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| R      | ANNUAL REPORT PURSUANT TO      SECTION 13 OR 15(d) OF THE SECURITIES   EXCHANGE ACT OF      1934                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         |
|--------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    |
|   | For      the fiscal year ended December 31, 2009                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        |
| or     |
|   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    |
| £ | TRANSITION REPORT PURSUANT TO      SECTION 13 OR 15(d) OF SECURITIESEXCHANGE ACT OF      1934                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           |
|   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    |
|   | For      the transition period from                                                                      to                                                                           |

| Delaware                                      | 58-1642740               |
|-----------------------------------------------|--------------------------|
| (State      or other jurisdiction of          | (I.R.S.      Employer    |
| incorporation      or organization)           | Identification      No.) |
|                                          |                     |
| 11726      San Vicente Blvd, Suite 650,       |                     |
| Los      Angeles, California                  | 90049                    |
| (Address      of principal executive offices) | (Zip      Code)          |

| Title of each class                                                |   | Name of exchange on which      registered |
|--------------------------------------------------------------------|--------|-------------------------------------------|
| Common      Stock, $0.001 par value per share                      |   | The      NASDAQ Capital Market            |
| Series      A Junior Participating Preferred Stock Purchase Rights |   |                                      |

| Large      accelerated filer £ | Accelerated      filer R | Non-accelerated      filer £                  | Smaller      reporting company £ |
|-------------------------------------|--------------------------|----------------------------------------------------|---------------------------------------|
|                                |                     | (Do      not check if a smaller reporting company) |                                  |

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|                                             | CYTRX      CORPORATION |                                       |
|--------------------------------------------------|------------------------|--------------------------------------------|
|                                             |                   |                                       |   |
|     Date:      July 16, 2010 | By:                    | /s/ STEVEN      A. KRIEGSMAN          |   |
|                                             |                   | Steven      A. Kriegsman                   |   |
|                                             |                   | President      and Chief Executive Officer |   |
|                                             |                   |                                       |   |

| Signature                                                                                                                                                                                                                                                                                                                                                        | Title                                                               | Date                     |
|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|---------------------------------------------------------------------|--------------------------|
|                                                                                                                                                                                                                                                                                                                                                             |                                                                |                     |
| /s/ STEVEN A.      KRIEGSMAN                                                       | Director,      President and Chief Executive Officer                | July      16, 2010       |
| Steven      A. Kriegsman                                                                                                                                                                                                                                                                                                                                         | (Principal      Executive Officer)                                  |                     |
|                                                                                                                                                                                                                                                                                                                                                             |                                                                |                     |
|  /s/      JOHN Y. CALOZ                                                                                                                                                                                                                                                                                                                                     | Chief      Financial Officer                                   |  July      16, 2010 |
| John      Y. Caloz                                                                                                                                                                                                                                                                                                                                               | (Principal      Financial Officer and Principal Accounting Officer) |                     |
|                                                                                                                                                                                                                                                                                                                                                             |                                                                |                     |
| /s/ MAX      LINK                                                                                                          | Chairman      of the Board                                          | July      16, 2010       |
| Max      Link, Ph.D.                                                                                                                                                                                                                                                                                                                                             |                                                                |                     |
|                                                                                                                                                                                                                                                                                                                                                             |                                                                |                     |
| /s/ MARVIN R.      SELTER                                                                                                  | Vice-Chairman      of the Board                                     | July      16, 2010       |
| Marvin      R. Selter                                                                                                                                                                                                                                                                                                                                            |                                                                |                     |
|                                                                                                                                                                                                                                                                                                                                                             |                                                                |                     |
| /s/ LOUIS      IGNARRO                                                                                                     | Director                                                            | July      16, 2010       |
| Louis      Ignarro, Ph.D.                                                                                                                                                                                                                                                                                                                                        |                                                                |                     |
|                                                                                                                                                                                                                                                                                                                                                             |                                                                |                     |
| /s/ JOSEPH      RUBINFELD                                                                                                  | Director                                                            | July      16, 2010       |
| Joseph      Rubinfeld, Ph.D.                                                                                                                                                                                                                                                                                                                                     |                                                                |                     |
|                                                                                                                                                                                                                                                                                                                                                             |                                                                |                     |
| /s/ RICHARD L. WENNEKAMP                                                                                                                                                                                                                                                                                                                                    | Director                                                            | July      16, 2010       |
| Richard      L. Wennekamp                                                                                                                                                                                                                                                                                                                                        |                                                                |                     |

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| ExhibitNumber |   | Description                                                                                                                                                 |   |
|---------------|--------|-------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|
| 31.1          |   | Certification      of Chief Executive Officer Pursuant to 15 U.S.C. Section 7241, as adopted      pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 |   |
| 31.2          |   | Certification      of Chief Financial Officer Pursuant to 15 U.S.C. Section 7241, as adopted      pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 |   |
| 32.1          |   | Certification      of Chief Executive Officer Pursuant to 18 U.S.C. Section 1350, as adopted      pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 |   |
| 32.2          |   | Certification      of Chief Financial Officer Pursuant to 18 U.S.C. Section 1350, as adopted      pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 |   |