UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

OFFICE OF 

CHEMICAL SAFETY ANO 

POLLUTION PREVENTION 

MEMORANDUM 

Date: 22-SEP-2015 

Subject: Pyrimethanil: Acute and Chronic Aggregate Dietary (Food and Drinking Water) 

Exposure and Risk Assessment for the Proposed Uses on Cucumbers, Tomato 

Subgroup 8-1 OA, Lemon Subgroup 10-1 OB, Orange Subgroup 10-1 OA, Grapefruit 

Subgroup 10-lOC, Pome Fruit Group 11-10, Stone Fruit Group 12-12 Caneberry 

Subgroup 13-07A, and Bushberry Subgroup 13-07B. 

PC Code: 28820 I 

Decision Nos.: 492391 & 493505 

Petition Nos.: 4F829 I & 4E8302 

Risk Assessment Type: Dietary 

TXRNo.: NA 

MRID No.: NA 

DP No.: 0424861 

Registration No.: 438 13-32 

Regulatory Action: Section 3 

Case No.: 7059 

CAS No.: 53112-28-0 

40 CFR: §180.518 

From: George F. Kramer, Ph.D., Senior Chemist#' :!'¢." ~ Risk Assessment Branch 1 (RAB 1) 

Through: 

To: 

Health Effects Division (HED, 750~ {/_ 

bv ~ . Sheila Piper, Senior Chemist/ ~ ~ '. ;;;1,fr David E. Hrdy, Senior BiologistP twe 41.. yjfiR Dietary Exposure Science Advisory Council (DESAC 

HED (7509P) 

And 

Thurston G. Morton, Acting Branch Chief 

RAB 1/HED (7509P) 

Andrew Ertman/Barbara Madden, RM 05 

Marcel Howard/Hope Johnson, RM 21 

Registration Division (RD, 7505P) 

Executive Summary 

Aggregate (food+ water) acute and chronic dietary exposure and risk assessments were 

conducted for the general U.S. population and various population subgroups using the Dietary 

Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM-FCID) 

Version 3 .16. This software uses 2003-2008 food consumption data from the U.S. Department 

of Agriculture's (USDA's) National Health and Nutrition Examination Survey, What We Eat in 

America, (NHANES/WWEIA). The analyses were performed to support a Section 3 registration 

Page I of22 
Pyrimethanil Dietary Exposure and Risk Assessment DP# 424861 

request for use of the fungicide pyrimethanil [4,6-dimethyl-N-phenyl-2-pyrimidinamine] on 

cucumbers, tomato subgroup 8-1 OA, lemon subgroup 10-1 OB, orange subgroup 10-1 OA, 

grapefruit subgroup 10-1 OC, pome fruit group 11-10, stone fruit group 12-12 caneberry subgroup 

13-07 A, and bushberry subgroup l 3-07B. This memorandum was reviewed by two peer 

reviewers of the DESAC, per DESAC SOP 2012.1. 

Acute Dietary Exposure Results and Characterization 

The unrefined acute assessment assumed that pyrimethanil residues are present in all 

commodities at tolerance levels and that 100% of all crops are treated ( 100% CT). DEEM 

Version 7 .81 default processing factors were used to estimate residues in processed commodities, 

as available, and empirical processing factors were used for orange and apple juice. Drinking 

water was incorporated directly into the dietary assessment using the estimated drinking water 

concentrations (EDWCs) generated by with the Surface Water Concentration Calculator 

(SWCC) and Pesticide Root Zone Model-Ground Water (PRZM-GW) provided by the 

Environmental Fate Effects Division (EFED). 

Using the DEEM-FCID software, dietary risk at the 95th percentile of exposure is estimated at 

10% of the acute population-adjusted dose (aPAD) for the general U.S. population and 40% of 

the aPAD for children 1-2 years old, the population subgroup with the highest estimated acute 

dietary exposure. Therefore, the acute dietary risk assessment shows that for all included 

commodities plus drinking water, the acute dietary risk estimates are below HED's level of 

concern for the general popuJation and all population subgroups (i.e., <100% aP AD). 

Chronic Dietary Exposure Results and Characterization 

The unrefined chronic assessment assumed that pyrimethanil residues are present in all 

commodities at tolerance levels and that 100% of all crops are treated. DEEM Version 7 .81 

default processing factors were used to estimate residues in processed commodities, as available, 

and empirical processing factors were used for orange and apple juice. Drinking water estimates 

were incorporated directly into the chronic dietary assessment using the EDWC values generated 

by the SWCC surface water model. 

Using the DEEM-FCID software, dietary risk is estimated at 15% of the chronic populationadjusted dose (cPAD) for the general U.S. population and 80% of the cPAD for children 1to2 

years old, the population subgroup with the highest estimated chronic dietary exposure to 

pyrimethanil. The chronic dietary risk assessment shows that for all included commodities plus 

drinking water, the chronic dietary risk estimates are below HED's level of concern (i.e., <100% 

cPAD). 

Cancer Dietary Exposure Assessment 

A cancer dietary assessment was not conducted because pyrimethanil is classified as "not likely 

to be carcinogenic to humans at doses that do not alter rat thyroid hormone homeostasis." 

Pyrimethanil was previously classified as a Group C carcinogen, but newly submitted toxicology 

data have resulted in this change in cancer classification (TXR#0056151, J. Rowland, 23-DEC2012). 

Page 2 of22 
Pyrimethanil Dietary Exposure and Risk Assessment DP# 424861 

I. Introduction 

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic (non-cancer) assessments, the risk is expressed as a percentage of a maximum 

acceptable dose (i.e., the dose which HED has concluded will result in a no-observed adverseeffect level, NOAEL). This dose is referred to as the PAD. The PAD is equivalent to the point 

of departure (POD, NOAEL, LOAEL) divided by the required uncertainty factors (UFs). 

For acute and chronic (non-cancer) exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD for acute and non-cancer chronic assessment. References that discuss 

dietary risk assessments in more detail are available on the EPA/pesticides web site: "Available 

Information on Assessing Exposure from Pesticides, A User's Guide," 21-JUN-2000, web link: 

http://www.regulations.gov/#!documentDetail;D=EPA-HQ-OPP-2007-0780-0001. 

The most recent dietary risk assessment for pyrimethanil was conducted by J. Pyne (12-AUG2014; 0417165). 

II. Residue Information 

Pyrimethanil tolerances are published in 40 CFR § 180.518. 

Residues of Concern in Plants and Livestock: Table 1 is a summary of the HED Metabolism 

Assessment Review Committee (MARC) decisions concerning the residues of concern in plants, 

ruminants, and milk for tolerance expression and risk assessment purposes (J. Morales, 12-JAN2004; 0248001). 

Table 1. Residues of Concern in Plants and Ruminants. 

Matrix Residues of Concern 

For Risk Assessment For Tolerance Expression 

Plants Parent Only Parent Only 

Ruminant Parent + AEC614276 Parent + AEC614276 

Milk Parent + AEC614277 Parent + AEC614277 

Recommended Tolerances: The proposed new use to greenhouse-grown cucumbers is as a foliar 

application three times at 0. 70 lbs ail A with a maximum of 2.1 lbs ail A/season and a preharvest 

interval (PHI) of 1 day. The proposed new use to caneberries and bushberries is as a foliar 

application 2-4 times at 0.35-0.70 lbs ai/A with a maximum of 1.4 lbs ai/A/season and a PHI of 1 

day. No new data were submitted to support tolerances on tomato subgroup 8-1 OA, lemon 

subgroup 10-1 OB, pome fruit group 11-10, orange subgroup 10-1 OA, grapefruit subgroup l 0-

1 OC, and stone fruit group 12-12. The petitioner has requested that existing tolerances be 

expanded to their respective crop groups or crop subgroups. As part of the current petitions, 

HED recommends establishing the following tolerances: 

Cucumber .......................... .... .................... ........ ........... 1.5 ppm 

Fruit, citrus, group 10-10 ............................................... 10 ppm 

Fruit, pome, group 11-10 ............................................... 15 ppm 

Fruit, stone, group 12-12 ............................................... 10 ppm 

Tomato subgroup 8-IOA ............................................ 0.50 ppm 

Caneberry, subgroup 13-07 A ........................................ 15 ppm 

Bushberry, subgroup 13-07B .. ........ .... ........ ................. 8.0 ppm 

Page 3 of22 
Pyrimethanil Dietary Exposure and Risk Assessment DP# 424861 

Food Residues and processing factors used in the Acute and Chronic Analysis: The acute and 

chronic analyses assumed DEEM (ver. 7.81) default processing factors (as necessary), empirical 

processing factors for orange and apple juice, tolerance-level residues, and 100% CT for all 

commodities. The empirical processing factors for orange juice (0.007) and apple juice (0.35) 

can be found in D248001 (PP#s 2F6439 & 2F6480, J. Morales, 12-JAN-2004). 

The tolerance in 40 CFR §180.518(a)(1) for residues ofpyrimethanil in/on onion, bulb, subgroup 

3-07 A do not match the recommended tolerances from a previous assessment (Memo, Tyler el 

al., 22-MAY-2013; D389923). HED recommended for a tolerance of0.20 ppm for residues of 

pyrimethanil in/on onion, bulb, subgroup 3-07 A. Since the 40 CRF has a higher tolerance for 

residues of pyrimethanil in/on onion, bulb, subgroup 3-07 A, the 40 CFR tolerance of 2.0 ppm 

was used in this assessment to be consistent with the published limits until this revision is 

accepted. 

Fish: The USDA Pesticide Data Program (PDP) monitored pesticide residues in catfish in 2008, 

2009, and 2010. Over this 3-year period, PDP analyzed 1,479 samples of catfish for 

pyrimethanil residues. None of the samples contained detectable residues. As a result, residues 

in fish were not included in the assessment. 

III. Percent Crop Treated Information 

The acute and chronic analyses assumed that 100% of the crops were treated. 

IV. Drinking Water Data 

EFED studies indicated that pyrimethanil is expected to be moderately persistent in the 

environment. Aerobic metabolism is expected to be the major route of degradation for 

pyrimethanil in the environment. The only major degradate is 2-amino-4,6-dimethylpyrimidine. 

Although it may be less toxic than the parent, 2-arnino-4,6-dimethylpyrimidine is expected to be 

more mobile and more persistent in the environment than the parent. MARC recommended that 

parent and 2-amino-4,6-dimethylpyrimidine are the residues of concern for drinking water. 

EFED provided EDWCs estimated with the SWCC and PRZM-GW using the maximum 

application rate and number of applications, as there are no monitoring data available for use in 

the human health risk assessment (J. Wolf, 14-MA Y-2015; D422295). 

IR-4 has requested to expand the citrus, pome and stone fruit crops for the existing postharvest 

uses for PENBOTEC® 400 SC (EPA Reg. No. 43813-32). Based on the information provided, 

EFED considers the proposed post-harvest dip use of pyrimethanil as an indoor use that would 

pose minimal exposure to the environment, provided that release of the chemical and 

contaminated water are controlled. 

The screening level drinking water concentrations for combined residues of pyrimethanil (parent 

+ 2-amino-4,6-dimethylpyrimidine) in surface water are not expected to exceed 156 ppb for the 

peak 1-in-10-year concentration; 27.9 ppb for the 1-in-10-year annual mean concentration; and, 

21.3 ppb for the 30-year annual average concentration for the new uses or crop group expansion 

(assuming 2 crops per year 1

). The screening level drinking water concentrations for combined 

1 I crop per year- peak 68 μg/L: annual average = 18 μg/L, and 30 year average = 13 μg/L. 

Page 4 of22 
Pyrimethanil Dietary Exposure and Risk Assessment DP# 424861 

residues of pyrimethanil (parent + 2-amino-4,6-dimethylpyrimidine) in groundwater estimated 

with PRZM-GW are 128 ppb for the highest daily value and 11 7 ppb for the post-break-through 

average (Table 2). Cun-ent policy is for EFED to recommend the EDWCs for the water source 

with the highest EDWCs, which for pyrimethanil is surface water for acute exposure and 

groundwater for chronic exposure. However, due to generally low leaching (EDWCs and 

incomplete breakthrough) with 100-year simulation in groundwater, the surface water EDWCs 

are recommended for both acute and chronic exposure assessments. The EDWCs for the 

combined residues are presented below in Table 2. The models and their descriptions are 

available at the EPA internet site: http://www.epa.gov/oppefed I/models/water/. 

Ta ble 2. Surface Water and Groundwater EDWCs for Pyrimethanil Plus the Degradate (2-amino-4,6-

dimethylpyrimidine) for the Proposed New Uses and Crop Group Expansions for Scala® SC Fungicide 

(EPA Reg No. 264-788) Assuming the Maximum Aoolication Rate (3 or 6 applicat ons ~ 0.7 lb a.i./A/year). 

Standard Scenarios Model Application Rate I -in-I 0-Year 30-Year 

Peak Annual Mean Mean 

Surface Water #/lb a.i./A (ppb) 

Multiple Scenarios .. r swcc 3 @ 0.7/7 per crop 1569 27.9b 21.3c 

cycle/2 crop cycles 

3 @ 0.717 per crop 67.8d 17.SC 13.1 f 

cycle/ I crop cycles 

Highest 

Groundwater Daily Value Post-breakthrough Average 

FL Citrus PRZM-GW 

FL Potato 

• FL Strawberry (2 crop cycles). 

b PA Tomato (2 crops cycles). 

c CA Grape (2 crops cycles). 

d FL Strawberry (I crop cycle). 

c PA Apple (I crop cycle). 

r GA Peach (I crop cycle). 

3 @ 0.7/7 per crop 128 117 

cvcle/2 crop cycles 

3@ 0.7/7 per crop 25.2 22.7 

cycle/2 crop cycles 

Jn this assessment, the l-in-10-year annual average surface water concentration (27.9 ppb) and 

the 1-in-l 0-year acute peak surface water concentrations (156 ppb) were used for chronic and 

acute dietary exposure assessments, respectively. 

V. DEEM-FCID Program and Consumption Information 

Pyrimethanil acute and chronic dietary exposure assessments were conducted using the DEEMFCID, Version 3.16, which incorporates 2003-2008 consumption data from USDA's 

NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 

individuals over two non-consecutive survey days. Foods "as consumed" (i.e., apple pie) are 

linked to EPA-defined food commodities (i.e., apples, peeled fruit - cooked; fresh or N/S; baked; 

or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files 

developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data 

are averaged for the entire U.S. population and within population subgroups, but for acute 

exposure assessment are retained as individual consumption events. Based on analysis of the 

2003-2008 NHANES/WWEIA consumption data, which took into account dietary patterns and 

survey respondents, HED concluded that it is most appropriate to report risk for the following 

population subgroups: the general U.S. population, all infants (<l year old), children 1-2 years 

Page 5 of22 
Pyrimethanil Dietary Exposure and Risk Assessment DP# 424861 

old, children 3-5 years old, children 6-1 2 years old, youth 13-1 9 years old, adults 20-49 years 

old, females 13-49 years old, and adults 50-99 years old. 

For the chronic dietary exposure assessment, an estimate of the residue level in each food or 

food-form (i.e., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form. The resulting residue consumption 

estimate for each food/food form is summed with the residue consumption estimates for all other 

food/food forms on the commodity residue list to arrive at the total average estimated exposure. 

Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure 

is performed for each population subgroup. 

For acute exposure assessments, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or "matched" in multiple random pairings with residue values 

and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aP AD on both a user (i.e., those who reported eating relevant 

commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 

commodities as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for all levels of refinements. However, for unrefined and partially 

refined assessments, significant differences in user vs. per capita exposure and risk are identified 

and noted in the risk assessment. 

VI. Toxicological Information 

The toxicology endpoints and decisions made by the HIARC concerning dietary exposure are 

summarized in Table 3. 

Based on toxicological considerations (evaluated by HIARC) and the residue assumptions used 

in the dietary analyses (evaluated by the risk assessment team; RAB l/HED), it was concluded 

that the FQPA Safety Factor should be reduced to 1 X when assessing dietary exposure to 

pyrimethanil. 

Page 6 of22 
Pyrimethanil Dietary Exposure and Risk Assessment DP# 424861 

Ta ble 3. Summa ry of Tox icological Doses a nd Endpoints for Pyrimetha nil fo r Use in Dieta ry Exposure Risk 

Assessments. 

Exposure/ POD Uncerta inty/FQPA RID, PAD, Level of Study and Toxicological Effects Scenario Safety Factors Concern 

Acute Dietary NOAEL= UFA= IOX Acute RID = 0.45 Developmenta l Tox icity - Rabbit: 

(Females 13- 45 UFH = IOX mg/kg/day LOAEL = 300 mg/kg/day based on 

49 years of mg/kg/day FQPA SF = IX increases in fetuses with 13 thoracic 

age) aPAD = 0.45 vertebrae and 13 pairs of ribs. 

mg/kg/day 

Acute Dietary NOAEL = UFA = !OX Acute RID = I Acute Neurotoxicity- Rat: 

(General 100 UFH = IOX mg/kg/day LOAEL = I 000 mg/kg/day based on 

Popu lation, mg/kg/day FQPA SF= IX decreased motor activity, atax ia, 

including decreased body temperature, hind 

Infants and limb grip strength, and dilated pupils. 

Children) 

Chronic NOAEL = UFA = IOX Chronic RfD = 0.17 Chronic Toxicity - Ra t: 

Dietary (All 17 UFH = IOX mg/kg/day LOAEL = 221 mg/kg/day based on 

Populations) mg/kg/day FQPA SF = lX decreased body weight gains; 

cPAD = 0.17 increased serum cholesterol and 

mg/kg/day GGT, increased relative liver/body 

weight ratios, necropsy and 

histopathological findings in the liver 

and thyroid. 

Cancer (oral, dennal, In accordance with the EPA's Final Guidelines for Carcinogen Risk Assessment 

inhalation) (March 2005), the CARC classified pyrimethani l as "not likely to be ca rcinogenic 

to huma ns a t doses tha t do not alter ra t thyroid hormone homeostasis" (TXR# 

005615 1, J. Rowland, 23-DEC-2012). 

Pomt of departure (POD) = A data point or an estimated point that is derived from observed dose-response data and 

used to mark the beginning of extrapolation to determine risk associated with lower environmentally re levant human 

exposures. NOAEL = no-observed adverse-effect level. LOAEL = lowest-observed adverse-effect level. UF = 

uncertainty factor. UFA = extrapolation from animal to human (intraspecies). UFH = potential variation in 

sensitivity among members of the human population (interspecies). FQPA SF = FQPA Safety Factor. PAD= 

population-adjusted dose (a = acute, c = chronic). RfD = reference dose. MOE = margin of exposure. 

VII. Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 

100% of the aPAD or cPAD, respectively. The fo llowing paragraphs are summaries of the 

DEEM-FCID (ver. 3. 16) acute and chronic exposure analyses. 

Acute and chronic aggregate (food+ water) analyses were performed using DEEM-FCID 

estimating the dietary exposure of the U.S. population and various population subgroups. The 

results are summarized in Table 4 below for acute and chronic analyses. 

The resulting acute food and drinking water risk estimates are not of concern to HED (< I 00% 

aPAD) at the 95111 percentile of the exposure distribution for the U.S. general population and all 

population subgroups (:S40% aP AD); the most highly exposed population subgroup is children 1-

2 years old. The resulting chronic food and drinking water risk estimates are not of concern to 

HED (<100% cPAD) for U.S. general population and all population subgroups (:S80% cPAD); 

the most highly exposed population subgroup is children 1-2 years old. 

Page 7 of22 
Pyrimethanil Dietary Exposure and Risk Assessment DP# 424861 

Table 4. Summa ry of Dietary (f ood and Drinking Water) Exposure and Risk fo r Pyrimethanil. * 

Acute Dietary Chronic Dietary Cancer (95th Percentile) 

Population Subgroup Dietary Dietary Dietary 

Exposure %aPAD* Exposure %cPAD* Exposure Risk 

(mg/kg/day) (mg/kg/day) (mg/kg/day) 

General U.S. Population 0.105357 11 0.024977 15 

All In fants (< I year old) 0.369251 37 0.090488 53 

Children 1-2 years old 0.401904 40 0.136305 80 

Ch ildren 3-5 years old 0.254739 25 0.082594 49 

Children 6-1 2 years old 0.137476 14 0.038145 22 NIA NIA 

Youth 13- 19 years old 0.065147 6.5 0.016025 9.4 

Adults 20-49 years old 0.060961 6.1 0.0 14440 8.5 

Adults 50-99 vears old 0.063998 6.4 0.017030 10 

Females 13-49 years old 0.063604 14 0.015479 9.1 

*Population subgroup with the highest exposure and risk is in bold type. The aPAD for fema les 13-49 years 

of age is 0.45 mg/kg/day: aP AD for general population is I mg/kg/day. 

VIII. Characterization of Inputs/Outputs 

The acute and chronic dietary exposure and risk estimates are conservative since they assume 

that I 00% of crops are treated with pyrimethanil and that residues are present at tolerance levels. 

In addition, drinking water exposure estimates were based on screening level estimates generated 

by the PRZMIEXAMS water model. Dietary exposure estimates could be refined through the 

use of anticipated residues and percent crop treated data, as well as refined estimated drinking 

water concentrations. However, since estimated exposures and risks using conservative 

assumptions are well below HED's level of concern, such refinement is not warranted. 

IX. Conclusions 

The unrefined dietary exposure assessment using DEEM-FCID indicates that both acute and 

chronic dietary food + drinking water exposures to pyrimethanil are below HED's level of 

concern for this pesticide. The resulting acute food and drinking water risk estimates are <100% 

aPAD at the 95111 percenti le of the exposure for the U.S. general population and all population 

subgroups (::;40% aP AD); the most highly exposed population subgroup is children 1-2 years 

old. The chronic food and drinking water risk estimates are <100% cPAD for U.S. general 

population and all population subgroups (:S80% cPAD); the most highly exposed population 

subgroup is children 1-2 years old. 

X. List of Attachments 

Attachment 1: Acute Food plus Water Residue Input File 

Attachment 2: Acute Results (Food plus Water) File 

Attachment 3: Chroni c Food plus Water Residue Input File 

Attachment 4: Chronic Results (Food plus Water) File 

Attachment 5: Acute Results (Food only) File 

Attachment 6: Chronic Results (Food only) File 

cc: G. Kramer 

RD!: DE SAC Reviewers (28-MA Y-2015) 

G. F. Kramer:S I 0957:PY-S:(703)305-5079:7509P:RAB I 

Page 8 of22 
Pyrimethanil Dietary Exposure and Risk Assessment DP# 424861 

Attachment 1: DEEM-FCID Acute Residue File - Food plus Water 

Filename : C: \Users\gkramer\Documents\Gk\#Pyrimethanil\Pyrimethanilacute . R08 

Chemical : Pyrimethanil 

RfO(Chronic) : . 17 mg/kg bw/day NOEL(Chronic) : 17 mg/kg bw/day 

RfO(Acute) : 1 mg/kg bw/day NOEL(Acute) : 100 mg/kg bw/day 

Date created/last modified : 05-28-2015/09 : 55 :51 Program ver. 3 . 16, 03-08-d 

Comment : FQPA SF lX for all endpoints; cPAD for all popul ations is 0 . 17 mg/kg/day 

EPA 

Code 

Crop 

Grp Commodity Name 

0101168000 lAB Ginseng, dried 

0103015000 lCO Arrowroot , flour 

Full comment : 0284001 

0103015001 lCO Arrowroot , flour-babyfood 

Fu l l comment : 0284001 

0103017000 lCO Artichoke, Je rusalem 

Full comment : 0284001 

0103082000 lCO Cassava 

Full comment : 0284001 

0103082001 lCO Cassava-babyfood 

Full comment : D284001 

0103139000 lCO Oasheen, corm 

Fu ll comment : 0284001 

0103166000 lCO Ginger 

Full comment : 0284001 

0103166001 lCD Ginger- babyfood 

Full comment : 0284001 

0103 167000 lCO Ginger, dried 

Full comment : 0284001 

0103296000 lC Potato, chips 

Full comment : 0284001 

01 03297000 lC Potato, dry (granules/ flakes) 

Full comment : 0284001 

0103297001 lC Potato, dry (granules/ flakes) - b 

Full comment : 0284001 

0103298000 lC Potato, flour 

Full comment : 0284001 

0103298001 lC Potato, flour-babyfood 

Full comment : D284001 

0103299000 lC Potato, tuber, w/peel 

Full comment : 0284001 

0103299001 lC Potato, tuber, w/peel-babyfood 

Full comment : 0284001 

0103300000 lC Potato, tuber, w/o peel 

Full comment : 0284001 

0103300001 lC Potato, tuber, w/o peel-babyfood 

Full comment : 0284001 

0103366000 lCO Sweet potato 

Full comment : 0284001 

0103366001 lCD Sweet potato-babyfood 

Full comment : 0284001 

0103371000 lCD Tanier, corm 

Full comment : D284001 

0103387000 lCO Turmeric 

Fu ll comment : 0284001 

0103406000 lCO Yam, true 

Full comment : 0284001 

0103407000 lCD Yam bean 

Full comment : D284001 

0301165000 3A Garlic, bulb 

0301165001 3A Garlic, bulb- babyfood 

0301237000 3A Onion, bulb 

Full comment : 0284001 

0301237001 3A Onion, bulb- babyfood 

Full comment : 0284001 

0301238000 3A Onion , bulb, dried 

Full comment: 0284001 

0301238001 3A Onion, bulb, dried-babyfood 

Def Res 

(ppmJ 

1 . 500000 

0 . 050000 

0 . 050000 

0 . 050000 

0 . 050000 

0 . 050000 

0 . 050000 

0 . 050000 

0 . 050000 

0 . 050000 

0 . 050000 

0 . 050000 

0 . 050000 

0 . 050000 

0 . 050000 

0 . 050000 

0 . 050000 

0 . 050000 

0 . 050000 

0 . 050000 

0 . 050000 

0 . 050000 

0 . 050000 

0 . 050000 

0 . 050000 

2 . 000000 

2 . 000000 

2 . 000000 

2 . 000000 

2 . 000000 

2 . 000000 

Page 9 of22 

Adj . Factors Comment 

#1 #2 

1. 000 1. 000 

1 . 000 1 . 000 028400 

1 . 000 1. 000 028400 

1 . 000 1. 000 028400 

1 . 000 1 . 000 028400 

1 . 000 1 . 000 028400 

1 . 000 1 . 000 D28400 

1 . 000 1 . 000 028400 

1 . 000 1 . 000 028400 

1 . 000 1 . 000 028400 

1 . 000 1 . 000 028400 

6 . 500 1 . 000 028400 

6 . 500 1 . 000 028400 

6 . 500 1 . 000 028400 

6 . 500 1 . 000 028400 

1 . 000 1 . 000 028400 

1 . 000 1 . 000 028400 

1 . 000 1 . 000 028400 

1 . 000 1 . 000 028400 

1 . 000 1. 000 028400 

1 . 000 1 . 000 028400 

1 . 000 1 . 000 028400 

1 . 000 1 . 000 028400 

1 . 000 1 . 000 028400 

1 . 000 1 . 000 D28400 

1. 000 1. 000 

1. 000 1. 000 

1 . 000 1 . 000 028400 

1 . 000 1 . 000 028400 

9 . 000 1 . 000 028400 

9 . 000 1 . 000 028400 
Pyrimethanil Dietary Exposure and Risk Assessment DP# 42486 1 

Full comment : 0284001 

0301338000 3A Shallot, bulb 2 . 000000 1 . 000 1 . 000 

0302103000 38 Chive , fresh leaves 3 . 000000 1 . 000 1 . 000 

0302198000 38 Leek 3 . 000000 1 . 000 1 . 000 

0302239000 38 Onion, green 3 . 000000 1 . 000 1 . 000 02S 400 

Full comment : 0284001 

0302338500 38 Shallot, fresh leaves 3 . 000000 1 . 000 1 . 000 

080137 4000 SA Tomatillo 0 .500000 1 . 000 1 . 000 

0801375000 SA Tomato 0 . 500000 1 . 000 1 . 000 02S400 

Full comment : 02S4001 

0801375001 SA Tomato-baby food 0 . 500000 1 . 000 1 . 000 028400 

Full comment : 0284001 

0801376000 SA Tomato, paste 0 . 500000 5 . 400 1 . 000 028400 

Full comment : 0284001 

0801376001 BA Tomato , paste-babyfood 0 . 500000 5 . 400 1 . 000 028400 

Full comment : 0284001 

OS01377000 SA Tomato , puree 0 . 500000 3 . 300 1 . 000 028400 

Full comment : 02S4001 

OS01377001 SA Tomato , puree- babyfood 0 . 500000 3 . 300 1 . 000 028400 

Full comment : 02S 4001 

OS01378000 BA Tomato , dried 0 . 500000 14 . 300 1 . 000 028400 

Full comment : 02S 4001 

0801378001 BA Tomato, dried- baby food 0 . 500000 14 . 300 1 . 000 02B400 

Full comment : 02B4001 

0801379000 SA Tomato, juice 0 . 500000 1 . 500 1 . 000 02S400 

Full comment : 0284001 

OS013SOOOO SA Tomato , Tree 0 . 500000 1 . 000 1.000 

0902135000 98 Cucumber 1 . 500000 1 . 000 1 . 000 

1001106000 lOA Citron 10 . 000000 1 . 000 1 . 000 028400 

Full comment : 02B4001 

1001107000 lOA Citrus hybrids 10 . 000000 1 . 000 1 . 000 D28400 

Full comment : 02B4001 

lOOllOSOOO lOA Citrus, oil 150 . 000000 1 . 000 1 . 000 D28400 

Full comment : D2B 4001 

1001240000 lOA orange 10 . 000000 1 . 000 1 . 000 D2S400 

Full comment : 02S4001 

1001241000 lOA Orange , juice 10 . 000000 0 . 007 1.000 02S400 

Full comment : D284001 

1001241001 lOA Orange , juice- baby food 10 . 000000 0 . 007 1 . 000 D28400 

Full comment : 0284001 

1001242000 lOA Orange , peel 10 . 000000 1 . 000 1 . 000 02S400 

Full comment : 0284001 

1001369000 lOA Tangerine 10 . 000000 1 . 000 1 . 000 02S400 

Full comment : 02S4001 

1001370000 l OA Tangerine , j uice 10 . 000000 2 . 300 1 . 000 02S 400 

Full comment : 02S4001 

1002197000 lOB Kumquat 10 . 000000 1 . 000 1 . 000 02S 400 

Full comment : 02B4001 

1002199000 lOB Lemon 10 . 000000 1 . 000 1 . 000 SE7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1002200000 108 Lemon, juice 10 . 000000 2 . 000 1 . 000 SE7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1002200001 108 Lemon , juice- baby food 10 . 000000 2 . 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1002201000 lOB Lemon , peel 10 . 000000 1 . 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1002206000 108 Lime 10 . 000000 1 . 000 1 . 000 D2B400 

Full comment : D2B4001 

1002207000 lOB Lime , juice 10 . 000000 2 . 000 1 . 000 D2B400 

Full comment : D2S4001 

1002207001 lOB Lime , juice- baby food 10 . 000000 2 . 000 1 . 000 D2B400 

Full comment : D2B4001 

10031SOOOO lOC Grapefruit 10 . 000000 1 . 000 1 . 000 02S400 

Full comment : 0284001 

1003181000 lOC Grapefruit , juice 10 . 000000 2 . 100 1 . 000 028400 

Full comment : 0284001 

1003307000 lOC Pummelo 10 . 000000 1 . 000 1 . 000 028400 

Full comment : 0284001 

1100007000 11 Apple, fruit with peel 15 . 000000 1 . 000 1 . 000 DPH 34 

Full comment : DP# 3472 4B 

llOOOOSOOO 11 Apple , peeled f rui i: 15 . 000000 1 . 000 1 . 000 DP# 34 

Page 10 of22 
Py rimethanil Dietary Exposure and Risk Assessment DP# 424861 

Ful l comment : DP# 3472 48 

1100008001 11 Apple , peeled frui t - babyfood 15 . 000000 1 . 000 1 . 000 DP# 34 

Full comment : DP# 347248 

1100009000 11 Apple , dried 15 . 000000 8 . 000 1 . 000 DP# 34 

Full comment : DP# 3472 48 

1100009001 11 Apple , dried-ba byfood 15 . 000000 8 . 000 1. 000 DP# 34 

Full comment : DP# 3472 48 

1100010000 11 Apple , juice 15 . 000000 0 . 350 1 . 000 DPli 34 

Full comment : DP# 3472 48 

1100010001 11 Apple , j uice-babyfood 15 . 000000 0 . 350 1 . 000 DPll 34 

Full comment : DP# 347248 

1100011000 11 Apple , sauce 15 . 000000 1 . 000 1 . 000 DP # 34 

Full comment : DPli 34 7248 

1100011001 11 Appl e , sauce-babyfood 15 . 000000 1 . 000 1 . 000 DP li 34 

Full comment : DP# 3472 48 

1100129000 11 Crabapple 15 . 000000 1 . 000 1 . 000 DP# 34 

Fu l l comment : DP# 3472 48 

1100210000 11 Loquat 15 . 000000 1 . 000 1 . 000 DP# 34 

Full commen t : DP# 3472 48 

1100266000 11 Pear 15 . 000000 1 . 000 1 . 000 DP# 34 

Full comment : DP# 347248 

1100266001 11 Pear-bab yf ood 15 . 000000 1 . 000 1 . 000 DP# 34 

Full comment : DP# 347248 

1100267000 11 Pear, dried 15 . 000000 6 . 250 1 . 000 DP# 34 

Full comment : DP # 347248 

1100268000 11 Pear, juice 15 . 000000 1 . 000 1 . 000 DP# 34 

Full comment : DP# 347248 

1100268001 11 Pear, juice-babyfood 15 . 000000 1.000 1 . 000 DP # 34 

Fu l l comment : DP# 3472 48 

1100310000 11 Quince 15 . 000000 1 . 000 1 . 000 DP# 34 

Full comment : DP# 3472 48 

1201090000 12A Cherry 10 . 000000 1 . 000 1 . 000 8E7353 

Fu l l comment : 8E7353 Proposed Tolerance 2009 

1201090001 12A Cherry- bab yfood 10 . 000000 1 . 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1201091000 12A Cherry, juice 10 . 000000 1 . 500 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1201091001 12A Cherry, juice-baby food 10 . 000000 1 . 500 1 . 000 8E7353 

Full comment : 8E7353 Propos ed Toler ance 2009 

1202012000 128 Apricot 10 . 000000 1 . 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1202012001 128 Apricot- baby food 10 . 000000 1 . 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1202013000 12B Apricot, dried 10 . 000000 6. 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1202014000 128 Apricot, juice 10 . 000000 1 . 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolera nce 2009 

1202014001 12B Apricot, juice- baby food 10 . 000000 1 . 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1202230000 12B Nect arine 10 . 000000 1 . 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1202260000 12B Peach 10 . 000000 1 . 000 1 . 000 8E7353 

Ful l comment : 8E7353 Proposed Tol erance 2009 

1202260001 12B Peach- baby food 10 . 000000 1 . 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tol e r ance 2009 

1202261000 12B Peach, dried 10 . 000000 7 . 000 1 . 000 8E7353 

Fu l l comment : 8E7353 Proposed Tol e r ance 2009 

1202261001 128 Peach, dried - babyf ood 10 . 000000 7 . 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1202262000 12B Peach, juice 10 . 000000 1 . 000 1 . 000 8E7353 

Full comment. : 8E7353 Proposed Tolerance 2009 

1202262001 12B Peach, j uice- babyfood 10 . 000000 1 . 000 1 . 000 8E7353 

Full comment : 8E7353 Pr oposed Tolerance 2009 

1203285000 12C Plum 10 . 000000 1 . 000 1 . 000 8E7353 

Full comment : 8E7353 Pr oposed Tolerance 2009 

1203285001 12C Plum-baby food 10 . 000000 1 . 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1203286000 12C Plum, prune , fresh 10 . 000000 1 . 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tol erance 2009 

1203286001 12C Plum, prune , fresh-babyfood 10 . 000000 1 . 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

Page 11 of 22 
Pyrimethanil Dietary Exposure and Risk Assessment DP# 424861 

1203287000 12C Plum, prune , dried 10 . 000000 5 . 000 1 . 000 8E7353 

Full comment : 8£7353 Proposed Tolerance 2009 

1203287001 12C Plum, prune , dried-baby food 10 . 000000 5 . 000 1 . 000 8E7353 

Full comment : 8£7353 Proposed Tolerance 2009 

1203288000 12C Plum, prune , juice 10 . 000000 l. 400 1 . 000 8E7353 

Full comment : 8£7353 Proposed Tolerance 2009 

1203288001 12C Plum, prune , j uice- babyfood 10 . 000000 1. 400 1 . 000 8£7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1301055000 13A Blackberry 15 . 000000 1 . 000 1 . 000 

1301056000 13A Blackberry, juice 15 . 000000 1.000 1 . 000 

1301056001 13A Blackberry, juice-babyfood 15 . 000000 1 . 000 1 . 000 

1301058000 13A Boysenberry 15 . 000000 1 . 000 1 . 000 

1301208000 13A Loganberry 15 . 000000 1 . 000 1 . 000 

1301320000 13A Raspberry 15 . 000000 1 . 000 1 . 000 

1301320001 13A Raspberry-babyfood 15 . 000000 1 . 000 1 . 000 

1301321000 13A Raspberry, juice 15 . 000000 1 . 000 1 . 000 

1301321001 13A Raspberry, juice- babyfood 15 . 000000 1 . 000 1 . 000 

1302057000 13B Blueberry 8 . 000000 1 . 000 1 . 000 

1302057001 13B Blueberry-baby food 8 . 000000 1 . 000 1 . 000 

1302136000 13B Currant 8 . 000000 1 . 000 1 . 000 

1302137000 13B Currant, dried 8 . 000000 1 . 000 1 . 000 

1302149000 13B Elderberry 8 . 000000 1 . 000 1 . 000 

1302174000 13B Gooseberry 8 . 000000 1 . 000 1 . 000 

1302191000 13B Huckleberry 8 . 000000 1 . 000 1 . 000 

1304175000 130 Grape 5 . 000000 1 . 000 1 . 000 028400 

Full comment : 0284001 

1304176000 130 Grape , juice 5 . 000000 1 . 200 1 . 000 028400 

E'ull comment : 0284001 

1304176001 130 Grape , juice-babyfood 5 . 000000 1 . 200 1 . 000 028400 

Full comment : 0284001 

1304179000 130 Grape , wine and sherry 5 . 000000 1 . 000 1 . 000 028400 

Full comment : 0284001 

1307130000 13G Cranberry 3 . 000000 1 . 000 1 . 000 

1307130001 13G Cranberry-babyfood 3 . 000000 1.000 1 . 000 

1307131000 13G Cranberry, dried 3 . 000000 1 . 000 1 . 000 

1307132000 13G Cranberry, juice 3 . 000000 1 . 100 1 . 000 

1307132001 13G Cranberry, juice-babyfood 3 . 000000 1 . 100 1 . 000 

1307359000 13G Strawberry 3 . 000000 1 . 000 1 . 000 028400 

Full comment : 0284001 

1307359001 13G Strawberry-babyfood 3 . 000000 1 . 000 1 . 000 028400 

Full comment : 0284001 

1307360000 13G Strawberry, juice 3 . 000000 1 . 000 1 . 000 028400 

Full comment : 0284001 

1307360001 13G Strawberry, juice- baby food 3 . 000000 1 . 000 1 . 000 028400 

Full comment : 0284001 

1400003000 14 Almond 0 . 200000 1 . 000 1 . 000 028400 

Full comment : 0284001 

1400003001 14 Almond-baby food 0 . 200000 1 . 000 1 . 000 028400 

Full comment : 0284001 

1400004000 14 Almond , oil 0 . 200000 1 . 000 1 . 000 028400 

Full comment : 0284001 

1400004001 14 Almond , oil- babyfood 0 . 200000 1 . 000 1 . 000 028400 

Full comment : 0284001 

1400282000 14 Pistachio 0 . 200000 1 . 000 1 . 000 

3100044000 31 Beef, meat 0 . 010000 1 . 000 1 . 000 028400 

Full comment : 0284001 

3100044001 31 Beef, meat-babyfood 0 . 010000 1 . 000 1 . 000 028400 

Full comment : 0284001 

3100045000 31 Beef, meat , dried 0 . 010000 1 . 920 1 . 000 028400 

Full comment : 0284001 

3100046000 31 Beef, meat byproducts 0 . 010000 1.000 1 . 000 028400 

Full comment : 0284001 

3100046001 31 Beef, meat byproducts-babyfood 0 . 010000 1 . 000 1 . 000 028400 

Full comment : 0284001 

3100047000 31 Beef, fat 0 . 010000 1 . 000 1 . 000 028400 

Full comment : 0284001 

3100047001 31 Beef, fat-baby food 0 . 010000 1 . 000 1 . 000 028400 

Full comment : 0284001 

3100048000 31 Beef, kidney 2 . 500000 1 . 000 1 .000 DP ff 34 

Full comment : DP ff 347248 

3100049000 31 Beef, liver 0 . 010000 1 . 000 1 . 000 028400 

Page 12of22 
Pyrimethanil Dietary Exposure and Risk Assessment DP# 424861 

Full comment : D284001 

3100049001 31 Beef, liver- babyfood 0 . 010000 1 . 000 1 . 000 D28400 

Full comment : D284001 

3200169000 32 Goat , meat 0 . 010000 1 . 000 1 . 000 D28400 

Full comment : D284001 

3200170000 32 Goat, meat byproducts 0 . 010000 1 . 000 1 . 000 D28400 

Full comment : D284001 

3200171000 32 Goat , fat 0 . 010000 1 . 000 1 . 000 D28400 

Full comment : D284001 

3200172000 32 Goat , kidney 2 . 500000 1 . 000 1 . 000 DP# 34 

Full comment : DP# 347248 

3200173000 32 Goat , liver 0 . 010000 1 . 000 1.000 D28400 

Full comment : 0284001 

3300189000 33 Horse , meat 0 . 010000 1 . 000 1.000 D28400 

Full comment : D284001 

3500339000 35 Sheep, meat 0 . 010000 1 . 000 1 . 000 D28400 

Full comment : D284001 

3500339001 35 Sheep, meat-baby food 0 . 010000 1 . 000 1 . 000 D28400 

Full comment : D284001 

3500340000 35 Sheep, meat byproducts 0 . 010000 1 . 000 1 . 000 028400 

Full comment : D284001 

3500341000 35 Sheep, fat 0 . 010000 1 . 000 1 . 000 D28400 

Full comment : D284001 

3500341001 35 Sheep, fat-babyfood 0 . 010000 1 . 000 1 . 000 D28400 

Full comment : D284001 

3500342000 35 Sheep, kidney 2 . 500000 1 . 000 1 . 000 DP# 34 

Full comment : DP!I 347248 

3500343000 35 Sheep, liver 0 . 010000 1 . 000 1 . 000 D28400 

Full comment : D284001 

3600222000 36 Milk , fat 0 . 050000 1 . 000 1 . 000 DP# 34 

Full comment : DP# 347248 

3600222001 36 Milk , fat-baby food/ i nfant formu 0 . 050000 1 . 000 1 . 000 DP# 34 

Full comment : DP# 347248 

3600223000 36 Milk, nonfat solids 0 . 050000 1 . 000 1 . 000 DP# 34 

Full comment : DP# 347248 

3600223001 36 Milk , nonfat solids-baby food/in 0 . 050000 1 . 000 1 . 000 DP!I 34 

Full comment : DP# 347248 

3600224000 36 Milk, water 0 . 050000 1 . 000 1 . 000 DP# 34 

Full comment : DP# 347248 

3600224001 36 Milk , water- babyfood/infant form 0 . 050000 1 . 000 1 . 000 DP# 34 

Full comment : DPll 347248 

3600225001 36 Milk , sugar (lactose) - baby food/ 0 . 050000 1 . 000 1 . 000 DP# 34 

Full comment : DP!t 347248 

8601000000 86A Water, direct, all sources 0 . 156000 1 . 000 1 . 000 

8602000000 868 Water, indirect, all sources 0 . 156000 1 . 000 1 . 000 

9500023000 0 Banana 0 . 100000 1 . 000 1 . 000 

9500023001 0 Banana-babyfood 0 . 100000 1 . 000 1 . 000 

9500024000 0 Banana , dried 0 . 100000 3 . 900 1 . 000 

9500024001 0 Banana , dried- babyfood 0 . 100000 3 . 900 1 . 000 

9500177000 0 Grape , leaves 5 . 000000 1 . 000 1.000 D28400 

Full comment : D284001 

9500178000 0 Grape , raisin 8 . 000000 1 . 000 1 . 000 028400 

Full comment : D284001 

9500283000 0 Plantain 0 . 100000 1 . 000 1 . 000 

9500284000 0 Plantain, dried 0 . 100000 3 . 900 1 . 000 

9500289000 0 Pomegranate 5 . 000000 1 . 000 1 . 000 

Page 13 of22 
Pyrimethanil Dietary Exposure and Risk Assessment DP# 424861 

Attachment 2: DEEM-FCID Acute Exposure and Risk Estimates - Food plus Water 

US EPA 

DEEM-FCID ACUTE Analysis for PYRIMETHANIL 

Residue file : Pyrimethanilacute . R08 

Analysis Date : 05-28-2015/11 : 07 : 24 Residue 

NOEL (Acute) = 100 . 000000 mg/kg body- wt/day 

RAC/FF intake sununed over 24 hours 

Ver . 3.18, 03 - 08 - d 

NHANES 2003 - 2008 2- Day 

Adjustment factor #2 used . 

file dated : 05- 28 - 2015/09 : 55 : 51 

Run Comment : " FQPA SF lX for all endpoints; cPAD for all populations is 0 . 17 m 

g/kg/day" 

=============================================================================== 

Summary calculations--per capita : 

95th Percentile---- 99th Percentile---- ---99 . 9th Percentile----

Exposure % aRfD MOE Exposure % aRf D MOE Exposure % aRfD MOE 

---------- ------- -------- ---------- ------- -------- ---------- ------- -------- Total us Population: 

10 .54 949 0 . 241985 24 . 20 413 0 . 518749 51 . 87 192 

All Infants: 

0 . 369251 36 . 93 270 0 . 556543 55 . 65 179 0 . 730604 73 . 06 136 

Children 1-2 : 

0 . 401904 40 . 19 248 0 . 623436 62 . 34 160 0 . 983385 98 . 34 101 

Children 3- 5 : 

0 . 254739 25 . 47 392 0 . 366443 36 . 64 272 0 . 560416 56 . 04 178 

Children 6-12 : 

0 . 137476 13 . 75 727 0 . 234474 23 . 45 426 0 . 380739 38 . 07 262 

Youth 13- 19 : 

0 . 065147 6 . 51 1534 0 . 121471 12 . 15 823 0 . 260931 26 . 09 383 

Adults 20-49 : 

0 . 060961 6 . 10 1640 0 . 105701 10 . 57 946 0 . 196827 19 . 68 508 

Adults 50- 99 : 

0 . 063998 6 . 40 1562 0 . 100934 10 . 09 990 0 . 179775 17 . 98 556 

Female 13- 49 : 

0 . 063604 6 . 36 1572 0 . 108084 10 . 81 925 0 . 235738 23 . 57 424 

Page 14 of22 
Pyrimethanil Dietary Exposure and Risk Assessment DP# 424861 

Attachment 3: DEEM-FCID Chronic Residue File - Food plus Water 

Filename : C: \Users\gkramer\Documents\Gk\ff Pyrimethanil\Pyrimethanilchronic . R08 

Chemical : Pyrimethanil 

RfD(Chronic) : . 17 mg/kg bw/day NOEL(Chronic) : 17 mg/kg bw/day 

RfD(Acute) : 1 mg/kg bw/day NOEL(Acute) : 100 mg/kg bw/day 

Date created/last modi fied : 05-28-2015/09 : 57 : 00 Program ver. 3 . 16, 03-08-d 

Comment : FQPA SF lX for all endpoints; cPAD for all populations is 0 . 17 mg/kg/day 

EPA 

Code 

Crop 

Grp Commodity Name 

Def Res 

(ppm) 

Adj . Factors Comment 

#1 #2 

0101168000 lAB Ginseng , dried 

0103015000 lCD Arrowroot, flour 

1 . 500000 1 . 000 1 . 000 

0 . 050000 1 . 000 1 . 000 028400 

Full comment : 0284001 

0103015001 lCO Arrowroot , flour- babyfood 

Full comment : 0284001 

0103017000 lCO Artichoke , Jerusalem 

0 . 050000 1 . 000 1 . 000 028400 

0 . 050000 1 . 000 1 . 000 028400 

Full comment : 0284001 

0103082000 lCO Cassava 0 . 050000 1 . 000 1 . 000 028400 

Full comment : 0284001 

0103082001 lCD Cassava-babyfood 

Full comment : 0284001 

0103139000 lCD Dasheen, corm 

Full comment : 0284001 

0103166000 lCD Ginger 

0 . 050000 1 . 000 1 . 000 028400 

0 . 050000 1 . 000 1 . 000 028400 

0 . 050000 1 . 000 1 . 000 028400 

Full comment : 0284001 

0103166001 lCO Ginger-babyfood 

Full comment : 0284001 

0 . 050000 1 . 000 1 . 000 028400 

0103167000 lCO Ginger, dried 0 . 050000 

Full comment : 0284001 

0103296000 lC Potato, chips 0 . 050000 

Full comment : 0284001 

0103297000 lC Potato, dry (granules/ flakes) 0 . 050000 

Full comment : 0284001 

0103297001 lC Potato, dry (granules/ flakes)-b 0 . 050000 

Full comment : 0284001 

0103298000 lC Potato , flour 0 . 050000 

Full comment : 0284001 

0103298001 lC Potato, flour- babyfood 0 . 050000 

Full comment : 0284001 

0103299000 lC Potato, tuber, w/peel 0 . 050000 

Full comment : 0284001 

0103299001 lC Potato, tuber, w/peel-babyfood 0 . 050000 

Full comment : 0284001 

0103300000 lC Potato, tuber, w/o peel 0 . 050000 

Full comment : 0284001 

0103300001 lC Potato, tuber, w/o peel-babyfood 0 . 050000 

Full comment : 0284001 

0103366000 lCD Sweet potato 0 . 050000 

Full comment : 0284001 

0103366001 lCD Sweet potato- babyfood 0 . 050000 

Full comment : 0284001 

0103371000 lCD Tanier, corm 0 . 050000 

Full comment : 0284001 

0103387000 lCD Turmeric 0 . 050000 

Full comment : 0284001 

0103406000 lCO Yam, true 0 . 050000 

Full comment : 0284001 

0103407000 lCD Yam bean 0 . 050000 

Full comment : 0284001 

0301165000 3A Garlic, bulb 2 . 000000 

0301165001 3A Garlic , bulb-babyfood 2 . 000000 

0301237000 3A Onion, bulb 2 . 000000 

Full comment : 0284001 

0301237001 3A Onion, bulb- babyfood 2 . 000000 

Full comment : 0284001 

0301238000 3A Onion, bulb, dried 2 . 000000 

Full comment : 0284001 

0301238001 3A Onion, bulb, dried- babyfood 2 . 000000 

Page 15 of22 

1 . 000 1 . 000 028400 

1 . 000 1 . 000 028400 

6 . 500 1 . 000 028400 

6 . 500 1 . 000 028400 

6 . 500 1 . 000 028400 

6 . 500 1 . 000 028400 

1 . 000 1 . 000 028400 

1 . 000 1 . 000 028400 

1 . 000 1 . 000 028400 

1 . 000 1 . 000 028400 

1 . 000 1 . 000 028400 

1 . 000 1 . 000 028400 

1 . 000 1 . 000 028400 

1 . 000 1 . 000 028400 

1 . 000 1 . 000 028400 

1 . 000 1 . 000 028400 

1. 000 1. 000 

1.000 1. 000 

1 . 000 1 . 000 028400 

1 . 000 1 . 000 028400 

9 . 000 1 . 000 028400 

9 . 000 1 . 000 028400 
Pyrimethanil Dietary Exposure and Risk Assessment DP# 424861 

Full comment : 02B4001 

030133BOOO 3A Shallot, bulb 2 . 000000 1 . 000 1 . 000 

0302103000 3B Chive , fresh leaves 3 . 000000 1 . 000 1 . 000 

030219BOOO 3B Leek 3 . 000000 1 . 000 1 . 000 

0302239000 3B Onion, green 3. 000000 1 . 000 1 . 000 02B400 

Full comment : 02B4001 

030233B500 3B Shallot, fresh leaves 3 . 000000 1 . 000 1 . 000 

OB01374000 BA Tomatillo 0 . 500000 1 . 000 1 . 000 

OB01375000 BA Tomato 0 . 500000 1 . 000 1 . 000 02B400 

Full comment : 02B4001 

OB01375001 BA Tomato-babyfood 0 . 500000 1 . 000 1 . 000 02B400 

Full comment : 02B4001 

OB01376000 BA Tomato, paste 0 . 500000 5 . 400 1 . 000 02B400 

Full comment : 02B4001 

OB01376001 BA Tomato , paste- babyfood 0 . 500000 5 . 400 1 . 000 02B400 

Full comment : 02B4001 

OB01377000 BA Tomato , puree 0 . 500000 3 . 300 1 . 000 02B400 

Full comment : 02B4001 

OB01377001 BA Tomato , puree-babyfood 0 . 500000 3 . 300 1 . 000 02B400 

Full comment : 02B4001 

OB0137BOOO BA Tomato , dried 0 . 500000 14 . 300 1 . 000 02B400 

Full comment : 02B4001 

OB0137B001 BA Tomato , dried-babyfood 0 . 500000 14 . 300 1.000 02B400 

Full comment : 02B4001 

OB01379000 BA Tomato , juice 0 . 500000 1 . 500 1 . 000 028400 

Full comment : 0284001 

OB013BOOOO BA Tomato , Tree 0 . 500000 1 . 000 1 . 000 

0902135000 98 Cucumber 1 . 500000 1 . 000 1 . 000 

1001106000 lOA Citron 10 . 000000 1 . 000 1 . 000 02B400 

Full comment : 02B4001 

1001107000 lOA Citrus hybrids 10 . 000000 1 . 000 1.000 02B400 

Full comment : 02B4001 

1001108000 lOA Citrus, oil 150 . 000000 1 . 000 1 . 000 02B400 

Full comment : 02B4001 

1001240000 lOA Orange 10 . 000000 1 . 000 1 . 000 02B400 

Full comment : 02B4001 

1001241000 lOA Orange , juice 10 . 000000 0 . 007 1 . 000 02B400 

Full comment : 02B4001 

1001241001 lOA Orange , juice- baby food 10 . 000000 0 . 007 1 . 000 028400 

Full comment : 0284001 

1001242000 lOA Orange , peel 10 . 000000 1 . 000 1 . 000 02B400 

Full comment : 0284001 

1001369000 lOA Tangerine 10 . 000000 1 . 000 1 . 000 02B400 

Full comment : 02B4001 

1001370000 lOA Tangeri ne , j uice 10 . 000000 2 . 300 1 . 000 028400 

Fu ll comment : 02B4001 

1002197000 lOB Kumquat 10 . 000000 1 . 000 1 . 000 02B400 

Full comment : 02B4001 

1002199000 lOB Lemon 10 . 000000 1 . 000 1 . 000 BE7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1002200000 108 Lemon , juice 10 . 000000 2 . 000 1 . 000 BE7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1002200001 lOB Lemon , juice-babyfood 10 . 000000 2 . 000 1 . 000 BE7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1002201000 108 Lemon , peel 10 . 000000 1 . 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1002206000 108 Lime 10 . 000000 1 . 000 1 . 000 028400 

Full comment : 02B4001 

1002207000 lOB Lime , juice 10 . 000000 2 . 000 1 . 000 028400 

Full comment : 02B4001 

1002207001 lOB Lime , juice-babyfood 10 . 000000 2 . 000 1 . 000 02B400 

Full comment : 0284001 

10031BOOOO lOC Grapefruit 10 . 000000 1 . 000 1 . 000 028400 

Full comment : 0284001 

1003181000 lOC Grapefruit , juice 10 . 000000 2 . 100 1 . 000 028400 

Full comment : 0284001 

1003307000 lOC Pummelo 10 . 000000 1 . 000 1 . 000 028400 

Full comment : 0284001 

1100007000 11 Apple , fruit with peel 15 . 000000 1 .000 1 . 000 DP# 34 

Full comment : OPff 347248 

llOOOOBOOO 11 Apple , peeled fruit 15 . 000000 1 . 000 1 . 000 DP# 34 

Page 16of22 
Pyrimethanil Dietary Exposure and Risk Assessment DP# 424861 

Full comment : DP# 347248 

1100008001 11 Apple, peeled fruit· babyfood 15 .000000 1.000 1.000 DPtt 34 

Full comment : DP# 347248 

1100009000 11 Apple , dried 15 . 000000 8 . 000 1 . 000 DP# 34 

Full comment : DP# 347248 

1100009001 11 Apple , dried-babyfood 15 . 000000 8 . 000 1 . 000 DP# 34 

Full comment : DP# 347248 

1100010000 11 Apple , juice 15 . 000000 0 . 350 1 . 000 DP# 34 

Full comment : DP# 347248 

1100010001 11 Apple , juice- babyfood 15 . 000000 0 . 350 1 . 000 DP# 34 

Full comment : DP!I 347248 

1100011000 11 Apple , sauce 15 . 000000 1 . 000 1 . 000 DPll 34 

Full comment : DP!I 347248 

1100011001 11 Apple , sauce-babyfood 15 . 000000 1 . 000 1 . 000 DP# 34 

Full comment : DP# 347248 

1100129000 11 Crabapple 15 . 000000 1 . 000 1 . 000 DP# 34 

E'ull comment : DP# 347248 

1100210000 11 Loquat 15 . 000000 1 . 000 1 . 000 DP# 34 

Full comment : DP# 347248 

1100266000 11 Pear 15 . 000000 1 . 000 1 . 000 DP# 34 

Full comment : DP# 347248 

1100266001 11 Pear-baby food 15 . 000000 1 . 000 1 . 000 DP# 34 

Full comme nt : DP# 347248 

1100267000 11 Pear, dried 15 . 000000 6. 250 1 . 000 DP# 34 

Full comment : DP# 347248 

1100268000 11 Pear, juice 15 . 000000 1 . 000 1 . 000 DP# 34 

Full comment : DP# 347248 

1100268001 11 Pear, juice- babyfood 15 . 000000 1 . 000 1 . 000 DP# 34 

Full comment : DP# 347248 

1100310000 11 Quince 15 . 000000 1 . 000 1 . 000 DP# 34 

Full comment : DP# 347248 

1201090000 12A Cherr y 10 . 000000 1 . 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1201090001 12A Cherry- babyfood 10 . 000000 1 . 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1201091000 12A Cherry, juice 10 . 000000 1 . 500 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1201091001 12A Cherry, juice- babyfood 10 . 000000 1 . 500 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1202012000 128 Apricot 10 . 000000 1 . 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1202012001 128 Apricot-babyfood 10 . 000000 1 . 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1202013000 128 Apricot , dried 10 . 000000 6 . 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1202014000 128 Apricot , j uice 10 . 000000 1 . 000 1 . 000 8E7353 

Fu ll comment : 8E7353 Pr oposed Tolerance 2009 

1202014001 128 Apricot, juice-babyfood 10 . 000000 1 . 000 1 . 000 8E7353 

Full comme nt : 8E7353 Proposed Tolerance 2009 

1202230000 128 Nectarine 10 . 000000 1 . 000 1 . 000 8E7353 

Full comment : 8E7353 Pr oposed Tolerance 2009 

1202260000 128 Peach 10 . 000000 1 . 000 1 . 000 8E7353 

Full comment : 8£7353 Proposed Tolerance 2009 

1202260001 128 Peach-baby food 10 . 000000 1 . 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1202261000 128 Peach, dried 10 . 000000 7 . 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1202261001 128 Peach, dried-babyfood 10 . 000000 7 . 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1202262000 128 Peach, Juice 10 . 000000 1 . 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1202262001 128 Peach, juice-babyfood 10 . 000000 1 . 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tole rance 2009 

1203285000 12C Plum 10 . 000000 1 . 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1203285001 12C Plum-baby food 10 . 000000 1 . 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1203286000 12C Plum, prune , fresh 10 . 000000 1 . 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1203286001 12C Plum, prune , fresh-babyfood 10 . 000000 1 . 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

Page 17 of22 
Pyrimethanil Dietary Exposure and Risk Assessment DP# 424861 

1203287000 12C Plum, prune , dried 10 . 000000 5 . 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1203287001 12C Plum, prune , dried- baby food 10 . 000000 5 . 000 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1203288000 12C Plum, prune , juice 10 . 000000 1 . 400 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1203288001 12C Plum, prune , juice-babyfood 10 . 000000 1 . 400 1 . 000 8E7353 

Full comment : 8E7353 Proposed Tolerance 2009 

1301055000 13A Blackberry 15 . 000000 1 . 000 1 . 000 

1301056000 13A Blackberry, juice 15 . 000000 1 . 000 1 . 000 

1301056001 13A Blackberry, juice-babyfood 15 . 000000 1 . 000 1 . 000 

1301058000 13A Boysenberry 15 . 000000 1 . 000 1 . 000 

1301208000 13A Loganberry 15 . 000000 1 . 000 1 . 000 

1301320000 13A Raspberry 15 . 000000 1 . 000 1 . 000 

1301320001 13A Raspberry-babyfood 15 . 000000 1 . 000 1.000 

1301321000 13A Raspberry , juice 15 . 000000 1 . 000 1 . 000 

1301321001 13A Raspberry , juice- babyfood 15 . 000000 1 . 000 1 . 000 

1302057000 13B Blueberry 8 . 000000 1 .000 1 . 000 

1302057001 13B Blueberry-babyf ood 8 . 000000 1 . 000 1 . 000 

1302136000 13B Currant 8 . 000000 1 . 000 1 . 000 

1302137000 13B Currant , dried 8 . 000000 1 . 000 1 . 000 

1302149000 138 Elderberry 8 . 000000 1 . 000 1 . 000 

1302174000 138 Gooseberry 8 . 000000 1 . 000 1 . 000 

1302191000 13B Huckleberry 8 . 000000 1 . 000 1 . 000 

1304175000 130 Grape 5 . 000000 1 . 000 1 . 000 028400 

Full comment : 0284001 

1304176000 130 Grape , juice 5 . 000000 1 . 200 1 . 000 028400 

Full comment : 0284001 

1304176001 130 Grape , juice-babyfood 5 . 000000 1 . 200 1 . 000 028400 

Full comment : 0284001 

1304 179000 130 Grape , wine and sherry 5 . 000000 1 . 000 1 . 000 028400 

Full comment : 0284001 

1307130000 13G Cranberry 3 . 000000 1 . 000 1 . 000 

1307130001 13G Cranberry-baby food 3 . 000000 1 . 000 1 . 000 

1307131000 13G Cranberry, dried 3 . 000000 1 . 000 1 . 000 

1307132000 13G Cranberry, juice 3 . 000000 1.100 1 . 000 

1307132001 13G Cranberry, juice-baby food 3 . 000000 1 . 100 1 . 000 

1307359000 13G Strawberry 3. 000000 1 . 000 1 . 000 028400 

Full comment : 0284001 

1307359001 13G Strawberry-babyfood 3 . 000000 1 . 000 1 . 000 028400 

Full comment : 0284001 

1307360000 13G Strawberry, juice 3 . 000000 1 . 000 1 . 000 028400 

Full comment : 0284001 

1307360001 13G Strawberry, juice-babyfood 3 . 000000 1 . 000 1 . 000 028400 

Full comment : 0284001 

1400003000 14 Almond 0 . 200000 1 . 000 1 . 000 028400 

Full comment : 0284001 

1400003001 14 Almond-baby food 0 . 200000 1 . 000 1 . 000 028400 

Full comment : 0284001 

1400004000 14 Almond , oil 0 . 200000 1 . 000 1 . 000 028400 

Full comment : 0284001 

1400004001 14 Almond , oil-babyfood 0 . 200000 1 . 000 1 . 000 028400 

Full comment : 0284001 

1400282000 14 Pistachio 0 . 200000 1 . 000 1 . 000 

3100044000 31 Beef, meat 0 . 010000 1 . 000 1 . 000 028400 

Full comment : 0284001 

3100044001 31 Beef, meat-baby food 0 . 010000 1 . 000 1 . 000 028400 

Full comment : 0284001 

3100045000 31 Beef, meat , dried 0 . 010000 1 . 920 1 . 000 028400 

Full comment : 0284001 

3100046000 31 Beef, meat byproducts 0 . 010000 1 . 000 1 . 000 028400 

Full comment : 0284001 

3100046001 31 Beef, meat byproducts-babyfood 0 . 010000 1 . 000 1 . 000 028400 

Full comment : 0284001 

3100047000 31 Beef, fat 0 . 010000 1 . 000 1 . 000 028400 

Full comment : 0284001 

3100047001 31 Beef, fat-babyfood 0 . 010000 1 . 000 1 . 000 028400 

Full comment : 0284001 

3100048000 31 Beef, kidney 2 .500000 1 . 000 1 . 000 DP# 34 

Full comment : OPH 347248 

3100049000 31 Beef, liver 0 . 010000 1 . 000 1 . 000 028400 

Page 18 of22 
Pyrimethanil Dietary Exposure and Risk Assessment DP# 424861 

Full comment : D284001 

3100049001 31 Beef, liver-babyfood 0 . 010000 1 . 000 1 . 000 028400 

Full comment : 0284001 

3200169000 32 Goat , meat 0 . 010000 1 . 000 1 . 000 D28400 

Full comment : D284001 

3200170000 32 Goat , meat byproducts 0 . 010000 1 . 000 1 . 000 D28400 

Full comment : D284001 

3200171000 32 Goat , fat 0 . 010000 1 . 000 1 . 000 D28400 

Full comment : D284001 

3200172000 32 Goat, kidney 2 . 500000 1 . 000 1 . 000 DP!t 34 

Full comment : DPH 347248 

3200173000 32 Goat , liver 0 . 010000 1 . 000 1 . 000 028400 

Full comment : D284001 

3300189000 33 Horse , meat 0 . 010000 1 . 000 1 . 000 D28400 

Full comment : D284001 

3500339000 35 Sheep, meat 0 . 010000 1 . 000 1 . 000 D28400 

Full comment : D284001 

3500339001 35 Sheep, meat- babyfood 0 . 010000 1 . 000 1 . 000 028400 

Full comment : 028 4001 

3500340000 35 Sheep, meat byproducts 0 . 010000 1 . 000 1 . 000 D28 400 

Full comment : 0284001 

3500341000 35 Sheep, fat 0 . 010000 1.000 1 . 000 028 400 

Full comment : 0284001 

3500341001 35 Sheep, fat- babyfood 0 . 010000 1 . 000 1 . 000 D28400 

Full comment : D284001 

3500342000 35 Sheep, kidney 2 . 500000 1 . 000 1 . 000 DP# 34 

Full comment : DP ti 347248 

3500343000 35 Sheep, liver 0 . 010000 1 . 000 1 . 000 D28400 

Full comment : D284001 

3600222000 36 Milk , fat 0 . 050000 1 . 000 1 . 000 DP# 34 

Full comment : DP# 347248 

3600222001 36 Milk , fat-baby food/infant formu 0 . 050000 1 . 000 1 . 000 DPH 34 

Full comment : DP# 347248 

3600223000 36 Milk, nonfat solids 0 . 050000 1.000 1 . 000 DPH 34 

Full comment : DPli 347248 

3600223001 36 Milk, nonfat solids-baby food/in 0 . 050000 1 . 000 1 . 000 DP# 34 

Full comment : DP# 347248 

3600224000 36 Milk , water 0 . 050000 1 . 000 1 . 000 DP# 34 

Full comment : DP# 347248 

3600224001 36 Milk , water- baby food/infant form 0 . 050000 1 . 000 1 . 000 DP# 34 

Full comment : DP# 347248 

3600225001 36 Milk , sugar (lactose) -baby food/ 0 . 050000 1 . 000 1 . 000 DP# 34 

Full comment : DP# 347248 

8601000000 86A Water, direct, all sources 0 . 027900 1 . 000 1 . 000 

8602000000 86B Water, indirect, all sources 0 . 027900 1 . 000 1 . 000 

9500023000 0 Banana 0 . 100000 1 . 000 1.000 

9500023001 0 Banana-babyfood 0 . 100000 1.000 1 . 000 

9500024000 0 Banana , dried 0 . 100000 3 . 900 1.000 

9500024001 0 Banana , dried- baby food 0 . 100000 3 . 900 1.000 

9500177000 0 Grape , leaves 5 . 000000 1 . 000 1 . 000 D28400 

Full comment : D284001 

9500178000 0 Grape , raisin 8 . 000000 1 . 000 1 . 000 D28400 

Full comment : D284001 

9500283000 0 Plantain 0 . 100000 1 . 000 1 . 000 

9500284000 0 Plantain, dried 0 . 100000 3 . 900 1 . 000 

9500289000 0 Pomegranate 5 . 000000 1 . 000 1 . 000 

Page 19 of22 
Pyrimethanil Dietary Exposure and Risk Assessment DP# 42486 1 

Attachment 4: DEEM-FCID Chronic Exposure and Risk Estimates - Food plus Water 

us EPA Ver . 3 . 16, 03- 08 - d 

DEEM- FCID Chronic ana lysis for PYRIMETHANIL NHANES 2003-2008 2-day 

Residue file name : C : \Users\gkramer\Documents\Gk\#Pyrimethanil\Pyrimethanil chronic . R08 

Adjustment factor lt2 used . 

Analysis Date 05- 28- 2015/11 : 03 : 22 Residue file dated : 05-28-2015/09 : 57 : 00 

Reference dose (RfD, Chronic) = . 17 mg/kg bw/day 

COMMENT 1 : FQPA SF lX for all endpoints; cPAD for all popu la tions is 0 . 17 mg/kg/day 

Population 

Subgroup 

Total us Population 

Hispanic 

Non-Hisp-White 

Non-Hisp-Black 

Non-Hisp-Other 

Nursing Infants 

Non-Nursing Infants 

Female 13+ PREG 

Children 1- 6 

Children 7-12 

Male 13-19 

Female 13-19/NP 

Male 20+ 

Female 20+/NP 

Seniors 55+ 

All Infants 

Female 13-50 

Children 1-2 

Children 3 - 5 

Children 6-12 

Youth 13-19 

Adults 20-49 

Adults 50-99 

Female 13-49 

Total exposure by population subgroup 

Tota l Exposure 

mg/kg 

body wt/day 

0 . 024977 

0 . 031428 

0 . 023423 

0 . 024807 

0 . 029368 

0 . 059140 

0 . 104490 

0 . 021041 

0 . 098700 

0 . 033432 

0 . 014965 

0 . 017081 

0 . 014481 

0 . 016288 

0 . 017384 

0 . 090488 

0 . 015559 

0 . 136305 

0 . 082594 

0 . 038145 

0 . 016025 

0 . 014440 

0 . 017030 

0 . 015479 

Page 20 of22 

Percent of 

Rfd 

14 . 7% 

18 . 5% 

13 . 8 % 

14 . 6% 

17 . 3 % 

34 . 8% 

61.5% 

12 . 4% 

58 . 1% 

19 . 7% 

8 . 8 % 

10 . 0% 

8 . 5% 

9 . 6% 

10 . 2% 

53 . 2% 

9 . 2% 

80 . 2% 

48 . 6% 

22 . 4% 

9 . 4% 

8 . 5 % 

10 . 0% 

9 . 1% 
Pyrimethanil Dietary Exposure and Risk Assessment DP# 424861 

Attachment 5: DEEM-FCID Acute Exposure and Risk Estimates - Food Only 

US EPA 

DEEM-FCID ACUTE Analysis for PYRIMETHANIL 

Residue file : Pyrimethanilacute_ Food only . ROS 

Analysis Date : 05- 28 - 2015/11 : 09 : 13 Residue file 

Ver . 3 . 18 , 03 - 08 - d 

NHANES 2003- 2008 2-Day 

Adjustment factor #2 used . 

dated : 05-28- 2015/09 : 56 : 27 

NOEL (Acute ) = 100 . 000000 mg/kg body- wt/day 

RAC/FF intake summed over 24 hours 

Run Comment : " FQPA SF lX for all endpoints; cPAD for all populations is 0 . 17 m 

g/kg/day" 

Summary calculations--per capita : 

95th Percentile---- 99th Percentile---- ---99 . 9th Percentile----

Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE 

---------- ------- -------- ---------- ---- --- -------- ---------- ------- -------- Total us Population : 

0 . 100979 10 . 10 990 0 . 238699 23 . 87 418 0 . 510901 51. 09 195 

All Infants: 

0 . 366002 36 . 60 273 0 . 551032 55 . 10 181 0 . 717833 71 . 78 139 

Children 1-2 : 

0 . 392227 39 . 22 254 0 . 621139 62 . 11 160 0 . 978217 97 . 82 102 

Children 3-5 : 

0 . 251471 25 . 15 397 0 . 365350 36 . 54 273 0 . 552961 55 . 30 180 

Children 6-12 : 

0 . 134614 13 . 46 742 0 . 231633 23 . 16 431 0 . 376438 37 . 64 265 

Youth 13-19 : 

0 . 061527 6 . 15 1625 0 . 117545 11. 75 850 0 . 260147 26 . 01 384 

Adults 20-49 : 

0 . 056690 5 . 67 1763 0 . 099946 9 . 99 1000 0 . 191079 19 . 11 523 

Adults 50-99 : 

0 . 059286 5 . 93 1686 0 . 097410 9 . 74 1026 0 . 176266 17 . 63 567 

Female 13-49 : 

0 . 059514 5 . 95 1680 0 . 103518 10 . 35 966 0 . 231358 23 . 14 432 

Page 21 of22 
Pyrimethanil Dietary Exposure and Risk Assessment DP# 424861 

Attachment 6: DEEM-FCID Chronic Exposure and Risk Estimates - Food Only 

US EPA Ver . 3 . 16, 03-08-d 

DEEM-FCID Chronic analysis for PYRIMETHANIL NHANES 2003-2008 2- day 

Residue file name : C: \Users\gkramer\Documents\Gk\#Pyrimethanil\Pyri me t hanilchroni c_Food 

only . ROB 

Adjustment factor ~2 used . 

Analysi s Date 05- 28- 2015/11 : 04 : 42 Residue file dated : 05-28-2015/09 : 57 : 39 

Reference dose (RfD, Chronic) = . 17 mg/kg bw/day 

COMMENT 1 : FQPA SF lX for all endpoints; cPAD for a l l populati ons is 0 . 17 mg/kg/day 

Population 

Subgroup 

Total US Population 

Hispanic 

Non-Hisp-White 

Non- Hisp- Black 

Non- Hisp-Other 

Nursi ng Inf ants 

Non- Nursi ng Infants 

Female 13+ PREG 

Children 1-6 

Children 7- 12 

Male 13- 19 

Female 13- 19/NP 

Male 20+ 

Female 20+/NP 

Seniors 55+ 

All Infants 

Female 13-50 

Children 1- 2 

Children 3-5 

Children 6- 12 

Youth 13- 19 

Adul ts 20-49 

Adul ts 50-99 

Female 13-49 

Total exposure by popul ation subgroup 

Total Exposure 

mg/kg 

body wt/day 

0 . 024393 

0 . 030871 

0 . 022822 

0 . 024325 

0 . 028695 

0 . 058611 

0 . 102546 

0 . 020491 

0 . 097952 

0 . 032945 

0 . 014564 

0 . 016631 

0 . 013937 

0 . 015675 

0 . 016819 

0 . 088982 

0 . 014978 

0 . 135463 

0 . 081884 

0 . 037633 

0 . 015599 

0 . 013857 

0 . 016454 

0 . 014899 

Page 22 of22 

Percent o f 

Rf d 

14 . 3% 

18 . 2% 

13 . 4% 

14 . 3% 

16 . 9% 

34 . 5% 

60 . 3% 

12 . 1% 

57 . 6% 

19 . 4% 

8 . 6% 

9 . 8% 

8 . 2% 

9 . 2% 

9 . 9% 

52 . 3% 

8 . 8% 

79 . 7% 

48 . 2% 

22 . 1% 

9 . 2% 

8 . 2% 

9 . 7% 

8 . 8%