Form of Incentive Stock Option Agreement



 Exhibit 10.16 
 HYPERION THERAPEUTICS, INC. 
 2012 OMNIBUS INCENTIVE PLAN 

INCENTIVE STOCK OPTION AGREEMENT 
 Hyperion Therapeutics, Inc., a Delaware corporation (the “Company”), hereby grants an option to purchase shares of its common stock, par value
$            per share (the “Option”), to the optionee named below, subject to the vesting and other conditions set forth below. Additional terms and conditions of the
grant are set forth in this cover sheet and in the attachment (collectively, the “Agreement”), and in the Company’s 2012 Omnibus Incentive Plan (as amended from time to time, the “Plan”). 

Grant Date:
                                         
   , 20__ 
 Name of Optionee:
                                         
                                         
           
 Optionee’s Social Security Number:
            -            -            

 Number of Shares of Stock Covered by Option:
                                 

Option Price per Share of Stock:
$            .        (At least 100% of Fair Market Value) 
 Vesting Schedule
[                                        ]

 By your signature below, you agree to all of the terms and conditions described herein, in the attached Agreement
and in the Plan, a copy of which is also attached. You acknowledge that you have carefully reviewed the Plan, and agree that the Plan will control in the event any provision of this cover sheet or Agreement should appear to be inconsistent.

  

							
	Optionee:	  	 	  	Date:	  	 
		  	(Signature)	  		  	
				
	Company:	  	 	  	Date:	  	 
		  	(Signature)	  		  	
	Title:	  		  		  	

 Attachment 
 This is not a share certificate or a negotiable instrument. 
  







 HYPERION THERAPEUTICS, INC. 

2012 OMNIBUS INCENTIVE PLAN 
 INCENTIVE STOCK OPTION AGREEMENT 
  

			
		
	Incentive Stock Option	  	This Agreement evidences an award of an Option exercisable for that number of shares of Stock set forth on the cover sheet and subject to the vesting and other conditions set
forth herein, in the Plan and on the cover sheet. This option is intended to be an incentive stock option under Section 422 of the Internal Revenue Code and will be interpreted accordingly. If you cease to be an employee of the Company, its parent
or a subsidiary (“Employee”) but continue to provide Service, this option will be deemed a nonstatutory stock option three months after you cease to be an Employee. In addition, to the extent that all or part of this option exceeds the
$100,000 rule of section 422(d) of the Internal Revenue Code, this option or the lesser excess part will be deemed to be a nonstatutory stock option.
		
	 Transfer of Option
	  	 During your lifetime, only you (or, in the event of your legal incapacity or incompetency, your guardian or legal representative) may
exercise the Option. The Option may not be sold, assigned, transferred, pledged, hypothecated or otherwise encumbered, whether by operation of law or otherwise, nor may the Option be made subject to execution, attachment or similar
process.
  
 If you attempt to do any of these things, this Option will
immediately become forfeited.

		
	 Vesting
	  	Your Option shall vest in accordance with the vesting schedule shown on the cover sheet so long as you continue in Service on the vesting dates set forth on the cover sheet and
is exercisable only as to its vested portion.
		
		  	No additional shares of Stock will vest after your Service has terminated for any reason.
		
	 Change in Control
	  	Notwithstanding the vesting schedule set forth above, upon the consummation of a Change in Control, this option will become 100% vested (i) if it is not assumed, or equivalent
options are not substituted for the options, by the Company or its successor, or (ii) if assumed or substituted for, upon your Involuntary Termination within the 12-month period following the consummation of the Change in Control. Notwithstanding
any other provision in this Agreement, if assumed or substituted for, the option will expire one year after the date of your termination of Service, for any reason, within such 12-month period.


  
 2 









			
		  	“Involuntary Termination” means termination of your Service by reason of (i) your involuntary dismissal by the Company or its successor for reasons other than
Cause; or (ii) your voluntary resignation for Good Reason as defined in any applicable employment or severance agreement, plan, or arrangement between you and the Company, or if none, then following (x) a substantial adverse alteration in your title
or responsibilities from those in effect immediately prior to the Change in Control; (y) a reduction in your annual base salary as of immediately prior to the Change in Control (or as the same may be increased from time to time) or a material
reduction in your annual target bonus opportunity as of immediately prior to the Change in Control; or (z) the relocation of your principal place of employment to a location more than 35 miles from your principal place of employment as of the Change
in Control or the Company’s requiring you to be based anywhere other than such principal place of employment (or permitted relocation thereof) except for required travel on the Company’s business to an extent substantially consistent with
your business travel obligations as of immediately prior to the Change in Control. To qualify as an “Involuntary Termination” you must provide notice to the Company of any of the foregoing occurrences within 90 days of the initial
occurrence and the Company shall have 30 days to remedy such occurrence.
		
	Forfeiture of Unvested Options / Term	  	 Unless the termination of your Service triggers accelerated vesting or other treatment of your Option pursuant to the terms of this
Agreement, the Plan, or any other written agreement between the Company or Affiliate and you, you will automatically forfeit to the Company those portions of the Option that have not yet vested in the event your Service terminates for any
reason.
  
 Your option will expire in any event at the close of business at
Company headquarters on the day before the 10th anniversary of the Grant Date, as shown on the cover sheet. Your option will expire earlier if your Service terminates, as described below.

		
	Expiration of Vested Options After Service Terminates	  	 If your Service terminates for any reason, other than death, Disability or Cause, then the vested portion of your Option will expire
at the close of business at Company headquarters on the 90th day after your termination date.
  
 If your Service terminates because of your death or Disability, or if you die during the 90-day period after your termination for any reason (other than Cause), then the vested portion of your Option will
expire at the close of business at Company headquarters on the date twelve (12) months after the date of your death or termination for Disability.



  
 3 









			
		  	 During that twelve (12) month period, your estate or heirs may exercise the vested portion of your Option.

 
 If your Service is terminated for Cause, then you shall immediately forfeit all
rights to your entire Option and the Option shall immediately expire.

		
	 Forfeiture of Rights
	  	 If you should take actions in violation or breach of or in conflict with any non-competition agreement, any agreement prohibiting
solicitation of employees or clients of the Company or any Affiliate or any confidentiality obligation with respect to the Company or any Affiliate or otherwise in competition with the Company or any Affiliate, the Company has the right to cause an
immediate forfeiture of your rights to this Option and the Option shall immediately expire.
  
 In addition, if you have exercised any options during the two year period prior to your actions, you will owe the Company a cash payment (or forfeiture of shares of Stock) in an amount determined as
follows: (1) for any shares of Stock that you have sold prior to receiving notice from the Company, the amount will be the proceeds received from the sale(s), less the option exercise price, and (2) for any shares of Stock that you still own, the
amount will be the number of shares of Stock owned times the Fair Market Value of the shares of Stock on the date you receive notice from the Company, less the option exercise price (provided, that the Company may require you to satisfy your payment
obligations hereunder either by forfeiting and returning to the Company the shares of Stock or any other shares or making a cash payment or a combination of these methods as determined by the Company in its sole discretion).

		
	 Leaves of Absence
	  	 For purposes of this Agreement, your Service does not terminate when you go on a bona fide leave of absence that was approved
by your employer in writing if the terms of the leave provide for continued Service crediting, or when continued Service crediting is required by applicable law. Your Service terminates in any event when the approved leave ends unless you
immediately return to active employee work.
  
 Your employer may determine,
in its discretion, which leaves count for this purpose, and when your Service terminates for all purposes under the Plan in accordance with the provisions of the Plan. Notwithstanding the foregoing, the Company may determine, in its discretion, that
a leave counts for this purpose even if your employer does not agree.

		
	 Notice of Exercise
	  	The Option may be exercised, in whole or in part, to purchase a whole number of vested shares of Stock of not less than 100 shares, unless


  
 4 









			
		  	 the number of vested shares of Stock purchased is the total number available for purchase under the option, by following the
procedures set forth in the Plan and in this Agreement.
  
 When you wish to
exercise this Option, you must exercise in a manner required or permitted by the Company.
  
 If someone else wants to exercise this Option after your death, that person must prove to the Company’s satisfaction that he or she is entitled to do so.

		
	 Form of Payment
	  	 When you exercise your Option, you must include payment of the option price indicated on the cover sheet for the shares of Stock you
are purchasing. Payment may be made in one (or a combination) of the following forms:
  
 •    Cash, your personal check, a cashier’s check, a money order or another cash equivalent acceptable to the Company.

 
 •    Shares of Stock which are owned by
you and which are surrendered to the Company. The Fair Market Value of the shares of Stock as of the effective date of the option exercise will be applied to the option price.

 
 •    By delivery (on a form prescribed
by the Company) of an irrevocable direction to a licensed securities broker acceptable to the Company to sell shares of Stock and to deliver all or part of the sale proceeds to the Company in payment of the aggregate option price and any withholding
taxes (if approved in advance by the Committee of the Board if you are either an executive officer or a director of the Company).

		
	 Evidence of Issuance
	  	The issuance of the shares of Stock upon exercise of this Option shall be evidenced in such a manner as the Company, in its discretion, will deem appropriate, including, without
limitation, book-entry, direct registration or issuance of one or more Stock certificates.
		
	 Withholding Taxes
	  	You agree as a condition of this grant that you will make acceptable arrangements to pay any withholding or other taxes that may be due as a result of the Option exercise or sale
of shares of Stock acquired under this Option. In the event that the Company or any Affiliate determines that any federal, state, local or foreign tax or withholding payment is required relating to the exercise of this Option or sale of shares of
Stock arising from this Option, the Company or any Affiliate shall have the right to require such payments from you, or withhold such amounts from other payments due to you from the Company or any Affiliate (including withholding the delivery
of


  
 5 









			
		  	vested shares of Stock otherwise deliverable under this Agreement).
		
	 Retention Rights
	  	This Agreement and the grant evidenced hereby do not give you the right to be retained by the Company or any Affiliate in any capacity. Unless otherwise specified in an
employment or other written agreement between the Company or any Affiliate and you, the Company or any Affiliate reserves the right to terminate your Service at any time and for any reason.
		
	 Shareholder Rights
	  	 You, or your estate or heirs, have no rights as a shareholder of the Company until the shares of Stock has been issued upon exercise
of your Option and either a certificate evidencing your shares of Stock has been issued or an appropriate entry has been made on the Company’s books. No adjustments are made for dividends, distributions or other rights if the applicable record
date occurs before your certificate is issued (or an appropriate book entry is made), except as described in the Plan.
  
 Your Option shall be subject to the terms of any applicable agreement of merger, liquidation or reorganization in the event the Company is subject to such corporate activity.

		
	 Clawback
	  	 This Award is subject to mandatory repayment by you to the Company to the extent you are or in the future become subject to any
Company “clawback” or recoupment policy that requires the repayment by you to the Company of compensation paid by the Company to you in the event that you fail to comply with, or violate, the terms or requirements of such
policy.
  
 If the Company is required to prepare an accounting restatement
due to the material noncompliance of the Company, as a result of misconduct, with any financial reporting requirement under the securities laws and you knowingly engaged in the misconduct, were grossly negligent in engaging in the misconduct,
knowingly failed to prevent the misconduct or were grossly negligent in failing to prevent the misconduct, you shall reimburse the Company the amount of any payment in settlement of this Award earned or accrued during the 12-month period following
the first public issuance or filing with the United States Securities and Exchange Commission (whichever first occurred) of the financial document that contained such material noncompliance.

		
	 Applicable Law
	  	This Agreement will be interpreted and enforced under the laws of the State of Delaware, other than any conflicts or choice of law rule or principle that might otherwise refer
construction or interpretation of this Agreement to the substantive law of another jurisdiction.


  
 6 









			
	 The Plan
	  	 The text of the Plan is incorporated in this Agreement by reference.

 
 Certain capitalized terms used in this Agreement are defined in the Plan, and
have the meaning set forth in the Plan.
  
 This Agreement and the
Plan constitute the entire understanding between you and the Company regarding this Option. Any prior agreements, commitments or negotiations concerning this grant are superseded; except that any written employment, consulting, confidentiality,
non-competition, non-solicitation and/or severance agreement between you and the Company or any Affiliate shall supersede this Agreement with respect to its subject matter.

		
	 Data Privacy
	  	 In order to administer the Plan, the Company may process personal data about you. Such data includes, but is not limited to,
information provided in this Agreement and any changes thereto, other appropriate personal and financial data about you such as your contact information, payroll information and any other information that might be deemed appropriate by the Company
to facilitate the administration of the Plan.
  
 By accepting this grant,
you give explicit consent to the Company to process any such personal data.

		
	 Code Section 409A
	  	It is intended that this Award comply with Code Section 409A or an exemption to Code Section 409A. To the extent that the Company determines that you would be subject to the
additional 20% tax imposed on certain non-qualified deferred compensation plans pursuant to Code Section 409A as a result of any provision of this Agreement, such provision shall be deemed amended to the minimum extent necessary to avoid application
of such additional tax. The nature of any such amendment shall be determined by the Company. For purposes of this Award, a termination of Service only occurs upon an event that would be a Separation from Service within the meaning of Code Section
409A.

 By signing this Agreement, you agree to all of the terms and conditions described above and in the
Plan. 

  
 7