Testing of Certain High Production Volume 

Chemicals; Third Group of Chemicals

(Exposure Findings Supporting Information)

U.S. Environmental Protection Agency

Office of Pollution Prevention and Toxics 

Economics, Exposure and Technology Division 

December 2009
i

Table of Contents

PREFACE

1.0 DATA SOURCE DESCRIPTIONS.................................................................................. 3

2.0 SUMMARY OF HPV3 CHEMICALS AND FINDINGS..................................................... 4
ii

Preface

This findings document was prepared to support EPA’s Proposed TSCA Section 4 

Test Rule for Certain High Production Volume Chemicals; Third Group of Chemicals. Prior to 

promulgating a test rule under section 4 of the Toxic Substances Control Act (TSCA), 15 U.S.C. 

§§2601 et seq, EPA is required to make certain findings identified in section 4(a) of TSCA 

relating to the chemical’s risk and potential exposure, the sufficiency of data to allow EPA to 

determine the human health or environmental effects of the chemical, and the need to conduct 

testing.

Under TSCA section 4(a)(1)(B), EPA must make the following findings to 

support a test rule based on concerns for exposure: (1) that a chemical substance is or will be 

produced in substantial quantities and that it enters or may reasonably be anticipated to enter the 

environment in substantial quantities and/or that there is or may be substantial and/or significant 

human exposure to such substance; (2) that there are insufficient data and experience upon which 

the effects of the manufacture, distribution in commerce, processing, use or disposal of such 

substance or mixture or of any combination of such activities on health or the environment can 

reasonably be determined or predicted; and (3) that testing of the substance or mixture with 

respect to such effects is necessary to develop such data. The criteria and standards used by EPA 

for evaluating the terms “substantial production,” “substantial release,” and “substantial or 

significant human exposure” as used in TSCA section 4(a)(1)(B)(i) are explained in EPA’s Final 

Statement of Policy; Criteria for Evaluating Substantial Production, Substantial Release, and 

Substantial or Significant Human Exposure set forth at 58 FR 28736 (May 14, 1993) (hereinafter 

referred to as the “B Policy”).

This document provides a detailed discussion of EPA’s evaluation of each of the 

chemical substances identified in the proposed test rule to determine that preliminary TSCA 

section 4(a)(1)(B) findings concerning “substantial production,” “substantial release,” and 

“substantial or significant human exposure” can be made. 
3

1.0 DATA SOURCE DESCRIPTIONS

TSCA Inventory Update Reporting Rule: In 1986, EPA promulgated the Inventory Update 

Reporting (IUR) regulations, under TSCA section 8(a), to facilitate the periodic updating of the 

TSCA Inventory database and to otherwise support activities associated with implementing TSCA. 

As originally promulgated, the IUR required chemical manufacturers (including importers) to report 

to EPA every 4 years the identity of chemical substances manufactured (including imported) 

annually in quantities of 10,000 pounds or more at each plant site they owned or controlled. In 2003 

EPA adjusted the universe of chemicals and plant sites that are required to report, and the type of 

information reported. In 2005, EPA changed the reporting frequency to once every 5 years, revised 

the manner in which amounts of a chemical substance manufactured or imported must be reported, 

and changed the submission period for reporting after 2006.

To protect the claims of confidential business information (CBI) asserted by some IUR 

submitters on the amount of the chemical substance manufactured (including imported) at a 

specific site, all production volumes reported by IUR submitters (i.e., CBI and non-CBI) for each 

chemical are combined by EPA for an aggregate total. Confidential business information claims 

are further protected by using eight ranges to identify the total for any specific chemical and then 

making available to the public the range that corresponds to the aggregate production volume. 

Publicly-available information from the 1986, 1990, 1994, 1998, and 2002 (and 2006) IUR 

reporting cycles are available on-line at: http://www.epa.gov/oppt/iur/index.htm

The Toxics Release Inventory (TRI) contains information about releases of certain chemicals 

and management of wastes at a wide variety of sources, including manufacturing operations, 

certain service businesses, and federal facilities. Publicly-available information from the 2005 

TRI reporting cycle is available on-line at: http://www.epa.gov/triexplorer/

The National Institute for Occupational Safety and Health (NIOSH) conducted the National 

Occupational Exposure Survey (NOES) that collected data on potential occupational 

exposures to chemical, physical, and biological agents from 1981 to 1983. The survey involved 

on-site visits to 4,490 establishments in 522 industry types employing approximately 1,800,000 

workers in 377 occupational categories. Publicly-available information from the NOES is 

available on-line at: http://www.cdc.gov/noes/default.html

The National Library of Medicine Household Products Database provides information on the 

chemical ingredients and their percentage in specific brands of household products. Information 

in the database is from a variety of publicly available sources including brand-specific labels and 

Material Safety Data Sheets when available from manufacturers and manufacturers' web sites. 

Publicly-available information from the database is available on-line at: 

http://householdproducts.nlm.nih.gov/
4

2.0 SUMMARY OF HPV3 CHEMICALS AND FINDINGS

Table 2-1 below presents a summary of the high production volume (HPV) chemicals (29) and data collected to support an exposure-based finding. Table 2-2 presents a chemicalby-chemical explanation of the supporting findings information. Table 2-3 presents the chemicals (16) that did not have sufficient exposure data needed to be included in this proposed rule.

Table 2-1

Summary of Data Searched for Exposure Based Findings

CAS# Chemical Name

2006 IUR 

Production 

Volume

[Million 

lbs]

PAIR 

Production 

Volume

[Million lbs]

2006 IUR 

-

Substantial 

Human 

Exposure 

(>1,000 

Workers) 

Met

PAIR -

Substantial 

Human 

Exposure 

(>1,000 

Workers) 

Met

NOES 

Number of 

Workers

NLM 

Household 

Chemicals 

Database 

Non-CBI 

2006 IUR 

Commercial/ 

Consumer 

Code 

Description

PAIR -

Substantial 

Human 

Exposure 

(Consumer 

Use 

Indicated)

PAIR -

Substantial 

Release 

Criteria 

(>1 million 

lbs) Met 

2005 

TRI 

Data(Total 

On- and 

Off-site 

Disposal or 

Other 

Releases, 

lbs)

Meet 

Exposure 

Based 

Criteria

for 

Workers

Meet 

Exposure 

Based 

Criteria 

for 

Consumers

Meet 

Exposure 

Based 

Criteria 

for 

Release

1 83-41-0 2-Nitrobenzene, 1,2-dimethyl- < 1 > 10 - 50 Yes Yes

2 96-22-0 3-Pentanone > 10 - 50 > 10 - 50 Yes Yes

3 98-09-9 Benzenesulfonyl chloride > 1 - 10 > 1 - 10 851

C16-Rubber 

and plastic 

products

Yes Yes

4 98-56-6

Benzene, 1-chloro-4-

(trifluoromethyl)-

> 1 - 10 > 1 - 10

1 home 

maintenance 

product

Code(s) 

claimed CBI Yes Yes

5 111-44-4 Ethane, 1,1'-oxybis[2-chloro- > 1 - 10 < 1

C20-Other; 

Code(s) 

claimed CBI

412 Yes Yes

6 127-68-4

Benzenesulfonic acid, 3-nitro-, 

sodium salt (1:1) > 1 - 10 < 1 9,386 Yes

7 506-51-4 1-Tetracosanol < 1 > 1 - 10 1,281 Yes

18 506-52-5 1-Hexacosanol < 1 > 1 - 10 1,565 Yes

9 515-40-2

Benzene, (2-chloro-1,1-

dimethylethyl)-

> 1 - 10 > 1 - 10

C02-

Agricultural 

products 

(nonpesticidal)

Yes Yes

10 2494-89-5

Ethanol, 2-[(4-

aminophenyl)sulfonyl]-, 1-

(hydrogen sulfate)

> 1 - 10 > 1 - 10 Code(s) 

claimed CBI Yes Yes

11 5026-74-4

2-Oxiranemethanamine, N-[4-(2-

oxiranylmethoxy)phenyl]-N-(2-

oxiranylmethyl)-

> 1 - 10 > 1 - 10 Yes 952 Yes
Table 2-1 (Continued)

 

5

CAS# Chemical Name

2006 IUR 

Production 

Volume

[Million 

lbs]

PAIR 

Production 

Volume

[Million lbs]

2006 IUR 

-

Substantial 

Human 

Exposure 

(>1,000 

Workers) 

Met

PAIR -

Substantial 

Human 

Exposure 

(>1,000 

Workers) 

Met

NOES 

Number of 

Workers

NLM 

Household 

Chemicals 

Database 

Non-CBI 

2006 IUR 

Commercial/ 

Consumer 

Code 

Description

PAIR -

Substantial 

Human 

Exposure 

(Consumer 

Use 

Indicated)

PAIR -

Substantial 

Release 

Criteria 

(>1 million 

lbs) Met 

2005 

TRI 

Data(Total 

On- and 

Off-site 

Disposal or 

Other 

Releases, 

lbs)

Meet 

Exposure 

Based 

Criteria

for 

Workers

Meet 

Exposure 

Based 

Criteria 

for 

Consumers

Meet 

Exposure 

Based 

Criteria 

for 

Release

12 22527-63-5

Propanoic acid, 2-methyl-, 3-

(benzoyloxy)-2,2,4-

trimethylpentyl ester

> 1 - 10 > 1 - 10

C16-Rubber 

and plastic 

products; 

Code(s) 

claimed CBI Yes

Yes Yes

13 24615-84-7

2-Propenoic acid, 2-

carboxyethyl ester > 1 - 10 < 1 C20-Other Yes Yes

14 25321-41-9 Benzenesulfonic acid, dimethyl- > 1 - 10 < 1 2,843 Yes

15 25646-71-3

Methanesulfonamide, N-[2-[(4-

amino-3-

methylphenyl)ethylamino]ethyl]-

, sulfate (2:3)

> 1 - 10 < 1 Yes

C14-

Photographic 

supplies

Yes Yes

16 52556-42-0

1-Propanesulfonic acid, 2-

hydroxy-3-(2-propen-1-yloxy)-, 

sodium salt (1:1)

> 1 - 10 > 1 - 10 Yes C20-Other Yes Yes

17 61788-76-9 Alkanes, chloro > 10 - 50 > 1 - 10 176,314

C01-

Adhesives 

and sealants; 

C20-Other

Yes Yes

18 65996-79-4 Solvent naphtha (coal) > 10 - 50 > 10 - 50 C20-Other Yes Yes

19 65996-82-9 Tar oils, coal

> 100 

million - 1 

billion

> 100 million 

- 1 billion

C16-Rubber 

and plastic 

products; 

C19-Wood 

and wood 

furniture; 

C20-Other

Yes Yes

20 65996-89-6 Tar, coal, high-temp. > 1 billion 

lbs

> 1 billion 

lbs Yes 761

C12-Paints 

and coatings; 

C20-Other

Yes Yes Yes Yes Yes

21 65996-92-1 Distillates (coal tar)

> 100 

million - 1 

billion

> 100 million 

- 1 billion

C16-Rubber 

and plastic 

products; 

C19-Wood 

and wood 

furniture; 

C20-Other

Yes Yes

22 68082-78-0 Lard, oil, Me esters > 1 - 10 > 1 - 10 41,153 Yes
Table 2-1 (Continued)

 

6

CAS# Chemical Name

2006 IUR 

Production 

Volume

[Million 

lbs]

PAIR 

Production 

Volume

[Million lbs]

2006 IUR 

-

Substantial 

Human 

Exposure 

(>1,000 

Workers) 

Met

PAIR -

Substantial 

Human 

Exposure 

(>1,000 

Workers) 

Met

NOES 

Number of 

Workers

NLM 

Household 

Chemicals 

Database 

Non-CBI 

2006 IUR 

Commercial/ 

Consumer 

Code 

Description

PAIR -

Substantial 

Human 

Exposure 

(Consumer 

Use 

Indicated)

PAIR -

Substantial 

Release 

Criteria 

(>1 million 

lbs) Met 

2005 

TRI 

Data(Total 

On- and 

Off-site 

Disposal or 

Other 

Releases, 

lbs)

Meet 

Exposure 

Based 

Criteria

for 

Workers

Meet 

Exposure 

Based 

Criteria 

for 

Consumers

Meet 

Exposure 

Based 

Criteria 

for 

Release

23 68187-57-5 Pitch, coal tar-petroleum

> 100 

million - 1 

billion

> 100 million 

- 1 billion

C11-Metal 

products Yes Yes

24 68442-60-4

Acetaldehyde, reaction products 

with formaldehyde, by-products 

from

> 1 - 10 > 1 - 10 Code(s) 

claimed CBI Yes

Yes Yes

25 68610-90-2

2-Butenedioic acid (2E)-, di-C8-

18-alkyl esters > 1 - 10 > 1 - 10

Yes

Yes

26 68988-22-7

1,4-Benzenedicarboxylic acid, 

1,4-dimethyl ester, manuf. of, 

by-products from

> 10 - 50 > 10 - 50 Yes Yes

27 70693-50-4

Phenol, 2,4-bis(1-methyl-1-

phenylethyl)-6-[2-(2-

nitrophenyl)diazenyl]-

> 1 - 10 > 1 - 10 Code(s) 

claimed CBI Yes Yes

28 72162-15-3 1-Decene, sulfurized > 1 - 10 < 1 64,227 Yes

29 73665-18-6

Extract residues (coal), tar oil 

alk., naphthalene distn. residues > 50 - 100 > 100 million - 1 billion

C19-Wood 

and wood 

furniture

Yes Yes
7

Table 2-2

Chemical-by-Chemical Explanation of Findings 

CAS# Chemical Name Summary of Findings

83-41-0 2-Nitrobenzene, 1,2-dimethylPAIR indicates >1 million lbs of this chemical is released to the environment. Based on this information, this 

chemical would meet the exposure based findings criteria of “significant or substantial release.” 

This chemical met exposure based findings criteria based on:

- PAIR Production Volume Range (10 million - 50 million lb)

- Substantial Release (Greater than 1 million lbs released)

96-22-0 3-Pentanone

PAIR indicates consumer use. It is possible that products containing this chemical may be used by >10,000 

consumers. Based on this information, this chemical would meet the exposure based findings criteria of "substantial 

or significant human exposure.”

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (10 million - 50 million lb)

- Consumers potentially exceeding 10,000 people

98-09-9 Benzenesulfonyl chloride

The IUR commercial/consumer product category C16-Rubber and plastic products was reported for this chemical. 

Chemicals reporting in this category are contained in such products as tires, footwear, flooring, bottles, sporting 

equipment, games, and toys. It is expected that these products will be widely used by consumers (including children) 

and hence, may likely exceed 10,000 people. Additionally, products such as tires and flooring are also used in a 

commercial setting, which may lead to exposures of >1,000 commercial workers. Based on this information, this 

chemical would meet the exposure based findings criteria of "substantial or significant human exposure.” (All stated 

IUR commercial/consumer product categories are non-CBI)

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers potentially exceeding 1,000 based on the IUR commercial/consumer product categories (C16 ) 

- Consumers potentially exceeding 10,000 people based on IUR commercial/consumer product category (C16)
Table 2-2 (Continued)

 

8

CAS# Chemical Name Summary of Findings

98-56-6 Benzene, 1-chloro-4-(trifluoromethyl)-

The number of potentially exposed consumers is estimated to be very large based on the use (home maintenance 

product) cited in the NLM Household Chemicals Database. It is expected that home maintenance products will be 

widely used by consumers and hence, may likely exceed 10,000 people. Based on this information, this chemical 

would meet the exposure based findings criteria of "substantial or significant human exposure.” 

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Consumers potentially exceeding 10,000 people based on NLM Household Chemicals Database

111-44-4 Ethane, 1,1'-oxybis[2-chloroThe IUR commercial/consumer product category C20-Other (chemicals contained in commercial and consumer 

products not elsewhere classified) was reported for this chemical. This indicates that this chemical is present in an 

unknown number of commercial and consumer products that may potentially have a high number of exposures. 

Based on this information, this chemical would meet the exposure based findings criteria of "substantial or significant 

human exposure.” (All stated IUR commercial/consumer product categories are non-CBI)

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers potentially exceeding 1,000 based on IUR commercial/consumer product category (C20) 

- Consumers potentially exceeding 10,000 people based on IUR commercial/consumer product category (C20)

127-68-4

Benzenesulfonic acid, 3-nitro-, sodium 

salt (1:1)

The number of potentially exposed total workers exceeds 1,000 based on NOES data. The production volume data 

for the 2006 IUR data collection was compared to the production volume data for the 1986 IUR data collection for 

this chemical to see if the production volume stayed the same or increased, thereby indicating that the usage of these 

chemicals is no less than when NOES data were gathered. The 1986 reported IUR production volume range was 1 

million -10 million lbs. The 2006 IUR production volume range is 1 million -10 million lbs.

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers exceeding 1,000 based NOES data (9,386 workers)

506-51-4 1-Tetracosanol

The number of potentially exposed total workers exceeds 1,000 based on NOES data. The production volume data 

for the PAIR data collection was compared to the production volume data for the 1986 IUR data collection for this 

chemical to see if the production volume stayed the same or increased, thereby indicating that the usage of these 

chemicals is no less than when NOES data were gathered. The 1986 reported IUR production volume range was 1 

million -10 million lbs. The PAIR production volume range is 1 million -10 million lbs.

This chemical met exposure based findings criteria based on:

- PAIR Production Volume Range (1 million - 10 million lb)

- Total workers exceeding 1,000 based NOES data (1,281 workers)
Table 2-2 (Continued)

 

9

CAS# Chemical Name Summary of Findings

506-52-5 1-Hexacosanol

The number of potentially exposed total workers exceeds 1,000 based on NOES data. The production volume data 

for the PAIR data collection was compared to the production volume data for the 1986 IUR data collection for this 

chemical to see if the production volume stayed the same or increased, thereby indicating that the usage of these 

chemicals is no less than when NOES data were gathered. The 1986 reported IUR production volume range was 1 

million -10 million lbs. The PAIR production volume range is 1 million -10 million lbs.

This chemical met exposure based findings criteria based on:

- PAIR Production Volume Range (1 million - 10 million lb)

- Total workers exceeding 1,000 based NOES data (1,565 workers)

515-40-2 Benzene, (2-chloro-1,1-dimethylethyl)-

The IUR commercial/consumer product category C02-Agricultural products (non-pesticidal) was reported for this 

chemical. Chemicals reporting in this category are used to increase the productivity and quality of farm crops; 

examples include fertilizers and soil conditioners. It is expected that these products will be widely used by 

commercial workers and consumers and hence, may likely exceed 1,000 commercial workers and 10,000 consumers. 

Based on this information, this chemical would meet the exposure based findings criteria of "substantial or significant 

human exposure.” (All stated IUR commercial/consumer product categories are non-CBI)

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers potentially exceeding 1,000 based on the IUR commercial/consumer product categories (C02 ) 

- Consumers potentially exceeding 10,000 people based on IUR commercial/consumer product category (C02)

2494-89-5

Ethanol, 2-[(4-aminophenyl)sulfonyl]-, 

1-(hydrogen sulfate)

The IUR commercial/consumer product category(s) was claimed CBI for this chemical. This chemical is present in 

an unknown number of commercial and consumer products that may potentially have a high number of exposures. 

Based on this information, this chemical would meet the exposure based findings criteria of "substantial or significant 

human exposure.” 

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers potentially exceeding 1,000 based on IUR commercial/consumer product category(s) claimed CBI

- Consumers potentially exceeding 10,000 people based on IUR commercial/consumer product category claimed CBI

5026-74-4

2-Oxiranemethanamine, N-[4-(2-

oxiranylmethoxy)phenyl]-N-(2-

oxiranylmethyl)-

The total number of potentially exposed workers is likely to exceed 1,000 based on reported IUR data. 

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers potentially exceeding 1,000 based on IUR data 
Table 2-2 (Continued)

 

10

CAS# Chemical Name Summary of Findings

22527-63-5

Propanoic acid, 2-methyl-, 3-

(benzoyloxy)-2,2,4-trimethylpentyl 

ester

The IUR commercial/consumer product category C16-Rubber and plastic products was reported for this chemical. 

Chemicals reporting in this category are contained in such products as tires, footwear, flooring, bottles, sporting 

equipment, games, and toys. It is expected that these products will be widely used by consumers (including children) 

and hence, may likely exceed 10,000 people. Additionally, products such as tires and flooring are also used in a 

commercial setting, which may lead to exposures of >1,000 commercial workers. Other product category(s) was 

claimed CBI. Based on this information, this chemical would meet the exposure based findings criteria of 

"substantial or significant human exposure.” (All stated IUR commercial/consumer product categories are non-CBI)

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers potentially exceeding 1,000 based on the IUR commercial/consumer product categories (C16 ) 

- Consumers potentially exceeding 10,000 people based on IUR commercial/consumer product category (C16)

24615-84-7 2-Propenoic acid, 2-carboxyethyl ester

The IUR commercial/consumer product category C20-Other (chemicals contained in commercial and consumer 

products not elsewhere classified) was reported for this chemical. This indicates that this chemical is present in an 

unknown number of commercial and consumer products that may potentially have a high number of exposures. 

Based on this information, this chemical would meet the exposure based findings criteria of "substantial or significant 

human exposure.” (All stated IUR commercial/consumer product categories are non-CBI)

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers potentially exceeding 1,000 based on IUR commercial/consumer product category (C20)

- Consumers potentially exceeding 10,000 people based on IUR commercial/consumer product category (C20)

25321-41-9 Benzenesulfonic acid, dimethylThe total number of potentially exposed workers exceeds 1,000 workers based on NOES data. The production 

volume data for the 2006 IUR data collection was compared to the production volume data for the 1986 IUR data 

collection for this chemical to see if the production volume stayed the same or increased, thereby indicating that the 

usage of these chemicals is no less than when NOES data were gathered. The 1986 reported IUR production volume 

range was 1 million -10 million lbs. The 2006 IUR production volume range is 1 million -10 million lbs. 

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers exceeding 1,000 based NOES data (2,843 workers)
Table 2-2 (Continued)

 

11

CAS# Chemical Name Summary of Findings

25646-71-3

Methanesulfonamide, N-[2-[(4-amino3-methylphenyl)ethylamino]ethyl]-, 

sulfate (2:3)

The total number of potentially exposed workers is likely to exceed 1,000 based on reported IUR data. Additionally, 

the IUR commercial/consumer product category C14-Photographic supplies was reported for this chemical. 

Chemicals reporting in this category are contained in photographic apparatus, equipment and parts; film, paper, 

plates, and prepared photographic chemicals for commercial and consumer use. It is expected that these products 

will be widely used by commercial workers and consumers and hence, may likely exceed 1,000 commercial workers 

and 10,000 consumers. Based on this information, this chemical would meet the exposure based findings criteria of 

"substantial or significant human exposure.” (All stated IUR commercial/consumer product categories are non-CBI)

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers potentially exceeding 1,000 based on IUR data and commercial/consumer product category (C14)

- Consumers potentially exceeding 10,000 people based on IUR commercial/consumer product category (C14)

52556-42-0

1-Propanesulfonic acid, 2-hydroxy-3-

(2-propen-1-yloxy)-, sodium salt (1:1)

The IUR commercial/consumer product category C20-Other (chemicals contained in commercial and consumer 

products not elsewhere classified) was reported for this chemical. This indicates that this chemical is present in an 

unknown number of commercial and consumer products that may potentially have a high number of exposures. 

Based on this information, this chemical would meet the exposure based findings criteria of "substantial or significant 

human exposure.” (All stated IUR commercial/consumer product categories are non-CBI)

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers potentially exceeding 1,000 based on IUR commercial/consumer product category (C20)

- Consumers potentially exceeding 10,000 people based on IUR commercial/consumer product category (C20)
Table 2-2 (Continued)

 

12

CAS# Chemical Name Summary of Findings

61788-76-9 Alkanes, chloro

The total number of potentially exposed workers exceeds 1,000 workers based on NOES data. Additionally, the 

number of potentially exposed consumers is estimated to be very large based on the reported IUR 

commercial/consumer product categories for this chemical: C01-Adhesives and sealants, and C20-Other (chemicals 

contained in commercial and consumer products not elsewhere classified). Chemicals reporting in these product 

categories are contained in industrial and household adhesives, glues, caulking compounds, and sealants, along with 

an unknown number of commercial and consumer products that may potentially have a high number of exposures. It 

is expected that these products will be widely used by commercial workers and consumers and hence, may likely 

exceed 1,000 commercial workers and 10,000 consumers. Based on this information, this chemical would meet the 

exposure based findings criteria of "substantial or significant human exposure.” The production volume data for the 

2006 IUR data collection was compared to the production volume data for the 1986 IUR data collection for this 

chemical to see if the production volume stayed the same or increased, thereby indicating that the usage of these 

chemicals is no less than when NOES data were gathered. The 1986 reported IUR production volume range was 1 

million -10 million lbs. The 2006 IUR production volume range is 10 million -50 million lbs. (All stated IUR 

commercial/consumer product categories are non-CBI)

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (10 million - 50 million lb)

- Total workers exceeding 1,000 based NOES data (176,314 workers)

- Total workers potentially exceeding 1,000 based on IUR commercial/consumer product categories (C01, C20)

- Consumers potentially exceeding 10,000 people based on IUR commercial/consumer product category (C01, C20)

65996-79-4 Solvent naphtha (coal)

The IUR commercial/consumer product category C20-Other (chemicals contained in commercial and consumer 

products not elsewhere classified) was reported for this chemical. This indicates that this chemical is present in an 

unknown number of commercial and consumer products that may potentially have a high number of exposures. 

Based on this information, this chemical would meet the exposure based findings criteria of "substantial or significant 

human exposure.” (All stated IUR commercial/consumer product categories are non-CBI)

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (10 million - 50 million lb)

- Total workers potentially exceeding 1,000 based on IUR commercial/consumer product category (C20)

- Consumers potentially exceeding 10,000 people based on IUR commercial/consumer product category (C20)
Table 2-2 (Continued)

 

13

CAS# Chemical Name Summary of Findings

65996-82-9 Tar oils, coal

The IUR commercial/consumer product categories C16-Rubber and plastic products, C19-Wood and wood furniture, 

and C20-Other (chemicals contained in commercial and consumer products not elsewhere classified) were reported 

for this chemical. Chemicals reporting in these product categories are contained in tires, footwear, flooring, bottles, 

sporting equipment, games, toys, wood products and wood furniture, along with an unknown number of commercial 

and consumer products that may potentially have a high number of exposures. It is expected that these products will 

be widely used by commercial workers and consumers and hence, may likely exceed 1,000 commercial workers and 

10,000 consumers. Based on this information, this chemical would meet the exposure based findings criteria of 

"substantial or significant human exposure.” (All stated IUR commercial/consumer product categories are non-CBI)

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (100 million - 1 billion lb)

- Total workers potentially exceeding 1,000 based on IUR commercial/consumer product categories (C16, C19, C20)

- Consumers potentially exceeding 10,000 people based on IUR commercial/consumer product category 

(C16,C19,C20)

65996-89-6 Tar, coal, high-temp.

The total number of potentially exposed workers is likely to exceed 1,000 based on reported PAIR data. 

Additionally, the number of potentially exposed consumers is estimated to be very large based on the reported IUR 

commercial/consumer product categories for this chemical: C12-Paints and coatings, and C20-Other (chemicals 

contained in commercial and consumer products not elsewhere classified). Chemicals reporting in these product 

categories are commercial and consumer paints (paste or ready-mix) including artists’ paints, varnishes, lacquers, 

enamels and shellac, paint and varnish removers and cleaners, along with an unknown number of commercial and 

consumer products that may potentially have a high number of exposures. It is expected that these products will be 

widely used by commercial workers and consumers and hence, may likely exceed 1,000 commercial workers and 

10,000 consumers. PAIR indicates >1 million lbs of this chemical is released to the environment. Based on this 

information, this chemical would meet the exposure based findings criteria of "substantial or significant human 

exposure" and “significant or substantial release.” (All stated IUR commercial/consumer product categories are 

non-CBI)

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (> 1 billion lb)

- Total workers potentially exceeding 1,000 based on PAIR data

- Total workers potentially exceeding 1,000 based on the IUR commercial/consumer product categories (C12, C20 )

- Consumers potentially exceeding 10,000 people based on IUR commercial/consumer product category (C12,C20)

- Substantial Release (Greater than 1 million lbs released)
Table 2-2 (Continued)

 

14

CAS# Chemical Name Summary of Findings

65996-92-1 Distillates (coal tar)

The IUR commercial/consumer product categories C16-Rubber and plastic products, C19-Wood and wood furniture, 

and C20-Other (chemicals contained in commercial and consumer products not elsewhere classified) were reported 

for this chemical. Chemicals reporting in these product categories are contained in tires, footwear, flooring, bottles, 

sporting equipment, games, toys, wood products and wood furniture, along with an unknown number of commercial 

and consumer products that may potentially have a high number of exposures. It is expected that these products will 

be widely used by commercial workers and consumers and hence, may likely exceed 1,000 commercial workers and 

10,000 consumers. Based on this information, this chemical would meet the exposure based findings criteria of 

"substantial or significant human exposure.” (All stated IUR commercial/consumer product categories are non-CBI)

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (100 million - 1 billion lb)

- Total workers potentially exceeding 1,000 based on IUR commercial/consumer product categories (C16, C19, C20)

- Consumers potentially exceeding 10,000 people based on IUR commercial/consumer product category (C16,C19, 

C20)

68082-78-0 Lard, oil, Me esters

The total number of potentially exposed workers exceeds 1,000 workers based on NOES data. The production 

volume data for the 2006 IUR data collection was compared to the production volume data for the 1986 IUR data 

collection for this chemical to see if the production volume stayed the same or increased, thereby indicating that the 

usage of these chemicals is no less than when NOES data were gathered. The 1986 reported IUR production volume 

range was 500 thousand - 1 million lbs. The 2006 IUR production volume range is 1 million -10 million lbs. 

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers exceeding 1,000 based NOES data 

 (41,153 workers)

68187-57-5 Pitch, coal tar-petroleum

The IUR commercial/consumer product category C11-Metal products was reported for this chemical. Chemicals 

reporting in this category are contained in metal products for commercial and consumer use; metal furniture and 

furnishings are included in this category. It is expected that these products will be widely used by commercial 

workers and consumers (including children) and hence, may likely exceed 1,000 commercial workers and 10,000 

consumers. Based on this information, this chemical would meet the exposure based findings criteria of "substantial 

or significant human exposure.” (All stated IUR commercial/consumer product categories are non-CBI)

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (100 million - 1 billion lb)

- Total workers potentially exceeding 1,000 based on IUR commercial/consumer product category (C11)

- Consumers potentially exceeding 10,000 people based on IUR commercial/consumer product category (C11)
Table 2-2 (Continued)

 

15

CAS# Chemical Name Summary of Findings

68442-60-4

Acetaldehyde, reaction products with 

formaldehyde, by-products from

The IUR commercial/consumer product category(s) was claimed CBI for this chemical. This chemical is present in 

an unknown number of commercial and consumer products that may potentially have a high number of exposures. 

Additionally, PAIR indicates consumer use. It is possible that products containing this chemical may be used by 

>10,000 consumers. Based on this information, this chemical would meet the exposure based findings criteria of 

"substantial or significant human exposure.” 

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers potentially exceeding 1,000 based on IUR commercial/consumer product category(s) claimed CBI

- Consumers potentially exceeding 10,000 people based on IUR commercial/consumer product category claimed CBI

68609-05-2 Cyclohexane, oxidized This chemical met one exposure based findings criterion:

- PAIR Production Volume Range (1 million -10 million lb)

68610-90-2

2-Butenedioic acid (2E)-, di-C8-18-

alkyl esters

PAIR indicates consumer use. It is possible that products containing this chemical may be used by >10,000 

consumers. Based on this information, this chemical would meet the exposure based findings criteria of "substantial 

or significant human exposure.” 

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Consumers potentially exceeding 10,000 people

68988-22-7

1,4-Benzenedicarboxylic acid, 1,4-

dimethyl ester, manuf. of, by-products 

from

PAIR indicates >1 million lbs of this chemical is released to the environment. Based on this information, this 

chemical would meet the exposure based findings criteria of “significant or substantial release.” 

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (10 million - 50 million lb)

- Substantial Release (Greater than 1 million lbs released)

70693-50-4

Phenol, 2,4-bis(1-methyl-1-

phenylethyl)-6-[2-(2-

nitrophenyl)diazenyl]-

The IUR commercial/consumer product category(s) was claimed CBI for this chemical. This chemical is present in 

an unknown number of commercial and consumer products that may potentially have a high number of exposures. 

Based on this information, this chemical would meet the exposure based findings criteria of "substantial or significant 

human exposure.” 

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers potentially exceeding 1,000 based on IUR commercial/consumer product category(s) claimed CBI

- Consumers potentially exceeding 10,000 people based on IUR commercial/consumer product category claimed CBI
Table 2-2 (Continued)

 

16

CAS# Chemical Name Summary of Findings

72162-15-3 1-Decene, sulfurized

The total number of potentially exposed workers exceeds 1,000 workers based on NOES data. The production 

volume data for the 2006 IUR data collection was compared to the production volume data for the 1986 IUR data 

collection for this chemical to see if the production volume stayed the same or increased, thereby indicating that the 

usage of these chemicals is no less than when NOES data were gathered. The 1986 reported IUR production volume 

range was 1 million - 10 million lbs. The 2006 IUR production volume range is 1 million -10 million lbs. 

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers exceeding 1,000 based NOES data (64,227 workers)

73665-18-6

Extract residues (coal), tar oil alk., 

naphthalene distn. residues

The IUR commercial/consumer product category C19-Wood and wood furniture was reported for this chemical. 

Chemicals reporting in this category are contained in wood products and wood furniture for commercial and 

consumer use. It is expected that these products will be widely used by commercial workers and consumers 

(including children) and hence, may likely exceed 1,000 commercial workers and 10,000 consumers. Based on this 

information, this chemical would meet the exposure based findings criteria of "substantial or significant human 

exposure.” (All stated IUR commercial/consumer product categories are non-CBI)

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (50 million - 100 million lb)

- Total workers potentially exceeding 1,000 based on the IUR commercial/consumer product categories (C19 ) 

- Consumers potentially exceeding 10,000 people based on IUR commercial/consumer product category (C19)
Table 2-3

HPV Orphan Chemicals Not Included in Third Group of Chemicals

CAS# Chemical Name

1 98-16-8 Benzenamine, 3-(trifluoromethyl)-

2 124-63-0 Methanesulfonyl chloride

3 460-00-4 Benzene, 1-bromo-4-fluoro4 542-92-7 1,3-Cyclopentadiene

5 928-72-3 Glycine, N-(carboxymethyl)-, sodium salt (1:2)

6 1738-25-6 Propanenitrile, 3-(dimethylamino)-

7 28106-30-1 Benzene, ethenylethyl8 35203-06-6 Benzenamine, 2-ethyl-6-methyl-N-methylene9 35203-08-8 Benzenamine, 2,6-diethyl-N-methylene10 37734-45-5 Carbonochloridothioic acid, S-(phenylmethyl) ester

11 37764-25-3 Acetamide, 2,2-dichloro-N,N-di-2-propen-1-yl12 68609-05-2 Cyclohexane, oxidized

13 65996-91-0 Distillates (coal tar), upper

14 68153-60-6 Fatty acids, tall-oil, reaction products with diethylenetriamine, acetates

15 68442-77-3 2-Butenediamide, (2E)-, N1,N4-bis[2-(4,5-dihydro-2-nortall-oil alkyl-1H-imidazol-1-yl)ethyl] derivs.

16 68909-77-3 Ethanol, 2,2'-oxybis-, reaction products with ammonia, morpholine derivs. residues