### 2



The maximum proposed appl ication rate for the proposed foliar use s is for dry shelled beans (except soybeans), at 0.18 lbs ai/acre/application, applied 2 time s per year with a 7
- day reapplication interval for a maximum total annual application rate of 0.36 lb ai/A/yr
. The maximum proposed application rate for the proposed new seed uses is for wheat and triticale seed, at 0.068 lbs ai/acre/application, applied one time per year for a maximum total annual application rate of 0.068 lb ai/A/yr. This application rate is based on an application rate of 0.05 lbs ai per 100 lbs of seed and an assumed planting rate of 135 lbs of seed planted per acre (USEPA model TREX Version 1.4.1 [http://www.epa.gov/oppefed1/mo dels/terrestrial/index.htm#trex]) and a planting depth of 2 inches
. The computer models FIRST (surface water) and SCI GROW (groundwater) were used to predict the EDWCs for use in the human health dietary risk assessment. Fluxapyroxad is the only resi d ue of concern in drinking water. For aerial applications to dry shelled beans (except soybeans) , the estimated acute concentration of fluxapyroxad in surface water sources of drinking water is **14.1 μg/L** 
. The estimated chronic concentration is **6.7 μg/L** 
. The acute and chronic values for wheat and triticale seed applications were 1.22 and 0.55 ppb , respectively
. The FIRST output file is provided in **Appendix B**
. For groundwater sources of drinking water, the estimated concentration of fluxapyroxad in shallow groundwater for applications to dry shelled beans (except soybeans) is **0.087 μg/L.**  The reported value for wheat and triticale seed applications is 0.017 ppb. The SCIGROW output file is provided in **Appendix B**
. Maximum EDWCs for fluxapyroxad in surface water and groundwater are presented below in **Table 1**  ; complete modeling results are presented in **Table 6** 
. **Table 1**  **. Maximum T**  **ier I estimated drinking water concentrations for fluxapyroxad use. DRINKING**  **WATER SOURCE (M**  **ODEL USED) USE (rate m** **odeled) MAXIMUM ESTIMATED**  **DRINKING WATER CONCENTRATION (EDWC) ( ppb)**  **1 -** **in -**  **10 year acute (**  **μg/L )**  **1 -** **in -**  **10 year**

**chronic ( μg/L** **)** Surface Water (FIRST) Aerial Foliar

(dry shelled beans at 0.18 lbs ai/A x 2) **14.1 6.70**  Groundwater (SCIGROW) Aerial Foliar

(dry shelled beans at 0.18 lbs ai/A x 2) 0.087 0.087 This assessment is based on available environmental fate data. There are no significant data gaps in the environmental fate databas e submitted by the registrant. Since this is a new chemical there is no existing monitoring data for fluxapyroxad. **PROBLEM FORMULATION** This is a Tier I drinking water assessment (DWA) that uses modeling to estimate the groundwater and surface water concentrations of pesticides in drinking water source water (pre

-treatment) resulting from pesticide use on sites that are vulnerable. T ier I DWAs are designed to screen out chemicals with low potential risk for posing a drinking water concern
.

###  3



**ANALYSIS Use Characterization**  Fluxapyroxad (BAS 700 F) is a second generation carboxamide fungicide, designed to inhibit the mitochondrial respiratory chain (Complex II Succinate Dehydrogenase, SDH). Iti s being proposed for a number of crops including wheat, barley, corn, bean and pea legumes, peanuts, pome and stone fruits, fruiting vegetables, oil seed, root and tuberous vegetable crops. Iti s also being proposed as a seed treatment for use on b arley, corn, cotton, dried shelled peas and beans, edible podded legume vegetables, oat, peanut, rye, sorghum, soybean, sunflower, wheat and triticale seed
. Two of the proposed products (BAS 703 01 F and BAS 703 02 F ) also contain the active ingredient pyraclostrobin, which is being proposed at application rates equivalent to or higher than f luxapyroxad. This evaluation is limited to the exposure associated with fluxapyroxad alone and does not include exposure associated with pyraclostrobin. Application information for the prop o sed new use on dry shelled beans (except soybeans) and wheat and triticale seed applications is presented in 

### Table **2**

. A complete listing of the proposed new uses for fluxapryoxad products is provided in **Appendix A** 
. **Table 2**  **. Summary use information for fluxapyroxad proposed new use on dry shelled beans (except soybeans) and wheat and triticale seed applications.** 

**Use Max.**  **Single**

**Applic ation**  **Rate (lbs. a.i./A)**  **No. of** 

**Applic ations**  **Annual**

**Applic ation**  **Rate (lbs. a.i./A** **/yr )**  **Interval**

**Between Applic**  **ations (days)**  **Applic ation** 

**Me thod**  Dry shelled beans (except soybeans) 0.18 2 0.36 7 Aerial Wheat and triticale seed applications 0.068 1 0.068 NA Incorporated **Environmental Fate and Transport Characterization**  Fluxapyroxad is stable to hydrolysis at pH of 5, 7 and 9; and to both soil and aqueous photolysis. Fluxapyroxad is not expected to volatilize (vapor pressure greater than 6.1 x 10 - 11 Torr at 25  ̊ C). Fluxapyroxad does not readily undergo aerobic or anaerobic degradation in soil, with single first

- order half

- lives ranging from 213 to 1,827 days. There did not appear to be any relationship between soil metabolism half

- lives and pH, organic carbon , or cation exchange capacity. Itshould be noted, though, that low CO 2 levels were observed in the aerobic soil metabolism studies , as well as a lack of transformation product formation, an increase in unextracted residue formation with an increase in temperature without an effect on CO 2 and transformation product formation, and the detection of parent in unextracted residue (MRID 47923684). C oupled with the fact that fluxapyroxad is moderately to slightly mobile (see mobility discussion below) , there is the potential that the half

- life values determined in these studies are more representative of adsorption than of biotransformation. Fluxapyroxad does not readily undergo aerobic or anaerobic degradation in aquatic systems , with single first

- order half

- lives ranging from 420 to 731 days. In aerobic aquatic studies, fluxapyroxad

### 4



partitioned to sediment, reaching levels in sediment above 50% of the applied between 3 and 7 days after treatment. In the terrestrial field dis sipation studies conducted on bare soil at six locations throughout North America, fluxapyroxad was detected infrequently below the top 6 inches of the soil, dissipating with half

lives ranging from 17 to 436 days. Fluxapyroxad is classified as moderate ly to slightly mobile (FAO soil mobility classification) based on adsorption KOC values in two U.S. soils ranging from 725 to 1,200 mL/goc . Adsorption KOC values for six foreign soils were similar, ranging from 496 to 1,424 mL/goc . Freundlich soil partitioning coefficients (KF) for adsorption for the two U.S. soils ranged from 2.5 to 8.6 ml/g (4.3 to 17.9 ml/g for foreign soils). F luxapyroxad has the potential to leach to ground water, particularly where high water tables are present, high rainfall/irrigation occurs , and where s andy soils with low organic matter exist
. As mentioned above, in the maj ority of terrestrial field dissipation studies, fluxapyroxad was detected infrequently at depths greater than 6 inches. However, given fluxapyroxad’s persistence and mobility, the terrestrial field dissipation studies, which only lasted a maximum of 472 days, may not have been long enough to capture leaching over time. A bioconcentration in fish (BCF ) laboratory study involving bluegill sunfish (MRID 47923730) indicated that after 28 days of exposure to fluxapyroxad (1.0 and 10.0 μg a.i./L), whole fish BCF values (based on total radioactivity) were 86 and 93 (μg/kg

-ww per μg/L), respectively. Time to reach 90% depuration was 2.5 and 2.4 days, respectively. Therefore, fluxapyroxad will not likely bioaccumulate. A summary of the maximum amount of degradation products in the studies discussed above is provided in **Appendix C** 
. B ased on discussions with the Residues of Concern Knowledgebase Subcommittee (ROCKS), only the parent compound is of concern for drinking water purposes (D390225, 7/14/2011). **Table 3**  summarizes the physicochemical properties of fluxapyroxad. **Table 3**  **. Physical and**  **chemical properties for fluxapyroxad. Chemical Fate/Param** **eter Value**  **Source (M**  **RID) Comments**  IUPAC Name 3
- (difluoromethyl)

- 1
- methyl

-N
- (3',4',5'

-trifluoro[1,1'

-biphenyl]

- 2
- yl)

- 1 H
-py

razole

-4
- carboxamide Chemical Formula C 18 H 12F 5N 3 O Chemical Structure

Molecular Mass (g/mol) 381.31 Vapor Pressure (25°C) ( Torr) 6.1 x 10 - 11 47923505 Not expected to volatilize Solubility (20°C) (ppm) 3.44 (pH 7) 47923509 Octanol

-water partition coefficient (Kow) 1 , 288 (log Kow = 3.11) 47923511 Dissociation constant (pKa) 12.58 47923514

###  5



**Chemical Fate/Param eter**  **Value Source**  **(M RID)**  **Comments** Hydrolysis half

- life (pHs 5,7,9 ; 25 °C) No evidence of degradation at all three pH s 4 8409101 Aqueous photolysis half

- life No evidence of degradation 47923513 Soil photolysis half

- life No evidence of degradation 47923690 Aerobic soil metabolism half

life; soil texture 213 days (NJ, loam) 1 1,82 7 days (ID, sandy loam) 2 676 days (IL, loam) 2 387 days (WI, loamy sand) 2 47923684 No observed correlation between half

- lives and individual soil properties. 72 9 days (CA, sandy loam) 2 295 days (GA, sandy loam) 2 ,3 345 days (IN, loam) 2 ,3 238 days (NC, sandy loam) 2 ,3 47923691

Anaerobic soil metabolism half

- life; soil texture 591 days (NJ, loam) 2 47923688 Aerobic aquatic metabolism half

- life 420 days (silt loam) 2 701 days (sand) 2 47923713 P artitioned mainly to sediments Anaerobic aquatic metabolism half

- life 731 days 4792371 4 Supplemental Range of Freundlich soil partition coefficients (KF , mL/g) for adsorption; 8.6 (NJ, silt loam) 2.5 (CA, sandy loam) 6.8 (Germany, loamy sand) 4.2 (Germany, sand) 5.7 (Germany, loamy sand) 12.3 (Spain, silty clay) 18.3 (Germany, clay silt) 14.0 (Japan, sandy silt) 47923707 S ix foreign soils found to be representative of agricultural areas where the pesticide will be used
. Range of organic carbon partition coefficient s (K oc , mL/g oc) 1,195 (NJ, silt loam) 725 (CA, sandy loam) 981 (Germany, loamy sand) 978 (Germany, sand) 827 (Germany, loamy sand) 496 (Spain, silty clay) 1,424 (Germany, clay silt) 819 (Japan, sandy silt) 47923707 S ix foreign soils found to be representative of agricultural areas where the pesticide will be used
. Terrestrial field dissipation half

- life 76 days (MB 4 , clay loam) 16.7 days (TX, clay loam) 120 days (IL, silt loam) 332 days (NY, sandy loam) 314 days (CA , sandy loam) 436 days (WI , sand) 47923695 47923696
47923697 All applications

were to bareground.

Bioconcentration factor 86
- 93(whole fish) 47923730 1 Estimates using the first

- order, multiple

- com partment (FOMC) provided a better fit to the data, but, as single first

order (SFO) estimates are used in modeling, the half

- life presented is from a SFO fit of the data. 2 Half

- lives extrapolated beyond length of studies (368 days for MRID 47923684, 120 days for MRID 47923691, 123 days for MRID 47923688, 100 days for MRID 47923713, and 365 days for MRID 47923714). 3 These estimates are based on SFO. Based on the interim EFED kinetics modeling guidance, SFO is not applicable and these values can be as high as 613 (GA), 2,580 (IN), and 1,561 (NC) days. 4 MB

– Manitoba, Canada

###  6



**Drinking Water Exposure Modeling**  **Models** Estimated Drinking Water Concentrations (EDWC s ) in surface water was estimated using EFED’s Tier I aquatic model FIRST (v1.1. 1 ; 3/25/08 ) . FIRST (FQPA Index Reservoir Screening Tool) is a metamodel of PRZM and EXAMS used as a screening tool to estimate pesticide concentrations found in surface water used as drinking water. F IRST was developed by making multiple runs of PRZM using varying sorption coefficients and determining the concentration in the EXAMS index reservoir scenario after a two -inch single storm event. The Index Reservoir is a standard water body used by the Office of Pesticide Programs to assess drinking water exposure (Office of Pesticide Programs, 2002). It is based on a real reservoir (albeit not currently in active use as a drinking water supply), Shipman City Lake in Il lino is, that is known to be vulnerable to pesticide contamination)
. The single runoff event moves a maximum of 8% of the applied pesticide into the reservoir. This amount can be reduced by degradation or effects of binding to soil in the field. Additionally, FIRST can account for spray drift and adj usts for the area within a watershed that is planted with the modeled crop (Percent Cropped Area). Spray drift (modeled as direct deposition of the pesticide into the reservoir) is assumed to be 16% of the appli ed active ingredient for aerial application, 6.3% for orchard air blast application, and 6.4% for other ground spray application. Despite being a single event model, FIRST can account for spray drift from multiple applications. The Percent Cropped Area (P CA) of 87% was used for the dry shelled beans (except soybeans) and wheat/triticale seed application new use s . The PRZM scenario used for FIRST development was among the most vulnerable, and thus resulting surface water concentrations represent the upper bound values on the concentrations that might be found in drinking water from the use of a pesticide. (**Ref. 2 and**  **3** ) An EDWC in groundwater was estimated using EFED’s Tier I groundwater model SCIGROW (Screening Concentration in Ground Water, version 2.3 ; 8/8/2003 ). SCIGROW is a regression model used as a screening tool to estimate pesticide concentrations found in ground water used as drinking water. S CIGROW was developed by fitting a linear model to groundwater concentrations with the Relative Index of Leaching Potential (RILP) as the independent variable. Groundwater concentrations were taken from 90

- day average high concentrations from Prospective Ground Water studies; the RILP is a function of aerobic soil metabolism and the soil

-water partition coef ficient. The output of SCIGROW represents the concentrations that might be expected in shallow unconfined aquifers under sandy soils, which is representative of the ground water most vulnerable to pesticide contamination likely to serve as a drinking water source. (**Ref. 1**  ) **Modeling Approach and Input Parameters** Tier I modeling was conducted for the EDWC s in surface water and groundwater from fluxapyroxad use on dry shelled beans (except soybeans) at 0.18 lbs ai/acre/application, applied 2 times per year with a 7

- day reapplication interval for a maximum total annual application rate of 0.36 lb ai/A/yr. Modeling was also done for wheat and triticale seed treatment application at 0.068 lbs ai/acre/application, applied one time per year for a maximum total annual application rate of 0.068 lb ai/A/yr. Physical/chemical properties and environmental fate source data (from submitted studies) were presented in **Table 3**  **.** Input values used for surface water modeling with FIRST are presented in **Table 4**  **.** Input values used for groundwater modeling with SCIGROW are presented in **Table 5** 
. In running FIRST, the mean adsorption coefficient (Koc = 931 mL/goc) was used because the Koc model is valid for this compound ( i.e. , binding was correlated with organic carbon)
. In running

###  7



SCIGROW, however, the median Koc value of 902 mL/goc (median value) was used , per guidance
. In running FIRST, an aerobic soil metabolism half

- life of 857 days was used, as it represents the 90 th percentile on the mean for 8 available half

- lives. In running SCIGROW, an aerobic soil metabolism half

life of 366 days was used, as it represents the median value for these eight half

- live s. Itshould also be noted that there was five

- fold difference in the range of the values. To simulate seed treatment application , a granular application was used in FIRST to eliminate spray drift and allow for an incorporation depth of 2 inches for the seeds. **Table 4**  **. Input values for the FIRST model for fluxapyroxad. Variable Nam** **e Data Value**  **Data Source MRID(s)**  **Comment** Application Method Aerial (dry shelled beans), granular (wheat/triticale seeds) Proposed labels Application Rate (lbs. ai/acre) 0.18 (dry shelled beans ), 0.068 (wheat/triticale seeds) Proposed labels Application Frequency 2 (dry shelled beans), 1 (wheat/triticale seeds) Proposed labels Application Interval (days) 7 (dry shelled beans), not applicable (w

heat/triticale seeds) Proposed

labels Incorporation depth (in) 0 (dry shelled beans), 2 (wheat/triticale seeds) -- No incorporation for foliar application, 2 inches assumed for seeds Solubility 3.44 ppm 47923509 Hydrolysis t 1/2 = stable 48409101 Photolysis t 1/2 = stable 47923513 Aerobic Soil Metabolism t 1/2 = 857 days 47923684, 47923691 90 th percentile on

mean ( 589 days ) of 8 values 1 Aerobic Aquatic Metabolism t 1/2 = 993 days 47923713 90 th percentile on mean (561 days) of 2 values 1 Koc 931 mL/goc 47923707 Mean of eight values 1
**1** EFED input parameter guidance is located at: http://www.epa.gov/oppefed1/models/water/input_parameter_guidance.htm **Table 5**  **. Input values for the SCI GROW model for fluxapyroxad.**  **Variable Nam e**  **Data Value Data Source**  **MRID(s) Comment**  Application Rate (lbs. ai/acre) 0.18 (dry shelled beans ), 0.068 (wheat/triticale seeds) Proposed labels Application Frequency 2 (dry shelled beans), 1 (wheat/triticale seeds) Proposed labels Aerobic Soil Metabolism t 1/2 = 366 days 47923684, 47923691 Median value of 8

values ranging from 213 to 1827 1

###  8

 **Variable Nam e**  **Data Value Data Source**  **MRID(s) Comment**  Koc 902 mL/goc 47923707 Median of eight values 1 **1** EFED input parameter guidance is located at: http://www.epa.gov/oppefed1/models/water/input_parameter_guidance.htm **Modeling Results** Tier I surface water and groundwater modeling results for fluxapyroxad for aerial application to dry shelled beans and seed applications are presented in **Table 6**  **.** These values are recommended for use in the human health risk assessment. An analysis of ground application of fluxapyroxad was also conducted, but the acute and chronic EDWCs were lower than those for aerial applications. Output values for surface water are modified using the PCA adjustment factor of 0.87
. Output values for groundwater are not adjusted for a PCA. Outputs from the model runs are provided in **Appendix B**
. **Table 6**  **. Tier I estimated drinking water concentrations based on fluxapyroxad use. DRINKING WATER**  **SOURCE (MODEL USED)**  **USE (rate modeled) MAXIMUM ESTIMATED DRINKING**  **WATER CONCENTRATION (EDWC) ( ppb) 1**  **- in** **- 10 year acute**  **( μg/L** **) 1**  **- in** **- 10 year** 

**chronic (**  **μg/L )**  Surface Water (FIRST) Aerial Foliar

(dry shelled beans at 0.18 lbs ai/A x 2) **14.1 1**  **6.70** Seed (wheat/triticale at 0.068 lbs ai/A x 1) 1.22 0.55 Groundwater (SCIGROW) Aerial Foliar

(dry shelled beans at 0.18 lbs ai/A x 2) **0.087 0.087**  Seed (wheat/triticale at 0.068 lbs ai/A x 1) 0.017 0.017 1 Bolded values are recommended for use in the human health dietary risk assessment. The SCIGROW concentration represents the groundwater concentration that might be expected in shallow unconfined aquifers under sandy soils. The output is used for both acute and chronic endpoints. FIRST concentrations (ppb) represent untreated surface water concentrations. The one -in

- 10
-year peak day concentration is used for acute endpoints and the one

-in

- 10
-year annual average concentration is used for chronic endpoints. The estimated concentrations provided in this assessment are conservative estimates of concentrations in drinking water. If dietary risks require refinement, higher tiered crop - specific and location

- specific models and modeling scenarios can be used. **Monitoring Data** As fluxapyroxad is a new active ingredient, no monitoring data are avai lable. **Drinking Water Treatment Effects** As fluxapyroxad is a new active ingredient, no specific information on the effects of drinking water treatment is available. The EDWCs in this assessment are representative of concentrations in drinking water source water (pre

-treatment) and are derived from daily instantaneous peak concentrations.

###  9



For surface water, the conceptual model assumes that a pesticide re aches surface water via spray drift or surface runoff, where it is instantaneously mixed and concentrations are observed in the water body. Fluxapyroxad is stable to hydrolysis , therefore it will not degrade during the time that elapses from drinking water intake through distribution to the first tap. Because of its Koc values, treatment methods , such as sedimentation, flocculation, and activated carbon, are expected to be marginally effective at removing fluxapyroxad
. Fluxapyroxad also does not degrade d ue to photolysis. I f ultraviolet light were used as a means of disinfection, degradation of fluxapyroxad would not be expected. **Uncertainties and Data Gaps** This assessment is based on available environmental fate data. There are no significant data gaps in the environmental fate database submitted by the registrant. The Tier I drinking water assessment i s a screening

- level assessment based on simplified models and assumptions. The modeling assessment relie s on maximum use patterns and national default PCAs to reflect potential surface and groundwater concentrations. T o the extent that actual use patterns are less than the labeled maximums and the location

- specific PCAs are less than assumed in this assessment, actual environmental exposures could be lower. As noted in the Fate section, low CO 2 levels were observed in the aerobic soil metabolism studies , as well as a lack of transformation product formation, an increase in unextracted residue formation with an increase in temperature without an effect on CO 2 and transformation product formation, and the detection of parent in unextracted residue (MRID 47923684). C oupled with the fact that fluxapyroxad is moderately to slightly mobile in soil, there is the potential that the half

- life values determined in these studies are more representative of adsorption than of biotransformation. Consequently, there is the potential for fluxapyroxad to accumulate in soils via adsorption and not degrade, such that at some point the sorption sites could become overwhelmed and fluxapyroxad could more easily be transported to surface water via runoff. While there is some uncertainty surrounding the aerobic soil half

- lives, given the low application rates for fluxapyroxad the potential to overwhelm sorption sites is considered low. **References** 1. SCIGROW: Users Manual (11/01/2001, revised 08/23/2002) 2. FIRST Users Manual ( 03/26/2008 ) 3. FIRST: A Screening Model to Estimate Pesticide Concentrations in Drinking Water ( 03/26/2008 ) 4. Guidance for Selecting Input Parameters in Modeling the Environmental Fate and Transport of Pesticides, Version 2.1 ( 10/22/200 9 ) (http://www.epa.gov/oppefed1/models/water/input_parameter_guidance.htm) 5. Development and Use of Percent Cropped Area Adjustment Factors in Drinking Water Exposure Assessments ( 9/9/2010 ) (http://www.epa.gov/oppefed1/models/water/pca_adjustment_dwa.html)
**MRIDs** MRID: 47923505 Kroehl, T. (2006) Physical Properties: Pure Active Ingredient. Project Number: 2006/1036276/OCR, 267469/1/OCR. Unpublished study prepared by BASF Aktiengesellschaft. 20 p.

###  10



MRID: 47923509 Wilfinger, W. (2008) Water Solubility of BAS 700 F at 20 Degrees Celsius. Project Number: 2007/1056999/OCR, 267487/ 1EXT/OCR, 20071489/01/PCSB. Unpublished study prepared by Eurofins

GAB GmbH. 53 p. MRID: 47923511 Wilfinger, W. (2008) Partition Coefficient of BAS 700 F (HPLC Method). Project Number: 2007/1057001/OCR, 20071489/01/PCPC/OCR, 267475/1EXT. Unpublished study prepared by Eurofins

- GAB GmbH. 42 p. MRID: 47923513 Hassink, J. (2009) Aqueous Photolysis of BAS 700 F. Project Number: 2009/1031228/OCR, 314718/OCR. Unpublished study prepared by BASF Aktiengesellschaft. 26 p. MRID: 47923514 Wilfinger, W. (2008) Dissociation Constant of BAS 700 F in Water. Project Number: 2007/1057000/OCR, 267478/1EXT/OCR, 20071489/01/PCDC. Unpublished study prepared by Eurofins

- GAB GmbH. 30 p. MRID: 47923684 Malinsky, D. (2010) Aerobic Soil Metabolism of (Carbon 14)

-BAS 700 F on US Soils: Final Report. Project Number: 2009/7003246/ocr, 002/57/01//US/319649, 2009/7003246. Unpublished study prepared by BASF Agricultural Research Center. 139 p. MRID: 47923688 Malinsky, D. (2010) Anaerobic Soil Metabolism of (Car bon 14)

-BAS 700 F on US Soil: Final Report. Project Number: 2009/7003247/ocr, //SubNo/201002/56/01, 2009/7003247. Unpublished study prepared by BASF Agricultural Research Center. 131 p. MRID: 47923690 Hassink, J. (2009) Soil Photolysis of BAS 700 F. Project Number: 2009/1013342/US/ocr, EU/314704, 2009/1013342. Unpublished study prepared by BASF SE. 42 p. MRID: 47923691 Ta, C. (2010) Rate of Degradation of BAS 700 F in Soils: Final Report. Project Number: 2009/7006123/ocr, //SubNo/201002/37/01, 20 9/7006123. Unpublished study prepared by BASF Agricultural Research Center and Agvise, Inc. 133 p. MRID: 47923695 Jordan, J.; Warren, R. (2010) Terrestrial Field Dissipation of BAS 700 F Following Applications of BAS 700 AC F in Legumes. Project Number: 2009/7006030/ocr, //SubNo/201003/03/01, 2009/7006030. Unpublished study prepared by BASF Agricultural Research Center. 293 p. MRID: 47923696 Jordan, J.; Warren, R. (2010) Terrestrial Field Dissipation of BAS 700 F Following Applications of BAS 700 AC F or BAS 700 AE F in Vegetable Use Patterns. Project Number: 2009/7006032/ocr, //SubNo/201003/02/01, 2009/7006032. Unpublished study prepared by BASF Agricultural Research Center. 756 p.

###  11



MRID: 47923697 Jordan, J. (2010) Terrestrial Field Dissipation of BAS 700 F Following Applications of BAS 700 AC F in Orchard and Vineyard Use Patterns. Project Number: 2009/7006033/ocr, //SubNo/201002/60/01, 2009/7006033. Unpublished study prepared by BASF Agricultural Research Center. 505 p. MRID: 47923707 Has sink, J.; Stephan, A. (2009) Determination of the Adsorption/Desorption Behaviour of BAS 700 F on Different Soils. Project Number: 2009/1065633/OCR, 2009/1065633, 314706. Unpublished study prepared by BASF Aktiengesellschaft. 78 p. MRID: 47923713 Ebert, D. (2009) Degradation of BAS 700 F in Water/Sediment Systems under Aerobic Conditions. Project Number: 2009/1004082/OCR, 2009/1004082, 314715. Unpublished study prepared by BASF Aktiengesellschaft. 151 p. MRID: 47923714 Ta, C. (2010) BAS 700 F: Anaerobic Aquatic Metabolism. Project Number: 2009/7006124/OCR, 2009/7006124, 319648. Unpublished study prepared by BASF Agro Research and Agvise Laboratories, Inc. 105 p. MRID: 47923730 Hafemann, C.; Kloeppner, U. (2009) Bioc oncentration and Metabolism of BAS 700 F in Bluegill Sunfish (Lepomis macrochirus). Project Number: 2009/1012801/OCR, 2009/1012801, 315780. Unpublished study prepared by BASF Aktiengesellschaft. 163 p. MRID: 48409101 Hassink, J. (2011) BAS 700 F: Aque ous Hydrolysis at Four Different pH Values (Including Amendment No. 1). Project Number: 324301, 2011/7000318. Unpublished study prepared by BASF Aktiengesellschaft. 19 p.

###  12

 **Appendix A Proposed products for registration containing fluxapyroxad**  **Proposed New End** **- Use**  **Product Nam e**  **Summary Formulation Details:** Form ulation Type lb fluxapyroxad/gal of product ( lb ai pyraclostrobin/gal of product) **Application Type Crops** 
**BAS 700 01 F Fungicide**  **Reg No. 7969 -** **XXX** Emulsifiable C oncentrate 0.52 Foliar Aerial and ground Wheat, barley, corn, bean and pea legumes,

peanuts, pome and stone fruits, fruiting vegetables, oil seed, root and tuberous vegetable crops. **BAS 700 02 F Fungicide Seed**  **Treatm ent**  **Reg No. 7969 -** **XXX** S uspension C oncentrate 0.78 Seed Treatment Barley, corn, cotton, dried shelled peas and beans, edible podded legume vegetables, oat, peanut, rye, sorghum, soy bean, sunflower, wheat and triticale seed **BAS 700 03 F Fungicide Seed**  **Treatm ent**  **Reg No. 7969 -** **XXX** S uspension C oncentrate 2.72 Seed Treatment Barley, corn, cotton, dried shelled peas and beans, edible podded legume vegetables, oat, peanut, rye, sorghum, soy bean, sunflower, wheat and triticale seed **BAS 700 04 F Fungicide**  **Reg No. 7969 -** **XXX** S uspension C oncentrate 2.47 Foliar Aerial and ground Cereals, bean and pea legumes, peanuts, pome

and stone fruits, fruiting vegetables, oil seed, root and root and tuberous vegetable crops **BAS 703 01 F Fungicide**  **Reg No. 7969 -** **XXX** S uspension C oncentrate 2.09 (2.09 Pyraclostrobin) Foliar Aerial and ground Pome and stone fruits, fruiting vegetables, oil

seed, soybean, and root and tuberous vegetable crops. **BAS 703 02 F**  **Fungicide Reg No. 7969**  **- XXX**  S uspension C oncentrate 1.39 (2.78 Pyraclostrobin) Foliar Aerial and ground Cereals, fruiting vegetables, oilseed crops,

peanut, soybean, and root and tuber vegetables crops.

###  13

 **Proposed Use Information**  **for Fluxapyroxad Products EUP**  **Crop Max Single**  **App Rate (lbs ai/A)**  **Number of**

**Applications Minim** **um**

**Retreatm ent**  **Interval Max Annual** 

**App Rate (lbs ai/A)**  **Notes**

BAS 700 01F Barley 0.089 2 NS 0.18 1

Corn 0.089 2 7 0.18 1 Dried shelled peas (except soy bean) 0.089 2 7 0.18 1 Dried shelled beans (except soy bean) 0.18 2 7 0.36 1 Edible podded legume vegetables 0.089 2 7 0.18 1 Fruiting vegetables 0.089 3 7 0.27 1 Oat 0.089 2 NS 0.18 1 Oilseed crops, canola/rapeseed 0.089 2 14 0.18 1 Oilseed crops, other 0.089 2 7 0.18 1 Peanut 0.089 3 14 0.27 2 Pome fruits 0.089 4 7 0.36 1 Rye 0.089 2 NS 0.18 1 Soy bean 0.089 2 14 0.18 1 Stone fruits 0.110 3 7 0.33 1 Succulent shelled peas and beans 0.089 2 7 0.18 1 Sugar beet 0.089 3 14 0.27 2 Tuberous and corm vegetables 0.089 3 7 0.27 2 Wheat, triticale 0.089 2 NS 0.18 1

BAS 700 02F and BAS 700 03F Barley seed 0.05 1 NA 0.05 Based on 100 lbs seed/acre

Corn seed 0.013 1 NA 0.013 Based on 25 lbs seed/acre Cotton seed 0.004 1 NA 0.004 Based on 18 lbs seed/acre Dried shelled pea and bean seed 0.016 1 NA 0.016 Based on 160 lbs seed/acre Edible podded legume vegetable seed 0.023 1 NA 0.023 Based on 225 lbs seed/acre Oat seed 0.013 1 NA 0.013 Based on 128 lbs seed/acre Peanut seed 0.014 1 NA 0.014 Based on 135 lbs seed/acre

###  14



**EUP Crop**  **Max Single App Rate**  **(lbs ai/A) Number of** 

**Applications Minim** **um**

**Retreatm ent**  **Interval Max Annual** 

**App Rate (lbs ai/A)**  **Notes** Rye seed 0.015 1 NA 0.015 Based on 150 lbs seed/acre Sorghum seed 0.002 1 NA 0.002 Based on 8 lbs seed/acre Soy bean seed 0.016 1 NA 0.016 Based on 160 lbs seed/acre Sunflower seed 0.02 1 NA 0.020 Based on 100 lbs seed/acre Wheat, triticale seed 0.068 1 NA 0.068 Based on 135 lbs seed/acre

BAS 700 04F Barley 0.087 2 NS 0.17 1

Corn 0.17 1 7 0.17 1, 3 Dried shelled peas (except soy bean) 0.087 2 7 0.17 1 Dried shelled beans (except soy bean) 0.174 2 7 0.35 1 Edible podded legume vegetables 0.087 2 7 0.17 1 Fruiting vegetables 0.087 3 7 0.26 1 Oat 0.087 2 NS 0.17 1 Oilseed crops, canola/rapeseed 0.087 2 14 0.17 1 Oilseed crops, other 0.087 2 7 0.17 1 Peanut 0.087 3 14 0.26 2 Pome fruits 0.087 4 7 0.35 1 Rye 0.087 2 NS 0.17 1 Soy bean 0.087 2 14 0.17 1 Stone fruits 0.108 3 7 0.32 1 Succulent shelled peas and beans 0.087 2 7 0.17 1 Sugar beet 0.087 3 14 0.26 2 Tuberous and corm vegetables 0.087 3 7 0.26 2 Wheat, triticale 0.087 2 NS 0.17 1
BAS 703 01F Fruiting vegetables 0.089 3 7 0.27 1

Oilseed crops, canola/rapeseed 0.089 2 14 0.18 1 Oilseed crops, other 0.089 2 7 0.18 1 Pome fruits 0.089 4 7 0.36 1

###  15



**EUP Crop**  **Max Single App Rate**  **(lbs ai/A) Number of** 

**Applications Minim** **um**

**Retreatm ent**  **Interval Max Annual** 

**App Rate (lbs ai/A)**  **Notes** Soy bean 0.089 2 7 0.18 1 Stone fruits 0.109 3 7 0.32 1 Tuberous and corm vegetables 0.089 3 7 0.27 2 Wheat, triticale 0.089 2 NS 0.18 1

BAS 703 02F Barley 0.087 2 NS 0.17 1

Corn 0.087 2 7 0.17 1 Dried shelled beans (except soy bean) 0.087 2 21 0.17 1 Edible podded legume vegetables 0.087 2 7 0.17 1 Fruiting vegetables 0.087 3 7 0.26 1 Oat 0.087 2 NS 0.17 1 Oilseed crops, canola/rapeseed 0.087 2 14 0.17 1 Oilseed crops, other 0.087 2 7 0.17 1 Peanut 0.087 3 14 0.26 2 Rye 0.087 2 NS 0.17 1 Soy bean 0.087 2 7 0.17 1 Succulent shelled peas and beans 0.087 2 7 0.17 1 Sugar beet 0.087 3 14 0.26 2 Tuberous and corm vegetables 0.087 3 7 0.26 2 Wheat, triticale 0.087 2 NS 0.17 1 NS
- not specified. NA

- not applicable **Notes** 1. Only 2 consecutive applications before alternating to a labeled fungicide w/ different mode of action. 2. Only 1 application before alternating to a labeled fungicide w / different mode of action. 3. Max single use rate based on label footnote in Table 2
. 4. Seeding rates obtained from USEPA mo del TREX Version 1.4.1 (http://www.epa.gov/oppefed1/models/terrestrial/index.htm#trex).

###  16

 **Appendix B TIER I SURFACE WATER MODELING OUTPUT FILES**  **FIRST Output** RUN No. 1 FOR fluxapyroxad ON beans * INPUT VALUES *

-------------------- ------------------------------------------------ RATE (#/AC) No.APPS & SOIL SOLUBIL APPL TYPE %CROPPED INCORP ONE(MULT) INTERVAL Koc (PPM ) (%DRIFT) AREA (IN)

------------------------------------------------------------- ------- 0.180( 0.359) 2 7 931.0 3.4 AERIAL(16.0) 87.0 0.0
FIELD AND RESERVOIR HALFLIFE VALUES (DAYS)

-------------------------------------------------------------------- METABOLIC DAYS UNTIL HYDROLYSIS PHOTOLYSIS METABO LIC COMBINED (FIELD) RAIN/RUNOFF (RESERVOIR) (RES.

- EFF) (RESER.) (RESER.)

-------------------------------------------------------------------- 857.00 2 0.00 0.00
- 0.00 993.00 993.00 UNTREATED WATER CONC (MICROGRAMS/LITER (PPB)) Ver 1.1.1 MAR 26, 2008

-------------------------------------------------------------------- PEAK DAY (ACUTE) ANNUAL AVERAGE (CHRONIC) CONCENTRATION CONCENTRATION

--------------------------------------------------------------------

14.064 6.699
RUN No. 2 FOR fluxapyroxad ON seeds * INPUT VALUES *

--------------------------------------------- ----------------------- RATE (#/AC) No.APPS & SOIL SOLUBIL APPL TYPE %CROPPED INCORP ONE(MULT) INTERVAL Koc (PPM ) (%DRIFT) AREA (IN)

-------------------------------------------------------------------- 0.068( 0.068) 1 1 931.0 3.4 GRANUL( 0.0) 87.0 2.0
FIELD AND RESERVOIR HALFLIFE VALUES (DAYS)

-------------------------------------------------------------------- METABOLIC DAYS UNTIL HYDROLYSIS PHOTOLYSIS METABOLIC COMBINED (FIELD) RAIN/RUNOFF (RESERVOIR) (RES.

- EFF) (RESER.) (RESER.)

-------------------------------------------------------------------- 857.00 2 N/A 0.00

- 0.00 993.00 993.00 UNTREATED WATER CONC (MICROGRAMS/LITER (PPB)) Ver 1.1.1 MAR 26, 2008

-------------------------------------------------------------------- PEAK DAY (ACUTE) ANNUAL AVERAGE (CHRONIC) CONCENTRATION CONCENTRATION

--------------------------------------------------------------------

1.222 0.545

###  17

 **TIER I GROUND W** **ATER MODELING OUTPUT FILE S**  **SCI -**  **GROW Output** SCIGROW VERSION 2.3 ENVIRONMENTAL FATE AND EFFECTS DIVISION OFFICE OF PESTICIDE PROGRAMS U.S. ENVIRONMENTAL PROTECTION AGENCY

SCREENING MODEL FOR AQUATIC PESTICIDE EXPOSURE SciGrow version 2. 3 chemical:fluxapyroxad time is 8/ 1/2011 8:46:30

------------------------------------------------------------------------ Application Number of Total Use Koc Soil Aerobic rate (lb/acre) applications (lb/acre/yr) (ml/g) m etabolism (days)

------------------------------------------------------------------------ 0.180 2.0 0.360 9.02E+02 366.0

------------------------------------------------------------------------ groundwater screening c ond (ppb) = 8.74E
- 02 ************************************************************************ SciGrow version 2.3 chemical:fluxapyroxad time is 8/ 1/2011 8:46:42

------------------------------------------------------------------------ Application Number of Total Use Koc Soil Aerobic rate (lb/acre) applications (lb/acre/yr) (ml/g) metabolism (days)

------------------------------------------------------------------------ 0.068 1.0 0. 068 9.02E+02 366.0

------------------------------------------------------------------------ groundwater screening cond (ppb) = 1.65E
- 02 ************************************************************************

###  18

 **Appendix C. Summar** **y of Maximum Degradate Amounts in Environmental Fate Studies of Fluxapyroxad** 
**Degradate 1**  **Max. Degradate % of Applied (Time of Peak)**

**Hydrolysis Aqueous** 

**Photolysis Soil** 

**Photolysis Aerobic Soil**  **Anaerobic Soil**
**Source MRID** 4 8409101 47923513 47923690 47923684 47923688 NJ (loam) ID (sandy loam) IL (loam) WI (loamy sand) M700F001
-- -- 2.8% (Day 15) **32.6%** (Day 123) 5.7% (Day 362)

-- -- **10.1** % (Day 123) M700F002

-- -- -- -- -- 4.6% (Day 242)

-- -- M700F007

-- -- -- -- -- -- -- -- Unknowns

-- 2.8% (Day 15) 3.2% (Day 2)

-- 1.4% (Day 362)

-- 4.8% (Day 368)

-- Nonextracted residues -- -- 5.1% (Day 15) **28.5%** (Day 368) **11.3%** (Day 362) **17.5%** (Day 242) **39.4%** (Day 368) **38.3** % (Day 123) CO 2 -- -- 1.3% (Day 15) 0.88% (Day 368) 0.52% (Day 362) 5.25% (Day 368) 0.42% (Day 368) 0.4% (Day 123)

**Degradate 1**  **Max. Degradate % of Applied (Time of Peak) Analyzed Degradate** **s (ppm) 4**  **Aerobic Soil Aerobic Aquatic**  **Anaerobic Aquatic TFD**  **TFD TFD**  **Source MRID** 47923691 47923713 47923714 47923695 47923696 47923697

CA (sandy loam) GA (sandy loam) IN (loam) NC (sandy loam) M700F001 0.1% (Day 15) 0.7% (Day 15) 0.1% (Day 28)

-- **10.9** % (Day 43) 2 5.2% (Day 182) 0.003 (Day 7) 0.006

(Day 30) 0.026

(Day 60) M700F002 1.1% (Day 120) 0.4% (Day 120) 2.3% (Day 91)

-- 3.7% (Day 100) 2.5% (Day 365) 0.003 (Day 58) 0.004 (Day

60) 0.009

(Day 60) M700F007

-- -- -- -- 7.5% (Day 57) 2

-- NA5 NA NA Unknowns 1.6% (Day 0) 1.2% (Day 0) 1.6% (Day 28) 1.2% (Day 15) 2% (Day 30) 14.8% (Day 365) 3 Nonextracted residues **10.5%** (Day 120) **24.9%** (Day 120) **15.6%** (Day 120) **25.6%** (Day 120) **21.1** % (Day 57) **15.8 %**  (Day 365) CO 2 0.3% (Day 120) 0.4% (Day 120) 1.5% (Day 120) 0.5% (Day 120) 2.8% (Day 57) 2.8% (Day 365) 1. M700F001: 3
- (difluoro

-methyl)

- 1
-methyl

- 1H
-py razole

- 4
- carboxylic acid M700F002: 3
- (difluoro

-methyl)

- 1H
-pyrazole

- 4
- carboxylic acid M700F007: 3
- (difluoro

-methyl)

- 1
-methyl

- 1H
-py razole

- 4
- carboxamide 2. Formation occurred only under irradiated conditions. Under dark conditions, M700F001 and M700F007 did not form. 3. Unknowns contain multiple components, each accounting for <5% total applied residues. 4. Highest concentrations occurred in top 3 inches of soil. 5. NA

– not analyzed