2

The maximum proposed application rate for the proposed foliar uses is for dry shelled beans 

(except soybeans), at 0.18 lbs ai/acre/application, applied 2 times per year with a 7-day reapplication 

interval for a maximum total annual application rate of 0.36 lb ai/A/yr. The maximum proposed 

application rate for the proposed new seed uses is for wheat and triticale seed, at 0.068 lbs 

ai/acre/application, applied one time per year for a maximum total annual application rate of 0.068 lb 

ai/A/yr. This application rate is based on an application rate of 0.05 lbs ai per 100 lbs of seed and an 

assumed planting rate of 135 lbs of seed planted per acre (USEPA model TREX Version 1.4.1 

[http://www.epa.gov/oppefed1/models/terrestrial/index.htm#trex]) and a planting depth of 2 inches.

The computer models FIRST (surface water) and SCIGROW (groundwater) were used to predict

the EDWCs for use in the human health dietary risk assessment. Fluxapyroxad is the only residue of 

concern in drinking water.

For aerial applications to dry shelled beans (except soybeans), the estimated acute concentration 

of fluxapyroxad in surface water sources of drinking water is 14.1 μg/L. The estimated chronic 

concentration is 6.7 μg/L. The acute and chronic values for wheat and triticale seed applications were 

1.22 and 0.55 ppb, respectively. The FIRST output file is provided in Appendix B.

For groundwater sources of drinking water, the estimated concentration of fluxapyroxad in 

shallow groundwater for applications to dry shelled beans (except soybeans) is 0.087 μg/L. The reported 

value for wheat and triticale seed applications is 0.017 ppb. The SCIGROW output file is provided in 

Appendix B.

Maximum EDWCs for fluxapyroxad in surface water and groundwater are presented below in

Table 1; complete modeling results are presented in Table 6.

Table 1. Maximum Tier I estimated drinking water concentrations for fluxapyroxad use.

DRINKING 

WATER SOURCE 

(MODEL USED)

USE (rate modeled) MAXIMUM ESTIMATED 

DRINKING WATER 

CONCENTRATION (EDWC) ( ppb)

1-in-10 year acute 

(μg/L)

1-in-10 year 

chronic (μg/L)

Surface Water 

(FIRST)

Aerial Foliar 

(dry shelled beans at 0.18 lbs ai/A x 2) 14.1 6.70

Groundwater 

(SCIGROW)

Aerial Foliar 

(dry shelled beans at 0.18 lbs ai/A x 2) 0.087 0.087

This assessment is based on available environmental fate data. There are no significant data gaps 

in the environmental fate database submitted by the registrant. Since this is a new chemical there is no 

existing monitoring data for fluxapyroxad.

PROBLEM FORMULATION

This is a Tier I drinking water assessment (DWA) that uses modeling to estimate the groundwater 

and surface water concentrations of pesticides in drinking water source water (pre-treatment) resulting

from pesticide use on sites that are vulnerable. Tier I DWAs are designed to screen out chemicals with 

low potential risk for posing a drinking water concern.
3

ANALYSIS

Use Characterization

Fluxapyroxad (BAS 700 F) is a second generation carboxamide fungicide, designed to inhibit the 

mitochondrial respiratory chain (Complex II Succinate Dehydrogenase, SDH). It is being proposed for a 

number of crops including wheat, barley, corn, bean and pea legumes, peanuts, pome and stone fruits, 

fruiting vegetables, oil seed, root and tuberous vegetable crops. It is also being proposed as a seed 

treatment for use on barley, corn, cotton, dried shelled peas and beans, edible podded legume vegetables, 

oat, peanut, rye, sorghum, soybean, sunflower, wheat and triticale seed. Two of the proposed products

(BAS 703 01 F and BAS 703 02 F) also contain the active ingredient pyraclostrobin, which is being 

proposed at application rates equivalent to or higher than fluxapyroxad. This evaluation is limited to the 

exposure associated with fluxapyroxad alone and does not include exposure associated with 

pyraclostrobin. 

Application information for the proposed new use on dry shelled beans (except soybeans) and 

wheat and triticale seed applications is presented in Table 2. A complete listing of the proposed new 

uses for fluxapryoxad products is provided in Appendix A.

Table 2. Summary use information for fluxapyroxad proposed new use on dry shelled beans (except 

soybeans) and wheat and triticale seed applications.

Use

Max. Single 

Application 

Rate

(lbs. a.i./A)

No. of 

Applications

Annual 

Application

Rate

(lbs. a.i./A/yr)

Interval 

Between 

Applications

(days)

Application

Method

Dry shelled beans 

(except soybeans)

0.18 2 0.36 7 Aerial

Wheat and triticale 

seed applications 0.068 1 0.068 NA Incorporated

Environmental Fate and Transport Characterization

Fluxapyroxad is stable to hydrolysis at pH of 5, 7 and 9; and to both soil and aqueous photolysis. 

Fluxapyroxad is not expected to volatilize (vapor pressure greater than 6.1 x 10-11 Torr at 25 ̊ C). 

Fluxapyroxad does not readily undergo aerobic or anaerobic degradation in soil, with single first-order 

half-lives ranging from 213 to 1,827 days. There did not appear to be any relationship between soil 

metabolism half-lives and pH, organic carbon, or cation exchange capacity. It should be noted, though, 

that low CO2 levels were observed in the aerobic soil metabolism studies, as well as a lack of 

transformation product formation, an increase in unextracted residue formation with an increase in 

temperature without an effect on CO2 and transformation product formation, and the detection of parent in 

unextracted residue (MRID 47923684). Coupled with the fact that fluxapyroxad is moderately to slightly 

mobile (see mobility discussion below), there is the potential that the half-life values determined in these 

studies are more representative of adsorption than of biotransformation.

 

Fluxapyroxad does not readily undergo aerobic or anaerobic degradation in aquatic systems, with 

single first-order half-lives ranging from 420 to 731 days. In aerobic aquatic studies, fluxapyroxad 
4

partitioned to sediment, reaching levels in sediment above 50% of the applied between 3 and 7 days after 

treatment. 

In the terrestrial field dissipation studies conducted on bare soil at six locations throughout North 

America, fluxapyroxad was detected infrequently below the top 6 inches of the soil, dissipating with halflives ranging from 17 to 436 days. 

Fluxapyroxad is classified as moderately to slightly mobile (FAO soil mobility classification) 

based on adsorption KOC values in two U.S. soils ranging from 725 to 1,200 mL/goc. Adsorption KOC

values for six foreign soils were similar, ranging from 496 to 1,424 mL/goc. Freundlich soil partitioning 

coefficients (KF) for adsorption for the two U.S. soils ranged from 2.5 to 8.6 ml/g (4.3 to 17.9 ml/g for 

foreign soils). Fluxapyroxad has the potential to leach to ground water, particularly where high water 

tables are present, high rainfall/irrigation occurs, and where sandy soils with low organic matter exist. As 

mentioned above, in the majority of terrestrial field dissipation studies, fluxapyroxad was detected 

infrequently at depths greater than 6 inches. However, given fluxapyroxad’s persistence and mobility, the 

terrestrial field dissipation studies, which only lasted a maximum of 472 days, may not have been long 

enough to capture leaching over time.

A bioconcentration in fish (BCF) laboratory study involving bluegill sunfish (MRID 47923730) 

indicated that after 28 days of exposure to fluxapyroxad (1.0 and 10.0 μg a.i./L), whole fish BCF values 

(based on total radioactivity) were 86 and 93 (μg/kg-ww per μg/L), respectively. Time to reach 90% 

depuration was 2.5 and 2.4 days, respectively. Therefore, fluxapyroxad will not likely bioaccumulate.

A summary of the maximum amount of degradation products in the studies discussed above is 

provided in Appendix C. Based on discussions with the Residues of Concern Knowledgebase 

Subcommittee (ROCKS), only the parent compound is of concern for drinking water purposes (D390225, 

7/14/2011).

Table 3 summarizes the physicochemical properties of fluxapyroxad. 

Table 3. Physical and chemical properties for fluxapyroxad.

Chemical Fate/Parameter Value Source

(MRID) Comments

IUPAC Name 3-(difluoromethyl)-1-methyl-N-

(3',4',5'-trifluoro[1,1'-biphenyl]-2-

yl)-1 H-pyrazole-4-carboxamide

Chemical Formula C18H12F5N3O

Chemical Structure

Molecular Mass (g/mol) 381.31

Vapor Pressure (25°C) (Torr) 6.1 x 10-11 47923505 Not expected to

volatilize

Solubility (20°C) (ppm) 3.44 (pH 7) 47923509

Octanol-water partition 

coefficient (Kow)

1,288 (log Kow = 3.11) 47923511

Dissociation constant (pKa) 12.58 47923514
5

Chemical Fate/Parameter Value Source

(MRID) Comments

Hydrolysis half-life 

(pHs 5,7,9; 25 °C)

No evidence of degradation at all 

three pHs

48409101

Aqueous photolysis half-life No evidence of degradation 47923513

Soil photolysis half-life No evidence of degradation 47923690

Aerobic soil metabolism halflife; soil texture213 days (NJ, loam)1

1,827 days (ID, sandy loam) 2

676 days (IL, loam) 2

387 days (WI, loamy sand) 2

47923684 No observed 

correlation between 

half-lives and 

individual soil 

729 days (CA, sandy loam) properties. 2

295 days (GA, sandy loam) 2,3

345 days (IN, loam) 2,3

238 days (NC, sandy loam) 2,3

47923691

Anaerobic soil metabolism 

half-life; soil texture

591 days (NJ, loam) 247923688

Aerobic aquatic metabolism 

half-life 

420 days (silt loam) 2

701 days (sand) 2

47923713 Partitioned mainly to 

sediments

Anaerobic aquatic metabolism 

half-life

731 days 47923714 Supplemental

Range of Freundlich soil 

partition coefficients (KF, 

mL/g) for adsorption; 

8.6 (NJ, silt loam)

2.5 (CA, sandy loam)

6.8 (Germany, loamy sand)

4.2 (Germany, sand)

5.7 (Germany, loamy sand)

12.3 (Spain, silty clay)

18.3 (Germany, clay silt)

14.0 (Japan, sandy silt)

47923707 Six foreign soils 

found to be 

representative of 

agricultural areas 

where the pesticide 

will be used.

Range of organic carbon 

partition coefficients (K oc, 

mL/goc)

1,195 (NJ, silt loam)

725 (CA, sandy loam)

981 (Germany, loamy sand)

978 (Germany, sand)

827 (Germany, loamy sand)

496 (Spain, silty clay)

1,424 (Germany, clay silt)

819 (Japan, sandy silt)

47923707 Six foreign soils 

found to be 

representative of 

agricultural areas 

where the pesticide 

will be used.

Terrestrial field dissipation 

half-life 

76 days (MB4, clay loam)

16.7 days (TX, clay loam)

120 days (IL, silt loam)

332 days (NY, sandy loam)

314 days (CA, sandy loam)

436 days (WI, sand)

47923695

47923696

47923697

All applications 

were to bareground.

Bioconcentration factor 86-93(whole fish) 47923730

1 Estimates using the first-order, multiple-compartment (FOMC) provided a better fit to the data, but, as single firstorder (SFO) estimates are used in modeling, the half-life presented is from a SFO fit of the data.

2 Half-lives extrapolated beyond length of studies (368 days for MRID 47923684, 120 days for MRID 47923691, 

123 days for MRID 47923688, 100 days for MRID 47923713, and 365 days for MRID 47923714).

3 These estimates are based on SFO. Based on the interim EFED kinetics modeling guidance, SFO is not applicable 

and these values can be as high as 613 (GA), 2,580 (IN), and 1,561 (NC) days.

4 MB – Manitoba, Canada
6

Drinking Water Exposure Modeling

Models

Estimated Drinking Water Concentrations (EDWCs) in surface water was estimated using 

EFED’s Tier I aquatic model FIRST (v1.1.1; 3/25/08). FIRST (FQPA Index Reservoir Screening Tool) is 

a metamodel of PRZM and EXAMS used as a screening tool to estimate pesticide concentrations found in 

surface water used as drinking water. FIRST was developed by making multiple runs of PRZM using 

varying sorption coefficients and determining the concentration in the EXAMS index reservoir scenario 

after a two-inch single storm event. The Index Reservoir is a standard water body used by the Office of 

Pesticide Programs to assess drinking water exposure (Office of Pesticide Programs, 2002). It is based on 

a real reservoir (albeit not currently in active use as a drinking water supply), Shipman City Lake in 

Illinois, that is known to be vulnerable to pesticide contamination). The single runoff event moves a 

maximum of 8% of the applied pesticide into the reservoir. This amount can be reduced by degradation 

or effects of binding to soil in the field. Additionally, FIRST can account for spray drift and adjusts for 

the area within a watershed that is planted with the modeled crop (Percent Cropped Area). Spray drift 

(modeled as direct deposition of the pesticide into the reservoir) is assumed to be 16% of the applied 

active ingredient for aerial application, 6.3% for orchard air blast application, and 6.4% for other ground 

spray application. Despite being a single event model, FIRST can account for spray drift from multiple 

applications. The Percent Cropped Area (PCA) of 87% was used for the dry shelled beans (except 

soybeans) and wheat/triticale seed application new uses. The PRZM scenario used for FIRST 

development was among the most vulnerable, and thus resulting surface water concentrations represent 

the upper bound values on the concentrations that might be found in drinking water from the use of a 

pesticide. (Ref. 2 and 3)

An EDWC in groundwater was estimated using EFED’s Tier I groundwater model SCIGROW 

(Screening Concentration in Ground Water, version 2.3; 8/8/2003). SCIGROW is a regression model 

used as a screening tool to estimate pesticide concentrations found in ground water used as drinking 

water. SCIGROW was developed by fitting a linear model to groundwater concentrations with the 

Relative Index of Leaching Potential (RILP) as the independent variable. Groundwater concentrations 

were taken from 90-day average high concentrations from Prospective Ground Water studies; the RILP is 

a function of aerobic soil metabolism and the soil-water partition coefficient. The output of SCIGROW 

represents the concentrations that might be expected in shallow unconfined aquifers under sandy soils, 

which is representative of the ground water most vulnerable to pesticide contamination likely to serve as a 

drinking water source. (Ref. 1)

Modeling Approach and Input Parameters

Tier I modeling was conducted for the EDWCs in surface water and groundwater from 

fluxapyroxad use on dry shelled beans (except soybeans) at 0.18 lbs ai/acre/application, applied 2 times 

per year with a 7-day reapplication interval for a maximum total annual application rate of 0.36 lb ai/A/yr. 

Modeling was also done for wheat and triticale seed treatment application at 0.068 lbs ai/acre/application, 

applied one time per year for a maximum total annual application rate of 0.068 lb ai/A/yr. 

Physical/chemical properties and environmental fate source data (from submitted studies) were presented 

in Table 3. Input values used for surface water modeling with FIRST are presented in Table 4. Input 

values used for groundwater modeling with SCIGROW are presented in Table 5. 

In running FIRST, the mean adsorption coefficient (Koc = 931 mL/goc) was used because the Koc

model is valid for this compound (i.e., binding was correlated with organic carbon). In running
7

SCIGROW, however, the median Koc value of 902 mL/goc (median value) was used, per guidance. In 

running FIRST, an aerobic soil metabolism half-life of 857 days was used, as it represents the 90th

percentile on the mean for 8 available half-lives. In running SCIGROW, an aerobic soil metabolism halflife of 366 days was used, as it represents the median value for these eight half-lives. It should also be 

noted that there was five-fold difference in the range of the values. To simulate seed treatment 

application, a granular application was used in FIRST to eliminate spray drift and allow for an 

incorporation depth of 2 inches for the seeds.

Table 4. Input values for the FIRST model for fluxapyroxad.

Variable Name Data Value

Data Source

MRID(s) Comment

Application Method Aerial (dry shelled beans), 

granular (wheat/triticale seeds)

Proposed 

labels

Application Rate (lbs. 

ai/acre)

0.18 (dry shelled beans ), 

0.068 (wheat/triticale seeds)

Proposed 

labels

Application Frequency 2 (dry shelled beans), 

1 (wheat/triticale seeds)

Proposed 

labels

Application Interval 

(days)

7 (dry shelled beans), 

not applicable (wheat/triticale seeds)

Proposed 

labels

Incorporation depth (in) 0 (dry shelled beans), 

2 (wheat/triticale seeds) --

No incorporation for 

foliar application, 2 

inches assumed for 

seeds

Solubility 3.44 ppm 47923509

Hydrolysis t1/2 = stable 48409101

Photolysis t1/2 = stable 47923513

Aerobic Soil Metabolism t1/2 = 857 days 47923684,

47923691

90th percentile on 

mean (589 days) of 8 

values1

Aerobic Aquatic 

Metabolism t1/2 = 993 days 47923713

90th percentile on 

mean (561 days) of 2 

values1

Koc 931 mL/goc 47923707 Mean of eight values1

1

EFED input parameter guidance is located at: http://www.epa.gov/oppefed1/models/water/input_parameter_guidance.htm

Table 5. Input values for the SCIGROW model for fluxapyroxad.

Variable Name Data Value

Data Source

MRID(s) Comment

Application Rate (lbs. 

ai/acre)

0.18 (dry shelled beans ), 

0.068 (wheat/triticale seeds)

Proposed 

labels

Application Frequency 2 (dry shelled beans), 

1 (wheat/triticale seeds)

Proposed 

labels

Aerobic Soil Metabolism t1/2 = 366 days 47923684,

47923691

Median value of 8 

values ranging from 

213 to 18271
8

Variable Name Data Value

Data Source

MRID(s) Comment

Koc 902 mL/goc 47923707 Median of eight 

values1

1

EFED input parameter guidance is located at: http://www.epa.gov/oppefed1/models/water/input_parameter_guidance.htm

Modeling Results

Tier I surface water and groundwater modeling results for fluxapyroxad for aerial application to 

dry shelled beans and seed applications are presented in Table 6. These values are recommended for use 

in the human health risk assessment. An analysis of ground application of fluxapyroxad was also 

conducted, but the acute and chronic EDWCs were lower than those for aerial applications. Output 

values for surface water are modified using the PCA adjustment factor of 0.87. Output values for 

groundwater are not adjusted for a PCA. Outputs from the model runs are provided in Appendix B.

Table 6. Tier I estimated drinking water concentrations based on fluxapyroxad use. 

DRINKING WATER 

SOURCE (MODEL 

USED)

USE (rate modeled)

MAXIMUM ESTIMATED DRINKING 

WATER CONCENTRATION (EDWC) ( ppb)

1-in-10 year acute

(μg/L)

1-in-10 year 

chronic (μg/L)

Surface Water 

(FIRST)

Aerial Foliar 

(dry shelled beans at 0.18 lbs ai/A x 2) 14.11

6.70

Seed

(wheat/triticale at 0.068 lbs ai/A x 1) 1.22 0.55

Groundwater 

(SCIGROW)

Aerial Foliar 

(dry shelled beans at 0.18 lbs ai/A x 2) 0.087 0.087

Seed

(wheat/triticale at 0.068 lbs ai/A x 1) 0.017 0.017

1

Bolded values are recommended for use in the human health dietary risk assessment.

The SCIGROW concentration represents the groundwater concentration that might be expected in 

shallow unconfined aquifers under sandy soils. The output is used for both acute and chronic endpoints.

FIRST concentrations (ppb) represent untreated surface water concentrations. The one-in-10-year 

peak day concentration is used for acute endpoints and the one-in-10-year annual average concentration is 

used for chronic endpoints. 

The estimated concentrations provided in this assessment are conservative estimates of 

concentrations in drinking water. If dietary risks require refinement, higher tiered crop-specific and 

location-specific models and modeling scenarios can be used.

Monitoring Data

As fluxapyroxad is a new active ingredient, no monitoring data are available.

Drinking Water Treatment Effects

As fluxapyroxad is a new active ingredient, no specific information on the effects of drinking 

water treatment is available. The EDWCs in this assessment are representative of concentrations in 

drinking water source water (pre-treatment) and are derived from daily instantaneous peak concentrations. 
9

For surface water, the conceptual model assumes that a pesticide reaches surface water via spray drift or 

surface runoff, where it is instantaneously mixed and concentrations are observed in the water body. 

Fluxapyroxad is stable to hydrolysis, therefore it will not degrade during the time that elapses from 

drinking water intake through distribution to the first tap. Because of its Koc values, treatment methods,

such as sedimentation, flocculation, and activated carbon, are expected to be marginally effective at 

removing fluxapyroxad. Fluxapyroxad also does not degrade due to photolysis. If ultraviolet light were 

used as a means of disinfection, degradation of fluxapyroxad would not be expected. 

Uncertainties and Data Gaps

This assessment is based on available environmental fate data. There are no significant data gaps 

in the environmental fate database submitted by the registrant. The Tier I drinking water assessment is a 

screening-level assessment based on simplified models and assumptions. The modeling assessment relies

on maximum use patterns and national default PCAs to reflect potential surface and groundwater 

concentrations. To the extent that actual use patterns are less than the labeled maximums and the 

location-specific PCAs are less than assumed in this assessment, actual environmental exposures could be 

lower.

As noted in the Fate section, low CO2 levels were observed in the aerobic soil metabolism

studies, as well as a lack of transformation product formation, an increase in unextracted residue 

formation with an increase in temperature without an effect on CO2 and transformation product 

formation, and the detection of parent in unextracted residue (MRID 47923684). Coupled with the fact

that fluxapyroxad is moderately to slightly mobile in soil, there is the potential that the half-life values 

determined in these studies are more representative of adsorption than of biotransformation. 

Consequently, there is the potential for fluxapyroxad to accumulate in soils via adsorption and not 

degrade, such that at some point the sorption sites could become overwhelmed and fluxapyroxad could 

more easily be transported to surface water via runoff. While there is some uncertainty surrounding the 

aerobic soil half-lives, given the low application rates for fluxapyroxad the potential to overwhelm 

sorption sites is considered low.

References

1. SCIGROW: Users Manual (11/01/2001, revised 08/23/2002)

2. FIRST Users Manual (03/26/2008)

3. FIRST: A Screening Model to Estimate Pesticide Concentrations in Drinking Water (03/26/2008)

4. Guidance for Selecting Input Parameters in Modeling the Environmental Fate and Transport of 

Pesticides, Version 2.1 (10/22/2009) 

(http://www.epa.gov/oppefed1/models/water/input_parameter_guidance.htm)

5. Development and Use of Percent Cropped Area Adjustment Factors in Drinking Water Exposure 

Assessments (9/9/2010) (http://www.epa.gov/oppefed1/models/water/pca_adjustment_dwa.html)

MRIDs

MRID: 47923505

Kroehl, T. (2006) Physical Properties: Pure Active Ingredient. Project Number: 2006/1036276/OCR, 

267469/1/OCR. Unpublished study prepared by BASF Aktiengesellschaft. 20 p.
10

MRID: 47923509

Wilfinger, W. (2008) Water Solubility of BAS 700 F at 20 Degrees Celsius. Project Number: 

2007/1056999/OCR, 267487/1EXT/OCR, 20071489/01/PCSB. Unpublished study prepared by EurofinsGAB GmbH. 53 p.

MRID: 47923511

Wilfinger, W. (2008) Partition Coefficient of BAS 700 F (HPLC Method). Project Number: 

2007/1057001/OCR, 20071489/01/PCPC/OCR, 267475/1EXT. Unpublished study prepared by Eurofins 

- GAB GmbH. 42 p.

MRID: 47923513

Hassink, J. (2009) Aqueous Photolysis of BAS 700 F. Project Number: 2009/1031228/OCR, 

314718/OCR. Unpublished study prepared by BASF Aktiengesellschaft. 26 p.

MRID: 47923514

Wilfinger, W. (2008) Dissociation Constant of BAS 700 F in Water. Project Number: 

2007/1057000/OCR, 267478/1EXT/OCR, 20071489/01/PCDC. Unpublished study prepared by Eurofins 

- GAB GmbH. 30 p.

MRID: 47923684

Malinsky, D. (2010) Aerobic Soil Metabolism of (Carbon 14)-BAS 700 F on US Soils: Final Report. 

Project Number: 2009/7003246/ocr, 002/57/01//US/319649, 2009/7003246. Unpublished study prepared 

by BASF Agricultural Research Center. 139 p.

MRID: 47923688

Malinsky, D. (2010) Anaerobic Soil Metabolism of (Carbon 14)-BAS 700 F on US Soil: Final Report. 

Project Number: 2009/7003247/ocr, //SubNo/201002/56/01, 2009/7003247. Unpublished study prepared 

by BASF Agricultural Research Center. 131 p.

MRID: 47923690

Hassink, J. (2009) Soil Photolysis of BAS 700 F. Project Number: 2009/1013342/US/ocr, EU/314704, 

2009/1013342. Unpublished study prepared by BASF SE. 42 p.

MRID: 47923691

Ta, C. (2010) Rate of Degradation of BAS 700 F in Soils: Final Report. Project Number: 

2009/7006123/ocr, //SubNo/201002/37/01, 209/7006123. Unpublished study prepared by BASF 

Agricultural Research Center and Agvise, Inc. 133 p.

MRID: 47923695

Jordan, J.; Warren, R. (2010) Terrestrial Field Dissipation of BAS 700 F Following Applications of BAS 

700 AC F in Legumes. Project Number: 2009/7006030/ocr, //SubNo/201003/03/01, 2009/7006030. 

Unpublished study prepared by BASF Agricultural Research Center. 293 p.

MRID: 47923696

Jordan, J.; Warren, R. (2010) Terrestrial Field Dissipation of BAS 700 F Following Applications of BAS 

700 AC F or BAS 700 AE F in Vegetable Use Patterns. Project Number: 2009/7006032/ocr, 

//SubNo/201003/02/01, 2009/7006032. Unpublished study prepared by BASF Agricultural Research 

Center. 756 p.
11

MRID: 47923697

Jordan, J. (2010) Terrestrial Field Dissipation of BAS 700 F Following Applications of BAS 700 AC F in 

Orchard and Vineyard Use Patterns. Project Number: 2009/7006033/ocr, //SubNo/201002/60/01, 

2009/7006033. Unpublished study prepared by BASF Agricultural Research Center. 505 p.

MRID: 47923707

Hassink, J.; Stephan, A. (2009) Determination of the Adsorption/Desorption Behaviour of BAS 700 F on 

Different Soils. Project Number: 2009/1065633/OCR, 2009/1065633, 314706. Unpublished study 

prepared by BASF Aktiengesellschaft. 78 p.

MRID: 47923713

Ebert, D. (2009) Degradation of BAS 700 F in Water/Sediment Systems under Aerobic Conditions. 

Project Number: 2009/1004082/OCR, 2009/1004082, 314715. Unpublished study prepared by BASF 

Aktiengesellschaft. 151 p.

MRID: 47923714

Ta, C. (2010) BAS 700 F: Anaerobic Aquatic Metabolism. Project Number: 2009/7006124/OCR, 

2009/7006124, 319648. Unpublished study prepared by BASF Agro Research and Agvise Laboratories, 

Inc. 105 p.

MRID: 47923730

Hafemann, C.; Kloeppner, U. (2009) Bioconcentration and Metabolism of BAS 700 F in Bluegill Sunfish 

(Lepomis macrochirus). Project Number: 2009/1012801/OCR, 2009/1012801, 315780. Unpublished 

study prepared by BASF Aktiengesellschaft. 163 p.

MRID: 48409101

Hassink, J. (2011) BAS 700 F: Aqueous Hydrolysis at Four Different pH Values (Including Amendment 

No. 1). Project Number: 324301, 2011/7000318. Unpublished study prepared by BASF 

Aktiengesellschaft. 19 p.
12

Appendix A

Proposed products for registration containing fluxapyroxad

Proposed 

New End-Use 

Product Name

Summary Formulation Details:

Formulation Type

lb fluxapyroxad/gal of product

(lb ai pyraclostrobin/gal of product)

Application Type Crops

BAS 700 01 F 

Fungicide

Reg No. 7969-XXX

Emulsifiable Concentrate

0.52

Foliar

Aerial and ground

Wheat, barley, corn, bean and pea legumes, 

peanuts, pome and stone fruits, fruiting 

vegetables, oil seed, root and tuberous vegetable 

crops.

BAS 700 02 F 

Fungicide Seed 

Treatment

Reg No. 7969-XXX

Suspension Concentrate

0.78 Seed Treatment

Barley, corn, cotton, dried shelled peas and 

beans, edible podded legume vegetables, oat, 

peanut, rye, sorghum, soybean, sunflower, wheat 

and triticale seed

BAS 700 03 F 

Fungicide Seed 

Treatment

Reg No. 7969-XXX

Suspension Concentrate

2.72 Seed Treatment

Barley, corn, cotton, dried shelled peas and 

beans, edible podded legume vegetables, oat, 

peanut, rye, sorghum, soybean, sunflower, wheat 

and triticale seed

BAS 700 04 F 

Fungicide

Reg No. 7969-XXX

Suspension Concentrate

2.47

Foliar

Aerial and ground

Cereals, bean and pea legumes, peanuts, pome 

and stone fruits, fruiting vegetables, oil seed, 

root and root and tuberous vegetable crops

BAS 703 01 F 

Fungicide

Reg No. 7969-XXX

Suspension Concentrate

2.09

(2.09 Pyraclostrobin)

Foliar

Aerial and ground

Pome and stone fruits, fruiting vegetables, oil 

seed, soybean, and root and tuberous vegetable 

crops.

BAS 703 02 F 

Fungicide

Reg No. 7969-XXX

Suspension Concentrate

1.39

(2.78 Pyraclostrobin)

Foliar

Aerial and ground

Cereals, fruiting vegetables, oilseed crops, 

peanut, soybean, and root and tuber vegetables 

crops.
13

Proposed Use Information for Fluxapyroxad Products

EUP Crop

Max Single 

App Rate

(lbs ai/A)

Number of 

Applications

Minimum

Retreatment 

Interval

Max Annual 

App Rate

(lbs ai/A)

Notes

BAS 700 01F

Barley 0.089 2 NS 0.18 1

Corn 0.089 2 7 0.18 1

Dried shelled peas (except 

soybean) 0.089 2 7 0.18 1

Dried shelled beans (except 

soybean) 0.18 2 7 0.36 1

Edible podded legume vegetables 0.089 2 7 0.18 1

Fruiting vegetables 0.089 3 7 0.27 1

Oat 0.089 2 NS 0.18 1

Oilseed crops, canola/rapeseed 0.089 2 14 0.18 1

Oilseed crops, other 0.089 2 7 0.18 1

Peanut 0.089 3 14 0.27 2

Pome fruits 0.089 4 7 0.36 1

Rye 0.089 2 NS 0.18 1

Soybean 0.089 2 14 0.18 1

Stone fruits 0.110 3 7 0.33 1

Succulent shelled peas and beans 0.089 2 7 0.18 1

Sugar beet 0.089 3 14 0.27 2

Tuberous and corm vegetables 0.089 3 7 0.27 2

Wheat, triticale 0.089 2 NS 0.18 1

BAS 700 02F 

and BAS 700 

03F

Barley seed 0.05 1 NA 0.05 Based on 100 lbs seed/acre

Corn seed 0.013 1 NA 0.013 Based on 25 lbs seed/acre

Cotton seed 0.004 1 NA 0.004 Based on 18 lbs seed/acre

Dried shelled pea and bean seed 0.016 1 NA 0.016 Based on 160 lbs seed/acre

Edible podded legume vegetable 

seed 0.023 1 NA 0.023 Based on 225 lbs seed/acre

Oat seed 0.013 1 NA 0.013 Based on 128 lbs seed/acre

Peanut seed 0.014 1 NA 0.014 Based on 135 lbs seed/acre
14

EUP Crop

Max Single 

App Rate

(lbs ai/A)

Number of 

Applications

Minimum

Retreatment 

Interval

Max Annual 

App Rate

(lbs ai/A)

Notes

Rye seed 0.015 1 NA 0.015 Based on 150 lbs seed/acre

Sorghum seed 0.002 1 NA 0.002 Based on 8 lbs seed/acre

Soybean seed 0.016 1 NA 0.016 Based on 160 lbs seed/acre

Sunflower seed 0.02 1 NA 0.020 Based on 100 lbs seed/acre

Wheat, triticale seed 0.068 1 NA 0.068 Based on 135 lbs seed/acre

BAS 700 04F

Barley 0.087 2 NS 0.17 1

Corn 0.17 1 7 0.17 1, 3

Dried shelled peas (except 

soybean) 0.087 2 7 0.17 1

Dried shelled beans (except 

soybean) 0.174 2 7 0.35 1

Edible podded legume vegetables 0.087 2 7 0.17 1

Fruiting vegetables 0.087 3 7 0.26 1

Oat 0.087 2 NS 0.17 1

Oilseed crops, canola/rapeseed 0.087 2 14 0.17 1

Oilseed crops, other 0.087 2 7 0.17 1

Peanut 0.087 3 14 0.26 2

Pome fruits 0.087 4 7 0.35 1

Rye 0.087 2 NS 0.17 1

Soybean 0.087 2 14 0.17 1

Stone fruits 0.108 3 7 0.32 1

Succulent shelled peas and beans 0.087 2 7 0.17 1

Sugar beet 0.087 3 14 0.26 2

Tuberous and corm vegetables 0.087 3 7 0.26 2

Wheat, triticale 0.087 2 NS 0.17 1

BAS 703 01F

Fruiting vegetables 0.089 3 7 0.27 1

Oilseed crops, canola/rapeseed 0.089 2 14 0.18 1

Oilseed crops, other 0.089 2 7 0.18 1

Pome fruits 0.089 4 7 0.36 1
15

EUP Crop

Max Single 

App Rate

(lbs ai/A)

Number of 

Applications

Minimum

Retreatment 

Interval

Max Annual 

App Rate

(lbs ai/A)

Notes

Soybean 0.089 2 7 0.18 1

Stone fruits 0.109 3 7 0.32 1

Tuberous and corm vegetables 0.089 3 7 0.27 2

Wheat, triticale 0.089 2 NS 0.18 1

BAS 703 02F

Barley 0.087 2 NS 0.17 1

Corn 0.087 2 7 0.17 1

Dried shelled beans (except 

soybean) 0.087 2 21 0.17 1

Edible podded legume vegetables 0.087 2 7 0.17 1

Fruiting vegetables 0.087 3 7 0.26 1

Oat 0.087 2 NS 0.17 1

Oilseed crops, canola/rapeseed 0.087 2 14 0.17 1

Oilseed crops, other 0.087 2 7 0.17 1

Peanut 0.087 3 14 0.26 2

Rye 0.087 2 NS 0.17 1

Soybean 0.087 2 7 0.17 1

Succulent shelled peas and beans 0.087 2 7 0.17 1

Sugar beet 0.087 3 14 0.26 2

Tuberous and corm vegetables 0.087 3 7 0.26 2

Wheat, triticale 0.087 2 NS 0.17 1

NS - not specified. NA - not applicable

Notes

1. Only 2 consecutive applications before alternating to a labeled fungicide w/ different mode of action.

2. Only 1 application before alternating to a labeled fungicide w/ different mode of action.

3. Max single use rate based on label footnote in Table 2.

4. Seeding rates obtained from USEPA model TREX Version 1.4.1 (http://www.epa.gov/oppefed1/models/terrestrial/index.htm#trex).
16

Appendix B

TIER I SURFACE WATER MODELING OUTPUT FILES

FIRST Output

 RUN No. 1 FOR fluxapyroxad ON beans * INPUT VALUES * 

 --------------------------------------------------------------------

 RATE (#/AC) No.APPS & SOIL SOLUBIL APPL TYPE %CROPPED INCORP

 ONE(MULT) INTERVAL Koc (PPM ) (%DRIFT) AREA (IN)

 --------------------------------------------------------------------

 0.180( 0.359) 2 7 931.0 3.4 AERIAL(16.0) 87.0 0.0

 FIELD AND RESERVOIR HALFLIFE VALUES (DAYS) 

 --------------------------------------------------------------------

 METABOLIC DAYS UNTIL HYDROLYSIS PHOTOLYSIS METABOLIC COMBINED

 (FIELD) RAIN/RUNOFF (RESERVOIR) (RES.-EFF) (RESER.) (RESER.) 

 --------------------------------------------------------------------

 857.00 2 0.00 0.00- 0.00 993.00 993.00

 UNTREATED WATER CONC (MICROGRAMS/LITER (PPB)) Ver 1.1.1 MAR 26, 2008

 --------------------------------------------------------------------

 PEAK DAY (ACUTE) ANNUAL AVERAGE (CHRONIC) 

 CONCENTRATION CONCENTRATION 

 --------------------------------------------------------------------

 14.064 6.699

 RUN No. 2 FOR fluxapyroxad ON seeds * INPUT VALUES * 

 --------------------------------------------------------------------

 RATE (#/AC) No.APPS & SOIL SOLUBIL APPL TYPE %CROPPED INCORP

 ONE(MULT) INTERVAL Koc (PPM ) (%DRIFT) AREA (IN)

 --------------------------------------------------------------------

 0.068( 0.068) 1 1 931.0 3.4 GRANUL( 0.0) 87.0 2.0

 FIELD AND RESERVOIR HALFLIFE VALUES (DAYS) 

 --------------------------------------------------------------------

 METABOLIC DAYS UNTIL HYDROLYSIS PHOTOLYSIS METABOLIC COMBINED

 (FIELD) RAIN/RUNOFF (RESERVOIR) (RES.-EFF) (RESER.) (RESER.) 

 --------------------------------------------------------------------

 857.00 2 N/A 0.00- 0.00 993.00 993.00

 UNTREATED WATER CONC (MICROGRAMS/LITER (PPB)) Ver 1.1.1 MAR 26, 2008

 --------------------------------------------------------------------

 PEAK DAY (ACUTE) ANNUAL AVERAGE (CHRONIC) 

 CONCENTRATION CONCENTRATION 

 --------------------------------------------------------------------

 1.222 0.545 
17

TIER I GROUND WATER MODELING OUTPUT FILES

SCI-GROW Output

 SCIGROW

 VERSION 2.3

 ENVIRONMENTAL FATE AND EFFECTS DIVISION

 OFFICE OF PESTICIDE PROGRAMS

 U.S. ENVIRONMENTAL PROTECTION AGENCY

 SCREENING MODEL

 FOR AQUATIC PESTICIDE EXPOSURE

SciGrow version 2.3

chemical:fluxapyroxad

time is 8/ 1/2011 8:46:30

------------------------------------------------------------------------

 Application Number of Total Use Koc Soil Aerobic

 rate (lb/acre) applications (lb/acre/yr) (ml/g) metabolism (days)

------------------------------------------------------------------------

 0.180 2.0 0.360 9.02E+02 366.0

------------------------------------------------------------------------

groundwater screening cond (ppb) = 8.74E-02 

************************************************************************

SciGrow version 2.3

chemical:fluxapyroxad

time is 8/ 1/2011 8:46:42

------------------------------------------------------------------------

 Application Number of Total Use Koc Soil Aerobic

 rate (lb/acre) applications (lb/acre/yr) (ml/g) metabolism (days)

------------------------------------------------------------------------

 0.068 1.0 0.068 9.02E+02 366.0

------------------------------------------------------------------------

groundwater screening cond (ppb) = 1.65E-02 

************************************************************************
18

Appendix C. Summary of Maximum Degradate Amounts in Environmental Fate Studies of Fluxapyroxad

Degradate 1

Max. Degradate % of Applied (Time of Peak)

Hydrolysis Aqueous 

Photolysis

Soil

Photolysis Aerobic Soil Anaerobic Soil

Source MRID 48409101 47923513 47923690

47923684

47923688

NJ (loam) ID (sandy loam) IL (loam) WI (loamy sand)

M700F001 -- -- 2.8% (Day 15) 32.6% (Day 123) 5.7% (Day 362) -- -- 10.1% (Day 123)

M700F002 -- -- -- -- -- 4.6% (Day 242) -- --

M700F007 -- -- -- -- -- -- -- --

Unknowns -- 2.8% (Day 15) 3.2% (Day 2) -- 1.4% (Day 362) -- 4.8% (Day 368) --

Nonextracted 

residues -- -- 5.1% (Day 15) 28.5% (Day 368) 11.3% (Day 362) 17.5% (Day 242) 39.4% (Day 368) 38.3% (Day 123)

CO2-- -- 1.3% (Day 15) 0.88% (Day 368) 0.52% (Day 362) 5.25% (Day 368) 0.42% (Day 368) 0.4% (Day 123)

Degradate 1

Max. Degradate % of Applied (Time of Peak) Analyzed Degradates (ppm)4

Aerobic Soil Aerobic Aquatic Anaerobic Aquatic TFD TFD TFD

Source MRID

47923691

47923713 47923714 47923695 47923696 47923697

CA (sandy loam) GA (sandy loam) IN (loam) NC (sandy loam)

M700F001 0.1% (Day 15) 0.7% (Day 15) 0.1% (Day 28) -- 10.9% (Day 43) 25.2% (Day 182) 0.003 

(Day 7)

0.006 

(Day 30)

0.026 

(Day 60)

M700F002 1.1% (Day 120) 0.4% (Day 120) 2.3% (Day 91) -- 3.7% (Day 100) 2.5% (Day 365) 0.003 

(Day 58)

0.004 (Day 

60)

0.009 

(Day 60)

M700F007 -- -- -- -- 7.5% (Day 57)2

-- NA5 NA NA

Unknowns 1.6% (Day 0) 1.2% (Day 0) 1.6% (Day 28) 1.2% (Day 15) 2% (Day 30) 14.8% (Day 365)3

Nonextracted 

residues 10.5% (Day 120) 24.9% (Day 120) 15.6% (Day 120) 25.6% (Day 120) 21.1% (Day 57) 15.8% (Day 365)

CO2 0.3% (Day 120) 0.4% (Day 120) 1.5% (Day 120) 0.5% (Day 120) 2.8% (Day 57) 2.8% (Day 365)

1. M700F001: 3-(difluoro-methyl)-1-methyl-1H-pyrazole-4-carboxylic acid

M700F002: 3-(difluoro-methyl)-1H-pyrazole-4-carboxylic acid

M700F007: 3-(difluoro-methyl)-1-methyl-1H-pyrazole-4-carboxamide

2. Formation occurred only under irradiated conditions. Under dark conditions, M700F001 and M700F007 did not form.

3. Unknowns contain multiple components, each accounting for <5% total applied residues.

4. Highest concentrations occurred in top 3 inches of soil.

5. NA – not analyzed