EXHIBIT 10.46

  

  
    Confidential Materials omitted and filed separately with the

    Securities and Exchange Commission. Double asterisks denote omissions.

  

  

  

  
    	
            AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

          	
            1. CONTRACT ID CODE

                 

          	
            PAGE OF PAGES

          
	
            1

          	
            2

          
	
            2. AMENDMENT/MODIFICATION NO.

                0015

          	
            3. EFFECTIVE DATE

                12/07/2018

          	
            4. REQUISITION/PURCHASE REQ NO.

                See Schedule

          	
            5. PROJECT NO. (If
                  applicable)

                 

          
	
            6. ISSUED BY CODE

          	
            ASPR-BARDA

          	
            7. ADMINISTERED BY (If other than Item 6)    CODE

          	
            ASPR-BARDA02

          
	
            ASPR-BARDA

                200 Independence Ave., S.W.

                Room 640-G

                Washington DC 20201

          	
            US DEPT OF HEALTH & HUMAN SERVICES

                ASST SEC OF PREPAREDNESS & RESPONSE

                ACQ MANAGEMENT, CONTRACTS, & GRANTS

                O’NEILL HOUSE OFFICE BUILDING

                Washington DC 20515

          
	
            8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP
                  Code)

          	
            (x)

          	
            9A. AMENDMENT OF SOLICITATION NO.

          
	
            EMERGENT BIODEFENSE OPERATIONS LANSING LLC 330303

                Attn:  DIANA

                EMERGENT BIODEFENSE OPERATIONS LANS

                3500 N MARTIN LUTHER KING JR BLVD

                LANSING MI 489062933

          	 	 
	 	
            9B. DATED (SEE ITEM
                  11)

          
	 	 
	
            x

          	
            10A. MODIFICATION OF CONTRACT/ORDER NO.

          
	 	
            HHSD200201792634C

          
	 	
            10B. DATED (SEE ITEM
                  13)

          
	
            CODE    330303

          	
            FACILITY CODE

          	 	
            12/08/2016

          
	
            11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

          
	
             The above numbered solicitation is
                  amended as set forth in Item 14.  The hour and date specified for receipt of Offers is extended, is not extended.  Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended,
                  by one of the following methods: (a) By completing Items 8 and 15, and returning _________ copies of the amendment; (b) By acknowledging receipt of this amendment on each copy of the offer submitted; or

                (c) By separate letter or telegram which includes a reference to the solicitation and amendment numbers.  FAILURE OF YOUR ACKNOWLEDGMENT TO BE RECEIVED AT
                  THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER.  If by virtue of this amendment you desire to change an offer already submitted, such change may be made by
                  telegram or letter, provided each telegram or letter makes reference to the solicitation and this amendment, and is received prior to the opening hour and date specified.

          
	
            12. ACCOUNTING AND APPROPRIATION DATA (If required) Net Increase:$[**]

            2019.1990050.26402

          
	
            13. THIS ITEM APPLIES ONLY TO MODIFICATIONS OF
                CONTRACTS/ORDERS.

                IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

          
	
            CHECK ONE

          	
            A. THIS CHANGE ORDER IS ISSUED PURSUANT TO: (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.

          
	 
	 	
            B. THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE
                ADMINISTRATIVE CHANGES (such as changes in paying office, appropriation date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF
                FAR 43.103(b).

          
	 	
            C. THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:

            FAR 52.217-7 Option for Increased Quantity – Separately Priced Line Item

          
	 	
            D. OTHER (Specify type of modification and authority)

          
	
            E. IMPORTANT: 
                Contractor    is not, is required to sign this document and return ____1____ copies to the issuing office.

          
	
            14. DESCRIPTION OF
                  AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible.)

            Tax ID Number: 38-3412788

                DUNS Number: 026489018

                The purpose of this modification is to:

             

            1. Order an increased quantity of [**] doses of [**] product at a unit price of $[**] per dose for a total cost of
                $[**].

             

            2. Order an increased quantity of [**] doses of [**] product at a unit price of $[**] per dose for a total costs of
                $[**].

             

            3. Accordingly, total contract value is hereby increased from $[**] by Continued...

          
	
            Except as provided herein, all terms and conditions of the document referenced in Item 9A or 10A, as heretofore
                changed, remains unchanged and in full force and effect.

          
	
            15A. NAME AND TITLE OF SIGNER (Type or print)

                Michael Mann, Sr. Manager Comm. Ops.

          	
            16A. NAME AND TITLE OF CONTRACTING OFFICER (Type or print)

                Caleb W. Owen

          
	
            15B. CONTRACTOR/OFFEROR

             

             

            /s/ J. Michael Mann II 

            (Signature of person authorized to sign)

          	
            15C. DATE SIGNED

             

            02 JAN 19

          	
            16B. UNITED STATES OF AMERICA

            By

            Makoto P. Braxton – S

              

            (Signature of Contracting Officer)

          	
            16C. DATE SIGNED

          


    NSN 7540-01-152-8070 STANDARD FORM 30 (Rev. 10-83)

    Previous edition unusable Sponsored by GSA

    FAR (48 CFR) 53.243

    
      
        


    

    	

          	

          	 	
            PAGE OF

          	 
	
            CONTINUATION SHEET

          	
            REFERENCE NO. OF DOCUMENT BEING CONTINUED

            HHSD200201792634C/0015

          	 	 	
            2

          	 	 	 	
            2

          	 
	
            NAME OF OFFEROR OR CONTRACTOR

            EMERGENT BIODEFENSE OPERATIONS LANSING LLC 330303

          	 
	
            ITEM No.

                (A)

          	 	
            SUPPLIES/SERVICES

                (B)

          	
            QUANTITY

                (C)

          	
            UNIT

                (D)

          	 	
            UNIT PRICE

                (E)

          	 	 	
            AMOUNT

                (F)

          	 
	 	
            3

          	 	
            $[**] to $[**].

            Appr. Yr.: 2019 CAN: 1990050 Object Class: 26402

                FOB: Origin

                Period of Performance: 01/19/2017 to 09/30/2021

            Add Item 3 as follows:

            Optional Line Item 0003

            BioThrax [**] product

                [**] upon date of delivery:

                [**] at a unit price of $[**]

            Quantity: [**]

                Unit Price: $[**]

                Total Value: $[**]

            Delivery Address:  Contractor's  Facility

            Delivery is estimated to occur by NLT [**]

            [**] Product

                [**] at date of delivery:

                [**]

            Quantity: [**]

                Unit Price: $[**]

                Total Value: $[**]

            Delivery Address: Contractor's Facility

            Delivery is estimated to occur by NLT [**]

            Overall Total Order Price: [**]

            Obligated Amount: $[**]

                Requisition No: OS232936, OS233064

          	 	 	 	 	 	 	 	 	
            [

          	
            **]

          


    NSN 7540-01-152-8067 OPTIONAL FORM 336 (4-86)

    Sponsored by GSA

    FAR (48 CFR) 53.110