Offer Letter



 Exhibit 10.10 
 Lewicki Offer Ltr 5-27-04 
 Cancer Stem Cell Genomics, Inc. 

May 27, 2004 
 John A. Lewicki 

[Address] 
 Dear John, 

As we discussed, I am delighted to make you this offer to join Cancer Stem Cell Genomics, Inc. (the “Company”), as Senior Vice President of
Research and Development, reporting to the Chief Executive Officer (CEO). The terms and conditions of our offer are as follows: 
  

	•	 	 Start Date. Your employment with the Company will commence on 15 July, 2004 



 

	•	 	 Salary. Your annual salary will be $210,000, less applicable withholding. This salary will be paid in accordance with our payroll procedures.
Your salary shall be subject to review and adjustment, based on your performance, by the CEO and the Company’s Board of Directors (the “Board”) an at least an annual basis. 



 

	•	 	 Bonus. Initially there will be no bonus opportunity, but if a management bonus program is initiated in the future you will be eligible to
participate. 


  

	•	 	 Stock Option. Subject to the approval of the Board, you will be granted an option to purchase 350,000 shares of common stock of Company (the
“Option”). At your request, the Option shall be an incentive stock option to the maximum extent permitted under the applicable federal income tax rules and shall have an exercise price equal to the fair market value of Company’s stock
as of the date the Option is granted. Subject to your remaining continuously employed by Company as of each such date the Option shall vest and become exercisable with respect to 20% of the shares subject to the Option on the first anniversary of
your commencement of employment, and shall become vested in equal monthly installments thereafter, such that the Option is vested and exercisable with respect to 100% of the shares subject to the Option on the fifth anniversary of the Option’s
date of grant. The specific terms of the Option grant will be set forth in a written Stock Option Agreement between you and the Company which will be executed after your employment commences with Company. You will also be eligible for future stock
option grants based on your performance and as part of general company practices. 


  

	•	 	 Change of Control If your employment is terminated without Cause or Constructively Terminated (as defined below) in connection with, or within
twelve (12) months after, a Change of Control of the Company, regular vesting of your Option or shares shall cease upon your termination and you will be eligible to receive accelerated vesting of fifty percent (50%) of your then unvested
Options. 



  
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	•	 	 For the purpose of this letter, “Cause” means: (i) an act of dishonesty made by you in connection with your responsibilities as an
employee that causes serious reputational harm to the Company; (ii) your conviction of, or plea of nolo contendere to, a felony; (iii) your gross negligence or willful misconduct in the performance of your duties; (iv) your inability
to perform the essential functions of your job with or without a reasonable accommodation; or (v) your failure or refusal to carry out any lawful direction of the Board or your habitual neglect of your duties as an officer of the Company, which
failure, refusal or neglect, as applicable, if capable of cure, shall continue after receipt of written notice from the Board (provided, however, that you shall have fifteen (15) days after receipt of written notice to cure any such failure,
refusal or neglect), in each case as determined in good faith by the Board. 


 For the purpose of this letter,
“Change of Control” means: (i) any “person” (as such term is used in Sections 13(d) and 14(d) of the Securities Exchange Act of 1934, as amended) is or becomes the “beneficial owner’’ (as defined in Rule 13d-3
under said Act), directly or indirectly, of securities of the Company representing 50% or more of the total voting power represented by the Company’s then outstanding voting securities or (ii) the date of the consummation of a merger or
consolidation of the Company with any other corporation that has been approved by the stockholders of the Company, other than (a) a merger or consolidation which would result in the voting securities of the Company outstanding immediately prior
thereto continuing to represent (either by remaining outstanding or by being converted into voting securities of the surviving entity) more than 50% of the total voting power represented by the voting securities of the Company or such surviving
entity outstanding immediately after such merger or consolidation, (b) the stockholders of the Company approve a plan of complete liquidation of the Company, or (c) any transaction in which the directors comprising the Board of the Company
immediately prior to the transaction represent a majority of the Board of the Company, or other surviving entity, immediately after the transaction. Notwithstanding the foregoing, a transaction shall not constitute a Change of Control if:
(i) its sole purpose is to change the state of the Company’s incorporation; (ii) its sole purpose is to create a holding company that will be owned in substantially the same proportions by the persons who held the Company’s
securities immediately before such transaction; (iii) it constitutes the Initial Public Offering, or (iv) it is a transaction effected primarily for the purpose of financing the Company with cash (as determined by the Board acting in good
faith and without regard to whether such transaction is effectuated by a merger, equity financing or otherwise). 
 For the
purpose of this letter, “Constructive Termination” means (i) a material reduction in your responsibilities, duties or base pay without your agreement or (ii) relocation of your workplace more than 35 miles from your prior
workplace without your agreement. 
  

	•	 	 At Will Employment. If you accept this offer, your employment with the Company will be at will. 



 

	•	 	 Company Rules. As an employee of the Company, you will be expected to abide by company rules and regulations. As a condition of employment, you
will be required to sign and comply with a confidential information and invention assignment agreement 



  
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which, among other things, prohibits unauthorized use or disclosure of Company’s proprietary information. 



 

	•	 	 No Bar to Employment. You agree that you are not party to any contract or agreement that would preclude you from accepting this offer or
performing services as an employee for Company. As required by law, this offer is subject to satisfactory proof of your right to work in the United States. 



 

	•	 	 Final Agreement. The employment terms in this letter supersede any other agreements or promises made to you by anyone, whether oral or written,
and comprise the final, complete and exclusive agreement between you and the Company. 


 We are very enthusiastic that you
have agreed to join our team and we look forward to working with you to make CSCG a success. Please sign and return one copy of this letter to confirm your understanding and agreement with the above terms. 

Sincerely, 
  

	
	 /s/ James N. Woody

	 James N. Woody MD, PhD,
 Chief
Executive Officer (Upon Closing)
 Cancer Stem Cell Genomics, Inc.


  

							
	Agreed and accepted:	 		 		 	
				
	 /s/ John A. Lewicki
	 		 	 8-27-04
	 	
	John A. Lewicki	 		 	Date	 	


  
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