License Agreement



 EXHIBIT 10.5 
 EXECUTION COPY 
 UNC/MYRIAD LICENSE AGREEMENT 
 UNC/MYRIAD LICENSE AGREEMENT (this “Agreement”), effective as of January 20, 2009 (the “Effective Date”), between THE UNIVERSITY
OF NORTH CAROLINA AT CHAPEL HILL having an address at CB #4105, 308 Bynum Hall, Chapel Hill, NC (hereinafter referred to as “University”) and MYRIAD PHARMACEUTICALS, INC., a corporation organized and existing under the laws of Delaware and
having an address at 320 Wakara Way, Salt Lake City, Utah 84108 (together with its Affiliates, hereinafter referred to as “Licensee”). 
 WITNESSETH 
 WHEREAS, University owns and controls its share of the ownership interest in the inventions covered by the Patents
listed in Appendix A (hereinafter “Inventions”) hereto, developed jointly by University and Panacos Pharmaceuticals, Inc. (“Panacos”) pursuant to the Sponsored Research Agreement; and 
 WHEREAS substantially concurrently with the execution and delivery of this Agreement, (i) Licensee and Panacos are entering into, and effecting a
closing under, an Asset Purchase Agreement and related agreements whereby Panacos is assigning to Licensee Panacos’ share of the ownership interest in the Patents listed in Appendix A and (ii) the License Agreement effective as of
February 28, 2003 between University and Panacos, as amended (the “2003 UNC/Panacos License Agreement”) is being terminated and superseded in its entirety by a License Agreement dated the date hereof, whereby University is granting to
Panacos a worldwide license to certain patents, patent applications and technology (not including the Inventions) owned or controlled by University, upon the terms and subject to the conditions set forth therein; and 
 WHEREAS, Licensee is desirous of producing, using and selling products which include the use of Inventions and is willing to expend its commercially
reasonable efforts and resources to do so if it can obtain an exclusive license to use the Inventions under the terms and conditions set forth herein; and 
 WHEREAS, University desires to facilitate a timely transfer of its information and technology concerning the Inventions for the ultimate benefit of the public and this transfer is best accomplished by the grant of
this license; and 
 WHEREAS, in the opinion of the University, this transfer can best be accomplished consistent with its mission by
affiliation with Licensee; 
 NOW, THEREFORE, for and in consideration of the covenants, conditions, and undertakings hereinafter set forth,
it is agreed by and between the parties as follows: 
  

	I.	DEFINITIONS 

 1.1.
“UNIVERSITY TECHNOLOGY” means any unpublished (a) research and development information, (b) unpatented inventions, and (c) technical data, owned by or in the control of University prior to the
Effective Date or during the Term of 

  

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 Portions of this Exhibit were omitted and have been filed separately with the Secretary of the Commission pursuant to the Company’s application requesting confidential treatment under Rule 24b-2 of the Securities Exchange Act of 1934.









 
this Agreement, which relates to and is necessary for: (i) the practice of the Inventions, or (ii) the manufacture, use, sale, offer for sale or
importation of any compounds disclosed in the Patents or any analogs, derivatives, modifications or improvements thereof, and which University has the right to provide Licensee under this Agreement, and which Licensee does not otherwise own or
control. 
 1.2. “INVENTIONS” has the meaning set forth in the first Whereas clause above.

 1.3. “LICENSED PRODUCTS” means (i) any method, procedure, or component part
thereof whose manufacture, use, sale, offer for sale or importation is covered by any University Technology or by one or more Valid Claims of the Patents, or (ii) any product containing at least one Licensed Compound. 
 1.4. “LICENSED COMPOUNDS” means any individual compounds whose manufacture, use, sale, offer for
sale or importation is covered by any University Technology or by one or more Valid Claims of the Patents. 
 1.5.
“PATENTS” means any US patents and/or patent applications owned or controlled in whole or in part by University prior to or during the Term of this Agreement and which University has the right to provide its share to
Licensee and which are included in and limited to those listed in Appendix A attached hereto, as well as any continuations, continuations in part, divisionals, provisionals, continued prosecution applications, extensions, or reissues thereof, and
any foreign counterpart of any of the foregoing. 
 1.6. “NET SALES” means, subject to
Article 3.4, the invoiced sales price of Licensed Products sold by Licensee, less (a) any charges for sales taxes or other taxes separately stated on the invoice, (b) shipping and insurance charges, (c) actual credits and allowances
for returned, rejected, recalled, or defective goods, (d) trade discounts, but before cash discounts and (e) government mandated rebates. Licensed Products will be considered sold when billed out, or when delivered or paid for before
delivery, whichever first occurs. As used herein, “cash discounts” means discounts given on account of payments made in cash or payments made early. 
 1.7. “LICENSED TERRITORY” means the world, subject to any restrictions in Article XI herein.

 1.8. “LICENSED FIELD” means any and all human therapeutic and prophylactic uses.

 1.9. “SUBLICENSEE” means any person or organization to which Licensee has granted a sublicense to
the University Technology or Patents for the purpose of development and/or commercialization of Licensed Products in the Licensed Field. 
  

 2 
 Portions of this Exhibit were omitted and have been filed separately with the Secretary of the Commission pursuant to the Company’s application requesting confidential treatment under Rule 24b-2 of the Securities Exchange Act of 1934.









 1.10. “CONFIDENTIAL INFORMATION” means
information considered proprietary to the party disclosing the information, and may include information relating to: research, development, patent prosecution and maintenance, manufacturing, purchasing, accounting, engineering, marketing,
merchandising or selling. 
 1.11. “SUBLICENSE INCOME” means all royalties, all other
payments, and any equity Licensee receives from Sublicensees, of which University is owed a percentage; provided, however, that Sublicense Income shall specifically exclude (i) payments made in consideration for the issuance of equity or debt
securities of Licensee at fair market value (but shall specifically include any payments received by Licensee from the issuance of securities of Licensee to the extent such payments are in excess of fair market value), (ii) equity or debt
securities of a Sublicensee issued to Licensee if acquired by Licensee at fair market value, and (iii) payments specifically committed to research funding or development activities, or reimbursements of the same. In the event of a sublicense as
contemplated herein, such sublicense shall state explicitly the consideration provided in exchange for University Technology or Patents. 
 1.12. “IND” means an Investigational New Drug Application filed with the Food and Drug Administration for authorization to initiate human clinical trials in the United States, or any foreign equivalent
document for authorization to initiate human clinical trials outside the United States. 
 1.13.
“AFFILIATE” means any corporation or other business entity which, directly or indirectly, controls, is controlled by, or is under common control with, a party. For purposes of this definition, “control” means
ownership or beneficial interest in 40% or more of the voting stock or other voting interest of the corporation or other business entity. 
 1.14. “ANDA” means an Abbreviated New Drug Application, made in the form of a Food and Drug Administration submission or package to the Food and Drug Administration, for approval to market a
Licensed Product in the United States, or any foreign equivalent document for approval to market a Licensed Product outside the United States. 
 1.15. “FIRST COMMERCIAL SALE” means the first sale of Licensed Product for use in the Field by Licensee or its Sublicensee to any third party in a country.

 1.16. “NDA” means an original New Drug Application, made in the form of a Food and Drug
Administration submission or package to the Food and Drug Administration, for approval to market a Licensed Product in the United States, or any foreign equivalent document. 
 1.17. “PERFORMANCE MILESTONE” means any milestone listed on Appendix B attached hereto.

  

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 Portions of this Exhibit were omitted and have been filed separately with the Secretary of the Commission pursuant to the Company’s application requesting confidential treatment under Rule 24b-2 of the Securities Exchange Act of 1934.









 1.18. “PHASE II CLINICAL
TRIAL” means a dosing range trial to evaluate efficacy and safety in the targeted patient population and/or to define optimal dosing regimen of Licensed Product, or any other trial required to be designated as a Phase II clinical
trial by the Food and Drug Administration. 
 1.19. “ROYALTY QUARTER” has the meaning
set forth in Article 3.5. 
 1.20. “SPONSORED RESEARCH AGREEMENT” means
that certain sponsored research agreement by and between University and Panacos effective April 28, 1999, including any amendments thereto. 
 1.21. “TERM” shall commence on the Effective Date and shall expire upon the expiration of the last Valid Claim of the Patents, unless earlier terminated pursuant to Article VII. 
 1.22. “VALID CLAIM” means either (a) a claim of an issued and unexpired patent included
within the Patents which has not been held permanently revoked, unenforceable or invalid by a decision of a court or other governmental agency of competent jurisdiction, unappealable or unappealed within the time allowed for appeal, and which has
not been admitted to be invalid or unenforceable through reissue or disclaimer or otherwise or (b) a claim of a pending patent application included within the Patents, which claim was filed in good faith and has not been abandoned or finally
disallowed without the possibility of appeal or refiling of said application. Notwithstanding the foregoing (and subject to Article 3.3(iii)), if a claim of a pending patent application has not issued as a claim of an issued patent within ten
(10) years after the filing date from which such claim takes priority, such pending claim shall cease to be a Valid Claim for purposes of this Agreement unless and until such claim becomes an issued claim of an issued patent. 
 1.23. “PATENT COUNSEL” has the meaning set forth in Article 11.1. 
  

	II.	TERMINATION OF 2003 UNC/PANACOS LICENSE AGREEMENT; GRANT OF LICENSE; UNIVERSITY RESTRICTIONS 

 2.1. University hereby acknowledges, and confirms to Licensee, that the 2003 UNC/Panacos License Agreement has been terminated in its
entirety. 
 2.2. (i) University grants to Licensee, to the extent of the Licensed Territory, a non-exclusive right and
license (with the right to grant sublicenses pursuant to Article 2.3) to use University Technology in the Licensed Field, subject to all the terms and conditions of this Agreement. 
 (ii) University grants to Licensee, to the extent of the Licensed Territory, an exclusive right and license (with the right to grant
sublicenses pursuant to Article 2.3) under the Patents to make, have made, use, sell, offer for sale, and import Licensed Products and Licensed Compounds embodying the Invention(s) in the Licensed Field, upon the terms and conditions set forth
herein. 
  

 4 
 Portions of this Exhibit were omitted and have been filed separately with the Secretary of the Commission pursuant to the Company’s application requesting confidential treatment under Rule 24b-2 of the Securities Exchange Act of 1934.









 2.3. University grants to Licensee, to the extent of the Licensed Territory, the right to
sublicense. Sublicensees shall be subject to provisions substantially similar to the following provisions of this Agreement: Articles 2.5, 2.6, 2.7, 2.8, VI, IX, XIV, XV, XVI, XIX, XXI, and XXII and this Article 2.3. Sublicensees may not further
sublicense any rights they obtain herein without the written consent of University. In the event of early termination of this Agreement, any sublicense agreement with any Sublicensee shall provide for the termination of the sublicense, or the
conversion to a license directly between such Sublicensee and University on substantially the same terms as the sublicense agreement, at the option of the Sublicensee, provided, however, that in no event shall University have greater obligations to
such Sublicensee as it has to Licensee hereunder. 
 2.4. Any license granted herein (excluding the grant in Article 2.2(i)
above) is exclusive for the Term of this Agreement. 
 2.5. Licensee shall not disclose any University Technology pursuant to
Article 2.2(i) above to third parties during the Term or any time thereafter, provided, however, that disclosure of University Technology may be made at any time (1) with the prior written consent of University, or (2) pursuant to the
provisions of this Agreement, including Article 6 herein. 
 2.6. Licensee is further granted the right to disclose and use
any University Technology, or other Confidential Information of University pertaining to the Patents, Licensed Products, or Licensed Compounds in any submission to local, state, federal or foreign governmental agency, including, but not limited to,
the US Food and Drug Administration and the US Patent and Trademark Office, notwithstanding any provisions to the contrary in Article VI. 
 2.7. Notwithstanding the foregoing, any and all licenses granted hereunder are subject to the rights of the United States Government which may arise out of its sponsorship of the research which led to the Inventions.

 2.8. Subject to the licenses granted to Licensee pursuant to the foregoing provisions of this Article II, each party
retains all right, title, and interest in such party’s inventions and intellectual property, including, without limitation, its share of any joint inventions and jointly owned Patents. 
  

	III.	LICENSE FEE AND ROYALTIES 

 3.1. [RESERVED]

  

 5 
 Portions of this Exhibit were omitted and have been filed separately with the Secretary of the Commission pursuant to the Company’s application requesting confidential treatment under Rule 24b-2 of the Securities Exchange Act of 1934.









 3.2. The parties acknowledge that Panacos has paid University for all past costs
(including reasonable attorney’s fees) arising out of the filing, prosecution, or maintenance of the Patents. Licensee will pay a further license fee in the form of payment of future costs (including attorney’s fees) arising out of the
filing and prosecution of the Patents covering the Inventions pursuant to Article XI of this Agreement. Payment of such costs shall be non-refundable and shall not be a credit against any other amounts due hereunder. 
 3.3. (i) Beginning on the Effective Date of this Agreement and continuing, on a country-by-country basis, until the last to expire Valid
Claim of Patents covering such Licensed Products, Licensee will pay University a running patent royalty on all Net Sales of Licensed Products in the Licensed Field covered by a Valid Claim of the Patents, in accordance with the chart below:

  

				
	 NET SALES OF
 LICENSED PRODUCT(S)
	  	ROYALTY RATE	 
	 <$[***]
	  	[***]	%
	 >$[***]
	  	[***]	%

 (ii) During the Term of this Agreement, Licensee will pay University a running
technology royalty on all Net Sales of Licensed Products in the Licensed Field not covered by a Valid Claim of the Patents but whose manufacture, use, sale, offer for sale or importation is covered by University Technology, in accordance with the
chart below: 
  

				
	 NET SALES OF
 LICENSED PRODUCT(S)
	  	ROYALTY RATE	 
	 <$[***]
	  	[***]	%
	 >$[***]
	  	[***]	%

 (iii) In addition to the foregoing, the parties acknowledge and agree that in the
event a claim of a pending patent application ceases to be a Valid Claim pursuant to the last sentence of Article 1.22, and such pending patent application later issues during the Term of this Agreement, Licensee shall pay University the difference
between any patent royalties that would have been payable by Licensee under Article 3.3(i) if such claim of the pending patent application had not ceased to be a Valid Claim in the first instance pursuant to Article 1.22, and the technology royalty
actually paid pursuant to Article 3.3(ii). 
 3.4. (i) In the event any Licensed Product in the Licensed Field is a
combination of one or more Licensed Compounds with one or more other active ingredients not licensed hereunder, Net Sales for purposes of determining royalty payments on such combination shall be calculated by multiplying the net sales
(i.e., the invoiced sales price of the combination less the deductions set forth in Article 1.6) by the fraction A/(A+B) in which “A” is the total of the gross selling prices of the Licensed Compounds, and “B” is the
total of the gross selling prices of the other active ingredients. 
  

 6 
 Portions of this Exhibit were omitted and have been filed separately with the Secretary of the Commission pursuant to the Company’s application requesting confidential treatment under Rule 24b-2 of the Securities Exchange Act of 1934.









 (ii) In the event that it is not possible to determine the gross selling price for each
ingredient, Net Sales shall be calculated by multiplying the net sales (i.e., the invoiced sales price of the combination less the deductions set forth in Article 1.6) of the combination by the fraction C/(C+D), in which “C” is
the total of the direct costs plus the direct overhead of the Licensed Compounds and “D” that of the other active ingredients. The direct costs plus the direct overhead of a component shall be determined in accordance with generally
acceptable cost accounting principles. 
 3.5. Beginning with the date of First Commercial Sale of any Licensed Product in the
Licensed Field, Licensee agrees to make quarterly written reports to University within thirty (30) days after the first (1st) days of each January, April, July, and October during the Term of this Agreement and as of such dates, stating in
each such report the number, description, and aggregate Net Sales of Licensed Products sold, used, or otherwise disposed of during the preceding three calendar months (each such three calendar months a “Royalty Quarter”) and upon which a
royalty or percentage of Sublicense Income is payable as provided in Articles 3.3 or IV hereof, as appropriate. The first such report shall include all Net Sales of Licensed Products made prior to the date of such report. Until Licensee has achieved
the First Commercial Sale of Licensed Product, a report shall be submitted by Licensee at the end of each January after the Effective Date of this Agreement and will include a full written report summarizing Licensee’s technical and other
efforts made towards such First Commercial Sale of a Licensed Product. 
 3.6. In the event that it is necessary or required
for Licensee to make royalty or other payments to one or more third parties in order for Licensee or any Sublicensee to make, use, or sell Licensed Products, Licensee may offset a total of fifty percent (50%) of such third-party payments
against any royalty payments and/or percentage of Sublicense Income, as appropriate and in the Royalty Quarter they are due, that are otherwise due University hereunder, provided that in no event shall the royalty payments or percentage of
Sublicense Income otherwise due University be reduced by more than fifty percent (50%) in any Royalty Quarter. Notwithstanding the foregoing, in no event shall Licensee offset third-party payments against any royalty payments and/or percentage
of Sublicense Income that are otherwise due University hereunder if such third party payments relate solely to other active ingredients to which the combination Product calculations in Article 3.4 have been applied. 
 3.7. Concurrently with the making of each report pursuant to Article 3.5 above, Licensee shall pay to the University all payments due
University under Articles 3.3, 3.8 or IV, as appropriate. 
 3.8. Licensee will make milestone payments upon the first of
either Licensee or a Sublicensee reaching the designated stages of development listed in the table below, for each Licensed Product. Payment shall be the greater of the compensation due University pursuant to Article IV (if applicable), or the
amount listed in the table below. 
  

				
	 STAGE OF DEVELOPMENT
	  	MINIMUM
PAYMENT DUE
	 [***]
	  	$	[***]
	 [***]
	  	$	[***]

  

 7 
 Portions of this Exhibit were omitted and have been filed separately with the Secretary of the Commission pursuant to the Company’s application requesting confidential treatment under Rule 24b-2 of the Securities Exchange Act of 1934.









 For the avoidance of doubt, the parties acknowledge and agree that in no event shall Licensee owe
University payments under both this Article 3.8 and Article IV with respect to milestone payments received by Licensee from Sublicensees for the milestones listed hereunder. 
 In the event of default of any payment owing to University under the terms of this Agreement, and if it becomes necessary for University to undertake
legal action to collect said payment, Licensee shall pay all reasonable legal fees and costs incurred by University in connection therewith. 
 3.9. The parties recognize that different Licensed Products may contain the same Licensed Compound. However, the parties agree that only one milestone shall be payable pursuant to Section 3.8 or IV (as
applicable) for each individual Licensed Compound, regardless of the number of Licensed Products containing such Licensed Compound. For purposes of this Agreement, substitution of halogens, chalcogens, or differing lengths of a hydrocarbon backbone
shall not be considered distinct Licensed Compounds. 
 3.10. Nothing in this Agreement shall be construed to require the
payment of more than one royalty or percentage of Sublicense Income with regard to the Net Sale of an individual Licensed Product in the Licensed Field. No multiple royalties or percentages of Sublicense Income shall be payable because any Licensed
Product, or its manufacture, use, sale, offer for sale or importation is covered by more than one Valid Claim in a given country. 
  

	IV.	SUBLICENSES 

 In the case of income derived by Licensee
from Sublicensees, Licensee shall pay University a share of Sublicense Income, whose share shall be in accordance with the following table, on a Sublicensee by Sublicensee basis, subject to Article 3.8: 
  

				
	 STAGE OF DEVELOPMENT AT THE TIME OF EXECUTING A SUBLICENSE
 AGREEMENT WITH THE APPLICABLE SUBLICENSEE:
	  	% OF SUBLICENSE INCOME RECEIVED
FROM THE APPLICABLE
SUBLICENSEE PAYABLE TO
UNIVERSITY:	 
	 [***]
	  	[***]	%

  

 8 
 Portions of this Exhibit were omitted and have been filed separately with the Secretary of the Commission pursuant to the Company’s application requesting confidential treatment under Rule 24b-2 of the Securities Exchange Act of 1934.










	V.	COMMERCIALLY REASONABLE EFFORTS 

 5.1.
Licensee shall use commercially reasonable efforts to proceed diligently with the development, manufacture and sale of at least one (1) Licensed Product either directly or through a Sublicensee, and shall earnestly and diligently offer and
continue to offer for sale upon NDA approval, at least one (1) Licensed Product under reasonable conditions during the Term of this Agreement either directly or through a Sublicensee. 
 In particular, Licensee or its Sublicensee(s) will use commercially reasonable efforts to meet the Performance Milestones, which such achievement shall be
conclusive evidence that Licensee has used commercially reasonable efforts as required in the preceding paragraph. In the event that Licensee fails to meet a particular Performance Milestone during the timeframe set forth in Appendix B, University
shall have the right to terminate the licenses granted hereunder to University’s rights, upon thirty (30) days advance written notice to Licensee, unless Licensee either (i) cures such breach within such thirty (30) day period,
or (ii) elects to extend the Performance Milestone deadline pursuant to the provisions of Section 5.2 below. 
 5.2.
Licensee may have an additional twelve (12) months to reach a Performance Milestone upon payment of $[***] to University. In such an event, the timeframes set forth in Appendix B shall be extended by twelve (12) months. Licensee may obtain
as many extensions as necessary to achieve the Performance Milestones. 
  

	VI.	DISCLOSURE AND CONFIDENTIALITY 

 6.1.
Confidential Information disclosed by one party (“Disclosing Party”) to the other party (“Receiving Party”) may be oral or in writing, provided that any information disclosed orally shall be reduced to writing within thirty
(30) days of disclosure and all such information shall be clearly marked “CONFIDENTIAL” on the first page of such written disclosure. 
 6.2. Receiving Party agrees that all Confidential Information received under this Agreement or the Original Agreement shall be maintained in confidence during the Term and for a period of five (5) years from the
expiration or termination date of this Agreement and further agrees not to use such Confidential Information for any purpose other than fulfilling the purposes and upholding the obligations of this Agreement without the prior written consent of
Disclosing Party. Receiving Party shall use the same standard of care to protect the confidentiality of Confidential Information received under this Agreement as it uses to protect its own Confidential Information, and shall limit disclosure of
Disclosing Party’s Confidential Information to those of its employees, agents, consultants, investors and potential investors, Sublicensees, potential sublicensees and collaborators who have an actual need to know such information and who have
a written obligation, or are subject to applicable University policies, to protect the confidentiality of such Confidential Information which is at least as protective of such information as the agreement contained herein. 
  

 9 
 Portions of this Exhibit were omitted and have been filed separately with the Secretary of the Commission pursuant to the Company’s application requesting confidential treatment under Rule 24b-2 of the Securities Exchange Act of 1934.









 6.3. Notwithstanding Articles 2 or 6.2, the obligations of the Receiving Party regarding
confidentiality and use of University Technology or Confidential Information disclosed hereunder shall not include: 
 (i)
information which, at the time of disclosure, was published, known publicly, or otherwise in the public domain; 
 (ii)
information which, after disclosure, is published, becomes known publicly, or otherwise becomes part of the public domain through no fault of the Receiving Party; 
 (iii) information which the Receiving Party can establish was in its possession prior to the time of disclosure; 
 (iv) information which, after disclosure, is made available to Receiving Party in good faith by a third party under no obligation of
confidentiality to the Disclosing Party; or information which either party is required to disclose to comply with applicable laws or regulations, or with a court or administrative order, provided that the Disclosing Party receives prior written
notice of such disclosure and that the Receiving Party takes all reasonable and lawful actions to obtain confidential treatment for such disclosure and, if possible, to minimize the extent of such disclose. 
  

	VII.	CANCELLATION OR TERMINATION 

 7.1. It is
expressly agreed that, if Licensee should fail to deliver to University any payment, royalty, or equity at the time or times that the same should be due to University or if Licensee should in any material respect violate or fail to keep or perform
any covenant, condition, or undertaking of this Agreement on its part to be kept or performed hereunder (but specifically excluding any diligence obligations under Article V), then the University, by written notice to Licensee, shall have the right
to terminate this Agreement, provided, however, that Licensee shall have the opportunity to cure any such breach described in University’s written notice within thirty (30) days of receipt. Licensee’s right to cure a breach after the
first two breaches of Licensee properly noticed by University under the terms of this Agreement (regardless of the nature of those breaches) shall be conditioned upon Licensee paying the reasonable costs and expenses of University directly relating
to such breach by Licensee. If University should in any material respect violate or fail to keep or perform any material covenant, condition, or undertaking of this Agreement on its part to be kept or performed hereunder, then Licensee, by written
notice to University, shall have the right to terminate this Agreement, provided, however, that University shall have the opportunity to cure any such breach described in Licensee’s notice within thirty (30) days of receipt. 
 7.2. University may terminate this Agreement for Licensee’s lack of diligence, pursuant to the provisions of Articles 5.1 or 5.2 of
this Agreement, as the case may be. 
  

 10 
 Portions of this Exhibit were omitted and have been filed separately with the Secretary of the Commission pursuant to the Company’s application requesting confidential treatment under Rule 24b-2 of the Securities Exchange Act of 1934.









 7.3. If Licensee should be adjudged bankrupt or enter into a composition with or
assignment to its creditors, then in such event University shall have the right to cancel and terminate this Agreement, and the license herein provided for, by written notice to Licensee. 
 7.4. Any termination or cancellation under any provision of this Agreement shall not relieve either party of any obligation which accrued
prior to the effective date of such termination, including, in the case of Licensee, its obligation to pay any royalty or other fees (including attorney’s fees pursuant to Article 3.2 hereof) due or owing at the time of such cancellation or
termination. 
 7.5. Licensee may terminate this Agreement at any time by providing University with thirty (30) days
advance written notice. 
  

	VIII.	RIGHTS UPON CANCELLATION OR TERMINATION 

 The parties
acknowledge and agree that upon the termination or expiration of this Agreement for any reason: (i) each party retains all right, title, and interest in such party’s inventions and intellectual property, including, without limitation, its
share of any joint inventions and jointly owned Patents, and (ii) both parties may commercially exploit any joint inventions and jointly owned Patents in any and all countries without any further accounting to each other. 
  

	IX.	USE OF OTHER PARTY’S NAME 

 The use of the name of
either party by the other party, or any contraction thereof, in any manner in connection with this license is expressly prohibited except with the prior written consent of such party. 
  

	X.	UNIVERSITY USE 

 It is expressly agreed that,
notwithstanding any other provisions herein, University is free to use University Technology, Patents and Licensed Compounds for its own non-commercial research, and clinical, teaching and educational purposes (including distribution of any
compounds covered under the Patents to academic collaborators provided that the academic collaborators receiving Licensed Compounds shall be obligated to not transfer the Licensed Compounds to third party commercial entities and to not use the
Licensed Compounds in research sponsored by third party commercial entities) without payment of royalties. In no event shall University transfer the Patents or Licensed Compounds for sale or other distribution to third parties other than non-profit
research or educational institutions, or to such institutions in contravention of the foregoing provisions. Furthermore, except as otherwise set forth in the Sponsored Research Agreement, University shall be free to publish University Technology as
it sees fit. Notwithstanding the foregoing, in no event shall University use, or grant any third party a right to use, any Patents and/or Licensed Compounds in the Licensed Field for commercial purposes during the Term, including, without
limitation, conducting sponsored research with any for-profit entity during the Term. 
  

 11 
 Portions of this Exhibit were omitted and have been filed separately with the Secretary of the Commission pursuant to the Company’s application requesting confidential treatment under Rule 24b-2 of the Securities Exchange Act of 1934.










	XI.	PATENTS 

 11.1. Licensee shall bear the
cost of preparing, filing, prosecuting, and maintaining all United States and foreign patent applications and issued patents included within the Patents, and any interferences related to the Patents, at its sole cost and expense. Such preparation,
filing, prosecution, and maintenance shall be by patent counsel mutually agreeable to both Parties (“Patent Counsel”). As of the Effective Date, Patent Counsel has been designated as Myriad Pharmaceuticals, Inc. Patents claiming joint
inventions (as determined by inventorship under U.S. patent laws) shall be filed in the name of University and Licensee. Patent Counsel will keep University and Licensee advised of the prosecution of such Patents by forwarding copies of all official
correspondence, (including, but not limited to, applications, office actions, responses, etc.) relating thereto to University and Licensee. 
 11.2. University will provide Patent Counsel and Licensee, in a timely manner, all information in its possession or control which is subject to the terms and conditions of this Agreement necessary or useful for the
preparation, filing and maintenance of the Patents. University agrees to cooperate with Licensee and Patent Counsel to whatever extent is reasonable and necessary to prepare, file, prosecute, and maintain the Patents, including agreeing to execute
any and all documents to provide Licensee the benefits of the licenses granted herein. 
 11.3. If the production, sale or use
of Licensed Products under this Agreement by Licensee results in any claim for patent infringement against Licensee, Licensee shall promptly notify the University thereof in writing, setting forth the facts of such claim in reasonable detail. As
between the parties to this Agreement, Licensee shall have the first and primary right and responsibility, at its own expense, to defend and control the defense of any such claim against Licensee or its Sublicensees, by counsel of its own choice. It
is understood that any settlement of such actions which will have a material adverse effect on the rights of University hereunder must be approved by University. Such approval shall not be unreasonably withheld. University agrees to cooperate with
Licensee in any reasonable manner deemed by Licensee to be necessary in defending any such action. Licensee shall reimburse University for any out of pocket expenses incurred in providing such assistance. 
 11.4. In the event that any Patents are infringed or appear to be infringed by a third party, Licensee shall have the primary right, but
not the obligation, to institute, prosecute and control any action or proceeding with respect to such infringement, by counsel of its choice, including any declaratory judgment action arising from such infringement or apparent infringement.

  

 12 
 Portions of this Exhibit were omitted and have been filed separately with the Secretary of the Commission pursuant to the Company’s application requesting confidential treatment under Rule 24b-2 of the Securities Exchange Act of 1934.









 11.5. Notwithstanding the foregoing, and in University’s sole discretion, University
shall be entitled to participate, through counsel of its own choosing and at its sole cost and expense, in any legal action described in Articles 11.3 and 11.4 involving the Inventions, provided that Licensee shall retain the right to control such
actions unless Licensee has previously abandoned or elected not to proceed with such legal action. Nothing in the foregoing sections shall be construed in any way which would limit the authority of the Attorney General of North Carolina. 

 

	XII.	REPRESENTATIONS, WARRANTIES AND COVENANTS; WAIVER 

 12.1. The University represents, and covenants as follows: 
 (i) It has the full right, power, and authority to
enter into this Agreement and to perform all of its obligations hereunder. 
 (ii) The execution and delivery of this
Agreement and the consummation of the transaction contemplated by this Agreement do not violate, conflict with, or constitute a default under the University’s Charter or the terms and provisions of any agreement or other instrument to which the
University is a party or by which it is bound, or any material order, award, judgment or decree to which the University is a party or by which it is bound, or any state or federal law governing University activities. 
 (iii) Upon execution and delivery, this Agreement will constitute the legal, valid and binding obligation of the University enforceable
against the University in accordance with its terms. 
 (iv) Subject to the rights held by the U.S. Government under Public
Law 96-517, as amended, and the implementing regulations, and to such rights as may be held by Licensee, the University is the owner of all rights to the University Technology, and its share of the title and interest in Patents and Licensed
Compounds. Also subject to the aforementioned rights of the U.S. Government, the University has the sole and complete authority to issue and grant to Licensee the exclusive license granted hereunder, free and clear of any claims, liens, encumbrances
or charges of any third party. 
 (v) As of the Effective Date of this Agreement, the University has no knowledge of any
potential infringement action or claim relating to the University Technology, Patents, Licensed Compounds and Licensed Products and has no knowledge of any infringement, or breach of any agreement or of any facts that might reasonably lead to any
claim of infringement or breach of any agreement relating to any patent, patent right, patentable invention, patent application, trade secret or other proprietary right of any third party relating to the University’s use or ownership of the
University Technology, Patents, or Licensed Compounds, or Licensee’s licenses to the University Technology, Patents, or Licensed Compounds. However, University has done no searching regarding possible or potential infringement actions or
claims. 
 12.2. To the extent that rights granted by the University to Licensee under this Agreement are subject to the
requirements of Public Law 96-517, as amended, and its implementing regulations, the University agrees that it will take all steps within its power to retain title, to the fullest extent permitted by law, to the University Technology and its share
of the title to the Patents and Licensed Compounds in the United States and in any foreign country designated by Licensee for the duration of this license. 
  

 13 
 Portions of this Exhibit were omitted and have been filed separately with the Secretary of the Commission pursuant to the Company’s application requesting confidential treatment under Rule 24b-2 of the Securities Exchange Act of 1934.









 12.3. The University represents that it will promptly disclose, and cause its inventors
to disclose, to the designated Patent Counsel of Licensee all information which is or could be material to the patentability, enforceability or validity of any application or patent included in University Technology, Patents, Licensed Compounds,
and/or Licensed Products. 
 12.4. It is agreed that no waiver by either party hereto of any breach or default of any of the
covenants or agreements herein set forth shall be deemed a waiver as to any subsequent and/or similar breach or default. 
 12.5. To the knowledge of the University’s Office of Technology Development after reasonable inquiry, there is no research and development information, unpatented inventions, technical data, patent applications, or patents owned by or
in the control of University which relate to and are necessary for the manufacture, use, sale, offer for sale or importation of 3-O-(3’,3’-dimethylsuccinyl) betulinic acid, salts thereof, and polymorphs thereof that is not included in
the University Technology, Patents, Licensed Compounds or Licensed Products. 
  

	XIII.	LICENSE RESTRICTIONS 

 It is agreed that, as set forth in
and subject to Articles 7.1 and 7.2, the rights and privileges granted to Licensee are each and all expressly conditioned upon the faithful performance on the part of the Licensee of every requirement herein contained, and that each of such
conditions and requirements may be and the same are specific license restrictions. 
  

	XIV.	ASSIGNMENTS 

 This Agreement is binding upon and shall
inure to the benefit of the parties and their successors and permitted assigns. This Agreement may not be assigned or otherwise transferred by Licensee to any entity without the written consent of University, which consent shall not be unreasonably
withheld; provided, however, that Licensee, without such consent, may assign its rights and obligations under this Agreement in connection with a merger, consolidation, or sale of substantially all of Licensee’s assets. 
  

 14 
 Portions of this Exhibit were omitted and have been filed separately with the Secretary of the Commission pursuant to the Company’s application requesting confidential treatment under Rule 24b-2 of the Securities Exchange Act of 1934.










	XV.	INDEMNITY 

 15.1. Licensee agrees to
indemnify, hold harmless and defend University, its officers, employees, and agents (the “Indemnitees”), against any and all claims, suits, losses, damage, costs, fees, and expenses asserted by third parties, both government and private
(collectively, “Claims”), resulting from or arising out of the exercise of this license provided, however, that such indemnification shall not apply to any Claims to the extent directly attributable to (i) the negligent activities or
intentional misconduct of any Indemnitee or (ii) the settlement of a claim, suit, action, or demand by the Indemnitees without the prior written approval of Licensee. 
 15.2. Any Indemnitee seeking indemnification hereunder shall provide Licensee with prompt written notice of any Claim for which
indemnification is sought under this Agreement. Licensee agrees, at its own expense, to provide attorneys reasonably acceptable to the Indemnitee(s) to defend against any such Claim. The Indemnitee seeking indemnification hereunder shall cooperate
fully with Licensee in such defense and will permit Licensee to conduct and control such defense and the disposition of such Claim (including all decisions relative to litigation, appeal, and settlement); provided, however, that such Indemnitee
shall have the right to retain its own counsel reasonably acceptable to Licensee, at the expense of Licensee, if representation of such Indemnitee by the counsel retained by Licensee would be inappropriate because of actual or potential differences
in the interests of such Indemnitee and any other party represented by such counsel. Nothing herein should be construed to abrogate the authority of the Attorney General of the State of North Carolina. 
  

	XVI.	INSURANCE 

 Prior to initiating clinical trials, Licensee
shall obtain, at its sole cost and expense, with reputable insurance companies, general liability insurance and products liability insurance coverage in an amount reasonably sufficient to protect against liability under Article XV, above. The
University shall have the right to ascertain from time to time that such coverage exists. 
  

	XVII.	INDEPENDENT CONTRACTOR STATUS 

 Neither party hereto is an
agent of the other for any purpose. 
  

 15 
 Portions of this Exhibit were omitted and have been filed separately with the Secretary of the Commission pursuant to the Company’s application requesting confidential treatment under Rule 24b-2 of the Securities Exchange Act of 1934.









 XVIII. LATE PAYMENTS 
 In the event that any payment due hereunder is not made when due, the payment shall accrue interest
beginning on the tenth (10th) day following the due date thereof, calculated at the annual rate of the sum of (a) two and one-half percent
(2.5%) plus (b) the prime interest rate quoted by The Wall Street Journal on the date said payment was due. The interest shall be compounded on the last day of each calendar quarter provided, however, that in no event shall said annual
interest rate exceed the maximum legal interest rate for corporations. Each such royalty payment, when paid, shall be accompanied by all accrued interest. 
 XIX. WARRANTY DISCLAIMER 
 University makes no warranties that any patent will issue on University Technology or patent applications
within the Patents. University further makes no warranties, express or implied, as to any matter whatsoever, including, without limitation, the condition of any Inventions, Patents, Licensed Compounds or Licensed Products that are the subject of
this Agreement; or the merchantability or fitness for a particular purpose of any such Inventions, Licensed Compounds or Licensed Products. University shall not be liable for any direct, consequential, or other damages suffered by Licensee or any
others resulting from the use of the Licensed Compounds, Licensed Products, or Patents. 
  

	XX.	ACCOUNTING AND RECORDS 

 20.1. Licensee
will keep complete, true and accurate books of account and records for the purpose of showing the derivation of all amounts payable to University under this Agreement. Such books and records will be kept at Licensee’s principal place of
business for at least three (3) years following the end of the calendar quarter to which they pertain, and will be open at all reasonable times for inspection by an independent accounting firm reasonably acceptable to Licensee for the purpose
of verifying Licensee’s royalty statements, or Licensee’s compliance in other respects with this Agreement. Such accountant shall disclose to the University only information relating to the accuracy of the records kept and the payments
made, and shall be under a duty to keep confidential any other information obtained from such accounts and records. 
 20.2.
Such inspections shall be at the expense of University, unless a variation or error resulting from an underpayment to University exceeding the lesser of (i) US $5,000, or (ii) 1% for any consecutive twelve (12) month period is
discovered in the course of any such inspection, whereupon all costs relating thereto would be paid by Licensee. 
 20.3.
Licensee will promptly pay to University the full amount of any underpayment, along with interest calculated at the annual rate of the sum of (a) two and one-half percent (2.5%) plus (b) the prime interest rate quoted by The Wall
Street Journal on the date said payment was due. The interest shall be compounded on the last day of each calendar quarter provided, however, that in no event shall said annual interest rate exceed the maximum legal interest rate for corporations.

  

 16 
 Portions of this Exhibit were omitted and have been filed separately with the Secretary of the Commission pursuant to the Company’s application requesting confidential treatment under Rule 24b-2 of the Securities Exchange Act of 1934.










	XXI.	COMPLIANCE WITH LAWS 

 In exercising its rights under this
license, Licensee shall fully comply with the requirements of any and all applicable laws, regulations, rules and orders of any governmental body having jurisdiction over the exercise of rights under this license. Licensee further agrees to
indemnify and hold University harmless from and against any Claims which might be imposed by reason of any asserted or established violation of any such laws, order, rules, and/or regulations, pursuant to the provisions of Article XV. 
  

	XXII.	US MANUFACTURE 

 It is agreed that any Licensed Products
sold in the United States shall be substantially manufactured in the United States to the extent required by Public Law 96-517, as amended, and the implementing regulations. 
  

	XXIII.	NOTICES 

 Any notice required or permitted to be given to
the parties hereto shall be deemed to have been properly given if delivered in person or mailed by first-class certified mail to the other party at the appropriate address as set forth below or to such other addresses as may be designated in writing
by the parties from time to time during the Term of this Agreement. 
  

			
	 UNIVERSITY
	  	 LICENSEE

		
	 Director
 Office of Technology Development
 The University of North Carolina at Chapel Hill
 CB #4105, 308 Bynum Hall
 Chapel Hill, NC 27599-4105
	  	 Myriad Pharmaceuticals, Inc.
 320 Wakara
Way
 Salt Lake City, Utah 84108
 Attention: General
Counsel
 Phone: 801-833-3378
 Facsimile:
801-584-3640


  

	XXIV.	GOVERNING LAW 

 This Agreement shall be interpreted and
construed in accordance with the laws of the State of North Carolina. 
  

 17 
 Portions of this Exhibit were omitted and have been filed separately with the Secretary of the Commission pursuant to the Company’s application requesting confidential treatment under Rule 24b-2 of the Securities Exchange Act of 1934.










	XXV.	COMPLETE AGREEMENT 

 It is understood and agreed between
University and Licensee that this Agreement, together with the Appendixes constitutes the entire agreement, both written and oral, between the parties respecting the subject matter hereof, and that all prior agreements respecting the subject matter
hereof (including, without limitation, the Original Agreement pursuant to Article II), either written or oral, expressed or implied, shall be abrogated, cancelled, and are null and void and of no effect. 
  

	XXVI.	SEVERABILITY 

 In the event that a court of competent
jurisdiction holds any provision of this Agreement to be invalid, such holding shall have no effect on the remaining provisions of this Agreement, and they shall continue in full force and effect. 
  

	XXVII.	SURVIVAL OF TERMS 

 The provisions of Articles III and IV
(in each case, with respect to payment obligations accruing prior to the date of expiration or termination), 2.5, VI, 7.4, VIII, IX, XII, XV, XVI, XVII, XVIII (with respect to payment obligations accruing prior to the date of expiration or
termination), XIX, XX (with respect to payment obligations accruing prior to the date of expiration or termination), XXI, XXIII, XXIV and this Article XXVII shall survive the expiration or termination of this Agreement. 
 [The remainder of this page is intentionally left blank.] 
  

 18 
 Portions of this Exhibit were omitted and have been filed separately with the Secretary of the Commission pursuant to the Company’s application requesting confidential treatment under Rule 24b-2 of the Securities Exchange Act of 1934.









 IN WITNESS WHEREOF, both University and Licensee have executed this Agreement, in duplicate originals, by their
respective officers hereunto duly authorized, the day and year of last signature below. 
  

					
	 THE UNIVERSITY OF NORTH CAROLINA
 AT CHAPEL HILL
	 		 	MYRIAD PHARMACEUTICALS, INC.
			
	/s/ Cathy Innes	 		 	/s/ Adrian N. Hobden
	Cathy Innes	 		 	Name: Adrian N. Hobden
	Director	 		 	Title:   President

  

 19 
 Portions of this Exhibit were omitted and have been filed separately with the Secretary of the Commission pursuant to the Company’s application requesting confidential treatment under Rule 24b-2 of the Securities Exchange Act of 1934.









 Appendix A 
 Patents

 Betulinic Acid and Dihydrobetulinic Acid Derivatives and Use Therefor 
  

	1.	U.S. Patent No. 5,679,828 

 (from 08/463,071;
filed: June 5, 1995) 
 Inventors: Louis Mark Cosentino, Kuo-Hsiung Lee, Mark Manak, Yoshiki 
                  Kashiwada and Hashimoto Fumio 
 Issued: October 21, 1997 
 SKG&F
Ref.: 1900.0040000 
 Patented. Jointly owned by Myriad and UNC. 
  

	2.	International Patent Appl. No. PCT/US96/09485 

 (Corres.
to U.S. Appl. No. 08/463,071) 
 Inventors: Louis Mark Cosentino, Kuo-Hsiung Lee, Mark Manak, Yoshiki 
                  Kashiwada and Hashimoto Fumio 
 Filed: June 5, 1996 
 SKG&F Ref.:
1900.004PC00 
 Inactive. Entered National Phase in Canada and Europe. Jointly owned by Myriad and UNC. 
  

	3.	Canadian Patent Appl. No. 2,223,513 

 (National
Phase of PCT/US96/09485) 
 Inventors: Louis Mark Cosentino, Kuo-Hsiung Lee, Mark Manak, Yoshiki 
                  Kashiwada and Hashimoto Fumio 
 Filed: June 5, 1996 
 SKG&F Ref.:
1900.004CA00 
 Pending. Jointly owned by Myriad and UNC. 
  

	4.	European Patent Appl. No. 96922408.8 

 (National
Phase of PCT/US86/US0948) 
 Inventors: Louis Mark Cosentino, Kuo-Hsiung Lee, Mark Manak, Yoshiki 
                  Kashiwada and Hashimoto Fumio 
 Filed: June 6, 1996 
 SKG&F Ref.:
1900.004EP00 
 Pending. Jointly owned by Myriad and UNC.  
  

 20 
 Portions of this Exhibit were omitted and have been filed separately with the Secretary of the Commission pursuant to the Company’s application requesting confidential treatment under Rule 24b-2 of the Securities Exchange Act of 1934.









 Appendix B- 
 Performance
Milestones 
  

			
	 MILESTONE
	  	TIMEFRAME
	 [***]
	  	[***]
	 [***]
	  	[***]

  

 21 
 Portions of this Exhibit were omitted and have been filed separately with the Secretary of the Commission pursuant to the Company’s application requesting confidential treatment under Rule 24b-2 of the Securities Exchange Act of 1934.