Amendment No. 4 to License Agreement



 Exhibit 10.4(E) 

Amendment No. 4 to License Agreement between 
 the Regents of The University of Michigan and 
 OncoMed Pharmaceuticals,
Inc. 
 The License Agreement dated as of January 5, 2001, as heretofore amended (the “License Agreement”),
between the REGENTS OF THE UNIVERSITY OF MICHIGAN, a constitutional corporation of the State of Michigan (“Michigan”) and ONCOMED PHARMACEUTICALS, INC., a Delaware corporation having offices at 265 N. Whisman Road, Mountain
View, CA 94043 (“Licensee”), is hereby amended as follows: 
 1. Without limiting the generality of the definition of
“Licensed Patent(s)” set forth in Section 30.4 of the License Agreement, Licensed Patents comprise the list of patent applications, disclosures and OTT files set forth on Attachment B hereto, and Attachment B referenced in
Section 30.4 of the License Agreement is hereby amended by substituting in full Attachment B hereto. 
 2. Michigan hereby
deems any and all of the support obligations of Licensee of continued research in the laboratories of Dr. Wicha and Dr. Clarke relating to the Licensed Field as described in Section 4.6 of the License fully satisfied, and Michigan
hereby agrees that Licensee is relieved of any and all obligations to provide any payment pursuant to Section 4 of Amendment No. 1 to the License Agreement for the twelve-month period from July 21, 2004 and for any twelve-month period
thereafter. 
 3. The License Agreement, as amended by this Amendment No. 4, shall otherwise remain unaltered and in full
force and effect. 
 4. This Amendment No. 4 may be executed in counterparts, each of which shall be deemed an original,
but both of which together shall constitute one and the same instrument. 
 IN WITNESS WHEREOF, the parties have executed this Amendment
No. 4 by their duly authorized officers or representatives effective as of December 12, 2005. 
  

									
	 ONCOMED PHARMACEUTICALS, INC.
	 		 	THE REGENTS OF THE UNIVERSITY OF MICHIGAN
					
	By	 	/s/ James N. Woody	 		 	By:	 	/s/ Kenneth J. Nisbet
		 	James N. Woody, M.D., Ph.D.	 		 	Name:	 	Kenneth J. Nisbet
		 	Chief Executive Officer	 		 	Title:	 	Executive Director, UM Technology Transfer









																					
	 File #
	 	 Lic Rep
	 	 Title
	 	Name	 	Department	 	Filing Date	 	 	Appl #	 	Country	 	Application Type	 	Patent Status
	 3223
	 	Robin Rasor	 	Methods for Identifying Mouse Breast Cancer Stem Cells	 	Michael F. Clarke	 	Internal Medicine Department	 	 	10/31/2005	  	 	60/731,470	 	US	 	PRV - Provisional	 	Pending
	 3222
	 	Robin Rasor	 	Methods for Treating and Diagnosing Cancer: Array Analysis of Colin and Head and Neck Cancer Stem Cells – This is a Marker	 	Michael F. Clarke	 	Internal Medicine Department	 	 	10/31/2005	  	 	60/731,465	 	US	 	PRV - Provisional	 	Pending
	 3221
	 	Robin Rasor	 	Methods for Treating and Diagnosing Cancer: Array Analysis of Colon and Head and Neck Cancer Stem Cells	 	Michael F. Clarke	 	Internal Medicine Department	 	 	10/31/2005	  	 	60/731,469	 	US	 	PRV - Provisional	 	Pending
	 3211
	 	Robin Rasor	 	Methods for Treating and Diagnosing Head and Neck Cancer	 	Michael F. Clarke	 	Internal Medicine Department	 	 	10/31/2005	  	 	60/731,279	 	US	 	PRV - Provisional	 	Pending
	 3097
	 	Robin Rasor	 	Methods for Treating and Diagnosing Cancer	 	Michael F. Clarke	 	Internal Medicine	 	 
  
	6/13/2005
 6/13/2005
	  
   
	 	60/690,003
 60/690,001
	 	US
 US
	 	PRV - Provisional	 	Pending
 Pending

	 2705
	 	Robin Rasor	 	Cancer Stem Cells and Notch	 	Michael F. Clarke	 	Internal Medicine	 	 
  
  
	02/03/2004
 02/03/2005

02/03/2005
	  
   

  
	 	60/541,527
 11/050,282

PCT/US05/03419
	 	US
 US
 PCT
	 	PRV - Provisional
 ORD - Ordinary

PCT - Patent Cooperation Treaty
	 	Pending
 Pending

Pending

	 2629
	 	Robin Rasor	 	Genes Expressed by Cancer Stem Cells	 	Michael F. Clarke	 	Internal Medicine	 	 
  
  
  
	06/09/2003
 06/09/2003

06/09/2004

06/09/2004
	  
   

  
   
	 	60/477,235
 60/477,228

10/864,207
 PCT/US04/18266
	 	US
 US
 US
 PCT
	 	PRV - Provisional
 PRV - Provisional

ORD - Ordinary

PCT - Patent Cooperation Treaty
	 	Converted
 Converted

Pending
 Pending

	 2237
	 	Robin Rasor	 	Breast Cancer Stem Cells and Notch Signaling	 	Michael F. Clarke	 	Internal Medicine	 	 
  
  
  
  
  
  
	12/07/2001
 12/06/2002

10/29/2004

12/06/2002

12/06/2002

12/06/2002

12/06/2002
	  
   

  
   

  
   

  
	 	60/338,358
 PCT/US02/39191

10/497,791
 2002364537

2469204
 02799914.3

2003-551505
	 	US
 PCT
 US
 AU
 CA
 EP
 JP
	 	PRV - Provisional

PCT - Patent Cooperation Treaty
 371 - US from PCT as Foreign
 PCT - Nat. Stg.

PCT - Nat. Stg.
 PCT - Nat. Stg.

PCT - Nat. Stg.
	 	Converted
 Nationalized

Pending
 Pending

Pending
 Pending

Pending

	 1980
	 	Robin Rasor	 	An Efficient Xenograft Human Epithelial Cancer Model	 	Michael F. Clarke	 	Internal Medicine	 	 
  
  
	10/13/2000
 08/02/2001

08/01/2001
	  
   

  
	 	60/240,317
 PCT/US01/24243

09/920,517
	 	US
 PCT
 US
	 	PRV - Provisional

PCT - Patent Cooperation Treaty
 ORD - Ordinary
	 	Converted
 Nationalized

Allowed

	 1876
	 	Robin Rasor	 	Purification of a Breast Cancer Tumor Initiating (Stem) Cell	 	Michael F. Clarke	 	Internal Medicine	 	 
  
	08/02/2001
 08/01/2001
	  
   
	 	PCT/US01/24243
 09/920,517
	 	PCT
 US
	 	PCT - Patent Cooperation Treaty
 ORD -
Ordinary
	 	Nationalized
 Allowed

	 1819c1
	 	Robin Rasor	 	Isolation and Use of Solid Tumor Stem Cells	 	Michael F. Clarke	 	Internal Medicine	 	 	1/31/2003	  	 	10/343,692	 	US	 	371 - US from PCT as Foreign	 	Pending
	 1819    
	 	Robin Rasor	 	Cancer Stem Cells                         
                                         
  	 	Michael F. Clarke	 	Internal Medicine                    	 	 
  
  
  
  
  
  
  
  
  
  
  
  
	08/03/2000
 10/13/2000

08/02/2001
 08/01/2001

08/02/2001
 08/02/2001

08/02/2001
 08/02/2001

01/31/2003
 06/10/2005

06/10/2005
 00/00/0000

00/00/0000
	  
   

  
   

  
   

  
   

  
   

  
   

  
	 	60/222,794
 60/240,317

PCT/US01/24243
 09/920,517

2001278134
 2417909

01956101.8
 2002-517738

10/343,692
 11/150,073

11/150,524
	 	US
 US
 PCT
 US
 AU
 CA
 EP
 JP
 US
 US
 US
 US
 US
	 	PRV - Provisional

PRV - Provisional

PCT - Patent Cooperation Treaty
 ORD - Ordinary
 PCT - Nat. Stg.
 PCT - Nat. Stg.
 PCT - Nat. Stg.
 PCT - Nat. Stg.
 371 - US from PCT as Foreign

DIV - Divisional
 DIV - Divisional

DIV - Divisional
 DIV -
Divisional
	 	Converted
 Converted

Nationalized
 Allowed

Pending
 Pending

Pending
 Pending

Pending
 Pending

Pending
 Not Yet Filed

Not Yet Filed