Exhibit 10.45


 


	
  AMENDMENT
  OF SOLICITATION/MODIFICATION OF CONTRACT

  	
   

  	
  1. CONTRACT ID CODE

  	
   

  	
  PAGE OF PAGES

  
	
   

  	
   

  	
   

  	
   

  	
  1

  	
   

  	
  2

  



	
   

  	
   

  	
   

  	
   

  
	
  2.  AMENDMENT/MODIFICATION
  NO

  	
  3.  EFFECTIVE DATE

  	
  4.  REQUISITION/PURCHASE
  REQ. NO.

  	
  5.  PROJECT
  NO. (If applicable)

  
	
  01

  	
  See 16C

  	
  VR092

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
  ISSUED BY

  	
  CODE

  	
  2668-30052

  	
  7.  ADMINISTERED
  BY (If other than Item 6)

  	
  CODE

  	
   

  
	
   

  National Institutes of
  Health

  Contract Management
  Branch, NIAID

  6700-B Rockledge Drive

  Room 2230, MSC 7612

  Bethesda, MD 20892-7612

   

  	
  DMID-VR

  
	
   

  
	
  8.  NAME AND ADDRESS OF CONTRACTOR (No., street, country, State and ZIP Code)

  	
  x

  	
  9A.  AMENDMENT
  OF SOLICITATION NO.

  
	
   

  
	
  Avacia Limited

  PO Box 42, Hexagon House

  Blackley

  Manchester, M9 8ZS

  England

  	
   

  	
  9B.  DATED (SEE ITEM 11)

   

  
	
  x

  	
  10A.  MODIFICATION
  OF CONTRACT/ORDER NO.

  
	
  NO1-AI-30052

   

  
	
   

  	
  10B.  DATED (SEE ITEM 13)

  
	
  CODE

  	
  FACILITY CODE

  	
  September 30, 2003

  
	
   

  	
   

  	
   

  	
   

  
	
  11.  THIS ITEM ONLY APPLIES TO AMENDMENTS OF
  SOLICITATIONS

  
	
   

  
	
  o The above numbered solicitation is
  amended as set forth in Item 14.  The
  hour and date specified for receipt of Offers o is extended, o is not extended.

   

  Offers must acknowledge
  receipt of this amendment prior to the hour and date specified in the
  solicitation or as amended, by one of the following methods:  (a) By completing Items 8 and 15, and
  returning copies of the amendment; (b) By acknowledging receipt of this
  amendment on each copy of the offer submitted; or (c) By separate letter
  or telegram which includes a reference to the solicitation and amendment
  numbers.  FAILURE OF YOUR
  ACKNOWLEDGEMENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF
  OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF
  YOUR OFFER.  If by virtue of this
  amendment, you desire to change an offer already submitted, such change may
  be made by telegram or letter, provided each telegram or letter makes
  reference to the solicitation and this amendment, and is received prior to
  the opening hour and date specified.

   

  
	
  12.  ACCOUNTING AND APPROPRIATION DATA (If required)

  DOC#300N1AI30052A  EIN  1-900216013-A1     CAN  3-8460924                    SOCC#
  25.55                [***]

   

  
	
  13.  THIS ITEM APPLIES ONLY TO MODIFICATIONS OF
  CONTRACTS/ORDERS, IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

   

  
	
   

  	
  A.

  	
  THIS
  CHANGE ORDER IS ISSUED PURSUANT TO:  (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE
  MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.

   

  
	
   

  	
  B.

  	
  THE
  ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE
  CHANGES (such as changes in paying office, appropriation date,
  etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR
  43.103(b).

   

  
	
   

  	
  C.

  	
  THIS
  SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:

  
	
  x

  	
  D.

  	
  OTHER
  (Specify type of modification and authority)

  Unilateral
  - Article B.2.f.

   

  
	
  E.  IMPORTANT: 
  Contractor x is not, o is required to sign this document and return copies
  to the issuing office.

   

  
	
  14.  DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract
  subject matter where feasible)

  
	
  PURPOSE: 
  The purpose of this modification is to add an increment of funds.

   

  
										



	
   

  	
   

  	
  TOTAL FUNDS ALLOTTED

  	
   

  	
  TOTAL ESTIMATED COST

  	
   

  
	
  AMOUNT

  	
   

  	
  Cost

  	
   

  	
  Fixed Fee

  	
   

  	
  CPFF

  	
   

  	
  Cost

  	
   

  	
  Fixed Fee

  	
   

  	
  CPFF

  	
   

  
	
  Total Prior to
  this MOD:

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
  MOD #01:

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
  TOTAL

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  



	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  COMPLETION DATE:  [***]

  
	
  FUNDED THROUGH:   [***]

  
	
   

  
	
  Except as provided
  herein, all terms and conditions of the document referenced in Item 9A or
  10A, as heretofore changed, remains unchanged and in full force and effect.

   

  
	
  15A.  NAME AND TITLE OF SIGNER (Type or print)

  	
  16A.  NAME AND TILE OF CONTRACTING OFFICER (Type or print)

  
	
   

  	
  [***]

  
	
   

  	
  [***]

  
	
   

  	
   

  
	
  15B.  CONTRACTOR/OFFEROR

  	
  15C.  DATE SIGNED

  	
  16B.  UNITED STATES OF AMERICA

  	
  16C.  DATE SIGNED

  
	
   

  	
   

  	
   

  	
  [***]

  
	
   

  	
   

  	
  BY

  	
  [***]

  	
   

  
	
  (Signature of person authorized to sign)

  	
   

  	
   

  	
  (Signature
  of Contracting Officer)

  	
   

  
	
   

  	
   

  	
   

  
	
  NSN 7540-01-152-8070

  	
  OMB
  No. 0990-0115

  	
  STANDARD
  FORM 30
  (REV. 10-83)

  
											



 

















 


	
  Special Provisions

  	
  Contract No.
  N01-AI-30052

  	
  Page 2 of 2

  
	
   

  	
  Modification
  No. 01

  	
   

  



 


ARTICLE B.2. ESTIMATED COST AND FIXED FEE - paragraphs
d, e and g are modified to read as follows:


 


	
  d.

  	
  Total funds
  currently available for payment and allotted to this contract are increased
  by [***] from [***] to [***] of which [***] represents the estimated costs,
  and of which [***] represents the fixed fee. These funds cover the start
  dates for Milestones 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16,
  and 17. For further provisions on funding see the LIMITATION OF FUNDS clause
  referenced in Part II, Article 1.2. Authorized Substitutions of
  Clauses.

  
	
   

  	
   

  
	
  e.

  	
  It is
  estimated that the amount currently allotted will cover performance of the
  contract through [***].

  
	
   

  	
   

  
	
  g.

  	
  Future increments
  to be allotted to this contract are estimated as follows:

  



 


	
  FY

  	
   

  	
  PERIOD

  	
   

  	
  ESTIMATED COST

  	
   

  	
  FIXED FEE

  	
   

  
	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  



 


	
   

  	
  These funds
  cover continuation of Milestones 7, 9, 10, 11, 12, 13, and 17.

  
	
   

  	
   

  
	
   

  	
  No other
  terms and conditions are changed by this modification.

  



 

















 


[Letterhead of Department of Health and Human Services]


 


August 9, 2004


 


	
  Our
  Reference:

  	
  Contract
  No. N01-AI-30052

  
	
   

  	
  Modifications
  03

  



 


Avecia Limited

PO Box 42, Hexagon House

Blackley

Manchester, M9 8ZS

England


 


[***]


 


[***]


 


We are enclosing an executed
copy of the referenced modification for your retention.  Should you have any questions regarding its
administration, please do not hesitate to contact me on (301) 402-6298 or write
to:


 


Contracting Officer

National Institute of Allergy
   and Infectious Diseases

National Institutes of Health

6700-B Rockledge Drive

Room 3214, MSC 7612

Bethesda, Maryland 20892-7612


 


Sincerely,


 


 


[***]


 


[***]

Contracting Officer

Contract Management Branch

National Institute of Allergy
     and Infectious Diseases


 
















 


	
  AMENDMENT
  OF SOLICITATION/MODIFICATION OF CONTRACT

  	
   

  	
  1. CONTRACT ID CODE

  	
   

  	
  PAGE OF PAGES

  
	
   

  	
   

  	
   

  	
   

  	
  1

  	
   

  	
  3

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  2.
  AMENDMENT/MODIFICATION NO 

  	
  3.
  EFFECTIVE DATE

  	
   

  	
  4.
  REQUISITION/PURC 

  	
   

  	
  5.
  PROJECT NO. (if applicable) 

  
	
  03

  	
  See Block 16 C

  	
   

  	
  N/A

  	
   

  	
  N/A

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  6. ISSUED BY

  	
   

  	
  CODE

  	
   

  	
   

  	
   

  	
  7. ADMINISTERED BY (if other than Item 6)

  	
   

  	
  CODE

  	
           

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  National Institutes of
  Health

  Contract Management
  Branch, NIAID

  6700-B Rockledge Drive

  Room 2230, MSC 7612

  Bethesda, MD 20892-7612

  	
   

  	
   

  DMID - VRCB

  
	
   

  	
   

  	
   

  
	
  8. NAME AND ADDRESS OF
  CONTRACTOR (No., street, county, State, and ZIP Code)
  

  	
   

  	
  x

  	
   

  	
  9A. AMENDMENT OF
  SOLICITATION NO.

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Avecia, Limited

  	
   

  	
   

  	
   

  	
  9B. DATED (SEE ITEM 11)

  
	
  P.O. Box
  42 Hexagon House

  	
   

  	
   

  	
   

  	
   

  
	
  Blackleyh

  	
   

  	
  x

  	
   

  	
  10A. MODIFICATION OF
  CONTRACT/ ORDER NO.

  
	
  Manchester,
  M9 8ZS

  	
   

  	
   

  	
   

  	
  N01-AI-30052

  
	
  England

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
  10B.
  DATED (SEE ITEM 13) 

  
	
   

  	
   

  	
   

  	
   

  	
  September 29, 2003

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  CODE

  	
  FACILITY
  CODE

  	
   

  	
   

  	
   

  	
   

  
																						



 


11.  THIS ITEM ONLY APPLIES TO AMENDMENTS OF
SOLICITATIONS


 


o 
The above numbered solicitation is amended as set forth in Item 14.  The hour and date specified for receipt of
Offers o is extended, o is
not extended.


 


Offers must acknowledge
receipt of this amendment prior to the hour and date specified in the
solicitation or as amended, by one of the following methods:  (a) By completing Items 8 and 15, and
returning                 
copies of the amendment; (b) By acknowledging receipt of this amendment on
each copy of the offer submitted; or (c) By separate letter or telegram
which includes a reference to the solicitation and amendment numbers.  FAILURE OF YOUR ACKNOWLEDGEMENT TO BE
RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR
AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER.  If by virtue of this amendment, you desire to
change an offer already submitted, such change maybe made by telegram or
letter, provided each telegram or letter makes reference to the solicitation
and this amendment, and is received prior to the opening hour and date
specified.


 


12.  ACCOUNTING AND APPROPRIATION DATA (If required)


N/A


 


13.  THIS ITEM APPLIES ONLY TO MODIFICATIONS OF
CONTRACTS/ORDERS, IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.


 


	
  {PRIVATE}

  	
  A.    THIS CHANGE ORDER IS ISSUED PURSUANT
  TO:  (Specify
  authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE
  CONTRACT ORDER NO. IN ITEM 10A

  
	
   

  	
   

  
	
   

  	
  B.     THE ABOVE NUMBERED CONTRACT/ORDER IS
  MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as
  changes in paying office, appropriation date, etc.) SET FORTH IN
  ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b)

  
	
   

  	
   

  
	
  x

  	
  C.     THIS SUPPLEMENTAL AGREEMENT IS ENTERED
  INTO PURSUANT TO THE AUTHORITY OF:

  FAR 1.602-1

  
	
   

  	
   

  
	
   

  	
  D.    OTHER (Specify type of
  modifications and authority)

   

  
	
  E.  IMPORTANT: 
  Contractor o is not, o is required to sign this document and return 2 copies to the issuing office.

  
	
  14. 
  DESCRIPTION OF AMENDMENT MODIFICATION (Organized
  by UCF section headings, including solicitation/contract subject matter where
  feasible)

   

  PURPOSE:  To
  modify ARTICLE G.1- PROJECT OFFICER and ARTICLE B.4 - ADVANCE UNDERSTANDINGS.

   

  Total Estimated Cost Plus Fixed Fee - [***]
  (Unchanged)

  Total Funds Allotted:  [***]
  (Unchanged)

   

  Completion Date:  [***] (Unchanged)

  Funded Through:  [***] (Unchanged)

  
	
   

  
	
  Except as provided
  herein, all terms and conditions of the document referenced in Item 9A or
  10A, as heretofore changed, remains unchanged and in full force and effect.

  
	
   

  
	
  15A.  NAME AND TITLE OF SIGNER (Type or print)

   

  [***]

  	
  16A.  NAME AND TITLE OF CONTRACTING OFFICER (Type or print)

  [***]

  [***]

  
	
   

  	
   

  
	
  15B.  CONTRACTOR/OFFEROR

   

  [***]

  	
   

  	
  15C. DATE SIGNED

   

  3August2004

  	
  16B.  UNITED STATES OF AMERICA



  	
  16C.  DATE SIGNED

   

   8/6/04

  
	
  BY

  	
  [***]

  
	
  (Signature of person authorized
  to sign)

  	
   

  	
  (Signature
  of Contracting Officer)

  	
   

  
	
   

  
	
  NSN 7540-01-152-8070

  	
  OMB No. 9009-0115

  	
  STANDARD FORM 30 (REV. 10-83)

  FAR (48 CFR) 53.243

  
									



 

















 


	
  {PRIVATE} Special Provisions

  	
  Contract No.
  N01-AI-30052

  	
  Page 2 of 3

  
	
   

  	
  Modification
  No. 03

  	
   

  



 


The
following name and address associated with the NIAID contracts organization are
modified where they appear in the contract:


 


	
  DELETE

  	
  REPLACE
  WITH

  
	
   

  	
   

  
	
  Contract
  Management Branch

  	
  Contract
  Management Program

  
	
  CMB,
  NIAID, NIH

  	
  CMP,
  NIAID, NIH

  
	
  Room 2230,
  MSC 7612

  	
  Room 3214,
  MSC 7612

  
	
  6700-B
  Rockledge Drive

  	
  6700-B
  Rockledge Drive

  
	
  Bethesda,
  MD 20892-7612

  	
  Bethesda,
  MD 20892-7612

  



 


ARTICLE
B.4. ADVANCE UNDERSTANDINGS paragraph p. is added to
the contract
as follows:


 


p.               The Centers for
Disease Control and Prevention (CDC) will supply the following to Avecia under
this contract as Government furnished information:


 


Current technical protocols
for:


 


[***]


 


The Center for Disease Control
will also supply uncontrolled copies of all associated quality system documents
for the proper implementation of these protocols.


 


CDC will initiate a separate
agreement with Avecia to transfer the above information.  The agreement will allow Avecia to share this
information with contractors that will be bidding [***].


 


When Avecia selects their
subcontractor, CDC may, pending further discussion and agreement with NIH,
provide public domain and proprietary computer software algorithms for the
implementation of these protocols, a limited quantity of reagents, and
technical or intellectual oversight for a technology transfer activity to the
successful subcontractor.


 

















 


	
  {PRIVATE} Special Provisions

  	
  Contract No.
  N01-AI-30052

  	
  Page 3 of 3

  
	
   

  	
  Modification
  No. 03

  	
   

  



 


ARTICLE
G.1. PROJECT OFFICER is replaced in its entirety
with the following:


 


The following Project Officers will represent
the Government for the purpose of this contract:


 


[***]

[***]

[***]

[***]

DHHS/NIH/NIAID

6610 Rockledge Dr, Room 5119, MSC 6604

Bethesda, MD 20892-6604

ph 301-451-4806

fax 301-480-1263

swinram@niaid.nih.gov


 


[***]


 


[***]

[***]

[***]

DHHS/NIH/NIAID

6610 Rockledge Dr, Room 5002, MSC 6604

Bethesda, MD 20892-6604

ph 301-451-6737

fax 301-480-1263

eflynn@niaid.nih.gov


 


The Project Officer is
responsible for:  (1) monitoring the
Contractor’s technical progress, including the surveillance and assessment of
performance and recommending to the Contracting Officer changes in
requirements; (2) interpreting the Statement of Work and any other
technical performance requirements; (3) performing technical evaluation as
required; (4) performing technical inspections and acceptances required by
this contract; and (5) assisting in the resolution of technical problems
encountered during performance.


 


The Contracting Officer is the
only person with authority to act as agent of the Government under this contract.  Only the Contracting Officer has authority
to:  (1) direct or negotiate any
changes in the Statement of Work; (2) modify or extend the period of
performance; (3) change the delivery schedule; (4) authorize
reimbursement to the Contractor any costs incurred during the performance of
this contract; or (5) otherwise change any terms and conditions of this
contract.


 


The Contracting Officer hereby
delegates the Project Officer as the Contracting Officer’s authorized
representative responsible for signing software license agreements issued as a
result of this contract.


 


The Government may unilaterally
change its Project Officer designation.


 
















 


	
  AMENDMENT
  OF SOLICITATION/MODIFICATION OF CONTRACT

  	
   

  	
  1.

  	
  CONTRACT ID CODE

  	
   

  	
  PAGE OF PAGES

  
	
   

  	
   

  	
   

  	
  N/A

  	
   

  	
  1

  	
   

  	
  3

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  



	
  2.  AMENDMENT/MODIFICATION NO.

  04

  	
  3.  EFFECTIVE DATE

  see block 16C, below

  	
  4.  REQUISITION/PURCHASE REQ. NO.

  VRCB146

  	
  5.  PROJECT NO. (if
  applicable)

  
	
   

  	
   

  	
   

  	
   

  
	
  6.  ISSUED BY

  	
  CODE

  	
   

  	
  ADMINISTERED BY (if other than Item 6)

  VR

  	
  CODE

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
  National Institutes of
  Health

  National Institute of
  Allergy and Infectious Diseases

  DEA, Contract Management
  Program

  Room 3214, MSC 7612

  6700-B Rockledge Drive

  Bethesda, MD 20892-7912

   

  	
   

  
	
  8.  NAME AND ADDRESS OF CONTRACTOR (No. Street, County, State and ZIP Code)

  	
  o

  	
  9A.  AMENDMENT OF SOLICITATION NO.

   

  
	
  Avecia Ltd

  P.O. Box 42,
  Hexagon House

  	
   

  	
  9B.  DATED (SEE ITEM 11)

   

  
	
  Blackley

  Manchester, M9 8ZS

  	
   

  	
  10A.  MODIFICATION OF CONTRACT/ORDER NO.

  N01-AI-30052

   

  
	
  England

  	
  x

  	
  10B.  DATED (SEE ITEM 13)

  
	
  CODE 

  	
  FACILITY CODE

  	
   

  	
  September 29, 2003

  
											



 


11.  THIS ITEM ONLY APPLIES TO AMENDMENTS OF
SOLICITATIONS


 


o The above numbered solicitation is amended and set
forth in Item 14. The hour and date specified for receipt of Offers o is extended, o is
not extended.


 


Offers must acknowledge
receipt of this amendment prior to the hour and the specified in the
solicitation or as amended, by one of the following methods: 


 


(a) By completing
Items 8 and 15, and returning (1) copy of the amendment, (b) By
acknowledging receipt of this amendment on each copy of the offer submitted; or
(c) By separate letter or telegram which includes a reference to the solicitation
and amendment numbers.  FAILURE OF YOUR
ACKNOWLEDGMENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS
PRIOR TO THE HOUR AND DATA SPECIFIED MAY RESULT IN REJECTION OF YOUR
OFFER.  If by virtue of this amendment
you desire to change an offer already submitted, such change may be made by
telegram or letter, provided each telegram or letter makes reference to the
solicitation and this amendment, and is received prior to the opening hour and
date specified.


 


12.  ACCOUNTING AND APPROPRIATION DATA (If required


EIN #1-900216013-A1            CAN #4-8460924 - [***]       SOC #25.55           [***]


 


13.  THIS ITEM APPLIES ONLY TO MODIFICATIONS OF
CONTRACTS/ORDERS,

IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.


 


	
  o

  	
  A.    THIS CHANGE ORDER IS ISSUED PURSUANT
  TO:  (Specify
  authority)  THE CHANGES
  SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.

   

  
	
   

  	
  B.     THE ABOVE NUMBERED CONTRACT/ORDER IS
  MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as
  changes in paying office, appropriation date, etc.) SET FORTH IN
  ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).

   

  
	
   

  	
  C.     THIS SUPPLEMENTAL AGREEMENT IS ENTERED
  INTO PURSUANT TO AUTHORITY OF:

   

  
	
  

  x

  	
  D.    OTHER (Specify type of
  modification and authority)

  Article B.2.f.

   

  
	
  E.  IMPORTANT: 
  Contractor  x is not, o is required to sign this document and return copies
  to the issuing office.

  
	
   

  
	
  14.  DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract
  subject matter where feasible.)

   

  PURPOSE: 
  To provide incremental funding and to update Section H. articles.

  



 


	
   

  	
  TOTAL FUNDS ALLOTTED

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  Estimated Cost

  	
   

  	
  Fixed Fee

  	
   

  	
  Total Allotted Amount

  	
   

  	
   

  
	
  Prior to this mod:

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
   

  
	
  This modification #4:

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
   

  
	
  Total:

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
   

  
	
  Total Funds Allotted:  [***]

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  TOTAL Contract
  Amount:  [***]

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Funded Through:  [***]

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Contract Completion
  Date:  [***]

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  



 


	
  Except as provided
  herein, all terms and conditions of the document referenced in Item 9A or
  10A, as heretofore changed, remains unchanged and in full force and effect.

  
	
   

  
	
  15A.  NAME AND TITLE OF SIGNER (Type or print)

  	
  16A.  NAME AND TITLE OF CONTRACTING OFFICER (Type or print)

  [***]

   

  
	
  15B.  CONTRACTOR/OFFEROR



  	
   

  	
  15C. DATE SIGNED

  	
  16B.  UNITED STATES OF AMERICA

  [***]

   

  	
  16C.  DATE SIGNED

  [***]

  
	
  BY

  	
   

  
	
  (Signature of person authorized
  to sign)

  	
   

  	
  (Signature
  of Contracting Officer)

  	
   

  
	
   

  	
   

  	
   

  
	
  NSN 7540-01-152-8070

  PREVIOUS EDITION
  UNUSABLE

  	
  30-105

  Computer Generated

  	
  STANDARD FORM 30
  (REV. 10-83)

  Prescribed by GSA

  FAR (40 CFR) 53.243

  
								



 

















 


	
  SPECIAL PROVISIONS

  	
  CONTRACT
  No. N01-AI-30052

  	
  Page 2 of 3 Pages

  
	
   

  	
  Modification
  No. 4

  	
   

  



 


ARTICLE B.2. ESTIMATED COST AND FIXED FEE
- paragraphs d., e. and g. are hereby modified to read as follows:


 


d.              Total funds currently
available for payment and allotted to this contract are hereby increased by
[***] from [***] to [***]; of which [***] represents an increase to the
estimated cost from [***] to [***] and of which [***] represents an increase to
the fixed fee from [***] to [***].  For
further provisions on funding, see the LIMITATION OF FUNDS Clause referenced in
Part II, ARTICLE 1.2., Authorized Substitution of Clauses.


 


e.               It is estimated
that the amount currently allotted will cover performance of the contract
through [***].


 


g.              Future increments to
be allotted to this contract are estimated as follows:


 


	
  PERIOD

  	
   

  	
  ESTIMATED
  COST

  	
   

  	
  FIXED
  FEE

  	
   

  	
  TOTAL
  AMOUNT

  
	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  



 


ARTICLE
H.6. CONTINUED BAN ON FUNDING OF HUMAN EMBRYO RESEARCH
- paragraph b. is hereby modified to add the following:


 


	
  b.

  	
   

  	
  Public Law and Section No.

  	
   

  	
  Fiscal
  Year

  	
   

  	
  Period
  Covered

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  P.L.
  108-199, Title V-General Provisions, Section 510

  	
   

  	
  2004

  	
   

  	
  10/01/2003
  -09/30/2004

  



 


ARTICLE H.7. 
NEEDLE EXCHANGE -  paragraph b. is hereby modified to add the
following:


 


	
  b.

  	
   

  	
  Public Law and Section No.

  	
   

  	
  Fiscal Year

  	
   

  	
  Period Covered

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  P.L.
  108-199, Title V-General Provisions, Section 505

  	
   

  	
  2004

  	
   

  	
  10/01/2003  09/30/2004

  



 


ARTICLE
H.12.  SALARY RATE LIMITATION
LEGISLATION PROVISIONS, paragraphs b and c are
hereby modified to add the following:


 


	
  b.

  	
   

  	
  Public Law. No.

  	
   

  	
  Fiscal Year

  	
   

  	
  Dollar Amount of Salary
  Limitation

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  P.L.
  108-199, Title II - General Provisions, Section 204

  	
   

  	
  2004

  	
   

  	
  Executive
  Level I

  



 


c.               Direct salaries
which will be paid with FY-04 funds are limited to the Executive Level 1 rate
which was in effect on the date(s) the expense was incurred.


 






*For contract expenditures using FY-04 funds, the Executive Level I rate
for the period 10/1/03 - 12/31/03 is $171,900. 
Effective 1/1/04, for contract expenditures using FY-04 funds, the
Executive Level 1 rate was increased to $175,700 and will remain at that level
until such time as it is determined to raise the Executive Schedule annual
rates.  See the web site listed below for
Executive Schedule rates of pay.


 


LINK to EXECUTIVE LEVEL SALARIES: 
http://www.opm.gov/oca/PAYRATES/index.htm

(Click on “Executive Schedule” for the current Fiscal Year’s salary rate or
scroll down to the “General Schedule Salary Tables from Previous Years” to
locate the Executive Level salary rates from previous years.)


 


	
  NOTE:

  	
  All
  prior Public Laws and related Executive Levels incorporated in the Basic
  Award and all previous Modifications shall remain in effect for the
  applicable fiscal year and related funds.

  



 

















 


	
  SPECIAL
  PROVISIONS

  	
  CONTRACT
  No. N01-AI-30052

  	
  Page 3 of 3 Pages

  
	
   

  	
  Modification
  No. 4

  	
   

  



 


ARTICLE H.14. 
PRESS RELEASES, paragraph b., is hereby
modified to add the following:


 


	
  b.

  	
   

  	
  Public Law and Section No.

  	
   

  	
  Fiscal Year

  	
   

  	
  Period Covered

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  P.L.
  108-199, Title V - General Provisions, Section 507

  	
   

  	
  2004

  	
   

  	
  10/01/2003-09/30/2004

  



 


ARTICLE
H.16.  ANTI-LOBBYING,
paragraph c. is hereby modified to add the following:


 


	
  a.

  	
   

  	
  Pursuant to
  Public Law(s) cited in paragraph c., below, contract funds shall not be
  used, other than for normal and recognized executive-legislative
  relationships, for publicity or propaganda purposes, for the preparation,
  distribution, or use of any kit, pamphlet, booklet, publication, radio,
  television, or video presentation designed to support or defeat legislation
  pending before the Congress or any State legislature, except in presentation
  to the Congress or any State legislature itself.

  
	
   

  	
   

  	
   

  
	
  b.

  	
   

  	
  Contract
  funds shall not be used to pay salary or expenses of the contractor or any
  agent acting for the contractor, related to any activity designed to
  influence legislation or appropriations pending before the Congress or any
  State legislature.

  



 


	
  c.

  	
   

  	
  Public Law and Section No.

  	
   

  	
  Fiscal Year

  	
   

  	
  Period Covered

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  for a.
  above:

  P.L. 108-199, Title V - General Provisions, Section 503a

  	
   

  	
  2004

  	
   

  	
  10/01/2003 -
  09/30/2004

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  for b.
  above:

  P.L. 108-199, Title V - General Provisions, Section 503b

  	
   

  	
  2004

  	
   

  	
  10/01/2003 -
  09/30/2004

  



 


	
   

  	
   

  	
  All
  other terms and conditions of the contract remain unchanged.

  



 
















 


	
  AMENDMENT OF
  SOLICITATION/MODIFICATION OF CONTRACT

  	
  1.  CONTRACT ID CODE

  	
  PAGE OF PAGES

  
	
   

  	
   

  	
  1

  	
  8

  
	
   

  	
   

  	
   

  	
   

  
	
  2.  AMENDMENT /MODIFICATION NO

  Mod #06

  	
  3.  EFFECTIVE DATE

  See Block 16 C

  	
  4.  REQUISITION/PURC

  N/A

  	
  5.  PROJECT NO. (If applicable)

  N/A

  
	
   

  	
   

  	
   

  	
   

  
	
  6.  ISSUED BY

  	
  CODE

  	
   

  	
  7.  ADMINISTERED BY (If other than Item 6)

  	
  CODE

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  National Institutes of
  Health

  	
   

  
	
  Contract Management
  Program, NIAID

  	
   

  
	
  6700-B Rockledge Drive 

  	
   

  
	
  Room 3214, MSC 7612

  	
   

  
	
  Bethesda, MD 20892-7612

  	
   

  
	
   

  	
   

  
	
  8.  NAME AND ADDRESS OF CONTRACTOR (No., street,
  county, State and Zip Code)

  	
  x

  	
  9A.  AMENDMENT OF SOLICITATION NO.

  
	
   

  	
   

  	
   

  
	
   

  	
  Avecia Limited

  	
   

  	
  9.B.  DATED (SEE ITEM 11)

  
	
   

  	
  P.O. Box 42,
  Hexagon House

  	
   

  	
   

  
	
   

  	
  Blackley, Manchester, M9
  8ZS, UK

  	
   

  	
   

  
	
   

  	
  x

  	
  10A.  MODIFICATION PF CONTRACT/ORDER NO.

  
	
   

  	
   

  	
  N01-AI-30052

   

  
	
   

  	
   

  	
  10B.  DATED (SEE ITEM 13)

  
	
  CODE

  	
  FACILITY CODE

  	
   

  	
  September 29, 2003

  
														



 


11.  THIS ITEM ONLY APPLIES TO AMENDMENTS OF
SOLICITATIONS


 


“ The above numbered
solicitation is amended as set forth in item 14.  The hour and date specified for receipt of
offers” is extended. “  is not extended.


 


Offers must acknowledge
receipt of this amendment prior to the hour and date specified in the
solicitation or as amended, by one of the following methods:  (a) By completing items 8 and 15, and
returning                  
copies of the amendment:  (b) By
acknowledging receipt of this amendment on each copy of the offer submitted; or
(c) By separate letter or telegram which includes a reference to the
solicitation and amendment numbers. 
FAILURE OF YOUR ACKNOWLEDGEMENT TO BE RECEIVED AT THE PLACE DESIGNATED
FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN
REJECTION OF YOUR OFFER.  If by virtue of
this amendment, you desire to change an offer already submitted, such change
may be made by telegram or letter, provided each telegram or letter makes
reference to the solicitation and this amendment, and is received prior to the
opening hour and date specified.


 


12.  ACCOUNTING AND APPROPRIATION DATA (If
required)


 


13.  THIS ITEM APPLIES ONLY TO MODIFICATIONS OF
CONTRACTS/ORDERS.  IT MODIFIES THE
CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.


 


	
  x  

  	
  A.

  	
  THIS CHANGE ORDER IS
  ISSUED PURSUANT TO:  (Specify
  authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER
  NO. IN ITEM 10A.

  
	
  x

  	
  FAR 43.202

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  B.

  	
  THE ABOVE NUMBERED
  CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office, appropriation date, etc.)
  SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(B).

  
	
   

  	
   

  	
   

  
	
   

  	
  C.

  	
  THIS SUPPLEMENTAL
  AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF: FAR 1.602-1 AND 52.243-2,
  Changes - Cost Reimbursement, Alternate V

  
	
   

  	
   

  	
   

  
	
   

  	
  D.

  	
  OTHER (Specify type of modification and authority)

  
	
   

  	
   

  
	
  E.  IMPORTANT: 
  Contractor o is not, x is required to sign this document and return 3 copies
  to the issuing office

  
	
   

  
	
  14.  DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract
  subject matter where feasible)

  
	
   

  
	
  PURPOSE:  To issue a Change Order to the Statement of
  Work and revise the milestone payment schedule in Article B.4.

  
	
   

  
	
  TOTAL AMOUNT
  FUNDED:  [***]

  
	
  TOTAL ESTIMATED
  COST:  [***]

  
	
  FUNDED THROUGH:  [***]

  
	
  CONTRACT EXPIRATION
  DATE:  [***]

  
	
   

  
	
  Except as provided
  herein, all terms and conditions of the document referenced in Item 9A or
  10A, as heretofore changes, remains unchanges and in  full force and effect

  
	
   

  
	
  15A.  NAME AND TITLE OF SIGNER (Type or Print)

  	
  16A.  NAME AND TITLE OF CONTRACTING OFFICER (Type or print)

  
	
   [***]

  	
   

  
	
   

  	
   

  
	
  15B. CONTRACTOR/OFFEROR

  	
  15C.  DATE SIGNED

  	
  16B.  UNITED STATES OF AMERICA

  	
  16C.  DATE SIGNED

  
	
   [***]

  	
        27JUL05

  	
   [***]

   [***]

   

  	
  [***]

  
	
  [***]

  	
   

  	
  BY

  	
  [***]

  	
   

  
	
  (Signature
  of person authorized to sign)

  	
   

  	
  (Signature
  of contracting Officer)

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
  NSN 7540-01-152-8070

  	
  OMB No. 0990-0115

  	
  STANDARD FORM 30 (REV. 10-83)

  Far (48 CFR) 53.243

  
										



 

















 


	
  SPECIAL
  PROVISIONS

  	
  CONTRACT
  No. HHSN26620030052C

  	
  Page 2 of pages 8

  
	
   

  	
  Modifications
  No. 6

  	
   

  



 


ARTICLE B.4.  ADVANCE UNDERSTANDINGS
- Paragraph h., item 17 is deleted, and items 4-8, and 10-16 are hereby revised
as follows:


 


h.  Contract Milestones


 


The Contractor shall complete all work in accordance with the Statement
of Work and the contract milestones set forth below.  The distribution of the fixed fee shall be
paid in milestone based installments and payment of this fee shall be
determined by the Project Officer’s written certification that the milestone
has been satisfactorily performed and that the technical requirements have been
met regarding the completion of the following milestones:  If the Contractor meets the milestones
earlier than the dates set forth below, then the fee will be paid at the
earlier date after completion of the milestone.


 


	
   

  	
   

  	
  MILESTONES FOR AVECIA

  	
   

  	
  ESTIMATED COST

  	
   

  	
  FIXED FEE

  	
   

  	
  TOTAL CPFF

  
	
  4

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  5

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in two installments for this milestone based on the
  completion of the following items:

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  6

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in three installments for this milestone based on
  the completion of the following items:

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  



 

















 


	
  SPECIAL
  PROVISIONS

  	
  CONTRACT
  No. HHSN26620030052C

  	
  Page 3 of pages 8

  
	
   

  	
  Modification
  No. 6

  	
   

  



 


	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  7

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  8

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in six installments for this milestone based on the
  completion of the following items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  
	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  
	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  
	
   

  	
   

  	
  f) [***]

  	
   

  	
   

  	
   

  	
  f) [***]

  	
   

  	
   

  



 

















 


	
  SPECIAL
  PROVISIONS

  	
  CONTRACT
  No. HHSN26620030052C

  	
  Page 4 of pages 8

  
	
   

  	
  Modification
  No. 6

  	
   

  



 


	
  10

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in three installments for this milestone based on
  the completion of the following items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  11

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
  Fee shall be paid in three installments for this milestone based on
  the completion of the following items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  



 

















 


	
  SPECIAL
  PROVISIONS

  	
  CONTRACT
  No. HHSN26620030052C

  	
  Page 5 of pages 8

  
	
   

  	
  Modification
  No. 6

  	
   

  



 


	
  12

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in two installments for this milestone based on the
  completion of the following items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  13

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in six installments for this milestone based on the
  completion of the following items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  
	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  
	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  
	
   

  	
   

  	
  f) [***]

  	
   

  	
   

  	
   

  	
  f) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  14

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in three yearly installments for this milestone
  based on the completion of the following

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  



 

















 


	
  SPECIAL
  PROVISIONS

  	
  CONTRACT
  No. HHSN26620030052C

  	
  Page 6 of pages 8

  
	
   

  	
  Modification
  No. 6

  	
   

  



 


	
   

  	
   

  	
  items:

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  15

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in three equal installments (one each

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
  year) on provision of [***]

  	
   

  	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  16

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in three installments (one each

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
  year) upon completion of [***]

  	
   

  	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  



 

















 


	
  SPECIAL
  PROVISIONS

  	
  CONTRACT
  No. HHSN26620030052C

  	
  Page 7 of pages 8

  
	
   

  	
  Modification
  No. 6

  	
   

  



 


ARTICLE
B.4.  ADVANCE UNDERSTANDINGS
- Paragraph p., is added to read as follows:


 


p.  Contractor’s Statement of
Release


 


In consideration of the modification agreed to herein as complete
equitable adjustments for the Contractor’s doses reduction proposal for
adjustment, the Contractor hereby releases the Government from any and all
liability under this contract for further equitable adjustments attributable to
such facts or circumstances giving rise to the proposal for adjustment.


 


ARTICLE
G.1.  PROJECT OFFICER
- the second paragraph is hereby modified to replace the Co-Project Officer as
follows:


 


[***]

[***]

[***]

[***]

DHHS/NIH/NIAID/OBRA

Bethesda MD 20892

Ph:  (301) 451-6737

Fax:  (301) 480-1263/ (301) 480-3235

shrivass@niaid.nih.gov


 


SECTION J
- List of Attachments


 


ATTACHMENT
1, Statement of Work, Milestones 4-6, 8, 10-14, and 17
are hereby modified as follows:


 


[***]


 


[***]


 


[***]


 


[***]


 


[***]


 

















 


	
  SPECIAL
  PROVISIONS

  	
  CONTRACT
  No. HHSN26620030052C

  	
  Page 8 of pages 8

  
	
   

  	
  Modification
  No. 6

  	
   

  



 


[***]


 


[***]


 


[***]


 


[***]


 


Milestone
17:  DELETED.*


 


[***]


 


All other terms and conditions of the
contract remain unchanged.


 

















 


[Letterhead of Department of Health and Human Services]


 


September 13, 2005


 


[***]

Avecia Limited

P.O. Box 42, Hexagon House

Blackley, Manchester, M9 8ZS, UK


 


	
  Subject:

  	
   

  	
  Contract No. N01-AI-30052

  
	
   

  	
   

  	
  Modification
  No. 07

  



 


[***]


 


We are enclosing an executed
copy of the subject modification for your retention. If you have any questions
regarding its administration, please contact the Undersigned, at (301)
451-2617.


 


Sincerely,


 


[***]

[***]

Contract Specialist


 
















 


	
  AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

  	
  1.  CONTRACT ID CODE

  N/A

  	
  PAGE OF PAGES

  
	
  1

  	
  3

  
	
   

  	
   

  	
   

  	
   

  
	
  2.  AMENDMENT/MODIFICATION NO.

  07

  	
  3.  EFFECTIVE DATE

  [See block 16C, below]

  	
  4.  REQUISITION/PURCHASE REQ. NO.

  DMID 2 017

  	
  5.  PROJECT NO. (If
  applicable)

  N/A

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  ISSUED BY

  	
  CODE

  	
   

  	
  7.  ADMINISTERED BY (If other
  than Item 6)

  	
  CODE

  	
  N/A

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  National Institutes of
  Health

  National Institute of
  Allergy and Infectious Diseases

  DEA, Contract Management
  Branch

  Room 3214, MSC 7612

  6700-B Rockledge Drive

  Bethesda, MD 20892-7612

  	
  MID2-RCB

  
	
   

  
	
   

  	
   

  	
   

  
	
  8. NAME AND ADDRESS OF
  CONTRACTOR (No., street, country, State and ZIP Code)

  	
  x

  	
  9A. AMENDMENT OF
  SOLICITATION NO.

  
	
   

  
	
  Avacia Limited

  P.O. Box 42,
  Hexagon House

  Blackley, Manchester, M9
  8ZS, UK

  	
   

  	
  9B. DATED (SEE ITEM 11)

  
											



 


	
   

  	
   

  	
  x

  	
  10A.
  MODIFICATION OF CONTRACT/ORDER NO.

  
	
   

  	
   

  	
   

  	
  NO1-AI-30052

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
  10B.
  DATED (SEE ITEM 13)

  
	
  CODE

  	
  FACILITY CODE

  	
   

  	
  09/30/2003

  



 


11. THIS ITEM ONLY APPLIES TO
AMENDMENTS OF SOLICITATIONS


 


o 
The above numbered solicitation is amended as set forth in Item 14.  The hour and date specified for receipt of
Offers o is extended, o is
not extended.


 


Offers must acknowledge
receipt of this amendment prior to the hour and date specified in the
solicitation or as amended, by one of the following methods:  (a) By completing Items 8 and 15, and
returning
              
copies of the amendment; (b) By acknowledging receipt of this amendment on
each copy of the offer submitted; or (c) By separate letter or telegram
which includes a reference to the solicitation and amendment numbers.  FAILURE OF YOUR ACKNOWLEDGEMENT TO BE
RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR
AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER.  If by virtue of this amendment, you desire to
change an offer already submitted, such change may be made by telegram or
letter, provided each telegram or letter makes references to the solicitation
and this amendment, and is received prior to the opening hour and date
specified.


 


12. ACCOUNTING AND
APPROPRIATION DATA (If required)


DOC#300N1AI30052A           EIN 
1-900216013-A1            CAN  3-8460924     SOCC#
25.55           [***]


 


13. THIS ITEM APPLIES ONLY TO
MODIFICATIONS OF CONTRACTS/ORDERS, IT MODIFIES THE CONTRACT/ORDER NO. AS
DESCRIBED IN ITEM 14.


 


	
   

  	
  A.

  	
  THIS
  CHANGE ORDER IS ISSUED PURSUANT TO:  (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE
  MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.

  
	
   

  	
   

  	
   

  
	
   

  	
  B.

  	
  THE
  ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE
  CHANGES (such as changes in paying office, appropriation
  date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR
  43.103(b).

  
	
   

  	
   

  	
   

  
	
   

  	
  C.

  	
  THIS SUPPLEMENTAL
  AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:

  
	
   

  	
   

  	
   

  
	
  x

  	
  D.

  	
  OTHER (Specify type of modification and authority)

  P.L. 1.602-1; Limitation
  of Funds Clause and P.L. 108-447

   

  
	
  E.             IMPORTANT:  Contractor x is not, o is required to sign this document and
  return              
  copies to the issuing office.

   

  
	
  14.  DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract
  subject matter where feasible)

  
	
  PURPOSE: 
  Incremental Funding.

  



 


	
   

  	
   

  	
  Total
  Funds Currently Allotted

  	
   

  	
  Total
  Estimated Cost

  	
   

  
	
   

  	
   

  	
  Cost

  	
   

  	
  Fixed
  Fee

  	
   

  	
  CPFF

  	
   

  	
  Cost

  	
   

  	
  Fixed
  Fee

  	
   

  	
  CPFF

  	
   

  
	
  Total Prior to
  this Mod:

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
  Mod #01:

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
  Revised TOTAL

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  COMPLETION DATE:
  [***]

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  FUNDED THROUGH:
  [***]

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  



 


	
  Except as provided
  herein, all terms and conditions of the document referenced in Item 9A or
  10A, as heretofore changed, remains unchanged and in full force and effect.

  
	
   

  
	
  15A.  NAME AND TITLE OF SIGNER (Type or print)

  	
  16A.  NAME AND TILE OF CONTRACTING OFFICER (Type or print)

    [***]

    [***]

  
	
   

  	
   

  	
   

  	
   

  
	
  15B.  CONTRACTOR/OFFEROR

  	
  15C.  DATE SIGNED

  	
  16B.  UNITED STATES OF AMERICA

  	
  16C.  DATE SIGNED

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
                  [***]

  
	
   

  	
   

  	
   

  	
  BY

  	
  [***]

  	
   

  	
   

  
	
  (Signature
  of person authorized to sign)

  	
   

  	
  (Signature of Contracting
  Officer)

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
  NSN 7540-01-152-8070

  PREVIOUS EDITION
  UNUSABLE

  	
  30-105

  Computer Generated

  	
  STANDARD FORM 30 (REV.
  10-83)STANDARD
  FORM 30 (REV. 10-83  Prescribed by
  GSA

  FAR (48 CFR) 53.243

  
										



 

















 


	
  CONTRACT No. N01-AI-30052

  	
  SPECIAL
  PROVISIONS

  	
  Page 2 of 3

  
	
  Modification No. 07

  



 


ARTICLE B.2. 
ESTIMATED COST AND FIXED FEE, paragraphs d. and e., are hereby modified to read as
follows and paragraph g. is deleted in its entirety:


 


d.                                      Total funds currently available for
payment and allotted to this contract are hereby increased by [***] from [***]
to [***];  of which [***] represents an
increase to the estimated cost from [***] to [***];  and  of
which [***] represents an increase to the fixed fee from  [***] to 
[***].  For further provisions on
funding, see the LIMITATION OF COST Clause referenced in Part II, ARTICLE
1.1., General Clauses for a Cost-Reimbursement Research and Development
Contract.


 


e.                                       It is estimated that the amount currently
allotted will cover performance of the contract through [***]. By virtue of
this action, this contract is hereby fully funded.


 


ARTICLE H.6. 
CONTINUED BAN ON FUNDING OF HUMAN EMBRYO RESEARCH, paragraph b. is hereby modified to add
the following:


 


	
  b.

  	
  Public
  Law and Section No.

  	
   

  	
  Fiscal
  Year

  	
   

  	
  Period
  Covered

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  P.L. 108-447,
  Title V General Provisions, Section 509

  	
   

  	
  2005

  	
   

  	
  10/01/04-09/30/05

  	
   

  



 


ARTICLE H.7. 
NEEDLE EXCHANGE, paragraph b, is hereby modified to add the
following:


 


	
  b.

  	
  Public
  Law and Section No.

  	
   

  	
  Fiscal
  Year

  	
   

  	
  Period
  Covered

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  P.L. 108-447,
  Title V - General Provisions, Section 505

  	
   

  	
  2005

  	
   

  	
  10/01/04-09/30/05

  	
   

  



 


ARTICLE H.12. 
SALARY RATE LIMITATION LEGISLATION PROVISIONS, paragraphs b. and c. are hereby
modified to add the following:


 


	
  b.

  	
  Public
  Law No.

  	
   

  	
  Fiscal
  Year

  	
   

  	
  Dollar
  Amount of

  Salary Limitation*

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  P.L.
  108-447.  Title II, General Provisions,
  Section 204

  	
   

  	
  2005

  	
   

  	
  Executive Level I

  	
   

  



 


c.                                       Direct salaries are limited to the
Executive Level I rate which was in effect on the date(s) the expense was
incurred.


 






*For the period 10/1/04-12/31/04,
the Executive Level I rate is $175,700. Effective 1/1/05, the Executive Level I
rate increased to $180,100 and will remain at that rate until it is revised.
See the web site listed below for Executive Schedule rates of pay.


 


LINK
to EXECUTIVE LEVEL SALARIES:  http://www.opm.gove/oca/05tables/html/ex.asp (For previous years, go to:  http://www.opm.gove/oca/05tables/index.asp
and click on the year to locate the Executive Level salary rates.)


 


	
  NOTE:

  	
  All prior Public Laws and related Executive Levels
  incorporated in the Basic Award and all previous Modifications shall remain
  in effect for the applicable fiscal year and related funds.

  



 


HHS-556


 

















 


	
  CONTRACT No. N01-AI-30052

  	
  SPECIAL
  PROVISIONS

  	
  Page 3 of 3

  
	
  Modification No. 07

  



 


ARTICLE H.14. 
PRESS RELEASES, paragraph b., is hereby modified to add the
following:


 


	
  b.

  	
  Public
  Law and Section No.

  	
   

  	
  Fiscal
  Year

  	
   

  	
  Period
  Covered

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  P.L. 108-447,
  Title V - General Provisions, Section 506

  	
   

  	
  2005

  	
   

  	
  10/01/04-09/30/05

  	
   

  



 


ARTICLE H.16. 
ANTI-LOBBYING, paragraph c., is hereby modified to add the
following:


 


	
  c.

  	
  Public
  Law and Section No.

  	
   

  	
  Fiscal
  Year

  	
   

  	
  Period
  Covered

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  for b., above:  P.L. 108-447, Title V - General Provisions,
  Section 503b

  	
   

  	
  2005

  	
   

  	
  10/1/04-9/30/05

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  for
  a., above:  P.L. 108-447, Title V -
  General Provisions, Section 503a

  	
   

  	
  2005

  	
   

  	
  10/1/04-9/30/05

  	
   

  



 


ARTICLE I.2. 
AUTHORIZED SUBSTITUTION OF CLAUSES, is hereby modified to delete FAR Clause 52.232-22,
LIMITATION OF FUNDS (APRIL 1984), reinstating the applicability of FAR Clause
52.232-20, LIMITATION OF COST (APRIL 1984) of ARTICLE 1.1.


 


HHS-556


 
















 


	
  AMENDMENT OF
  SOLICITATION/MODIFICATION OF CONTRACT

  	
  1.  CONTRACT ID CODE

  N/A

  	
  PAGE OF PAGES

  
	
  1

  	
  4

   

  
	
  2.  AMENDMENT/MODIFICATION NO

  	
  3.

  	
  EFFECTIVE DATE

  	
  4.  REQUISITION/PURCHASE REQ. NO.

  	
  5.  PROJECT NO. (If applicable)

  
	
  08

  	
   

  	
  [See
  block 16C, below]

  	
   

  	
  N/A

  
	
   

  	
   

  	
   

  	
   

  
	
  ISSUED BY

  	
  CODE

  	
   

  	
  7.  ADMINISTERED BY (If other
  than Item 6)

  	
  CODE

  	
  N/A

  
	
   

  National Institutes of
  Health

  National Institute of
  Allergy and Infectious Diseases

  DEA, Contract Management
  Branch

  Room 3214, MSC 7612

  6700-B Rockledge Drive

  Bethesda, MD 20892-7612

   

  	
  MID-RCB-B

  
	
   

  
	
  8. NAME AND ADDRESS OF
  CONTRACTOR (No., street, county, State and ZIP Code)

  	
  x

  	
  9A. AMENDMENT OF
  SOLICITATION NO.

  
	
   

  
	
  Avacia Limited

  PO Box 42, Hexagon House

  Blackley, Manchester, M9
  8ZS, UK

  	
   

  	
  9B. DATED (SEE ITEM 11)

  
	
   

  	
  x

  	
  10A.
  MODIFICATION OF CONTRACT/ORDER NO.

  
	
   

  	
  N01-AI-30052

   

  
	
   

  	
  10B. DATED (SEE ITEM 13)

  
	
  CODE

  	
  FACILITY CODE

  	
  09/30/2003

  
												



 


11. THIS ITEM ONLY APPLIES TO
AMENDMENTS OF SOLICITATIONS


 


o The above numbered solicitation is
amended as set forth in Item 14.  The
hour and date specified for receipt of Offers o is
extended, ois not extended.


 


Offers must acknowledge
receipt of this amendment prior to the hour and date specified in the
solicitation or as amended, by one of the following methods:  (a) By completing Items 8 and 15, and
returning
             copies
of the amendment; (b) By acknowledging receipt of this amendment on each
copy of the offer submitted; or (c) By separate letter or telegram which
includes a reference to the solicitation and amendment numbers.  FAILURE OF YOUR ACKNOWLEDGEMENT TO BE
RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR
AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER.  If by virtue of this amendment, you desire to
change an offer already submitted, such change may be made by telegram or
letter, provided each telegram or letter makes references to the solicitation
and this amendment, and is received prior to the opening hour and date
specified.


 


12. ACCOUNTING AND
APPROPRIATION DATA (If required)


EIN  1-900216013-A1    SOCC#
25.55               CAN 
6-846701                                    [***]


 


13. THIS ITEM APPLIES ONLY TO
MODIFICATIONS OF CONTRACTS/ORDERS, IT MODIFIES THE CONTRACT/ORDER NO. AS
DESCRIBED IN ITEM 14.


 


	
   

  	
  A.

  	
  THIS CHANGE
  ORDER IS ISSUED PURSUANT TO:  (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE
  MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.

   

  
	
   

  	
  B.

  	
  THE
  ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE
  CHANGES (such as changes in paying office, appropriation
  date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR
  43.103(b).

   

  
	
   

  	
  C.

  	
  THIS
  SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:

  
	
  x

  	
  D.

  	
  OTHER
  (Specify type of modification and authority)

  P.L.
  1.602-1; Limitation of Cost Clause and P.L. 109-149

   

  
	
  E.           IMPORTANT:  Contractor o is not, x is required to sign this document and
  return 2 copies to the issuing office.

   

  
	
  14.  DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract
  subject matter where feasible)

  
	
  PURPOSE: 
  To increase the Total Estimated Cost of the contract and obligate
  funds in the amount of the increase.

  



 


	
   

  	
   

  	
  Total
  Funds Currently Allotted

  	
   

  	
  Total
  Estimated Cost

  	
   

  
	
   

  	
   

  	
  Cost

  	
   

  	
  Fee

  	
   

  	
  Total

  	
   

  	
  Cost

  	
   

  	
  Fee

  	
   

  	
  Total

  	
   

  
	
  Total Prior to this Mod:

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
  This Mod #

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
  Revised Total

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  



 


	
  COMPLETION DATE:  [***]

  
	
  FUNDED THROUGH:  [***]

  
	
   

  
	
  Except as provided
  herein, all terms and conditions of the document referenced in Item 9A or
  10A, as heretofore changed, remains unchanged and in full force and effect.

   

  
	
  15A.  NAME AND TITLE OF SIGNER (Type or print)

  	
  16A.  NAME AND TILE OF CONTRACTING OFFICER (Type or print)

  
	
  [***]

  	
   

  
	
   

  	
   

  
	
   

  	
   

  
	
  15B.  CONTRACTOR/OFFEROR

  	
  15C.  DATE SIGNED

  	
  16B.  UNITED STATES OF AMERICA

  	
  16C.  DATE SIGNED

  
	
  [***]

  	
  30 August 2006

  	
  [***]

   

  	
  [***]

  
	
   

  	
   

  	
  BY

  	
   

  	
   

  
	
  (Signature
  of person authorized to sign)

  	
   

  	
   

  	
  (Signature
  of Contracting Officer)

  	
   

  
	
   

  	
   

  	
   

  
	
  NSN 7540-01-152-8070

  PREVIOUS EDITION UNUSABLE 

  	
  30-105

  Computer
  Generated

  	
  STANDARD FORM 30 (REV.
  10-83

  Prescribed by GSA

  FAR (48 CFR)
  53.243

  
						



 

















 


	
  CONTRACT No: N01-AI-30052

  	
  SPECIAL PROVISIONS

  	
  Page 2 of 4

  
	
  Modification No: 08

  



 


ARTICLE
B.2.  ESTIMATED COST AND FIXED FEE,
paragraphs a., c., d., and e., are hereby modified to read as follows:


 


	
  a.

  	
   

  	
  The
  estimated cost of this contract is increased by [***] from [***] to [***].

  
	
   

  	
   

  	
   

  
	
  c.

  	
   

  	
  The
  Government’s obligation, represented by the sum of the estimated cost plus
  fixed fee, is increased [***] from [***] to [***].

  
	
   

  	
   

  	
   

  
	
  d.

  	
   

  	
  Total funds
  currently available for payment and allotted to this contract are hereby
  increased by [***] from [***] to [***]; of which [***] represents an increase
  to the estimated cost from [***] to [***] and of which [***] represents and
  increase to the fixed fee remaining unchanged at [***] For further provisions
  on funding, see the LIMITATION OF COST Clause referenced in Part II,
  ARTICLE 1.1., General Clauses for a Cost-Reimbursement Research and
  Development Contract.

  
	
   

  	
   

  	
   

  
	
  e.

  	
   

  	
  It is
  estimated that the amount currently allotted will cover performance through
  contract completion.

  



 


ARTICLE
B.3.  ADVANCE UNDERSTANDINGS,
paragraphs h., is hereby modified to revise the submilestone estimated cost,
fixed fee and total cost plus fixed fee detail as follows (all other aspect and
descriptions of the milestone chart remains inchanged):


 


	
  Milestone

  	
   

  	
  Submilestone

  	
   

  	
  Estimated

  Cost

  	
   

  	
  Fixed

  Fee

  	
   

  	
  Total

  CPFF

  	
   

  
	
  [***]

  	
   

  	
   

  	
   

  	
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  [***]

  	
   

  	
   

  	
   

  	
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  [***]

  	
   

  	
   

  	
   

  	
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  [***]

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  	
   

  



 


HHS-556


 

















 


	
  CONTRACT No: N01-AI-30052

  	
  SPECIAL PROVISIONS

  	
  Page 3 of pages 4

  
	
  Modification No: 08

  



 


	
   

  	
   

  	
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HHS-556


 

















 


	
  CONTRACT No: N01-AI-30052

  	
  SPECIAL PROVISIONS

  	
  Page 4 of pages 4

  
	
  Modification No: 08

  	
   

  	
   

  



 


ARTICLE H.6. CONTINUED BAN ON FUNDING OF HUMAN EMBRYO RESEARCH,
paragraph b. is hereby modified to add the following:


 


	
  b.

  	
  Public Law and Section No.

  	
   

  	
  Fiscal Year

  	
   

  	
  Period Covered

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  P.L. 109-149, Title V - General Provisions, Section 509

  	
   

  	
  2006

  	
   

  	
  10/01/05-09/30/06

  	
   

  



 


ARTICLE H.7.  NEEDLE EXCHANGE, paragraph b. is hereby modified to
add the following:


 


	
  b.

  	
  Public Law and Section No.

  	
   

  	
  Fiscal Year

  	
   

  	
  Period Covered

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  P.L. 109-149, Title V - General Provisions, Section 505

  	
   

  	
  2006

  	
   

  	
  10/01/05-09/30/06

  	
   

  



 


ARTICLE H.12. SALARY RATE LIMITATION LEGISLATION PROVISIONS,
paragraphs b. and c. are hereby modified to add the following:


 


	
  b.

  	
  Public Law No.

  	
   

  	
  Fiscal Year

  	
   

  	
  Dollar Amount of Salary Limitation*

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  P.L. 109-149

  	
   

  	
  2006

  	
   

  	
  Executive Level I

  	
   

  



 


	
  c.

  	
   

  	
  Payment of
  direct salaries is limited to the Executive Level I* rate which was in effect
  on the date(s) the expense was incurred.

  



 






	
  *

  	
  For the
  period 10/1/05 - 12/31/05, the Executive Level I rate is $180,100. Effective
  January 1, 2006, the Executive Level I rate increased to $183,500 and
  will remain at that rate until it is revised. See the web site listed below
  for the Executive Schedule rates of pay:

  



 


FOR FY06 EXECUTIVE LEVEL SALARIES EFFECTIVE JANUARY 1, 2006:


 


http://www.opm.gove/oca/06tables/html/ex.asp


 


(Note:  This
site shows the FY-06 rates. For previous years, click on “salaries and wages”
and then scroll down to the bottom of the page and click on the year to
locate the desired Executive Level salary rates.)


 


NOTE:        All prior Public Laws and
related Executive Levels incorporated in the Basic Award and all previous
Modifications shall remain in effect for the applicable fiscal year and related
funds.


 


ARTICLE H.14. PRESS RELEASES, paragraph b., is
hereby modified to add the following:


 


	
  b.

  	
  Public Law and Section No.

  	
   

  	
  Fiscal Year

  	
   

  	
  Period Covered

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  P.L. 109-149, Title V - General Provisions, Section 506

  	
   

  	
  2006

  	
   

  	
  10/01/05-09/30/06

  	
   

  



 


ARTICLE H.16. ANTI-LOBBYING, paragraph c., is
hereby modified to add the following:


 


	
  b.

  	
  Public Law and Section No.

  	
   

  	
  Fiscal Year

  	
   

  	
  Period Covered

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  P.L. 109-149, Title V - General Provisions, Section 503a

  	
   

  	
  2006

  	
   

  	
  10/01/05-09/30/06

  	
   

  
	
   

  	
  P.L. 109-149, Title V - General Provisions, Section 503b

  	
   

  	
  2006

  	
   

  	
  10/01/05-09/30/06

  	
   

  



 


HHS-556


 
















 


	
  AMENDMENT OF
  SOLICITATION/MODIFICATION OF CONTRACT

  	
  1.  CONTRACT ID CODE

  N/A

  	
  PAGE OF PAGES

  
	
  1

  	
  2

   

  
	
  2.  AMENDMENT/MODIFICATION NO

  	
  3.  EFFECTIVE DATE

  	
  4.  REQUISITION/PURCHASE REQ. NO.

  	
  5.  PROJECT NO. (If applicable)

  
	
  09

  	
  [See block 16C, below]

  	
   

  	
  N/A

  
	
   

  	
   

  	
   

  	
   

  
	
  ISSUED BY

  	
  CODE

  	
   

  	
  7.  ADMINISTERED BY (If other
  than Item 6)

  	
  CODE

  	
      N/A

  
	
   

  National Institutes of
  Health, HHS

  National Institute of
  Allergy and Infectious Diseases

  DEA, Contract Management
  Branch

  6700-B Rockledge Drive

  Room 3214, MSC 7612

  Bethesda, MD 20892-7612

   

  	
  MID RCB-B

  
	
   

  
	
  8. NAME AND ADDRESS OF
  CONTRACTOR (No., street, county, State and ZIP Code)

  	
  x

  	
  9A. AMENDMENT OF
  SOLICITATION NO.

  
	
   

  
	
  Avacia Limited

  PO Box 42, Hexagon House

  Blackley, Manchester, M9
  8ZS, UK

  	
   

  	
  9B. DATED (SEE ITEM 11)

  
	
   

  	
  x

  	
  10A.
  MODIFICATION OF CONTRACT/ORDER NO.

  
	
   

  	
  N01-AI-30052

   

  
	
   

  	
  10B. DATED (SEE ITEM 13)

  
	
  CODE

  	
  FACILITY CODE

  	
  09/30/2003

  
											



 


11. THIS ITEM ONLY APPLIES TO
AMENDMENTS OF SOLICITATIONS


 


o The above numbered solicitation is
amended as set forth in Item 14.  The
hour and date specified for receipt of Offers o is
extended, o is not extended.


 


Offers must acknowledge
receipt of this amendment prior to the hour and date specified in the
solicitation or as amended, by one of the following methods:  (a) By completing Items 8 and 15, and
returning copies of the amendment; (b) By acknowledging receipt of this
amendment on each copy of the offer submitted; or (c) By separate letter
or telegram which includes a reference to the solicitation and amendment
numbers.  FAILURE OF YOUR ACKNOWLEDGEMENT
TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE
HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER.  If by virtue of this amendment, you desire to
change an offer already submitted, such change may be made by telegram or
letter, provided each telegram or letter makes references to the solicitation
and this amendment, and is received prior to the opening hour and date
specified.


 


12. ACCOUNTING AND
APPROPRIATION DATA (If required)


EIN  1-900216013-A1; SOCC 25-55


 


13. THIS ITEM APPLIES ONLY TO
MODIFICATIONS OF CONTRACTS/ORDERS, IT MODIFIES THE CONTRACT/ORDER NO. AS
DESCRIBED IN ITEM 14.


 


	
   

  	
  A.

  	
  THIS
  CHANGE ORDER IS ISSUED PURSUANT TO:  (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE
  MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.

   

  
	
   

  	
  B.

  	
  THE
  ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE
  CHANGES (such as changes in paying office, appropriation
  date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR
  43.103(b).

   

  
	
   

  	
  C.

  	
  THIS
  SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:

  
	
  x

  	
  D.

  	
  OTHER
  (Specify type of modification and authority)

  P.L.
  1.602-1; Limitation of Cost Clause and P.L. 109-149

   

  
	
  E.         IMPORTANT:  Contractor o is not, x is required to sign this document and
  return 2 copies to the issuing office.

   

  
	
  14.  DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract
  subject matter where feasible)

  
	
  PURPOSE:  Modify Invoice Payment Procedures under
  ARTICLE G.3.

   

  
	
  COMPLETION DATE:  [***]

  	
  FUNDED THROUGH:  [***]

  
	
   

  
	
  Except as provided
  herein, all terms and conditions of the document referenced in Item 9A or
  10A, as heretofore changed, remains unchanged and in full force and effect.

   

  
	
  15A.  NAME AND TITLE OF SIGNER (Type or print)

  	
  16A.  NAME AND TILE OF CONTRACTING OFFICER (Type or print)

  
	
  [***]

  	
  [***]

  
	
  [***]

  	
  [***]

  
	
   

  	
   

  
	
  15B.  CONTRACTOR/OFFEROR

  	
  15C.  DATE SIGNED

  	
  16B.  UNITED STATES OF AMERICA

  	
  16C.  DATE SIGNED

  
	
  [***]

  	
  14JUN07

  	
  [***]

   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  BY

  	
   

  	
   

  
	
  (Signature of person authorized to sign)

  	
   

  	
   

  	
  (Signature
  of Contracting Officer)

  	
   

  
	
   

  	
   

  	
   

  
	
  NSN 7540-01-152-8070

  PREVIOUS EDITION UNUSABLE 

  	
  30-105

  Computer
  Generated

  	
  STANDARD FORM 30 (REV.
  10-83

  Prescribed by GSA

  FAR (48 CFR)
  53.243

  
									



 

















 


	
  CONTRACT
  No. N01-AI-30052

  	
  SPECIAL PROVISIONS

  	
  Page 2 of 2

  
	
  Modification
  No. 9

  



 


ARTICLE
G.3.      INVOICE SUBMISSION/CONTRACT
FINANCING REQUEST AND CONTRACT FINANCIAL REPORT - is hereby modified to read as
follows:


 


	
  a.

  	
   

  	
  Invoice/Financing
  Request Instructions and Contract Financial Reporting for NIH
  Cost-Reimbursement Type Contracts NIH(RC)-4 are attached and made part of
  this contract. The Contractor shall follow the attached instructions and
  submission procedures specified below to meet the requirements of a “proper
  invoice” pursuant to FAR Subpart 32.9, Prompt Payment.

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
  (1)

  	
  Payment
  requests shall be submitted as follows:

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
  On original to follow designated billing
  office:

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
  National
  Institutes of Health

  
	
   

  	
   

  	
   

  	
   

  	
  Office of
  Financial Management

  
	
   

  	
   

  	
   

  	
   

  	
  Commercial
  Accounts

  
	
   

  	
   

  	
   

  	
   

  	
  2115 East
  Jefferson Street, Room 4b-432, MSC 8500

  
	
   

  	
   

  	
   

  	
   

  	
  Bethesda, MD
  20892-8500

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
  (2)

  	
  In addition
  to the requirements specified in FAR Subpart 32.9 for a proper invoice, the
  Contractor shall include the following information on all payment request:

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
  (a)

  	
  Name of the
  Office of Acquisitions. The Office of Acquisitions for this contract is NIAID.

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
  (b)

  	
  Central
  Point of Distribution. For the purpose of this contract, the Central Point of
  Distribution is NIAID  OA  Invoices.

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
  (c)

  	
  Vendor
  Identification Number. This is the 7 digit number that appears after the
  Contractors name in Block 7 of Standard Form 26. (Note: This
  only applies to new contracts awarded on/after June 4, 2007, and any
  existing contract modified to include the number.)

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
  (d)

  	
  DUNS number
  or DUNS+4 that identifies the Contractor’s name and address exactly as stated
  on the face page of the contract.

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
  (e)

  	
  Identification
  of whether payment is to be made using a two-way or three-way match. This
  contract requires a two-way
  match.

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  b.

  	
   

  	
  Inquiries
  regarding payment shall be directed to the designated billing office, (301)
  496-6088.

  



 


SECTION J
- Attachment 2, Invoice/Financing Request Instructions and Contract Financial
Reporting for NIH Cost-Reimbursement Type Contracts NIH(RC)-4 is hereby
replaced with the following updated attachment.


 


HHS-556


 
















 


INVOICE/FINANCING REQUEST AND CONTRACT FINANCIAL REPORTING

INSTRUCTIONS FOR NIH COST-REIMBURSEMENT CONTRACTS, NIH(RC)-4


 


Format: 
Payment requests shall be submitted on the Contractor’s self-generated
form in the manner and format prescribed herein and as illustrated in the
Sample Invoice/Financing Request. Standard Form 1034, Public Voucher for
Purchases and Services Other Than Personal, may be used in lieu of the
Contractor’s self generated form provided it contains all of the information
shown on the Sample Invoice/ Financing Request. DO NOT include a cover letter
with the payment request.


 


Number of Copies: 
Payment requests shall be submitted in the quantity specified in the
Invoice Submission Instructions in Section G of the Contract Schedule.


 


Frequency: 
Payment requests shall not be submitted more frequently than once every
two weeks in accordance with the Allowable Cost and Payment Clause incorporated
into this contract. Small business concerns may submit invoices/financing
requests more frequently than every two weeks when authorized by the
Contracting Officer.


 


Cost Incurrence Period:  Costs
incurred must be within the contract performance period or covered by
precontract cost provisions.


 


Billing of Costs Incurred:  If
billed costs include (1) costs of a prior billing period, but not
previously billed, or (2) costs incurred during the contract period and
claimed after the contract period has expired, the Contractor shall site the
amount(s) and month(s) in which it incurred such costs.


 


Contractor’s Fiscal Year:  Payment requests shall be
prepared in such a manner that Government can identify costs claimed with the
Contractor’s fiscal year.


 


Currency:  All
NIH Contracts are expressed in United States dollars. When the Government pays
in a currency other than United States dollars, billings shall be expressed,
and payment by the Government shall be made, in that other currency at amounts
coincident with actual costs incurred. Currency fluctuations may not be a basis
of gain or loss to the Contractor. Notwithstanding the above, the total of all
invoices paid under this contract may not exceed the United States dollars
authorized.


 


Costs Requiring Prior Approval:  Costs
requiring the Contracting Officer’s approval, which are not set forth in an
Advance Understanding in the contract, shall be identified and reference the
Contracting Officer’s Authorization (COA) Number. In addition, the Contractor
shall show any cost set forth in Advance Understanding as a separate line item
on the payment request.


 


Invoice/Financing Request
Identification:  Each payment request shall be identified as
either:


 


(a)                                  Interim Invoice/Contract Financing Request:  These
are interim payment requests submitted during the contract performance period.


 


(b)                                 Completion Invoice:  The completion invoice shall be submitted
promptly upon completion of the work, but no later than one year from the
contract completion date, or within 120 days after settlement of the final
indirect cost rates covering the year in which the contract is physically
complete (whichever date is later). The Contractor shall submit the completion
invoice when all costs have been assigned to the contract and it completes all
performance provisions.


 


(c)                                  Final Invoice:  A final invoice may be required after the
amounts owed have been settled between the Government and the Contractor (e.g.,
resolution of all suspensions and audit exceptions).


 


Preparation and Itemization
of the Invoice/Financing Request:  The Contractor shall furnish
the information set forth in the instructions below. The instructions are keyed
to the entries on the Sample Invoice/Financing request.


 


(a)                                  Designated Billing Office Name and Address:  Enter
the designated billing office name and address, as identified in the Invoice
Submission Instructions in Section G of the Contract Schedule.


 


(b)                                 Contractor’s Name, Address, Point of contact, VIN, and DUNS or DUNS+4
Number:  Show the Contractor’s name and address
exactly as they appear in the contract, along with the name, title, 


 


	
  NIH(RC)-4

  	
   

  	
  ATTACHMENT 2

  
	
  Rev. 05/2007

  	
   

  	
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phone number, and e-mail
address of the person to notify in the event of an improper invoice or, in the
case of payment by method other than Electronic Funds Transfer, to whom payment
is to be sent. Provide the Contractor’s Vendor Identification Number (VIN), and
Data Universal Numbering System (DUNS) number or DUNS+4.  The DUNS number must identify the Contractor’s
name and address exactly as stated on the face page of the contract. When
an approved assignment has been made by the Contractor, or a different payee
has been designated, provide the same information for the payee as is required
for the Contractor (i.e., name, address, point of contract, VIN, and DUNS).


 


(c)                                  Invoice/financing Request Number:  Insert the appropriate serial
number of the payment request.


 


(d)                                 Date Invoice/Financing Request Prepared: 
Insert the date the payment request is prepared.


 


(e)                                  Contract Number and Order Number (if applicable): 
Insert the contract number and order number (if applicable).


 


(f)                                    Effective Date: 
Insert the effective date of the contract or if billing under an order,
the effective date of the order.


 


(g)                                 Total Estimated Cost of Contract/Order: 
Insert the total estimated cost of the contract, exclusive of fixed-fee.
If billing under an order, insert the total estimated cost of the order,
exclusive of fixed-fee. For incrementally funded contracts/orders, enter the
amount currently obligated and available for payment.


 


(h)                                 Total Fixed-Fee:  Insert the total fixed-fee (where
applicable). For incrementally funded contracts/orders, enter the amount
currently obligated and available for payment.


 


(i)                                     Two-Way/Three-Way Match: 
Identify whether payment is to be made using a two-way or three-way
match.  To determine required payment
method, refer to the Invoice Submission Instructions in Section G of the
Contract Schedule.


 


(j)                                     Office of Acquisitions: 
Insert the name of the office of Acquisitions, as identified in the
Invoice Submission Instruction in Section G of the Contract Schedule.


 


(k)                                  Central Point of Distribution:  Insert the Central Point of
Distribution, as identified in the Invoice Submission Instructions in Section G
of the Contract Schedule.


 


(l)                                     Billing Period: 
Insert the beginning and ending dates (month, day, and year) of the
period in which costs were incurred and for which reimbursement is claimed.


 


(m)                               Amount Billed - Current Period:  Insert the amount claimed for
the current billing period by major cost element, including any adjustments and
fixed-fee. If the Contract Schedule contains separately priced line items,
identify the contract line item(s) on the payment request and include a
separate breakdown (by major cost element) for each line item.


 


(n)                                 Amount Billed - Cumulative:  Insert the cumulative amounts
claimed by major cost element, including any adjustments and fixed-fee. If the
Contract Schedule contains separately priced line items, identify the contract
line item(s) on the payment request and include a separate breakdown (by
major cost element) for each line item.


 


(o)                                 Direct Costs:  Insert the major cost elements. For each
element, consider the application of the paragraph entitled “Costs Requiring
Prior Approval” on page 1 of these instructions.


 


(1)                                  Direct Labor:  Include salaries and wages paid (or accrued)
for direct performance of the contract.


 


For Level of Effort contracts only, the
Contractor shall provide the following information on a separate sheet of paper
attached to the payment request:


 


· hours or percentage of effort and cost by
labor category (as specified in the Level of Effort Article in Section F
of the contract) for the current billing period, and


 


	
  NIH(RC)-4

  	
   

  	
  ATTACHMENT 2

  
	
  Rev. 05/2007

  	
   

  	
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· hours or percentage of effort and cost by
labor category from contract inception through the current billing period.
(NOTE:  The Contracting Officer may
require the Contractor to provide additional breakdown for direct labor, such
as position title, employee name, and salary or hourly rate)


 


(2)                                  Fringe Benefits:  List any fringe benefits applicable to direct
labor and billed as a direct cost. Do not include in this category fringe
benefits that are included in indirect costs.


 


(3)                                  Accountable Personal Property:  Include permanent research
equipment and general purpose equipment having a unit acquisition cost of
$1,000 or more, with a life expectancy of more than two years, and sensitive
property regardless of costs (see the HHS contractor’s Guide for Control of
Government Property). Show permanent research equipment separate from general
purpose equipment.


 


On a separate sheet of paper attached to the
payment request, list each item for which reimbursement is request. An asterisk
(*) shall precede the item if the equipment is below the $1,000 approval level.
Include reference to the following (as applicable):


 


· item number for the specific piece of
equipment listed in the Property Schedule, and


 


· COA number, if the equipment is not covered
by the Property Schedule.


 


The Contracting Officer may require the
Contractor to provide further itemization of property having specific
limitations set forth in the contract.


 


(4)                                  Materials and Supplies:  Include equipment with unit costs of less
than $1,000 or an expected service life of two years or less, and consumable
material and supplies regardless of amount.


 


(5)                                  Premium Pay:  List remuneration in excess of the basic
hourly rate.


 


(6)                                  Consultant Fee:  List fees paid to consultants. Identify
consultant by name or category as set for in the contract or COA, as well as
the effort (i.e., number of hours, days, etc.) and rate billed.


 


(7)                                  Travel:  Include domestic and foreign travel. Foreign
travel is travel outside of Canada, the United States and its territories and
possessions, foreign travel means travel outside that country. Foreign travel
must be billed separately from domestic travel.


 


(8)                                  Subcontract Costs:  List subcontractor(s) by name and amount
billed.


 


(9)                                  Other:  List all other direct costs in total unless
exceeding $1,000 in amount. If over $1,000, list cost elements and dollar
amounts separately. If the contract contains restrictions on any cost element,
that cost element must be listed separately.


 


(p)                                 Cost of Money (COM):  Cite the COM factor and base in effect during
the time the cost was incurred and for which reimbursement is claimed.


 


(q)                                 Indirect Costs:  Identify the indirect cost base (IDC),
indirect cost rate, and amount billed for each indirect cost category.


 


(r)                                    Fixed-Fee:  Cite
the formula or method for computation or fixed-fee, if applicable. The
fixed-fee must be claimed as provided for by the contract.


 


(s)                                  Total Amounts Claimed:  insert the total amounts claimed for the
current and cumulative periods.


 


(t)                                    Adjustments: 
include amounts conceded by the Contractor, outstanding suspensions,
and/or disapprovals subject to appeal.


 


	
  NIH(RC)-4

  	
   

  	
  ATTACHMENT 2

  
	
  Rev. 05/2007

  	
   

  	
  Page 3

  



 

















 


(u)                                 Grand Totals


 


(v)                                 Certification of Salary Rate Limitation:  If
required by the contract (see Invoice Submission Instructions in Section G
of the Contract Schedule), the Contractor shall include the following
certification at the bottom of the payment request:


 


                                                “I herby certify that the salaries billed in
this payment request are in compliance with the Salary Rate Limitation
Provisions in Section H of the contract.”


 


The Contracting Officer may
require the Contractor to submit detailed support for costs claimed on one or
more interim payment requests.


 


FINANCIAL REPORTING INSTRUCTIONS:


 


These instructions are keyed to the Columns on
the sample invoice/financing request.


 


Column A - Expenditure Category:  Enter
the expenditure categories required by the contract.


 


Column B - Cumulative Percentage
of Effort/Hrs. - Negotiated:  Enter the percentage of effort
or number of hours agreed to for each employee or labor category listed in
Column A.


 


Column C - Cumulative Percentage
of Effort/Hrs. - Actual:  Enter the percentage of effort or number of
hours worked by each employee or labor category listed in Column A.


 


Column D - Amount Billed -
Current:  Enter amounts billed during the current
period.


 


Column E - Amount Billed -
Cumulative:  Enter the cumulative amounts to date.


 


Column F - Cost at Completion:  Enter
data only when the Contractor estimates that a particular expenditure category
will vary from the amount negotiated. Realistic estimates are essential.


 


Column G - Contract Amount:  Enter
the costs agreed to for all expenditure categories listed in Column A.


 


Column H - Variance (Over or
Under):  Show the difference between the estimated
costs at completion (Column F) and negotiated costs (Column G) when entries
have been made in Column F. This column need not be filled in when Column F is
blank. When a line item varies by plus or minus 10 percent, i.e., the
percentage arrived at by dividing Column F by Column G, an explanation of the
variance should be submitted. In the case of an overrun (net negative
variance), this submission shall not be deemed as notice under the Limitation
of Cost (Funds) Clause of the contract.


 


Modifications:  Any
modification i the amount negotiated for an item since the preceding report
should be listed in the appropriate cost category.


 


Expenditures Not Negotiated:  An
expenditure for an item for which no amount was negotiated (e.g., at the
discretion of the Contractor in performance of its contract) should be listed
in the appropriate cost category and all columns filled in, except for G.
Column H will of course show a 100 percent variance and will be explained along
with those identified under H above.


 


	
  NIH(RC)-4

  	
   

  	
  ATTACHMENT 2

  
	
  Rev. 05/2007

  	
   

  	
  Page 4

  



 

















 


SAMPLE
INVOICE/FINANCING REQUEST AND CONTRACT FINANCIAL REPORT


 


(a)          Designated
Billing Office Name and Address:


 


National Institutes of Health


Office of Financial Management


Commercial Accounts


2115 East Jefferson Street, Room 4B432, MSC 8500 


Bethesda, MD 20692-8500


 


(b)          Contractor’s
Name, Address, Point of Contact, VIN, and DUNS or DUNS+4 Number:


 


ABC CORPORATION


100 Main Street


Anywhere, USA Zip Code


Name, Title, Phone Number, and E-mail Address
of person to notify in the event of an improper invoice or, in the case of
payment by method other than Electronic Funds Transfer, to whom payment is to be
sent


VIN:


DUNS or DUNS+4




(c)                                  Invoice/Financing
Request No.:


 


(d)                                 Date
Invoice Prepared:


 


(e)                                  Contract
No. and Order No. (if
applicable):                


 


(f)                                    Effective
Date:


 


(g)                                 Total
Estimated Cost of Contract/Order:


 


(h)                                 Total
Fixed-Fee (if applicable):


 


(i)                                     o
Two-Way Match o Three-Way Match


 


(j)                                     Office
of Acquisitions:


 


(k)                                  Central
Point of Distribution:


 


(l)                                     This
invoice /financing request represents reimbursable costs for the period               
to                


 


	
   

  	
   

  	
  Cumulative Percentage of

  	
   

  	
  Amount Billed

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Effort/Hrs

  	
   

  	
   

  	
   

  	
  (n)

  	
   

  	
  Cost at

  	
   

  	
  Contract

  	
   

  	
   

  	
   

  
	
  Expenditure Category*

  	
   

  	
  Negotiated

  	
   

  	
  Actual

  	
   

  	
  (m) Current

  	
   

  	
  Cumulative

  	
   

  	
  Completion

  	
   

  	
  Amount

  	
   

  	
  Variance

  	
   

  
	
  A

  	
   

  	
  B

  	
   

  	
  C

  	
   

  	
  D

  	
   

  	
  E

  	
   

  	
  F

  	
   

  	
  G

  	
   

  	
  H

  	
   

  
	
  (o) Direct Costs:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (1) Direct Labor

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (2) Fringe Benefits

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (3) Accountable Property

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (4) Materials and Supplies

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (5) Premium Pay

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (6) Consultant Fees

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (7) Travel

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (8) Subcontracts

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (9) Other

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Total Direct Costs

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (p) Cost of Money

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (q) Indirect Costs

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (r) Fixed Fee

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (s) adjustments

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (t) adjustments

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (u) Grand Totals

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  



 


I certify that all payments are for
appropriate purposes and in accordance with the contract


 


	
   

  	
   

  	
   

  	
   

  
	
   

  	
  (Name of
  Official)

  	
   

  	
  (Title)

  



 






* Attach details as specified in the contract


 


	
  NIH(RC)-4

  	
   

  	
  ATTACHMENT 2

  
	
  Rev. 05/2007

  	
   

  	
  Page 5

  



 
















 


	
  AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

  	
  1.  CONTRACT ID CODE

  N/A

  	
  PAGE OF PAGES

  
	
  1

  	
  8

  



 


	
  2.  AMENDMENT/MODIFICATION NO

  	
  3.  EFFECTIVE DATE

  	
  4.  REQUISITION/PURCHASE REQ. NO.

  	
  5.  PROJECT NO. (If applicable)

  
	
  10

  	
  [see block 16C, below]

  	
  DMIO 2 017

  	
  N/A

  



 


	
  ISSUED BY

  	
  CODE

  	
   

  	
  7.  ADMINISTERED BY (If other
  than Item 6)

  	
  CODE

  	
  N/A

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  National Institutes of
  Health

  National Institute of Allergy and Infectious Diseases

  DEA, Contract Management Branch

  Room 3214 MSC 7612

  6700-B Rockledge Drive

  Bethesda, MD 20892-7612

  	
  MID2-RCB

  
	
   

  



 


	
  8. NAME AND ADDRESS OF
  CONTRACTOR (No., Street, county, State and ZIP Code)

  	
  o

  	
  9A. AMENDMENT OF
  SOLICITATION NO.

  
	
   

  
	
  Avecia Limited

  PO Box 42, Hexagon House

  Blackley, Manchester, M9
  8ZS, UK

  	
   

  	
  9B. DATED (SEE ITEM 11)

  
	
   

  	
   

  	
  x

  	
  10A. MODIFICATION OF
  CONTRACT/ORDER NO.

  
	
   

  	
   

  	
   

  	
  NO1-AI-30052

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  10B. DATED (SEE ITEM 13)

  
	
  CODE

  	
  FACILITY CODE

  	
   

  	
  09/30/2003

  



 


11. THIS ITEM ONLY APPLIES TO
AMENDMENTS OF SOLICITATIONS


 


oThe above numbered solicitation is amended as set forth
in Item 14.  The hour and date specified
for receipt of Offers         ois extended,  ois not extended


 


Offers must acknowledge
receipt of this amendment prior to the hour and date specified in the
solicitation or as amended, by one of the following methods:


 


(a) By completing
Items 8 and 15, and returning one (1) copy of the amendment; (b) By
acknowledging receipt of this amendment on each copy of the offer submitted; or
(c) By separate letter or telegram which includes a reference to the solicitation
and amendment numbers.  FAILURE OF YOUR
ACKNOWLEDGEMENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF
OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF
YOUR OFFER.  If by virtue of this
amendment, you desire to change an offer already submitted, such change may be
made by telegram or letter, provided each telegram or letter makes references
to the solicitation and this amendment, and is received prior to the opening
hour and date specified.


 


12. ACCOUNTING AND APPROPRIATION
DATA (If required)


EIN 1-900216013 - A1 SOCC 25.55


 


13. THIS ITEM APPLIES ONLY TO
MODIFICATIONS OF CONTRACTS/ORDERS,

IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.


 


	
  o

  	
  A.

  	
  THIS
  CHANGE ORDER IS ISSUED PURSUANT TO:  (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE
  MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.

  



 


	
   

  	
  B.

  	
  THE
  ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE
  CHANGES (such as changes in paying office, appropriation
  date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR
  43.103(b).

  



 


	
  x

  	
  C.

  	
  THIS SUPPLEMENTAL
  AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF: 

  P.L. 1.602-1

  



 


	
   

  	
  D.

  	
  OTHER
  (Specify type of modification and authority)

  



 


	
  E.             IMPORTANT:  Contractor o is not, x is required to sign this document and
  return 2 copies to the issuing office.

  



 


	
  14.  DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract
  subject matter where feasible)

  
	
   

  
	
  PURPOSE: 
  To increase the Total Estimated Cost and Fixed Fee; clarify Part B
  Statement and Work and the corresponding milestones; and to extend the
  contract completion date.

  



 


	
   

  	
   

  	
  TOTAL FUNDS ALLOTTED

  	
   

  	
  TOTAL ESTIMATED COST

  
	
  AMOUNT

  	
   

  	
  Cost

  	
   

  	
  Fee

  	
   

  	
  Total

  	
   

  	
  Cost

  	
   

  	
  Fee

  	
   

  	
  Total

  
	
  Prior to this
  Mod:

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
  This Mod #01:

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
  Revised TOTAL

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  



 


	
  FUNDED THROUGH DATE:

  	
   [***]

  	
  COMPLETION DATE:

  	
   [***]

  



 


	
  Except as provided
  herein, all terms and conditions of the document referenced in Item 9A or
  10A, as heretofore changed, remains unchanged and in full force and effect.

  
	
   

  
	
  15A.  NAME AND TITLE OF SIGNER (Type or print)

                             [***]

                             [***]

  	
  16A.  NAME AND TILE OF CONTRACTING OFFICER (Type or print)

                                                    
  [***]

                                                    
  [***]

  



 


	
  15B.  CONTRACTOR/OFFEROR
                              [***]

  	
  15C.  DATE SIGNED

  20 August 2007

  	
  16B.  UNITED STATES OF AMERICA

   

  	
  16C.  DATE SIGNED

  
	
   

  	
   

  	
   

  	
  BY

  	
   

  	
   

  	
   

  
	
  (Signature
  of person authorized to sign)

  	
   

  	
   

  	
   

  	
  (Signature of Contracting
  Officer)

  	
   

  
							



 


	
  NSN 7540-01-152-8070

  PREVIOUS EDITION
  UNUSABLE

  	
  30-105

  Computer Generated

  	
  STANDARD FORM 30
  (REV. 10-83)

  Prescribed by GSA

  FAR (48 CFR 53 243)

  



 

















 


	
  AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

  	
  1.  CONTRACT ID CODE

  N/A

  	
  PAGE OF PAGES

  
	
  1

  	
  8

  



 


	
  2.  AMENDMENT/MODIFICATION NO

  	
  3.  EFFECTIVE DATE

  	
  4.  REQUISITION/PURCHASE REQ. NO.

  	
  5.  PROJECT NO. (If applicable)

  
	
  10

  	
      [see block 16C, below]

  	
  DMIO 2 017

  	
  N/A

  



 


	
  ISSUED BY

  	
  CODE

  	
   

  	
  7.  ADMINISTERED BY (If other
  than Item 6)

  	
  CODE

  	
  N/A

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  National Institutes of
  Health

  National Institute of Allergy and Infectious Diseases

  DEA, Contract Management Branch

  Room 3214, MSC 7812

  6700-B Rockledge Drive

  Bethesda, MD 20892-7612

  	
  MID2-RCB

  
	
   

  



 


	
  8. NAME AND ADDRESS OF
  CONTRACTOR (No., Street, County, State and ZIP Code)

  	
  o

  	
  9A. AMENDMENT OF
  SOLICITATION NO.

  
	
   

  
	
  Avecia Limited

  PO Box 42, Hexagon House

  Blackley, Manchester, M9 8ZS, UK

  	
   

  	
  9B. DATED (SEE ITEM 11)

  
	
   

  	
   

  	
  x

  	
  10A. MODIFICATION OF
  CONTRACT/ORDER NO.

  
	
   

  	
   

  	
   

  	
  NO1-AI-30052

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  10B. DATED (SEE ITEM 13)

  
	
  CODE

  	
  FACILITY CODE

  	
  09/30/2003

  



 


11. THIS ITEM ONLY APPLIES TO
AMENDMENTS OF SOLICITATIONS


 


o The above numbered solicitation is amended as set
forth in Item 14.  The hour and date
specified for receipt of Offers          ois extended, ois not extended


 


Offers must acknowledge
receipt of this amendment prior to the hour and date specified in the
solicitation or as amended, by one of the following methods:


 


(a) By completing
Items 8 and 15, and returning one (1) copy of the amendment; (b) By
acknowledging receipt of this amendment on each copy of the offer submitted; or
(c) By separate letter or telegram which includes a reference to the
solicitation and amendment numbers. 
FAILURE OF YOUR ACKNOWLEDGEMENT TO BE RECEIVED AT THE PLACE DESIGNATED
FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT
IN REJECTION OF YOUR OFFER.  If by virtue
of this amendment, you desire to change an offer already submitted, such change
may be made by telegram or letter, provided each telegram or letter makes
references to the solicitation and this amendment, and is received prior to the
opening hour and date specified.


 


12. ACCOUNTING AND
APPROPRIATION DATA (If required)


EIN 1-900216013-A1 SOCC 25.55


 


13. THIS ITEM APPLIES ONLY TO
MODIFICATIONS OF CONTRACTS/ORDERS,

IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.


 


	
  o

  	
  A.

  	
  THIS
  CHANGE ORDER IS ISSUED PURSUANT TO:  (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE
  MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.

  



 


	
   

  	
  B.

  	
  THE
  ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE
  CHANGES (such as changes in paying office, appropriation
  date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR
  43.103(b).

  



 


	
  x

  	
  C.

  	
  THIS SUPPLEMENTAL
  AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:

  P.L. 1.602-1

  



 


	
   

  	
  D.

  	
  OTHER
  (Specify type of modification and authority)

  
	
   

  	
  E.

  	
  IMPORTANT:  Contractor o is not, x is required to sign this document and
  return 2 copies to the issuing office.

  



 


	
  14.  DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract
  subject matter where feasible)

  
	
  PURPOSE: 
  Fixed fee; clarify font B statement of Work and the corresponding
  miles tones; and to extend the contract completion date.

  



 


	
   

  	
   

  	
  TOTAL FUNDS ALLOTTED

  	
   

  	
  TOTAL ESTIMATED COST

  
	
  AMOUNT

  	
   

  	
  Cost

  	
   

  	
  Fee

  	
   

  	
  Total

  	
   

  	
  Cost

  	
   

  	
  Fee

  	
   

  	
  Total

  
	
  Prior to this
  MOD:

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
  This Mod #:

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
  Revised TOTAL

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  



 


	
  FUNDED THROUGH DATE:

  	
   

  	
  August 31, 2009
  (Unchanged)

  	
   

  	
  COMPLETION DATE:

  	
   

  	
  August 31, 2013
  (Unchanged)

  



 


	
  Except as provided
  herein, all terms and conditions of the document referenced in Item 9A or
  10A, as heretofore changed, remains unchanged and in full force and effect.

  



 


	
  15A.  NAME AND TITLE OF SIGNER (Type or print)

  [***]

  [***]

  	
  16A.  NAME AND TILE OF CONTRACTING OFFICER (Type or print)

  [***]

  [***]

  



 


	
  15B.  CONTRACTOR/OFFEROR

                                   [***]

  	
  15C.  DATE SIGNED

   

  	
  16B.  UNITED STATES OF AMERICA
                         [***]

  	
  16C.  DATE SIGNED

                    [***]

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  20 August 2007

  	
  BY

  	
   

  	
   

  	
   

  
	
  (Signature
  of person authorized to sign)

  	
   

  	
  (Signature of Contracting
  Officer)

  	
   

  
							



 


	
  NSN 7540-01-152-8070

  PREVIOUS EDITION
  UNUSABLE

  	
  30-105

  Computer Generated

  	
  STANDARD FORM 30
  (REV. 10-83)

  Prescribed by GSA

  FAR (48 CFR) 53.243

  



 

















 




	
  Contract
  No: N01-AI-30052

  Modification No: 10

  	
   

  	
  SPECIAL PROVISIONS

  	
   

  	
  Page 2 of 8

  






 


ARTICLE B.2.  ESTIMATED COST AND FIXED FEE,
- paragraphs a., b., and c. are hereby modified to read as follows:


 


a.                                       The
estimated cost of this contract is increased by [***] from  [***] to 
[***].


 


b.                                      The
fixed fee for this contract is increased by [***] from  [***] to 
[***].


 


c.                                       The
Government’s obligation, represented by the sum of the estimated cost plus
fixed fee, is increased by [***] from 
[***] to  [***].


 


ARTICLE
B.4.  ADVANCE UNDERSTANDINGS, paragraph
h., is hereby modified to revise the submilestone estimated cost, fixed fee,
total cost plus fixed fee, and clarification of the work to be completed per
milestone; detail as follows (all other aspects and descriptions of the
milestone chart remain unchanged):


 


	
   

  	
   

  	
  MILESTONES
  FOR AVECIA

  	
   

  	
  ESTIMATED
  

  COST

  	
   

  	
  FIXED
  FEE

  	
   

  	
  TOTAL
  

  CPFF

  
	
  4

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***] 

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***] 

  	
   

  	
   

  	
   

  	
  b) [***] 

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  5

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be
  paid in two installments for this milestone based on the completion of the
  following items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a) [***] 

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  



 

















 




	
  Contract
  No: N01-AI-30052

  Modification No: 10

  	
   

  	
  SPECIAL PROVISIONS

  	
   

  	
  Page 3 of 8

  






 


	
  6

  	
   

  	
  [***] 

  	
   

  	
  [***]

  	
   

  	
  [***]  

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be
  paid in three installments for this milestone based on the completion of the
  following items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***] 

  	
   

  	
   

  	
   

  	
  b) [***] 

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  7

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  8

  	
   

  	
  [***] 

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be
  paid in six installments for this milestone based on the completion of the
  following items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  f) [***]

  	
   

  	
   

  	
   

  	
  f) [***]

  	
   

  	
   

  



 

















 




	
  Contract
  No: N01-AI-30052

  Modification No: 10

  	
   

  	
  SPECIAL PROVISIONS

  	
   

  	
  Page 4 of 8

  






 


	
  10

  	
   

  	
  [***] 

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be
  paid in three installments for this milestone based on the completion of the
  following items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  f) [***]

  	
   

  	
   

  	
   

  	
  f) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  g) [***]

  	
   

  	
   

  	
   

  	
  g) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  h) [***]

  	
   

  	
   

  	
   

  	
  h) [***]

  	
   

  	
   

  



 

















 




	
  Contract
  No: N01-AI-30052

  Modification No: 10

  	
   

  	
  SPECIAL PROVISIONS

  	
   

  	
  Page 5 of 8

  






 


	
  11

  	
   

  	
  [***] 

  	
   

  	
  [***]

  	
   

  	
  [***]    

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be
  paid in five installments for this milestone based on the completion of the
  following items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***] 

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***] 

  	
   

  	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  	
   

  	
  d) [***] 

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  



 

















 




	
  Contract
  No: N01-AI-30052

  Modification No: 10

  	
   

  	
  SPECIAL PROVISIONS

  	
   

  	
  Page 6 of 8

  






 


	
  12

  	
   

  	
  [***] 

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be
  paid in two installments for this milestone based on the completion of the
  following items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  13

  	
   

  	
  [***] 

  	
   

  	
  [***]

  	
   

  	
  [***]    

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be
  paid in six installments for this milestone based on the completion of the
  following items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  	
   

  	
  d)
  [***]  

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  f) [***]

  	
   

  	
   

  	
   

  	
  f) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  14

  	
   

  	
  [***] 

  	
   

  	
  [***]

  	
   

  	
  [***]   

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be
  paid in three yearly installments for this milestone based on the completion
  of the following items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a)
  [***]  

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  



 

















 




	
  Contract
  No: N01-AI-30052

  Modification No: 10

  	
   

  	
  SPECIAL PROVISIONS

  	
   

  	
  Page 7 of 8

  






 


	
  15

  	
   

  	
  [***] 

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be
  paid in three equal installments (one each year) on provision of 

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  16

  	
   

  	
  [***] 

  	
   

  	
  [***]

  	
   

  	
  [***]    

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be
  paid in three installments (one each year) upon completion

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  f) [***]

  	
   

  	
   

  	
   

  	
  f) [***]

  	
   

  	
   

  



 

















 




	
  Contract
  No: N01-AI-30052

  Modification No: 10

  	
   

  	
  SPECIAL PROVISIONS

  	
   

  	
  Page 8 of 8

  






 


	
   

  	
   

  	
  g) [***]

  	
   

  	
   

  	
   

  	
  g) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  h) [***]

  	
   

  	
   

  	
   

  	
  h) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  i) [***]

  	
   

  	
   

  	
   

  	
  i) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  j) [***]

  	
   

  	
   

  	
   

  	
  j) [***]

  	
   

  	
   

  



 
















 


	
  AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

  	
  1.  CONTRACT ID CODE

  N/A

  	
  PAGE OF PAGES

  
	
  1

  	
  3

  



 


	
  2.  AMENDMENT/MODIFICATION NO

  	
  3.  EFFECTIVE DATE

  	
  4.  REQUISITION/PURCHASE REQ. NO.

  	
  5.  PROJECT NO. (If applicable)

  
	
  11

  	
       [see
  block 16C, below]

  	
  182712

  	
  N/A

  



 


	
  ISSUED BY

  	
  CODE

  	
   

  	
  7.  ADMINISTERED BY (If other
  than Item 6)

  	
  CODE

  	
       N/A

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  National Institutes of
  Health

  National Institute of
  Allergy and Infectious Diseases

  DEA, Contract Management
  Branch

  Room 3214, MSC 7612

  6700-B Rockledge Drive

  Bethesda, MD 20892-7612

  	
  MID2-RCB

  
	
   

  VIN:  1109979

  



 


	
  8. NAME AND ADDRESS OF
  CONTRACTOR (No., street, country, State and ZIP Code)

  	
  o

  	
  9A. AMENDMENT OF
  SOLICITATION NO.

  
	
   

  
	
  Avecia Limited

  PO Box 42, Hexagon House

  Blackley, Manchester, M9
  8ZS, UK

  	
   

  	
  9B. DATED (SEE ITEM 11)

  
	
   

  	
   

  	
  x

  	
  10A. MODIFICATION OF
  CONTRACT/ORDER NO.

  
	
   

  	
   

  	
   

  	
  N01-AI-30052

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  10B. DATED (SEE ITEM 13)

  
	
  CODE

  	
  FACILITY CODE

  	
  09/30/2003

  



 


11. THIS ITEM ONLY APPLIES TO
AMENDMENTS OF SOLICITATIONS


 


	
  o The above numbered solicitation is
  amended as set forth in Item 14. The hour and date specified for receipt of
  Offers       ois extended, ois not extended

  



 


	
  Offers must
  acknowledge receipt of this amendment prior to the hour and date specified in
  the solicitation or as amended, by one of the following methods:

   

  (a) By
  completing Items 8 and 15, and returning one (1) copy of the amendment;
  (b) By acknowledging receipt of this amendment on each copy of the offer
  submitted; or (c) By separate letter or telegram which includes a reference
  to the solicitation and amendment numbers. 
  FAILURE OF YOUR ACKNOWLEDGEMENT TO BE RECEIVED AT THE PLACE DESIGNATED
  FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED
  MAY RESULT IN REJECTION OF YOUR OFFER. 
  If by virtue of this amendment, you desire to change an offer already
  submitted, such change may be made by telegram or letter, provided each
  telegram or letter makes references to the solicitation and this amendment,
  and is received prior to the opening hour and date specified.

  



 


	
  12. ACCOUNTING AND
  APPROPRIATION DATA (If required)

  EIN 1-900216013-A1                              SOCC 25.55          CAN: 
  8475593      [***]

  



 


	
  13. THIS ITEM APPLIES ONLY TO
  MODIFICATIONS OF CONTRACTS/ORDERS,

  IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

  



 


	
  o

  	
  A.

  	
  THIS
  CHANGE ORDER IS ISSUED PURSUANT TO:  (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE
  MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.

  



 


	
   

  	
  B.

  	
  THE
  ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE
  CHANGES (such as changes in paying office, appropriation
  date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR
  43.103(b).

  



 


	
   

  	
  C.

  	
  THIS SUPPLEMENTAL
  AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:

  



 


	
  x

  	
  D.

  	
  OTHER (Specify type of modification and authority)

  FAR 1.602-1 and FAR
  52.232-11, Limitation of Funds

  



 


	
   

  	
  E.

  	
  IMPORTANT:  Contractor x is not, o is required to sign this document and
  return 2 copies to the issuing office.

  



 


	
  14.  DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract
  subject matter where feasible)

  
	
  PURPOSE: 
  The purpose of this modification is to add an increment of funds.

  



 


	
   

  	
   

  	
  TOTAL FUNDS ALLOTTED

  	
   

  	
  TOTAL ESTIMATED COST

  	
   

  
	
  AMOUNT

  	
   

  	
  Cost

  	
   

  	
  Fee

  	
   

  	
  Total

  	
   

  	
  Cost

  	
   

  	
  Fee

  	
   

  	
  Total

  	
   

  
	
  Total Prior to
  this MOD:

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
  MOD #01:

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
  TOTAL

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  



 


	
  FUNDED THROUGH DATE:

  	
  [***]

  	
  COMPLETION DATE:

  	
  [***]

  
	
   

  
	
  Except as provided
  herein, all terms and conditions of the document referenced in Item 9A or
  10A, as heretofore changed, remains unchanged and in full force and effect.

  



 


	
  15A.  NAME AND TITLE OF SIGNER (Type or print)

  	
  16A.  NAME AND TILE OF CONTRACTING OFFICER (Type or print)

  [***]

  [***]

  



 


	
  15B. CONTRACTOR/OFFEROR

  	
   

  	
  15C. DATE SIGNED

  	
  16B. UNITED STATES OF
  AMERICA

  	
   

  	
  16C. DATE SIGNED 

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
  BY

  	
  [***]

  	
   

  	
   

  
	
  (Signature
  of person authorized to sign)

  	
   

  	
   

  	
  (Signature
  of Contracting Officer)

  	
   

  	
   

  
							



 


	
  NSN 7540-01-152-8070

  PREVIOUS EDITION
  UNUSABLE

  	
  30-105

  Computer Generated

  	
  STANDARD FORM 30
  (REV. 10-83)

  Prescribed by GSA

  FAR (48 CFR) 53 243

  



 

















 


	
  Contract No:  N01-A1-30052

  Modification No:  11

  	
  SPECIAL
  PROVISIONS

  	
  Page 2 of 3

  



 


ARTICLE B.2.  ESTIMATED  COST AND FIXED FEE, - paragraphs d. and e., are hereby
modified to read as follows:


 


	
  d.

  	
  Total funds
  currently available for payment and allotted to this contract are hereby
  increased by [***] from [***] to [***]; of which [***] represents an increase
  to the estimated cost from [***] to [***]; and of which [***] represents an
  increase to the fixed fee from [***] to [***]. For further provisions on
  funding, see the LIMITATION OF FUNDS Clause referenced in Part II,
  ARTICLE I.1., General Clauses for a Cost-Reimbursement Research and
  Development Contract.

  
	
   

  	
   

  
	
  e.

  	
  It is
  estimated that the amount currently allotted will cover performance through
  January 31, 2011.

  



 


ARTICLE
H.6.  CONTINUED BAN ON FUNDING OF
HUMAN EMBRYO RESEARCH, paragraph b. is hereby
modified to add the following:


 


	
  b.

  	
  Public Law and Section No.

  	
   

  	
  Fiscal Year

  	
   

  	
  Period Covered

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  P.L.
  110-005, Section 509 *

  	
   

  	
  2007

  	
   

  	
  10/01/06 -
  09/30/07

  



 






	
   

  	
  *Public Law
  110-005, Revised Continuing Appropriations Resolution, 2007, extends the
  legislative provisions provided in the FY 2006 Appropriations Act (Public Law
  109-149) through the end of FY 2007.

  



 


ARTICLE
H.7.  NEEDLE EXCHANGE,
paragraph b. is hereby modified to add the following:


 


	
  b.

  	
  Public Law and Section No.

  	
   

  	
  Fiscal
  Year

  	
   

  	
  Period
  Covered

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  P.L.
  110-005, Section 505 *

  	
   

  	
  2007

  	
   

  	
  10/01/06 -
  09/30/07

  



 






	
   

  	
  *Public Law
  110-005, Revised Continuing Appropriations Resolution, 2007, extends the
  legislative provisions provided in the FY 2006 Appropriations Act (Public Law
  109-149) through the end of FY 2007.

  



 


ARTICLE
H.12.  SALARY RATE LIMITATION LEGISLATION PROVISIONS,
paragraphs b. and c. are hereby modified to add the following:


 


	
  b.

  	
  Public Law and No.

  	
   

  	
  Fiscal
  Year

  	
   

  	
  Dollar
  Amount of Salary Limitation*

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  P.L.
  110-005, Section 204 *

  	
   

  	
  2007

  	
   

  	
  Executive
  Level I

  



 






	
   

  	
  *Public Law 110-005, Revised Continuing Appropriations Resolution, 2007,
  extends the legislative provisions provided in the FY 2006 Appropriations Act
  (Public Law 109-149) through the end of FY 2007.  Therefore, the provision that restricts the
  amount of direct salary to Executive Level I of the Federal Executive Pay
  Scale continues through FY 2007.  The
  Executive Level I annual salary rate was $183,500 for the period January 1
  through December 31, 2006. 
  Effective January 1, 2007, the Executive Level I salary rate
  increased to $186,600.

  
	
   

  	
   

  
	
  c.

  	
  Payment of
  direct salaries is limited to the Executive I* rate which was in effect on
  the date(s) the expense was incurred.

  



 


HHS-556


 

















 


	
  Contract No:  N01-A1-30052

  Modification No:  11

  	
  SPECIAL
  PROVISIONS

  	
  Page 3 of 3

  



 


FOR FY -07 EXECUTIVE LEVEL
SALARIES EFFECTIVE JANUARY 1, 2007:


http://www.opm.gov/oca/07tables/html/ex.asp


(Note:  This site shows the FY-07 rates.  For previous years, click on “salaries and
wages” and then scroll down to the bottom of the pages and click on the
year to locate the desired Executive Level salary rates.)


 


	
  NOTE:

  	
  All prior Public Laws and related Executive Levels incorporated in
  the Basic Award and all previous Modifications shall remain in effect for the
  applicable fiscal year and related funds.

  



 


ARTICLE
H.14.  PRESS RELEASES,  paragraph b., is hereby modified to add the following:


 


	
  b.

  	
  Public Law and Section No.

  	
   

  	
  Fiscal
  Year

  	
   

  	
  Period
  Covered

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  P.L.
  110-005, Section 506 *

  	
   

  	
  2007

  	
   

  	
  10/01/06 -
  09/30/07

  



 






	
   

  	
  *Public Law
  110-005, Revised Continuing Appropriations Resolution, 2007, extends the
  legislative provisions provided in the FY 2006 Appropriations Act (Public Law
  109-149) through the end of FY 2007.

  



 


ARTICLE
H.16.  ANTI-LOBBYING,
paragraph c., is hereby modified to add the following:


 


	
  c.

  	
  Public Law and Section No.

  	
   

  	
  Fiscal
  Year

  	
   

  	
  Period
  Covered

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  for a.,
  above:  P.L. 110-005, Section 503(a)*

  	
   

  	
  2007

  	
   

  	
  10/01/06 -
  9/30/07

  
	
   

  	
  for b.,
  above:  P.L. 110-005, Section 503(b)*

  	
   

  	
  2007

  	
   

  	
  10/01/06 -
  9/30/07

  



 






	
   

  	
  *Public
  Law 110-005, Revised Continuing Appropriations Resolution, 2007, extends the
  legislative provisions provided in the FY 2006 Appropriations Act (Public Law
  109-149) through the end of FY 2007.

  



 


HHS-556


 

















 


[Letterhead of Department of Health and Human Services]


 


	
   

  	
  Division of Microbiology and Infectious Diseases

  
	
   

  	
  National Institute of Allergy and Infectious Diseases

  
	
   

  	
  Room 6111, 6610 Rockledge Drive

  
	
   

  	
  Bethesda, MD 20892-6603

  
	
   

  	
  Ph:  301-496-1884

  
	
  [***]

  	
   

  
	
  Avecia Biotechnology

  	
   

  
	
  PO Box 2, Belasis Avenue

  	
   

  
	
  Billingham

  	
   

  
	
  TS23 1 YN United Kingdom

  	
   

  
	
   

  	
   

  
	
  June 12, 2006

  	
   

  
	
   

  	
   

  
	
  Re: [***]

  
	
   

  	
   

  
	
  Dear Dr. Duchars,

  
	
   

  
	
  [***]

  
	
   

  
	
  [***]

  
	
  1. Not
  to further modify the CDC approved modified code

  2. To
  use the routines exclusively for government purposes within the scope of the
  DMID contract.

  3. To
  contact the CDC for a commercial use license in the event the routines are
  required for any private or commercial purposes.

  
	
   

  
	
  If Avecia Biotechnology agrees with the terms of this LoA please have
  an authorized signatory sign below.

  
	
   

  
	
  [***]

  
	
   

  
	
   

  
	
  [***]

  	
   

  
	
  [***]

  	
   

  
	
  Division of Microbiology and Infectious Diseases

  
	
   

  
	
  Accepted and Agreed on behalf of Avecia
  Biotechnology:

  
			



 


	
  [***]

  	
   

  	
  Date:

  	
  [***]

  
	
    [***]

  	
   

  	
   

  	
   

  
	
    [***]

  	
   

  	
   

  	
   

  



 

















 


[Letterhead of Department of Health and Human Services]


 


	
  [***]

  	
   

  
	
  Avecia Biotechnology

  	
  6610 Rockledge Dr

  
	
  Belasis Avenue

  	
  Room 5119

  
	
  Billingham, Cleveland

  	
  Bethesda, MD 20892-6604

  
	
  TS23 1YN, United Kingdom

  	
  Ph 301-451-4806

  
	
   

  	
  Fax 301-496-8030

  
	
   

  	
  swinram@niaid.nih.gov

  
	
   

  	
   

  
	
  RE: 
  Letter of Agreement - NIAID’s Clinical Trials using Avecia’s rPA
  Vaccine Candidate

  
	
   

  
	
  Dear Matthew,

  
	
   

  
	
  [***]

  
	
   

  
	
  [***]

  
	
   

  
	
  NIAID agrees that Avecia may have the following involvement in the
  DMID sponsored clinical trial:

  
	
   

  
	
  [***]

  



 


Data generated by studies using Avecia’s vaccine candidate will be
owned by NIAID but will be made available to Avecia, at no cost.  Once a clinical trial has been completed, the
data obtained may be published with the prior written permission of NIAID.  NIAID will provide Avecia an opportunity to
review and comment on proposed publications.


 


Please indicate your acceptance of these terms by having an authorized
representative from Avecia Biotechnology sign below.  At your earliest convenience, kindly return a
copy of this letter to my attention, and then please mail the signed original
using the contact information above.


 


	
   

  
	
  Sincerely,

  	
  Authorized Representative for Avecia Biotechnology:

  
	
   

  	
   

  
	
   

  	
  [***]  30th June 2004

  
	
  [***]

  	
  Signature & Date

  
	
  [***]

  	
   

  
	
  [***]

  	
  Name:

  	
  [***]

  
	
  [***]

  	
   

  	
   

  
	
  July 2, 2007

  	
  Title:

  	
  [***]

  



 
















 


	
  AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

  	
  1  CONTRACT ID CODE

  	
  PAGE OF PAGES

  
	
  N/A

  	
  1

  	
  2

   

  
	
  2  AMENDMENT/MODIFICATION NO

  	
  3  EFFECTIVE DATE

  	
  4  REQUISITION/PURCHASE REQ. NO.

  	
  5  PROJECT NO (If
  applicable)

  
	
  13

  	
  [see block 16C, below]

  	
   

  	
   

  	
  N/A

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  6  ISSUED BY

  	
  CODE

  	
   

  	
  7  ADMINISTERED BY (If other
  than Item 6)

  	
  CODE

  	
  N/A

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  National Institutes of
  Health

  National Institute of Allergy and Infectious Diseases

  DEA, Contract Management Branch

  Room 3214, MSC 7612

  5700-B Rockledge Drive

  Bethesda, MD 20892-7612

   

  	
  MID - RCB-B

  
	
   

  
	
  8.  NAME AND ADDRESS OF CONTRACTOR (No Street County State and ZIP Code)

  	
  x

  	
  9A.  AMENDMENT OF SOLICITATION NO

  
	
   

  
	
   

  	
  PharmAthene UK, Limited
  VIN:  1148448

  Johnson Matthey Building

  PO Box 88, Haverton Hill Road

  Billingham TS23 1XN

  	
   

  	
  9B.  DATED (SEE ITEM 11)

  
	
  x

  	
  10A.
  MODIFICATION OF CONTRACT/ORDER NO

  
	
  NO1-AI-30052

   

  
	
   

  	
  10B.  DATED (SEE ITEM 13)

  
	
  CODE

  	
  FACILITY CODE

  	
  09/30/2003

  
	
   

  
	
  11.  THIS ITEM ONLY APPLIES TO AMENDMENTS OF
  SOLICITATIONS

  
	
   

  
	
  o The above numbered solicitation is
  amended as set forth in Item 14.  The
  hour and date specified for receipt of Offers      o is extended,          o is not extended. 

   

  Offers must acknowledge receipt of this amendment
  prior to the hour and date specified in the solicitation or as amended, by
  one of the following methods:

   

  (a) By completing
  Items 8 and 15, and returning one (1) copy of the amendment; (b) By
  acknowledging receipt of this amendment on each copy of the offer submitted
  or (c) By separate letter or telegram which includes a reference to the
  solicitation and amendment numbers. 
  FAILURE OF YOUR ACKNOWLEDGEMENT TO BE RECEIVED AT THE PLACE DESIGNATED
  FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATA SPECIFIED MAY RESULT
  IN REJECTION OF YOUR OFFER.  If by
  virtue of this amendment you desire to change an offer already submitted,
  such change may be made by telegram or letter, provided each telegram or
  letter makes reference to the solicitation and this amendment, and is
  received prior to the opening hour and date specified

   

  
	
  12.  ACCOUNTING AND APPROPRIATION DATA (If required)

     SOCC 25.55

   

  
	
  13.  THIS ITEM APPLIES ONLY TO MODIFICATIONS OF
  CONTRACTS/ORDERS,

  IT MODIFIES THE CONTRACT/ORDER NO.  AS
  DESCRIBED IN ITEM 14.

   

  
	
  (C)

  	
  A.             THIS CHANGE ORDER IS ISSUED PURSUANT
  TO  (Specify
  authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE
  CONTRACT ORDER NO IN ITEM 10A.

   

  
	
   

  
	
   

  	
  B.              THE ABOVE NUMBERED CONTRACT/ORDER IS
  MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as
  changes in paying office, appropriation date, etc.)  SET FORTH IN ITEM 14, PURSUANT TO THE
  AUTHORITY OF FAR 43.103(b).

   

  
	
  x

  	
  C.                THIS
  SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:

  FAR 42,12 and FAR 1.502-1

  
																



 


	
   

  	
  D.             OTHER (Specify type of modification and
  authority)

   

  
	
  E. 
  IMPORTANT:  Contractor                o is not,  x 
  is required to sign this document and return 2 copies to the issuing
  office.

   

  
	
  14  DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract
  subject matter where feasible)

  
	
  PURPOSE: 
  To recognize the Contractor’s successor in Interest from Avecia
  Biologica Limited to Pharmothene UK, Limited, to revise ARTICLE B.4.  ADVANCED UNDERSTANDINGS and ARTICLE
  G.1.  PROJECT OFFICER.

  



	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Total Funds Currently Allotted

  	
   

  	
  Total Estimated Cost

  	
   

  
	
   

  	
   

  	
  Cost

  	
   

  	
  Fee

  	
   

  	
  Total

  	
   

  	
  Cost

  	
   

  	
  Fee

  	
   

  	
  Total

  	
   

  
	
  Prior to this Mod:

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  117,736,200

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  $

  	
  118,036,200

  	
   

  
	
  This Mod #

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  -0-

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  $

  	
  -0-

  	
   

  
	
  Revised Total

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  117,736,200

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  $

  	
  118,036,200

  	
   

  



	
   

  	
   

  
	
  FUNDED THROUGH
  DATE:  January 31, 2001
  (Unchanged)

  	
  COMPLETION
  DATE:  August 31, 2013 (Unchanged)

  
	
   

  
	
  Except as provided
  herein, all terms and conditions of the document referenced in Item 9A or
  10A, as heretofore changed, remains unchanged and in full force and effect.

  
	
   

  
	
  15A.  NAME AND TITLE OF SIGNER (Type or print)

  	
  16A.  NAME AND TITLE OF CONTRACTING OFFICER (Type or print)

  
	
  Chris Camut, VP, CFO/UK
  Board of Directors

  	
  Karen M. Gamble

  
	
  Contracting Officer,
  DEA, NIAID, HIH

  
	
   

  	
   

  
	
  15B.  CONTRACTOR/OFFEROR

  	
  15C.  DATE SIGNED

  	
  16B.  UNITED STATES OF AMERICA

  	
  16C.  DATE SIGNED

  
	
   

  	
  12/4/08

  	
   

  	
  12/4/08

  
	
  /s/
  Chris Camut

  	
   

  	
  BY

  	
  /s/
  Karen Gamble

  	
   

  
	
  (Signature of person authorized to sign)

  	
   

  	
   

  	
  (Signature
  of Contracting Officer)

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  NSN 7540-01-152-8070

  PREVIOUS EDITION UNUSABLE

  	
  30-105

  Computer Generated

  	
  STANDARD FORM 30
  (REV. 10-83)

  Prescribed by GRA

  FAR (48 CPR) 53.243

  
								



 

















 


	
  Contract No:  N01-A1-30052

  Modification No:  13

  	
  SPECIAL
  PROVISIONS

   

  	
  Page 2 of 2

  



 


Pursuant to FAR 42.12, Block 8 of the
Standard Form 30 shall read as follows:


 


PharmAthene
UK, Limited VIN: 1148448

Johnson Matthey Building

PO Box 88, Haverton Hill Road

Billingham TS23 1XN


 


The following is attached and made part of
this modification:


 


Novation
Agreement

Exhibit A, List of all Affected Contracts


 


ARTICLE B.4.  ADVANCED
UNDERSTANDINGS, paragraph g. Ceilings, is modified to add the following:


 


(8)              As a result of this
novation, it is agreed that the Total Estimated Cost of this Contract shall not
exceed the current value of $118,036,200, due to any variances in the indirect
costs.


 


ARTICLE G.1.  PROJECT OFFICER, is
modified to add the following:


 


The Alternate Project Officer named below will represent the Government
for the purpose of this contract:


 


Nancy Wilkie

Office of Biodefense Research Affairs (OBRA)

Division of Microbiology and Infectious Diseases

DHHS/NIH/NIAID

Room 5004, MSC 6604

6610 Rockledge Drive

Bethesda, MD  20892-6604

wilkien@niaid.nih.gov


 


	
  HHS-556

  



 

















 


NOVATION
AGREEMENT


 


AVECIA BIOLOGICS LIMITED
(Transferor), a corporation duly organized and existing under the laws of
England and Wales with its principal office in Manchester United Kingdom; PHARMATHENE UK LIMITED (Transferee), a corporation duly
organized and existing under the laws of England and Wales with its principal office
in Billingham, UK; and the UNITED STATES OF AMERICA
(Government) enter into this Agreement as of 2nd April, 2008.


 


(a)   The parties agree to the
following facts:


 


(1)   The Government, represented by various
Contracting Officers of the National Institute for Allergies and Infectious
Diseases, has entered into certain contracts with the Transferor as shown in
the attached list marked ‘Exhibit A’ and incorporated in this Agreement by
reference.  The term “the contracts,” as
used in this Agreement, means the above contracts and purchase orders and all
other contracts and purchase orders, including all modifications, made between
the Government and the Transferor before the effective date of this Agreement
(whether or not performance and payment have been completed and releases
executed if the Government or the Transferor has any remaining rights, duties,
or obligations under these contracts and purchase orders).  Included in the term “the contracts” are also
all modifications made under the terms and conditions of these contracts and
purchase orders between the Government and the Transferee, on or after the
effective date of this Agreement.


 


(2)   As of 2nd April, 2008, the Transferor has transferred to
the Transferee all the assets of the Transferor by virtue of a Sale and
Purchase Agreement between the Transferor and the Transferee.


 


(3)   The Transferee has acquired
all the assets of the Transferor by virtue of the above transfer.


 


(4)   The Transferee has assumed
all obligations and liabilities of the Transferor under the contracts by virtue
of the above transfer.


 


(5)   The Transferee is In a
position to fully perform all obligations that may exist under the contracts.


 


(6)   It is consistent with the
Government’s interest to recognize the Transferee as the successor party to the
contracts.


 


(7)   Evidence of the above transfer has been filed
with the Government.


 


(b)   In consideration of these
facts, the parties agree that by this Agreement—


 


(1)   The Transferor confirms the transfer to the
Transferee, and waives any claims and rights against the Government that it now
has or may have in the future in connection with the contracts.


 


(2)   The Transferee agrees to be bound by and to
perform each contract in accordance with the conditions contained in the
contracts.  The Transferee also


 

















 


assumes all obligations and liabilities of, and all claims against, the
Transferor under the contracts as if the Transferee were the original party to
the contracts.


 


(3)   The Transferee ratifies all previous actions
taken by the Transferor with respect to the contracts, with the same force and
effect as if the action had been taken by the Transferee.


 


(4)   The Government recognizes
the Transferee as the Transferor’s successor in interest in and to the
contracts.  The Transferee by this Agreement
becomes entitled to all rights, titles, and interests of the Transferor in and
to the contracts as if the Transferee were the original party to the
contracts.  Following the effective date
of this Agreement, the term “Contractor,” as used in the contracts, shall refer
to the Transferee.


 


(5)   Except as expressly provided
in this Agreement, nothing in it shall be construed as a waiver of any rights
of the Government against the Transferor.


 


(6)   All payments and
reimbursements previously made by the Government to the Transferor, and all
other previous actions taken by the Government under the contracts, shall be
considered to have discharged those parts of the Government’s obligations under
the contracts.  All payments and
reimbursements made by the Government after the date of this Agreement in the
name of or to the Transferor shall have the same force and effect as if made to
the Transferee, and shall constitute a complete discharge of the Government’s
obligations under the contracts, to the extent of the amounts paid or
reimbursed.


 


(7)   The Transferor and the
Transferee agree that the Government is not obligated to pay or reimburse
either of them for, or otherwise give effect to, any costs, taxes, or other
expenses, or any related increases, directly or indirectly arising out of or
resulting from the transfer or this Agreement, other than those that the
Government in the absence of this transfer or Agreement would have been
obligated to pay or reimburse under the terms of the contracts.


 


(8)   The Transferor guarantees payment of all
liabilities and the performance of all obligations that the Transferee—


 


(i)    Assumes under this
Agreement; or


 


(ii)   May undertake in the
future should these contracts be modified under their terms and
conditions.  The Transferor waives notice
of, and consents to, any such future modifications.


 


(9)   The contracts shall remain in full force and
effect, except as modified by this Agreement. 
Each party has executed this Agreement as of the day and year first
above written.


 


UNITED STATES OF AMERICA,


 


	
  Signed

  	
  [***]

  	
   

  
	
   

  	
   

  	
   

  
	
  Name and Title

  	
  [***]

  	
   

  



 

















 


AVECIA BIOLOGICS LIMITED,


 


	
  Signed

  	
  /s/ Duncan McLellan

  	
   

  
	
   

  	
   

  
	
  Name and Title

  	
  Duncan McLellan - Director and Chief
  Financial Officer

  



 


PHARMATHENE UK LIMITED,


 


	
  Signed

  	
  /s/ David P. Wright

  	
   

  
	
   

  	
   

  
	
  Name and Title

  	
  David P. Wright - CEO

  



 


CERTIFICATE


 


I, Richard Clements,
certify that I am the Company Secretary of AVECIA BIOLOGICS LIMITED, that
Duncan McLellan, who signed this Agreement for this corporation, was then a
Director and the Chief Financial Officer of this corporation; and that this
Agreement was duly signed for and on behalf of this corporation by authority of
its governing body and within the scope of its corporate powers.  Witness my hand this day of 2nd June 2008.


 


	
  Signed

  	
  /s/ Richard Clements

  	
   

  



 


CERTIFICATE


 


I, Christopher C. Camut,
certify that I am the Company Secretary of PHARMATHENE UK LIMITED, that
David P. Wright, who signed this Agreement for this corporation, was then
a Director of this corporation; and that this Agreement was duly signed for and
on behalf of this corporation by authority of its governing body and within the
scope of its corporate powers.  Witness
my hand this day of 23 June 2008.


 


	
  Signed

  	
  /s/ Christopher C. Camut

  	
   

  



 

















 


Exhibit A


 


The Contracts


 


Contract number N01-AI-25492


 


Contract
between Avecia Biologics Limited and the National Institute of Allergy and
Infectious Diseases (NIAID), part of the US National Institutes of Health
(NIH), for “Development and Testing of Vaccines Against Anthrax.”


 


Contract number N01-AI-30052


 


Contract
between Avecia Biologics Limited and the National Institute of Allergy and
Infectious Diseases (NIAID), part of the US National Institutes of Health
(NIH), for “Production and Testing of Anthrax Recombinant Protective Antigen.”


 


Contract number HHSN266200400034C, N01-AI-40034


 


Contract
between Avecia Biologics Limited and the National Institute of Allergy and
Infectious Diseases (NIAID), part of the US National Institutes of Health
(NIH), for “Development, Testing and Evaluation of Candidate Vaccines Against
Plague.”


 

















 


List of Affected Contracts


 


Contract number N01-AI-25492


 


Contract
between Avecia Biologics Limited and the National Institute of Allergy and
Infectious Diseases (NIAID), part of the US National Institutes of Health
(NIH), for “Development and Testing of Vaccines Against Anthrax.”


 


This contract
is substantially complete.  As at 15th January 2008, the total contract amount
was $10,155,120 and there was an [***] which is under discussion between Avecia
Biologics Limited and NIAID.


 


	
  Contracting
  Office:

  	
   

  	
  National
  Institutes of Health

  
	
   

  	
   

  	
  Office of
  Acquisitions, NIAID

  
	
   

  	
   

  	
  Room 3214

  
	
   

  	
   

  	
  6700-B
  Rockledge Dr., MSC 7612

  
	
   

  	
   

  	
  Bethesda,
  Maryland 20892-7612

  



 


Contract number N01-AI-30052


 


Contract
between Avecia Biologics Limited and the National Institute of Allergy and
Infectious Diseases (NIAID), part of the US National Institutes of Health
(NIH), for “Production and Testing of Anthrax Recombinant Protective Antigen.”


 


As at 15th April 2008, the total contract value was
$118,036,200 and the total estimated costs remaining to complete were [***].


 


	
  Contracting
  Office:

  	
   

  	
  National
  Institutes of Health

  
	
   

  	
   

  	
  Office of
  Acquisitions, NIAID

  
	
   

  	
   

  	
  Room 3214

  
	
   

  	
   

  	
  6700-B
  Rockledge Dr., MSC 7612

  
	
   

  	
   

  	
  Bethesda,
  Maryland 20892-7612

  



 


Contract number HHSN266200400034C, N01-AI-40034


 


Contract
between Avecia Biologics Limited and the National Institute of Allergy and
Infectious Diseases (NIAID), part of the US National Institutes of Health
(NIH), for “Development, Testing and Evaluation of Candidate Vaccines Against
Plague.”


 


As at 15th April 2008, the total contract value was
$50,701,714 and the total estimated costs remaining to complete were [***].


 


	
  Contracting
  Office:

  	
   

  	
  National
  Institutes of Health

  
	
   

  	
   

  	
  Office of
  Acquisitions, NIAID

  
	
   

  	
   

  	
  Room 3214

  
	
   

  	
   

  	
  6700-B
  Rockledge Dr., MSC 7612

  
	
   

  	
   

  	
  Bethesda,
  Maryland 20892-7612