## UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460 OFFICE OF C HEMI CAL SAFETY ANO POLLUTION PREVENTION 

## MEMORANDUM Date : 22-SEP-2015 

## S ubject: Pyrimethanil: Acute and Chronic Aggregate Dietary (Food and Drinking Water) Exposure and Risk Assessment for the Proposed Uses on Cucumbers , Tomato Subgroup 8- 1 OA, Lemon Subgroup 10-1 OB , Orange S ubgro up 10-1 OA, Grapefruit Subgroup 10-lOC, Pome Fruit Group 11-10, Stone Fruit Group 12-12 Caneberry Subgroup 13-07A, and Bushberry Subgroup 13-07B. PC Co de : 28820 I Decision Nos.: 492391 & 493505 Petition Nos.: 4F829 I 

### & 

### 4E8302 Ri sk Assessment Type: Dietary TXRNo. : NA MRID 

### No.: NA 

### DP No.: 0424861 Reg ist ra tion No.: 438 13-32 Reg ulatory Action: Section 3 

### Case No.: 7059 CAS No.: 53112-28-0 40 

### CFR: §180.518 

## From: George F. Kramer, Ph.D. , Senior Chemist #' 

# :!'¢."**~** Risk Assessment Branch 1 (RAB 1) 

## T hrou gh :

To: Health Effects Division (HED ,

# 750**~** {/_ 

# bv

# ~ . Sheila Piper, Senior Chemist/

## ~**~** '. 

# ;;;1,fr David E. Hrdy , Senior BiologistP twe

# 41..**yjfi R**  Dietary Exposure Science Advisory Council (DESAC HED (7509P) And Thurston G. Morton, Acting Branch Chief RAB 1/HED (7509P) Andrew Ertman/Barbara Madden , RM 05 Marcel Howard/Hope Johnson, RM 21 Registration Division (RD , 7505P) 

## Executive Summary Aggregate (food+ water) acute and chronic dietary exposu re and risk assessments were conducted for the general U.S. population and various popu lation subgroups using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM-FCID) Version 3 .16. 

## This software uses 2003-2008 food consumption data from the U.S. Department of Agriculture ' s (USDA ' s) National Health and Nutrition Examination Survey, What We Eat in America, (NHANES/WWE IA). The analyses were performed to support a Section 3 registration Page I of22

### Pyrimethanil Dietary Exposure and Risk Assessment DP # 424861 

### request for use of the fungicide pyrimethanil [4 , 6-dimethyl-N-phenyl-2-pyrimidinamine] on cucumbers , tomato subgroup 8-1 OA, lemon subgroup 10-1 OB , orange subgroup 10-1 OA, grapefruit subgroup 10-1 OC, pome fruit group 11-10, stone fruit group 12-12 caneberry subgroup 13-07A , and bushberry subgroup l 3 -07B. This memorandum was reviewed by two peer reviewers of the DESAC , per DESAC SOP 2012.1. Acute Dietary Exposure Results and Characterization The unrefined acute assessment assumed that pyrimethanil residues are present in all commodities at to lerance levels and that 100% of all crops are treated ( 100% CT). DEEM Version 7 .81 default processing factors were u sed to estimate residues in processed commodities , as 

### available, and empirical processing factors were used for orange and apple juice. Drinking water was incorporated directly into the dietary assessment using the estimated drinking water concentrations (EDWC s) generated by with the Surface Water Concentration Calculator (SWCC) and Pesticide Root Zone Model-Ground Water (PRZM-GW) provided by the Environmental Fate Effects Division (EFED). Using the DEEM-FCID software, dietary risk at the 95th percentile of exposure is estimated at 10% of the acute population-adjusted dose (aPAD) for the general U . S. population and 40% of the aPAD for children 1-2 years old , the population subgroup with the highest estimated acute dietary exposure . Therefore, the acute dietary ri sk assessment shows that for all included commodities plus drinking water, the acute dietary risk estimates are below HED ' s level of concern for the general popuJation and all population subgroups (i.e. , < 100% aPAD). Chronic Dietary Exposure Results and Characterization The unrefined chronic assessment assumed that pyrimethanil residues are present in all commodities at to lerance levels and that 100% of all crops are treated. DEEM Vers ion 7 .81 default processing factors were used to estimate re s idues in processed commodities , as available, and empirical processing factors were used for orange and applejuice. Drinking water estimates were incorporated directly into the chronic dietary assessment using the EDWC values generated by the SWCC surface water model. Using the DEEM-FCID software, dietary ri sk is estimated at 15% of the chronic populationadjusted dose (cPAD) for the general U.S. population and 80% of the cPAD for children 1to2 years old, the population subgroup with the highest estimated chronic dietary exposure to pyrimethanil. The chronic dietary risk assessment shows that for all included commodities plus drinking water, the chronic dietary risk estimates are below HED ' s level of concern (i.e., < 100% cPAD). Cancer Dietary Exposure Asse ssment A cancer dietary assessment was not conducted because pyrimethanil is classified as " not likely to be carcinogenic to human s at doses that do not alter rat thyroid hormone homeostasis. " Pyrimethanil was previously classified as a Group C carcinogen , but newly submitted toxicology data have resulted in this change in cancer classification (TXR #0056151, J. Rowland , 23-DEC2012) . Page 2 of22

### Pyrimethanil Dietary Exposure and Risk Assessment DP # 424861 

## I. Introduction Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic (non-cancer) assessments , the risk is expressed as a percentage of a maximum acceptable dose (i .e. , the dose which HED has concluded will result in a no-observed adverseeffect level , NOAEL). This dose is referred to as the PAD . The PAD is equivalent to the point of departure (POD , NOAEL, LOAEL) divided by the required uncertainty factors (UFs). For acute and chronic (non-cancer) exposures , HED is concerned when estimated dietary risk exceeds 100% of the PAD for acute and non-cancer chronic assessment. R eferences that discuss dietary risk assessments in more detail are available on the EPA/pesticides web site : " Available Information on Assessing Exposure from Pesticides, A User's Guide ," 21-JUN-2000, web link: http: //www.regu lations.gov/# !documentDetail;D=EPA-HQ-OPP-2007-0780-0001. The most recent dietary risk assessment for pyrimethanil was conducted by J. Pyne (12

-AUG

2014; 0417165) . 

## II. Residue Information Pyrimethanil tolerances are published in 40 CFR 

## § 180.518. 

## Residues of Concern in Plants and Livestock: Table 1 is a summary of the HED Metabolism Assessment Review Committee (MARC) decisions concerning the residues of concern in plants , ruminants , and milk for tolerance expression and risk assessment purposes (J. Morales, 12

-JAN2004; 0248001). Table 1. Re s idues of Concern in Plants and Ruminants . 

### Matrix Residues ofConcern For Risk Assessment For Tolerance Expression Plants Parent Only Parent Only Ruminant Parent + AEC614276 Parent + AEC6 14276 Milk Parent + AEC614277 Parent + AEC614277 

## Recommended Tolerances: The proposed new use to gr eenhouse-grown cucumbers is as a fo liar application three times at 0. 70 lb s ailA with a maximum of 2.1 lb s ailA/season and a preharvest interval (PHI) of 1 day . The proposed new use to caneberries and bushberries is as a foliar application 2-4 times at 0.35-0.70 lbs ai/A with a maximum of 1.4 lb s ai/A/season and a PHI of 1 day. N o new data were submitted to support tolerances on tomato subgroup 8-1 OA , lemon subgroup 10-1 OB , pome fruit grou p 11-10, orange subgroup 10 -1 OA, grapefruit subgroup l 0- 1OC , and stone fruit group 12-12. The petitioner has requested that existing tolerances be expanded to their respective crop gro ups or c r op subgroups. As part of the current petitions , HED recommends establishing the following tolerances: Cucumber .. . .. .. ..... ..... .. .. . .. .. .. .. .. .. .. . ... . ... . ... .. .. .. .. .. .. .. .. .. .. . 1.5 ppm Fruit, c itru s, group 10

- 10 .......................................... . .. . . 10 ppm Fruit, pome , gro up 11-10 .. .. .. .. .. .. .. . ... . ... .. ....................... 15 ppm Fruit, stone , group 12-12 .................... ... ...................... .. 10 ppm Tomato subgroup 8-IOA ... . ... . ... . .. .. .. . ......................... 0.50 ppm Caneberry, subgroup 13-07A ........................ . ... . .. .. .. . ... . 15 ppm Bushberry, subgro up 13 -07B .. .. .. .. .. .. .. .. .. .. .. ...... . .......... 8.0 ppm Page 3 of 22

### Pyrimethanil Dietary Exposure and Risk Assessment DP # 424861 

## Food Residues and processingfactors used in the Acute and Chronic Analysis: The acute and chronic analyses assumed DEEM (ver. 7.81) default processing factors (as necessary), empirical processing factors for orange and applejuice, to lerance-level residues, and 100% CT for all commodities. The empirical processing factors for orange juice (0.007) and apple juice (0.35) can be found in D248001 (PP#s 2F6439 

## & 2F6480, J. Morales , 12-JAN-2004). The tolerance in 40 CFR §180 . 518(a)(1) for residues ofpyrimethanil in/on onion, bulb, subgroup 3-07 A do not match the recommended tolerances from a previous assessment (Memo , Tyler el 

## al., 22-MAY-2013; D389923). HED recommended for a tolerance of0.20 ppm for residues of pyrimethani l in/on onion, bulb, subgroup 3 -07A. Since the 40 CRF has a higher tolerance for residues of pyrimethanil in/on onion, bu lb , subgroup 3-07A, the 40 CFR tolerance of2.0 ppm was used in this assessment to be consistent with the published limits until this revision is accepted. 

## Fish: The USDA Pesticide Data Program (PDP) monitored pesticide residues in catfish in 2008 , 2009, and 2010. Over this 3-year period, PDP analyzed 1,479 samples of catfish for pyrimethanil residues. None of the samples contained detectable residues. As a result, residues in fish were not included in the assessment. 

## III. Percent Crop Treated Information The acute and chronic analyses assumed that 100% of the crops were treated. 

## IV. Drinking Water Data EFED studies indicated that pyrimethanil is expected to be moderately persistent in the environment. Aerobic metabolism is expected to be the major route of degradation for pyrimethanil in the environment. The only major degradate is 2

-amino -4 , 6-dimethylpyrimidine. Although it may be less toxic than the parent, 2-arnino-4,6-dimethylpyrimidin e is expected to be more mobile and more persistent in the environment than the parent. MARC recommended that parent and 2-amino

-4 , 6

-dimethylpyrimidine are the residues of concern for drinking water. EFED provided EDWCs estimated with the SWCC and PRZM-GW using the maximum application rate and number ofapplications , as there are no monitoring data available for use in the human health risk assessment (J. Wolf, 14- MAY-2015; D422295). IR-4 has requested to expand the citrus, pome and stone fruit crops for the existing postharvest uses for PENBOTEC®400 SC (EPA Reg. No. 438 13

-32). Based on the information provided, EFED considers the proposed post-harvest dip use of pyrimethanil as an indoor use that would pose minimal exposure to the environment, provided that release of the chemical and contaminated water are controlled. The screening level drinking water concentrations for combined residues of pyrimethanil (parent 

## + 2-amino-4, 6-dimethylpyrimidine) in surface water are not expected to exceed 156 ppb for the peak 1-in-10-year concentration; 27.9 ppb for the 1-in-10-year annual mean concentration ; and , 21.3 ppb for the 30-year annual average concentration for the new uses or crop group expansion (assuming 2 crops per year 1 ). 

## The screening level drinking water concentrations for combined

1 

### I crop per year - peak 

### 68 μg/ L: 

### annual average = 18 μg/L, 

### and 30 year average = 13 μg/L . 

### Page 4 of22

### Pyrimethanil Dietary Exposure and Risk Assessment DP # 424861 

## residues of pyrimethanil (parent + 2

-amino

-4,6 -dimethylpyrimid ine) in groundwater estimated with PRZM-GW are 

## 128ppb for the highest daily value and 

## 11 7ppb for the post- break-through average (Table 2) . Cun-ent policy is for EFED to recommend the EDWCs for the water source with the highest EDWCs, which for pyrimethanil is surface water for acute exposure and groundwater for chronic exposure. However, due to generally low leaching (EDWCs and incomplete breakthrough) with 100-year simulation in groundwater, the surface water EDWCs are recommended for both acute and chronic exposure assessments. The EDWCs for the combined res idues are presented below in Table 2 . The models and their descr iptions are avai lable at the EPA internet site : http: //www.epa.gov/oppefed I/mode ls/water/.

Ta ble 2. Surface Water a nd Gro undwater EDWCs for Py rim ethan il Plus t he Deg ra date (2-a min o-4,6- d im ethy lpy rimidine) for the Propo sed New Uses a nd C r op G roup Ex p a ns io ns for Scala®SC F un gicide (EPA Reg No. 264-788) Assumi ng the Max imum Aoolication Rate (3 or 6**applicat ons** **~** 

### 0.7 lb a.i./A/year). Standard Scenarios Model App li cation Rate I

-in- I0-Year 30-Year Peak Annual Mean Mean S urface Water #/lb a.i ./ A (ppb) Multiple Scenarios.. r 

## swcc 3 @ 0.7/7 per crop 1569 

### 27.9b 21.3c cycle /2 crop cycles 3 @ 0.717 per crop 67.8d 17.SC 13.1 f 

### cycle / I crop cycles Highest Groundwater Daily Va lue Post-breakthrough Average 

### FL Citrus PRZM

-GW 

### FL Potato 

### • FL Strawberry (2 crop cycles) . b 

### PA Tomato (2 crops cycles). c 

### CA Grape (2 crops cycles). d 

### FL Strawberry (I crop cycle). c 

### PA Apple (I 

### crop cycle). r GA Peach (I crop cycle). 3 @ 0.7/7 per crop 128 117 cvc le /2 crop cycles 3@ 0.7/7 per crop 25.2 22 .7 cycle /2 crop cycles



## J n this assessment, the l-in-10-year annual average surface water concentration (27.9 ppb) and the 1-in- l 0

-year acute peak surface water concentrations (156 ppb) were used for chronic and acute dietary exposure assessments , respectively . 

## V. DEEM-FCID Program and Co nsumption Information Pyri methanil acute and chronic dietary exposure assessments were conducted using the DEEMFCID , Version 3.16, which incorporates 2003-2008 consumption data from USDA's NHANES/WWEIA. The data are based on the reporte d consumption ofmore than 20, 000 indi vidual s over two non-consecutive survey days. Foods "as consumed" (i .e., apple pie) are linked to EPA-defined food commodities (i.e., apples , peeled fruit

- cooked ; fresh or N/ S; baked; or wheat flour

- cooked; fresh or N/S, baked) usin g publi cly available recipe translation files developedjointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S . popu lation and withi n population subgroups, but for acute exposure assessment are retained as individual consumption events . Based on analysis of the 2003 -2008 NHANES/WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants ( < l year old) , children 1-2 years Page 5 of22

### P yrimethanil Dietary Expo sure and Ri sk Assessment DP # 424861 

## old, children 3-5 yea rs old , children 6 -1 2 years old , youth 13 -1 9 years old , adu lts 20-49 years old , females 13-49 years old , and adults 50-99 years old. For the chronic di etary ex posure assessment, an estimate of the residu e le vel in each food or food-form (i.e., orange or orange juice) on the food commodity residue li st is multiplied by the average daily consumption estimate for that food/food form. The resulting re s idue consumption estimate for each food/food form is summed w ith the residue consumption estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Ex posure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for e ach population subgroup. For acute exposure assessments , individual one-day food consumption data are used on an individual-by- individual basis. The reported consumption amounts of each food item can be multiplied by a residu e point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposu re assessment, or " match ed" in multiple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution ofe xposures is expressed as a percentage ofthe 

## aPAD on both a user (i.e. , those who reported eating relevant commodities/food form s) and a per-capita (i.e. , those who reported eating the relevant commodities as well as tho se who did not) bas is . In accordance with HED pol icy, per capita exposure and risk are reported for all levels of refinements. However, for unrefined and partiall y refined assessments , significant differences in u ser vs. per capita exposure and ri sk are identified and noted in the risk assessment. 

## VI. Tox ico logical In formation The toxicology endpoints and decisions made by the HIARC concerning dietary exposure are summarized in Table 3 . Based on toxicol og ical considerations (evaluated by HIARC) and the residue assumptions used in the dietary analy ses (evaluated by the risk assessment team ; RAB l/H ED), it was concluded that the FQPA Safety Factor should be reduced to 1 X when assessing dietary expos ure to pyrimethanil.

Page 6 of22

### Pyrimethanil Dietary Exposure and Risk Assessment DP # 424861 T a b le 3. S umm a ry o f T ox icologica l D oses a nd E ndp o ints for Py rim etha nil fo r Use in Diet a ry Ex p os ure Ri s k A ssessm e nts . Exposure/ POD Uncerta inty / FQPA RID , PAD, Level of Study and Toxicological Effects Scenario Safety Factors Concern Acute Dietary NOAEL= UFA= IOX 

### Acute RID = 0.45 Dev e lo pm e nta l Tox ic ity - R a bb it : (Females 13- 45 UFH = IOX 

### mg/kg/day LOAEL = 300 mg/kg/day based on 49 years of mg/kg/day FQ P A SF = I X 

### increases in fetuses w it h 13 thorac ic age) aPAD = 0.45 vertebrae and 13 pairs of ribs. mg/kg/day Acute Dietary NOAEL = UFA = !OX 

### Acute RID = I 

### Acute Ne uroto xic ity- Rat : (General 100 UFH = IOX 

### mg/kg/day LOAEL = I000 mg/kg/day based on Popu l ation, mg/kg/day FQPA SF= IX 

### decreased motor activ ity , atax ia, including decreased body t em perature, hind Infants and limb grip strength, and dilated pupi ls. Children) Chronic NOAEL = UFA = IOX 

### Chronic 

### RfD = 0.17 C hronic T o xicity - R a t: Dietary (All 17 UFH = IOX 

### mg/kg/day LOAEL = 221 mg/kg/day based on Populations) mg/kg/day FQ PA SF = lX 

### decreased body weight gains; cPAD = 0.17 increased serum cholesterol and mg/kg/day GGT , increased relative li ver/body weight ratios, necropsy and hi

stopatho logical findings in the liver and thyroid . Cancer (oral, denna l, In accordance w ith the EPA's 

### Final Guidelines for Carcinogen Risk Assessment inhalation) (Ma rch 2005), the CARC classified pyrimethani l as " not li ke ly to b e ca rcino ge nic t o hum a n s a t d oses tha t do not alter r a t thy roid ho rmon e ho m e os tas is " (T XR# 

### 005615 1, 

### J. Rowland, 23-DEC-2012) . Pomt of departu re (POD) = A data point or an estimated po i nt that is derived from observed dose

-response data and u sed to mark the beginning of extrapo lation to determ ine risk associated with lower environmentally r e levant human exposures. NOAEL = no-observed adverse

- effect level. LOAEL = lowest

-observed adverse-effect level. UF = uncertainty factor. UFA = extrapolation from animal to human (intraspecies). UFH = potentia l variation in se nsitivity among members of the human population (interspecies) . FQPA SF = FQPA Safety Factor. PAD= population-adjusted dose (a = acute, c = chronic). 

### RfD = reference dose. MOE = margin of exposure. 

## VII. R es ults/Di scussion As stated above , for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the aPAD or cPAD, respectively . The fo ll owi ng paragra phs are s umma ries of the DEEM

-FC ID (ver. 3. 16) acute and ch ro nic exposure analyses . Acute and chronic aggregate (food+ wate r ) analyses were performed using DEEM-FCID estimating the dietary exposure of the U.S. population and various populati on subgroups. The results are summarized in Tab le 4 below for ac ute and chronic analyses . The resulting acute food and drinking water risk estimates are not of concern to HE D (< I 00% aPAD) at the 95 111 

## percentil e of the exposure distribution fo r the U.S. general popul atio n and al l population subgroups (:S40% aPAD ); the most highly exposed population s ubgro up is children 1

- 2 years old. The resulting chronic food and drinking water risk estimates are not of concern to HED (< 1 00% cPAD) for U.S. general population and all populati o n subgro up s (:S80% cPAD); the most highly exposed pop ul ation subgroup is children 1-2 years old.

Page 7 of22

### Pyrimethanil Dieta ry Exposure and Ri sk Assessment DP# 424861 T ab le 4. S umm a ry o f Dietary ( f ood a nd Drin kin g Wa ter) Ex p os ure and R is k fo r Pyrim etha n il. 

## * Acute Dietary Chronic Dietary Cancer (95th Percentile) Population Subgroup Dietary Di etary Dietary Exposure %a PAD * Expos ure %c PAD * Exposure Ri sk ( mg/kg/d ay) ( mg/kg/day) (mg/kg/day) General U.S. Po pul ation 0.105357 11 0.024977 15 A ll In fants (< I year o l d) 0.369251 37 0.090488 53 C h ild re n 1-2 years old 0.40 1904 40 0. 136305 80 Ch ildren 3 -5 years old 0.254739 25 0.082594 49 Children 6 -1 2 years old 0.137476 14 0.038145 22 NIA NIA 

### Youth 13

- 19 years o ld 0.065147 6.5 0.016025 9.4 Adults 20-49 years old 0.060961 6.1 0.0 14440 8.5 Adults 50-99 vears old 0.063998 6.4 0.017030 10 Females 13

-49 years o ld 0.063604 14 0.015479 9.1 * Population sub group with the highe st exposure and ri sk is in b o ld typ e. The aPAD for fema l es 13-49 years ofage i s 0.45 m g/kg/day: aP 

### AD for general popu l ation is I 

### mg/kg/day . 

## VIII . C h a r acte r ization of Inputs/Outputs The acute and chronic dietary exposure and risk estimates are conservative since they assume that I 00% ofcrops are treated with pyrimethanil and that re sidue s are present at tolerance leve ls. In addition, drinkin g water exposure estimates we re based on screening leve l es timate s generated by the PRZMIEXAMS water model. Dietary ex po sure estimates cou ld be refined through the use of anticipated residu es and percent crop treated data, as well as refi ned estimate d drinking water concentration s. However, s ince estim at ed expo sures and ri sks using con servative ass umptions are well below HED 's level ofconcern , such re finement is not warranted. 

## IX . Co nclu s ion s The unrefin ed dietary exposure assessment using DEEM-FC ID indi cat es that both acute and c hronic dietary food + drinking water exposures to pyrimethanil are below HED 's level of concern for thi s pes ticid e . Th e res ulting acute food and drinking water ri sk est imates are < 100 % aPAD at the 95 111 

## percenti le of the exposure fo r the U .S. general populatio n and all popu lation subgro ups (::;40% aPAD); the most hi ghly ex po sed population subgroup is children 1-2 years o ld . The chronic food and drinking water ri sk estimates are < 100% c PA D for U.S. general population and al l population subgroups (:S80% cPAD); the most highly exposed population subgroup is children 1-2 years old . 

## X. L ist of Attachments Attachment 1 : Acu te Food p lus Water Resi due In put File Attachme nt 2: Acute Results (Food plus Water ) Fi le Attachment 3: C hroni c Food plus Water Res idue Input File Attachment 4: C hroni c Results (Food plu s Water) Fil e Attachment 5: Acute R esu lt s (Food onl y) Fi le Attachment 6: Chronic Results (Food on l y) File

cc: G. Kramer RD!: DE SAC Reviewers (28- MAY-2015) G. F. Kramer : S I0957:PY-S:(703)305-5079:7509P:RAB I P

age 8 of22

### Pyrimethanil Dietar y Exposure and Risk Assessment DP# 424861 

## Attac hm en t 1 : D EEM-F CID Acute Res idue File - Fo od plus Water Filename : C : \Users\gkramer\Documents\Gk\#Pyrimethanil\Pyrimethanilacute . R08 Chemical : Pyrimethanil RfO(Chronic) : . 17 mg/kg bw/day NOEL(Chronic) : 17 mg/kg b w/day RfO(Acute) : 1 mg/kg bw/day NOEL(Acute) : 100 mg/kg bw/day Date created/last modified : 05-28-2015/09 : 55 : 51 Program ver . 3 . 16 , 03-08-d Comment : FQPA SF lX for all endpoints ; cPAD for all popu l ations is 0 . 17 mg/kg/day EPA Code Crop Grp Commodity Name 0101168000 lAB Ginseng , dried 01030 15000 lCO Arrowroot , flour Fu ll comment : 0284001 0103015001 lCO Arrowroot , flour-babyfood Fu l l comment : 0284001 0103017000 lCO Artichoke, Je rusalem Full comment : 0284001 0103082000 lCO Cassava Full comment : 0284001 0103082001 lCO Cassava-babyfood Full comment : D284001 0103139000 lCO Oasheen , corm Fu ll comment : 0284001 0103166000 lCO Ginger Full comment : 0284001 0103166001 lCD Ginger

- babyfood Full comment : 0284001 0103 16 7000 lCO Ginger , dried Ful l comment : 0284001 0103296000 lC Potato , chips Full comment : 0284001 0 1 03297000 lC Potato , dry (granules/ flakes) Full comment : 0284001 0103297001 lC Potato , dry (granules/ flakes)

- b Full comment : 0284001 0103298000 lC Potato , flour Fu ll comment : 0284001 0103298001 lC Potato , flour-babyfood Full comment : D284001 0103299000 lC Potato , tuber , w/pee l Full comment : 0284001 0103299001 lC Potato , tu ber , w/peel-babyfood Full comment : 0284001 0103300000 lC Po tato , tuber , w/o peel Full comment : 0284001 0103300001 lC Potato , tuber , w/o peel-babyfood Full comment : 0284001 0103366000 lCO Sweet potato Full comment : 0284001 0103366001 lCD Sweet potato-babyfood Full comment : 0284001 0103371000 lCD Tanier , corm Ful l comment : D284001 0103387000 lCO Turmeric Fu ll comment : 0284001 0103406000 lCO Yam , true Full comment : 0284001 0103407000 lCD Yam b ean Full comment : D284001 0301165000 3A Garlic , bulb 0301165001 3A Garlic , bulb

- babyfood 0301237000 3A Onio n, bulb Full comment : 0284001 0301237001 3A Onion , bulb

- babyfood Full comment : 028400 1 0301238000 3A Onion , bulb , dried Full comment: 0284001 0301238001 3A Onion , bulb , dried-babyfood Def Res (ppmJ 1 . 500000 0 . 050000 0 . 050000 0 . 050000 0 . 050000 0 . 050000 0 . 050000 0 . 050000 0 . 050000 0 . 050000 0 . 050000 0 . 050000 0 . 050000 0 . 050000 0 . 050000 0 . 050000 0 . 050000 0 . 050000 0 . 050000 0 . 050000 0 . 050000 0 . 050000 0 . 050000 0 . 050000 0 . 050000 2 . 000000 2 . 000000 2 . 000000 2 . 000000 2 . 000000 2 . 000000 

### Page 9 of22 Adj . Factors Comment #1 #2 1. 000 1. 000 1 . 000 1 . 000 028400 1 . 000 1. 000 028400 1 . 000 1. 000 028400 1 . 000 1 . 000 028400 1 . 000 1 . 000 028400 1 . 000 1 . 000 D28400 1 . 000 1 . 000 028400 1 . 000 1 . 000 028400 1 . 000 1 . 000 028400 1 . 000 1 . 000 028400 6 . 500 1 . 000 028400 6 . 500 1 . 000 028400 6 . 500 1 . 000 028400 6 . 500 1 . 000 028400 1 . 000 1 . 000 028400 1 . 000 1 . 000 028400 1 . 000 1 . 000 028400 1 . 000 1 . 000 028400 1 . 000 1. 000 028400 1 . 000 1 . 000 028400 1 . 000 1 . 000 028400 1 . 000 1 . 000 028400 1 . 000 1 . 000 028400 1 . 000 1 . 000 D28400 1. 000 1. 000 1. 000 1. 000 1 . 000 1 . 000 028400 1 . 000 1 . 000 028400 9 . 000 1 . 000 028400 9 . 000 1 . 000 028400

### Pyrimethanil Dietary Exposure and Ri sk Assessment DP # 42486 1 Full comment : 0284001 0301338000 3A Shallot , bulb 2 . 000000 1 . 000 1 . 000 0302103000 38 Chive , fresh leaves 3 . 000000 1 . 000 1 . 000 0302198000 38 Leek 3 . 000000 1 . 000 1 . 000 0302239000 38 Onion , green 3 . 000000 1 . 000 1 . 000 02S 400 F

ul l comment : 0284001 0302338500 38 S hallot , fres h leaves 3 . 000000 1 . 000 1 . 000 080137 4000 SA Tomatillo 0 . 5000 00 1 . 000 1 . 000 0801375000 SA Tomato 0 . 500000 1 . 000 1 . 000 02S400 Full comment : 02S4001 0801375001 SA Tomato-babyfood 0 . 500000 1 . 000 1 . 000 028400 Full comment : 0284001 0801376000 SA Tomato , paste 0 . 500000 5 . 400 1 . 000 028400 Full comment : 0284001 0801376001 BA Tomato , paste-babyfood 0 . 500000 5 . 400 1 . 000 028400 Full comment : 0284001 OS01377000 SA Tomato , puree 0 . 500000 3 . 300 1 . 000 028400 Full comment : 02S400 1 OS01377001 SA Tomato , puree- babyfood 0 . 500000 3 . 300 1 . 000 028 4 00 F

ull comment : 02S 4001 OS01378000 BA Tomato , dried 0 . 500000 14 . 300 1 . 000 028 4 00 Full comment : 02S 4001 0801378001 BA Tomato , dried

- babyfood 0 . 500000 14 . 300 1 . 000 02B400 Full comment : 02B4001 0801379000 SA Tomato , juice 0 . 500000 1 . 500 1 . 000 02S400 Full comment : 0284001 OS013SOOOO SA Tomato , Tree 0 . 500000 1 . 000 1.000 0902135000 98 Cucumber 1 . 500000 1 . 000 1 . 000 1001106000 lOA Citron 10 . 000000 1 . 000 1 . 000 028400 Full comment : 02B4001 1001107000 lOA Citrus hybrids 10 . 000000 1 . 000 1 . 000 D28400 F

ull comment : 02B 4001 lOOllOSOOO lOA Citrus , oil 150 . 000000 1 . 000 1 . 000 D28400 Full comment : D2B 4001 1001240000 lOA orange 10 . 000000 1 . 000 1 . 000 D2S400 Full comment : 02S4001 1001241000 lOA Orange , juice 10 . 000000 0 . 007 1.000 02S400 Full comment : D284001 1001241001 lOA Orange , juice

- babyfood 10 . 000000 0 . 007 1 . 000 D28400 Full comment : 0284001 1001242000 lOA Orange , peel 10 . 000000 1 . 000 1 . 000 02S400 Full comment : 0284001 1001369000 lOA Tangerine 10 . 000000 1 . 000 1 . 000 02S400 F

ull comment : 02S4001 1001370000 l OA Tangerine , j u ice 10 . 000000 2 . 300 1 . 000 02S 4 00 F

ull comment : 02S 4 00 1 1002197000 lOB Kumquat 10 . 000000 1 . 000 1 . 000 02S 4 00 Full comment : 02B4001 1002199000 lOB Lemon 10 . 000000 1 . 000 1 . 000 SE7353 Full comment : 8E7353 Proposed Tolerance 2009 1002200000 108 Lemon , juice 10 . 000000 2 . 000 1 . 000 SE7353 Full comment : 8E7353 Proposed Tolerance 2009 1002200001 108 Lemon , juice

- baby food 10 . 000000 2 . 000 1 . 000 8E7353 Full comment : 8E7353 Proposed Tolerance 2009 1002201000 lOB Lemon , peel 10 . 000000 1 . 000 1 . 000 8E7353 Full comment : 8E7353 Proposed Tolerance 2009 1002206000 108 Lime 10 . 000000 1 . 000 1 . 000 D2B400 F

ull comment : D2B4001 1002207000 lOB Lime , juice 10 . 000000 2 . 000 1 . 000 D2B400 F

ull comment : D2S4001 1002207001 lOB Lime , juice

- babyfood 10 . 000000 2 . 000 1 . 000 D2B400 Full comment : D2B4001 10031SOOOO lOC Grapefruit 10 . 000000 1 . 000 1 . 000 02S400 Full comment : 0284001 1003181000 lOC Grapefruit , juice 10 . 000000 2 . 100 1 . 000 028400 Full comment : 0284001 1003307000 lOC Pummelo 10 . 000000 1 . 000 1 . 000 028400 Full comment : 0284001 1100007000 

### 11 Apple , fruit w ith peel 15 . 000000 1 . 000 1 . 000 DPH 34 F

ull comment : DP# 3 472 4B llOOOO S OOO 11 Apple , peeled f rui i: 15 . 00000 0 1 . 000 1 . 000 DP # 3 4 

### Page 10 of22Py rim ethanil Dietary Exposure and Ri sk As s essment 

### DP# 424861 Fu l l comment : DP # 3 472 4 8 1100008001 11 Apple , peeled frui t - b abyfood 15 . 000000 1 . 000 1 . 000 DP# 3 4 F

ull comment : DP# 347248 1100009000 11 Apple , dried 15 . 000000 8 . 000 1 . 000 DP# 34 Full comment : DP# 3472 4 8 1100009001 11 Apple , d ried-b a byfood 15 . 000000 8 . 000 1. 000 DP# 34 Full comment : DP# 3472 4 8 1100010000 11 Apple , jui ce 15 . 000000 0 . 350 1 . 000 DPli 34 F

ull comme nt : DP# 3472 4 8 1100010001 11 Apple , j ui ce-b a byfood 1 5 . 000000 0 . 350 1 . 000 DPll 34 F

ull comme nt : DP# 347248 1100011000 1 1 Apple , sauce 15 . 000000 1 . 000 1 . 000 DP # 3 4 Full comment : DPli 3 47248 110001100 1 11 Appl e , sauce -b abyfood 15 . 000000 1 . 000 1 . 000 DP li 34 Fu ll comment : D P# 3472 4 8 1100129000 11 Crabapple 15 . 000000 1 . 000 1 . 000 DP # 34 Fu l l comment : DP# 3 472 4 8 1100210000 11 Loquat 15 . 000000 1 . 000 1 . 000 DP # 34 Full commen t : DP# 3472 4 8 1100266000 11 Pear 15 . 000000 1 . 000 1 . 000 DP # 34 F

ull comme nt : DP# 347248 1100266001 11 Pe ar -bab yfood 15 . 000000 1 . 000 1 . 000 DP# 3 4 Full comment : DP# 347248 1100267000 11 Pear , dried 15 . 000000 6 . 250 1 . 000 DP # 3 4 Full comment : DP # 347248 1100268000 11 Pear , juice 15 . 000000 1 . 000 1 . 000 D P# 34 Full comment : DP# 347248 1100268001 11 Pear , juice-babyfood 1 5 . 000000 1.000 1 . 000 DP # 3 4 Fu l l comment : DP # 3 472 4 8 1100310000 11 Quince 15 . 000000 1 . 000 1 . 000 DP# 34 Full comment : DP# 3472 4 8 1201090000 12A Cherry 10 . 000000 1 . 000 1 . 000 8E7353 Fu l l comment : 8E7353 Proposed Tolerance 2009 1201090001 12A Cherry

- bab yfoo d 1 0 . 000000 1 . 000 1 . 000 8 E 73 53 Full comment : 8E7353 Proposed Tolerance 2009 1201091000 12A C h erry , juice 10 . 000000 1 . 500 1 . 000 8E 7353 F

ull comment : 8E7353 Proposed Tolerance 2009 1201091001 12A Che rr y , juice-babyfo od 10 . 000000 1 . 500 1 . 000 8E7353 Full comment : 8E7353 Prop o s ed Tole r ance 2009 1202012000 128 Apricot 10 . 000000 1 . 000 1 . 000 8E7353 Full comment : 8E7353 Proposed Tolerance 2009 1202012001 128 Apricot

- babyfood 10 . 000000 1 . 000 1 . 000 8E7353 Fu ll comme n t : 8E 7353 Proposed Tolerance 2009 1202013000 1 2B Apricot , dried 10 . 000000 6 . 000 1 . 000 8E7353 F

ull comme nt : 8E7353 Pr oposed Toleran ce 2009 1202014000 128 Apricot , juice 10 . 000000 1 . 000 1 . 000 8 E 7353 Full comment : 8E7353 Proposed Tolera nce 2009 1202014001 12B Apricot , juice

- ba b yfood 10 . 000000 1 . 000 1 . 000 8E7353 F

ul l comment : 8E7353 P ro posed Tolerance 2009 1202230000 12B Nect arine 10 . 000000 1 . 000 1 . 000 8E7353 Full comment : 8E7353 P ro posed Tolerance 2009 1202260000 12B Peach 10 . 000000 1 . 000 1 . 000 8E7353 Fu l l comment : 8E7353 P ro posed To l erance 2009 1202260001 12B Peach

- babyfood 10 . 000000 1 . 000 1 . 000 8E7353 Full comment : 8E7353 Propose d To l e r ance 2009 1202261000 12B Peach , dried 10 . 000000 7 . 000 1 . 000 8 E 7353 Fu l l comment : 8E7353 Proposed To l e r ance 2009 1202261001 128 Peach , dried

- b abyf ood 10 . 000000 7 . 000 1 . 000 8E7353 Full comment : 8E 7353 Proposed Tolerance 2009 1202262000 12B Peach , juice 10 . 000000 1 . 000 1 . 000 8 E 7353 Full comment. : 8E 7353 Proposed Tolerance 2009 1202262001 1 2B Peach , j ui ce - babyfood 10 . 000000 1 . 000 1 . 000 8E7353 Full comme n t : 8E7353 Pr oposed Tolerance 2009 1203285000 1 2C Plum 10 . 000000 1 . 000 1 . 000 8E7353 Full comment : 8E7353 P r o posed Tolerance 2009 1203285001 12C Plum-baby food 10 . 000000 1 . 000 1 . 000 8E7353 Full comment : 8E7353 Proposed Tolerance 2009 1203286000 12C Plum , prune , fresh 10 . 000000 1 . 000 1 . 000 8E7353 Full comment : 8E7353 Proposed To l erance 2009 1203286001 12C Plum , prune , fresh- b abyfood 10 . 000000 1 . 000 1 . 000 8E7353 F

u ll comment : 8E7353 Proposed Tolerance 2009 

### Page 11 of 22

### Pyrimethan il Dietary Exposure and Ri sk Assessment DP# 424861 1203287000 12C Plum , prune , dried 10 . 000000 5 . 000 1 . 000 8E7353 Full comment : 8£7353 Proposed Tolerance 2009 1203287001 12C Plum , prune , dried-babyfood 10 . 000000 5 . 000 1 . 000 8E7353 Full comment : 8£7353 Proposed Tolerance 2009 1203288000 12C Plum , prune , juice 10 . 000000 l. 400 1 . 000 8E7353 Full comment : 8£7353 Proposed Tolerance 2009 1203288001 12C Plum , prune , j u ice

- babyfood 10 . 000000 1. 400 1 . 000 8£7353 Full comment : 8E7353 Proposed Tolerance 2009 1301055000 13A Blackberry 15 . 000000 1 . 000 1 . 000 1301056000 13A Blackberry , juice 15 . 000000 1.000 1 . 000 1301056001 13A Blackberry , juice-babyfood 15 . 000000 1 . 000 1 . 000 1301058000 13A Boysenberry 15 . 000000 1 . 000 1 . 000 1301208000 13A Loganberry 15 . 000000 1 . 000 1 . 000 1301320000 13A Raspberry 15 . 000000 1 . 000 1 . 000 1301320001 13A Raspberry-babyfood 15 . 000000 1 . 000 1 . 000 1301321000 13A Raspberry , juice 15 . 000000 1 . 000 1 . 000 1301321001 13A Raspberry , juice

- babyfood 15 . 000000 1 . 000 1 . 000 1302057000 13B Blueberry 8 . 000000 1 . 000 1 . 000 1302057001 1 3B Blueberry-babyfood 8 . 000000 1 . 000 1 . 000 1302 136000 13B Currant 8 . 000000 1 . 000 1 . 000 1302 137000 13B Currant , dried 8 . 000000 1 . 000 1 . 000 1302149000 13B Elderberry 8 . 000000 1 . 000 1 . 000 1302174000 13B Gooseberry 8 . 000000 1 . 000 1 . 000 1302191000 13B Huckleberry 8 . 000000 1 . 000 1 . 000 1304175000 130 Grape 5 . 000000 1 . 000 1 . 000 028400 Full comment : 0284001 1304176000 130 Grape , jui ce 5 . 000000 1 . 200 1 . 000 028400 E'ull comment : 0284001 1304176001 130 Grape , juice -babyfood 5 . 000000 1 . 200 1 . 000 028400 Full comment : 0284001 1304179000 130 Grape , wine and sherry 5 . 000000 1 . 000 1 . 000 028400 Full comment : 028400 1 1307130000 13G Cranberry 3 . 000000 1 . 000 1 . 000 1307130001 13G Cranberry-babyfood 3 . 000000 1.000 1 . 000 1307131000 13G Cranberry , dried 3 . 000000 1 . 000 1 . 000 1307132000 13G Cranberry , juice 3 . 000000 1 . 100 1 . 000 1307132001 13G Cranberry , juice-babyfo od 3 . 000000 1 . 100 1 . 000 1307359000 13G Strawberry 3 . 000000 1 . 000 1 . 000 028400 Full comment : 0284001 1307359001 13G Strawberry-babyfood 3 . 000000 1 . 000 1 . 000 028400 Full comment : 0284001 1307360000 13G Strawberry , juice 3 . 000000 1 . 000 1 . 000 028400 Full comment : 0284001 1307360001 13G Strawberry , juice

- babyfood 3 . 000000 1 . 000 1 . 000 028400 F

u ll comment : 0284001 1400003000 14 Almond 0 . 200000 1 . 000 1 . 000 028400 Full comment : 0284001 1400003001 14 Almond-babyfood 0 . 200000 1 . 000 1 . 000 028400 Full comment : 0284001 1400004000 14 Almond , oil 0 . 200000 1 . 000 1 . 000 028400 Full comment : 0284001 1400004001 14 Almond , oil

- babyfood 0 . 200000 1 . 000 1 . 000 028400 Full comment : 0284001 1400282000 14 Pistachio 0 . 200000 1 . 000 1 . 000 3100044000 31 Beef , meat 0 . 010000 1 . 000 1 . 000 028400 Full comment : 0284001 3100044001 31 Beef , meat-babyfood 0 . 010000 1 . 000 1 . 000 028400 Full comment : 0284001 31000 45000 31 Beef , meat , dried 0 . 010000 1 . 920 1 . 000 028400 Full comment : 0284001 3100046000 31 Beef , meat byproducts 0 . 010000 1.000 1 . 000 028400 Full comment : 0284001 3100046001 31 Beef , meat byproducts-babyfood 0 . 010000 1 . 000 1 . 000 028400 Full comment : 0284001 3100047000 31 Beef , fat 0 . 010000 1 . 000 1 . 000 028400 Full comment : 0284001 3100047001 31 Beef, fat -babyfood 0 . 010000 1 . 000 1 . 000 028400 Full comment : 0284001 

### 3100048000 31 Beef , kidney 

### 2 . 500000 1 . 000 1 . 000 DP ff 

### 34 Full comment : DP ff 347248 31000 49000 31 Beef , liver 0 . 010000 1 . 000 1 . 000 028400 

### Page 1 2of22

### Pyrimethanil Dietary Exposure and Ri sk Assessment DP# 424861 Full comment : D284001 3100049001 31 Beef, liver

- babyfood 0 . 010000 1 . 000 1 . 000 D28400 Full comment : D284001 3200169000 32 Goat , meat 0 . 010000 1 . 000 1 . 000 D28400 Full comment : D284001 3200170000 32 Goat , meat byproducts 0 . 010000 1 . 000 1 . 000 D28400 Full comment : D284001 3200171000 32 Goat , fat 0 . 010000 1 . 000 1 . 000 D28400 Full comment : D284001 3200172000 32 Goat , kidney 2 . 500000 1 . 000 1 . 000 DP# 34 Full comment : DP# 347248 3200173000 32 Goat , liver 0 . 010000 1 . 000 1.000 D28400 Full comment : 0284001 3300189000 33 Horse , meat 0 . 010000 1 . 000 1.000 D28400 Full comment : D284001 3500339000 35 Sheep , meat 0 . 010000 1 . 000 1 . 000 D28400 Full comment : D284001 3500339001 35 Sheep , meat-baby food 0 . 010000 1 . 000 1 . 000 D28400 Full comment : D284001 3500340000 35 Sheep , meat byproducts 0 . 010000 1 . 000 1 . 000 028400 Full comment : D284001 3500341000 35 Sheep , fat 0 . 010000 1 . 000 1 . 000 D28400 Full comment : D284001 3500341001 35 Sheep , fat-babyfood 0 . 010000 1 . 000 1 . 000 D28400 Full comment : D284001 3500342000 35 Sheep , kidney 2 . 500000 1 . 000 1 . 000 DP# 34 Full comment : DP!I 347248 3500343000 35 Sheep , liver 0 . 010000 1 . 000 1 . 000 D28400 Full comment : D284001 3600222000 36 Milk , fat 0 . 050000 1 . 000 1 . 000 DP# 34 Full comment : DP# 347248 3600222001 36 Milk , fat-baby food/ i nfant formu 0 . 050000 1 . 000 1 . 000 DP# 34 Full comment : DP# 347248 3600223000 36 Milk , nonfat solids 0 . 050000 1 . 000 1 . 000 DP# 34 Full comment : DP# 347248 3600223001 36 Milk , nonfat solids-baby food/in 0 . 050000 1 . 000 1 . 000 DP!I 34 Full comment : DP# 347248 3600224000 36 Milk , water 0 . 050000 1 . 000 1 . 000 DP# 34 Full comment : DP# 347248 3600224001 36 Milk , water - babyfood/infant form 0 . 050000 1 . 000 1 . 000 DP# 34 Full comment : DPll 347248 3600225001 36 Milk , sugar (lactose)

- baby food/ 0 . 050000 1 . 000 1 . 000 DP# 34 Full comment : DP!t 347248 8601000000 86A Water , direct , all sources 0 . 156000 1 . 000 1 . 000 8602000000 868 Water , indirect , all sources 0 . 156000 1 . 000 1 . 000 9500023000 0 Banana 0 . 100000 1 . 000 1 . 000 9500023001 0 Banana-babyfood 0 . 100000 1 . 000 1 . 000 9500024000 0 Banana , dried 0 . 100000 3 . 900 1 . 000 9500024001 0 Banana , dried

- babyfood 0 . 100000 3 . 900 1 . 000 9500177000 0 Grape , leaves 5 . 000000 1 . 000 1.000 D28400 Full comment : D284001 9500178000 0 Grape , raisin 8 . 000000 1 . 000 1 . 000 028400 Full comment : D284001 9500283000 0 Plantain 0 . 100000 1 . 000 1 . 000 9500284000 0 Plantain , dried 0 . 100000 3 . 900 1 . 000 9500289000 0 Pomegranate 5 . 000000 1 . 000 1 . 000



### Page 13 of22

### Pyrimethanil D ietary Expo sure and Risk As ses sm ent DP# 424861 

## Attachment 2: D EEM-F CID Acute Ex pos ure and Ri sk Estima tes - Food plu s Water US EPA DEEM-FCID ACUTE Analysis for PYRIMETHANIL Residue file : Pyrimethanilacute . R08 Analysis Date : 05-28-2015/11 : 07 : 24 Residue NOEL (Acute) = 100 . 000000 mg/kg body

- wt/day RAC/FF intake sununed over 24 hours Ver . 3.18, 03

- 08

- d NHANES 2003

- 2008 2

- Day Adju stment factor #2 used . file dated : 05

- 28

- 2015/09 : 55 : 51 Run Comment : " FQPA SF lX for al l endpoints ; cPAD for all populations is 0 . 17 m g/kg/day " 

### ========================================================== =========== ========== Summary calculations

-- per capita : 95th Percentile---- 99th Percentile---- ---99 . 9th Percentile---- Exposure % aRfD MOE Exposure % aRf D MOE Exposure % aRfD MOE



## ---------- 

## --- ---- -------- 

# ---------- --- ---- -------- 

## ---------- ------ - 

## -------- Total 

### us Population : 10 .54 949 0 . 241985 24 . 20 413 0 . 518749 51 . 87 192 All Infants : 0 . 369251 36 . 93 270 0 . 556543 55 . 65 179 0 . 730604 73 . 06 136 Children 1-2 : 0 . 401904 40 . 19 248 0 . 623436 62 . 34 160 0 . 983385 98 . 34 101 Children 3

- 5 : 0 . 254739 25 . 47 392 0 . 366443 36 . 64 272 0 . 560416 56 . 04 178 Children 6-12 : 0 . 137476 13 . 75 727 0 . 234474 23 . 45 426 0 . 380739 38 . 07 262 Youth 13

- 19 : 0 . 065147 6 . 51 1534 0 . 121471 12 . 15 823 0 . 260931 26 . 09 383 Adults 20-49 : 0 . 060961 6 . 10 16 40 0 . 105701 10 . 57 946 0 . 196827 19 . 68 508 Adults 50

- 99 : 0 . 063998 6 . 40 1562 0 . 100934 10 . 09 990 0 . 179775 17 . 98 556 Female 13

- 49 : 0 . 063604 6 . 36 1572 0 . 108084 10 . 81 925 0 . 235738 23 . 57 424



### Page 14 of22

### Pyrimethanil Dietary Exposure and R isk Assessment DP # 424861 

## Attachment 3: DEEM-FCID Chronic Res idue File - Food plus Water Filename : C : \Users\gkramer\Documents\Gk\ff Pyrimethanil\Pyrimethanilc h ronic . R08 Chemical : Pyrimethanil RfD(Chronic) : . 17 mg/kg bw/day NOEL(Chronic) : 17 mg/kg bw/day RfD(Acute) : 1 mg/kg bw/day NOEL(Acute) : 100 mg/kg bw/day Date created/last modi fied : 05-28-2015/09 : 57 : 00 Program ver . 3 . 16 , 03-08-d Comment : FQPA SF lX for all endpoints ; cPAD for all populations is 0 . 17 mg/kg/day EPA Code Crop Grp Commodity Name Def Res (ppm) Adj . Factors Comment #1 #2 0101168000 lAB Ginseng , dried 0103015000 lCD Arrowroot , flour 1 . 500000 1 . 000 1 . 000 0 . 050000 1 . 000 1 . 000 028400 Full comment : 0284001 0103015001 lCO Arrowroot , flour

- babyfood Full comment : 0284001 0103017000 lCO Artichoke , Jerusalem 0 . 050000 1 . 000 1 . 000 028400 0 . 050000 1 . 000 1 . 000 028400 Full comment : 0284001 0103082000 lCO Cassava 0 . 050000 1 . 000 1 . 000 028400 Ful l comment : 0284001 0103082001 lCD Cassava-babyfood Full comment : 0284001 0103139000 lCD Dasheen , corm Full comment : 0284001 0103166000 lCD Ginger 0 . 050000 1 . 000 1 . 000 028400 0 . 050000 1 . 000 1 . 000 028400 0 . 050000 1 . 000 1 . 000 028400 Full comment : 0284001 0103166001 lCO Ginger-babyfood Full comment : 0284001 0 . 050000 1 . 000 1 . 000 028400 0103167000 lCO Ginger , dried 0 . 050000 Full comment : 0284001 0103296000 lC Potato , chips 0 . 050000 Full comment : 0284001 0103297000 lC Potato , dry (granules/ flakes) 0 . 050000 Full comment : 0284001 0103297001 lC Potato , dry (granules/ flakes)-b 0 . 050000 Full comment : 0284001 0103298000 lC Potato , flour 0 . 050000 Full comment : 0284001 0103298001 lC Potato , flour

- babyfood 0 . 050000 Full comment : 0284001 0103299000 lC Potato , tuber , w/peel 0 . 050000 Full comment : 0284001 0103299001 lC Potato , tuber , w/peel-babyfood 0 . 050000 Full comment : 0284001 0103300000 lC Potato , tuber , w/o peel 0 . 050000 Full comment : 0284001 0103300001 lC Potato , tuber , w/o peel-babyfood 0 . 050000 Full comment : 0284001 0103366000 lCD Sweet potato 0 . 050000 Full comment : 0284001 0103366001 lCD Sweet potato - babyfood 0 . 050000 Full comment : 0284001 0103371000 lCD Tanier , corm 0 . 050000 Full comment : 0284001 0103387000 lCD Turmeric 0 . 050000 Full comment : 0284001 0103406000 lCO Yam , true 0 . 050000 Full comment : 0284001 0103407000 lCD Yam bean 0 . 050000 Full comment : 0284001 0301165000 3A Garlic , bulb 2 . 000000 0301165001 3A Garlic , bulb-babyfood 2 . 000000 0301237000 3A Onion , bulb 2 . 000000 Full comment : 0284001 0301237001 3A Onion , bulb

- babyfood 2 . 000000 Full comment : 0284001 0301238000 3A Onion , bulb , dried 2 . 000000 Full comment : 0284001 0301238001 3A Onion , bulb , dried

- babyfood 2 . 000000 

### Page 15 of22 1 . 000 1 . 000 028400 1 . 000 1 . 000 028400 6 . 500 1 . 000 028400 6 . 500 1 . 000 028400 6 . 500 1 . 000 028400 6 . 500 1 . 000 028400 1 . 000 1 . 000 028400 1 . 000 1 . 000 028400 1 . 000 1 . 000 028400 1 . 000 1 . 000 028400 1 . 000 1 . 000 028400 1 . 000 1 . 000 028400 1 . 000 1 . 000 028400 1 . 000 1 . 000 028400 1 . 000 1 . 000 028400 1 . 000 1 . 000 028400 1. 000 1. 000 1.000 1. 000 1 . 000 1 . 000 028400 1 . 000 1 . 000 028400 9 . 000 1 . 000 028400 9 . 000 1 . 000 028400

### P yrimethanil Dietary Exposure and Ri sk Assessment DP # 424861 Full comment : 02B4001 030133BOOO 3A Shallot , bulb 2 . 000000 1 . 000 1 . 000 0302103000 3B Chive , fresh leaves 3 . 000000 1 . 000 1 . 000 030219BOOO 3B Leek 3 . 000000 1 . 000 1 . 000 0302239000 3B Onion , green 3 . 000000 1 . 000 1 . 000 02B400 Full comment : 02B4001 030233B500 3B Shallot , fresh le aves 3 . 000000 1 . 000 1 . 000 OB01374000 BA Tomatillo 0 . 500000 1 . 000 1 . 000 OB01375000 BA Tomato 0 . 500000 1 . 000 1 . 000 02B400 Full comment : 02B4001 OB01375001 BA Tomato-babyfood 0 . 500000 1 . 000 1 . 000 02B400 Full comment : 02B4001 OB01376000 BA Tomato , paste 0 . 500000 5 . 400 1 . 000 02B400 Full comment : 02B4001 OB01376001 BA Tomato , paste - babyfood 0 . 500000 5 . 400 1 . 000 02B400 Full comment : 02B400 1 OB01377000 BA Tomato , puree 0 . 500000 3 . 300 1 . 000 02B400 Full comment : 02B4001 OB01377001 BA Tomato , puree-babyfood 0 . 500000 3 . 300 1 . 000 02B400 F

ull comme n t : 02B4001 OB0137BOOO BA Tomato , dried 0 . 500000 14 . 300 1 . 000 02B 4 00 F

ull comment : 02B4001 OB0137B001 BA Tomato , dried-babyfood 0 . 500000 14 . 300 1.000 02B400 Full comment : 02B4001 OB01379000 BA Tomato , juice 0 . 500000 1 . 500 1 . 000 028400 Full comment : 0284001 OB013BOOOO BA Tomato , Tree 0 . 500000 1 . 000 1 . 000 0902135000 98 Cucumber 1 . 500000 1 . 000 1 . 000 1001106000 lOA Citron 10 . 000000 1 . 000 1 . 000 02B400 F

ull comment : 02B4001 1001107000 lOA Citrus hybrids 10 . 000000 1 . 000 1.000 02B400 F

ull comment : 02B 4001 1001108000 lOA Citrus , oil 150 . 000000 1 . 000 1 . 000 02B400 Full comment : 02B 4001 1001240000 lOA Orange 10 . 000000 1 . 000 1 . 000 02B400 Full comment : 02B4001 1001241000 lOA Orange , juice 10 . 000000 0 . 007 1 . 000 02B400 Full comment : 02B4001 1001241001 lOA Orange , juice

- babyfood 10 . 000000 0 . 007 1 . 000 028400 Full comment : 0284001 1001242000 lOA Orange , peel 10 . 000000 1 . 000 1 . 000 02B400 Full comment : 0284001 1001369000 lOA Tangerine 10 . 000000 1 . 000 1 . 000 02B400 F

ul l comment : 02B4001 1001370000 lOA Tangeri ne , j u ice 10 . 000000 2 . 300 1 . 000 028400 Fu ll comment : 02B 4001 1002197000 lOB Kumquat 10 . 000000 1 . 000 1 . 000 02B 400 Full comment : 02B4001 1002199000 lOB Lemon 10 . 000000 1 . 000 1 . 000 BE7353 Full comment : 8E7353 Proposed Tolerance 2009 1002200000 108 Lemon , juice 10 . 000000 2 . 000 1 . 000 BE7353 Full comment : 8E7353 Proposed Tolerance 2009 1002200001 lOB Lemon , juice-babyfood 10 . 000000 2 . 000 1 . 000 BE7353 Full comment : 8E7353 Proposed Tolerance 2009 1002201000 108 Lemon , peel 10 . 000000 1 . 000 1 . 000 8E7353 F

ul l comment : 8E7353 Proposed Tolerance 2009 1002206000 1 08 Lime 10 . 000000 1 . 000 1 . 000 028400 Full comment : 02B4001 1002207000 lOB Lime , juice 10 . 000000 2 . 000 1 . 000 028400 Full comment : 02B4001 1002207001 lOB Lime , juice-baby fo od 10 . 000000 2 . 000 1 . 000 02B400 Full comment : 0284001 10031BOOOO lOC Grapefruit 10 . 000000 1 . 000 1 . 000 028400 Full comment : 0284001 1003181000 lOC Grapefruit , juice 10 . 000000 2 . 100 1 . 000 028400 Full comment : 0284001 1003307000 lOC Pummelo 10 . 000000 1 . 000 1 . 000 028400 Full comment : 0284001 

### 1100007000 11 Apple , fruit wit h peel 

### 15 . 000000 1 . 000 1 . 000 DP# 

### 34 F ul l comment : OPff 347248 llOOOOBOOO 11 Apple , peeled fruit 15 . 000000 1 . 000 1 . 000 DP # 3 4 

### Page 16of22

### Pyrimethanil Di etary Exposure and R isk Assessment 

### DP # 424861 Full comment : DP# 347248 

### 1100008001 11 

### Apple, peeled fruit · babyfood 

### 15 . 000000 1 . 000 1.000 D Ptt 

### 34 Full comment : DP# 347248 1100009000 11 Apple , dried 15 . 000000 8 . 000 1 . 000 DP# 34 Full comment : DP # 347248 1100009001 11 Apple , dried-babyfood 15 . 000000 8 . 000 1 . 000 DP# 34 Full comment : DP# 347248 1100010000 11 Apple , juice 15 . 000000 0 . 350 1 . 000 DP# 34 Full comment : DP# 347248 1100010001 11 Apple , juice

- babyfood 15 . 000000 0 . 350 1 . 000 DP# 34 Full comment : DP!I 347248 1100011000 11 Apple , sauce 15 . 000000 1 . 000 1 . 000 DPll 34 Full comment : DP!I 347248 1100011001 11 Apple , sauce-babyfood 15 . 000000 1 . 000 1 . 000 DP# 34 Full comme nt : DP# 347248 1100129000 11 Crabapple 15 . 000000 1 . 000 1 . 000 DP# 34 E'ull comment : DP# 347248 1100210000 11 Loquat 15 . 000000 1 . 000 1 . 000 DP# 34 Full comment : DP# 347248 1100266000 11 Pear 15 . 000000 1 . 000 1 . 000 DP# 34 Full comment : DP# 347248 1100266001 11 Pear-babyfood 1 5 . 000000 1 . 000 1 . 000 DP# 34 Full comme n t : DP# 347248 1100267000 11 Pear , dried 15 . 000000 6 . 250 1 . 000 DP# 34 Full comment : DP# 347248 1100268000 11 Pear , juic e 15 . 000000 1 . 000 1 . 000 DP# 34 Full comment : DP# 347248 1100268001 11 Pear , juice

- babyfood 15 . 000000 1 . 000 1 . 000 DP# 34 Full comment : DP # 347248 1100310000 11 Quince 15 . 000000 1 . 000 1 . 000 DP# 34 Full comment : DP# 347248 1201090000 12A Cherr y 10 . 000000 1 . 000 1 . 000 8E7353 Full comment : 8E7353 Proposed Tolerance 2009 1201090001 12A Cherry

- babyfood 10 . 000000 1 . 000 1 . 000 8E7353 Full comment : 8E7353 Proposed Tolerance 2009 1201091000 12A Cherry , juice 10 . 000000 1 . 500 1 . 000 8E7353 Full comment : 8E7353 Proposed Tolerance 2009 1201091001 12A Cherry , jui ce - babyfood 10 . 000000 1 . 500 1 . 000 8E7353 Full comment : 8E7353 Proposed Tolerance 2009 1202012000 128 Apricot 10 . 000000 1 . 000 1 . 000 8E 7353 Full comment : 8E7353 Proposed Tolerance 2009 1202012001 128 Apricot-babyfood 10 . 000000 1 . 000 1 . 000 8E7353 Full comment : 8E7353 Propos ed Tolerance 2009 1202013000 128 Apricot , dried 10 . 000000 6 . 000 1 . 000 8E7353 Full comment : 8E7353 Proposed Tolerance 2009 1202014000 128 Apr ico t , j uice 1 0 . 000000 1 . 000 1 . 000 8E7353 Fu ll comment : 8 E 7353 P r oposed Tolerance 2009 1202014001 128 Apricot , jui ce-babyfood 10 . 000000 1 . 000 1 . 000 8E7353 Full comme nt : 8E7353 Proposed To lerance 2009 1202230000 128 N ectarine 10 . 000000 1 . 000 1 . 000 8E7353 Full comme nt : 8E7353 Pr oposed Tolerance 2009 1202260000 128 Peach 10 . 000000 1 . 000 1 . 000 8E7353 Full comment : 8£7353 Prop osed Tolerance 2009 1202260001 128 Peach-baby food 10 . 000000 1 . 000 1 . 000 8E7353 Full comment : 8E7353 Proposed Tolerance 2009 1202261000 128 Peach , dried 10 . 000000 7 . 000 1 . 000 8E7353 Full comment : 8E7353 Proposed Tolerance 2009 1202261001 128 Peach , dried-babyfood 10 . 000000 7 . 000 1 . 000 8E7353 Full comment : 8E7353 Proposed Tolerance 2009 1202262000 128 Peach , Juice 10 . 000000 1 . 000 1 . 000 8E7353 Full comment : 8E7353 Proposed Tolerance 2009 1202262001 128 Peach , juice -babyfood 10 . 000000 1 . 000 1 . 000 8E7353 Full comment : 8E7353 Proposed Tole rance 2009 1203285000 12C Plum 10 . 000000 1 . 000 1 . 000 8E7353 Full comme n t : 8E7353 Proposed Tolerance 2009 1203285001 12C Plum-baby food 10 . 000000 1 . 000 1 . 000 8E7353 Full comment : 8E7353 Proposed Tolerance 2009 1203286000 12C Plum , prune , fresh 1 0 . 000000 1 . 000 1 . 000 8E7353 Full comment : 8E7353 Proposed Toleranc e 2009 1203286001 12C Plum , prune , fresh-babyfood 10 . 000000 1 . 000 1 . 000 8E7353 Full comment : 8E7353 Proposed Tol erance 2009 

### Page 17 of22

### P yrimethanil Dietary Exposure and Ri sk Assessment DP# 424861 1203287000 12C Plum , prune , dried 10 . 000000 5 . 000 1 . 000 8E7353 Full comment : 8E7353 Proposed Tolerance 2009 1203287001 12C Plum , prune , dried

- babyfood 10 . 000000 5 . 000 1 . 000 8E7353 Full comment : 8E7353 Proposed Tolerance 2009 1203288000 12C Plum , prune , juice 10 . 000000 1 . 400 1 . 000 8E7353 Full comment : 8E7353 Proposed Tolerance 2009 1203288001 12C Plum , prune , juice-babyfood 10 . 000000 1 . 400 1 . 000 8E7353 Full comment : 8E7353 Proposed Tolerance 2009 1301055000 13A Blackberry 15 . 000000 1 . 000 1 . 000 1301056000 13A Blackberry , juice 15 . 000000 1 . 000 1 . 000 1301056001 13A Blackberry , juice-babyfood 15 . 000000 1 . 000 1 . 000 1301058000 13A Boysenberry 15 . 000000 1 . 000 1 . 000 1301208000 13A Loganberry 15 . 000000 1 . 000 1 . 000 1301320000 13A Raspberry 15 . 000000 1 . 000 1 . 000 1301320001 13A Raspberry-babyfood 15 . 000000 1 . 000 1.000 1301321000 13A Raspberry , juice 15 . 000000 1 . 000 1 . 000 1301321001 13A Raspberry , juice

- babyfood 15 . 000000 1 . 000 1 . 000 1302057000 13B Blueberry 8 . 000000 1 .0 00 1 . 000 1302057001 13B Blueberry-babyf ood 8 . 000000 1 . 000 1 . 000 1302136000 13B Currant 8 . 000000 1 . 000 1 . 000 1302137000 13B Currant , dried 8 . 000000 1 . 000 1 . 000 1302149000 138 Elderberry 8 . 000000 1 . 000 1 . 000 1302174000 138 Gooseberry 8 . 000000 1 . 000 1 . 000 1302191000 13B Huckleberry 8 . 000000 1 . 000 1 . 000 1304175000 130 Grape 5 . 000000 1 . 000 1 . 000 028400 Full comment : 0284001 1304176000 130 Grape , juice 5 . 000000 1 . 200 1 . 000 028400 Full comment : 0284001 1304176001 130 Grape , juice-babyfood 5 . 000000 1 . 200 1 . 000 028400 Full comment : 0284001 1304 179000 130 Grape , wine and sherry 5 . 000000 1 . 000 1 . 000 028400 Full comment : 0284001 1307130000 13G Cranberry 3 . 000000 1 . 000 1 . 000 1307130001 13G Cranberry-babyfood 3 . 000000 1 . 000 1 . 000 1307131000 13G Cranberry , dried 3 . 000000 1 . 000 1 . 000 1307132000 13G Cranberry , juice 3 . 000000 1.100 1 . 000 1307132001 13G Cranberry , juice -babyfood 3 . 000000 1 . 100 1 . 000 1307359000 13G Strawberry 3 . 000000 1 . 000 1 . 000 028400 Full comment : 0284001 1307359001 13G Strawberry-babyfood 3 . 000000 1 . 000 1 . 000 028400 Full comment : 0284001 1307360000 13G Strawberry , juice 3 . 000000 1 . 000 1 . 000 028400 Full comment : 0284001 1307360001 13G Strawberry , juice-babyfood 3 . 000000 1 . 000 1 . 000 028400 Full comment : 0284001 1400003000 1 4 Almond 0 . 200000 1 . 000 1 . 000 028400 Full comment : 0284001 1400003001 14 Almond-babyfood 0 . 200000 1 . 000 1 . 000 028400 Full comment : 0284001 1400004000 14 Almond , oil 0 . 200000 1 . 000 1 . 000 028400 Full comment : 0284001 1400004001 14 Almond , oil-babyfood 0 . 200000 1 . 000 1 . 000 028400 Full comment : 0284001 1400282000 14 Pistachio 0 . 200000 1 . 000 1 . 000 3100044000 31 Beef , meat 0 . 010000 1 . 000 1 . 000 028400 Full comment : 0284001 3100044001 31 Beef , meat-babyfood 0 . 010000 1 . 000 1 . 000 028400 Full comment : 028400 1 3100045000 31 Beef , meat , dried 0 . 010000 1 . 920 1 . 000 028400 Full comment : 028400 1 3100046000 31 Beef , meat byproducts 0 . 010000 1 . 000 1 . 000 028400 Full comment : 0284001 3100046001 31 Beef, meat byproducts-babyfood 0 . 010000 1 . 000 1 . 000 028400 Full comment : 0284001 3100047000 31 Beef, fat 0 . 010000 1 . 000 1 . 000 028400 Full comment : 0284001 3100047001 31 Beef , fat-babyfood 0 . 010000 1 . 000 1 . 000 028400 Full comment : 0284001 3100048000 31 Beef, kidney 2 . 500000 1 . 000 1 . 000 DP# 34 Full comment : OPH 347248 3100049000 31 Beef , liver 0 . 010000 1 . 000 1 . 000 028400 

### Page 18 of22

### P yrimethani l Dietary Exposure and Risk Assessment DP # 424861 Full comment : D284001 3100049001 31 Beef , liver-babyfood 0 . 010000 1 . 000 1 . 000 028400 Full comment : 0284001 3200169000 32 Goat , meat 0 . 010000 1 . 000 1 . 000 D28400 Full comment : D284001 3200170000 32 Goat , meat byproducts 0 . 010000 1 . 000 1 . 000 D28400 Full comment : D284001 3200171000 32 Goat , fat 0 . 010000 1 . 000 1 . 000 D28400 Full comment : D284001 3200172000 32 Goat, kidney 2 . 500000 1 . 000 1 . 000 DP!t 34 Full comment : DPH 347248 3200173000 32 Goat , liver 0 . 010000 1 . 000 1 . 000 028400 Full comment : D284001 3300189000 33 Horse , meat 0 . 010000 1 . 000 1 . 000 D28400 Full comment : D284001 3500339000 35 Sheep , meat 0 . 010000 1 . 000 1 . 000 D28400 Full comment : D284001 3500339001 35 Sheep , meat - babyfood 0 . 010000 1 . 000 1 . 000 028400 Full comment : 028 4001 3500340000 35 Sheep , meat byproducts 0 . 010000 1 . 000 1 . 000 D28 400 Full comment : 0284001 3500341000 35 Sheep , fat 0 . 010000 1.000 1 . 000 028 400 Full comment : 0284001 3500341001 35 Sheep , fat

- babyfood 0 . 010000 1 . 000 1 . 000 D28400 Full comment : D284001 3500342000 35 Sheep , kidney 2 . 500000 1 . 000 1 . 000 DP# 34 Full comment : DP ti 347248 3500343000 35 Sheep , liver 0 . 010000 1 . 000 1 . 000 D28400 Full comment : D284001 3600222000 36 Milk , fat 0 . 050000 1 . 000 1 . 000 DP# 34 Full comment : DP# 347248 3600222001 36 Milk , fat-baby food/infant formu 0 . 050000 1 . 000 1 . 000 DPH 34 Full comment : DP# 347248 3600223000 36 Milk , nonfat solids 0 . 050000 1.000 1 . 000 DPH 34 Full comment : DPli 347248 3600223001 36 Milk , nonfat solids-baby food/in 0 . 050000 1 . 000 1 . 000 DP# 34 Full comment : DP# 347248 3600224000 36 Milk , water 0 . 050000 1 . 000 1 . 000 DP# 34 Full comment : DP# 347248 3600224001 36 Milk , water- babyfood/infant form 0 . 050000 1 . 000 1 . 000 DP# 34 Full comment : DP# 347248 3600225001 36 Milk , sugar (lactose) -baby food/ 0 . 050000 1 . 000 1 . 000 DP# 34 Full comment : DP# 347248 8601000000 86A W ater , direct , all sources 0 . 027900 1 . 000 1 . 000 8602000000 86B Water , indirect , all sources 0 . 027900 1 . 000 1 . 000 9500023000 0 Banana 0 . 100000 1 . 000 1.000 9500023001 0 Banana-babyfood 0 . 100000 1.000 1 . 000 9500024000 0 Banana , dried 0 . 100000 3 . 900 1.000 9500024001 0 Banana , dried

- babyfood 0 . 100000 3 . 900 1.000 9500177000 0 Grape , leaves 5 . 000000 1 . 000 1 . 000 D28400 Full comment : D284001 9500178000 0 Grape , raisin 8 . 000000 1 . 000 1 . 000 D28400 Full comment : D284001 9500283000 0 Plantain 0 . 100000 1 . 000 1 . 000 9500284000 0 Plantain , dried 0 . 100000 3 . 900 1 . 000 9500289000 0 Pomegranate 5 . 000000 1 . 000 1 . 000



### Page 19 of22

### Pyri methanil Dietary Exposure and Risk Assessment DP # 42486 1 

## Attachment 4 : DEEM-FCID Chronic Exposure and Risk Es tim ates - Foo d plu s Water us EPA Ver . 3 . 16 , 03

- 08

- d DEEM

- FCID Chronic ana lysi s for PYRIMETHANIL NHANES 2003-2008 2-day Residue file name : C : \Users\gkramer\Documents\Gk\#Pyrimethanil\Pyrimethani l chronic . R08 Adjustment factor lt2 used . Analysis Date 05

- 28

- 2015/11 : 03 : 22 Residue file dated : 05-28-2015/09 : 57 : 00 Reference dose (RfD , Chronic) 

### = . 17 mg/kg bw/day COMMENT 1 : FQPA SF lX for all endpoints ; cPAD for all popu la tions is 0 . 17 mg/kg/day

Population

Subgroup Total 

### us Population Hispanic Non-Hisp-White Non-Hisp-Black Non-Hisp-Other Nursing Infants Non-Nursing Infa n ts Female 13+ PREG Children 1

- 6 Children 7-12 Male 13-19 Female 1 3-19/NP Male 20+ Female 20+/NP Seniors 55 + All Infants Female 13-50 Children 1-2 Children 3

- 5 Children 6-12 Youth 13-19 Adults 20-49 Adults 50-99 Female 13-49 Total exposure by popu latio n subgroup Tota l Exposure mg/kg body wt/day 0 . 024977 0 . 031428 0 . 023423 0 . 024807 0 . 029368 0 . 059140 0 . 104490 0 . 021041 0 . 098700 0 . 033432 0 . 014965 0 . 017081 0 . 014481 0 . 016288 0 . 017384 0 . 090488 0 . 0 1 5559 0 . 136305 0 . 082594 0 . 038145 0 . 016025 0 . 014440 0 . 017030 0 . 015479



### Page 20 of22 Percent of Rfd 14 . 7% 18 . 5% 13 . 8 % 14 . 6% 17 . 3 % 34 . 8% 61.5 % 12 . 4 % 58 . 1% 19 . 7%

8 . 8 % 10 . 0 %

8 . 5 % 9 . 6% 10 . 2% 53 . 2 %

9 . 2% 80 . 2% 48 . 6% 22 . 4 %

9 . 4 % 8 . 5 % 10 . 0%

9 . 1%

### P yrim ethanil Dietary Exposure and Ri sk A ssessm ent DP # 424861 

## Attachment 5: DEEM-FCID Acute Exposure and Ri sk Estimates - Food Only US EPA DEEM-FCID ACUTE Analysis for PYRIMETHANIL Residue file : Pyrimethanilacute

_ Food only . ROS Analysis Date : 05

- 28

- 2015/11 : 09 : 13 Residue file Ver . 3 . 18 , 03

- 08

- d NHANES 2003

- 2008 2 -Day Adjustment factor #2 used . dated : 05-28

- 2015/09 : 56 : 27 NOEL (Acute ) 

## = 100 . 000000 mg/kg body

- wt/day RAC/FF intake summed over 24 hours Run Comment : " FQPA SF lX for all endpoints ; cPAD for all populations is 0 . 17 m g/kg/day " Summary calculations --per capita : 95th Percentile---- 99th Percentile---- ---99 . 9th Percentile---- Exposure % aRfD M OE Exposure % aRfD MOE Exposure % aRfD MOE



# ---------- ------- -------- 

# ------ --- - --- - --- ----- --- 

# ---------- --- ---- 

# -------- Total 

### us Population : 0 . 100979 10 . 10 990 0 . 238699 23 . 87 41 8 0 . 510901 5 1. 09 195 All Infants : 0 . 366002 36 . 60 273 0 . 55 103 2 55 . 10 181 0 . 717833 71 . 78 139 Children 1-2 : 0 . 392227 39 . 22 254 0 . 621139 62 . 11 160 0 . 978217 97 . 82 102 Children 3-5 : 0 . 251471 25 . 15 397 0 . 365350 36 . 54 273 0 . 552961 55 . 30 180 Children 6-12 : 0 . 134614 13 . 46 742 0 . 231633 23 . 16 431 0 . 376438 37 . 64 265 Youth 13-19 : 0 . 061527 6 . 15 1625 0 . 117545 11. 75 850 0 . 260147 26 . 01 384 Adults 20-49 : 0 . 056690 5 . 67 1763 0 . 099946 9 . 99 1000 0 . 191079 19 . 11 523 Adults 50-99 : 0 . 059286 5 . 93 1686 0 . 097410 9 . 74 1026 0 . 176266 17 . 63 567 Female 13-49 : 0 . 059514 5 . 95 1680 0 . 103518 10 . 35 966 0 . 231358 23 . 14 432



### Page 2 1 

### of 22

### Pyrimethanil Dietary Expo su re and Ri sk Assessment DP # 424861 

## Attachment 6: DEEM-FCID Chronic Exposure and Risk Estimates - Food Only US EPA Ver . 3 . 16 , 03-08-d DEEM-FCID Chronic analysis for PYRIMETHANIL NHANES 2003-2008 2

- day Residue file name : C : \Users\gkramer\Documents\Gk\#Pyrimethanil\Pyri me t hanilchron i c_Food only . ROB Adjustment factor**~2** used . Analys i s Date 05

- 28

- 20 1 5/11 : 04 : 42 Residue file dated : 05-28-2015/09 : 57 : 39 Reference dose (RfD , Chronic) 

### = . 17 mg/kg bw/day COMMENT 1 : FQPA SF lX for all endpoints ; cPAD for a l l populat i ons is 0 . 17 mg/kg/day

Population

Subgroup Total US Population H

ispanic Non-Hisp-White Non

- Hisp

- Black Non

- Hisp

- Other Nurs i ng Infants Non

- Nurs i ng Infants Female 13+ PREG Children 1 -6 Children 7

- 12 Male 1 3

- 19 Female 13

- 1 9/NP Male 20+ Female 20+/NP Seniors 55+ A

ll Infants Female 13-50 Children 1

- 2 Children 3-5 Children 6

- 12 Youth 13

- 19 Adu l ts 20-49 Adu l ts 50-99 Female 13-49 Total exposure by popu l ation subgroup Total Exposure mg/kg body wt/day 0 . 024393 0 . 030871 0 . 022822 0 . 024325 0 . 028695 0 . 058611 0 . 102546 0 . 020491 0 . 097952 0 . 032945 0 . 014564 0 . 016631 0 . 013937 0 . 015675 0 . 0 1 6819 0 . 088982 0 . 014978 0 . 135463 0 . 081884 0 . 037633 0 . 015599 0 . 013857 0 . 0 1 6454 0 . 014899



### Page 22 of22 Percent o f Rfd 14 . 3 % 1 8 . 2 % 1 3 . 4 % 14 . 3 % 16 . 9 % 34 . 5 % 60 . 3 % 12 . 1 % 57 . 6 % 19 . 4 %

8 . 6% 9 . 8 % 8 . 2% 9 . 2% 9 . 9 % 52 . 3 %

8 . 8 % 79 . 7 % 48 . 2 % 22 . 1 %

9 . 2 % 8 . 2 % 9 . 7% 8 . 8 %