Imazosulfuron Dietary Exposure and R isk Assessment DP Number: 403364
PC Code: 118602

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Page 1 of 12 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION

MEMORANDU M

DATE: January 14, 2013

SUBJECT: Imazosulfuron : Acute and Chronic Aggregate Dietary (Food and Drinking Water) Exposure an d Risk Assessments for the New Uses on t he Melon Crop Subgroup 9A and Tuberous and Corm Vegetables Crop Subgroup 1C

PC Code: 1 18602 DP Barcode: D 403364 Decision No.: 4 64490 Registration No. : 59639

- 154 , 59639

- 166
Petition No.: XXX Regulatory Action: Section 3 Registration Risk Assessment Type: Single Chemical Case No.: NA
T XR No.: NA CAS No.: 122548

- 33

- 8
MRID No.: NA 40 CFR: § 180.651

REVIEWER: Cassi L. Walls , Ph.D. , Senior Biologist
R isk Assessment Branch III / Health Effects Division ( HED; 7509 P )

THROUGH: Thurston Morton , Chemist
Julie Van Alstine

, Environmental Health Scientist Dietary Exposure Science Adviso ry Council (DESAC)/HED (7509P)

TO: Sheila Healy

, Risk Assessor
Risk Assessment Branch III /HED (7509P)

Executive Summary

Acute and chronic aggregate dietary (food and drinking water) exposure and risk assessments were conducted for the herbicide, imazo sulfuron, using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM

- FCID)
Version 3.16

. This software uses 2003

- 2008 food consumption data from the U.S. Department of Agriculture’s (USDA’s) National Health and Nutr ition Examination Survey, What We Eat in America, (NHANES/WWEIA). The analyses were conducted in support of a human health risk assessment for the proposed Section 3 uses on t he Melon Crop Subgroup 9A and Tuberous and Corm Vegetables Crop Subgroup 1C.
Im azosulfuron is currently registered for use on tomatoes, peppers, rice, and turf grassImazosulfuron Dietary Exposure and R isk Assessment DP Number: 403364
PC Code: 118602

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Page 2 of 12 and ornamentals. This memorandum was reviewed by two peer reviewers of the DESAC, per DESAC SOP 2012.1.

Acute Dietary Exposure Results and Characterization

An u nrefin ed dietary assessment was conducted assuming that 100% of crops with the requested uses of imazosulfuron are treated and that all treated crops contain residues at
tolerance level. In addition, default processing factors were assumed for the requested

cro p uses

. Potential residues in drinking water were included in the analyses based on

s urface water results from the Tier I Rice M odel as these val ues were higher than the ground water estimates from the Screening Concentration in Ground Water ( SCI

- GROW )
mod el ( D 362654 Faruque Khan

, 13

- MAY

- 2010 ). Thus

, the results obtained from the present analyses may be considered highly conservative. N o population subgroups
exceed HED’s level of concern at the 95 th percentile of exposure for food and drinking
water. T he U

. S

. population occupied < 1 .0 % of the acute population

- a djusted d ose ( a PA D) , while the most highly exposed population subgroup, all infants (< 1 year old)

, occupied 1.2 % of the a PA D

.

Chronic Dietary Exposure Results and Characterization

An unrefined chronic dietary assessment was conducted assuming that 100% of crops with the requested uses of imazosulfuron are treated and that all treated crops contain
residues at tolerance l evel. In addition, default proc essing factors were assumed for the requeste d crop uses. Potential residues in drinking water were included in the analyses
based on surface water results from the Tier I Rice M odel as these values were higher than the groundwater estimates from the SCI

- GROW model

. N o population subgroups
exceed H ED’s level of concern for dietary exposure from food and drinking water : the
U

. S

. population occupied < 1 % of the chronic population

- a djusted d ose (c PA D), while the most highly exposed population subgroup, all infants (< 1 year old ), occupied 2.0 % of
the c PA D.

Cancer Dietary Exposure Results and Characterization

A determination of cancer risk w as not performed with DEEM

- FCID as part of the present assessment, since this chemical was classified as “Not likely to be Carcinogenic
to Humans” based on negat ive genotoxicity and carcinogenicity in long term cancer
studies in rats and mice. Therefore, a cancer dietary assessment for imazosulfuron is not required.

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesti cide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). This dose i s referred to as the population

- adjuste d dose (PAD). The PAD is equivalent to point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.Imazosulfuron Dietary Exposure and R isk Assessment DP Number: 403364
PC Code: 118602

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Page 3 of 12 For acute and non

- cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 21

- JUN

- 2000,
web link: http://www.epa.gov/fedrgstr/EPA

- PEST/2000/July/Day

- 12/6061.pdf ; or see SOP 99.6 (20

- AUG

- 1999).

The most recent dietary risk assessment for imazosulfuron was con ducted by C. Walls (06/28/10, D 367020 ).

II. Residue Information

Imazosulfuron is a sulfonylurea herbicide registered by Valent U.S.A Corporation for
control of broad

- leaf weeds and sedges

. T he mode of action of imazosulfuron is
inhibition of the enzyme acetolactate synthase

. Tolerances are requested for the residue
of imazosulfuron ( 2

- chloro

- N

- [[(4,6

- dimethoxy

- 2

- pyrimidinyl)amino]carbonyl]imidazo[1,2

- α ]pyridine

- 3

- sulfonamide )
in/on melons (Crop Subgroup 9A) and tuberous and corm v egetables ( Crop Subgroup
1C ) both at 0.02 ppm. These toleranc es were requested by Valent, as well as, recommended by HED.

The HED Residues of Concern Knowledge

- based Subcommittee (ROCKS) reviewed and
discussed potato, rice , tomato, rotational crops, and livestock studies for the
imazosulfuron , as well as toxicologi cal and environmental fate data, for determination of the residues of concern ( 06/19/10 )

. HED has determined that the residue of concern in crop commodities for tolerance enforcement assessment is imazosulfuron, whereas, the
residue of concern for risk as sessment is the sum of imazosulfuron and its metabolite

, 4,6

- dimethoxy

- 2

- ureidopyrimidine ( UDPM ) (D377141, Edward Scollon, 06/01/10 ). Residue information for the proposed food commodities included in the present analyses
was taken from the imazosulfuron r esidue chemistry memo (D 402303

, A. Acierto

, 09/05/12).

For both the acute and chronic dietary analyse s, the recommended tolerance s and default processing factors were used for each food commodity residue level. The acute and
chronic assessment s also assume that 100% of the crops are treated. Table 1 summarizes
the imazosulfuron residue levels for the proposed crops used in the acute and chronic dietary assessments.

Table 1. Summary of Imazosulfuron Residue Levels Used in Acute and Chronic Analyse s. Matrix Residue Level [Acute and Chronic ] (ppm) * Default Processing Factor s

Proposed Crops Tuberous and Corm Vegetables Crop Subgroup 1C 0.04 --

Melons Crop Subgroup 9A 0.04 Potatoes, dried = 6.5

Currently Registered CropsImazosulfuron Dietary Exposure and R isk Assessment DP Number: 403364
PC Code: 118602

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Page 4 of 12 Table 1. Summary of Imazosulfuron Residue Levels Used in Acute and Chronic Analyse s. Matrix Residue Level [Acute and Chronic ] (ppm) * Default Processing Factor s

Pepper 0.04

-- Rice, gr ain 0.04

-- Tomato

0.04 Tomato paste = 5.4 ; T omato puree = 3.3 ; Tomato, dried = 14.3; Tomato juice = 1.5
* The residue level of 0.04 ppm used in the assessment s is the sum of the imazosulfuron proposed tolerance (0.02ppm) and its UDPM metabolite (0.02 ppm)

III. Percent Crop Treated Information

For both the acute and chronic assessments, 100% was used for the percent crop treated
values.

IV

. Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by the
Env ironmental Fate and Effects Division (EFED) ( D 362654

, F. Khan

, 05/13/10 ) ( D 402305, F. Khan

, 08/16/12 )

. The drinking water residues modeled for the proposed uses on melons and tuberous vegetables are lower than the residues previously modeled
for the rice use. Therefore, EWDCs resulting from the rice use was used in the current dietary assessments. Water residues bold ed in Table 2 were directly incorporated in the
DEEM

- FCID into the food categories “water, direct, all sources” and “water, indirect, all

so urces.”

Table 2. Tier I EDWCs for Imazosulfuron A pplications

Drinking Water
Source Model Use rate (lbs ai/A/year) Acute ( μg/L ) Chronic ( μg/L )

Surface water Tier I Rice Model 0.3 278.9 278.9

Groundwater SCI

- GROW 1.34 4.8 4.8

Surface Water

. T he highest estimated drinking water concen tration (EDWC) for
imazosulfuron resulted from the Tier I Rice M odel

. This recommended E DWC of 278.9 μg/L is based on aerial spray application of 0.3 lbs. a.i./A per year for rice.

Groundwater . In lieu of sufficient groundwater m onitoring data for imazosulfuron , the Tier 1 groundwater screening model SCI

- GROW was used to estimate concent ration of
imazosulfuron in groundwater sources. Turf grass applications with an annual use rate of
1.34 lbs ai/A/year w as used in the modeling and result e d in a groundwater EDWC of 4.8 μg/L.

Because the acute and chronic surface water estimates were high e r than the ground water estim ates, the present analyses use d of the surface water EWDC of 0.2789 ppm

.Imazosulfuron Dietary Exposure and R isk Assessment DP Number: 403364
PC Code: 118602

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Page 5 of 12 V. DEEM

- FCID Program and Consumption Information

Imazosulfuron acute and chronic dietary exposure assessments were conducted using the
DEEM

- FCID, Versio n 3.16, which incorporates consumption data from USDA’s NHANES/WWEIA. This dietary survey was conducted from 2003 to 2008. The data are based on the reported consumption of more than 20,000 individuals over two non

consecutive survey days. Foods “as con sumed” (e.g., apple pie) are linked to EPA

defined food commodities (e.g. apples, peeled fruit

- cooked; fresh or N/S; baked; or
wheat flour

- cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire US population and within population subgroups. Based on analysis of the 1994

- 96, 98 CSFII consumption data, which took into account dietary patterns of survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19, adults 20

- 4 9, females 13

- 49, and adults 50

- 99 years old.

For chronic dietary exposure assessment s , an estimate of the residue level in each food or
food

- form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food fo rm to produce a residue intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposur e. Exposure is expressed in mg/kg body weight/ day and as a percent of the cRfD . This procedure is performed for each population subgroup.

For acute exposure assessments, individual one

- day food consumption data are used on
an individual

- by

- individual ba sis. The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue valu es and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and a per

capita (i.e., those who repo rted eating the relevant commodities as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk are reported for all tiers of analysis.

V I

. Toxicological Information

All information specific to th e t oxicity charac teristics of imazosulfuron are presented in
the most recent risk assessment supporting the turf grass and ornamental uses ( D 348001

, S. Healy et al.

, 03/13/09 ). For the acute and c hronic exposure scenario s , the standard 100 fold UF was applied to account f or inter

- species extrapolation and intra

- species variation

. The FQPA Safety Factor can be reduced to 1X because there is an adequate toxicity database for imazosulfuron; there is no evidence of susceptibility following in utero and/or postnatal exposure i n the developmental toxicity studies in rats or rabbits, or in the
2

- generation rat reproduction study and there are no residual uncertainties concerningImazosulfuron Dietary Exposure and R isk Assessment DP Number: 403364
PC Code: 118602

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Page 6 of 12 pre

- and postnatal toxicity and no neurotoxicity concerns. As previously noted, a cancer risk evaluat ion is not included in this assessment. To provide an overview of the toxicological profile, a summary of the doses and endpoints selected for the re le vant dietary exposure scenarios is provided in Table 3

.

Table 3

. Summary of Toxicological Doses and Endpoints for Imazosulfuron for Use in Dietary Exposure Risk Assessments Exposure/ Scenario Point of Departure Uncertainty/FQPA Safety Factors RfD, PAD, Level of Concern Study and Toxicological Effects
Acute Dietary (All Populations) NOAEL =
400 mg/kg/d ay UF A = 10x
UF H = 10x FQPA SF = 1x aRfD = 4 mg/kg/day

aPAD = 4 mg/kg/day Acute neurotoxicity screening battery (MRID 47305319). LOAEL = 2000 mg/kg/day based on based on the following clinical signs: abnormal gait, decreased activity, piloerection
and upward curvature of the spine; and incidents of irregular breathing, reduced righting reflex, tremors, decreased visual placement response in males and increased response to
sound in one female.
Chronic Dietary (All Populations) NOAEL =
75 mg/kg/day UF A = 10x
UF H = 10x FQPA SF= 1x cRfD = 0.75 mg/kg/day

cPAD = 0.75 mg/kg/day Chronic toxicity (dog; MRID 47305305) LOAEL = 150 mg/kg/day based

on based on increased relative liver weights, increased serum alkaline phosphatase activity and moderate thyroid
h ypertrophy (males only at
mid

- dose
Cancer Classification: “ Not likely to be Carcinogenic to Humans ” based on the absence of significant tumor increases in two adequate rodent carcinogenicity studies (MRID 47305307, mouse; 47305306, rat). Point of Depar ture (POD) = A data point or an estimated point that is derived from observed dose

- response data and used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A = extrapolation from animal to human (intraspecies). UF H = potential variation in sensitivity among members of the human population (interspecies). FQPA SF = FQP A S afety Factor. PAD = population

- adjusted dose (a = acute, c = chronic). RfD = reference dose.

VI I

. Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk
exceeds 100% of the PAD. The DEEM

- FCID ana lyses estimat e the dietary exposure of
the U

. S

. population and various population subgroups. The results reported in Table 4
are for the general U.S. Population, all infants (<1 year old), children 1

- 2, children 3

- 5,
children 6

- 12, youth 13

- 19, females 13

- 49, adults 20

- 49, and adults 50

- 99 years.

Results of Acute and Chronic Dietary (Food and Drinking Water) Exposure Analysis

Acute dietary risk a nalyses were conducted with the DEEM

- FCID model to form a conservative evaluation of exposure for imazosulfu ron

. At the 95 th percentile ofImazosulfuron Dietary Exposure and R isk Assessment DP Number: 403364
PC Code: 118602

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Page 7 of 12 exposure, a ll acute analys e s yielded risk estimates well below the 100% of the aPA D threshold level of concern for each population subgroup. For food and drinking water,
the U

. S

. Population subgroup acute aggregate di eta ry risk was calcul ated at <1 % of the
aPAD wi th an exposure level of 0.015 mg/kg/day. For the subgroup with the highest calculated exposure, all infants

, acute aggregate dietary risk occupied 1.2 % of the aPA D with an exposure of 0.0 48 mg/kg/day. An overview summarizing the results of the acute dietary assessments with the population subgroup having the highest exposure noted in bold is presented in Table 4

.

C hronic dietary risk a nalys e s were conducted with the DEEM

- FCIDTM model to form a
conservative evaluation of exposure for imazosulfuron

. All chronic analys e s yield ed risk
estimates well below the 100% of the c PA D threshold level of concern for each population subgroup. For food and drinking water, the U

. S

. P opulation subgroup chronic aggregate dietary risk w as calculated at <1 .0 % of the cPA D with an exposure level of
0.0060 mg/kg/day. For the subgroup with the highest calculated exposure, all infants

, chronic aggregate dietary risk occupied 2.0 % of the c PA D with an exposure of 0. 02 0 mg/kg/day

. An overview summarizing the results of the chronic dietary assessment with the population subgroup h aving the highest exposure noted in bold is presented in Table
4

.

Table 4

. Summary of Dietary (Food and Drinking Wat er) Exposure and Risk for Imazosulfuron

Population Subgroup Acute Dietary (95th Percentile) Chronic Dietary Cancer

Dietary Exposure (mg/kg/day) % aPAD* Dietary Exposure (mg/kg/day) % cPAD* Dietary Exposure (mg/kg/day) Risk

General U.S. Population 0.015 36 1 < 1 0.00595 7 < 1

N/A N/A All Infants (<1 year old) 0.0477 50 1.2 0.0152 10 2.0

Children 1

- 2 years old 0.023786 < 1 0.008712 1.2

Children 3

- 5 years old 0.019404 < 1 0.007367 1.0

Children 6

- 12 years old 0.014765 < 1 0.005292 < 1

Youth 13

- 19 ye ars old 0.012823 < 1 0.004362 < 1

Adults 20

- 49 years old 0.015069 < 1 0.005927 < 1

Adults 50

- 99 years old 0.013496 < 1 0.005848 < 1

Females 13

- 49 years old 0.015336 < 1 0.005898 < 1 * % PADs are reported to 2 significant figures. The values f or the highest population for each type of risk
assessment are bolded.

VI I I. Characterization of Inputs/Outputs

The acute and chronic dietary assessment s conducted with DEEM

- FCID for
imazosulfuron are unrefined analyse s. In addition to tolerance

- level r esidues, default processing factors

, and 100% crop treated assumptions, i t utilized conse rvative EDW Cs derived through EFED modeling which are unlikely to underestimate the concentration of
imazosulfuron in drinking water

. The present DEEM

- FCID analysis a ssumes that all drinking water will contain imazosulfuron at the highest acute E DW C levels modeled by
EFED for ground water or surface water

. For these reasons

, it can be concluded that theImazosulfuron Dietary Exposure and R isk Assessment DP Number: 403364
PC Code: 118602

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Page 8 of 12 DEEM

- FCID analysi s do es not underestimate risk from acute and chro nic exposure to imazosulfuron for the general U

. S

. population and all its subgroups.

IX

. Conclusions

The conservative acute and ch r onic dietary risk assessment s conducted with DEEM

FCID indicate that exposure s to imazosulfuron are below HED’s level of co ncern. The

acute dietary risk to imazosulfuron is estimated to be <1.0 % of the aPA D for the general
U

. S

. population and 1.2 % of the aPAD f or the most highly exposed population subgroup

, all infants (<1year old)

. The chronic dietary risk to imazosulfuron is estimated to be <1.0% of the cPAD for the general U.S. population and 2.0 % of the cPAD for the most highly exposed population subgroup, all infants (<1year old)

. Therefore, HED does not have any concerns for the propos ed new tolerances of imazosulfuron

.

X. List of Attachments

1. Attachment 1: Acute and Chronic Dietary Exposure (food + water) Input File.
2. Attachment 2: Acute Dietary Exposure (food + water) Results File.
3

. Attachment 3 : Chronic Dietary Exposure (food + water) Results File.Imazosulfuron Dietary Exposure and R isk Assessment DP Number: 403364
PC Code: 118602

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Page 9 of 12 ATTACHMENT 1

Filename: C: \ Documents and Settings \ cwalls \ My

Documents \ Cassi \ HED \ Imazasulfuron \ 2013 \ IMAZASULFURON FOOD AND WATER 010913.R08 Chemical: Imazasulfuron RfD(Chronic): .75 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): 4 mg/kg bw/day NO EL(Acute): 0 mg/kg bw/day Date created/last modified: 01

- 10

- 2013/11:23:52 Program ver. 3.16, 03

- 08

- d

--------------------------------------------------- ------------------------------ EPA Crop Def Res Adj. Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- -- -------- ------ ------ ----- 0103015000 1CD Arrowroot, flour 0.040000 1.000 1.000
010301 5001 1CD Arrowroot, flour

- babyfood 0.040000 1.000 1.000 0103017000 1CD Artichoke, Jerusalem 0.040000 1.000 1.000

0103082000 1CD Cassava 0.040000 1.000 1.000
0103082001 1CD Cassava

- babyfoo d 0.040000 1.000 1.000 0103139000 1CD Dasheen, corm 0.040000 1.000 1.000 0103166000 1CD Ginger 0.040000 1.000 1.000 0103166001 1CD Ginger

- babyfood 0.040 000 1.000 1.000 0103167000 1CD Ginger, dried 0.040000 1.000 1.000 0103296000 1C Potato, chips 0.040000 1.000 1.000 0103297000 1C Potato, dry (granules/ flakes) 0.040000 6.500 1.000
0103 297001 1C Potato, dry (granules/ flakes)

- b 0.040000 6.500 1.000 0103298000 1C Potato, flour 0.040000 6.500 1.000 0103298001 1C Potato, flour

- babyfood 0.040000 6.500 1.000 0103299000 1C Potato, tuber , w/peel 0.040000 1.000 1.000 0103299001 1C Potato, tuber, w/peel

- babyfood 0.040000 1.000 1.000 0103300000 1C Potato, tuber, w/o peel 0.040000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel

- babyfood 0.0 40000 1.000 1.000 0103366000 1CD Sweet potato 0.040000 1.000 1.000 0103366001 1CD Sweet potato

- babyfood 0.040000 1.000 1.000 0103371000 1CD Tanier, corm 0.040000 1.000 1.000

01 03387000 1CD Turmeric 0.040000 1.000 1.000 0103406000 1CD Yam, true 0.040000 1.000 1.000
0103407000 1CD Yam bean 0.040000 1.000 1.000
0801375000 8A Tomato 0.040000 1.000 1.000
0801375001 8A Tomato

- babyfood 0.040000 1.000 1.000 0801376000 8A Tomato, paste 0.040000 5.400 1.000 0801376001 8A Tomato, paste

- babyfood 0 .040000 5.400 1.000 0801377000 8A Tomato, puree 0.040000 3.300 1.000 0801377001 8A Tomato, puree

- babyfood 0.040000 3.300 1.000 0801378000 8A Tomato, dried 0.040000 14.300 1.000 0801378001 8A Tomato, dried

- babyfood 0.040000 14.300 1.000 0801379000 8A Tomato, juice 0.040000 1.500 1.000 0802270000 8B Pepper, bell 0.040000 1.000 1.000 0802270001 8B Pepper, b ell

- babyfood 0.040000 1.000 1.000 0802271000 8B Pepper, bell, dried 0.040000 1.000 1.000 0802271001 8B Pepper, bell, dried

- babyfood 0.040000 1.000 1.000 0802272000 8BC Pepper, nonbell 0.040000 1.000 1.000 0802272001 8BC Pepper, nonbell

- babyfood 0.040000 1.000 1.000 0802273000 8BC Pepper, nonbell, dried 0.040000 1.000 1.000 0901075000 9A Cantaloupe 0.040000 1.000 1.000 0901187000 9A Honeydew melon 0.040000 1.000 1.000
0901399000 9A Watermelon 0.040000 1.000 1.000 0901400000 9A Watermelon, juice 0.040000 1.000 1.000 1500323000 15 Rice, w hite 0.040000 1.000 1.000 1500323001 15 Rice, white

- babyfood 0.040000 1.000 1.000 1500324000 15 Rice, brown 0.040000 1.000 1.000 1500324001 15 Rice, brown

- babyfood 0.040000 1.000 1.000 1500325000 15 Rice, flour 0.040000 1.000 1.000 1500325001 15 Rice, flour

- babyfood 0.040000 1.000 1.000 1500326000 15 Rice, bran 0.040000 1.000 1.00 0 1500326001 15 Rice, bran

- babyfood 0.040000 1.000 1.000Imazosulfuron Dietary Exposure and R isk Assessment DP Number: 403364
PC Code: 118602

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Page 10 of 12 8601000000 86A Water, direct, all sources 0.278900 1.000 1.000 8602000000 86B Water, indirect, all sources 0.278900 1.000 1.000Imazosulfuron Dietary Exposure and R isk Assessment DP Number: 403364
PC Code: 118602

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Page 11 of 12 **ATTACHMENT 2** 

U.S. EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for IMAZASULFURON NHANES 2003

- 2008 2

- Day Residue file: IMAZASULFURON FOOD AND WATER 010913.R08 Adjustment factor #2 NOT used. Analysis Date: 0 1

- 16

- 2013/16:29:34 Residue file dated: 01

- 16

- 2013/16:27:52 RAC/FF intake summed over 24 hours

Run Comment: ""

===============================================================================

Summary calculations

-- per capita:

95th Per centile 99th Percentile 99.9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- -------- Total US Population:
0.01 5361 0.38 0.025228 0.63 0.047697 1.19
All Infants:
0.047750 1.19 0.064504 1.61 0.095203 2.38
Female 13

- 50:
0.015297 0.38 0.022484 0.56 0.031983 0.80
Children 1

- 2:
0.023786 0.59 0.035592 0.89 0.086784 2.17 Children 3

- 5:
0.019404 0.49 0.029755 0.74 0.047425 1.19 Children 6

- 12:
0.014765 0.37 0.023801 0.60 0.036685 0.92
Youth 13

- 19:
0.012824 0.32 0.021082 0.53 0.031881 0.80
Adults 20

- 49:
0.015069 0.38 0.022396 0.56 0.032521 0.81
Adults 50

- 99:
0.013496 0.34 0.020598 0.51 0.031943 0.80
Female 13

- 49:
0.015336 0.38 0.022483 0.56 0.031664 0.79Imazosulfuron Dietary Exposure and R isk Assessment DP Number: 403364
PC Code: 118602

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Page 12 of 12 ATTACHMENT 3

U.S. EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID Chro nic analysis for IMAZASULFURON NHANES 2003

- 2008 2

- day
Residue file name: C: \ Documents and Settings \ cwalls \ My

Documents \ Cassi \ HED \ Imazasulfuron \ 2013 \ IMAZASULFURON FOOD AND WATER 010913.R08 Adjus tment factor #2 NOT used. Analysis Date 01

- 16

- 2013/16:28:13 Residue file dated: 01

- 16

- 2013/16:27:52 Reference dose (RfD, Chronic) = .75 mg/kg bw/day

===============================================================================
Tot al exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

-------------------------------- --- Population mg/kg Percent of

Subgroup body wt/day Rfd

-------------------------------------- ------------- ---------------- Total US Population 0.005957 0.8% Hispanic 0.005711 0.8%

Non

- Hisp

- White 0.006121 0.8%

Non

- Hisp

- Black 0.004924 0.7%

Non

- Hisp

- Other 0.006869 0.9% Nursing Infants 0.005369 0.7%

Non

- Nursing Infants 0.019605 2.6%
Female 13+ PRE G 0.005613 0.7%
Children 1

- 6 0.007747 1.0% Children 7

- 12 0.005034 0.7%
Male 13

- 19 0.00 4127 0.6%
Female 13

- 19/NP 0.004593 0.6%
Male 20+ 0.005543 0.7% Female 20+/NP 0.006223 0.8%
Seniors 55+ 0.005733 0.8%
All Infants 0.015210 2.0%
Female 13

- 50 0.005904 0.8%
Children 1

- 2 0.008712 1.2% Children 3

- 5 0.007367 1.0% Children 6

- 12 0.005292 0.7%
Youth 13

- 19 0.004362 0.6%
Ad ults 20

- 49 0.005927 0.8%
Adults 50

- 99 0.005848 0.8%
Female 13

- 49 0.005898 0.8%

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