Aldicarb Die1ary Exposure and Risk Assessment DP Number: 0430197 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

OFFICE OF CHEMICAL SAFETY AND 

POLLUTION PREVENTION 

MEMORANDUM 

Date: 03/28/20 16 

SUBJECT: Aldicarb. Acute Aggregate Dietary (Food and Drinking Water) Exposure and 

Risk Assessments for Registration Review Risk Assessment. 

PC Code: 09830 I 

Decision No.: - 1498310 

Petition No.: NA 

DP Barcode: D430197 

Registration No.: 87895-1 

Regulatory Action: Registration Review 

Risk Assessment Type: Dietary Case No.: 0 140 

TXR No.: NA CAS No.: 116-06-3 

MRID No.: NA 40 CFR: § 180.269 

FROM: 

THROUGH: 

Ideliz Negr6n-Encarnaci6n, Ph.D., Chemist ~Lc....c...----­ Risk Assessment Branch V (RAB V) '"7 

Health Effects Division (HED; 7509P) 

Danette Drew, Chemist (RABY; HED) ./ i T ;/ J j 

Michael S. Metzger, Branch Chief(RAJ?V; HED ~tl{/' · 

Steve Nako, Ph.D., Statistician .f./1.v111- h!t 7,,J-€7 

Chemistry and Exposure Branch (HE ) · 

Thurston Mo11on and , Chemist 

e · 

Kristin Rickard, Biologist \L! 

Dietary Exposure Science Advisory Council (DESAC; HED) 

TO: Susan Bartow, Chemical Review Manager 

Tom Myers, Team Leader 

Pesticide Re-evaluation Division (PRD; 7508P) 

Executive Summary 

Acute aggregate dietary (food only, food and drinking water, and drinking water only) exposure 

and risk assessments were conducted using the Dietary Exposure Evaluation Model software 

with the Food Commodity Intake Database (DEEM-FCID) Version 3.1 6. This software uses 

2003-2008 food consumption data from the U.S. Department of Agriculture's (USDA 's) 

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Aldicarb Dietary Exposure and Risk Assessment DP Number: 0430197 

National Health and Nutrition Examination Survey, What We Eat in America, 

(NHANES/WWEIA). The analyses were conducted in support of the registration review risk 

draft risk assessment (DRA). This memorandum was reviewed by two peer reviewers of the 

DESAC (and the entire DESAC on 1211012015), per DESAC SOP 2012.1. 

Acute dietary exposure assessments incorporated USDA Pesticide Data Program (POP) 

monitoring data for aldicarb and its metabolites aldicarb sulfoxide and aldicarb sulfone, 

anticipated residues, field trial data, tolerances, empirical processing factors, default DEEM 

processing factors, and percent crop treated (CT) estimates. Aldicarb metabolites were assumed 

to have similar toxicity to the parent. The Environmental Fate and Effects Division (EFED) 

provided daily time series outputs for the scenario that provided the highest and lowest estimated 

drinking water concentrations (EDWCs). The highest EOWC was for surface water in Minnesota 

(MN sugar beets PRZM scenario) after application of the rate used for sugar beets (named 

thereafter MN Sugar Beets). The scenario that provided the lowest EDWC was surface water in 

California (CA cqtton PRZM scenario) after application of the rate used for cotton (named 

thereafter CA Cotton). 

Acute assessments were conducted for food only, drinking water only, and food and drinking 

water. Although the 2010 mitigation agreement indicated that tolerances for pecan, sorghum, 

sugarcane, citrus. and potato were going to be revoked these commodities still have tolerances 

for aldicarb in the 40 CFR. Therefore, these commodities were considered in the dietary 

assessment assuming that residues of aldicarb may be present in imported commodities. As 

such, these commodities were included in the dietary assessment considering the percent of 

imports for those for which data was available and assuming that I 00% of the imported crop is 

treated. Coffee was included in the 2010 dietary assessment in support of use on the imported 

commodity. Commodities with registered uses in the U.S.A. were included with their 

corresponding %CT. Sugar beet and sugarcane were excluded from the assessments, since 

aldicarb residues would not be expected in the processed commodities as consumed. 

This assessment incorporated an estimated half-life for red blood cell (RBC) cholinesterase 

(ChE) inhibition of two hours which is based on data of aldicarb from rats and human subjects. 

HED also refined the acute dietary risk from food and drinking waler by incorporating the time 

and amounts consumed for each eating occasion from the USDA NHANES/WWEIA food 

diaries to estimate exposures and risks on each eating occasion throughout the day and factoring 

in the ChEI half-life related to aldicarb exposure. Refer to C. Olinger memo (0 299883, 

08/ 16/2010) for additional information on the eating occasion analysis. 

A preliminary screening showed that the acute dietary exposure estimates from food alone was 

above HED's level of concern (i.e. >100 % of the aPAD) at the 99.9111 percentile of exposure. 

The commodity with highest contribution to the risk was potato tubers which do not have 

domestic uses currently registered for aldicarb. PDP data for potato (2006-2009) were modified 

to e liminate contribution from domestic samples. An acute dietary assessment using only detects 

from samples of imported potatoes results in risks below the level of concern (i.e. <100 % of the 

a PAD) at the 99.9111 percentile of exposure. Aldicarb food only dietary exposure estimate is 65% 

of the aPAD for children 1-2 years old, the most highl y exposed population subgroup, and 25% 

of the aPAD for the general population. However, the commodity specific analysis results in 

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Aldicarb Dietary Exposure and Risk Assessment DP Number: D430197

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exposure estimates above 100% of the aPAD following consumption of an estimated single 

serving of sweet potato or potatoes. 

Exposures are above the level of concern (LOC) for drinking water only. Dietary exposure 

estimates ranged from 1,400% to 2,900%, and 150% to 340% of the aPAD at the 99.9th

percentile of exposure for the general population and most population subgroups using the 

scenarios that resulted in the highest EDWC (MN sugar beets) and lowest EDWC (CA Cotton), 

respectively. Similarly, for food and drinking water, the dietary exposure is above HED’s LOC 

using drinking water scenarios that provided the highest EDWC (MN sugar beets).

A chronic assessment was not conducted because the toxicity database for aldicarb indicates that 

cholinesterase inhibition (ChEI) is the most sensitive effect found, the magnitude of ChEI does 

not increase with continued exposure, and that ChEI is generally reversible within 24 hours at the 

levels relevant to the dietary risk assessment. The longer-term exposures could be considered as 

a series of acute exposures, with regard to ChEI. All other effects noted in the sub-chronic and 

chronic toxicity studies were observed at higher doses. Aldicarb is classified as not likely to be 

carcinogenic to humans; therefore a cancer dietary assessment was not conducted. 

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose that HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population-adjusted dose (PAD). The PAD is equivalent to the 

point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety 

factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in 

more detail are available on the EPA/pesticides web site: “Available Information on Assessing 

Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, web link: 

http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 (20-AUG1999).

The most recent dietary risk assessment for aldicarb was conducted by C. Olinger (08/16/2010, 

D299883).

II. Residue Information

Residues of Concern

The residues of concern for tolerance enforcement and risk assessment are the combined residues 

of aldicarb and its two cholinesterase-inhibiting metabolites aldicarb sulfoxide [2-methyl-2-

(methylsulfinyl)propionaldehyde O-(methyl carbamoyl) oxime] and aldicarb sulfone [2-methyl2-(methylsulfonyl)propionaldehyde O-(methyl carbamoyl) oxime]. In field trials, parent aldicarb 

is typically at or just above the limit of detection (LOD); however, residues of aldicarb sulfoxide 
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and/or aldicarb sulfone are detected more often and at higher levels than that of aldicarb. 

Aldicarb sulfoxide residues are found more frequently than the sulfone, and tend to be higher 

than sulfone residues when both are present. In monitoring data, parent aldicarb is rarely 

detected. Aldicarb sulfoxide is considered to be as potent as the parent in terms of toxicity, 

while the sulfone is less potent. For risk assessment, the metabolites are assumed to have toxicity 

equivalent to parent compound aldicarb. 

Tolerances

Tolerances are established in the 40 CFR § 180.269 for the use of aldicarb on bean, sugar beet, 

coffee, cotton, grapefruit, lemon, lime, orange, peanut, pecan, potato, sorghum, soybean, 

sugarcane and sweet potato. These tolerances are based on measurement of combined residues 

of aldicarb and its cholinesterase-inhibiting metabolites aldicarb sulfoxide [2-methyl-2-

(methylsulfinyl)propionaldehyde O-(methyl carbamoyl) oxime] and aldicarb sulfone [2-methyl2-(methylsulfonyl)propionaldehyde O-(methyl carbamoyl) oxime] and range from 0.02 to 1 ppm. 

The tolerances for dry bean, sugar beet, cotton, peanut, soybean and sweet potato are based on 

domestic uses of aldicarb. Coffee was included in the 2010 dietary assessment in support of use 

on the imported commodity. Although tolerances for potato, citrus, coffee, pecan, sorghum and 

sugar cane are established in the CFR, there are no registered uses in the U.S.A. As tolerances 

for these commodities are in the CFR at this time, these commodities were considered in the 

dietary assessment assuming that residues of aldicarb may be present in imported commodities. 

Although livestock feedstuffs are associated with uses of aldicarb, tolerances are not established 

for livestock commodities because transfer of residues to livestock commodities is not expected 

(i.e., a 40 CFR §180.6(a)(3) situation applies) (W. Donovan, D425180, In Progress). 

Anticipated Residues

USDA PDP monitoring data for potato, sweet potato, and orange (translated to other citrus 

commodities) were incorporated in the dietary assessment. The PDP was specifically designed 

for risk assessment; analysts prepare samples in a manner similar to typical consumer practices, 

such as washing, coring, and peeling. In years 2006 to 2012, USDA PDP analyzed several 

commodities for residues of aldicarb and its metabolites separately. PDP monitoring data were 

used for residues of aldicarb and its metabolites in/on potato, sweet potato, and citrus (orange, 

lemon, lime and grapefruit). Field trial data provided in the previous dietary assessment (C. 

Olinger, D299883, 08/16/2010) were used for soybean, dry beans, pecan, cottonseed, coffee and 

peanut. Tolerance-level residue was used for sorghum. Sugar beet and sugarcane were excluded 

from the assessments, since aldicarb residues would not be expected in the processed 

commodities as consumed. Attachment A.1.2 and A.1.3 summarizes the residue inputs 

(anticipated residues, processing factors, PCT, etc.) and all of the residue distribution files 

(RDFs), respectively, used for the acute assessment. 

Residues of parent aldicarb, aldicarb sulfone, and aldicarb sulfoxide were combined using a 

Statistical Analysis System (SAS) program that matches residues from the same samples using 

the PDP sample IDs. The SAS program directly created the RDFs for use in the acute analysis. 

In some cases, residues of either aldicarb or its metabolites may have not been detected or the 

samples may not have been analyzed for all residues. The set of rules outlined in Table 1 were 
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used to combine the residues for each sample. The total residue was calculated as aldicarb using 

the following formula, which accounts for the difference in molecular weights of the parent and 

two metabolites:

Total residue (as aldicarb) = aldicarb + (aldicarb sulfone x 0.86) + (aldicarb sulfoxide x 0.92)

In order to incorporate non-detectable residues into the exposure assessment, HED used the 

current policy [refer to ChemSAC memo dated 5/19/98 and HED SOP 99.6] of assigning residue 

values of 1⁄2 LOD to these samples. If the residues were determined as the sulfone, then the 1⁄2 

LOD for the total residue determined as the sulfone was used in the analysis. When the parent 

and metabolites were determined individually, using a 1⁄2 LOD of 0.005 ppm (i.e., LOD = 0.01 

ppm) for aldicarb and each of its metabolites, for example, the combined 1⁄2 LOD is as follows:

Total 1⁄2 LOD residue (ppm) = 0.005 + (0.005 x 0.86) + (0.005 x 0.92) = 0.0139 ppm

In the case of field trial data, which is reported on an aldicarb sulfone basis, the conversion to the 

aldicarb basis is done using the following formula, which accounts for the differences in 

molecular weights:

Aldicarb residues = aldicarb sulfone residues (ppm) x 0.86

Table 1. Method for Combining Residues of Aldicarb and it Sulfone and Sulfoxide Metabolites

from the Same PDP Sample.

Aldicarb Metabolite Data Treatment1,2

detect detect Aldicarb detect + Metabolite detect

detect non-detect Aldicarb detect + 1⁄2 LOD for Metabolite for that sample

non-detect detect 1⁄2 LOD for Aldicarb for that sample + Metabolite detect

non-detect non-detect Highest 1⁄2 LOD for Aldicarb + 1⁄2 LOD for Metabolite

1 The highest limit of detection (LOD) for aldicarb and its metabolites was used to estimate the LOD to be included 

in the RDF file or used in point estimate calculations. When aldicarb or its metabolites were not detected, the 

1⁄2LOD of that sample was used and added to the concentration of the analyte that was detected. 

Processing Factors

Processing factors (PFs) for aldicarb in cooked potato food forms (0.62 for fried; 0.5 for boiled), 

dry beans (0.05 for baked, boiled, fried, canned:cooked, canned:boiled, cooked:no food form 

specified), soybean oil (0.3), peanut oil (0.18), and cottonseed oil (0.1), sugarcane, and sugar 

beet have been generated in processing/cooking studies submitted in support of reregistration. 

The studies were considered to be acceptable and appropriate for use in risk assessment and 

tolerance reassessment. The processing/cooking studies indicate a general reduction of residues; 

since residues are systemic, the reduction in residues is not related to removal of certain inedible 

commodity fractions, e.g., peel. Aldicarb processing factors to specific food forms in DEEM is 

described in Table 2. Moreover, DEEM default processing factors of 6.5 for dry potato and 1 for 

the remaining processed commodities were used. Processing factors for citrus juice were not 

needed as PDP data for orange juice was available.
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Table 2. Summary of Aldicarb Processing Factors (PFs) Used in the Dietary Exposure Analyses

Commodity/Processed Food Form PF1 Application of PF to Relevant Food Forms in 

DEEM

Potato, dry 6.5 Potato, dry; Potato, flour

Potatoes/fried 0.62 Potato and Sweet potato:Fried

Potatoes/boiled, cooked 0.5 Potato and Sweet potato - boiled, canned:cooked, 

canned:boiled

Beans, dry 0.05 Baked, boiled, fried, canned:cooked; 

canned:boiled; cooked:NFS

Peanut/oil 0.18 Peanut/Oil

Soybean/oil 0.3 Soybean/Oil

Cottonseed/oil 0.1 Cottonseed/Oil

Sugarcane/sugar beet NA NA

1Processing factors were entered into the DEEM software as Adjustment Factor 1. 

Residues in Fish

The USDA PDP monitored pesticide residues in catfish in 2008, 2009, and 2010. Over this 3-

year period, PDP analyzed 1479 samples of catfish for residues of aldicarb and aldicarb sulfone,

and 552 samples for residues of aldicarb sulfoxide. None of the samples contained detectable 

residues. Moreover, PDP monitored pesticide residues in salmon in 2013. Over this 1-year 

period, PDP analyzed 88 and 29 samples of salmon for residues of aldicarb sulfone and aldicarb 

sulfoxide, respectively. None of the samples contained detectable residues. As a result, residues 

in fish were not included in the assessment.

III. Percent Crop Treated Information

The Biological Economic Analysis Division (BEAD) provided percent of crop treated estimates 

for the years 2004 to 2012. The following maximum percent crop treated estimates (Updated 

Screening Level Usage Analysis Report for Aldicarb, PC Code 098301; 12/18/2014) were used 

in the acute dietary risk assessment for the following crops that are currently registered for 

aldicarb: cotton: 35%; dry beans: 2.5%; peanuts: 45%; soybeans: 2.5%; and sugar beets: 10%. 

100% of crop treated was assumed for sweet potato. Percent of crop treated estimates were 

provided for grapefruit, oranges, lemon, pecans, potato, sorghum, and sugarcane; however, these 

were not used as these crops do not have uses registered in the U.S.A. BEAD provided 

information on the percent of imported commodities for which data was available from 2009-

2013 (e-mail from Donald Atwood; 11/25/2015). The percent of imports were included for the 

following crops: grapefruit: 2%; lemons: 10%; orange: 8%; pecans: 58%; fresh potato: 8%; 

frozen potato: 21%; and 100% was assumed for limes and coffee. 

IV. Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by the EFED in 

the following memorandum: “Aldicarb: Drinking Water Exposure Assessment for Preliminary 

Risk Assessment” (D427697, Edmund Wong, 06/17/2015) and incorporated directly into this 

dietary assessment. Water residues were incorporated in the DEEM-FCID into the food 

categories “water, direct, all sources” and “water, indirect, all sources.” 
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Tier II surface water EDWCs were estimated with the Surface Water Concentration Calculator 

(SWCC). The Pesticide Root Zone Model-Groundwater (PRZM-GW) was used to estimate 

groundwater EDWCs at a pH of 6. TTR degradation varies across pH; therefore, slight acidic

conditions yielded the highest concentration of aldicarb TTR in groundwater. Available 

monitoring data were also evaluated, however, the monitoring studies were non-targeted. Thus, 

these data are not expected to provide an upper bound estimate of the potential exposure to 

aldicarb TTR and it is recommended that the Health Effects Division adopt the EDWC generated 

from the modeling in this assessment. Surface water and groundwater monitoring data indicated 

that aldicarb and its degradates were monitored since February 1986 to December 2014. Based 

on the analysis of the data, even with the mitigation implemented in 2009, there is no discerning 

trend of decline in concentrations in groundwater.

The groundwater EDWCs are less than those for surface water; therefore, it is recommended that 

the EDWCs for surface water be used in dietary assessments conducted by the Health Effects 

Division. The highest one-in-ten year peak, annual mean, and 30-year mean EDWCs (187, 16, 

and 5.3 μg/L, respectively) are based on the labeled use of aldicarb on sugar beets at 4.05 lbs 

a.i./acre per year (MN Sugar Beets). Please note that the application rates for modeling inputs on 

SWCC and PRZM-GW are different due to application instructions on the label. Application rate 

for PRZM-GW was based on the highest application rate that is allowed for labeled use in sugar 

beets but the granules have to be covered with soil or drilled to a specified soil depth. 

Meanwhile, the application rate used for SWCC modeling was the highest rate for sugar beets 

that can be applied without soil cover, which significantly increases the risks of surface water 

exposure. The scenario that provided the lowest EDWC was surface water in California (CA 

cotton PRZM scenario) after application of the rate used for cotton (CA Cotton). Results are 

summarized in Table 3. 

Table 3. Screening-Level TTR EDWCs for Proposed Uses of Aldicarb A

Source (Model) Use Site

(Max. Annual App. Rate)

1-in-10-year 

30-Year Mean

Peak (μg/L) Annual Mean

(μg/L)

Surface water 

(SWCC)

Sugar beets (4.05 lbs a.i./A)B

187 16 5.3

Cotton (1.05 lbs ai/A at 

Planting; 2.1 lbs ai/A

Side Dress)C

23.1 1.75 0.45

Peak Post-Breakthrough Average

Ground water 

(PRZM-GW) (pH 6) Sugar beets (4.95 lbs a.i./A)B 93.2 40

A Maximum values in bold.

B Application rates are different for both surface and ground water modeling because application instructions on the label 

specified that the 4.95 lbs a.i./A rate is covered with soil, thus minimizing surface runoff exposure, while 4.05 lbs a.i./A is the 

highest application rate that can be applied over irrigation furrow without soil cover, which increases potential surface water 

exposure.

C Use site that resulted in the lowest EDWC for aldicarb. 
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The entire 30-year distribution of estimated daily concentrations in surface water obtained for the 

MN Sugar beet and CA Cotton scenarios was incorporated into DEEM-FCID and used in the 

acute probabilistic analyses. The drinking water models and their descriptions are available at 

the EPA internet site: http://www2.epa.gov/pesticide-science-and-assessing-pesticiderisks/about-water-exposure-models-used-pesticide.

V. DEEM-FCID Program and Consumption Information

Aldicarb acute dietary exposure assessments were conducted using the DEEM-FCID, Version 

3.16, which incorporates 2003-2008 consumption data from USDA’s NHANES/WWEIA. The 

data are based on the reported consumption of more than 20,000 individuals over two nonconsecutive survey days. Foods “as consumed” (e.g., apple pie) are linked to EPA-defined food 

commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; 

fresh or N/S, baked) using publicly available recipe translation files developed jointly by 

USDA/ARS and EPA. For acute exposure assessment, consumption data are retained as 

individual consumption events. Based on analysis of the 2003-2008 WWEIA consumption data, 

which took into account dietary patterns and survey respondents, HED concluded that it is most 

appropriate to report risk for the following population subgroups: the general U.S. population, all 

infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, 

females 13-49, and adults 50-99 years old.

For an acute exposure assessment, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or “matched” in multiple random pairings with residue values 

and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating 

relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 

commodities as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for analyses performed at all levels of refinement. However, for 

deterministic assessments, any significant differences in user vs. per capita exposure and risk are 

specifically identified and noted in the risk assessment.

The acute adverse effect of red blood cell cholinesterase inhibition tends to reverse itself within 2 

hours following exposure to aldicarb. Since the food diaries used by DEEM-FCID (Version 

3.16) Model are based on total daily intake, the estimated risks produced by this software are 

overestimates, to the extent that foods and drinking water are consumed throughout the day, 

rather than during only one event. To provide a better approximation of the potential exposure 

leading to peak RBC ChE inhibition, potential exposure from food and/or water to aldicarb was 

computed incrementally throughout the day. This computation was made by incorporating 

information on the time of day and amounts consumed during each occasion from the USDA 

NHANES/WWEIA food diaries. The potential for accumulation of toxicity was accounted for 

by computing the degree to which exposures could be discounted between exposure occasions, 

assuming a two-hour half-life. Further discussion of the methodology used to compute the 
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exposure based on the eating and drinking occasions may be found in a 2006 memo by S. Nako 

(D299889, 11/1/2006).

VI. Toxicological Information

The Agency evaluated the toxicity profile for aldicarb and considered the human acute oral study 

to be appropriate for assessment of the acute dietary exposure and risks, refer to Aldicarb Human 

Health Risk Assessment for the evaluation of EPA’s Human Studies Review Board (D424564, In 

Progress). A chronic assessment was not conducted because the toxicity database for aldicarb 

indicates that cholinesterase inhibition is the most sensitive effect found, the magnitude of 

cholinesterase inhibition does not increase with continued exposure, and that cholinesterase 

inhibition is generally reversible within 24 hours at the levels relevant to the dietary risk 

assessment. The longer-term exposures could be considered as a series of acute exposures, with 

regard to cholinesterase inhibition. All other effects noted in the sub-chronic and chronic 

toxicity studies were observed at higher doses. Aldicarb is classified as not likely to be 

carcinogenic to humans. 

A Comparative Cholinesterase Assay (CCA) was used to modify the Food Quality Protection 

Act (FQPA) factor for aldicarb (L. Taylor, 7/13/10, D376136). The acute adverse effect of 

cholinesterase inhibition tends to reverse itself within hours following exposure to aldicarb. The 

available toxicological data indicates that aldicarb has an estimated half-life for RBC ChE

inhibition of two hours based on data from rats and human subjects. A summary of the doses 

and endpoints relevant to dietary exposure assessment are shown in Table 4 below.

Table 4. Summary of Toxicological Doses and Endpoints for Aldicarb for Use in Dietary Exposure Risk 

Assessments

Exposure

Scenario

Point of 

Departure

Uncertainty/ 

FQPA Safety 

Factors 1

RfD, PAD, Level 

of Concern

Study and Toxicological 

Effects

Acute Dietary:

(All Populations)

BMDL10

= 0.013 mg/kg

FQPA SF = 

4.8X

UFH = 10

UFA= 1x

Acute RfD = 

aPAD = 0.00027 

mg/kg/day

Human oral study

MRIDs. 43829602, 

45068601, 43442302, 

43442305, 42373001

BMD10 = 0.02 mg/kg, 

based on RBC 

cholinesterase inhibition

Chronic Dietary:

(All Populations)

A quantitative chronic assessment was not conducted because the toxicity database for 

aldicarb indicates that the magnitude of ChEI does not increase with continued 

exposure, due to the reversibility of ChEI (< 24 hours). There are no chronic toxic 

effects more sensitive than ChEI.

Cancer

Classification: Aldicarb is classified as “Not Likely to be Carcinogenic to Humans”, 

based on the lack of evidence of carcinogenicity in studies in rats and mice and the 

absence of a mutagenicity concern.

ChEI = acetylcholinesterase inhibition. Point of Departure (POD) = A data point or an estimated point that is 

derived from observed dose-response data and used to mark the beginning of extrapolation to determine risk 
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associated with lower environmentally relevant human exposures. NOAEL = no observed adverse effect level. 

LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UFA = extrapolation from animal to 

human (interspecies). UFH = potential variation in sensitivity among members of the human population 

(intraspecies). BMD10 = Benchmark Dose; dose that corresponds to 10% response in ChEI. BMDL10 = Benchmark 

Dose estimate based on the lower 95% confidence interval where 10% ChEI would be observed. FQPA SF = FQPA 

Safety Factor. PAD = population adjusted dose. a = acute. RfD = reference dose. MOE = margin of exposure. 

LOC = level of concern. 

VII. Results/Discussion 

As stated above, for acute assessments, HED is concerned when dietary risk exceeds 100% of 

the PAD. The DEEM-FCID analyses estimate the dietary exposure and risk of the U.S. 

population and various population subgroups. The results reported in Table(s) 5, 6, and 7 are for 

the general U.S. Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, 

youth 13-19, females 13-49, adults 20-49, and adults 50-99 years. Acute assessments were 

conducted for food only (Tables 5 and 6), drinking water only (Attachment 3.b.), and food and 

drinking water (Table 6).

A preliminary screening showed that the acute dietary exposure estimates from food alone was

above HED’s level of concern (i.e. >100 % of the aPAD) at the 99.9th percentile of exposure. 

The commodity with highest contribution to the risk was potato which do not have domestic uses 

currently registered. PDP data for potato has contribution from domestic and imported samples. 

This data was modified to eliminate contribution from domestic samples (refer to Section VII for 

additional discussion). An acute dietary assessment using only detects from samples of imported 

potatoes results in risks below the level of concern (<100 % of the aPAD). 

Exposures are above the level of concern (LOC) for drinking water only. Dietary exposure 

estimates ranged from 1,400% to 2,900%, and 150% to 340% of the aPAD at the 99.9th

percentile of exposure for the general population and most population subgroups using the 

scenarios that resulted in the highest EDWC (MN sugar beets) and lowest EDWC (CA Cotton), 

respectively. Similarly, for food and drinking water, the dietary exposure is above HED’s LOC 

using drinking water scenarios that provided the highest EDWC (MN sugar beets), see Table 6.

Table 5. Results of Acute Dietary (Food with Imported Potatoes Only) Exposure and Risk Analysis.

Population Subgroup aPAD 

(mg/kg/day)

95th Percentile 99th Percentile 99.9th Percentile

Exposure 

(mg/kg/day)

% 

aPAD

Exposure 

(mg/kg/day)

% 

aPAD

Exposure 

(mg/kg/day)

% 

aPAD

General U.S. Population

0.00027

0.000006 2.2 0.000024 8.7 0.000067 25

All Infants (<1 year old) 0.000023 8.5 0.000043 16 0.000089 33

Children 1-2 years old* 0.000012 4.6 0.000071 26 0.000177 65

Children 3-5 years old 0.000010 3.6 0.000053 20 0.000133 49

Children 6-12 years old 0.000005 2.0 0.000032 12 0.000076 28

Youth 13-19 years old 0.000003 1.3 0.000022 8.0 0.000050 18

Adults 20-49 years old 0.000004 1.6 0.000020 7.2 0.000044 16

Adults 50-99 years old 0.000007 2.8 0.000022 8.1 0.000049 18

Females 13-49 years old 0.000004 1.6 0.000020 7.0 0.000046 17

* The population with the highest risk estimate is in bold.
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Table 6. Summary of Acute Dietary (Food Only, and Food and Drinking Water) Exposure and Risk 

for Aldicarb at the 99.9th Percentile of Exposure.

Population Subgroup

Water Only for CA 

Cotton Scenario

Water Only for MN 

Sugar Beets Scenario

Food and Water for MN 

Sugar Beets Scenario

Dietary 

Exposure 

(mg/kg/day)

% aPAD

Dietary 

Exposure

(mg/kg/day)

% aPAD

Dietary 

Exposure

(mg/kg/day)

% aPAD

General U.S. Population 0.000492 180 0.004616 1700 0.004607 1700

All Infants (<1 year old)* 0.000909 340 0.007775 2900 0.007723 2900

Children 1-2 years old 0.000743 280 0.006928 2600 0.006976 2600

Children 3-5 years old 0.000628 230 0.005760 2100 0.005750 2100

Children 6-12 years old 0.000446 170 0.004206 1600 0.004220 1600

Youth 13-19 years old 0.000396 150 0.003696 1400 0.003664 1400

Adults 20-49 years old 0.000501 190 0.004677 1700 0.004672 1700

Adults 50-99 years old 0.000448 170 0.004186 1600 0.004155 1500

Females 13-49 years old 0.000498 180 0.004688 1700 0.004677 1700

* The population with the highest risk estimate is in bold.

VIII. Characterization of Inputs/Outputs

HED has conducted mostly refined acute dietary exposure and risk assessments for aldicarb and 

its metabolites. The assumption with respect to food made in this acute dietary assessment 

include the latest PDP monitoring data, anticipated residues, empirical processing factors, default 

DEEM processing factors, and percent crop treated when available. Moreover, the percent of 

commodity imported was considered for potato, grapefruit, lemons, oranges, coffee and pecans. 

Dietary assessments for food plus drinking water and drinking water only show that drinking 

water was a main driver for the U.S. general population and all population subgroups. These 

factors resulted in the acute aggregate (food and drinking water) dietary exposure estimates to be 

above HED’s level of concern.

A screening for food only showed risk of concern; therefore, a critical exposure contribution 

analysis was conducted. This analysis showed that risks of concern for food only were mainly 

associated with consumption of potato tuber. PDP data for potato used in this dietary assessment 

was generated from 2006 to 2009. Because the use of aldicarb on potato was eliminated from 

the U.S.A. label on August 16, 2010 (EPA Reg. No. 264-330, label currently inactive), the PDP 

data used represents domestic and imported potatoes treated with aldicarb. To refine the dietary 

exposure, a dietary assessment was done for food only considering only the detected samples 

from imported potato, see Table 6. This analysis was prepared by modifying the two RDF files 

for potato, with and without peel, to include only the samples of potato that were imported. 

USDA PDP analyzed 31 samples of imported potato with peel (2008 and 2009 monitoring) 

resulting in one detect, and 318 samples of imported frozen potatoes without peel (2006 and 

2007 monitoring) resulting in zero detects. The percent of imported potatoes with peel that were 

analyzed (2%) is smaller than the percent of imports reported by BEAD (8%) while the percent 

of imported frozen potatoes without peel that were analyzed is identical to that reported by 

BEAD (21%). Overall, HED understand that these RDF files are more representative of the 

current situation than those that include the results of domestic samples. This refinement results 

in a dietary risk for food only below the level of concern, 25% of the aPAD for the general 
Aldicarb Dietary Exposure and Risk Assessment DP Number: D430197

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population, and 65% of the aPAD for children 1-2 years old, the highest exposed population 

subgroup.

Overall, the dietary assessments for food only could be refined if percent of crop treated data for 

the imported commodities were available. Although dietary risk estimates for food are below 

HED’s level of concern, note that drinking water is the main contributor to the dietary exposure, 

as such, it has to be considered in aggregate dietary assessment in support of domestic uses of 

aldicarb. For measures to address the dietary risk associated with residues of aldicarb in drinking 

water refer to EFED memo (E. Wong, D427697, 06/17/2015). Mitigation measures discussed in 

2010 (revocation of tolerances for pecan, sorghum and sugarcane, and removing uses on citrus 

and potato) may be necessary to accommodate exposure to drinking water as deemed necessary. 

The results of a DEEM-FCID acute dietary risk assessment vary due to the random selection of 

residues performed during the Monte Carlo procedure. Dietary exposures at the per capita 99.9th

percentile may vary between 1% and 3% when different random seeds are used in a DEEMFCID acute assessment. This effect generally differs for different subpopulations: e.g., the results 

for infants may increase, while the results for children 1-2 years old decrease. Those slight 

variations often lead to the unintuitive result that aggregate Food + Drinking Water dietary 

exposure estimates are lower than exposure estimates for Drinking Water alone for particular 

subgroup(s). We are most likely to observe such results when food provides relatively small 

contributions among high-end outcomes. The relative contributions from Food can be assessed 

by a detailed inspection of all high-end person-day outcomes (99.9th– 100th percentiles), or 

indirectly inferred when the results for Food + Drinking Water are similar to the results for 

drinking water alone, as is the case for aldicarb-MN Sugar beets.

IX. Commodity Specific Analysis

Commodity specific analysis (CSA) was conducted for aldicarb to obtain estimates of the acute 

exposure and risk following a single consumption event for potatoes and for sweet potatoes. 

Dietary exposures were calculated using typical serving sizes for amounts consumed and USDA 

PDP monitoring data. While aldicarb is no longer used domestically on potatoes, tolerances 

remain in place which allows import into the U.S. of potatoes containing aldicarb residues. 

Dietary exposures were expressed as a percent of the acute population adjusted dose (0.00027 

mg/kg/day). 

Table E.2 summarizes the commodity specific analysis for aldicarb. The highest %aPAD were 

for pre-school age children eating the equivalent of one average size potato (130% aPAD) or 

sweet potato (300% aPAD). This CSA is considered a highly refined assessment for the 

following reasons:

 The aPAD was calculated using: 

o an endpoint/NOAEL from a human study (the inter-species factor was reduced to 

1X), 

o a 4.8X data-derived factor for children, and

o a 10X intra-species factor;
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 PDP monitoring data were used to estimate residues, and processing/cooking data was 

considered, as appropriate. 

A cooking factor of 1x was applied based on empirical data. Although processing factors of 0.5 

(boiled, canned:cooked, canned:boiled) and 0.62 (fried) are available for sweet potato or potato, 

these do not apply to cooked baked sweet potato. Also, because aldicarb is applied as a soilincorporated, granular formulation, residues may be significantly higher in individual potatoes or 

sweet potatoes relative to residues measured in the PDP samples, which are composites of many 

individual potatoes, i.e., the composite samples represent an average residue in all of the potatoes 

in the analyzed sample, whereas all of the residue may actually be present in only a subset of the 

individual potatoes. In fact, limited residue data available indicate that residues of aldicarb and 

its metabolites in the individual samples could be at least 2.4 times that of the composite sample 

suggesting that the CSA risk estimates may underestimate actual risks from consumption of 

individual potatoes or sweet potatoes. 

For these reasons, the conservative inputs used to estimate the aldicarb CSA risks should be 

considered marginal, with risk estimates closely approximating actual potential risks to the small 

portion of the U.S. population consuming commodities containing residues at these levels. 

Sweet Potato

The PDP monitoring data (2008-2010) for sweet potatoes show two detects, 0.07784 ppm and 

0.06894 ppm of 1476 samples of unpeeled sweet potato, that are above the threshold (i.e. residue 

level that would result in risk at the level of concern) for preschoolers (0.026 ppm). PDP 

monitoring data is available for sweet potato baby food which showed no detects above the limit 

of detection of 0.0083 ppm. This results in exposures below the level of concern for infants, 

24% of the aPAD. The dietary exposure is above HED’s level of concern (i.e. >100% of the 

aPAD) for preschoolers consuming one medium size sweet potato (157 g); exposure is 300% of 

the aPAD. Exposures are below the level of concern for adults consuming one medium size 

sweet potato (75% of the aPAD).

Potato

PDP monitoring data for imported potatoes were used in the CSA; domestically cultivated potato 

data from 2006-2009 PDP monitoring were excluded since aldicarb is not registered for use in 

the U.S. as part of the 2010 mitigation. PDP monitoring data generated after cancelation of the 

U.S.A. use on potato is not available at this time. The dietary exposure do not exceed the level 

of concern for infants (100% of the aPAD) consuming 1⁄2 medium size potato (71 g), is above 

HED’s level of concern for preschoolers (130% of the aPAD) consuming one medium size sweet 

potato (142 g), and is below the level of concern for adults consuming 1 medium size potato 

(33% of the aPAD).

X. Conclusions

Risks are below the level of concern for food only after refinement considering PDP data for 

imported potatoes; however, the commodity specific analysis results in exposure estimates above 
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100% of the aPAD following consumption of an estimated single serving of sweet potato and 

potatoes. The aggregate (food and drinking water) acute analysis demonstrate that the registered 

uses for aldicarb result in risk of concern for the general U.S. population and all population 

subgroups. Overall, the dietary risk is mainly associated with drinking water; refer to EFED 

memo for mitigation measures and Attachment 4 for estimates of drinking level of comparison. 

HED is confident that the assessment does not underestimate risk to the general U.S. population 

or any population subgroup.

XI. List of Attachments

Attachment 1. Data and Residue Estimates Used in the Dietary Exposure Analyses

Attachment 2. SLUA for Aldicarb

Attachment 3. Aldicarb Input and Result Files

Attachment 4. EDWC at the LOC Considering Exposure through Drinking Water Only

Attachment 5. Commodity Specific Analysis Conducted for Aldicarb
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Attachment 1. Data and Residue Estimates Used in the Dietary Exposure Analyses

Table A.1.1. Summary of PDP Data for Aldicarb and its Sulfone and Sulfoxide Metabolites.*

Number of Samples Analyzed

Commodity 2006 2007 2008 2009 2010 2011 2012

Potato w/peel 

uncooked 744 744

Potato w/o peel 

frozen 744 800

Sweet Potato 184 739 533

Sweet Potato 

Baby Food 191 585

Orange 744 744

Orange Juice 191 199 330

* The three residues of concern were measured in each sample.

A.1.2. PDP Data for Select Commodities

Commodity

PDP Total Samples PDP Total Detects

Total Domestic

Imports or 

Unknown Total Domestic

Imports or 

Unknown

Potato (2008, 2009) 1488 1457 31 62 61 1

Potato-Frozen (2006, 2007) 1544 1226 318 93 93 0

Sweet Potatoes (2008, 2009, 2010) 1476 1458 18 5 4 1

Sweet Potatoes baby food (2010, 2011) 776 771 5 0 0 0

Oranges (2009, 2010) 1488 1365 123 5 4 0

Grapefruit (2005, 2006) 1462 1441 21 5 5 0
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Table A.1.3. Data and Residue Estimates Used in the Dietary Exposure Analyses.

RAC Food

Forms

Blending

Classification1

Data

Source2

No. of

Samples

No. of

Detectable

Residues3

1⁄2 LOD

%CT4

or % 

Import*

Processing

Factors

Anticipated Residue 

Estimates/Tolerance

Acute (Tol., AR, 

RDF)2

Potato, chips

Potato, fried All B

PDP Potato 

w/peel 

2008/2009

1488 62/1 0.0052 8* 0.62 0.000437 (Import)

Potato, dry All B

PDP Potato 

w/peel 

2008/2009

1488 62/1 0.0052 8* 6.5 0.000437 (Import)

Potato, dry, 

baby food (bf) All B

PDP Potato 

w/peel 

2008/2009

1488 62/1 0.0052 8* 6.5 0.000437 (Import)

Potato, flour All B

PDP Potato 

w/peel 

2008/2009

1488 62/1 0.0052 8* 6.5 0.000437 (Import)

Potato, flour bf All B

PDP Potato 

w/peel 

2008/2009

1488 62/1 0.0052 8* 6.5 0.000437 (Import)

Potato, tuber, 

w/peel

Boiled NB

PDP Potato 

w/peel 

2008/2009

1488 62/1 0.0052 8* 0.5 RDF 1

Canned :Cooked; 

Canned :Boiled PB

PDP Potato 

w/peel 

2008/2009

1488 62/1 0.0052 41* 0.5 RDF 14

All Others PB/NB

PDP Potato 

w/peel 

2008/2009

1488 62/1 0.0052 8* RDF 1

Potato, tuber, 

w/peel bf Canned:Cooked PB/NB

PDP Potato 

w/peel 

2008/2009

1488 62/1 0.0052 8* 0.5 RDF 1

Potato, tuber, 

w/o peel

Boiled; Canned:Cooked; 

Canned :Boiled PB/NB

PDP Potato 

w/peel 

2008/2009

1488 62/1 0.0052 8* 0.5 RDF 1

Frozen Baked (FB)

Frozen Fried PB/NB

PDP Potato 

w/o peel 

2006/2007

1544 93/0 0.0041 21* RDF 2
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All Others PB/NB

PDP Potato 

w/peel 

2008/2009

1488 62/1 0.0052 8* RDF 1

Potato, tuber, 

w/o peel, bf Cooked :Canned PB/NB

PDP Potato 

w/peel 

2008/2009

1488 62/1 0.0052 8* 0.5 RDF 1

Sweet potato Boiled; Canned :Cooked; 

Canned :Boiled PB/NB

PDP Sweet 

potato

2008-2010

1476 5 0.0109 100 0.5 RDF 3

All Others PB/NB

PDP Sweet 

potato

2008-2010

1476 5 0.0109 100 RDF 3

Sweet potato, 

bf

Cooked :Fresh PB/NB

PDP Sweet 

potato

2010/2011

776 0 0.0083 100 RDF 4

Cooked :Canned PB/NB

PDP Sweet 

potato

2010/2011

776 0 0.0083 100 0.5 RDF 4

Soybean, seed All B

FTD 

D299883 2.5 0.00855 Mean 0.000214 AR

Soybean, soy 

milk All B

FTD 

D299883 2.5 0.00855 Mean 0.000214 AR

Soybean, soy 

milk, bf All B

FTD 

D299883 2.5 0.00855 Mean 0.000214 AR

Soybean, oil All B

FTD 

D299883 2.5 0.3 0.00855 Mean 0.000214 AR

Soybean, oil, 

bf All B

FTD 

D299883 2.5 0.3 0.00855 Mean 0.000214 AR

Soybean, flour All B

FTD

D299883 2.5 0.00855 Mean 0.000214 AR

Soybean, flour, 

bf All B

FTD 

D299883 2.5 0.00855 Mean 0.000214 AR

Bean, black, 

seed

Baked, boiled, fried, 

canned:cooked; 

canned:boiled; cooked:NS

B

FTD 

D299883 2.5 0.05 0.00855 Mean 0.000214 AR

Bean, broad, 

seed

Baked, boiled, fried, 

canned:cooked; 

canned:boiled; cooked:NS

B

FTD 

D299883 2.5 0.05 0.00855 Mean 0.000214 AR
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Bean, cowpea, 

seed

Baked, boiled, fried, 

canned:cooked; 

canned:boiled; cooked:NS

B

FTD 

D299883 2.5 0.05 0.00855 Mean 0.000214 AR

Bean, great 

northern, seed

Baked, boiled, fried, 

canned:cooked; 

canned:boiled; cooked:NS

B

FTD 

D299883 2.5 0.05 0.00855 Mean 0.000214 AR

Bean, kidney, 

seed

Baked, boiled, fried, 

canned:cooked; 

canned:boiled; cooked:NS

B

FTD 

D299883 2.5 0.05 0.00855 Mean 0.000214 AR

Bean, lima, 

seed

Baked, boiled, fried, 

canned:cooked; 

canned:boiled; cooked:NS

B

FTD 

D299883 2.5 0.05 0.00855 Mean 0.000214 AR

Bean, mung, 

seed

Baked, boiled, fried, 

canned:cooked; 

canned:boiled; cooked:NS

B

FTD 

D299883 2.5 0.05 0.00855 Mean 0.000214 AR

Bean, navy, 

seed

Baked, boiled, fried, 

canned:cooked; 

canned:boiled; cooked:NS

B

FTD 

D299883 2.5 0.05 0.00855 Mean 0.000214 AR

Bean, pink, 

seed

Baked, boiled, fried, 

canned:cooked; 

canned:boiled; cooked:NS

B

FTD 

D299883 2.5 0.05 0.00855 Mean 0.000214 AR

Bean, pinto, 

seed

Baked, boiled, fried, 

canned:cooked; 

canned:boiled; cooked:NS

B

FTD 

D299883 2.5 0.05 0.00855 Mean 0.000214 AR

Chickpea, seed

Baked, boiled, fried, 

canned:cooked; 

canned:boiled; cooked:NS

B

FTD 

D299883 2.5 0.05 0.00855 Mean 0.000214 AR

Orange All NB/PB PDP Orange

2009/2010 1488 4 0.0131 8* RDF 9_O_Modif 8 Perc Imports

Orange, juice All PB

PDP Orange 

Juice 2010/

2011/2012

1106 5 0.0042 8* RDF 10_OJ_Modif 

8 Perc Imports

Orange, juice, 

bf All PB

PDP Orange 

Juice 2010/

2011/2012

1106 5 0.0042 8* RDF 10_OJ_Modif 

8 Perc Imports

Orange, peel All PB PDP Orange

2009/2010 1488 4 0.0131 8* RDF 9_O_Modif 8 Perc Imports

Lemon All NB/PB PDP Orange

2009/2010 1488 4 0.0131 10* RDF 9_O_Modif 10 Perc Lemon Imports
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Lemon, juice All PB

PDP Orange 

Juice 2010/

2011/2012

1106 5 0.0042 10*

RDF 10_OJ_Modif 

10 Perc Lemon 

Import

Lemon, peel All PB PDP Orange

2009/2010 1488 4 0.0131 10* RDF 9_O_Modif 10 Perc Lemon Imports

Lime All NB PDP Orange

2009/2010 1488 4 0.0131 100 RDF 9

Lime, juice All PB

PDP Orange 

Juice 2010/

2011/2012

1106 5 0.0042 100 RDF 10

Lime, juice, bf All PB

PDP Orange 

Juice 2010/

2011/2012

1106 5 0.0042 100 RDF 10

Grapefruit All NB/PB PDP Orange

2009/2010 1488 4 0.0131 2* RDF 9_O_Modif 2 Perc Grapefruit Imp

Grapefruit, 

juice All PB

PDP Orange 

Juice 2010/

2011/2012

1106 5 0.0042 2*

RDF 10_OJ_Modif 

2 Perc Grapefruit 

Imports

Pecan All PB FTD 

D299883 22 58* RDF 13

Sorghum, 

grain All B Tolerance 100 0.2

Sorghum, 

syrup

All B Tolerance 100 0.2

Cottonseed, oil All B

FTD 

D425180 35 0.1 0.0453 Mean0.0159 AR

Cottonseed, 

oil, bf All B

FTD 

D425180 35 0.1 0.0453 Mean0.0159 AR

Coffee, roasted 

bean All B

FTD 

D299883 100 0.00855

Coffee, instant All B

FTD 

D299883 100 0.00855

Peanut All B

FTD 

D299883 45 0.0047 Mean0.002115 AR

1. Classification: blended (B), partially blended (PB), not blended (NB).

2. Field Trial Data (FTD); Residue Distribution File (RDF); Anticipated Residue (AR); Baby food (bf); with (w); without (w/o); Orange (O); Orange Juice (OJ).
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Table A.1.4. RDF Files and Point Estimate Calculations

Refinement for Potatoes (Import Samples Only)

RDF 1_Potato_wPeel_

Uncooked_1_Imports.rdf

PDP Data: POFR (2008,2009), 

Total Samples=1488, Total 

Detects=1, Total LODs=118, Total 

Zeros=1369; 8% Imported 

Potatoes, Avg Residue 

(Detects)=0.083327, Avg Residue 

(TOTALS)=0.0085, Avg Residue 

Avg HLOD (NonDetects)=0.0052

TOTALZ=1369

TOTALLOD=118

LODRES=0.0052

0.03796

RDF 2_Potato_wopeel_Frozen_

Baked_2_Imports.rdf

PDP Data: PZFZ (2006,2007), Total 

Samples=1544, Total Detects=0, 

Total LODs=324, Total Zeros=1220

21% of Imported Potatoes, Avg 

Residue (Detects)=0.011659, Avg 

Residue (TOTALS)=0.0045, Avg 

HLOD (NonDetects)=0.0041

TOTALZ=1220

TOTALLOD=324

LODRES=0.0041

Potato Blended Processed 

Commodities: Anticipated 

Residues

Residue estimate for a blended 

processed commodity based on 

monitoring data and % of imports.

PDP Data for Potato with Peel 

Uncooked: POFR (2008, 2009), 

Total Samples=1488, Total 

Detects=1, Sum of 

Detects=0.03796 ppm, Total 

LODs=118, Avg HLOD=0.0052; 

8% of Imported Potatoes.

Total Samples with Residues = 119

1⁄2LOD = 0.0052 ppm

Total Samples 1⁄2 LOD = 118

Sum of Detects = 0.03796 ppm

Anticipated residue: 0.000437 ppm 

[(118 samples*0.0052 ppm + 

0.03796 ppm)/1488]

RDF 14_Potato_wPeel_

Uncooked_Canned_14_Imports.rdf

PDP Data: POFR (2008,2009), 

Total Samples=1488, Total 

Detects=1, Total LODs=609, Total 

Zeros=878; 41% Imported 

Potatoes, Avg Residue 

(Detects)=0.083327, Avg Residue 

(TOTALS)=0.0085, Avg Residue 

Avg HLOD (NonDetects)=0.0052

TOTALZ=878

TOTALLOD=609

LODRES=0.0052

0.03796

All Other RDFs
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RDF 3_Potato_Sweet_3.rdf

PDP Data: SWFR 

(2008,2009,2010), Total 

Samples=1476, Total Detects=5, 

Total LODs=1471, Total Zeros=0

MaxPCT=100, Avg Residue 

(Detects)=0.038920, Avg Residue 

(TOTALS)=0.0017, Avg Residue 

(Blended, PCT=100)=0.010967, 

Avg HLOD (NonDetects)=0.0109

TOTALZ=0

TOTALLOD=1471

LODRES=0.0109

0.07784

0.06594

0.02126

0.01478

0.01478

RDF 4_Potato_Sweet_4.rdf

PDP Data: ISGJ,ISPC,ISSE; Baby 

food; (2010,2011), Total 

Samples=776, Total Detects=0, 

Total LODs=116, Total Zeros=0

MaxPCT=100, Avg Residue 

(Detects)=., Avg Residue 

(TOTALS)=0.0012, Avg Residue 

(Blended, PCT=100)=0.008340, 

Avg HLOD (NonDetects)=0.0083

TOTALZ=0

TOTALLOD=776

LODRES=0.0083

Soybean and Dry Bean: 

Anticipated Residues

Average residue values reported in 

D299883 (C. Olinger, 08/16/2010) 

were used. The %CT for soybean 

and dry beans is 2.5%.

Average residue: 0.00855 ppm

Anticipated residue: 0.000214 ppm 

[0.00855 ppm x 0.025 (fraction of 

crop treated)]

RDF 9_Orange_9.rdf

PDP Data: OGFR (2009,2010), 

Total Samples=1488, Total 

Detects=4, Total LODs=1484, 

Total Zeros=0; MaxPCT=1.000, 

Avg Residue (Detects)=0.018950, 

Avg Residue (TOTALS)=0.0131, 

Avg Residue (Blended, 

PCT=100)=0.013133, Avg HLOD 

(NonDetects)=0.0131

TOTALZ=0

TOTALLOD=1484

LODRES=0.0131

0.02126

0.02034

0.01942

0.01478

RDF 9_Orange_9_Modified_8Perc 

Imports.rdf

PDP Data: OGFR (2009,2010), 

Total Samples=1488, Total 

Detects=4, Total LODs=115, Total 

Zeros=1369; 8% Imports, Avg 

Residue (Detects)=0.018950, Avg 

Residue (TOTALS)=0.0131, Avg 

HLOD (NonDetects)=0.0131

TOTALZ=1369

TOTALLOD=115

LODRES=0.0131

0.02126

0.02034

0.01942

0.01478

RDF 9_Orange_9_Modified

_10Perc Lemon Import.rdf

PDP Data: OGFR (2009,2010), 

Total Samples=1488, Total 

Detects=4, Total LODs=145, Total 

Zeros=1339; 10% Imports, Avg 

Residue (Detects)=0.018950, Avg 

Residue (TOTALS)=0.0131, Avg 

HLOD (NonDetects)=0.0131

TOTALZ=1339

TOTALLOD=145

LODRES=0.0131

0.02126

0.02034

0.01942

0.01478

RDF 9_Orange_9_Modified_2Perc 

Grapefruit Import.rdf

PDP Data: OGFR (2009,2010), 

Total Samples=1488, Total 

Detects=4, Total LODs=26, Total 

Zeros=1458; 2% Imports, Avg 

Residue (Detects)=0.018950, Avg 

Residue (TOTALS)=0.0131, Avg 

HLOD (NonDetects)=0.0131

TOTALZ=1458

TOTALLOD=26

LODRES=0.0131

0.02126

0.02034

0.01942

0.01478

RDF 10_Orange_Juice_10.rdf

PDP Data: OJCO,OJFZ,OJRE 

(2010,2011,2012), Total 

Samples=1106, Total Detects=5, 

Total LODs=1101, Total Zeros=0

MaxPCT=1.000, Avg Residue 

(Detects)=0.006102, Avg Residue 

(TOTALS)=0.0042, Avg Residue 

(Blended, PCT=100)=0.004179, 

Avg HLOD (NonDetects)=0.0042

TOTALZ=0

TOTALLOD=1101

LODRES=0.0042

0.00647

0.00647

0.00647

0.00555

0.00555

RDF 10_Orange_Juice_10_

Modified 8Perc Imports.rdf

PDP Data: OJCO,OJFZ,OJRE 

(2010,2011,2012), Total 

Samples=1106, Total Detects=5, 

Total LODs=83, Total Zeros=1018

8% Imports, Avg Residue 

(Detects)=0.006102, Avg Residue 

(TOTALS)=0.0042, Avg HLOD 

(NonDetects)=0.0042

TOTALZ=1018

TOTALLOD=83

LODRES=0.0042

0.00647

0.00647

0.00647

0.00555

0.00555
Aldicarb Dietary Exposure and Risk Assessment DP Number: D430197

Page 22 of 34

RDF 10_Orange_Juice_10_

Modified_10Perc Lemon 

Imports.rdf

PDP Data: OJCO,OJFZ,OJRE 

(2010,2011,2012), Total 

Samples=1106, Total Detects=5, 

Total LODs=106, Total Zeros=995; 

10% Imports, Avg Residue 

(Detects)=0.006102, Avg Residue 

(TOTALS)=0.0042, Avg HLOD 

(NonDetects)=0.0042

TOTALZ=995

TOTALLOD=106

LODRES=0.0042

0.00647

0.00647

0.00647

0.00555

0.00555

RDF 10_Orange_Juice_10_ 

Modified_2Perc Grapefruit 

Imports.rdf

PDP Data: OJCO,OJFZ,OJRE 

(2010,2011,2012), Total 

Samples=1106, Total Detects=5, 

Total LODs=17, Total Zeros=1084,

2% Imports, Avg Residue 

(Detects)=0.006102, Avg Residue 

(TOTALS)=0.0042, Avg HLOD 

(NonDetects)=0.0042

TOTALZ=1084

TOTALLOD=17

LODRES=0.0042

0.00647

0.00647

0.00647

0.00555

0.00555

RDF 13_Pecan_13.rdf

Pecan Aldicarb FTD; 22 Samples

Field Trial Residue Data [MRID 

No. 102123]

58% Imported Pecan

TOTALZ=16

4,0.0043 

2,0.0171 

2,0.0256 

2,0.0427 

2,0.00855 

0.0342 

0.0684 

0.0598 

0.0513 

0.0769 

0.0940 

0.0855 

0.231 

0.103 

0.145

Cotton seed oil: Anticipated 

Residues

Residue estimate for a blended 

commodity based on crop field trial 

data.

Mean residue: 0.0453 ppm 

Anticipated residue: 0.0159 ppm 

[0.0453 ppm x 0.35 (fraction of 

crop treated)]
Aldicarb Dietary Exposure and Risk Assessment DP Number: D430197

Page 23 of 34

Attachment 2. Import Usage and SLUA for Aldicarb

A.2.1. Import Usage for Commodities with Tolerances and No U.S.A. Registration

The following report was provided by the Biological and Economic Analysis Divison (D. 

Atwood, e-mails received on 11/25/2015 and on 12/28/2015).

Aldicarb Import Usage (Average 2009-2013)

US 

Production 

(million lbs)

Commodity 

Export 

(million lbs)

Available 

domestic 

(million lbs)

Commodity 

Imports 

(million lbs)

Total 

Available for 

consumption 

(million lbs)

% Import 

Component

Grapefruit 1,304.8 489.2 815.6 20 835.6 2%

Lemons 1155.2 210.6 944.6 100.8 1,045.4 10%

Limes 0 6 -6.0 833.8 827.8 101%*

Orange 4289.2 1449.3 2,839.9 245.1 3,085.0 8%

Pecans 133753 75107 58646 82459 141105 58%

Coffee 7.8 388.2 -380.4 3359.7 2979.3 113%*

Potatoes 11010 972 10038 910 10948 8%

Citrus dry pulp Data not available

Sorghum, grain, 

bran Data not available

Sorghum, grain, 

grain Data not available

Sorghum, grain, 

stover Data not available

Sugarcane, cane Data not available

Source: USDA/ERS. 2015. Food Availability (Per Capita) Data System

http://www.ers.usda.gov/data-products/food-availability-(per-capita)-data-system.aspx#.Up9c9dLkvMY

* For limes and coffee, a 100% of import component was used for dietary assessment purposes.

US 

Production 

(million lbs)

Commodity 

Export 

(million lbs)

Available 

domestic 

(million lbs)

Commodity 

Imports 

(million lbs)

Total 

Available for 

consumption 

(million lbs)

% Import 

Component

Potatoes (Fresh) 11020.1 923.2 10096.9 915.2 11012.1 8%

Potaotes (Freezing) 15744.4 3707.6 12036.8 3285.7 15322.5 21%

Potatoes (Canning) 239.3 106.2 133.1 91.9 225 41%

Potatoes (Chips) 5411.3 461.3 4950 106.9 5056.9 2%

Potaotes (Dehydrated) 4364 1114.7 3249.3 532.9 3782.2 14%

Potatoes (Total) 36779.2 6313.1 30466.1 4932.6 35398.7 14%

A.2.2. Screening Level Usage Analysis for Aldicarb
Aldicarb Dietary Exposure and Risk Assessment DP Number: D430197

Page 24 of 34

Aldicarb (098301)

Screening Level Usage Analysis (SLUA)

Date: December 18, 2014

What is a Screening Level Usage Analysis (SLUA)?

 Available estimates of pesticide usage data for a particular active ingredient that is 

used on agricultural crops in the United States.

 Pesticide usage data obtained from various sources. The data are then merged, 

averaged, and rounded so that the presented information is not proprietary, business 

confidential, or trade secret. 

What does it contain?

 Pesticide usage data for a single active ingredient only.

 Agricultural use sites (crops) that the pesticide is reported to be used on.

 Available pesticide usage information from U.S. states that produce 80% or more of a 

crop, in most cases, or less than 80%, in rare cases, depending on the scope of the 

survey and available resources.

 Annual percent of crop treated (average & maximum) for each agricultural crop.

 Average annual pounds of the pesticide applied for each agricultural crop (i.e., for the 

states surveyed, not for the entire United States).

What assumptions can I make about the reported data?

 Average pounds of active ingredient applied - Values are calculated by merging 

pesticide usage data sources together; averaging across all observations, then 

rounding. Note: If the estimated value is less than 500, then that value is labeled 

<500. Estimated values between 500 & <1,000,000 are rounded to 1 significant 

digit. Estimated values of 1,000,000 or greater are rounded to 2 significant digits.)

 Average percent of crop treated - Values are calculated by merging data sources 

together; averaging by year, averaging across all years, & rounding to the nearest 

multiple of 5. Note: If the estimated value is less than 2.5, then the value is labeled 

<2.5. If the estimated value is less than 1, then the value is labeled <1.

 Maximum percent of crop treated - Value is the single maximum value reported 

across all data sources, across all years, & rounded up to the nearest multiple of 5. 

Note: If the estimated value is less than 2.5, then the value is labeled <2.5.

What are the data sources used?

 USDA-NASS (United States Department of Agriculture’s National Agricultural 

Statistics Service) – pesticide usage data from 2004 to 2012.

 Private pesticide market research – pesticide usage data from 2004 to 2012.

 California Department of Pesticide Regulation (DPR) Pesticide Use Reporting

(PUR) data for 2004 to 2011.

What are the limitations to the data?

 Additional registered uses may exist but are not included because the available 

surveys do not report usage (e.g., small acreage crops).

 Lack of reported usage data for the pesticide on a crop does not imply zero usage.

 Usage data on a particular site may be noted in data sources, but not quantified. In 

these instances, the site would not be reported in the SLUA.
Aldicarb Dietary Exposure and Risk Assessment DP Number: D430197

Page 25 of 34

 Non-agricultural use sites (e.g., turf, post-harvest, mosquito control, etc.) are not 

reported in the SLUA. A separate request must be made to receive these estimates.

 Some sites show some use, even though they are not on the label. This usage could 

be due to various factors, including, but not limited to Section 18 requests, existing 

stocks of the chemical, data collection errors, and experimental use permits (EUPs). 
Aldicarb Dietary Exposure and Risk Assessment DP Number: D430197

Page 26 of 34

 

December 18, 2014

Screening Level Estimates of Agricultural Uses of Aldicarb (098301)

Sorted Alphabetically

(Reporting Timeframe: 2004-2012)

Percent Crop Treated

Crop

Average 

Lbs. A.I. Average Maximum

1 Almonds+ 2,000 <1 <2.5

2 Cantaloupes+ <500 <1 <2.5

3 Cotton 1,600,000 20 35

4 Dry Beans/Peas 10,000 <2.5 <2.5

5 Grapefruit+ 100,000 35 55

6 Lemons+ <500 <1 <2.5

7 Oranges+ 500,000 15 35

8 Peanuts 400,000 35 45

9 Pecans+ 10,000 <2.5 <2.5

10 Potatoes+ 200,000 5 15

11 Sorghum+ 2,000 <1 <2.5

12 Soybeans 60,000 <1 <2.5

13 Sugar Beets 100,000 5 10

14 Sugarcane+ 7,000 <2.5 <2.5

15 Tangerines+ 6,000 5 5

16 Tobacco+ 20,000 5 10

17 Watermelons+ <500 <1 <2.5

All numbers rounded.

<500 Less than 500 pounds of active ingredient

<2.5 Less than 2.5 percent of crop treated

<1 Less than 1 percent of crop treated

+ There is no current active registration for this use. 

SLUA data sources include: 

USDA-NASS (United States Department of Agriculture's National Agricultural Statistics Service) 

Private Pesticide Market Research

These results reflect amalgamated data developed by the Agency and are releasable to the public.
Aldicarb Dietary Exposure and Risk Assessment DP Number: D430197

Page 27 of 34

Attachment 3. Aldicarb Input and Result Files

A) Input File for Food (Refined Potato Imports) + Drinking Water (Sugar beet)

Filename: C:\Users\IEncarna\Dietary Assessments\Aldicarb\DEEM Files\Aldicarb Acute_Food 

Water SugarBeet_Refined_PotatoImports.r08

Chemical: Aldicarb Acute Dietary Assessment

RfD(Chronic): 0 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .00027 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 02-18-2016/10:43:52 Program ver. 3.16, 03-08-d

-----------------------------------------------------------------------------------

RDL indices and parameters for Monte Carlo Analysis:

Index Dist Parameter #1 Param #2 Param #3 Comment

 # Code 

----- ---- ------------ -------- -------- -------

 1 6 C:\Users\IEncarna\Dietary 

Assessments\Aldicarb\Scenario2\Potato_wPeel_Uncooked_1_Imports.rdf

 2 6 C:\Users\IEncarna\Dietary 

Assessments\Aldicarb\Scenario2\Potato_wopeel_Frozen_Baked_2_Imports.rdf

 3 6 C:\Users\IEncarna\Dietary Assessments\Aldicarb\Scenario2\Potato_Sweet_3.rdf

 4 6 C:\Users\IEncarna\Dietary Assessments\Aldicarb\Scenario2\Potato_Sweet_BF_4.rdf

 5 6 C:\Users\IEncarna\Dietary Assessments\Aldicarb\Scenario2\Orange_9_Modified 8Perc 

Import.rdf

 6 6 C:\Users\IEncarna\Dietary 

Assessments\Aldicarb\Scenario2\Orange_Juice_10_Modified 8 Perc Imports.rdf

 7 6 C:\Users\IEncarna\Dietary Assessments\Aldicarb\Scenario2\Orange_9_Modified 

10Perc Lemon Import.rdf

 8 6 C:\Users\IEncarna\Dietary 

Assessments\Aldicarb\Scenario2\Orange_Juice_10_Modified 10 Perc Lemon Imports.rdf

 9 6 C:\Users\IEncarna\Dietary Assessments\Aldicarb\Scenario2\Orange_9.rdf

 10 6 C:\Users\IEncarna\Dietary Assessments\Aldicarb\Scenario2\Orange_Juice_10.rdf

 11 6 C:\Users\IEncarna\Dietary Assessments\Aldicarb\Scenario2\Orange_9_Modified 2Perc 

Grapefruit Import.rdf

 12 6 C:\Users\IEncarna\Dietary 

Assessments\Aldicarb\Scenario2\Orange_Juice_10_Modified 2 Perc Grapefruit Imports.rdf

 13 6 C:\Users\IEncarna\Dietary Assessments\Aldicarb\Scenario2\Pecan_FTD_13.rdf

 14 6 C:\Users\IEncarna\Dietary Assessments\Aldicarb\Scenario2\Aldicarb_SWCC_pH7_MN 

Sugarbeets_12.rdf

 15 6 C:\Users\IEncarna\Dietary Assessments\Aldicarb\Scenario2\Potato_wPeel_Uncooked 

Baked_14_Imports.rdf

 EPA Crop Commodity Name Def Res Adj.Factors RDLComment

 Code Grp (ppm) #1 #2 Pntr

---------- ---- ------------------------------- ---------- ------ ------ --- -------

0103296000 1C Potato, chips 0.000437 0.620 1.000 

0103297000 1C Potato, dry (granules/ flakes) 0.000437 6.500 1.000 

0103297001 1C Potato, dry (granules/ flakes)-b 0.000437 6.500 1.000 

0103298000 1C Potato, flour 0.000437 6.500 1.000 

0103298001 1C Potato, flour-babyfood 0.000437 6.500 1.000 

0103299000 1C Potato, tuber, w/peel

 110-Uncooked; Fresh or N/S; Cook Meth N/S

 1.000000 1.000 1.000 1 

 210-Cooked; Fresh or N/S; Cook Meth N/S

 1.000000 1.000 1.000 1 

 211-Cooked; Fresh or N/S; Baked

 1.000000 1.000 1.000 1 

 212-Cooked; Fresh or N/S; Boiled

 1.000000 0.500 1.000 1 

 213-Cooked; Fresh or N/S; Fried

 1.000000 0.620 1.000 1 

0103299001 1C Potato, tuber, w/peel-babyfood 1.000000 1.000 1.000 1 

0103300000 1C Potato, tuber, w/o peel

 110-Uncooked; Fresh or N/S; Cook Meth N/S
Aldicarb Dietary Exposure and Risk Assessment DP Number: D430197

Page 28 of 34

 1.000000 1.000 1.000 1 

 210-Cooked; Fresh or N/S; Cook Meth N/S

 1.000000 1.000 1.000 1 

 211-Cooked; Fresh or N/S; Baked

 1.000000 1.000 1.000 1 

 212-Cooked; Fresh or N/S; Boiled

 1.000000 0.500 1.000 1 

 213-Cooked; Fresh or N/S; Fried

 1.000000 0.620 1.000 1 

 221-Cooked; Frozen; Baked 1.000000 1.000 1.000 2 

223-Cooked; Frozen; Fried 1.000000 0.620 1.000 1 

 232-Cooked; Dried; Boiled 1.000000 0.500 1.000 1 

233-Cooked; Dried; Fried 1.000000 0.620 1.000 1 

240-Cooked; Canned; Cook Meth N/S

 1.000000 0.500 1.000 15 

 242-Cooked; Canned; Boiled 1.000000 0.500 1.000 15 

252-Cooked; Cured etc; Boiled 1.000000 0.500 1.000 1 

0103300001 1C Potato, tuber, w/o peel-babyfood

 240-Cooked; Canned; Cook Meth N/S

 1.000000 0.500 1.000 1 

0103366000 1CD Sweet potato

 210-Cooked; Fresh or N/S; Cook Meth N/S

 1.000000 1.000 1.000 3 

 211-Cooked; Fresh or N/S; Baked

 1.000000 1.000 1.000 3 

 212-Cooked; Fresh or N/S; Boiled

 1.000000 0.500 1.000 3 

 213-Cooked; Fresh or N/S; Fried

 1.000000 0.620 1.000 3 

 215-Cooked; Fresh or N/S; Boiled/baked

 1.000000 1.000 1.000 3 

 240-Cooked; Canned; Cook Meth N/S

 1.000000 0.500 1.000 3 

 242-Cooked; Canned; Boiled 1.000000 0.500 1.000 3 

0103366001 1CD Sweet potato-babyfood

 211-Cooked; Fresh or N/S; Baked

 1.000000 1.000 1.000 4 

 240-Cooked; Canned; Cook Meth N/S

 1.000000 0.500 1.000 4 

0600347000 6 Soybean, seed 0.000214 1.000 1.000 

0600349000 6 Soybean, soy milk 0.000214 1.000 1.000 

0600349001 6 Soybean, soy milk-babyfood or in 0.000214 1.000 1.000 

0600350000 6 Soybean, oil 0.000214 0.300 1.000 

0600350001 6 Soybean, oil-babyfood 0.000214 0.300 1.000 

0603030000 6C Bean, black, seed 0.000214 0.050 1.000 

0603032000 6C Bean, broad, seed 0.000214 0.050 1.000 

0603034000 6C Bean, cowpea, seed

 232-Cooked; Dried; Boiled 0.000214 0.050 1.000 

0603035000 6C Bean, great northern, seed 0.000214 0.050 1.000 

0603036000 6C Bean, kidney, seed 0.000214 0.050 1.000 

0603038000 6C Bean, lima, seed 0.000214 0.050 1.000 

0603039000 6C Bean, mung, seed 0.000214 0.050 1.000 

0603040000 6C Bean, navy, seed 0.000214 0.050 1.000 

0603041000 6C Bean, pink, seed 0.000214 0.050 1.000 

0603042000 6C Bean, pinto, seed 0.000214 0.050 1.000 

0603098000 6C Chickpea, seed 0.000214 0.050 1.000 

0603098001 6C Chickpea, seed-babyfood 0.000214 0.050 1.000 

0603099000 6C Chickpea, flour 0.000214 0.050 1.000 

0603182000 6C Guar, seed 0.000214 0.050 1.000 

0603182001 6C Guar, seed-babyfood 0.000214 0.050 1.000 

0603348000 6C Soybean, flour 0.000214 1.000 1.000 

0603348001 6C Soybean, flour-babyfood 0.000214 1.000 1.000 

1001240000 10A Orange 1.000000 1.000 1.000 5 

1001241000 10A Orange, juice 1.000000 1.000 1.000 6 

1001241001 10A Orange, juice-babyfood 1.000000 1.000 1.000 6 

1001242000 10A Orange, peel 1.000000 1.000 1.000 5 

1002199000 10B Lemon 1.000000 1.000 1.000 7 
Aldicarb Dietary Exposure and Risk Assessment DP Number: D430197

Page 29 of 34

1002200000 10B Lemon, juice 1.000000 1.000 1.000 8 

1002200001 10B Lemon, juice-babyfood 1.000000 1.000 1.000 8 

1002201000 10B Lemon, peel 1.000000 1.000 1.000 7 

1002206000 10B Lime 1.000000 1.000 1.000 9 

1002207000 10B Lime, juice 1.000000 1.000 1.000 10 

1002207001 10B Lime, juice-babyfood 1.000000 1.000 1.000 10 

1003180000 10C Grapefruit 1.000000 1.000 1.000 11 

1003181000 10C Grapefruit, juice 1.000000 1.000 1.000 12 

1400269000 14 Pecan 1.000000 1.000 1.000 13 

1500344000 15 Sorghum, grain 0.200000 1.000 1.000 

1500345000 15 Sorghum, syrup 0.200000 1.000 1.000 

2003128000 20C Cottonseed, oil 0.015900 0.100 1.000 

2003128001 20C Cottonseed, oil-babyfood 0.015900 0.100 1.000 

8601000000 86A Water, direct, all sources 1.000000 1.000 1.000 14 

8602000000 86B Water, indirect, all sources 1.000000 1.000 1.000 14 

9500115000 O Coffee, roasted bean 0.008550 1.000 1.000 

9500116000 O Coffee, instant 0.008550 1.000 1.000 

9500263000 O Peanut 0.002115 1.000 1.000 

B) Result files

Food (Refined Potato Imports) and Drinking Water (Sugar beets)

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for ALDICARB ACUTE DIETARY ASSESSMENT

 NHANES 2003-2008 2-Day

Residue file: Aldicarb Acute_Food Water SugarBeet_Refined_PotatoImports.r08

Adjustment factor #2 NOT used.

Analysis Date: 03-23-2016/17:48:49 Residue file dated: 02-18-2016/10:43:52

RAC/FF intake reported by eating occasion

Reversal analysis used with half life = 2 hr(s)

MC iterations = 1000; MC list in residue file; MC seed = 155; RNG = MS VB

MC residues held constant for each RAC/FF intake on same day/iteration

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.000240 88.88 0.001356 502.11 0.004607 1706.15 

All Infants:

 0.000353 130.79 0.002603 964.03 0.007723 2860.41 

Children 1-2:

 0.000348 129.05 0.002022 748.86 0.006976 2583.69 

Children 3-5:

 0.000304 112.76 0.001780 659.41 0.005750 2129.81 

Children 6-12:

 0.000214 79.30 0.001270 470.25 0.004220 1562.94 

Youth 13-19:

 0.000171 63.35 0.001051 389.20 0.003664 1356.94 

Adults 20-49:

 0.000243 90.10 0.001373 508.49 0.004672 1730.31 

Adults 50-99:

 0.000247 91.55 0.001299 481.03 0.004155 1538.98 

Female 13-49:

 0.000239 88.39 0.001364 505.09 0.004677 1732.13 

Food Only (Refined Potato Imports)
Aldicarb Dietary Exposure and Risk Assessment DP Number: D430197

Page 30 of 34

Result File

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for ALDICARB ACUTE DIETARY ASSESSMENT

 NHANES 2003-2008 2-Day

Residue file: Aldicarb Acute_Food Only_Refined_PotatoImports.r08

Adjustment factor #2 NOT used.

Analysis Date: 03-24-2016/09:46:53 Residue file dated: 02-18-2016/10:46:19

RAC/FF intake reported by eating occasion

Reversal analysis used with half life = 2 hr(s)

MC iterations = 1000; MC list in residue file; MC seed = 155; RNG = MS VB

MC residues held constant for each RAC/FF intake on same day/iteration

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.000006 2.15 0.000024 8.73 0.000067 24.99 

All Infants:

 0.000023 8.46 0.000043 16.05 0.000089 33.01 

Children 1-2:

 0.000012 4.62 0.000071 26.31 0.000177 65.47 

Children 3-5:

 0.000010 3.63 0.000053 19.70 0.000133 49.42 

Children 6-12:

 0.000005 2.01 0.000032 11.73 0.000076 28.08 

Youth 13-19:

 0.000003 1.28 0.000022 7.98 0.000050 18.48 

Adults 20-49:

 0.000004 1.64 0.000020 7.24 0.000044 16.41 

Adults 50-99:

 0.000007 2.76 0.000022 8.05 0.000049 18.14 

Female 13-49:

 0.000004 1.59 0.000020 7.24 0.000046 16.89 

CEC Analysis for Food Only (Children 1-2)

US EPA

DEEM-FCID Acute Critical Exposure Contribution Analysis (Ver. 3.18, 03-08-d)

NHANES 2003-2008 2-Day

Residue file = C:\Users\IEncarna\Dietary Assessments\Aldicarb\DEEM Files\Aldicarb 

Acute_Food Only_Refined_PotatoImports.r08

Acute report = C:\Users\IEncarna\Dietary Assessments\Aldicarb\DEEM Files\Aldicarb_Food 

Only_24May2016.AC8

Date and time of analysis: 03-24-2016 09:33:19

Food and foodform consumption evaluated by eating occasion.

Adjustment factor #2 not used.

Minimum exposure contribution = 5%

MC Iterations = 1000 Seed = 155 RNG = MS VB

CEC records generated for first 812 iterations.

Exposures divided by body weight

Children 1-2

Low percentile for CEC records: 99.9 Exposure (mg/day) = 0.000177

High percentile for CEC records: 100 Exposure (mg/day) = 0.001026

Number of actual records in this interval: 2582

Critical foods with foodforms for this population (as derived from these records):

Only foods/foodforms with percent contribution >= 5 are reported.

 N=number of appearances in all records (including duplicates)

 %=percent of total exposure for all records (including duplicates)
Aldicarb Dietary Exposure and Risk Assessment DP Number: D430197

Page 31 of 34

Food FF N Percent Food Name 

---------- --- ----- ------- -------------

1001240000 110 1359 48.97% Orange-Uncooked; Fresh or N/S; Cook Meth N/S

1001241000 110 897 33.08% Orange, juice-Uncooked; Fresh or N/S; Cook Meth N/S

1001241000 120 291 9.20% Orange, juice-Uncooked; Frozen; Cook Meth N/S

Critical foods (without foodforms) for this population (as derived from these records):

Only foods with percent contribution >= 5 are reported.

 N=number of appearances in all records (including duplicates)

 %=percent of total exposure for all records (including duplicates)

Food N Percent Food Name 

---------- ----- ------- -------------

1001240000 1359 48.97% Orange

1001241000 1192 42.29% Orange, juice

Drinking Water Only (Sugar beets)

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for ALDICARB WATER ONLY (SUGARBEET)

 NHANES 2003-2008 2-Day

Residue file: Aldicarb Acute_Water Only SugarBeets.r08

Adjustment factor #2 NOT used.

Analysis Date: 03-23-2016/15:42:45 Residue file dated: 11-12-2015/11:05:07

RAC/FF intake reported by eating occasion

Reversal analysis used with half life = 2 hr(s)

MC iterations = 1000; MC list in residue file; MC seed = 155; RNG = MS VB

MC residues held constant for each RAC/FF intake on same day/iteration

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.000238 88.32 0.001353 501.17 0.004616 1709.59 

All Infants:

 0.000354 131.01 0.002611 967.15 0.007775 2879.72 

Children 1-2:

 0.000343 126.89 0.002007 743.50 0.006928 2566.09 

Children 3-5:

 0.000303 112.15 0.001778 658.44 0.005760 2133.24

Children 6-12:

 0.000212 78.36 0.001263 467.71 0.004206 1557.62 

Youth 13-19:

 0.000171 63.24 0.001051 389.14 0.003696 1368.78 

Adults 20-49:

 0.000242 89.78 0.001371 507.62 0.004677 1732.14 

Adults 50-99:

 0.000245 90.75 0.001293 478.94 0.004186 1550.47 

Female 13-49:

 0.000237 87.94 0.001362 504.43 0.004688 1736.41 

Drinking Water Only (Cotton) 

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for ALDICARB WATER ONLY (SUGARBEET)
Aldicarb Dietary Exposure and Risk Assessment DP Number: D430197

Page 32 of 34

 NHANES 2003-2008 2-Day

Residue file: Aldicarb Acute_Water Only Cotton.r08

Adjustment factor #2 NOT used.

Analysis Date: 03-23-2016/18:09:15 Residue file dated: 11-12-2015/11:13:42

RAC/FF intake reported by eating occasion

Reversal analysis used with half life = 2 hr(s)

MC iterations = 1000; MC list in residue file; MC seed = 155; RNG = MS VB

MC residues held constant for each RAC/FF intake on same day/iteration

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.000016 5.84 0.000125 46.32 0.000492 182.24 

All Infants:

 0.000021 7.82 0.000241 89.13 0.000909 336.58 

Children 1-2:

 0.000023 8.39 0.000186 69.05 0.000743 275.23 

Children 3-5:

 0.000020 7.51 0.000165 61.04 0.000628 232.45 

Children 6-12:

 0.000014 5.12 0.000116 42.99 0.000446 165.07 

Youth 13-19:

 0.000011 4.05 0.000096 35.55 0.000396 146.73 

Adults 20-49:

 0.000016 5.91 0.000127 47.16 0.000501 185.56 

Adults 50-99:

 0.000017 6.19 0.000120 44.47 0.000448 165.94 

Female 13-49:

 0.000016 5.81 0.000126 46.65 0.000498 184.33
Aldicarb Dietary Exposure and Risk Assessment DP Number: D430197

Page 33 of 34

Attachment 4. EDWC at the LOC Considering Exposure through Drinking Water Only

A screening tool was used to provide an estimate of the contribution of pesticide residues in 

drinking water to the dietary risk of the pesticide. Rough estimates of the estimated drinking 

water concentration (EDWC) at the level of concern (LOC) are provided without considering 

contribution from food and residential exposures. Therefore, even if estimated drinking water 

risks are relatively low, aggregate risk may be of concern. The water consumption values were 

obtained using the dietary exposure and risk model, DEEM-FCID Version 4.02, which uses food 

consumption data from the USDA National Health and Nutrition Examination Survey, What We 

Eat in America, conducted from 2005 to 2010; refer to Table A.4.2. In general, the population 

subgroup with higher exposure to residues in drinking water is infants (<1 yr old). The equation 

used to estimate the dietary risk and the results of the screening are presented below.

The lowest EDWC at the level of concern is 1.5 ppb and 0.8 ppb at the 95th and 99.9th percentile 

of exposure, respectively. It is important to note that a distribution of water residues will be used 

for dietary assessment of aldicarb; therefore, the distribution from the modeling a scenario that 

results in a peak concentration similar to those estimated here is likely to result in lower dietary 

risk than that obtained using a point estimate. 

Table A.4.1. Results of the screening of the Dietary Risk Contribution from 

Drinking Water

Assessment Population aPAD 

(mg/kg/day)

EDWC at LOC (ppb)

95th 99.9th

Acute

General 0.00027 5.075188 1.5

All Infants 0.00027 1.47541 0.794118

Females 0.00027 5.13308 2.347826

Equation to estimate the dietary risk:

Table A.4.2. Water consumption (L / kg-bw*day) for Acute Analysis

Population Subgroup Acute

95th 99.9th

General Population 0.0532 0.180

All Infants (< 1yr old) 0.183 0.340

Females (13-49 yrs) 0.0526 0.115

%aPAD, %ssPAD or %cPAD Water =

 Water Consumption, L/kgbw/day EDWC, ppb 

 1000 μg

mg (aPAD, ssPAD or cPAD, mg/kg/day)

x100
Aldicarb Dietary Exposure and Risk Assessment DP Number: D430197

Page 34 of 34

Attachment 5. Commodity Specific Analysis Conducted for Aldicarb.

Table A.5.1. Aldicarb PDP Monitoring Data Used for the Commodity Specific Analysis.

Source of Data Used For Refinement

Maximum Residue / LOD

(ppm)

Potato PDP Data (Import) 0.03796

Sweet Potato PDP Data (Domestic Plus Import) 0.07784

Sweet Potato Baby Food PDP Data (Domestic and Import) 0.0083

Table A.5.2. Commodity Specific Analysis for Aldicarb

Commodity 

(Food)

Age Group Source Exposure %aPAD

Amount Consumed (g) Anticipated Residue 

(ppm) Using FTD or PDP Data

Infant 

(10 kg)

Preschooler 

(15 kg)

Females 

13to49 

(60 kg)

Monitoring 

(PDP)

Residue 

Threshold1

Infant Preschooler

AdultFemale

Potato 71 142 142 0.0380 0.029 100 133 33

Sweet Potato 78 156 156 0.0778 0.026 300 75

Sweet Potato (bf) 78 156 156 0.0083 0.026 24

bf = baby food

1 Residue Threshold = aPAD / Consumption = 0.00027 mg/kg-bw/day / [Amount Consumed (kg/day) / Body Weight (kg)]. 

The residue threshold (i.e. residue level that would result in risk at the level of concern) presented in this table is based on 

preschoolers, the subgroup with highest exposure.