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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549





FORM 10-K

(Mark one)



|x | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ------------------------------------------------------------------------------------

For the fiscal year ended December 30, 2007

or



| ̈ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ----------------------------------------------------------------------------------------

For the transition period from
 to

Commission File Number: 0-26137

drugstore.com, inc.

(Exact Name of Registrant as Specified in its Charter)



|                                                               |  |                                                     
|-------------------------------------------------------------- |  | ----------------------------------------------------
|Delaware                                                       |  | 04-3416255                                          
|(State or Other Jurisdiction of Incorporation or Organization) |  | (I.R.S. Employer Identification No.)                
|                                                               | 
|411 108thAvenue NE,
Suite 1400 Bellevue, Washington 98004      |  | (425) 372-3200                                      
|(Address of Principal Executive Offices)                       |  | (Registrants telephone number, including area code)





Securities registered pursuant to
Section 12(b) of the Act:



|                                          |  |                                               
|----------------------------------------- |  | ----------------------------------------------
|Title of Each Class                       |  | Name of Each Market on Which Listed           
|Common Stock, par value $0.0001 per share |  | NASDAQ Stock Market LLC (NASDAQ Global Market)

Securities registered pursuant to Section 12(g) of the Act:

None

Indicate by check mark if the registrant is a
well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes   ̈    No  x

Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the
Act.    Yes   ̈    No  x

Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that registrant
was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.    Yes  x    No   ̈

Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is not contained
herein, and will not be contained, to the best of registrants knowledge, in definitive proxy or information statements incorporated by reference in part III of this Form 10-K or any amendment to this Form 10-K.    x

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer,
or a smaller reporting company. See the definitions of large accelerated filer, accelerated filer, and smaller reporting company in Rule 12b-2 of the Exchange Act. (Check one):



|                           |  |                             
|-------------------------- |  | ----------------------------
|Large Accelerated filer   ̈ |  | Accelerated filer  x        
|Non-accelerated filer   ̈   |  | Smaller reporting company   ̈

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).
Yes   ̈    No  x

The aggregate market value of
common stock held by non-affiliates of the registrant was $260,161,542 as of July 1, 2007, the last business day of the registrants most recently completed second fiscal quarter.

As of March 7, 2008, the number of shares of the registrants common stock outstanding was 96,478,573.

DOCUMENTS INCORPORATED BY REFERENCE

The information required by Part III of this annual report,
to the extent not set forth in this annual report, is incorporated by reference from the registrants definitive proxy statement relating to the registrants annual meeting of stockholders to be held on June 12, 2008, which definitive
proxy statement will be filed with the Securities and Exchange Commission within 120 days after the end of the fiscal year to which this annual report relates.









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DRUGSTORE.COM, INC.

ANNUAL REPORT ON FORM 10-K

For the Fiscal Year Ended December 30, 2007

Table of Contents



|           |  |                                                                                                               |  |     
|---------- |  | ------------------------------------------------------------------------------------------------------------- |  | ----
|           |  |                                                                                                               |  | Page
|PART I    
|           |  |                                                                                                              
|ITEM 1.    |  | BUSINESS                                                                                                      |  | 3   
|           |  |                                                                                                              
|ITEM 1A.   |  | RISK FACTORS                                                                                                  |  | 11  
|           |  |                                                                                                              
|ITEM 1B.   |  | UNRESOLVED STAFF COMMENTS                                                                                     |  | 26  
|           |  |                                                                                                              
|ITEM 2.    |  | PROPERTIES                                                                                                    |  | 26  
|           |  |                                                                                                              
|ITEM 3.    |  | LEGAL PROCEEDINGS                                                                                             |  | 26  
|           |  |                                                                                                              
|ITEM 4.    |  | SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS                                                           |  | 26  
|          
|PART II   
|           |  |                                                                                                              
|ITEM 5.    |  | MARKET FOR REGISTRANTS COMMON EQUITY, RELATED STOCKHOLDER MATTERS, AND ISSUER PURCHASES OF EQUITY SECURITIES |  | 27  
|           |  |                                                                                                              
|ITEM 6.    |  | SELECTED FINANCIAL DATA                                                                                       |  | 29  
|           |  |                                                                                                              
|ITEM 7.    |  | MANAGEMENTS DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS                         |  | 30  
|           |  |                                                                                                              
|ITEM 7A.   |  | QUANTITATIVE AND QUALITATIVE DISCLOSURE ABOUT MARKET RISK                                                     |  | 47  
|           |  |                                                                                                              
|ITEM 8.    |  | FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA                                                                   |  | 47  
|           |  |                                                                                                              
|ITEM 9.    |  | CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL DISCLOSURE                          |  | 47  
|           |  |                                                                                                              
|ITEM 9A.   |  | CONTROLS AND PROCEDURES                                                                                       |  | 47  
|           |  |                                                                                                              
|ITEM 9B.   |  | OTHER INFORMATION                                                                                             |  | 50  
|          
|PART III  
|           |  |                                                                                                              
|ITEM 10.   |  | DIRECTORS, EXECUTIVE OFFICERS, AND CORPORATE GOVERNANCE                                                       |  | 50  
|           |  |                                                                                                              
|ITEM 11.   |  | EXECUTIVE COMPENSATION                                                                                        |  | 50  
|           |  |                                                                                                              
|ITEM 12.   |  | SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDER MATTERS                |  | 50  
|           |  |                                                                                                              
|ITEM 13.   |  | CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCE                                     |  | 50  
|           |  |                                                                                                              
|ITEM 14.   |  | PRINCIPAL ACCOUNTING FEES AND SERVICES                                                                        |  | 50  
|          
|PART IV   
|           |  |                                                                                                              
|ITEM 15.   |  | EXHIBITS, FINANCIAL STATEMENT SCHEDULES                                                                       |  | 51  
|           | 
|SIGNATURES |  | 89                                                                                                           



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|ITEM 1. | BUSINESS
|------- | --------

Special Note Regarding Forward-Looking Statements

This annual report on Form 10-K and the documents incorporated into this annual report by reference contain forward-looking statements
within the meaning of the Private Securities Litigation Reform Act of 1995 based on our expectations, estimates and projections as of the date of this filing. Actual results may differ materially from those expressed in forward-looking statements.
All statements made in this annual report other than statements of historical fact, including statements regarding our future financial and operational performance, sources of liquidity and future liquidity needs, are forward-looking. Words such as
expects, believes, targets, may, will, outlook, continue, remain, could, would, should, and similar expressions or
any variation of such expressions, are intended to identify forward-looking statements. Forward-looking statements are based on current expectations, and are not guarantees of future performance and involve assumptions, risks, and uncertainties.
Actual performance may differ materially from those contained or implied in such forward-looking statements. Risks and uncertainties that could lead to such differences could include, among other things: effects of changes in the economy, changes in
consumer spending, fluctuations in the stock market, changes affecting the Internet, online retailing and advertising, difficulties establishing our brand and building a critical mass of customers, the unpredictability of future revenues and
expenses and potential fluctuations in revenues and operating results, risks related to business combinations and strategic alliances, tax liabilities relating to the collection of sales tax, consumer trends, the level of competition, seasonality,
the timing and success of expansion efforts, risks related to systems interruptions, possible governmental regulation, and the ability to manage a growing business. These and other risks and uncertainties that could cause our actual results to
differ significantly from managements expectations are described in the following discussion and in the section entitled Risk Factors in Part I, Item 1A of this annual report. You should not rely on a forward-looking statement
as representing our views as of any date other than the date on which we made the statement. We expressly disclaim any intent or obligation to update any forward-looking statement after the date on which we make it.

Overview

drugstore.com, inc. is a leading online provider of health, beauty, vision, and pharmacy products. We offer health, beauty, sexual well-being, household, and other non-prescription products and prescription
medications through our website at www.drugstore.com.We also offer prestige beauty products through our website located at www.beauty.com (which is also accessible through the drugstore.comTMwebsite); contact lenses through our wholly owned subsidiary Vision Direct, Inc., through websites located at www.visiondirect.com, www.lensmart.com, and
www.lensquest.com (which are also accessible through the drugstore.com website); and customized nutritional supplement programs through our wholly owned subsidiary, Custom Nutrition Services, Inc., or CNS. Our products are also available
toll-free by telephone at 1-800-DRUGSTORE and 1-800-VISIONDIRECT. Under the terms of an agreement with Rite Aid Corporation, customers are also able to order refill prescriptions for pickup at any Rite Aid store. As of December 30, 2007, our
lifetime customer base was nearly 10.0 million customers.

We operate our business in four segments: over-the-counter, or OTC;
mail-order pharmacy; local pick-up pharmacy; and vision. Additional information regarding our business segments can be found in the section entitled Managements Discussion and Analysis of Financial Condition and Results of
Operations in Part II, Item 7 of this annual report and in Note 13 of our consolidated financial statements included in Part IV, Item 15 of this annual report. In 2007, 2006, and 2005, approximately 99% of our net sales were
made, and over 99% of our assets were located, in the United States.

drugstore.com, inc. was incorporated in April 1998 in the state of
Delaware. We launched our web store at www.drugstore.comin February 1999 and completed our initial public offering in July 1999. Our common stock is listed on the NASDAQ Global Market under the symbol DSCM. Our principal
corporate offices are located in Bellevue, Washington. As used in this annual report, drugstore.com, we, our, and similar terms refer to drugstore.com, inc. and its subsidiaries, unless the context indicates
otherwise.



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Business Strategy

Our business strategy is to offer our customers a wide selection of products at competitive prices and a superior online shopping experience.

Convenience.    Our online stores are available to consumers 24 hours a day, seven days a week through the
Internet. All of our products are also available for purchase by phone. We offer additional convenience to our customers through easy-to-use websites, robust search technology, and a variety of features such as: Your List, a
personal shopping list of the customers previous purchases that allows for quick and easy re-ordering, even without browsing the site; Auto Delivery, which enables customers to set up automatic shipments of frequently
ordered products; the ability to schedule e-mail reminders about previously purchased products that are scheduled to run out or are on sale; and an automated flexible spending account, or FSA, manager that keeps track of FSA-eligible purchases and
provides customers with downloadable receipts to submit to their FSA administrator.

Selection.We
are able to offer a significantly broader assortment of products, with greater depth in each product category, because we do not have the shelf display space limitations of brick-and-mortar drugstores. With a single check-out, our customers are able
to buy health, beauty and personal care products, prestige beauty brands, salon hair care, natural products, and other specialty items. In addition, we offer contact lenses and customized nutritional supplement programs through our subsidiary
websites.

Information.    We provide a broad array of interactive tools and information on our websites to help
consumers make informed purchasing decisions. Our information services include detailed product information pages; personalized product recommendations; customer reviews and other editorial content; the eMedAlertprogram, which alerts
customers to safety issues such as FDA and product manufacturer recalls; and extensive health- and pharmacy-related information, including a drug information database, a drug price index, information on generic drug alternatives, a drug interaction
checker; and Ask Your Pharmacist, which is a database of our pharmacists responses to over 800 frequently-asked questions. Our customer care representatives and in-house pharmacists are available by phone or e-mail to provide personal
guidance and answer customers questions.

Privacy.    When shopping at a brick-and-mortar drugstore, many
consumers may feel embarrassed or uncomfortable about buying items or asking questions that may reveal personally sensitive aspects of their health or lifestyle to pharmacists, store personnel, or other shoppers. Our customers avoid these problems
by shopping from the privacy of their home or office.

Value.    Our goal is to offer shoppers a
broad assortment of health, beauty, vision, and pharmacy products with competitive pricing. We strive to improve our operating efficiencies and to leverage our fixed costs so that we can pass along the savings to our customers in the form of lower
prices and exclusive deals. We also seek to inform customers of additional cost-saving opportunities when they become available. For example, in our pharmacy, we inform our customers of quantity price breaks for buying 90-day supplies of medication
rather than 30-day supplies.

Business Segments

In 2007, our OTC segment accounted for 53% of our net sales, our vision segment accounted for 12%, our local pick-up pharmacy segment accounted for 24%, and our mail-order pharmacy segment accounted for 11%. See Note
13 of our consolidated financial statements included in Part IV, Item 15 of this annual report.



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OTC

We stock approximately 30,000 non-prescription health, beauty, personal care, household, and other products. We also offer approximately 6,000 products through our arrangements with drop-ship vendors. We offer OTC
products in a variety of categories, including:



|                            |  |                                                                                       
|--------------------------- |  | --------------------------------------------------------------------------------------
|        Personal Care      |  |         Diet and Fitness                                                             
|                            | 
|        Beauty and Jewelry |  |         Household and Pets                                                           
|                            | 
|        Hair               |  |         Baby                                                                         
|                            | 
|        Skin Care          |  |         Food and Gourmet                                                             
|                            | 
|        Mens              |  |         FSA                                                                          
|                            | 
|        Health             |  |         Sexual Well-Being                                                            
|                            | 
|        Vitamins           |  |         Natural                                                                      
|                            | 
|        Home Medical       |  |         Toys and Games                                                               
|                            | 
|        Gifts and Flowers  |  |         Beauty.com (prestige beauty products, also accessible through
www.beauty.com)
|        GNC                | 

In addition, through our subsidiary CNS, we also provide personalized nutrition services to
consumers in the form of an online assessment of an individuals specific nutritional supplement needs, and deliver the personalized vitamins, minerals, herbs, and supplements in pharmaceutical-grade, daily dose packages. We are the exclusive
online distributor of nutritional supplement programs for Dr. Barry Sears at www.ZoneDiet.com and The Pritikin Longevity Center & Spa at www.Pritikin.com. In addition, we act as the exclusive fulfillment provider for
customized nutritional supplements sold through www.DrWeilVitaminAdvisor.com, www.DrWeil.com, and other Dr. Weil-related websites.

Mail-Order Pharmacy and Local Pick-Up Pharmacy

Our pharmacy product category is divided into
two business segments: mail-order pharmacy and local pick-up pharmacy. Our mail-order pharmacy segment covers the prescription drugs and supplies delivered to customers through our mail-order facility, and our local pick-up pharmacy segment covers
the prescriptions picked up by customers at Rite Aid stores. Customers may order new prescriptions on the drugstore.com website for mail-order delivery. Customers may have refill prescriptions, that have previously been filled through our mail-order
facility or at a Rite Aid store, delivered by mail or the customer may pick them up at any Rite Aid store.

We are a full-service pharmacy
stocking over 5,000 prescription drugs. We employ licensed pharmacists and are licensed to ship prescriptions to all 50 states in the United States. We have received Verified Internet Pharmacy Practices Sites, or VIPPS, certification from the
National Association of Boards of Pharmacy, or NABP. The voluntary VIPPS program sets standards for Internet pharmacies and certifies those online pharmacies that are licensed and in compliance with state pharmacy laws and the NABPs stringent
pharmacy practice standards.

We serve both cash-paying pharmacy customers and customers with insurance coverage. In addition, we act as an
outsourced mail-order pharmacy service provider for pharmacy benefit managers, or PBMs.

Vision

Through our subsidiary Vision Direct, we offer a broad assortment of contact lenses, in addition to reading glasses, contact lens cases, and other contact
lens supplies. We believe that we offer these products at a substantial price savings over eye care practitioners, national optical chains, and many online competitors.



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Our contact lens business is subject to the U.S. Fairness to Contact Lens Consumers Act, or FTCLCA, and
the related regulations of the Federal Trade Commission, or FTC, which establish a national uniform standard for eye care practitioners and direct marketers with respect to the sale of contact lenses, including verification of contact lens
prescriptions. In accordance with these guidelines, we ask the patients eye care professional to verify the prescription before we ship an order and allow eight business hours for the eye care professional to reply to our verification request.
If the eye care professional approves the prescription, or does not respond to our verification request within eight business hours, we ship the order to the customer as expressly permitted by the FTCLCA.

Marketing and Promotions

Our marketing and promotion
strategy is designed to build brand recognition, increase customer traffic to our store, add new customers, build strong customer loyalty, maximize repeat purchases, and develop incremental revenue opportunities. Our online advertising campaigns are
focused on search engines, frequently visited Internet portals, health- and beauty-related websites, and direct-to-consumer e-mail marketing programs. We further extend our online market presence through our affiliate program, through which we
permit certain websites to make our products and services available to their audiences through links to our websites.

We also employ a variety of marketing programs and promotions, such as discounted and free
shipping promotions, dollar off and percentage discounts, free gifts with purchase, and the drugstore.com dollarsTMprogram, a loyalty program in
which customers automatically earn a five percent rebate to be used for future non-prescription purchases.

Fulfillment and Customer Care

Order Fulfillment

We process most OTC orders and all mail-order pharmacy orders from our primary distribution center in Swedesboro, New Jersey, and all vision orders from our distribution center in Ferndale, Washington. When a customer orders a refill
prescription to be picked up at a local Rite Aid store, we use Rite Aid as a fulfillment partner. We also process drop-ship orders for certain OTC products and arrange for our drop-ship vendor partners to ship these products directly from the
vendors warehouse. Due to the relatively short lead time required to fill orders for our products, usually 24 to 48 hours, order backlog is not material to our business.

We ship OTC and pharmacy products to U.S., U.S. Territory, and APO/FPO military addresses. In addition, through an agreement with Access USA, Inc., we
offer international shipment of select OTC health, beauty, and wellness products to over 160 countries. Vision Direct ships contact lenses and other vision products worldwide, primarily to the United States and Canada.

Customer Care

Our customer
care representatives operate from our call center in Halifax, Nova Scotia, Canada and from our Bellevue, Washington headquarters. Our customer care specialists are available 24 hours a day, seven days a week via e-mail or telephone to handle
customer inquiries and assist customers in finding desired products. The Help section of our website outlines store policies and provides answers to customers frequently asked questions. In addition, our pharmacists provide advice to customers
about medications and other health-related issues.

Technology

We have implemented a broad array of services and systems for site management, product searching, customer interaction, transaction processing, and order fulfillment functions. These services and systems use a



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combination of our own proprietary technologies and commercially available, licensed technologies. We focus our internal development efforts on creating and
enhancing the specialized, proprietary software that is unique to our business. For example, our core merchandise catalog, customer interaction, order collection, fulfillment, and back-end systems are proprietary to drugstore.com. Our systems are
designed to provide real-time connectivity to the distribution center systems for both pharmacy and OTC products. They include an inventory-tracking system, a real-time order tracking system, an executive information system, and an inventory
replenishment system.

To enhance the online and offline experience for our pharmacy customers, we have integrated some of our information
and pharmacy systems with Rite Aids systems. Rite Aid has granted us a nonexclusive, fully paid license to the Rite Aid systems that are integrated with our systems, subject to third-party rights to such technology. We license database,
operating system, and hardware components from third parties.

In August 1998, we entered into a technology license and advertising
agreement with Amazon.com, Inc. Under this agreement, which expires in August 2008, we have the right to license substantially all of Amazon.coms technology for use in our business and to receive certain technological and advertising support
from Amazon.com, and Amazon.com has the right to license substantially all of our technology for use in its business. Neither party may use the others technology to compete against the other. Currently, neither party has licensed any
technology from the other under this agreement. If we were to be acquired by a competitor of Amazon.com and Amazon.com did not vote its shares of drugstore.com in favor of the transaction, we would lose our rights to use Amazon.coms
technology, if we were using any at that time. This agreement also restricts us from promoting on our website any company, other than drugstore.com, that sells products or services competitive with those that Amazon.com offers or is preparing to
produce or market.

Relationship with Rite Aid

In June 1999, we entered into a strategic relationship with Rite Aid. Through our agreements with Rite Aid, which expire in 2009 unless renewed, we have access to Rite Aid customers through the RiteAid.com website, which is powered by the
drugstore.com website. All pharmacy orders processed through the drugstore.com website or the RiteAid.com website can be either shipped to the customer from our distribution center or, in the case of refills of existing drugstore.com or Rite Aid
prescriptions, picked up by the customer at any Rite Aid store. Rite Aid adjudicates and collects insurance reimbursement payments for prescription medications on our behalf.

In addition to providing for multi-channel delivery options, we and Rite Aid agreed to promote each others services both online and offline. For
example, Rite Aid includes the drugstore.com pharmacy logo on Rite Aid shopping bags, prescription vial caps, receipts, in-store signs and links from the Rite Aid website to the drugstore.com website, as well as in certain of Rite Aids weekly
circular advertisements. As part of our relationship with Rite Aid, we agreed to certain exclusivity provisions that limit our ability to promote, or to affiliate with, any other brick-and-mortar retail drugstore within a five-mile radius of a Rite
Aid store or to operate as a traditional brick-and-mortar drugstore, and Rite Aid agreed not to offer or sell products or services on the Internet other than through our website.

We are required to purchase our pharmaceutical inventory through Rite Aid, unless we are able to obtain better overall terms from another vendor. This
arrangement enables us to take advantage of Rite Aids volume discounts and favorable credit terms. To date, we have not been able to obtain more favorable overall terms from any other supplier, and we currently expect that we will continue to
purchase our pharmaceutical products inventory through Rite Aid. As a result of this agreement, Rite Aid is one of our largest suppliers. We also benefit from access to many of Rite Aids relationships with insurance companies and PBMs, which
enables us to meet the needs of more customers because of the availability of insurance coverage to those customers.

We license certain
Rite Aid information technology and pharmacy systems, which we currently use to adjudicate and process local pharmacy orders.



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Competition

The market for health, beauty, wellness, vision, and pharmacy products is intensely competitive and highly fragmented. Our competitors in the OTC segment include chain drugstores, mass market retailers, warehouse clubs, supermarkets, and,
with respect to prestige beauty, health, and spa products, specialty retailers and major department stores. In our mail-order pharmacy and local pick-up pharmacy segments, we compete with chain drugstores, PBMs, insurers and other health care
providers, mail-order prescription drug providers, and other online pharmacies, both domestic and foreign. Foreign online pharmacies and rogue online pharmacies can often sell drugs to U.S. residents at a lower price because they do not
comply with U.S. pharmacy regulations, are not subject to U.S. regulatory oversight, or both. Our competitors in the vision segment include other online providers of contact lenses, national optical chains, eye care professionals, and mass-market
retailers and warehouse clubs that provide prescription vision services. In addition, we compete with Internet portals and online service providers that feature shopping services and with other online or mail-order retailers that offer products
within one or more of our business segments.

We believe that the principal competitive factors in our market segments include: brand
awareness and preference, company credibility, product selection and availability, convenience, price, actual or perceived value, website features, functionality and performance, ease of purchasing, customer service, privacy, quality and quantity of
information supporting purchase decisions (such as product information and reviews), and reliability and speed of order shipment.

Intellectual Property

We regard our intellectual property as critical to our future success, and we rely on a combination of patent, copyright, trademark,
service mark, and trade secret laws, as well as contractual restrictions to establish and protect our proprietary rights in products and services. We own a number of domain names, hold three patents and have applied for seven others, have registered
several trademarks, and have filed applications for the registration of a number of our other trademarks and service marks in the United States as well as several other countries. We have licensed in the past, and expect to license in the future,
some of our proprietary rights to third parties. For example, Amazon.com has the right to license our technology, and we have granted nonexclusive rights to our trademarks and copyrighted material in connection with advertising and affiliate
relationships.

Seasonality

Our OTC
and vision businesses are subject to seasonal variations in demand. Historically, the fourth quarter of each year has been our strongest OTC sales quarter, primarily because of increased online shopping and our greater marketing efforts during the
holiday season as well as increased purchases by customers using funds from flexible spending accounts. In addition, the third quarter of each year has been our strongest vision sales quarter, primarily because of the increased purchases of contact
lens for back-to-school. We do not believe that our mail-order pharmacy or local pick-up pharmacy business segments are substantially affected by seasonality.

Employees

As of December 30, 2007, we had 850 full-time employees.However, employment levels fluctuate due to
seasonal variations in our OTC business, and we hire independent contractors and temporary employees as needed to address demand. None of our employees is represented by a labor union, and we consider our employee relations to be good.

Available Information

We file with, and furnish
to, the Securities and Exchange Commission, or SEC, periodic reports, proxy statements, and other information. We make these documents available, free of charge, on our website at www.drugstore.com(under Corporate Information) as soon as
reasonably practicable after we electronically file them with, or furnish them to, the SEC.



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Directors and Officers

The following tables provide information regarding our directors and officers as of the date of this annual report:

Directors



|                      |  |     |  |                                                                                  
|--------------------- |  | --- |  | ---------------------------------------------------------------------------------
|Name                  |  | Age |  | Position                                                                         
|Dawn G. Lepore        |  | 53  |  | President, Chief Executive Officer and Chairman of the Board, drugstore.com, inc.
|Richard W. Bennet III |  | 55  |  | Co-Chief Executive Officer, CCA Global Partners                                  
|Geoffrey R. Entress   |  | 44  |  | Venture Partner, Madrona Venture Group                                           
|Jeffrey M. Killeen    |  | 54  |  | Chairman and CEO, GlobalSpec, Inc.                                               
|William D. Savoy      |  | 43  |  | Consultant                                                                       
|Gregory S. Stanger    |  | 43  |  | Venture Partner, Technology Crossover Ventures                                   

Executive Officers



|                |  |     |  |                                                              
|--------------- |  | --- |  | -------------------------------------------------------------
|Name            |  | Age |  | Position                                                     
|Dawn G. Lepore  |  | 53  |  | President, Chief Executive Officer, and Chairman of the Board
|Thère du Pont   |  | 41  |  | Sr. Vice President, Operations, and Chief Financial Officer  
|Robert Hargadon |  | 51  |  | Vice President, Human Resources                              
|Yukio Morikubo  |  | 48  |  | Vice President, Strategy, General Counsel and Secretary      

Dawn G. Leporehas served as President, Chief Executive Officer and Chairman of the Board
of drugstore.com since October 2004. Ms. Lepore served as Vice ChairmanActive Trader, Technology, Operations, Administration and Business Strategy of The Charles Schwab Corporation, or CSC, from August 2003 to October 2004. CSC, through
Charles Schwab & Co., Inc., or Schwab, and its other operating subsidiaries, is a financial services firm. Ms. Lepore served as Vice ChairmanTechnology, Active Trader, Operations, and Administration of CSC and Schwab from May
2003 until August 2003, as Vice ChairmanTechnology, Operations and Administration of CSC and Schwab from July 2002 until May 2003, as Vice ChairmanTechnology and Administration of CSC and Schwab from 2001 to 2002, as Vice Chairman and
Chief Information Officer of CSC and Schwab from 1999 to 2001 and as Executive Vice President and Chief Information Officer of CSC and Schwab from 1993 to 1999. She joined Schwab in 1983. Ms. Lepore serves as a director of eBay Inc. and has
been nominated to stand for election to the board of The New York Times Company in April 2008.

Thère du Pont has served as
Senior Vice President, Operations and Chief Financial Officer for drugstore.com since May 2007. Prior to joining drugstore.com, Mr. du Pont served in several key positions, including President and Chief Financial Officer, at Wawa, Inc., a
retailer operating more than 550 convenience stores in the Mid-Atlantic region. Mr. du Pont is a member of the Board of Directors of the DuPont Company, where he serves on the audit, compensation, and science and technology committees. He is
also President of the Longwood Foundation.

Robert Hargadonhas served as Vice President, Human Resources of drugstore.com since
November 2006. Mr. Hargadon served as the General Manager, Corporate Learning and Development for Microsoft Corporation from 2005 to 2006. He was at Boston Scientific, a medical device developer and manufacturer, from 1997 to 2005, initially as
the Vice President, International Human Resources and later as the Vice President, U.S. Human Resources. From 1993 to 1997, Mr. Hargadon was the Vice President, Training and Development, Retail for Fidelity Investments, a financial services
company. He has also worked as a consultant on a wide range of leadership, human resource and organization development assignments.



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Yukio Morikubohas served as Vice President, General Counsel and Secretary of drugstore.com since
November 2006 and as Vice President, Strategy since April 2007. From April 2005 to September 2006, Mr. Morikubo was Vice President, General Counsel and Corporate Secretary of Advanced Digital Information Corporation, a provider of intelligent
data storage hardware and software solutions that was acquired in August 2006 by Quantum Corporation. He served as Chief Counsel, International of Cingular Wireless, LLC, formerly AT&T Wireless Services, Inc., a wireless service provider, from
1996 to 1999 and again from 2000 until April 2005. Mr. Morikubo previously practiced with the law firm of Perkins Coie LLP and served as an auditor and tax consultant with KPMG LLP.

Non-Executive Officers

Luke Friang has served as Vice President and Chief Information Officer of drugstore.com since January 2006. From 2001 to 2005, Mr. Friang was senior director of e-commerce technologies at Costco Wholesale Corporation, a
membership warehouse retailer. Mr. Friang held a variety of positions from 1997 to 2001 in the e-commerce technology operations groups at The Spiegel Group, an apparel and home furnishings retailer.

Julie Johnstonhas served as Vice President, OTC Merchandising of drugstore.com since December 2006 and as the Senior Category
Manager for Personal Care with drugstore.com from 2000 to 2006. From 1992 to 1999, Ms. Johnston served in a number of positions at Sears, Roebuck and Co., an international department store company, including Senior Buyer from 1996 to 1999.

Ronald E. Kelly has served as Vice President, Customer Care and Logistics of drugstore.com since June 2006, and as Senior
Director of Site Development and Customer Care and Logistics for drugstore.com from 2003 to 2006. From 2001 to 2003, he served as Director of Customer Care with drugstore.com. From 1999-2001, Mr. Kelly served as a Senior Financial Analyst and
later as Director of Procurement for drugstore.com.

David Lonczak was named as our Chief Marketing Officer in March 2007 and has
served as our Vice President, Marketing since December 2006. In early 2006, Mr. Lonczak began serving as Senior Director of Marketing in Pharmacy for drugstore.com, and served as General Manager of Vision for drugstore.com from 2005 to 2006.
From 2002 to 2005, Mr. Lonczak served in a number of positions with Cingular Wireless, LLC, formerly AT&T Wireless Services, Inc., a wireless service provider, including Vice President, eCommerce from 2004 to 2005.

Kathleen McNeill has served as our Vice President of Beauty since December 2006. She joined drugstore.com in June 2006 as our General Manager,
Beauty. From 2005 to June 2006, Ms. McNeill served as Vice President of Flagship Stores with Bath and Body Works, a division of Limited Brands, Inc., a specialty retail company. From 2000 to 2005, Ms. McNeill served in a number of
positions, including Skincare Merchandise manager with Sephora, USA, Inc., the cosmetic retailer division of Moët Hennessy Louis Vuitton, an international luxury products retailer.

Robert Potterhas served as Vice President, Chief Accountant of drugstore.com since December 2006, and as Senior Director and Corporate Controller
for drugstore.com from 2004 to 2006. Prior to joining drugstore.com, Mr. Potter served as Corporate Controller for Midstream Technologies, Inc., a technology company, from 2000 to 2004.

Tracy Wright has served as Vice President of Financial Planning and Analysis since August 2007, and as Senior Director of Financial Planning and
Analysis from 2003 to July 2007. Prior to joining drugstore.com, Ms. Wright held financial leadership roles at Western Wireless International, Freeinternet.com, and PriceWaterhouseCoopers.



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|ITEM 1A. | RISK FACTORS
|-------- | ------------

You should carefully consider the
following risks and uncertainties associated with our company and ownership of our securities. If any of the following risks actually occurs, our business, financial condition, or operating results could be materially adversely affected. This could
cause the trading price of our common stock to decline, and you could lose all or part of your investment. Some statements in this annual report (including some of the following risk factors) are forward-looking statements. See the section entitled
Special Note Regarding Forward-Looking Statements in Part I, Item 1 of this annual report.

We have a history of generating
significant losses, and may not be able to sustain profitability.

We have an accumulated deficit of $761.9 million through
December 30, 2007. To date, we have not been profitable, and we may never achieve profitability on a full-year or consistent basis. We expect to continue to incur net losses in the first quarter of 2008, and possibly longer. As a result, our
stock price may decline and stockholders may lose all or a part of their investment in our common stock.

We may experience significant fluctuations
in our operating results and rate of growth.

Our evolving business model and the unpredictability of our industry make it difficult
for us to forecast accurately the level or source of our revenues and our rate of growth. We believe that, because of these factors, historical trends and quarter-to-quarter comparisons of our operating results are not necessarily meaningful and
should not be relied on as an indicator of our future performance. In the past, our operating results have sometimes been, and it is likely that in some future quarter or quarters they will be, below the expectations of investors and securities
analysts. In that event, the price of our common stock may fall substantially, and stockholders may lose all or a part of their investment.

Our
revenue growth and profitability depends on the continued growth of demand for the products we offer.

Demand for many of our
products, and, therefore, our business, is affected by changes in consumer preferences, general economic and business conditions, and world events. For example, macro-economic trends in the United States and abroad, threatened or actual terrorist
attacks or armed hostilities (or the resulting security concerns), or natural disasters could create economic and consumer uncertainty and delays in and increased costs of product shipments to and from us, which may decrease demand. A softening of
demand, for whatever reason, may result in decreased revenue or growth, which could prevent us from achieving or sustaining profitability. Revenue growth or profitability may not be sustainable and our company-wide and by-segment percentage growth
rates may decrease in the future.

Our revenues and operating results may vary significantly from quarter to quarter due to a number of
factors, including:



| |  |  | our ability to retain and increase sales to existing customers, attract new customers, and satisfy our customers demands;
| | - |  | --------------------------------------------------------------------------------------------------------------------------



| |  |  | the frequency and size of customer orders and the quantity and mix of products our customers purchase;
| | - |  | ------------------------------------------------------------------------------------------------------



| |  |  | changes in consumer acceptance and usage of the Internet, online services, and e-commerce;
| | - |  | ------------------------------------------------------------------------------------------



| |  |  | the price we charge for our products and for shipping those products, or changes in our pricing policies or the pricing policies of our competitors;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the extent to which we offer free shipping or other promotional discounts to our customers;
| | - |  | -------------------------------------------------------------------------------------------



| |  |  | our ability to acquire merchandise, manage inventory, and fulfill orders;
| | - |  | -------------------------------------------------------------------------



| |  |  | technical difficulties, system downtime, or interruptions;
| | - |  | ----------------------------------------------------------



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| |  |  | timing and costs of upgrades and developments in our systems and infrastructure;
| | - |  | --------------------------------------------------------------------------------



| |  |  | timing and costs of marketing and other investments;
| | - |  | ----------------------------------------------------



| |  |  | disruptions in service by shipping carriers;
| | - |  | --------------------------------------------



| |  |  | the introduction by our competitors of websites, products, or services;
| | - |  | -----------------------------------------------------------------------



| |  |  | the extent of reimbursements available from third-party payors;
| | - |  | ---------------------------------------------------------------



| |  |  | an increase in the price of fuel used in the transportation of packages, or an increase in the prices of other energy products, primarily natural gas and
electricity, which are used in our operating facilities;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | changes in the mix of products purchased by our customers. For example, if customers purchase a higher proportion of generic prescription drugs, which have lower
prices and higher margins than branded drugs, our net sales may decrease while our product margins increase. Moreover, if our OTC net sales do not grow as much as we anticipate or the proportion of OTC net sales compared to net sales in other
segments is lower than we anticipate, our margins will be lower than we currently plan;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the effects of strategic alliances, potential acquisitions, and other business combinations, and our ability to successfully and timely integrate them into our
business; and
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | changes in government regulation.
| | - |  | ---------------------------------

In addition, our operating expenses are largely based on anticipated revenue trends and a high percentage of our expenses are fixed in the short term. As a result, a delay in generating or recognizing revenue for any reason could result in
substantial additional operating losses.

A portion of our revenues is also seasonal in nature. Traditional retail seasonality affects our
OTC business, resulting in higher revenues in the fourth quarter of each year as compared to other quarters. We may be unable to manage the increased sales effectively, and increases in inventory in anticipation of holiday sales could negatively
affect our cash flow. In addition, sales of some health and beauty products are driven, to some extent, by seasonal purchasing patterns and seasonal product changes, such as diet products, cold and flu medications, and products with holiday-specific
varieties. Consumer fads and other changes in consumer trends may also cause shifts in purchasing patterns, resulting in significant fluctuations in our operating results from one quarter to the next.

We face significant competition from both traditional and online retailers.

The market segments in which we compete are rapidly evolving and intensely competitive, and we have many competitors in different industries, including both the retail and e-commerce services industries. These
competitors include chain drugstores, mass-market retailers, warehouse clubs, supermarkets, specialty retailers, major department stores, PBMs, insurers and health care providers, mail-order pharmacies (legitimate and illegitimate), national optical
chains, eye care professionals, Internet portals and online service providers that feature shopping services, and various online stores that offer products within one or more of our product categories. Many of our current and potential competitors
have longer operating histories, larger customer bases, greater brand recognition, and significantly greater financial, marketing, and other resources than we have. They may be able to secure merchandise from vendors on more favorable terms, operate
with a lower cost structure, adopt more aggressive pricing policies, or devote more resources to technology development and marketing than we do. In addition, other companies in the retail and e-commerce service industries may enter into business
combinations or alliances that would strengthen their competitive positions and prevent them, their affiliated companies, or their strategic partners from entering into relationships with us. An inability to enter into or maintain relationships with
major PBMs, insurance companies, or managed care organizations could be a major competitive disadvantage to us.

As various Internet market
segments obtain large, loyal customer bases, participants in those segments may expand into the market segments in which we operate. In addition, new and expanded Web technologies may



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further intensify the competitive nature of online retail and allow our competitors to duplicate many of the products, services, and content offered on our
site. We believe that the Internet facilitates entry into the retail market and comparison shopping and renders it inherently more competitive than conventional retailing formats. We expect competition in the e-commerce channel to intensify, and
this increased competition may reduce our ability to grow and, as a result, reduce our revenue, increase our operating expenses, or both, and harm our business.

In addition, we face competition from online pharmacies outside the United States. Although it is currently illegal to re-import prescription drugs into the United States from any foreign country, a growing number of
U.S. consumers seek to fill their prescriptions through Canadian and other foreign online pharmacies, and a number of state and local governments have set up websites directing their constituents to Canadian pharmacies. The U.S. Food and Drug
Administration, or FDA, has taken only limited action to date, and may not take aggressive action in the future, against those who illegally re-import prescription drugs or support or facilitate illegal re-importation. In the U.S. Congress,
legislation allowing for re-importation of prescription drugs by individuals for personal use has repeatedly been introduced. If such legislation were to be enacted, or if consumers increasingly use foreign-based online prescription drug websites
instead of U.S.-based online pharmacies, such as ours, to fill their prescription needs, our business and operating results could be harmed.

We may
be unable to increase the migration of consumers of health, beauty, vision, and pharmacy products from brick-and-mortar stores to our online solution, which would harm our revenues and prevent us from becoming profitable.

If we do not continue to attract and retain higher volumes of online customers to our Internet stores at a reasonable cost, we will not be able to
increase our revenues or achieve consistent profitability. Our success depends on our ability to continue to convert a large number of customers from traditional shopping methods to online shopping for health, beauty, wellness, vision, and pharmacy
products. Specific factors that could prevent widespread customer acceptance of our online solution include:



| |  |  | shipping charges, which do not apply to purchases made at a brick-and-mortar store;
| | - |  | -----------------------------------------------------------------------------------



| |  |  | delivery time associated with Internet orders, as compared to the immediate receipt of products at a brick-and-mortar store;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------



| |  |  | delays in deliveries to customers, particularly our West Coast customers;
| | - |  | -------------------------------------------------------------------------



| |  |  | lack of consumer awareness of our websites;
| | - |  | -------------------------------------------



| |  |  | additional steps and delays in verifying prescriptions and ensuring insurance coverage for prescription products;
| | - |  | -----------------------------------------------------------------------------------------------------------------



| |  |  | non-participation in the networks of some insurance carriers and PBMs;
| | - |  | ----------------------------------------------------------------------



| |  |  | regulatory restrictions or reform at the state and federal levels that could affect our ability to serve our customers;
| | - |  | -----------------------------------------------------------------------------------------------------------------------



| |  |  | the general acceptance or legalization of prescription drug re-importation;
| | - |  | ---------------------------------------------------------------------------



| |  |  | customer concerns about the security of online transactions, identity theft, or the privacy of their personal information;
| | - |  | --------------------------------------------------------------------------------------------------------------------------



| |  |  | product damage from shipping or shipments of wrong or expired products from us or other vendors, resulting in a failure to establish, or loss of, customers
trust in buying drugstore items online;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | inability to serve the acute care needs of customers, including emergency prescription drugs and other urgently needed products;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------



| |  |  | delays in responses to customer inquiries;
| | - |  | ------------------------------------------



| |  |  | difficulties or delays in returning or exchanging orders; and
| | - |  | -------------------------------------------------------------



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| |  |  | activity that diminishes a users online experience or subjects online shoppers to security risks, such as viruses, spam, spyware, phishing (spoofing e-mails
directed at Internet users), denial of service attacks directed at Internet service providers and online businesses, and breaches of data security.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

If our marketing efforts are not effective at attracting and retaining customers at an acceptable cost, we will be unable to achieve consistent profitability.

If we do not maintain our brand and continue to increase awareness of our products and services, we may not build a critical mass of customers. Promoting
and positioning our brand depends largely on the success of our marketing efforts and our ability to provide consistent, high quality customer experiences. We believe that, because we are a small company with low public brand awareness, achieving
significant market awareness will require significant marketing expense. To promote our brand and our products and services, we have incurred and expect to continue to incur substantial expense in our marketing efforts both to attract and to retain
customers. Our promotional activities may not be effective at building our brand awareness and customer base to the extent necessary to generate sufficient revenue to become consistently profitable. For example, we spent over $5 million during 2005
on a new brand campaign, and we determined that the brand campaign did not produce results quickly enough to serve our near-term profitability goals. Search engine and other online marketing initiatives comprise a substantial part of our marketing
efforts, and our success depends in part on our ability to manage costs associated with these initiatives, or to find other channels to acquire and retain customers cost-effectively. The demand for and cost of online advertising has been increasing
and may continue to increase. An inability to acquire and retain customers at a reasonable cost would increase our operating costs and prevent us from maintaining profitability.

Our network and communications systems are vulnerable to system interruption and damage, which could harm our operations and reputation.

Our ability to receive and fulfill orders promptly and accurately is critical to our success and largely depends on the efficient and uninterrupted
operation of our computer and communications hardware and software systems. We experience periodic system interruptions that impair the performance of our transaction systems or make our websites inaccessible to our customers. These systems
interruptions may prevent us from efficiently accepting and fulfilling orders, sending out promotional e-mails and other customer communications in a timely manner, introducing new products and features on our website, promptly responding to
customers, or providing services to third parties. Frequent or persistent interruptions in our services could cause current or potential customers to believe that our systems are unreliable, which could cause them to avoid our websites, drive them
to our competitors, and harm our reputation. To minimize future system interruptions, we need to continue to add software and hardware and to improve our systems and network infrastructure to accommodate increases in website traffic and sales
volume, to replace aging hardware and software, and to make up for several years of underinvestment in technology. We may be unable to promptly and effectively upgrade and expand our systems and integrate additional functionality into our existing
systems. Any unscheduled interruption in our services, especially during the holiday shopping season, could result in fewer orders, additional operating expenses, or reduced customer satisfaction, any of which would harm our revenues and operating
results and could delay or prevent our becoming consistently profitable. In addition, the timing and cost of upgrades to our systems and infrastructure may substantially affect our ability to maintain profitability.

Our systems and operations, and those of our suppliers and Internet service providers, are vulnerable to damage or interruption from fire, flood,
earthquakes, power loss, server failure, telecommunications and Internet service failure, acts of war or terrorism, computer viruses and denial-of-service attacks, physical or electronic break-ins, sabotage, and similar events. Any of these events
could lead to system interruptions, service delays, and loss of critical data for us, our suppliers, or our Internet service providers, and could prevent us from accepting and fulfilling customer orders. For example, our Internet service provider
recently experienced network outages that caused our website to be unavailable for several hours. Any significant interruption in the availability or functionality of our websites or our customer processing, distribution, or communications systems,



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for any reason, could seriously harm our business, financial condition, and operating results. While we do have backup systems for some aspects of our
operations, we do not have fully redundant backup systems or a formal disaster recovery plan. Our business interruption insurance may be inadequate to compensate for all losses that may occur.

All of our fulfillment operations and inventory are located in our distribution facilities, and any significant disruption of these centers operations would
hurt our ability to make timely delivery of our products.

We conduct all of our fulfillment operations from our distribution
facility in Swedesboro, New Jersey and Ferndale, Washington. Our primary distribution center in New Jersey and our inventory storage facility in Logan Township, New Jersey house our entire product inventory except for our vision products, which are
housed at our Washington facility. A natural disaster or other catastrophic event, such as an earthquake, fire, flood, severe storm, break-in, server or systems failure, terrorist attack, or other comparable event at either of these facilities, and
in particular our New Jersey facilities, would cause interruptions or delays in our business and loss of inventory and could render us unable to process or fulfill customer orders in a timely manner, or at all. Further, we have no formal disaster
recovery plan, and our business interruption insurance may not adequately compensate us for losses that may occur. In the event that a significant part of either of these facilities, and in particular our New Jersey facilities, were destroyed or our
operations were interrupted for any extended period of time, our business, financial condition, and operating results would be harmed.

If we are
unable to optimize management of our distribution centers, we may be unable to meet customer demand.

Our ability to meet customer
demand may be significantly limited if we do not successfully operate our distribution centers. Because it is difficult to predict sales volume, we may be unable to manage our facilities in an optimal way, which may result in excess or insufficient
inventory, warehousing, fulfillment, or distribution capacity. In addition, failure to control product damage and shrinkage effectively through security measures and inventory management practices could adversely affect our operating margins. Our
margins and revenues may also be affected if we are unable to obtain products from manufacturers and wholesalers timely and on favorable terms. In addition, if we need to increase our distribution capacity sooner than anticipated, that expansion
would require additional financing that may not be available to us on favorable terms when required, or at all.

Under our distribution
agreement with GNC, we maintain an inventory of GNCs products in our primary distribution center, thereby increasing the complexity of tracking inventory in, and the operation of, our distribution center. Our failure to properly handle
GNCs inventory that we hold would result in unexpected costs and other harm to our business and reputation.

We need to manage changing and
expanding operations.

Over the past several years, we have significantly expanded our operations and anticipate that we will
continue to expand. Our past growth has placed, and we expect that our anticipated future operations and expansion will continue to place, a significant strain on our managerial, operational, financial, and other resources. Some of the
administrative and operational challenges we have faced in the past as a result of our expansion and seasonal growth include the management of an expanded number of product offerings; the assimilation of systems and technologies of acquired
companies; increased pressure on our senior management; and increased demand on our systems and internal controls. Our ability to manage our operations and expansion effectively depends on the continued development and implementation of plans,
systems, and controls that meet our operational, financial, and management needs. If we are unable to develop or implement these plans, systems, or controls or otherwise manage our operations and growth effectively, we will be unable to increase
gross margins or achieve consistent profitability, and our business will be harmed.



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The seasonality of our business places increased strain on our operations.

We expect the largest amount of our net sales to occur during our fourth quarter. If we do not stock or restock popular products in sufficient amounts
such that we fail to meet customer demand, it could significantly affect our revenue and our future revenue. If we overstock products, we may be required to take significant inventory markdowns or write-offs, which could reduce our gross margins. We
may experience an increase in our shipping cost due to complimentary upgrades, split-shipments, and additional long-zone shipments necessary to ensure timely delivery for the holiday season. If our systems and processes are not prepared to address
peak volumes during high demand seasons, holidays, and events, we may experience system interruptions that make our websites unavailable or prevent us from efficiently fulfilling orders, which may reduce the volume of goods we sell and the
attractiveness of our products and services. In addition, we may be unable to staff our distribution centers adequately during these peak periods, and delivery companies may be unable to meet the seasonal demand.

We are dependent on a limited number of fulfillment and distribution partners. If we are unable to obtain shipments of product from our vendors and deliver
merchandise to our customers in a timely and cost-effective manner, our business and results of operations would be harmed.

We are
obligated to purchase all of our pharmaceutical products through Rite Aid, unless we are able to obtain better overall terms from another vendor. Our business could be significantly disrupted if Rite Aid were to breach its contract or suffer adverse
developments that affect its ability to supply products to us. If for any reason Rite Aid is unable or unwilling to supply products to us in sufficient quantities and in a timely manner, we may not be able to secure alternative fulfillment partners
on acceptable terms in a timely manner, or at all.

We cannot control all of the various factors that might affect our timely and
cost-effective procurement of products from our vendors and delivery of products to our customers. We also rely on a limited number of third-party carriers for shipments of products to and from our distribution facilities and to customers. We are
therefore subject to the risks, including increased fuel costs, security concerns, labor disputes, union organizing activity, and inclement weather, associated with our carriers ability to provide product fulfillment and delivery services to
meet our distribution and shipping needs. Failure to procure and deliver merchandise, either to us or to our customers, in a timely and accurate manner would harm our reputation, the drugstore.com brand, our business, and our results of operations.
In addition, any increase in fulfillment costs and expenses could adversely affect our business and operating results.

We have significant inventory
risk.

We must maintain sufficient inventory levels to operate our business successfully and to meet our customers
expectations that we will have the products they order in stock. However, we must also guard against the risk of accumulating excess inventory. We are exposed to significant inventory risks as a result of rapid changes in product cycles, changes in
consumer tastes, uncertainty of success of product launches, seasonality, manufacturer backorders, and other vendor-related problems. In order to be successful, we must accurately predict these trends and events, which we may be unable to do, and
avoid over- or under-stocking products. In addition, demand for products can change significantly between the time product inventory is ordered and the time it is available for sale. When we begin selling a new product, it is particularly difficult
to forecast product demand accurately. A failure to optimize inventory would increase our expenses if we have too much inventory, and would harm our margins by requiring us to make split shipments for backordered items or pay for expedited delivery
from the manufacturer if we had insufficient inventory. In addition, we may be unable to obtain certain products for sale on our websites as a result of general shortages (for example, in the case of some prescription drugs), manufacturer policies
(for example, in the case of some contact lenses and prestige beauty items), manufacturer or distributor problems, or popular demand. Failure to have inventory in stock when a customer orders it could cause us to lose that order or that customer.
The acquisition of some types of inventory, or inventory from some of our sources, may require significant lead time or prepayment, and this inventory may not



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be returnable. We carry a broad selection of products and significant inventory levels of a substantial number of products, and we may be unable to sell this
inventory in sufficient quantities or during the relevant selling seasons. The occurrence of one or more of these inventory risks may adversely affect our business and operating results.

Our vendor relationships subject us to a number of risks.

We have significant vendors that
are important to our sourcing of merchandise. We do not have long-term arrangements with most of our vendors to guarantee availability of merchandise, particular payment terms, or extension of credit limits. If our current vendors were to stop
selling merchandise to us on acceptable terms, we may not be able to acquire merchandise from other vendors in a timely and efficient manner and on acceptable terms, or at all.

Any errors in filling or packaging the prescription drugs or contact lenses we dispense may expose us to liability and negative publicity.

Errors relating to prescriptions, dosage, and other aspects of the prescription medication and contact lens dispensing process may result in liability for
us that our insurance may not cover. Because we distribute pharmaceutical products and contact lenses directly to the consumer, we are one of the most visible participants in the distribution chain and therefore have increased exposure to liability
claims.

Our pharmacists are required by law to offer counseling, without additional charge, to our customers about medication, dosage,
delivery systems, common side effects, and other information deemed significant by the pharmacists. Our pharmacists may have a duty to warn customers regarding any potential adverse effects of a prescription drug if the warning could reduce or
negate those effects. This counseling is in part accomplished through e-mails to our customers and inserts included with the prescription, which may increase the risk of miscommunication because the customer is not personally present to receive the
counseling or advice or may not have provided us with all relevant information. Although we also post product information on our website, customers may not read this information. Providing information on pharmaceutical and other products creates the
potential for claims to be made against us for negligence, personal injury, wrongful death, product liability, malpractice, invasion of privacy, or other legal theories based on our product or service offerings. Our general liability, product
liability, and professional liability insurance may not cover potential claims of this type or may not be adequate to protect us from all liabilities that may be imposed if any such claims were to be successful.

Errors by either us or our competitors may also produce significant adverse publicity either for us or for the online pharmacy or vision industries in
general. Because of the significant amount of press coverage on Internet retailing and online pharmacies, we believe that we are subject to a higher level of media scrutiny than other pharmacy product channels. The amount of negative publicity that
we or the online pharmacy or vision industries receive as a result of pharmacy or prescription processing errors could be disproportionate in relation to the negative publicity received by other pharmacies or eye care professionals making similar
mistakes. We have no control over the pharmacy practices of our competitors, and we cannot ensure that our pharmacists or our prescription processing operate completely without error. We believe customer acceptance of our online shopping experience
is based in large part on consumer trust, and errors by us or our competitors and related negative publicity could erode this trust or prevent it from growing. This could result in an immediate reduction in the amount of orders we receive, adversely
affect our revenue growth, and harm our business and operating results.

Security breaches could damage our reputation, expose us to liability, or
otherwise harm our business.

Our security measures may not prevent security breaches that could harm our business. To succeed, we
must provide a secure transmission of confidential information over the Internet and protect the confidential customer and patient information we retain, such as credit card numbers and prescription records. A third party who



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compromises or breaches the physical and electronic security measures we use to protect transaction data and customer records could misappropriate
proprietary information, cause interruptions in our operations, damage our computers or those of our customers, or otherwise harm our business. Any of these could harm our reputation and expose us to a risk of loss or litigation and possible
liability. We may need to expend significant resources to protect against security breaches or to address problems caused by breaches, and our insurance may not be adequate to reimburse us for losses caused by security breaches.

Our relationship with Rite Aid involves many risks and restricts our ability to promote, contract with, or operate traditional retail stores.

In June 1999, we entered into a series of agreements with Rite Aid that expire in June 2009. These agreements involve many aspects of our respective
businesses and the operation of our respective websites, the fulfillment of orders, and the extension of Rite Aids insurance relationships to cover prescriptions processed by us. Our local pick-up pharmacy segment, under which our customers
can pick up prescriptions at any Rite Aid store, depends on our relationship with Rite-Aid. If our ability to offer customers a local pick-up option were adversely affected by changes in Rite-Aids operations or in our relationship with
Rite-Aid, our ability to generate revenue from local pick-up pharmacy sales would be reduced or eliminated. This could occur, for example, if we are unable to establish a relationship with another company to offer local pick-up of prescriptions, or
if Rite Aid were to close a significant number of its stores. In addition, we currently use Rite Aids systems to process prescription orders in both our local pick-up pharmacy segment and our mail-order pharmacy segment. If we were unable to
maintain our relationship with Rite Aid and could not feasibly implement an alternative method for processing prescriptions, through either our own systems or those of a third party, we would be unable to maintain our pharmacy operations. The loss
of our pharmacy sales, which comprised approximately 35% of our net sales in fiscal 2007, would greatly reduce our revenue and harm our business.

Our arrangement with Rite Aid is complex and requires substantial effort and attention to operate and manage successfully. We may not be able to accommodate changes that Rite Aid may make to its systems that we use, which may limit our
ability to operate our business.

While Rite Aid has committed to promoting drugstore.com in its stores and in its advertising, we do not
control the choice of ads in which we are featured, and this form of advertising may not result in additional drugstore.com customers. In addition, a substantial alteration of Rite Aids marketing efforts, or a breach by Rite Aid of its
marketing obligations, could adversely affect our revenues and harm our business. While our relationship with Rite Aid substantially broadens our ability to provide prescription medications to consumers with insurance reimbursement plans, it may not
allow all of our potential customers to purchase these medications from drugstore.com and receive insurance reimbursement, which could adversely affect consumer perceptions of us and our revenues. In addition, our relationship with Rite Aid contains
limitations on the scope of our activities, including restrictions on our ability to promote, contract with, or operate traditional retail stores, and the prohibition on our ability to become a PBM. We have also agreed not to contract with another
traditional retail store to fill pharmacy product orders we receive unless a Rite Aid store is not conveniently located near a customer. These restrictions could limit our flexibility and ability to grow our business if our relationship with Rite
Aid is not successful.

If we fail to maintain or enhance our strategic relationships to help promote our website and expand our product offerings,
our development could be hindered.

We believe that our strategic relationships with Rite Aid, Internet portals, third-party
distributors, and manufacturers are critical to attract customers, to facilitate broad market acceptance of our products and the drugstore.com brand, and to enhance our sales and marketing capabilities. If we are unable to develop or maintain key
relationships, our ability to attract customers would suffer and our business would be adversely affected. In addition, we are subject to many risks beyond our control that influence the success or failure of our



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strategic partners. Our business could be harmed if any of our strategic partners were to experience financial or operational difficulties or if other
corporate developments adversely affect their performance under our agreements.

We may be unable to obtain the additional capital we need in the
future to support our growth.

Our available funds may not be sufficient to meet all of our long-term business development
requirements, and we may seek to raise additional funds through public or private debt or equity financings. Any additional financing that we may need may not be available on terms favorable to us, or at all. If adequate funds are not available or
are not available on acceptable terms, our strategic flexibility or ability to develop and grow our business may be significantly limited.

Expanding
the breadth and depth of our product and service offerings is expensive and difficult, and we may receive no benefit from our expansion.

We intend to continue to expand the breadth and depth of our product and service offerings by promoting new or complementary products or sales formats. Expansion of our offerings in this manner could require significant additional
expenditures and could strain our management, financial, and operational resources. For example, we may need to incur significant marketing expenses, develop relationships with new fulfillment partners or manufacturers, or comply with new
regulations. We may be unable to expand our product and service offerings or sales formats in a cost-effective or timely manner, and any new offerings or formats may not generate satisfactory revenues to offset the costs involved. Furthermore, any
new product or service offering or sales format that is not favorably received by consumers could damage the reputation of our brand. A lack of market acceptance of our efforts or our inability to generate sufficient revenues to offset the cost of
expanded offerings could harm our business.

We face uncertainty related to pharmaceutical costs and pricing, which could affect our revenues and
profitability.

Pharmacy sales accounted for approximately 35% of our total revenue in fiscal year 2007. Sales of our pharmacy
products depend in part on the availability of reimbursement from third-party payors such as government health administration authorities, private health insurers, managed care organizations, PBMs, and other organizations. These organizations are
increasingly challenging the price and cost-effectiveness of medical products and services. The efforts of third-party payors to contain costs often place downward pressures on profitability from sales of prescription drugs. In addition, our
products or services may not be considered cost-effective, and adequate third-party reimbursement may not be available to enable us to maintain price levels sufficient to realize a profit.

In 2006, the Medicare Part D prescription drug benefit under the Medicare Prescription Drug Improvement and Modernization Act of 2003, or DIMA, became
effective. As we expected, the Medicare Part D prescription drug benefit has negatively affected, and is likely to continue to have a negative impact on, our business. Medicare Part D prescription drug coverage will likely increase the number of
senior citizens with prescription drug coverage and reduce the number of customers who pay for their prescription drugs themselves. Customers who choose to obtain coverage under a Medicare Part D plan will likely purchase fewer drugs, or no longer
purchase drugs, from us. Because we are not currently processing claims for Medicare Part D, we will be able to serve Medicare D customers only when those customers elect to purchase outside of their Medicare Part D plan and purchase their
prescriptions out-of-pocket, such as when the particular medication is not covered by the customers Medicare plans or when the customers purchase is not covered because of a deductible, co-payment, or other exclusion. Moreover, the DIMA
calls for significant changes to the formulas the Medicare program uses to calculate its payments for prescription drugs, as well as introduction of managed care elements and changes to the administration of the drug benefit program. When fully
implemented, these changes could exert downward pressure on prescription drug prices and payments by the government, even as the number of people who use the



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Medicare benefits to pay for prescription drugs increases. All of these factors could adversely affect our drug prices and dispensing fees, and ultimately
could reduce our profit margins.

In addition, our revenues from prescription drug sales may also be affected by health care reform
initiatives of federal and state governments, including proposals designed to address other government programs, prescription drug discount card programs, changes in programs providing for reimbursement for the cost of prescription drugs by
third-party payors, and regulatory changes related to the approval process for prescription drugs. These initiatives could lead to the enactment of additional federal and state regulations that may adversely affect our prescription drug sales.

If we are unable to obtain insurance reimbursement coverage for our customers, our ability to sell pharmacy products online could decrease, which
would harm our revenues.

To obtain reimbursement on behalf of our customers for the prescription products that they purchase on our
website, we must maintain relationships with insurance companies, managed health organizations, and PBMs, either directly or through our relationship with Rite Aid. Many of our direct agreements with insurance companies, PBMs, and third-party
benefits companies are short-term, may be terminated with less than 30 days prior notice, and are subject to unilateral amendment by the other party. If we are unable to establish, maintain, and leverage our direct relationships with insurers,
PBMs, and third-party benefit companies, and to the extent Rite Aid is unable to maintain its relationships or if these relationships do not extend to cover the prescriptions we process, our ability to obtain reimbursement coverage for our customers
would be reduced. This would reduce the number of customers that fill prescriptions through our website, which would harm our business, financial condition, and results of operations.

In addition, we must process each customers insurance application, which raises the costs of processing prescription orders and may delay the
customers initial prescription order. Customers may not embrace our online insurance coverage procedure.

Our future growth strategy may depend
in part on our ability to acquire complementary or strategic businesses. Any such acquisitions could result in dilution, operating difficulties, difficulties in integrating acquired businesses, and other harmful consequences.

We have acquired, and may in the future acquire, complementary or strategic businesses, technologies, services, and products as part of our strategy to
increase our net sales and customer base. The process of integrating acquisitions into our business and operations has resulted in, and may in the future result in, unforeseen operating difficulties and expenditures. Integration of an acquisition
also requires significant management resources that would otherwise be available for operation, ongoing development, and expansion of our business. To the extent we miscalculate our ability to integrate and properly manage acquired businesses,
technologies, services, and products, or we depend on the continued service of acquired personnel who choose to leave, we may have difficulty in achieving our operating and strategic objectives. In addition, we may not realize the anticipated
benefits of any acquisition.

We may be unable to identify suitable acquisition opportunities or to negotiate and complete acquisitions on
favorable terms, or at all. In addition, any future acquisitions may require substantial capital resources and we may need to obtain additional capital or financing, from time to time, to fund these activities. This could result in potentially
dilutive issuances of equity securities or the incurrence of debt, contingent liabilities, or amortization or impairment expenses related to goodwill and other intangible assets, any of which could harm our business, financial condition, and results
of operation. Sufficient capital or financing may not be available to us on satisfactory terms, or at all.



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Governmental regulation of our business could require significant expenditures, and failure to comply with
regulations could result in civil and criminal penalties.

Our business is subject to extensive federal, state and local
regulations. For example:



| |  |  | entities such as drugstore.com engaging in the practice of pharmacy are subject to numerous federal and state regulatory requirements, including those relating to
pharmacy licensing and registration, the dispensing of prescription drugs, pharmacy record keeping and reporting, and the confidentiality, security, storage, and release of patient records;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the sale, advertisement, and promotion of, among other things, prescription, OTC and homeopathic medications, dietary supplements, medical devices, cosmetics,
foods, and other consumer products that we sell are subject to regulation by the Food and Drug Administration, or FDA, the Federal Trade Commission, or FTC, the Consumer Product Safety Commission, and state regulatory authorities, as the case may
be; and
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our vision business is subject to the Fairness to Contact Lens Consumers Act and related regulations of the FTC, which requires all patients to renew their contact
lens prescriptions annually and requires third-party contact lens sellers, like Vision Direct, to verify these prescriptions in accordance with specified procedures.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

As we expand our product and service offerings and more non-pharmaceutical products become subject to FDA, FTC, and other regulation, more of our
products and services will likely be subject to regulation. In addition, regulatory requirements to which our business is subject may expand over time, and some of these requirements may have a disproportionately negative effect on Internet
retailers. For example, the federal government and a majority of states now regulate the retail sale of OTC products containing pseudoephedrine that might be used as precursors in the manufacture of illegal drugs. As a result, we are currently
unable to sell these products to customers residing in states that require retailers to obtain a physical form of identification or maintain a signature log. Some members of Congress have proposed additional regulation of Internet pharmacies in an
effort to combat the illegal sale of prescription drugs over the Internet, and state legislatures could add or amend legislation related to the regulation of nonresident pharmacies. In addition to regulating the claims made for specific types of
products, the FDA and the FTC may attempt to regulate the format and content of websites that offer products to consumers. In addition, recently proposed legislation would place severe burdens on verifying contact lens prescriptions, and such
burdens might reduce our customer base or dramatically increase our costs. Complying with regulations is time-consuming, burdensome, and expensive and could delay our introduction of new products or services.

As our website is accessible over the Internet in multiple states and other countries, and if and when we expand our marketing strategies to other
countries, we may be subject to their laws and regulations or may be required to qualify to do business in those locations. Our failure to qualify in a state or country in which we are required to do so could subject us to taxes and penalties and we
could be subject to legal actions and liability in those jurisdictions. The restrictions or penalties imposed by, and costs of complying with, these laws and regulations could harm our business, operating results, and financial condition. Our
ability to enforce contracts and other obligations in states and countries in which we are not qualified to do business could be hampered, which could harm our business.

The laws and regulations applicable to our business often require subjective interpretation, and we cannot be certain that our efforts to comply with these regulations will be deemed sufficient by the appropriate
regulatory agencies. Violations of any regulations could result in various civil and criminal penalties, including suspension or revocation of our licenses or registrations, seizure of our inventory, or monetary fines, any of which could harm our
business, financial condition, or operating results. Compliance with new laws or regulations could increase our expenses or lead to delays as we adjust our websites and operations.



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Increasing concern about privacy, spam, and the use and security of customer information could restrict our
marketing efforts and harm our business.

Internet retailers are also subject to increasing regulation and scrutiny relating to
privacy, spam, and the use and security of personal user information. These regulations, along with increased governmental or private enforcement (for example, by Internet service providers), may increase the cost of growing our business. Current
and proposed regulations and enforcement efforts may restrict our ability to collect and use demographic and personal information from users and send promotional e-mails, which could be costly or harm our marketing efforts. For example, if one or
more Internet service providers were to block our promotional e-mails to customers, our ability to generate orders and revenue could be harmed. Further, any violation of privacy, anti-spam, or data protection laws or regulations may subject us to
fines, penalties, and damages and may otherwise have a material adverse effect on our business, results of operations, and financial condition.

Restrictions imposed by, and costs of complying with, governmental regulation of the Internet and data transmission over the Internet could harm our business.

We are subject to the same federal, state, and local laws generally applicable to businesses, as well as those directly applicable to companies conducting
business online, including consumer protection laws, user privacy laws, and regulations prohibiting unfair and deceptive trade practices. In particular, many government agencies and consumers are focused on the privacy and security of medical and
pharmaceutical records. Further, the growth of online commerce could result in more stringent consumer protection laws that impose additional compliance burdens on us. Today there are an increasing number of laws specifically directed at the conduct
of business on the Internet. Moreover, due to the increasing use of the Internet, many additional laws and regulations relating to the Internet are being debated at the state and federal levels. These laws and regulations could cover issues such as
freedom of expression, pricing, user privacy, fraud, quality of products and services, taxation, advertising, intellectual property rights, and information security. Applicability of existing laws to the Internet relating to issues such as property
ownership, copyrights and other intellectual property issues, taxation, libel, obscenity, and personal privacy could also harm our business. For example, U.S. and international laws regulate our ability to use customer information and to develop,
buy, and sell mailing lists. The vast majority of these laws were adopted before the advent of the Internet, and do not contemplate or address the unique issues raised by the Internet. Those laws that do reference the Internet, such as the Digital
Millennium Copyright Act, are only beginning to be interpreted by the courts, and their applicability and reach are therefore uncertain. The restrictions imposed by, and the costs of complying with, current and possible future laws and regulations
related to businesses conducted on the Internet could harm our business, operating results, and financial condition.

We may be unable to protect our
intellectual property, and we may be found to infringe proprietary rights of others, which could harm our business, brand, and reputation.

Our success depends in substantial part on our proprietary rights, including our technology, copyrights, trademarks, service marks, trade dress, trade secrets, and similar intellectual property. We rely on a combination of patent,
trademark, trade secret, and copyright law, as well as contractual restrictions to protect our proprietary rights. Despite our efforts to protect our proprietary rights, however, unauthorized parties may attempt to copy, obtain, and use technology
or information that we regard as proprietary, such as our sales formats, the technology used to operate our website, our website content, and our trademarks. In addition, the laws of many countries do not protect our proprietary rights to the same
extent as the laws of the United States.

We own a number of domain names, hold three patents and have filed applications for seven others,
and have registered several trademarks and filed applications for a number of other trademarks in the United States and several other countries. We may be unable to secure the trademark registrations or patents for which we have applied, which could
negatively affect our business. Our competitors or others may adopt marks or service names similar to ours, which could impede our ability to build brand identity and lead to customer confusion, and owners of other registered trademarks or
trademarks that incorporate variations of our marks could bring potential trade name or trademark infringement claims against us. In addition, the laws of some foreign countries



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do not protect our proprietary rights to the same extent as do the laws of the United States, and effective patent, copyright, trademark, and trade secret
protection may not be available in such jurisdictions. Our business could be harmed if we are unable to protect or preserve the value of our trademarks, patents, copyrights, trade secrets, or other proprietary rights for any reason, or if we are
subject to any claims or customer confusion related to our intellectual property or any failure or inability to protect our proprietary rights.

Litigation or proceedings before the U.S. Patent and Trademark Office or the World Intellectual Property Organization may be necessary in the future to enforce our intellectual property rights, to protect our trade secrets and domain names,
or to determine the validity and scope of the proprietary rights of others. Any litigation or adverse priority proceeding or other efforts to protect our intellectual property could result in substantial costs and diversion of resources and could
seriously harm our business and operating results. Third parties have in the past, and may in the future, also assert claims against us alleging infringement, misappropriation, or other violations of patent, trademark, or other proprietary rights
held by them, whether or not their claims have merit. For example, one of our subsidiaries was sued over alleged copyright and trademark violations based on use of pop-up advertising, although this action was settled in June 2004 without
any material adverse effects to us. We expect that participants in our markets will be increasingly subject to infringement claims as the number of services and competitors in our industry segment grows. Any such claims, whether they are with or
without merit or are determined in our favor, could be time-consuming, result in costly litigation, divert the attention of our management, cause service upgrade delays, and harm our business or operating results. Furthermore, as a result of
infringement claims we may be required to enter into costly royalty or licensing agreements, which may not be available on terms that are acceptable to us, or at all. If a third party successfully asserts an infringement claim against us and we are
required to pay monetary damages or royalties or we are unable to obtain suitable non-infringing alternatives or license the infringed or similar intellectual property on reasonable terms on a timely basis, our business could be adversely affected.

The third-party licenses on which we rely may not continue to be available to us on commercially reasonable terms. The loss of such
licenses could require us to incur greater cost or change our business plans, either of which could harm our business.

If people or property are
harmed by the products we sell, product liability claims could damage our business and reputation.

Some of the products we sell may
expose us to product liability claims relating to personal injury, death, or property damage caused by these products and may require us to take actions such as product recalls. Any such product liability claim or product recall may result in
adverse publicity regarding us and the products we sell, which may harm our reputation. If we are found liable under product liability claims, we could be required to pay substantial monetary damages. Further, even if we successfully defend
ourselves against this type of claim, we could be forced to spend a substantial amount of money in litigation expenses, our management could be required to spend valuable time in the defense against these claims, and our reputation could suffer, any
of which could harm our business. Some of our vendors do not indemnify us against product liability. Further, our liability insurance may not be adequate to protect us from all liability that may be imposed as a result of these claims, and we cannot
be certain that insurance will continue to be available to us on economically reasonable terms, or at all. Any imposition of product liability that is not covered by vendor indemnification or our insurance could harm our business, financial
condition, and operating results.

If Internet use and the online drugstore market do not continue to grow, our ability to generate revenue will be
harmed.

Consumer use of the Internet as a medium for commerce is still subject to uncertainty. If use of the Internet as a medium
for commerce does not continue to grow or grows at a slower rate than we anticipate, our sales would be lower than expected and our business would be harmed. The number of Internet users and amount of Internet traffic continues to rise and the
Internet infrastructure may not expand fast enough to meet the increased



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levels of demand. In addition, the Internet has experienced, and is likely to experience in the future, outages, delays, and other performance problems as a
result of damage to portions of its infrastructure, increasing numbers of users, increasing bandwidth requirements, or problems caused by viruses, worms, and similar programs. These outages and delays could reduce the level of Internet usage and
traffic, which could slow our rate of growth and harm our revenues.

Further, the online market for drugstore products is still developing.
Even if use of the Internet and electronic commerce continues to increase, the rate of growth, if any, of the online drugstore market could be significantly less than the online market for other products. Our rate of revenue growth could therefore
be significantly less than other online merchants, which could delay or prevent our becoming profitable and cause our stock price to decline.

If we
do not respond to rapid technological changes, our services could become obsolete and our business would be seriously harmed.

As
the Internet and online commerce industry evolve, we must license technologies useful in our business, enhance our existing services, develop new services and technologies that address the increasingly sophisticated and varied needs of our
prospective customers and respond to technological advances and emerging industry standards and practices on a cost-effective and timely basis. We may not be able to successfully implement new technologies or adapt our web stores, proprietary
technology, and transaction-processing systems to meet customer requirements or emerging industry standards. Failure to successfully and timely do so could adversely affect our ability to build the drugstore.com brand and attract and retain
customers.

We are subject to a number of risks related to payments we accept.

We accept payments by a variety of methods, including credit cards, gift certificates, and third-party payors such as Pay Pal, Google Checkout, and Bill
Me Later. As we offer new payment options to our customers, we may be subject to additional regulations, compliance requirements, and fraud. For credit card payments and other third-party payors, we pay interchange and other fees, which may increase
over time, raising our operating costs and lowering our profit margins. We are also subject to payment card association operating rules and certification requirements, which could change or be reinterpreted to make compliance difficult or
impractical. If we fail to comply with these rules or requirements, we may be subject to fines and higher transaction fees and lose our ability to accept credit card payments from our customers or facilitate other types of online payments, and our
business and operating results could be adversely affected.

If we are required to collect sales and use taxes on the products we sell in additional
jurisdictions, we may be subject to liability for past sales and our future sales may decrease.

In accordance with current industry
practice and our interpretation of applicable law, historically, we have not collected sales and use taxes or other taxes with respect to shipments of goods into states other than Washington. However, the revenue agency of the state of New Jersey,
where our primary distribution center is located, has asserted that we owe state sales tax on some of our prior sales to New Jersey residents from January 3, 2000 to December 29, 2001. On February 19, 2008, we were informed of the
decision by the Tax Court of New Jersey against us in the case of drugstore.com, inc. vs. Director, Division of Taxation (the NJ Tax Case). The NJ Tax Case represented an appeal by us of an assessment made by the New
Jersey Division of Taxation (the Division) for $221,626 in tax, plus penalties in the amount of $11,081 and interest. The Division alleged that we failed to collect and remit sales taxes to the Division on taxable sales made in New
Jersey for the years 2000 and 2001. We did not believe that it was required to collect sales taxes on sales made to customers in New Jersey based on applicable law. In its decision, the Tax Court of New Jersey ruled otherwise. Prior to
this ruling we had not collected sales tax in New Jersey. We will appeal the Tax Courts decision in the NJ Tax Case, and we are considering our other legal options. In the meantime, we have begun collecting and remitting sales tax on
taxable New Jersey sales. If we are unsuccessful in our appeal, the State of New Jersey may expand its



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assessment to include other years for which we did not collect sales tax. The operation of our distribution centers, the operations of any future
distribution centers, our drop-shipping agreements with vendors, and other aspects of our evolving business, however, may result in additional sales and use tax collection obligations. In addition, one or more other states may successfully assert
that we should collect sales and use or other taxes on the sale of our products in that state. One or more states or the federal government may seek, either through unilateral action or through federal legislation, to impose sales or other tax
collection obligations on out-of-jurisdiction companies that engage in electronic commerce as we do. Moreover, one or more states could begin to impose sales taxes on sales of prescription products, which are not generally taxed at this time, or
impose sales taxes on sales of certain prescription products (such as those used for pets and farm animals). In either event, customers who order prescriptions at our website and pick them up at a Rite Aid store would be required to pay sales tax.
In addition, we could be subject to significant fines or other payments for any past failure to comply with tax regulations. Either of these could result in substantial tax liabilities for our past sales, decrease our ability to compete with
traditional retailers, and otherwise harm our business, financial condition, and operating results.

Currently, decisions of the U.S.
Supreme Court restrict the ability of states to collect state and local sales and use taxes with respect to sales made over the Internet. However, a number of states and the U.S. Congress have been considering various initiatives that could limit or
supersede the Supreme Courts position regarding sales and use taxes on Internet sales, and at least 18 states recently began voluntarily collecting sales taxes on Internet sales. If any of these initiatives addressed the Supreme Courts
constitutional concerns and resulted in a reversal of its current position, we could be required to collect and remit sales and use taxes in states other than Washington and New Jersey. In addition, applicable law does not currently require us to
collect sales tax on the sales of prescription medications. If this law were to change, we would be required to collect and remit sales and use taxes for prescription products. The imposition of additional tax obligations on our business by state
and local governments could create significant administrative burdens for us, decrease our future sales, and harm our cash flow and operating results.

Certain stockholders own a significant amount of our common stock, which could discourage an acquisition of drugstore.com or make removal of incumbent management more difficult.

Amazon.com beneficially owns approximately 13% of our outstanding stock, and is entitled to designate a director to serve on our board of directors,
currently Geoffrey R. Entress. Kleiner Perkins Caufield and Byers, or KPCB, owns approximately 12% of our outstanding stock, and Ziff Asset Management, L.P., or Ziff, owns approximately 10% of our outstanding stock. Because each owns a significant
percentage of our capital stock, Amazon.com, KPCB, or Ziff, or more than one of them, could significantly influence all matters requiring approval by our stockholders, including the election of directors and the approval of mergers or other business
combination transactions. Furthermore, because of these substantial equity stakes in drugstore.com, competitors of Amazon.com, KPCB, or Ziff, or other potential acquirers could decide not to merge with, or acquire, us. In addition, in the case of a
potential acquisition of drugstore.com by another party, a substantial equity stake in drugstore.com could prevent the tax-free treatment of an acquisition, making drugstore.com a less attractive acquisition candidate. In addition, if any of our
significant stockholders were to sell a substantial quantity of their holdings in a short period of time, our stock price could decline.

Our stock
price is likely to continue to fluctuate, which could result in substantial losses for stockholders.

The market price of our common
stock has been, and is likely to continue to be, extremely volatile. Our stock price could be subject to wide fluctuations in response to a number of factors, including those described in this annual report, some of which are beyond our control, and
these fluctuations could result in substantial losses for stockholders.

In the past, securities class action and derivative litigation has
often been brought against a company following periods of volatility in the market price of its securities. We have been named in such lawsuits in the past, including certain putative class action and derivative suits filed against us and certain of
our current and



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former officers and directors in 2004. Although the courts dismissed these lawsuits, we may be the target of similar litigation in the future. Securities
litigation could result in substantial costs and divert managements attention and resources, which could seriously harm our business and operating results and cause the trading price of our stock to decline.



|ITEM 1B. | UNRESOLVED STAFF COMMENTS
|-------- | -------------------------

None.



|ITEM 2. | PROPERTIES
|------- | ----------

Our principal executive offices are
located in Bellevue, Washington, where we lease approximately 53,000 square feet under a lease that expires in July 2013, with two separate five-year renewal options that, if exercised, would extend the lease expiration to July 2023. Our primary
distribution facility for our OTC and mail-order pharmacy segments is located in Swedesboro, New Jersey, where we lease approximately 270,000 square feet under a lease that expires in December 2010, with options to renew for two additional five-year
periods. We also lease an inventory storage facility in Logan Township, New Jersey for 85,000 square feet through February 2011. The distribution facility for our vision segment is located in Ferndale, Washington, where we lease approximately 16,600
square feet under a lease that expires in July 2008, with an option to renew for an additional five-year period. We lease approximately 11,500 square feet under a lease that expires in March 2011 for our principal customer care center, which is
located in Halifax, Nova Scotia, Canada.

In 2007, we made improvements to our existing New Jersey distribution center to improve capacity
and increase efficiency, and entered into an agreement to lease an inventory storage facility to provide a temporary overflow solution. Our overall goal is to leverage our existing distribution center as much as possible. However, we are also
looking at the possibility of establishing a second distribution center in the Western region of the United States in 2010. Management regularly reviews our anticipated requirements for all of our facilities and the costs and benefits associated
with new facilities and, based on that review, may adjust other of our facilities needs, as well.



|ITEM 3. | LEGAL PROCEEDINGS
|------- | -----------------

See Note 8 of our consolidated
financial statements, Commitments and ContingenciesLegal Proceedings, included in Part IV, Item 15 of this annual report.



|ITEM 4. | SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS
|------- | ---------------------------------------------------

No matters were submitted to a vote of our stockholders during the fourth quarter of fiscal year 2007.



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PART II



|ITEM 5. | MARKET FOR REGISTRANTS COMMON STOCK, RELATED STOCKHOLDER MATTERS, AND ISSUER PURCHASES OF EQUITY SECURITIES
|------- | ------------------------------------------------------------------------------------------------------------

Market Information

Our common stock is traded on the
NASDAQ Global Market under the symbol DSCM. The following table sets forth, for the periods indicated, the high and low sales prices of our common stock, as reported by the NASDAQ Global Market.



|                                    |  |      |      |     |   |     
|----------------------------------- |  | ---- | ---- | --- | - | ----
|                                    |  | High |      | Low
|Fiscal Year Ended December 30, 2007 |  |      |      |     |   |     
|First Quarter                       |  | $    | 3.83 |     | $ | 2.35
|Second Quarter                      |  | $    | 2.90 |     | $ | 2.40
|Third Quarter                       |  | $    | 3.26 |     | $ | 2.60
|Fourth Quarter                      |  | $    | 3.74 |     | $ | 2.90
|                                    |  |     
|                                    |  | High |      | Low
|Fiscal Year Ended December 31, 2006 |  |      |      |     |   |     
|First Quarter                       |  | $    | 3.31 |     | $ | 2.51
|Second Quarter                      |  | $    | 3.64 |     | $ | 2.65
|Third Quarter                       |  | $    | 3.71 |     | $ | 2.51
|Fourth Quarter                      |  | $    | 4.02 |     | $ | 3.23

Holders of Record

As of March 7, 2008, there were approximately 763 holders of record of our common stock, and a much larger number of beneficial owners.

Dividends

We have never declared or paid cash or stock dividends on our capital stock. We currently
intend to retain all available funds and any future earnings for use in the operation and expansion of our business and do not anticipate paying any dividends in the foreseeable future.



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Performance Graph

The graph below shows the relative investment performance of our common stock, the NASDAQ Stock Market Index and the Morgan Stanley High-Technology Index for the last five years. The following graph is presented
pursuant to SEC rules and is not meant to be an indication of our future performance.

LOGO



|                                 |  |            |     |            |   |          |  |          |        |            |   |            |  |   |        |  |   |       
|-------------------------------- |  | ---------- | --- | ---------- | - | -------- |  | -------- | ------ | ---------- | - | ---------- |  | - | ------ |  | - | ------
|                                 |  | 12/29/2002 |     | 12/28/2003 |   | 1/2/2005 |  | 1/1/2006 |        | 12/31/2006 |   | 12/30/2007
|Drugstore.com                    |  | $          | 100 |            | $ | 215.32   |  | $        | 144.68 |            | $ | 121.28     |  | $ | 155.74 |  | $ | 139.57
|NASDAQ Stock Market (U.S.) Index |  | $          | 100 |            | $ | 144.76   |  | $        | 159.60 |            | $ | 161.79     |  | $ | 177.20 |  | $ | 196.21
|Morgan Stanley High Tech Index   |  | $          | 100 |            | $ | 160.79   |  | $        | 174.19 |            | $ | 179.18     |  | $ | 194.96 |  | $ | 215.93

Recent Sales of Unregistered Securities

None.

Issuer Purchases of Equity Securities

None.



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|ITEM 6. | SELECTED FINANCIAL DATA
|------- | -----------------------



|                                                                                     |  |                                                 |            |   |      |   |            |      |  |   |            |   |  |      |            |   |  |   |            |  
|------------------------------------------------------------------------------------ |  | ----------------------------------------------- | ---------- | - | ---- | - | ---------- | ---- |  | - | ---------- | - |  | ---- | ---------- | - |  | - | ---------- | -
|                                                                                     |  | Fiscal Year                                     |           
|                                                                                     |  | 2007                                            |            |   | 2006 |   |            | 2005 |  |   | 2004       |   |  | 2003 |           
|                                                                                     |  | (in thousands, except share and per share data) |           
|Consolidated Statements of Operations Data:                                          |  |                                                 |            |   |      |   |            |      |  |   |            |   |  |      |            |   |  |   |            |  
|Net sales                                                                            |  | $                                               | 445,723    |   |      | $ | 415,777    |      |  | $ | 399,430    |   |  | $    | 360,099    |   |  | $ | 245,733    |  
|Loss before income taxes                                                             |  |                                                 | (11,511    | ) |      |   | (13,026    | )    |  |   | (20,899    | ) |  |      | (48,715    | ) |  |   | (18,649    | )
|Income tax benefit                                                                   |  |                                                 |           |   |      |   |           |      |  |   |           |   |  |      | 980        |   |  |   |           |  
|                                                                                     |  |                                                 |            |   |      |   |            |      |  |   |            |   |  |      |            |   |  |   |            |  
|Net loss(1)                                                                          |  | $                                               | (11,511    | ) |      | $ | (13,026    | )    |  | $ | (20,899    | ) |  | $    | (47,735    | ) |  | $ | (18,649    | )
|                                                                                     |  |                                                 |            |   |      |   |            |      |  |   |            |   |  |      |            |   |  |   |            |  
|Basic and diluted loss per share                                                     |  | $                                               | (0.12      | ) |      | $ | (0.14      | )    |  | $ | (0.23      | ) |  | $    | (0.62      | ) |  | $ | (0.27      | )
|                                                                                     |  |                                                 |            |   |      |   |            |      |  |   |            |   |  |      |            |   |  |   |            |  
|Weighted average shares outstanding used to compute basic and diluted loss per share |  |                                                 | 95,350,046 |   |      |   | 93,405,405 |      |  |   | 90,808,817 |   |  |      | 76,650,915 |   |  |   | 69,148,872 |  
|                                                                                     |  |                                                 |            |   |      |   |            |      |  |   |            |   |  |      |            |   |  |   |            |  
|                                                                                     |  |                                                 |            |   |     
|Consolidated Balance Sheet Data:                                                     |  |                                                 |            |   |      |   |            |      |  |   |            |   |  |      |            |   |  |   |            |  
|Cash, cash equivalents and marketable securities                                     |  | $                                               | 36,249     |   |      | $ | 40,639     |      |  | $ | 46,463     |   |  | $    | 34,219     |   |  | $ | 43,572     |  
|Cash dividends declared per common share                                             |  |                                                 |           |   |      |   |           |      |  |   |           |   |  |      |           |   |  |   |           |  
|Working capital                                                                      |  |                                                 | 34,195     |   |      |   | 37,451     |      |  |   | 40,350     |   |  |      | 27,719     |   |  |   | 32,043     |  
|Total assets                                                                         |  |                                                 | 175,408    |   |      |   | 168,322    |      |  |   | 170,563    |   |  |      | 158,511    |   |  |   | 184,412    |  
|Long-term debt obligations, less current portion                                     |  |                                                 | 1,221      |   |      |   | 1,839      |      |  |   | 2,685      |   |  |      | 1,807      |   |  |   | 600        |  
|Total stockholders equity                                                           |  | $                                               | 94,368     |   |      | $ | 92,678     |      |  | $ | 96,271     |   |  | $    | 87,128     |   |  | $ | 128,218    |  



|(1) | Includes impairment charges to long-lived assets of $27,460 in
2004.
|--- | --------------------------------------------------------------------



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##### Table of Contents

|ITEM 7. | MANAGEMENTS DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS
|------- | -------------------------------------------------------------------------------------

The following discussion should be read in conjunction with our consolidated financial statements and accompanying notes included in Part IV,
Item 15 of this annual report.

Overview

drugstore.com, inc. is a leading online provider of health, beauty, vision, and pharmacy products. We believe that we offer a better way for consumers to shop for these products through our web stores, including those located on the
Internet at www.drugstore.com, www.beauty.com, www.visiondirect.com, www.lensmart.com,andwww.lensquest.com.

We operate on
a 52/53-week retail calendar, with each quarter in a 52-week fiscal year representing a 13-week period. Fiscal years 2007, 2006, and 2005 were 52-week fiscal years. References in the following discussion to yearly periods are to fiscal years, unless
the context indicates otherwise. The year 2007 refers to the fiscal year ended December 30, 2007, year 2006 refers to the fiscal year ended December 31, 2006, and 2005 refers to the fiscal year ended
January 1, 2006.

Business Segments; Growth Strategies.We operate our business in four business
segments: OTC; vision; mail-order pharmacy; and local pick-up pharmacy.



| |  |  | Over-the-counter (OTC).    Our OTC segment includes all non-prescription products sold online through our web stores at
www.drugstore.com and www.beauty.com or over the telephone at 1-800-DRUGSTORE, including customized nutritional supplements sold through our subsidiary CNS. Before December 31, 2005, we recognized all sales of customized vitamins through
CNS on a gross basis, net of promotional discounts, cancellations, rebates, and returns allowances. On December 31, 2005, we entered into a fulfillment agreement with Weil. Under the terms of the new agreement, which replaced our previous
agreement with Weil, we recognize the revenue associated with the fulfillment of customized vitamins sold through Weil on a net basis. Until November 9, 2005, our OTC segment also included product revenues and fulfillment fees received under
our wholesale OTC fulfillment agreement with Amazon.com, Inc., under which we acted as a nonexclusive wholesaler and fulfillment provider for certain OTC products sold through the Health & Personal Care store on the Amazon.com website.
Effective November 9, 2005, we terminated this agreement. The change in the terms of our agreement with Weil, which led us to recognize revenue on a net basis for the substantial majority of our 2006 CNS revenue, and the termination of the
Amazon.com wholesale OTC agreement make it more difficult to provide a meaningful year-over-year comparison. Accordingly, in this annual report we refer to our core OTC net sales, which is a non-GAAP measure that excludes from OTC net
sales wholesale OTC net sales of $6.3 million for the year ended January 1, 2006 and CNS net sales of $1.9 million, $2.4 million and $8.0 million for the years ended December 30, 2007, December 31, 2006, and January 1, 2006,
respectively. Our management believes that the presentation of core OTC net sales and related information provides useful information to the company and its stockholders, because it excludes specific items that are no longer indicative of our core
operating results and facilitates a more meaningful comparison of year-over-year results of our OTC segment. We source our OTC products from various manufacturers and distributors, including drop-ship arrangements with vendors. We believe that
continued growth in this segment will depend on our ability to offer customers a superior shopping experience and service, including providing a broad selection of basic necessity items and hard-to-find specialty items, which encourages customers to
return to our websites and make repeat, replenishment, and impulse purchases. In 2008, we anticipate growth in our OTC segment, specifically our prestige beauty business, as we attract new brands and expand our marketing channels. We will also
continue our diversificationdriving our free search results and adding several new marketplaces and accelerating our margin improvements with targeted shipping, sourcing, and pricing initiatives.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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##### Table of Contents

| |  |  | Vision.    The vision segment includes contact lenses sold through our wholly owned subsidiary International Vision Direct Corp. and its
subsidiaries, collectively referred to as Vision Direct, through websites located at www.visiondirect.com, www.lensmart.com, and www.lensquest.com, or over the telephone at 1-800-VISIONDIRECT. We purchase our contact lens inventory
directly from various manufacturers and other distributors. In 2008, we anticipate single digit growth in our vision segment as we continue to focus on balancing customer acquisition with net margin in order to maximize our profits.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Mail-Order Pharmacy.    Our mail-order pharmacy segment includes prescription drugs and supplies, other than prescription contact lenses,
sold online through the pharmacy section of the drugstore.com web store or over the telephone and delivered to customers through our mail-order facility. We procure our prescription inventory through Rite Aid Corporation as part of our ongoing
relationship. We market to both cash-paying and insurance-covered individuals, and we also serve as a third-party provider of mail-order prescription fulfillment services for pharmacy benefit managers, or PBMs. We sell over 5,000 prescription drugs,
including many specialty drugs for the treatment of chronic conditions such as cancer, HIV, and multiple sclerosis, which are not carried by brick-and-mortar pharmacies and require special handling or service. In this segment, we focus our marketing
efforts directly on consumers online and through doctors to maximize growth in our cash prescription and specialty pharmacy business. In addition to the sale of prescription drugs, we sell advertising on our website, to monetize the more than one
million unique visitors per month researching drugs and other healthcare content provided on the site. We anticipate growth in our mail-order pharmacy segment in the second half of 2008 as we launch new marketing programs.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Local Pick-Up Pharmacy.    Our local pick-up pharmacy business segment includes prescription refills sold online through the
drugstore.com web store or the Rite Aid web store at www.RiteAid.com(which is powered by the drugstore.com web store) or over the telephone and picked up by customers at Rite Aid stores. In this segment, Rite Aid acts as our fulfillment
partner. Our success in this segment depends on our ability to leverage our relationship with Rite Aid through its marketing media, including Rite Aid store receipts, weekly Rite Aid advertising circulars, and e-mail refill reminders. In 2008, we
anticipate consistent year-over-year growth in net sales in the local pick-up pharmacy segment, as we focus the majority of our marketing efforts on our other segments.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Revenues.    We generate revenue primarily from product sales and shipping fees. In 2007, we reported consolidated total net
sales of $445.7 million, which reflected a $29.9 million, or 7%, increase over 2006. Our net sales growth was driven by a 10% year-over-year increase in our total order volume for 2007, to nearly 6.0 million orders. Our average net sales per
order declined slightly to $75 in 2007, from $77 in 2006. Our revenues benefited from strong growth in our OTC segment, in which net sales grew by 18% year-over-year. Our revenues in 2007 also benefited from year-over-year growth of 10% in our
vision segment and 6% in our local pick-up pharmacy segment. These increases were partially offset by a year-over-year decrease in mail-order pharmacy net sales of 26%.

Expenses.    Our operating expenses, including cost of goods sold, decreased as a percentage of net sales to 103% in 2007 compared to 104% in 2006. The decrease reflects both a favorable
shift in our product mix to higher margin OTC sales, as well as improvement in each of our business segments margins. This decrease was partially offset with an increase in our general and administrative expenses as a percentage of net sales
to 4.7% in 2007 compared to 3.7% in 2006, primarily as a result of a $2.5 million charge related to an estimate recorded for taxes and interest on an unfavorable ruling in the NJ sales tax case. As a percentage of net sales, our fulfillment,
marketing and sales, and technology and content expenses all remained relatively consistent year-over-year at 10%, 7%, and 4%, respectively.

Net Loss; Cash Position.    Our net loss for 2007 decreased by 12%, or $1.5 million, to $11.5 million, compared to $13.0 million for the year ended December 31, 2006. We ended 2007 with $36.2 million in cash,



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cash equivalents, and marketable securities, compared to $40.6 million at the end of 2006. This balance reflects cash provided by operations of $7.8 million
in 2007, proceeds of $4.4 million from the exercise of employee stock options and purchases under our employee stock purchase plan, and proceeds from debt borrowings of $4.0 million, offset by $14.7 million for capital expenditures, and $5.9 million
to repay debt obligations.

Results of Operations

Net Sales



|                              |  |                                       |         |          |      |   |                 |   |          |  |      |                 |  |   |        
|----------------------------- |  | ------------------------------------- | ------- | -------- | ---- | - | --------------- | - | -------- |  | ---- | --------------- |  | - | -------
|                              |  | Fiscal Year2007                       |         | % Change |      |   | Fiscal Year2006 |   | % Change |  |      | Fiscal Year2005
|                              |  | (in thousands, except per order data)
|Total net sales               |  | $                                     | 445,723 |          | 7.2  | % |                 | $ | 415,777  |  | 4.1  | %               |  | $ | 399,430
|Total customer orders shipped |  |                                       | 5,959   |          | 10.0 | % |                 |   | 5,416    |  | 5.8  | %               |  |   | 5,119  
|Average net sales per order   |  | $                                     | 75      |          | -2.6 | % |                 | $ | 77       |  | -1.6 | %               |  | $ | 78     

Net sales include gross revenues from sales of product and related shipping fees, net of discounts
and provision for sales returns, and other allowances. Net sales also include consignment service fees earned from our arrangement with GNC, under which we do not take title to the inventory and cannot establish pricing. Consignment service fees are
recorded on a net basis and constitute approximately 1% of total net sales in each period presented. Net sales in 2005 included fulfillment fees and product revenue from our wholesale OTC fulfillment agreement with Amazon.com, which we terminated in
November 2005. Also included in net sales in 2005, recorded on a gross basis, are sales of customized nutritional supplements sold through CNS, which, effective December 31, 2005, are now primarily recorded on a net basis under our fulfillment
agreement with Weil. Orders are billed to the customers credit card or, in the case of prescriptions covered by insurance, the co-payment is billed to the customers credit card and the remainder of the prescription price is billed to
insurance. Sales of pharmaceutical products covered by insurance are recorded as the sum of the amounts received from the customer and the third party. Sales made to Amazon.com under our terminated wholesale OTC fulfillment agreement were billed
directly to Amazon.com and recorded at the gross amount received from Amazon.com.

Total net sales increased in 2007 compared to the prior
year, primarily as a result of a 10% increase in order volume, to 6.0 million orders from 5.4 million in 2006, and were partially offset with a 3% decrease in the average net revenue per order, to $75. The order growth was primarily driven
by growth in our OTC segment, and to a lesser extent, in our local-pick up segment. Our average net revenue per order decreased in our mail-order pharmacy segment, partially offset by an increase in our average net revenue per order in our OTC
segment and vision segment in 2007. Total net sales increased in 2006 compared to the prior year, primarily as a result of a 6% increase in order volume, to 5.4 million orders from 5.1 million in 2005, and were partially offset with a 2%
decrease in the average net revenue per order, to $77. The order growth was primarily driven by growth in our OTC segment, and to a lesser extent, in our local-pick up segment. Our average net revenue per order decreased in our OTC segment and
local-pick up segments in 2006, offset by growth in our average net revenue per order in our mail-order pharmacy and vision segments. Revenues from repeat customers remained flat at 82% of total net sales in 2007 and 2006, and increased from 79% in
2005.

OTC Net Sales



|                                 |  |                                       |         |   |          |      |   |                 |   |         |          |  |      |                 |  |   |         |  
|-------------------------------- |  | ------------------------------------- | ------- | - | -------- | ---- | - | --------------- | - | ------- | -------- |  | ---- | --------------- |  | - | ------- | -
|                                 |  | Fiscal Year2007                       |         |   | % Change |      |   | Fiscal Year2006 |   |         | % Change |  |      | Fiscal Year2005 | 
|                                 |  | (in thousands, except per order data) |        
|OTC net sales                    |  | $                                     | 234,282 |   |          | 18.3 | % |                 | $ | 197,964 |          |  | 9.6  | %               |  | $ | 180,566 |  
|Segmented net sales information: |  |                                       |         |   |          |      |   |                 |   |         |          |  |      |                 |  |   |         |  
|% of total net sales from OTC    |  |                                       | 52.6    | % |          |      |   |                 |   | 47.6    | %        |  |      |                 |  |   | 45.2    | %
|Average net sales per order      |  | $                                     | 57      |   |          | 1.9  | % |                 | $ | 56      |          |  | -1.5 | %               |  | $ | 57      |  



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Net sales in our OTC segment increased in 2007 compared to the prior year, as a result of an increase in
order volume and average net sales per order. The number of orders in our OTC segment grew year-over-year by 16% to 4.1 million in 2007, compared to 3.5 million in 2006. Our core OTC net sales, which exclude CNS net sales of $1.9 million
in 2007, increased by 19% to $232.4 million in 2007 compared to $195.6 million in 2006. The number of orders in our core OTC segment grew by 17% to 4.0 million in 2007 compared to just under 3.5 million in 2006. Average net sales per order
for our OTC segment increased to $57 in 2007 compared to $56 in 2006 and average net sales per order for our core OTC segment increased to $58 in 2007 compared to $57 in 2006. The increase in OTC order volumes in 2007 compared to 2006 was driven by
increased orders from both new and repeat customers as a result of our increasing active customer base and our continued efforts to improve customer retention and conversion resulting from our ongoing website enhancements and expanding our product
offerings through our arrangements with drop-ship vendors. The slight year-over-year increase in average net sales per order for 2007 is primarily the result of increased sales of higher priced prestige beauty products, and to a lesser extent, a
decrease in discounts and promotional offers.

Net sales in our OTC segment increased in 2006 compared to the prior year as a result of an
increase in order volume. The number of orders in our OTC segment grew year-over-year by 12% to 3.5 million in 2006, compared to 3.2 million in 2005. Our core OTC net sales, which excludes CNS net sales of $2.4 million in 2006 and $8.0
million in 2005, and wholesale OTC net sales and fulfillment fees of $6.3 million in 2005, increased by 18% to $195.6 million in 2006 compared to $166.2 million in 2005. The number of orders in our core OTC segment grew by 21% to just under
3.5 million in 2006 compared to 2.8 million in 2005. Average net sales per order for our OTC segment decreased to $56 in 2006 compared to $57 in 2005 and average net sales per order for our core OTC segment decreased to $57 in 2006
compared to $58 in 2005, as a result of our profitability initiatives related to shipping and our efforts to maintain competitive pricing, which reduced our average number of units per order.

Vision Net Sales



|                                 |  |                                       |        |   |          |      |   |                 |   |        |          |  |     |                 |  |   |        |  
|-------------------------------- |  | ------------------------------------- | ------ | - | -------- | ---- | - | --------------- | - | ------ | -------- |  | --- | --------------- |  | - | ------ | -
|                                 |  | Fiscal Year2007                       |        |   | % Change |      |   | Fiscal Year2006 |   |        | % Change |  |     | Fiscal Year2005 | 
|                                 |  | (in thousands, except per order data) |       
|Vision net sales                 |  | $                                     | 54,906 |   |          | 10.3 | % |                 | $ | 49,780 |          |  | 5.6 | %               |  | $ | 47,126 |  
|Segmented net sales information: |  |                                       |        |   |          |      |   |                 |   |        |          |  |     |                 |  |   |        |  
|% of total net sales from vision |  |                                       | 12.3   | % |          |      |   |                 |   | 12.0   | %        |  |     |                 |  |   | 11.8   | %
|Average net sales per order      |  | $                                     | 99     |   |          | 9.8  | % |                 | $ | 90     |          |  | 9.9 | %               |  | $ | 82     |  

Net sales in our vision segment increased in 2007 and 2006 compared to the prior year, as a result
of an increase in average net sales per order driven primarily by selling a greater proportion of higher-priced, newer-technology contact lenses, and to a lesser extent, an increase in the average number of items per order, price increases for
certain products (none of which were individually material), and increased per order shipping revenue. These increases were partially offset by increased discount and promotional offers. The number of orders in this segment remained relatively flat
at 553,000 in 2007 compared to 551,000 in 2006. The number of orders in this segment decreased to 551,000 in 2006 compared to 572,000 in 2005, as a result of decreased new customer orders.

Mail-Order Pharmacy Net Sales



|                                              |  |                                       |        |   |          |       |   |                 |   |        |          |  |       |                 |  |   |        |  
|--------------------------------------------- |  | ------------------------------------- | ------ | - | -------- | ----- | - | --------------- | - | ------ | -------- |  | ----- | --------------- |  | - | ------ | -
|                                              |  | Fiscal Year2007                       |        |   | % Change |       |   | Fiscal Year2006 |   |        | % Change |  |       | Fiscal Year2005 | 
|                                              |  | (in thousands, except per order data) |       
|Mail-order pharmacy net sales                 |  | $                                     | 50,143 |   |          | -25.6 | % |                 | $ | 67,379 |          |  | -10.9 | %               |  | $ | 75,612 |  
|Segmented net sales information:              |  |                                       |        |   |          |       |   |                 |   |        |          |  |       |                 |  |   |        |  
|% of total net sales from mail-order pharmacy |  |                                       | 11.2   | % |          |       |   |                 |   | 16.2   | %        |  |       |                 |  |   | 18.9   | %
|Average net sales per order                   |  | $                                     | 159    |   |          | -3.0  | % |                 | $ | 164    |          |  | 12.0  | %               |  | $ | 147    |  



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Net sales in our mail-order pharmacy segment decreased in 2007 compared to the prior year, as a result of
decreases in order volume and average net sales per order. Included in net sales of our mail-order pharmacy segment in 2007 were wholesale orders to two parties totaling $2.4 million, which increased our average net sales per order by $8 in 2007,
and included in net sales in 2006 were wholesale orders to one party totaling $3.5 million, which increased our average net sales per order by $9 in 2006. The number of orders in this segment decreased 23% to 315,000 in 2007 compared to 411,000 in
2006. The 2007 decrease reflects a 46% decrease in orders from PBMs, due to our decision to exit unprofitable partnerships, and a 19% decrease in orders from both new and repeat customers. Excluding the wholesale orders, average net sales per order
decreased by $4 in this segment in 2007 compared to the prior year, as a result of a decrease in orders from PBMs which have higher net revenues per order but lower per order net margins.

Net sales in our mail-order pharmacy segment decreased in 2006 compared to the prior year, as a result of decreases in order volume, partially offset by
increases in average net sales per order. Included in net sales of our mail-order pharmacy segment in 2006 were wholesale orders to one party totaling $3.5 million, which increased our average net sales per order by $9 in 2006. In addition to the
wholesale orders, average net sales per order increased $8 in this segment in 2006 compared to the prior year, as a result of selling a larger proportion of higher-priced brand-name and specialty drugs, increases in prescription prices of
approximately 5% resulting primarily from brand-name product inflation, and pricing adjustments to certain products resulting from our review of the pricing and profitability of our pharmaceutical products. The number of orders in this segment
decreased 20% to 411,000 in 2006 compared to 515,000 in 2005. These decreases reflected a 23% decrease in orders from PBM partnerships, primarily due to our decision to exit unprofitable PBM partnerships, and a 19% decrease in orders from customers,
both new and repeat, primarily due to our decision not to participate in the low-margin Medicare Part D prescription drug benefit program offered by the U.S. government.

Local Pick-up Pharmacy Net Sales



|                                                 |  |                                       |         |   |          |     |   |                 |   |         |          |  |      |                 |  |   |        |  
|------------------------------------------------ |  | ------------------------------------- | ------- | - | -------- | --- | - | --------------- | - | ------- | -------- |  | ---- | --------------- |  | - | ------ | -
|                                                 |  | Fiscal Year2007                       |         |   | % Change |     |   | Fiscal Year2006 |   |         | % Change |  |      | Fiscal Year2005 | 
|                                                 |  | (in thousands, except per order data) |        
|Local pick-up pharmacy net sales                 |  | $                                     | 106,392 |   |          | 5.7 | % |                 | $ | 100,654 |          |  | 4.7  | %               |  | $ | 96,126 |  
|Segmented net sales information:                 |  |                                       |         |   |          |     |   |                 |   |         |          |  |      |                 |  |   |        |  
|% of total net sales from local pick-up pharmacy |  |                                       | 23.9    | % |          |     |   |                 |   | 24.2    | %        |  |      |                 |  |   | 24.1   | %
|Average net sales per order                      |  | $                                     | 106     |   |          |    |   |                 | $ | 106     |          |  | -2.8 | %               |  | $ | 109    |  

Net sales in our local pick-up pharmacy segment increased in 2007 compared to the prior year, as a
result of an increase in order volume. The number of orders in this segment increased to 1.0 million in 2007 compared to 948,000 in 2006, as a result of increased repeat customer orders. Average net sales per order in our local-pick up pharmacy
segment remained flat at $106 in 2007 and 2006.

Net sales in our local pick-up pharmacy segment increased in 2006 compared to the prior
year, as a result of an increase in order volume, partially offset by decreases in average net sales per order. The number of orders in this segment increased to 948,000 in 2006 compared to 880,000 in 2005, as a result of increased repeat customer
orders. The decrease in average net sales per order resulted primarily from a 5% decline year-over-year in the average number of prescriptions filled per order and a lower number of higher-priced brand-name prescriptions filled compared to
lower-priced generic prescriptions filled.

Rite Aid drives orders in this segment through its marketing media, including Rite Aid store
receipts, weekly Rite Aid advertising circulars, and e-mail refill reminders.



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Customer Data

Approximately 1.4 million new customer orders were shipped during 2007, increasing our total customer base to nearly 10.0 million customers since inception. Orders from repeat customers as a percentage of
total orders remained consistent year-over-year at 75% for 2007 and 2006, and increased over 2005 from 72%. The increases in orders from repeat customers as a percentage of total orders in 2007 and 2006 compared to 2005, resulted primarily from
improved customer retention and increased order frequency. In addition, to a lesser extent, this increase reflects the inclusion of 352,000 wholesale OTC orders in total orders for 2005, compared to no such orders in 2006 or 2007. OTC wholesale
orders and Weil-related orders (after December 31, 2005) are included in the number of total orders but are considered neither repeat nor new orders for calculating repeat orders as a percentage of total orders.

Cost of Sales and Gross Margin



|                        |  |                  |         |   |          |      |   |                 |   |         |          |  |     |                 |  |   |         |  
|----------------------- |  | ---------------- | ------- | - | -------- | ---- | - | --------------- | - | ------- | -------- |  | --- | --------------- |  | - | ------- | -
|                        |  | Fiscal Year2007  |         |   | % Change |      |   | Fiscal Year2006 |   |         | % Change |  |     | Fiscal Year2005 | 
|                        |  | ($ in thousands) |        
|Cost of sales           |  | $                | 341,919 |   |          | 4.9  | % |                 | $ | 326,036 |          |  | 2.7 | %               |  | $ | 317,366 |  
|Gross profit dollars    |  | $                | 103,804 |   |          | 15.7 | % |                 | $ | 89,741  |          |  | 9.4 | %               |  | $ | 82,064  |  
|Gross margin percentage |  |                  | 23.3    | % |          |      |   |                 |   | 21.6    | %        |  |     |                 |  |   | 20.5    | %

Cost of sales consists primarily of the cost of products sold to our customers, including
allowances for shrinkage and damaged, slow-moving and expired inventory, outbound and inbound shipping costs, and expenses related to promotional inventory included in shipments to customers. Payments that we receive from vendors in connection with
volume purchase or rebate allowances and payment discount terms are netted against cost of sales.

Total cost of sales increased in
absolute dollars in 2007 and 2006 compared to the prior year, as a result of growth in order volume and net sales. Gross margin percentage increased in 2007 compared to the prior year, as a result of a larger proportion of net sales in our OTC
segment, which is our highest-margin segment, and improved gross margin percentages in all of our business segments in 2007. Gross margin percentage increased in 2006 compared to the prior year, as a result of lower net shipping loss, a larger
proportion of net sales in our OTC segment, and improved margins resulting from our operational initiatives, including the review of pricing and profitability of our OTC products.

Shipping



|                         |  |                  |          |   |          |      |   |                 |   |          |          |  |       |                 |  |   |          |  
|------------------------ |  | ---------------- | -------- | - | -------- | ---- | - | --------------- | - | -------- | -------- |  | ----- | --------------- |  | - | -------- | -
|                         |  | Fiscal Year2007  |          |   | % Change |      |   | Fiscal Year2006 |   |          | % Change |  |       | Fiscal Year2005 | 
|                         |  | ($ in thousands) |         
|Shipping activity:       |  |                  |          |   |          |      |   |                 |   |          |          |  |       |                 |  |   |          |  
|Shipping revenue         |  | $                | 15,403   |   |          | 13.1 | % |                 | $ | 13,618   |          |  | 22.4  | %               |  | $ | 11,129   |  
|Shipping costs           |  |                  | ($24,802 | ) |          | 13.2 | % |                 |   | ($21,905 | )        |  | 2.2   | %               |  |   | ($21,432 | )
|                         |  |                  |          |   |          |      |   |                 |   |          |          |  |       |                 |  |   |          |  
|Net shipping loss        |  |                  | ($9,399  | ) |          | 13.4 | % |                 |   | ($8,287  | )        |  | -19.6 | %               |  |   | ($10,303 | )
|                         |  |                  |          |   |          |      |   |                 |   |          |          |  |       |                 |  |   |          |  
|Percentage of net sales: |  |                  |          |   |          |      |   |                 |   |          |          |  |       |                 |  |   |          |  
|Shipping revenue         |  |                  | 3.5      | % |          |      |   |                 |   | 3.3      | %        |  |       |                 |  |   | 2.8      | %
|Shipping costs           |  |                  | -5.6     | % |          |      |   |                 |   | -5.3     | %        |  |       |                 |  |   | -5.4     | %
|Net shipping loss        |  |                  | -2.1     | % |          |      |   |                 |   | -2.0     | %        |  |       |                 |  |   | -2.6     | %

Our net shipping loss increased in absolute dollars and as a percentage of net sales in 2007
compared to the prior year, as a result of a higher mix of OTC orders, which have a higher net shipping loss than orders in our other business segments. In late 2007, we renegotiated lower contractual rates from our largest shipping carrier,



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which we anticipate will have a favorable impact on our net shipping loss in 2008. Our net shipping loss decreased in absolute dollars and as a percentage of
net sales in 2006 compared to the prior year, as a result of our profitability initiatives in 2006, which eliminated free 3-day shipping on orders of $99 or more, added shipping surcharges for shipments to Alaska, Hawaii, U.S. Territories, and
APO/FPO military addresses, added a weight-based shipping surcharge for orders over 20 pounds, and secured a lower contractual rate from one of our shipping carriers. We include in net sales our revenues from shipping charges to customers and we
include in cost of sales outbound shipping costs. We expect to continue to subsidize a portion of customers shipping costs for the foreseeable future, through certain free shipping options, as a strategy to attract and retain customers.

OTC Cost of Sales and Gross Margin



|                                     |  |                  |         |   |          |      |   |                 |   |         |          |  |     |                 |  |   |         |  
|------------------------------------ |  | ---------------- | ------- | - | -------- | ---- | - | --------------- | - | ------- | -------- |  | --- | --------------- |  | - | ------- | -
|                                     |  | Fiscal Year2007  |         |   | % Change |      |   | Fiscal Year2006 |   |         | % Change |  |     | Fiscal Year2005 | 
|                                     |  | ($ in thousands) |        
|OTC cost of sales                    |  | $                | 164,469 |   |          | 17.8 | % |                 | $ | 139,674 |          |  | 7.2 | %               |  | $ | 130,346 |  
|Segmented cost of sales information: |  |                  |         |   |          |      |   |                 |   |         |          |  |     |                 |  |   |         |  
|OTC gross profit dollars             |  | $                | 69,813  |   |          |      |   |                 | $ | 58,290  |          |  |     |                 |  | $ | 50,220  |  
|OTC gross margin percentage          |  |                  | 29.8    | % |          |      |   |                 |   | 29.4    | %        |  |     |                 |  |   | 27.8    | %

Cost of sales in our OTC segment increased in absolute dollars in 2007 and 2006 compared to the
prior year, as a result of growth in order volume and net sales. Gross margin percentage increased in 2007 compared to the prior year, primarily as a result of a shift in product mix to higher margin prestige beauty products, increased vendor
promotion and advertising dollars, and a decrease in discounts and promotional offers. Gross margin percentage increased in 2006 compared to the prior year, primarily as a result of improved margins resulting from our OTC profitability initiatives,
and lower per-order net shipping costs resulting from revisions to our shipping policies.

Vision Cost of Sales and Gross Margin



|                                     |  |                  |        |   |          |     |   |                 |   |        |          |  |     |                 |  |   |        |  
|------------------------------------ |  | ---------------- | ------ | - | -------- | --- | - | --------------- | - | ------ | -------- |  | --- | --------------- |  | - | ------ | -
|                                     |  | Fiscal Year2007  |        |   | % Change |     |   | Fiscal Year2006 |   |        | % Change |  |     | Fiscal Year2005 | 
|                                     |  | ($ in thousands) |       
|Cost of sales                        |  | $                | 41,904 |   |          | 8.3 | % |                 | $ | 38,682 |          |  | 4.5 | %               |  | $ | 37,008 |  
|Segmented cost of sales information: |  |                  |        |   |          |     |   |                 |   |        |          |  |     |                 |  |   |        |  
|Vision gross profit dollars          |  | $                | 13,002 |   |          |     |   |                 | $ | 11,098 |          |  |     |                 |  | $ | 10,118 |  
|Vision gross margin percentage       |  |                  | 23.7   | % |          |     |   |                 |   | 22.3   | %        |  |     |                 |  |   | 21.5   | %

Cost of sales in our vision segment increased in absolute dollars in 2007 compared to the prior
year, primarily as a result of a shift in product mix to sales of higher cost, newer-technology contact lenses, while order volume remained relatively flat. Gross margin percentage in this segment increased in 2007 compared to the prior year, as a
result of a shift in product mix to higher margin contact lenses, and to a lesser extent, increased prices on certain products, offset by increased discount and promotional offers.

Cost of sales in our vision segment increased in absolute dollars in 2006 compared to the prior year, primarily as a result of a shift in product mix to
sales of higher cost, newer-technology contact lenses, partially offset by a decline in order volume. Gross margin percentage in this segment increased in 2006 compared to the prior year, as a result of a shift in product mix to higher margin
contact lenses, lower per-order shipping costs, and to a lesser extent, increased prices on certain products, offset by increased discount and promotional offers.



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Mail-Order Pharmacy Cost of Sales and Gross Margin



|                                            |  |                  |        |   |          |       |   |                 |   |        |          |  |       |                 |  |   |        |  
|------------------------------------------- |  | ---------------- | ------ | - | -------- | ----- | - | --------------- | - | ------ | -------- |  | ----- | --------------- |  | - | ------ | -
|                                            |  | Fiscal Year2007  |        |   | % Change |       |   | Fiscal Year2006 |   |        | % Change |  |       | Fiscal Year2005 | 
|                                            |  | ($ in thousands) |       
|Cost of sales                               |  | $                | 41,935 |   |          | -27.7 | % |                 | $ | 58,026 |          |  | -11.2 | %               |  | $ | 65,352 |  
|Segmented cost of sales information:        |  |                  |        |   |          |       |   |                 |   |        |          |  |       |                 |  |   |        |  
|Mail-order pharmacy gross profit dollars    |  | $                | 8,208  |   |          |       |   |                 | $ | 9,353  |          |  |       |                 |  | $ | 10,260 |  
|Mail-order pharmacy gross margin percentage |  |                  | 16.4   | % |          |       |   |                 |   | 13.9   | %        |  |       |                 |  |   | 13.6   | %

Cost of sales in our mail-order pharmacy segment decreased in absolute dollars in 2007 and 2006
compared to the prior years, as a result of a decrease in order volume and net sales. Gross margin percentage increased in this segment in 2007 and 2006 compared to the prior years, as a result of improved margins from exiting unprofitable
partnerships with certain PBMs in 2006 and our ongoing review of pricing and profitability of pharmaceutical products.

Local Pick-up
Pharmacy Cost of Sales and Gross Margin



|                                       |  |                  |        |   |          |     |   |                 |   |        |          |  |     |                 |  |   |        |  
|-------------------------------------- |  | ---------------- | ------ | - | -------- | --- | - | --------------- | - | ------ | -------- |  | --- | --------------- |  | - | ------ | -
|                                       |  | Fiscal Year2007  |        |   | % Change |     |   | Fiscal Year2006 |   |        | % Change |  |     | Fiscal Year2005 | 
|                                       |  | ($ in thousands) |       
|Cost of sales                          |  | $                | 93,611 |   |          | 4.4 | % |                 | $ | 89,654 |          |  | 5.9 | %               |  | $ | 84,660 |  
|Segmented cost of sales information:   |  |                  |        |   |          |     |   |                 |   |        |          |  |     |                 |  |   |        |  
|Local pick-up gross profit dollars     |  | $                | 12,781 |   |          |     |   |                 | $ | 11,000 |          |  |     |                 |  | $ | 11,466 |  
|Local pick-up gross margin percentages |  |                  | 12.0   | % |          |     |   |                 |   | 10.9   | %        |  |     |                 |  |   | 11.9   | %

Cost of sales in our local pick-up pharmacy segment increased in absolute dollars in 2007 and 2006
compared to the prior year, as a result of an increase in order volume and net sales. Gross margin percentage increased in this segment in 2007 compared to the prior year, as a result of selling a higher proportion of higher margin generic drugs
compared to lower margin brand name drugs. Gross margin decreased in this segment in 2006 compared to the prior year, as a result of lower contractual reimbursement rates from insurance plans and declining margins on generic drugs.

Fulfillment and Order Processing Expense



|                                         |  |                  |        |   |          |     |   |                 |   |        |          |  |      |                 |  |   |        |  
|---------------------------------------- |  | ---------------- | ------ | - | -------- | --- | - | --------------- | - | ------ | -------- |  | ---- | --------------- |  | - | ------ | -
|                                         |  | Fiscal Year2007  |        |   | % Change |     |   | Fiscal Year2006 |   |        | % Change |  |      | Fiscal Year2005 | 
|                                         |  | ($ in thousands) |       
|Fulfillment and order processing expense |  | $                | 44,200 |   |          | 7.5 | % |                 | $ | 41,099 |          |  | 3.1  | %               |  | $ | 39,855 |  
|Percentage of net sales                  |  |                  | 9.9    | % |          |     |   |                 |   | 9.9    | %        |  |      |                 |  |   | 10.0   | %
|Fixed and variable cost information:     |  |                  |        |   |          |     |   |                 |   |        |          |  |      |                 |  |   |        |  
|Variable costs                           |  | $                | 33,212 |   |          | 8.2 | % |                 | $ | 30,695 |          |  | 0.8  | %               |  | $ | 30,464 |  
|Fixed costs                              |  | $                | 10,988 |   |          | 5.6 | % |                 | $ | 10,404 |          |  | 10.8 | %               |  | $ | 9,391  |  

Fulfillment and order processing expenses include payroll and related expenses for personnel
engaged in purchasing, fulfillment, distribution, and customer care activities (including warehouse personnel and pharmacists engaged in prescription verification activities), distribution center equipment and packaging supplies, per-unit
fulfillment fees charged by Rite Aid for prescriptions ordered through the drugstore.com website and picked up at a Rite Aid store, drop-ship processing fees, credit card processing fees, and bad debt expenses. These expenses also include rent and
depreciation related to equipment and fixtures in our distribution center and call center facilities. Variable fulfillment costs represent the incremental (variable) costs of fulfilling, processing, and delivering the order that are variable based
on sales volume.



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Variable fulfillment and order processing expenses increased by $2.5 million in 2007 compared to the
prior year, primarily as a result of a 16% increase in order volume in our OTC segment, partially offset by a 23% decrease in order volume in our mail-order pharmacy segment. Fixed fulfillment and order processing expenses increased in 2007 compared
to the prior year, primarily as a result of increased depreciation expense of $350,000 related to improvements made to our primary distribution center, and increased personnel costs of $204,000 resulting primarily from an increase in headcount.
Fulfillment and order processing expenses as a percentage of net sales remained flat in 2007 compared to 2006.

Variable fulfillment and
order processing expenses remained flat in 2006 compared to 2005 primarily as a result of a 12% increase in order volume in our OTC segment, offset by a 20% decrease in order volume in our mail-order pharmacy segment. Fixed fulfillment and order
processing expenses increased in 2006 compared to 2005 primarily as a result of increased personnel costs of $1.0 million and increased stock-based compensation expense of $833,000 resulting from the adoption of FAS 123(R), partially offset by a
decrease of $812,000 in depreciation expense. Fulfillment and order processing expenses as a percentage of net sales decreased slightly in 2006 compared to 2005, as greater order volumes resulted in improved utilization of our primary distribution
center.

Marketing and Sales Expense



|                            |  |                  |   |  |          |  |                 |   |  |          |  |                 |  
|--------------------------- |  | ---------------- | - |  | -------- |  | --------------- | - |  | -------- |  | --------------- | -
|                            |  | Fiscal Year2007  |   |  | % Change |  | Fiscal Year2006 |   |  | % Change |  | Fiscal Year2005 |  
|                            |  | ($ in thousands) |  
|Marketing and sales expense |  | $32,370          |   |  | 8.9%     |  | $29,735         |   |  | -9.4%    |  | $32,810         |  
|Percentage of net sales     |  | 7.3              | % |  |          |  | 7.2             | % |  |          |  | 8.2             | %

Marketing and sales expenses include advertising expenses, promotional expenditures and payroll
and related expenses for personnel engaged in marketing and merchandising activities. Advertising expenses include our obligations under various advertising contracts. In addition, marketing and sales expense include CNS-related royalties of
$105,000 in 2007, $62,000 in 2006, and $2.5 million in 2005, which decreased in 2006 as a result of our fulfillment agreement that we entered into on December 31, 2005 with Weil. Advertising and promotional costs were $23.0 million in 2007,
$21.0 million in 2006, and $25.6 million in 2005.

Marketing and sales expenses increased in absolute dollars but remained consistent as a
percentage of net sales in 2007 compared to the prior year. The increase in absolute dollars was primarily due to an increase of $4.0 million in search and portal costs, an increase in personnel expenses of $466,000, primarily due to increased
stock-based compensation, an increase in professional fees of $160,000, partially offset by a reduction of costs of $2.0 million related to our brand awareness campaign, which we concluded in the first quarter of 2006.

Marketing and sales expenses decreased both in absolute dollars and as a percentage of net sales in 2006 compared to the prior year. These decreases were
primarily due to a decrease of $3.5 million in expenses related to print and online advertising in connection with our brand awareness campaign, which we concluded in the first quarter of 2006, and a decrease in CNS royalties of $2.4 million. These
decreases were partially offset by an increase in advertising and promotional expenses of $1.3 million, increased professional fees of $675,000, and increased stock-based compensation expense of $840,000 resulting from the adoption of FAS 123(R).

Marketing and sales expense per new customer decreased in 2007 to $23 compared to $24 in 2006 and decreased from $27 in 2005, primarily as
a result of the conclusion of our brand awareness campaign in the first quarter of 2006.



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Technology and Content Expense



|                               |  |                  |   |  |          |  |                 |   |  |          |  |                 |  
|------------------------------ |  | ---------------- | - |  | -------- |  | --------------- | - |  | -------- |  | --------------- | -
|                               |  | Fiscal Year2007  |   |  | % Change |  | Fiscal Year2006 |   |  | % Change |  | Fiscal Year2005 |  
|                               |  | ($ in thousands) |  
|Technology and content expense |  | $18,258          |   |  | 12.8%    |  | $16,190         |   |  | 26.8%    |  | $12,773         |  
|Percentage of net sales        |  | 4.1              | % |  |          |  | 3.9             | % |  |          |  | 3.2             | %

Technology and content expenses consist primarily of payroll and related expenses for personnel
engaged in developing, maintaining, and making routine upgrades and enhancements to our websites. Technology and content expenses also include Internet access and hosting charges, depreciation on hardware and IT structures, utilities, and website
content and design expenses.

Technology and content expenses increased both in absolute dollars and as a percentage of net sales in 2007
compared to the prior year. The increase was primarily due to increases in depreciation costs of $1.1 million and increases in software license and maintenance costs of $675,000, resulting from the completion of internally developed software
projects and the acquisition of software and computer equipment to enhance our websites and IT infrastructure, and to a lesser extent, an increase of $152,000 of stock-based compensation expense.

Technology and content expenses increased both in absolute dollars and as a percentage of net sales in 2006 compared to the prior year. The increase was
primarily due to an increase in depreciation costs of $1.6 million resulting from the acquisition of software and computer equipment related to enhancements to our IT infrastructure, an increase of $1.1 million in stock-based compensation expense
resulting from the adoption of FAS 123(R), and increased operational costs of $1.4 million to support growth in our IT infrastructure. These increases were offset by the write-off of internally developed software projects in 2005.

General and Administrative Expense



|                                   |  |                  |        |   |          |      |   |                 |   |        |          |  |      |                 |  |   |        |  
|---------------------------------- |  | ---------------- | ------ | - | -------- | ---- | - | --------------- | - | ------ | -------- |  | ---- | --------------- |  | - | ------ | -
|                                   |  | Fiscal Year2007  |        |   | % Change |      |   | Fiscal Year2006 |   |        | % Change |  |      | Fiscal Year2005 | 
|                                   |  |                  |        |  
|                                   |  | ($ in thousands) |       
|General and administrative expense |  | $                | 20,928 |   |          | 35.8 | % |                 | $ | 15,413 |          |  | -2.4 | %               |  | $ | 15,791 |  
|Percentage of net sales            |  |                  | 4.7    | % |          |      |   |                 |   | 3.7    | %        |  |      |                 |  |   | 4.0    | %

General and administrative expenses consist of payroll and related expenses for executive and
administrative personnel, corporate facility expenses, professional service expenses, and other general corporate expenses.

General and
administrative expenses increased in both absolute dollars and as a percentage of net sales in 2007 compared to the prior year. The increases in 2007 were primarily due to a $2.5 million expense related to an estimate recorded for taxes and interest
on an unfavorable ruling on our NJ sales tax case, an increase in professional fees of $1.2 million, related to a consulting project focused on our profitability initiatives, and an increase in stock-based compensation of $1.7 million, resulting
from the issuance of warrants for services totaling $529,000 and the amortization of stock-based compensation under FAS 123(R).

General
and administrative expenses decreased in both absolute dollars and as a percentage of net sales in 2006 compared to the prior year. The decrease was primarily due to a reduction in professional fees in 2006 as a result of reduced external legal
fees, reduced corporate insurance, and the absence of expenses incurred in 2005 related to legal settlements and moving expenses related to the relocation of our corporate headquarters, as well as the fact that our fixed corporate administrative
costs were spread over more net sales. These decreases were offset by an increase in stock-based compensation expense of $2.0 million resulting from the adoption of FAS 123(R) and increased personnel expenses.



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Amortization of Intangible Assets



|                                  |  |                  |       |   |          |       |   |                 |   |       |          |  |       |                 |  |   |       |  
|--------------------------------- |  | ---------------- | ----- | - | -------- | ----- | - | --------------- | - | ----- | -------- |  | ----- | --------------- |  | - | ----- | -
|                                  |  | Fiscal Year2007  |       |   | % Change |       |   | Fiscal Year2006 |   |       | % Change |  |       | Fiscal Year2005 | 
|                                  |  | ($ in thousands) |      
|Amortization of intangible assets |  | $                | 1,234 |   |          | -40.1 | % |                 | $ | 2,060 |          |  | -31.4 | %               |  | $ | 3,004 |  
|Percentage of net sales           |  |                  | 0.3   | % |          |       |   |                 |   | 0.5   | %        |  |       |                 |  |   | 0.8   | %

Amortization of intangible assets includes
the amortization expense associated with assets acquired in connection with our acquisitions of CNS and Acumins, Inc., and assets acquired in connection with our agreements with Rite Aid and GNC, and other intangible assets, including a technology
license agreement, domain names, and trademarks. In the third quarter of 2007, we acquired for $456,000 certain trademarks and intangibles associated with our new, private label de-luxeTMbrand of natural, spa quality personal care products.

Amortization
expense decreased in 2007 and 2006 compared to the prior year, as a result of certain intangible assets being fully amortized in 2007, 2006, and 2005.

Interest Income and Expense



|                     |  |                  |  |          |  |                 |  |          |  |                
|-------------------- |  | ---------------- |  | -------- |  | --------------- |  | -------- |  | ---------------
|                     |  | Fiscal Year2007  |  | % Change |  | Fiscal Year2006 |  | % Change |  | Fiscal Year2005
|                     |  | ($ in thousands)
|Interest income, net |  | $1,675           |  | -3.2%    |  | $1,730          |  | 36.2%    |  | $1,270         

Interest income consists of earnings on our cash, cash equivalents, and marketable securities, and
interest expense consists primarily of interest associated with capital lease and debt obligations. Net interest income has remained consistent in 2007 compared to 2006, and net interest income increased in 2006 compared to 2005, as a result of
receiving higher returns on cash, cash equivalents, and marketable securities balances in 2006 compared to the same period in 2005, despite a decrease in our cash, cash equivalents, and marketable securities balance.

Significant Accounting Judgments

The preparation of
financial statements in conformity with U.S. generally accepted accounting principles, or GAAP, requires estimates and assumptions that affect the reported amounts of assets and liabilities, revenues, and expenses and related disclosures of
contingent assets and liabilities in the consolidated financial statements and accompanying notes. The SEC defines a companys critical accounting policies as the ones that are most important to the portrayal of the companys financial
condition and results of operations, and that require the company to make its most difficult and subjective judgments, often as a result of the need to make estimates of matters that are inherently uncertain. Based on this definition, we have
identified the significant accounting policies and judgments addressed below. We also have other key accounting policies that involve the use of estimates, judgments, and assumptions that are significant to understanding our results. We have
included additional information about our significant accounting policies in Note 1 of our consolidated financial statements included in Part IV, Item 15 of this annual report. Although we believe that our estimates, assumptions, and judgments
are reasonable, they are based on information presently available. Actual results may differ significantly from these estimates under different assumptions, judgments, or conditions. In addition, any significant unanticipated changes in any of our
assumptions could have a material adverse effect on our business, financial condition, and results of operations.

Revenue
Recognition

We recognize revenues in accordance with SEC Staff Accounting Bulletin No. 104, Revenue Recognition.We
recognize revenue when the following revenue recognition criteria are met: (1) persuasive evidence of an



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arrangement exists; (2) delivery has occurred or services have been rendered; (3) the selling price or fee earned is fixed or determinable; and
(4) collection of the resulting receivable is reasonably assured.

OTC ̧ Vision, and Mail-Order.We record revenues from
sales of OTC, vision, and mail-order pharmacy when the products are shipped and title passes to customers, net of promotional discounts, cancellations, rebates, and returns allowances. We generally require payment by credit card at the point of
sale. We estimate return allowances, which reduce product sales by our estimate of expected product returns, based on our historical experience. Historically, product returns have not been significant and have not differed significantly from our
estimates.

From time to time, we provide incentive offers to our customers to encourage purchases. Such offers include discounts on
specific current purchases, or future rebates based on a percentage of the current purchase, as well as other offers. We treat discounts, when our customers accept them, as a reduction in the sales price of the related transaction and we present
them as a net amount in net sales. We treat rebates as a reduction in the sales price based on estimated redemption rates. We estimate redemption rates using our historical experience for similar offers. Historically, our redemption rates have not
differed materially from our estimates, which we adjust quarterly.

We also evaluate the criteria of Emerging Issues Task Force Issue
No. 99-19, Reporting Revenue Gross as a Principal Versus Net as an Agent, or EITF 99-19. Generally, when we are the primary party obligated in a transaction, are subject to inventory risk, have latitude in establishing prices and
selecting suppliers, or have several but not all of these indicators, we record revenue on a gross basis. If we are not primarily obligated and amounts earned are determined using a fixed percentage, a fixed-payment schedule, or a combination of the
two, we record revenue on a net basis. We record revenues generated by the GNC agreement in our OTC segment on a net basis because we do not take title to the inventory and do not establish pricing. We record revenues generated by the Weil agreement
in our OTC segment on a net basis, because we act as an agent, based on the fact that we earn a fixed dollar amount per customer transaction regardless of the amount billed to the customer, and we do not bear general inventory risk associated with
these sales We record revenues generated from the Amazon.com agreement in our OTC segment on a gross basis, because we act as a principal, based on the fact that we are subject to inventory risk, have latitude in establishing prices and selecting
suppliers. Prior to this agreement, effective November 9, 2005, we terminated a separate fulfillment agreement with Amazon.com. Under the terminated agreement, we recorded fulfillment fees and revenues on a gross basis, because we acted as a
principal and bore general inventory risk. We record revenues generated from our drop-ship arrangements with vendors agreement in our OTC segment on a gross basis when we are the primary party obligated in a transaction, are subject to inventory
risk, have latitude in establishing prices and selecting suppliers, or have several but not all of these indicators.

We also evaluate the
criteria of Emerging Issues Task Force Issue No. 00-21, Revenue Arrangements with Multiple Deliverables, or EITF 00-21, when we enter into arrangements with multiple deliverables. EITF 00-21 establishes three criteria that must be met in
order for the deliverables in the arrangement to be treated as separate units of accounting; (1) the delivered item has value on a stand-alone basis; (2) there is objective and reliable evidence of the fair value of the undelivered item;
and (3) delivery or performance of the undelivered item is considered probable and substantially in the control of the vendor. When the separation criteria are not met, the delivered item is accounted for as a combined unit of accounting with
the undelivered item. Therefore, revenue for the delivered and undelivered items is recognized over the service period of the last delivered item or if it is not a service, when the last item is delivered.

Prescription Sales.For insured prescriptions in both our local pick-up and mail-order segments, the co-payment and the insurance reimbursement
(which together make up the amount due to drugstore.com) constitute the full value of the prescription drug sale, and we receive this entire amount as cash. We therefore recognize the entire amount as revenue when we ship the order to the customer
(for mail order prescriptions) or when the customer picks up the order (for local pick-up prescriptions).



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Local Pick-up.We recognize revenues from sales of prescription products ordered online or by
telephone through the drugstore.com web store or the RiteAid.com web store (which is powered by the drugstore.com web store) for pick-up at a Rite Aid store, including co-payments that Rite Aid receives and collects on our behalf when the customer
picks up the product. In these circumstances, we use Rite Aid as our fulfillment partner. We record revenues in our local pick-up pharmacy segment on a gross basis, because we act as a principal, based on the fact that, among other things, we bear
both inventory risk and credit and collection risk associated with these sales.

Inventories

We value our inventories at the lower of cost (using the weighted-average cost method) or the current estimated market value. We regularly review
inventory quantities on hand and adjust our inventories for shrinkage and slow-moving, damaged, and expired inventory, which we record as the difference between the cost of the inventory and the estimated market value based on managements
assumptions about future demand for the products we offer and market conditions. We use a variety of methods to reduce the quantity of slow-moving inventory, including reducing sales prices on our websites, negotiating returns to vendors, and
liquidating inventory through third parties. If our estimates of future product demand or our assumptions about market conditions are inaccurate, we could understate or overstate the provision required for excess and obsolete inventory.
Historically, inventory reserves have not differed materially from our estimates.

Goodwill and Other Intangible Assets

In accordance with Statement of Financial Accounting Standards No. 142, Accounting for Goodwill and Other Intangibles,
or SFAS 142, we test for impairment of goodwill at the beginning of the fourth quarter and whenever indicators of impairment occur. The first phase of the test screens for impairment. If we determine impairment, the second phase measures the amount
of impairment by comparing the fair value of the applicable reporting unit to its carrying value. We determine fair value using either a discounted cash flow methodology or methodology based on comparable market prices. This analysis uses a
multi-year forecast of estimated cash flows and a terminal value at the end of the cash flow period. The forecast period assumptions consist of internal projections that are based on our budget and long-range strategic plan. The discount rate used
at the testing date is our weighted-average cost of capital. The assumptions included in the discounted cash flow analysis require judgment, and changes to these inputs could materially impact the results of the calculation.

We review our indefinite-lived intangible assets for impairment when indicators of impairment occur and annually at the beginning of the fourth quarter.
We compare the carrying value of the asset to its estimated fair value and record an impairment charge when the carrying value of the asset exceeds the estimated fair value.

In accordance with Statement of Financial Accounting Standards No. 144,Accounting for the Impairment or Disposal of Long-Lived Assets, or
SFAS 144, we review the carrying values of our amortized long-lived assets, including definite-lived intangible assets, whenever an indicator of impairment occurs. When facts and circumstances indicate that the carrying values of long-lived assets
may be impaired, we perform an evaluation of recoverability. We determine whether impairment exists based on any excess of the carrying value over the expected future cash flows, as estimated through undiscounted cash flows, excluding interest
charges. We measure any resulting impairment charge based on the difference between the carrying value of the asset and its fair value, as estimated through expected future discounted cash flows, discounted at a rate of return for an alternate
investment.

Stock-Based Compensation

We measure compensation cost for all stock-based awards at fair value on the date of grant and recognition of compensation over the service period for awards expected to vest. We calculate the fair value of our stock
options granted to employees using the Black-Scholes option pricing model using the single-option approach.



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This fair value is then amortized on a straight-line basis over the requisite service periods of the awards, which is generally the vesting period. We base
our computation of expected volatility on our historical volatility, adjusted for changes in capital structure and corporate changes, information available that may indicate future volatility, and observable mean reversion tendencies of historical
volatility. Through the third quarter of 2007, we computed expected life of stock-based awards using the simplified method outlined by SEC Staff Accounting Bulletin No. 107, Share-Based Payment, or SAB 107. Under this method, our
expected term was equal to the sum of the weighted average vesting term plus the original contractual term divided by two, which resulted in a six-year expected term. In the fourth quarter of 2007, we developed reasonable and supportable expected
term estimates utilizing a comprehensive weighted average life (WAL) analysis. The WAL analysis provides a historical based platform for use in developing expected term estimates for the future based on the historically observed time periods from
grant date through post-vesting activities, such as exercise and cancellation. We base the risk-free interest rate on the implied yield currently available on U.S. Treasury zero-coupon issues with an equivalent remaining term. Where the expected
term of our stock-based awards does not correspond with the terms for which interest rates are quoted, we average the rates quoted for the closest available term maturities. A dividend yield of 0% is considered appropriate as we have not issued and
do not anticipate issuing any dividends in the near future. When estimating forfeitures, we consider historical voluntary termination behavior in addition to actual option forfeitures. In conjunction with this analysis, we identified distinct
subgroups: non-management employees, management employees, our chief executive officer, board members, and other non-employees. We apply an estimated forfeiture rate of approximately 35% to non-management and management employee subgroups, based on
the weighted average termination behavior of those subgroups. We apply a forfeiture rate of 0% to our chief executive officer, board members, and non-employees. If our estimated forfeiture rate changes, we retrospectively increase or decrease
stock-based compensation in the period of change. Any such revisions to the estimates we use to calculate the fair value of our stock-based awards could have a material impact on our results of operations and financial position. See Note 11 of
our consolidated financial statements, Employee Benefit Plans, included in Part IV, Item 15 of this annual report.

Legal
Proceedings

We are currently involved in various claims and legal proceedings. Periodically, we review the status of each
significant matter and assess our potential financial exposure. If the potential loss from any claim or legal proceeding is considered probable and the amount can be estimated, we accrue a liability for the estimated loss. Because of uncertainties
related to these matters, accruals are based only on the best information available at the time. As additional information becomes available, we reassess the potential liability related to our pending claims and legal proceedings and may revise our
estimates. Any such revisions in the estimates of the potential liabilities could have a material impact on our future results of operations and financial position. For a description of our material legal proceedings, see Note 8 of our
consolidated financial statements, Commitments and Contingencies, included in Part IV, Item 15 of this annual report.

Recent Accounting
Pronouncements

See Note 1 of our consolidated financial statements, The Company and Summary of Significant
Accounting PoliciesNew Accounting Pronouncements, included in Part IV, Item 15 of this annual report.

Liquidity and
Capital Resources

We have incurred net losses of $761.9 million since inception. To date, we have not been profitable, and we may never
achieve profitability on a full-year or consistent basis. We expect to continue to incur net losses in the first quarter of 2008, and possibly longer. As a result, our stock price may decline and stockholders may lose all or a part of their
investment in our common stock. From our inception through December 30, 2007, we have financed our operations primarily through the sale of equity securities, including common and preferred stock, yielding net cash proceeds of $420.7 million.



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Discussion of Cash Flows

The following table provides information regarding our cash flows for the last three fiscal years:



|                                                     |  |                  |        |   |          |   |        |      |  |   |          |   |  |      |         |   |  |   |         |  
|---------------------------------------------------- |  | ---------------- | ------ | - | -------- | - | ------ | ---- |  | - | -------- | - |  | ---- | ------- | - |  | - | ------- | -
|                                                     |  | Fiscal Year      |       
|                                                     |  | 2007             |        |   | $ Change |   |        | 2006 |  |   | $ Change |   |  | 2005 |        
|                                                     |  | ($ in thousands) |       
|Net cash provided by (used in) operating activities  |  | $                | 7,778  |   |          | $ | 8,861  |      |  | $ | (1,083   | ) |  | $    | 8,720   |   |  | $ | (9,803  | )
|Net cash used in investing activities                |  | $                | (5,108 | ) |          | $ | 3,534  |      |  | $ | (8,642   | ) |  | $    | 4,839   |   |  | $ | (13,481 | )
|Net cash provided by financing activities            |  | $                | 2,509  |   |          | $ | (318   | )    |  | $ | 2,827    |   |  | $    | (25,257 | ) |  | $ | 28,084  |  
|Net increase (decrease) in cash and cash equivalents |  | $                | 5,179  |   |          | $ | 12,077 |      |  | $ | (6,898   | ) |  | $    | (11,698 | ) |  | $ | 4,800   |  

Net cash provided by operating activities in 2007 reflects non-cash expenses of $19.8 million,
offset by net losses of $11.5 million and uses of other working capital of $0.5 million. In 2006 and 2005 net cash used in operating activities primarily reflects net losses and changes in operating assets and liabilities, partially offset by
non-cash expenses. Net cash provided by operating activities increased in 2007 compared to the prior year, primarily as a result of a decrease in net loss of $1.5 million, an increase in non-cash expenses of $2.7 million, and a decrease of $4.7
million in uses of other working capital, primarily due to increases in inventory to support our growing sales. Net cash used in operating activities decreased in 2006 compared to the prior year, primarily as a result of a decrease in our net loss
of $7.9 million and increases in non-cash expenses of $3.8 million, offset by an increase of $3.0 million in uses of other working capital.

Net cash used in investing activities in 2007, 2006, and 2005 was primarily attributable to the purchase of marketable securities and the acquisition of fixed assets and intangible assets partially offset by the net proceeds received from
the sales and maturities of marketable securities. Net cash used in investing activities decreased in 2007 compared to 2006, primarily due to an increase in sales and maturities of marketable securities of $15.4 million, partially offset by an
increase in the acquisition of fixed assets and intangible assets of $7.2 million and an increase in purchases of marketable securities of $4.7 million. Net cash used in investing activities decreased in 2006 compared to 2005, primarily due to a
decrease in purchases of marketable securities of $15.0 million, partially offset by a decrease in sales and maturities of marketable securities of $8.7 million and an increase in the acquisition of fixed assets of $1.5 million.

Net cash provided by financing activities in 2007 and 2006 was attributable to cash provided from exercises of employee stock options, borrowings under
our revolving line of credit with a bank and asset financings, partially offset by payments on our debt obligations. Net cash provided by financing activities in 2005 was primarily attributable to $26.0 million of net proceeds received from the sale
of 10.0 million shares of our common stock, in addition to cash provided from exercises of employee stock options, borrowings under our revolving line of credit agreement with a bank, and proceeds from term loans and asset financings, partially
offset by payments on our debt obligations.

Until required for other purposes, our cash and cash equivalents are maintained in deposit
accounts or highly liquid investments with remaining maturities of 90 days or less at the time of purchase. Our marketable securities, which include commercial paper, corporate notes, and government and private placement bonds, are considered
short-term as they are available to fund current operations.

The following table provides information regarding our balances of cash and
cash equivalents and marketable securities for the last three fiscal years:



|                          |  |                  |        |                  |   |                |  |   |       
|------------------------- |  | ---------------- | ------ | ---------------- | - | -------------- |  | - | ------
|                          |  | December 30,2007 |        | December 31,2006 |   | January 1,2006
|                          |  | (in thousands)  
|Cash and cash equivalents |  | $                | 18,572 |                  | $ | 13,393         |  | $ | 20,291
|Marketable securities     |  |                  | 17,677 |                  |   | 27,246         |  |   | 26,172
|                          |  |                  |        |                  |   |                |  |   |       
|Total                     |  | $                | 36,249 |                  | $ | 40,639         |  | $ | 46,463
|                          |  |                  |        |                  |   |                |  |   |       



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Liquidity Sources, Requirements and Contractual Cash Requirements and Commitments

Our principal sources of liquidity are our cash, cash equivalents, and marketable securities. Historically, our principal liquidity requirements have been
to meet our working capital and capital expenditure needs.

Our primary source of cash is sales made through our websites, for which we
collect cash from credit card settlements or insurance reimbursements. Our primary uses of cash are purchases of inventory, salaries, marketing expenses, and overhead and fixed costs. Any projections of our future cash needs and cash flows are
subject to substantial uncertainty for the reasons discussed in this section and in the section entitled Risk Factors in Part I, Item 1A of this annual report.

In December 2004, we entered into an amended and restated loan and security agreement with a bank. In January 2005, we borrowed $1.0 million on the line
of credit and in December 2005, we converted the $1.0 million line of credit into a term loan. The term loan totaled $361,000 and $694,000 as of December 30, 2007 and December 31, 2006, respectively, and is payable in 36 monthly
installments of principal and interest at a rate of prime rate plus 0.50% (7.75% at December 30, 2007 and 8.75% at December 31, 2006). In addition, the agreement includes a $2.0 million term loan for capital equipment expenditures that
accrues interest on the outstanding principal balance at a rate of prime rate plus 0.50%. This term loan is payable in 36 equal monthly installments of principal, plus accrued interest, beginning on February 1, 2005 and ending on
January 1, 2008. The balance outstanding under this term loan was $55,000 and $722,000 as December 30, 2007 and December 31, 2006, respectively. Our equipment, inventory, accounts receivable, cash, and intangible assets collateralize
the borrowings under the agreement. The agreement contains certain financial and non-financial covenants with which we were in compliance at December 30, 2007.

In April 2007, we amended our amended and restated loan and security agreement with our existing bank. The current agreement includes a revolving line of credit allowing for borrowings of up to $10.0 million, which
accrue interest at the prime rate (7.25% at December 31, 2007). The revolving line of credit matures in March 2008. The agreement allows for the conversion of up to $2.5 million of the outstanding balance into a term loan within 60 days of
maturity. For the year ended December 30, 2007, borrowings under the existing line of credit totaled $4.0 million, of which $1.0 million was converted into a term loan in April 2007, $2.5 million was repaid and $1.5 million remains outstanding
as of December 30, 2007. The term loan totaled $778,000 as of December 30, 2007 and is payable in 36 monthly installments of principal and interest at a rate of prime rate plus 0.50% (7.75% at December 30, 2007)

In October 2005, we entered into an agreement to lease computer equipment under a non-cancelable capital lease. With respect to each draw under this
lease, 63.5% of the sum of the draw amount plus interest determined at the time of the draw was payable in monthly installments over the 24 months following the draw. At the end of the 24-month period, we had the option to either pay the remaining
36.5% in a single balloon payment or extend financing for an additional 12 months. All draws under this lease, which were limited to $1.2 million, were completed by June 2006. We had drawn the entire $1.2 million under this lease, payable in 24
monthly installments of $37,600 at an interest rate of 9.4%. As of December 30, 2007, we had paid off the lease, including the balloon payment of $432,000. As of December 31, 2006, the amount due under the agreement was $789,000.

In July 2006, we entered into an agreement to finance equipment in our distribution center totaling $1.9 million under a non-cancelable
capital lease. The lease is payable in 36 monthly installments of approximately $60,000 beginning January 2007 and ending December 2009, and accrues interest at a rate of 8%. As of December 30, 2007 and December 31, 2006, the amount due
under the agreement was $1.3 million and $1.9 million, respectively.

We also lease computer equipment under non-cancelable capital leases.
Capital lease obligations bear interest at rates ranging from 7% to 8% and mature 21 to 60 months from the date of funding. We secured additional funds of $469,000 during 2007 and $373,000 during 2006, through capital lease financing agreements,



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through which we financed certain computer equipment, software, fixtures, and equipment for periods of two and three years. As of December 30, 2007, we
are in compliance with all covenants required by these agreements. These amounts are included in the table below within the category of capital leases.

As of December 30, 2007, our principal commitments consisted of obligations outstanding under capital and operating leases, our line of credit, and our term loans, as follows (in thousands):



|                                 |  |                       |        |          |   |           |  |           |       |           |   |       |  |   |  
|-------------------------------- |  | --------------------- | ------ | -------- | - | --------- |  | --------- | ----- | --------- | - | ----- |  | - | -
|                                 |  | Payment Due by Period
|                                 |  | Total                 |        | < 1 year |   | 1-3 years |  | 3-5 years |       | > 5 years
|                                 |  | ($ in thousands)     
|Capital leases(1)                |  | $                     | 1,834  |          | $ | 1,058     |  | $         | 776   |           | $ |      |  | $ | 
|Term loans and Line of Credit(2) |  |                       | 2,795  |          |   | 2,295     |  |           | 500   |           |   |      |  |   | 
|Operating leases(3)              |  |                       | 12,911 |          |   | 2,992     |  |           | 7,556 |           |   | 2,363 |  |   | 
|                                 |  |                       |        |          |   |           |  |           |       |           |   |       |  |   |  
|                                 |  | $                     | 17,540 |          | $ | 6,345     |  | $         | 8,832 |           | $ | 2,363 |  | $ | 
|                                 |  |                       |        |          |   |           |  |           |       |           |   |       |  |   |  



|(1) | Capital lease obligations consist primarily of technology and
operations assets.
|--- | --------------------------------------------------------------------------------

|(2) | Term loans and line of credit include debt obligations with a bank.
|--- | -------------------------------------------------------------------

|(3) | Operating lease obligations consist of office building, distribution center, and call center leases.
|--- | ----------------------------------------------------------------------------------------------------

We do not have any future material noncancelable commitments to purchase goods or services.

We believe that our cash and marketable securities on hand plus our sources of cash will be sufficient to fund our operations and anticipated capital
expenditures for the next twelve months. However, any projections about our future cash needs and cash flows are subject to substantial uncertainty. As a result, we may need to raise additional monies to fund our operating activities or for
strategic flexibility (if, for example, we decide to pursue business or technology acquisitions) or if our expectations regarding our operations and anticipated capital expenditures change. We have assessed in the past, and will continue to assess,
opportunities for raising additional funds by selling equity, equity-related or debt securities, obtaining additional credit facilities, or obtaining other means of financing for strategic reasons or to further strengthen our financial position. We
cannot be certain that additional financing will be available to us on acceptable terms when required, or at all. Furthermore, if we were to raise additional funds through the issuance of securities, such securities may have rights, preferences, or
privileges senior to those of the rights of our common stock and our stockholders may experience additional dilution.

Off-Balance Sheet Arrangements

We have no material off-balance sheet arrangements.

Management Outlook

For the first quarter of fiscal year 2008, we are targeting net sales in the
range of $118.0 million to $122.0 million. We anticipate a net loss for the first quarter in the range of $2.4 million to $2.9 million. For fiscal year 2008, we are targeting net sales in the range of $498.0 million to $512.0 million. We anticipate
net income (loss) in the range of $(1.0) million to $3.0 million for the year.

These projections are subject to substantial uncertainty.
See Risk Factors in Part I, Item 1A of this annual report and Special Note Regarding Forward-Looking Statements above.



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|ITEM 7A. | QUANTITATIVE AND QUALITATIVE DISCLOSURE ABOUT MARKET RISK
|-------- | ---------------------------------------------------------

We have assessed our vulnerability to certain market risks, including interest rate risk associated with marketable securities, accounts receivable, accounts payable, capital lease obligations, and cash and cash equivalents. Due to the
short-term nature of these investments and our investment policies and procedures, we have determined that the risk associated with interest rate fluctuations related to these financial instruments is not material to us.

We have interest rate exposure arising from our financing facilities, which have variable rates. These variable interest rates are affected by changes in
short-term interest rates. We manage our interest rate exposure by maintaining a conservative debt-to-equity ratio. We believe that the effect, if any, of reasonably possible near-term changes in interest rates on our financial position, results of
operations, and cash flows will not be material. Our financing facilities expose our net earnings to changes in short-term interest rates because interest rates on the underlying obligations are variable. Borrowings outstanding under the variable
interest-bearing financing facilities totaled $2.7 million at December 30, 2007, and the highest interest rate attributable to this outstanding balance was 7.75% at December 30, 2007. A change in net earnings resulting from a hypothetical
10% increase or decrease in interest rates would not be material.

We have investment risk exposure arising from our investments in
marketable securities due to volatility of the stock market in general, company-specific circumstances, and changes in general economic conditions. As of December 30, 2007, we had $17.7 million of securities classified as marketable
securities. We regularly review the carrying value of our investments and identify and record losses when events and circumstances indicate that declines in the fair value of such assets below our accounting basis are other-than-temporary.



|ITEM 8. | FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA
|------- | -------------------------------------------

The
financial statements required pursuant to this item are filed under Part IV, Item 15(a)(1) of this annual report. The financial statement schedule required under Regulation S-X is filed under Part IV, Item 15(a)(2) of this annual report.



|ITEM 9. | CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL DISCLOSURE
|------- | ------------------------------------------------------------------------------------

None.



|ITEM 9A. | CONTROLS AND PROCEDURES
|-------- | -----------------------

Evaluation of Disclosure Controls and
Procedures

Under the supervision of and with the participation of our management, including our chief executive officer and chief
financial officer, we performed an evaluation of the effectiveness of our disclosure controls and procedures (as defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934, as amended, or the Exchange Act). Based on that
evaluation, our management, including our chief executive officer and chief financial officer, concluded that, as of December 30, 2007, our disclosure controls and procedures were effective to provide reasonable assurance that all material
information required to be disclosed in reports filed or submitted by us under the Exchange Act is made known to management in a timely fashion.

The certifications required by Section 302 of the Sarbanes-Oxley Act of 2002 are filed as exhibits 31.1 and 31.2, respectively, in this Form 10-K.



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Managements Report on Internal Control over Financial Reporting

Management is responsible for establishing and maintaining an adequate system of internal control over financial reporting (as defined in Rules 13a-15(f)
and 15d-15(f)) under the Exchange Act). Management evaluated the effectiveness of our internal control over financial reporting based on criteria established in Internal ControlIntegrated Frameworkissued by the Committee of Sponsoring
Organizations of the Treadway Commission, or COSO. Based on its evaluation, management concluded that, as of December 30, 2007, our system of internal control over financial reporting was effective. Ernst & Young LLP, an independent
registered public accounting firm, has issued an attestation report on the effectiveness of our internal control over financial reporting as of December 30, 2007, a copy of which is included in this annual report.

Changes in Internal Control over Financial Reporting

There were no changes in our internal control over financial reporting during the most recently completed fiscal quarter that have materially affected, or are reasonably likely to materially affect, our internal controls over financial
reporting.

Limitations on Controls

Management does not expect that our disclosure controls and procedures or our internal control over financial reporting will prevent or detect all error and fraud. Any control system, no matter how well designed and operated, is based on
certain assumptions and can provide only reasonable, not absolute, assurance that its objectives will be met. In addition, no evaluation of controls can provide absolute assurance that misstatements due to error or fraud will not occur or that all
control issues and instances of fraud, if any, within drugstore.com have been detected.



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Report of Independent Registered Public Accounting Firm

The Board of Directors and Stockholders

drugstore.com, inc.

We have audited drugstore.com, inc.s internal control over financial reporting as of December 30, 2007, based on criteria established in Internal
ControlIntegrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission (the COSO criteria). drugstore.com, inc.s management is responsible for maintaining effective internal control over financial
reporting, and for its assessment of the effectiveness of internal control over financial reporting included in the accompanying Managements Report on Internal Control over Financial Reporting. Our responsibility is to express an opinion on
the companys internal control over financial reporting based on our audit.

We conducted our audit in accordance with the standards of the Public
Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether effective internal control over financial reporting was maintained in all material respects.
Our audit included obtaining an understanding of internal control over financial reporting, assessing the risk that a material weakness exists, testing and evaluating the design and operating effectiveness of internal control based on the assessed
risk, and performing such other procedures as we considered necessary in the circumstances. We believe that our audit provides a reasonable basis for our opinion.

A companys internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in
accordance with generally accepted accounting principles. A companys internal control over financial reporting includes those policies and procedures that (1) pertain to the maintenance of records that, in reasonable detail, accurately
and fairly reflect the transactions and dispositions of the assets of the company; (2) provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally accepted
accounting principles, and that receipts and expenditures of the company are being made only in accordance with authorizations of management and directors of the company; and (3) provide reasonable assurance regarding prevention or timely
detection of unauthorized acquisition, use, or disposition of the companys assets that could have a material effect on the financial statements.

Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become
inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.

In our opinion,
drugstore.com, inc. maintained, in all material respects, effective internal control over financial reporting as of December, 30 2007, based on the COSO criteria.

We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States), the consolidated balance sheets of drugstore.com, inc. as of December 30, 2007 and
December 31, 2006, and the related consolidated statements of operations, stockholders equity, and cash flows for each of the three years in the period ended December 30, 2007 of drugstore.com, inc., and our report dated
March 13, 2008 expressed an unqualified opinion thereon.

/s/ Ernst & Young LLP

Seattle, Washington

March 13, 2008



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|ITEM 9B. | OTHER INFORMATION
|-------- | -----------------

None.

PART III



|ITEM 10. | DIRECTORS, EXECUTIVE OFFICERS, AND CORPORATE GOVERNANCE
|-------- | -------------------------------------------------------

Directors and Executive Officers

Information regarding our executive officers required by Part III, Item 10 is set
forth in the section entitled BusinessDirectors and Officers in Part I, Item 1 of this annual report. Information regarding our directors required by Part III, Item 10 is incorporated into this annual report by
reference to the section entitled Proposal No. 1Election of Directors in our proxy statement for our annual meeting of stockholders to be held on June 12, 2008, or the 2008 Proxy Statement.

Information relating to compliance with Section 16(a) of the Securities Exchange Act of 1934, as amended, required by Part III, Item 10 is
incorporated into this annual report by reference to the section entitled Section 16 Beneficial Ownership Reporting Compliance in the 2008 Proxy Statement.

Code of Business Conduct and Ethics

Our board
of directors has adopted a code of business conduct and ethics, or Code, applicable to all directors, officers and employees of drugstore.com, including our chief executive officer, chief financial officer, chief accountant, and controller. You may
obtain a copy of the Code, without charge, on written request to Investor Relations, drugstore.com, inc., 411 108thAvenue NE, Suite 1400, Bellevue,
Washington 98004, or by calling (425) 372-3200.



|ITEM 11. | EXECUTIVE COMPENSATION
|-------- | ----------------------

Information regarding
executive compensation required by Part III, Item 11 is incorporated into this annual report by reference to the section entitled Executive Compensation in the 2008 Proxy Statement.



|ITEM 12. | SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDER MATTERS
|-------- | ----------------------------------------------------------------------------------------------

Information regarding our equity compensation plans required by Part III, Item 12 is set forth in the section entitled Securities Authorized
for Issuance under Equity Compensation Plans in the 2008 Proxy Statement.

Information regarding security ownership of certain
beneficial owners and management and related stockholder matters required by Part III, Item 12 is incorporated into this annual report by reference to the section entitled Security Ownership of Certain Beneficial Owners and
Management in the 2008 Proxy Statement.



|ITEM 13. | CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCE
|-------- | -------------------------------------------------------------------------

Information regarding certain relationships and related transactions required by Part III, Item 13 is incorporated into this annual report by reference to the section entitled Transactions with Related
Persons in the 2008 Proxy Statement.



|ITEM 14. | PRINCIPAL ACCOUNTING FEES AND SERVICES
|-------- | --------------------------------------

Information
regarding principal accountant fees and services required by Part III, Item 14 is incorporated into this annual report by reference to the section entitled Proposal No. 3Ratification of Appointment of Independent Public
Accounting Firm in the 2008 Proxy Statement.



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PART IV



|ITEM 15. | EXHIBITS, FINANCIAL STATEMENT SCHEDULES.
|-------- | ----------------------------------------

(a) The following documents are filed as a part of this annual report on Form 10-K:



| | 1. | Index to Consolidated Financial Statements:
| | -- | -------------------------------------------



|                                                        |  |     
|------------------------------------------------------- |  | ----
|                                                        |  | Page
|Report of Independent Registered Public Accounting Firm |  | 55  
|Consolidated Balance Sheets                             |  | 56  
|Consolidated Statements of Operations                   |  | 57  
|Consolidated Statements of Stockholders Equity         |  | 58  
|Consolidated Statements of Cash Flows                   |  | 59  
|Notes to Consolidated Financial Statements              |  | 60  



| | 2. | Index to Financial Statement Schedules:
| | -- | ---------------------------------------



|                                              |  |   
|--------------------------------------------- |  | --
|Schedule IIValuation and Qualifying Accounts |  | 88

All other schedules have been omitted because the required information is shown in the
consolidated financial statements or the accompanying notes, or is not applicable or required.



| | 3. | Index of Exhibits:
| | -- | ------------------



|            |  |                                                                                                                                                                                                                                                                                                                               
|----------- |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit No. |  | Exhibit Description                                                                                                                                                                                                                                                                                                           
|            | 
|3.1         |  | Amended and Restated Certificate of Incorporation of drugstore.com, inc. (incorporated by reference to Exhibit 3.2 to drugstore.com, inc.s Registration Statement on Form S-1 filed February
9, 2000 (Registration No. 333-96441)).                                                                                          
|            | 
|3.1a        |  | Certificate of Designation of Series 1 Preferred Stock of drugstore.com, inc. (incorporated by reference to Exhibit 3.1a to drugstore.com, inc.s Quarterly Report on Form 10-Q for the
Quarter Ended July 2, 2000 (SEC File No. 000-26137)).                                                                                 
|            | 
|3.2         |  | Amended and Restated Bylaws of drugstore.com, inc. dated January 7, 2005 (incorporated by reference to Exhibit 3.2 to drugstore.com inc.s Annual Report on Form 10-K for the Fiscal Year
Ended January 1, 2006 (SEC File No. 000-26137)).                                                                                    
|            | 
|4.1         |  | Warrant issued to Highbridge International LLC on December 8, 2003, on the cancellation of the warrant issued to Tel-Drug, Inc. on June 26, 2000 (incorporated by reference to Exhibit 4.1 to
drugstore.com inc.s Annual Report on Form 10-K for the Fiscal Year Ended January 2, 2005 (SEC File No. 000-26137)).            
|            | 
|4.2         |  | Warrant issued to Lehman Brothers, Inc. on November 16, 2006, on the cancellation of the warrant issued to Heidrick & Struggles, Inc. on February 14, 2005 (incorporated by reference to
Exhibit 4.2 to drugstore.com inc.s Annual Report on Form 10-K for the Fiscal Year Ended December 31, 2006 (SEC File No. 000-26137)).
|            | 
|4.3         |  | Form of Warrant issued on (incorporated by reference to Exhibit 4.1 to drugstore.com inc.s Quarterly Report on Form 10-Q for the Quarter Ended July 1, 2007 (SEC File No.
000-26137)).                                                                                                                                       
|            | 
|4.4         |  | Form of Warrant (incorporated by reference to Exhibit 4.1 to drugstore.com inc.s Quarterly Report on Form 10-Q for the Quarter Ended September 30, 2007 (SEC File No.
000-26137)).                                                                                                                                           



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|            |  |                                                                                                                                                                                                                                                                                                                                       
|----------- |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit No. |  | Exhibit Description                                                                                                                                                                                                                                                                                                                   
|            | 
|10.1        |  | Form of Indemnification Agreement between drugstore.com, inc. and each of its officers and directors (incorporated by reference to Exhibit 10.1 to drugstore.com, inc.s Registration
Statement on Form S-1 filed May 19, 1999 (Registration No. 333-78813)).                                                                         
|            | 
|10.2        |  | Fourth Amended and Restated Investors Rights Agreement dated May 19, 1999, among drugstore.com, inc. and certain investors (incorporated by reference to Exhibit 10.12 to drugstore.com,
inc.s Registration Statement on Form S-1/A filed July 8, 1999 (Registration No. 333-78813)).                                               
|            | 
|10.3        |  | Addendum dated June 17, 1999, to Fourth Amended and Restated Investors Rights Agreement dated May 19, 1999, among drugstore.com, inc. and certain investors (incorporated by reference to
Exhibit 10.25 to drugstore.com, inc.s Registration Statement on Form S-1/A filed June 28, 1999 (Registration No. 333-78813)).             
|            | 
|10.4        |  | Form of Second Addendum to Fourth Amended and Restated Investors Rights Agreement dated May 19, 1999, among drugstore.com, inc. and certain investors (incorporated by reference to
Exhibit 10.32 to drugstore.com, inc.s Registration Statement on Form S-1/A filed July 20, 1999 (Registration No. 333-78813)).                   
|            | 
|10.5        |  | Third Addendum dated January 24, 2000, to Fourth Amended and Restated Investors Rights Agreement dated May 19, 1999, among drugstore.com, inc. and certain investors (incorporated by
reference to Exhibit 10.38 to drugstore.com, inc.s Registration Statement on Form S-1 filed February 9, 2000 (Registration No. 333-96441)).   
|            | 
|10.6        |  | Fourth Addendum dated September 29, 2000, to Fourth Amended and Restated Investors Rights Agreement dated May 19, 1999, among drugstore.com, inc. and certain investors (incorporated by
reference to Exhibit 10.7 to drugstore.com, inc.s Registration Statement on Form S-3/A filed October 2, 2000 (Registration No. 333-45266)).
|            | 
|10.7        |  | Fifth Amended and Restated Voting Agreement dated December 23, 1999, among drugstore.com, inc. and certain founders and investors (incorporated by reference to Exhibit 10.20 to drugstore.com,
inc.s Registration Statement on Form S-1 filed February 9, 2000 (Registration No. 333-96441)).                                       
|            | 
|10.8        |  | 1998 Stock Plan, as amended June 21, 2000 (incorporated by reference to Exhibit 10.2 to drugstore.com, inc.s Quarterly Report on Form 10-Q for the Quarter Ended July 2, 2000) (SEC File No.
000-26137)).                                                                                                                            
|            | 
|10.9        |  | 1999 Employee Stock Purchase Plan, as amended (incorporated by reference to Exhibit 10.3 to drugstore.com, inc.s Registration Statement on Form S-1 filed February 9, 2000 (Registration No.
333-96441)).                                                                                                                            
|            | 
|10.10       |  | Main Agreement dated June 17, 1999, between drugstore.com, inc. and Rite Aid (incorporated by reference to Exhibit 10.27 to drugstore.com, inc.s Registration Statement on Form S-1/A filed
June 28, 1999 (Registration No. 333-78813)).                                                                                             
|            | 
|10.11       |  | Main Agreement dated June 17, 1999, between drugstore.com, inc. and General Nutrition Corporation (incorporated by reference to Exhibit 10.28 to drugstore.com, inc.s Registration Statement
on Form S-1/A filed June 28, 1999 (Registration No. 333-78813)).                                                                        
|            | 
|10.12       |  | Governance Agreement dated June 17, 1999, between drugstore.com, inc. and Rite Aid Corporation (incorporated by reference to Exhibit 10.29 to drugstore.com, inc.s Registration Statement on
Form S-1/A filed June 28, 1999 (Registration No. 333-78813)).                                                                           
|            | 
|10.13       |  | Governance Agreement dated June 17, 1999, among drugstore.com, inc., General Nutrition Corporation and General Nutrition Investment Company (incorporated by reference to Exhibit 10.30 to
drugstore.com, inc.s Registration Statement on Form S-1/A filed June 28, 1999 (Registration No. 333-78813)).                              



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|            |  |                                                                                                                                                                                                                                                                                                                                                                       
|----------- |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit No. |  | Exhibit Description                                                                                                                                                                                                                                                                                                                                                   
|            | 
|10.14       |  | Pharmacy Supply and Services Agreement dated June 17, 1999, between drugstore.com, inc. and Rite Aid Corporation (incorporated by reference to Exhibit 10.31 to drugstore.com, inc.s
Registration Statement on Form S-1/A filed June 28, 1999 (Registration No. 333-78813)).                                                                                         
|            | 
|10.15       |  | Amended and Restated Technology License and Advertising Agreement dated August 10, 1998, among drugstore.com, inc., Amazon.com and Amazon.com D, Inc. (incorporated by reference to Exhibit 10.14
to drugstore.com, inc.s Registration Statement on Form S-1/A filed July 26, 1999 (Registration No. 333-78813)).                                                    
|            | 
|10.16       |  | Registration Rights Agreement dated as of December 8, 2003 by and among drugstore.com, inc. and the other signatories thereto (incorporated by reference to Exhibit 10.1 to drugstore.com,
inc.s Current Report on Form 8-K filed December 23, 2003 (SEC File No. 000-26137)).                                                                                       
|            | 
|10.17       |  | Lease Agreement dated August 30, 1999, between DS Distribution, Inc. and the Northwestern Mutual Life Insurance Company (incorporated by reference to Exhibit 10.1 to drugstore.com, inc.s
Quarterly Report on Form 10-Q for the quarter ended October 3, 1999 (SEC File No. 000-26137)).                                                                            
|            | 
|10.18       |  | Amendment No. 1 to Lease Agreement dated December 10, 2003, between DS Distribution, Inc. and Liberty Vendor I, L.P (as successor in interest to the Northwestern Mutual Life Insurance Company)
(incorporated by reference to Exhibit 10.23 to drugstore.com inc.s Annual Report on Form 10-K for the Fiscal Year Ended December 28, 2003 (SEC File No. 000-26137)).
|            | 
|10.19       |  | Standard Industrial LeaseMulti-Tenant dated May 2, 2003 between Sam-Cher Holdings, Inc. and International Vision Direct, Inc. (incorporated by reference to Exhibit 10.24 to drugstore.com
inc.s Annual Report on Form 10-K for the Fiscal Year Ended December 28, 2003 (SEC File No. 000-26137)).                                                                  
|            | 
|10.20       |  | Sublease effective as of June 1, 2003 between Nova Scotia Power Incorporated and International Vision Direct Ltd. (incorporated by reference to Exhibit 10.25 to drugstore.com inc.s Annual
Report on Form 10-K for the Fiscal Year Ended December 28, 2003 (SEC File No. 000-26137)).                                                                               
|            | 
|10.21       |  | Office Lease dated May 1, 2003 between BTC Properties II Ltd. and International Vision Direct Ltd. (incorporated by reference to Exhibit 10.23 to drugstore.com inc.s Annual Report on
Form 10-K for the Fiscal Year Ended December 28, 2003 (SEC File No. 000-26137)).                                                                                              
|            | 
|10.22       |  | Office Lease Agreement dated August 16, 2004, between EOP-Northwest Properties, L.L.C. and drugstore.com, inc. (incorporated by reference to Exhibit 10.2 to drugstore.com, inc.s Quarterly
Report on Form 10-Q for the quarter ended September 26, 2004 (SEC File No. 000-26137)).                                                                                  
|            | 
|10.23       |  | Sub-Sublease Agreement dated August 16, 2004 and effective as of May 1, 2004, between EOP-Northwest Properties, L.L.C. and drugstore.com, inc. (incorporated by reference to Exhibit 10.3 to
drugstore.com, inc.s Quarterly Report on Form 10-Q for the quarter ended September 26, 2004 (SEC File No. 000-26137)).                                                  
|            | 
|10.24       |  | Amended and Restated Loan and Security Agreement dated December 29, 2004 (incorporated by reference to Exhibit 10.2 to drugstore.com, inc.s Quarterly Report on Form 10-Q for the quarter
ended April 2, 2006 (SEC File No. 000-26137)).                                                                                                                             
|            | 
|10.25       |  | Third Amendment to Loan and Security Agreement dated March 16, 2006 (incorporated by reference to Exhibit 10.1 to drugstore.com, inc.s Quarterly Report on Form 10-Q for the quarter ended
April 2, 2006 (SEC File No. 000-26137)).                                                                                                                                  
|            | 
|10.26       |  | Offer letter of Dawn Lepore dated September 21, 2004 (incorporated by reference to drugstore.com, inc.s Current Report on Form 8-K/A filed November 3, 2004 (SEC File No.
000-26137)).                                                                                                                                                                               
|            | 
|10.27       |  | Letter agreement with Dawn Lepore dated December 28, 2006 (incorporated by reference to drugstore.com, inc.s Current Report on Form 8-K filed December 29, 2006 (SEC File No. 000-26137)).                                                                                                                                                                           



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|            |  |                                                                                                                                                                                                                            
|----------- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit No. |  | Exhibit Description                                                                                                                                                                                                        
|            | 
|10.28       |  | Offer letter of Robert Hargadon dated October 30, 2006 (incorporated by reference to Exhibit 10.1 to drugstore.com, inc.s Current Report on Form 8-K filed December 4, 2006 (SEC File No.
000-26137)).                    
|            | 
|10.29       |  | Offer letter of Yukio Morikubo dated November 10, 2006 (incorporated by reference to Exhibit 10.2 to drugstore.com, inc.s Current Report on Form 8-K filed December 4, 2006 (SEC File No.
000-26137)).                    
|            | 
|10.30       |  | Transition and Separation Agreement of Robert A. Barton, dated January 30, 2007 (incorporated by reference to drugstore.com, inc.s Current Report on Form 8-K filed January 31, 2007 (SEC
File No. 000-26137)).           
|            | 
|10.31       |  | Offer letter of Thère du Pont dated May 15, 2007 (incorporated by reference to drugstore.com, inc.s Current Report on Form 8-K filed May 21, 2007 (SEC File No.
000-26137)).                                              
|            | 
|10.32       |  | Change of Control Agreement of Thère du Pont dated May 15, 2007 (incorporated by reference to drugstore.com, inc.s Current Report on Form 8-K filed May 21, 2007 (SEC File No.
000-26137)).                               
|            | 
|21.1*       |  | List of Subsidiaries.                                                                                                                                                                                                      
|            | 
|23.1*       |  | Consent of Independent Registered Public Accounting Firm.                                                                                                                                                                  
|            | 
|24.1        |  | Powers of Attorney (included on the signature page of this Annual Report on Form 10-K).                                                                                                                                    
|            | 
|31.1*       |  | Certification of Dawn G. Lepore, Chairman of Board, President and Chief Executive Officer of drugstore.com, inc., pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.                                               
|            | 
|31.2*       |  | Certification of Thère du Pont, Chief Financial Officer of drugstore.com, inc., pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.                                                                                 
|            | 
|32.1*       |  | Certification of Dawn G. Lepore, Chairman of Board, President and Chief Executive Officer of drugstore.com, inc., pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the
Sarbanes-Oxley Act of 2002.
|            | 
|32.2*       |  | Certification of Thère du Pont, Chief Financial Officer of drugstore.com, inc., pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.                                  



|* | Filed herewith
|- | --------------



54



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##### Table of Contents

Report of Independent Registered Public Accounting Firm

The Board of Directors and Stockholders

drugstore.com, inc.

We have audited the accompanying
consolidated balance sheets of drugstore.com, inc. as of December 30, 2007 and December 31, 2006, and the related statements of operations, stockholders equity, and cash flows for each of the three years in the period ended
December 30, 2007. Our audits also included the financial statement schedule listed in the Index at Item 15(a)2. These financial statements and schedule are the responsibility of the Companys management. Our responsibility is to
express an opinion on these financial statements and schedule based on our audits.

We conducted our audits in accordance with the
standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit
includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the
overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion.

In our opinion, the
financial statements referred to above present fairly, in all material respects, the consolidated financial position of drugstore.com, inc. at December 30, 2007 and December 31, 2006, and the consolidated results of its operations and its
cash flows for each of the three years in the period ended December 30, 2007, in conformity with U.S. generally accepted accounting principles. Also, in our opinion, the related financial statement schedule, when considered in relation to
the basic financial statements taken as a whole, presents fairly in all material respects the information set forth therein.

As discussed
in Note 1 to the consolidated financial statements, drugstore.com, inc. changed its method of accounting for stock-based compensation as of January 2, 2006 and its method of accounting for uncertain tax positions as of January 1, 2007.

We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States), drugstore.com,
inc.s internal control over financial reporting as of December 30, 2007, based on criteria established in Internal ControlIntegrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission and
our report dated March 13, 2008 expressed an unqualified opinion thereon.

/s/ Ernst & Young LLP

Seattle, Washington

March 13, 2008



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DRUGSTORE.COM, INC.

CONSOLIDATED BALANCE SHEETS

(in thousands, except share data)



|                                                                                                                                                  |  |                  |          |   |                  |   |          |  
|------------------------------------------------------------------------------------------------------------------------------------------------- |  | ---------------- | -------- | - | ---------------- | - | -------- | -
|                                                                                                                                                  |  | December 30,2007 |          |   | December 31,2006 |  
|Assets                                                                                                                                            |  |                  |          |   |                  |   |          |  
|Current assets:                                                                                                                                   |  |                  |          |   |                  |   |          |  
|Cash and cash equivalents                                                                                                                         |  | $                | 18,572   |   |                  | $ | 13,393   |  
|Marketable securities                                                                                                                             |  |                  | 17,677   |   |                  |   | 27,246   |  
|Accounts receivable, net of allowances                                                                                                            |  |                  | 38,063   |   |                  |   | 36,688   |  
|Inventories                                                                                                                                       |  |                  | 31,501   |   |                  |   | 26,469   |  
|Prepaid marketing expenses                                                                                                                        |  |                  | 2,327    |   |                  |   | 2,290    |  
|Other current assets                                                                                                                              |  |                  | 3,605    |   |                  |   | 2,615    |  
|                                                                                                                                                  |  |                  |          |   |                  |   |          |  
|Total current assets                                                                                                                              |  |                  | 111,745  |   |                  |   | 108,701  |  
|Fixed assets, net                                                                                                                                 |  |                  | 25,501   |   |                  |   | 18,293   |  
|Other intangible assets, net                                                                                                                      |  |                  | 4,598    |   |                  |   | 5,376    |  
|Goodwill                                                                                                                                          |  |                  | 32,202   |   |                  |   | 32,202   |  
|Prepaid marketing expenses and other                                                                                                              |  |                  | 1,362    |   |                  |   | 3,750    |  
|                                                                                                                                                  |  |                  |          |   |                  |   |          |  
|Total assets                                                                                                                                      |  | $                | 175,408  |   |                  | $ | 168,322  |  
|                                                                                                                                                  |  |                  |          |   |                  |   |          |  
|Liabilities and Stockholders Equity                                                                                                              |  |                  |          |   |                  |   |          |  
|Current liabilities:                                                                                                                              |  |                  |          |   |                  |   |          |  
|Accounts payable                                                                                                                                  |  | $                | 61,414   |   |                  | $ | 57,507   |  
|Accrued compensation                                                                                                                              |  |                  | 4,657    |   |                  |   | 4,841    |  
|Accrued marketing expenses                                                                                                                        |  |                  | 3,988    |   |                  |   | 3,661    |  
|Other current liabilities                                                                                                                         |  |                  | 4,312    |   |                  |   | 1,292    |  
|Current portion of long-term debt obligations                                                                                                     |  |                  | 3,179    |   |                  |   | 3,949    |  
|                                                                                                                                                  |  |                  |          |   |                  |   |          |  
|Total current liabilities                                                                                                                         |  |                  | 77,550   |   |                  |   | 71,250   |  
|Long-term debt obligations, less current portion                                                                                                  |  |                  | 1,221    |   |                  |   | 1,839    |  
|Deferred income taxes                                                                                                                             |  |                  | 947      |   |                  |   | 945      |  
|Other long-term liabilities                                                                                                                       |  |                  | 1,322    |   |                  |   | 1,610    |  
|Commitments and contingencies                                                                                                                     |  |                  |          |   |                  |   |          |  
|Stockholders equity:                                                                                                                             |  |                  |          |   |                  |   |          |  
|Preferred stock, $.0001 par value, 10,000,000 shares authorized, no shares issued and outstanding                                                 |  |                  |         |   |                  |   |         |  
|Common stock, $.0001 par value, stated at amounts paid in: 250,000,000 shares authorized, 96,296,687 and 94,335,027 shares issued and
outstanding |  |                  | 856,193  |   |                  |   | 843,026  |  
|Accumulated other comprehensive income (loss)                                                                                                     |  |                  | 27       |   |                  |   | (7       | )
|Accumulated deficit                                                                                                                               |  |                  | (761,852 | ) |                  |   | (750,341 | )
|                                                                                                                                                  |  |                  |          |   |                  |   |          |  
|Total stockholders equity                                                                                                                        |  |                  | 94,368   |   |                  |   | 92,678   |  
|                                                                                                                                                  |  |                  |          |   |                  |   |          |  
|Total liabilities and stockholders equity                                                                                                        |  | $                | 175,408  |   |                  | $ | 168,322  |  
|                                                                                                                                                  |  |                  |          |   |                  |   |          |  

See accompanying notes to consolidated financial statements.



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DRUGSTORE.COM, INC.

CONSOLIDATED STATEMENTS OF OPERATIONS

(in thousands, except share and per share data)



|                                                                                         |  |                    |            |   |                   |   |            |                 |  |   |            |  
|---------------------------------------------------------------------------------------- |  | ------------------ | ---------- | - | ----------------- | - | ---------- | --------------- |  | - | ---------- | -
|                                                                                         |  | For the year ended |           
|                                                                                         |  | December 30, 2007  |            |   | December 31, 2006 |   |            | January 1, 2006 | 
|Net sales                                                                                |  | $                  | 445,723    |   |                   | $ | 415,777    |                 |  | $ | 399,430    |  
|Costs and expenses:                                                                      |  |                    |            |   |                   |   |            |                 |  |   |            |  
|Cost of sales                                                                            |  |                    | 341,919    |   |                   |   | 326,036    |                 |  |   | 317,366    |  
|Fulfillment and order processing                                                         |  |                    | 44,200     |   |                   |   | 41,099     |                 |  |   | 39,855     |  
|Marketing and sales                                                                      |  |                    | 32,370     |   |                   |   | 29,735     |                 |  |   | 32,810     |  
|Technology and content                                                                   |  |                    | 18,258     |   |                   |   | 16,190     |                 |  |   | 12,773     |  
|General and administrative                                                               |  |                    | 20,928     |   |                   |   | 15,413     |                 |  |   | 15,791     |  
|Amortization of intangible assets                                                        |  |                    | 1,234      |   |                   |   | 2,060      |                 |  |   | 3,004      |  
|                                                                                         |  |                    |            |   |                   |   |            |                 |  |   |            |  
|Total costs and expenses                                                                 |  |                    | 458,909    |   |                   |   | 430,533    |                 |  |   | 421,599    |  
|                                                                                         |  |                    |            |   |                   |   |            |                 |  |   |            |  
|Operating loss                                                                           |  |                    | (13,186    | ) |                   |   | (14,756    | )               |  |   | (22,169    | )
|Interest income, net                                                                     |  |                    | 1,675      |   |                   |   | 1,730      |                 |  |   | 1,270      |  
|                                                                                         |  |                    |            |   |                   |   |            |                 |  |   |            |  
|Net loss                                                                                 |  | $                  | (11,511    | ) |                   | $ | (13,026    | )               |  | $ | (20,899    | )
|                                                                                         |  |                    |            |   |                   |   |            |                 |  |   |            |  
|Basic and diluted net loss per share                                                     |  | $                  | (0.12      | ) |                   | $ | (0.14      | )               |  | $ | (0.23      | )
|                                                                                         |  |                    |            |   |                   |   |            |                 |  |   |            |  
|Weighted average shares outstanding used to compute basic and diluted net loss per share |  |                    | 95,350,046 |   |                   |   | 93,405,405 |                 |  |   | 90,808,817 |  
|                                                                                         |  |                    |            |   |                   |   |            |                 |  |   |            |  



See accompanying notes to
consolidated financial statements.



57



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DRUGSTORE.COM, INC.

CONSOLIDATED STATEMENTS OF STOCKHOLDERS EQUITY

(in thousands, except share data)



|                                                                              |  |              |  |                                            |         |  |                    |    |   |       |   |          |   |  |   |         |  
|----------------------------------------------------------------------------- |  | ------------ |  | ------------------------------------------ | ------- |  | ------------------ | -- | - | ----- | - | -------- | - |  | - | ------- | -
|                                                                              |  | Common Stock |  | AccumulatedOtherComprehensiveIncome
(Loss) |         |  | AccumulatedDeficit |    |   | Total |  
|                                                                              |  | Shares       |  | Amount                                     |         |  |                   
|Balance at January 2, 2005                                                    |  | 81,440,927   |  | $                                          | 803,544 |  | $                  |   |   |       | $ | (716,416 | ) |  | $ | 87,128  |  
|                                                                              |  |              |  |                                            |         |  |                    |    |   |       |   |          |   |  |   |         |  
|Exercise of stock options                                                     |  | 1,325,773    |  |                                            | 1,797   |  |                    |   |   |       |   |         |   |  |   | 1,797   |  
|Employee stock purchase plan                                                  |  | 127,952      |  |                                            | 294     |  |                    |   |   |       |   |         |   |  |   | 294     |  
|Issuance of common stock in a private placement, net of issuance costs of $48 |  | 10,000,000   |  |                                            | 25,952  |  |                    |   |   |       |   |         |   |  |   | 25,952  |  
|Issuance of stock options and warrants for services                           |  |             |  |                                            | 328     |  |                    |   |   |       |   |         |   |  |   | 328     |  
|Issuance of common stock for license agreement                                |  | 10,000       |  |                                            | 34      |  |                    |   |   |       |   |         |   |  |   | 34      |  
|Stock-based compensation                                                      |  |             |  |                                            | 1,640   |  |                    |   |   |       |   |         |   |  |   | 1,640   |  
|Net loss and comprehensive loss                                               |  |             |  |                                            |        |  |                    | (3 | ) |       |   | (20,899  | ) |  |   | (20,902 | )
|                                                                              |  |              |  |                                            |         |  |                    |    |   |       |   |          |   |  |   |         |  
|Balance at January 1, 2006                                                    |  | 92,904,652   |  |                                            | 833,589 |  |                    | (3 | ) |       |   | (737,315 | ) |  |   | 96,271  |  
|                                                                              |  |              |  |                                            |         |  |                    |    |   |       |   |          |   |  |   |         |  
|Exercise of stock options                                                     |  | 1,328,092    |  |                                            | 2,450   |  |                    |   |   |       |   |         |   |  |   | 2,450   |  
|Employee stock purchase plan                                                  |  | 102,283      |  |                                            | 266     |  |                    |   |   |       |   |         |   |  |   | 266     |  
|Stock-based compensation                                                      |  |             |  |                                            | 6,721   |  |                    |   |   |       |   |         |   |  |   | 6,721   |  
|Net loss and comprehensive loss                                               |  |             |  |                                            |        |  |                    | (4 | ) |       |   | (13,026  | ) |  |   | (13,030 | )
|                                                                              |  |              |  |                                            |         |  |                    |    |   |       |   |          |   |  |   |         |  
|Balance at December 31, 2006                                                  |  | 94,335,027   |  |                                            | 843,026 |  |                    | (7 | ) |       |   | (750,341 | ) |  |   | 92,678  |  
|                                                                              |  |              |  |                                            |         |  |                    |    |   |       |   |          |   |  |   |         |  
|Exercise of stock options                                                     |  | 1,869,075    |  |                                            | 4,142   |  |                    |   |   |       |   |         |   |  |   | 4,142   |  
|Employee stock purchase plan                                                  |  | 92,585       |  |                                            | 224     |  |                    |   |   |       |   |         |   |  |   | 224     |  
|Stock-based compensation                                                      |  |             |  |                                            | 8,801   |  |                    |   |   |       |   |         |   |  |   | 8,801   |  
|Net loss and comprehensive income (loss)                                      |  |             |  |                                            |        |  |                    | 34 |   |       |   | (11,511  | ) |  |   | (11,477 | )
|                                                                              |  |              |  |                                            |         |  |                    |    |   |       |   |          |   |  |   |         |  
|Balance at December 30, 2007                                                  |  | 96,296,687   |  | $                                          | 856,193 |  | $                  | 27 |   |       | $ | (761,852 | ) |  | $ | 94,368  |  
|                                                                              |  |              |  |                                            |         |  |                    |    |   |       |   |          |   |  |   |         |  

See accompanying notes to consolidated financial statements.



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DRUGSTORE.COM, INC.

CONSOLIDATED STATEMENTS OF CASH FLOWS

(in thousands)



|                                                                                          |  |                    |         |   |                  |   |         |                |  |   |         |  
|----------------------------------------------------------------------------------------- |  | ------------------ | ------- | - | ---------------- | - | ------- | -------------- |  | - | ------- | -
|                                                                                          |  | For the year ended |        
|                                                                                          |  | December 30,2007   |         |   | December 31,2006 |   |         | January 1,2006 | 
|Operating Activities:                                                                     |  |                    |         |   |                  |   |         |                |  |   |         |  
|Net loss                                                                                  |  | $                  | (11,511 | ) |                  | $ | (13,026 | )              |  | $ | (20,899 | )
|Adjustments to reconcile net loss to net cash provided by (used in) operating activities: |  |                    |         |   |                  |   |         |                |  |   |         |  
|Depreciation                                                                              |  |                    | 7,504   |   |                  |   | 6,040   |                |  |   | 5,280   |  
|Amortization of marketing and sales agreements                                            |  |                    | 2,290   |   |                  |   | 2,290   |                |  |   | 2,290   |  
|Amortization of intangible assets                                                         |  |                    | 1,234   |   |                  |   | 2,060   |                |  |   | 3,004   |  
|Stock-based compensation                                                                  |  |                    | 8,801   |   |                  |   | 6,721   |                |  |   | 1,968   |  
|Loss on disposal of assets and other                                                      |  |                    | 14      |   |                  |   | 24      |                |  |   | 708     |  
|Changes in:                                                                               |  |                    |         |   |                  |   |         |                |  |   |         |  
|Accounts receivable                                                                       |  |                    | (1,375  | ) |                  |   | (2,474  | )              |  |   | 1,130   |  
|Inventories                                                                               |  |                    | (5,032  | ) |                  |   | (3,001  | )              |  |   | (4,181  | )
|Prepaid marketing expenses and other                                                      |  |                    | (929    | ) |                  |   | 5       |                |  |   | 162     |  
|Accounts payable, accrued expenses and other liabilities                                  |  |                    | 6,782   |   |                  |   | 278     |                |  |   | 735     |  
|                                                                                          |  |                    |         |   |                  |   |         |                |  |   |         |  
|Net cash provided by (used in) operating activities                                       |  |                    | 7,778   |   |                  |   | (1,083  | )              |  |   | (9,803  | )
|Investing Activities:                                                                     |  |                    |         |   |                  |   |         |                |  |   |         |  
|Purchases of marketable securities                                                        |  |                    | (27,544 | ) |                  |   | (22,853 | )              |  |   | (37,872 | )
|Sales and maturities of marketable securities                                             |  |                    | 37,141  |   |                  |   | 21,775  |                |  |   | 30,425  |  
|Purchases of fixed assets                                                                 |  |                    | (14,249 | ) |                  |   | (7,564  | )              |  |   | (6,034  | )
|Purchases of intangible assets                                                            |  |                    | (456    | ) |                  |   |        |                |  |   |        |  
|                                                                                          |  |                    |         |   |                  |   |         |                |  |   |         |  
|Net cash used in investing activities                                                     |  |                    | (5,108  | ) |                  |   | (8,642  | )              |  |   | (13,481 | )
|Financing Activities:                                                                     |  |                    |         |   |                  |   |         |                |  |   |         |  
|Proceeds from exercise of stock options and employee stock purchase plan                  |  |                    | 4,366   |   |                  |   | 2,716   |                |  |   | 2,091   |  
|Proceeds from private placement, net                                                      |  |                    |        |   |                  |   |        |                |  |   | 25,952  |  
|Proceeds from term loan, line of credit and asset financings                              |  |                    | 4,000   |   |                  |   | 2,325   |                |  |   | 1,662   |  
|Principal payments on capital leases, line of credit and term loan obligations            |  |                    | (5,857  | ) |                  |   | (2,214  | )              |  |   | (1,621  | )
|                                                                                          |  |                    |         |   |                  |   |         |                |  |   |         |  
|Net cash provided by financing activities                                                 |  |                    | 2,509   |   |                  |   | 2,827   |                |  |   | 28,084  |  
|                                                                                          |  |                    |         |   |                  |   |         |                |  |   |         |  
|Net increase (decrease) in cash and cash equivalents                                      |  |                    | 5,179   |   |                  |   | (6,898  | )              |  |   | 4,800   |  
|Cash and cash equivalents at beginning of year                                            |  |                    | 13,393  |   |                  |   | 20,291  |                |  |   | 15,491  |  
|                                                                                          |  |                    |         |   |                  |   |         |                |  |   |         |  
|Cash and cash equivalents at end of year                                                  |  | $                  | 18,572  |   |                  | $ | 13,393  |                |  | $ | 20,291  |  
|                                                                                          |  |                    |         |   |                  |   |         |                |  |   |         |  
|Supplemental Cash Flow Information:                                                       |  |                    |         |   |                  |   |         |                |  |   |         |  
|Cash paid for interest                                                                    |  | $                  | 402     |   |                  | $ | 398     |                |  | $ | 278     |  
|Equipment acquired in capital lease agreements                                            |  |                    | 469     |   |                  |   | 963     |                |  |   | 1,708   |  

See accompanying notes to consolidated financial statements.



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DRUGSTORE.COM, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

1. The Company and Summary of Significant Accounting Policies

The Company

drugstore.com, inc. is a leading online provider of health, beauty, vision, and pharmacy products. We
offer health, beauty, sexual well-being, household, and other non-prescription products and prescription medications through our website located at www.drugstore.com.We also offer prestige beauty products through our website located at
www.beauty.com (which is also accessible through the drugstore.com website); contact lenses through our wholly owned subsidiary International Vision Direct Corp. and its subsidiaries, collectively referred to as Vision Direct, through
websites located at www.visiondirect.com, www.lensmart.com, and www.lensquest.com (which are also accessible through the drugstore.com website); and customized nutritional supplement programs through our wholly owned subsidiary,
Custom Nutrition Services, Inc. (CNS). Our products are also available toll-free by telephone at 1-800-DRUGSTORE and 1-800-VISIONDIRECT. Under the terms of an agreement with Rite Aid Corporation, or Rite Aid, customers are also able to order refill
prescriptions for pickup at any Rite Aid store. We manage our business in four segments: over-the-counter (OTC), vision, mail-order pharmacy, and local pick-up pharmacy.

Principles of Consolidation and Basis of Presentation

The accompanying consolidated financial
statements include those of drugstore.com, inc. and our subsidiaries. All material intercompany transactions and balances have been eliminated.

We operate using a 52/53-week retail calendar year with each of the fiscal quarters in a 52-week year representing a 13-week period. Fiscal years 2007, 2006, and 2005 were 52-week years.

Estimates and Assumptions

The
preparation of financial statements in conformity with U.S. generally accepted accounting principles (GAAP) requires management to make estimates and assumptions that affect the amounts of assets and liabilities, revenues and expenses, and
disclosure of contingent assets and liabilities at the date of the financial statements. These estimates include, but are not limited to, revenue recognition, inventories, goodwill and intangible assets, stock-based compensation, deferred taxes, and
commitments and contingencies. Actual results could differ from our estimates, and these differences could be material.

Cash
Equivalents

We consider all highly liquid investments with a maturity of three months or less from the date of purchase to be cash
equivalents. Cash equivalents include money market funds and commercial paper.

Marketable Securities

Management determines the appropriate classification of marketable securities at the time of purchase and reevaluates such designation as of each balance
sheet date. The evaluation includes our view that our investments in debt securities are available to support current operations and therefore classified as a current asset. At December 30, 2007 and December 31, 2006, marketable
securities, which are considered available-for-sale, consisted primarily of commercial paper, corporate notes, and government bonds. At December 31, 2006, marketable securities also consisted of auction rate securities. Marketable securities
are carried at fair value. Net unrealized holding gains were $34,000 at December 30, 2007 and $13,000 at December 31, 2006. Cost of securities sold is determined using the specific identification method.



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DRUGSTORE.COM, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



We regularly monitor and evaluate the realizable value of our marketable securities. When assessing
marketable securities for other-than-temporary declines in value, we consider such factors as, among other things, how significant the decline in value is as a percentage of the original cost, how long the market value of the investment has been
less than its original cost, the performance of the issuers stock price in relation to the stock price of its competitors within the industry and the market in general, analyst recommendations, any news that has been released specific to the
issuer, and the outlook for the overall industry in which the issuer operates. If events and circumstances indicate that a decline in the value of these assets has occurred and is other than temporary, we record a charge against net earnings. No
such charges have been recorded in fiscal years 2007, 2006, and 2005.

Financial Instruments

Financial instruments consist of cash and cash equivalents, marketable securities, accounts receivable, accounts payable, term loans, line of credit, and
capital lease obligations. Due to their short-term nature, we believe the fair value of all financial instruments approximates the carrying amount based on the current rate offered for similar instruments.

Concentration of Credit Risk

Financial instruments, which potentially subject us to concentrations of credit risk, consist principally of our holdings of cash, cash equivalents, marketable securities, and accounts receivable. Our credit risk is managed by investing our
cash and marketable securities in high-quality money market instruments and securities of the U.S. government agencies, and high-quality corporate issuers. Our credit risk is managed through monitoring the stability of the United States-based
financial institutions we use and the diversification of our financial resources by limiting the investment in any one issuer of not more than 10% of the total portfolio at the time of purchase, except for investments in U.S. treasuries and agencies
and investment advisors money market funds.

Sales subject to reimbursements collected from insurance companies, pharmacy benefit
managers (PBMs), and managed care organizations through our relationship with Rite Aid currently represent 99% of our local pick-up pharmacy sales and 26% of our mail-order pharmacy sales.

Accounts Receivable

Accounts
receivable consists primarily of the net amounts to be collected from third parties, including amounts due from Rite Aid for co-payment and insurance reimbursement payments collected on our behalf, amounts collectible related to credit card
purchases, vendor volume purchase and rebate allowances, amounts collectible from advertising agreements, OTC fulfillment fees related to our agreement with Weil, and product revenue generated through our merchant agreement with Amazon.com, Inc.
(Amazon.com). As of December 30, 2007 and December 31, 2006, accounts receivable included $30.1 million and $29.6 million, respectively, of amounts being collected by Rite Aid on our behalf. Accounts receivable are recorded net of
allowances for doubtful accounts, which were $41,000 as of December 30, 2007 and $38,000 as of December 31, 2006. We determine our allowance for doubtful accounts by considering a number of factors, including the length of time receivables
are past due, previous loss history, our ability to offset our obligations, and the customers ability to pay its obligation. We write off accounts receivable when they become uncollectible, and any payments subsequently received are applied to
the allowance for doubtful accounts.

Inventories

Inventories consist of finished goods and are stated at the lower of cost (using the weighted average cost method) or the current estimated market value
and adjusted for shrinkage, slow moving, damaged, and expired



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DRUGSTORE.COM, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



inventory. We currently purchase our non-pharmaceutical inventory directly from manufacturers and distributors. Through our agreement with Rite Aid, we are
required to purchase all pharmaceutical inventory through Rite Aid unless we are able to obtain better overall terms from another vendor.

Fixed Assets

Fixed assets are stated at cost less accumulated depreciation and amortization, which includes the
depreciation of assets recorded under capital leases. Depreciation and amortization is determined using the straight-line method over the estimated useful lives of the related assets, which range from two to ten years. Fixed assets purchased under
capital leases and leasehold improvements are depreciated over the shorter of the lease term or the estimated useful life.

Included in
fixed assets is the cost of internally developed software and website development, including software used to upgrade and enhance our websites. We expense all costs related to the internally developed software other than those incurred during the
application development stage. Costs incurred during the application development stage are capitalized and amortized over the estimated useful life of the software, generally three years. Internal labor costs, including benefit costs, and
third-party consulting costs totaling $10.8 million, $3.5 million, and $2.8 million were capitalized during the fiscal years ended December 30, 2007, December 31, 2006, and January 1, 2006, respectively.

Leases

We categorize leases
at their inception as either operating or capital leases depending on certain defined criteria. We recognize operating lease costs on a straight-line basis without regard to deferred payment terms and lease incentives are treated as a reduction of
our costs over the term of the agreement.

Other Intangible Assets

Other intangible assets consist of assets acquired in connection with agreements between
drugstore.com and Rite Aid and General Nutrition Corporation (GNC). We also acquired certain other intangible assets in connection with the purchase of Beauty.com, Inc. (Beauty.com), CNS, and Vision Direct, including trade names, domain names, and
customer lists. In 2007, we acquired for $456,000 certain trademarks and intangibles associated with our new, private label de-luxeTMbrand of
natural, spa quality personal care products. All definite-lived intangible assets are being amortized over their expected useful lives, which range from two to ten years.

Goodwill

We test for impairment of goodwill during the fourth quarter and whenever indicators
of impairment occur. The first phase of the test screens for impairment, while the second phase of the test (if necessary) measures the amount of impairment. The first phase is performed by comparing the implied fair value of the applicable
reporting unit to its carrying value. Fair value is determined using either a discounted cash flow methodology or methodology based on comparable market prices. The second step of the goodwill impairment test compares the implied fair value of
reporting unit goodwill with the carrying amount of that goodwill. If the carrying amount of the reporting unit goodwill exceeds the implied fair value of that goodwill, an impairment loss is recognized in an amount equal to the excess.

During fiscal years 2007, 2006, and 2005, we performed our annual goodwill impairment review and determined that the fair value of each of our
reporting units was greater than the carrying value and, accordingly, no impairment charges were recorded.



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DRUGSTORE.COM, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



Long-Lived Assets

We review the carrying values of our amortized long-lived assets, including definite-lived intangible assets, whenever an indicator of impairment exists.
When facts and circumstances indicate that the carrying values of long-lived assets may be impaired, we perform an evaluation of recoverability. The determination of whether impairment exists is based on any excess of the carrying value over the
expected future cash flows, as estimated through undiscounted cash flows, excluding interest charges. Any resulting impairment charge would be measured based on the difference between the carrying value of the asset and its fair value, as estimated
through expected future discounted cash flows, discounted at a rate of return for an alternate investment.

We review our indefinite-lived
intangible assets, other than goodwill, for impairment annually during the fourth quarter or when an indicator of impairment exists. We compare the carrying value of the asset to its estimated fair value and record an impairment charge when the
carrying value of the asset exceeds the estimated fair value.

Net Sales

We recognize revenues in accordance with SEC Staff Accounting Bulletin No. 104, Revenue Recognition.We recognize revenue when the following
revenue recognition criteria are met: (1) persuasive evidence of an arrangement exists; (2) delivery has occurred or services have been rendered; (3) the selling price or fee earned is fixed or determinable; and (4) collection of
the resulting receivable is reasonably assured.

OTC ̧ Vision, and Mail-Order.We record revenues from sales of OTC, vision,
and mail-order pharmacy when the products are shipped and title passes to customers, net of promotional discounts, cancellations, rebates, and returns allowances. We generally require payment by credit card at the point of sale. We estimate return
allowances, which reduce product sales by our estimate of expected product returns, based on our historical experience. Historically, product returns have not been significant and have not differed significantly from our estimates.

From time to time, we provide incentive offers to our customers to encourage purchases. Such offers include discounts on specific current purchases, or
future rebates based on a percentage of the current purchase, as well as other offers. We treat discounts, when our customers accept them, as a reduction in the sales price of the related transaction and we present them as a net amount in net sales.
We treat rebates as a reduction in the sales price based on estimated redemption rates. We estimate redemption rates using our historical experience for similar offers. Historically, our redemption rates have not differed materially from our
estimates, which we adjust quarterly.

We also evaluate the criteria of Emerging Issues Task Force Issue No. 99-19, Reporting
Revenue Gross as a Principal Versus Net as an Agent, or EITF 99-19. Generally, when we are the primary party obligated in a transaction, are subject to inventory risk, have latitude in establishing prices and selecting suppliers, or have several
but not all of these indicators, we record revenue on a gross basis. If we are not primarily obligated and amounts earned are determined using a fixed percentage, a fixed-payment schedule, or a combination of the two, we record revenue on a net
basis. We record revenues generated by the GNC agreement in our OTC segment on a net basis because we do not take title to the inventory and do not establish pricing. We record revenues generated by the Weil agreement in our OTC segment on a net
basis, because we act as an agent, based on the fact that we earn a fixed dollar amount per customer transaction regardless of the amount billed to the customer, and we do not bear general inventory risk associated with these sales We record
revenues generated from the Amazon.com agreement in our OTC segment on a gross basis, because we act as a principal, based on the fact that we are subject to inventory risk, have latitude in establishing prices and selecting suppliers. Prior to this



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NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



agreement, effective November 9, 2005, we terminated a separate fulfillment agreement with Amazon.com. Under the terminated agreement, we recorded
fulfillment fees and revenues on a gross basis, because we acted as a principal and bore general inventory risk. We record revenues generated from our drop-ship arrangements with vendors agreement in our OTC segment on a gross basis when we are the
primary party obligated in a transaction, are subject to inventory risk, have latitude in establishing prices and selecting suppliers, or have several but not all of these indicators.

We also evaluate the criteria of Emerging Issues Task Force Issue No. 00-21, Revenue Arrangements with Multiple Deliverables, or EITF 00-21, when
we enter into arrangements with multiple deliverables. EITF 00-21 establishes three criteria that must be met in order for the deliverables in the arrangement to be treated as separate units of accounting; (1) the delivered item has value on a
stand-alone basis; (2) there is objective and reliable evidence of the fair value of the undelivered item; and (3) delivery or performance of the undelivered item is considered probable and substantially in the control of the vendor. When
the separation criteria are not met, the delivered item is accounted for as a combined unit of accounting with the undelivered item. Therefore, revenue for the delivered and undelivered items are recognized over the service period of the last
delivered item or if it is not a service, when the last item is delivered.

Prescription Sales.For insured prescriptions in both
our local pick-up and mail-order segments, the co-payment and the insurance reimbursement (which together make up the amount due to drugstore.com) constitute the full value of the prescription drug sale, and we receive this entire amount as cash. We
therefore recognize the entire amount as revenue when we ship the order to the customer (for mail order prescriptions) or when the customer picks up the order (for local pick-up prescriptions).

Local Pick-up.We recognize revenues from sales of prescription products ordered online or by telephone through the drugstore.com web store or the
RiteAid.com web store (which is powered by the drugstore.com web store) for pick-up at a Rite Aid store, including co-payments that Rite Aid receives and collects on our behalf when the customer picks up the product. In these circumstances, we use
Rite Aid as our fulfillment partner. We record revenues in our local pick-up pharmacy segment on a gross basis, because we act as a principal, based on the fact that, among other things, we bear both inventory risk and credit and collection risk
associated with these sales.

Cost of Sales

Cost of sales consists primarily of the cost of products sold to our customers, including allowances for shrinkage and damaged, slow-moving, and expired inventory, outbound and inbound shipping costs, and expenses
related to promotional inventory included in shipments to customers. Payments that we receive from vendors in connection with volume purchase or rebate allowances and payment discount terms are netted against cost of sales.

Shipping Activities

Our
revenues from shipping charges to customers are included in net sales and were $15.4 million, $13.6 million, and $11.1 million for the years ended December 30, 2007, December 31, 2006, and January 1, 2006. Outbound shipping costs
are included in cost of sales and were $24.8 million, $21.9 million, and $21.4 million for the years ended December 30, 2007, December 31, 2006, and January 1, 2006. The net cost to us of shipping activities was $9.4 million,
$8.3 million, and $10.3 million for the years ended December 30, 2007, December 31, 2006, and January 1, 2006.



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DRUGSTORE.COM, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



Fulfillment and Order Processing

Fulfillment and order processing expenses include payroll and related expenses for personnel engaged in purchasing, fulfillment, distribution, and
customer care activities (including warehouse personnel and pharmacists engaged in prescription verification activities), distribution center equipment and packaging supplies, per-unit fulfillment fees charged by Rite Aid for prescriptions ordered
through the drugstore.com website and picked up at a Rite Aid store, drop-ship processing fees, credit card processing fees, and bad debt expenses. These expenses also include rent and depreciation related to equipment and fixtures in our
distribution center and call center facilities.

Marketing and Sales

Marketing and sales expenses include advertising expenses, promotional expenditures and payroll and related expenses for personnel engaged in marketing
and merchandising activities.

Advertising costs are expensed as incurred. Costs associated with our brand advertising and personalization
initiatives, which concluded in the first quarter of 2006, public relations, advertising, and trade shows, are expensed when the related services are rendered. Our marketing contracts that span a longer period of time, including Web portal marketing
agreements and the costs associated with our Rite Aid agreement, are amortized on a straight-line basis over the period of each contract. Advertising expense for the years ended December 30, 2007, December 31, 2006, and
January 1, 2006 was $23.0 million, $21.0 million, and $25.6 million, respectively.

Technology and Content

Technology and content expenses consist primarily of payroll and related expenses for personnel engaged in developing, maintaining, and making routine
upgrades and enhancements to our websites. Technology and content expenses also include Internet access and hosting charges, depreciation on hardware and IT structures, utilities, and website content and design expenses.

Technology and content costs are expensed as incurred, except for certain costs relating to the development of internal-use software and website
development, including upgrades and enhancements to our websites, which are capitalized and depreciated over their estimated useful life.

General and Administrative

General and administrative expenses consist of payroll and related expenses for executive
and administrative personnel, corporate facility expenses, professional service expenses, and other general corporate expenses.

Interest Income and Expense

Interest income consists of earnings on our cash, cash equivalents, and marketable
securities, and interest expense consists primarily of interest associated with capital leases and debt obligations. Interest income for the years ended December 30, 2007, December 31, 2006, and January 1, 2006 totaled $2.1
million, $2.1 million, and $1.6 million, respectively. Interest expense was $0.4 million, $0.4 million, and $0.3 million for the years ended December 30, 2007, December 31, 2006, and January 1, 2006, respectively.

Accumulated Other Comprehensive Income/Loss

Accumulated other comprehensive income/loss consists of the accumulated net unrealized gains and losses on available-for-sale securities (see note 3) and cumulative translation adjustments from the translation of
assets



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DRUGSTORE.COM, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



and liabilities of our Canadian subsidiary into U.S. dollars. Our currency translation adjustment was an unrealized gain of $6,000 as of December 30,
2007 and an unrealized loss of $20,000 as of December 31, 2006.

Income Taxes

We account for income taxes under the liability method. Under the liability method, deferred tax assets and liabilities are determined based on
differences between the financial reporting and tax basis of assets and liabilities and are measured using the enacted tax rates and laws that are expected to be in effect when the differences are expected to be recovered. Valuation allowances are
established, when necessary, to reduce deferred tax assets to the amounts expected to be realized.

Effective January 1, 2007,
we adopted the provisions of Financial Accounting Standards Board (FASB) Interpretation No. 48, Accounting for Uncertainty in Income Taxesan Interpretation of FASB Statement No. 109 (FIN 48).FIN 48 contains a two-step approach to recognizing and measuring uncertain tax positions (tax contingencies) accounted for in accordance with SFAS No. 109. The first step is to evaluate the tax position for recognition by determining
if the weight of available evidence indicates it is more likely than not that the position will be sustained on audit, including resolution of related appeals or litigation processes, if any. The second step is to measure the tax benefit as the
largest amount which is more than 50% likely of being realized upon ultimate settlement. We consider many factors when evaluating and estimating our tax positions and tax benefits, which may require periodic adjustments and which may not
accurately forecast actual outcomes. We did not have any unrecognized tax benefits before or after the adoption of FIN 48. Our policy is to recognize interest and penalties related to the underpayment of income taxes as a component of income tax
expense. To date, we have not incurred charges for interest or penalties in relation to the underpayment of income taxes. The tax years 1998 through the present remain open to examination by the major taxing jurisdictions to which we are subject.

Stock-Based Compensation

Change in Accounting Principle

On January 2, 2006, the first day of our fiscal year 2006, we
adopted FASB Statement No. 123 (revised 2004), Share-Based Payment(FAS 123(R)), which requires the measurement and recognition of compensation expense for all stock-based awards based on estimated fair values. Pro forma disclosure is no
longer an alternative to financial statement recognition. We elected to use the modified prospective transition method as permitted by FAS 123(R) and therefore have not restated our financial results for prior periods. Under this transition
method, the post adoption stock-based compensation expense also includes expense for all stock-based awards granted prior to, but not yet vested as of January 2, 2006, the estimated fair values of which were established on the grant dates in
accordance with the original provisions of FASB Statement No. 123, Accounting for Stock-Based Compensation (FAS 123). FAS 123(R) supersedes previous accounting under Accounting Principles Board Opinion No. 25, Accounting for
Stock Issued to Employees (APB 25), and also amends FASB Statement No. 95, Statement of Cash Flows. In March 2005, the Securities and Exchange Commission (SEC) issued Staff Accounting Bulletin No. 107 (SAB 107) providing
supplemental implementation guidance for FAS 123(R). We have applied the provisions of SAB No. 107 in our adoption of FAS 123(R). In November 2005, the FASB issued FASB Staff Position No. 123(R)-3, Transition Election Related to
Accounting for the Tax Effects of Share-Based Payment Awards.We have adopted the simplified method to calculate the beginning balance of the additional paid-in-capital (APIC) pool of excess tax benefit, and to determine the subsequent effect on
the APIC pool and the Consolidated Statements of Cash Flows of the tax effects of stock-based compensation awards that were outstanding upon our adoption of FAS 123(R). Our fiscal year 2007 and 2006 financial results reflect the impact of FAS
123(R).



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DRUGSTORE.COM, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



Prior to the adoption, we accounted for our stock-based awards to employees and directors using the
intrinsic value method in accordance with APB 25 as allowed under FAS 123. Under the intrinsic value method, no compensation expense was recognized when the exercise price of employee stock options equaled the fair value of the underlying stock on
the date of grant. Deferred stock-based compensation was recorded for those situations where the exercise price of an option was lower than the fair value for financial reporting purposes of the underlying common stock on the date of grant.

Under the modified-prospective-transition method, compensation cost recognized in 2006 includes: (a) compensation cost for all
share-based payments granted prior to, but not yet vested as of January 2, 2006, which is based on the grant date fair value estimated in accordance with the original provisions of FAS 123, recognized over the vesting period of the underlying
options using the multiple-option approach, (b) compensation cost for all share-based payments granted subsequent to January 2, 2006, which is based on the grant-date fair value estimated in accordance with the provisions of FAS 123(R),
recognized over the requisite service period of the award on a straight-line basis, and (c) compensation cost for shares issued under the 1999 employee stock purchase plan, which is based on the fair value estimated in accordance with the
provisions of FAS 123(R). In accordance with the modified-prospective-transition method, results for the year ended January 1, 2006 have not been restated to reflect, and do not include, the impact of FAS 123(R).

The following table summarizes the effect of adopting FAS 123(R) as of January 2, 2006 (in thousands, except for per share data):



|                                                 |  |                            |      
|------------------------------------------------ |  | -------------------------- | -----
|                                                 |  | Year EndedDecember 31,2006
|Stock-based compensation expense recognized:     |  |                            |      
|Fulfillment and order processing                 |  | $                          | 835  
|Marketing and sales                              |  |                            | 1,058
|Technology and content                           |  |                            | 1,071
|General and administrative(1)                    |  |                            | 2,874
|                                                 |  |                            |      
|Increase in pre-tax and net loss                 |  | $                          | 5,838
|                                                 |  |                            |      
|Increase in basic and diluted net loss per share |  | $                          | 0.06 
|                                                 |  |                            |      



|(1) | Stock-based compensation, which would have been recognized under
APB 25, excludes $883,000 for options granted with exercise prices below market value on the date of grant prior to the adoption of FAS 123(R).
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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The following pro-forma information is presented for comparative purposes and illustrates the effect
on net loss and loss per common share for the period presented as if we had applied the fair value recognition provisions of FAS 123 to options granted under our 1998 Stock Plan and our 1999 ESPP prior to January 2, 2006 (in thousands, except
share and per share data):



|                                                                                         |  |                          |         |  
|---------------------------------------------------------------------------------------- |  | ------------------------ | ------- | -
|                                                                                         |  | Year endedJanuary 1,2006 |        
|Net loss, as reported                                                                    |  | $                        | (20,899 | )
|Add: Stock-based compensation, as reported                                               |  |                          | 1,968   |  
|Deduct: Total stock-based compensation determined under fair value method for all awards |  |                          | (8,947  | )
|                                                                                         |  |                          |         |  
|Net lossFAS 123 adjusted                                                                |  | $                        | (27,878 | )
|                                                                                         |  |                          |         |  
|Basic and diluted net loss per shareas reported                                         |  | $                        | (0.23   | )
|                                                                                         |  |                          |         |  
|Basic and diluted net loss per shareFAS 123 adjusted                                    |  | $                        | (0.31   | )
|                                                                                         |  |                          |         |  

Net Loss per Share

Net loss per share is computed using the weighted average number of shares of common stock outstanding. Shares associated with stock options, warrants,
and our employee stock purchase plan are not included in the calculation of diluted net loss per share as their effects are antidilutive.

The following table sets forth the computation of basic and diluted net loss per share for the periods indicated:



|                                                                                    |  |                                                 |            |   |                  |   |            |                |  |   |            |  
|----------------------------------------------------------------------------------- |  | ----------------------------------------------- | ---------- | - | ---------------- | - | ---------- | -------------- |  | - | ---------- | -
|                                                                                    |  | Year Ended                                      |           
|                                                                                    |  | December 30,2007                                |            |   | December 31,2006 |   |            | January 1,2006 | 
|                                                                                    |  | (in thousands, except share and per share data) |           
|Numerator:                                                                          |  |                                                 |            |   |                  |   |            |                |  |   |            |  
|Net loss                                                                            |  | $                                               | (11,511    | ) |                  | $ | (13,026    | )              |  | $ | (20,899    | )
|                                                                                    |  |                                                 |            |   |                  |   |            |                |  |   |            |  
|Denominator:                                                                        |  |                                                 |            |   |                  |   |            |                |  |   |            |  
|Weighted average common shares used to compute basic and diluted net loss per share |  |                                                 | 95,350,046 |   |                  |   | 93,405,405 |                |  |   | 90,808,817 |  
|                                                                                    |  |                                                 |            |   |                  |   |            |                |  |   |            |  
|Basic and diluted net loss per share                                                |  | $                                               | (0.12      | ) |                  | $ | (0.14      | )              |  | $ | (0.23      | )
|                                                                                    |  |                                                 |            |   |                  |   |            |                |  |   |            |  

At December 30, 2007, December 31, 2006, and January 1, 2006 there were
16,742,458, 18,995,824, and 15,764,528 shares, respectively, of common stock subject to stock options. At December 30, 2007, December 31, 2006, and January 1, 2006 there were 865,000, 615,000, and 615,000 shares, respectively, of
common stock subject to warrants. These shares were excluded from the computation of diluted net loss per share as their effect was antidilutive. If we had reported net income, the calculation of diluted net loss per share would have included the
dilutive effect of these common stock equivalents using the treasury stock method.

New Accounting Pronouncements

In December 2007, the FASB issued SFAS No. 141 (R), Business Combinations, and SFAS No. 160, Noncontrolling Interests in
Consolidated Financial Statements. SFAS No. 141 (R) requires an acquirer to



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measure the identifiable assets acquired, the liabilities assumed and any noncontrolling interest in the acquiree at their fair values on the acquisition
date, with goodwill being the excess value over the net identifiable assets acquired. SFAS No. 160 clarifies that a noncontrolling interest in a subsidiary should be reported as equity in the consolidated financial statements. The calculation
of earnings per share will continue to be based on income amounts attributable to the parent. SFAS No. 141 (R) and SFAS No. 160 are effective for financial statements issued for fiscal years beginning after December 15, 2008.
Early adoption is prohibited. We do not anticipate that the adoption of SFAS No. 141 (R) or SFAS No. 160 will currently have a material impact on our consolidated financial statements but will impact any business combination beginning
in 2009.

In February 2007, the FASB issued Statement of Financial Accounting Standards (SFAS) No. 159, The Fair Value Option
for Financial Assets and Liabilities(SFAS 159). SFAS 159 will become effective as of the beginning of the first fiscal year beginning after November 15, 2007. SFAS 159 provides companies with an option to report selected financial assets
and liabilities at fair value that are not currently required to be measured at fair value. Accordingly, companies would then be required to report unrealized gains and losses on these items in earnings at each subsequent reporting date. The
objective is to improve financial reporting by providing companies with the opportunity to mitigate volatility in reported earnings caused by measuring related assets and liabilities differently. SFAS 159 also establishes presentation and disclosure
requirements designed to facilitate comparisons between companies that choose different measurement attributes for similar types of assets and liabilities. The adoption of SFAS 159 in our first fiscal quarter of 2008, did not have a material impact
on our consolidated financial statements as we did not elect the fair value option for any financial assets or liabilities.

In September
2006, the FASB issued SFAS No. 157, Fair Value Measurements(SFAS 157). SFAS 157 defines fair value, establishes a framework for measuring fair value under GAAP, and expands disclosures about fair value measurements. SFAS 157 emphasizes
that fair value is a market-based measurement, not an entity-specific measurement, and states that a fair value measurement should be determined based on the assumptions that market participants would use in pricing the asset or liability. In
February 2007, the FASB issued SFAS 157-2, which delayed the effective date of SFAS 157 to fiscal years beginning after November 15, 2008 for certain non-financial assets and liabilities. We do not anticipate that the adoption of SFAS 157 in
the first quarter for financial assets and liabilities or in 2009 for the remaining assets and liabilities will have a material impact on our consolidated financial statements.

2. Strategic Agreements

Agreements with Rite Aid

In June 1999, we entered into a ten-year strategic relationship with Rite Aid. Through our agreements with Rite Aid, which expire in 2009, we have access
to Rite Aid customers through the RiteAid.com website, which is powered by the drugstore.com website. All pharmacy orders processed through the drugstore.com website or the RiteAid.com website can either be shipped to the customer from our
distribution center or, in the case of refills of existing drugstore.com or Rite Aid prescriptions, picked up by the customer at any Rite Aid store. Rite Aid adjudicates and collects insurance reimbursement payments on our behalf.

In addition to providing for multi-channel delivery options, Rite Aid and drugstore.com agreed to promote each others services both
online and in other promotional materials. As part of this relationship, we agreed to certain exclusivity provisions that limit our ability to promote, or affiliate with, any other brick-and-mortar retail drugstore or to operate as a traditional
brick-and-mortar drugstore, and Rite Aid agreed not to offer or sell products or services on the Internet other than through our website.



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We are required to purchase our pharmaceutical inventory through Rite Aid, unless we are able to
obtain better overall terms from another vendor. This arrangement enables us to take advantage of Rite Aids volume discounts and favorable credit terms. To date, we have not been able to obtain more favorable overall terms from any other
supplier, and we currently expect that we will continue to purchase our pharmaceutical products inventory through Rite Aid. As a result of this agreement, Rite Aid is one of our largest suppliers. We also benefit from access to many of Rite
Aids relationships with insurance companies and PBMs, which enables us to meet the needs of more customers because of the availability of insurance coverage to those customers.

We license Rite Aid information technology and pharmacy systems, which we currently use to adjudicate and process local pharmacy orders.

A portion of the non-cash consideration relating to our agreements with Rite Aid has been allocated to advertising commitments and classified within
prepaid marketing expenses. The assets are being amortized on a straight-line basis over their contractual life of 10 years, ending in 2009. Amortization expense of $2.3 million is included in marketing and sales expense for each of the fiscal years
2007, 2006, and 2005.

Agreement with GNC

We have a 10-year agreement with GNC under which we are an online provider of GNC-branded products. We had the exclusive right to sell GNCs wellness products over the Internet until July 2005, at which time our
exclusivity provisions terminated. For the remainder of the agreement, which ends in 2009, we have the nonexclusive right to sell these products. As part of this relationship, we created the GNC Store within the drugstore.com website, which is
dedicated to selling GNC products on a consignment basis. We retain a percentage of the gross revenues that we collect from sales of GNC products and recognize only the net amount we retain as revenues. We have also agreed with GNC to co-promote
each others products and services in both traditional and online marketing efforts, including GNCs placement of a link to our website on the GNC website.

A portion of the non-cash consideration relating to the agreements with GNC has been allocated to vendor agreements and classified within other intangible assets. The assets are being amortized on a straight-line
basis over their contractual life of 10 years.

Agreements with Amazon.com

In September 2007, we entered into a three-year merchant agreement with Amazon.com to sell prestige beauty products through the Beauty.com marketplace on
the Amazon.com website. We ship the Amazon.com orders from our distribution facility in exchange for an agreed-upon product price less a referral fee. Product revenue generated by the merchant agreement and referral fees paid totaled $124,000 and
$20,000, respectively, in 2007.

In September 2003, we entered into an e-commerce agreement with Amazon.com. Under the e-commerce
agreement, we were a non-exclusive wholesaler and fulfillment provider for certain OTC products sold through the Health & Personal Care store on the Amazon.com website. We shipped the Amazon.com orders we fulfilled in Amazon.com-branded
boxes from our distribution facility, in exchange for a fulfillment fee and agreed-on product price. We began shipping orders under this agreement in December 2003 and we terminated this agreement on November 9, 2005. Neither party had any
material obligations following termination. The product revenue and fulfillment fees generated by our agreement with Amazon.com totaled $6.3 million in 2005.



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We also have a technology license and advertising agreement with Amazon.com, under which we have the
right to license substantially all of Amazon.coms technology for use in our business and to receive certain technological and advertising support from Amazon.com, and Amazon.com has the right to license substantially all of our technology for
use in its business. Neither party may use the others technology to compete against the other. Currently, neither party has licensed any technology from the other under this agreement. If we were to be acquired by a competitor of Amazon.com
and Amazon.com did not vote in favor of the transaction, we would lose our rights to use Amazon.coms technology, if we are then using any. This agreement also restricts us from promoting on our website any company, other than drugstore.com,
that sells products or services competitive with those that Amazon.com offers or is preparing to produce or market. This agreement, which we entered into in August 1998, has a 10-year term.

Agreement with Weil Lifestyle

On December 31, 2005, we entered into a fulfillment agreement with Weil. This agreement replaced our June 2003 agreement with Weils predecessor, whereby we and Weil developed a Weil-branded customized nutritional supplement
program and three web stores to sell products recommended by Weil. Under the new fulfillment agreement, Weil took over the development and maintenance of the websites, marketing, and other business operations for the program and web stores, and we
provide fulfillment and customer service operations in exchange for an agreed-on fulfillment fee. The revenue generated by our agreement with Weil totaled $1.7 million in 2007 and $2.0 million in 2006.

3. Cash, Cash Equivalents and Marketable Securities

Cash, cash equivalents, and marketable securities consist of the following:



|                                                       |  |                   |        |                             |   |                              |  |           |   |  |   |       
|------------------------------------------------------ |  | ----------------- | ------ | --------------------------- | - | ---------------------------- |  | --------- | - |  | - | ------
|                                                       |  | December 30, 2007
|                                                       |  | AmortizedCost     |        | GrossUnrealizedHoldingGains |   | GrossUnrealizedHoldingLosses |  | FairValue
|                                                       |  | (in thousands)   
|Cash                                                   |  | $                 | 17,675 |                             | $ |                             |  | $         |  |  | $ | 17,675
|Commercial paper                                       |  |                   | 897    |                             |   |                             |  |           |  |  |   | 897   
|                                                       |  |                   |        |                             |   |                              |  |           |   |  |   |       
|Cash and cash equivalents                              |  |                   | 18,572 |                             |   |                             |  |           |  |  |   | 18,572
|                                                       |  |                   |        |                             |   |                              |  |           |   |  |   |       
|Commercial paper                                       |  |                   | 1,791  |                             |   |                             |  |           |  |  |   | 1,791 
|U.S. government agency obligations                     |  |                   | 10,466 |                             |   | 7                            |  |           |  |  |   | 10,473
|Corporate notes and bonds                              |  |                   | 4,871  |                             |   | 20                           |  |           |  |  |   | 4,891 
|Private placement bonds                                |  |                   | 515    |                             |   | 7                            |  |           |  |  |   | 522   
|                                                       |  |                   |        |                             |   |                              |  |           |   |  |   |       
|Marketable securities                                  |  |                   | 17,643 |                             |   | 34                           |  |           |  |  |   | 17,677
|                                                       |  |                   |        |                             |   |                              |  |           |   |  |   |       
|Total cash, cash equivalents and marketable securities |  | $                 | 36,215 |                             | $ | 34                           |  | $         |  |  | $ | 36,249
|                                                       |  |                   |        |                             |   |                              |  |           |   |  |   |       



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|                                                       |  |                   |        |                             |   |                              |  |           |   |  |   |       
|------------------------------------------------------ |  | ----------------- | ------ | --------------------------- | - | ---------------------------- |  | --------- | - |  | - | ------
|                                                       |  | December 31, 2006
|                                                       |  | AmortizedCost     |        | GrossUnrealizedHoldingGains |   | GrossUnrealizedHoldingLosses |  | FairValue
|                                                       |  | (in thousands)   
|Cash                                                   |  | $                 | 6,208  |                             | $ |                             |  | $         |  |  | $ | 6,208 
|Commercial paper                                       |  |                   | 7,185  |                             |   |                             |  |           |  |  |   | 7,185 
|                                                       |  |                   |        |                             |   |                              |  |           |   |  |   |       
|Cash and cash equivalents                              |  |                   | 13,393 |                             |   |                             |  |           |  |  |   | 13,393
|                                                       |  |                   |        |                             |   |                              |  |           |   |  |   |       
|Auction rate securities                                |  |                   | 20,275 |                             |   |                             |  |           |  |  |   | 20,275
|U.S. government agency obligations                     |  |                   | 4,977  |                             |   | 9                            |  |           |  |  |   | 4,986 
|Corporate notes and bonds                              |  |                   | 1,981  |                             |   | 4                            |  |           |  |  |   | 1,985 
|                                                       |  |                   |        |                             |   |                              |  |           |   |  |   |       
|Marketable securities                                  |  |                   | 27,233 |                             |   | 13                           |  |           |  |  |   | 27,246
|                                                       |  |                   |        |                             |   |                              |  |           |   |  |   |       
|Total cash, cash equivalents and marketable securities |  | $                 | 40,626 |                             | $ | 13                           |  | $         |  |  | $ | 40,639
|                                                       |  |                   |        |                             |   |                              |  |           |   |  |   |       

The following table summarizes contractual maturities of our commercial paper and marketable
securities as of December 30, 2007:



|                                       |  |               |        |           |   |       
|-------------------------------------- |  | ------------- | ------ | --------- | - | ------
|                                       |  | AmortizedCost |        | FairValue
|Due within one year                    |  | $             | 16,035 |           | $ | 16,047
|Due after one year through three years |  |               | 2,505  |           |   | 2,527 
|                                       |  |               |        |           |   |       
|Total                                  |  | $             | 18,540 |           | $ | 18,574
|                                       |  |               |        |           |   |       

4. Fixed Assets

Fixed assets consist of the following:



|                                               |  |                  |         |   |                  |   |         |  
|---------------------------------------------- |  | ---------------- | ------- | - | ---------------- | - | ------- | -
|                                               |  | December 30,2007 |         |   | December 31,2006 |  
|                                               |  | (in thousands)   |        
|Computers and equipment                        |  | $                | 24,838  |   |                  | $ | 24,067  |  
|Purchased and internally developed software    |  |                  | 23,994  |   |                  |   | 16,161  |  
|Furniture and fixtures                         |  |                  | 3,127   |   |                  |   | 2,860   |  
|Leased assets                                  |  |                  | 7,187   |   |                  |   | 6,830   |  
|Leasehold improvements                         |  |                  | 10,898  |   |                  |   | 10,668  |  
|                                               |  |                  |         |   |                  |   |         |  
|                                               |  |                  | 70,044  |   |                  |   | 60,586  |  
|Less accumulated depreciation and amortization |  |                  | (51,211 | ) |                  |   | (43,642 | )
|                                               |  |                  |         |   |                  |   |         |  
|                                               |  |                  | 18,833  |   |                  |   | 16,944  |  
|Construction in progress                       |  |                  | 6,668   |   |                  |   | 1,349   |  
|                                               |  |                  |         |   |                  |   |         |  
|Total                                          |  | $                | 25,501  |   |                  | $ | 18,293  |  
|                                               |  |                  |         |   |                  |   |         |  

Accumulated amortization on leased assets was $5.4 million as of December 30, 2007 and $3.6
million as of December 31, 2006. Amortization is included in depreciation expense.



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5. Other Intangible Assets

The other intangible assets balances as of December 30, 2007 were as follows (in thousands):



|                                           |  |                                 |  |                     |        |                 |   |                         |  |   |            |   |  |   |      
|------------------------------------------ |  | ------------------------------- |  | ------------------- | ------ | --------------- | - | ----------------------- |  | - | ---------- | - |  | - | -----
|                                           |  | WeightedAverageYearsUseful Life |  | GrossCarryingAmount |        | Acquisitions(1) |   | AccumulatedAmortization |  |   | NetBalance
|Vision Direct trade name                   |  | indefinite                      |  | $                   | 2,700  |                 | $ |                        |  | $ |           |   |  | $ | 2,700
|Vision Direct customer base                |  | 3                               |  |                     | 1,931  |                 |   |                        |  |   | (1,931     | ) |  |   |     
|Vision Direct vendor agreement             |  | 2                               |  |                     | 1,434  |                 |   |                        |  |   | (1,434     | ) |  |   |     
|Vision Direct covenant of non-compete      |  | 2                               |  |                     | 575    |                 |   |                        |  |   | (575       | ) |  |   |     
|GNC vendor agreement                       |  | 10                              |  |                     | 12,265 |                 |   |                        |  |   | (11,149    | ) |  |   | 1,116
|CNS contract and technology assets         |  | 4                               |  |                     | 3,330  |                 |   |                        |  |   | (3,312     | ) |  |   | 18   
|Truescents trademark                       |  | indefinite                      |  |                     |       |                 |   | 252                     |  |   |           |   |  |   | 252  
|Technology license, domain names and other |  | 6                               |  |                     | 1,511  |                 |   | 204                     |  |   | (1,203     | ) |  |   | 512  
|                                           |  |                                 |  |                     |        |                 |   |                         |  |   |            |   |  |   |      
|Total other intangible assets              |  | 7                               |  | $                   | 23,746 |                 | $ | 456                     |  | $ | (19,604    | ) |  | $ | 4,598
|                                           |  |                                 |  |                     |        |                 |   |                         |  |   |            |   |  |   |      



|(1) | During 2007, we acquired for $456,000 certain trademarks and
intangibles associated with our new, private label de-luxe brand of natural, spa quality personal care products.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

The other intangible assets balances as of December 31, 2006 were as follows (in thousands):



|                                           |  |                                 |  |                     |        |     |                         |   |         |            |  |   |      
|------------------------------------------ |  | ------------------------------- |  | ------------------- | ------ | --- | ----------------------- | - | ------- | ---------- |  | - | -----
|                                           |  | WeightedAverageYearsUseful Life |  | GrossCarryingAmount |        |     | AccumulatedAmortization |   |         | NetBalance
|Vision Direct trade name                   |  | indefinite                      |  | $                   | 2,700  |     |                         | $ |        |            |  | $ | 2,700
|Vision Direct customer base                |  | 3                               |  |                     | 1,931  |     |                         |   | (1,931  | )          |  |   |     
|Vision Direct vendor agreement             |  | 2                               |  |                     | 1,434  |     |                         |   | (1,434  | )          |  |   |     
|Vision Direct covenant of non-compete      |  | 2                               |  |                     | 575    |     |                         |   | (575    | )          |  |   |     
|GNC vendor agreement                       |  | 10                              |  |                     | 12,265 |     |                         |   | (10,405 | )          |  |   | 1,860
|CNS contract and technology assets         |  | 4                               |  |                     | 3,330  |     |                         |   | (2,998  | )          |  |   | 332  
|Technology license, domain names and other |  | 6                               |  |                     | 1,511  | (2) |                         |   | (1,027  | )          |  |   | 484  
|                                           |  |                                 |  |                     |        |     |                         |   |         |            |  |   |      
|Total other intangible assets              |  | 7                               |  | $                   | 23,746 |     |                         | $ | (18,370 | )          |  | $ | 5,376
|                                           |  |                                 |  |                     |        |     |                         |   |         |            |  |   |      



|(2) | During 2006, we sold a domain name with a gross carrying value
and accumulated amortization value of $65,000 or a net book value of $0, and incurred patent costs totaling $9,000.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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The following table summarizes our estimated amortization expense for each of the next five fiscal
years (in thousands):



|            |  |   |      
|----------- |  | - | -----
|Fiscal year |  |   |      
|2008        |  | $ | 867  
|2009        |  |   | 451  
|2010        |  |   | 80   
|2011        |  |   | 80   
|2012        |  |   | 79   
|            |  |   |      
|Total       |  | $ | 1,557
|            |  |   |      

6. Goodwill

Goodwill in our OTC segment includes $2.7 million related to the acquisition of CNS in 2003 and $5.7 million related to our acquisition of Beauty.com in 2000. Goodwill in our vision segment includes $23.8 million
related to the acquisition of Vision Direct in 2003. There were no changes to goodwill in fiscal years 2007 or 2006.

7. Long-Term Obligations

Line of Credit and Term Loans

In December 2004, we entered into an amended and restated loan and security agreement with a bank. In January 2005, we borrowed $1.0 million on the line of credit and in December 2005, we converted the $1.0 million
line of credit into a term loan. The term loan totaled $361,000 and $694,000 as of December 30, 2007 and December 31, 2006, respectively, and is payable in 36 monthly installments of principal and interest at a rate of prime rate plus
0.50% (7.75% at December 30, 2007 and 8.75% at December 31, 2006). In addition, the agreement includes a $2.0 million term loan for capital equipment expenditures that accrues interest on the outstanding principal balance at a rate of
prime rate plus 0.50%. This term loan was payable in 36 equal monthly installments of principal, plus accrued interest, beginning on February 1, 2005 and ending on January 1, 2008. The balance outstanding under this term loan was $55,000
and $722,000 as December 30, 2007 and December 31, 2006, respectively. Our equipment, inventory, accounts receivable, cash, investments, and intangible assets collateralize the borrowings under the agreement. The agreement contains certain
financial and non-financial covenants with which we were in compliance at December 30, 2007.

In April 2007, we amended our amended
and restated loan and security agreement with our existing bank. The existing agreement includes a revolving line of credit allowing for borrowings of up to $10.0 million, which accrue interest at the prime rate (7.25% at December 31, 2007).
The revolving line of credit matures in March 2008. The agreement allows for the conversion of up to $2.5 million of the outstanding balance into a term loan within 60 days of maturity. For the year ended December 30, 2007, borrowings under the
existing line of credit totaled $4.0 million, of which $1.0 million was converted into a term loan in April 2007, $2.5 million was repaid and $1.5 million remains outstanding as of December 30, 2007. The term loan totaled $778,000 as of
December 30, 2007 and is payable in 36 monthly installments of principal and interest at a rate of prime rate plus 0.50% (7.75% at December 30, 2007)

Capital Leases

In October 2005, we entered into an agreement to lease computer equipment
under a non-cancelable capital lease. With respect to each draw under this lease, 63.5% of the sum of the draw amount plus interest determined



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NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



at the time of the draw was payable in monthly installments over the 24 months following the draw. At the end of the 24-month period, we had the option to
either pay the remaining 36.5% in a single balloon payment or extend financing for an additional 12 months. All draws under this lease, which were limited to $1.2 million, were completed by June 2006. We had drawn the entire $1.2 million under this
lease, payable in 24 monthly installments of $37,600 at an interest rate of 9.4%. As of December 30, 2007, we had paid off the lease, including the balloon payment. As of December 31, 2006, the amount due under the agreement was $789,000.

In July 2006, we entered into an agreement to finance equipment in our distribution center totaling $1.9 million under a non-cancelable
capital lease. The lease is payable in 36 monthly installments of approximately $60,000 beginning January 2007 and ending December 2009, and accrues interest at a rate of 8%. As of December 30, 2007 and December 31, 2006, the amount due
under the agreement was $1.3 million and $1.9 million, respectively.

We also lease computer equipment under non-cancelable capital leases.
Capital lease obligations bear interest at rates ranging from 7% to 8% and mature 21 to 60 months from the date of funding. We secured additional funds of $469,000 during 2007 and $373,000 during 2006, through capital lease financing agreements,
through which we financed certain computer equipment, software, fixtures, and equipment for periods of two and three years. We are in compliance with all covenants required by these agreements. These amounts are included in the table below within
the category of capital leases.

Maturities of long-term obligations at December 30, 2007 are as follows:



|                                              |  |                             |        |   |                |   |       |       |  |   |        |  
|--------------------------------------------- |  | --------------------------- | ------ | - | -------------- | - | ----- | ----- |  | - | ------ | -
|Fiscal Year                                   |  | Term LoansandLine of Credit |        |   | Capital Leases |   |       | Total | 
|2008                                          |  | $                           | 2,222  |   |                | $ | 1,058 |       |  | $ | 3,280  |  
|2009                                          |  |                             | 361    |   |                |   | 777   |       |  |   | 1,138  |  
|2010                                          |  |                             | 111    |   |                |   |      |       |  |   | 111    |  
|                                              |  |                             |        |   |                |   |       |       |  |   |        |  
|Total minimum payments                        |  |                             | 2,694  |   |                |   | 1,835 |       |  |   | 4,529  |  
|Less amounts representing interest            |  |                             |       |   |                |   | (129  | )     |  |   | (129   | )
|                                              |  |                             |        |   |                |   |       |       |  |   |        |  
|Present value of minimum payments             |  |                             | 2,694  |   |                |   | 1,706 |       |  |   | 4,400  |  
|Less current portion of long-term obligations |  |                             | (2,222 | ) |                |   | (957  | )     |  |   | (3,179 | )
|                                              |  |                             |        |   |                |   |       |       |  |   |        |  
|Non-current portion of long-term obligations  |  | $                           | 472    |   |                | $ | 749   |       |  | $ | 1,221  |  
|                                              |  |                             |        |   |                |   |       |       |  |   |        |  

8. Commitments and Contingencies

Operating Leases

We lease
office, distribution center, and call center facilities under non-cancelable operating leases, which include fixed rental payments ending between 2008 and 2013. We have the option to extend some of these leases for one or more additional terms of
five years. In addition, we lease various office and IT equipment under operating leases. Total rent expense under operating leases was $3.4 million in 2007, $3.0 million for 2006, and $3.1 million for 2005.

In June 2007, we entered into an operating lease for an inventory storage facility for approximately 85,000 square feet through February 2011.

In August 2004, we entered into an operating lease for approximately 53,000 square feet for our corporate headquarters. The lease expires
on July 31, 2013, with two separate five-year renewal options that, if exercised,



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would extend the lease expiration to July 2023. In connection with the lease, we received landlord-provided incentives of approximately $2.3 million in the
form of tenant improvements, which have been recorded as additions to fixed assets and other current and long-term liabilities and are being amortized over the term of the lease. As of December 30, 2007 and December 31, 2006, our long-term
deferred rent liability totaled $1.3 million and $1.6 million, respectively, and our current deferred rent liability totaled $0.3 million.

In connection with the lease arrangements for our corporate headquarters, we are required to provide a standby letter of credit as a security deposit, which will be renewed annually until the end of the lease term. The standby letter of
credit is funded under our revolving line of credit and is not required to be secured with cash.

Future minimum commitments at
December 30, 2007 are as follows:



|                       |  |                  |       
|---------------------- |  | ---------------- | ------
|Fiscal Year            |  | Operating Leases
|2008                   |  | $                | 2,992 
|2009                   |  |                  | 2,945 
|2010                   |  |                  | 3,041 
|2011                   |  |                  | 1,570 
|2012                   |  |                  | 1,487 
|Thereafter             |  |                  | 876   
|                       |  |                  |       
|Total minimum payments |  | $                | 12,911
|                       |  |                  |       

Legal Proceedings

1-800 Contacts Litigation. On February 26, 2008, 1-800 Contacts, Inc. (1-800 Contacts) filed an action in the
U.S. District Court for the District of Utah, Central Division against us and our subsidiary Vision Direct, Inc. for alleged direct and contributory trademark infringement and dilution under federal and Utah state law, unfair competition,
intentional interference with economic relations, and unjust enrichment. One day later, on February 27, 2008, 1-800 Contacts filed a separate action in the U.S. District Court for the Southern District of New York against Vision Direct for an
alleged breach of a 2004 settlement agreement between Vision Direct and 1-800 Contacts. 1-800 Contacts is seeking monetary damages as well as injunctive relief in both actions. We will vigorously contest and defend against the allegations in both
actions.

Due to the inherent uncertainties of litigation, we cannot accurately predict the ultimate outcome of this
matter. We are unable to estimate the potential damages that might be awarded if we were found liable. Because our liability, if any, cannot be reasonably estimated, no amounts have been accrued for this matter. An adverse outcome in
this matter could have a material adverse effect on our financial position and results of operations.

Fair Credit Reporting Act Class
Action Litigation. On February 26, 2008, Aaron Burgess and John James Garland filed a class action lawsuit against us in the U.S. District Court for the Western District of Washington at Seattle alleging breach of a provision of the
Fair Credit Reporting Act related to the printing of credit card receipts. The lawsuit seeks statutory and punitive damages. We will vigorously contest and defend against the allegations in this action.

Due to the inherent uncertainties of litigation, we cannot accurately predict the ultimate outcome of this matter. We are unable to estimate the
potential damages that might be awarded if we were found liable. Because our liability, if any, cannot be reasonably estimated, no amounts have been accrued for this matter. An adverse outcome in this matter could have a material adverse
effect on our financial position and results of operations.



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State Sales Tax Claims. We have not believed that it is required to collect sales taxes
on sales made to customers in New Jersey based on applicable law and, accordingly, has not done so. Nevertheless, in early 2002, we received an arbitrary assessment notice from the state of New Jersey for past sales tax due on such sales from fiscal
years 2000 and 2001, based on its best estimate of sales revenue numbers during those periods. In December 2002, we received a revised assessment for 2000 and 2001 in the amount of $221,626 in tax, plus penalties in the amount of $11,081 and
interest that continues to accrue. In March 2003, we filed an appeal of the revised assessment with the Tax Court of New Jersey, as the state of New Jersey is pursuing its claim specifically against one of our consolidated subsidiaries that is
not a retailing entity in that state. A trial on that appeal was held in late 2006. On February 19, 2008, we were informed of the decision by the Tax Court against us in the case of drugstore.com, inc. vs. Director, Division of
Taxation. In its decision, the Tax Court ruled that we should have collected New Jersey sales tax on all sales to New Jersey customers. We plan to appeal the Tax Courts decision. In the meantime, we intend to begin collecting and
remitting sales tax on taxable New Jersey sales. Given the decision, we believe that it is probable that we have incurred a liability and have recorded an expense of $2.5 million for the estimated taxes and interest in general and administrative
expenses in the consolidated statement of operations for the year ended December 30, 2007. The charge is an estimate of the New Jersey tax liability for the 2000 and 2001 assessment, as well as for all subsequent years through 2007, including
interest.

Class Action Laddering Litigation. On and after July 6, 2001, eight stockholder class action lawsuits were
filed in the United States District Court for the Southern District of New York (the Court) naming drugstore.com as a defendant, along with the underwriters and certain of our present and former officers and directors (the
Individual Defendants), in connection with our July 27, 1999 initial public offering and March 15, 2000 secondary offering (together, the Offerings). A Consolidated Amended Complaint, which is now the operative
complaint, was filed on April 19, 2002. The suit purports to be a class action filed on behalf of purchasers of our common stock during the period July 28, 1999 to December 6, 2000.

In general, the complaint alleges that the prospectuses through which we conducted the Offerings were materially false and misleading because they failed
to disclose, among other things, that (i) the underwriters of the Offerings allegedly had solicited and received excessive and undisclosed commissions from certain investors in exchange for which the underwriters allocated to those investors
material portions of the restricted number of shares issued in connection with the Offerings and (ii) the underwriters allegedly entered into agreements with customers whereby the underwriters agreed to allocate drugstore.com shares to
customers in the Offerings in exchange for which customers agreed to purchase additional drugstore.com shares in the after-market at predetermined prices. The complaint asserts violations of various sections of the Securities Act of 1933, as
amended, and the Securities Exchange Act of 1934, as amended. The action seeks damages in an unspecified amount and other relief. The action is being coordinated with approximately 300 other nearly identical actions filed against other
companies or their former officers and directors.

On October 9, 2002, the Court dismissed the Individual Defendants from the case
without prejudice. On February 19, 2003, the Court denied our motion to dismiss the complaint. On December 5, 2006, the Second Circuit vacated a decision by the district court granting class certification in six of the
coordinated cases, which are intended to serve as test, or focus, cases. The plaintiffs selected these six cases, which do not include us. On April 6, 2007, the Second Circuit denied a petition for rehearing filed by
plaintiffs, but noted that plaintiffs could ask the district court to certify more narrow classes than those that were rejected.

Prior to
the Second Circuits December 5, 2006 ruling, drugstore.com, the plaintiff class, and the vast majority of the other issuer defendants, or, in the case of bankrupt issuers, their directors and officers, submitted a settlement
agreement to the Court for approval. In light of the Second Circuit opinion, the parties agreed that the settlement could no longer be approved. On June 25, 2007, the district court approved a



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stipulation filed by the plaintiffs and the issuers which terminated the proposed settlement. On August 14, 2007, the plaintiffs filed amended
complaints in the six focus cases. The amended complaints include a number of changes, such as changes to the definition of the purported class of investors, and the elimination of the individual defendants as defendants. The six focus case issuers
and the underwriters named as defendants in the focus cases filed motions to dismiss the amended complaints against them on November 14, 2007. On September 27, 2007, the plaintiffs filed a motion for class certification in the six focus
cases. On December 21, 2007, the issuers and the underwriters filed papers opposing plaintiffs class certification motion, and plaintiffs filed an opposition to defendants motions to dismiss. On January 28, 2008, the issuers
and the underwriters filed reply briefs in further support of their motions to dismiss the amended complaints.

Due to the inherent
uncertainties of litigation, we cannot accurately predict the ultimate outcome of this matter. We cannot predict whether we will be able to renegotiate a settlement that complies with the Second Circuits mandate, nor can we predict the
amount of any such settlement and whether that amount would be greater than our insurance coverage. We are unable to estimate the potential damages that might be awarded if we were found liable, there arose a material limitation with respect to
our insurance coverage, or the amount awarded were to exceed our insurance coverage. Because our liability, if any, cannot be reasonably estimated, no amounts have been accrued for this matter. An adverse outcome in this matter could have
a material adverse effect on our financial position and results of operations.

Other.From time to time, we are subject to
other legal proceedings and claims in the ordinary course of business. We are not currently aware of any such legal proceedings or claims that we believe will have, individually or in the aggregate, a material adverse effect on our business
prospects, financial condition, or operating results.

9. Income Taxes

No tax benefit or expense was recorded in 2007, 2006, or 2005 due to our ongoing operating losses. Our deferred tax asset consists primarily of net operating loss carry-forwards and amortization and impairment of
intangible assets. We have provided a valuation allowance for our deferred tax asset to an amount expected to be realized. The increase in the valuation allowance on the deferred tax asset was $12.6 million in 2007 and $2.7 million in 2006.

At December 30, 2007 and December 31, 2006, we had approximately$555.9 million and$538.6 million, respectively, of net
operating loss carry-forwards that will expire beginning in 2019. Internal Revenue Code Section 382 imposes limitations on our ability to utilize net operating losses if we experience an ownership change. An ownership change may result from
transactions increasing the ownership of certain stockholders in the stock of a corporation by more than 50 percentage points over a three-year period. The value of the stock at the time of an ownership change is multiplied by the applicable
long-term tax exempt interest rate to calculate the annual limitation. Any unused annual limitation may be carried over to later years. As of December 30, 2007, there were no significant limitations on the use of our existing net operating loss
under Internal Revenue Code Section 382.

Approximately $8.6 million of our net operating loss carry-forwards are acquired operating loss
carry-forwards. To the extent that we realize these acquired operating loss carry-forwards, the resulting tax benefits would reduce any remaining goodwill related to the acquisition. Approximately $9.7 million of our net loss carry-forwards are
related to tax-deductible stock-based compensation in excess of amounts recognized for financial reporting purposes. To the extent that net operating loss carry-forwards, if realized, relate to stock-based compensation, the resulting tax benefits
will be recorded to stockholders equity, rather than to results of operations.



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Deferred income tax balances reflect the effects of temporary differences between the carrying
amount of assets and liabilities and their tax bases and are stated at the enacted tax rates expected to be in effect when taxes are actually paid or recovered. Significant components of our deferred tax assets and liabilities are as follows:



|                                                               |  |                  |          |   |                  |   |          |  
|-------------------------------------------------------------- |  | ---------------- | -------- | - | ---------------- | - | -------- | -
|                                                               |  | December 30,2007 |          |   | December 31,2006 |  
|                                                               |  | (in thousands)   |         
|                                                               |  |                 
|Deferred tax assets:                                           |  |                  |          |   |                  |   |          |  
|Net operating loss carry-forward (federal)                     |  | $                | 194,559  |   |                  | $ | 182,811  |  
|Net operating loss carry-forward (state)                       |  |                  | 9,479    |   |                  |   | 5,502    |  
|Depreciation, amortization and impairment of intangible assets |  |                  | 37,438   |   |                  |   | 42,951   |  
|Tax credit carry-forwards                                      |  |                  | 1,344    |   |                  |   | 1,239    |  
|Stock compensation                                             |  |                  | 6,204    |   |                  |   | 3,538    |  
|Other temporary differences                                    |  |                  | 1,357    |   |                  |   | 1,704    |  
|                                                               |  |                  |          |   |                  |   |          |  
|Total gross deferred tax assets                                |  |                  | 250,381  |   |                  |   | 237,745  |  
|Less valuation allowance                                       |  |                  | (250,381 | ) |                  |   | (237,745 | )
|                                                               |  |                  |          |   |                  |   |          |  
|Net deferred tax assets, net of valuation allowance            |  |                  |         |   |                  |   |         |  
|Deferred tax liabilities:                                      |  |                  |          |   |                  |   |          |  
|Indefinite-lived intangible asset                              |  |                  | (947     | ) |                  |   | (945     | )
|                                                               |  |                  |          |   |                  |   |          |  
|Net deferred tax liability                                     |  | $                | (947     | ) |                  | $ | (945     | )
|                                                               |  |                  |          |   |                  |   |          |  

A reconciliation of income taxes computed at the statutory rate to the income tax amount recorded
is as follows:



|                                     |  |                  |         |   |                  |   |        |                |  |   |        |  
|------------------------------------ |  | ---------------- | ------- | - | ---------------- | - | ------ | -------------- |  | - | ------ | -
|                                     |  | December 30,2007 |         |   | December 31,2006 |   |        | January 1,2006 | 
|                                     |  | (in thousands)   |        
|Income tax benefit at statutory rate |  | $                | 4,028   |   |                  | $ | 4,428  |                |  | $ | 7,106  |  
|State taxes, net of federal impact   |  |                  | 1,427   |   |                  |   | 214    |                |  |   | 309    |  
|Tax credits                          |  |                  | 123     |   |                  |   | 1,118  |                |  |   |       |  
|Other permanent differences          |  |                  | (67     | ) |                  |   | (476   | )              |  |   | (112   | )
|Impact of rate changeState          |  |                  | 4,756   |   |                  |   |       |                |  |   |       |  
|Impact of rate changeFederal        |  |                  | 2,369   |   |                  |   | (2,614 | )              |  |   |       |  
|Increase in valuation allowance      |  |                  | (12,636 | ) |                  |   | (2,670 | )              |  |   | (7,303 | )
|                                     |  |                  |         |   |                  |   |        |                |  |   |        |  
|Total income tax benefit             |  | $                |        |   |                  | $ |       |                |  | $ |       |  
|                                     |  |                  |         |   |                  |   |        |                |  |   |        |  

10. Stockholders Equity

Outstanding Warrants

In June 2000, in connection with a five-year strategic agreement with
CIGNA HealthCare Companies (CIGNA), we issued Tel-Drug, Inc., a subsidiary of CIGNA, a warrant to purchase 500,000 shares of our common stock at $7.76 per share. In December 2003, Tel-Drug transferred ownership of this warrant, which expires in
December 2008, to Highbridge International LLC.

On February 14, 2005, in connection with the performance of executive recruiting
services, we issued to Heidrick & Struggles, Inc. a warrant to purchase 115,000 shares of our common stock at $2.36 per share, with an



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expiration date in February 2008. The fair value of the warrant totaled $159,000 and is included in the statement of operations in 2005. In November 2006,
Heidrick & Struggles transferred ownership of this warrant to Lehman Brothers, Inc. In February 2008, the warrant was exercised and 115,000 shares of our common stock were issued in exchange for $271,400.

In June 2007, we issued to certain of our financial advisors a fully vested warrant to purchase 200,000 shares of our common stock at $2.50 per share,
which expires in June 2017. The fair value of the warrant, determined using the Black-Scholes option pricing model, totaled $408,000 and is included in general and administrative expenses. In July 2007, we issued a fully vested warrant to purchase
50,000 shares of our common stock at $2.53 per share, expiring in July 2017, in conjunction with a consulting agreement. The fair value of the warrant, determined using the Black-Scholes option pricing model, totaled $121,000 and is included in
general and administrative expenses.

In March 2008, we issued fully vested warrants to purchase an aggregate of 100,000 shares of our
common stock at $2.53 per share, expiring in March 2018, in conjunction with a consulting agreement. The fair value of the warrant, determined using the Black-Scholes option pricing model, totaled $163,000.

Common Stock

In March 2005,
we issued 10.0 million shares of our common stock to Ziff Asset Management, L.P. (Ziff) in a private placement, for cash consideration of $26.0 million. On December 2, 2005, pursuant to the terms of the stock purchase agreement, we filed a
registration statement with the SEC to register the resale of all the common shares. Proceeds received, net of issuance costs of $48,000, were used for general corporate purposes, including, but not limited to, investments in marketing initiatives
and technology infrastructure enhancements.

In October 2005, in connection with a license agreement, we issued 10,000 shares of our common
stock having an aggregate fair value of $34,000.

Common Stock Reserved for Future Issuance

The following table represents the number of shares of common stock reserved for future issuance as of December 30, 2007:



|                                     |  |           
|------------------------------------ |  | ----------
|Stock option plan                    |  | 26,166,329
|Employee stock purchase plan         |  | 2,201,199 
|Warrants to purchase common stock(1) |  | 865,000   
|                                     |  |           
|                                     |  | 29,232,528
|                                     |  |           



|(1) | In February 2008, a warrant was exercised to purchase 115,000
shares of our common stock in exchange for $271,400 and in March 2008, we issued warrants to purchase 100,000 shares of our common stock in conjunction with a consulting agreement.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

11. Employee Benefit Plans

Defined
Contribution Plan

We have adopted a defined contribution retirement plan under Section 401(k) of the Internal Revenue Code,
which covers substantially all of our employees (401(k) Plan). Eligible employees may contribute amounts to the



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401(k) Plan, via payroll withholding, subject to certain limitations. Under the 401(k) Plan, employees may elect to reduce their current compensation by up
to the statutorily prescribed annual limit and to have the amount of such reduction contributed to the 401(k) Plan. The 401(k) Plan permits, but does not require, additional matching contributions to the 401(k) Plan by us on behalf of all
participants in the 401(k) Plan. To date, we have not made any matching contributions to the 401(k) Plan.

1998 Stock Plan

Under the terms of our 1998 Stock Plan, as amended (1998 Stock Plan), our board of directors may grant incentive and nonqualified stock
options to employees, officers, directors, agents, consultants, and independent contractors of drugstore.com. Under the 1998 Stock Plan, an aggregate of 38,618,770 shares of common stock have been reserved for future issuance. Shares for future
issuances are determined by means of an automatic annual increase equal to (i) the lesser of (a) 5% of the outstanding shares of common stock as of the end of the immediately preceding fiscal year or (b) 6,000,000 shares or
(ii) a lesser amount determined by the plan administrator; provided that any shares from any such increase in previous years that are not actually issued will be added to the aggregate number of shares available for issuance under the 1998
Stock Plan. Pursuant to this provision, 4,700,000 were reserved for future issuance on January 1, 2007 (first day of fiscal 2007) and no additional shares were reserved for future issuance on December 31, 2007 (first day of fiscal year
2008). Options granted under this plan generally vest as follows: 20% of the shares vest during the first six months and the remaining 80% vest quarterly over the subsequent 42 months. Our board of directors has delegated to the stock option
subcommittee of the compensation committee of the board the authority to grant options within board-approved guidelines to certain recipients. In addition, our board of directors has authorized our chief executive officer to grant certain options in
connection with offers of employment or consulting engagements, which are subject to the boards subsequent ratification. Option grants generally have exercise prices equal to the fair market value of the common stock on the date of grant and
expire 10 years from the date of grant.

Determining Fair Value

We calculate the fair value of our stock options granted to employees using the Black-Scholes option pricing model using the single option award approach. This fair value is then amortized on a straight-line basis
over the requisite service periods of the awards, which is generally the vesting period. The following weighted-average assumptions were used in arriving at the fair value of each option grant:



|                            |  |                            |      |   |                            |   |      |                          |  |   |      |  
|--------------------------- |  | -------------------------- | ---- | - | -------------------------- | - | ---- | ------------------------ |  | - | ---- | -
|                            |  | Employee Stock Options     |     
|                            |  | Year endedDecember 30,2007 |      |   | Year endedDecember 31,2006 |   |      | Year endedJanuary 1,2006 | 
|Expected volatility         |  |                            | 74   | % |                            |   | 77   | %                        |  |   | 83   | %
|Expected term (in years)    |  |                            | 5.8  |   |                            |   | 6.0  |                          |  |   | 3.2  |  
|Risk-free interest rate     |  |                            | 4.4  | % |                            |   | 4.5  | %                        |  |   | 3.9  | %
|Expected dividend           |  |                            | 0    | % |                            |   | 0    | %                        |  |   | 0    | %
|Weighted-average fair value |  | $                          | 1.89 |   |                            | $ | 2.31 |                          |  | $ | 1.68 |  

Volatility

Our computation of expected volatility is based on our historical volatility, adjusted for changes in capital structure and corporate changes, information available that may indicate future volatility, and observable
mean reversion tendencies of historical volatility. Prior to 2006, our computation of expected volatility was based solely on our historical volatility.



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Expected Term

Our expected term in 2006 and during the first nine months of 2007 was calculated using the simplified method outlined by SEC Staff Accounting Bulletin No. 107, Share-Based Payment (SAB 107). Under this
method, our expected term was equal to the sum of the weighted average vesting term plus the original contractual term divided by two, which resulted in a six-year expected term. Prior to 2006, our computation of expected life was based on vesting
schedules and historical experience of options exercised. In the fourth quarter of 2007, we developed reasonable and supportable expected term estimates utilizing a comprehensive weighted average life (WAL) analysis. The WAL analysis provides a
historical based platform for use in developing expected term estimates for the future based on the historically observed time periods from grant date through post-vesting activities, such as exercise and cancellation. The historical grant data was
segregated into pre-vesting forfeitures, post-vesting forfeitures, outstanding and unvested grants, and outstanding and vested grants and then data was included or excluded in the WAL depending on the applicable contractual or vesting provisions,
differences in other option terms and insufficient elapsed time from grant date or from vesting dates. To develop the expected term, we analyzed by homogenous group, which includes employees, executives, our chief executive officer, board members,
and other non-employees, the weighted average time from grant date to post-vesting activity. For those grants still outstanding, we developed a reasonable assumption regarding the expected time of settlement. This analysis resulted in an expected
term of 4.2 years for board members, 5.5 years for our chief executive officer, 4.2 years for our executives, and 4.4 years for employees.

Risk-Free Interest Rate and Dividend Yield

We base the risk-free interest rate on the implied yield currently available on
U.S. Treasury zero-coupon issues with an equivalent remaining term. Where the expected term of our stock-based awards do not correspond with the terms for which interest rates are quoted, we average the periods to determine the rate from the
available term maturities. A dividend yield of 0% was considered appropriate as we have not issued and do not anticipate issuing any dividends in the near future.

Forfeitures

When estimating forfeitures, we considered historical voluntary termination behavior, in
addition to analyzing actual option forfeitures. In conjunction with this analysis, we identified distinct subgroups: employees, executives, our chief executive officer, board members, and other non-employees. Through the third quarter of 2006, an
estimated forfeiture rate of approximately 30% was applied to employees and executive subgroups based on the weighted average termination behavior of those subgroups. In the fourth quarter of 2006, we reviewed our forfeiture rate analysis, which
resulted in an increase in our forfeiture rate to 35%. We recorded the revised forfeiture rate as a change in estimate, resulting in a reduction of stock-based compensation in 2006 totaling approximately $185,000. In 2007, we determined that our
forfeiture rate of 35% was still applicable. A forfeiture rate of 0% is applied to our chief executive officer, board members, and non-employees. Prior to the adoption of FAS 123(R), we recognized the impact of forfeitures when they occurred.



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Stock Compensation Expense

The following table summarizes stock-based compensation by operating function recorded in the Statement of Operations:



|                                 |  |                            |       |                            |   |                          |  |   |      
|-------------------------------- |  | -------------------------- | ----- | -------------------------- | - | ------------------------ |  | - | -----
|                                 |  | Year endedDecember 30,2007 |       | Year endedDecember 31,2006 |   | Year endedJanuary 1,2006
|                                 |  | (in thousands)            
|Fulfillment and order processing |  | $                          | 784   |                            | $ | 835                      |  | $ | 2    
|Marketing and sales              |  |                            | 1,381 |                            |   | 1,058                    |  |   | 218  
|Technology and content           |  |                            | 1,224 |                            |   | 1,071                    |  |   | 5    
|General and administrative       |  |                            | 5,412 |                            |   | 3,757                    |  |   | 1,743
|                                 |  |                            |       |                            |   |                          |  |   |      
|Total                            |  | $                          | 8,801 |                            | $ | 6,721                    |  | $ | 1,968
|                                 |  |                            |       |                            |   |                          |  |   |      

We recorded stock compensation expense totaling $6,000 in 2007, $30,000 in 2006, and $169,000 in
2005 for the fair value of options granted to non-employees for services.

Certain stock options were modified for terminated employees,
which resulted in a stock compensation charge of $117,000 in 2007, $329,000 in 2006, and $175,000 in 2005.

As of December 30, 2007,
the total compensation cost related to unvested options granted to employees under our 1998 Stock Plan totaled $8.3 million, net of estimated forfeitures of approximately $6.8 million. This cost will be amortized on a straight-line basis over a
weighted-average period of 2.2 years and will be adjusted for subsequent changes in estimated forfeitures.

Stock Option Activity

The following table summarizes activity under our 1998 Stock Plan:



|                                                 |  |                             |   |  |                     |   |  |                                        |      |                                          |      |                                       |   |      
|------------------------------------------------ |  | --------------------------- | - |  | ------------------- | - |  | -------------------------------------- | ---- | ---------------------------------------- | ---- | ------------------------------------- | - | -----
|                                                 |  |                             |   |  | Outstanding Options |   |  |                                        |     
|                                                 |  | SharesAvailablefor Grant(1) |   |  | Number ofShares(1)  |   |  | Weighted-AverageExercisePrice perShare |      | Weighted-AverageRemainingContractualTerm |      | AggregateIntrinsicValue(in thousands)
|Outstanding at December 31, 2006                 |  | 4,493,562                   |   |  | 18,841,842          |   |  | $                                      | 3.49 |                                          |      |                                       |   |      
|                                                 |  |                             |   |  |                     |   |  |                                        |      |                                          |      |                                       |   |      
|Additional shares authorized                     |  | 4,700,000                   |   |  |                    |   |  |                                        |      |                                          |      |                                       |   |      
|Options granted                                  |  | (3,158,775                  | ) |  | 3,158,775           |   |  | $                                      | 2.82 |                                          |      |                                       |   |      
|Options exercised                                |  |                            |   |  | (1,869,075          | ) |  | $                                      | 2.22 |                                          |      |                                       |   |      
|Options forfeited                                |  | 3,389,084                   |   |  | (3,389,084          | ) |  | $                                      | 3.64 |                                          |      |                                       |   |      
|                                                 |  |                             |   |  |                     |   |  |                                        |      |                                          |      |                                       |   |      
|Outstanding at December 30, 2007                 |  | 9,423,871                   |   |  | 16,742,458          |   |  | $                                      | 3.48 |                                          |      |                                       |   |      
|                                                 |  |                             |   |  |                     |   |  |                                        |      |                                          |      |                                       |   |      
|Vested and expected to vest at December 30, 2007 |  |                             |   |  | 13,431,920          |   |  | $                                      | 3.57 |                                          | 7.31 |                                       | $ | 4,342
|                                                 |  |                             |   |  |                     |   |  |                                        |      |                                          |      |                                       |   |      
|Exercisable at December 30, 2007                 |  |                             |   |  | 7,858,914           |   |  | $                                      | 3.91 |                                          | 6.75 |                                       | $ | 2,734
|                                                 |  |                             |   |  |                     |   |  |                                        |      |                                          |      |                                       |   |      



|(1) | The balance as of December 31, 2006 has been adjusted for
153,982 shares forfeited during 2006 not reported in our annual report on 10-K for the year ended December 31, 2006.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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DRUGSTORE.COM, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



The aggregate intrinsic value is calculated as the difference between the exercise price of the
underlying awards and the market price of our common stock for the 11.1 million shares subject to options that were in-the-money at December 30, 2007 (i.e., with an exercise price of $3.28 or less). The aggregate intrinsic value of options
exercised was $1.4 million, $2.0 million and $2.8 million during the years ended December 30, 2007, December 31, 2006, and January 1, 2006.

1999 Employee Stock Purchase Plan

Under the terms of our 1999 Employee Stock Purchase Plan,
as amended (1999 Employee Stock Purchase Plan), a total of 500,000 shares of common stock were initially reserved for issuance, and there is an annual increase on the first day of each fiscal year equal to the lesser of (1) 500,000 shares,
(2) three percent (3%) of our shares outstanding on the last day of the immediately preceding fiscal year, or (3) such lesser number of shares as may be determined by the board of directors. Eligible employees may purchase common
stock under the 1999 Employee Stock Purchase Plan for a purchase price equal to 85% of the fair market value of our common stock on the first or last day, whichever is less, of the applicable six-month purchase period. For the years ended
December 30, 2007, December 31, 2006, and January 1, 2006 employees purchased 92,585, 102,283, and 127,952 shares, respectively, of our common stock under the 1999 Employee Stock Purchase Plan in exchange for $224,000, $266,000,
and $294,000, respectively. As of December 30, 2007, there were 2,201,199 shares reserved for future issuance under the 1999 Employee Stock Purchase Plan.

12. Related Parties

For the year ended January 1, 2006, we recorded revenues of $6.3 million by acting as a
nonexclusive wholesaler and fulfillment provider for certain OTC products sold through the Health & Personal Care store on the Amazon.com website. Effective November 9, 2005, we terminated this agreement with Amazon.com. No amounts
were due as of December 31, 2006 and no revenue was generated for the year ended December 31, 2006. For the year ended December 30, 2007, we recorded revenue of $124,000 and referral fees of $20,000, under our new merchant agreement
with Amazon.com entered into in September 2007, to sell prestige beauty products on their website. Amounts due from Amazon.com totaled $21,000 as of December 30, 2007.

13. Segment Information

We have four reporting segments: OTC, vision, mail-order pharmacy, and local
pick-up pharmacy. The OTC segment is comprised of the sales and related costs of selling all non-prescription products through our websites, including drop-ship arrangements with our vendors, customized nutritional supplement programs through CNS,
and net sales of consignment products. Our vision segment is comprised of sales and the related costs of selling contact lenses through Vision Direct. The mail-order pharmacy segment is comprised of sales and the related costs of selling
pharmaceuticals through the drugstore.com website for mail-order delivery. The local pick-up pharmacy segment is comprised of sales and the related costs of selling pharmaceuticals through the drugstore.com website and the RiteAid.com website for
pick-up at a local Rite Aid store. We operate and evaluate our business segments based on contribution margin results. We define contribution margin as net sales attributable to a segment, less the direct cost of these sales and the incremental
(variable) costs of fulfilling, processing, and delivering the order (labor, packaging supplies, credit card fees, and royalty costs that are variable based on sales volume).



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DRUGSTORE.COM, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



The information presented below for these segments is information used by our chief operating
decision maker in evaluating operating performance.



|                         |  |                 |         |                 |   |                 |  |   |        
|------------------------ |  | --------------- | ------- | --------------- | - | --------------- |  | - | -------
|                         |  | FiscalYear 2007 |         | FiscalYear 2006 |   | FiscalYear 2005
|                         |  | (in thousands) 
|Over- the-Counter (OTC): |  |                 |         |                 |   |                 |  |   |        
|Net sales                |  | $               | 234,282 |                 | $ | 197,964         |  | $ | 180,566
|Cost of sales            |  |                 | 164,469 |                 |   | 139,674         |  |   | 130,346
|Variable order costs(a)  |  |                 | 22,259  |                 |   | 18,650          |  |   | 19,069 
|                         |  |                 |         |                 |   |                 |  |   |        
|Contribution margin(b)   |  | $               | 47,554  |                 | $ | 39,640          |  | $ | 31,151 
|                         |  |                 |         |                 |   |                 |  |   |        
|Vision:                  |  |                 |         |                 |   |                 |  |   |        
|Net sales                |  | $               | 54,906  |                 | $ | 49,780          |  | $ | 47,126 
|Cost of sales            |  |                 | 41,904  |                 |   | 38,682          |  |   | 37,008 
|Variable order costs(a)  |  |                 | 2,708   |                 |   | 2,478           |  |   | 2,858  
|                         |  |                 |         |                 |   |                 |  |   |        
|Contribution margin(b)   |  | $               | 10,294  |                 | $ | 8,620           |  | $ | 7,260  
|                         |  |                 |         |                 |   |                 |  |   |        
|Local Pick-Up Pharmacy:  |  |                 |         |                 |   |                 |  |   |        
|Net sales(c)             |  | $               | 106,392 |                 | $ | 100,654         |  | $ | 96,126 
|Cost of sales            |  |                 | 93,611  |                 |   | 89,654          |  |   | 84,660 
|Variable order costs(a)  |  |                 | 4,383   |                 |   | 4,128           |  |   | 4,030  
|                         |  |                 |         |                 |   |                 |  |   |        
|Contribution margin(b)   |  | $               | 8,398   |                 | $ | 6,872           |  | $ | 7,436  
|                         |  |                 |         |                 |   |                 |  |   |        
|Mail-Order Pharmacy:     |  |                 |         |                 |   |                 |  |   |        
|Net sales                |  | $               | 50,143  |                 | $ | 67,379          |  | $ | 75,612 
|Cost of sales            |  |                 | 41,935  |                 |   | 58,026          |  |   | 65,352 
|Variable order costs(a)  |  |                 | 3,967   |                 |   | 5,501           |  |   | 6,959  
|                         |  |                 |         |                 |   |                 |  |   |        
|Contribution margin(b)   |  | $               | 4,241   |                 | $ | 3,852           |  | $ | 3,301  
|                         |  |                 |         |                 |   |                 |  |   |        
|Consolidated:            |  |                 |         |                 |   |                 |  |   |        
|Net sales(d)             |  | $               | 445,723 |                 | $ | 415,777         |  | $ | 399,430
|Cost of sales            |  |                 | 341,919 |                 |   | 326,036         |  |   | 317,366
|Variable order costs(a)  |  |                 | 33,317  |                 |   | 30,757          |  |   | 32,916 
|                         |  |                 |         |                 |   |                 |  |   |        
|Contribution margin(b)   |  | $               | 70,487  |                 | $ | 58,984          |  | $ | 49,148 
|                         |  |                 |         |                 |   |                 |  |   |        



|(a) | These amounts include all variable costs of fulfillment and
order processing, including labor, packaging supplies, and credit card fees, and royalty costs that are variable based on sales volume. These amounts exclude depreciation, fixed overhead costs, and stock-based compensation.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(b) | Contribution margin represents a measure of how well each segment is contributing to our operating goals. It is
calculated as net sales less the direct cost of these sales and the incremental (variable) fulfillment and order processing costs of delivering orders to our customers and royalty costs.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(c) | Net sales in our local pick-up pharmacy include co-payments totaling $23.1 million for 2007, $22.1 million for 2006, and
$21.1 million for 2005.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------

|(d) | Net sales in 2007, 2006, and 2005 were comprised of 99% of sales in the United States of America and 1% of sales
internationally.
|--- | ---------------------------------------------------------------------------------------------------------------------------------



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DRUGSTORE.COM, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



|                                                         |  |   |         |   |  |   |         |   |  |   |         |  
|-------------------------------------------------------- |  | - | ------- | - |  | - | ------- | - |  | - | ------- | -
|Consolidated contribution margin for reportable segments |  | $ | 70,487  |   |  | $ | 58,984  |   |  | $ | 49,148  |  
|Less:                                                    |  |   |         |   |  |   |         |   |  |   |         |  
|Fixed fulfillment and order processing(e)                |  |   | 10,988  |   |  |   | 10,404  |   |  |   | 9,391   |  
|Marketing and sales(f)                                   |  |   | 32,265  |   |  |   | 29,673  |   |  |   | 30,358  |  
|Technology and content                                   |  |   | 18,258  |   |  |   | 16,190  |   |  |   | 12,773  |  
|General and administrative                               |  |   | 20,928  |   |  |   | 15,413  |   |  |   | 15,791  |  
|Amortization of intangible assets                        |  |   | 1,234   |   |  |   | 2,060   |   |  |   | 3,004   |  
|                                                         |  |   |         |   |  |   |         |   |  |   |         |  
|Operating loss                                           |  | $ | (13,186 | ) |  | $ | (14,756 | ) |  | $ | (22,169 | )
|                                                         |  |   |         |   |  |   |         |   |  |   |         |  



|(e) | These amounts include all fixed costs of fulfillment and order
processing that are not discernable by business segment.
|--- | -----------------------------------------------------------------------------------------------------------------------

|(f) | These amounts exclude CNS and other royalty expenses of $105,000 in 2007, $62,000 in 2006, and $2.5 million in 2005 that
are included in variable costs.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------

The following table presents assets by segment and geographic asset information:



|                             |  |                  |         |                  |   |        
|---------------------------- |  | ---------------- | ------- | ---------------- | - | -------
|                             |  | December 30,2007 |         | December 31,2006
|                             |  | (in thousands)  
|Total Assets:                |  |                  |         |                  |   |        
|Over- the-Counter (OTC)      |  | $                | 40,731  |                  | $ | 39,357 
|Local Pick-Up Pharmacy       |  |                  | 39,963  |                  |   | 32,138 
|Mail-Order Pharmacy          |  |                  | 5,436   |                  |   | 7,970  
|Vision                       |  |                  | 31,949  |                  |   | 31,624 
|Corporate                    |  |                  | 57,329  |                  |   | 57,233 
|                             |  |                  |         |                  |   |        
|Consolidated                 |  | $                | 175,408 |                  | $ | 168,322
|                             |  |                  |         |                  |   |        
|Property and Equipment, Net: |  |                  |         |                  |   |        
|United States of America     |  | $                | 25,417  |                  | $ | 18,183 
|Canada                       |  |                  | 84      |                  |   | 110    
|                             |  |                  |         |                  |   |        
|                             |  | $                | 25,501  |                  | $ | 18,293 
|                             |  |                  |         |                  |   |        



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DRUGSTORE.COM, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



14. Quarterly Results of Operations (unaudited)

The following tables contain selected unaudited consolidated statement of operations information for each quarter of fiscal years 2007 and 2006. We
believe that the following information reflects all normal recurring adjustments necessary for a fair presentation of the information for the periods presented. The operating results for any quarter are not necessarily indicative of results for any
future period.



|                                                                   |  |                                         |            |   |                                     |   |            |               |  |   |              |   |  |               |            |   |              |   |            |               |  |   |              |   |  |   |            |   |  |   |            |  
|------------------------------------------------------------------ |  | --------------------------------------- | ---------- | - | ----------------------------------- | - | ---------- | ------------- |  | - | ------------ | - |  | ------------- | ---------- | - | ------------ | - | ---------- | ------------- |  | - | ------------ | - |  | - | ---------- | - |  | - | ---------- | -
|                                                                   |  | Fiscal Year Ended December 30, 2007     |            |   | Fiscal Year Ended December 31, 2006 |  
|                                                                   |  | FourthQuarter (2)                       |            |   | ThirdQuarter                        |   |            | SecondQuarter |  |   | FirstQuarter |   |  | FourthQuarter |            |   | ThirdQuarter |   |            | SecondQuarter |  |   | FirstQuarter |  
|                                                                   |  | ($ in thousands, except per share data) |           
|Net sales                                                          |  | $                                       | 118,223    |   |                                     | $ | 107,323    |               |  | $ | 110,412      |   |  | $             | 109,765    |   |              | $ | 108,598    |               |  | $ | 100,634      |   |  | $ | 102,436    |   |  | $ | 104,109    |  
|Cost of sales                                                      |  |                                         | 89,109     |   |                                     |   | 82,431     |               |  |   | 85,317       |   |  |               | 85,062     |   |              |   | 85,190     |               |  |   | 79,012       |   |  |   | 79,945     |   |  |   | 81,889     |  
|Net loss                                                           |  |                                         | (2,344     | ) |                                     |   | (2,374     | )             |  |   | (3,015       | ) |  |               | (3,778     | ) |              |   | (2,947     | )             |  |   | (2,593       | ) |  |   | (2,193     | ) |  |   | (5,293     | )
|Basic and diluted net loss per share (1):                          |  | $                                       | (0.02      | ) |                                     | $ | (0.02      | )             |  | $ | (0.03        | ) |  | $             | (0.04      | ) |              | $ | (0.03      | )             |  | $ | (0.03        | ) |  | $ | (0.02      | ) |  | $ | (0.06      | )
|                                                                   |  |                                         |            |   |                                     |   |            |               |  |   |              |   |  |               |            |   |              |   |            |               |  |   |              |   |  |   |            |   |  |   |            |  
|Shares used in computation of basic and diluted net loss per share |  |                                         | 96,229,531 |   |                                     |   | 95,664,011 |               |  |   | 95,006,512   |   |  |               | 94,500,129 |   |              |   | 94,027,508 |               |  |   | 93,488,258   |   |  |   | 93,136,203 |   |  |   | 92,969,650 |  



|(1) | Net loss per share is computed independently for each of the
quarters presented. Therefore, the sum of the quarterly net loss per share may not equal the annual net loss per share.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(2) | Fourth quarter of fiscal 2007 includes a $2.5 million expense for estimated taxes and interest resulting from an
unfavorable ruling on our New Jersey sales tax case. See Note 8.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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DRUGSTORE.COM, INC.

SCHEDULE IIVALUATION AND QUALIFYING ACCOUNTS

(in thousands)



|                                |  |                                     |     |                                      |   |            |  |   |                                |     |  |   |    
|------------------------------- |  | ----------------------------------- | --- | ------------------------------------ | - | ---------- |  | - | ------------------------------ | --- |  | - | ---
|Description                     |  | Balance atbeginning offiscal period |     | Charges torevenue, costsand expenses |   | Deductions |  |   | Balance at endof fiscal period
|Year Ended December 30, 2007    |  |                                     |     |                                      |   |            |  |   |                                |     |  |   |    
|Allowance for doubtful accounts |  | $                                   | 38  |                                      | $ | 85         |  | $ | 82                             | (a) |  | $ | 41 
|Allowance for sales returns     |  |                                     | 339 |                                      |   | 3,491      |  |   | 3,337                          | (b) |  |   | 493
|Reserve for inventory valuation |  |                                     | 509 |                                      |   | 732        |  |   | 829                            | (c) |  |   | 412
|Year Ended December 31, 2006    |  |                                     |     |                                      |   |            |  |   |                                |     |  |   |    
|Allowance for doubtful accounts |  | $                                   | 101 |                                      | $ | 159        |  | $ | 222                            | (a) |  | $ | 38 
|Allowance for sales returns     |  |                                     | 369 |                                      |   | 2,742      |  |   | 2,772                          | (b) |  |   | 339
|Reserve for inventory valuation |  |                                     | 592 |                                      |   | 418        |  |   | 501                            | (c) |  |   | 509
|Year Ended January 1, 2006      |  |                                     |     |                                      |   |            |  |   |                                |     |  |   |    
|Allowance for doubtful accounts |  | $                                   | 98  |                                      | $ | 294        |  | $ | 291                            | (a) |  | $ | 101
|Allowance for sales returns     |  |                                     | 171 |                                      |   | 3,049      |  |   | 2,851                          | (b) |  |   | 369
|Reserve for inventory valuation |  |                                     | 378 |                                      |   | 949        |  |   | 735                            | (c) |  |   | 592



|(a) | Deductions consist of write-offs of uncollectible accounts, net of recoveries.
|--- | ------------------------------------------------------------------------------

|(b) | Deductions consist of sales credits to customers for product returns.
|--- | ---------------------------------------------------------------------

|(c) | Deductions consist of write-off of obsolete inventory and
inventory shrinkage.
|--- | ------------------------------------------------------------------------------



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SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934,
the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized, on March 13, 2008.



DRUGSTORE.COM, INC.By:

/s/    DAWN G. LEPOREDawn G. Lepore President, Chief Executive Officer and Chairman of the Board


POWER OF ATTORNEY

Each person whose individual signature appears below hereby authorizes and appoints Dawn G. Lepore and Thère du Pont, and each of them, with full
power of substitution and resubstitution and full power to act without the other, as his or her true and lawful attorney-in-fact and agent to act in his or her name, place and stead and to execute in the name and on behalf of each person,
individually and in each capacity stated below, and to file, any and all amendments to this report, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting
unto such attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing, ratifying and confirming all that said attorneys-in-fact and agents or any of them or their or his or her substitute
or substitutes may lawfully do or cause to be done by virtue thereof.

Pursuant to the requirements of the Securities Exchange Act of 1934,
this Report has been signed below by the following persons on behalf of the registrant and in the capacities indicated as of March 13, 2008.



|                                                   |  |                                                                                                         
|-------------------------------------------------- |  | --------------------------------------------------------------------------------------------------------
|Signature                                          |  | Title                                                                                                   
|                                                   | 
|/s/    DAWN G.
LEPORE Dawn G. Lepore               |  | President, Chief Executive Officer and Chairman of the Board (Principal Executive Officer)              
|                                                   | 
|/s/    THÈRE DU
PONT Thère du Pont                 |  | Sr. Vice President, Operations, and Chief Financial Officer (Principal Financial and Accounting Officer)
|                                                   | 
|/s/    RICHARD W. BENNET
III Richard W. Bennet III |  | Director                                                                                                
|                                                   | 
|/s/    GEOFFREY R.
ENTRESS Geoffrey R. Entress     |  | Director                                                                                                
|                                                   | 
|/s/    JEFFREY M.
KILLEEN Jeffrey M. Killeen       |  | Director                                                                                                
|                                                   | 
|/s/    WILLIAM D.
SAVOY William D. Savoy           |  | Director                                                                                                
|                                                   | 
|/s/    GREGORY S.
STANGER Gregory S. Stanger       |  | Director                                                                                                



89