# UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF

PREVENTION, PESTICIDES, AND

TOXIC SUBSTANCES



# PC Code: 080818

DP Barcodes: 356960, 356962, 367091, 368703

February 25, 2010

MEMORANDUM

SUBJECT: Indaziflam: Transmittal of Data Evaluation Records for Environmental Fate

Studies.

TO: Erik Kraft, Risk Manager

Registration Division (7509P)

James Tompkins, Product Manager

Registration Division (7509P)

FROM: Reuben Baris, Physical Scientist

Environmental Risk Branch IV

Environmental Fate and Effects Division (7507P )

REVIEWED

BY: Cheryl Sutton, Ph.D., Environmental Scientist

Environmental Risk Branch IV

Environmental Fate and Effects Division (7507P )

APPROVED

BY: Elizabeth Behl, Chief

Environmental Risk Branch IV

Environmental Fate and Effects Division (7507P )

This memo serves to document the Envir onmental Fate and Eff ects Division’s (EFED)

reviews of and conclusions on the acceptability of the submitted indaziflam environmental fate

studies. EFED study classifications are presented in the attached Table

.GuidelineStudy TitleMRIDElectronic FileNameClassificationCommentsAre dataadequatefor RiskAssessment?CurrentAdditionalData Need835.2120Hydrolysis47443207080818 47443207835.2120.docAcceptableNo significant issues affecting the acceptability of the studywere noted.YesNone835.2240Photodegradationin Water47443208080818 47443208835.2240.docSupplementalStudy duration not sufficient. Concentrations of the 2 majortransformation products were still increasing at the studytermination, precluding the determination of the patterns offormation and decline for each.YesNone835.2410Photodegradationon Soil47443209080818 47443209835.2410.docSupplementalStudy duration not sufficient.There was a decline in the dark controls (11%), materialbalances are acceptable. No explainable reason for declinein dark controls (e.g., stable to hydrolysis)YesNone47443210080818 47443210835.4100.docSupplementalApplication rate was 4x themaximum proposed applicationrate to achieve appropriate sensitivity. Kinetics may not beaccurately represented at the higher application mass.Overall recoveries of C14 residues from decreased duringthe study duration.Authors did not demonstrate that volatile trapping methodwas efficient at trapping high concentrations of volatilegases (e.g., CO2)None47443211080818 47443211835.4100.docSupplementalApplication rate was 4x themaximum proposed applicationrate to achieve appropriate sensitivity. Kinetics may not beaccurately represented at the higher application mass.In the California sandy loam, increasing % of AR fordiaminotriazine was observedat the termination of thestudy precluding the determination of the patterns offormation and decline.None.835.4100Aerobic SoilMetabolism47443212080818 47443212835.4100.docSupplementalStudy duration not sufficient. This may not be sufficient toaccurately establish the pattern of decline of the majortransformation products.Replicates were not collected for three of the four soilstested, except for time 0.Moisture content was higher than recommended in studyguidelines (55% of max holding capacity vs 75% of 1/3 barsoil moisture content)YesNoneGuidelineStudy TitleMRIDElectronic FileNameClassificationCommentsAre dataadequatefor RiskAssessment?CurrentAdditionalData Need47443213080818 47443213835.4100.docSupplementalStudy duration not sufficient. This may not be sufficient toaccurately establish the pattern of decline of the majortransformation products.Replicates were not collected for three of the four soilstested, except for time 0.Moisture content was higher than recommended in studyguideline (55% of max holding capacity vs 75% of 1/3 barsoil moisture content)None47443214080818 47443214835.4100.docSupplementalStudy was conducted using diaminotraizine (a degradate)as the starting materialStudy duration not sufficient. This may not be sufficient toaccurately establish the pattern of decline of the majortransformation products.Moisture content was higher than recommended in studyguideline (55% of max holding capacity vs 75% of 1/3 bar)None47443215080818 47443215835.4100.docSupplementalA comparison of the behavior of the two active isomers.Samples were analyzed only for the parent compounds.This study does not provide quantitative data for the riskassessment, it shows the behavior of the two active isomers(diastereomers) of indaziflam (BCS AA10717).Used only forqualitativepurposes.None835.4200Anaerobic SoilMetabolism47443216080818 47443216835.4200.docAcceptableMoisture content during the aerobic phase was higher thanrecommended in study guidelines (55% of max holdingcapacity vs 75% of 1/3 bar)YesNone835.4300Aerobic AquaticMetabolism47443217080818 47443217835.4300.docSupplementalStudy duration not sufficient. Duration not be sufficient toaccurately establish the pattern of decline of the majortransformation products.YesNone47443218080818 47443218835.4400.docAcceptableStudy conducted on Indane labeled compound.YesNone835.4400AnaerobicAquaticMetabolism47443219080818 47443219835.4400.docAcceptableStudy conducted on Triazine labeled compound.YesNone47443203080818 47443203835.1230.docAcceptableNo significant issues affecting the acceptability of the studywere noted.YesNone835.1230Mobility -Adsorption /Desorption47443204080818 47443204835.1230.docSupplementalThe test compound was triazine-indanone a transformationproduct of AE 1170437.YesNoneGuidelineStudy TitleMRIDElectronic FileNameClassificationCommentsAre dataadequatefor RiskAssessment?CurrentAdditionalData Need47443205080818 47443205835.1230.docSupplementalThe test compound was diaminotriazine a transformationproduct of AE 1170437.YesNone47443206080818 47443206835.1230.docSupplementalThe test compound was AE 1170437-carboxylic acid atransformation product of AE 1170437.YesNone47443220080818 47443220835.6100.docSupplementalStudy conducted on CA Porterville sandy loam croppedwith turf.Storage stability study showed slow degradation ofdegradate over the period of frozen storage.None47443221080818 47443221835.6100.docSupplementalStudy conducted on FL Monticello loamy sand croppedwith turf.Storage stability study showed slow degradation ofdegradate over the period of frozen storage.None47443222080818 47443222835.6100.docSupplementalStudy conducted on NC Wayne County loamy sandcropped with turf.Storage stability study showed slow degradation ofdegradate over the period of frozen storage.None47443223080818 47443223835.6100.docSupplementalStudy conducted on CA Porterville sandy loam, bare soil.Storage stability study showed slow degradation ofdegradate over the period of frozen storage.None47443224080818 47443224835.6100.docSupplementalStudy conducted on FL Jefferson County sand/loamy sand,bare soil.Storage stability study showed slow degradation ofdegradate over the period of frozen storage.None47443225080818 47443225835.6100.docSupplementalStudy conducted on NC Wayne County loamy sand, baresoil.Storage stability study showed slow degradation ofdegradate over the period of frozen storage.None835.6100Terrestrial FieldDissipation47743301080818 47743301835.6100.docSupplementalStudy conducted on Quincy loamy sand, bare soil, inEphrata, Washington.Storage stability study showed slow degradation ofdegradate over the period of frozen storage.YesNoneGuidelineStudy TitleMRIDElectronic FileNameClassificationCommentsAre dataadequatefor RiskAssessment?CurrentAdditionalData Need47743302080818 47743302835.6100.docSupplementalStudy was conducted on Oakville loamy sand, bare soil, inNorth Rose, New York.Storage stability study showed slow degradation ofdegradate over the period of frozen storage.None850.1730FishAccumulation47443237680818 47443237850.1730.docAcceptableNo significant issues affecting the acceptability of the studywere noted.YesNoneStorage stability47443279080818 47443279835.6100.docSupplementalSamples fortified with olefin degraded slowly, (correctedmean recoveries 65-88% following 427-433 days).Samples were not stored for a sufficient duration.N/ANone860.1380Storage Stability47743328080818 47743328NG.docSupplementalStudy upgrades MRID 47443279; conducted for sufficientduration. Samples fortified with olefin degraded slowly,mean corrected recoveries ranging from 65 to 88%following 427 to 433 days and from 47 to 67% following732 to 736 days of storageN/ANoneNonguidelineSupplementalInformation onForeign Soils47793401080818 47793401NG.tifSupplementalComparison of foreign (German) soils to location and soiltaxonomy of US soil series.YesNoneNonguidelineECM method &ILV Review474432714744327347443274080818 474432714744327347443274 methodvalidation.pdfAcceptableMethod for the determination of indaziflam and itsdegradates in surface, drinking and ground waters.N/ANoneNonguidelineECM methodReview & ILVreview4744327647443278080818 47443276methodvalidation.pdfAcceptableMethod for the determination of indaziflam and itsdegradates in soil and sediment.Method was determined to be acceptable with minorrevisions.YesNoneNonguidelineECM methodReview47443270N/AExtraneousSubmissionN/AN/ANoneNonguidelineECM methodReview47443275N/AExtraneousSubmissionN/AN/ANoneNonguidelineECM methodReview47443277N/AExtraneousSubmissionN/AN/ANone