# Testing of Certain High Production Volume

Chemicals ; Third Group of Chemicals ( Exposure Findings Supporting Information )

U.S. Environmental Protection Agency Office of Pollution Prevention and Toxics Econo mics, Exposure and Technology Division

December 2009

### i 

# Table of Contents PREFACE 1.0 D ATA 

### S OURCE 

### D ESCRIPTIONS 

### ................................ ................................ .................. 3 2.0 S UMMARY OF 

### H PV3 C HEMICALS AND 

### F IN DI NGS 

### ................................ ..................... 4

### ii 

# P reface This findings document was prepared to support EPA’s Proposed TSCA Section 4 Test Rule for Certain High Production Volume Chemicals ; Third Group of Chemicals . Prior to promulg ating a test rule under section 4 of the Toxic Substances Control Act (TSCA), 15 U.S.C. §§2601 et seq , EPA is required to make certain findings identified in section 4(a) of TSCA relating to the chemical’s risk and potential exposure, the sufficiency of data to allow EPA to determine the human health or environmental effects of the chemical, and the need to conduct testing. Under TSCA section 4(a)(1)(B), EPA must make the following findings to support a test rule based on concerns for exposure: (1) that a chemical substance is or will be produced in substantial quantities and that it enters or may reasonabl y be anticipated to enter the environment in substantial quantities and/or that there is or may be substantial and/or significant human exposure to suc h substance; (2) that there are insufficient data and experience upon which the effects of the manufacture, distribution in commerce, processing, use or disposal of such substance or mixture or of an y combination of such activities on health or the environment can reasonabl y be determined or predicted; and (3) that testing of the substance or mixture with respect to such effects is necessary to develop such data. The criteria and standards used by EPA for evaluating the terms “substantial production,” “sub stantial release,” and “substantial or significant human exposure” as used in TSCA section 4(a)(1)(B)(i) are explained in EPA’s Final Statement of Policy ; Criteria for Evaluating Substantial Production, Substantial Release, and Substantial or Significant Human Exposure set forth at 58 FR 28736 (May 14, 1993) (hereinafter referred to as the “B Policy”).

This document provides a detailed discussion of EPA’s evaluation of each of the chemical substances identified in the proposed test rule to determine that preliminary TSCA section 4(a)(1)(B) findings concerning “substantial production,” “substantial release,” and “substantial or significant human exposure” can be made.

### 3

1.0 D ATA 

### S OURCE 

### D ESCRIPTIONS 

### TSCA Inventory Update Reporting Rule : In 1986, EPA promulgated the Inventory Update Reporting (IUR) regulations, under TSCA section 8(a), to facilitate the periodic updating of the TSCA Inventory

database and to otherwise support activities associated with implementing TSCA. As originally

promulgated, the IUR required chemical manufacturers (including importers) to report to EPA every 4 years the identity of chemical substances manufactured (including imported) annually in quantities of 10,000 pounds or more at each plant site they owned or controlled. In 2003 EPA adjus ted the universe of chemicals and plant sites that are required to report, and the type of information reported. In 2005, EPA changed the reporting frequency to once every 5 years, revised the manner in which amounts of a chemical substance manufactured or imported must be reported, and changed the submission period for reporting after 2006. 

### To protect the claims of confidential business information (CBI) asserted by some IUR submitters on the amount of the chemical substance manufactured (including import ed) at a specific site, all production volumes reported b y IUR submitters (i.e., CBI and non - CBI) for each chemical are combined by EPA for an aggregate total. Confidential business information claims are further protected b y using eight ranges to identif y the total for an y specific chemical and then making available to the public the range that corresponds to the aggregate production volume. Publicly - available information from the 1986, 1990, 1994, 1998, and 2002 (and 2006) IUR reporting cycles are availa ble on - line at: http://www.epa.gov/oppt/iur/index.htm The Toxics Release Inventory (TRI) contains information about releases of certain chemicals and management of wastes at a wide variety of sources, in cluding manufacturing operations, certain service businesses, and federal facilities. Publicly - available information from the 2005 TRIreporting cycle is available on - line at: http://www.epa.gov/triexplorer/ The National Institute for Occupational Safety and Health (NIOSH) conducted the National Occupational Exposure Survey (NOES) that collected data on potential occupational exposures to chemical, phy sical, and biological agents from 1981 to 1983. The survey involved on - site visits to 4,490 establishments in 522 industry t ypes employing approximately 1,800,000 workers in 377 occupational categories. Publicly - available information from the NOES is available on - line at: http://www.cdc.gov/noes/default.html The National Library of Medicine Household Products Database provides information on the chemical ingredients and their percentage in specific brands of household products. Information in the database is from a variety of publicl y available sources including brand - specific labels and Material Safety Data Sheets when available from manufacturers and manufacturers' web sites. Publicly - available information from the database is available on - line at: http://householdproducts.nlm.nih.gov/

### 4 2.0 S UMMARY OF 

### HPV3 C HEMICALS AND 

### F INDINGS



### Table 2 - 1 below presents a summary of the high production volume (HPV) chemicals (29) and data collected to support an exposure - based f inding. Table 2 - 2 presents a chemical by - chemical explanation of the supporting findings information. Table 2 - 3 presents the chemicals (16) that did not have sufficient exposure data needed to be included in this proposed rule. Table 2 - 1 Summary of Data S e arched for Exposure Based Findings

CAS# Chemical Name 2006 IUR Production Volume [Million lbs] PAIR

Production Volume [Million lbs] 2006 IUR

- Substantial Human Exposure (>1,000 Work ers) Met PAIR -

Substantial Human Exposure (>1,000 Work ers) Met NOES

Nu mber of Work ers NLM Household Chemicals Database Non - CBI

2006 IUR Commercial/ Consumer Code Description PAIR -

Substantial Human Exposure (Consumer Use Indicated) PAIR -

Substantial Release Criteria (>1 million lbs) Met 2005

TRI Data (Total On - and Off - si te Disposal or Other Releases, lbs) Meet Exposure Based Criteria for Work ers Meet Exposure Based Criteria for Consumers Meet

Exposure Based Criteria for Release 1 83 - 41 - 0 2 -Nitrobenzene, 1,2 - dimethyl - < 1 > 10 - 50 Yes Yes 2 96 - 22 - 0 3 - Pentanone > 10 - 50 > 10 - 50 Yes Yes 3 98 - 09 - 9 Benzenesulfonyl chloride > 1 - 10 > 1 - 10 851 C16 - Rubber and plastic products Yes Yes 4 98 - 56 - 6 Benzene, 1 - chloro - 4 - (trifluoromethyl) - > 1 - 10 > 1 - 10 1 home maintenance product Code(s)

claimed CBI Yes Yes 5 111 - 44 - 4 Ethane, 1,1' - oxybis[2 - chloro - > 1 - 10 < 1 C20 - Other; Code(s) claimed CBI 412 Yes Yes 6 127 - 68 - 4 Benzenesulfonic acid, 3 - nitro - , sodium salt (1:1) > 1 - 10 < 1 9,386 Yes 7 506 - 51 - 4 1 - Tetracosanol < 1 > 1 - 10 1,281 Yes 1 8 506 - 52 - 5 1 - Hexacosanol < 1 > 1 - 10 1,565 Yes 9 515 - 40 - 2 Benzene, (2 - chloro - 1,1 - dimethylethyl) - > 1 - 10 > 1 - 10 C02 - Agricultural products (non pesticidal) Yes Yes 1 0 2494 - 89 - 5 Ethanol, 2 - [(4 - aminophenyl)sul fonyl] - , 1 - (hydrogen sulfate) > 1 - 10 > 1 - 10 Code(s) claimed CBI Yes Yes 1 1 5026 - 74 - 4 2 - Oxiranemethanamine, N - [4 - (2 - oxiranylmethoxy)phenyl] -N - (2 - oxiranylmethyl) - > 1 - 10 > 1 - 10 Yes 952 Yes

### Table 2 - 1 (Continued)

5 CAS# Chemical Name 2006 IUR Production Volume [Million lbs] PAIR

Production Volume [Million lbs] 2006 IUR

- Substantial Human Exposure (>1,000 Work ers) Met PAIR -

Substantial Human Exposure (>1,000 Work ers) Met NOES

Nu mber of Work ers NLM Household Chemicals Database Non - CBI

2006 IUR Commercial/ Consumer Code Description PAIR -

Substantial Human Exposure (Consumer Use Indicated) PAIR -

Substantial Release Criteria (>1 million lbs) Met 2005

TRI Data (Total On - and Off - si te Disposal or Other Releases, lbs) Meet Exposure Based Criteria for Work ers Meet Exposure Based Criteria for Consumers Meet

Exposure Based Criteria for Release 1 2 22527 - 63 - 5 Propanoic acid, 2 - methyl - , 3 - (benzoyloxy) - 2,2,4 - trimethylpentyl ester > 1 - 10 > 1 - 10 C16 - Rubber and plastic products; Code(s) claimed CBI Yes Yes Yes 1 3 24615 - 84 - 7 2 - Propenoic acid, 2 - carboxyethyl ester > 1 - 10 < 1 C20 - Other Yes Yes 1 4 25321 - 41 - 9 Benzenesulfoni c acid, dimethyl - > 1 - 10 < 1 2,843 Yes 1 5 25646 - 71 - 3 Methanesulfonamide, N - [2 - [(4 - amino - 3 - methylphenyl)ethylamino]ethyl] - , sulfate (2:3) > 1 - 10 < 1 Yes C14 - Photographic supplies Yes Yes 1 6 52556 - 42 - 0 1 - Propanesulfonic acid, 2 - hydroxy- 3 - (2 - propen - 1 - yloxy) - , sodium salt (1:1) > 1 - 10 > 1 - 10 Yes C20 - Other Yes Yes 17 61788 - 76 - 9 Alkanes, chloro > 10 - 50 > 1 - 10 176,314 C01 - Adhesives and sealants; C20 - Other Yes Yes 18 65996 - 79 - 4 Solvent naphtha (coal) > 10 - 50 > 10 - 50 C20 - Other Yes Yes 19 65996 - 82 - 9 Tar oils, coal > 100 million - 1 billion > 100 million

- 1 billion C16 - Rubber and plastic products; C19 - Wood and wood furniture; C20 - Other Yes Yes

20 65996 - 89 - 6 Tar, coal, high - temp. > 1 billion lbs > 1 billion

lbs Yes 761 C12 - Paints and coatings; C20 - Other Yes Yes Yes Yes Yes

2 1 65996 - 92 - 1 Distillates (coal tar) > 100 million - 1 billion > 100 million

- 1 billion C16 - Rubber and plastic products; C19 - Wood and wood furniture; C20 - Other Yes Y es 2 2 68082 - 78 - 0 La rd, oil, Me esters > 1 - 10 > 1 - 10 41,153 Yes

### Table 2 - 1 (Continued)

6 CAS# Chemical Name 2006 IUR Production Volume [Million lbs] PAIR

Production Volume [Million lbs] 2006 IUR

- Substantial Human Exposure (>1,000 Work ers) Met PAIR -

Substantial Human Exposure (>1,000 Work ers) Met NOES

Nu mber of Work ers NLM Household Chemicals Database Non - CBI

2006 IUR Commercial/ Consumer Code Description PAIR -

Substantial Human Exposure (Consumer Use Indicated) PAIR -

Substantial Release Criteria (>1 million lbs) Met 2005

TRI Data (Total On - and Off - si te Disposal or Other Releases, lbs) Meet Exposure Based Criteria for Work ers Meet Exposure Based Criteria for Consumers Meet

Exposure Based Criteria for Release 2 3 68187 - 57 - 5 Pitch, coal tar - petroleum > 100 million - 1 billion > 100 million

- 1 billion C11 - Metal products Yes Yes 2 4 68442 - 60 - 4 Acetaldehyde, reaction products with formaldehyde, by- products from > 1 - 10 > 1 - 10 Code(s) claimed CBI Yes Yes Yes 25 68610 - 90 - 2 2 - Butenedioic acid (2E) - , di - C8 - 18 - alkyl esters > 1 - 10 > 1 - 10 Yes Yes 26 68988 - 22 - 7 1,4 - Benzenedicarboxylic acid, 1,4 - dimethyl ester, m anuf. of, by- products from > 10 - 50 > 10 - 50 Yes Yes 27 70693 - 50 - 4 Phenol, 2,4 -bis(1 - methyl - 1 - phenylethyl) - 6 - [2 - (2 - nitrophenyl)diazenyl] - > 1 - 10 > 1 - 10 Code(s) claimed CBI Yes Yes 28 72162 - 15 - 3 1 - Decene, sulfurized > 1 - 10 < 1 64,227 Yes 29 73665 - 18 - 6 Extract residues (coal), tar oil alk., naphthalene distn. residues > 50 - 100 > 100 million

- 1 billion C19 - Wood and wood furniture Yes Yes

### 7 Table 2 - 2 Chemical - by - Chemical Explanation of Findings CAS# Chemica l Name Summary of Findings 83 - 41 - 0 2 -N itrobenzene , 1,2 - d imethyl PAIR indicates >1 million lbs of this chemical is released to the environment. Based on this information, this chemical would meet the exposure based findings criteria of “significant or su bstantial release.” This chemical met exposure based findings criteria based on:

- PAIR Production Volume Range (10 million - 5 0 million lb)

- Substantial Release (Greater than 1 million lbs released) 96 - 22 - 0 3 - Pentanone PAIR indicates consumer use . I t is possible that products containing this chemical may be used by >10,000 consumers. Based on this information, this chemical would meet the exposure based findings criteria of "substantial or significant human exposure.” This chemical met exposure bas ed findings criteria based on:

- 2006 IUR Production Volume Range (1 0 mi llion - 5 0 million lb)

- Consumers potentially exceeding 10,000 people

98 - 09 - 9 Benzenesulfonyl chloride The IUR commercial/consumer product category C16 - Rubber and plastic products wa s reported for this chemical. Chemicals reporting in this category are contained in such products as tires, footwear, flooring, bottles, sporting equipment, games, and toys. It is expected that these products will be widely used by consumers (including chi ldren) and hence, may likely exceed 10,000 people. Additionally, products such as tires and flooring are also used in a commercial setting, which may lead to exposures of >1,000 commercial workers. Based on this information, this chemical would meet the exposure based findings criteria of "substantial or significant human exposure.” (All stated IUR commercial/consumer product categories are non - CBI) This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 mill ion - 10 million lb)

- Total workers potentially exceeding 1,000 based on the IUR commercial/consumer product categories (C16 )

- Consumers potentially exceeding 10,000 people based on IUR commercial/consumer product category (C16)

### Table 2 - 2 (Continued)

8 CAS# Chemica l Name Summary of Findings 98 - 56 - 6 Benzene, 1 - ch loro - 4 - (trifluoromethyl) - The number of potentially exposed consumers is estimated to be very large based on the use (home maintenance product) cited in the NLM Household Chemicals Database. It is expected that home maintenance products will be widely use d by

consumers and hence, may likely exceed 10,000 people. Based on this information, this chemical wo uld meet the exposure based findings criteria of "substantial or significant human exposure.” This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Consumers potentially exceeding 10,000 people based on NLM Household Chemicals Database

111 - 44 - 4 Ethane, 1,1' - oxybis[2 - chloro The IUR commercial/consumer product category C20 - Other ( ch emicals contained in commercial and consumer products not elsewhere classified ) was reported for this chemical. This indicates that this chemical is present in an unknown number of commercial and consumer products that may potentially have a high number of exposures. Based on this information, this chemical would meet the exposure based findings criteria of "substantial or significant human exposure.” (All stated IUR commercial/consumer product categories are non - CBI) This chemical met exposure based fin dings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers potentially exceeding 1,000 based on IUR commercial/consumer product category (C20)

- Consumers potentially exceeding 10,000 people based on IUR commer cial/consumer product category (C20)

127 - 68 - 4 Benzenesulfonic acid, 3 - nitro - , sodium

salt (1:1) The number of potentially exposed total workers exceeds 1,000 based on NOES data. The production volume data for the 2006 IUR data collection was com pared to the production volume data for the 1986 IUR data collection for this chemical to see if the production volume stayed the same or increased, thereby indicating that the usage of these chemicals is no less than when NOES data were gathered . The 1986 reporte d IUR production volume range was 1 million - 10 million lbs. The 2006 IUR production volume range is 1 million - 10 million lbs . This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- T otal workers exceeding 1,000 based NOES data (9,386 workers)

506 - 51 - 4 1 - Tetracosanol The number of potentially exposed total workers exceeds 1,000 based on NOES data. The production volume data for the PAIR data collection was compared to the production volume data for the 1986 IUR data collection for this chemical to see if the production volume stayed the same or increased, thereby indicating that the usage of these chemicals is no less than when NOES data were gathered . The 1986 reported IUR productio n volume range was 1 million - 10 million lbs. The PAIR production volume range is 1 million - 10 million lbs . This chemical met exposure based findings criteria based on:

- PAIR Production Volume Range (1 million - 10 million lb)

- Total workers exceeding 1,000 based NOES data (1,281 workers)

### Table 2 - 2 (Continued)

9 CAS# Chemica l Name Summary of Findings

506 - 52 - 5 1 - Hexacosanol The number of potentially exposed total workers exceeds 1,000 based on NOES data. The production volume data for the PAIR data collection was compared to the production volume data for the 1986 IUR data collection for this chemical to see if the production volume stayed the same or increased, thereby indicating that the usage of these chemicals is no less than when NOES data were gathered . The 1986 reported IUR production volume range was 1 mil lion - 10 million lbs. The PAIR production volume range is 1 million - 10 million lbs . This chemical met exposure based findings criteria based on:

- PAIR Production Volume Range (1 million - 10 million lb)

- Total workers exceeding 1,000 based NOES data (1 ,565 workers)

515 - 40 - 2 Benzene, (2 - chloro - 1,1 - dimethylethyl) - The IUR commercial/consumer product category C02 - Agricultural products (non - pesticidal) was reported for this chemical. Chemicals reporting in this category are used to increase the productivi ty and quality of farm crops; examples include fertilizers and soil conditioners. It is expected that these products will be widely used by commercial workers and consumers and hence, may likely exceed 1,000 commercial workers and 10,000 consumers. Based on this information, this chemical would meet the exposure based findings criteria of "substantial or significant human exposure.” (All stated IUR commercial/consumer product categories are non - CBI) This chemical met exposure based findings criteria b ased on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers potentially exceeding 1,000 based on the IUR commercial/consumer product categories (C02 )

- Consumers potentially exceeding 10,000 people based on IUR commercial/con sumer product category (C02)

2494 - 89 - 5 Ethanol, 2 - [(4 - aminophenyl)sulfonyl] - ,

1 - (hydrogen sulfate) The IUR commercial/consumer product category(s) was claimed CBI for this chemical. This chemical is present in an unknown number of commercial and consumer products that may potentially have a high number of exposures. Based on this information, this chemical would meet the exposure based findings criteria of "substantial or significant human exposure.” This chemical met exposure based findings criteria ba sed on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers potentially exceeding 1,000 based on IUR commercial/consumer product category(s) claimed CBI

- Consumers potentially exceeding 10,000 people based on IUR commercial/con sumer product category claimed CBI 5026 - 74 - 4 2 - Oxiranemethanamine, N - [4 - (2 -

oxiranylmethoxy)phenyl] - N - (2 - oxiranylmethyl) - The total number of potentially exposed workers is likely to exceed 1,000 based on reported IUR data. This chemical met exposure ba sed findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers potentially exceeding 1,000 based on IUR data

### Table 2 - 2 (Continued)

10 CAS# Chemica l Name Summary of Findings

22527 - 63 - 5 Propanoic acid, 2 - me thyl - , 3 -

(benzoyloxy) - 2,2,4 - trimethylpentyl ester The IUR commerci al/consumer product category C16 - Rubber and plastic products was reported for this chemical. Chemicals reporting in this category are contained in such products as tires, footwear, flooring, bottles, sporting equipment, games, and toys. It is expected that these products will be widely used by consumers (including children) and hence, may likely exceed 10,000 people. Additionally, products such as tires and flooring are also used in a commercial setting, which may lead to exposures of >1,000 commercial workers. Other product category(s) was claimed CBI. Based on this information, this chemical would meet the exposure based findings criteria of "substantial or significant human exposure.” (All stated IUR commercial/consumer product categories are non - CBI ) This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers potentially exceeding 1,000 based on the IUR commercial/consumer product categories (C16 )

- Consumers potenti ally exceeding 10,000 people based on IUR commercial/consumer product category (C16)

24615 - 84 - 7 2 - Propenoic acid, 2 - carboxyethyl ester The IUR commercial/consumer product category C20 - Other ( chemicals contained in commercial and consumer products not else where classified ) was reported for this chemical. This indicates that this chemical is present in an unknown number of commercial and consumer products that may potentially have a high number of exposures. Based on this information, this chemical would mee t the exposure based findings criteria of "substantial or significant human exposure.” (All stated IUR commercial/consumer product categories are non - CBI) This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers potent ially exceeding 1,000 based on I UR commercial/consumer product category (C20)

- Consumers potentially exceeding 10,000 people based on IUR commercial/consumer product category (C20)

25321 - 41 - 9 Benzenesulfoni c acid, dimethyl The total number of potentially exposed workers exceeds 1,000 workers based on NOES data. The production volume data for the 2006 IUR data collection was com pared to the production volume data for the 1986 IUR data collection for this che mical to see if the production volume stayed the same or increased, thereby indicating that the usage of these chemicals is no less than when NOES data were gathered . The 1986 reported IUR production volume range was 1 million - 10 million lbs. The 2006 I UR production volume range is 1 million - 10 million lbs. This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers exceeding 1,000 based NOES data (2,843 workers)

### Table 2 - 2 (Continued)

11 CAS# Chemica l Name Summary of Findings

25646 - 71 - 3 Methanesulfonamide, N - [2 - [(4 - amino 3 - methylphenyl)ethylamino]ethyl] - , sulfate (2:3) The total number of potentially exposed workers is likely to exceed 1,000 based on reported IUR data. Additionally, the IUR commercial/consumer product category C14 - Pho tographic supplies was reported for this chemical. Chemicals reporting in this category are contained in photographic apparatus, equipment and parts; film, paper, plates, and prepared photographic chemicals for commercial and consumer use. It is expected that these products will be widely used by commercial workers and consumers and hence, may likely exceed 1,000 commercial workers and 10,000 consumers. Based on this information, this chemical would meet the exposure based findings criteria of "substanti al or significant human exposure.” (All stated IUR commercial/consumer product categories are non - CBI) This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers potentiall y exceeding 1,000 based on IUR data and commercial/consumer product category (C14)

- Consumers potentially exceeding 10,000 people based on IUR commercial/consumer product category (C14)

52556 - 42 - 0 1 - Propanesulfonic acid, 2 - hydroxy - 3 -

(2 - propen - 1 - yloxy) - , sodium salt (1:1) The IUR commercial/consumer product category C20 - Other ( chemicals contained in commercial and consumer products not elsewhere classified ) was reported for this chemical. This indicates that this chemical is present in an unknown number of commercial and consumer products that may potentially have a high number of exposures. Based on this information, this chemical would meet the exposure based findings criteria of "substantial or significant human exposure.” (All stated IUR commercial/co nsumer product categories are non - CBI) This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers potentially exceeding 1,000 based on IUR commercial/consumer product catego ry (C20)

- Consumers potentially exceeding 10,000 people based on IUR commercial/consumer product category (C20)

### Table 2 - 2 (Continued)

12 CAS# Chemica l Name Summary of Findings

61788 - 76 - 9 Alkanes, chloro The total number of potentially exposed workers exceeds 1,000 workers based on NOES data. Additionally, the number of potentially exposed consumers is estimated to be very large based on the reported IUR commercial/consumer product categories for this chemical: C01 - Adhesives and sealants , and C20 - Other ( chemicals contained in commercial and consumer products not elsewh ere classified ). Chemicals reporting in these product categories are contained in industrial and household adhesives, glues, caulking compounds, and sealants, along with an unknown number of commercial and consumer products that may potentially have a high num ber of exposures. It is expected that these products will be widely used by commercial workers and consumers and hence, may likely exceed 1,000 commercial workers and 10,000 consumers. Based on this information, this chemical would meet the exposure based findings criteria of "substantial or significant human exposure.” The production volume data for the 2006 IUR data collection was compared to the production volume data for the 1986 IUR data collection for this chemical to see if the production volum e stayed the same or increased, thereby indicating that the usage of these chemicals is no less than when NOES data were gathered . The 1986 reported IUR production volume range was 1 million - 10 million lbs. The 2006 IUR production volume range is 10 mill ion - 50 million lbs . (All stated IUR commercial/consumer product categories are non - CBI) This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (10 million - 50 million lb)

- Total workers exceeding 1,000 based N OES data (176,314 workers)

- Total workers potentially exceeding 1,000 based on IUR commercial/consumer product categories ( C01, C20)

- Consumers potentially exceeding 10,000 people based on IUR commercial/consumer product category (C01, C20)

65996 - 79 - 4 Solvent naphtha (coal) The IUR commercial/consumer product category C20 - Other ( chemicals contained in commercial and consumer products not elsewhere classified ) was reported for this chemical. This indicates that this chemical is present in an unknown numb er of commercial and consumer products that may potentially have a high number of exposures. Based on this information, this chemical would meet the exposure based findings criteria of "substantial or significant human exposure.” (All stated IUR commerci al/consumer product categories are non - CBI) This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (10 million - 50 million lb)

- Total workers potentially exceeding 1,000 based on IUR commercial/consumer product category (C20)

- Consumers potentially exceeding 10,000 people based on IUR commercial/consumer product category (C20)

### Table 2 - 2 (Continued)

13 CAS# Chemica l Name Summary of Findings

65996 - 82 - 9 Tar oils, coal The IUR commercial/consumer product categories C16 - Rubber and plastic products, C19 - Wood and wood furniture, and C20 - Other ( chemicals contained in commercial and consumer products not elsewhere classified ) were reported for this chemical. Chemicals reporting in these product categories are contained in tires, footwear, flooring, bottles, sporting equipment, games, toys, wood products and wood furniture, along with an unknown number of commercial and consumer products that may potentially have a high number of exposures. It is expected that these products will be widely used by commercial workers and consumers and hence, may likely exceed 1,000 commercial workers and 10,000 consumers. Based on this information, this chemical would meet the exposure based findings criteria of "substantial or significant human exposure.” (All stated IUR commercial/consumer product categories are non - CBI) This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (100 million - 1 billion lb)

- Total workers potentially exceeding 1,000 based on IUR commercial/consumer product categories (C16, C19, C20)

- Consumers potentially exceeding 10,000 people based on IUR commercial/consumer product category (C16,C19,C20)

65996 - 89 - 6 Tar, coal, high - tem p. The total number of potentially exposed workers is likely to exceed 1,000 based on reported PAIR data.

Additionally, the number of potentially exposed consumers is estimated to be very large based on the reported IUR commercial/consumer product categories for this chemical: C12 - Paints and coatings, and C20 - Other ( chemicals contained in commercial and consum er products not elsewhere classified ). Chemicals reporting in these product categories are commercial and consumer paints (paste or ready - mix) including artists’ paints, varnishes, lacquers, enamels and shellac, paint and varnish removers and cleaners, alo ng with an unknown number of commercial and consumer products that may potentially have a high number of exposures. It is expected that these products will be widely used by commercial workers and consumers and hence, may likely exceed 1,000 commercial wo rkers and 10,000 consumers. PAIR indicates >1 million lbs of this chemical is released to the environment. Based on this information, this chemical would meet the exposure based findings criteria of "substantial or significant human exposure" and “signif

icant or substantial release.” (All stated IUR commercial/consumer product categories are non - CBI) This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (> 1 billion lb)

- Total workers potentially exceeding 1,0 00 based on PAIR data

- Total workers potentially exceeding 1,000 based on the IUR commercial/consumer product categories (C12, C20 )

- Consumers potentially exceeding 10,000 people based on IUR commercial/consumer product category (C12,C20)

- Substantial Release (Greater than 1 million lbs released)

### Table 2 - 2 (Continued)

14 CAS# Chemica l Name Summary of Findings

65996 - 92 - 1 Distillates (coal tar) The IUR commercial/consumer product categories C16 - Rubber and plastic products, C19 - Wood and wood furniture, and C20 - Other ( chemicals contained in commercial and consumer pro ducts not elsewhere classified ) were reported for this chemical. Chemicals reporting in these product categories are contained in tires, footwear, flooring, bottles, sporting equipment, games, toys, wood products and wood furniture, along with an unknown number of commercial and consumer products that may potentially have a high number of exposures. It is expected that these products will be widely used by commercial workers and consumers and hence, may likely exceed 1,000 commercial workers and 10,000 con sumers. Based on this information, this chemical would meet the exposure based findings criteria of "substantial or significant human exposure.” (All stated IUR commercial/consumer product categories are non - CBI) This chemical met exposure based findin gs criteria based on:

- 2006 IUR Production Volume Range (100 million - 1 billion lb)

- Total workers potentially exceeding 1,000 based on IUR commercial/consumer product categories (C16, C19, C20)

- Consumers potentially exceeding 10,000 people based on I UR commercial/consumer product category (C16,C19, C20)

68082 - 78 - 0 Lard, oil, Me esters The total number of potentially exposed workers exceeds 1,000 workers based on NOES data. The production volume data for the 2006 IUR data collection was com pared to th e production volume data for the 1986 IUR data collection for this chemical to see if the production volume stayed the same or increased, thereby indicating that the usage of these chemicals is no less than when NOES data were gathered . The 1986 reported IUR production volume range was 500 thousand - 1 million lbs. The 2006 IUR production volume range is 1 million - 10 million lbs . This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers exceeding 1,000 based NOES data (41,153 workers)

68187 - 57 - 5 Pitch, coal tar - petroleum The IUR commercial/consumer product category C11 - Metal products was reported for this chemical. Chemicals reporting in this category are contained in metal products for commercial and consumer use; metal furniture and furnishings are included in this category. It is expected that these products will be widely used by commercial workers and consumers (including children) and hence, may likely exceed 1, 000 commercial workers and 10,000 consumers. Based on this information, this chemical would meet the exposure based findings criteria of "substantial or significant human exposure.” (All stated IUR commercial/consumer product categories are non - CBI) Th is chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (100 million - 1 billion lb)

- Total workers potentially exceeding 1,000 based on IUR commercial/consumer product category (C11)

- Consumers potentially exceeding 10,000 people based on IUR commercial/consumer product category (C11)

### Table 2 - 2 (Continued)

15 CAS# Chemica l Name Summary of Findings

68442 - 60 - 4 Acetaldehyde, reaction products with

formaldehyde, by - products from The IUR commercial/consumer product category(s) was claimed CBI for this chemical. This chemical is prese nt in an unknown number of commercial and consumer products that may potentially have a high number of exposures. Additionally, PAIR indicates consumer use . I t is possible that products containing this chemical may be used by >10,000 consumers. Based on this information, this chemical would meet the exposure based findings criteria of "substantial or significant human exposure.” This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers potentially exceeding 1,000 based on IUR commercial/consumer product category(s) claimed CBI

- Consumers potentially exceeding 10,000 people based on IUR commercial/consumer product category claimed CBI 68609 - 05 - 2 Cyclohexane, oxidized Th is chemical met one exposure based findings criteri on :

- PAIR Production Volume Range (1 million - 10 million lb) 68610 - 90 - 2 2 - Butenedioic acid (2E) - , di - C8 - 18 -

alkyl esters PAIR indicates consumer use . I t is possible that products containing this chemical may be used by >10,000 consumers. Based on this information, this chemical would meet the exposure based findings criteria of "substantial or significant human exposure.” This chemical met exposure based findings criteria based on:

- 2006 IUR Producti on Volume Range (1 million - 10 million lb)

- Consumers potentially exceeding 10,000 people 68988 - 22 - 7 1,4 - Benzenedicarboxylic acid, 1,4 -

dimethyl ester, manuf. of, by - products from PAIR indicates >1 million lbs of this chemical is released to the environm ent. Based on this information, this chemical would meet the exposure based findings criteria of “significant or substantial release.” This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (10 million - 50 mill ion lb)

- Substantial Release (Greater than 1 million lbs released)

70693 - 50 - 4 Phenol, 2,4 - bis(1 - me thyl - 1 -

phenylethyl) - 6 - [2 - (2 - nitrophenyl)diazenyl] - The IUR commercial/consumer product category(s) was claimed CBI for this chemical. This chemical is prese nt in an unknown number of commercial and consumer products that may potentially have a high number of exposures. Based on this information, this chemical would meet the exposure based findings criteria of "substantial or significant human exposure.” Th is chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers potentially exceeding 1,000 based on IUR commercial/consumer product category(s) claimed CBI

- Consumers potentially exceeding 10,000 people based on IUR commercial/consumer product category claimed CBI

### Table 2 - 2 (Continued)

16 CAS# Chemica l Name Summary of Findings

72162 - 15 - 3 1 - Decene, sulfurized The total number of potentially exposed workers exceeds 1,000 workers based on NOES data. The production volume data for the 2006 IUR dat a collection was com pared to the production volume data for the 1986 IUR data collection for this chemical to see if the production volume stayed the same or increased, thereby indicating that the usage of these chemicals is no less than when NOES data wer e gathered . The 1986 reported IUR production volume range was 1 million - 10 million lbs. The 2006 IUR production volume range is 1 million - 10 million lbs . This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers exceeding 1,000 based NOES data (64,227 workers)

73665 - 18 - 6 Extract residues (coal), tar oil alk.,

naphthalene distn. residues The IUR commercial/consumer product category C19 - Wood and wood furniture was report ed for this chemical. Chemicals reporting in this category are contained in wood products and wood furniture for commercial and consumer use. It is expected that these products will be widely used by commercial workers and consumers (including children) and hence, may likely exceed 1,000 commercial workers and 10,000 consumers. Based on this information, this chemical would meet the exposure based findings criteria of "substantial or significant human exposure.” (All stated IUR commercial/consumer prod uct categories are non - CBI) This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (50 million - 100 million lb)

- Total workers potentially exceeding 1,000 based on the IUR commercial/consumer product categories (C19 )

- Consumers potentially exceeding 10,000 people based on IUR commercial/consumer product category (C19)

### Table 2 - 3 HPV Orphan Chemicals Not Included in Third Group of Chemicals CAS# Chemical Name 1 98 - 16 - 8 Benzenamine, 3 - (trifluor omethyl) - 2 124 - 63 - 0 Methanesulfonyl chloride 3 460 - 00 - 4 Benzene, 1 - bromo - 4 - fluoro 4 542 - 92 - 7 1,3 - Cyclopentadiene 5 928 - 72 - 3 Glycine, N - (carboxymethyl) - , sodium salt (1:2) 6 1738 - 25 - 6 Propanenitrile, 3 - (dimethylamino) - 7 28106 - 30 - 1 Benzene, ethenyle thyl 8 35203 - 06 - 6 Benzenamine, 2 - ethyl - 6 - methyl -N - methylene 9 35203 - 08 - 8 Benzenamine, 2,6 - diethyl - N - methylene 10 37734 - 45 - 5 Carbonochloridothioic acid, S - (phenylmethyl) ester 11 37764 - 25 - 3 Acetamide, 2,2 - dichloro -N,N - di - 2 - propen - 1 - yl 12 68609 - 05 - 2 Cyclohexane, oxidized 13 65996 - 91 - 0 Distillates (coal tar), upper 14 68153 - 60 - 6 Fatty acids, tall - oil, reaction products with diethylenetriamine, acetates 15 68442 - 77 - 3 2 - Butenediamide, (2E) - , N1,N4 - bis[2 - (4,5 - dihydro - 2 - nortall - oil alkyl - 1H - imidazol - 1 - yl)ethyl] derivs. 16 68909 - 77 - 3 Ethanol, 2,2' - oxybis - , reaction products with ammonia, morpholine derivs. residues