck-Cenie YSS 5 (company AP . Buck, Orlando, USA) . The dust sampiinp heads used were ofthe type BIA GSP 3 .5 fitted with a sudion cone for a flowrate of up to 3 .5 Umin to determine the inhalabie dust fraction. Atmospheric humidity and temperature data were measured using equipment made by EBRO Electronic (3mbH . Equipment type: EBt-2TH-811 (RS 2321) Serial no . : 305072 See the remits tebie for atmospheric data values. 8 Anaiyticai nathod Following equilibration, the dust load on the filter was measured grevimetricaliy by ditferentiai weighing. Foradaptation puupoees, the glass fiber fltter was protected fromdust and left to stand for two days in a chamber at room temperature before use and after loading. Scales made by the company Mettler, type AE 163, accurate to 10 pp, were used for diifenentiai weighing.o,t~: 2008-01-17 : 7 10 Test fewft : Substance: Inhaisble d Filling station in thlM



### No inhalable dust could be measured In the fted-location measurement at the filling station up to the determination twestiol

reshold limit is demonstrated/

_ fixther tx~otective meaaixes 

# PUBLIC COPY q7Z~p. 40



## odr . 200e-o1-17 Pspr: $

` c . ;

I 

# \ 

# PUBLIC-16,COPYp. 41



### Autbor: Measurement INN in Ambient Air at Worlc,olare

Performing Laboratory:

Laboratory Project ID

: 

# i BLIC COPY
CONTAINS CdNFIDF

.NTIAL BUSJNESSINFoRAI,lTI©N 2008-01-1S - Page I of 13. . 

# y7(e.42

Participants in the determination on site: 

# LIC COPY

CONTAINS CONFIDEIVTIAL BU'SIIVESSINFORMATION

2008-01-15 - Page 2of 13



### q'7 -7p. 43
Table ofContent 1 Reason for and scope ofthe exercise. . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . .. . . . . . .. . . . . . . . . . . . . . . . . 5 2 Description oftheworking area . . .. . . . . . . . . . . . . . . . . . . .. . .. . . . . . . . . . . . . . .. . . .. . . . . . .. . . .. . . . . . .. . . . . . . . . . .. . . . . . . . . . . . . . . . . . . 5 3 Nature ofthe plant and resources used. . . . . . . . .. . . . . . . . .. . . . . . . . . . .. . . . . . . . . . . . . . . . . . .. . .. . . . . . . . . . .. . . . . . .. . . .. . . . . . . . . . 5 4 Description ofthe process . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . 5 5 Technical protective measures.. . . . . . . . . . . . . . . . . . . . . . . .. . . .. . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . .. . . . . . . 6 6 Measuring System. . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . .. . .. . . .. . . . . . . . . . . . . . . .. . . . . . . . . . .. . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . .. . . . . . . . . . . . . . 6 6 .1 6 .2 6 .3 S) .. . .. . . .. . . .. . .. . . .. . . .. . .. . . .. . . .. . . .. . .. . . .. . .. . . .. . . .. . .. . .. . .. . .. . 6 L.. . . . . . . . . . .. . . .. . . .. . .. . . . . . .. . . .. . .. . . . . . . .. . . . . . . . . . .. . . . . . . . .. . . . . . . 7 e Dust Monitor (PDM) . . .. . . .. . .. . . .. . .. . .. . . .. . . .. . .. . . .. .. .. . . .. . .. . . .. . .. . . .. . . .. . .. . . .. . .. . . .. .. .. .. . .. . . . 7 6 .4 Transmission Electron Microscopy (TEM) . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . .. . . . . . . . . . . . 7 7 8 Sampling conditions . . . . . . . . . . . . . . . .. . . . . . . . . . .. . . . . . . . . . . . . . . . . . . .. . . . . . .. . . . .. . . . . . . . . .. . . . . . .. . . . .. . . . . . . . . .. . . . . . . . . . . . . . . . . . . . 8 Test Results. . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . .. .. . . . .. . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . .. . . . . . . . . .. 8 Az. . . . . . . . . . .. . . . . . . . .. . .. . . . . . . .. . . . . . . . . . .. . . . . . . . . . .. . . .. . . . . . .. . . . . . . . .. . . . . . . . . .. . . 8 r. .. . . .. . .. . . .. . .. . . .. .. . . . .. . . .. .. .. . .. . . .. .. . . . .. . .. . .. . . .. . . .. . .. . .. . . .. .. . . . 8 8.2.1 8.3 Long-termm

easuremenmut (6h) during routine batch-prod . . .. . .. . .10 

## 8.4 . ... . .. . ... .. .. .. ... . ... .... ... .. . .... . .. .. ... .. .. .... .-~~.. .. . .. .. ..11 9 Discussion. . .. . . . .. . . .. . . .. . .. . . . . .. .. . . .. . . .. . . .. . .. . . .. . .. . . .. . .. . . .. .. . .. .. .. . . .. . . .. . . .. . .. . . .. . . .. . .. . . . .. .. . . .. . . .. . .. .. . . . .. .. . .ll 10 Conclusion . . . . . . . . .. . . . .. . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . .. . . .. . . . . . . . . . . . . . . .. . . . . . . .. . . . . . .. . . .. . .. . . . . . . . . . .. . . .. . . . . . .. . . . .. . . . .12 11 Annex

. . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . .. . . . . . . . .. . . . . . .. . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . .. . . . .13 Table of Figures Figure 1 : Schematic representation ofan SMPS (Source Grimm Aerosoltechnik) . . . . . . .. . .. . . . . . . . . . . . . 7 Figure 2 : SMPS Measurement for Background . . . . . .. . . . . . . . .. . . .. . . . . . . . . . . . . . .. . .. . . . . . .. . .. . . .. . . .. . . .. . . . . .. . .. . . . . 9 Figure 3: SMPS measurement during normal production/sampling/fi . . . . . . .10 Figure 4 : SUPS meas ents during batch-production .. ~~

. . . . . . . . . . . . . . . . . . . . . . . . . . . .11 Figure 5 : Positio
. . . .. . . .. . .. . . . . . . . . . . . . . . . . . . .. . . . . . . .. . . . . . .. . . . . . . . . . .. . . . . . . . . . . . . . . . .. .. .13 Table ofTables Table 1 : Description ofthe Measuring Devices used . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . .. . . .. . . . . . 8

CONTAIIVSCONFIDENTIAL BU, 

## _. 20e8-01-r5-= Page 3offf 

# ~C COPY

y7FAbbreviations CPC Con Particle Counter DMA D' ' Mobility Analyzer W PDM Portable Dust Monitor SEM Scanning Electron Microscopy SMPS Scanning Mobility Particle Sizer TEM Transmission Electron Microscopy UHV Ultra-High Vacuum XPS X-ray Electron Spectroscopy 

# CO

CONTAINS CONFIDENTTAL BiISINESSINFORMATlON

200"1-15- Page 4 of 13



# y

### 1 Reason for and scope of'b"ise To determine the area of the production station when working wi ork involves production as well as routine sampling and filling activities. The measurement takes place at a fixed location. Measurements ofthe concentratio be conducted 40tthe same time. 

### 2 Description of the working area The technical dep The technical area is equipped with normal fume hoods and with walk-in free-standing fume hoods which deliver an sir exchange rate of 2000 m3/h . - test is carried outjust outside the free-standing fume hood where the prod~~cti place in a batch mama. Sampling and filliag are taking place in the other free-standing fume hood. An air exchange rate of approx. 5000 m'/h is specified for the bench row, while for the laboratory as a whole the air exchange rate is 20000 m'/h. The laboratory measures approximately 3.5 x 5 m with a height of approx. 3.2 m . The fivestanding fume hoods measure approx. 4 x 1 m andare approx. 2

.5 m high. One member of staff is responsible for the tesL In total there are 4 members of staff in the teclhnical service laboratory. 

### 3 Nature o the plant and resources used

synthesized in a discontinuous process in addition to the heated reactor, the usual technical resources es, are used. `The laboratory is supplied with the gas required via a compressed gas line. 

### 4 Description of the process The technical service laboratory employee is entrusted with the following tasks: - Filling the vessel - Controlling the plant - Emptying the reactor - Removing the product - Determining the bulk density 

# PUBLIC COPY One run takes approx. 45 min . Four runs were completed during the measurement period. CONTAINS CONFIDENTIAL BUSINESSMFORMATION

20t}8-~1-15 - Page 5 ~1~0 laborato such as v a ebc.

* V S. aW Sp. 46



### S Technical protective measures
- The experimental equipment is installed in awalk-in fume hood. - Weighing takes place in the laboratory fume hood. 6 Measuring System 

### 6 .1 Scanning Mobility Particle Slur (SMPS) Scanning Mobility Particle Sizer (SMPS) spectrometer is commonly used to measure size distributions in the range e SMPS spectrometer uses electrical mobility to measure the particle size. This technique utilizes a bipolar charga to impart a known charge distribution on the aerosol sample. The particles are then classified according to their ability to traverse an electric field. The classified particles are used as a seed for a butanol dropplet, which can measured/counted with simple light scatter methods. The SMPS system consists of a Differential Mobility Analyzer (DMA) coupled to a Condensation Particle Counter (CPC) . The DMA uses the mass dependent mobility of fine partic er electrical field in order to prepare a monodisperse aerosol for the CPC . Particle counting is then performed with the CPC . Through sequential run with different electrical currents in DMAit is possible to sort up to 44 size classes. The DMA-L used in this study is suited for a range The gas flowIn the systemis produced by a regulable pump b ' ia the CPC . An impactor is build in the gas inlet o the DMA with a separation '

radioactiv isotop (Americanuam 241) is used to ensure that the particles are charged in a definite manner after passing through the impactor. SMPS is shown schematically in Figure 1 . 

# LIC C

CONTAINS CONFIDENTLlL BIIsINESSINFORN"TION

"N-M-15- Page 6of 13p. 47

6 .3 Portable Dust Monitor (PD11) The dust particles are measured/counted by the physical principle of orthogonal light scattering. The measurement rang~ . 

### 6 .4 Transmission Electron Microscopy (TEM) Traasmission electron microscopy (TE1Vn is an imaging technique whereby a beam ofelectrons is transmitted through a specimen, then an image is formed, magnified and directed to be detected by a sensor such as a C M allowed the production of images with sufficient resolution in the range 

# PUBLIC COPY Specific instruments used in this study are listed in Table 1 .

CONTAINS CONFIDENTIdL BUSINESS INFORM4TION

2009-01-15 - Page 7of 23

~~ZTable 1 : Description ofthe Measuring Devices used Measuring devices Description Type Manufacturer Particle Gas Additional Size range Flow information 

### [ca. nmj' [1/min] SMPS-L 5403 Grimm Aerosoltechnik 0 .3 Condensation GmbH particle counter PDM 1 .108 Grimm Aerosolteehnik 1 .3 Optical particle GmbH ~--r counter 3089 TSI Inc

. 1 .5 Collector /TEM , 

### 7 Sampling conditions

in Figure 2 . The working and operating conditions during ambient air measurements corresponded with normal working and operating conditions. The sampling is performed in front of the fume hood with the reactor located inside. The door is closed. The point of entry fromSN1PS is at a height of 1 .5m . (see Figure 5 in Annex) . 

### 8 Test Results 8 .1 Backgound measurement 8 .1 .1 S --- The background consisted in having no activity at all within the lab (incl ' production) . At least 24h elapsed between the last production campagne and the background measurement. The measurement was performed on 2005-10-26 (09 :32 . :7 10:04) . The atmospheric conditions were: P,b,=1011 hPa, f j= 45 .8 % ; e concentration of particles in the 

# UBLIC COPY CONTAINS CONFIDE]VTLU BUSINESS INFOMUTION

2008-O1-15 - Page 8of 13



## L{ S3Figure 2: SMP9lkisatonaent for Hwkgroand 8 .1.2 P The number Of particles (in the range the background was perfinmed using PDM

. 'The measn~ements showed a conce~tion of 0.18N/cm3 (181 scans,181 min.). 8 .2 Measurement during routine produtdoWumpling4m .- W--~) The measurement was performed on 2005-10-26 (10:13 - 10 :53) . no atmospheric conditions were: Paw- 1011 hPa, &- 44.6 OA, T- 23.3 °C . . . . . The measurement is .. -shwA%-yn Figure 3. concentration of particles in the 

# LIC

CONTAINS CONFIDENTIAL BUSINESS INF08MATION

-- -13, -- ------ - ------Figure 3 : SMPS measurement during normal production/sampling/titling of Baytubes 8 .2 .1 PDMINO The number of particles . productionlsamDlin filling 

### 8 .3 Long-term

measurement (6h) during routine batch

# Pu 6 L(G 0 P ~
CONTAINS CONFIDENTIAL BUSIIVESSINFORMATION

2008-01-15 - Page 10 of 13



# y fS-