*** EO 12866 Review DRAFT – Do Not Cite, Quote or Release During the Review *** 

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1 Glymes NPRM_EO 12866_2010-04-08.doc 

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3 EO 12866 Review Draft as submitted. 

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5 ENVIRONMENTAL PROTECTION AGENCY 

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7 40 CFR Part 721 

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9 [EPA–HQ–OPPT–2009–0767; FRL–XXXX–X] 

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11 RIN 2070–AJ52

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13 Glymes; Proposed Significant New Use Rule 

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15 AGENCY: Environmental Protection Agency (EPA).

16 

17 ACTION: Proposed rule. 

18 SUMMARY: EPA is proposing a significant new use rule (SNUR) under section 

19 5(a)(2) of the Toxic Substances Control Act (TSCA) for 14 glymes. This action would 

20 require persons who intend to manufacture, import, or process these chemical substances 

21 for an activity that is designated as a significant new use by this proposed rule to notify 

22 EPA at least 90 days before commencing that activity. The required notification would 

23 provide EPA with the opportunity to evaluate the intended use and, if necessary, to 

24 prohibit or limit that activity before it occurs. 

25 

26 DATES: Comments must be received on or before [insert date [60 ] days after date of 

27 publication in the Federal Register]. 

28 ADDRESSES: Submit your comments, identified by docket identification (ID) number 

29 EPA–HQ–OPPT–2009–0767, by one of the following methods: 

30 • Federal eRulemaking Portal: http://www.regulations.gov. Follow the on-line 

31 instructions for submitting comments. 

32 • Mail: Document Control Office (7407M), Office of Pollution Prevention and Toxics 

33 (OPPT), Environmental Protection Agency, 1200 Pennsylvania Ave., NW., Washington, 

34 DC 20460–0001. 

35 • Hand Delivery: OPPT Document Control Office (DCO), EPA East Bldg., Rm. 6428, 

36 1201 Constitution Ave., NW., Washington, DC. Attention: Docket ID Number EPA–

37 HQ–OPPT–2009–0767. The DCO is open from 8 a.m. to 4 p.m., Monday through 

38 Friday, excluding legal holidays. The telephone number for the DCO is (202) 564–8930.

39 Such deliveries are only accepted during the DCO’s normal hours of operation, and 

40 special arrangements should be made for deliveries of boxed information. 
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41 Instructions: Direct your comments to docket ID number EPA–HQ–OPPT–

42 2009–0767. EPA's policy is that all comments received will be included in the docket 

43 without change and may be made available on-line at http://www.regulations.gov, 

44 including any personal information provided, unless the comment includes information 

45 claimed to be Confidential Business Information (CBI) or other information whose 

46 disclosure is restricted by statute. Do not submit information that you consider to be CBI 

47 or otherwise protected through regulations.gov or e-mail. The regulations.gov website is 

48 an “anonymous access” system, which means EPA will not know your identity or contact 

49 information unless you provide it in the body of your comment. If you send an e-mail 

50 comment directly to EPA without going through regulations.gov, your e-mail address 

51 will be automatically captured and included as part of the comment that is placed in the 

52 docket and made available on the Internet. If you submit an electronic comment, EPA 

53 recommends that you include your name and other contact information in the body of 

54 your comment and with any disk or CD-ROM you submit. If EPA cannot read your 

55 comment due to technical difficulties and cannot contact you for clarification, EPA may 

56 not be able to consider your comment. Electronic files should avoid the use of special 

57 characters, any form of encryption, and be free of any defects or viruses. 

58 Docket: All documents in the docket are listed in the docket index 

59 available at http://www.regulations.gov. Although listed in the index, some information is 

60 not publicly available, e.g., CBI or other information whose disclosure is restricted by 

61 statute. Certain other material, such as copyrighted material, will be publicly available 

62 only in hard copy. Publicly available docket materials are available electronically at 

63 http://www.regulations.gov, or, if only available in hard copy, at the OPPT Docket. The 

64 OPPT Docket is located in the EPA Docket Center (EPA/DC) at Rm. 3334, EPA West 

65 Bldg., 1301 Constitution Ave., NW., Washington, DC. The EPA/DC Public Reading 

66 Room hours of operation are 8:30 a.m. to 4:30 p.m., Monday through Friday, excluding 

67 legal holidays. The telephone number of the EPA/DC Public Reading Room is (202) 

68 566–1744, and the telephone number for the OPPT Docket is (202) 566–0280. Docket 

69 visitors are required to show photographic identification, pass through a metal detector, 

70 and sign the EPA visitor log. All visitor bags are processed through an X-ray machine 

71 and subject to search. Visitors will be provided an EPA/DC badge that must be visible at 

72 all times in the building and returned upon departure. 

73 FOR FURTHER INFORMATION CONTACT: For general information contact: 

74 Colby Lintner, Regulatory Coordinator, Environmental Assistance Division (7408M), 

75 Office of Pollution Prevention and Toxics, Environmental Protection Agency, 1200 

76 Pennsylvania Ave., NW., Washington, DC 20460–0001; telephone number: (202) 554–

77 1404; e-mail address: TSCA-Hotline@epa.gov. 

78 For technical information contact: Amy Breedlove, Chemical Control Division 

79 (7405M), Office of Pollution Prevention and Toxics, Environmental Protection Agency, 

80 1200 Pennsylvania Ave., NW., Washington, DC 20460–0001; telephone number: 202-

81 564-9823; e-mail address: breedlove.amy@epa.gov. 

82 SUPPLEMENTARY INFORMATION: 

83 
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84 I. General Information 

85 A. Does this Action Apply to Me? 

86 You may be potentially affected by this action if you manufacture, import, or 

87 process the chemicals listed in Unit II.A. 

88 

89 Potentially affected entities may include, but are not limited to: 

90 • Manufacturers, importers, or processors of one or more of subject chemical 

91 substances (North American Industrial Classification System (NAICS) codes 325 and 

92 324110), e.g., chemical manufacturing and petroleum refineries; 325199 – All other basic 

93 organic chemical manufacturing; 325910 – Printing ink manufacturing; 325510 – Paint 

94 and Coating Manufacturing; 325520 – Adhesive Manufacturing; 335912 – Principle 

95 Battery Manufacturing; and 336340 – Motor Vehicle Brake System Manufacturing. 

96 This listing is not intended to be exhaustive, but rather provides a guide for readers 

97 regarding entities likely to be affected by this action. Other types of entities not listed in 

98 this unit could also be affected. The NAICS codes have been provided to assist you and 

99 others in determining whether this action might apply to certain entities. To determine 

100 whether you or your business may be affected by this action, you should carefully 

101 examine the applicability provisions in 40 CFR 721.5. Also consult Unit II. If you have 

102 any questions regarding the applicability of this action to a particular entity, consult the 

103 technical person listed under FOR FURTHER INFORMATION CONTACT. 

104 This action may also affect certain entities through pre-existing import certification 

105 and export notification rules under TSCA. Persons who import any chemical substance 

106 governed by a final SNUR are subject to the TSCA section 13 (15 U.S.C. 2612) import 

107 certification requirements and the corresponding regulations at 19 CFR 12.118 through 

108 12.127 and 19 CFR 127.28. Those persons must certify that the shipment of the chemical 

109 substance complies with all applicable rules and orders under TSCA, including any 

110 SNUR requirements. The EPA policy in support of import certification appears at 40 

111 CFR part 707, subpart B. In addition, any persons who export or intend to export a 

112 chemical substance that is the subject of this proposed rule on or after [insert date 30 

113 days after the date of publication in the FR] are subject to the export notification 

114 provisions of TSCA section 12(b) (15 U.S.C. 2611(b)), (see 40 CFR 721.20), and must 

115 comply with the export notification requirements in 40 CFR part 707, subpart D. 

116 

117 B. What Should I Consider as I Prepare My Comments for EPA? 

118 1. Submitting CBI. Do not submit this information to EPA through 

119 regulations.gov or e-mail. Clearly mark the part or all of the information that you claim 

120 to be CBI. For CBI information in a disk or CD-ROM that you mail to EPA, mark the 

121 outside of the disk or CD-ROM that you mail to EPA, mark the outside of the disk or 

122 CD-ROM as CBI and then identify electronically within the disk or CD-ROM the 

123 specific information that is claimed as CBI. In addition to one complete version of the 

124 comment that includes information claimed as CBI (i.e., a sanitized version), a copy of 
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125 the comment that does not contain the information claimed as CBI must be submitted for 

126 inclusion in the public docket. Information so marked will not be disclosed except in 

127 accordance with procedures set forth in 40 CFR part 2. 

128 2. Tips for preparing your comments. When submitting comments, remember to: 

129 i. Identify the document by docket ID number and other identifying information 

130 (subject heading, Federal Register date and page number). 

131 ii. Follow directions. The Agency may ask you to respond to specific questions or 

132 organize comments by referencing a Code of Federal Regulations (CFR) part or section 

133 number. 

134 iii. Explain why you agree or disagree; suggest alternatives and substitute 

135 language for your requested changes. 

136 iv. Describe any assumptions and provide any technical information and/or data 

137 that you used. 

138 v. If you estimate potential costs or burdens, explain how you arrived at your 

139 estimate in sufficient detail to allow for it to be reproduced. 

140 vi. Provide specific examples to illustrate your concerns and suggest alternatives. 

141 vii. Explain your views as clearly as possible, avoiding the use of profanity or 

142 personal threats. 

143 viii. Make sure to submit your comments by the comment period deadline 

144 identified. 

145 II. Background 

146 A. What Action is the Agency Taking? 

147 EPA is proposing a significant new use rule under section 5(a)(2) of TSCA where 

148 the designated significant new use for the chemicals in Table 1 of this unit would be “use 

149 in a consumer product,” with the exception of the ongoing uses which are the excluded 

150 uses listed under “Proposed Excluded Consumer Uses,” and where the designated 

151 significant new use for the chemicals in Unit II.A.1 would be “any use.” “Consumer 

152 product” is defined at 40 CFR 721.3 as: “a chemical substance that is directly, or as part 

153 of a mixture, sold or made available to consumers for their use in or around a permanent 

154 or temporary household or residence, in or around a school, or in recreation.” Persons 

155 would be required to notify EPA at least 90 days before commencing the manufacture, 

156 import, or processing of the listed substances for the designated significant new uses. 

157 The objectives and rationale for this proposed SNUR are explained in Unit IV. 

158 

159 Table 1 – Chemicals with Use in a Consumer Product as the Proposed Significant New 

160 Use and Proposed Excluded Consumer Uses 
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161 

CAS Registry 

Number 

(CASRN) 

CA Index Name Common Name Proposed Excluded 

Consumer Uses 

110-71-4 Ethane, 1,2-dimethoxy- Monoglyme or 

Monoethylene 

glycol dimethyl 

ether 

in electrolyte 

solutions for sealed 

lithium batteries 

111-96-6 Ethane, 1,l'-oxybis[2-

methoxyDiglyme or Diethylene glycol 

dimethyl ether 

as a solvent in 

printing inks for 

consumer products 

112-36-7 Ethane, 1,l'-oxybis[2-

ethoxyEthyldiglyme or Diethylene glycol 

diethyl ether 

112-49-2 2,5,8, 11-

Tetraoxadodecane 

Triglyme or 

Triethylene glycol 

dimethyl ether 

-as a solvent in 

consumer adhesives 

-as a component of 

consumer brake 

fluids 

-as a component of 

consumer 

paint/graffiti 

removers 

-in consumer paints 

112-73-2 Butane, 1,1'-

[oxybis(2,1-

ethanediyloxy)]bisButyldiglyme or 

Diethylene glycol 

dibutyl ether 

112-98-1 5,8,11,14,17-

Pentaoxaheneicosane 

Tetraethylene glycol 

dibutyl ether 

143-24-8 2,5,8,11,14-

Pentaoxapentadecane 

Tetraglyme or 

Tetraethylene glycol 

dimethyl ether 

-as an HFC/CFC 

lubricant 

-as a solubilizing 

agent for consumer 

printing inks 

-as a coalescing agent 

in consumer paints 

629-14-1 Ethane, 1,2-diethoxy- Ethylglyme or 

Ethylene glycol 

diethyl ether 

4353-28-0 3,6, 9, 12,15-

Pentaoxaheptadecane 

Tetraethylene glycol 

diethyl ether 

23601-39-0 3, 6, 9, 12, 15, 18-

Hexaoxaeicosane 

Pentaethylene glycol 

diethyl ether 

24991-55-7 Poly(oxy-l,2-

ethanediyl), .alpha.-

methyl-.omega.-

Polyglyme or 

Polyethylene glycol 

dimethyl ether 

use in consumer paint 

strippers 
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methoxy31885-97-9 Poly(oxy-1,2-

ethanediyl), .alpha.-

butyl-.omega.-butoxyPolyethylene glycol 

dibutyl ether 

162 

163 

164 1. Chemicals with “any use” as the proposed significant new use: 

165 

166 - CASRN 51105-00-1, CA Index Name: 5,8,11,14,17,20-Hexaoxatetracosane, 

167 and Common Name: Pentaethylene glycol dibutyl ether; and, 

168 

169 - CASRN 63512-36-7; CA Index Name: 5,8,11,14-Tetraoxaoctadecane; and 

170 Common Name: Butyltriglyme or Triethylene glycol dibutyl ether. 

171 

172 B. What is the Agency's Authority for taking this Action? 

173 Section 5(a)(2) of TSCA (15 U.S.C. 2604(a)(2)) authorizes EPA to determine that 

174 a use of a chemical substance is a "significant new use." EPA must make this 

175 determination by rule after considering all relevant factors, including those listed in 

176 TSCA section 5(a)(2). Once EPA determines that a use of a chemical substance is a 

177 significant new use, TSCA section 5(a)(1)(B) requires persons to submit a significant 

178 new use notice (SNUN) to EPA at least 90 days before they manufacture, import, or 

179 process the chemical substance for that use (15 U.S.C. 2604(a)(1)(B)). As described in 

180 Unit II.C., the general SNUR provisions are found at 40 CFR Part 721, Subpart A. 

181 

182 C. Applicability of General Provisions

183 

184 General provisions for SNURs appear under 40 CFR part 721, subpart A. These 

185 provisions describe persons subject to the rule, recordkeeping requirements, exemptions 

186 to reporting requirements, and applicability of the rule to uses occurring before the 

187 effective date of the final rule. Provisions relating to user fees appear at 40 CFR part 

188 700. According to 40 CFR 721.1(c), persons subject to SNURs must comply with the 

189 same notice requirements and EPA regulatory procedures as submitters of 

190 Premanufacture Notices (PMNs) under TSCA section 5(a)(1)(A). In particular, these 

191 requirements include the information submissions requirements of TSCA section 5(b) 

192 and 5(d)(1), the exemptions authorized by TSCA section 5(h)(1), (h)(2), (h)(3), and 

193 (h)(5), and the regulations at 40 CFR part 720. Once EPA receives a SNUN, EPA may 

194 take regulatory action under TSCA section 5(e), 5(f), 6 or 7 to control the activities on 

195 which it has received the SNUN. If EPA does not take action, EPA is required under 

196 TSCA section 5(g) to explain in the Federal Register its reasons for not taking action. 

197 

198 Persons who export or intend to export a chemical substance identified in a proposed 

199 or final SNUR are subject to the export notification provisions of TSCA section 12(b). 

200 The regulations that interpret TSCA section 12(b) appear at 40 CFR part 707, subpart D. 

201 Persons who import a chemical substance identified in a final SNUR are subject to the 

202 TSCA section 13 import certification requirements, codified at 19 CFR 12.118 through 
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203 12.127 and 19 CFR 127.28. Such persons must certify that the shipment of the chemical 

204 substance complies with all applicable rules and orders under TSCA, including any 

205 SNUR requirements. The EPA policy in support of import certification appears at 40 

206 CFR part 707, subpart B. 

207 

208 III. Summary of Exposure and Hazard Information on the Glymes 

209 

210 A. What are the Chemicals included in the SNUR? 

211 

212 The glymes in the category include the 14 chemical substances shown in Table 1 

213 of the regulatory text. 

214 

215 B. What are the Uses of these Chemicals? 

216 

217 To identify the ongoing consumer uses of these glymes, as well as potential 

218 industrial uses, EPA used information submitted under the 2006 Inventory Update 

219 Reporting (IUR) rule, contacted manufacturers, searched business periodicals, and 

220 searched other available sources. 

221 

222 Monoglyme is used in consumer products in electrolyte solutions for sealed lithium 

223 batteries. Industrial uses include printed circuit board manufacturing; in reactions with 

224 strong bases; in mixtures where solvent separation and recovery is necessary; as an inert 

225 special solvent; and as a solvent in pharmaceutical production (Ref. 1, pg. 9). 

226 

227 Diglyme is used as a solvent in printing inks for consumer products and industrially 

228 as a solvent in a variety of processes (Ref. 1, pg. 10). 

229 

230 Triglyme is used in consumer products in consumer brake fluids, as a solvent in 

231 consumer adhesives, as a component of consumer paint and graffiti removers and in 

232 consumer paints. Industrial uses include generation of chemicals, use as a reaction 

233 solvent, and use as a binding agent in porcelain powders (Ref. 1, pg. 11). 

234 

235 Tetraglyme is used in consumer products as a solubilizing agent for consumer 

236 printing inks, as a coalescing agent in consumer paints, and as an HFC/CFC lubricant 

237 which may be used in consumer air conditioners. Industrial uses include use as a 

238 solubilizing agent in textiles and plastics, as a dye fixation additive for cotton textiles, as 

239 a fungicide process solvent, and as a gas scrubbing agent (Ref. 1, pg. 12). 

240 

241 Polyglyme is used in consumer paint strippers. Industrial uses include use as special, 

242 high boiling solvents for chemical reactions, use as a solubilizing agent for plastic, 

243 textile, and paper processes, and use as a gas scrubbing agent (Ref. 1, pg. 13). 

244 

245 Ethyldiglyme, butyldiglyme, tetraethylene glycol dibutyl ether, ethylglyme, 

246 tetraethylene glycol diethyl ether, pentaethylene glycol diethyl ether, and polyethylene 

247 glycol dibutyl ether, have no known uses in consumer products. Industrial uses of these 

248 glymes can include use: as a high-boiling solvent for nitrocellulose, resins, and lacquers; 

249 as a solubilizer in organic synthesis; as a solvent in the production of plastic resins and 
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250 compounds, rubber chemicals; as a solvent for conductive printing ink; in the production 

251 of printed circuit etchants; in the preparation of and reaction with Grignard reagents; in 

252 metal extractions; as a solvent in pharmaceutical syntheses; in the production of coatings; 

253 and as a gas scrubbing liquid (Ref. 1, pgs. 14-19). 

254 

255 The chemicals listed in Unit II.A.1., pentaethylene glycol dibutyl ether and 

256 butyltriglyme, have no known uses (Ref. 1, pg. 19). 

257 

258 C. What are the Production Levels of these Chemicals?

259 

260 The 2006 Inventory Update Reporting (IUR) regulation required manufacturers and 

261 importers of certain chemical substances included on the TSCA Chemical Substance 

262 Inventory to report site and manufacturing information for chemicals manufactured 

263 (including imported) in amounts of 25,000 pounds or greater at a single site. Table 2 

264 summarizes 2006 and prior year IUR data for the 14 glymes. For monoglyme and 

265 diglyme, EPA expects that production will continue. For triglyme and ethylglyme, 

266 predicting future production is infeasible, although ethylglyme production appears to be 

267 increasing. For ethyldiglyme, butyldiglyme, and tetraglyme, EPA expects that 

268 production will remain at the previous levels. Production of pentaethylene glycol diethyl 

269 ether appears to be steadily increasing. For polyglyme, EPA expects that production will 

270 continue to decrease and/or remain below the reporting level. For tetraethylene glycol 

271 dibutyl ether, tetraethylene glycol diethyl ether, polyethylene glycol dibutyl ether, 

272 pentaethylene glycol dibutyl ether, and butyltriglyme, EPA expects that production of 

273 these chemical substances, if any, will remain below reporting levels. 

274 

275 Table 2 – Production Reporting Amounts to IUR 1986-2006 (Ref. 1) 

276 

Common Name 2006 IUR 

Reporting 

Previous IUR Reporting 

Monoglyme >1M - <10M lbs 1986: >10K-<500K lbs 

1990-2002: >1M - <10M lbs 

each year 

Diglyme >1M - <10M lbs 1986-2002: >1M - <10M lbs 

each year 

Ethyldiglyme >10K - <500K lbs 1986-2002: >10K – <500K lbs 

each year 

Triglyme No report 1994-2002: >10K - <500K lbs 

each year 

Butyldiglyme >10K - <500K lbs 1990-2002: >10K - <500K lbs 

each year 

Tetraethylene glycol 

dibutyl ether 

No report No reports 1986-2002 

Tetraglyme >10K - <500K lbs 1986-2002: >10K - <500K lbs 

each year 

Ethylglyme >10K - <500K lbs 1986-2002 : no reports 

Tetraethylene glycol No report No reports 1986-2002 
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diethyl ether 

Pentaethylene glycol 

diethyl ether 

>1M - <10M lbs 1986 & 1990: >10K - <500K 

lbs each year 

1994: no report 

1998: >500K - <1M lbs 

2002: >1M - <10M lbs 

Polyglyme No report 1986: >1M - <10M lbs 

1994: 0; 1998, 

2002: >10K - <500K lbs each 

year 

Polyethylene glycol 

dibutyl ether 

No report No reports 1986-2002 

Pentaethylene glycol 

dibutyl ether 

No report No reports 1986-2002 

Butyltriglyme No report No reports 1986-2002 

277 

278 D. What are the Potential Routes and Sources of Exposure? 

279 

280 Exposures to the environment, consumers, and general population 

281 

282 Monoglyme, diglyme, ethyldiglyme, triglyme, butyldiglyme, and ethylglyme are 

283 included in the category of chemicals reported as “certain glycol ethers” under the ID 

284 number N230 in the Toxics Release Inventory (TRI) (Ref. 2). The total release reported 

285 to the TRI in 2007 from all reporting sites was 18,476,420 pounds. This total includes air 

286 releases of 16,416,033 pounds from on-site fugitive and point sources, in addition to on287 site water releases of 87,035 pounds. Most of the remaining volume of release was deep288 well injected, sent to land treatment, transferred for energy recovery or transferred to a 

289 POTW. Release information about the individual glymes within the larger glycol ether 

290 category is not known (Ref. 3). Manufacturers, importers, or processors are required to 

291 report releases of chemicals on the TRI when total manufacturing, imports or processing 

292 by a facility equals 25,000 pounds/year for the chemicals combined. 

293 

294 Ethylglyme was found in the US EPA Office of Water STORET database 

295 indicating potential environmental exposure since this chemical was found in ground 

296 water and/or surface water (Ref. 3). 

297 

298 Monitoring data indicate that the general population may be exposed to diglyme 

299 and ethyldiglyme via inhalation of vehicle exhaust and ingestion of contaminated 

300 drinking water (Refs. 4 and 5). Diglyme was listed as a contaminant found in drinking 

301 water (Ref. 4). 

302 

303 Diglyme has been detected in diluted vehicle exhaust from a light-duty truck 

304 using different fuel types (Ref. 4). 

305 

306 Industrial manufacture and processing may result in the release of glymes to the 

307 environment through various waste streams (Ref. 4). Diglyme, ethyldiglyme, and 
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308 ethylglyme have been found at measurable concentrations in industrial wastewater 

309 treatment systems (Refs. 4, 5, and 6). Wastewater treatment systems discharge to either 

310 surface waters or publicly owned treatment works. Either of these two discharge options 

311 could result in exposures for the general population and the environment to these 

312 chemicals. 

313 

314 Ethyldiglyme has been qualitatively detected in drinking water from Cincinnati, 

315 OH; in ground water from the Hipps Road Landfill in Jacksonville, FL; in trench 

316 leachates from Maxey Flats, KY and West Valley, NY low-level radioactive waste 

317 disposal sites and in advanced waste treatment water from Lake Tahoe, CA, Pomona, 

318 CA, and Blue Plains, Washington, DC (Ref. 5). 

319 

320 Ethylglyme has been detected in western Cleveland, OH wastewater influents at 

321 140 μg/L and it was identified in Chicago Central water works water (treated and 

322 untreated) at 2 μg/L (Ref. 6). 

323 

324 Monitoring data for ethylglyme indicates that the general population may be 

325 exposed to the chemical through releases from manufacturing facilities. The general 

326 population can then be exposed via inhalation of ambient air, ingestion of drinking water, 

327 and dermal contact with these substances and other products containing these chemicals. 

328 Evidence of releases from industrial manufacturing and processing is demonstrated by 

329 concentrations of 400 mg/L of diglyme which have been found in activated sludge from 

330 the waste treatment facility of the industry producing the chemical (Ref. 6). 

331 

332 For the remaining chemicals in Table 1 or Unit II.A.1., little or no release 

333 information was found. 

334 

335 EPA’s Source Ranking Databank (Ref. 7) shows metal polish and polishing cloths 

336 and papers as containing ethylglyme. Most of the entries into this databank for consumer 

337 products are from the late 1990s and therefore may not still be current. If ethylglyme is 

338 still found in these products, however, there is potential that consumers and children 

339 might be exposed to this chemical from these consumer products. Furthermore, 

340 production of ethylglyme appears to be increasing. 

341 

342 Based on IUR data and communications with manufacturers, EPA believes that 

343 monoglyme is used as a component of lithium batteries and diglyme is used in printing 

344 inks, both of which are consumer applications of monoglyme. It is believed that disposal 

345 of the lithium batteries containing monoglyme and paper with printing inks containing 

346 diglyme could present the potential for release of these chemicals to environmental media 

347 and subsequent exposure to humans and ecological receptors. 

348 

349 Occupational exposure 

350 

351 Occupational exposure to these chemicals may occur through inhalation and 

352 dermal contact at workplaces where the chemicals are produced or used. Monoglyme, 

353 diglyme, ethylglyme, ethyldiglyme, triglyme, and tetraethylene glycol diethyl ether all 
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354 have vapor pressures high enough to potentially result in significant exposures to workers 

355 if they are near the chemical (Refs. 8, 9, 3, and 10). Based on IUR data, ethyldiglyme, 

356 butyldiglyme, tetraglyme, pentaethylene glycol diethyl ether, and polyglyme are 

357 manufactured in liquid forms, and worker exposures through dermal contact are possible 

358 (Ref. 10). These chemicals do not have Occupational Safety and Health Administration 

359 (OSHA) Permissible Exposure Limits (Refs. 8, 9, and 3). Ferro Corporation, in their 

360 publications, recommended a Threshold Limit Value (TLV) for glycol ethers of 5 ppm 

361 (Time Weighted Average (TWA)) with a Short Term Exposure Limit (STEL) of 25 ppm. 

362 The 15-minute STEL should not be achieved more than 4 times in 8 hours. For women of 

363 child-bearing potential, Ferro recommended a TLV of 1 ppm with a STEL of 5 ppm (Ref. 

364 11). Based on the 2006 IUR reports, the maximum total number of potentially exposed 

365 industrial workers to monoglyme and ethylglyme during manufacturing and industrial 

366 processing and use is less than 100 each, and the maximum total number of workers 

367 likely to be exposed to diglyme was between 100 and 999 workers. There may, however, 

368 be additional potentially exposed industrial workers who are not included in these 

369 estimates since not all production volume may have been accounted for in the IUR 

370 (production below 25,000 pounds at a site does not have to be reported to the IUR), and 

371 commercial workers may be exposed as well (Refs. 8, 9, and 12). 

372 

373 E. What are the Potential Health Effects of these Chemicals?

374 

375 Toxicology studies in laboratory animals have shown that exposure to 

376 monoglyme results in hemolytic (blood) effects, and developmental and reproductive 

377 toxicity. The acute toxicity of monoglyme is low via oral, dermal and inhalation routes 

378 of exposure. The potential toxicity from repeated exposure to monoglyme was assessed 

379 using a major metabolite, 2-methoxyethanol (CASRN 109-86-4). Oral 90-day studies of 

380 2-methoxyethanol in rats and mice showed testicular degeneration and adverse effects on 

381 the process of blood cell formation. The lowest observed adverse effect level (LOAEL) in 

382 rats was 70 mg/kg-day; the LOAEL in mice was 300 mg/kg-day. An oral prenatal 

383 developmental toxicity study of monoglyme in rats showed fetal mortality at doses as low 

384 as 60 mg/kg-day, and edema at doses as low as 30 mg/kg-day. An oral prenatal 

385 developmental toxicity study of monoglyme in mice showed reduced fetal body weight 

386 and increased skeletal defects at 250 mg/kg-day. Available data also suggest that 

387 monoglyme has the potential to be genotoxic (Ref. 13). 

388 

389 Toxicology studies in laboratory animals have shown that exposure to diglyme 

390 results in hemolytic (blood) effects, and developmental and reproductive toxicity. The 

391 acute toxicity of diglyme to rats via the oral and inhalation routes of exposure is low. 

392 The toxicity profile following repeated exposures to diglyme is similar to the profile for 

393 monoglyme. Rats showed testicular degeneration and hemolytic effects following 

394 inhalation exposure to diglyme for two weeks at concentrations as low as 0.6 mg/L-day; a 

395 NOAEL was not established. An inhalation dominant-lethal study in rats showed a 

396 reduced pregnancy rate at 5.5 mg/L-day. An oral prenatal developmental toxicity study 

397 in mice showed effects on fetal growth and viability, and an increase in malformations at 

398 125 mg/kg-day; the NOAEL was 62.5 mg/kg-day. In vitro gene mutation and in vivo 

399 chromosomal aberration tests were negative (Ref. 14). 

400 
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401 Toxicology studies in laboratory animals have shown that exposure to 

402 ethylglyme results in developmental toxicity. The acute toxicity of ethylglyme is low in 

403 rats. Oral prenatal developmental toxicity studies of ethylglyme in mice and rabbits 

404 showed a significant decrease in fetal body weight and viability, and a significant 

405 increase in malformations; the NOAEL for developmental toxicity was 50 mg/kg-day in 

406 mice and 25 mg/kg-day in rabbits (Ref. 6). 

407 

408 Based on a review of the literature, there is insufficient information available to 

409 arrive at any health effects related conclusions for the remaining chemicals in Table 1 or 

410 Unit II.A.1. 

411 

412 IV. Rationale and Objectives 

413 A. Rationale

414 

415 EPA has concerns about the 14 glymes listed in this SNUR, all of which have 

416 similar chemical structures. EPA is concerned about the reproductive and/or 

417 developmental toxicity of monoglyme, diglyme, and ethylglyme and believes that 

418 individuals could suffer adverse effects from their use. In addition, EPA has concerns 

419 about the remaining 11 glymes due to the lack of available use, exposure, and toxicity 

420 information. Currently, exposure to monoglyme in lithium batteries is very limited since 

421 the batteries are sealed. The amount of exposure to diglyme in printing inks is less 

422 certain, but any additional use would increase the existing exposure to the chemical. 

423 Ethylglyme currently has no consumer uses but has been found in water sources and 

424 given its toxicity, EPA would be concerned if this chemical became prevalent in 

425 consumer products. EPA further believes that the use of any of these chemicals in 

426 consumer products, beyond the limited, current uses, would significantly increase the 

427 magnitude and duration of exposure to humans and the environment over that which 

428 would otherwise exist and that such increase should not occur without opportunity for 

429 EPA review. Finally, for pentaethylene glycol dibutyl ether and butyltriglyme, EPA 

430 believes that any use of these chemicals would significantly increase the magnitude and 

431 duration of exposure to humans and the environment over that which currently occurs. 

432 

433 On March 18, 2008, EPA published risk based prioritization related documents on 

434 monoglyme and diglyme (Refs. 8, 9, 13, and 14), which indicated that it appeared these 

435 two chemicals are used in consumer products and also indicated EPA’s concerns about 

436 the potential health effects of these two chemicals. Studies on monoglyme and diglyme 

437 indicate adverse health effects concerning reproductive and developmental toxicity, as 

438 well as on blood and blood-forming organs. Studies on ethylglyme show developmental 

439 toxicity as well as potential for gene mutation. Several manufacturers initially responded 

440 that, with the exception of monoglyme use in sealed lithium batteries, there are no 

441 consumer uses. Follow up contact with manufacturers revealed some additional potential 

442 consumer uses and raised questions about some of the other uses. For monoglyme, 

443 diglyme, and ethylglyme, as well as the remaining 11 chemicals, the level of toxicity is 

444 uncertain and/or the type and extent of the use of the chemical is unclear. EPA is 

445 proposing to issue this SNUR to require notification prior to any new manufacturing, 

446 importing, or processing of these chemicals for consumer uses (with specified 
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447 exceptions), or in some cases all uses. EPA intends to continue to monitor production, 

448 use and other relevant information on the subject substances and, where appropriate, 

449 initiate further action. 

450 

451 EPA previously published a SNUR on November 29, 2005, (70 FR 71401), (FRL 

452 7740-7), on a major metabolite of monoglyme, 2-methoxyethanol (2-ME), CASRN 109-

453 86-4, requiring notice to the Agency before 2-ME is used in a consumer product (40 CFR 

454 721.10001) (Ref. 15). 

455 

456 B. Objectives 

457 

458 Based on the considerations in Unit III., EPA wants to achieve the following objectives 

459 with regard to the significant new use(s) that are designated in this proposed rule: 

460 

461 1. EPA would receive notice of any person’s intent to manufacture, import, or 

462 process the glymes listed in Table 1 and Unit II.A.1. for the described significant new 

463 uses before that activity begins. 

464 

465 2. EPA would have an opportunity to review and evaluate data submitted in a 

466 SNUN before the notice submitter begins manufacturing, importing or processing of 

467 the glymes listed in Table 1 and Unit II.A.1. for the described significant new uses. 

468 

469 3. EPA would be able to regulate prospective uses of the glymes listed in Table 1 and 

470 Unit II.A.1. before the described significant new uses of the chemical substance occur, 

471 provided that regulation is warranted pursuant to TSCA sections 5(e), 5(f), 6 or 7. 

472 

473 V. Significant New Use Determination 

474 

475 Section 5(a)(2) of TSCA states that EPA's determination that a use of a chemical 

476 substance is a significant new use must be made after consideration of all relevant factors 

477 including: 

478 

479 • The projected volume of manufacturing and processing of a chemical substance. 

480 

481 • The extent to which a use changes the type or form of exposure of human beings 

482 or the environment to a chemical substance. 

483 

484 • The extent to which a use increases the magnitude and duration of exposure of 

485 human beings or the environment to a chemical substance. 

486 

487 • The reasonably anticipated manner and methods of manufacturing, processing, 

488 distribution in commerce, and disposal of a chemical substance. 

489 

490 In addition to these factors enumerated in TSCA section 5(a)(2), the statute authorizes 

491 EPA to consider any other relevant factors. 

492 
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493 To develop its determination of what would constitute a significant new use of the 

494 glymes listed in Table 1 and Unit II.A.1., EPA considered relevant information about the 

495 toxicity of these substances, likely human exposures and environmental releases 

496 associated with possible uses, and the four factors listed in section 5(a)(2) of TSCA. 

497 

498 Based on the relevant factors mentioned in this unit, and addressed in this SNUR, 

499 EPA has determined that the manufacture, import, or processing of ethyldiglyme, 

500 butyldiglyme, tetraethylene glycol dibutyl ether, ethylglyme, tetraethylene glycol diethyl 

501 ether, pentaethylene glycol diethyl ether, and polyethylene glycol dibutyl ether for any 

502 use in a consumer product is a significant new use. EPA has also determined that the 

503 manufacture, import, or processing of monoglyme, diglyme, triglyme, tetraglyme, 

504 polyglyme for any use in a consumer product, other than for the uses listed in Table 1, is 

505 a significant new use. In addition, EPA has determined that the manufacture, import, or 

506 processing of pentaethylene glycol dibutyl ether and butyltriglyme for any use is a 

507 significant new use. 

508 

509 VI. Request for Public Comment 

510 

511 EPA welcomes comments on any aspect of this SNUR. Information available 

512 about toxicity and exposure would assist EPA to evaluate the level of risk posed by all of 

513 the chemicals. This unit also describes the specific use information for which EPA 

514 would find comments especially helpful. 

515 

516 In order to ascertain if there are any ongoing uses of these glymes, EPA used 

517 information submitted under the IUR rule, contacted manufacturers, searched business 

518 periodicals, and searched other available sources. In some instances, EPA could confirm 

519 the existence of an ongoing use in a consumer product from the information reviewed. In 

520 other instances, the results of EPA’s search were unclear, and EPA could not confirm 

521 whether certain reported consumer product uses were actual ongoing uses. 

522 

523 Therefore, EPA is requesting public comment on whether any of the additional 

524 unconfirmed uses listed in this unit are actual, ongoing uses in a consumer product, and 

525 whether there are any other ongoing uses in a consumer product of the chemicals listed in 

526 Table 1. For pentaethylene glycol dibutyl ether and butyltriglyme, EPA is requesting 

527 public comment on whether there are any ongoing uses at all (consumer or industrial). 

528 EPA does not anticipate that it will add additional exclusions to the final rule, beyond 

529 those listed in Table 1, except where public comment adequately substantiates the 

530 existence of such ongoing use. 

531 

532 Table 3 – Reported Consumer Uses of Glymes that are Unconfirmed 

533 

Common Name Additional Unconfirmed Reports of Use 

(In addition to any confirmed ongoing 

consumer uses listed in Table 1) 

Monoglyme Treat aluminum surfaces to ensure surfaces are 

less reactive, inner and outer layer etching of 
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printed circuit board manufacturing. 

Diglyme Component in automotive care products, a 

component of brake fluid, a component in 

paints and coatings, and a component in 

adhesives and sealants. 

Ethyldiglyme Component in paint and paint varnishes, use in 

coatings manufacturing, use in adhesives 

manufacturing, and as a solvent in printing 

Triglyme None in consumer products 

Butyldiglyme None in consumer products 

Tetraethylene glycol 

dibutyl ether 

Use as an ingredient in consumer brake fluid 

Tetraglyme Use in fabrics, textiles and apparel 

Ethylglyme Use as a solvent in consumer paint production, 

use as an adhesive solvent, use as a 

polycarbonate swelling agent, use in consumer 

polishes and related products 

Tetraethylene glycol 

diethyl ether 

Use as an ingredient in consumer brake fluid 

Pentaethylene glycol 

diethyl ether 

Use as an ingredient in consumer brake fluid, 

use in the soldering of electronic circuit boards 

Polyglyme Use in adhesive removers, use in fragrance 

production, use in anti-fog compounds, use in 

brake fluid, use in automotive care products, 

and use in paper products 

Polyethylene glycol 

dibutyl ether 

Use in the production of gel laundry detergents 

Pentaethylene glycol 

dibutyl ether 

None 

Butyltriglyme None 

534 

535 VII. Alternatives 

536 

537 Before proposing this SNUR, EPA considered promulgating a TSCA section 8(a) 

538 reporting rule for these glymes. Under a TSCA section 8(a) rule, EPA could, among 

539 other things, generally require persons to report information to the Agency when they 

540 intend to manufacture, import, or process a listed chemical for a specific use or any use. 

541 However, for these glymes, the use of TSCA section 8(a) rather than SNUR authority 

542 would have several limitations. First, if EPA was to require reporting under TSCA 

543 section 8(a) instead of TSCA section 5(a), EPA would not have the opportunity to review

544 human and environmental hazards and exposures associated with the proposed significant 

545 new use and, if necessary, take immediate follow-up regulatory action under TSCA 

546 sections 5(e) or 5(f) to prohibit or limit the activity before it begins. In addition, EPA 

547 may not receive important information from small businesses, because such firms 

548 generally are exempt from TSCA section 8(a) reporting requirements. In view of the 

549 level of health and environmental concerns about monoglyme, diglyme, and ethylglyme
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550 if used for the proposed significant new use, and the lack of information to be able to 

551 judge exposure for the remaining glymes, EPA believes that a TSCA section 8(a) rule for 

552 this substance would not meet EPA's regulatory objectives. 

553 

554 VIII. Applicability of Rule to Uses Occurring Before Effective Date of the Final 

555 Rule 

556 

557 As discussed in the Federal Register of April 24, 1990 (55 FR 17376), EPA has 

558 decided that the intent of section 5(a)(1)(B) of TSCA is best served by designating a use 

559 as a significant new use as of the date of publication of the proposed rule rather than as of 

560 the effective date of the final rule. If uses begun after publication of the proposed rule 

561 were considered ongoing rather than new, it would be difficult for EPA to establish 

562 SNUR notice requirements, because a person could defeat the SNUR by initiating the 

563 proposed significant new use before the rule became final, and then argue that the use 

564 was ongoing as of the effective date of the final rule. Thus, persons who begin 

565 commercial manufacture, import, or processing of the chemical substance(s) that would 

566 be regulated through this proposed rule, if finalized, would have to cease any such 

567 activity before the effective date of the rule if and when finalized. To resume their 

568 activities, these persons would have to comply with all applicable SNUR notice 

569 requirements and wait until the notice review period, including all extensions, expires. 

570 EPA has promulgated provisions to allow persons to comply with this SNUR before the 

571 effective date. If a person were to meet the conditions of advance compliance under 

572 section 721.45(h), that person would be considered to have met the requirements of the 

573 final SNUR for those activities. 

574 

575 IX. Test Data and Other Information 

576 

577 EPA recognizes that TSCA section 5 does not require developing any particular test 

578 data before submission of a SNUN. Persons are required only to submit test data in their 

579 possession or control and to describe any other data known to or reasonably ascertainable 

580 by them (15 U.S.C. 2604(d); 40 CFR 721.25). However, as a general matter, EPA 

581 recommends that SNUN submitters include data that would permit a reasoned evaluation 

582 of risks posed by the chemical substance during its manufacture, import, processing, use, 

583 distribution in commerce, or disposal. EPA encourages persons to consult with the 

584 Agency before submitting a SNUN. As part of this optional pre-notice consultation, EPA 

585 would discuss specific data it believes may be useful in evaluating a significant new use. 

586 SNUNs submitted for significant new uses without any test data may increase the 

587 likelihood that EPA will take action under TSCA section 5(e) to prohibit or limit 

588 activities associated with this chemical. 

589 

590 SNUN submitters should be aware that EPA will be better able to evaluate SNUNs 

591 that provide detailed information on: 

592 

593 1. Human exposure and environmental releases that may result from the significant 

594 new uses of the chemical substances. 

595 2. Potential benefits of the chemical substances. 
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596 3. Information on risks posed by the chemical substances compared to risks posed 

597 by potential substitutes. 

598 

599 X. SNUN Submissions 

600 

601 EPA recommends that submitters consult with the Agency prior to submitting a 

602 SNUN to discuss what data may be useful in evaluating a significant new use. 

603 Discussions with the Agency prior to submission can afford ample time to conduct any 

604 tests that might be helpful in evaluating risks posed by the substance. According to 40 

605 CFR 721.1(c), persons submitting a SNUN must comply with the same notice 

606 requirements and EPA regulatory procedures as persons submitting a PMN, including 

607 submission of test data on health and environmental effects as described in 40 CFR 

608 720.50. 

609 

610 SNUNs must be mailed to the Environmental Protection Agency, OPPT Document 

611 Control Office (7407M), 1200 Pennsylvania Avenue, NW., Washington, D.C. 20460-

612 0001. Information must be submitted in the form and manner set forth in EPA Form No. 

613 7710-25. This form is available from the Environmental Assistance Division (7408M), 

614 1200 Pennsylvania Avenue, NW., Washington, D.C. 20460-0001 (see 40 CFR 721.25 

615 and 720.40). Forms and information are also available electronically at 

616 http://www.epa.gov/opptintr/newchems/pubs/pmnforms.htm. 

617 XI. Economic Analysis 

618 A. SNUNs

619 

620 EPA has evaluated the potential costs of establishing SNUR reporting requirements 

621 for potential manufacturers, importers, and processors of the chemical substances 

622 included in this proposed rule. While most businesses are subject to a $2,500 user fee 

623 required by 40 CFR 700.45(b)(2)(iii), small businesses with annual sales of less than $40 

624 million when combined with those of the parent company (if any) are subject to a 

625 reduced user fee of $100 (40 CFR 700.45(b)(1)). The costs of submission of SNUNs will 

626 not be incurred by any company unless a company decides to pursue a significant new 

627 use as defined in this proposed SNUR. Furthermore, EPA believes that the expense of 

628 submitting a notice (approximately $6,000 plus the user fee) is unlikely to discourage 

629 innovations of high potential value. EPA's complete economic analysis is available in the 

630 public docket for this proposed rule (Ref. 16).

631 

632 B. Export Notification

633 

634 Under section 12(b) of TSCA and the implementing regulations at 40 CFR part 

635 707, subpart D, exporters must notify EPA if they export or intend to export a chemical 

636 substance or mixture for which, among other things, a rule has been proposed or 

637 promulgated under TSCA section 5. For persons exporting a substance the subject of a 

638 SNUR, a one-time notice must be provided for the first export or intended export to a 

639 particular country. EPA estimates the one-time cost to be approximately $937 per 

640 exporter including mailing costs. The total costs of export notification will vary by 
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641 chemical, depending on the number of required notifications (i.e., the number of 

642 countries to which the chemical is exported). Because EPA is unable to make an estimate 

643 of the likely number of export notifications for the chemicals covered in this proposed 

644 SNUR, a total export notification cost is not available. 

645 

646 XII. References 

647 

648 The sources listed in this unit were used as references for this SNUR and are included 

649 in the public docket for this action, EPA-HQ-OPPT-2009-0767. 

650 

651 1. Wilson, Kimberly; Tome, Alice; and Narayan, Tulika, Abt Associates, Inc. 

652 “Memorandum to EPA, Nishkam Agarwal, ‘Actual and Potential Uses of Fourteen 

653 Selected Glymes,’” September 9, 2009. 

654 

655 2. US EPA TRI Website. http://www.epa.gov/ttn/atw/glycol2000.pdf 

656 

657 3. US EPA, Exposure Characterization for Ethylglyme, November 6, 2009.

658 

659 4. HSDB, 2008. Hazardous Substances Data Bank. Entry for diglyme. Accessed 

660 October 30, 2009. http://toxnet.nlm.nih.gov. 

661 

662 5. Hazardous Substances Data Bank (HSDB), http://toxnet.nlm.nih.gov. Entry for 

663 CASRN 112-36-7, Accessed on October 28, 2009. 

664 

665 6. Hazardous Substances Data Bank, http://toxnet.nlm.nih.gov. Entry for Ethylene 

666 glycol diethyl ether, CASRN 629-14-1. Accessed on October 30, 2009. 

667 

668 7. The Source Ranking Database is an EPA database that performs a systematic 

669 screening-level review of over 12,000 potential indoor pollution sources to identify high670 priority product and material categories for further evaluation. It can also identify the 

671 products that have contained a specific chemical. May, 1997. 

672 http://www.epa.gov/oppt/exposure/pubs/srd_apdx.pdf. 

673 8. US EPA, Screening-Level Exposure Characterization of High Production Volume 

Chemicals: 1,2-Dimethoxyethane (CAS No. 110-71-4), [9th 674 CI Name: Ethane, 1,2-

675 dimethoxy-], March 2008. 

676 

677 9. US EPA, Screening-Level Exposure Characterization of High Production Volume 

Chemicals: Diglyme (CAS No. 111-96-6), [9th 678 CI Name: Bis(2-methoxyethyl) Ether], 

679 March 2008. 

680 

681 10. US EPA, EETD/EAB. Physical-Chemical Properties and Fate Characterization: 

682 Glycol Ethers. August 2009. 

683 

684 11. Ferro Corporation. 1,2-Dimethoxyethane US EPA HPV Challenge Program 

685 Submission, December 2001, pages 7-8 of 93. 

686 
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687 12. US EPA. IUR database search results for number of workers exposed to ethylglyme, 

688 http://cfpub.epa.gov/iursearch/2006_iur_natlcheminfo.cfm?id=3975, accessed on October 

689 21, 2009. 

690 

691 13. US EPA, Screening-Level Hazard Characterization of High Production Volume 

Chemicals: 1,2-Dimethoxyethane (CAS No. 110-71-4), [9th 692 CI Name: Ethane, 1,2-

693 dimethoxy-], February 2008. 

694 

695 14. US EPA, Screening-Level Hazard Characterization of High Production Volume 

Chemicals: Diglyme (CAS No. 111-96-6), [9th 696 CI Name: Bis(2-methoxyethyl) Ether], 

697 February 2008. 

698 

699 15. US EPA. “2-ethoxyethanol, 2-ethoxyethanol acetate, 2-methoxyethanol, and 2-

700 methoxyethanol acetate; Significant New Use Rule.” 70 FR 71401, November 29, 2005. 

701 

702 16. US EPA 2010. Economic Analysis of the Proposed Significant New Use Rule for 14 

703 Glymes. Washington, DC: U.S. EPA/OPPT/EETD/EPAB, January 12, 2010. 

704 

705 XIII. Statutory and Executive Order Reviews 

706 A. Executive Order 12866: Regulatory Planning and Review 

707 

708 Under Executive Order 12866, entitled Regulatory Planning and Review (58 FR 51735, 

709 October 4, 1993), the Office of Management and Budget (OMB) has determined that this 

710 proposed SNUR is a ‘‘significant regulatory action,’’ because it meets the criteria in 

711 section 3(f) of the Executive Order. Accordingly, this action was submitted to the OMB 

712 for review under Executive Order 12866 and any changes made based on OMB 

713 recommendations have been documented in the public docket for this rulemaking as 

714 required by section 6(a)(3)(E) of the Executive Order. 

715 

716 B. Paperwork Reduction Act 

717 

718 According to the Paperwork Reduction Act (PRA), 44 U.S.C. 3501 et seq., an Agency 

719 may not conduct or sponsor, and a person is not required to respond to a collection of 

720 information that requires OMB approval under the PRA, unless it has been approved by 

721 OMB and displays a currently valid OMB control number. The OMB control numbers for 

722 EPA's regulations in Title 40 of the CFR, after appearing in the Federal Register, are 

723 listed in 40 CFR, part 9, and included on the related collection instrument, or form, if 

724 applicable. The information collection requirements related to this action have already 

725 been approved by OMB pursuant to the PRA under OMB control number 2070-0038 

726 (EPA ICR No. 1188). This action does not impose any burden requiring additional OMB 

727 approval. If an entity were to submit a SNUN to the Agency, the annual burden is 

728 estimated to average 110 hours per response. This burden estimate includes the time 

729 needed to review instructions, search existing data sources, gather and maintain the data 

730 needed, and complete, review, and submit the required SNUN. Send any comments 

731 about the accuracy of the burden estimate, and any suggested methods for minimizing 

732 respondent burden, including through the use of automated collection techniques, to the 
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733 Director, Collection Strategies Division, Office of Environmental Information (2822T), 

734 Environmental Protection Agency, 1200 Pennsylvania Ave., NW., Washington, D.C. 

735 20460-0001. Please remember to include the OMB control number in any 

736 correspondence, but do not submit any completed forms to this address. 

737 

738 C. Regulatory Flexibility Act 

739 

740 Pursuant to section 605(b) of the Regulatory Flexibility Act (RFA) (5 U.S.C. 601 et seq.), 

741 the Agency hereby certifies that promulgation of this SNUR would not have a significant 

742 adverse economic impact on a substantial number of small entities. The rationale 

743 supporting this conclusion is as follows. A SNUR applies to any person (including small 

744 or large entities) who intends to engage in any activity described in the rule as a 

745 “significant new use.” By definition of the word “new” and based on all information 

746 currently available to EPA, it appears that no small or large entities presently engage in 

747 such activity. Since this proposed SNUR would require a person who intends to engage 

748 in such activity in the future to first notify EPA by submitting a SNUN, no economic 

749 impact will occur unless someone files a SNUN to pursue a significant new use in the 

750 future or forgoes profits by avoiding or delaying the significant new use. Although some 

751 small entities may decide to conduct such activities in the future, EPA cannot presently 

752 determine how many, if any, there may be. However, EPA's experience to date is that, in 

753 response to the promulgation of over 1,000 SNURs, the Agency receives on average only 

754 5 notices per year. Of those SNUNs submitted, only one appears to be from a small entity 

755 in response to any SNUR. Therefore, EPA believes that the potential economic impact of 

756 complying with this SNUR is not expected to be significant or adversely impact a 

757 substantial number of small entities. In a SNUR that published as a final rule on August 

758 8, 1997 (62 FR 42690)(FRL-5735-4), the Agency presented its general determination that 

759 proposed and final SNURs are not expected to have a significant economic impact on a 

760 substantial number of small entities, which was provided to the Chief Counsel for 

761 Advocacy of the Small Business Administration. 

762 

763 D. Unfunded Mandates Reform Act 

764 

765 Based on EPA’s experience with proposing and finalizing SNURs, State, local, and 

766 Tribal governments have not been impacted by these rulemakings, and EPA does not 

767 have any reason to believe that any State, local, or Tribal government would be impacted 

768 by this rulemaking. As such, EPA has determined that this regulatory action would not 

769 impose any enforceable duty, contain any unfunded mandate, or otherwise have any 

770 effect on small governments subject to the requirements of sections 202, 203, 204, or 205 

771 of the Unfunded Mandates Reform Act of 1995 (UMRA) (Public Law 104-4). 

772 

773 E. Executive Order 13132: Federalism 

774 

775 This action would not have a substantial direct effect on States, on the relationship 

776 between the national government and the States, or on the distribution of power and 

777 responsibilities among the various levels of government, as specified in Executive Order 

778 13132, entitled Federalism (64 FR 43255, August 10, 1999). 
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779 

780 F. Executive Order 13175: Consultation and Coordination with Indian Tribal 

781 Governments 

782 

783 This proposed rule would not have Tribal implications because it is not expected to have 

784 substantial direct effects on Indian Tribes. This proposed rule would not significantly or 

785 uniquely affect the communities of Indian Tribal governments, nor would it involve or 

786 impose any requirements that affect Indian Tribes. Accordingly, the requirements of 

787 Executive Order 13175, entitled Consultation and Coordination with Indian Tribal 

788 Governments (65 FR 67249, November 9, 2000), do not apply to this proposed rule. 

789 

790 G. Executive Order 13045: Protection of Children from Environmental Health Risks and 

791 Safety Risks 

792 

793 This action is not subject to Executive Order 13045, entitled Protection of Children from 

794 Environmental Health Risks and Safety Risks (62 FR 19885, April 23, 1997), because this 

795 is not an economically significant regulatory action as defined by Executive Order 12866, 

796 and this action does not address environmental health or safety risks disproportionately 

797 affecting children. 

798 

799 H. Executive Order 13211: Actions that Significantly Affect Energy Supply, Distribution, 

800 or Use 

801 

802 This proposed rule is not subject to Executive Order 13211, entitled Actions Concerning 

803 Regulations That Significantly Affect Energy Supply, Distribution, or Use (66 FR 28355, 

804 May 22, 2001), because this action is not expected to affect energy supply, distribution, 

805 or use. 

806 

807 I. National Technology Transfer Advancement Act 

808 

809 Since this action does not involve any technical standards; section 12(d) of the National 

810 Technology Transfer and Advancement Act of 1995 (NTTAA), Public Law 104-113, 

811 section 12(d) (15 U.S.C. 272 note), does not apply to this action. 

812 

813 J. Executive Order 12898: Federal Actions to Address Environmental Justice in Minority 

814 Populations and Low-Income Populations 

815 

816 This action does not entail special considerations of environmental justice related issues 

817 as delineated by Executive Order 12898, entitled Federal Actions to Address 

818 Environmental Justice in Minority Populations and Low-Income Populations (59 FR 

819 7629, February 16, 1994). 

820 

821 

822 List of Subjects in 40 CFR Part 721

823 
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824 Environmental protection, Chemicals, Hazardous substances, Reporting and 

825 recordkeeping requirements.

826 

827 Dated: ________ 

828 

829 ________________ 

830 Click -- Insert Title will be OPPT/OD 

831 

832 

833 Therefore, it is proposed that 40 CFR chapter I be amended as follows: 

834 PART 721- [Amended] 

835 1. The authority citation for part 721 continues to read as follows: 

836 Authority: 15 U.S.C. 2604, 2607, and 2625(c). 

837 

838 2. By adding new § 721.xxxxx to subpart E to read as follows:

839 § 721.xxxxx Glymes. 

840 

841 (a) Chemical substances and significant new uses subject to reporting. (1) The 

842 chemical substances identified in Table 1 are subject to reporting under this section for 

843 the significant new uses described in Table 1, Column 3 “Significant New Use.” 

844 

845 Table 1 – Chemicals Subject to Reporting and Designated Significant New Uses 

846 

CAS Registry 

Number 

(CASRN) 

CA Index Name Significant New Use 

110-71-4 Ethane, 1,2-dimethoxy- Any use in a consumer 

product except in 

electrolyte solutions for 

sealed lithium batteries 

111-96-6 Ethane, 1,l'-oxybis[2-methoxy- Any use in a consumer 

product except as a 

solvent in printing inks 

for consumer products 

112-36-7 Ethane, 1,l'-oxybis[2-ethoxy- Any use in a consumer 

product 

112-49-2 2,5,8, 11-Tetraoxadodecane Any use in a consumer 

product except 

-as a solvent in consumer 

adhesives 

-as a component of 

consumer brake fluids 

-as a component of 
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consumer paint/graffiti 

removers 

-in consumer paints 

112-73-2 Butane, 1,1'-[oxybis(2,1-

ethanediyloxy)]bisAny use in a consumer product 

112-98-1 5,8,11,14,17-

Pentaoxaheneicosane 

Any use in a consumer 

product 

143-24-8 2,5,8,11,14-

Pentaoxapentadecane 

Any use in a consumer 

product except 

-as an HFC/CFC 

lubricant 

-as a solubilizing agent 

for consumer printing 

inks 

-as a coalescing agent in 

consumer paints 

629-14-1 Ethane, 1,2-diethoxy- Any use in a consumer 

product 

4353-28-0 3,6, 9, 12,15-

Pentaoxaheptadecane 

Any use in a consumer 

product 

23601-39-0 3, 6, 9, 12, 15, 18-

Hexaoxaeicosane 

Any use in a consumer 

product 

24991-55-7 Poly(oxy-l,2-ethanediyl), 

.alpha.-methyl-.omega.-

methoxyAny use in a consumer 

product except in 

consumer paint strippers 

31885-97-9 Poly(oxy-1,2-ethanediyl), 

.alpha.-butyl-.omega.-butoxyAny use in a consumer product 

51105-00-1 5,8,11,14,17,20-

Hexaoxatetracosane 

Any use 

63512-36-7 5,8,11,14-Tetraoxaoctadecane Any use 

847 

848 

849 [FR Doc. 09–????? Filed ??–??–09; 8:45 am] 

850 BILLING CODE 6560–50–S