Exhibit 10.47


 


	
  AMENDMENT
  OF SOLICITATION/MODIFICATION OF CONTRACT

  	
  1.        CONTRACT ID CODE

  	
  PAGE OF PAGES

  
	
   

  	
   

  	
  1

  	
  1

  
	
   

  	
   

  	
   

  	
   

  
	
  2.        AMENDMENT/MODIFICATION NO

  	
  3.   EFFECTIVE DATE

  	
  4.        REQUISITION/PURC

  	
  5.        PROJECT NO. (If
  applicable)

  
	
  Mod #01

  	
  See Block 16 C

  	
  N/A

  	
  N/A

  
	
   

  	
   

  	
   

  	
   

  
	
  6.        ISSUED BY

  	
  CODE

  	
   

  	
  7.        ADMINISTERED BY (If other
  than Item 6)

  	
  CODE

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  National Institutes of
  Health

  Contract Management Program, NIAID

  6700-B Rockledge Drive

  Room 3214, MSC 7612

  Bethesda, MD  20892-7612

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  
										



	
  8.

  	
  NAME AND ADDRESS OF CONTRACTOR (No., street,
  county, State and ZIP Code)

  	
  x

  	
  9A.    AMENDMENT OF SOLICITATION NO.

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  Avecia Limited

  	
   

  	
  9B.       DATED (SEE ITEM
  11)

  
	
   

  	
  P.O. Box 42,
  Hexagon House

  	
   

  	
   

  
	
   

  	
  Billingham TS23
  1YN, UK

  	
   

  	
   

  
	
   

  	
  Blackley,
  Manchester, M9 8ZS, UK

  	
  x

  	
  10A.   MODIFICATION OF CONTRACT/ORDER NO.

  
	
   

  	
   

  	
   

  	
  N01-AI-40034

  
	
   

  	
   

  	
   

  	
   

  
	
  CODE

  	
   

  	
  FACILITY CODE

  	
   

  	
  10B.    DATED (SEE ITEM 13)

  September 30, 2004

  
						



 


11.  THIS ITEM ONLY APPLIES TO AMENDMENTS OF
SOLICITATIONS


 


o The above numbered solicitation is
amended as set forth in Item 14.  The
hour and date specified for receipt of Offers o is
extended, o is not extended.


 


Offers must acknowledge
receipt of this amendment prior to the hour and date specified in the
solicitation or as amended, by one of the following methods:


 


(a) By completing
Items 8 and 15, and returning                   
copies of the amendment; (b) By acknowledging receipt of this amendment on
each copy of the offer submitted; or (c) By separate letter or telegram
which includes a reference to the solicitation and amendment numbers.  FAILURE OF YOUR ACKNOWLEDGEMENT TO BE
RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR
AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER.  If by virtue of this amendment, you desire to
change an offer already submitted, such change may be made by telegram or
letter, provided each telegram or letter makes reference to the solicitation
and this amendment, and is received prior to the opening hour and date
specified.


 


	
  12.     ACCOUNTING AND APPROPRIATION DATA (If required)

  
	
  EIN#:  1-900216013-A1

  	
  SOC#:  25.55

  	
  [***]

  
	
   

  	
   

  	
   

  
	
  13.     THIS ITEM APPLIES ONLY TO MODIFICATIONS
  OF CONTRACT/ORDERS, IT MODIFIES THE CONTRACT/ORDER
  NO. AS DESCRIBED IN ITEM 14.

  
	
   

  
	
  x

  	
  A.       THIS CHANGE ORDER IS ISSUED PURSUANT
  TO:  (Specify
  authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE
  CONTRACT ORDER NO. IN ITEM 10A.

  
	
   

  	
   

  
	
  x

  	
  B.       THE ABOVE NUMBERED CONTRACT/ORDER IS
  MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as
  changes in paying office, appropriate date, etc.) SET FORTH IN
  ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).

  
	
   

  	
   

  
	
   

  	
  C.       THIS SUPPLEMENTAL AGREEMENT IS ENTERED
  INTO PURSUANT TO AUTHORITY OF:

  
	
   

  
	
   

  	
  D.       OTHER (Specify
  type of modification and authority)

  
	
   

  
	
  E.        IMPORTANT:  Contractor x is not, o is required to sign this document and
  return          copies to the issuing
  office.

  
	
   

  
	
  14.     DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract
  subject matter where feasible)

  
	
   

  
	
  PURPOSE:  To deobligate funds on the Contract Award
  from the Common Account Number (CAN) 8421247.

  
	
   

  
	
  TOTAL AMOUNT
  FUNDED:  [***]

  
	
  TOTAL ESTIMATED
  COST:  [***]

  
	
  FUNDED THROUGH:  [***]

  
	
  CONTRACT EXPIRATION
  DATE:  [***]

  
	
   

  
	
  Except as provided
  herein, all terms and conditions of the document referenced in Item 9A or
  10A, as heretofore changed, remains unchanged and in full force and effect.

  
	
   

  
	
  15A.       NAME
  AND TITLE OF SIGNER (Type or print)

  	
  16A.  NAME AND
  TITLE OF CONTRACTING OFFICER (Type or print)

  
	
   

  	
  [***]

  [***]

  
	
   

  	
   

  
	
  15B. CONTRACTOR/OFFEROR

  	
  15C. DATE SIGNED

  	
  16B. UNITED STATES OF AMERICA

  	
  16C. DATE SIGNED

  
	
   

  	
   

  	
  BY

  [***]

  	
  [***]

  
	
  (Signature
  of person authorized to sign)

  	
  (Signature
  of Contracting Officer)

  
	
   

  
	
  NSN 7540-01-152-8070

  	
  OMB No. 0990-0115

  	
   

  	
  STANDARD FORM 30 (REV. 10-83)

  FAR (48 CFR) 53.243

  
									



 

















 


	
  AMENDMENT
  OF SOLICITATION/MODIFICATION OF CONTRACT

  	
  1.       CONTRACT ID CODE

  	
  PAGE OF PAGES

  
	
   

  	
   

  	
  1

  	
  5

  
	
   

  	
   

  	
   

  	
   

  
	
  2.        AMENDMENT/MODIFICATION NO

  	
  3.   EFFECTIVE DATE

  	
  4.        REQUISITION/PURC

  	
  5.        PROJECT NO. (If
  applicable)

  
	
  Mod #02

  	
  See Block 16 C

  	
  N/A

  	
  N/A

  
	
   

  	
   

  	
   

  	
   

  
	
  6.        ISSUED BY

  	
  CODE

  	
   

  	
  7.        ADMINISTERED BY (If other
  than Item 6)

  	
  CODE

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  National Institutes of
  Health

  Contract Management
  Program, NIAID

  6700-B Rockledge Drive

  Room 3214, MSC 7612

  Bethesda, MD  20892-7612

  	
   

  
										



 


	
  8.

  	
  NAME AND ADDRESS OF
  CONTRACTOR (No., street, county, State and ZIP Code)

  	
  x

  	
  9A.    AMENDMENT OF SOLICITATION NO.

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  Avecia Limited

  	
   

  	
  9B.       DATED (SEE ITEM
  11)

  
	
   

  	
  P.O. Box 42,
  Hexagon House

  	
   

  	
   

  
	
   

  	
  Blackley,
  Manchester, M9 8ZS, UK

  	
   

  	
   

  
	
   

  	
   

  	
  x

  	
  10A.   MODIFICATION OF CONTRACT/ORDER NO.

  
	
   

  	
   

  	
   

  	
  N01-AI-40034

  
	
   

  	
   

  	
   

  	
   

  
	
  CODE

  	
   

  	
  FACILITY CODE

  	
   

  	
  10B.    DATED (SEE ITEM 13)

  September 30, 2004

  
						



 


11.  THIS ITEM ONLY APPLIES TO AMENDMENTS OF
SOLICITATIONS


 


o The above numbered solicitation is
amended as set forth in Item 14.  The
hour and date specified for receipt of Offers o is
extended, o is not extended.


 


Offers must acknowledge
receipt of this amendment prior to the hour and date specified in the
solicitation or as amended, by one of the following methods:


 


(a) By completing
Items 8 and 15, and returning                  copies
of the amendment; (b) By acknowledging receipt of this amendment on each
copy of the offer submitted; or (c) By separate letter or telegram which
includes a reference to the solicitation and amendment numbers.  FAILURE OF YOUR ACKNOWLEDGEMENT TO BE
RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR
AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER.  If by virtue of this amendment, you desire to
change an offer already submitted, such change may be made by telegram or
letter, provided each telegram or letter makes reference to the solicitation
and this amendment, and is received prior to the opening hour and date
specified.


 


12.     ACCOUNTING AND APPROPRIATION DATA (If required)


 


13.     THIS ITEM APPLIES ONLY TO MODIFICATIONS OF
CONTRACT/ORDERS, IT MODIFIES THE CONTRACT/ORDER NO. AS
DESCRIBED IN ITEM 14.


 


	
  x

  	
  A.       THIS CHANGE ORDER IS ISSUED PURSUANT
  TO:  (Specify
  authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE
  CONTRACT ORDER NO. IN ITEM 10A.

  
	
   

  	
   

  
	
   

  	
  B.       THE ABOVE NUMBERED CONTRACT/ORDER IS
  MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as
  changes in paying office, appropriate date, etc.) SET FORTH IN
  ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).

  
	
   

  	
   

  
	
  x

  	
  C.       THIS SUPPLEMENTAL AGREEMENT IS ENTERED
  INTO PURSUANT TO AUTHORITY OF:

  
	
  FAR 1.602-1

  
	
   

  	
   

  
	
   

  	
  D.       OTHER (Specify
  type of modification and authority)

  
	
   

  
	
  E.        IMPORTANT:
   Contractor o is not, x is required to sign this document and
  return 3 copies to the issuing office.

  
	
   

  
	
  14.   DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract
  subject matter where feasible)

  
	
   

  
	
  PURPOSE:  To update Article B.2., to revise the
  milestone payment schedule in Article B.4. and
  to replace Limitation of Cost Clause with Limitation of Funds in Article I.2.

  
	
   

  
	
  TOTAL AMOUNT
  FUNDED:  [***] (unchanged)

  
	
  TOTAL ESTIMATED
  COST:  [***] (unchanged)

  
	
  FUNDED THROUGH:  [***] (unchanged)

  
	
  CONTRACT EXPIRATION
  DATE:  March 29, 2007 (unchanged)

  
	
   

  
	
  Except as provided
  herein, all terms and conditions of the document referenced in Item 9A or
  10A, as heretofore changed, remains unchanged and in full force and effect.

  
	
   

  
	
  15A. NAME AND TITLE OF
  SIGNER (Type or print)

  	
  16A. NAME AND TITLE OF
  CONTRACTING OFFICER (Type or print)

  
	
  [***]

  	
  [***]

  [***]

  
	
   

  	
   

  
	
  15B. CONTRACTOR/OFFEROR

  	
  15C. DATE SIGNED

  	
  16B. UNITED STATES OF AMERICA

  	
  16C. DATE SIGNED

  
	
  [***]

  	
  5thJan2005

  	
  BY

  	
  [***]

  	
  [***]

  
	
  (Signature
  of person authorized to sign)

  	
   

  	
  (Signature
  of Contracting Officer)

  	
   

  
	
   

  
	
  NSN 7540-01-152-8070

  	
  OMB No. 0990-0115

  	
   

  	
  STANDARD FORM 30 (REV. 10-83)

  FAR (48 CFR) 53.243

  
									



 

















 


	
  SPECIAL
  PROVISIONS

  	
  CONTRACT No. HHSN266200400034C

  Modification No. 2

  	
  Page 2 of 5 pages

  
	
   

  	
   

  	
   

  
	
  ARTICLE B.2. ESTIMATED
  COSTS AND FIXED FEE  - paragraphs e., f. and g. are added as follows:

  
	
   

  	
   

  	
   

  
	
  e.     Total funds currently available for
  payment and allocated to Part A of this contract are hereby decreased by
  [***] from [***]to [***], of which [***] represents
  a decrease to the estimated cost from [***] to [***]; and of which [***]
  represents a decrease to the fixed fee from [***] to [***].  For further provisions on funding, see the
  LIMITATION OF FUNDS Clause referenced in Part II, Article I.2., Authorized Substitution of Clauses.

  
	
   

  
	
  f.      It is estimated that the amount
  currently allotted will cover performance of the contract through [***].

  
	
   

  
	
  g.     Future increments to be allotted to the
  contract are estimated as follows:

  
	
   

  
	
   

  	
  PERIOD

  	
   

  	
  ESTIMATED COST

  	
   

  	
  FIXED FEE

  	
   

  	
  TOTAL AMOUNT

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  ARTICLE
  B.4.  ADVANCE UNDERSTANDINGS - paragraph i., is revised to read as
  follows:

  
	
   

  
	
  i.      Contract Milestones

  
	
   

  
	
  The
  Contractor shall complete all work in accordance with the Statement of Work
  and the contract milestones set forth below. 
  The distribution of the fixed fee shall be paid in milestone based
  installments and payment of this fee shall be determined by the Project
  Officer’s written certification that the milestone has been satisfactorily
  performed and that the technical requirements have been met regarding the
  completion of the following milestones: 
  If the Contractor meets the milestones earlier than the dates set
  forth below, then the fee will be paid at the earlier date after completion
  of the milestone.

  
	
   

  
	
   

  	
   

  	
  MILESTONE FOR AVECIA

  	
   

  	
  ESTIMATED

  COST

  	
   

  	
  FIXED FEE

  	
   

  	
  TOTAL

  CPFF

  
	
  1

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee
  shall be paid in five installments of the total fee for this milestone based
  on the completion of the following five items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  	
   

  	
  d)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  	
   

  	
  e)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Total
  Fee for Milestone

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  
																			



 

















 


	
  SPECIAL PROVISIONS

  	
  CONTRACT
  No. HHSN266200400034C

  Modification No. 2

  	
  Page 3 of 5 pages

  
	
   

  	
   

  	
   

  
	
  2

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee
  shall be paid in five installments of the total fee for this milestone based
  on the completion of the following five items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  	
   

  	
  d)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  	
   

  	
  e)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Total
  Fee for Milestone

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  3

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee
  shall be paid in three installments of the total fee for this milestone based
  on the completion of the following three items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
  [***]

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Total
  Fee for Milestone

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  4

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee
  shall be paid in two installments of the total fee for this milestone based
  on the completion of the following two items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  
											



 

















 


	
  SPECIAL PROVISIONS

  	
  CONTRACT
  No. HHSN266200400034C

  Modification No. 2

  	
  Page 4 of 5 pages

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Total
  Fee for Milestone

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  5

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee
  shall be paid in three installments of the total fee for this milestone based
  on the completion of the following three items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Total
  Fee for Milestone

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  6

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee
  shall be paid in four installments of the total fee for this milestone based
  on the completion of the following four items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  	
   

  	
  d)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Total
  Fee for Milestone

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  
										



 

















 


	
  SPECIAL PROVISIONS

  	
  CONTRACT
  No. HHSN266200400034C

  Modification No. 2

  	
  Page 5 of 5 pages

  
	
   

  	
   

  	
   

  
	
  7

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee
  shall be paid in three installments of the total fee for this milestone based
  on the completion of the following two items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Total Fee for Milestone

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  8

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee
  shall be paid in two installments of the total fee for this milestone based
  on the completion of the following three items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Total Fee for Milestone

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  
											



 






* Milestone 3 was subject to discussion regarding the progress of this
project prior to NIAID involvement.  At
the time of the RFP, Avecia described their current projects status and it was
agreed funds from this milestone should be channeled towards [***] if needed.


 


ARTICLE I.2  AUTHORIZED
SUBSTITUTION OF CLAUSES, is hereby modified to include the following:


 


ARTICLE I.1.  of this section is
modified as follows:


 


FAR
Clause 52.232-20, LIMITATION OF COST, is deleted in its entirety and FAR Clause
52.232-22, LIMITATION OF FUNDS (APRIL 1984) is substituted therefore.  Note:  When this contract is fully funded, FAR
Clause 52.232-22, LIMITATIONS OF FUNDS, will no longer apply and FAR Clause
52.232-20, LIMITATION OF COST will become applicable.


 


All other terms and
conditions of the contract remain unchanged.


 




















 


	
  AMENDMENT
  OF SOLICITATION/MODIFICATION OF CONTRACT

  	
  1.      CONTRACT ID CODE

  	
  PAGE OF PAGES

  
	
   

  	
   

  	
  1

  	
   3

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
  2.    AMENDMENT/MODIFICATION NO

  Mod #03

  	
  3. EFFECTIVE DATE

  See Block 16 C

  	
  4. REQUISITION/PURC

  N/A

  	
  5. PROJECT NO. (If applicable)

  N/A

  
	
   

  	
   

  	
   

  	
   

  
	
  6. ISSUED BY

  	
  CODE

  	
   

  	
  7. ADMINISTERED BY (If other than item 6)

  	
  CODE

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  National Institutes of
  Health

  Contract Management
  Program, NIAID

  6700-B Rockledge Drive

  Room 3214, MSC 7612

  Bethesda, MD 20892-7612

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
  8. NAME AND ADDRESS OF
  CONTRACTOR (No., street, county, State and ZIP Code)

  	
  x

  	
  9A. AMENDMENT OF
  SOLICITATION NO.

  
	
   

  	
   

  
	
   

  	
  Avecia Limited

  P.O. Box 42, Hexagon House

  Blackley, Manchester, M9 8ZS, UK

  	
   

  	
  9B. DATED (SEE ITEM 11)

  
	
   

  	
   

  	
   

  
	
   

  	
  x

  	
  10A. MODIFICATION OF
  CONTRACT/ORDER NO.

  
	
   

  	
   

  	
  N01-AI—40034

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
  10B. DATED (SEE ITEM 13)

  September 30, 2004

  
	
  CODE

  	
  FACILITY CODE

  
													



 


11.
THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS


 


o The above numbered solicitation is
amended as set forth in Item 14.  The
hour and date specified for receipt of Offers o is
extended.o  is not extended.




Offer must acknowledge
receipt of this amendment prior to the hour and date specified in the
solicitation or as amended, by one of the following methods


 


(a) By competing
Items 8 and 15, and returning                   
copies of the amendment; (b) By acknowledge receipt of this amendment on
each copy of the offer submitted; or (c) By separate letter or telegram
which includes a reference to the solicitation and amendment numbers.  FAILURE OF YOUR ACKNOWLEDGEMENT TO BE
RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR
AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER.  If by virtue of this amendment, you desire to
change an offer already submitted, such change may be made by telegram or
letter, provided each telegram or letter makes reference to the solicitations
and this amendment, and is received prior to the opening hour and date
specified.


 


12. ACCOUNTING AND APPROPRIATION DATA (If required)


 


13. THIS ITEM APPLIES ONLY TO
MODIFICATIONS OF CONTRACTS/ORDERS, IT MODIFIES THE
CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.


 


	
  x

  	
  A.    THIS CHANGE ORDER IS ISSUED PURSUANT
  TO:  (Specify
  authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE
  CONTRACT ORDER NO. IN ITEM 10A.

  
	
   

  
	
   

  
	
   

  	
  B.     THE ABOVE NUMBERED CONTRACT/ORDER IS
  MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as
  changes in paying office, appropriation date, etc.) SET FORTH IN
  ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).

  
	
   

  	
   

  
	
  x

  	
  C.     THIS SUPPLEMENTAL AGREEMENT IS ENTERED
  INTO PURSUANT TO AUTHORITY OF:

  FAR 1.602-1

  
	
   

  	
   

  
	
   

  	
  D.    OTHER (Specify type of
  modification and authority)

  
	
   

  	
   

  
	
  E.     IMPORTANT:  Contractor o is not, x is required to sign this document and
  return 3 copies to the issuing office.

  
	
   

  
	
  14. DESCRIPTION OF
  AMENDMENT/MODIFICATION (Organized by UCF section
  headings, including solicitation/contract subject matter where feasible)

  
	
   

  
	
  PURPOSE:  To revise the milestone 1 payment schedule,
  to add an Advance Understanding containing DMID’s approval of data sharing
  between Avecia and the UK Medicines Supply Agency in Article B.4. and to update Section H. articles.

  
	
   

  
	
  TOTAL AMOUNT
  FUNDED:  [***] (unchanged)

  
	
  TOTAL ESTIMATED
  COST:  [***] (unchanged)

  
	
  FUNDED THROUGH:  [***] (unchanged)

  
	
  CONTRACT EXPIRATION
  DATE:  [***] (unchanged)

  
	
   

  
	
  Except as provided
  herein, all terms and conditions of the document referenced in Item 9A or
  10A, as heretofore changed, remains unchanged and in full force and effect.

  
	
   

  
	
  15A. NAME AND TITLE OF
  SIGNER (Type or print)

  	
  16A. NAME AND TITLE OF
  CONTRACTING OFFICER (Type or print)

  
	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  
	
  15B. CONTRACTOR/OFFEROR

  	
  15C. DATE SIGNED

  	
  16B. UNITED STATES OF AMERICA

  	
  16C. DATE SIGNED

  
	
  [***]

  	
  23-06-05

  	
  BY

  	
  [***]

  	
  7/20/05

  
	
  (Signature
  of person authorized to sign)

  	
   

  	
  (Signature
  of Contracting Officer)

  	
   

  
	
   

  
	
  NSN 7540-01-152-8070

  	
  OMB No. 0990-0115

  	
   

  	
  STANDARD FORM 30 (REV. 10-83)

  FAR (48 CFR) 53.243

  
									



 

















 


	
  SPECIAL PROVISIONS

  	
  CONTRACT
  No. HHSN266200400034C

  Modification No. 3

  	
  Page 2 of 3 pages

  
	
   

  	
   

  	
   

  
	
  ARTICLE
  B.4.  ADVANCE UNDERSTANDINGS - paragraph i., item No. 1, is revised
  to read as shown below and paragraph p. is added as follows:

  
	
   

  	
   

  	
   

  
	
  i.      Contract Milestones

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
  The
  Contractor shall complete all work in accordance with the Statement of Work
  and the contract milestones set forth below. 
  The distribution of the fixed fee shall be paid in milestone based
  installments and payment of this fee shall be determined by the Project
  Officer’s written certification that the milestone has been satisfactorily
  performed and that the technical requirements have been met regarding the
  completion of the following milestones: 
  If the Contractor meets the milestones earlier than the dates set
  forth below, then the fee will be paid at the earlier date after completion
  of the milestone.

  
	
   

  
	
   

  	
   

  	
  MILESTONE FOR AVECIA

  	
   

  	
  ESTIMATED

  COST

  	
   

  	
  FIXED FEE

  	
   

  	
  TOTAL

  CPFF

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  1

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee
  shall be paid in five installments of the total fee for this milestone based
  on the completion of the following five items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  d)
  [***]

  	
   

  	
   

  	
   

  	
  d)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  e)
  [***]

  	
   

  	
   

  	
   

  	
  e)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  f)
  [***]

  	
   

  	
   

  	
   

  	
  f)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Total
  Fee for Milestone

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  
	
   

  
	
  p.             [***]

  
											



 

















 


	
  SPECIAL PROVISIONS

  	
  CONTRACT
  No. HHSN266200400034C

  Modification No. 3

  	
  Page 3 of 3 pages

  
	
   

  	
   

  	
   

  [***]

  	
   

  
				



 


All
other terms and conditions of the contract remain unchanged.


 
















 


	
  AMENDMENT
  OF SOLICITATION/MODIFICATION OF CONTRACT

  	
  1.  CONTRACT
  ID CODE

  N/A

  	
   

  	
  PAGE
  OF PAGES

  
	
   

  	
  1

  	
        3

  
	
   

  	
   

  	
   

  	
   

  
	
  2.    AMENDMENT/MODIFICATION
  NO

  	
  3.  EFFECTIVE DATE

  	
  4.  REQUISITION/PURCHASE
  REQ. NO.

  	
  5.  PROJECT
  NO. (If applicable)

  
	
  04

  	
  See Block 16 C, below

  	
  DMID 2 018

  	
  N/A

  
	
   

  	
   

  	
   

  	
   

  
	
  6.  ISSUED BY

  	
  CODE

  	
   

  	
  7.  ADMINISTERED
  BY (If other than Item 6)

  	
    CODE

  	
  N/A

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  National
  Institutes of Health

  	
   

  	
   

  	
   

  
	
  National
  Institute of Allergy and Infectious Diseases

  	
   MID2 - RCB

  	
   

  	
   

  
	
  DEA,
  Contract Management Branch

  	
   

  	
   

  	
   

  
	
  Room
  2230, MSC 7612

  	
   

  	
   

  	
   

  
	
  6700-B
  Rockledge Drive

  	
   

  	
   

  	
   

  
	
  Bethesda,
  MD  20892-7612

  	
   ADB
  Contract No. N01-AI-40034

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
  8.  NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP Code)

  	
  x

  	
  9A.  AMENDMENT
  OF SOLICITATION NO.

  
	
   

  	
   

  	
   

  
	
  Avecia Limited

  	
   

  	
  9B.  DATED
  (SEE ITEM 11)

  
	
  P.O. Box 42, Hexagon
  House

  	
   

  	
   

  
	
  Blackley, Manchester, M9
  8ZS, UK

  	
  x

  	
  10A.  MODIFICATION
  OF CONTRACT/ORDER NO.

  
	
   

  	
   

  	
  HHSN266200400034C

  
	
   

  	
   

  	
   

  
	
   

  	
  10B.  DATED (SEE ITEM 13)

  
	
  CODE

  	
  FACILITY CODE

  	
  September 30, 2004

  
	
   

  	
   

  	
   

  	
   

  
	
  11.  THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

  
	
   

  
	
  o The above numbered solicitation is
  amended as set forth in Item 14.  The
  hour and date specified for receipt of Offers o is extended, o is not extended.

   

  Offers must acknowledge
  receipt of this amendment prior to the hour and date specified in the
  solicitation or as amended, by one of the following methods:

   

  (a) By completing
  Items 8 and 15, and returning one (1) copy of the amendment; (b) By
  acknowledging receipt of this amendment on each copy of the offer submitted;
  or (c) By separate letter or telegram which includes a reference to the
  solicitation and amendment numbers. 
  FAILURE OF YOUR ACKNOWLEDGEMENT TO BE RECEIVED AT THE PLACE DESIGNATED
  FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED
  MAY RESULT IN REJECTION OF YOUR OFFER. 
  If by virtue of this amendment you desire to change an offer already
  submitted, such change may be made by telegram or letter, provided each
  telegram or letter makes reference to the solicitation and this amendment,
  and is received prior to the opening hour and date specified.

   

  
	
  12.  ACCOUNTING AND APPROPRIATION DATA (If required)

  EIN#:  1-900216013-A1                    SOCC  25.55 
  CAN 5-8460924                 [***]

   

  
	
  13.  THIS ITEM APPLIES ONLY TO MODIFICATIONS OF
  CONTRACT/ORDERS,

  IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

   

  
	
  x

  	
  A.

  	
  THIS
  CHANGE ORDER IS ISSUED PURSUANT TO:  (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE
  MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.

   

  
	
   

  	
  B.

  	
  THE
  ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE
  CHANGES (such as changes in paying office, appropriate
  date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR
  43.103(b).

   

  
	
   

   

  	
  C.

   

  	
  THIS
  SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:

   

  
	
  x

  	
  D.

  	
  OTHER
  (Specify type of modification and authority)

  
	
   

  	
       P.L.
  1.602-1, Limitation of Funds Clause; FAR 52.217-8; and P.L. 108-447

  
	
   

  	
   

  
	
  E.  IMPORTANT: 
  Contractor x is not, o is required to sign this document and return              copies
  to the issuing office.

   

  
	
  14.  DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract
  subject matter where feasible)

  
	
  PURPOSE: 
  To fund the final increment of funds for the base portion of the
  contract and to exercise and incrementally fund Option Period - Part B.

   

  
														



	
   

  	
   

  	
  Total
  Funds Currently Allotted

  	
   

  	
  Total
  Estimated Cost

  	
   

  
	
   

  	
   

  	
  Cost

  	
   

  	
  Fee

  	
   

  	
  Total

  	
   

  	
  Cost

  	
   

  	
  Fee

  	
   

  	
  Total

  	
   

  
	
  Prior to this Mod

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
  This Mod #

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
  Revised Total

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  



 


	
  FUNDED THROUGH
  DATE:  [***]   COMPLETION DATE:  [***]

  
	
   

  
	
  Except as provided
  herein, all terms and conditions of the document referenced in Item 9A or
  10A, as heretofore changed, remains unchanged and in full force and effect.

   

  
	
  15A.  NAME AND TITLE OF SIGNER (Type or print)

  	
  16A.  NAME AND TITLE OF CONTRACTING OFFICER (Type or print)

  
	
   

  	
  [***]

  
	
   

  	
  [***]

  
	
   

  	
   

  
	
  15B.  CONTRACTOR/OFFEROR

  	
  15C.  DATE SIGNED

  	
  16B.  UNITED STATES OF AMERICA

  	
  16C.  DATE SIGNED

  
	
   

  	
   

  	
   

  	
  [***]

  
	
   

  	
   

  	
  BY

  	
   

  	
  [***]

  	
   

  
	
  (Signature of person authorized to sign)

  	
   

  	
   

  	
  (Signature
  of Contracting Officer)

  	
   

  
	
   

  	
   

  	
   

  
	
  NSN 7540-01-152-8070

  PREVIOUS EDITION
  UNUSABLE

  	
  30-105

  Computer
  Generated

  	
   

  	
  STANDARD FORM 30 (REV.
  10-83)

  Prescribed by GSA

  FAR (48 CFR) 53.243

  
								



 

















 


	
  Contract No. HHSN266200400034C

  Modification No. 04

  	
   

  	
  SPECIAL PROVISIONS

  	
   

  	
  Page 2 of 3

  



 


ARTICLE B.2. ESTIMATED COST AND FIXED FEE - paragraphs
b. and c., are hereby modified to read as follows:


 


	
  a.

  	
  The
  estimated cost of this contract is increased by [***] from [***] to [***].

  
	
   

  	
   

  
	
  b.

  	
  The fixed fee of this
  contract is increased by [***] from [***]. 
  The fixed fee shall be paid in installments based on the negotiated
  milestones set forth in ARTICLE B.4., paragraph i, and subject to the
  withholding provisions of the clauses ALLOWABLE COST AND PAYMENT and FIXED
  FEE referenced in the General Clause Listing in Part II, ARTICLE 1.1.,
  of this contract.  Payment shall not be
  made in less than monthly installments.

  
	
   

  	
   

  
	
  c.

  	
  The Government’s
  obligation, represented by the sum of the estimated cost plus the fixed fee
  of this contract is increased by [***] from [***] to [***]

  
	
   

  	
   

  
	
  e.

  	
  Total funds currently
  available for payment and allotted to this contract are hereby increased by
  [***] from [***] to [***]; of which [***] represents an increase to the
  estimated cost from [***] to [***]; and of which [***] represents an increase
  to the fixed fee from [***] to [***]. 
  For further provisions on funding, see the LIMITATION OF FUNDS Clause
  referenced in Part II, ARTICLE I.2., Authorized Substitutions of Clauses.

  
	
   

  	
   

  
	
  f.

  	
  It is estimated that the
  amount currently allotted will cover performance of the contract through
  [***].

  
	
   

  	
   

  
	
  g.

  	
  The total of future
  increments to be allotted to the contract are estimated as follows:

  



 


	
  PERIOD

  	
   

  	
  ESTIMATED COST

  	
   

  	
  FIXED FEE

  	
   

  	
  TOTAL AMOUNT

  	
   

  
	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  



 


ARTICLE F.1.  PERIOD OF PERFORMANCE , paragraph a. is hereby modified to read as
follows:


 


	
  a.

  	
  The period of performance
  of this contract shall be from [***] through September [***].

  



 


ARTICLE H.5.  CONTINUED BAN ON
FUNDING OF HUMAN EMBRYO RESEARCH, paragraph b. is hereby modified to add the following:


 


	
  b.

  	
  Public Law and Section No.

  	
   

  	
  Fiscal
  Year

  	
   

  	
  Period
  Covered

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  P.L. 108-447, Title V -
  General Provisions, Section 509

  	
   

  	
  2005

  	
   

  	
  10/01/04 - 09/30/05

  	
   

  



 


ARTICLE H.6.  NEEDLE EXCHANGE, paragraph b. is hereby modified to add the
following:


 


	
  b.

  	
  Public Law and Section No.

  	
   

  	
  Fiscal
  Year

  	
   

  	
  Period
  Covered

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  P.L.
  108-447, Title V - General Provisions, Section 505

  	
   

  	
  2005

  	
   

  	
  10/01/04 - 09/30/05

  	
   

  



 


ARTICLE H.11.  SALARY RATE
LIMITATION LEGISLATION PROVISIONS, paragraphs b. and c. are hereby modified to add the following:


 


	
  b.

  	
  Public Law No.

  	
   

  	
  Fiscal
  Year

  	
   

  	
  Dollar
  Amount of

  Salary Limitation*

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  P.L.
  108-447, Title II - General Provisions, Section 204

  	
   

  	
  2005

  	
   

  	
  Executive Level I

  	
   

  



 


	
  c.

  	
  Direct
  salaries are limited to the Executive Level I rate which was in effect on the
  date(s) the expense was incurred.

  



 


HHS-556


 

















 






	
   

  	
  * For the period
  10/1/04-12/31/04, the Executive Level I rate is $175,700.  Effective 1/1/05, the Executive Level I
  rate increased to $180,100 and will remain at that rate until it is
  revised.  See the web site listed below
  for Executive Schedule rates of pay.

  
	
   

  	
   

  
	
   

  	
  LINK to EXECUTIVE LEVEL
  SALARIES:
  http://www.opm.gov/oca/05tables/html/ex.asp 
  (For previous years, go to:
  http://www.opm.gov/oca/05tables/index.asp 
  and click on the year to locate the Executive Level salary rates.)

  
	
   

  	
   

  
	
   

  	
  NOTE:  All prior Public Laws and related Executive
  Levels incorporated in the Basic Award and all previous Modifications shall
  remain in effect for the applicable fiscal year and related funds.

  



 


ARTICLE H.13.  PRESS RELEASES, paragraph b., is hereby modified to add the
following:


 


	
  b.

  	
  Public Law and Section No.

  	
   

  	
  Fiscal Year

  	
   

  	
  Period Covered

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  P.L.
  108-447, Title V - General Provisions, Section 506

  	
   

  	
  2005

  	
   

  	
  10/01/04 - 9/30/05

  	
   

  



 


ARTICLE H.15.  ANTI-LOBBYING, paragraph c., is hereby modified to add the
following:


 


	
  b.

  	
  Public Law and Section No.

  	
   

  	
  Fiscal
  Year

  	
   

  	
  Period
  Covered

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  for a., above: P.L.
  108-447, Title V - General Provisions, Section 503a

  	
   

  	
  2005

  	
   

  	
  10/01/04 - 9/30/05

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  for b., above: P.L.
  108-447, Title V - General Provisions, Section 503b

  	
   

  	
  2005

  	
   

  	
  10/01/04 - 9/30/05

  	
   

  



 


HHS-556


 
















 


	
  AMENDMENT OF
  SOLICITATION/MODIFICATION OF CONTRACT

  	
  1.        CONTRACT ID CODE

  	
  PAGE OF PAGES

  	 

	
  N/A

  	
  1

  	
  16

  	 

	
   

  	
   

  	
   

  	
   

  	 

	
  2.        AMENDMENT/MODIFICATION NO

  	
  3.        EFFECTIVE DATE

  	
  4.        REQUISITION/PURCHASE REQ NO.

  	
  5.        PROJECT NO. (If
  applicable)

  	 

	
  05

  	
  See Block 16 C, below

  	
  2006-0361

  	
  N/A

  	 

	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	 

	
  6.

  	
  ISSUED BY

  	
  CODE

  	
   

  	
  7.        ADMINISTERED BY (If other
  than Item 6)

  	
  CODE

  	
  N/A

  	 

	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	 

	
   

  	
  National Institutes of
  Health

  National Institute of
  Allergy and Infectious Diseases

  DEA, Office of
  Acquisitions

  Room 3214, MSC 7612

  6700-B Rockledge Drive

  Bethesda, MD  20892-7612

  	
   

  MID RCB-B

   

   

   

  ADB Contract
  No. N01-AlI40034

  	
	
   

  	
   

  	
   

  	 

	
  8.        NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP Code)

  	
  x

  	
  9A.

  	
  AMENDMENT OF
  SOLICITATION NO.

  	 

	
   

  	
   

  	
   

  	 

	
  Avecia Limited

  P.O. Box 42, Hexagon House

  Blackley, Manchester, M9 8ZS, UK

  	
   

  	
   

  	 

	
  9B.

  	
  DATED (SEE ITEM 11)

  	 

	
   

  	
	
  x

  	
  10A.

  	
  MODIFICATION OF
  CONTRACT/ORDER NO.

  	 

	
  HHSN266200400034C

  	 

	
   

  	 

	
  10B.

  	
  DATED
  (SEE ITEM 13)

  September 30,
  2004

  	
	
  CODE

  	
  FACILITY CODE

  	 

	
   

  	
   

  	
   

  	
   

  	 

	
  11.  THIS ITEM ONLY APPLIES TO AMENDMENTS OF
  SOLICITATIONS

  	 

	
   

  	 

	
  o The above numbered solicitation is amended as set
  forth in Item 14.  The hour and date
  specified for receipt of Offers o is extended, o is not extended.

   

  Offers must acknowledge
  receipt of this amendment prior to the hour and date specified in the
  solicitation or as amended, by one of the following methods:

   

  (a) By completing
  Items 8 and 15, and returning one (1) copy of the amendment; (b) By
  acknowledging receipt of this amendment on each copy of the offer submitted;
  or (c) By separate letter or telegram which includes a reference to the
  solicitation and amendment numbers. 
  FAILURE OF YOUR ACKNOWLEDGEMENT TO BE RECEIVED AT THE PLACE DESIGNATED
  FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT
  IN REJECTION OF YOUR OFFER.  If by
  virtue of this amendment, you desire to change an offer already submitted,
  such change may be made by telegram or letter, provided each telegram or
  letter makes reference to the solicitation and this amendment, and is
  received prior to the opening hour and date specified.

  	 

	
   

  	 

	
  12.     ACCOUNTING AND APPROPRIATION DATA (If required)

  	 

	
  EIN#:  1-900216013-A1

  	
     SOCC  25.55 
  CAN 5-8467101 

  	
  [***]

  	 

	
   

  	
   

  	
   

  	 

	
  13.   THIS ITEM
  APPLIES ONLY TO MODIFICATIONS OF CONTRACT/ORDERS,

  IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

  	 

	
   

  	 

	
  x

  	
  A.

  	
  THIS CHANGE ORDER IS ISSUED PURSUANT TO:  (Specify authority)
  THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER NO. IN ITEM
  10A.

  	 

	
   

  	
   

  	 

	
   

  	
  B.

  	
  THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO
  REFLECT THE ADMINISTRATIVE CHANGES (such as changes in
  paying office, appropriate date, etc.) SET FORTH IN ITEM 14,
  PURSUANT TO THE AUTHORITY OF FAR 43.103(b).

  	 

	
   

  	
   

  	 

	
   

  	
  C.

  	
  THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT
  TO AUTHORITY OF:

  	 

	
   

  	 

	
  x

  	
  D.

  	
  OTHER (Specify type of
  modification and authority)

  	 

	
  FAR 1.602-1

  	 

	
   

  	
   

  	 

	
  E.

  	
  IMPORTANT:  Contractor o is not, x is required to sign this document and
  return 2 copies to the issuing office.

  	 

	
   

  	
   

  	 

	
  14.

  	
  DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract
  subject matter where feasible)

  	 

	
   

  	
   

  	 

	
  PURPOSE:  To add an
  increment of funds, thus fully funding the contract; to clarify the
  Part B Option Statement of Work, required Deliverables, and revise the
  related Milestone Estimated Cost and Fixed Fee distributions; to add the
  Alternate Project Officer; to change the Principal Investigator; and make
  other administrative changes.. 

  	 

																					 




 


	
   

  	
   

  	
  Total Funds Currently Allotted

  	
   

  	
  Total Estimated Cost

  	
   

  
	
   

  	
   

  	
  Cost

  	
   

  	
  Fee

  	
   

  	
  Total

  	
   

  	
  Cost

  	
   

  	
  Fee

  	
   

  	
  Total

  	
   

  
	
  Prior to this Mod

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
  This Mod #

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
  Revised Total

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  



 


	
  FUNDED THROUGH
  DATE:  [***]   COMPLETION DATE:  [***]

  
	
   

  
	
  Except as provided
  herein, all terms and conditions of the document referenced in Item 9A or
  10A, as heretofore changed, remains unchanged and in full force and effect.

  
	
   

  
	
  15A.

  	
  NAME AND TITLE OF SIGNER
  (Type or print)

  	
  16A.

  	
  NAME AND TITLE OF
  CONTRACTING OFFICER (Type or print)

  
	
   

  	
  [***]

  	
   

  	
  [***]

  [***]

  
	
   

  	
   

  
	
  15B. CONTRACTOR/OFFEROR

  	
  15C. DATE SIGNED

  	
  16B. UNITED STATES OF AMERICA

  	
  16C. DATE SIGNED

  
	
   

  	
          21SEP06

  	
   

  	
  [***]

  
	
  [***]

  	
   

  	
  BY

  	
  [***]

  	
   

  
	
  (Signature
  of person authorized to sign)

  	
  (Signature
  of Contracting Officer)

  
	
   

  	
   

  	
   

  	
   

  
	
  NSN 7540-01-152-8070

  PREVIOUS EDITION
  UNUSABLE

  	
  30-105

  Computer Generated

  	
   

  	
  STANDARD FORM 30
  (REV. 10-83)

  Prescribed by GSA

  FAR (48 CFR) 53.243

  
									



 

















 




	
  Contract
  No. HHSN266200400034C

  Modification No. 05

  	
   

  	
  SPECIAL PROVISIONS

  	
   

  	
  Page 2 of 16

  






 


ARTICLE B.2. ESTIMATED
COSTS AND FIXED FEE  - paragraphs e. and f., are hereby modified to read as
follows and g. is deleted in its entirety:


 


e.               Total funds currently available for payment
and allocated to Part A of this contract are hereby increased by [***]
from [***]to [***], of which [***] represents an increase to the estimated cost
from [***] to [***]; and of which [***] represents an increase to the fixed fee
from [***] to [***]. For further provisions on funding, see the LIMITATION OF
COST Clause referenced in Part II, ARTICLE I.1., General Clauses for a
Cost Reimbursement Research and Development Contract.


 


f.                 By virtue of the fact that this contract is
fully funded, it is estimated that the amount currently allotted will cover
performance through the completion date of the contract.


 


ARTICLE
B.4.  ADVANCE UNDERSTANDINGS - paragraph i., is hereby modified as follows
to update the Milestone Schedule:


 


	
   

  	
   

  	
  MILESTONES FOR AVECIA

  	
   

  	
  ESTIMATED

  COST

  	
   

  	
  FIXED FEE

  	
   

  	
  TOTAL

  CPFF

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  1

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in six installments of the total
  fee for this milestone based on the completion of the following six items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
  d)
  [***]

  	
   

  	
   

  	
   

  	
  d)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
  e)
  [***]

  	
   

  	
   

  	
   

  	
  e)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
  f)
  [***]

  	
   

  	
   

  	
   

  	
  f)
  [***]

  	
   

  	
   

  



 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 05

  	
   

  	
  SPECIAL PROVISIONS

  	
   

  	
  Page 3 of 16

  



 


	
  2

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in five installments of the total
  fee for this milestone based on the completion of the following five items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  d)
  [***]

  	
   

  	
   

  	
   

  	
  d)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  e)
  [***]

  	
   

  	
   

  	
   

  	
  e)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  3

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in three installments of the total
  fee for this milestone based on the completion of the following three items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  [***]

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  



 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 05

  	
   

  	
  SPECIAL PROVISIONS

  	
   

  	
  Page 4 of 16

  



 


	
  4

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in three installments of the
  total fee for this milestone based on the completion of the following two
  items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  5

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in three installments of the
  total fee for this milestone based on the completion of the following three
  items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  6

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in four installments of the total
  fee for this milestone based on the completion of the following four items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  d)
  [***]

  	
   

  	
   

  	
   

  	
  d)
  [***]

  	
   

  	
   

  



 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 05

  	
   

  	
  SPECIAL PROVISIONS

  	
   

  	
  Page 5 of 16

  



 


	
  7

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in two installments of the total
  fee for this milestone based on the completion of the following two items.

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  8

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in three installments of the
  total fee for this milestone based on the completion of the following three
  items.

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  9

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in six installments of the total
  fee for this milestone based on the completion of the following six items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  d)
  [***]

  	
   

  	
   

  	
   

  	
  d)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  e)
  [***]

  	
   

  	
   

  	
   

  	
  e)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  f)
  [***]

  	
   

  	
   

  	
   

  	
  f)
  [***]

  	
   

  	
   

  



 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 05

  	
   

  	
  SPECIAL PROVISIONS

  	
   

  	
  Page 6 of 16

  



 


	
  10

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in four installments of the total
  fee for this milestone based on the completion of the following four items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  d)
  [***]

  	
   

  	
   

  	
   

  	
  d)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  11

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in four installments of the total
  fee for this milestone based on the completion of the following fouritems:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  d)
  [***]

  	
   

  	
   

  	
   

  	
  d)
  [***]

  	
   

  	
   

  



 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 05

  	
   

  	
  SPECIAL PROVISIONS

  	
   

  	
  Page 7 of 16

  



 


	
  12

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in nine installments of the total
  fee for this milestone based on the completion of the following nine items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  d)
  [***]

  	
   

  	
   

  	
   

  	
  d)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  e)
  [***]

  	
   

  	
   

  	
   

  	
  e)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  f)
  [***]

  	
   

  	
   

  	
   

  	
  f)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  g)
  [***]

  	
   

  	
   

  	
   

  	
  g)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  h)
  [***]

  	
   

  	
   

  	
   

  	
  h)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  i)
  [***]

  	
   

  	
   

  	
   

  	
  i)
  [***]

  	
   

  	
   

  



 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 05

  	
   

  	
  SPECIAL PROVISIONS

  	
   

  	
  Page 8 of 16

  



 


	
  13

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in three installments of the
  total fee for this milestone based on the completion of the following three
  items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  d)
  [***]

  	
   

  	
   

  	
   

  	
  d)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  14

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in three installments of the
  total fee for this milestone based on the completion of the following three
  items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  



 


HHS-556


 
















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 05

  	
  SPECIAL PROVISIONS

  	
  Page 9 of 16

  



 


	
  15

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in two installments of the total
  fee for this milestone based on the completion of the following two items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  16

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in four installments of the total
  fee for this milestone based on the completion of the following four items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  	
   

  	
  d)
  [***]

  	
   

  	
   

  



 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C 

  Modification No. 05

  	
  SPECIAL PROVISIONS

  	
  Page 10 of 16

  



 


	
  17

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in five
  installments of the total fee for this milestone based on the completion of
  the following five items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  	
   

  	
  d)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  	
   

  	
  e)
  [***]

  	
   

  	
   

  



 


ARTICLE C.1 STATEMENT OF WORK, is hereby modified to read as follows:


 


Independently
and not as an agent of the Government, the Contractor shall furnish all the
necessary services qualified personnel, material, equipment, and facilities,
not otherwise provided by the Government as needed to perform the Statement of
Work, SECTION J, ATTACHMENT 1, dated September 30, 2004, and as
clarified by Modification No. 5 of the contract, attached hereto and made
a part of this contract.


 


ARTICLE C.3 OTHER DELIVERABLES, is hereby added as follows:


 


In addition to the
deliverables required by ARTICLE C.2.  and ARTICLE F.2, or
otherwise described by the Statement of Work of this contract, the following
are to be delivered per the direction of the Project Officer prior to the
completion date of the contract:


 


1.     Materials,
supplied, and equipment purchased for this contract but not expended in the
execution of the Statement of Work.


 


2.     Drug
Substance not allocated for retains (in amounts needed to maintain GMP
compliance), reference standard, clinical trials, or stability studies as
defined in the SOW.


 


3      Drug
Product not allocated for retains (in amounts needed to maintain GMP
compliance), reference standard, clinical trials, or stability studies as
defined in the SOW.


 


4      Consented
clinical specimens collected during the course of any clinical trial and not
used in the protocol-specific studies or held as retains (in amounts described
in the clinical trial documentation).


 


5.     Copies
of regulatory submissions.


 


6.     Analytical
methods and models developed as part of the execution of this SOW.


 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 05

  	
  SPECIAL PROVISIONS

  	
  Page 11 of 16

  



 


	
  7.     Quality audit reports subject to Avecia’s confidentiality
  obligations to its contractors.

  



 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 05

  	
  SPECIAL PROVISIONS

  	
  Page 12 of 16

  



 


ARTICLE F.2.  DELIVERIES  paragraph a., is
hereby modified to include the following table of deliverables in addition to
those deliveries currently required by the contract:


 


	
  Item

  	
   

  	
  Type of Deliverable

  	
   

  	
  SOW Reference

  	
   

  	
  Recipient

  	
   

  	
  Delivery Schedule

  	
   

  
	
  1.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
  2.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
  3.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
  4.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
  6.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
  7.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
  8.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
  9.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
  10.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
  11.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
  12.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
  13.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
  14.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
  15.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  



 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 05

  	
  SPECIAL PROVISIONS

  	
  Page 13 of 16

  



 


	
  Item

  	
   

  	
  Type of Deliverable

  	
   

  	
  SOW Reference

  	
   

  	
  Recipient

  	
   

  	
  Delivery Schedule

  	
   

  
	
  16.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
  17.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
  18.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
  19.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  



 


ARTICLE G.1.  PROJECT OFFICER,
is hereby modified to
include the following:


 


The following will represent the Government as the Alternate Project
Officer for the purposes of this contract:


 


[***]


[***]


[***]


[***]


Room 5006, MSC 6604


6610 Rockledge Drive


Bethesda, MD 20892-6604


 


ARTICLE G.2.  KEY PERSONNEL, is hereby modified to delete Mark Carver as
the Principal Investigator and to insert Matthew Duchars as the Principal
Investigator.


 


ARTICLE H.5.  CONTINUED BAN ON FUNDING OF HUMAN
EMBRYO RESEARCH, paragraph b. is hereby modified to add the
following:


 


	
  b.

  	
  Public Law and Section No.

  	
   

  	
  Fiscal
  Year

  	
   

  	
  Period
  Covered

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  P.L. 109-149,
  Title V – General Provisions, Section 509

  	
   

  	
  2006

  	
   

  	
  10/01/05 –
  9/30/06

  	
   

  



 


ARTICLE H.6.  NEEDLE EXCHANGE, paragraph b. is hereby modified to add the
following:


 


	
  b.

  	
  Public Law and Section No.

  	
   

  	
  Fiscal
  Year

  	
   

  	
  Period
  Covered

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  P.L. 109-149,
  Title V – General Provisions, Section 505

  	
   

  	
  2006

  	
   

  	
  10/01/05 –
  9/30/06

  	
   

  



 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 05

  	
  SPECIAL PROVISIONS

  	
  Page 14 of 16

  



 


ARTICLE H.11 SALARY RATE LIMITATION LEGISLATION PROVISIONS, paragraphs b. and c. are hereby modified to
add the following:


 


	
  b.

  	
  Public Law No.

  	
   

  	
  Fiscal
  Year

  	
   

  	
  Dollar Amount of Salary Limitation*

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  P.L. 109149

  	
   

  	
  2006

  	
   

  	
  Executive Level I

  	
   

  



 


c.               Payment
of direct salaries is limited to the Executive Level I* rate which was in
effect on the date(s) the expense was incurred.


 






*For the
period 10/1/05 – 12/31/05, the Executive Level I rate is $180,100.  Effective January 1, 2006, the Executive
Level I rate increased to $183,500 and will remain at that rate until it is
revised.  See the web site listed below
for the Executive Schedule rates of pay:


 


FOR
FY-06 EXECUTIVE LEVEL SALARIES EFFECTIVE JANUARY 1, 2006:


 


http://www.opm.gov/oca/06tables/html/ex.asp


(Note:  This site shows the FY-06 rates.  For previous years, click on “salaries and
wages” and then scroll down to the bottom of the page and click on the
year to locate the desired Executive Level salary rates.)


 


NOTE:  All prior Public Laws and related Executive
Levels incorporated in the Basic Award and all previous Modifications shall
remain in effect for the applicable fiscal year and related funds.


 


ARTICLE H.13. 
PRESS RELEASES.  paragraph b., is hereby
modified to add the following:


 


	
  b.

  	
  Public Law and Section No.

  	
   

  	
  Fiscal
  Year

  	
   

  	
  Period
  Covered

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  P.L. 109-149, Title V –
  General Provisions, Section 506

  	
   

  	
  2006

  	
   

  	
  10/01/05 –
  9/30/06

  	
   

  



 


ARTICLE H.15.   ANTI-LOBBYING.  paragraph c., is
hereby modified to add the following:


 


	
  b.

  	
  Public Law and Section No.

  	
   

  	
  Fiscal
  Year

  	
   

  	
  Period
  Covered

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  for a., above:  P.L. 109-149, Title V – General Provisions,
  Section 503a

  	
   

  	
  2006

  	
   

  	
  10/1/05 – 9/30/06

  	
   

  
	
   

  	
  for b., above:  P.L. 109-149, Title V – General Provisions,
  Section 503a

  	
   

  	
  2006

  	
   

  	
  10/1/05 – 9/30/06

  	
   

  



 


 


ARTICLE I.2  AUTHORIZED
SUBSTITUTION OF CLAUSES, is hereby modified to delete FAR Clause 52.232-22, LIMITATION OF FUNDS
(April 1984), reinstating the applicability of FAR Clause 52.232-20,
LIMITATION OF COST (April 1984) of ARTICLE I.1.


 


SECTION J — LIST OF ATTACHMENTS, item no. 1., is
hereby modified to read as follows:


 


1.               Statement
of Work, [***] (and as clarified by Modification No. 5), 5 pages.


 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 05

  	
  SPECIAL PROVISIONS

  	
  Page 15 of 16

  



 


ATTACHMENT 1 — STATEMENT OF WORK, is hereby modified to include the following
under the Part B Option section for clarification purposes:


 


[***]


[***]


[***]


[***]


 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 05

  	
  SPECIAL PROVISIONS

  	
  Page 16 of 16

  



 


[***]


[***]


[***]


[***]


 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 05

  	
  SPECIAL PROVISIONS

  	
  Page 17 of 16

  



 


[***]


 


HHS-556


 
















 


	
  AMENDMENT OF SOLICITATION/MODIFICATION OF
  CONTRACT

  	
  1.

  	
  CONTRACT
  ID CODE

  	
  PAGE OF PAGES

  
	
   

  	
  N/A

  	
  1

  	
  2

  
	
   

  	
   

  	
   

  	
   

  
	
  2.        AMENDMENT/MODIFICATION NO

  	
  3.        EFFECTIVE DATE

  	
  4.        REQUISITION/PURCHASE REQ NO.

  	
  5.        PROJECT NO. (If
  applicable)

  
	
  06

  	
    See
  Block 16 C, below

  	
   

  	
  N/A

  
	
   

  	
   

  	
   

  	
   

  
	
  6.        ISSUED BY

  	
  CODE

  	
   

  	
  7.        ADMINISTERED BY (If other
  than Item 6)

  	
  CODE

  	
  N/A

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  National Institutes of
  Health, HHS

  National Institute of Allergy and Infectious Diseases

  DEA, Office of Acquisitions

  6700-B Rockledge Drive, Room 3214, MSC 7612

  Bethesda, MD  20892-7612

  	
  

  MID RCB-B



   

   

   

  
	
  8.        NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP Code)

  	
  x

  	
  9A.  AMENDMENT OF SOLICITATION NO.

  
	
   

  
	
  Avecia Limited

  	
   

  	
  9B.    DATED (SEE ITEM
  11)

  
	
  P.O. Box 42,
  Hexagon House

  	
   

  	
   

  
	
  Blackley, Manchester, M9
  8ZS, UK

  	
  x

  	
  10A. MODIFICATION OF CONTRACT/ORDER NO.

  
	
   

  	
  HHSN266200400034C

  
	
   

  	
   

  
	
  CODE

  	
  FACILITY CODE

  	
  10B. DATED (SEE ITEM
  13)

  September 30, 2004

  
											



 


11.  THIS ITEM ONLY APPLIES TO AMENDMENTS OF
SOLICITATIONS


 


o The above numbered solicitation is amended as set
forth in Item 14.  The hour and date
specified for receipt of Offers o is extended, o is
not extended.




Offers
must acknowledge receipt of this amendment prior to the hour and date specified
in the solicitation or as amended, by one of the following methods:


 


(a) By
completing Items 8 and 15, and returning one (1) copy of the amendment;
(b) By acknowledging receipt of this amendment on each copy of the offer
submitted; or (c) By separate letter or telegram which includes a
reference to the solicitation and amendment numbers.  FAILURE OF YOUR ACKNOWLEDGEMENT TO BE
RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR
AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER.  If by virtue of this amendment, you desire to
change an offer already submitted, such change may be made by telegram or
letter, provided each telegram or letter makes reference to the solicitation
and this amendment, and is received prior to the opening hour and date
specified.


 


12.     ACCOUNTING AND APPROPRIATION DATA (If required)


 


	
  EIN#:  1-900216013-A1

  	
  SOCC  25.55

  	
   

  



 


13.                 THIS ITEM APPLIES ONLY TO MODIFICATIONS OF
CONTRACT/ORDERS,

IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.


 


	
  x

  	
  A.

  	
  THIS
  CHANGE ORDER IS ISSUED PURSUANT TO:  (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE
  IN THE CONTRACT ORDER NO. IN ITEM 10A.

  
	
   

  	
   

  	
   

  
	
   

  	
  B.

  	
  THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO
  REFLECT THE ADMINISTRATIVE CHANGES (such as changes in
  paying office, appropriate date, etc.) SET FORTH IN ITEM 14,
  PURSUANT TO THE AUTHORITY OF FAR 43.103(b).

  
	
   

  	
   

  	
   

  
	
   

  	
  C.

  	
  THIS
  SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:

  
	
   

  	
   

  	
   

  
	
  x  

  	
  D.

  	
  OTHER
  (Specify type of modification and authority)

  
	
  FAR
  1.602-1

  	
   

  
	
   

  
	
  E.          IMPORTANT:  Contractor x is not, o is required to sign this document and
  return              
  copies to the issuing office.

  
	
   

  
	
  DESCRIPTION OF
  AMENDMENT/MODIFICATION (Organized by UCF section
  headings, including solicitation/contract subject matter where feasible)

  
	
   

  
	
  PURPOSE:  Modify Invoice Payment Procedures under ARTICLE G.3.

  
	
   

  
	
  FUNDED THROUGH DATE:

  	
  [***](Unchanged)

  	
   

  	
  COMPLETION DATE:

  	
  [***] (Unchanged)

  	
   

  	
   

  
	
   

  
	
  Except as provided
  herein, all terms and conditions of the document referenced in Item 9A or
  10A, as heretofore changed, remains unchanged and in full force and effect.

  
	
   

  
	
  Except as provided
  herein, all terms and conditions of the document referenced in Item 9A or
  10A, as heretofore changed, remains unchanged and in full force and effect.

  
	
   

  
	
  15A. NAME AND TITLE OF
  SIGNER (Type or print)

  	
  16A. NAME AND TITLE OF CONTRACTING OFFICER (Type or print)

  
	
  [***]

  	
  [***]

  [***]

  
	
   

  	
   

  
	
  15B. CONTRACTOR/OFFEROR

  	
  15C. DATE SIGNED

  	
  16B. UNITED STATES OF AMERICA

  	
  16C. DATE SIGNED

  
	
   

  	
  14JUN07

  	
   

  	
  [***]

  
	
  [***]

  	
   

  	
  BY

  	
  [***]

  	
   

  
	
  (Signature of person
  authorized to sign)

  	
   

  	
   

  	
  (Signature of Contracting
  Officer)

  	
   

  
	
   

  	
   

  	
   

  
	
  NSN 7540-01-152-8070

  PREVIOUS EDITION UNUSABLE

  	
  30-105

  Computer Generated

  	
  STANDARD FORM 30
  (REV. 10-83)

  Prescribed by GSA

  FAR (48 CFR) 53.243

  
														



 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 6

  	
   

  	
  SPECIAL PROVISIONS

  	
   

  	
  Page 2 of 2

  



 


ARTICLE G.3.      INVOICE
SUBMISSION/CONTRACT FINANCING REQUEST AND CONTRACT FINANCIAL REPORT — is hereby
modified to read as follows:


 


a.                                       Invoice/Financing Request Instructions and
Contract Financial Reporting for NIH Cost-Reimbursement Type Contracts
NIH(RC)-4 are attached and made part of this contract.  The Contractor shall follow the attached
instructions and submission procedures specified below to meet the requirements
of a “proper invoice” pursuant to FAR Subpart 32.9, Prompt Payment.


 


(1)                                  Payment requests shall be submitted as
follows:


 


One original to the following designated
billing office:


 


National
Institutes of Health

Office of Financial Management

Commercial Accounts

2115 East Jefferson Street, Room 4B-432, MSC 8500

Bethesda, MD  20892-8500


 


(2)                                  In addition to the requirements specified in
FAR Subpart 32.9 for a proper invoice, the Contractor shall include the
following information on all payment requests:


 


(a)                                  Name of the Office of Acquisitions.  The Office of Acquisitions for this contract
is NIAID.


 


(b)                                 Central Point of Distribution.  For the purpose of this contract, the Central
Point of Distribution is NIAIDOAInvoices.


 


(c)                                  Vendor Identification Number.  This is the 7 digit number that appears after
the Contractor’s name in Block 7 of Standard Form 26.  (Note: 
This only applies to new contracts awarded on/after June 4, 2007,
and any existing contract modified to include the number.)


 


(d)                                 DUNS number or DUNS+4 that identifies the
Contractor’s name and address exactly as stated on the face page of the
contract.


 


(e)                                  Identification of whether payment is to be
made using a two-way or three-way match. 
This contract requires a two-way
match.


 


b.                                      Inquires regarding payment shall be directed
to the designated office, (301) 496-6088.


 


SECTION J — Attachment 2, Invoice/Financing Request Instructions
and Contract Financial Reporting for NIH Cost-Reimbursement Type Contracts
NIH(RC)-4 is hereby replaced with the following updated attachment.


 


HHS-556


 

















 


INVOICE/FINANCING
REQUEST AND CONTRACT FINANCIAL REPORTING INSTRUCTIONS FOR NIH
COST-REIMBURSEMENT CONTRACTS, NIH(RC)-4


 


Format:  Payment requests shall be submitted on the Contractor’s self-generated
form in the manner and format prescribed herein and as illustrated in the
Sample Invoice/Financing Request. 
Standard Form 1034, Public Voucher for Purchases and Services Other
Than Personal, may be used in lieu of the Contractor’s self-generated form
provided it contains all of the information shown on the Sample
Invoice/Financing Request.  DO NOT
include a cover letter with the payment request.


 


Number of Copies: 
Payment requests shall be submitted in the quantity specified in the
Invoice Submission Instructions in Section G of the Contract Schedule.


 


Frequency: 
Payment request shall not be submitted more frequently than once every
two weeks in accordance with the Allowable Cost and Payment Clause incorporated
into this contract.  Small business
concerns may submit invoices/financing requests more frequently than every two
weeks when authorized by the Contracting Officer.


 


Cost Incurrence Period:  Costs
incurred must be within the contract performance period or covered by
precontract cost provisions.


 


Billing of Costs Incurred:  If
billed costs include (1) costs of a prior billing period, but not
previously billed, or (2) costs incurred during the contract period and
claimed after the contract has expired, the Contractor shall site the amount(s) and
month(s) in which it incurred such costs.


 


Contractor’s Fiscal Year: 
Payment requests shall be prepared in such a manner that the Government
can identify costs claimed with the Contractor’s fiscal year.


 


Currency:  All
NIH contracts are expressed in United States dollars.  When the Government pays in a currency other
than United States dollars, billings shall be expressed, and payment by the
Government shall be made, in that other currency at amounts coincident with
actual costs incurred.  Currency
fluctuations may not be a basis of gain or loss to the Contractor.  Notwithstanding the above, the total of all
invoices paid under this contract may not exceed the United States dollars
authorized.


 


Costs Requiring Prior Approval:  Costs
requiring the Contracting Officer’s approval, which are not set forth in an
Advance Understanding in the contract, shall be identified and reference the
Contracting Officer’s Authorization (COA) Number.  In addition, the Contractor shall show any
cost set forth in an Advance Understanding as a separate line item on the
payment request.


 


Invoice/Financing Request
Identification:  Each payment request shall be identified as
either.


 


(a)         Interim Invoice/Contract Financing Request:  These
are interim payment requests submitted during the contract performance period.


 


(b)        Completion Invoice:  The completion invoice shall be submitted
promptly upon completion of the work, but no later than one year from the
contract completion date, or within 120 days after settlement of the final
indirect costs rates covering the year in which the contract is physically
complete (whichever date is later).  The
Contractor shall submit the completion invoice when all costs have been
assigned to the contract and it completes all performance provisions.


 


(c)         Final Invoice:  A final invoice may be required after the
amounts owed have been settled between the Government and Contractor (e.g.,
resolution of all suspensions and audit exceptions).


 


Preparation and Itemization of
the Invoice/Financing Request:  The Contractor shall furnish the
information set forth in the instructions below.  The instructions are keyed to the entries on
the Sample Invoice/Financing Request.


 


	
  NIH(RC)-4

  	
   

  	
  Attachment
  2

  
	
  Rev. 05/2007

  	
   

  	
  Page 1

  



 

















 


(a)         Designated Billing Office Name and Address:  Enter
the designated billing office name and address, as identified in the Invoice
Submission Instructions in Section G of the Contract Schedule.


 


(b)        Contractor’s Name, Address, Point of Contact, VIN, and DUNS or DUNS+4
Number:  Show the Contractor’s name and address
exactly as they appear in the contract, along with the name, title, phone
number, and e-mail address of the person to notify in the event of an improper
invoice or, in the case of payment by method other than Electronic Funds
Transfer, to whom payment is to be sent. 
Provide the Contractor’s vendor Identification Number (VIN), and Data
Universal Numbering System (DUNS) number or DUNS+4.  The DUNS number must identify the Contractor’s
name and address exactly as stated on the face page of the contract.  When an approved assignment has been made by
the Contractor, or a different payee has been designated, provide the same
information for the payee as is required for the Contractor (i.e., name,
address, point of contact, VIN, and DUNS).


 


(c)         Invoice/Financing Request Number:  Insert the appropriate serial
number of the payment request.


 


(d)        Date Invoice/Financing Request Prepared:  Insert
the date the payment request is prepared.


 


(e)         Contract Number and Order Number (if applicable):  Insert
the contract number and order number (if applicable)


 


(f)           Effective Date:  Insert the effective date of the contract or
if billing under an order, the effective date of the order.


 


(g)        Total Estimated Cost of Contract/Order:  Insert
the total estimated cost of the contract, exclusive of fixed-fee.  If billing under an order, insert the total
estimated cost of the order, exclusive of fixed-fee.  For incrementally funded contracts/orders,
enter the amount currently obligated and available for payment.


 


(h)        Total Fixed-Fee:  Insert the total fixed-fee (where
applicable).  For incrementally funded
contracts/orders, enter the amount currently obligated and available for
payment.


 


(i)            Two-way/Three-Way Match:  Identify whether payment is to
be made using a two-way or three-way match. 
To determine required payment method, refer to the Invoice Submission
Instructions in Section G of the Contract Schedule.


 


(j)            Office of Acquisitions:  Insert the name of the Office of
Acquisitions, as identified in the Invoice Submission Instructions in Section G
of the Contract Schedule.


 


(k)         Central Point of Distribution:  Insert the Central Point of
Distribution, as identified in the Invoice Submission Instructions in Section G
of the Contract Schedule.


 


(l)            Billing Period:  Insert the beginning and ending dates (month,
day, and year) of the period in which costs were incurred and for which
reimbursement is claimed.


 


(m)      Amount Billed — Current Period:  Insert the cumulative amounts
claimed for the current billing period by major cost element, including any
adjustments and fixed-fee.  If the
Contract Schedule contains separately priced line items, identify the contract
line item(s) on the payment request and include a separate breakdown (by
major cost element) for each line item.


 


(n)        Amount Billed — Cumulative:  Insert the cumulative amounts
claimed by major cost element, including any adjustments and fixed-fee.  If the Contract Schedule contains separately
priced line items, identify the contract line item(s) on the payment
request and include a separate breakdown (by major cost element) for each line
item.


 


(o)        Direct Costs:  Insert the major cost elements.  For each element, consider the application of
the paragraph entitled “Costs Requiring Prior Approval” on page 1 of these
instructions.


 


	
  NIH(RC)-4

  	
   

  	
  Attachment
  2

  
	
  Rev. 05/2007

  	
   

  	
  Page 2

  



 

















 


(1)        Direct Labor:  Include salaries and wages paid (or accrued)
for direct performance of the contract.


 


For Level of Effort contracts only, the
Contractor shall provide the following information on a separate sheet of paper
attached to the payment request.


 


· hours or percentage of effort and cost by labor category (as specified
in the Level of Effort Article in Section F of the contract) for the
current billing period, and


 


· hours or percentage of effort and cost by labor category from contract
inception through the current billing period. 
(NOTE:  The Contracting Officer
may require the Contractor to provide additional breakdown for direct labor,
such as position title, employee name, and salary or hourly rate.)


 


(2)        Fringe Benefits:  List any fringe benefits applicable to direct
labor and billed as a direct cost.  Do
not include in this category fringe benefits that are included in indirect
costs.


 


(3)        Accountable Personal Property:  Include permanent research
equipment and general purpose equipment having a unit acquisition cost of
$1,000 or more, with a life expectancy of more than two years, and sensitive
property regardless of cost (see the HHS Contractor’s Guide for
Control of Government Property). 
Show permanent research equipment separate from general purpose
equipment.


 


On a separate sheet of paper attached to the
payment request, list each item for which reimbursement is requested.  An asterisk (*) shall precede the item if the
equipment is below the $1,000 approval level. 
Include reference to the following (as applicable):


· item number for the specific piece of equipment listed in the Property
Schedule, and
 · COA number, if the equipment is not covered by the Property Schedule.


 


The Contracting Officer may require the
Contractor to provide further itemization of property having specific
limitations set forth in the contract.


 


(4)        Materials and Supplies:  Include equipment with unit costs of less
than $1,000 or an expected service life of two years or less, and consumable
material and supplies regardless of amount.


 


(5)        Premium Pay:  List remuneration in excess of the basic
hourly rate.


 


(6)        Consultant Fee:  List fees paid to consultants.  Identify consultant by name or category as
set forth in the contract or COA, as well as the effort (i.e. number of hours,
days, etc.) and rate billed.


 


(7)        Travel:  Include domestic and foreign travel.  Foreign travel is travel outside of Canada,
the United States and its territories and possessions.  However, for an organization located outside
Canada, the United States and its territories and possessions, foreign travel
means travel outside that country.  Foreign
travel must be billed separately from domestic travel.


 


(8)        Subcontract Costs:  List subcontractor(s) by name and amount
billed.


 


(9)        Other:  List all other direct costs in total unless
exceeding $1,000 in amount.  If over
$1,000, list cost elements and dollar amounts separately.  If the contract contains restrictions on any
cost element, that cost element must be listed separately.


 


(p)        Cost of Money (COM):  Cite the COM factor and base in effect during
the time the cost was incurred and for which reimbursement is claimed.


 


(q)        Indirect Costs:  Identify the indirect cost base (IDC),
indirect cost rate, and amount billed for each indirect cost category.


 


	
  NIH(RC)-4

  	
   

  	
  Attachment
  2

  
	
  Rev. 05/2007

  	
   

  	
  Page 3

  



 

















 


(r)           Fixed-Fee:  Cite the formula or method of computation for
fixed-fee, if applicable.  The fixed-fee
must be claimed as provided for by the contract.


 


(s)         Total Amounts Claimed:  Insert the total amounts claimed for the
current and cumulative periods.


 


(t)           Adjustments:  Include amounts conceded by the Contractor,
outstanding suspensions, and/or disapprovals subject to appeal.


 


(u)        Grand Totals


 


(v)        Certification of Salary Rate Limitation:  If
required by the contract (see Invoice Submission Instructions in Section G
of the Contract Schedule), the Contractor shall include the following
certification at the bottom of the payment request:


 


“I hereby certify that the salaries billed in
this payment request are in compliance with the Salary Rate Limitation
Provisions in Section H of the contract.”


 


The Contracting Officer may
require the Contractor to submit detailed support for costs claimed on one or
more interim payment requests.


 


FINANCIAL REPORTING INSTRUCTIONS:


 


These instructions are keyed to the Columns on
the sample invoice/financing request.


 


Column A — Expenditure Category:  Enter
the expenditure categories required by the contract.


 


Column B — Cumulative Percentage
of Effort/Hrs. — Negotiated:  Enter the percentage of effort
or number of hours agreed to for each employee or labor category listed in
Column A.


 


Column C — Cumulative Percentage
of Effort/Hrs. — Actual:  Enter the percentage of effort or number of
hours worked by each employee or labor category listed in Column A.


 


Column D — Amount Billed —
Current:  Enter amounts billed during the current
period.


 


Column E — Amount Billed —
Cumulative:  enter the cumulative amounts to date.


 


Column F — Cost at Completion:  Enter
data only when the Contractor estimates that a particular expenditure category
will vary from the amount negotiated. Realistic estimates are essential.


 


Column G — Contract Amount:  Enter
the costs agreed to for all expenditure categories listed in Column A.


 


Column H — Variance (Over or
Under):  Show the difference between the estimated
costs at completion (Column F) and negotiated costs (Column G) when entries
have been made in Column F.  This column
need not be filled in when Column F is blank. 
When a line item varies by plus or minus 10 percent, i.e., the
percentage arrived at by dividing Column F by Column G, an explanation of the
variance should be submitted.  In the
case of an overrun (net negative variance), this submission shall not be deemed
as notice under the Limitation of Cost (Funds) Clause of the contract.


 


Modifications:  Any
modification in the amount negotiated for an item since the preceding report
should be listed in the appropriate cost category.


 


Expenditures Not Negotiated:  An
expenditure for an item for which no amount was negotiated (e.g., at the
discretion of the Contractor in performance of its contract) should be listed
in the appropriate cost category and all columns filled in, except for G.  Column H will of course show a 100 percent
variance and will be explained along with those identified under H above.


 


	
  NIH(RC)-4

  	
   

  	
  Attachment
  2

  
	
  Rev. 05/2007

  	
   

  	
  Page 4

  



 

















 


SAMPLE
INVOICE/FINANCING REQUEST AND CONTRACT FINANCIAL REPORT


 


	
  (a)

  	
  Designated Billing Office Name and Address

  
	
   

  	
   

  
	
   

  	
  National Institutes of Health Office of Financial Management Commercial
  Accounts

  
	
   

  	
  2115 East Jefferson Street, Room 4B432, MSC 8500

  
	
   

  	
  Bethesda, MD  20892-8500

  
	
   

  	
   

  
	
  (b)

  	
  Contractor’s Name, Address, Point of Contact, VIN, and DUNS or DUNS+4
  Number:

  
	
   

  	
   

  
	
   

  	
  ABC Corporation

  
	
   

  	
  100 Main Street

  
	
   

  	
  Anywhere, USA Zip Code

  
	
   

  	
   

  
	
   

  	
  Name, Title, Phone Number, and E-mail Address of person to notify in
  the event of an improper invoice or, in the case of payment by method other
  than Electronic Funds Transfer, to whom payment is to be sent.

  
	
   

  	
   

  
	
   

  	
  VIN:

  
	
   

  	
  DUNS or DUNS+4:

  
	
   

  	
   

  
	
  (c)

  	
  Invoice/Financing Request No:

  
	
   

  	
   

  
	
  (d)

  	
  Date Invoice Prepared:

  
	
   

  	
   

  
	
  (e)

  	
  Contract No. and Order No. (If applicable):         

  
	
   

  	
   

  
	
  (f)

  	
  Effective Date:

  
	
   

  	
   

  
	
  (g)

  	
  Total Estimated Cost of Contract/Order:

  
	
   

  	
   

  
	
  (h)

  	
  Total Fixed-Fee (if applicable):

  
	
   

  	
   

  
	
  (i)

  	
  o Two-Way
  Match o Three-Way
  Match

  
	
   

  	
   

  
	
  (j)

  	
  Office of Acquisitions:

  
	
   

  	
   

  
	
  (k)

  	
  Central Point of Distribution:

  
	
   

  	
   

  
	
  (l)

  	
  This invoice/financing request represents reimbursable costs for the
  period from            
  to            

  



 


	
   

  	
   

  	
  Cumulative Percentage of

  Effort/Hrs.

  	
   

  	
  Amount Billed

  	
   

  	
  Cost of

  Completion

  F

  	
   

  	
  Contract Amount

  G

  	
   

  	
  Variance

  H

  	
   

  
	
  Expenditure Category*

  A

  	
   

  	
  Negotiated

  B

  	
   

  	
  Actual

  C

  	
   

  	
  (m)

  Current

  D

  	
   

  	
  (n)

  Cumulative

  E

  	
   

  
	
  (o) Direct Costs

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (1) Direct Labor

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (2) Fringe Benefits

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (3) Accountable Property

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (4) Materials & Supplies

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (5) Premium Pay

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (6) Consultant Fees

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (7) Travel

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (8) Subcontracts

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (9) Other

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Total Direct Costs

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (p) Cost of Money

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (q) Indirect Costs

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (r) Fixed Fee

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (s) Total Amount Claimed

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (t) Adjustments

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (u) Grand Totals

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  



 


I certify that all payments are for
appropriate purposes and in accordance with the contract.


 


	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  (Name of Official)

  	
   

  	
  (Title)

  	
   

  



 






*Attach details as specified in the contract.


 


	
  NIH(RC)-4

  	
   

  	
  Attachment
  2

  
	
  Rev. 05/2007

  	
   

  	
  Page 5

  



 
















 


	
  AMENDMENT OF
  SOLICITATION/MODIFICATION OF CONTRACT

  	
  1.   CONTRACT
  ID CODE

  	
  PAGE OF PAGES

  
	
   

  	
  N/A

  	
  1

  	
  20

  
	
   

  	
   

  	
   

  	
   

  
	
  2.   AMENDMENT/MODIFICATION
  NO

  	
  3.   EFFECTIVE
  DATE

  	
  4.   REQUISITION/PURCHASE
  REQ NO.

  	
  5.   PROJECT
  NO. (If applicable)

  
	
  07

  	
  See Block 16 C, below

  	
   

  	
  N/A

  
	
   

  	
   

  	
   

  	
   

  
	
  6.   ISSUED
  BY

  	
  CODE

  	
   

  	
  7.   ADMINISTERED
  BY (If other than Item 6)

  	
  CODE

  	
  N/A

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  National
  Institutes of Health, HHS

  National
  Institute of Allergy and Infectious Diseases

  DEA, Office of
  Acquisitions

  Room 3214,
  MSC 7612

  6700-B Rockledge
  Drive,

  Bethesda, MD  20892-7612

  	
   

  MID RCB-B

   

   

  VIN:  1109979

  
											



 


	
  8.   NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP Code)

  	
  x

  	
  9A.    AMENDMENT OF SOLICITATION
  NO.

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Avecia Limited

  	
   

  	
   

  	
   

  	
  9B.    DATED (SEE ITEM 11)

  
	
  P.O. Box 42, Hexagon House

  	
   

  	
   

  	
   

  	
   

  
	
  Blackley,
  Manchester, M9 8ZS, UK

  	
   

  	
   

  	
  x

  	
  10A.  MODIFICATION
  OF CONTRACT/ORDER NO.

  
	
   

  	
   

  	
   

  	
   

  	
  HHSN266200400034C

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
  10B.  DATED (SEE ITEM
  13)

  
	
  CODE

  	
   

  	
  FACILITY
  CODE

  	
   

  	
     September 30,
  2004

  



 


	
  11.  THIS ITEM ONLY APPLIES TO AMENDMENTS OF
  SOLICITATIONS

  
	
   

  
	
  o The above numbered solicitation is amended as set
  forth in Item 14.  The hour and date
  specified for receipt of Offers o is extended, o is not extended.  

   

  Offers must acknowledge
  receipt of this amendment prior to the hour and date specified in the
  solicitation or as amended, by one of the following methods:  

   

  (a) By completing
  Items 8 and 15, and returning one (1) copy of the amendment; (b) By
  acknowledging receipt of this amendment on each copy of the offer submitted;
  or (c) By separate letter or telegram which includes a reference to the
  solicitation and amendment numbers. 
  FAILURE OF YOUR ACKNOWLEDGEMENT TO BE RECEIVED AT THE PLACE DESIGNATED
  FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED
  MAY RESULT IN REJECTION OF YOUR OFFER. 
  If by virtue of this amendment, you desire to change an offer already
  submitted, such change may be made by telegram or letter, provided each
  telegram or letter makes reference to the solicitation and this amendment,
  and is received prior to the opening hour and date specified.

  
	
   

  
	
  12.     ACCOUNTING AND APPROPRIATION DATA (If required)

  
	
  EIN#:  1-900216013-A1

  	
  SOCC  25.55

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  13.     THIS ITEM APPLIES ONLY TO MODIFICATIONS OF
  CONTRACT/ORDERS,

  IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

  
	
   

  	
   

  
	
  x

  	
  A.       THIS CHANGE ORDER IS ISSUED PURSUANT
  TO:  (Specify
  authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE
  CONTRACT ORDER NO. IN ITEM 10A.

  
	
   

  	
   

  
	
   

  	
  B.       THE ABOVE NUMBERED CONTRACT/ORDER IS
  MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as
  changes in paying office, appropriate date, etc.) SET FORTH IN
  ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).

  
	
   

  	
   

  
	
  x

  	
  C.       THIS SUPPLEMENTAL AGREEMENT IS ENTERED
  INTO PURSUANT TO AUTHORITY OF:

  
	
  FAR 1.602-1

  
	
   

  	
   

  
	
   

  	
  D.       OTHER (Specify
  type of modification and authority)

  
	
   

  
	
   

  
	
  E.       IMPORTANT:  Contractor o is not, x is required to sign this document and
  return 2 copies to the issuing office.

  
	
   

  
	
  14.     DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract
  subject matter where feasible)

  
	
   

  
	
  PURPOSE:  To clarify the Part B Option
  Statement of Work, required Deliverables; and revise the related Milestone
  Estimated Cost and Fixed Fee distributions, as well as change the contract
  funded through and completion dates:

  
	
   

  
	
  TOTAL ESTIMATED
  COST:[***]

  	
  CONTRACT COMPLETION
  DATE: [***]

  
	
  TOTAL ALLOTTED TO DATE:
  [***]

  	
  FUNDED THROUGH
  DATE:  [***]

  
	
   

  	
   

  
	
  Except as provided
  herein, all terms and conditions of the document referenced in Item 9A or
  10A, as heretofore changed, remains unchanged and in full force and effect.

  
	
   

  	
   

  
	
  15A.  NAME AND TITLE OF SIGNER (Type or
  print)

  	
  16A.  NAME AND TITLE OF CONTRACTING OFFICER (Type or print)

  
	
  [***]

  	
  [***]

  [***]

  
	
   

  	
   

  	
   

  	
   

  
	
  15B.  CONTRACTOR/OFFEROR

  	
  15C.  DATE
  SIGNED

  	
  16B.  UNITED
  STATES OF AMERICA

  	
  16C.  DATE
  SIGNED

  
	
  [***]

  	
        9July’07

   

  	
  BY

  	
  [***]

  	
  [***]

  
	
  (Signature
  of person authorized to sign)

  	
  (Signature
  of Contracting Officer)

  
	
   

  	
   

  	
   

  
	
  NSN 7540-01-152-8070

  PREVIOUS EDITION
  UNUSABLE

  	
  30-105

  Computer Generated

  	
  STANDARD FORM 30
  (REV. 10-83)

  Prescribed by GSA

  FAR (48 CFR) 53.243

  
											



 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 07

  	
  SPECIAL PROVISIONS

  	
  Page 2 of 20

  



 


ARTICLE B.2.  ESTIMATED COST AND FIXED FEE, paragraph f., is hereby modified to read as
follows:


 


f.      It
is estimated that the amount currently allotted will cover performance of the
contract through [***].


 


ARTICLE B.4.  ADVANCED UNDERSTANDINGS, paragraph i., is hereby modified as follows
to update the Milestone Schedule:


 


	
   

  	
   

  	
  MILESTONES FOR AVECIA

  	
   

  	
  ESTIMATED

  COST

  	
   

  	
  FIXED FEE

  	
   

  	
  TOTAL

  CPFF

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  1

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in six
  installments of the total fee for this milestone based on the completion of
  the following six items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  	
   

  	
  b)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  	
   

  	
  c)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  d)
  [***]

  	
   

  	
   

  	
   

  	
  d)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  e)
  [***]

  	
   

  	
   

  	
   

  	
  e)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  f)
  [***]

  	
   

  	
   

  	
   

  	
  f)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Total
  Fee for Milestone

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  



 


	
  HHS-556

  



 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 07

  	
  SPECIAL PROVISIONS

  	
  Page 3 of 20

  



 


	
   

  	
   

  	
  MILESTONES FOR AVECIA

  	
   

  	
  ESTIMATED

  COST

  	
   

  	
  FIXED FEE

  	
   

  	
  TOTAL

  CPFF

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  2

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in five
  installments of the total fee for this milestone based on the completion of
  the following five items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  f) [***]

  	
   

  	
   

  	
   

  	
  f) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Total
  Fee for Milestone

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  



 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 07

  	
  SPECIAL PROVISIONS

  	
  Page 4 of 20

  



 


	
   

  	
   

  	
  MILESTONES FOR AVECIA

  	
   

  	
  ESTIMATED

  COST

  	
   

  	
  FIXED FEE

  	
   

  	
  TOTAL

  CPFF

  
	
  3

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in three
  installments of the total fee for this milestone based on the completion of
  the following three items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  [***]

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Total
  Fee for Milestone

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  4

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in three installments of the
  total fee for this milestone based on the completion of the following two
  items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Total
  Fee of Milestone

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  



 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 07

  	
  SPECIAL PROVISIONS

  	
  Page 5 of 20

  



 


	
   

  	
   

  	
  MILESTONES FOR AVECIA

  	
   

  	
  ESTIMATED

  COST

  	
   

  	
  FIXED FEE

  	
   

  	
  TOTAL

  CPFF

  
	
  5

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in three
  installments of the total fee for this milestone based on the completion of
  the following three items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Total
  Fee for Milestone

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  6

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in four
  installments of the total fee for this milestone based on the completion of
  the following four items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Total
  Fee of Milestone

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  



 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 07

  	
  SPECIAL PROVISIONS

  	
  Page 6 of 20

  



 


	
   

  	
   

  	
  MILESTONES FOR AVECIA

  	
   

  	
  ESTIMATED

  COST

  	
   

  	
  FIXED FEE

  	
   

  	
  TOTAL

  CPFF

  
	
  7

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in two
  installments of the total fee for this milestone based on the completion of
  the following two items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  	
   

  	
  a)
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Total
  Fee for Milestone

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  8

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in three
  installments of the total fee for this milestone based on the completion of
  the following three items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Total
  Fee of Milestone

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  



 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 07

  	
  SPECIAL PROVISIONS

  	
  Page 7 of 20

  



 


	
   

  	
   

  	
  MILESTONES FOR AVECIA

  	
   

  	
  ESTIMATED

  COST

  	
   

  	
  FIXED FEE

  	
   

  	
  TOTAL

  CPFF

  
	
  9

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in six
  installments of the total fee for this milestone based on the completion of
  the following six items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  f) [***]

  	
   

  	
   

  	
   

  	
  f) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Total
  Fee for Milestone

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  



 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 07

  	
  SPECIAL PROVISIONS

  	
  Page 8 of 20

  



 


	
   

  	
   

  	
  MILESTONES FOR AVECIA

  	
   

  	
  ESTIMATED

  COST

  	
   

  	
  FIXED FEE

  	
   

  	
  TOTAL

  CPFF

  
	
  10

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in four
  installments of the total fee for this milestone based on the completion of
  the following four items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Total
  Fee for Milestone

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  



 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 07

  	
  SPECIAL PROVISIONS

  	
  Page 9 of 20

  



 


	
   

  	
   

  	
  MILESTONES FOR AVECIA

  	
   

  	
  ESTIMATED

  COST

  	
   

  	
  FIXED FEE

  	
   

  	
  TOTAL

  CPFF

  
	
  11

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in four
  installments of the total fee for this milestone based on the completion of
  the following four items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  [***]

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Total
  Fee for Milestone

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  



 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 07

  	
  SPECIAL PROVISIONS

  	
  Page 10 of 20

  



 


	
   

  	
   

  	
  MILESTONES FOR AVECIA

  	
   

  	
  ESTIMATED

  COST

  	
   

  	
  FIXED FEE

  	
   

  	
  TOTAL

  CPFF

  
	
  12

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in nine
  installments of the total fee for this milestone based on the completion of
  the following nine items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  f) [***]

  	
   

  	
   

  	
   

  	
  f) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  g) [***]

  	
   

  	
   

  	
   

  	
  g) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  h) [***]

  	
   

  	
   

  	
   

  	
  h) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Total
  Fee for Milestone

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  



 


HHS-556


 
















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 07

  	
   

  	
  SPECIAL PROVISIONS

  	
   

  	
  Page 11 of 20

  



 


	
   

  	
   

  	
  MILESTONES FOR AVECIA

  	
   

  	
  ESTIMATED

  COST

  	
   

  	
  FIXED FEE

  	
   

  	
  TOTAL

  CPFF

  
	
  13

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be
  paid in eight installments of the total fee for this milestone based on the
  completion of the following eight items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  f) [***]

  	
   

  	
   

  	
   

  	
  f) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  g) [***]

  	
   

  	
   

  	
   

  	
  g) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  h) [***]

  	
   

  	
   

  	
   

  	
  h) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Total Fee
  for Milestone

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  



 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 07

  	
   

  	
  SPECIAL PROVISIONS

  	
   

  	
  Page 12 of 20

  



 


	
   

  	
   

  	
  MILESTONES FOR AVECIA

  	
   

  	
  ESTIMATED

  COST

  	
   

  	
  FIXED FEE

  	
   

  	
  TOTAL

  CPFF

  
	
  14

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in five installments of the total
  fee for this milestone based on the completion of the following five items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Total Fee for Milestone

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  



 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 07

  	
   

  	
  SPECIAL PROVISIONS

  	
   

  	
  Page 13 of 20

  



 


	
   

  	
   

  	
  MILESTONES FOR AVECIA

  	
   

  	
  ESTIMATED

  COST

  	
   

  	
  FIXED FEE

  	
   

  	
  TOTAL

  CPFF

  
	
  15

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in five installments of the total
  fee for this milestone based on the completion of the following five items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Total Fee for Milestone

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  



 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 07

  	
   

  	
  SPECIAL PROVISIONS

  	
   

  	
  Page 14 of 20

  



 


	
   

  	
   

  	
  MILESTONES FOR AVECIA

  	
   

  	
  ESTIMATED

  COST

  	
   

  	
  FIXED FEE

  	
   

  	
  TOTAL

  CPFF

  
	
  16

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in four installments of the total
  fee for this milestone based on the completion of the following four items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  	
   

  	
  d) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  	
   

  	
  e) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Total Fee for Milestone

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  



 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 07

  	
   

  	
  SPECIAL PROVISIONS

  	
   

  	
  Page 15 of 20

  



 


	
   

  	
   

  	
  MILESTONES FOR AVECIA

  	
   

  	
  ESTIMATED

  COST

  	
   

  	
  FIXED FEE

  	
   

  	
  TOTAL

  CPFF

  
	
  17

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Fee shall be paid in three installments of the
  total fee for this milestone based on the completion of the following three
  items:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  	
   

  	
  a) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  	
   

  	
  b) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  	
   

  	
  c) [***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Total Fee for Milestone

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  	
   

  



 


ARTICLE C.1.  STATEMENT OF WORK,
is hereby modified to read as follows:


 


Independently and not as an agent of the Government, the Contractor
shall furnish all the necessary services, qualified personnel, material,
equipment, and facilities, not otherwise provided by Government as needed to
perform the Statement of Work, SECTION J, ATTACHMENT 1, dated September 30,
2004, and as clarified by Modification No. 7 of the contract, attached hereto
and made part of this contract.


 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 07

  	
   

  	
  SPECIAL PROVISIONS

  	
   

  	
  Page 16 of 20

  



 


ARTICLE F.1.  PERIOD OF PERFORMANCE, paragraph a, is hereby modified to read as
follows:


 


a.             The period of
performance of this contract shall be from [***] through [***].


 


ARTICLE F.2.  DELIVERIES, paragraph a., is hereby modified to include the following
table of deliverables in addition to those deliveries currently required by the
contract.


 


	
  Item

  	
   

  	
  Type of Deliverable

  	
   

  	
  SOW Reference

  	
   

  	
  Recipient

  	
   

  	
  Delivery Schedule

  
	
  1.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
  2.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
  3.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
  4.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
  5.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
  6.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
  7.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
  8.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
  9.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
  10.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
  11.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
  12.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
  13.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  



 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 07

  	
   

  	
  SPECIAL PROVISIONS

  	
   

  	
  Page 17 of 20

  



 


	
  Item

  	
   

  	
  Type of Deliverable

  	
   

  	
  SOW Reference

  	
   

  	
  Recipient

  	
   

  	
  Delivery Schedule

  
	
  14.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
  15.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
  16.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
  17.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
  18.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
  19.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  
	
  20.

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  [***]

  



 


SECTION J — LIST OF ATTACHMENTS, items no. 1., is
hereby modified to read as follows:


 


1. [***] (and as clarified by Modification No. 7), 5 pages.


 


ATTACHMENT 1 — STATEMENT OF WORK,  is hereby modified to include the following
under the Part B Option section for clarification purposes:


 


[***]


 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 07

  	
   

  	
  SPECIAL PROVISIONS

  	
   

  	
  Page 18 of 20

  



 


[***]


 


[***]


 


[***]


 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 07

  	
   

  	
  SPECIAL PROVISIONS

  	
   

  	
  Page 19 of 20

  



 


[***]


 


[***]


 


[***]


 


[***]


 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 07

  	
   

  	
  SPECIAL PROVISIONS

  	
   

  	
  Page 20 of 20

  



 


[***]


 


[***]


 


HHS-556


 
















 


	
  AMENDMENT OF
  SOLICITATION/MODIFICATION OF CONTRACT

  	
  1.     CONTRACT
  ID CODE

  	
  PAGE       OF     PAGES

  
	
   

  	
  N/A

  	
  1

  	
  4

  
	
   

  	
   

  	
   

  	
   

  
	
  2.     AMENDMENT/MODIFICATION
  NO

  	
  3.

  	
  EFFECTIVE DATE

  	
  4.     REQUISITION/PURCHASE
  REQ. NO

  	
  5.     PROJECT
  NO. (if applicable)

  
	
  09

  	
   

  	
  See block 16C, below

  	
   

  	
  N/A

  
	
   

  	
   

  	
   

  	
   

  
	
  6.     ISSUED
  BY

  	
  CODE

  	
   

  	
  7.     ADMINISTERED
  BY (if other than Item 6)

  	
  CODE

  	
  N/A

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  National Institutes of
  Health

  National Institute of Allergy and Infectious Diseases

  DEA, Office of Acquisitions

  Room 3214, MSC 7612

  6700-B Rockledge Drive

  Bethesda, MD  20892-7612

  	
   

  	
     MID RCB-B

   

     N01-AI-40034

  
														



 


	
  8.     NAME AND ADDRESS OF CONTRACTOR (No., Street, County, State and ZIP Code)

  	
  x

  	
  9A.

  	
  AMENDMENT OF
  SOLICITATION NO.

  
	
   

  	
   

  	
   

  
	
  Avecia Biologics
  Limited VIN:  1140323

  	
   

  	
  9B.

  	
  DATED (SEE ITEM 11)

  
	
  P.O. Box 42,
  Hexagon Tower

  	
   

  	
   

  
	
  Blackley,
  Manchester, M9 8ZS, UK

  	
   

  	
   

  
	
   

  	
  x

  	
  10A.

  	
  MODIFICATION OF
  CONTRACT/ORDER NO.

  
	
   

  	
   

  	
   

  	
  HHSN266200400034C

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  10B.

  	
  DATED (SEE ITEM 13)

  
	
  CODE

  	
  FACILITY CODE

  	
   

  	
   

  	
  September 30, 2004

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  11.  THIS ITEM ONLY APPLIES TO AMENDMENTS OF
  SOLICITATIONS

  
						



 


	
  o The above numbered solicitation is amended as set
  forth in Item 14.  The hour and date
  specified for receipt of Offers o is extended, o is not extended. 

  

  Offers must acknowledge receipt of this amendment prior to the hour and date
  specified in the solicitation or as amended, by one of the following methods:
  

  

  (a) By completing Items 8 and 15, and returning one (1) copy of the
  amendment, (b) By acknowledging receipt of this amendment on each copy
  of the offer submitted or (c) By separate letter or telegram which
  includes a reference to the solicitation and amendment numbers.  FAILURE OF YOUR ACKNOWLEDGEMENT TO BE
  RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR
  AND DATA SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER.  If by virtue of this amendment you desire
  to change an offer already submitted, such change may be made by telegram or
  letter, provided each telegram or letter makes reference to the solicitation
  and this amendment, and is received prior to the opening hour and data
  specified.

  
	
   

  
	
  12.   ACCOUNTING AND APPROPRIATION DATA (if required)

  
	
   

  	
  N/A

  
	
   

  
	
  13. THIS ITEM APPLIES ONLY TO
  MODIFICATIONS OF CONTRACT/ORDERS,

  IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

  
	
   

  	
   

  
	
  (D)

  	
   A.  THIS
  CHANGE ORDER IS ISSUED PURSUANT TO (Specify authority)
  THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER NO. IN ITEM
  10A

  
	
   

  	
   

  
	
   

  	
   B.  THE
  ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE
  CHANGES (such as changes in paying office, appropriation
  date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR
  43.103(b)

  
	
   

  	
   

  
	
   

  	
   C.  THIS
  SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF

  
	
   

  
	
  x

  	
   D.  OTHER
  (Specify type of modification and authority)

  FAR 1.602-1 and Article G.1. Project
  Officer

  
	
   

  
	
  E.     IMPORTANT:  Contractor x is not, o is required to sign this document and
  return       copies to the issuing office

  
	
   

  
	
  14.        DESCRIPTION OF
  AMENDMENT/MODIFICATION (Organized by UCF section
  headings, including solicitation/contract subject matter where feasible)

  
	
   

  
	
  PURPOSE: 
  To revise ARTICLE G.1. and update Section H
  and I Articles.

  
			



 


	
   

  	
   

  	
  Total Funds Currently Allotted

  	
   

  	
   

  	
   

  	
  Total Estimated Cost

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Cost

  	
   

  	
  Fee

  	
   

  	
  Total

  	
   

  	
  Cost

  	
   

  	
  Fee

  	
   

  	
  Total

  	
   

  
	
  Prior to this Mod

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  $

  	
  50,701,800

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  $

  	
  50,701,800

  	
   

  
	
  This Mod #

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  $

  	
  0

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  $

  	
  0

  	
   

  
	
  Revised Total

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  $

  	
  50,701,800

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  $

  	
  50,701,800

  	
   

  



 


	
  Except as provided
  herein, all terms and conditions of the document referenced in Item 9A or
  10A, as heretofore changed, remains unchanged and in full force and effect.

  
	
   

  	
   

  
	
  15A.        NAME AND TITLE OF SIGNER (Type or print)

  	
  16A.

  	
  NAME AND TITLE OF
  CONTRACTING OFFICER (Type or print)

  
	
   

  	
   

  	
  Karen M. Gamble

  Contracting Officer, OA, DEA, NIAID

  
	
   

  	
   

  	
   

  	
   

  
	
  15B. CONTRACTOR/OFFEROR

  	
  15C. DATE SIGNED

  	
  16B.    UNITED
  STATES OF AMERICA

  	
  16C. DATE SIGNED

  
	
   

  	
   

  	
  BY

  	
  /s/ Karen M. Gamble

  	
  7/11/2008

  
	
   

  	
  (Signature
  of person authorized to sign)

  	
   (Signature of Contracting
  Officer)

  
	
   

  	
   

  	
   

  	
   

  
	
  NSN 7540-01-152-8070

  PREVIOUS EDITION UNUSABLE

  	
  30-105

  Computer Generated

  	
   

  	
  STANDARD FORM 30 (REV.
  10-83)

  Prescribed by GSA

  FAR (48 CFR) 53 243

  
									



 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 09

  	
   

  SPECIAL PROVISIONS

  	
   

  Page 2 of 4

  



 


ARTICLE G.1. 
PROJECT OFFICER,
Marlene Hammer is deleted as Alternate Project Officer.


 


The second paragraph is hereby modified to replace the Project Officer
as follows:




Freyja Lynn

Office of Biodefense Research Affairs

Division of Microbiology and Infectious Diseases

DHHS/NIH/NIAID

Room 5064, MSC 6604

6610 Rockledge Drive

Bethesda, MD 20892-6604

lynnf@niaid.nih.gov


 


THE FOLLOWING SECTION H ARTICLES ARE UPDATED IN COMPLIANCE WITH
PUBLIC LAW (P.L.) 110-161:


 


ARTICLE H.5. 
CONTINUED BAN ON FUNDING OF HUMAN EMBRYO RESEARCH is deleted in its entirety and replaced
with:


 


Pursuant to the current HHS annual appropriations act, the Contractor
shall not use contract funds for (1) the creation of a human embryo or
embryos for research purposes; or (2) research in which a human embryo or
embryos are destroyed, discarded, or knowingly subjected to risk of injury or
death greater than that allowed for research on fetuses in utero under 45 CFR
46.204(b) and Section 498(b) of the Public Health Service Act
(42 U.S.C. 289g(b)). 
The term “human embryo or embryos” includes any organism, not protected
as a human subject under 45 CFR 46 as of the date of the enactment of this Act,
that is derived by fertilization, parthenogenesis, cloning, or any other means
from one or more human gametes or human diploid cells.


 


Additionally, in accordance with a March 4, 1997 Presidential
Memorandum, Federal funds may not be used for cloning of human beings.


 


ARTICLE H.6. 
NEEDLE EXCHANGE
is deleted in its entirety and replaced with:


 


Pursuant to the current HHS annual appropriations act, the Contractor
shall not use contract funds to carry out any program of distributing sterile
needles or syringes for the hypodermic injection of any illegal drug.


 


ARTICLE H.11. 
SALARY RATE LIMITATION LEGISLATION PROVISIONS is deleted in its entirety and replaced
with:


 


a.               Pursuant
to the current HHS annual appropriations act, the Contractor shall not use NIH
Fiscal Year funds to pay the direct salary of an individual through this
contract at a rate in excess of Executive Level I.  Direct salary is exclusive of fringe
benefits, overhead and general and administrative expenses (also referred to as
“indirect costs” or “facilities and administrative (F&A) costs”).  Direct salary has the same meaning as the
term “institutional base salary.”  An
individual’s direct salary (or institutional base salary) is the annual
compensation that the Contractor pays for an individual’s appointment whether
that individual’s time is spent


 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 09

  	
  SPECIAL PROVISIONS

  	
  Page 3 of 4

  



 


on research, teaching, patient care or other
activities.  Direct salary (or
institutional base salary) excludes any income that an individual may be
permitted to earn outside of duties to the Contractor.  The annual salary rate limitation also
applies to individuals proposed under subcontracts.  It does not apply to fees paid to
consultants.  If this is a multiple year
contract, it may be subject to unilateral modifications by the Government if an
individual’s salary rate used to establish contract funding exceeds any salary
rate limitation subsequently established in future HHS appropriation acts.


 


b.              Payment
of direct salaries is limited to the Executive Level I rate which was in effect
on the date(s) the expense was incurred. 
See the following Web site for Executive Schedule rates of pay:




http://www.opm.gov/oca/.  (For current
year rates, click on Salaries and Wages /Executive Schedule /Rates of Pay for
the Executive Schedule.  For prior year rates, click on Salaries and
Wages / cursor to bottom of page and select year /Executive Schedule /
Rates of Pay for the Executive Schedule. 
Rates are effective January 1 of each calendar year unless
otherwise noted.)


 


	
  NOTE:

  	
  All
  prior Public Laws and related Executive Levels incorporated in the Basic
  Award and all previous Modifications shall remain in effect for the applicable
  fiscal year and related funds.

  



 


ARTICLE H.13. 
PRESS RELEASES 
is
deleted in its entirety and replaced with:


 


Pursuant to the current HHS annual appropriations act, the Contractor
shall clearly state, when issuing statements, press releases, requests for
proposals, bid solicitations and other documents describing projects or
programs funded in whole or in part with Federal money:  (1) the percentage of the total costs of
the program or project which will be financed with Federal money; (2) the
dollar amount of Federal funds for the project or program; and (3) the
percentage and dollar amount of the total costs of the project or program that
will be financed by nongovernmental sources.


 


THE FOLLOWING ARTICLE IS DELETED IN COMPLIANCE WITH PUBLIC LAW (P.L.) 110-161:


 


ARTICLE H.15. 
ANTI-LOBBYING
is deleted in its entirety.  It is now
covered under HHSAR Clause 352.270¬10, incorporated in ARTICLE 1.1.


 


ARTICLE H.16. 
OBTAINING AND DISSEMINATING BIOMEDICAL RESEARCH RESOURCES, is renumbered to read ARTICLE H.15.


 


ARTICLE H.17. 
SHARING RESEARCH DATA, is renumbered to read ARTICLE
H.16.


 


ARTICLE H.18. 
POSSESSION USE AN TRANSFR OF SECLECT BIOLOGICAL AGENTS OR TOXINS, is renumbered to read ARTICLE H.17.


 


ARTICLE H.19. 
PROHIBITION ON CONTRACTOR INVOLVEMENT WITH TERRORIST  ACTIVITIES, is renumbered to read ARTICLE H.18.


 


HHS-556


 

















 


	
  Contract
  No. HHSN266200400034C

  Modification No. 09

  	
  SPECIAL PROVISIONS

  	
  Page 4 of 4

  



 


THE
FOLLOWING NEW PROVISIONS ARE HEREBY ADDED TO THIS CONTRACT IN COMPLIANCE WITH
THE CONTINUING LEGISLATIVE MANDATES FOR FY2008 (P.L. 110-161).


 


ARTICLE H.19.  DISSEMINATION
OF FALSE OR DELIBERATELY MISLEADING SCIENTIFIC  INFORMATION


 


Pursuant to the current HHS annual appropriations act, the Contractor
shall not use contract funds to disseminate scientific information that is
deliberately false or misleading.


 


ARTICLE H.20.  RESTRICTION
ON EMPLOYMENT OF UNAUTHORIZED ALIEN WORKERS


 


Pursuant to the current HHS annual appropriations act, the Contractor
shall not use contract funds to employ workers described in section 274A(h)(3) of
the Immigration and Nationality Act, which reads as follows:


 


“(3) Definition of unauthorized alien.  As
used in this section, the term ‘unauthorized alien’ means, with respect to the
employment of an alien at a particular time, that the alien is not at that time
either (A) an alien lawfully admitted for permanent residence, or (B) authorized
to be so employed by this Act or by the Attorney General.”


 


ARTICLE H.21.  RESTRICTION
ON ABORTIONS


 


Pursuant to the current HHS annual appropriations act, the Contractor
shall not use contract funds for any abortion.


 


THE FOLLOWING SECTON H ARTICLE IS ADDED IN COMPLIANCE WITH PUBLIC LAW
(P.L.) 110-85:


 


ARTICLE H.22. 
REGISTRATION OF CLINICAL TRIALS IN THE GOVERNMENT DATABASE
(ClinicalTrials.gov)


 


Pursuant to Public Law 110-85, Food and Drug Administration Amendments
Act of 2007, Title VIII-Clinical Trial Databases, the Contractor shall register
the clinical trial(s) performed under this contract in the Government
database, ClinicalTrials.gov ( http://www.ClinicalTrials.gov)
by the later of December 27, 2007, or 21 days after the first patient is
enrolled.


 


Additional information is
available at:  http://prsinfo.clinicaltrials.gov.


 


THE FOLLOWING SECTON I ARTICLE IS UPDATED IN COMPLIANCE WITH PUBLIC LAW
(P.L.) 110-161:


 


ARTICLE I.1. 
GENERAL CONTRACT CLAUSES FOR A
COST-REIMBURSEMENT RESEARCH AND DEVELOPMENT CONTRACT, subparagraph b., is revised to add the
following clause:


 


HHSAR Clause No. 352.270-10,
Jan 2006, Anti-Lobbying


 


HHS-556


 
















 


	
  AMENDMENT
  OF SOLICITATION/MODIFICATION
  OF  CONTRACT

  	
  1.   CONTRACT
  ID CODE

  	
  PAGE    OF   
  PAGES

  
	
   

  	
  N/A

  	
  1

  	
   2

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  2.        AMENDMENT/MODIFICATION NO

  	
  3.  

  	
  EFFECTIVE DATE

  See block 16C, below

  	
  4.        REQUISITION/PURCHASE REQ. NO

  	
  5.

  	
  PROJECT NO. (if applicable)

  
	
   

  	
  10

  	
   

  	
  N/A

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  6.        ISSUED BY

  	
  CODE

  	
   

  	
  7.        ADMINISTERED BY (if other than
  item 6)

  	
  CODE

  	
  N/A

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  National Institutes of
  Health

  National Institute of Allergy and Infectious Diseases

  DEA, Office of Acquisitions

  Room 3214, MSC 7612

  6700-B Rockledge Drive

  Bethesda, MD  20892-7612

  	
   

  	
  MID RCB-B

  	
   

  
															



 


	
  8.        NAME AND ADDRESS OF CONTRACTOR (No., Street, County, State and ZIP Code)

  	
  x

  	
  9A.

  	
  AMENDMENT OF SOLICITATION NO.

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  PharmAthene UK Limited VIN:  1148445

  	
   

  	
   

  	
   

  	
  9B.

  	
  DATED (SEE ITEM 11)

  
	
  Johnson Matthey Building

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  PO Box 88,
  Haverton Hill Road

  	
   

  	
   

  	
  x

  	
  10A.

  	
  MODIFICATION OF CONTRACT/ORDER NO.

  
	
  Billingham, T523 1KN

  	
   

  	
   

  	
   

  	
   

  	
  HHSN266200400034C

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
  10B.

  	
  DATED (SEE  ITEM 13)

  
	
  CODE

  	
  FACILITY
  CODE

  	
   

  	
   

  	
  september 30, 2004

  
							



 


	
  11.  THIS ITEM ONLY APPLIES TO AMENDMENTS OF
  SOLICITATIONS

  
	
   

  
	
  o The above numbered solicitation is amended as set
  forth in Item 14.  The hour and date
  specified for receipt of Offers o is extended, o is not extended.

   

  Offers must acknowledge
  receipt of this amendment prior to the hour and date specified in the
  solicitation or as amended, by one of the following methods:

   

  (a) By completing
  Items 8 and 15, and returning one (1) copy of the amendment:  (b) By acknowledging receipt of this
  amendment on each copy of the offer submitted; or (c) By separate letter
  or telegram which includes a reference to the solicitation and amendment
  numbers.  FAILURE OF YOUR
  ACKNOWLEDGEMENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF
  OFFERS PRIOR TO THE HOUR AND DATA SPECIFIED MAY RESULT IN REJECTION OF
  YOUR OFFER.  If by virtue of this
  amendment you desire to change an offer already submitted, such change may be
  made by telegram or letter, provided each telegram or letter makes reference
  to the solicitation and this amendment, and is received prior to the opening
  hour and data specified.

  
	
   

  
	
  12.

  	
  ACCOUNTING AND
  APPROPRIATION DATA (if required)

  
	
   

  	
  SOCC 25.55

  
	
   

  	
   

  
	
  13. THIS
  ITEM APPLIES ONLY TO MODIFICATIONS OF CONTRACT/ORDERS,

  IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

  
	
   

  
	
  (C)

  	
  A.

  	
  THIS CHANGE ORDER IS
  ISSUED PURSUANT TO (specify
  authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT
  ORDER NO. IN ITEM 10A.

  
	
   

  	
   

  	
   

  
	
   

  	
  B.

  	
  THE ABOVE NUMBERED
  CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office, appropriation date, etc.)
  SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).

  
	
   

  	
   

  	
   

  
	
  x

  	
  C.

  	
  THIS SUPPLEMENTAL
  AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF

  FAR 42.12 and FAR 1.602-1

  
	
   

  	
   

  	
   

  
	
   

  	
  D.

  	
  OTHER (Specify type of
  modification and authority)

  
	
   

  
	
  E.       IMPORTANT:  Contractor o is not, x is required to sign this document and return
     2   copies to the issuing office.

  
	
   

  
	
  14.     DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject
  matter where feasible)

  
	
   

  
	
  PURPOSE:  To recognize
  the Contractor’s successor in interest from Avecia Biologics Limited to
  PharmAthene UK, Limited; to revise ARTICLE B4 ADVANCE UNDERSTANDINGS and
  ARTICLE G4. PROJECT OFFICER

  
				



 


	
   

  	
   

  	
  total funds currently allotted

  	
   

  	
   

  	
   

  	
  total estimated cost

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  cost

  	
   

  	
  fee

  	
   

  	
  total

  	
   

  	
  cost

  	
   

  	
  fee

  	
   

  	
  total

  	
   

  
	
  Prior to this Mod

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  $

  	
  50,701,800

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  $

  	
  50,701,800

  	
   

  
	
  This Mod #

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  $

  	
  -0-

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  $

  	
  -0-

  	
   

  
	
  Revised Total

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  $

  	
  50,701,800

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  	
  $

  	
  50,701,800

  	
   

  



 


	
  FUNDED THROUGH DATE:  September 29, 2010 (Unchanged)

  	
   

  	
  CONTRACT COMPLETION
  DATE:  September 29, 2010
  (Unchanged)

  
	
   

  
	
  Except as provided herein, all terms and conditions
  of the document referenced in Item 9A or 10A, as heretofore changed, remains
  unchanged and in full force and effect.

  



 


	
  15A.             NAME AND TITLE OF SIGNER (Type or print)

  	
  16A.

  	
  NAME AND TITLE OF
  CONTRACTING OFFICER (Type or print)

  
	
  Chris Camut, VP, CFO/ UK
  Board of Directors

  	
   

  	
  Karen M. Gamble

  Contracting Officer, MID, RCB, B-OA, DEA, NIAID

  
	
   

  	
   

  	
   

  	
   

  
	
  15B. CONTRACTOR/OFFEROR

  	
  15C. DATE SIGNED

  	
  16B.

  	
  UNITED STATES OF AMERICA

  	
  16C. DATE SIGNED

  
	
  /s/ Chris Camut

  	
  12/4/08

  	
  BY

  	
  /s/ Karen M.
  Gamble

  	
  12/4/2008

  
	
  (Signature of person authorized to sign)

  	
   

  	
  (Signature of Contracting Officer)

  
	
   

  	
   

  	
   

  	
   

  
	
  NSN
  7540-01-152-8070

  PREVIOUS
  EDITION UNUSABLE

  	
  30-105

  Computer
  Generated

  	
   

  	
  STANDARD FORM 30
  (REV. 10-83)

  Prescribed by GSA

  FAR (48 CFR) 53.243

  
								



 

















 




	
  Contract
  no. HHSN266200400034C

  Modification No. 10

  	
   

  	
  SPECIAL
  PROVISIONS

  	
   

  	
  page 2
  of 2

  






 


Pursuant to far 42.12, Block
8 of the Standard Form 38 shall read as follows:


 


PharmAthene UK Limited  VIN:  1148448

Johnson Matthey Building

PO Box 88, Haverton Hill Road

Billingham TS23 1XN


 


The
following is attached and made part of this modification:


 


Novation Agreement

Exhibit A, List of all Affected Contracts


 


ARTICLE B.4.  ADVANCED UNDERSTANDINGS,
is modified to add the following:


 


9.               ceilings


 


As a result of this novation,
it is agreed that the Total Estimated Cost of this Contract shall not exceed
the current value of $50,701,800, due to any variances in the indirect costs.


 


ARTICLE
G.1.  PROJECT OFFICER,
is modified to add the following.


 


The Alternate Project Officer
named below will represent the Government for the purpose of this contract:


 


Nancy Wilkie

Office of Biodefense Research Affaris (OBRA)

Division of Microbiology and Infectious Diseases

DHHS/NIH/NIAID

Room 5004, MSC 6604

6610 Rockledge Drive

Bethesda, MD  20892-6604

wilkien@niaid.nih.gov


 


HHS-556


 

















 


NOVATION AGREEMENT


 


AVECIA BIOLOGICS LIMITED (Transferor), a
corporation duly organized and existing under the laws of England and Wales
with its principal office in Manchester United Kingdom; PHARMATHENE
UK LIMITED (Transferee), a corporation duly organized and existing
under the laws of England and Wales with its principal office in Billingham,
UK; and the UNITED STATES OF AMERICA
(Government) enter into this Agreement as of 2nd April, 2008.


 


(a) The
parties agree to the following facts:


 


(1) The Government, represented by various Contracting Officers of
the National Institute for Allergies and Infectious Diseases, has entered into
certain contracts with the Transferor as shown in the attached list marked ‘Exhibit A’
and incorporated in this Agreement by reference.  The term “the contracts,” as used in this
Agreement, means the above contracts and purchase orders and all other
contracts and purchase orders, including all modifications, made between the
Government and the Transferor before the effective date of this Agreement
(whether or not performance and payment have been completed and releases
executed if the Government or the Transferor has any remaining rights, duties,
or obligations under these contracts and purchase orders).  Included in the term “the contracts” are also
all modifications made under the terms and conditions of these contracts and
purchase orders between the Government and the Transferee, on or after the
effective date of this Agreement.


 


(2) As of 2nd April, 2008, the Transferor has transferred to
the Transferee all the assets of the Transferor by virtue of a Sale and
Purchase Agreement between the Transferor and the Transferee.


 


(3) The Transferee has acquired all the assets of the Transferor
by virtue of the above transfer.


 


(4) The Transferee has assumed all obligations and liabilities of
the Transferor under the contracts by virtue of the above transfer.


 


(5) The Transferee is in a position to fully perform all
obligations that may exist under the contracts.


 


(6) It is consistent with the Government’s interest to recognize
the Transferee as the successor party to the contracts.


 


(7) Evidence of the above transfer has been filed with the
Government.


 


(b) In
consideration of these facts, the parties agree that by this Agreement—


 


(1) The Transferor confirms the transfer to the Transferee, and
waives any claims and rights against the Government that it now has or may have
in the future in connection with the contracts.


 


(2) The Transferee agrees to be bound by and to perform each
contract in accordance with the conditions contained in the contracts.  The Transferee also


 

















 


assumes all
obligations and liabilities of, and all claims against, the Transferor under
the contracts as if the Transferee were the original party to the contracts.


 


(3) The Transferee ratifies all previous actions taken by the
Transferor with respect to the contracts, with the same force and effect as if
the action had been taken by the Transferee.


 


(4) The Government recognizes the Transferee as the Transferor’s
successor in interest in and to the contracts. 
The Transferee by this Agreement becomes entitled to all rights, titles,
and interests of the Transferor in and to the contracts as if the Transferee
were the original party to the contracts. 
Following the effective date of this Agreement, the term “Contractor,”
as used in the contracts, shall refer to the Transferee.


 


(5) Except as expressly provided in this Agreement, nothing in it
shall be construed as a waiver of any rights of the Government against the
Transferor.


 


(6) All payments and reimbursements previously made by the
Government to the Transferor, and all other previous actions taken by the
Government under the contracts, shall be considered to have discharged those
parts of the Government’s obligations under the contracts.  All payments and reimbursements made by the
Government after the date of this Agreement in the name of or to the Transferor
shah have the same force and effect as if made to the Transferee, and shall
constitute a complete discharge of the Government’s obligations under the
contracts, to the extent of the amounts paid or reimbursed.


 


(7) The Transferor and the Transferee agree that the Government is
not obligated to pay or reimburse either of them for, or otherwise give effect
to, any costs, taxes, or other expenses, or any related increases, directly or
indirectly arising out of or resulting from the transfer or this Agreement,
other than those that the Government in the absence of this transfer or
Agreement would have been obligated to pay or reimburse under the terms of the
contracts.


 


(8) The Transferor guarantees payment of all liabilities and the
performance of all obligations that the Transferee—


 


(i) Assumes under this Agreement; or


 


(ii) May undertake in the future should these contracts be
modified under their terms and conditions. 
The Transferor waives notice of, and consents to, any such future
modifications.


 


(9) The contracts shall remain in full force and effect, except as
modified by this Agreement.  Each party
has executed this Agreement as of the day and year first above written.


 


UNITED STATES
OF AMERICA,


 


	
  Signed

  	
  [ * * * ]

  	
   

  
	
   

  	
   

  	
   

  
	
  Name and
  Title

  	
  [ * * * ]

  	
   

  



 

















 


AVECIA BIOLOGICS LIMITED,


 


	
  Signed

  	
  /s/ Duncan
  McLellan

  	
   

  
	
  Name and
  Title

  	
  Duncan McLellan,
  Director and Chief Financial Officer

  	
   

  



 


PHARMATHENE UK LIMITED,


 


	
  Signed

  	
  /s/ David P.
  Wright

  	
   

  
	
  Name and
  Title

  	
  David P.
  Wright - CEO

  	
   

  



 


CERTIFICATE


 


I, Richard
clements, certify that I am
the Company Secretary of AVECIA BIOLOGICS LIMITED, that Duncan McLellan, who
signed this Agreement for this corporation, was then a Director and the Chief
Financial Officer of this corporation; and that this Agreement was duly signed
for and on behalf of this corporation by authority of its governing body and
within the scope of its corporate powers. 
Witness my hand this day of 2nd June 2008.


 


	
  Signed

  	
  /s/ Richard
  Clements

  	
   

  



 


CERTIFICATE


 


I, Christopher c. camut, certify that I am
the Company Secretary of PHARMATHENE UK LIMITED, that David P. Wright, who
signed this Agreement for this corporation, was then a Director of this
corporation; and that this Agreement was duly signed for and on behalf of this
corporation by authority of its governing body and within the scope of its
corporate powers.  Witness my hand this
day of 23 June 2008.


 


	
  Signed

  	
  /s/
  Christopher C. Camut

  	
   

  



 

















 


Exhibit A


 


The Contracts


 


Contract
number N01-Al-25492


 


Contract between Avecia Biologics Limited and
the National Institute of Allergy and Infectious Diseases (NIAID), part of the
US National Institutes of Health (NIH), for “Development and Testing of
Vaccines Against Anthrax.”


 


Contract
number N01-Al-30052


 


Contract between Avecia Biologics Limited and
the National Institute of Allergy and Infectious Diseases (NIAID), part of the
US National Institutes of Health (NIH), for “Production and Testing of Anthrax
Recombinant Protective Antigen.”


 


Contract
number HHSN266200400034C, N01-Al-40034


 


Contract between Avecia Biologics Limited and
the National Institute of Allergy and Infectious Diseases (NIAID), part of the
US National Institutes of Health (NIH), for “Development, Testing and
Evaluation of Candidate Vaccines Against Plague.”


 

















 


List of Affected Contracts


 


Contract
number N01-Al-25492


 


Contract between Avecia Biologics Limited and
the National Institute of Allergy and Infectious Diseases (NAID), part of the
US National Institutes of Health (NIH), for “Development and Testing of
Vaccines Against Anthrax.”


 


This contract is substantially complete.  As at 15th January 2008,
the total contract amount was $10,155,120 and there was an [
* * * ] which is under discussion between Avecia Biologics Limited and
NAID.


 


	
  Contracting
  Office:

  	
  National Institutes
  of Health

  
	
   

  	
  Office of
  Acquisitions, NIAID

  
	
   

  	
  Room 3214

  
	
   

  	
  6700-8
  Rockledge Dr., MSC 7612

  
	
   

  	
  Bethesda,
  Maryland 20892-7612

  



 


Contract
number N01-Al-30052


 


Contract between Avecia Biologics Limited and
the National Institute of Allergy and Infectious Diseases (NIAID), part of the
US National Institutes of Health (NIH), for “Production and Testing of Anthrax
Recombinant Protective Antigen.’


 


As at 15th April 2008,
the total contract value was $118,036,200 and the total estimated costs
remaining to complete were 
[ * * * ].


 


	
  Contracting
  Office:

  	
  National
  Institutes of Health

  
	
   

  	
  Office of
  Acquisitions, NIAID

  
	
   

  	
  Room 3214

  
	
   

  	
  6700-B
  Rockledge Dr., MSC 7612

  
	
   

  	
  Bethesda,
  Maryland 20892-7612

  



 


Contract number HHSN266200400034C,
N01-AI-40034


 


Contract between Avecia Biologics Limited and
the National Institute of Allergy and Infectious Diseases (NIAID), part of the
US National Institutes of Health (NIH), for “Development, Testing and
Evaluation of Candidate Vaccines Against Plague.”


 


As at 15th April 2008,
the total contract value was $50,701,714 and the total estimated costs
remaining to complete were [ * * * ].


 


	
  Contracting
  Office:

  	
  National
  Institutes of Health

  
	
   

  	
  Office of
  Acquisitions, NIAID

  
	
   

  	
  Room 3214

  
	
   

  	
  6700-B
  Rockledge Dr., MSC 7612

  
	
   

  	
  Bethesda,
  Maryland 20892-7612