Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 403364

PC Code: 118602

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF CHEMICAL SAFETY AND

 POLLUTION PREVENTION

MEMORANDUM

DATE: January 14, 2013 

SUBJECT: Imazosulfuron: Acute and Chronic Aggregate Dietary (Food and 

Drinking Water) Exposure and Risk Assessments for the New Uses on the 

Melon Crop Subgroup 9A and Tuberous and Corm Vegetables Crop 

Subgroup 1C

PC Code: 118602 DP Barcode: D403364

Decision No.: 464490 Registration No.: 59639-154, 59639-166

Petition No.: XXX Regulatory Action: Section 3 Registration

Risk Assessment Type: Single Chemical Case No.: NA

TXR No.: NA CAS No.: 122548-33-8

MRID No.: NA 40 CFR: §180.651

REVIEWER: Cassi L. Walls, Ph.D., Senior Biologist

Risk Assessment Branch III/Health Effects Division (HED; 7509P)

THROUGH: Thurston Morton, Chemist

Julie Van Alstine, Environmental Health Scientist

Dietary Exposure Science Advisory Council (DESAC)/HED (7509P)

TO: Sheila Healy, Risk Assessor

Risk Assessment Branch III/HED (7509P)

Executive Summary

Acute and chronic aggregate dietary (food and drinking water) exposure and risk 

assessments were conducted for the herbicide, imazosulfuron, using the Dietary Exposure 

Evaluation Model software with the Food Commodity Intake Database (DEEM-FCID) 

Version 3.16. This software uses 2003-2008 food consumption data from the U.S. 

Department of Agriculture’s (USDA’s) National Health and Nutrition Examination 

Survey, What We Eat in America, (NHANES/WWEIA). The analyses were conducted 

in support of a human health risk assessment for the proposed Section 3 uses on the 

Melon Crop Subgroup 9A and Tuberous and Corm Vegetables Crop Subgroup 1C. 

Imazosulfuron is currently registered for use on tomatoes, peppers, rice, and turf grass 
Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 403364

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and ornamentals. This memorandum was reviewed by two peer reviewers of the 

DESAC, per DESAC SOP 2012.1.

Acute Dietary Exposure Results and Characterization

An unrefined dietary assessment was conducted assuming that 100% of crops with the 

requested uses of imazosulfuron are treated and that all treated crops contain residues at 

tolerance level. In addition, default processing factors were assumed for the requested 

crop uses. Potential residues in drinking water were included in the analyses based on 

surface water results from the Tier I Rice Model as these values were higher than the 

groundwater estimates from the Screening Concentration in Ground Water (SCI-GROW)

model (D362654 Faruque Khan, 13-MAY-2010). Thus, the results obtained from the 

present analyses may be considered highly conservative. No population subgroups 

exceed HED’s level of concern at the 95th percentile of exposure for food and drinking 

water. The U.S. population occupied < 1.0% of the acute population-adjusted dose 

(aPAD), while the most highly exposed population subgroup, all infants (< 1 year old),

occupied 1.2% of the aPAD. 

Chronic Dietary Exposure Results and Characterization

An unrefined chronic dietary assessment was conducted assuming that 100% of crops 

with the requested uses of imazosulfuron are treated and that all treated crops contain 

residues at tolerance level. In addition, default processing factors were assumed for the

requested crop uses. Potential residues in drinking water were included in the analyses 

based on surface water results from the Tier I Rice Model as these values were higher 

than the groundwater estimates from the SCI-GROW model. No population subgroups 

exceed HED’s level of concern for dietary exposure from food and drinking water: the 

U.S. population occupied < 1% of the chronic population-adjusted dose (cPAD), while 

the most highly exposed population subgroup, all infants (< 1 year old), occupied 2.0% of 

the cPAD. 

Cancer Dietary Exposure Results and Characterization

A determination of cancer risk was not performed with DEEM-FCID as part of the 

present assessment, since this chemical was classified as “Not likely to be Carcinogenic 

to Humans” based on negative genotoxicity and carcinogenicity in long term cancer 

studies in rats and mice. Therefore, a cancer dietary assessment for imazosulfuron is not 

required.

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For 

acute and chronic assessments, the risk is expressed as a percentage of a maximum 

acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable 

adverse health effects). This dose is referred to as the population-adjusted dose (PAD). 

The PAD is equivalent to point of departure (POD, NOAEL, LOAEL, e.g.) divided by 

the required uncertainty or safety factors.
Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 403364

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For acute and non-cancer chronic exposures, HED is concerned when estimated dietary 

risk exceeds 100% of the PAD. References which discuss the acute and chronic risk 

assessments in more detail are available on the EPA/pesticides web site: “Available 

Information on Assessing Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, 

web link: http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf ; or see 

SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for imazosulfuron was conducted by C. Walls 

(06/28/10, D367020).

II. Residue Information

Imazosulfuron is a sulfonylurea herbicide registered by Valent U.S.A Corporation for 

control of broad-leaf weeds and sedges. The mode of action of imazosulfuron is 

inhibition of the enzyme acetolactate synthase. Tolerances are requested for the residue

of imazosulfuron (2-chloro-N-[[(4,6-dimethoxy-2-

pyrimidinyl)amino]carbonyl]imidazo[1,2-α]pyridine-3-sulfonamide)

in/on melons (Crop Subgroup 9A) and tuberous and corm vegetables (Crop Subgroup 

1C) both at 0.02 ppm. These tolerances were requested by Valent, as well as, 

recommended by HED.

The HED Residues of Concern Knowledge-based Subcommittee (ROCKS) reviewed and 

discussed potato, rice, tomato, rotational crops, and livestock studies for the 

imazosulfuron, as well as toxicological and environmental fate data, for determination of 

the residues of concern (06/19/10). HED has determined that the residue of concern in 

crop commodities for tolerance enforcement assessment is imazosulfuron, whereas, the 

residue of concern for risk assessment is the sum of imazosulfuron and its metabolite,

4,6-dimethoxy-2-ureidopyrimidine (UDPM) (D377141, Edward Scollon, 06/01/10). 

Residue information for the proposed food commodities included in the present analyses 

was taken from the imazosulfuron residue chemistry memo (D402303, A. Acierto, 

09/05/12). 

For both the acute and chronic dietary analyses, the recommended tolerances and default 

processing factors were used for each food commodity residue level. The acute and 

chronic assessments also assume that 100% of the crops are treated. Table 1 summarizes 

the imazosulfuron residue levels for the proposed crops used in the acute and chronic 

dietary assessments. 

Table 1. Summary of Imazosulfuron Residue Levels Used in Acute and Chronic Analyses.

Matrix Residue Level

[Acute and Chronic] (ppm)*

Default Processing Factors

Proposed Crops

Tuberous and Corm Vegetables 

Crop Subgroup 1C 0.04 --

Melons Crop 

Subgroup 9A 0.04 Potatoes, dried = 6.5

Currently Registered Crops
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Table 1. Summary of Imazosulfuron Residue Levels Used in Acute and Chronic Analyses.

Matrix Residue Level

[Acute and Chronic] (ppm)*

Default Processing Factors

Pepper 0.04 --

Rice, grain 0.04 --

Tomato

0.04

Tomato paste = 5.4; 

Tomato puree = 3.3; 

Tomato, dried = 14.3;

Tomato juice = 1.5

* The residue level of 0.04 ppm used in the assessments is the sum of the imazosulfuron proposed tolerance 

(0.02ppm) and its UDPM metabolite (0.02 ppm)

III. Percent Crop Treated Information

For both the acute and chronic assessments, 100% was used for the percent crop treated 

values.

IV. Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by the 

Environmental Fate and Effects Division (EFED) (D362654, F. Khan, 05/13/10)

(D402305, F. Khan, 08/16/12). The drinking water residues modeled for the proposed 

uses on melons and tuberous vegetables are lower than the residues previously modeled 

for the rice use. Therefore, EWDCs resulting from the rice use was used in the current 

dietary assessments. Water residues bolded in Table 2 were directly incorporated in the 

DEEM-FCID into the food categories “water, direct, all sources” and “water, indirect, all 

sources.” 

Table 2. Tier I EDWCs for Imazosulfuron Applications

Drinking Water 

Source 

Model Use rate (lbs 

ai/A/year)

Acute (μg/L) Chronic (μg/L)

Surface water Tier I Rice Model 0.3 278.9 278.9

Groundwater SCI-GROW 1.34 4.8 4.8

Surface Water. The highest estimated drinking water concentration (EDWC) for 

imazosulfuron resulted from the Tier I Rice Model. This recommended EDWC of 278.9

μg/L is based on aerial spray application of 0.3 lbs. a.i./A per year for rice. 

Groundwater. In lieu of sufficient groundwater monitoring data for imazosulfuron, the 

Tier 1 groundwater screening model SCI-GROW was used to estimate concentration of 

imazosulfuron in groundwater sources. Turf grass applications with an annual use rate of 

1.34 lbs ai/A/year was used in the modeling and resulted in a groundwater EDWC of 4.8

μg/L.

Because the acute and chronic surface water estimates were higher than the groundwater 

estimates, the present analyses used of the surface water EWDC of 0.2789 ppm.
Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 403364

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V. DEEM-FCID Program and Consumption Information

Imazosulfuron acute and chronic dietary exposure assessments were conducted using the 

DEEM-FCID, Version 3.16, which incorporates consumption data from USDA’s 

NHANES/WWEIA. This dietary survey was conducted from 2003 to 2008. The data are 

based on the reported consumption of more than 20,000 individuals over two nonconsecutive survey days. Foods “as consumed” (e.g., apple pie) are linked to EPAdefined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or 

wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files 

developed jointly by USDA/ARS and EPA. For chronic exposure assessment, 

consumption data are averaged for the entire US population and within population 

subgroups. Based on analysis of the 1994-96, 98 CSFII consumption data, which took 

into account dietary patterns of survey respondents, HED concluded that it is most 

appropriate to report risk for the following population subgroups: the general U.S. 

population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-

19, adults 20-49, females 13-49, and adults 50-99 years old.

For chronic dietary exposure assessments, an estimate of the residue level in each food or 

food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied 

by the average daily consumption estimate for that food/food form to produce a residue 

intake estimate. The resulting residue intake estimate for each food/food form is summed 

with the residue intake estimates for all other food/food forms on the commodity residue 

list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg 

body weight/day and as a percent of the cRfD. This procedure is performed for each 

population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on 

an individual-by-individual basis. The reported consumption amounts of each food item 

can be multiplied by a residue point estimate and summed to obtain a total daily pesticide 

exposure for a deterministic exposure assessment, or “matched” in multiple random 

pairings with residue values and then summed in a probabilistic assessment. The 

resulting distribution of exposures is expressed as a percentage of the aPAD on both a 

user (i.e., only those who reported eating relevant commodities/food forms) and a percapita (i.e., those who reported eating the relevant commodities as well as those who did 

not) basis. In accordance with HED policy, per capita exposure and risk are reported for 

all tiers of analysis. 

VI. Toxicological Information

All information specific to the toxicity characteristics of imazosulfuron are presented in 

the most recent risk assessment supporting the turf grass and ornamental uses (D348001, 

S. Healy et al., 03/13/09). For the acute and chronic exposure scenarios, the standard 100

fold UF was applied to account for inter-species extrapolation and intra-species variation. 

The FQPA Safety Factor can be reduced to 1X because there is an adequate toxicity 

database for imazosulfuron; there is no evidence of susceptibility following in utero

and/or postnatal exposure in the developmental toxicity studies in rats or rabbits, or in the 

2-generation rat reproduction study and there are no residual uncertainties concerning 
Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 403364

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pre- and postnatal toxicity and no neurotoxicity concerns. As previously noted, a cancer 

risk evaluation is not included in this assessment. To provide an overview of the

toxicological profile, a summary of the doses and endpoints selected for the relevant 

dietary exposure scenarios is provided in Table 3. 

Table 3. Summary of Toxicological Doses and Endpoints for Imazosulfuron for Use in Dietary 

Exposure Risk Assessments

Exposure/

Scenario

Point of 

Departure

Uncertainty/FQPA 

Safety Factors

RfD, PAD, Level 

of Concern 

Study and Toxicological 

Effects

Acute 

Dietary (All 

Populations)

NOAEL = 

400

mg/kg/day

UFA = 10x 

UFH = 10x 

FQPA SF = 1x 

aRfD = 4

mg/kg/day

aPAD = 4

mg/kg/day

Acute neurotoxicity screening 

battery (MRID 47305319).

LOAEL = 2000 mg/kg/day 

based on based on the following 

clinical signs: abnormal gait, 

decreased activity, piloerection 

and upward curvature of the 

spine; and incidents of irregular 

breathing, reduced righting 

reflex, tremors, decreased 

visual placement response in 

males and increased response to 

sound in one female.

Chronic 

Dietary (All 

Populations)

NOAEL = 

75

mg/kg/day

UFA = 10x 

UFH = 10x 

FQPA SF= 1x 

cRfD = 0.75

mg/kg/day

cPAD = 0.75

mg/kg/day

Chronic toxicity (dog; MRID 

47305305)

LOAEL = 150 mg/kg/day based 

on based on increased relative 

liver weights, increased serum 

alkaline phosphatase activity 

and moderate thyroid 

hypertrophy (males only at 

mid-dose

Cancer Classification: “Not likely to be Carcinogenic to Humans” based on the 

absence of significant tumor increases in two adequate rodent carcinogenicity 

studies (MRID 47305307, mouse; 47305306, rat).

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and 

used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human 

exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = 

uncertainty factor. UFA = extrapolation from animal to human (intraspecies). UFH = potential variation in sensitivity 

among members of the human population (interspecies). FQPA SF = FQPA Safety Factor. PAD = population-adjusted 

dose (a = acute, c = chronic). RfD = reference dose. 

VII. Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned when dietary risk 

exceeds 100% of the PAD. The DEEM-FCID analyses estimate the dietary exposure of 

the U.S. population and various population subgroups. The results reported in Table 4

are for the general U.S. Population, all infants (<1 year old), children 1-2, children 3-5, 

children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50-99 years. 

Results of Acute and Chronic Dietary (Food and Drinking Water) Exposure Analysis

Acute dietary risk analyses were conducted with the DEEM-FCID model to form a

conservative evaluation of exposure for imazosulfuron. At the 95th percentile of 
Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 403364

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exposure, all acute analyses yielded risk estimates well below the 100% of the aPAD 

threshold level of concern for each population subgroup. For food and drinking water, 

the U.S. Population subgroup acute aggregate dietary risk was calculated at <1% of the 

aPAD with an exposure level of 0.015 mg/kg/day. For the subgroup with the highest 

calculated exposure, all infants, acute aggregate dietary risk occupied 1.2% of the aPAD 

with an exposure of 0.048 mg/kg/day. An overview summarizing the results of the acute 

dietary assessments with the population subgroup having the highest exposure noted in 

bold is presented in Table 4.

Chronic dietary risk analyses were conducted with the DEEM-FCIDTM model to form a

conservative evaluation of exposure for imazosulfuron. All chronic analyses yielded risk 

estimates well below the 100% of the cPAD threshold level of concern for each 

population subgroup. For food and drinking water, the U.S. Population subgroup chronic 

aggregate dietary risk was calculated at <1.0% of the cPAD with an exposure level of 

0.0060 mg/kg/day. For the subgroup with the highest calculated exposure, all infants, 

chronic aggregate dietary risk occupied 2.0% of the cPAD with an exposure of 0.020

mg/kg/day. An overview summarizing the results of the chronic dietary assessment with 

the population subgroup having the highest exposure noted in bold is presented in Table 

4.

Table 4. Summary of Dietary (Food and Drinking Water) Exposure and Risk for Imazosulfuron

Population Subgroup

Acute Dietary

(95th Percentile) Chronic Dietary Cancer

Dietary 

Exposure 

(mg/kg/day)

% aPAD*

Dietary 

Exposure

(mg/kg/day)

% cPAD*

Dietary 

Exposure

(mg/kg/day)

Risk

General U.S. Population 0.015361 < 1 0.005957 < 1

N/A N/A

All Infants (<1 year old) 0.047750 1.2 0.015210 2.0

Children 1-2 years old 0.023786 < 1 0.008712 1.2

Children 3-5 years old 0.019404 < 1 0.007367 1.0

Children 6-12 years old 0.014765 < 1 0.005292 < 1

Youth 13-19 years old 0.012823 < 1 0.004362 < 1

Adults 20-49 years old 0.015069 < 1 0.005927 < 1

Adults 50 -99 years old 0.013496 < 1 0.005848 < 1

Females 13-49 years old 0.015336 < 1 0.005898 < 1

* % PADs are reported to 2 significant figures. The values for the highest population for each type of risk 

assessment are bolded.

VIII.Characterization of Inputs/Outputs

The acute and chronic dietary assessments conducted with DEEM-FCID for 

imazosulfuron are unrefined analyses. In addition to tolerance-level residues, default 

processing factors, and 100% crop treated assumptions, it utilized conservative EDWCs 

derived through EFED modeling which are unlikely to underestimate the concentration of 

imazosulfuron in drinking water. The present DEEM-FCID analysis assumes that all 

drinking water will contain imazosulfuron at the highest acute EDWC levels modeled by 

EFED for groundwater or surface water. For these reasons, it can be concluded that the 
Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 403364

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DEEM-FCID analysis does not underestimate risk from acute and chronic exposure to

imazosulfuron for the general U.S. population and all its subgroups.

IX. Conclusions

The conservative acute and chronic dietary risk assessments conducted with DEEMFCID indicate that exposures to imazosulfuron are below HED’s level of concern. The 

acute dietary risk to imazosulfuron is estimated to be <1.0% of the aPAD for the general 

U.S. population and 1.2% of the aPAD for the most highly exposed population subgroup, 

all infants (<1year old). The chronic dietary risk to imazosulfuron is estimated to be 

<1.0% of the cPAD for the general U.S. population and 2.0% of the cPAD for the most 

highly exposed population subgroup, all infants (<1year old). Therefore, HED does not 

have any concerns for the proposed new tolerances of imazosulfuron. 

X. List of Attachments

1. Attachment 1: Acute and Chronic Dietary Exposure (food + water) Input File.

2. Attachment 2: Acute Dietary Exposure (food + water) Results File.

3. Attachment 3: Chronic Dietary Exposure (food + water) Results File.
Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 403364

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ATTACHMENT 1

Filename: C:\Documents and Settings\cwalls\My 

Documents\Cassi\HED\Imazasulfuron\2013\IMAZASULFURON FOOD AND WATER 010913.R08

Chemical: Imazasulfuron

RfD(Chronic): .75 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): 4 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 01-10-2013/11:23:52 Program ver. 3.16, 03-08-d

---------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -----

0103015000 1CD Arrowroot, flour 0.040000 1.000 1.000 

0103015001 1CD Arrowroot, flour-babyfood 0.040000 1.000 1.000 

0103017000 1CD Artichoke, Jerusalem 0.040000 1.000 1.000 

0103082000 1CD Cassava 0.040000 1.000 1.000 

0103082001 1CD Cassava-babyfood 0.040000 1.000 1.000 

0103139000 1CD Dasheen, corm 0.040000 1.000 1.000 

0103166000 1CD Ginger 0.040000 1.000 1.000 

0103166001 1CD Ginger-babyfood 0.040000 1.000 1.000 

0103167000 1CD Ginger, dried 0.040000 1.000 1.000 

0103296000 1C Potato, chips 0.040000 1.000 1.000 

0103297000 1C Potato, dry (granules/ flakes) 0.040000 6.500 1.000 

0103297001 1C Potato, dry (granules/ flakes)-b 0.040000 6.500 1.000 

0103298000 1C Potato, flour 0.040000 6.500 1.000 

0103298001 1C Potato, flour-babyfood 0.040000 6.500 1.000 

0103299000 1C Potato, tuber, w/peel 0.040000 1.000 1.000 

0103299001 1C Potato, tuber, w/peel-babyfood 0.040000 1.000 1.000 

0103300000 1C Potato, tuber, w/o peel 0.040000 1.000 1.000 

0103300001 1C Potato, tuber, w/o peel-babyfood 0.040000 1.000 1.000 

0103366000 1CD Sweet potato 0.040000 1.000 1.000 

0103366001 1CD Sweet potato-babyfood 0.040000 1.000 1.000 

0103371000 1CD Tanier, corm 0.040000 1.000 1.000 

0103387000 1CD Turmeric 0.040000 1.000 1.000 

0103406000 1CD Yam, true 0.040000 1.000 1.000 

0103407000 1CD Yam bean 0.040000 1.000 1.000 

0801375000 8A Tomato 0.040000 1.000 1.000 

0801375001 8A Tomato-babyfood 0.040000 1.000 1.000 

0801376000 8A Tomato, paste 0.040000 5.400 1.000 

0801376001 8A Tomato, paste-babyfood 0.040000 5.400 1.000 

0801377000 8A Tomato, puree 0.040000 3.300 1.000 

0801377001 8A Tomato, puree-babyfood 0.040000 3.300 1.000 

0801378000 8A Tomato, dried 0.040000 14.300 1.000 

0801378001 8A Tomato, dried-babyfood 0.040000 14.300 1.000 

0801379000 8A Tomato, juice 0.040000 1.500 1.000 

0802270000 8B Pepper, bell 0.040000 1.000 1.000 

0802270001 8B Pepper, bell-babyfood 0.040000 1.000 1.000 

0802271000 8B Pepper, bell, dried 0.040000 1.000 1.000 

0802271001 8B Pepper, bell, dried-babyfood 0.040000 1.000 1.000 

0802272000 8BC Pepper, nonbell 0.040000 1.000 1.000 

0802272001 8BC Pepper, nonbell-babyfood 0.040000 1.000 1.000 

0802273000 8BC Pepper, nonbell, dried 0.040000 1.000 1.000 

0901075000 9A Cantaloupe 0.040000 1.000 1.000 

0901187000 9A Honeydew melon 0.040000 1.000 1.000 

0901399000 9A Watermelon 0.040000 1.000 1.000 

0901400000 9A Watermelon, juice 0.040000 1.000 1.000 

1500323000 15 Rice, white 0.040000 1.000 1.000 

1500323001 15 Rice, white-babyfood 0.040000 1.000 1.000 

1500324000 15 Rice, brown 0.040000 1.000 1.000 

1500324001 15 Rice, brown-babyfood 0.040000 1.000 1.000 

1500325000 15 Rice, flour 0.040000 1.000 1.000 

1500325001 15 Rice, flour-babyfood 0.040000 1.000 1.000 

1500326000 15 Rice, bran 0.040000 1.000 1.000 

1500326001 15 Rice, bran-babyfood 0.040000 1.000 1.000 
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8601000000 86A Water, direct, all sources 0.278900 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.278900 1.000 1.000 
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ATTACHMENT 2

U.S. EPA Ver. 3.16, 03-08-d

DEEM-FCID ACUTE Analysis for IMAZASULFURON NHANES 2003-2008 2-Day

Residue file: IMAZASULFURON FOOD AND WATER 010913.R08

Adjustment factor #2 NOT used.

Analysis Date: 01-16-2013/16:29:34 Residue file dated: 01-16-2013/16:27:52

RAC/FF intake summed over 24 hours

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.015361 0.38 0.025228 0.63 0.047697 1.19 

All Infants:

 0.047750 1.19 0.064504 1.61 0.095203 2.38 

Female 13-50:

 0.015297 0.38 0.022484 0.56 0.031983 0.80 

Children 1-2:

 0.023786 0.59 0.035592 0.89 0.086784 2.17 

Children 3-5:

 0.019404 0.49 0.029755 0.74 0.047425 1.19 

Children 6-12:

 0.014765 0.37 0.023801 0.60 0.036685 0.92 

Youth 13-19:

 0.012824 0.32 0.021082 0.53 0.031881 0.80 

Adults 20-49:

 0.015069 0.38 0.022396 0.56 0.032521 0.81 

Adults 50-99:

 0.013496 0.34 0.020598 0.51 0.031943 0.80 

Female 13-49:

 0.015336 0.38 0.022483 0.56 0.031664 0.79 
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ATTACHMENT 3

U.S. EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for IMAZASULFURON NHANES 2003-2008 2-day

Residue file name: C:\Documents and Settings\cwalls\My 

Documents\Cassi\HED\Imazasulfuron\2013\IMAZASULFURON FOOD AND WATER 010913.R08

 Adjustment factor #2 NOT used.

Analysis Date 01-16-2013/16:28:13 Residue file dated: 01-16-2013/16:27:52

Reference dose (RfD, Chronic) = .75 mg/kg bw/day

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.005957 0.8%

Hispanic 0.005711 0.8%

Non-Hisp-White 0.006121 0.8%

Non-Hisp-Black 0.004924 0.7%

Non-Hisp-Other 0.006869 0.9%

Nursing Infants 0.005369 0.7%

Non-Nursing Infants 0.019605 2.6%

Female 13+ PREG 0.005613 0.7%

Children 1-6 0.007747 1.0%

Children 7-12 0.005034 0.7%

Male 13-19 0.004127 0.6%

Female 13-19/NP 0.004593 0.6%

Male 20+ 0.005543 0.7%

Female 20+/NP 0.006223 0.8%

Seniors 55+ 0.005733 0.8%

All Infants 0.015210 2.0%

Female 13-50 0.005904 0.8%

Children 1-2 0.008712 1.2%

Children 3-5 0.007367 1.0%

Children 6-12 0.005292 0.7%

Youth 13-19 0.004362 0.6%

Adults 20-49 0.005927 0.8%

Adults 50-99 0.005848 0.8%

Female 13-49 0.005898 0.8%

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